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Search of human proteins with 118600983
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens]
(1321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens] 2765 0.0
gi|21361116 versican isoform 1 [Homo sapiens] 386 e-107
gi|187607300 versican isoform 2 [Homo sapiens] 379 e-104
gi|38372931 brevican isoform 2 [Homo sapiens] 332 1e-90
gi|38372935 brevican isoform 1 [Homo sapiens] 332 1e-90
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 328 3e-89
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 328 3e-89
gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo sap... 234 5e-61
gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo sap... 222 2e-57
gi|11141887 brain link protein-1 [Homo sapiens] 216 1e-55
gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo sapi... 210 8e-54
gi|110624774 mannose receptor, C type 2 [Homo sapiens] 122 3e-27
gi|24041035 notch 2 preproprotein [Homo sapiens] 100 2e-20
gi|148833508 notch1 preproprotein [Homo sapiens] 97 1e-19
gi|112420992 crumbs homolog 2 [Homo sapiens] 96 2e-19
gi|134244285 Notch homolog 3 [Homo sapiens] 96 2e-19
gi|4505245 mannose receptor C type 1 precursor [Homo sapiens] 96 2e-19
gi|18641360 collectin sub-family member 12 [Homo sapiens] 95 4e-19
gi|4759146 slit homolog 2 [Homo sapiens] 94 9e-19
gi|20149533 Fc fragment of IgE, low affinity II, receptor for (C... 94 1e-18
gi|53832016 C-type lectin, superfamily member 14 isoform 2 [Homo... 93 2e-18
gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens] 92 3e-18
gi|11321571 slit homolog 3 [Homo sapiens] 92 3e-18
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 91 6e-18
gi|33667103 C-type lectin, superfamily member 14 isoform 1 [Homo... 91 6e-18
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 91 7e-18
gi|4557679 jagged 1 precursor [Homo sapiens] 90 2e-17
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 90 2e-17
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 90 2e-17
gi|110735443 delta-like 1 [Homo sapiens] 89 4e-17
>gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens]
Length = 1321
Score = 2765 bits (7167), Expect = 0.0
Identities = 1321/1321 (100%), Positives = 1321/1321 (100%)
Query: 1 MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCL 60
MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCL
Sbjct: 1 MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCL 60
Query: 61 FTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR 120
FTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR
Sbjct: 61 FTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR 120
Query: 121 ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE 180
ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE
Sbjct: 121 ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE 180
Query: 181 ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY 240
ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY
Sbjct: 181 ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY 240
Query: 241 GRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEG 300
GRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEG
Sbjct: 241 GRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEG 300
Query: 301 LDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHH 360
LDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHH
Sbjct: 301 LDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHH 360
Query: 361 PTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILE 420
PTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILE
Sbjct: 361 PTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILE 420
Query: 421 EKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRR 480
EKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRR
Sbjct: 421 EKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRR 480
Query: 481 GRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSP 540
GRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSP
Sbjct: 481 GRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSP 540
Query: 541 WADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATP 600
WADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATP
Sbjct: 541 WADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATP 600
Query: 601 DLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAH 660
DLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAH
Sbjct: 601 DLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAH 660
Query: 661 GEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAE 720
GEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAE
Sbjct: 661 GEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAE 720
Query: 721 HSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQD 780
HSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQD
Sbjct: 721 HSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQD 780
Query: 781 PWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDA 840
PWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDA
Sbjct: 781 PWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDA 840
Query: 841 SGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPE 900
SGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPE
Sbjct: 841 SGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPE 900
Query: 901 PEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLL 960
PEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLL
Sbjct: 901 PEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLL 960
Query: 961 PVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHG 1020
PVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHG
Sbjct: 961 PVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHG 1020
Query: 1021 GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSF 1080
GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSF
Sbjct: 1021 GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSF 1080
Query: 1081 CEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH 1140
CEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH
Sbjct: 1081 CEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH 1140
Query: 1141 ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPC 1200
ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPC
Sbjct: 1141 ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPC 1200
Query: 1201 NYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRS 1260
NYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRS
Sbjct: 1201 NYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRS 1260
Query: 1261 NGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF 1320
NGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF
Sbjct: 1261 NGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF 1320
Query: 1321 C 1321
C
Sbjct: 1321 C 1321
>gi|21361116 versican isoform 1 [Homo sapiens]
Length = 3396
Score = 386 bits (992), Expect = e-107
Identities = 199/520 (38%), Positives = 276/520 (53%), Gaps = 43/520 (8%)
Query: 789 GLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASG------ 842
G SP V + P+ E ++ E P+++P D+ + P+ D
Sbjct: 2855 GSSVMSPQDSFKEIHVNIEATFKPSSEEYLHITEPPSLSP-DTKLEPSEDDGKPELLEEM 2913
Query: 843 -------IWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSS 895
I G+++ ++ ++ T + + T E G + L ++
Sbjct: 2914 EASPTELIAVEGTEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVITTADEIELEGATQ 2973
Query: 896 QPHPEPEDQVETQGTSGASVP------PHQSSPLGKPAVPPGTPTAASVGESASVSSGEP 949
PH T G VP + + P + P T A G+ +++++ E
Sbjct: 2974 WPHSTSASA--TYGVEAGVVPWLSPQTSERPTLSSSPEINPETQAALIRGQDSTIAASEQ 3031
Query: 950 TVPW-----DPSSTLLPVTLGIEDFE-----LEVLAGSPGVESFWEEVASGEEPALPGTP 999
V + +T+ PV E LE + + EE G LPG
Sbjct: 3032 QVAARILDSNDQATVNPVEFNTEVATPPFSLLETSNETDFLIGINEESVEGTAIYLPGP- 3090
Query: 1000 MNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGG 1059
D C+ NPCL+GGTC T Y C+C G++G+ CE+D D+C +PC NG
Sbjct: 3091 ----------DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGA 3140
Query: 1060 TCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRR 1119
TC+D N F CLCLPSY G+ CE+DTE CD GWHKFQG CY+YFAHRR W+ AE++CR +
Sbjct: 3141 TCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQ 3200
Query: 1120 SGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFA 1179
HLTS+ S EE F+N GH+ WIGLND++ E DF+WTD + LQ+ENWR NQPD+FF+
Sbjct: 3201 GAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFS 3260
Query: 1180 GGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHAT 1239
GEDCVV++ HE+G+WNDVPCNY+L Y CKKGTV CG PP VENA G K +Y +++
Sbjct: 3261 AGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSL 3320
Query: 1240 VRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHR 1279
+RY C +GF Q H+ TIRC NG+W P+I C P R
Sbjct: 3321 IRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCMNPSAYQR 3360
Score = 338 bits (867), Expect = 2e-92
Identities = 183/429 (42%), Positives = 255/429 (59%), Gaps = 15/429 (3%)
Query: 37 LHMQKLG-SGSVQAALAELVALPCLFTLQPRPSAARDAP---RIKWTKVRTASGQR--QD 90
LH K+G S V+ +L+ V+LPC F+ P + + RIKW+K+ + ++
Sbjct: 21 LHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKE 80
Query: 91 LPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQ 150
+LVA++ +++ + ++GRVS+P++P +A+L + L ASD+GLYRC V+ GIED Q
Sbjct: 81 TTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQ 140
Query: 151 DLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGW 210
D V L V GVVFHYR+A RY L F AQ+AC A+IA P L AA+EDGF+ CDAGW
Sbjct: 141 DTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGW 200
Query: 211 LSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARR 270
L+D+TVRYPI R GCYGD+ GVR+YG R+PQE YDVYC+ L G+VF++ +
Sbjct: 201 LADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSK 260
Query: 271 LTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAP 330
T A +C Q A LA+VG+L AW G DQCD GWL+D SVR+P+ R +CGG
Sbjct: 261 FTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLL 320
Query: 331 GVRTVYRFANRTGFPSPAERFDAYCFRAHHPT----SQHGDLETPSSGDEGEILSAEGPP 386
GVRT+YRF N+TGFP P RFDAYCF+ T S + +PS E +++S P
Sbjct: 321 GVRTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILAETASPSLSKEPQMVSDRTTP 380
Query: 387 VRELEPTLEEEEVVTPDFQE--PLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTG 444
+ P ++E V+ +F +VS ++ T+ + +S T PTP W
Sbjct: 381 I---IPLVDELPVIPTEFPPVGNIVSFEQKATVQPQAITDSLATKLPTPTGSTKKPWDMD 437
Query: 445 EVWLSTVAP 453
+ S P
Sbjct: 438 DYSPSASGP 446
Score = 31.2 bits (69), Expect = 6.9
Identities = 46/184 (25%), Positives = 72/184 (39%), Gaps = 27/184 (14%)
Query: 375 DEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLI-------LEEKQESQQ 427
D+ EI+ G R E E+++ P FQ P SSG EE L+ + Q
Sbjct: 2733 DQSEIIPTLGQFERTQEE-YEDKKHAGPSFQ-PEFSSGAEEALVDHTPYLSIATTHLMDQ 2790
Query: 428 TLSPTPGDPMLASWP-----------TGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPM 476
+++ P D M S P T S SP + +G+ AS HTE+ +
Sbjct: 2791 SVTEVP-DVMEGSNPPYYTDTTLAVSTFAKLSSQTPSSPLTIYSGSEASGHTEIPQPSAL 2849
Query: 477 PRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQ 536
P + Q+ + +EA+ + P+SE ++ EPP T++ S
Sbjct: 2850 PG-----IDVGSSVMSPQDSFKEIHVNIEATFK-PSSEEYLHITEPPSLSPDTKLEPSED 2903
Query: 537 SRSP 540
P
Sbjct: 2904 DGKP 2907
>gi|187607300 versican isoform 2 [Homo sapiens]
Length = 655
Score = 379 bits (973), Expect = e-104
Identities = 155/270 (57%), Positives = 196/270 (72%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C+ NPCL+GGTC T Y C+C G++G+ CE+D D+C +PC NG TC+D N F
Sbjct: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSP 1129
CLCLPSY G+ CE+DTE CD GWHKFQG CY+YFAHRR W+ AE++CR + HLTS+ S
Sbjct: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSH 469
Query: 1130 EEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVA 1189
EE F+N GH+ WIGLND++ E DF+WTD + LQ+ENWR NQPD+FF+ GEDCVV++
Sbjct: 470 EEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIW 529
Query: 1190 HESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFA 1249
HE+G+WNDVPCNY+L Y CKKGTV CG PP VENA G K +Y +++ +RY C +GF
Sbjct: 530 HENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFI 589
Query: 1250 QHHVATIRCRSNGKWDRPQIVCTKPRRSHR 1279
Q H+ TIRC NG+W P+I C P R
Sbjct: 590 QRHLPTIRCLGNGRWAIPKITCMNPSAYQR 619
Score = 327 bits (837), Expect = 6e-89
Identities = 161/327 (49%), Positives = 216/327 (66%), Gaps = 6/327 (1%)
Query: 37 LHMQKLG-SGSVQAALAELVALPCLFTLQPRPSAARDAP---RIKWTKVRTASGQR--QD 90
LH K+G S V+ +L+ V+LPC F+ P + + RIKW+K+ + ++
Sbjct: 21 LHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKE 80
Query: 91 LPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQ 150
+LVA++ +++ + ++GRVS+P++P +A+L + L ASD+GLYRC V+ GIED Q
Sbjct: 81 TTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQ 140
Query: 151 DLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGW 210
D V L V GVVFHYR+A RY L F AQ+AC A+IA P L AA+EDGF+ CDAGW
Sbjct: 141 DTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGW 200
Query: 211 LSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARR 270
L+D+TVRYPI R GCYGD+ GVR+YG R+PQE YDVYC+ L G+VF++ +
Sbjct: 201 LADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSK 260
Query: 271 LTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAP 330
T A +C Q A LA+VG+L AW G DQCD GWL+D SVR+P+ R +CGG
Sbjct: 261 FTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLL 320
Query: 331 GVRTVYRFANRTGFPSPAERFDAYCFR 357
GVRT+YRF N+TGFP P RFDAYCF+
Sbjct: 321 GVRTLYRFENQTGFPPPDSRFDAYCFK 347
Score = 74.7 bits (182), Expect = 5e-13
Identities = 38/89 (42%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Query: 271 LTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAP 330
L A+ C GA +A+ QL A+ +G +QCD GWLAD +VRYPI+ PR C G
Sbjct: 163 LNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKM 222
Query: 331 GVRTVYRFANRTGFPSPAERFDAYCFRAH 359
G V + GF SP E +D YC+ H
Sbjct: 223 GKAGVRTY----GFRSPQETYDVYCYVDH 247
>gi|38372931 brevican isoform 2 [Homo sapiens]
Length = 671
Score = 332 bits (851), Expect = 1e-90
Identities = 182/447 (40%), Positives = 256/447 (57%), Gaps = 17/447 (3%)
Query: 9 LGLLMLQMLLFVAGEQGTQDITD---ASERGLHMQKLGSGSVQAALAELVALPC-LFTLQ 64
L L +L L+ D+ + + +R ++ G +Q L + +PC + L+
Sbjct: 4 LFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLR 63
Query: 65 PRPS--AARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRAN 122
P PS A +PR+KWT + + ++ +LVA+ V+V ++++ RV+LP+YP +
Sbjct: 64 PPPSRRAVLGSPRVKWTFL----SRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTD 119
Query: 123 ATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEAC 182
+L L LR +DSG+YRC+V GI+D D V ++V GVVF YR RYA +F+ AQEAC
Sbjct: 120 VSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEAC 179
Query: 183 RLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGR 242
A IA P L AA+ G++ CDAGWLSD+TVRYPI R CYGD PGVR+YG
Sbjct: 180 ARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGV 239
Query: 243 RNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLD 302
+P +LYDVYC+A +L GE+F P +LTL ARA C+ +GA +A+ GQL+ AW GLD
Sbjct: 240 VDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLD 299
Query: 303 QCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPT 362
C PGWLADGSVRYPI TP +RCGG PGV+T++ F N+TGFP+ RF+ YCFR
Sbjct: 300 HCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQP 359
Query: 363 SQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPD-----FQEPLVSSGEEETL 417
S + P+S + L A LE +E + + P++ G +
Sbjct: 360 SAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSS 419
Query: 418 ILEEKQESQQTLSPTPGDPMLASWPTG 444
E+ E+ +TL M+ PTG
Sbjct: 420 TPEDPAEAPRTLLEFETQSMVP--PTG 444
>gi|38372935 brevican isoform 1 [Homo sapiens]
Length = 911
Score = 332 bits (851), Expect = 1e-90
Identities = 182/447 (40%), Positives = 256/447 (57%), Gaps = 17/447 (3%)
Query: 9 LGLLMLQMLLFVAGEQGTQDITD---ASERGLHMQKLGSGSVQAALAELVALPC-LFTLQ 64
L L +L L+ D+ + + +R ++ G +Q L + +PC + L+
Sbjct: 4 LFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLR 63
Query: 65 PRPS--AARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRAN 122
P PS A +PR+KWT + + ++ +LVA+ V+V ++++ RV+LP+YP +
Sbjct: 64 PPPSRRAVLGSPRVKWTFL----SRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTD 119
Query: 123 ATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEAC 182
+L L LR +DSG+YRC+V GI+D D V ++V GVVF YR RYA +F+ AQEAC
Sbjct: 120 VSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEAC 179
Query: 183 RLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGR 242
A IA P L AA+ G++ CDAGWLSD+TVRYPI R CYGD PGVR+YG
Sbjct: 180 ARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGV 239
Query: 243 RNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLD 302
+P +LYDVYC+A +L GE+F P +LTL ARA C+ +GA +A+ GQL+ AW GLD
Sbjct: 240 VDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLD 299
Query: 303 QCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPT 362
C PGWLADGSVRYPI TP +RCGG PGV+T++ F N+TGFP+ RF+ YCFR
Sbjct: 300 HCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQP 359
Query: 363 SQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPD-----FQEPLVSSGEEETL 417
S + P+S + L A LE +E + + P++ G +
Sbjct: 360 SAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSS 419
Query: 418 ILEEKQESQQTLSPTPGDPMLASWPTG 444
E+ E+ +TL M+ PTG
Sbjct: 420 TPEDPAEAPRTLLEFETQSMVP--PTG 444
Score = 294 bits (753), Expect = 3e-79
Identities = 185/527 (35%), Positives = 255/527 (48%), Gaps = 50/527 (9%)
Query: 791 DASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQV 850
+AS+P++ S G+ + VT LE E T + + P I E G
Sbjct: 364 EASNPASNPASDGLEAIVTVTETLEELQLPQEA-TESESRGAIYSIP-----IMEDGGGG 417
Query: 851 FEEAESTTLSPQVALD--TSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQ 908
E +P+ L+ T + P T + + + + E E++VE +
Sbjct: 418 SSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDE 477
Query: 909 GT----SGASVPPHQSSPLGKPAVPPGT-----------PTAASVGESASVSSGEPTVPW 953
S S P ++S +PA + P A+ + + S +S P V
Sbjct: 478 ALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHG 537
Query: 954 DPSSTL-----------LPVTLGIEDFELEVLAGSP---GVESFWEEVASGEEPA---LP 996
P+ TL P TL +E E+ G P GV E E A LP
Sbjct: 538 PPTETLPTPRERNLASPSPSTL-VEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLP 596
Query: 997 GTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYG---CSCDQGFAGENCEIDID-DCLC 1052
T G E+ + P E+N G T A ++ D G + DC+
Sbjct: 597 ATRAPEGTRELEA-PSEDNS---GRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVP 652
Query: 1053 SPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDA 1112
SPC NGGTC++E G CLCLP YGG C+ C+ GW FQG CY++F+ RR+WE+A
Sbjct: 653 SPCHNGGTCLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEA 712
Query: 1113 EKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWREN 1172
E CR HL S+ +PEE FIN+ E WIGLNDR +E DF W+D L +ENW
Sbjct: 713 ETQCRMYGAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPG 772
Query: 1173 QPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKA 1232
QPD++F GE+CVVMV H+ G+W+DVPCNY+L Y CK G V CGPPP + A + G +
Sbjct: 773 QPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRL 832
Query: 1233 KYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHR 1279
+Y V +RY+C EG AQ ++ IRC+ NG+W+ PQI C PRR R
Sbjct: 833 RYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCV-PRRPAR 878
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 328 bits (840), Expect = 3e-89
Identities = 161/315 (51%), Positives = 209/315 (66%), Gaps = 9/315 (2%)
Query: 47 VQAALAELVALPCLFT-----LQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVV 101
++ L + +PC F + PS A APRIKW++V + +++ +LVA + V
Sbjct: 39 LRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRV----SKEKEVVLLVATEGRV 94
Query: 102 RVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVV 161
RV ++Q +VSLP+YP ++ATL + LR++DSG+YRC+V+ GIED + + + V G+V
Sbjct: 95 RVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIV 154
Query: 162 FHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPIT 221
FHYR+ RY L F AQ AC +SAIIA P LQAA+EDGF CDAGWL+D+TVRYPI
Sbjct: 155 FHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH 214
Query: 222 QSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCR 281
R GCYGD+ PGVR+YG R+ E YDVYCFA E+ GEVFY + T A +CR
Sbjct: 215 TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECR 274
Query: 282 RQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANR 341
R GA LA+ GQL+LAW G+D C GWLAD SVRYPI R CGG GVRTVY AN+
Sbjct: 275 RLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQ 334
Query: 342 TGFPSPAERFDAYCF 356
TG+P P+ R+DA C+
Sbjct: 335 TGYPDPSSRYDAICY 349
Score = 313 bits (802), Expect = 7e-85
Identities = 210/636 (33%), Positives = 304/636 (47%), Gaps = 80/636 (12%)
Query: 708 TGETSPAQVNK-----AEHSSSSP--WPSVN---RNVAVGFVPTETATE----PTGLRGI 753
+GE+S A++ A + S +P +P+V+ R + TA E P+G+ +
Sbjct: 1791 SGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILEL 1850
Query: 754 PGSESGVFDTAESPT-----SGLQATVDEVQ-DPWPSVYSKGLDASSP------SAPLGS 801
G+ SG D + + SGLQ+ + E +P + Y G AS+ S +G+
Sbjct: 1851 SGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGT 1910
Query: 802 PGVFL-VPKVTPNLEPWVATDEGPTVNPM-----DSTVTPAPSDASGIWE---------- 845
G +P+VT +V PT++ T TP ++SG
Sbjct: 1911 SGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATP 1970
Query: 846 --PGS-----QVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPH 898
PGS V E + T+ P+ S + + G L ++S H
Sbjct: 1971 VLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSP-------DLSETTSAFH 2023
Query: 899 PEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVG-ESASVSSGEPTVPWDPSS 957
++ G SG+++ + P V + T + VG E+ + S PT D
Sbjct: 2024 EANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGD--R 2081
Query: 958 TLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPA-----LPGTPMNAGAEEVHSDPC 1012
T + L +L V+ + ES W + + PA + + + EE H+
Sbjct: 2082 TEISGDLSGHTSQLGVVISTSIPESEWTQQT--QRPAETHLEIESSSLLYSGEETHTVET 2139
Query: 1013 ENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLC 1072
+P + ++ + + C PC GTC + +CLC
Sbjct: 2140 ATSP--------TDASIPASPEWKRESESTAAAPARSCAEEPC-GAGTCKETEGHVICLC 2190
Query: 1073 LPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEH 1132
P Y G C D E C+ GW+K+QGHCYR+F R W DAE+ CR + HL+S+ +PEE
Sbjct: 2191 PPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQ 2250
Query: 1133 SFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHES 1192
F+N+ + WIGLNDR +E DF+W+D +QFENWR NQPDNFFA GEDCVVM+ HE
Sbjct: 2251 EFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEK 2310
Query: 1193 GRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHH 1252
G WNDVPCNY+LP+ CKKGTV CG PP VE+A G +K +Y +++ VRYQC EGF Q H
Sbjct: 2311 GEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRH 2370
Query: 1253 VATIRCRSNGKWDRPQIVCTKP-----RRSHRMRRH 1283
+ TIRC+ +G W+ PQI CT P R R RH
Sbjct: 2371 MPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRH 2406
Score = 262 bits (669), Expect = 2e-69
Identities = 238/754 (31%), Positives = 321/754 (42%), Gaps = 94/754 (12%)
Query: 159 GVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRY 218
GVVFHYR RY+LTF EAQ+AC + A+IA+P LQAA+E G++ CDAGWL D+TVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 219 PITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARA 278
PI R C GD+ S PGVR+YG R E YDVYCF L GEVF+ + T A
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 279 QCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRF 338
C A LA+ GQL+ AW GLD+C GWLADGS+RYPI TPR CGG PGVRTVY +
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 339 ANRTGFPSPAERFDAYCFR----AHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTL 394
N+TG P P R A+CFR P + G T SG E I++ P V + +
Sbjct: 657 PNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAV--PV 714
Query: 395 EEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASW-PTGEVW-LSTVA 452
EEE P + + E E + + + +P +L +W PTG ST
Sbjct: 715 EEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEG 774
Query: 453 PSPSDMGAGTAASSHTEVA-PTDPMPRRRGRFKGL----NGRYFQQQEPEPGLQGGMEAS 507
PS +++ + + S +EV P++ F + + F +EP P S
Sbjct: 775 PSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFP--------S 826
Query: 508 AQPPTSEAAVNQMEP----PLAMAVTEMLGSG-QSRSP--WADLTNEVDMPGAGSAGGKS 560
+P SE EP P + TE+ SG +S +P D T D+ G G+
Sbjct: 827 KEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQL 886
Query: 561 SPEPWLWPP----------TMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEAT 610
S + P + V + S P + E+ E PS TP + P A
Sbjct: 887 SGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPS----TPTVGELPSGAE 942
Query: 611 VSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWM-----LPHPTPISTEANRVE-----AH 660
+ S A V LP +L + LP + T A VE
Sbjct: 943 ILEGS-----ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPS 997
Query: 661 GEATATAPPS-------PAAETKVYSLP----LSLTPTGQGGEAMPTTPESPRADFRETG 709
GE T P P+ E + P +S P+G+ E T P +G
Sbjct: 998 GEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLET--TAPGVEDISGLPSG 1055
Query: 710 ETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSE------SGVFDT 763
E E S P G V TA + G+P E GV D
Sbjct: 1056 EVLETTAPGVEDISGLP---------SGEVLETTAPGVEDISGLPSGEVLETAAPGVEDI 1106
Query: 764 AESPTSG-LQATVDEVQDPWPSVYSKGLDASSPSAP--LGSPGVFLVPKVTPNLEPWVAT 820
+ P+ L+ V+D + L+ ++P G P ++ P +E
Sbjct: 1107 SGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGL 1166
Query: 821 DEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEA 854
G + T P D SG+ P +V E A
Sbjct: 1167 PSGEVL----ETAAPGVEDISGL--PSGEVLETA 1194
Score = 39.7 bits (91), Expect = 0.019
Identities = 100/408 (24%), Positives = 156/408 (38%), Gaps = 68/408 (16%)
Query: 642 WMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLS--------LTPTGQGGEA 693
++ P+ T + +R A +A PSP E P S +T G A
Sbjct: 654 YLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEG--GTPTSPSGVEEWIVTQVVPGVAA 711
Query: 694 MPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGI 753
+P E+ +GET+ E + + W + P T+ P L
Sbjct: 712 VPVEEETTAVP---SGETTAILEFTTEPENQTEWEPA-------YTPVGTSPLPGILPTW 761
Query: 754 PGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSA-PLGSPGVFLVPKVTP 812
P + + ++ E P++ + E +P PS + SPS P S F ++ P
Sbjct: 762 PPTGAATEESTEGPSATEVPSASE--EPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFP 819
Query: 813 NLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTP 872
+ EP+ + + P+ P S PS W EE+ + +S +
Sbjct: 820 SEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGH 879
Query: 873 LTTLEQ--GDKV-GVPA--------MSTLGS----SSSQPHPEPEDQVETQGT------- 910
L Q GD+ G+P+ ST+GS S P + E+++E T
Sbjct: 880 LDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGD-EERIEWPSTPTVGELP 938
Query: 911 SGASVPPHQSSPLGK-PAVPPG---TPTAASVGESASVSSG---EPTVPWD------PSS 957
SGA + +S +G +P G +A+ VG+ + + SG E T P PS
Sbjct: 939 SGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSG 998
Query: 958 TLLPVTL-GIEDF----ELEVL-AGSPGVESFWEEVASGE--EPALPG 997
+L T G+ED EVL +PGVE + SGE E PG
Sbjct: 999 EVLETTAPGVEDISGLPSGEVLETTAPGVEDI-SGLPSGEVLETTAPG 1045
Score = 35.4 bits (80), Expect = 0.36
Identities = 154/730 (21%), Positives = 250/730 (34%), Gaps = 118/730 (16%)
Query: 368 LETPSSGDE-------GEILSAEGPPVRELE--PTLEEEEVVTPDFQEPLVSSGEEETLI 418
LET + G E GE+L P V E+ P+ E E P +E SG +
Sbjct: 1286 LETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEE---ISGLPSGEV 1342
Query: 419 LEEKQESQQTLSPTP-----------GDPMLASWPTGEV------WLSTVAPSPSDMGAG 461
LE + LS P G ++ P+GEV + V+ PS G
Sbjct: 1343 LETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLE 1402
Query: 462 TAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQME 521
T+AS V +P + ++ F P G+E SA SE +
Sbjct: 1403 TSASG---VEDLSRLPSGEEVLE-ISASGFGDLSGLPSGGEGLETSA----SEVGTDLSG 1454
Query: 522 PPLAMAVTEMLGSGQSR-----SPWADL----TNEVDMPG--AGSAGGKSSPEPWLWPPT 570
P E SG S DL + ++D+ +G+ G +PE +
Sbjct: 1455 LPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPET-----S 1509
Query: 571 MVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLE-ATVSAPSPAPWEAFPVATSPD 629
+P SG ++ GP + PD P TVS E +T+ +
Sbjct: 1510 GLPSGFSGEYSG----VDLGSGPPS--GLPDFSGLPSGFPTVSLVDSTLVEVVTASTASE 1563
Query: 630 LPMMAML----RGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSL-PLSL 684
L + G + IS A+ + + E + A SP ++ L +S
Sbjct: 1564 LEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSG 1623
Query: 685 TPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETA 744
P+G + T+ + + + + + +S P+ + + VP + +
Sbjct: 1624 QPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVP-DLS 1682
Query: 745 TEPTGLRGIPGSESGVFDTAESPTSG----------------LQATVDEVQDPWPSVYSK 788
+P+GL G G+ SGV D TSG + T + ++ SV
Sbjct: 1683 GQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELS 1742
Query: 789 GLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDAS----GIW 844
GL + S V + + + ++ T + P + + S + ++S G
Sbjct: 1743 GLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSS 1802
Query: 845 EPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTL---GSSSSQPHPEP 901
P + ++ +D ++V +T + G L G+ S P
Sbjct: 1803 LPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSG 1862
Query: 902 EDQ--VETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPS--- 956
E ++ G + P PPGTP + S + SGE +V S
Sbjct: 1863 EHSGFLDLSGLQSGLIEP--------SGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA 1914
Query: 957 STLLPVTLGIEDFELEVLAGSPGVESFWEEVAS---GEEPALPGTPM---NAGAEEVHSD 1010
S L VTL +F VE E S G+ P + TP ++G D
Sbjct: 1915 SGLPEVTLITSEF----------VEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGD 1964
Query: 1011 PCENNPCLHG 1020
P L G
Sbjct: 1965 ISGATPVLPG 1974
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 4/88 (4%)
Query: 695 PTTPESPRADFRETGETSPAQVNKAEHSSSSPW--PSVNRNVAVGFVPTETATEPTGLRG 752
P PE P E G T+ A+V ++ PW P+ A F + + T + G
Sbjct: 411 PLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPG 470
Query: 753 IPGSESG-VFDTAESPTSGLQATVDEVQ 779
P G VF PT T +E Q
Sbjct: 471 QPHLPGGVVFHYRPGPTR-YSLTFEEAQ 497
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 328 bits (840), Expect = 3e-89
Identities = 161/315 (51%), Positives = 209/315 (66%), Gaps = 9/315 (2%)
Query: 47 VQAALAELVALPCLFT-----LQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVV 101
++ L + +PC F + PS A APRIKW++V + +++ +LVA + V
Sbjct: 39 LRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRV----SKEKEVVLLVATEGRV 94
Query: 102 RVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVV 161
RV ++Q +VSLP+YP ++ATL + LR++DSG+YRC+V+ GIED + + + V G+V
Sbjct: 95 RVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIV 154
Query: 162 FHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPIT 221
FHYR+ RY L F AQ AC +SAIIA P LQAA+EDGF CDAGWL+D+TVRYPI
Sbjct: 155 FHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH 214
Query: 222 QSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCR 281
R GCYGD+ PGVR+YG R+ E YDVYCFA E+ GEVFY + T A +CR
Sbjct: 215 TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECR 274
Query: 282 RQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANR 341
R GA LA+ GQL+LAW G+D C GWLAD SVRYPI R CGG GVRTVY AN+
Sbjct: 275 RLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQ 334
Query: 342 TGFPSPAERFDAYCF 356
TG+P P+ R+DA C+
Sbjct: 335 TGYPDPSSRYDAICY 349
Score = 262 bits (669), Expect = 2e-69
Identities = 238/754 (31%), Positives = 321/754 (42%), Gaps = 94/754 (12%)
Query: 159 GVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRY 218
GVVFHYR RY+LTF EAQ+AC + A+IA+P LQAA+E G++ CDAGWL D+TVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 219 PITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARA 278
PI R C GD+ S PGVR+YG R E YDVYCF L GEVF+ + T A
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 279 QCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRF 338
C A LA+ GQL+ AW GLD+C GWLADGS+RYPI TPR CGG PGVRTVY +
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 339 ANRTGFPSPAERFDAYCFR----AHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTL 394
N+TG P P R A+CFR P + G T SG E I++ P V + +
Sbjct: 657 PNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAV--PV 714
Query: 395 EEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASW-PTGEVW-LSTVA 452
EEE P + + E E + + + +P +L +W PTG ST
Sbjct: 715 EEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEG 774
Query: 453 PSPSDMGAGTAASSHTEVA-PTDPMPRRRGRFKGL----NGRYFQQQEPEPGLQGGMEAS 507
PS +++ + + S +EV P++ F + + F +EP P S
Sbjct: 775 PSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFP--------S 826
Query: 508 AQPPTSEAAVNQMEP----PLAMAVTEMLGSG-QSRSP--WADLTNEVDMPGAGSAGGKS 560
+P SE EP P + TE+ SG +S +P D T D+ G G+
Sbjct: 827 KEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQL 886
Query: 561 SPEPWLWPP----------TMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEAT 610
S + P + V + S P + E+ E PS TP + P A
Sbjct: 887 SGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPS----TPTVGELPSGAE 942
Query: 611 VSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWM-----LPHPTPISTEANRVE-----AH 660
+ S A V LP +L + LP + T A VE
Sbjct: 943 ILEGS-----ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPS 997
Query: 661 GEATATAPPS-------PAAETKVYSLP----LSLTPTGQGGEAMPTTPESPRADFRETG 709
GE T P P+ E + P +S P+G+ E T P +G
Sbjct: 998 GEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLET--TAPGVEDISGLPSG 1055
Query: 710 ETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSE------SGVFDT 763
E E S P G V TA + G+P E GV D
Sbjct: 1056 EVLETTAPGVEDISGLP---------SGEVLETTAPGVEDISGLPSGEVLETAAPGVEDI 1106
Query: 764 AESPTSG-LQATVDEVQDPWPSVYSKGLDASSPSAP--LGSPGVFLVPKVTPNLEPWVAT 820
+ P+ L+ V+D + L+ ++P G P ++ P +E
Sbjct: 1107 SGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGL 1166
Query: 821 DEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEA 854
G + T P D SG+ P +V E A
Sbjct: 1167 PSGEVL----ETAAPGVEDISGL--PSGEVLETA 1194
Score = 198 bits (504), Expect = 2e-50
Identities = 170/546 (31%), Positives = 234/546 (42%), Gaps = 85/546 (15%)
Query: 708 TGETSPAQVNK-----AEHSSSSP--WPSVN---RNVAVGFVPTETATE----PTGLRGI 753
+GE+S A++ A + S +P +P+V+ R + TA E P+G+ +
Sbjct: 1791 SGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILEL 1850
Query: 754 PGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPN 813
G+ SG D + +S LD S + L + P P
Sbjct: 1851 SGAHSGAPDMSGE-------------------HSGFLDLSGLQSGL------IEPSGEPP 1885
Query: 814 LEPWVATDEGPTVNPM-DSTVTPAPS-DASGIWEPG---SQVFEEAESTTLSPQVALDTS 868
P+ + D T N +S+V S +ASG+ E S+ E T+S ++
Sbjct: 1886 GTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPP 1945
Query: 869 IVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAV 928
+ E KV ST G S P VE +SVP S P
Sbjct: 1946 VTHTPQLFESSGKV-----STAGDISGATPVLPGSGVEV-----SSVPESSSETSAYPEA 1995
Query: 929 PPGTPTA--ASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGV------ 980
G A AS +S S E T + ++ LG+ L G
Sbjct: 1996 GFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSG 2055
Query: 981 ESFWEEVASGEEPALPG-TPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGF- 1038
ES E P LP TP +G D E + L G T G + S +
Sbjct: 2056 ESTTTSDVGTEAPGLPSATPTASG------DRTEISGDLSGHTSQL-GVVISTSIPESEW 2108
Query: 1039 -------AGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYG-----GSFCEKDTE 1086
A + EI+ L S E ++ +P+ D E
Sbjct: 2109 TQQTQRPAETHLEIESSSLLYSGEETH--TVETATSPTDASIPASPEWKRESESTAADQE 2166
Query: 1087 GCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIG 1146
C+ GW+K+QGHCYR+F R W DAE+ CR + HL+S+ +PEE F+N+ + WIG
Sbjct: 2167 VCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIG 2226
Query: 1147 LNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPY 1206
LNDR +E DF+W+D +QFENWR NQPDNFFA GEDCVVM+ HE G WNDVPCNY+LP+
Sbjct: 2227 LNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPF 2286
Query: 1207 VCKKGT 1212
CKKGT
Sbjct: 2287 TCKKGT 2292
Score = 39.7 bits (91), Expect = 0.019
Identities = 100/408 (24%), Positives = 156/408 (38%), Gaps = 68/408 (16%)
Query: 642 WMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLS--------LTPTGQGGEA 693
++ P+ T + +R A +A PSP E P S +T G A
Sbjct: 654 YLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEG--GTPTSPSGVEEWIVTQVVPGVAA 711
Query: 694 MPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGI 753
+P E+ +GET+ E + + W + P T+ P L
Sbjct: 712 VPVEEETTAVP---SGETTAILEFTTEPENQTEWEPA-------YTPVGTSPLPGILPTW 761
Query: 754 PGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSA-PLGSPGVFLVPKVTP 812
P + + ++ E P++ + E +P PS + SPS P S F ++ P
Sbjct: 762 PPTGAATEESTEGPSATEVPSASE--EPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFP 819
Query: 813 NLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTP 872
+ EP+ + + P+ P S PS W EE+ + +S +
Sbjct: 820 SEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGH 879
Query: 873 LTTLEQ--GDKV-GVPA--------MSTLGS----SSSQPHPEPEDQVETQGT------- 910
L Q GD+ G+P+ ST+GS S P + E+++E T
Sbjct: 880 LDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGD-EERIEWPSTPTVGELP 938
Query: 911 SGASVPPHQSSPLGK-PAVPPG---TPTAASVGESASVSSG---EPTVPWD------PSS 957
SGA + +S +G +P G +A+ VG+ + + SG E T P PS
Sbjct: 939 SGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSG 998
Query: 958 TLLPVTL-GIEDF----ELEVL-AGSPGVESFWEEVASGE--EPALPG 997
+L T G+ED EVL +PGVE + SGE E PG
Sbjct: 999 EVLETTAPGVEDISGLPSGEVLETTAPGVEDI-SGLPSGEVLETTAPG 1045
Score = 35.4 bits (80), Expect = 0.36
Identities = 154/730 (21%), Positives = 250/730 (34%), Gaps = 118/730 (16%)
Query: 368 LETPSSGDE-------GEILSAEGPPVRELE--PTLEEEEVVTPDFQEPLVSSGEEETLI 418
LET + G E GE+L P V E+ P+ E E P +E SG +
Sbjct: 1286 LETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEE---ISGLPSGEV 1342
Query: 419 LEEKQESQQTLSPTP-----------GDPMLASWPTGEV------WLSTVAPSPSDMGAG 461
LE + LS P G ++ P+GEV + V+ PS G
Sbjct: 1343 LETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLE 1402
Query: 462 TAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQME 521
T+AS V +P + ++ F P G+E SA SE +
Sbjct: 1403 TSASG---VEDLSRLPSGEEVLE-ISASGFGDLSGLPSGGEGLETSA----SEVGTDLSG 1454
Query: 522 PPLAMAVTEMLGSGQSR-----SPWADL----TNEVDMPG--AGSAGGKSSPEPWLWPPT 570
P E SG S DL + ++D+ +G+ G +PE +
Sbjct: 1455 LPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPET-----S 1509
Query: 571 MVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLE-ATVSAPSPAPWEAFPVATSPD 629
+P SG ++ GP + PD P TVS E +T+ +
Sbjct: 1510 GLPSGFSGEYSG----VDLGSGPPS--GLPDFSGLPSGFPTVSLVDSTLVEVVTASTASE 1563
Query: 630 LPMMAML----RGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSL-PLSL 684
L + G + IS A+ + + E + A SP ++ L +S
Sbjct: 1564 LEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSG 1623
Query: 685 TPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETA 744
P+G + T+ + + + + + +S P+ + + VP + +
Sbjct: 1624 QPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVP-DLS 1682
Query: 745 TEPTGLRGIPGSESGVFDTAESPTSG----------------LQATVDEVQDPWPSVYSK 788
+P+GL G G+ SGV D TSG + T + ++ SV
Sbjct: 1683 GQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELS 1742
Query: 789 GLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDAS----GIW 844
GL + S V + + + ++ T + P + + S + ++S G
Sbjct: 1743 GLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSS 1802
Query: 845 EPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTL---GSSSSQPHPEP 901
P + ++ +D ++V +T + G L G+ S P
Sbjct: 1803 LPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSG 1862
Query: 902 EDQ--VETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPS--- 956
E ++ G + P PPGTP + S + SGE +V S
Sbjct: 1863 EHSGFLDLSGLQSGLIEP--------SGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA 1914
Query: 957 STLLPVTLGIEDFELEVLAGSPGVESFWEEVAS---GEEPALPGTPM---NAGAEEVHSD 1010
S L VTL +F VE E S G+ P + TP ++G D
Sbjct: 1915 SGLPEVTLITSEF----------VEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGD 1964
Query: 1011 PCENNPCLHG 1020
P L G
Sbjct: 1965 ISGATPVLPG 1974
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 4/88 (4%)
Query: 695 PTTPESPRADFRETGETSPAQVNKAEHSSSSPW--PSVNRNVAVGFVPTETATEPTGLRG 752
P PE P E G T+ A+V ++ PW P+ A F + + T + G
Sbjct: 411 PLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPG 470
Query: 753 IPGSESG-VFDTAESPTSGLQATVDEVQ 779
P G VF PT T +E Q
Sbjct: 471 QPHLPGGVVFHYRPGPTR-YSLTFEEAQ 497
>gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo
sapiens]
Length = 360
Score = 234 bits (596), Expect = 5e-61
Identities = 135/308 (43%), Positives = 174/308 (56%), Gaps = 16/308 (5%)
Query: 55 VALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLP 114
V LPC + +P + R R+KW K+ +D +LVA R +QGRV L
Sbjct: 66 VILPCRYRYEPALVSPRRV-RVKWWKLSENGAPEKD--VLVAIGLRHRSFGDYQGRVHLR 122
Query: 115 SYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALT 174
+ + +L + LR D G YRC+V+ G+EDE LV LE+ GVVF Y+S RY
Sbjct: 123 Q--DKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFN 180
Query: 175 FAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSL 234
F E Q+ C +A++A+ L A+E+G D C+AGWL D TV+YPI R C G
Sbjct: 181 FHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPC-GGPGLA 239
Query: 235 PGVRSYGRRNPQ-ELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQL 293
PGVRSYG R+ + YDV+CFA L G V+Y+ +LTL AR C+ A +A VGQL
Sbjct: 240 PGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQL 299
Query: 294 HLAW-HEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAER-F 351
AW GLD+CD GWLADGSVRYP+ P CG P PGVR+ GFP P R +
Sbjct: 300 FAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF-------GFPDPQSRLY 352
Query: 352 DAYCFRAH 359
YC+R H
Sbjct: 353 GVYCYRQH 360
>gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo
sapiens]
Length = 402
Score = 222 bits (565), Expect = 2e-57
Identities = 137/372 (36%), Positives = 190/372 (51%), Gaps = 27/372 (7%)
Query: 1 MGAPFVWALGLLMLQMLLFVAGEQGTQDITDA--SERGLHMQKLGSGSVQAALAELVALP 58
+G +WA +L + ++G + + E G + + G V + + LP
Sbjct: 8 LGPGALWAAAWGVLLLTAPAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLP 67
Query: 59 CLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPR 118
C + + + D R+KWTKV + VA R S++GR L
Sbjct: 68 CRYHYEAA-AHGHDGVRLKWTKVVDPLAFTD---VFVALGPQHRAFGSYRGRAELQG--D 121
Query: 119 RRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEA 178
+A+L+L + D G Y C+V +ED+ +V L++ GVVF Y RY LTFAEA
Sbjct: 122 GPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKLTFAEA 181
Query: 179 QEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGC---------YG 229
Q AC I+A+ L AA+ DG D C+AGWL D +V+YP+ + R C G
Sbjct: 182 QRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPCGGLGGTGSAGG 241
Query: 230 DRSSLPGVRSYG-RRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALA 288
+ G+R+YG R N +E YD +CF L G VF++ P R + +GA C +GAA+A
Sbjct: 242 GGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAVA 301
Query: 289 SVGQLHLAWH-EGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSP 347
VGQL AW + LD+C GWLADGS RYPI PR RCGG PGVR++ GFP
Sbjct: 302 KVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSL-------GFPDA 354
Query: 348 AER-FDAYCFRA 358
R F YC+RA
Sbjct: 355 TRRLFGVYCYRA 366
Score = 81.6 bits (200), Expect = 4e-15
Identities = 48/114 (42%), Positives = 60/114 (52%), Gaps = 9/114 (7%)
Query: 257 ELGGEVFYVGPAR---RLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGS 313
+L G VF P +LT A A+ C Q LAS QLH AW +GLD C+ GWL DGS
Sbjct: 159 DLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGS 218
Query: 314 VRYPIQTPRRRCGG-----PAPGVRTVYRFANRTGFPSPAE-RFDAYCFRAHHP 361
V+YP+ PR CGG A G G+ AE R+DA+CF ++ P
Sbjct: 219 VQYPVNRPREPCGGLGGTGSAGGGGDANGGLRNYGYRHNAEERYDAFCFTSNLP 272
>gi|11141887 brain link protein-1 [Homo sapiens]
Length = 340
Score = 216 bits (550), Expect = 1e-55
Identities = 127/304 (41%), Positives = 176/304 (57%), Gaps = 25/304 (8%)
Query: 57 LPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSY 116
LPC+ P PS +++W+KV G+ ++ IL+ R GR +
Sbjct: 55 LPCVLGTTP-PSY-----KVRWSKVEP--GELRETLILITNGLHARGYGPLGGRARMRR- 105
Query: 117 PRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFA 176
R +A+L++ +R D G YRC+++ GIEDE + L + GVVF Y+ +R RY +
Sbjct: 106 -GHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYY 164
Query: 177 EAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPG 236
EA++AC +A L A+ +G D C+AGWL + +VRYP+ +R C G PG
Sbjct: 165 EAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGG--RGRPG 222
Query: 237 VRSYGRRN-PQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHL 295
+RSYG R+ ++ YD +CF L G+VF+V RLTL+ A A CRR+GA +A VG L+
Sbjct: 223 IRSYGPRDRMRDRYDAFCFTSALAGQVFFV--PGRLTLSEAHAACRRRGAVVAKVGHLYA 280
Query: 296 AW-HEGLDQCDPGWLADGSVRYPIQTPRRRCGG-PAPGVRTVYRFANRTGFPSPAE-RFD 352
AW GLDQCD GWLADGSVR+PI TPR RCGG P PGVR+ GFP P + +
Sbjct: 281 AWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSF-------GFPRPQQAAYG 333
Query: 353 AYCF 356
YC+
Sbjct: 334 TYCY 337
>gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo
sapiens]
Length = 354
Score = 210 bits (534), Expect = 8e-54
Identities = 135/363 (37%), Positives = 194/363 (53%), Gaps = 25/363 (6%)
Query: 11 LLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGS--VQAALAEL-------VALPCLF 61
LL+L ++ + + + T +R +H+Q V+A A++ V LPC F
Sbjct: 4 LLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKF 63
Query: 62 TLQPRP-SAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR 120
P + RIKWTK+ S +++ + V+ + +QGRV L
Sbjct: 64 YRDPTAFGSGIHKIRIKWTKL--TSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKG--GSD 119
Query: 121 ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE 180
++A+L++ L D G Y+C+V+ G+ED+ +V L++ GVVF Y RY L F EAQ+
Sbjct: 120 SDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQ 179
Query: 181 ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY 240
AC A+IA+ L A+ G D C+AGWLSD +V+YPIT+ R C G ++++PGVR+Y
Sbjct: 180 ACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPC-GGQNTVPGVRNY 238
Query: 241 G-RRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWH- 298
G + YDV+CF G +Y+ +LT A C GA +A VGQ+ AW
Sbjct: 239 GFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKI 298
Query: 299 EGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAER-FDAYCFR 357
G D+CD GWLADGSVRYPI PRRRC VR V GFP + + YCFR
Sbjct: 299 LGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFV-------GFPDKKHKLYGVYCFR 351
Query: 358 AHH 360
A++
Sbjct: 352 AYN 354
>gi|110624774 mannose receptor, C type 2 [Homo sapiens]
Length = 1479
Score = 122 bits (305), Expect = 3e-27
Identities = 56/126 (44%), Positives = 77/126 (61%), Gaps = 4/126 (3%)
Query: 1088 CDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFIN---SFGHENTW 1144
C+ W FQGHCYR A +R+W++++K C R G L S+HS E FI E W
Sbjct: 382 CEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELW 441
Query: 1145 IGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNL 1204
IGLND ++ +F+W+D + + F +W +P+NF EDCV + E GRWND PCN +L
Sbjct: 442 IGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPE-GRWNDSPCNQSL 500
Query: 1205 PYVCKK 1210
P +CKK
Sbjct: 501 PSICKK 506
Score = 94.4 bits (233), Expect = 7e-19
Identities = 53/151 (35%), Positives = 76/151 (50%), Gaps = 12/151 (7%)
Query: 1070 CLCLPSYGGS----FCEKDTEGCDRGWHKFQ--GHCYRY-FAHRRAWEDAEKDCRRRSGH 1122
C YG FC + C+ W K Q CY++ F +W +A C ++
Sbjct: 213 CATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGAD 272
Query: 1123 LTSVHSPEEHSFINSF--GHENT-WIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFA 1179
L S+ E ++IN G+ +T WIGLND +QW+DN+ L++ NW +QPDN
Sbjct: 273 LLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDN--P 330
Query: 1180 GGEDCVVMVAHESGRWNDVPCNYNLPYVCKK 1210
E+C V+ SG W + C+ LPYVCKK
Sbjct: 331 SEENCGVIRTESSGGWQNRDCSIALPYVCKK 361
Score = 75.1 bits (183), Expect = 4e-13
Identities = 44/133 (33%), Positives = 63/133 (47%), Gaps = 13/133 (9%)
Query: 1090 RGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFI-------NSFGHEN 1142
R W +FQ Y++F H W A++ C LTSVHS E F+ + ++
Sbjct: 827 REWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQH 886
Query: 1143 TWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGED--CVVMVAHESGRWNDVPC 1200
WIGL+ + F+WTD + + F +W +P G+D CV M A W D C
Sbjct: 887 WWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPV---GKDKKCVYMTASRED-WGDQRC 942
Query: 1201 NYNLPYVCKKGTV 1213
LPY+CK+ V
Sbjct: 943 LTALPYICKRSNV 955
Score = 67.0 bits (162), Expect = 1e-10
Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 19/143 (13%)
Query: 1087 GCDRGWHKFQGHCYRYFAH----RRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHEN 1142
GC W +F C++ R W +A+ C ++ L ++ +P E +FI +
Sbjct: 971 GCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNV 1030
Query: 1143 T---WIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGE-----DCVVMV----AH 1190
T WIGL+ +RDFQW + L + NW +P C V++ AH
Sbjct: 1031 TFDLWIGLHAS--QRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAH 1088
Query: 1191 ESGRWNDVPCNYNL-PYVCKKGT 1212
+GRW+D C ++C+KGT
Sbjct: 1089 FTGRWDDRSCTEETHGFICQKGT 1111
Score = 50.8 bits (120), Expect = 8e-06
Identities = 47/201 (23%), Positives = 80/201 (39%), Gaps = 24/201 (11%)
Query: 1083 KDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH-- 1140
++ GC +GW CY + + +A + C L ++ + E +F++S +
Sbjct: 516 EEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNW 575
Query: 1141 --ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHES-GRWND 1197
E W L D F W + + +W +QP + GG CV + + G W
Sbjct: 576 EGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQP-GYSRGG--CVALATGSAMGLWEV 632
Query: 1198 VPC-NYNLPYVCKK--GT----VLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQ 1250
C ++ Y+C++ GT L GP P SL G+ + +RY C + F+
Sbjct: 633 KNCTSFRARYICRQSLGTPVTPELPGPDP---TPSLTGSCPQGWASDTKLRY-CYKVFSS 688
Query: 1251 HHVATIRCRSNGKWDRPQIVC 1271
R + W + Q C
Sbjct: 689 E-----RLQDKKSWVQAQGAC 704
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 12/143 (8%)
Query: 1075 SYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRR-AWEDAEKDCRRRSGHLTSVHSPEEHS 1133
SY GS C + D W F+ HCY + ++A + C+R G + S+ E+
Sbjct: 1256 SYHGS-CPQGL--ADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENV 1312
Query: 1134 FI----NSFGHEN--TWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVM 1187
F+ S+ ++ W+G+N W DNT + + NW C
Sbjct: 1313 FVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSC-YW 1371
Query: 1188 VAHESGRWNDVPC-NYNLPYVCK 1209
+ SG W C N + VCK
Sbjct: 1372 IQSNSGLWRPGACTNITMGVVCK 1394
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/170 (24%), Positives = 58/170 (34%), Gaps = 25/170 (14%)
Query: 1060 TCIDEVNGFVCL------CLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAE 1113
+C +E +GF+C PS TE + +R W DA
Sbjct: 1097 SCTEETHGFICQKGTDPSLSPSPAALPPAPGTE------LSYLNGTFRLLQKPLRWHDAL 1150
Query: 1114 KDCRRRSGHLTSVHSPEEHSFINSFGH---ENTWIGLNDRIVERDFQWTDNTGLQFENWR 1170
C R+ L V P +F+ WIGL R + W L + W+
Sbjct: 1151 LLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQ 1210
Query: 1171 ENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLP-YVCKKGTVLCGPPP 1219
+ +P GG C + G W C+ L VC V GPPP
Sbjct: 1211 DGEPQQ--PGG--CTYV--DVDGAWRTTSCDTKLQGAVC---GVSSGPPP 1251
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 99.8 bits (247), Expect = 2e-20
Identities = 43/92 (46%), Positives = 53/92 (57%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E D C +NPC HG TC+ Y C C G+ G NCE ++D+C PC+NGGTCID V
Sbjct: 1147 EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLV 1206
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQG 1097
N F C C P G CE++ + C RG H G
Sbjct: 1207 NHFKCSCPPGTRGLLCEENIDDCARGPHCLNG 1238
Score = 99.4 bits (246), Expect = 2e-20
Identities = 43/93 (46%), Positives = 55/93 (59%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C + PC++ G C+ Y C C GF+G +CE DIDDCL +PC+NGG+C+D VN F
Sbjct: 875 DECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFS 934
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRY 1102
CLCLP + G C+ D C K G C Y
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDY 967
Score = 90.5 bits (223), Expect = 1e-17
Identities = 35/84 (41%), Positives = 49/84 (58%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ + C++NPC++ G C + C C GF G C+IDIDDC +PC NG CID
Sbjct: 492 ELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHP 551
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCD 1089
NG+ C C + G CE++ + CD
Sbjct: 552 NGYECQCATGFTGVLCEENIDNCD 575
Score = 90.1 bits (222), Expect = 1e-17
Identities = 35/83 (42%), Positives = 52/83 (62%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV + C +NPC +GGTC+ Y C+C +GF G NC+++ID+C +PC N GTC D++
Sbjct: 755 EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDI 814
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+G+ C C+ Y G C+ C
Sbjct: 815 SGYTCHCVLPYTGKNCQTVLAPC 837
Score = 89.0 bits (219), Expect = 3e-17
Identities = 36/79 (45%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 1011 PCENNPCLHGGTCNANGTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
PC +PC++GGTC G + C+C GF G CE +IDDC C+NGG C+D VN +
Sbjct: 224 PCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYN 283
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C P + G FC +D + C
Sbjct: 284 CRCPPQWTGQFCTEDVDEC 302
Score = 88.6 bits (218), Expect = 4e-17
Identities = 34/86 (39%), Positives = 48/86 (55%)
Query: 1014 NNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCL 1073
+NPC H G C + C C +G+AG CE+DI++C PC+N TC+D++ GF CLC+
Sbjct: 424 SNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM 483
Query: 1074 PSYGGSFCEKDTEGCDRGWHKFQGHC 1099
P + G CE + C G C
Sbjct: 484 PGFKGVHCELEINECQSNPCVNNGQC 509
Score = 87.4 bits (215), Expect = 8e-17
Identities = 37/89 (41%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +NPC+HG C + Y C CD G+ G NCE+D ++CL +PC+NGGTC + VNG+ C
Sbjct: 724 CLSNPCIHGN-CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCT 782
Query: 1072 CLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
C + G C+ + + C QG C+
Sbjct: 783 CKKGFKGYNCQVNIDECASNPCLNQGTCF 811
Score = 86.7 bits (213), Expect = 1e-16
Identities = 33/79 (41%), Positives = 45/79 (56%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C NPC +GG+C + C C GF G+ C+ D+++CL PC+NGGTC D VN +
Sbjct: 913 DDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYT 972
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C + G CE + C
Sbjct: 973 CKCQAGFDGVHCENNINEC 991
Score = 85.1 bits (209), Expect = 4e-16
Identities = 35/77 (45%), Positives = 46/77 (59%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C + PC +GGTC+ Y C C GF G +CE +I++C S C NGGTC+D +N F CL
Sbjct: 953 CLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCL 1012
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C + GSFC + C
Sbjct: 1013 CPVGFTGSFCLHEINEC 1029
Score = 83.6 bits (205), Expect = 1e-15
Identities = 33/67 (49%), Positives = 42/67 (62%), Gaps = 1/67 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E++ D C +NPC+HG C Y C C GF G+ C IDID+C +PC G TCI+ V
Sbjct: 643 EINFDDCASNPCIHG-ICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGV 701
Query: 1066 NGFVCLC 1072
NGF C+C
Sbjct: 702 NGFRCIC 708
Score = 82.4 bits (202), Expect = 3e-15
Identities = 35/83 (42%), Positives = 49/83 (59%), Gaps = 5/83 (6%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E HSDPC+N+ TC + C C GF G +CE++I++C +PC N G C+D+V
Sbjct: 459 ECHSDPCQND-----ATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKV 513
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
N F CLC P + G C+ D + C
Sbjct: 514 NRFQCLCPPGFTGPVCQIDIDDC 536
Score = 79.7 bits (195), Expect = 2e-14
Identities = 40/93 (43%), Positives = 48/93 (51%), Gaps = 8/93 (8%)
Query: 1009 SDPC-ENNPCLHGGTCNA-NGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN 1066
S PC + PCL+GGTC+ + Y C+C GF G+ C+ D CL PC NG TC N
Sbjct: 106 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 164
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
F C CL + G CE D CD GHC
Sbjct: 165 QFSCKCLTGFTGQKCETDVNECD-----IPGHC 192
Score = 77.0 bits (188), Expect = 1e-13
Identities = 32/79 (40%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C ++PCL+ G C Y C+C G +G NCEI+ DDC +PC + G C+D +N +
Sbjct: 609 DECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIH-GICMDGINRYS 667
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C+C P + G C D + C
Sbjct: 668 CVCSPGFTGQRCNIDIDEC 686
Score = 77.0 bits (188), Expect = 1e-13
Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 2/80 (2%)
Query: 1011 PCENNPCLHGGTC--NANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGF 1068
PC NPC + C + N Y C C G+ G+ C IDID+C+ PC N G C + +
Sbjct: 836 PCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSY 895
Query: 1069 VCLCLPSYGGSFCEKDTEGC 1088
+C C P + G CE+D + C
Sbjct: 896 MCECPPGFSGMDCEEDIDDC 915
Score = 76.6 bits (187), Expect = 1e-13
Identities = 35/83 (42%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E + D C+ +PC H G C Y C C+ G+ G C ID+C SPC N G CID V
Sbjct: 568 EENIDNCDPDPC-HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLV 626
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
NG+ C C P G CE + + C
Sbjct: 627 NGYQCNCQPGTSGVNCEINFDDC 649
Score = 76.3 bits (186), Expect = 2e-13
Identities = 31/89 (34%), Positives = 44/89 (49%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C H G C G + C C G+ G CE +D+C +PC++G TC D + G+ C C+P Y
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179
Query: 1077 GGSFCEKDTEGCDRGWHKFQGHCYRYFAH 1105
G CE + + C + G C H
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNH 1208
Score = 75.5 bits (184), Expect = 3e-13
Identities = 30/78 (38%), Positives = 45/78 (57%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C ++PCL+ GTC Y CSC G+ G+NC+ ++ C SPC+N GTC+ + CL
Sbjct: 1029 CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL 1088
Query: 1072 CLPSYGGSFCEKDTEGCD 1089
C + G++C+ CD
Sbjct: 1089 CPSGWAGAYCDVPNVSCD 1106
Score = 75.1 bits (183), Expect = 4e-13
Identities = 33/84 (39%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 1010 DPCENNPCLHGGTCNAN--GTMYGCSCDQGFAGENCEIDIDDCL---CSPCENGGTCIDE 1064
D C +NPC G C+ N Y C+C QG+ G +C D+D+C +PCE+ G C++
Sbjct: 377 DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNT 436
Query: 1065 VNGFVCLCLPSYGGSFCEKDTEGC 1088
F C CL Y G CE D C
Sbjct: 437 DGAFHCECLKGYAGPRCEMDINEC 460
Score = 74.7 bits (182), Expect = 5e-13
Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP--CENGGTCID 1063
E + D C N+ C +GG C Y C C + G+ C D+D+CL P C+NGGTC +
Sbjct: 258 ERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCAN 317
Query: 1064 EVNGFVCLCLPSYGGSFCEKDTEGC 1088
G+ C+C+ + G C ++ + C
Sbjct: 318 RNGGYGCVCVNGWSGDDCSENIDDC 342
Score = 74.3 bits (181), Expect = 7e-13
Identities = 34/90 (37%), Positives = 44/90 (48%)
Query: 1005 EEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDE 1064
E+V + N C +GGTC YGC C G++G++C +IDDC + C G TCID
Sbjct: 297 EDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDR 356
Query: 1065 VNGFVCLCLPSYGGSFCEKDTEGCDRGWHK 1094
V F C+C G C D HK
Sbjct: 357 VASFSCMCPEGKAGLLCHLDDACISNPCHK 386
Score = 74.3 bits (181), Expect = 7e-13
Identities = 35/86 (40%), Positives = 48/86 (55%), Gaps = 3/86 (3%)
Query: 1006 EVHSDPCENNP-CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGT--CI 1062
E + D C P CL+GG C Y C C GFAGE CE DI++CL +PC + G+ CI
Sbjct: 1223 EENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCI 1282
Query: 1063 DEVNGFVCLCLPSYGGSFCEKDTEGC 1088
N ++C+C ++ G CE + C
Sbjct: 1283 QLTNDYLCVCRSAFTGRHCETFVDVC 1308
Score = 73.6 bits (179), Expect = 1e-12
Identities = 30/83 (36%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
++ D C + PCL+G C + Y C C GF G CE +ID+C PC + G C D +
Sbjct: 530 QIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHH-GQCQDGI 588
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+ + C+C P Y G+ C + C
Sbjct: 589 DSYTCICNPGYMGAICSDQIDEC 611
Score = 72.0 bits (175), Expect = 4e-12
Identities = 31/85 (36%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
+V+ D C +NPCL+ GTC + + Y C C + G+NC+ + C +PCEN C +
Sbjct: 793 QVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESP 852
Query: 1066 N--GFVCLCLPSYGGSFCEKDTEGC 1088
N + CLC P + G C D + C
Sbjct: 853 NFESYTCLCAPGWQGQRCTIDIDEC 877
Score = 72.0 bits (175), Expect = 4e-12
Identities = 40/124 (32%), Positives = 55/124 (44%), Gaps = 12/124 (9%)
Query: 1002 AGAEEVHSD----PCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCEN 1057
AG + VH + C + C +GGTC + C C GF G C +I++C PC N
Sbjct: 977 AGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLN 1036
Query: 1058 GGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCR 1117
GTC+D + + C C Y G C+ C R K +G C + + AE C
Sbjct: 1037 EGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQ--------KKAESQCL 1088
Query: 1118 RRSG 1121
SG
Sbjct: 1089 CPSG 1092
Score = 71.6 bits (174), Expect = 5e-12
Identities = 27/81 (33%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 1003 GAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDC-LCSPCENGGTC 1061
G E +D C ++PC +G TC + C C GF G+ CE D+++C + C++GGTC
Sbjct: 139 GKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC 198
Query: 1062 IDEVNGFVCLCLPSYGGSFCE 1082
++ + C C + G +C+
Sbjct: 199 LNLPGSYQCQCPQGFTGQYCD 219
Score = 71.2 bits (173), Expect = 6e-12
Identities = 33/73 (45%), Positives = 40/73 (54%), Gaps = 1/73 (1%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN-GFVCLCLPS 1075
C HGGTC Y C C QGF G+ C+ C SPC NGGTC + F C CLP
Sbjct: 192 CQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPG 251
Query: 1076 YGGSFCEKDTEGC 1088
+ GS CE++ + C
Sbjct: 252 FEGSTCERNIDDC 264
Score = 54.3 bits (129), Expect = 8e-07
Identities = 31/88 (35%), Positives = 44/88 (50%), Gaps = 8/88 (9%)
Query: 1004 AEEVHSDPCENN--PCLHGGTCNA--NGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGG 1059
A H+ C + PC++ G C NGT Y C C +GF GE C+ D C + C+NGG
Sbjct: 20 AAPAHALQCRDGYEPCVNEGMCVTYHNGTGY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGG 77
Query: 1060 TCIDE--VNGFVCLCLPSYGGSFCEKDT 1085
TC+ + + C C + G C+ T
Sbjct: 78 TCVAQAMLGKATCRCASGFTGEDCQYST 105
Score = 52.0 bits (123), Expect = 4e-06
Identities = 31/111 (27%), Positives = 41/111 (36%), Gaps = 34/111 (30%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTM---YGCSCDQGFAGENCEIDI--------------- 1047
E D C PCL+GGTC M + C C GF+G C+
Sbjct: 1302 ETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTA 1361
Query: 1048 --------------DDCLCSPCENGGTCIDEVNG--FVCLCLPSYGGSFCE 1082
C SPC++GG+C + + C C P + GS CE
Sbjct: 1362 SGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE 1412
Score = 39.3 bits (90), Expect = 0.025
Identities = 21/71 (29%), Positives = 29/71 (40%), Gaps = 12/71 (16%)
Query: 1012 CENNPCLHGGTCN--ANGTMYGCSCDQGFAGENCEI-------DIDDCL---CSPCENGG 1059
C ++PC HGG+C+ Y C C F+G CE+ CL C+ G
Sbjct: 1378 CASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDG 1437
Query: 1060 TCIDEVNGFVC 1070
C + N C
Sbjct: 1438 VCDEACNSHAC 1448
Score = 33.5 bits (75), Expect = 1.4
Identities = 48/243 (19%), Positives = 89/243 (36%), Gaps = 29/243 (11%)
Query: 454 SPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTS 513
SP AG+ + H P D M R N + P G G+ ++PP
Sbjct: 2232 SPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEG 2291
Query: 514 EAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLW--PPTM 571
+ EP + +++ G P P + + P P ++ P
Sbjct: 2292 KHITTPREPLPPIVTFQLIPKGSIAQPAG-----APQPQSTCPPAVAGPLPTMYQIPEMA 2346
Query: 572 VPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSA-PSPAPWEAFPVATSPDL 630
PS++ P + + +G A+ P + P A+V P+P ++ + + +
Sbjct: 2347 RLPSVA----FPTAMMPQQDGQVAQTILP--AYHPFPASVGKYPTPPSQHSYASSNAAER 2400
Query: 631 --PMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTG 688
L+G ++ P P E+ + ++++P S + + V + P TP G
Sbjct: 2401 TPSHSGHLQGEHPYLTPSP----------ESPDQWSSSSPHSASDWSDVTTSP---TPGG 2447
Query: 689 QGG 691
GG
Sbjct: 2448 AGG 2450
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 97.1 bits (240), Expect = 1e-19
Identities = 39/83 (46%), Positives = 50/83 (60%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV + C +PC HG +C Y C C G++G NCE DIDDC +PC NGG+C D +
Sbjct: 867 EVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGI 926
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
N C CLP + G+FCE+D C
Sbjct: 927 NTAFCDCLPGFRGTFCEEDINEC 949
Score = 95.1 bits (235), Expect = 4e-19
Identities = 39/94 (41%), Positives = 60/94 (63%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
+++++ CE+NPC++GGTC + Y C+C +GF+G NC+ +I++C +PC N GTCID+V
Sbjct: 751 DINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV 810
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
G+ C CL Y G+ CE C + G C
Sbjct: 811 AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGEC 844
Score = 94.0 bits (232), Expect = 9e-19
Identities = 35/84 (41%), Positives = 50/84 (59%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV++D C ++PCLH G C + C C GF G C+ D+D+C +PC+NG C+D
Sbjct: 488 EVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGP 547
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCD 1089
N + C+C Y G+ CE D + CD
Sbjct: 548 NTYTCVCTEGYTGTHCEVDIDECD 571
Score = 93.6 bits (231), Expect = 1e-18
Identities = 37/83 (44%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E + + C + PC HGGTC Y C C +G G NCEI++DDC SPC++ GTC+D++
Sbjct: 601 ETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDS-GTCLDKI 659
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+G+ C C P Y GS C + + C
Sbjct: 660 DGYECACEPGYTGSMCNINIDEC 682
Score = 90.9 bits (224), Expect = 7e-18
Identities = 36/79 (45%), Positives = 51/79 (64%), Gaps = 1/79 (1%)
Query: 1011 PCENNPCLHGGTCNANGTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
PC +PC +GGTC G + + C+C GF G+NCE +IDDC + C+NGG C+D VN +
Sbjct: 221 PCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYN 280
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C P + G +C +D + C
Sbjct: 281 CRCPPEWTGQYCTEDVDEC 299
Score = 90.5 bits (223), Expect = 1e-17
Identities = 39/95 (41%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 995 LPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP 1054
LPG E+++ C ++PC +G C Y C+C GF+G +CE + DC S
Sbjct: 934 LPGFRGTFCEEDINE--CASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESS 991
Query: 1055 CENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCD 1089
C NGGTC+D +N F CLC P + GS+C+ D CD
Sbjct: 992 CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECD 1026
Score = 89.7 bits (221), Expect = 2e-17
Identities = 34/85 (40%), Positives = 49/85 (57%)
Query: 1015 NPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLP 1074
NPC H G C + C C QG+ G CEID+++C+ +PC+N TC+D++ F C+C+P
Sbjct: 421 NPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP 480
Query: 1075 SYGGSFCEKDTEGCDRGWHKFQGHC 1099
Y G CE +T+ C G C
Sbjct: 481 GYEGVHCEVNTDECASSPCLHNGRC 505
Score = 83.6 bits (205), Expect = 1e-15
Identities = 35/88 (39%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +NPC+HG C + Y C CD G++G NC+I+ ++C +PC NGGTC D +G+VC
Sbjct: 720 CNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778
Query: 1072 CLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
C + G C+ + C QG C
Sbjct: 779 CREGFSGPNCQTNINECASNPCLNQGTC 806
Score = 82.0 bits (201), Expect = 3e-15
Identities = 34/84 (40%), Positives = 47/84 (55%), Gaps = 1/84 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E++ D C ++PC GTC Y C+C+ G+ G C I+ID+C +PC NGGTC D +
Sbjct: 639 EINLDDCASSPC-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGI 697
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCD 1089
NGF C C Y C + C+
Sbjct: 698 NGFTCRCPEGYHDPTCLSEVNECN 721
Score = 79.7 bits (195), Expect = 2e-14
Identities = 33/80 (41%), Positives = 44/80 (55%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +PC +G TC Y C C G+ G NC +ID+CL PC+NGGTC+D N +
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYK 1206
Query: 1070 CLCLPSYGGSFCEKDTEGCD 1089
C C G CE + + C+
Sbjct: 1207 CSCPRGTQGVHCEINVDDCN 1226
Score = 79.0 bits (193), Expect = 3e-14
Identities = 33/83 (39%), Positives = 41/83 (49%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E D C NPC +GG+C C C GF G CE DI++C PC NG C D V
Sbjct: 905 ETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCV 964
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+ + C C + G CE +T C
Sbjct: 965 DSYTCTCPAGFSGIHCENNTPDC 987
Score = 78.6 bits (192), Expect = 4e-14
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C + PC +G C Y C C +G+ G +CE+DID+C PC + G+C D V F
Sbjct: 530 DECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFT 588
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
CLC P Y G CE + C + G C
Sbjct: 589 CLCRPGYTGHHCETNINECSSQPCRHGGTC 618
Score = 78.6 bits (192), Expect = 4e-14
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 999 PMNAGAEEVHSDPCENNPCLHGGTCNANGTM--YGCSCDQGFAGENCEIDIDDCLCSPCE 1056
P EV PC +PC +GG C + + C C G+ G+ CE+DI++C+ SPC
Sbjct: 820 PYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCR 879
Query: 1057 NGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
+G +C + G+ C C Y G CE D + C
Sbjct: 880 HGASCQNTHGGYRCHCQAGYSGRNCETDIDDC 911
Score = 77.8 bits (190), Expect = 6e-14
Identities = 32/83 (38%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV D C+ +PC H G+C + C C G+ G +CE +I++C PC +GGTC D
Sbjct: 564 EVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRD 622
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
N ++C CL G CE + + C
Sbjct: 623 NAYLCFCLKGTTGPNCEINLDDC 645
Score = 76.3 bits (186), Expect = 2e-13
Identities = 30/78 (38%), Positives = 43/78 (55%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C++ PCLHGGTC Y C+C QG+ G NC+ + C SPC+NGG C + C
Sbjct: 1025 CDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCE 1084
Query: 1072 CLPSYGGSFCEKDTEGCD 1089
C + G +C+ + C+
Sbjct: 1085 CPSGWTGLYCDVPSVSCE 1102
Score = 75.9 bits (185), Expect = 2e-13
Identities = 29/83 (34%), Positives = 46/83 (55%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ + C +NPC + TC + C C G+ G +CE++ D+C SPC + G C+D++
Sbjct: 450 EIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI 509
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
N F C C + G C+ D + C
Sbjct: 510 NEFQCECPTGFTGHLCQYDVDEC 532
Score = 75.9 bits (185), Expect = 2e-13
Identities = 29/72 (40%), Positives = 40/72 (55%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C HGG C G + C C G+ G CE +D+C SPC+NG TC D + G+ C C+ Y
Sbjct: 1116 CQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGY 1175
Query: 1077 GGSFCEKDTEGC 1088
G C ++ + C
Sbjct: 1176 HGVNCSEEIDEC 1187
Score = 75.1 bits (183), Expect = 4e-13
Identities = 37/93 (39%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 1010 DPCENNP-CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGT--CIDEVN 1066
DP +P C + GTC Y C+C GF GE CE D+++CL +PC+ GT C+ VN
Sbjct: 1230 DPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVN 1289
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
F C C + G CE GC K G C
Sbjct: 1290 DFHCECRAGHTGRRCESVINGCKGKPCKNGGTC 1322
Score = 73.9 bits (180), Expect = 9e-13
Identities = 32/96 (33%), Positives = 46/96 (47%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E ++ C + C +GGTC + C C GF G C+ D+++C PC +GGTC D
Sbjct: 981 ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYR 1101
+ C C Y G C+ CD K G C++
Sbjct: 1041 GSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQ 1076
Score = 72.4 bits (176), Expect = 3e-12
Identities = 31/82 (37%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 1009 SDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP--CENGGTCIDEVN 1066
+DPC +NPC +GG C Y C C F G C D+++C P C +GGTC +EV
Sbjct: 141 ADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVG 200
Query: 1067 GFVCLCLPSYGGSFCEKDTEGC 1088
+ C+C ++ G CE+ C
Sbjct: 201 SYRCVCRATHTGPNCERPYVPC 222
Score = 70.5 bits (171), Expect = 1e-11
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 2/85 (2%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP--CENGGTCID 1063
E + D C N C +GG C Y C C + G+ C D+D+C P C+NGGTC +
Sbjct: 255 EENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHN 314
Query: 1064 EVNGFVCLCLPSYGGSFCEKDTEGC 1088
G+ C+C+ + G C ++ + C
Sbjct: 315 THGGYNCVCVNGWTGEDCSENIDDC 339
Score = 67.0 bits (162), Expect = 1e-10
Identities = 37/93 (39%), Positives = 43/93 (46%), Gaps = 7/93 (7%)
Query: 1012 CENNP--CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
C P C HGGTC+ Y C C G NCE C SPC+NGGTC G V
Sbjct: 182 CGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTC--RPTGDV 239
Query: 1070 ---CLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
C CLP + G CE++ + C K G C
Sbjct: 240 THECACLPGFTGQNCEENIDDCPGNNCKNGGAC 272
Score = 66.2 bits (160), Expect = 2e-10
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 7/104 (6%)
Query: 986 EVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTM----YGCSCDQGFAGE 1041
E A+G E + G G +PC + PC + GTC+ Y CSC GF+G
Sbjct: 38 EAANGTEACVCGGAF-VGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGP 96
Query: 1042 NCEIDIDD-CLCSPCENGGTC-IDEVNGFVCLCLPSYGGSFCEK 1083
C +D+ CL +PC NGGTC + + + C C P + G C++
Sbjct: 97 LCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ 140
Score = 65.1 bits (157), Expect = 4e-10
Identities = 30/74 (40%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 1010 DPCE--NNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNG 1067
D C+ N C +GGTC+ Y C C G+ GE+C +IDDC + C +G TC D V
Sbjct: 297 DECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVAS 356
Query: 1068 FVCLCLPSYGGSFC 1081
F C C G C
Sbjct: 357 FYCECPHGRTGLLC 370
Score = 64.7 bits (156), Expect = 6e-10
Identities = 32/82 (39%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Query: 1012 CENNPCLHGGT--CNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN--- 1066
C +NPC GT C + C C G G CE I+ C PC+NGGTC N
Sbjct: 1271 CLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTAR 1330
Query: 1067 GFVCLCLPSYGGSFCEKDTEGC 1088
GF+C C + G+ CE D C
Sbjct: 1331 GFICKCPAGFEGATCENDARTC 1352
Score = 63.5 bits (153), Expect = 1e-09
Identities = 32/74 (43%), Positives = 37/74 (50%), Gaps = 3/74 (4%)
Query: 1012 CENNPCLHGGTCN-ANGTMYG--CSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGF 1068
C+ PC +GGTC A+ T G C C GF G CE D C C NGGTCI
Sbjct: 1311 CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSP 1370
Query: 1069 VCLCLPSYGGSFCE 1082
CLCL + G C+
Sbjct: 1371 TCLCLGPFTGPECQ 1384
Score = 62.8 bits (151), Expect = 2e-09
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTC-IDEVNG- 1067
D C + C HG TC+ + C C G G C ++ D C+ +PC G C + VNG
Sbjct: 337 DDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGK 395
Query: 1068 FVCLCLPSYGGSFCEKDTEGCDRG 1091
+C C Y G C +D + C G
Sbjct: 396 AICTCPSGYTGPACSQDVDECSLG 419
Score = 54.3 bits (129), Expect = 8e-07
Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 5/69 (7%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTC--IDE--VNGFVCLC 1072
CL+GG C A C C F G C+ D + CL +PC+N GTC +D V + C C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVDRRGVADYACSC 89
Query: 1073 LPSYGGSFC 1081
+ G C
Sbjct: 90 ALGFSGPLC 98
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 96.3 bits (238), Expect = 2e-19
Identities = 38/95 (40%), Positives = 54/95 (56%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C + PC HG TC Y C C G+AG CE+++D+C +PC +GG+C+D V
Sbjct: 106 ELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGV 165
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
F C+C P YGG+ C+ D + C G C+
Sbjct: 166 GSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCH 200
Score = 90.1 bits (222), Expect = 1e-17
Identities = 39/92 (42%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 1007 VHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN 1066
V D C + PCL+GG C + C C G+AG CE D+D+CL PC +GGTC D V
Sbjct: 319 VEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVA 378
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGH 1098
G++C C ++GG C GC QGH
Sbjct: 379 GYICRCPETWGGRDCSVQLTGC-------QGH 403
Score = 86.3 bits (212), Expect = 2e-16
Identities = 36/84 (42%), Positives = 49/84 (58%), Gaps = 1/84 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C + PCLHGG+C + C C G+ G C++D+D+C PC +GGTC D V
Sbjct: 144 EMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLV 203
Query: 1066 NGFVCLCL-PSYGGSFCEKDTEGC 1088
NGF C C Y G+ CE++ C
Sbjct: 204 NGFRCDCAGTGYEGTHCEREVLEC 227
Score = 83.2 bits (204), Expect = 2e-15
Identities = 33/91 (36%), Positives = 50/91 (54%), Gaps = 1/91 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSC-DQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGF 1068
D C++ PC HGGTC+ + C C G+ G +CE ++ +C +PCE+ +C++ + F
Sbjct: 186 DECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF 245
Query: 1069 VCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
CLC P Y G CE D + C + G C
Sbjct: 246 RCLCWPGYSGELCEVDEDECASSPCQHGGRC 276
Score = 82.0 bits (201), Expect = 3e-15
Identities = 38/104 (36%), Positives = 50/104 (48%), Gaps = 21/104 (20%)
Query: 1006 EVHSDPCENNPCLHGGTC--NANGTMYG-------------------CSCDQGFAGENCE 1044
EV D C ++PC HGG C ++ +YG C C GF G +C
Sbjct: 259 EVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCG 318
Query: 1045 IDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
+++D+C PC NGG C D NGF C C Y G CE+D + C
Sbjct: 319 VEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDEC 362
Score = 75.5 bits (184), Expect = 3e-13
Identities = 43/127 (33%), Positives = 58/127 (45%), Gaps = 12/127 (9%)
Query: 971 LEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHS----DP--CENNPCLHGGTCN 1024
L +LAG+ E A +P PGT A ++ +P C PC HG C
Sbjct: 27 LSLLAGTVPSEP---PSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCV 83
Query: 1025 ANG---TMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFC 1081
G T + C C GF G CE+DID+C PC +G TC + + + C C Y G C
Sbjct: 84 PQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTC 143
Query: 1082 EKDTEGC 1088
E + + C
Sbjct: 144 EMEVDEC 150
Score = 67.0 bits (162), Expect = 1e-10
Identities = 38/135 (28%), Positives = 57/135 (42%), Gaps = 32/135 (23%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN----- 1066
C + PC H +C + C C G++GE CE+D D+C SPC++GG C+ +
Sbjct: 227 CASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYG 286
Query: 1067 ----------------GFVCLCLPSYGGSFCEKDTEGCD-----RGWH------KFQGHC 1099
GF+C C P + G+ C + + C G H FQ HC
Sbjct: 287 GVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHC 346
Query: 1100 YRYFAHRRAWEDAEK 1114
+A ED ++
Sbjct: 347 PDGYAGPTCEEDVDE 361
Score = 65.9 bits (159), Expect = 3e-10
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 4/80 (5%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCI----DEV 1065
D C ++PCLHGGTC+ Y C C + + G +C + + C C TCI V
Sbjct: 360 DECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGV 419
Query: 1066 NGFVCLCLPSYGGSFCEKDT 1085
+ +VC C P G FC ++T
Sbjct: 420 HSYVCHCPPGTHGPFCGQNT 439
Score = 62.4 bits (150), Expect = 3e-09
Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 1007 VHSDPCENN-PCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
V S C N CL G C CSC +G AG+ C++ C +PC NGGTC
Sbjct: 1133 VPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAG 1192
Query: 1066 NGFVCLCLPSYGGSFCE 1082
C+C + G FCE
Sbjct: 1193 GVSECICNARFSGQFCE 1209
Score = 61.2 bits (147), Expect = 6e-09
Identities = 25/70 (35%), Positives = 32/70 (45%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +PCLH G C + C+C G+ G CE +D C +PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 1072 CLPSYGGSFC 1081
C P +GG C
Sbjct: 1120 CPPGFGGPRC 1129
Score = 51.6 bits (122), Expect = 5e-06
Identities = 26/87 (29%), Positives = 33/87 (37%), Gaps = 3/87 (3%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCS---PCENGGTCI 1062
E H DPC + PC G + C C GF G C + + CS C +G C
Sbjct: 1092 EAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCE 1151
Query: 1063 DEVNGFVCLCLPSYGGSFCEKDTEGCD 1089
C CL G C+ T C+
Sbjct: 1152 GGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Score = 50.4 bits (119), Expect = 1e-05
Identities = 25/71 (35%), Positives = 33/71 (46%), Gaps = 1/71 (1%)
Query: 1001 NAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGT 1060
N A V D C +PC +GGTC + C+C F G C + C PC T
Sbjct: 800 NLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPAT 858
Query: 1061 CIDEVNGFVCL 1071
C + +GFVC+
Sbjct: 859 CEEVPDGFVCV 869
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/40 (50%), Positives = 28/40 (70%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEI 1045
+V + PCE NPCL+GGTC A G + C C+ F+G+ CE+
Sbjct: 1171 QVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 37.7 bits (86), Expect = 0.073
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 1050 CLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
C SPC + G C D + F C C P + G CE + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPC 1098
Score = 36.2 bits (82), Expect = 0.21
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 1048 DDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFC 1081
D C PC NGGTC+ N F C C ++ G C
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842
Score = 33.5 bits (75), Expect = 1.4
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDI 1047
+ C PC+HGG+C T + C C + G C +I
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 95.9 bits (237), Expect = 2e-19
Identities = 38/79 (48%), Positives = 52/79 (65%), Gaps = 1/79 (1%)
Query: 1011 PCENNPCLHGGTCNANGTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
PC +PC +GGTC +G + Y C+C GF G+NCE+++DDC C NGGTC+D VN +
Sbjct: 200 PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYN 259
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C P + G FC +D + C
Sbjct: 260 CQCPPEWTGQFCTEDVDEC 278
Score = 94.0 bits (232), Expect = 9e-19
Identities = 30/83 (36%), Positives = 53/83 (63%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV D C+++PC++GG C + C+C GF+G C++D+D+C +PC NG C+D+
Sbjct: 467 EVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQP 526
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+G+ C C + G+ C+++ + C
Sbjct: 527 DGYECRCAEGFEGTLCDRNVDDC 549
Score = 91.3 bits (225), Expect = 6e-18
Identities = 38/77 (49%), Positives = 46/77 (59%), Gaps = 1/77 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C+ NPCL+GG+C + CSC GFAG C D+D+CL +PC GTC D V F C
Sbjct: 853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTCT 911
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C P YGG CE+D C
Sbjct: 912 CPPGYGGFHCEQDLPDC 928
Score = 90.5 bits (223), Expect = 1e-17
Identities = 38/86 (44%), Positives = 49/86 (56%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E DPC PC HGGTC Y C C G+ G+NCE D+D+C PC++GG+CID V
Sbjct: 1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLV 1141
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRG 1091
++C C P G CE + + C G
Sbjct: 1142 ARYLCSCPPGTLGVLCEINEDDCGPG 1167
Score = 87.4 bits (215), Expect = 8e-17
Identities = 41/94 (43%), Positives = 54/94 (57%), Gaps = 3/94 (3%)
Query: 995 LPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP 1054
LPG A +V D C +NPC GTC + + C+C G+ G +CE D+ DC S
Sbjct: 876 LPGFAGPRCARDV--DECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS 932
Query: 1055 CENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
C NGGTC+D VN F CLC P Y G+ C+ + + C
Sbjct: 933 CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966
Score = 85.5 bits (210), Expect = 3e-16
Identities = 36/83 (43%), Positives = 45/83 (54%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E + C + PC + TC + C C GF G CE+DID+C SPC NGG C D V
Sbjct: 429 ETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRV 488
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
NGF C C + GS C+ D + C
Sbjct: 489 NGFSCTCPSGFSGSTCQLDVDEC 511
Score = 84.0 bits (206), Expect = 9e-16
Identities = 33/93 (35%), Positives = 49/93 (52%)
Query: 996 PGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPC 1055
PG A ++V NPC H G C + C C +G+ G CE D+++CL PC
Sbjct: 381 PGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPC 440
Query: 1056 ENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
N TC+D + F C+C+ + G++CE D + C
Sbjct: 441 RNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC 473
Score = 79.3 bits (194), Expect = 2e-14
Identities = 44/104 (42%), Positives = 49/104 (47%), Gaps = 9/104 (8%)
Query: 995 LPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP 1054
LPG N E D C + PC HGG+C Y CSC G G CEI+ DDC P
Sbjct: 1111 LPG--YNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGP 1168
Query: 1055 -------CENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRG 1091
C + GTC+D V GF C C P Y G CE D C G
Sbjct: 1169 PLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSG 1212
Score = 79.0 bits (193), Expect = 3e-14
Identities = 30/72 (41%), Positives = 42/72 (58%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C GG C + + C C +G G +CE ++D CL PC++GGTC + G++C CLP Y
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Query: 1077 GGSFCEKDTEGC 1088
G CE D + C
Sbjct: 1115 NGDNCEDDVDEC 1126
Score = 77.8 bits (190), Expect = 6e-14
Identities = 34/83 (40%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
EV+ D C +NPC G C Y C C GF G C ++I++C SPC GG+C+D
Sbjct: 618 EVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGE 676
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
NGF CLC P C + C
Sbjct: 677 NGFRCLCPPGSLPPLCLPPSHPC 699
Score = 77.4 bits (189), Expect = 8e-14
Identities = 33/83 (39%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E D C + PC HGG C Y C C G G NCE++IDDC +PC G C D +
Sbjct: 580 ESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGI 638
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
N + C+C P + G C + C
Sbjct: 639 NRYDCVCQPGFTGPLCNVEINEC 661
Score = 76.6 bits (187), Expect = 1e-13
Identities = 31/85 (36%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSP--CENGGTCID 1063
EV+ D C + CL+GGTC Y C C + G+ C D+D+C P C NGGTC +
Sbjct: 234 EVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFN 293
Query: 1064 EVNGFVCLCLPSYGGSFCEKDTEGC 1088
+ G C+C+ + G C ++ + C
Sbjct: 294 TLGGHSCVCVNGWTGESCSQNIDDC 318
Score = 75.5 bits (184), Expect = 3e-13
Identities = 34/81 (41%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 1011 PCENNPCLHGGTC-NANGTMYGCSCDQGFAGENCEIDIDDCLC-SPCENGGTCIDEVNGF 1068
PC NPC HGG C +A G + CSC QG+ G C+ D+D+C +PC G C + F
Sbjct: 774 PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSF 833
Query: 1069 VCLCLPSYGGSFCEKDTEGCD 1089
C C Y G C++D CD
Sbjct: 834 SCTCHGGYTGPSCDQDINDCD 854
Score = 75.1 bits (183), Expect = 4e-13
Identities = 30/73 (41%), Positives = 41/73 (56%)
Query: 1016 PCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPS 1075
PC G C + C+C G+ G +C+ DI+DC +PC NGG+C D V F C CLP
Sbjct: 819 PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPG 878
Query: 1076 YGGSFCEKDTEGC 1088
+ G C +D + C
Sbjct: 879 FAGPRCARDVDEC 891
Score = 74.7 bits (182), Expect = 5e-13
Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 1010 DPCENNPCLHGGTCNANGT-MYGCSCDQGFAGENCEIDIDDC-LCSPCENGGTCIDEVNG 1067
DPC ++PC HG C+ + CSC G+ G +C D+D+C + PC +GGTC++
Sbjct: 121 DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180
Query: 1068 FVCLCLPSYGGSFCEKDTEGC 1088
F C C Y G CE C
Sbjct: 181 FRCQCPAGYTGPLCENPAVPC 201
Score = 74.7 bits (182), Expect = 5e-13
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C + PC +G C Y C C +GF G C+ ++DDC PC + G C+D + F
Sbjct: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH-GRCVDGIASFS 567
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
C C P Y G+ CE + C + G C
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKC 597
Score = 72.0 bits (175), Expect = 4e-12
Identities = 44/155 (28%), Positives = 60/155 (38%), Gaps = 14/155 (9%)
Query: 965 GIEDFELEVLAGSPGVESFWEEVASGEEPALPGT------------PMNAGAEEVHSD-- 1010
G+ F L G G + P PGT P G D
Sbjct: 867 GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP 926
Query: 1011 PCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVC 1070
C + C +GGTC + C C G+ G +C+ + D CL PC +GG C GF C
Sbjct: 927 DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986
Query: 1071 LCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAH 1105
CL S+ G C+ + C R + G C + A+
Sbjct: 987 TCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021
Score = 70.5 bits (171), Expect = 1e-11
Identities = 32/94 (34%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 996 PGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPC 1055
PG ++ + D CE+ PC GGTC+++G + C+C G G CE+ + C +PC
Sbjct: 722 PGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPC 780
Query: 1056 ENGGTCIDEVNGF-VCLCLPSYGGSFCEKDTEGC 1088
E+GG C VC C + G C++D + C
Sbjct: 781 EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDEC 814
Score = 69.7 bits (169), Expect = 2e-11
Identities = 28/79 (35%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +PC H G C + C+C G+ G CE +D+C PC +GG C+D V+ ++
Sbjct: 547 DDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C G CE + + C
Sbjct: 606 CRCPSGTTGVNCEVNIDDC 624
Score = 68.9 bits (167), Expect = 3e-11
Identities = 34/87 (39%), Positives = 45/87 (51%), Gaps = 6/87 (6%)
Query: 1010 DPCENNPCLHGGTCNAN---GTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
DPC + PC G C ++ GT + C C +GF G +C + D CL SPC +G C
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGP 138
Query: 1066 NG-FVCLCLPSYGGSFCEKDTEGCDRG 1091
+G F+C C P Y G C D + C G
Sbjct: 139 DGRFLCSCPPGYQGRSCRSDVDECRVG 165
Score = 68.6 bits (166), Expect = 4e-11
Identities = 32/81 (39%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 1010 DPCE-NNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN-G 1067
D C PC HGGTC + C C G+ G CE C SPC NGGTC +
Sbjct: 160 DECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT 219
Query: 1068 FVCLCLPSYGGSFCEKDTEGC 1088
+ C CLP + G CE + + C
Sbjct: 220 YDCACLPGFEGQNCEVNVDDC 240
Score = 67.4 bits (163), Expect = 9e-11
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 1010 DPCENNPCLHGGTCNANGTMYG--CSCDQGFAGENCEIDIDDCL--CSPCENGGTCIDEV 1065
D C +NPC C+ N C+C GF G C+ D+D+C +PCE+ G C++
Sbjct: 353 DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQ 412
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
F+C C Y G CE D C G + Q C
Sbjct: 413 GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATC 446
Score = 63.9 bits (154), Expect = 1e-09
Identities = 30/80 (37%), Positives = 39/80 (48%)
Query: 1005 EEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDE 1064
E+V + N C +GGTC + C C G+ GE+C +IDDC + C +G TC D
Sbjct: 273 EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR 332
Query: 1065 VNGFVCLCLPSYGGSFCEKD 1084
V F C C G C D
Sbjct: 333 VASFYCACPMGKTGLLCHLD 352
Score = 59.3 bits (142), Expect = 2e-08
Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 10/104 (9%)
Query: 1006 EVHSDPCENNP-------CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENG 1058
E++ D C P CLH GTC + C+C G+ G CE DI++C C
Sbjct: 1158 EINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAA 1217
Query: 1059 GT--CI-DEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
T C+ D GF CLC + G C+ C+ + G C
Sbjct: 1218 HTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC 1261
Score = 52.8 bits (125), Expect = 2e-06
Identities = 27/76 (35%), Positives = 30/76 (39%), Gaps = 5/76 (6%)
Query: 1011 PCENNPCLHGGTCNAN-----GTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
PCE+ PC HGG C + G + C C Q F G CE C C G C
Sbjct: 1249 PCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTP 1308
Query: 1066 NGFVCLCLPSYGGSFC 1081
G C C P G C
Sbjct: 1309 RGPRCACPPGLSGPSC 1324
Score = 50.1 bits (118), Expect = 1e-05
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 1/77 (1%)
Query: 1007 VHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN 1066
V + C ++PC GG+C + C C G C C PC + G C D
Sbjct: 656 VEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSH-GICYDAPG 714
Query: 1067 GFVCLCLPSYGGSFCEK 1083
GF C+C P + G C +
Sbjct: 715 GFRCVCEPGWSGPRCSQ 731
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/134 (23%), Positives = 48/134 (35%), Gaps = 37/134 (27%)
Query: 991 EEPALPGTPMNAGAEEVHSDPCEN----------------------NPCLHGGTCNANGT 1028
E+ PG P+++G +H+ C + N C G C+A T
Sbjct: 1161 EDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC-RSGACHAAHT 1219
Query: 1029 M---------YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN-----GFVCLCLP 1074
+ C C GF+G C+ + C PC++GG C F C C
Sbjct: 1220 RDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQ 1279
Query: 1075 SYGGSFCEKDTEGC 1088
+ G CE+ C
Sbjct: 1280 PFWGPRCERVARSC 1293
Score = 40.0 bits (92), Expect = 0.015
Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 7/53 (13%)
Query: 994 ALPGTPMNAGAEEVHSDPCENNPCLHGGTCNAN--GTMYGCSCDQGFAGENCE 1044
+ PG+P A + C PCLHGG+C + C+C QG+ G CE
Sbjct: 1326 SFPGSPPGAS-----NASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
>gi|4505245 mannose receptor C type 1 precursor [Homo sapiens]
Length = 1456
Score = 95.9 bits (237), Expect = 2e-19
Identities = 73/231 (31%), Positives = 104/231 (45%), Gaps = 40/231 (17%)
Query: 1031 GCSCDQGFAGENCEIDIDDC---LCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEG 1087
G SC G+N + + +C L C+ G T + N FV +PS E D
Sbjct: 313 GKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTL---NSFV---IPS------ESDVPT 360
Query: 1088 -CDRGWHKFQGHCYRYFA-HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINS-FGHE--- 1141
C W + GHCY+ ++ DA CR+ G LTS+H+ EE FI S G+E
Sbjct: 361 HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND 420
Query: 1142 NTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCN 1201
WIGLND ++ F+W+D T + F W +P + EDCVVM + G W D C
Sbjct: 421 ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKG-KDGYWADRGCE 479
Query: 1202 YNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHH 1252
+ L Y+CK + GP ++ K C +G+ +HH
Sbjct: 480 WPLGYICKMKSRSQGP-------EIVEVEKG-----------CRKGWKKHH 512
Score = 90.9 bits (224), Expect = 7e-18
Identities = 47/166 (28%), Positives = 81/166 (48%), Gaps = 16/166 (9%)
Query: 1087 GCDRGWHKFQGHCYRYFA----HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHEN 1142
GC GW+ + C++ F R+ W++A K C G+L S+ + +E +F+ ++
Sbjct: 944 GCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDS 1003
Query: 1143 T---WIGLNDRIVERDFQWTDNTGLQFENWRENQP----DNFFAGGEDCVVMV---AHES 1192
T W GLND E F WTD G+ + NW + P + DCVV++ ++E+
Sbjct: 1004 TFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEA 1063
Query: 1193 GRWNDVPCNYNLPYVC--KKGTVLCGPPPAVENASLIGARKAKYNV 1236
G+W D C+ Y+C + L PP ++ + K+ Y++
Sbjct: 1064 GKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSL 1109
Score = 70.9 bits (172), Expect = 8e-12
Identities = 43/133 (32%), Positives = 62/133 (46%), Gaps = 11/133 (8%)
Query: 1092 WHKFQGHCYRY-FAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFIN-----SFGHENTWI 1145
W F GHCY ++ R W A +C R L S+ S E SF++ N WI
Sbjct: 1238 WIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWI 1297
Query: 1146 GLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLP 1205
GL R VE + W +N+ + F NW P DCV + A SG W+++ C+
Sbjct: 1298 GL-FRNVEGTWLWINNSPVSFVNWNTGDPS---GERNDCVALHA-SSGFWSNIHCSSYKG 1352
Query: 1206 YVCKKGTVLCGPP 1218
Y+CK+ ++ P
Sbjct: 1353 YICKRPKIIDAKP 1365
Score = 68.6 bits (166), Expect = 4e-11
Identities = 36/138 (26%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Query: 1080 FCEKDTEGCDRGWHKFQGHCYRYFAHRRA---WEDAEKDCRRRSGHLTSVHSPEEHSFIN 1136
+C EG + W+K Y + ++ W A K C++++ L S+ E +++
Sbjct: 208 YCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLT 267
Query: 1137 SFGHENT---WIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESG 1193
T WIGLN +QW+D + ++ NW P G+ CV + ++
Sbjct: 268 GLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPS--AEPGKSCVSLNPGKNA 325
Query: 1194 RWNDVPCNYNLPYVCKKG 1211
+W ++ C L Y+CKKG
Sbjct: 326 KWENLECVQKLGYICKKG 343
Score = 68.2 bits (165), Expect = 5e-11
Identities = 38/148 (25%), Positives = 64/148 (43%), Gaps = 9/148 (6%)
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSV 1126
G++C G + +GC +GW K +CY + +A + C + +LT++
Sbjct: 483 GYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTI 542
Query: 1127 HSPEEHSFINSF----GHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGE 1182
E +F+ SF + W GL+D + FQWT ++F +W + P
Sbjct: 543 EDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGR----KP 598
Query: 1183 DCVVM-VAHESGRWNDVPCNYNLPYVCK 1209
CV M G W+ + C+ +VCK
Sbjct: 599 GCVAMRTGIAGGLWDVLKCDEKAKFVCK 626
Score = 66.2 bits (160), Expect = 2e-10
Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 8/125 (6%)
Query: 1091 GWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENT-----WI 1145
GW ++ + Y + + ++A C+R G L S+ S E F+ + + N +I
Sbjct: 803 GWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFI 862
Query: 1146 GLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLP 1205
GL + ++ F W D + + + +W +P NF E+CV M ++ SG WND+ C Y
Sbjct: 863 GLLISL-DKKFAWMDGSKVDYVSWATGEP-NFANEDENCVTMYSN-SGFWNDINCGYPNA 919
Query: 1206 YVCKK 1210
++C++
Sbjct: 920 FICQR 924
Score = 59.7 bits (143), Expect = 2e-08
Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1099 CYRYFA----HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFI------NSFGHENTWIGLN 1148
C++ +A ++ W ++ CR G L S+++ EE I + H+ W+GL
Sbjct: 659 CFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLT 718
Query: 1149 DRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVC 1208
F W+D + + +ENW +P+N + E C + + WND+ C + ++C
Sbjct: 719 YGSPSEGFTWSDGSPVSYENWAYGEPNN-YQNVEYCGELKGDPTMSWNDINCEHLNNWIC 777
Query: 1209 K 1209
+
Sbjct: 778 Q 778
Score = 58.9 bits (141), Expect = 3e-08
Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 13/141 (9%)
Query: 1091 GWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFI---NSFGHENTWIGL 1147
G+ K+ Y + W +AE C+ + + S+ P ++F +E WI L
Sbjct: 1098 GFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIAL 1157
Query: 1148 NDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYV 1207
N + + + WTD +++ NW ++P A CV + G W CN + ++
Sbjct: 1158 NSNLTDNQYTWTDKWRVRYTNWAADEPKLKSA----CVYL--DLDGYWKTAHCNESFYFL 1211
Query: 1208 CKKGTVLCGPPPAVENASLIG 1228
CK+ + PA E L G
Sbjct: 1212 CKRSDEI----PATEPPQLPG 1228
>gi|18641360 collectin sub-family member 12 [Homo sapiens]
Length = 742
Score = 95.1 bits (235), Expect = 4e-19
Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 7/132 (5%)
Query: 1084 DTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINS--FGHE 1141
+ GC W F CY + + +EDA+ C +S HL +++ EE +I G E
Sbjct: 603 EDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRE 662
Query: 1142 NTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAG---GEDCVVMVAHESGRWNDV 1198
+ WIGL D E +++W D T ++NW+ QPDN+ G GEDC ++ +G+WND
Sbjct: 663 SHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLI--YAGQWNDF 720
Query: 1199 PCNYNLPYVCKK 1210
C ++C+K
Sbjct: 721 QCEDVNNFICEK 732
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 94.0 bits (232), Expect = 9e-19
Identities = 37/80 (46%), Positives = 49/80 (61%), Gaps = 3/80 (3%)
Query: 1012 CENNPCLHGGTCN---ANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGF 1068
C +NPC HGGTC+ + C C GF GENCE+++DDC + CEN TC+D +N +
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
Query: 1069 VCLCLPSYGGSFCEKDTEGC 1088
CLC P Y G CE+ + C
Sbjct: 1021 TCLCPPEYTGELCEEKLDFC 1040
Score = 82.4 bits (202), Expect = 3e-15
Identities = 33/84 (39%), Positives = 53/84 (63%), Gaps = 4/84 (4%)
Query: 1010 DPCENNPCLHGGTCNANGT-MYGCSCDQGFAGENCEIDIDDCLCSPCENGGTC---IDEV 1065
+PC +NPC + GTCN++ Y C+C GF G++C++ I C+ +PC++GGTC E
Sbjct: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCD 1089
+GF C+C + G CE + + C+
Sbjct: 980 DGFWCICADGFEGENCEVNVDDCE 1003
Score = 81.3 bits (199), Expect = 6e-15
Identities = 31/68 (45%), Positives = 39/68 (57%)
Query: 1015 NPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLP 1074
NPC H C + C C G+ GE+C+ID DDC + C+NG C D VNG+ C+C
Sbjct: 1045 NPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPE 1104
Query: 1075 SYGGSFCE 1082
Y G FCE
Sbjct: 1105 GYSGLFCE 1112
Score = 49.7 bits (117), Expect = 2e-05
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 5/80 (6%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDD-CLCSPCENGGTCIDEVNGF 1068
+PC C HG ++ + C C +G+ G C+ +D CL + C + GTC+ +N F
Sbjct: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCL-PINAF 1391
Query: 1069 --VCLCLPSYGGSFCEKDTE 1086
C CL +GG C+++ +
Sbjct: 1392 SYSCKCLEGHGGVLCDEEED 1411
Score = 49.7 bits (117), Expect = 2e-05
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 1009 SDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDID---DCLCSPCENGGTCIDEV 1065
+DPC N C+HG N Y C C +G G C+ + D C C++G + +
Sbjct: 1372 NDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL 1431
Query: 1066 NGFVCLCLPSYGGSFCEKD 1084
C C Y G C+++
Sbjct: 1432 GQPYCECSSGYTGDSCDRE 1450
Score = 38.5 bits (88), Expect = 0.043
Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 1/66 (1%)
Query: 1036 QGFAGENCEIDIDDCLCSPCENGGTC-IDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHK 1094
QG N + CL +PC+N GTC D V+ + C C + G C+ C K
Sbjct: 908 QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCK 967
Query: 1095 FQGHCY 1100
G C+
Sbjct: 968 HGGTCH 973
Score = 31.2 bits (69), Expect = 6.9
Identities = 15/44 (34%), Positives = 23/44 (52%), Gaps = 2/44 (4%)
Query: 1005 EEVHSDPCENNPCLHGGTCNANGTMYG-CSCDQGFAGENCEIDI 1047
EE +PC+ C HG C +G C C G+ G++C+ +I
Sbjct: 1409 EEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSCDREI 1451
>gi|20149533 Fc fragment of IgE, low affinity II, receptor for (CD23A)
[Homo sapiens]
Length = 321
Score = 93.6 bits (231), Expect = 1e-18
Identities = 50/143 (34%), Positives = 72/143 (50%), Gaps = 6/143 (4%)
Query: 1088 CDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSF-GHENTWIG 1146
C W FQ CY + + W A C G L S+HSPEE F+ H +WIG
Sbjct: 163 CPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIG 222
Query: 1147 LNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNL-P 1205
L + ++ +F W D + + + NW +P + + GEDCV+M SGRWND C+ L
Sbjct: 223 LRNLDLKGEFIWVDGSHVDYSNWAPGEPTS-RSQGEDCVMM--RGSGRWNDAFCDRKLGA 279
Query: 1206 YVCKKGTVLCGPPPAVENASLIG 1228
+VC + C PP + +A +G
Sbjct: 280 WVCDR-LATCTPPASEGSAESMG 301
>gi|53832016 C-type lectin, superfamily member 14 isoform 2 [Homo
sapiens]
Length = 292
Score = 92.8 bits (229), Expect = 2e-18
Identities = 51/139 (36%), Positives = 73/139 (52%), Gaps = 13/139 (9%)
Query: 1082 EKDTEG--CDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSF- 1138
E TEG C W + Q CY + +W +AEK C+ ++ HL ++S EE +F+ +
Sbjct: 149 EASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYL 208
Query: 1139 GHENTWIGLNDRIVERDFQWTDNT--GLQFENWRENQPDNF----FAGGEDCVVMVAHES 1192
G TW+GL+D E ++W D T F+NW+ QPD++ GGEDC H
Sbjct: 209 GSAYTWMGLSD--PEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHF--HPD 264
Query: 1193 GRWNDVPCNYNLPYVCKKG 1211
GRWND C +VC+ G
Sbjct: 265 GRWNDDVCQRPYHWVCEAG 283
>gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens]
Length = 1456
Score = 92.4 bits (228), Expect = 3e-18
Identities = 71/231 (30%), Positives = 102/231 (44%), Gaps = 40/231 (17%)
Query: 1031 GCSCDQGFAGENCEIDIDDC---LCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEG 1087
G SC G+N + + +C L C+ G T + N FV +PS E D
Sbjct: 313 GKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTL---NSFV---IPS------ESDVPT 360
Query: 1088 -CDRGWHKFQGHCYRYFA-HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINS-FGHE--- 1141
C W + GHCY+ ++ DA CR+ L S+H+ EE FI S G+E
Sbjct: 361 HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGSDLASIHTIEEFDFIISQLGYEPND 420
Query: 1142 NTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCN 1201
WIGLND ++ F+W+D T + F W +P + EDCVVM + G W D C
Sbjct: 421 ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKG-KDGYWADRGCE 479
Query: 1202 YNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHH 1252
+ L Y+CK + GP ++ K C +G+ +HH
Sbjct: 480 WPLGYICKMKSRSQGP-------EIVEVEKG-----------CRKGWKKHH 512
Score = 90.9 bits (224), Expect = 7e-18
Identities = 47/166 (28%), Positives = 81/166 (48%), Gaps = 16/166 (9%)
Query: 1087 GCDRGWHKFQGHCYRYFA----HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHEN 1142
GC GW+ + C++ F R+ W++A K C G+L S+ + +E +F+ ++
Sbjct: 944 GCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDS 1003
Query: 1143 T---WIGLNDRIVERDFQWTDNTGLQFENWRENQP----DNFFAGGEDCVVMV---AHES 1192
T W GLND E F WTD G+ + NW + P + DCVV++ ++E+
Sbjct: 1004 TFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEA 1063
Query: 1193 GRWNDVPCNYNLPYVC--KKGTVLCGPPPAVENASLIGARKAKYNV 1236
G+W D C+ Y+C + L PP ++ + K+ Y++
Sbjct: 1064 GKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSL 1109
Score = 70.9 bits (172), Expect = 8e-12
Identities = 43/133 (32%), Positives = 62/133 (46%), Gaps = 11/133 (8%)
Query: 1092 WHKFQGHCYRY-FAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFIN-----SFGHENTWI 1145
W F GHCY ++ R W A +C R L S+ S E SF++ N WI
Sbjct: 1238 WIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWI 1297
Query: 1146 GLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLP 1205
GL R VE + W +N+ + F NW P DCV + A SG W+++ C+
Sbjct: 1298 GL-FRNVEGTWLWINNSPVSFVNWNTGDPS---GERNDCVALHA-SSGFWSNIHCSSYKG 1352
Query: 1206 YVCKKGTVLCGPP 1218
Y+CK+ ++ P
Sbjct: 1353 YICKRPKIIDAKP 1365
Score = 68.6 bits (166), Expect = 4e-11
Identities = 36/138 (26%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Query: 1080 FCEKDTEGCDRGWHKFQGHCYRYFAHRRA---WEDAEKDCRRRSGHLTSVHSPEEHSFIN 1136
+C EG + W+K Y + ++ W A K C++++ L S+ E +++
Sbjct: 208 YCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLT 267
Query: 1137 SFGHENT---WIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESG 1193
T WIGLN +QW+D + ++ NW P G+ CV + ++
Sbjct: 268 GLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPS--AEPGKSCVSLNPGKNA 325
Query: 1194 RWNDVPCNYNLPYVCKKG 1211
+W ++ C L Y+CKKG
Sbjct: 326 KWENLECVQKLGYICKKG 343
Score = 68.2 bits (165), Expect = 5e-11
Identities = 38/148 (25%), Positives = 64/148 (43%), Gaps = 9/148 (6%)
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSV 1126
G++C G + +GC +GW K +CY + +A + C + +LT++
Sbjct: 483 GYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTI 542
Query: 1127 HSPEEHSFINSF----GHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGE 1182
E +F+ SF + W GL+D + FQWT ++F +W + P
Sbjct: 543 EDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGR----KP 598
Query: 1183 DCVVM-VAHESGRWNDVPCNYNLPYVCK 1209
CV M G W+ + C+ +VCK
Sbjct: 599 GCVAMRTGIAGGLWDVLKCDEKAKFVCK 626
Score = 66.2 bits (160), Expect = 2e-10
Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 8/125 (6%)
Query: 1091 GWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENT-----WI 1145
GW ++ + Y + + ++A C+R G L S+ S E F+ + + N +I
Sbjct: 803 GWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFI 862
Query: 1146 GLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLP 1205
GL + ++ F W D + + + +W +P NF E+CV M ++ SG WND+ C Y
Sbjct: 863 GLLISL-DKKFAWMDGSKVDYVSWATGEP-NFANEDENCVTMYSN-SGFWNDINCGYPNA 919
Query: 1206 YVCKK 1210
++C++
Sbjct: 920 FICQR 924
Score = 59.7 bits (143), Expect = 2e-08
Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1099 CYRYFA----HRRAWEDAEKDCRRRSGHLTSVHSPEEHSFI------NSFGHENTWIGLN 1148
C++ +A ++ W ++ CR G L S+++ EE I + H+ W+GL
Sbjct: 659 CFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLT 718
Query: 1149 DRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVC 1208
F W+D + + +ENW +P+N + E C + + WND+ C + ++C
Sbjct: 719 YGSPSEGFTWSDGSPVSYENWAYGEPNN-YQNVEYCGELKGDPTMSWNDINCEHLNNWIC 777
Query: 1209 K 1209
+
Sbjct: 778 Q 778
Score = 58.9 bits (141), Expect = 3e-08
Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 13/141 (9%)
Query: 1091 GWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFI---NSFGHENTWIGL 1147
G+ K+ Y + W +AE C+ + + S+ P ++F +E WI L
Sbjct: 1098 GFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIAL 1157
Query: 1148 NDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYV 1207
N + + + WTD +++ NW ++P A CV + G W CN + ++
Sbjct: 1158 NSNLTDNQYTWTDKWRVRYTNWAADEPKLKSA----CVYL--DLDGYWKTAHCNESFYFL 1211
Query: 1208 CKKGTVLCGPPPAVENASLIG 1228
CK+ + PA E L G
Sbjct: 1212 CKRSDEI----PATEPPQLPG 1228
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 92.0 bits (227), Expect = 3e-18
Identities = 36/80 (45%), Positives = 51/80 (63%), Gaps = 3/80 (3%)
Query: 1012 CENNPCLHGGTCNANGTM---YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGF 1068
C NPC HGGTC+ + + + CSC GF G+ CEI+ DDC + CEN TC+D +N +
Sbjct: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNY 1018
Query: 1069 VCLCLPSYGGSFCEKDTEGC 1088
VC+C P+Y G C++ + C
Sbjct: 1019 VCICPPNYTGELCDEVIDHC 1038
Score = 70.9 bits (172), Expect = 8e-12
Identities = 27/70 (38%), Positives = 37/70 (52%)
Query: 1013 ENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLC 1072
E N C H C + C C G++G+ CE D DDC+ C +G C+D +NG+ C C
Sbjct: 1041 ELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTC 1100
Query: 1073 LPSYGGSFCE 1082
+ G FCE
Sbjct: 1101 PQGFSGPFCE 1110
Score = 70.1 bits (170), Expect = 1e-11
Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 2/85 (2%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCL--CSPCENGGTCID 1063
E++ D CE+N C + TC Y C C + GE C+ ID C+ + C++ CI
Sbjct: 994 EINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIP 1053
Query: 1064 EVNGFVCLCLPSYGGSFCEKDTEGC 1088
GF C C+P Y G CE D + C
Sbjct: 1054 LDKGFSCECVPGYSGKLCETDNDDC 1078
Score = 66.2 bits (160), Expect = 2e-10
Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 4/82 (4%)
Query: 1012 CENNPCLHGGTCNANGT-MYGCSCDQGFAGENCEIDIDDCLCSPCENGGTC---IDEVNG 1067
C ++PC + GTC + +Y C+C + G++C + I+ C+ +PC++GGTC +G
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
Query: 1068 FVCLCLPSYGGSFCEKDTEGCD 1089
F C C + G CE + + C+
Sbjct: 980 FSCSCPLGFEGQRCEINPDDCE 1001
Score = 57.8 bits (138), Expect = 7e-08
Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 4/78 (5%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDD---CLCSPCENGGTCIDEVN 1066
DPC + C H G C A GT Y C C +G+ G+ C+ D C C +G I +
Sbjct: 1370 DPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQG 1428
Query: 1067 GFVCLCLPSYGGSFCEKD 1084
CLC P + G C+++
Sbjct: 1429 EPYCLCQPGFSGEHCQQE 1446
Score = 57.0 bits (136), Expect = 1e-07
Identities = 29/85 (34%), Positives = 36/85 (42%), Gaps = 7/85 (8%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCE-------IDIDDCLCSPCENG 1058
E +D C + C HG C Y C+C QGF+G CE + C C+NG
Sbjct: 1072 ETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNG 1131
Query: 1059 GTCIDEVNGFVCLCLPSYGGSFCEK 1083
CI C C P + G CEK
Sbjct: 1132 AQCIVVQQEPTCRCPPGFAGPRCEK 1156
Score = 42.4 bits (98), Expect = 0.003
Identities = 20/74 (27%), Positives = 31/74 (41%), Gaps = 2/74 (2%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDI-DDCLCSPCENGGTCIDEVNGFVCLCLPS 1075
C HG + C C G+ G C+ + D CL C +G C+ ++C C
Sbjct: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYMCKCAEG 1396
Query: 1076 YGGSFCEKDTEGCD 1089
YGG C+ + +
Sbjct: 1397 YGGDLCDNKNDSAN 1410
Score = 40.4 bits (93), Expect = 0.011
Identities = 21/58 (36%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Query: 1050 CLCSPCENGGTCI-DEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHR 1106
CL SPC+N GTC D V + C C SY G C C + + G C+ +H+
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
Score = 33.5 bits (75), Expect = 1.4
Identities = 18/44 (40%), Positives = 22/44 (50%)
Query: 285 AALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGP 328
A L S+ LHLA + + C WLAD PI+T RC P
Sbjct: 424 APLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSP 467
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 91.3 bits (225), Expect = 6e-18
Identities = 36/88 (40%), Positives = 55/88 (62%), Gaps = 1/88 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +NPC +GG+C+ + + C C G++G C +DID+C +PC GGTC+D+V+GF C+
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
Query: 1072 CLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
C + G+ C+ D C RG + G C
Sbjct: 411 CPEQWVGATCQLDVNDC-RGQCQHGGTC 437
Score = 83.2 bits (204), Expect = 2e-15
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query: 1008 HSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNG 1067
+++ C PC +GG C + C C GFAG +C I+ID+C SPC G TC+DE+NG
Sbjct: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 810
Query: 1068 FVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSG 1121
+ C C P G C++ W + F H +W + CR G
Sbjct: 811 YRCSCPPGRAGPRCQEVIGFGRSCWSRGTP-----FPHGSSWVEDCNSCRCLDG 859
Score = 82.0 bits (201), Expect = 3e-15
Identities = 34/84 (40%), Positives = 45/84 (53%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C HGGTC Y C C +GF G +CE++ D+C SPC +GG C D +GF C C +
Sbjct: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 490
Query: 1077 GGSFCEKDTEGCDRGWHKFQGHCY 1100
G CE D + C+ + CY
Sbjct: 491 SGPLCEVDVDLCEPSPCRNGARCY 514
Score = 80.9 bits (198), Expect = 8e-15
Identities = 35/82 (42%), Positives = 43/82 (52%)
Query: 1019 HGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGG 1078
HG + G + C CD GF G C +IDDCL PC NGGTCIDEV+ F C C + G
Sbjct: 571 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEG 630
Query: 1079 SFCEKDTEGCDRGWHKFQGHCY 1100
C+ + C +G CY
Sbjct: 631 ELCDTNPNDCLPDPCHSRGRCY 652
Score = 80.9 bits (198), Expect = 8e-15
Identities = 32/77 (41%), Positives = 43/77 (55%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C NPC++GGTC +G + C C G+ G C + +DC PC NGG C+D VN F C
Sbjct: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C P + G C + + C
Sbjct: 777 CAPGFAGPDCRINIDEC 793
Score = 80.1 bits (196), Expect = 1e-14
Identities = 32/79 (40%), Positives = 47/79 (59%), Gaps = 1/79 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +NPC GGTC + C C + + G C++D++DC C++GGTC D VNG+
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQ 445
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C+C +GG CE + + C
Sbjct: 446 CVCPRGFGGRHCELERDEC 464
Score = 78.6 bits (192), Expect = 4e-14
Identities = 33/86 (38%), Positives = 43/86 (50%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C ++PC GG C + C C QGF+G CE+D+D C SPC NG C +
Sbjct: 458 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE 517
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRG 1091
+ C C +GG C E C G
Sbjct: 518 GDYYCACPDDFGGKNCSVPREPCPGG 543
Score = 73.9 bits (180), Expect = 9e-13
Identities = 34/91 (37%), Positives = 42/91 (46%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C PC +GGTC + C C G+ GE C+ + +DCL PC + G C D VN F
Sbjct: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
C C + G C CD G CY
Sbjct: 660 CACDDGWKGKTCHSREFQCDAYTCSNGGTCY 690
Score = 68.6 bits (166), Expect = 4e-11
Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDD-CLCSPCENGGTCIDEVNGFVC 1070
C+ C +GGTC +G + C+C G+ G C + + CL +PC NGGTC+ F C
Sbjct: 678 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 737
Query: 1071 LCLPSYGGSFCEKDTEGCD 1089
+C + G C +T C+
Sbjct: 738 ICRDGWEGRTCTHNTNDCN 756
Score = 58.5 bits (140), Expect = 4e-08
Identities = 26/76 (34%), Positives = 36/76 (47%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
+ + + C +PC G C + C+CD G+ G+ C C C NGGTC D
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 693
Query: 1066 NGFVCLCLPSYGGSFC 1081
+ F C C P + GS C
Sbjct: 694 DTFRCACPPGWKGSTC 709
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/94 (32%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
Query: 1010 DPCENNP-CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCS-PCENGGTCID-EVN 1066
D C P C+HG + C+C+ + G C+ D++ C PC NGGTCI+ E +
Sbjct: 274 DECVPYPGCVHGSCVEP----WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
+ C C Y G CEK C G C+
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363
Score = 43.1 bits (100), Expect = 0.002
Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 1007 VHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDID---DCLC--SPCENGGTC 1061
++ D C+++PC +G TC Y CSC G AG C+ I C +P +G +
Sbjct: 788 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSW 847
Query: 1062 IDEVNGFVCL 1071
+++ N CL
Sbjct: 848 VEDCNSCRCL 857
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 11/71 (15%)
Query: 1018 LHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYG 1077
LHGG C G C C G+ G C D+C+ P G+C++ + C C ++G
Sbjct: 252 LHGG-CTVPGE---CRCSYGWQGRFC----DECVPYPGCVHGSCVEP---WQCNCETNWG 300
Query: 1078 GSFCEKDTEGC 1088
G C+KD C
Sbjct: 301 GLLCDKDLNYC 311
>gi|33667103 C-type lectin, superfamily member 14 isoform 1 [Homo
sapiens]
Length = 316
Score = 91.3 bits (225), Expect = 6e-18
Identities = 50/136 (36%), Positives = 72/136 (52%), Gaps = 13/136 (9%)
Query: 1085 TEG--CDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSF-GHE 1141
TEG C W + Q CY + +W +AEK C+ ++ HL ++S EE +F+ + G
Sbjct: 176 TEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSA 235
Query: 1142 NTWIGLNDRIVERDFQWTDNT--GLQFENWRENQPDNF----FAGGEDCVVMVAHESGRW 1195
TW+GL+D E ++W D T F+NW+ QPD++ GGEDC H GRW
Sbjct: 236 YTWMGLSD--PEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHF--HPDGRW 291
Query: 1196 NDVPCNYNLPYVCKKG 1211
ND C +VC+ G
Sbjct: 292 NDDVCQRPYHWVCEAG 307
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 90.9 bits (224), Expect = 7e-18
Identities = 35/78 (44%), Positives = 49/78 (62%), Gaps = 1/78 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E++ D C +NPC+HG C+ Y C+C+ G+ G NCE+DID+C C NG TCI
Sbjct: 1175 ELNIDECFSNPCIHGN-CSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHT 1233
Query: 1066 NGFVCLCLPSYGGSFCEK 1083
NG+ CLC ++ G FC +
Sbjct: 1234 NGYSCLCFGNFTGKFCRQ 1251
Score = 87.8 bits (216), Expect = 6e-17
Identities = 56/196 (28%), Positives = 81/196 (41%), Gaps = 34/196 (17%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCD-QGFAGENCEIDIDDCLCSPCENGGTCIDE 1064
E+++D C + PCLHGG C Y C+C GF G +CE + C PC N TC D
Sbjct: 260 ELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDS 319
Query: 1065 VNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLT 1124
V+ + C C P Y G+ CE D C+ + G C E ++ G +T
Sbjct: 320 VDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGEC------------VELSSEKQYGRIT 367
Query: 1125 SVHSPEEHSFINSFGH----ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNF--- 1177
+ P S+ + G+ + + G++ E D + Q EN P N+
Sbjct: 368 GL--PSSFSYHEASGYVCICQPGFTGIH---CEEDVNECSSNPCQNGGTCENLPGNYTCH 422
Query: 1178 ---------FAGGEDC 1184
F GG DC
Sbjct: 423 CPFDNLSRTFYGGRDC 438
Score = 87.0 bits (214), Expect = 1e-16
Identities = 33/77 (42%), Positives = 45/77 (58%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C N C HGG C+ + C C G+AG CEID D+C SPC+NG C D ++G+ C
Sbjct: 114 CGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCF 173
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C+P Y G C+ + + C
Sbjct: 174 CVPGYQGRHCDLEVDEC 190
Score = 86.7 bits (213), Expect = 1e-16
Identities = 35/77 (45%), Positives = 48/77 (62%), Gaps = 1/77 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +NPCLHGG C + Y CSC G++G++CE++ID+C +PC + G C D V + C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAAYHCT 1201
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C P Y G CE D + C
Sbjct: 1202 CEPGYTGVNCEVDIDNC 1218
Score = 83.2 bits (204), Expect = 2e-15
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 972 EVLAGSPGVESFWEEVASGEEPALPGTPMNAGAE----EVHSDPCENNPCLHGGTCNANG 1027
E GS G S ++P P AG E+ D C ++PC +G C
Sbjct: 108 ETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGI 167
Query: 1028 TMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEG 1087
Y C C G+ G +C++++D+C PC+N TC++E+ + C+C +Y G CE + +
Sbjct: 168 DGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDE 227
Query: 1088 C 1088
C
Sbjct: 228 C 228
Score = 80.1 bits (196), Expect = 1e-14
Identities = 31/83 (37%), Positives = 46/83 (55%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
++ D C ++PC + TC Y C C ++G NCE++ID+C PC NG TC D +
Sbjct: 184 DLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDAL 243
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
+ C C P + G CE +T+ C
Sbjct: 244 GAYFCDCAPGFLGDHCELNTDEC 266
Score = 75.9 bits (185), Expect = 2e-13
Identities = 32/78 (41%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C + PCL+G TC Y C C GF G++CE++ D+C PC +GG C+D
Sbjct: 222 ELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGE 281
Query: 1066 NGFVCLCLPS-YGGSFCE 1082
N + C C S + G+ CE
Sbjct: 282 NRYSCNCTGSGFTGTHCE 299
Score = 75.9 bits (185), Expect = 2e-13
Identities = 34/71 (47%), Positives = 39/71 (54%)
Query: 1014 NNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCL 1073
N C +GG C T C C GF GE CE DID+C PC NGG C D +N F CLC
Sbjct: 1265 NLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCD 1324
Query: 1074 PSYGGSFCEKD 1084
++ G CE D
Sbjct: 1325 VAFAGERCEVD 1335
Score = 66.6 bits (161), Expect = 1e-10
Identities = 32/81 (39%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 1010 DPCENNPCLHGGTC-NANGTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNG 1067
DPC +NPC TC N G + C C G++G CE I C + C++GG C +
Sbjct: 72 DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIY 131
Query: 1068 FVCLCLPSYGGSFCEKDTEGC 1088
VC+C Y G FCE D + C
Sbjct: 132 PVCICPAGYAGRFCEIDHDEC 152
Score = 58.9 bits (141), Expect = 3e-08
Identities = 31/81 (38%), Positives = 37/81 (45%), Gaps = 10/81 (12%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQG------FAGENCEIDIDDCLCSPCENGGTCI--- 1062
C +NPC +GGTC Y C C + G +C + C C N GTCI
Sbjct: 401 CSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHF 460
Query: 1063 -DEVNGFVCLCLPSYGGSFCE 1082
D +GF CLC Y GS CE
Sbjct: 461 QDGQHGFSCLCPSGYTGSLCE 481
Score = 55.1 bits (131), Expect = 4e-07
Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 4/94 (4%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQ--GFAGENCEIDIDDCLCSPCENGGTCIDEVN--G 1067
C +N C + TC CSC ++C+ D C +PC+ TC++
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93
Query: 1068 FVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYR 1101
F+C C P Y G+ CE C + + G C++
Sbjct: 94 FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQ 127
Score = 54.7 bits (130), Expect = 6e-07
Identities = 23/67 (34%), Positives = 37/67 (55%), Gaps = 1/67 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C++NPC +GG C++ + CSC +G+ CE ++ C SPC +G C + GF C+
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 1072 CLPSYGG 1078
+ G
Sbjct: 950 ANAVFNG 956
Score = 50.1 bits (118), Expect = 1e-05
Identities = 20/44 (45%), Positives = 27/44 (61%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCS 1053
D C ++PC++GG C + C CD FAGE CE+D+ D L S
Sbjct: 1299 DECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDLIS 1342
Score = 38.1 bits (87), Expect = 0.056
Identities = 17/47 (36%), Positives = 22/47 (46%)
Query: 997 GTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENC 1043
G+ +N A V D CE+ PC G C Y C C + + G NC
Sbjct: 661 GSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 37.4 bits (85), Expect = 0.096
Identities = 18/48 (37%), Positives = 22/48 (45%), Gaps = 6/48 (12%)
Query: 1036 QGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEK 1083
QG AG+N C +PC NGG C + F C C G CE+
Sbjct: 883 QGCAGDN------SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE 924
Score = 35.8 bits (81), Expect = 0.28
Identities = 13/44 (29%), Positives = 23/44 (52%)
Query: 1045 IDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGC 1088
+ ++ C +PC +GG C D + + C C + G CE + + C
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDEC 1181
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 89.7 bits (221), Expect = 2e-17
Identities = 65/226 (28%), Positives = 85/226 (37%), Gaps = 18/226 (7%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
CE+NPC +GGTC Y C C G+ G CE +I+DC +PC NGGTC D VN F C
Sbjct: 633 CESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCD 692
Query: 1072 CLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRR-----AWEDAEKDCRRRSGHL--- 1123
C + G C CD G CY + WE + R S L
Sbjct: 693 CKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP 752
Query: 1124 -----TSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFF 1178
T V + E + + G E N + T + +NW + F
Sbjct: 753 CHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGF 812
Query: 1179 AGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENA 1224
A G DC + + PC + V + C PP A
Sbjct: 813 A-GPDCRINI----NECQSSPCAFGATCVDEINGYRCVCPPGHSGA 853
Score = 87.0 bits (214), Expect = 1e-16
Identities = 32/76 (42%), Positives = 49/76 (64%)
Query: 1008 HSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNG 1067
+++ C +PC + GTC Y C C GFAG +C I+I++C SPC G TC+DE+NG
Sbjct: 782 NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEING 841
Query: 1068 FVCLCLPSYGGSFCEK 1083
+ C+C P + G+ C++
Sbjct: 842 YRCVCPPGHSGAKCQE 857
Score = 85.1 bits (209), Expect = 4e-16
Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 1/94 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
++ ++ CE PC++ +C Y C C G+ G+NC+I+I+DCL C+N +C D V
Sbjct: 410 QLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLV 468
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
NG+ C+C P Y G CE+D + C GHC
Sbjct: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHC 502
Score = 81.6 bits (200), Expect = 4e-15
Identities = 32/84 (38%), Positives = 46/84 (54%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ C ++PC + G+C + C C G+ G C +IDDC + C +GGTC D V
Sbjct: 334 EIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLV 393
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCD 1089
NGF C+C P + G C+ D C+
Sbjct: 394 NGFKCVCPPQWTGKTCQLDANECE 417
Score = 79.7 bits (195), Expect = 2e-14
Identities = 40/111 (36%), Positives = 57/111 (51%), Gaps = 7/111 (6%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C + +C Y C C G+AG++CE DID+C +PC NGG C +E+N F CLC +
Sbjct: 458 CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGF 517
Query: 1077 GGSFCEKDTEGCDRGWHKFQGHCYR----YFAHRRAWEDAE-KDCRRRSGH 1122
G+ C+ D + C+ + CY YF + ED E K+C H
Sbjct: 518 SGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC--KCPEDYEGKNCSHLKDH 566
Score = 78.2 bits (191), Expect = 5e-14
Identities = 35/87 (40%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Query: 1014 NNPCLHGGTCNANGT-MYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLC 1072
+ PCL+GGTC+ G Y CSC +G++G NCEI CL PC N G+C + GF C C
Sbjct: 303 HQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECEC 362
Query: 1073 LPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
P + G C + + C G C
Sbjct: 363 SPGWTGPTCSTNIDDCSPNNCSHGGTC 389
Score = 78.2 bits (191), Expect = 5e-14
Identities = 37/105 (35%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 1014 NNPCLHGGTCNA-NGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLC 1072
+N C G C + +G + C C++GF G C +I+DC +PC NGGTCID VN + C+C
Sbjct: 596 SNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCIC 655
Query: 1073 LPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCR 1117
+ G++CE + C Q C+ R D DC+
Sbjct: 656 SDGWEGAYCETNINDCS------QNPCHNGGTCRDLVNDFYCDCK 694
Score = 76.3 bits (186), Expect = 2e-13
Identities = 30/79 (37%), Positives = 42/79 (53%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +NPCL+GG C + C C GF+G C++DID C +PC+NG C + + +
Sbjct: 489 DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C Y G C + C
Sbjct: 549 CKCPEDYEGKNCSHLKDHC 567
Score = 67.4 bits (163), Expect = 9e-11
Identities = 28/76 (36%), Positives = 39/76 (51%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E + + C NPC +GGTC + C C G+ G+ C C + C NGGTC DE
Sbjct: 665 ETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEG 724
Query: 1066 NGFVCLCLPSYGGSFC 1081
+ F C+C + G+ C
Sbjct: 725 DAFKCMCPGGWEGTTC 740
Score = 52.8 bits (125), Expect = 2e-06
Identities = 30/118 (25%), Positives = 44/118 (37%), Gaps = 28/118 (23%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCE------------- 1056
D CE NPC +G C + Y C C + + G+NC D C +PCE
Sbjct: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASND 586
Query: 1057 --------------NGGTCIDEVNG-FVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
G C + G F C C + G++C ++ C+ + G C
Sbjct: 587 TPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTC 644
Score = 37.7 bits (86), Expect = 0.073
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 15/82 (18%)
Query: 1012 CENNPCLHG-----GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN 1066
C C G G+C G C C G+ G C D C+ P G C +
Sbjct: 229 CNRAICRQGCSPKHGSCKLPGD---CRCQYGWQGLYC----DKCIPHPGCVHGICNEP-- 279
Query: 1067 GFVCLCLPSYGGSFCEKDTEGC 1088
+ CLC ++GG C+KD C
Sbjct: 280 -WQCLCETNWGGQLCDKDLNYC 300
Score = 36.6 bits (83), Expect = 0.16
Identities = 20/68 (29%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 1007 VHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENC-EIDIDDCLC--SPCENGGTCID 1063
++ + C+++PC G TC Y C C G +G C E+ C+ S +G D
Sbjct: 819 ININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDD 878
Query: 1064 EVNGFVCL 1071
+ N CL
Sbjct: 879 DCNTCQCL 886
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 89.7 bits (221), Expect = 2e-17
Identities = 32/78 (41%), Positives = 51/78 (65%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C +NPC +GG+C+ + + C C G++G C +DID+C +PC GGTC+D+V+GF C+
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
Query: 1072 CLPSYGGSFCEKDTEGCD 1089
C + G+ C+ D C+
Sbjct: 411 CPEQWVGATCQLDANECE 428
Score = 83.2 bits (204), Expect = 2e-15
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query: 1008 HSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNG 1067
+++ C PC +GG C + C C GFAG +C I+ID+C SPC G TC+DE+NG
Sbjct: 789 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 848
Query: 1068 FVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSG 1121
+ C C P G C++ W + F H +W + CR G
Sbjct: 849 YRCSCPPGRAGPRCQEVIGFGRSCWSRGTP-----FPHGSSWVEDCNSCRCLDG 897
Score = 82.0 bits (201), Expect = 3e-15
Identities = 34/84 (40%), Positives = 45/84 (53%)
Query: 1017 CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSY 1076
C HGGTC Y C C +GF G +CE++ D+C SPC +GG C D +GF C C +
Sbjct: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 528
Query: 1077 GGSFCEKDTEGCDRGWHKFQGHCY 1100
G CE D + C+ + CY
Sbjct: 529 SGPLCEVDVDLCEPSPCRNGARCY 552
Score = 80.9 bits (198), Expect = 8e-15
Identities = 35/82 (42%), Positives = 43/82 (52%)
Query: 1019 HGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGG 1078
HG + G + C CD GF G C +IDDCL PC NGGTCIDEV+ F C C + G
Sbjct: 609 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEG 668
Query: 1079 SFCEKDTEGCDRGWHKFQGHCY 1100
C+ + C +G CY
Sbjct: 669 ELCDTNPNDCLPDPCHSRGRCY 690
Score = 80.9 bits (198), Expect = 8e-15
Identities = 32/77 (41%), Positives = 43/77 (55%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCL 1071
C NPC++GGTC +G + C C G+ G C + +DC PC NGG C+D VN F C
Sbjct: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 814
Query: 1072 CLPSYGGSFCEKDTEGC 1088
C P + G C + + C
Sbjct: 815 CAPGFAGPDCRINIDEC 831
Score = 78.6 bits (192), Expect = 4e-14
Identities = 33/86 (38%), Positives = 43/86 (50%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C ++PC GG C + C C QGF+G CE+D+D C SPC NG C +
Sbjct: 496 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE 555
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGCDRG 1091
+ C C +GG C E C G
Sbjct: 556 GDYYCACPDDFGGKNCSVPREPCPGG 581
Score = 76.3 bits (186), Expect = 2e-13
Identities = 32/83 (38%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
++ ++ CE PCL+ +C Y C C G+ G NC I+++DC C++GGTC D V
Sbjct: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR-GQCQHGGTCKDLV 479
Query: 1066 NGFVCLCLPSYGGSFCEKDTEGC 1088
NG+ C+C +GG CE + + C
Sbjct: 480 NGYQCVCPRGFGGRHCELERDEC 502
Score = 73.9 bits (180), Expect = 9e-13
Identities = 34/91 (37%), Positives = 42/91 (46%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C PC +GGTC + C C G+ GE C+ + +DCL PC + G C D VN F
Sbjct: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
C C + G C CD G CY
Sbjct: 698 CACDDGWKGKTCHSREFQCDAYTCSNGGTCY 728
Score = 69.7 bits (169), Expect = 2e-11
Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +NPC GGTC + C C + + G C++D ++C PC N +C + + G+
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446
Query: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
C C+P + G C + C RG + G C
Sbjct: 447 CDCIPGWKGINCHINVNDC-RGQCQHGGTC 475
Score = 68.6 bits (166), Expect = 4e-11
Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1012 CENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDD-CLCSPCENGGTCIDEVNGFVC 1070
C+ C +GGTC +G + C+C G+ G C + + CL +PC NGGTC+ F C
Sbjct: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
Query: 1071 LCLPSYGGSFCEKDTEGCD 1089
+C + G C +T C+
Sbjct: 776 ICRDGWEGRTCTHNTNDCN 794
Score = 58.5 bits (140), Expect = 4e-08
Identities = 26/76 (34%), Positives = 36/76 (47%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
+ + + C +PC G C + C+CD G+ G+ C C C NGGTC D
Sbjct: 672 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 731
Query: 1066 NGFVCLCLPSYGGSFC 1081
+ F C C P + GS C
Sbjct: 732 DTFRCACPPGWKGSTC 747
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/94 (32%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
Query: 1010 DPCENNP-CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCS-PCENGGTCID-EVN 1066
D C P C+HG + C+C+ + G C+ D++ C PC NGGTCI+ E +
Sbjct: 274 DECVPYPGCVHGSCVEP----WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329
Query: 1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
+ C C Y G CEK C G C+
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363
Score = 43.1 bits (100), Expect = 0.002
Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 1007 VHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDID---DCLC--SPCENGGTC 1061
++ D C+++PC +G TC Y CSC G AG C+ I C +P +G +
Sbjct: 826 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSW 885
Query: 1062 IDEVNGFVCL 1071
+++ N CL
Sbjct: 886 VEDCNSCRCL 895
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 11/71 (15%)
Query: 1018 LHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYG 1077
LHGG C G C C G+ G C D+C+ P G+C++ + C C ++G
Sbjct: 252 LHGG-CTVPGE---CRCSYGWQGRFC----DECVPYPGCVHGSCVEP---WQCNCETNWG 300
Query: 1078 GSFCEKDTEGC 1088
G C+KD C
Sbjct: 301 GLLCDKDLNYC 311
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 89.7 bits (221), Expect = 2e-17
Identities = 35/77 (45%), Positives = 52/77 (67%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E++ DPC N CL+G TC+++G C C GF GE C+IDI++C +PC +GG+C+D+
Sbjct: 541 ELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP 600
Query: 1066 NGFVCLCLPSYGGSFCE 1082
NG+ C C + G+ CE
Sbjct: 601 NGYNCHCPHGWVGANCE 617
Score = 85.1 bits (209), Expect = 4e-16
Identities = 37/79 (46%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +PC HG TC + GT Y C CD G+ G CE + ++CL +PC N TC D VNG+
Sbjct: 470 DFCALSPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYE 528
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C+CL Y G+ CE + C
Sbjct: 529 CVCLAEYKGTHCELYKDPC 547
Score = 81.3 bits (199), Expect = 6e-15
Identities = 35/96 (36%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 1010 DPCENNPCLHGGTC-----NANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDE 1064
D C+ PC + +C +G+ + C C G+ GE C+ ID C+ PC NG TCI
Sbjct: 351 DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISS 410
Query: 1065 VNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCY 1100
++GF C C Y GS CE+ + C + G CY
Sbjct: 411 LSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCY 446
Score = 78.6 bits (192), Expect = 4e-14
Identities = 33/79 (41%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
DPC ++PC + GTC +G + C+C GF G C ID C SPC + GTC +
Sbjct: 432 DPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYK 490
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
CLC P Y G +CE++ C
Sbjct: 491 CLCDPGYHGLYCEEEYNEC 509
Score = 70.5 bits (171), Expect = 1e-11
Identities = 29/79 (36%), Positives = 43/79 (54%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C +PC +G TC ++ + + C C +G+ G CE +D C SPC+N GTC + F
Sbjct: 394 DYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFT 453
Query: 1070 CLCLPSYGGSFCEKDTEGC 1088
C C P + G C + + C
Sbjct: 454 CNCSPGFTGPTCAQLIDFC 472
Score = 60.5 bits (145), Expect = 1e-08
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 21/104 (20%)
Query: 995 LPGTPMNAGAEEVHSDPCENNPCLHGGTCN------------ANGTMYGCSCDQGFAGEN 1042
+P P++A PC PC +GG C A Y C+C G +G N
Sbjct: 37 VPAAPLSAPG------PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGAN 90
Query: 1043 CEIDIDDCLCSPCENG---GTCIDEVNGFVCLCLPSYGGSFCEK 1083
C++ D C +PC +G + +G++C+C Y G CE+
Sbjct: 91 CQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 11/90 (12%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGT--MYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCID 1063
E H++ E C G C + + C+C++ + G CE + D C PC+N +CID
Sbjct: 311 ESHANDLE---CSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCID 366
Query: 1064 -----EVNGFVCLCLPSYGGSFCEKDTEGC 1088
+ + F C+CLP Y G C+ + C
Sbjct: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYC 396
Score = 48.1 bits (113), Expect = 5e-05
Identities = 17/42 (40%), Positives = 25/42 (59%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDI 1047
++ + C++NPC HGG+C Y C C G+ G NCEI +
Sbjct: 579 DIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 88.6 bits (218), Expect = 4e-17
Identities = 36/80 (45%), Positives = 45/80 (56%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C ++PC +G C G Y C C GF+G +C+ ++DDC SPC NGGTC D VN F
Sbjct: 407 DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFS 466
Query: 1070 CLCLPSYGGSFCEKDTEGCD 1089
C C P Y G C C+
Sbjct: 467 CTCPPGYTGRNCSAPVSRCE 486
Score = 79.7 bits (195), Expect = 2e-14
Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 1014 NNPCLHGGTCNANGT-MYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLC 1072
+ PC +G TC G Y CSC G+ G CE+ ID+C SPC+NGG+C D N + C C
Sbjct: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTC 354
Query: 1073 LPSYGGSFCEKDTEGCDRG 1091
P + G CE C G
Sbjct: 355 PPGFYGKICELSAMTCADG 373
Score = 75.5 bits (184), Expect = 3e-13
Identities = 28/73 (38%), Positives = 40/73 (54%)
Query: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
D C ++PC +GGTC + C+C G+ G NC + C +PC NG TC + + +V
Sbjct: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYV 504
Query: 1070 CLCLPSYGGSFCE 1082
C C YGG C+
Sbjct: 505 CECARGYGGPNCQ 517
Score = 74.7 bits (182), Expect = 5e-13
Identities = 30/84 (35%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTM-YGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDE 1064
E+ + C + PC +GG C+ + Y C C G++G NCE ID C SPC NG C+D
Sbjct: 364 ELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL 423
Query: 1065 VNGFVCLCLPSYGGSFCEKDTEGC 1088
+ ++C C + G C+ + + C
Sbjct: 424 GDAYLCRCQAGFSGRHCDDNVDDC 447
Score = 74.3 bits (181), Expect = 7e-13
Identities = 33/84 (39%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 1006 EVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEV 1065
E+ D C+ +PC +GG+C Y C+C GF G+ CE+ C PC NGG C D
Sbjct: 326 ELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSP 385
Query: 1066 N-GFVCLCLPSYGGSFCEKDTEGC 1088
+ G+ C C Y G CEK + C
Sbjct: 386 DGGYSCRCPVGYSGFNCEKKIDYC 409
Score = 61.2 bits (147), Expect = 6e-09
Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 1008 HSDPCENNP-CLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLC-SPCENGGTCIDEV 1065
+ D C P CLHG TC + C+C +G+ G C D++ C PC+NG TC +
Sbjct: 253 YCDECIRYPGCLHG-TCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTG 308
Query: 1066 NG-FVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHC 1099
G + C C P Y G+ CE + CD K G C
Sbjct: 309 QGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,528,515
Number of Sequences: 37866
Number of extensions: 3792911
Number of successful extensions: 22462
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 389
Number of HSP's successfully gapped in prelim test: 1002
Number of HSP's that attempted gapping in prelim test: 14101
Number of HSP's gapped (non-prelim): 6449
length of query: 1321
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1207
effective length of database: 13,930,794
effective search space: 16814468358
effective search space used: 16814468358
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.