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Search of human proteins with 118582255
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
(1581 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 3113 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 2116 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 2084 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 2060 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 760 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 716 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 709 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 674 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 670 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 647 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 643 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 633 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 610 e-174
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 608 e-173
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 595 e-170
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 565 e-160
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 565 e-160
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 518 e-146
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 507 e-143
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 458 e-128
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 332 1e-90
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 285 3e-76
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 218 5e-56
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 207 6e-53
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 202 2e-51
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 200 8e-51
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 185 3e-46
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 181 4e-45
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 168 4e-41
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 148 5e-35
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 3113 bits (8070), Expect = 0.0
Identities = 1581/1581 (100%), Positives = 1581/1581 (100%)
Query: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI
Sbjct: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
Query: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS
Sbjct: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
Query: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG
Sbjct: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
Query: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA
Sbjct: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
Query: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV
Sbjct: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
Query: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV
Sbjct: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
Query: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL
Sbjct: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
Query: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK
Sbjct: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
Query: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT
Sbjct: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
Query: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST
Sbjct: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
Query: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLT 660
VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLT
Sbjct: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLT 660
Query: 661 GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS 720
GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS
Sbjct: 661 GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS 720
Query: 721 SLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLN 780
SLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLN
Sbjct: 721 SLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLN 780
Query: 781 ATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA 840
ATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA
Sbjct: 781 ATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA 840
Query: 841 RALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 900
RALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII
Sbjct: 841 RALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 900
Query: 901 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMS 960
AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMS
Sbjct: 901 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMS 960
Query: 961 SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQL 1020
SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQL
Sbjct: 961 SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQL 1020
Query: 1021 LKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLV 1080
LKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLV
Sbjct: 1021 LKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLV 1080
Query: 1081 TSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1140
TSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE
Sbjct: 1081 TSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1140
Query: 1141 CLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLL 1200
CLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLL
Sbjct: 1141 CLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLL 1200
Query: 1201 SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVL 1260
SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVL
Sbjct: 1201 SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVL 1260
Query: 1261 IAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT 1320
IAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT
Sbjct: 1261 IAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT 1320
Query: 1321 EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRT 1380
EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRT
Sbjct: 1321 EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRT 1380
Query: 1381 GSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD 1440
GSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD
Sbjct: 1381 GSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD 1440
Query: 1441 PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS 1500
PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS
Sbjct: 1441 PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS 1500
Query: 1501 IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFD 1560
IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFD
Sbjct: 1501 IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFD 1560
Query: 1561 KPEKLLSRKDSVFASFVRADK 1581
KPEKLLSRKDSVFASFVRADK
Sbjct: 1561 KPEKLLSRKDSVFASFVRADK 1581
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 2116 bits (5483), Expect = 0.0
Identities = 1077/1581 (68%), Positives = 1280/1581 (80%), Gaps = 34/1581 (2%)
Query: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
M L+FCG N+ ++Y ++ GVL N CFVDALN+VPHVFLLFITFPILFIGWGSQSSKV I
Sbjct: 1 MSLSFCG--NNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQI 58
Query: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
HH+TWLHFPGHNLRWILTF LLFV VCEIAEGI+SD ES HLHL+MPA M F+A TS
Sbjct: 59 HHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTS 118
Query: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
+VYYHNIETSNFPKLL+AL +YW +AFITKTIK VK+ + S LRFC+TG++VIL G
Sbjct: 119 IVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNG 178
Query: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
+L+ VE+NVIRVRRY+FF P++VKPPEDLQDLGVRFLQPFVNLLSK TYWWMN I +A
Sbjct: 179 LLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISA 238
Query: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
HKKPIDL+AIGKLPIAMRA+TNY L +A++ Q +K +IW A+ AFGR ++
Sbjct: 239 HKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL 298
Query: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
LSSTFR LADLLGFAGPLCI GIV + + + T +SS+EFL NAYVLAV
Sbjct: 299 LSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET--LSSKEFLENAYVLAV 356
Query: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
LLFLAL+LQRTFLQASYYV IETGINLRGA+ IYNKI+ LSTSNLSMGEMT GQI NL
Sbjct: 357 LLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 416
Query: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
VAI+TNQLMWF FLCPNLWAMPVQII+GVILLY +LG SAL+GAAVI+LLAP+QYF+ATK
Sbjct: 417 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATK 476
Query: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
L++AQ+STL+YS ERLK+TNE+L+GIKLLKLYAWE+IF VE TR KE++SL+ FA+YT
Sbjct: 477 LAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYT 536
Query: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
S+SIFMN AIPIAAVL TFV H ++ + P+ AFASLSLFHILVTPLFLLS+VVR
Sbjct: 537 SLSIFMNAAIPIAAVLATFVTH-AYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA 595
Query: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPT-PQGPASKYQAVPLRVVNRKRPAREDCRGL 659
VKA++SVQKL+EFL S EI ++ E + P K+ V + +NRK+P R
Sbjct: 596 VKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSY 655
Query: 660 TGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGK 719
+ L P+ + ++ +++ GYF+W G+ TLSNI IRIP GQLTMIVGQVGCGK
Sbjct: 656 EQSTRRLRPA---ETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGK 711
Query: 720 SSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLL 779
SSLLLA LGEMQ + G V WS++ +SE PS E + R R VAYA+QKPWLL
Sbjct: 712 SSLLLAILGEMQTLEGKVHWSNVNESE----PSFEATRS-----RNRYSVAYAAQKPWLL 762
Query: 780 NATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISV 839
NATVEENI F SPFNKQRYK V +ACSLQPDID+LP GDQT+IGERGINLSGGQRQRI V
Sbjct: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 840 ARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI 899
ARALYQ+ N+VFLDDPFSALDIHLSDHLMQ GIL+ L+DDKRT+VLVTHKLQYL HADWI
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
Query: 900 IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAM 959
IAMKDG++ REGTLKD Q + +L+EHWKTLMNRQDQELEK+ ++ E + L RAM
Sbjct: 883 IAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLER-KTLRRAM 941
Query: 960 SSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQ 1019
SR+ Q E+E+EEE E +EDDN+S+++ R ++PW+ C +YL+S G LL L++FS+
Sbjct: 942 YSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSK 1001
Query: 1020 LLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCL 1079
LLKH V+VAIDYWLA WT S++ DQT Y F++LC GI LCL
Sbjct: 1002 LLKHSVIVAIDYWLATWTSEY----------SINNTGKADQTYYVAGFSILCGAGIFLCL 1051
Query: 1080 VTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTL 1139
VTS+TVEW GL AK LH +LLN+IIL P+RFF+TTPLG ILNRFS+D N IDQHIP TL
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
Query: 1140 ECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPL 1199
E L+RSTLLC+SA+ +ISY TPVFLVALLPL + YFIQKYFRVAS+DLQ+LDD+TQLPL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
Query: 1200 LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVV 1259
L HF+ET EGLTTIRAFR+E RF+Q++LE TD+NNIA LFL+AANRWLEVR +Y+GAC+V
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 1260 LIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLK 1319
L A++ SIS S + +GLVGLGL YAL ++NYLNW+VRNLAD+E+Q+GAVK+++ L
Sbjct: 1232 LTASIASISGSSN----SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLT 1287
Query: 1320 TEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGR 1379
E+E+YEG + PS +P++WP +G+I+I +L VRY+++LKPVLKHV A I PGQK+GICGR
Sbjct: 1288 MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGR 1347
Query: 1380 TGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL 1439
TGSGKSS SLAFFRMVD F+G I+IDGIDI+KLPLHTLRSRLSIILQDP+LFSG+IRFNL
Sbjct: 1348 TGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL 1407
Query: 1440 DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKT 1499
DPE KC+D LWEALEIAQLK +VK+LPGGLDA++TEGGENFS GQRQLFCLARAFVRK+
Sbjct: 1408 DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKS 1467
Query: 1500 SIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEF 1559
SI IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTIL+ADLVIV+KRG ILE+
Sbjct: 1468 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEY 1527
Query: 1560 DKPEKLLSRKDSVFASFVRAD 1580
D PE LL++++ VFASFVRAD
Sbjct: 1528 DTPESLLAQENGVFASFVRAD 1548
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 2084 bits (5400), Expect = 0.0
Identities = 1061/1582 (67%), Positives = 1268/1582 (80%), Gaps = 34/1582 (2%)
Query: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
M L+FCG N+ ++Y ++ GVL N CFVDALN+VPHVFLLFITFPILFIGWGSQSSKV I
Sbjct: 1 MSLSFCG--NNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQI 58
Query: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
HH+TWLHFPGHNLRWILTF LLFV VCEIAEGI+SD ES HLHL+MPA M F+A TS
Sbjct: 59 HHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTS 118
Query: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
+VYYHNIETSNFPKLL+AL +YW +AFITKTIK VK+ + S LRFC+TG++VIL G
Sbjct: 119 IVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNG 178
Query: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
+L+ VE+NVIRVRRY+FF P++VKPPEDLQDLGVRFLQPFVNLLSK TYWWMN I +A
Sbjct: 179 LLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISA 238
Query: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
HKKPIDL+AIGKLPIAMRA+TNY L +A++ Q +K +IW A+ AFGR ++
Sbjct: 239 HKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL 298
Query: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
LSSTFR LADLLGFAGPLCI GIV + + + T +SS+EFL NAYVLAV
Sbjct: 299 LSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET--LSSKEFLENAYVLAV 356
Query: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
LLFLAL+LQRTFLQASYYV IETGINLRGA+ IYNKI+ LSTSNLSMGEMT GQI NL
Sbjct: 357 LLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 416
Query: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
VAI+TNQLMWF FLCPNLWAMPVQII+GVILLY +LG SAL+GAAVI+LLAP+QYF+ATK
Sbjct: 417 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATK 476
Query: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
L++AQ+STL+YS ERLK+TNE+L+GIKLLKLYAWE+IF VE TR KE++SL+ FA+YT
Sbjct: 477 LAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYT 536
Query: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
S+SIFMN AIPIAAVL TFV H ++ + P+ AFASLSLFHILVTPLFLLS+VVR
Sbjct: 537 SLSIFMNAAIPIAAVLATFVTH-AYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA 595
Query: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPT-PQGPASKYQAVPLRVVNRKRPAREDCRGL 659
VKA++SVQKL+EFL S EI ++ E + P K+ V + +NRK+P R
Sbjct: 596 VKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSY 655
Query: 660 TGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGK 719
+ L P+ + ++ +++ GYF+W G+ TLSNI IRIP GQLTMIVGQVGCGK
Sbjct: 656 EQSTRRLRPA---ETEDIAIKVTNGYFSW-GSGLATLSNIDIRIPTGQLTMIVGQVGCGK 711
Query: 720 SSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLL 779
SSLLLA LGEMQ + G V WS++ +SE PS E + R R VAYA+QKPWLL
Sbjct: 712 SSLLLAILGEMQTLEGKVHWSNVNESE----PSFEATRS-----RNRYSVAYAAQKPWLL 762
Query: 780 NATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISV 839
NATVEENI F SPFNKQRYK V +ACSLQPDID+LP GDQT+IGERGINLSGGQRQRI V
Sbjct: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 840 ARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI 899
ARALYQ+ N+VFLDDPFSALDIHLSDHLMQ GIL+ L+DDKRT+VLVTHKLQYL HADWI
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
Query: 900 IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAM 959
IAMKDG++ REGTLKD Q + +L+EHWKTLMNRQDQELEK+ ++ E + L RAM
Sbjct: 883 IAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLE-RKTLRRAM 941
Query: 960 SSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQ 1019
SR+ Q E+E+EEE E +EDDN+S+++ R ++PW+ C +YL+S G LL L++FS+
Sbjct: 942 YSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSK 1001
Query: 1020 LLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCL 1079
LLKH V+VAIDYWLA WT S++ DQT Y F++LC GI LCL
Sbjct: 1002 LLKHSVIVAIDYWLATWTS----------EYSINNTGKADQTYYVAGFSILCGAGIFLCL 1051
Query: 1080 VTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTL 1139
VTS+TVEW GL AK LH +LLN+IIL P+RFF+TTPLG ILNRFS+D N IDQHIP TL
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
Query: 1140 ECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPL 1199
E L+RSTLLC+SA+ +ISY TPVFLVALLPL + YFIQKYFRVAS+DLQ+LDD+TQLPL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
Query: 1200 LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVV 1259
L HF+ET EGLTTIRAFR+E RF+Q++LE TD+NNIA LFL+AANRWLEVR +Y+GAC+V
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 1260 LIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLK 1319
L A++ SIS S ++GLVGLGL YAL ++NYLNW+VRNLAD+E+Q+GAVK+++ L
Sbjct: 1232 LTASIASISGS----SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLT 1287
Query: 1320 TEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGR 1379
E+E+YEG + PS +P++WP +G+I+I +L VRY+++LKPVLKHV A I PGQK+GICGR
Sbjct: 1288 MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGR 1347
Query: 1380 TGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL 1439
TGSGKSS SLAFFRMVD F+G I+IDGIDI+KLPLHTLRSRLSIILQDP+LFSG+IRFNL
Sbjct: 1348 TGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL 1407
Query: 1440 DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKT 1499
DPE KC+D LWEALEIAQLK +VK+LPGGLDA++TEGGENFS GQRQLFCLARAFVRK+
Sbjct: 1408 DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKS 1467
Query: 1500 SIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEF 1559
SI IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV +I+ A LV+V G ++E
Sbjct: 1468 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVEC 1527
Query: 1560 DKPEKLLSRKDSVFASFVRADK 1581
D LL+ K+ +F++ V +K
Sbjct: 1528 DTVPNLLAHKNGLFSTLVMTNK 1549
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 2060 bits (5338), Expect = 0.0
Identities = 1056/1581 (66%), Positives = 1254/1581 (79%), Gaps = 68/1581 (4%)
Query: 1 MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHI 60
M L+FCG N+ ++Y ++ GVL N CFVDALN+VPHVFLLFITFPILFIGWGSQSSKV I
Sbjct: 1 MSLSFCG--NNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQI 58
Query: 61 HHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTS 120
HH+TWLHFPGHNLRWILTF LLFV VCEIAEGI+SD ES HLHL+MPA M F+A TS
Sbjct: 59 HHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTS 118
Query: 121 VVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYG 180
+VYYHNIETSNFPKLL+AL +YW +AFITKTIK VK+ + S LRFC+TG++VIL G
Sbjct: 119 IVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNG 178
Query: 181 MLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTA 240
+L+ VE+NVIRVRRY+FF P++VKPPEDLQDLGVRFLQPFVNLLSK TYWWMN I +A
Sbjct: 179 LLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISA 238
Query: 241 HKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLV 300
HKKPIDL+AIGKLPIAMRA+TNY L +A++ Q +K +IW A+ AFGR ++
Sbjct: 239 HKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL 298
Query: 301 LSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAV 360
LSSTFR LADLLGFAGPLCI GIV + + + T +SS+EFL NAYVLAV
Sbjct: 299 LSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET--LSSKEFLENAYVLAV 356
Query: 361 LLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNL 420
LLFLAL+LQRTFLQASYYV IETGINLRGA+ IYNKI+ LSTSNLSMGEMT GQI NL
Sbjct: 357 LLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 416
Query: 421 VAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480
VAI+TNQLMWF FLCPNLWAMPVQII+GVILLY +LG SAL+GAAVI+LLAP+QYF+ATK
Sbjct: 417 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATK 476
Query: 481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYT 540
L++AQ+STL+YS ERLK+TNE+L+GIKLLKLYAWE+IF VE TR KE++SL+ FA+YT
Sbjct: 477 LAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYT 536
Query: 541 SISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRST 600
S+SIFMN AIPIAAVL TFV H ++ + P+ AFASLSLFHILVTPLFLLS+VVR
Sbjct: 537 SLSIFMNAAIPIAAVLATFVTH-AYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA 595
Query: 601 VKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLT 660
VKA++SVQKL+EFL S EI ++ E ++P E C+ T
Sbjct: 596 VKAIISVQKLNEFLLSDEIGDDSWRTGE----------SSLPF----------ESCKKHT 635
Query: 661 GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS 720
G + GYF+W G+ TLSNI IRIP GQLTMIVGQVGCGKS
Sbjct: 636 GV------------------VTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKS 676
Query: 721 SLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLN 780
SLLLA LGEMQ + G V WS++ +SE PS E + R R VAYA+QKPWLLN
Sbjct: 677 SLLLAILGEMQTLEGKVHWSNVNESE----PSFEATRS-----RNRYSVAYAAQKPWLLN 727
Query: 781 ATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA 840
ATVEENI F SPFNKQRYK V +ACSLQPDID+LP GDQT+IGERGINLSGGQRQRI VA
Sbjct: 728 ATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVA 787
Query: 841 RALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 900
RALYQ+ N+VFLDDPFSALDIHLSDHLMQ GIL+ L+DDKRT+VLVTHKLQYL HADWII
Sbjct: 788 RALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWII 847
Query: 901 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMS 960
AMKDG++ REGTLKD Q + +L+EHWKTLMNRQDQELEK+ ++ E + L RAM
Sbjct: 848 AMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLER-KTLRRAMY 906
Query: 961 SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQL 1020
SR+ Q E+E+EEE E +EDDN+S+++ R ++PW+ C +YL+S G LL L++FS+L
Sbjct: 907 SREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKL 966
Query: 1021 LKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLV 1080
LKH V+VAIDYWLA WT S++ DQT Y F++LC GI LCLV
Sbjct: 967 LKHSVIVAIDYWLATWTSEY----------SINNTGKADQTYYVAGFSILCGAGIFLCLV 1016
Query: 1081 TSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1140
TS+TVEW GL AK LH +LLN+IIL P+RFF+TTPLG ILNRFS+D N IDQHIP TLE
Sbjct: 1017 TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLE 1076
Query: 1141 CLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLL 1200
L+RSTLLC+SA+ +ISY TPVFLVALLPL + YFIQKYFRVAS+DLQ+LDD+TQLPLL
Sbjct: 1077 SLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1136
Query: 1201 SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVL 1260
HF+ET EGLTTIRAFR+E RF+Q++LE TD+NNIA LFL+AANRWLEVR +Y+GAC+VL
Sbjct: 1137 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVL 1196
Query: 1261 IAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT 1320
A++ SIS S + +GLVGLGL YAL ++NYLNW+VRNLAD+E+Q+GAVK+++ L
Sbjct: 1197 TASIASISGSSN----SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTM 1252
Query: 1321 EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRT 1380
E+E+YEG + PS +P++WP +G+I+I +L VRY+++LKPVLKHV A I PGQK+GICGRT
Sbjct: 1253 ESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1312
Query: 1381 GSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD 1440
GSGKSS SLAFFRMVD F+G I+IDGIDI+KLPLHTLRSRLSIILQDP+LFSG+IRFNLD
Sbjct: 1313 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD 1372
Query: 1441 PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS 1500
PE KC+D LWEALEIAQLK +VK+LPGGLDA++TEGGENFS GQRQLFCLARAFVRK+S
Sbjct: 1373 PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSS 1432
Query: 1501 IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFD 1560
I IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV +I+ A LV+V G ++E D
Sbjct: 1433 ILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECD 1492
Query: 1561 KPEKLLSRKDSVFASFVRADK 1581
LL+ K+ +F++ V +K
Sbjct: 1493 TVPNLLAHKNGLFSTLVMTNK 1513
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 760 bits (1962), Expect = 0.0
Identities = 474/1412 (33%), Positives = 744/1412 (52%), Gaps = 172/1412 (12%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
Query: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Q K + ++ ++++ L FG ++S
Sbjct: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Query: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
Query: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
Query: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
Query: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
VS+++L FLS E+ + +RP +
Sbjct: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
Query: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 637 ------DGGGTNS-ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 725 AALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVE 784
A L EM KV G V +G VAY Q+ W+ N ++
Sbjct: 690 ALLAEMDKVEGHV--------------------------AIKGSVAYVPQQAWIQNDSLR 723
Query: 785 ENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALY 844
ENI+F + Y+ VI+AC+L PD++ILP GD+T+IGE+G+NLSGGQ+QR+S+ARA+Y
Sbjct: 724 ENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
Query: 845 QHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD 904
+A++ DDP SA+D H+ H+ + I +T +LVTH + YLP D II M
Sbjct: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
Query: 905 GTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETVTE-----RKATEPPQG---- 954
G I G+ ++ + E +T + Q+Q+ E+ VT ++A + G
Sbjct: 844 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVT 903
Query: 955 ------LSRAMSSRDGLLQD--------EEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
L R +SS D E ++ EA + E + + Q ++
Sbjct: 904 DSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVY 963
Query: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQ 1060
Y+ + G+ + L +F + H+ +A +YWL+ WTD + + +QE T
Sbjct: 964 WDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIV--------NGTQEHT--- 1012
Query: 1061 TVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPL 1117
+ +V +LGI + S+ V G+ ++ LH LL+ I+ +PM FFE TP
Sbjct: 1013 ---KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPS 1069
Query: 1118 GSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFI 1177
G+++NRFS + +T+D IP ++ S + A VI TP+ + + PL ++ +F+
Sbjct: 1070 GNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV 1129
Query: 1178 QKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1237
Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF + RF + D N A
Sbjct: 1130 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1189
Query: 1238 LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297
ANRWL VR+E +G C+VL AA+ ++ + LSAGLVGL ++Y+L V+ YLNW+
Sbjct: 1190 YPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSAGLVGLSVSYSLQVTTYLNWL 1247
Query: 1298 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL 1357
VR ++ME + AV+R+ +TE E+ + + P +WP G+++ +N +RY L
Sbjct: 1248 VRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDL 1306
Query: 1358 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417
VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++ EG IIIDGI+IAK+ LH L
Sbjct: 1307 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1366
Query: 1418 RSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEG 1477
R +++II QDPVLFSG++R NLDP + SD +W +LE+A LK V ALP LD EG
Sbjct: 1367 RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEG 1426
Query: 1478 GENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAH 1537
GEN S GQRQL CLARA +RKT I ++DEATA++D+ T++++Q + T F D TV+TIAH
Sbjct: 1427 GENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAH 1486
Query: 1538 RVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
R++TI+ VIVL +G I E+ P LL ++
Sbjct: 1487 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1518
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 716 bits (1847), Expect = 0.0
Identities = 470/1421 (33%), Positives = 736/1421 (51%), Gaps = 197/1421 (13%)
Query: 225 LSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVR--------- 275
LS+ +WW ++ P++ + + L R+ Q+L EA+ Q +
Sbjct: 215 LSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASA 274
Query: 276 ---KDIQGTQ----GAR------AIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFG 322
K+ G GAR + +AL FG ++S+ F+++ DLL F P
Sbjct: 275 APGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINP----- 329
Query: 323 IVDHLGKENDVFQPKTQFLGVYFVSSQEFLAN-------AYVLAVLLFLALLLQRTFLQA 375
Q L + F++N +++A L+FL ++Q LQ
Sbjct: 330 ----------------QLLSILI----RFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
Query: 376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLC 435
Y+ TG+ R I IY K + ++ S T G+I NL+++D + M
Sbjct: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRAS--TVGEIVNLMSVDAQRFMDLAPFL 427
Query: 436 PNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNER 495
LW+ P+QII+ + L+ LG S L G A ++LL P+ VA K+ Q ++ + R
Sbjct: 428 NLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSR 487
Query: 496 LKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAV 555
+K +E+L GIK+LKLYAWE F +VE R+ E+ LR A + + F P
Sbjct: 488 IKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVT 547
Query: 556 LITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLS 615
LIT +V AF S+SLF+IL PL +L ++ + +A VS++++ +FLS
Sbjct: 548 LITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLS 607
Query: 616 SAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDAD 675
E+ PQ V RK ++ P
Sbjct: 608 QEEL----------DPQS------------VERK---------------TISPGY----- 625
Query: 676 NCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSG 735
+ I G FTW D PTL ++ I++P+G L +VG VGCGKSSL+ A LGEM+K+ G
Sbjct: 626 --AITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG 683
Query: 736 AVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK 795
V +G VAY Q+ W+ N T++EN++F N
Sbjct: 684 KV--------------------------HMKGSVAYVPQQAWIQNCTLQENVLFGKALNP 717
Query: 796 QRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDP 855
+RY+ +EAC+L D+++LP GDQT+IGE+GINLSGGQRQR+S+ARA+Y A++ LDDP
Sbjct: 718 KRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDP 777
Query: 856 FSALDIHLSDHLMQ-----AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI--- 907
SA+D H++ H+ G+L +T VLVTH + +LP D+II + DG +
Sbjct: 778 LSAVDSHVAKHIFDHVIGPEGVLA-----GKTRVLVTHGISFLPQTDFIIVLADGQVSEM 832
Query: 908 -------QREGTLKDF------QRSECQLFEHWKTLMNRQDQE--LEKETV---TERKAT 949
QR G+ +F + L + W L +D+E L ++T+ T+
Sbjct: 833 GPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDN 892
Query: 950 EPPQGL--SRAMSSRDGLLQDEE-------------EEEEEAAESEEDDNLSSMLHQRAE 994
+P + + M L D E E+ + E++ D L+ ++A
Sbjct: 893 DPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQ--EEKAA 950
Query: 995 IPWRACA---KYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCS 1051
I + Y + G+ + + + + + WL+ WT+ A+ S
Sbjct: 951 IGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMA-------DS 1003
Query: 1052 LSQECTLDQTVYAMVFTVLCSLGIV---LCLVTSVTVEWTGLKVAKRLHRSLLNRIILAP 1108
+L VYA +LGI+ L ++ ++ + G++ A+ LH++LL+ I +P
Sbjct: 1004 RQNNTSLRLGVYA-------ALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSP 1056
Query: 1109 MRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALL 1168
FF+TTP G ILN FS D +D+ + + L S +S L VI TP+F V +L
Sbjct: 1057 QSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVIL 1116
Query: 1169 PLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLE 1228
PLA++ +Q+++ SR L++L+ ++ P+ SHF+ETV G + IRA+ F+
Sbjct: 1117 PLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDT 1176
Query: 1229 YTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
D+N + +NRWL + +E++G CVVL AA+ ++ L+ GLVGL ++Y+L
Sbjct: 1177 KVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIG--RSSLNPGLVGLSVSYSL 1234
Query: 1289 MVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQN 1348
V+ LNWM+R ++D+E + AV+R+ KTE E+ ++ S P+ WP +G+++ +N
Sbjct: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEA-PWVVEGSRPPEGWPPRGEVEFRN 1293
Query: 1349 LSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGID 1408
SVRY L VL+ ++ + G+K+GI GRTG+GKSS +L FR+++ +G I IDG++
Sbjct: 1294 YSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 1409 IAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPG 1468
+A + LH LRS+L+II QDP+LFSGT+R NLDP S+ +W ALE++ L V + P
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPA 1413
Query: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
GLD +EGGEN S GQRQL CLARA +RK+ I ++DEATA+ID+ T+N++Q + T F
Sbjct: 1414 GLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFD 1473
Query: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
TV+TIAHR++TI+ V+VL +G + EFD P L++ +
Sbjct: 1474 TCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR 1514
Score = 87.8 bits (216), Expect = 7e-17
Identities = 107/427 (25%), Positives = 176/427 (41%), Gaps = 47/427 (11%)
Query: 1163 FLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARF 1222
F+V L+PL + F+V L+ +++ L+S E + G+ ++ + +E F
Sbjct: 458 FMVLLIPLNGAVAVKMRAFQVKQMKLKD----SRIKLMS---EILNGIKVLKLYAWEPSF 510
Query: 1223 QQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSI--------SNSLHRE 1274
L+ + L L +L + C + + ++ +N L E
Sbjct: 511 ----LKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAE 566
Query: 1275 LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLI 1334
+ V L L + N L ++ NL + L KRI L E L P +
Sbjct: 567 KAFVSVSLFNILRLPL-NMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSV 616
Query: 1335 PKNWPDQG-KIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFR 1393
+ G I I + + + L P L ++ + G + + G G GKSS A
Sbjct: 617 ERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
Query: 1394 MVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEA 1453
++ EG + + G +A +P + LQ+ VLF L+P+R +
Sbjct: 677 EMEKLEGKVHMKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPKR------YQQT 723
Query: 1454 LEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM 1513
LE L ++ LPGG I E G N S GQRQ LARA IF++D+ +++D
Sbjct: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
Query: 1514 -ATENILQKVV--MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKD 1570
++I V+ A +T V + H + + D +IVL G + E LL R
Sbjct: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
Query: 1571 SVFASFV 1577
S FA+F+
Sbjct: 844 S-FANFL 849
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 709 bits (1831), Expect = 0.0
Identities = 468/1504 (31%), Positives = 750/1504 (49%), Gaps = 189/1504 (12%)
Query: 139 LLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFF 198
L ++W L+ + T +F + + + L I YG +L+ + F
Sbjct: 132 LSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSA------FS 185
Query: 199 KTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMR 258
+ P + + LS TY W ++ I +K+P+ L + ++ M+
Sbjct: 186 ENNESSNNPSSI-----------ASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
Query: 259 ALTNYQRLCEAFDAQVRKDIQGTQGA--RAIWQALSHAFGRRLV-------LSSTFRILA 309
T L F+ +++++Q + A R ++ G RL S +L
Sbjct: 235 TKT----LVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLE 290
Query: 310 DL------LGFAGPLCIFGIVDHLGKE--------------NDVF---QPKTQFLGVYFV 346
D+ G + ++ L K ND+F P+ L + F
Sbjct: 291 DVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFA 350
Query: 347 SSQE-FLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405
S ++ +L Y+ A+LLF A L+Q LQ + + + G+ +R AI +Y K + LS
Sbjct: 351 SDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLS-- 408
Query: 406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAA 465
NL+ E T G+ NL+++D +LM LW+ +QI++ + L+ LG S L G
Sbjct: 409 NLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVG 468
Query: 466 VIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETT 525
V++L+ P+ ++TK Q ++ ++RLK NE+L GIK+LK +AWE FR +V+
Sbjct: 469 VMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNL 528
Query: 526 RRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHI 585
R+KE+ +L AF+ + IF+ P+ ++TF +V AF S++LF+I
Sbjct: 529 RKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNI 588
Query: 586 LVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRV 645
L PL +L ++ S ++A VS ++L ++L ++
Sbjct: 589 LRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAI--------------------- 627
Query: 646 VNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPR 705
R DC + +Q FTW D T+ ++ + I
Sbjct: 628 -------RHDCNF-----------------DKAMQFSEASFTWEHDSEATVRDVNLDIMA 663
Query: 706 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRK 765
GQL ++G VG GKSSL+ A LGEM+ V G I
Sbjct: 664 GQLVAVIGPVGSGKSSLISAMLGEMENVHG--------------------------HITI 697
Query: 766 RGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGER 825
+G AY Q+ W+ N T+++NI+F + FN++RY+ V+EAC+L PD+++LP GD +IGE+
Sbjct: 698 KGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEK 757
Query: 826 GINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA--GILELLRDDKRTV 883
GINLSGGQ+QRIS+ARA YQ+ ++ LDDP SA+D H+ H+ G LL+ +T
Sbjct: 758 GINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKG--KTR 815
Query: 884 VLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKE-- 941
+LVTH + +LP D I+ + +GTI +G+ + + ++ KT + E E
Sbjct: 816 LLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVH 875
Query: 942 ------------------------TVTERKATEPPQGLSRAMSSRDGLLQ---------- 967
++T R+ + LSR+ S L+
Sbjct: 876 DGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRN 935
Query: 968 -DEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVL 1026
+ +E+EE + ++ + + ++ + +YL + G+ + ++ + ++ +
Sbjct: 936 VNSLKEDEELVKGQK--LIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAF 993
Query: 1027 VAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVE 1086
+ + WL+ WT + S M V +LG+ + +
Sbjct: 994 IGSNLWLSAWTSDSKIFNSTDYPASQRD----------MRVGVYGALGLAQGIFVFIAHF 1043
Query: 1087 WTG---LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
W+ + + LH+ LLN I+ APMRFF+TTP G I+NRF+ D +T+D +P +L
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 1144 RSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF 1203
L +S L +I TPVF + ++PL I+ +Q ++ SR L++LD T+ P+ SHF
Sbjct: 1104 TCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHF 1163
Query: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
+ETV GL IRAF ++ RF + D+N +NRWL +R+E +G V +A
Sbjct: 1164 SETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSA 1223
Query: 1264 VTSISNSLHRE-LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEA 1322
+ + ++R+ LS VG L+ AL ++ LNW+VR +++E + AV+RI K E
Sbjct: 1224 LMMV---IYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN 1280
Query: 1323 ESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGS 1382
E+ + P +WP +GKIQ N VRY L VL+ + I +KIG+ GRTG+
Sbjct: 1281 EA--PWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGA 1338
Query: 1383 GKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPE 1442
GKSS + FR+++ G IIIDG+DIA + LH LR +L+II QDP+LFSG++R NLDP
Sbjct: 1339 GKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPF 1398
Query: 1443 RKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF 1502
SD +W+ALE+A LK V +L GL +TE G N S GQRQL CL RA +RK+ I
Sbjct: 1399 NNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKIL 1458
Query: 1503 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKP 1562
++DEATA++D+ T+N++Q + FA TV+TIAHR+HTI+ +D V+VL G I+E P
Sbjct: 1459 VLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSP 1518
Query: 1563 EKLL 1566
E+LL
Sbjct: 1519 EELL 1522
Score = 87.0 bits (214), Expect = 1e-16
Identities = 139/664 (20%), Positives = 262/664 (39%), Gaps = 69/664 (10%)
Query: 928 KTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGL--LQDEEEEEEEAAESEEDDNL 985
KTL+++ + +++E R+A + Q S +S L L + + ++A E+ +
Sbjct: 236 KTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKK 295
Query: 986 SSMLHQRAEIP--WRACAKYLSSAGILLLSLL----------VFSQLLKHMVLVAIDYWL 1033
+ ++P W A + + +LL S L V QLLK ++ A D
Sbjct: 296 KKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDT 355
Query: 1034 AKWTD--SALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLK 1091
W A+ L AA S +C LC G+K
Sbjct: 356 YLWIGYLCAILLFTAALIQSFCLQCYFQ-----------------LCFKL-------GVK 391
Query: 1092 VAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVS 1151
V + S+ + + + +G +N S D + + + + L S L V
Sbjct: 392 VRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL-MDVTNFMHMLWSSVLQIVL 450
Query: 1152 ALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLT 1211
++ + ++A + + ++ I S+ +Q + + L E + G+
Sbjct: 451 SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIK 510
Query: 1212 TIRAFRYEARFQ---QKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSIS 1268
++ F +E F+ Q L + N +A L ++ + + V V S
Sbjct: 511 ILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDS 570
Query: 1269 NSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGL 1328
N++ L A +T ++ L+ + ++ M + +R+ L +
Sbjct: 571 NNI---LDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD------ 621
Query: 1329 LAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFS 1388
L S I + +Q S ++ + ++ VN I GQ + + G GSGKSS
Sbjct: 622 LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLI 681
Query: 1389 LAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDS 1448
A ++ GHI T++ + + Q + +GTI+ N+ + ++
Sbjct: 682 SAMLGEMENVHGHI-------------TIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEK 728
Query: 1449 TLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEAT 1508
+ LE L ++ LPGG A I E G N S GQ+Q LARA + I+++D+
Sbjct: 729 RYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPL 788
Query: 1509 ASIDM-ATENILQKVV--MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKL 1565
+++D ++I KV+ +T + + H +H + D ++VL G I+E L
Sbjct: 789 SAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSAL 848
Query: 1566 LSRK 1569
L++K
Sbjct: 849 LAKK 852
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 674 bits (1739), Expect = 0.0
Identities = 447/1412 (31%), Positives = 703/1412 (49%), Gaps = 228/1412 (16%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
Query: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Q K + ++ ++++ L FG ++S
Sbjct: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Query: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
Query: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
Query: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
Query: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
VS+++L FLS E+ + +RP +
Sbjct: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
Query: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 637 ------DGGGTNS-ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 725 AALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVE 784
A L EM KV G V +G VAY Q+ W+ N ++
Sbjct: 690 ALLAEMDKVEGHV--------------------------AIKGSVAYVPQQAWIQNDSLR 723
Query: 785 ENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALY 844
ENI+F + Y+ VI+AC+L PD++ILP G R I
Sbjct: 724 ENILFGCQLEEPYYRSVIQACALLPDLEILP---------------SGDRTEIG------ 762
Query: 845 QHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD 904
++T +LVTH + YLP D II M
Sbjct: 763 -----------------------------------EKTRILVTHSMSYLPQVDVIIVMSG 787
Query: 905 GTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETVTE-----RKATEPPQG---- 954
G I G+ ++ + E +T + Q+Q+ E+ VT ++A + G
Sbjct: 788 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVT 847
Query: 955 ------LSRAMSSRDGLLQD--------EEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
L R +SS D E ++ EA + E + + Q ++
Sbjct: 848 DSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVY 907
Query: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQ 1060
Y+ + G+ + L +F + H+ +A +YWL+ WTD + + +QE T
Sbjct: 908 WDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIV--------NGTQEHT--- 956
Query: 1061 TVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPL 1117
+ +V +LGI + S+ V G+ ++ LH LL+ I+ +PM FFE TP
Sbjct: 957 ---KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPS 1013
Query: 1118 GSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFI 1177
G+++NRFS + +T+D IP ++ S + A VI TP+ + + PL ++ +F+
Sbjct: 1014 GNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV 1073
Query: 1178 QKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1237
Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF + RF + D N A
Sbjct: 1074 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1133
Query: 1238 LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297
ANRWL VR+E +G C+VL AA+ ++ + LSAGLVGL ++Y+L V+ YLNW+
Sbjct: 1134 YPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSAGLVGLSVSYSLQVTTYLNWL 1191
Query: 1298 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL 1357
VR ++ME + AV+R+ +TE E+ + + P +WP G+++ +N +RY L
Sbjct: 1192 VRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDL 1250
Query: 1358 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417
VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++ EG IIIDGI+IAK+ LH L
Sbjct: 1251 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1310
Query: 1418 RSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEG 1477
R +++II QDPVLFSG++R NLDP + SD +W +LE+A LK V ALP LD EG
Sbjct: 1311 RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEG 1370
Query: 1478 GENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAH 1537
GEN S GQRQL CLARA +RKT I ++DEATA++D+ T++++Q + T F D TV+TIAH
Sbjct: 1371 GENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAH 1430
Query: 1538 RVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
R++TI+ VIVL +G I E+ P LL ++
Sbjct: 1431 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1462
Score = 34.7 bits (78), Expect = 0.75
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 1525 TAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
T ++T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 759 TEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 811
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 670 bits (1728), Expect = 0.0
Identities = 429/1323 (32%), Positives = 680/1323 (51%), Gaps = 172/1323 (13%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
Query: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Q K + ++ ++++ L FG ++S
Sbjct: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Query: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
Query: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
Query: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
Query: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
VS+++L FLS E+ + +RP +
Sbjct: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
Query: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 637 ------DGGGTNS-ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 725 AALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVE 784
A L EM KV G V +G VAY Q+ W+ N ++
Sbjct: 690 ALLAEMDKVEGHV--------------------------AIKGSVAYVPQQAWIQNDSLR 723
Query: 785 ENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALY 844
ENI+F + Y+ VI+AC+L PD++ILP GD+T+IGE+G+NLSGGQ+QR+S+ARA+Y
Sbjct: 724 ENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
Query: 845 QHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD 904
+A++ DDP SA+D H+ H+ + I +T +LVTH + YLP D II M
Sbjct: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
Query: 905 GTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETVTE-----RKATEPPQG---- 954
G I G+ ++ + E +T + Q+Q+ E+ VT ++A + G
Sbjct: 844 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVT 903
Query: 955 ------LSRAMSSRDGLLQD--------EEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
L R +SS D E ++ EA + E + + Q ++
Sbjct: 904 DSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVY 963
Query: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQ 1060
Y+ + G+ + L +F + H+ +A +YWL+ WTD + + +QE T
Sbjct: 964 WDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIV--------NGTQEHT--- 1012
Query: 1061 TVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPL 1117
+ +V +LGI + S+ V G+ ++ LH LL+ I+ +PM FFE TP
Sbjct: 1013 ---KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPS 1069
Query: 1118 GSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFI 1177
G+++NRFS + +T+D IP ++ S + A VI TP+ + + PL ++ +F+
Sbjct: 1070 GNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV 1129
Query: 1178 QKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1237
Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF + RF + D N A
Sbjct: 1130 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1189
Query: 1238 LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297
ANRWL VR+E +G C+VL AA+ ++ + LSAGLVGL ++Y+L V+ YLNW+
Sbjct: 1190 YPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSAGLVGLSVSYSLQVTTYLNWL 1247
Query: 1298 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL 1357
VR ++ME + AV+R+ +TE E+ + + P +WP G+++ +N +RY L
Sbjct: 1248 VRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDL 1306
Query: 1358 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417
VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++ EG IIIDGI+IAK+ LH L
Sbjct: 1307 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1366
Query: 1418 RSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEG 1477
R +++II QDPVLFSG++R NLDP + SD +W +LE+A LK V ALP LD EG
Sbjct: 1367 RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEG 1426
Query: 1478 GEN 1480
GEN
Sbjct: 1427 GEN 1429
Score = 92.8 bits (229), Expect = 2e-18
Identities = 119/535 (22%), Positives = 229/535 (42%), Gaps = 56/535 (10%)
Query: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
Query: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
Query: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
Query: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I G
Sbjct: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
Query: 1407 IDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKAL 1466
+A +P Q + + ++R N+ + + ++ L ++ L
Sbjct: 707 -SVAYVP------------QQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEIL 753
Query: 1467 PGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATENILQKVV-- 1523
P G I E G N S GQ+Q LARA I++ D+ +++D ++I + V+
Sbjct: 754 PSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP 813
Query: 1524 MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
++T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 814 KGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 867
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 647 bits (1670), Expect = 0.0
Identities = 437/1398 (31%), Positives = 709/1398 (50%), Gaps = 114/1398 (8%)
Query: 224 LLSKGTYWWMNAFIKTAHKK-PIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQ 282
L S T+ W+++ + AHKK + + + L + N +RL + ++ + G
Sbjct: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE--VGPD 163
Query: 283 GA---RAIWQALSHAFGR-RLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKT 338
A R +W F R RL+LS ++ L GF+GP + V HL +
Sbjct: 164 AASLRRVVW-----IFCRTRLILSIVCLMITQLAGFSGPAFM---VKHLLE--------- 206
Query: 339 QFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNK 398
Y +++ L + +L + L L +++ L ++ + TG+ LRGAI T + K
Sbjct: 207 -----YTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKK 261
Query: 399 IMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGV 458
I+ L ++ E + G++ N+ + D ++ + L PV I+G+I ILG
Sbjct: 262 ILKLK----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGP 317
Query: 459 SALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIF 518
+ +G+AV IL P F + + +R + ++ER+++ NE+L IK +K+YAW F
Sbjct: 318 TGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAF 377
Query: 519 RTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFA 578
V+ R +E L + SI++ + + + A ++TF H++ D + + AF
Sbjct: 378 SQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTL--GFDLTAAQAFT 435
Query: 579 SLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAE---IREEQCAPHEPTPQGPA 635
+++F+ + L + V+S +A V+V + E I+ + +PH A
Sbjct: 436 VVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNA 495
Query: 636 --------SKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFT 687
S Q P K+ R RG ++ L + + G+
Sbjct: 496 TLAWDSSHSSIQNSPKLTPKMKKDKRAS-RGKKEKVRQLQRTEH----QAVLAEQKGHLL 550
Query: 688 WTPDGIP-------------------TLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALG 728
D P TL +I + I G+L I G VG GK+SL+ A LG
Sbjct: 551 LDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILG 610
Query: 729 EMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENII 788
+M + G++ S G AY +Q+ W+LNAT+ +NI+
Sbjct: 611 QMTLLEGSIAIS--------------------------GTFAYVAQQAWILNATLRDNIL 644
Query: 789 FESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHAN 848
F ++++RY V+ +C L+PD+ ILP D T+IGERG NLSGGQRQRIS+ARALY +
Sbjct: 645 FGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRS 704
Query: 849 VVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQ 908
+ LDDP SALD H+ +H+ + I + L+ +TV+ VTH+LQYL D +I MK+G I
Sbjct: 705 IYILDDPLSALDAHVGNHIFNSAIRKHLKS--KTVLFVTHQLQYLVDCDEVIFMKEGCIT 762
Query: 909 REGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQD 968
GT ++ + L+ + +E + +K T Q S+ + G ++
Sbjct: 763 ERGTHEELMNLNGDYATIFNNLLLGETPPVE---INSKKETSGSQKKSQDKGPKTGSVK- 818
Query: 969 EEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVA 1028
+E+A + EE + + +PW Y+ +AG L L++ + + ++ A
Sbjct: 819 ----KEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTA 874
Query: 1029 ID-YWLAKWTDSALTLTPAARNCSLSQECTLDQT----VYAMVFTVLCSLGIVLCLVTSV 1083
+WL+ W T R S ++ YA ++ + ++ ++L + V
Sbjct: 875 FSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGV 934
Query: 1084 TVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
L+ + RLH L RI+ +PM+FF+TTP G ILNRFS D + +D +P E
Sbjct: 935 VFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFI 994
Query: 1144 RSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF 1203
++ +L + +I+ V P FLVA+ PL I+ + RV R+L++LD+ TQ P LSH
Sbjct: 995 QNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHI 1054
Query: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
+++GL TI A+ F + E D N T A RWL VR++ I + LI
Sbjct: 1055 TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLIS--IALITT 1112
Query: 1264 VTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAE 1323
+ +H ++ GL ++YA+ ++ + VR ++ E + +V+RI+ +KT +
Sbjct: 1113 TGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSL 1172
Query: 1324 SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSG 1383
+ +WP +G++ +N +RY +L VLK V+ I P +KIGI GRTGSG
Sbjct: 1173 EAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSG 1232
Query: 1384 KSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER 1443
KSS +A FR+V+ G I IDG+ I+ + L LRS+LSII Q+PVLFSGT+R NLDP
Sbjct: 1233 KSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFN 1292
Query: 1444 KCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFI 1503
+ ++ +W+ALE +K + LP L++ + E G+NFS G+RQL C+ARA +R I I
Sbjct: 1293 QYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1352
Query: 1504 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPE 1563
+DEATA++D T+ ++Q+ + AFAD T++TIAHR+HT+L +D ++VL +G ++EFD P
Sbjct: 1353 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPS 1412
Query: 1564 KLLSRKDSVF-ASFVRAD 1580
LLS S F A F A+
Sbjct: 1413 VLLSNDSSRFYAMFAAAE 1430
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 643 bits (1658), Expect = 0.0
Identities = 438/1387 (31%), Positives = 704/1387 (50%), Gaps = 128/1387 (9%)
Query: 202 REVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALT 261
+EVKP LQD NL S+ +WW+N K HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 262 NYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIF 321
+ L +D +V + Q ++ +A+ + + ++ F ++ + P+ +
Sbjct: 56 LGEELQGFWDKEVLRAENDAQKP-SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 322 GIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAI 381
I+++ EN Y L AY A +L L+ +Y
Sbjct: 115 KIINYF--EN------------YDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 382 ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAM 441
G+ LR A+ IY K + LS N++MG+ T GQI NL++ D N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 442 PVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNE 501
P+Q I LL+ +G+S L G AV+I+L P+Q S + T +++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 502 MLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVG 561
++ GI+++K+YAWE F + R+KE++ + + +++ + V +TF
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 562 HVSFFKEADFSPSVAFASLSLFH-ILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR 620
+V + + S F +++L+ + +T S + +A+VS++++ FL EI
Sbjct: 339 YVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEIS 396
Query: 621 EEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQ 680
+ NR+ P+ + +V D A
Sbjct: 397 QR------------------------NRQLPSDG---------KKMVHVQDFTA------ 417
Query: 681 IMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS 740
F PTL ++ + G+L +VG VG GKSSLL A LGE+ G V
Sbjct: 418 -----FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--- 469
Query: 741 SLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKM 800
G +AY SQ+PW+ + T+ NI+F + K+RY+
Sbjct: 470 -----------------------SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEK 506
Query: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
VI+AC+L+ D+ +L GD T IG+RG LSGGQ+ R+++ARA+YQ A++ LDDP SA+D
Sbjct: 507 VIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566
Query: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
+S HL + I ++L + + +LVTH+LQYL A I+ +KDG + ++GT +F +S
Sbjct: 567 AEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG 624
Query: 921 CQLFEHWKTLMNRQDQELEKETV----TERKATEPPQGLSRAMSSR----DGLLQDEEEE 972
+ +L+ + ++E E+ V T R T + SSR DG L+ ++ E
Sbjct: 625 ID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTE 680
Query: 973 EEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYW 1032
SEE+ + + Q + +RA A ++ ++LL+ + V D+W
Sbjct: 681 NVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA------QVAYVLQDWW 734
Query: 1033 LAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
L+ W + L E LD Y +++ L ++ + S+ V + +
Sbjct: 735 LSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNS 793
Query: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1152
++ LH + I+ AP+ FF+ P+G ILNRFS D +D +P T ++ L V
Sbjct: 794 SQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGV 853
Query: 1153 LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTT 1212
++V V P + L+PL I+ F+++YF SRD+++L+ TT+ P+ SH + +++GL T
Sbjct: 854 VSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWT 913
Query: 1213 IRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLH 1272
IRA++ E R Q+ + D ++ A +RW VR++ I A V+I A S+ L
Sbjct: 914 IRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLI--LA 971
Query: 1273 RELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAES-YEGLLAP 1331
+ L AG VGL L+YAL + W VR A++E + +V+R+ E E+ +E P
Sbjct: 972 KTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRP 1031
Query: 1332 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAF 1391
P WP +G I N++ Y VLKH+ ALI +K+GI GRTG+GKSS A
Sbjct: 1032 ---PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISAL 1088
Query: 1392 FRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLW 1451
FR+ + EG I ID I ++ LH LR ++SII Q+PVLF+GT+R NLDP + +D LW
Sbjct: 1089 FRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELW 1147
Query: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
AL+ QLK ++ LPG +D + E G NFS GQRQL CLARA +RK I I+DEATA++
Sbjct: 1148 NALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANV 1207
Query: 1512 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1571
D T+ ++QK + FA TV+TIAHR++TI+ +D ++VL G + E+D+P LL K+S
Sbjct: 1208 DPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES 1267
Query: 1572 VFASFVR 1578
+F V+
Sbjct: 1268 LFYKMVQ 1274
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 633 bits (1632), Expect = 0.0
Identities = 415/1334 (31%), Positives = 675/1334 (50%), Gaps = 139/1334 (10%)
Query: 282 QGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFL 341
+GAR +W+AL AFGR + +++ +LGF+GPL + +V L +
Sbjct: 226 EGAR-LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEE------------ 272
Query: 342 GVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMH 401
QE L++ + A+ L +L Y + + RGA+ +Y K +
Sbjct: 273 ------GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQ 326
Query: 402 LSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSAL 461
L S GE NL+ D+ +L+ F W +P+Q+ + + LLY +GV+ +
Sbjct: 327 LGPSRPPTGEAL-----NLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
Query: 462 IGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTR 521
G + +LL PV +AT++ + + L++ + R+K E+L GI+++K WE R
Sbjct: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
Query: 522 VETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLS 581
VE R +E+ LR + +++ A+P+ ++ F+ +V + + + F +L+
Sbjct: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALA 499
Query: 582 LFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAV 641
L +L+ PL V+ ++A VS+ ++ FL P + Y
Sbjct: 500 LVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPN-------------HNPQAYYSP- 545
Query: 642 PLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNIT- 700
DC L ++ L+ S + +++ G F+W P G + I+
Sbjct: 546 -------------DCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISH 592
Query: 701 IRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATD 760
+ + +G L IVG+VGCGKSSLL A GE+ ++ G V L
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG--------------- 637
Query: 761 LDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQT 820
A+Q+PW+ AT+ +NI+F F+ Q YK V+EAC+L D+ ILP GDQT
Sbjct: 638 --------FGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQT 689
Query: 821 QIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDK 880
++GE+G+ LSGGQR RI++ARA+YQ + LDDP +A+D +++HL+ IL +L
Sbjct: 690 EVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTT 749
Query: 881 RTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEK 940
R +L TH+ +YL AD ++ M+ G + R G + + + W D +
Sbjct: 750 R--LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQ 807
Query: 941 ETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
K E GL S+ LLQ+E ++E A LH + W+A
Sbjct: 808 SVQNPEKTKE---GLEEEQSTSGRLLQEESKKEGAVA-----------LHVY-QAYWKAV 852
Query: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWT------DSALTLTPAARNCSL-- 1052
+ L+ A ++FS LL A D+WL+ W +S+ P+ S+
Sbjct: 853 GQGLALA-------ILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGL 905
Query: 1053 -----------------------SQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTG 1089
+ + D Y V+ + + + L+ +V
Sbjct: 906 FSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGT 965
Query: 1090 LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLC 1149
L+ A LHR LL+R+++AP+ FF TP G ILNRFSSD D +P L L +
Sbjct: 966 LQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGL 1025
Query: 1150 VSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEG 1209
+ LAV+ P L+ L PL+I+ Y +Q+++R +SR+L++L T PL SH A+T+ G
Sbjct: 1026 LGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAG 1085
Query: 1210 LTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISN 1269
L+ +RA RF+++ L + N +A +WL++R++ +GA VV +A+ I+
Sbjct: 1086 LSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVV--SAIAGIAL 1143
Query: 1270 SLHRE--LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEG 1327
H++ + GLVGL L+YAL ++ L+ +V + E L +V+R+ + +G
Sbjct: 1144 VQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG 1203
Query: 1328 LLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSF 1387
P + W QG ++ Q++ + Y L L V + PG+K+GI GRTGSGKSS
Sbjct: 1204 --QPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSL 1261
Query: 1388 SLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSD 1447
L FR+++ G +++DG+D ++L L LRS+L+II Q+P LFSGT+R NLDP+ D
Sbjct: 1262 LLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKD 1321
Query: 1448 STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEA 1507
LW+AL+ L V+ ++ GGLD + EGG + S GQRQL CLARA + I +DEA
Sbjct: 1322 RALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA 1380
Query: 1508 TASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLS 1567
TAS+D T+ +LQ+ + FA++TV+TIAHR++TIL++D V+VL+ G ++E D P L +
Sbjct: 1381 TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
Query: 1568 RKDSVFASFVRADK 1581
+ S+F +++ +
Sbjct: 1441 QPHSLFQQLLQSSQ 1454
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 610 bits (1572), Expect = e-174
Identities = 431/1391 (30%), Positives = 673/1391 (48%), Gaps = 159/1391 (11%)
Query: 226 SKGTYWWMNAFIKTAHKKPI---DLRAIGKLPIAMRALTNYQR-------LCEAFDAQVR 275
SK T+WW++ + +++P+ DL ++G+ + ++ ++ + +
Sbjct: 21 SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIA 80
Query: 276 KDIQGTQGARA----------------IWQALSHAFGRRLVLSSTFRILADLLGFAGPLC 319
+G G +A + +A+ F +L + I++D+ F P
Sbjct: 81 FKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKL 140
Query: 320 IFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYV 379
+ ++ +G PK Y+LAVL+FL+ LQ F Q + Y
Sbjct: 141 LSLFLEFIG------DPKPPAW------------KGYLLAVLMFLSACLQTLFEQQNMYR 182
Query: 380 AIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLW 439
+ LR AI +Y K++ LS+ S G + NLV++D +L LW
Sbjct: 183 LKVLQMRLRSAITGLVYRKVLALSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 240
Query: 440 AMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQT 499
V I+V + L+ +LG SAL AV + L P+ +F++ K + Q + + R + T
Sbjct: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 300
Query: 500 NEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITF 559
+ +LR K +K + WE F RV R +E+ +LR + S+S+ L+ F
Sbjct: 301 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 360
Query: 560 VGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEI 619
H + A + AF +L++ +IL L + S V+A VS +L FL E+
Sbjct: 361 AVHTLVAENA-MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 419
Query: 620 REEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCV 679
+P G + S S+ A C+
Sbjct: 420 --------DP-------------------------------GAVDS--SSSGSAAGKDCI 438
Query: 680 QIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFW 739
I F W+ + P L I + +P+G L +VG VG GKSSLL A LGE+ KV G V
Sbjct: 439 TIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV-- 496
Query: 740 SSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYK 799
G VAY Q+ W+ N +V EN+ F + +
Sbjct: 497 ------------------------SIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLE 532
Query: 800 MVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSAL 859
V+EAC+LQPD+D P G T IGE+G+NLSGGQ+QR+S+ARA+Y+ A V LDDP +AL
Sbjct: 533 RVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAAL 592
Query: 860 DIHLSDHLMQA--GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
D H+ H+ G LL+ R +LVTH L LP ADWII + +G I G+ ++
Sbjct: 593 DAHVGQHVFNQVIGPGGLLQGTTR--ILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
Query: 918 RSECQL---FEHWKTLMNRQDQELEKETVTERKATEPPQGLS---RAMSSRDGLLQDEEE 971
+ + L + + +R + E E T +T+ P+G S R R+ ++ E
Sbjct: 651 QRKGALVCLLDQARQPGDRGEGETEPGT-----STKDPRGTSAGRRPELRRERSIKSVPE 705
Query: 972 EEEEAAESEEDDNLSSMLH----------QRAEIPWRACAKYLSSAGILLLSLLVFSQLL 1021
++ +E++ + L Q + YL + G L +F L
Sbjct: 706 KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC 765
Query: 1022 KHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAM---VFTVLCSLGIVLC 1078
+ + YWL+ W D PA QT A+ +F +L L +
Sbjct: 766 QQVASFCRGYWLSLWADD-----PAVGG---------QQTQAALRGGIFGLLGCLQAIGL 811
Query: 1079 LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST 1138
+ V G + ++ L + LL ++ +P+ FFE TP+G +LNRFS + +T+D IP
Sbjct: 812 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 871
Query: 1139 LECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLP 1198
L L + V++ TP+ VA+LPL ++ Q + V+S L++L+ +
Sbjct: 872 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 931
Query: 1199 LLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACV 1258
+ SH AET +G T +RAFR +A F + D + S A+RWL +E +G +
Sbjct: 932 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 991
Query: 1259 VLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLL 1318
V AA ++ + H LSAGLVG ++ AL V+ L W+VRN D+E + +V+R+
Sbjct: 992 VFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA 1049
Query: 1319 KTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICG 1378
T E+ L + P WP G+I+ Q+ +RY L ++ V+ I G+K+GI G
Sbjct: 1050 WTPKEAPWRLPTCAAQPP-WPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVG 1108
Query: 1379 RTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFN 1438
RTG+GKSS + R+ + EG I IDG+ IA + LHTLRSR+SII QDP+LF G++R N
Sbjct: 1109 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1168
Query: 1439 LDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRK 1498
LD ++ SD +W ALE QLK +V +LPG L + GE+ S GQ+QL CLARA +RK
Sbjct: 1169 LDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRK 1228
Query: 1499 TSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILE 1558
T I I+DEATA++D TE +Q ++ + FA TV+ IAHR+ +++ V+V+ +G + E
Sbjct: 1229 TQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAE 1288
Query: 1559 FDKPEKLLSRK 1569
P +LL++K
Sbjct: 1289 SGSPAQLLAQK 1299
Score = 90.9 bits (224), Expect = 9e-18
Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 16/232 (6%)
Query: 1344 IQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1403
I IQ+ + + P L +N + G + + G G+GKSS A + EG +
Sbjct: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497
Query: 1404 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVV 1463
I+G +A +P S++ + V F LDP L LE L+ V
Sbjct: 498 IEGA-VAYVPQEAWVQNTSVV--ENVCFGQ----ELDPP------WLERVLEACALQPDV 544
Query: 1464 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMAT-ENILQKV 1522
+ P G+ I E G N S GQ+Q LARA RK +++++D+ A++D +++ +V
Sbjct: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
Query: 1523 VMTA--FADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSV 1572
+ T + + H +H + AD +IVL GAI E ++LL RK ++
Sbjct: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 656
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 608 bits (1567), Expect = e-173
Identities = 465/1596 (29%), Positives = 745/1596 (46%), Gaps = 187/1596 (11%)
Query: 26 CFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHF-PGHNLRWILTFMLLFV 84
CF+ V L++ PI + +H H +L P + +L F L+ +
Sbjct: 30 CFLRTAGVWVPPMYLWVLGPIYLLF-------IHHHGRGYLRMSPLFKAKMVLGFALIVL 82
Query: 85 LVCEIAEGI--LSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVY 142
+A + + G E+ ++ ++ ++ V+ + E + L Y
Sbjct: 83 CTSSVAVALWKIQQGTPEAPEFLIHPTV---WLTTMSFAVFLIHTERKKGVQSSGVLFGY 139
Query: 143 WTLAFITKTIKFVKFLDHAIGFSQ--LRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT 200
W L F+ + A GF +R T L + L ++ ++ + + F +
Sbjct: 140 WLLCFVLPATNAAQQASGA-GFQSDPVRHLSTYLCLSL--VVAQFVLSCLADQPPFFPED 196
Query: 201 PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI---DLRAIGKLPIAM 257
P++ P + G F SK T+WW++ + +++P+ DL ++G+ +
Sbjct: 197 PQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
Query: 258 RALTNYQR-------LCEAFDAQVRKDIQGTQGARA----------------IWQALSHA 294
++ ++ + + +G G +A + +A+
Sbjct: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV 306
Query: 295 FGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLAN 354
F +L + I++D+ F P + ++ +G PK
Sbjct: 307 FHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIG------DPKPPAW------------K 348
Query: 355 AYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTA 414
Y+LAVL+FL+ LQ F Q + Y + LR AI +Y K++ LS+ S
Sbjct: 349 GYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSG--SRKASAV 406
Query: 415 GQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQ 474
G + NLV++D +L LW V I+V + L+ +LG SAL AV + L P+
Sbjct: 407 GDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLN 466
Query: 475 YFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLR 534
+F++ K + Q + + R + T+ +LR K +K + WE F RV R +E+ +LR
Sbjct: 467 FFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALR 526
Query: 535 AFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLS 594
+ S+S+ L+ F H + A + AF +L++ +IL L
Sbjct: 527 TSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA-MNAEKAFVTLTVLNILNKAQAFLP 585
Query: 595 SVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPARE 654
+ S V+A VS +L FL E+ +P
Sbjct: 586 FSIHSLVQARVSFDRLVTFLCLEEV--------DP------------------------- 612
Query: 655 DCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
G + S S+ A C+ I F W+ + P L I + +P+G L +VG
Sbjct: 613 ------GVVDS--SSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGP 664
Query: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
VG GKSSLL A LGE+ KV G V G VAY Q
Sbjct: 665 VGAGKSSLLSALLGELSKVEGFV--------------------------SIEGAVAYVPQ 698
Query: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
+ W+ N +V EN+ F + + V+EAC+LQPD+D P G T IGE+G+NLSGGQ+
Sbjct: 699 EAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQK 758
Query: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA--GILELLRDDKRTVVLVTHKLQY 892
QR+S+ARA+Y+ A V LDDP +ALD H+ H+ G LL+ R +LVTH L
Sbjct: 759 QRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTR--ILVTHALHI 816
Query: 893 LPHADWIIAMKDGTIQREGTLKDFQRSECQL---FEHWKTLMNRQDQELEKETVTERKAT 949
LP ADWII + +G I G+ ++ + + L + + +R + E E T +T
Sbjct: 817 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGT-----ST 871
Query: 950 EPPQGLS---RAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLH----------QRAEIP 996
+ P+G S R R+ ++ E++ +E++ + L Q +
Sbjct: 872 KDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVK 931
Query: 997 WRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQEC 1056
YL + G L +F L + + YWL+ W D PA
Sbjct: 932 ATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADD-----PAVGG------- 979
Query: 1057 TLDQTVYAM---VFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFE 1113
QT A+ +F +L L + + V G + ++ L + LL ++ +P+ FFE
Sbjct: 980 --QQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE 1037
Query: 1114 TTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIV 1173
TP+G +LNRFS + +T+D IP L L + V++ TP+ VA+LPL ++
Sbjct: 1038 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 1097
Query: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Q + V+S L++L+ + + SH AET +G T +RAFR +A F + D +
Sbjct: 1098 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDES 1157
Query: 1234 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY 1293
S A+RWL +E +G +V AA ++ + H LSAGLVG ++ AL V+
Sbjct: 1158 QRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQT 1215
Query: 1294 LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY 1353
L W+VRN D+E + +V+R+ T E+ L + P WP G+I+ ++ +RY
Sbjct: 1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP-WPQGGQIEFRDFGLRY 1274
Query: 1354 DSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLP 1413
L ++ V+ I G+K+GI GRTG+GKSS + R+ + EG I IDG+ IA +
Sbjct: 1275 RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVG 1334
Query: 1414 LHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAI 1473
LHTLRSR+SII QDP+LF G++R NLD ++ SD +W ALE QLK +V +LPG L
Sbjct: 1335 LHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYK 1394
Query: 1474 ITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVV 1533
+ GE+ S GQ+QL CLARA +RKT I I+DEATA++D TE +Q ++ + FA TV+
Sbjct: 1395 CADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVL 1454
Query: 1534 TIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
IAHR+ +++ V+V+ +G + E P +LL++K
Sbjct: 1455 LIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1490
Score = 89.0 bits (219), Expect = 3e-17
Identities = 66/232 (28%), Positives = 108/232 (46%), Gaps = 16/232 (6%)
Query: 1344 IQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1403
I I + + + P L +N + G + + G G+GKSS A + EG +
Sbjct: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688
Query: 1404 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVV 1463
I+G +A +P S++ + V F LDP L LE L+ V
Sbjct: 689 IEGA-VAYVPQEAWVQNTSVV--ENVCFGQ----ELDPP------WLERVLEACALQPDV 735
Query: 1464 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMAT-ENILQKV 1522
+ P G+ I E G N S GQ+Q LARA RK +++++D+ A++D +++ +V
Sbjct: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
Query: 1523 VMTA--FADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSV 1572
+ T + + H +H + AD +IVL GAI E ++LL RK ++
Sbjct: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 847
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 595 bits (1535), Expect = e-170
Identities = 407/1389 (29%), Positives = 687/1389 (49%), Gaps = 115/1389 (8%)
Query: 224 LLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQG 283
LLS T+ W+ + +++ + + + L + TN +R +D +V + G +
Sbjct: 51 LLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR--VGPEK 108
Query: 284 ARAIWQALSHAFGR----RLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQ 339
A +LSH + R+++ IL ++ GP+ + + + Q +
Sbjct: 109 A-----SLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILI---------HQILQQTER 154
Query: 340 FLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKI 399
G +V L + LF + F ++ + T I L+ A+ T ++ +
Sbjct: 155 TSGKVWVGIG--------LCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL 206
Query: 400 MHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVS 459
+ T + ++ G++ N+++ D+ L CP +P+ ++ ++ILG +
Sbjct: 207 VSFKT----LTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
Query: 460 ALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFR 519
ALIG +V ++ PVQ F+A S +RS + +++R++ NE L I+L+K+YAWE F
Sbjct: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
Query: 520 TRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFAS 579
++ RR+E L S + + + A+++T H+ ++ + VAF+
Sbjct: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK--LTAPVAFSV 380
Query: 580 LSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEP---------- 629
+++F+++ + +L +++ +A VS++++ + L P +P
Sbjct: 381 IAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANAT 440
Query: 630 -TPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTW 688
T + AS+ ++ P ++ N+KR + R +S P A G G
Sbjct: 441 LTWEHEASR-KSTPKKLQNQKRHLCKKQRSEAYSERS--PPAKGAT---------GPEEQ 488
Query: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
+ L +I+ + +G++ I G VG GKSSLL A LG+MQ G V
Sbjct: 489 SDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVV----------- 537
Query: 749 EDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQ 808
G +AY SQ+ W+ + V ENI+F ++ QRY+ + C LQ
Sbjct: 538 ---------------AVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQ 582
Query: 809 PDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLM 868
D+ LP+GD T+IGERG+NLSGGQRQRIS+ARA+Y + LDDP SA+D H+ H+
Sbjct: 583 KDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVF 642
Query: 869 QAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQLFE 925
+ I + LR +TVVLVTH+LQ+L D +I ++DG I +GT K+ +L
Sbjct: 643 EECIKKTLRG--KTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH 700
Query: 926 HWKTLMNRQDQELEKETVTERKATEPPQGLSRA--MSSRDGLLQDEEEEEEEAAES---- 979
+ + L + + L + E P + A + G +DE +E E +E
Sbjct: 701 NLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTK 760
Query: 980 -EEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLL-VFSQLLKHMVLVAIDYWLAKWT 1037
E + + Q + W+ Y+ ++G LLSL VF LL ++WL W
Sbjct: 761 VPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWL 820
Query: 1038 D--SALTLTPAARNCSLSQECTL---DQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
D S +T P L Q VY V+T +V + T L
Sbjct: 821 DKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMA 880
Query: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1152
+ LH ++ ++I+ +PM FF+TTP G ++NRFS D + +D +P E + + V
Sbjct: 881 SSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFI 940
Query: 1153 LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTT 1212
L +++ V P L+ + LA+ + + + F ++L+++++ ++ P +H +++GL
Sbjct: 941 LVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGI 1000
Query: 1213 IRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYI-GACVVLIAAVTSISNSL 1271
I A+ + + + Y L+ A RW +RM+ + +A + ++S S
Sbjct: 1001 IHAYGKK----ESCITYH------LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFS- 1049
Query: 1272 HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAP 1331
+S GL L+Y + +S L VR + + + +V+ + + T L
Sbjct: 1050 --SISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
Query: 1332 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAF 1391
PK+WP +G+I ++ +RY + VL +N I GQ +GI GRTGSGKSS +A
Sbjct: 1108 GTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMAL 1167
Query: 1392 FRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLW 1451
FR+V+ G I ID +DI L L LR++L++I QDPVLF GT+R+NLDP +D LW
Sbjct: 1168 FRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLW 1227
Query: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
+ LE ++ + LP L A +TE GENFS G+RQL C+ARA +R + I ++DEATAS+
Sbjct: 1228 QVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASM 1287
Query: 1512 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1571
D T+ ++Q + AF TV+TIAHR++T+L+ D V+V++ G ++EFDKPE L + DS
Sbjct: 1288 DSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDS 1347
Query: 1572 VFASFVRAD 1580
FA + A+
Sbjct: 1348 AFAMLLAAE 1356
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 565 bits (1456), Expect = e-160
Identities = 399/1415 (28%), Positives = 673/1415 (47%), Gaps = 134/1415 (9%)
Query: 202 REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247
R PP D +R + PF L S T W+ + + + +D
Sbjct: 55 RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114
Query: 248 RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306
I L + + N QRL ++ +V + +G + A + L F R RL+ +
Sbjct: 115 NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170
Query: 307 ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366
I + GP+ I + +E LG + + L LFL+
Sbjct: 171 ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213
Query: 367 LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426
++ +S+ + T I R A+ + + K++ S+ +T+G+ + D N
Sbjct: 214 CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269
Query: 427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486
L P + +++ I Y+I+G +A I +L+ P+ F+ +AQ
Sbjct: 270 YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329
Query: 487 STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546
T E S++R++ T+E+L IKL+K+Y WE F +E RRKE L + S++
Sbjct: 330 HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389
Query: 547 NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606
IP A + + H S + + S+AF+ L+ ++L +F + V+ + +
Sbjct: 390 LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447
Query: 607 VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655
V + +F +E + T Q P+ +Q +VN +
Sbjct: 448 VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502
Query: 656 -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
G+T P +L P +G++ +G P L I + + +G + + G
Sbjct: 503 ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545
Query: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
G GKSSLL A L EM + G+V +G +AY Q
Sbjct: 546 TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579
Query: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
+ W+++ + ENI+ ++K RY V+ CSL D+++LP GD T+IGERG+NLSGGQ+
Sbjct: 580 QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639
Query: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894
QRIS+ARA+Y + LDDP SA+D H+ H+ + I + LR +TVVLVTH+LQYL
Sbjct: 640 QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697
Query: 895 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954
II +++G I GT + + + + + + + ++ ++T K E P+
Sbjct: 698 FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754
Query: 955 LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013
S+A++ S + L E + + EE + + WR Y+ +AG ++S
Sbjct: 755 ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806
Query: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063
++F ++ + L +W L+ W + + N + + + + Q VY
Sbjct: 807 CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866
Query: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
+ +L +G+ + T VT K + LH L N++ PM FF+T P+G +LN
Sbjct: 867 GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
F+ D +DQ +P E +L+ ++ L ++S ++P L+ + ++C+ F+
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
A ++L++ ++ PL SH +++GL++I + F + TD+ N L +
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302
+ RW+ +R+E + V L A+ S ++ + + L +++ R
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099
Query: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362
+ E Q AV+RI +K + + P+ WP G+I Q+ ++Y + VL
Sbjct: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159
Query: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422
+N I + +GI GRTGSGKSS +A FR+V+ G I+IDG+DI + L LRS+LS
Sbjct: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219
Query: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
+I QDPVL SGTIRFNLDP + +D +W+ALE L + P L + E G NFS
Sbjct: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFS 1279
Query: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
G+RQL C+ARA +R + I ++DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+
Sbjct: 1280 VGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1339
Query: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
L+ D ++V+ G ++EFD+PE L + S+FA+ +
Sbjct: 1340 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1374
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 565 bits (1456), Expect = e-160
Identities = 399/1415 (28%), Positives = 673/1415 (47%), Gaps = 134/1415 (9%)
Query: 202 REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247
R PP D +R + PF L S T W+ + + + +D
Sbjct: 55 RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114
Query: 248 RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306
I L + + N QRL ++ +V + +G + A + L F R RL+ +
Sbjct: 115 NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170
Query: 307 ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366
I + GP+ I + +E LG + + L LFL+
Sbjct: 171 ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213
Query: 367 LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426
++ +S+ + T I R A+ + + K++ S+ +T+G+ + D N
Sbjct: 214 CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269
Query: 427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486
L P + +++ I Y+I+G +A I +L+ P+ F+ +AQ
Sbjct: 270 YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329
Query: 487 STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546
T E S++R++ T+E+L IKL+K+Y WE F +E RRKE L + S++
Sbjct: 330 HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389
Query: 547 NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606
IP A + + H S + + S+AF+ L+ ++L +F + V+ + +
Sbjct: 390 LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447
Query: 607 VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655
V + +F +E + T Q P+ +Q +VN +
Sbjct: 448 VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502
Query: 656 -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
G+T P +L P +G++ +G P L I + + +G + + G
Sbjct: 503 ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545
Query: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
G GKSSLL A L EM + G+V +G +AY Q
Sbjct: 546 TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579
Query: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
+ W+++ + ENI+ ++K RY V+ CSL D+++LP GD T+IGERG+NLSGGQ+
Sbjct: 580 QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639
Query: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894
QRIS+ARA+Y + LDDP SA+D H+ H+ + I + LR +TVVLVTH+LQYL
Sbjct: 640 QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697
Query: 895 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954
II +++G I GT + + + + + + + ++ ++T K E P+
Sbjct: 698 FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754
Query: 955 LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013
S+A++ S + L E + + EE + + WR Y+ +AG ++S
Sbjct: 755 ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806
Query: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063
++F ++ + L +W L+ W + + N + + + + Q VY
Sbjct: 807 CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866
Query: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
+ +L +G+ + T VT K + LH L N++ PM FF+T P+G +LN
Sbjct: 867 GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
F+ D +DQ +P E +L+ ++ L ++S ++P L+ + ++C+ F+
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
A ++L++ ++ PL SH +++GL++I + F + TD+ N L +
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302
+ RW+ +R+E + V L A+ S ++ + + L +++ R
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099
Query: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362
+ E Q AV+RI +K + + P+ WP G+I Q+ ++Y + VL
Sbjct: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159
Query: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422
+N I + +GI GRTGSGKSS +A FR+V+ G I+IDG+DI + L LRS+LS
Sbjct: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219
Query: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
+I QDPVL SGTIRFNLDP + +D +W+ALE L + P L + E G NFS
Sbjct: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFS 1279
Query: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
G+RQL C+ARA +R + I ++DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+
Sbjct: 1280 VGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1339
Query: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
L+ D ++V+ G ++EFD+PE L + S+FA+ +
Sbjct: 1340 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1374
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 518 bits (1335), Expect = e-146
Identities = 385/1415 (27%), Positives = 655/1415 (46%), Gaps = 172/1415 (12%)
Query: 202 REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247
R PP D +R + PF L S T W+ + + + +D
Sbjct: 55 RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114
Query: 248 RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306
I L + + N QRL ++ +V + +G + A + L F R RL+ +
Sbjct: 115 NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170
Query: 307 ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366
I + GP+ I + +E LG + + L LFL+
Sbjct: 171 ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213
Query: 367 LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426
++ +S+ + T I R A+ + + K++ S+ +T+G+ + D N
Sbjct: 214 CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269
Query: 427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486
L P + +++ I Y+I+G +A I +L+ P+ F+ +AQ
Sbjct: 270 YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329
Query: 487 STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546
T E S++R++ T+E+L IKL+K+Y WE F +E RRKE L + S++
Sbjct: 330 HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389
Query: 547 NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606
IP A + + H S + + S+AF+ L+ ++L +F + V+ + +
Sbjct: 390 LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447
Query: 607 VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655
V + +F +E + T Q P+ +Q +VN +
Sbjct: 448 VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502
Query: 656 -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
G+T P +L P +G++ +G P L I + + +G + + G
Sbjct: 503 ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545
Query: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
G GKSSLL A L EM + G+V +G +AY Q
Sbjct: 546 TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579
Query: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
+ W+++ + ENI+ ++K RY V+ CSL D+++LP GD T+IGERG+NLSGGQ+
Sbjct: 580 QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639
Query: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894
QRIS+ARA+Y + LDDP SA+D H+ H+ + I + LR +TVVLVTH+LQYL
Sbjct: 640 QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697
Query: 895 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954
II +++G I GT + + + + + + + ++ ++T K E P+
Sbjct: 698 FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754
Query: 955 LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013
S+A++ S + L E + + EE + + WR Y+ +AG ++S
Sbjct: 755 ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806
Query: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063
++F ++ + L +W L+ W + + N + + + + Q VY
Sbjct: 807 CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866
Query: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
+ +L +G+ + T VT K + LH L N++ PM FF+T P+G +LN
Sbjct: 867 GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
F+ D +DQ +P E +L+ ++ L ++S ++P L+ + ++C+ F+
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
A ++L++ ++ PL SH +++GL++I + F + TD+ N L +
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302
+ RW+ +R+E + V L A+ S ++ + + L +++ R
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099
Query: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362
+ E Q AV+RI +K + + P+ WP G+I Q+ ++Y + VL
Sbjct: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159
Query: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422
+N I + +GI GRTGSGKSS +A FR+V+ G I+IDG+DI + L LRS+LS
Sbjct: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219
Query: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
+I QDPVL SGTIRFNLDP + +D +W+ALE
Sbjct: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--------------------------- 1252
Query: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
R F+ K +I ++DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+
Sbjct: 1253 ----------RTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1301
Query: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
L+ D ++V+ G ++EFD+PE L + S+FA+ +
Sbjct: 1302 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 507 bits (1305), Expect = e-143
Identities = 292/772 (37%), Positives = 449/772 (58%), Gaps = 44/772 (5%)
Query: 825 RGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVV 884
+G+NLSGGQ+QR+S+ARA+Y +A++ DDP SA+D H+ H+ + I +T +
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
Query: 885 LVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETV 943
LVTH + YLP D II M G I G+ ++ + E +T + Q+Q+ E+ V
Sbjct: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 824
Query: 944 TE-----RKATEPPQG----------LSRAMSSRDGLLQD--------EEEEEEEAAESE 980
T ++A + G L R +SS D E ++ EA + E
Sbjct: 825 TGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEE 884
Query: 981 EDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSA 1040
+ + Q ++ Y+ + G+ + L +F + H+ +A +YWL+ WTD
Sbjct: 885 TWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP 944
Query: 1041 LTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLH 1097
+ + +QE T + +V +LGI + S+ V G+ ++ LH
Sbjct: 945 IV--------NGTQEHT------KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLH 990
Query: 1098 RSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVIS 1157
LL+ I+ +PM FFE TP G+++NRFS + +T+D IP ++ S + A VI
Sbjct: 991 VDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
Query: 1158 YVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFR 1217
TP+ + + PL ++ +F+Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF
Sbjct: 1051 LATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFE 1110
Query: 1218 YEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSA 1277
+ RF + D N A ANRWL VR+E +G C+VL AA+ ++ + LSA
Sbjct: 1111 EQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSA 1168
Query: 1278 GLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKN 1337
GLVGL ++Y+L V+ YLNW+VR ++ME + AV+R+ +TE E+ + + P +
Sbjct: 1169 GLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSS 1227
Query: 1338 WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDT 1397
WP G+++ +N +RY L VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++
Sbjct: 1228 WPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINES 1287
Query: 1398 FEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIA 1457
EG IIIDGI+IAK+ LH LR +++II QDPVLFSG++R NLDP + SD +W +LE+A
Sbjct: 1288 AEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELA 1347
Query: 1458 QLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATEN 1517
LK V ALP LD EGGEN S GQRQL CLARA +RKT I ++DEATA++D+ T++
Sbjct: 1348 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1407
Query: 1518 ILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
++Q + T F D TV+TIAHR++TI+ VIVL +G I E+ P LL ++
Sbjct: 1408 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1459
Score = 211 bits (538), Expect = 3e-54
Identities = 154/553 (27%), Positives = 253/553 (45%), Gaps = 102/553 (18%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
Query: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Q K + ++ ++++ L FG ++S
Sbjct: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Query: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
Query: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
Query: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
Query: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
VS+++L FLS E+ + +RP +
Sbjct: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
Query: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 637 ------DGGGTN-SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 725 AALGEMQKVSGAV 737
A L EM KV G V
Sbjct: 690 ALLAEMDKVEGHV 702
Score = 74.7 bits (182), Expect = 7e-13
Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%)
Query: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
L +I + I G+ IVG+ G GKSSL L + G + + ++IG
Sbjct: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH----- 1305
Query: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILP 815
D+R + + Q P L + ++ N+ S ++ + +E L+ + LP
Sbjct: 1306 ------DLRFK--ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALP 1357
Query: 816 HGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILEL 875
+ E G NLS GQRQ + +ARAL + ++ LD+ +A+D+ +D L+Q+ I
Sbjct: 1358 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQ 1416
Query: 876 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKD 915
D TV+ + H+L + +I + G IQ G D
Sbjct: 1417 FED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSD 1454
Score = 54.7 bits (130), Expect = 7e-07
Identities = 77/364 (21%), Positives = 154/364 (42%), Gaps = 39/364 (10%)
Query: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
Query: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
Query: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
Query: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I G
Sbjct: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
Query: 1407 IDIA 1410
++++
Sbjct: 707 VNLS 710
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 458 bits (1179), Expect = e-128
Identities = 268/716 (37%), Positives = 412/716 (57%), Gaps = 44/716 (6%)
Query: 881 RTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELE 939
+T +LVTH + YLP D II M G I G+ ++ + E +T + Q+Q+ E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 940 KETVTE-----RKATEPPQG----------LSRAMSSRDGLLQD--------EEEEEEEA 976
+ VT ++A + G L R +SS D E ++ EA
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 977 AESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKW 1036
+ E + + Q ++ Y+ + G+ + L +F + H+ +A +YWL+ W
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
Query: 1037 TDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVA 1093
TD + + +QE T + +V +LGI + S+ V G+ +
Sbjct: 885 TDDPIV--------NGTQEHT------KVRLSVYGALGISQGIAVFGYSMAVSIGGILAS 930
Query: 1094 KRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSAL 1153
+ LH LL+ I+ +PM FFE TP G+++NRFS + +T+D IP ++ S + A
Sbjct: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGAC 990
Query: 1154 AVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1213
VI TP+ + + PL ++ +F+Q+++ +SR L++L+ ++ P+ SHF ET+ G++ I
Sbjct: 991 IVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
Query: 1214 RAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHR 1273
RAF + RF + D N A ANRWL VR+E +G C+VL AA+ ++ +
Sbjct: 1051 RAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RH 1108
Query: 1274 ELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSL 1333
LSAGLVGL ++Y+L V+ YLNW+VR ++ME + AV+R+ +TE E+ + +
Sbjct: 1109 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETA 1167
Query: 1334 IPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFR 1393
P +WP G+++ +N +RY L VL+H+N I G+K+GI GRTG+GKSS +L FR
Sbjct: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
Query: 1394 MVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEA 1453
+ ++ EG IIIDGI+IAK+ LH LR +++II QDPVLFSG++R NLDP + SD +W +
Sbjct: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
Query: 1454 LEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM 1513
LE+A LK V ALP LD EGGEN S GQRQL CLARA +RKT I ++DEATA++D+
Sbjct: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
Query: 1514 ATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
T++++Q + T F D TV+TIAHR++TI+ VIVL +G I E+ P LL ++
Sbjct: 1348 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
Score = 211 bits (538), Expect = 3e-54
Identities = 154/553 (27%), Positives = 253/553 (45%), Gaps = 102/553 (18%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
Query: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Q K + ++ ++++ L FG ++S
Sbjct: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Query: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
Query: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
Query: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
Query: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
VS+++L FLS E+ + +RP +
Sbjct: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
Query: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 637 ------DGGGTN-SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 725 AALGEMQKVSGAV 737
A L EM KV G V
Sbjct: 690 ALLAEMDKVEGHV 702
Score = 74.7 bits (182), Expect = 7e-13
Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%)
Query: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
L +I + I G+ IVG+ G GKSSL L + G + + ++IG
Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH----- 1249
Query: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILP 815
D+R + + Q P L + ++ N+ S ++ + +E L+ + LP
Sbjct: 1250 ------DLRFK--ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALP 1301
Query: 816 HGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILEL 875
+ E G NLS GQRQ + +ARAL + ++ LD+ +A+D+ +D L+Q+ I
Sbjct: 1302 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQ 1360
Query: 876 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKD 915
D TV+ + H+L + +I + G IQ G D
Sbjct: 1361 FED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSD 1398
Score = 50.1 bits (118), Expect = 2e-05
Identities = 76/358 (21%), Positives = 149/358 (41%), Gaps = 39/358 (10%)
Query: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Query: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
Query: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
Query: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
Query: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
Query: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIII 1404
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I
Sbjct: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 32.7 bits (73), Expect = 2.9
Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1528 ADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
A +T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 703 AIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 752
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 332 bits (852), Expect = 1e-90
Identities = 262/962 (27%), Positives = 445/962 (46%), Gaps = 122/962 (12%)
Query: 202 REVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALT 261
+EVKP LQD NL S+ +WW+N K HK+ ++ + + R+
Sbjct: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Query: 262 NYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIF 321
+ L +D +V + Q ++ +A+ + + ++ F ++ + P+ +
Sbjct: 56 LGEELQGFWDKEVLRAENDAQKP-SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
Query: 322 GIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAI 381
I+++ EN Y L AY A +L L+ +Y
Sbjct: 115 KIINYF--EN------------YDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 382 ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAM 441
G+ LR A+ IY K + LS N++MG+ T GQI NL++ D N+ LWA
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
Query: 442 PVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNE 501
P+Q I LL+ +G+S L G AV+I+L P+Q S + T +++ R++ NE
Sbjct: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
Query: 502 MLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVG 561
++ GI+++K+YAWE F + R+KE++ + + +++ + V +TF
Sbjct: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
Query: 562 HVSFFKEADFSPSVAFASLSLFH-ILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR 620
+V + + S F +++L+ + +T S + +A+VS++++ FL EI
Sbjct: 339 YVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEIS 396
Query: 621 EEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQ 680
+ NR+ P+ + +V D A
Sbjct: 397 QR------------------------NRQLPSDG---------KKMVHVQDFTA------ 417
Query: 681 IMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS 740
F PTL ++ + G+L +VG VG GKSSLL A LGE+ G V
Sbjct: 418 -----FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--- 469
Query: 741 SLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKM 800
G +AY SQ+PW+ + T+ NI+F + K+RY+
Sbjct: 470 -----------------------SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEK 506
Query: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
VI+AC+L+ D+ +L GD T IG+RG LSGGQ+ R+++ARA+YQ A++ LDDP SA+D
Sbjct: 507 VIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566
Query: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
+S HL + I ++L + + +LVTH+LQYL A I+ +KDG + ++GT +F +S
Sbjct: 567 AEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG 624
Query: 921 CQLFEHWKTLMNRQDQELEKE----TVTERKATEPPQGLSRAMSSR----DGLLQDEEEE 972
+ +L+ + ++E E+ T T R T + SSR DG L+ ++ E
Sbjct: 625 ID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTE 680
Query: 973 EEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYW 1032
SEE+ + + Q + +RA A ++ ++LL+ + V D+W
Sbjct: 681 NVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA------QVAYVLQDWW 734
Query: 1033 LAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
L+ W + L E LD Y +++ L ++ + S+ V + +
Sbjct: 735 LSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNS 793
Query: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVS 1151
++ LH + I+ AP+ FF+ P+G ILNRFS D +D +P T L+ + R L +S
Sbjct: 794 SQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLS 853
Query: 1152 AL 1153
L
Sbjct: 854 WL 855
Score = 93.2 bits (230), Expect = 2e-18
Identities = 95/504 (18%), Positives = 214/504 (42%), Gaps = 35/504 (6%)
Query: 1063 YAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
YA V T + +L + V+ G+++ + + + + T G I+N
Sbjct: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
Query: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
S+D N DQ + L L L ++ A++ + +A + + I+ +Q F
Sbjct: 197 LLSNDVNKFDQ-VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG 255
Query: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
L+ T + E + G+ I+ + +E F L+ I+ + ++
Sbjct: 256 KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSN-LITNLRKKEISKILRSS 314
Query: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY----ALMVSNYLNWMV 1298
R + + + + +++ T+ L ++A V + +T L V+ + +
Sbjct: 315 CLRGMNLASFFSASKIIVFVTFTTYV-LLGSVITASRVFVAVTLYGAVRLTVTLFFPSAI 373
Query: 1299 RNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGK--IQIQNLSVRYD-S 1355
+++ + +++RI L + S + P GK + +Q+ + +D +
Sbjct: 374 ERVSEA---IVSIRRIQTFLLLDEISQRN--------RQLPSDGKKMVHVQDFTAFWDKA 422
Query: 1356 SLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLH 1415
S P L+ ++ + PG+ + + G G+GKSS A + G + + G
Sbjct: 423 SETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG--------- 473
Query: 1416 TLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIIT 1475
R++ + Q P +FSGT+R N+ +K + ++ LK ++ L G +I
Sbjct: 474 ----RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIG 529
Query: 1476 EGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATENILQKVVMTAFADRTVVT 1534
+ G S GQ+ LARA + I+++D+ +++D + ++ + + ++ +
Sbjct: 530 DRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITIL 589
Query: 1535 IAHRVHTILSADLVIVLKRGAILE 1558
+ H++ + +A +++LK G +++
Sbjct: 590 VTHQLQYLKAASQILILKDGKMVQ 613
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 285 bits (728), Expect = 3e-76
Identities = 191/660 (28%), Positives = 326/660 (49%), Gaps = 41/660 (6%)
Query: 940 KETVTERKATEPPQG-------LSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQR 992
K T + RK + PQ SR +S GL EE EE+ E DD M
Sbjct: 786 KTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD----MESIP 841
Query: 993 AEIPWRACAKYL----SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTD-SALTLTPAA 1047
A W +Y+ S +L+ L++F L + + WL T + +
Sbjct: 842 AVTTWNTYLRYITVHKSLIFVLIWCLVIF---LAEVAASLVVLWLLGNTPLQDKGNSTHS 898
Query: 1048 RNCSLSQECTLDQTVYAM-VFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIIL 1106
RN S + T + Y ++ + + + + + T + V+K LH +L+ ++
Sbjct: 899 RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
Query: 1107 APMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVA 1166
APM T G ILNRFS D +D +P T+ + L+ + A+AV++ + P VA
Sbjct: 959 APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
Query: 1167 LLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKL 1226
+P+ + ++ YF S+ L+QL+ + P+ +H +++GL T+RAF + F+
Sbjct: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
Query: 1227 LEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY 1286
+ + + + RW ++R+E I V+ AVT IS E G VG+ LT
Sbjct: 1079 HKALNLHTANWFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGE-GEGRVGIILTL 1135
Query: 1287 ALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESY---------EGLLAPSLIPKN 1337
A+ + + L W V + D++ + +V R+ + E G L+ +I +N
Sbjct: 1136 AMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIEN 1195
Query: 1338 --------WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSL 1389
WP G++ +++L+ +Y +L++++ I+PGQ++G+ GRTGSGKS+
Sbjct: 1196 SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLS 1255
Query: 1390 AFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDST 1449
AF R+++T EG I IDG+ + L R +I Q +FSGT R NLDP + SD
Sbjct: 1256 AFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQE 1314
Query: 1450 LWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATA 1509
+W+ + L+ V++ PG LD ++ +GG S G +QL CLAR+ + K I ++DE +A
Sbjct: 1315 IWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSA 1374
Query: 1510 SIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
+D T I+++ + AFAD TV+ HR+ +L +V++ + ++D +KLL+ +
Sbjct: 1375 HLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER 1434
Score = 197 bits (500), Expect = 9e-50
Identities = 167/698 (23%), Positives = 314/698 (44%), Gaps = 76/698 (10%)
Query: 223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQ 282
+++SK + W ++ +++ ++L I ++P ++ + L E + + +++ +
Sbjct: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
Query: 283 GARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLG 342
+ I AL F R + F L ++ PL + I+ +N
Sbjct: 66 NPKLI-NALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDN----------- 113
Query: 343 VYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHL 402
+E + A L + L L +++ L + + G+ +R A+ + IY K + L
Sbjct: 114 ------KEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKL 167
Query: 403 STSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALI 462
S+ L +++ GQ+ +L++ + N+ L +W P+Q+ + + L++ +L SA
Sbjct: 168 SSRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC 225
Query: 463 GAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRV 522
G +I+LA Q + + + + +ERL T+EM+ I+ +K Y WE +
Sbjct: 226 GLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
Query: 523 ETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSL 582
E R+ E+ R A + F ++A + + F+ + + F ++S
Sbjct: 286 ENLRQTELKLTRKAAY---VRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISF 342
Query: 583 FHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQ 639
+L VT F + V++ +L ++ K+ +FL E + +Y
Sbjct: 343 CIVLRMAVTRQFPWA--VQTWYDSLGAINKIQDFLQKQEYK--------------TLEYN 386
Query: 640 AVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNI 699
VV A + G G L + + + ++ G P L +I
Sbjct: 387 LTTTEVVMENVTAFWE-EGF-GELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDI 444
Query: 700 TIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETAT 759
+I RGQL + G G GK+SLL+ +GE++ G
Sbjct: 445 NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGK----------------------- 481
Query: 760 DLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQ 819
I+ G +++ SQ W++ T++ENIIF +++ RY+ VI+AC L+ DI D
Sbjct: 482 ---IKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDN 538
Query: 820 TQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDD 879
+GE GI LSGGQR RIS+ARA+Y+ A++ LD PF LD+ + ++ + +L+ +
Sbjct: 539 IVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN- 597
Query: 880 KRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
+T +LVT K+++L AD I+ + +G+ GT + Q
Sbjct: 598 -KTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQ 634
Score = 72.8 bits (177), Expect = 2e-12
Identities = 84/380 (22%), Positives = 159/380 (41%), Gaps = 47/380 (12%)
Query: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
+E +E + +++A+ +E + K++E + A R+ + V+ +
Sbjct: 263 SEMIENIQSVKAYCWEEAME-KMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS 321
Query: 1264 VTS---ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLL-K 1319
V I + R++ + + + V+ W V+ D LGA+ +I L K
Sbjct: 322 VLPYALIKGIILRKIFT-TISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQK 377
Query: 1320 TEAESYE-GLLAPSLIPKN----WPDQGKIQI-----QNLSVRY----DSSL-------- 1357
E ++ E L ++ +N W ++G ++ QN + R D SL
Sbjct: 378 QEYKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL 436
Query: 1358 -KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHT 1416
PVLK +N I GQ + + G TG+GK+S + ++ EG I G
Sbjct: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG---------- 486
Query: 1417 LRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITE 1476
R+S Q + GTI+ N+ + ++ QL+ + + ++ E
Sbjct: 487 ---RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGE 543
Query: 1477 GGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE-NILQKVVMTAFADRTVVTI 1535
GG S GQR LARA + ++++D +D+ TE I + V A++T + +
Sbjct: 544 GGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILV 603
Query: 1536 AHRVHTILSADLVIVLKRGA 1555
++ + AD +++L G+
Sbjct: 604 TSKMEHLKKADKILILHEGS 623
Score = 55.5 bits (132), Expect = 4e-07
Identities = 63/293 (21%), Positives = 124/293 (42%), Gaps = 43/293 (14%)
Query: 688 WTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAAL------GEMQKVSGAVFWSS 741
+T G L NI+ I GQ ++G+ G GKS+LL A L GE+Q + G V W S
Sbjct: 1219 YTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQ-IDG-VSWDS 1276
Query: 742 LPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMV 801
+ + R QK ++ + T +N+ ++ Q V
Sbjct: 1277 ITLQQ------------------WRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
Query: 802 IEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDI 861
+ L+ I+ P + + G LS G +Q + +AR++ A ++ LD+P + LD
Sbjct: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD- 1377
Query: 862 HLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC 921
++ +++ + + D TV+L H+++ + + +++ +++
Sbjct: 1378 PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ------------ 1423
Query: 922 QLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEE 974
++ + L+N + + + ++R P + S+ S EE EEE
Sbjct: 1424 --YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 218 bits (554), Expect = 5e-56
Identities = 204/911 (22%), Positives = 395/911 (43%), Gaps = 77/911 (8%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
+ L + +++ GQ +VG GCGKS+ + MQ++ DP+
Sbjct: 407 VKILKGLNLKVQSGQTVALVGNSGCGKSTTVQL----MQRLY---------------DPT 447
Query: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
+ DIR R + SQ+P L T+ ENI + + ++
Sbjct: 448 EGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 507
Query: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
+ I LPH T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD S+
Sbjct: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SE 566
Query: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
++Q + + + RT +++ H+L + +AD I DG I +G + + + F+
Sbjct: 567 AVVQVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFK 624
Query: 926 HWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNL 985
M E+E E + +E + SR L++ +D L
Sbjct: 625 --LVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL 682
Query: 986 SSMLHQRAEIP----WRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSAL 1041
S+ IP WR L+ ++ VF ++ + A +K
Sbjct: 683 STKEALDESIPPVSFWRIMKLNLTEWPYFVVG--VFCAIINGGLQPAFAIIFSK------ 734
Query: 1042 TLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLL 1101
+ + + +++++F L + + + T G + KRL +
Sbjct: 735 -IIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVF 793
Query: 1102 NRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYV 1159
++ + +F+ G++ R ++D + I S L ++++ + + +IS++
Sbjct: 794 RSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI-IISFI 852
Query: 1160 ----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1213
+ L+A++P+ + ++ A +D ++L+ + ++ E +E T+
Sbjct: 853 YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA-----TEAIENFRTV 907
Query: 1214 RAFRYEARFQQ---KLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNS 1270
+ E +F+ + L+ N++ + M Y +++
Sbjct: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
Query: 1271 LHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT---EAESYEG 1327
L LV + + M ++ + A ++ + I + KT ++ S EG
Sbjct: 968 LMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMI--IEKTPLIDSYSTEG 1025
Query: 1328 LLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSS 1386
L+ +L +G + + Y + PVL+ ++ + GQ + + G +G GKS+
Sbjct: 1026 LMPNTL-------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKST 1078
Query: 1387 FSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPER 1443
R D G +++DG +I +L + LR+ L I+ Q+P+LF +I N+ D R
Sbjct: 1079 VVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR 1138
Query: 1444 KCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFI 1503
S + A + A + +++LP + + G S GQ+Q +ARA VR+ I +
Sbjct: 1139 VVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
Query: 1504 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPE 1563
+DEAT+++D +E ++Q+ + A RT + IAHR+ TI +ADL++V + G + E +
Sbjct: 1199 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1258
Query: 1564 KLLSRKDSVFA 1574
+LL++K F+
Sbjct: 1259 QLLAQKGIYFS 1269
Score = 125 bits (313), Expect = 4e-28
Identities = 73/235 (31%), Positives = 127/235 (54%), Gaps = 2/235 (0%)
Query: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
+G ++ +N+ Y S + +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 389 KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE 448
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERK-CSDSTLWEALEIAQ 1458
G + +DG DI + + LR + ++ Q+PVLF+ TI N+ R+ + + +A++ A
Sbjct: 449 GMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 508
Query: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E +
Sbjct: 509 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 568
Query: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
+Q + A RT + IAHR+ T+ +AD++ G I+E ++L+ K F
Sbjct: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
Score = 98.6 bits (244), Expect = 4e-20
Identities = 66/227 (29%), Positives = 120/227 (52%), Gaps = 22/227 (9%)
Query: 690 PDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGE 749
PD IP L +++ + +GQ +VG GCGKS+++ ++G V L EI
Sbjct: 1048 PD-IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVL---LDGKEIKR 1103
Query: 750 DPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEA---C 805
L+++ R + SQ+P L + ++ ENI + + ++ A
Sbjct: 1104 -----------LNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
Query: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
++ I+ LP+ T++G++G LSGGQ+QRI++ARAL + +++ LD+ SALD
Sbjct: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
Query: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 1213 VVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1256
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 207 bits (527), Expect = 6e-53
Identities = 213/928 (22%), Positives = 396/928 (42%), Gaps = 114/928 (12%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
+ L + +++ GQ +VG GCGKS+ + +Q++ DP
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
Query: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
DIR R + SQ+P L + T+ ENI + K ++
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
+ I LP T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
+ A L+ R+ RT +++ H+L + +AD I +DG I +G+ + + E F+
Sbjct: 570 EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
Query: 926 HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979
L+N Q Q E E E+ AT P G + + + + +
Sbjct: 627 ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
Query: 980 EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025
E D L + + + E P+ CA +++ G+ ++FS+++
Sbjct: 683 VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
Query: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085
+ + Q+C +++++F L + + T
Sbjct: 737 ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
Query: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
G + +RL ++ M +F+ G++ R ++D + Q T L
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
Query: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197
+ + +IS++ + L+A++P+ V ++ A RD ++L+ ++
Sbjct: 836 AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
Query: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLE-----YTDSNNIASLF-LTAANRWLEVRM 1251
E +E + T+ + E +F+ +E Y +S A ++ +T + +
Sbjct: 896 A-----TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF 950
Query: 1252 EYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311
Y G C A + I N R LV + + + + + + A +L +
Sbjct: 951 SYAG-CFRFGAYL--IVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007
Query: 1312 KRIHGLLKT-EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIA 1369
+ ++ S EGL +G I + Y + PVL+ ++ +
Sbjct: 1008 FMLFERQPLIDSYSEEGLKPDKF-------EGNITFNEVVFNYPTRANVPVLQGLSLEVK 1060
Query: 1370 PGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPV 1429
GQ + + G +G GKS+ R D G +++DG + KL + LR++L I+ Q+P+
Sbjct: 1061 KGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPI 1120
Query: 1430 LFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQR 1486
LF +I N+ D R S + A + A + ++ LP + + + G S GQ+
Sbjct: 1121 LFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1180
Query: 1487 QLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSAD 1546
Q +ARA +R+ I ++DEAT+++D +E ++Q+ + A RT + IAHR+ TI +AD
Sbjct: 1181 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNAD 1240
Query: 1547 LVIVLKRGAILEFDKPEKLLSRKDSVFA 1574
L++V + G + E ++LL++K F+
Sbjct: 1241 LIVVFQNGRVKEHGTHQQLLAQKGIYFS 1268
Score = 120 bits (302), Expect = 8e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)
Query: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
+G ++ ++ Y S +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458
G I IDG DI ++ LR + ++ Q+PVLFS TI N+ R + + +A++ A
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
+Q + A RT + IAHR+ T+ +AD++ + G I+E +L+ +K+ V+ V
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
Score = 107 bits (266), Expect = 1e-22
Identities = 64/228 (28%), Positives = 119/228 (52%), Gaps = 21/228 (9%)
Query: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
T +P L +++ + +GQ +VG GCGKS+++ ++G V
Sbjct: 1045 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG------- 1097
Query: 749 EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804
+ A L+++ R + SQ+P L + ++ ENI + ++ +A
Sbjct: 1098 -------QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
Query: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
++ P I+ LPH +T++G++G LSGGQ+QRI++ARAL + ++ LD+ SALD
Sbjct: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
Query: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 1211 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1255
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 202 bits (515), Expect = 2e-51
Identities = 205/920 (22%), Positives = 387/920 (42%), Gaps = 145/920 (15%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
+ L + +++ GQ +VG GCGKS+ + +Q++ DP
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
Query: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
DIR R + SQ+P L + T+ ENI + K ++
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
+ I LP T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
+ A L+ R+ RT +++ H+L + +AD I +DG I +G+ + + E F+
Sbjct: 570 EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
Query: 926 HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979
L+N Q Q E E E+ AT P G + + + + +
Sbjct: 627 ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
Query: 980 EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025
E D L + + + E P+ CA +++ G+ ++FS+++
Sbjct: 683 VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
Query: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085
+ + Q+C +++++F L + + T
Sbjct: 737 ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
Query: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
G + +RL ++ M +F+ G++ R ++D + Q T L
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
Query: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197
+ + +IS++ + L+A++P+ V ++ A RD ++L+ ++
Sbjct: 836 AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
Query: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
E +E + T+ + E +F+ S+++ V +
Sbjct: 896 A-----TEAIENIRTVVSLTQERKFE-------------SMYVEKLYGPYRVFSAIVFGA 937
Query: 1258 VVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGL 1317
V L A + + +LSA + + ++ +Y GL
Sbjct: 938 VALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSE-------------------EGL 978
Query: 1318 LKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGIC 1377
+ + +EG + + + N+P + + PVL+ ++ + GQ + +
Sbjct: 979 ---KPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKGQTLALV 1021
Query: 1378 GRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF 1437
G +G GKS+ R D G +++DG + KL + LR++L I+ Q+P+LF +I
Sbjct: 1022 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1081
Query: 1438 NL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARA 1494
N+ D R S + A + A + ++ LP + + + G S GQ+Q +ARA
Sbjct: 1082 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1141
Query: 1495 FVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRG 1554
+R+ I ++DEAT+++D +E ++Q+ + A RT + IAHR+ TI +ADL++V + G
Sbjct: 1142 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1201
Query: 1555 AILEFDKPEKLLSRKDSVFA 1574
+ E ++LL++K F+
Sbjct: 1202 RVKEHGTHQQLLAQKGIYFS 1221
Score = 120 bits (302), Expect = 8e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)
Query: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
+G ++ ++ Y S +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458
G I IDG DI ++ LR + ++ Q+PVLFS TI N+ R + + +A++ A
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
+Q + A RT + IAHR+ T+ +AD++ + G I+E +L+ +K+ V+ V
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
Score = 107 bits (266), Expect = 1e-22
Identities = 64/228 (28%), Positives = 119/228 (52%), Gaps = 21/228 (9%)
Query: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
T +P L +++ + +GQ +VG GCGKS+++ ++G V
Sbjct: 998 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG------- 1050
Query: 749 EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804
+ A L+++ R + SQ+P L + ++ ENI + ++ +A
Sbjct: 1051 -------QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
Query: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
++ P I+ LPH +T++G++G LSGGQ+QRI++ARAL + ++ LD+ SALD
Sbjct: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
Query: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 1164 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1208
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 200 bits (509), Expect = 8e-51
Identities = 213/935 (22%), Positives = 396/935 (42%), Gaps = 121/935 (12%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
+ L + +++ GQ +VG GCGKS+ + +Q++ DP
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
Query: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
DIR R + SQ+P L + T+ ENI + K ++
Sbjct: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
Query: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
+ I LP T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD
Sbjct: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
Query: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
+ A L+ R+ RT +++ H+L + +AD I +DG I +G+ + + E F+
Sbjct: 570 EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
Query: 926 HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979
L+N Q Q E E E+ AT P G + + + + +
Sbjct: 627 ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
Query: 980 EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025
E D L + + + E P+ CA +++ G+ ++FS+++
Sbjct: 683 VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
Query: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085
+ + Q+C +++++F L + + T
Sbjct: 737 ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
Query: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
G + +RL ++ M +F+ G++ R ++D + Q T L
Sbjct: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
Query: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197
+ + +IS++ + L+A++P+ V ++ A RD ++L+ ++
Sbjct: 836 AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
Query: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLE-----YTDSNNIASLF-LTAANRWLEVRM 1251
E +E + T+ + E +F+ +E Y +S A ++ +T + +
Sbjct: 896 A-----TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF 950
Query: 1252 EYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311
Y G C A + I N R LV + + + + + + A +L +
Sbjct: 951 SYAG-CFRFGAYL--IVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007
Query: 1312 KRIHGLLKT-EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIA 1369
+ ++ S EGL +G I + Y + PVL+ ++ +
Sbjct: 1008 FMLFERQPLIDSYSEEGLKPDKF-------EGNITFNEVVFNYPTRANVPVLQGLSLEVK 1060
Query: 1370 PGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHI-------IIDGIDIAKLPLHTLRSRLS 1422
GQ + + G +G GKS+ R D G + ++DG + KL + LR++L
Sbjct: 1061 KGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLG 1120
Query: 1423 IILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGE 1479
I+ Q+P+LF +I N+ D R S + A + A + ++ LP + + + G
Sbjct: 1121 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1180
Query: 1480 NFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1539
S GQ+Q +ARA +R+ I ++DEAT+++D +E ++Q+ + A RT + IAHR+
Sbjct: 1181 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1240
Query: 1540 HTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFA 1574
TI +ADL++V + G + E ++LL++K F+
Sbjct: 1241 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
Score = 120 bits (302), Expect = 8e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)
Query: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
+G ++ ++ Y S +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458
G I IDG DI ++ LR + ++ Q+PVLFS TI N+ R + + +A++ A
Sbjct: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
Query: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E
Sbjct: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
Query: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
+Q + A RT + IAHR+ T+ +AD++ + G I+E +L+ +K+ V+ V
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
Score = 108 bits (270), Expect = 4e-23
Identities = 67/228 (29%), Positives = 123/228 (53%), Gaps = 14/228 (6%)
Query: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
T +P L +++ + +GQ +VG GCGKS+++ ++G VF + G
Sbjct: 1045 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVF------VDFG 1098
Query: 749 EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804
+E A L+++ R + SQ+P L + ++ ENI + ++ +A
Sbjct: 1099 FQLLDGQE-AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
Query: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
++ P I+ LPH +T++G++G LSGGQ+QRI++ARAL + ++ LD+ SALD
Sbjct: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
Query: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 1218 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1262
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 185 bits (470), Expect = 3e-46
Identities = 224/931 (24%), Positives = 397/931 (42%), Gaps = 104/931 (11%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
+ L+++ + I G++T +VG G GKS+ AL +Q+ DP
Sbjct: 435 VKILNDLNMVIKPGEMTALVGPSGAGKST----ALQLIQRFY---------------DPC 475
Query: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF--ESPFNKQRYKMVIEA 804
T DIR R + Q+P L + T+ ENI + E + + EA
Sbjct: 476 EGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEA 535
Query: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
+ +D LP T +GE G +SGGQ+QR+++ARAL ++ ++ LD SALD + S
Sbjct: 536 NAYNFIMD-LPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NES 593
Query: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLF 924
+ ++Q + ++ T++ V H+L + AD II + GT GT ++ + F
Sbjct: 594 EAMVQEVLSKIQHG--HTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
Query: 925 EHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDE------EEEEEEAAE 978
TL ++ +Q L +E + + ATE L+R S G QD + + + +
Sbjct: 652 T-LVTLQSQGNQALNEEDIKD--ATEDDM-LARTFSR--GSYQDSLRASIRQRSKSQLSY 705
Query: 979 SEEDDNLSSMLHQRA--------EIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAID 1030
+ L+ + H+ +IP + + IL S + +L V A++
Sbjct: 706 LVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVN 765
Query: 1031 YWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGL 1090
+ + + +E ++F + + + + +G
Sbjct: 766 GTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGE 825
Query: 1091 KVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLSRS-TL 1147
+ KRL + ++ + +F+ G++ R ++D + + S + + S T
Sbjct: 826 LLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTN 885
Query: 1148 LCVSALAVISYVTPVFLVALLPLAIVCYF----------IQKYFRVASRDLQQLDDTTQL 1197
+ V+ + S+ + LV I+C+F + ASRD Q L+ Q+
Sbjct: 886 VTVAMIIAFSFSWKLSLV------ILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQI 939
Query: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
E + + T+ E RF + L + F TA + G C
Sbjct: 940 T-----NEALSNIRTVAGIGKERRFIEAL-----ETELEKPFKTAIQK-----ANIYGFC 984
Query: 1258 VVLIAAVTSISNSLHRELSAGLV---GLGLTYALMVSNYLNWMVRNLADMELQLGAVKRI 1314
+ I+NS L+ GL +Y V + + L + +
Sbjct: 985 FAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG----RAFSYTPS 1040
Query: 1315 HGLLKTEAESYEGLL--APSLIPKN-----WPD-QGKIQIQNLSVRYDSSL-KPVLKHVN 1365
+ K A + LL P + N W + QGKI + Y S VL ++
Sbjct: 1041 YAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLS 1100
Query: 1366 ALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIIL 1425
I+PGQ + G +G GKS+ R D +G ++IDG D K+ + LRS + I+
Sbjct: 1101 VSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVS 1160
Query: 1426 QDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
Q+PVLF+ +I N+ D ++ + A + AQL V +LP + + G S
Sbjct: 1161 QEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLS 1220
Query: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
+G++Q +ARA VR I ++DEAT+++D +E +Q + A RT + IAHR+ TI
Sbjct: 1221 RGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTI 1280
Query: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
+AD++ V+ +G ++E E+L+++K + +
Sbjct: 1281 QNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
Score = 134 bits (336), Expect = 9e-31
Identities = 78/237 (32%), Positives = 134/237 (56%), Gaps = 6/237 (2%)
Query: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
+G+I+ N++ Y S + +L +N +I PG+ + G +G+GKS+ R D E
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQL 1459
G + +DG DI L + LR ++ I+ Q+PVLFS TI N+ R+ D+T+ + ++ A+
Sbjct: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DATMEDIVQAAKE 534
Query: 1460 KLV---VKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE 1516
+ LP D ++ EGG S GQ+Q +ARA +R I ++D AT+++D +E
Sbjct: 535 ANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
Query: 1517 NILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
++Q+V+ T++++AHR+ T+ +AD +I + G +E E+LL RK F
Sbjct: 595 AMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 181 bits (460), Expect = 4e-45
Identities = 195/837 (23%), Positives = 361/837 (43%), Gaps = 78/837 (9%)
Query: 766 RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGE 824
R + SQ+P L T+ NI + + + + I P+ T +GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 825 RGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVV 884
+G +SGGQ+QRI++ARAL ++ ++ LD+ SALD S +QA + + + RT +
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTTI 132
Query: 885 LVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL-MNRQDQELEKETV 943
+V H+L + AD I+ +KDG + +G + + + + + D+++E T
Sbjct: 133 VVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTY 192
Query: 944 -TERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAK 1002
TERK P +++ S D + + EE + + E L + + E P+
Sbjct: 193 STERKTNSLPLHSVKSIKS-DFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPF----- 246
Query: 1003 YLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTL--DQ 1060
++L +L H V I A +T N + TL D
Sbjct: 247 ------VVLGTLASVLNGTVHPVFSII---------FAKIITMFGNN----DKTTLKHDA 287
Query: 1061 TVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLG 1118
+Y+M+F +L + V + + G + RL ++ + +F+ G
Sbjct: 288 EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTG 347
Query: 1119 SILNRFSSDCNTIDQHIPSTLECLSRSTL---LCVSALAVISYVTPVFLVALLPLAIVCY 1175
+ + D I S + L+++ L V + + ++++ P+ V
Sbjct: 348 GLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
Query: 1176 FIQKYFRV--ASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
I+ A++D Q+L ++ E +E + TI + E F+Q E
Sbjct: 408 MIETAAMTGFANKDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEE----- 457
Query: 1234 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY 1293
L +R + + IG+C A + + A L+ G M
Sbjct: 458 -----MLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGR----MTPEG 508
Query: 1294 LNWMVRNLADMELQLGAVKRI---HGLLKTEAESYEGLLA--PSLIPKNW----PD--QG 1342
+ + +A + +G + + K+ A LL P++ ++ PD +G
Sbjct: 509 MFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEG 568
Query: 1343 KIQIQNLSVRYDSSLKP---VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
++ + +S Y +P +L+ ++ I G+ + G +G GKS+ R+ D +
Sbjct: 569 NLEFREVSFFYPC--RPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
Query: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEI 1456
G ++ DG+D +L + LRS+++I+ Q+PVLF+ +I N+ D R + EA
Sbjct: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
Query: 1457 AQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE 1516
A + ++ LP + + G S GQ+Q +ARA ++K I ++DEAT+++D +E
Sbjct: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
Query: 1517 NILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
++Q + A RT + + HR+ I +ADL++VL G I E ++LL +D F
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
Score = 99.0 bits (245), Expect = 3e-20
Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 22/239 (9%)
Query: 685 YFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPD 744
++ PD + L +++ I RG+ VG GCGKS+ + V G V + +
Sbjct: 578 FYPCRPD-VFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD- 635
Query: 745 SEIGEDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKM 800
A +L+++ R +A Q+P L N ++ ENI + K
Sbjct: 636 -------------AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKE 682
Query: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
A ++ I+ LP TQ+G +G LSGGQ+QR+++ARAL Q ++ LD+ SALD
Sbjct: 683 AANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALD 742
Query: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRS 919
+ S+ ++Q L+ R RT ++VTH+L + +AD I+ + +G I+ +GT ++ R+
Sbjct: 743 -NDSEKVVQHA-LDKARTG-RTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 798
Score = 96.7 bits (239), Expect = 2e-19
Identities = 55/179 (30%), Positives = 94/179 (52%), Gaps = 1/179 (0%)
Query: 1403 IIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERK-CSDSTLWEALEIAQLKL 1461
++D DI L + R + ++ Q+PVLF TI N+ R +D + A A
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1462 VVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQK 1521
+ P + ++ E G S GQ+Q +ARA VR I I+DEAT+++D +++ +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1522 VVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRAD 1580
+ A RT + +AHR+ TI SADL++ LK G + E +L++++ ++ + D
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 168 bits (425), Expect = 4e-41
Identities = 134/509 (26%), Positives = 250/509 (49%), Gaps = 38/509 (7%)
Query: 1085 VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSR 1144
++ +G ++ RL SL + I+ + FF+ T G ++NR SSD + + + L R
Sbjct: 236 MQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLR 295
Query: 1145 STLLCVSALAVISYVTP---VFLVALLP-LAIVCYFIQKYFRVASRDLQQ-LDDTTQLPL 1199
+ ++++ +V+P F+++++P ++I+ +Y R ++ Q L TQL
Sbjct: 296 AGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLA- 354
Query: 1200 LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC-- 1257
E + + T+RAF E +K D + A + R + GA
Sbjct: 355 ----EERIGNVRTVRAFGKEMTEIEKYASKVDH------VMQLARKEAFARAGFFGATGL 404
Query: 1258 ---VVLIAAVTS---ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311
+++++ + + S H ++ G + L YA V + + +++ LGA
Sbjct: 405 SGNLIVLSVLYKGGLLMGSAH--MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAG 462
Query: 1312 KRIHGLLKTEAES--YEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALI 1368
R+ LL+ E + EG++ L K++ QG ++ +N+ Y + + P+ + + I
Sbjct: 463 GRLWELLEREPKLPFNEGVI---LNEKSF--QGALEFKNVHFAYPARPEVPIFQDFSLSI 517
Query: 1369 APGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDP 1428
G + G +GSGKS+ R+ D G I +DG DI +L LRS++ + Q+P
Sbjct: 518 PSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEP 577
Query: 1429 VLFSGTIRFNL----DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQG 1484
+LFS +I N+ D + + E+A ++ P G + ++ E G S G
Sbjct: 578 ILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGG 637
Query: 1485 QRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILS 1544
Q+Q +ARA ++ I ++DEAT+++D E ++Q+ + RTV+ IAHR+ TI +
Sbjct: 638 QKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKN 697
Query: 1545 ADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
A++V VL +G I E+ K E+LLS+ + ++
Sbjct: 698 ANMVAVLDQGKITEYGKHEELLSKPNGIY 726
Score = 102 bits (254), Expect = 3e-21
Identities = 72/247 (29%), Positives = 126/247 (51%), Gaps = 25/247 (10%)
Query: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGE-DP 751
+P + ++ IP G +T +VG G GKS++L L SG + SL +I + +P
Sbjct: 507 VPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTI---SLDGHDIRQLNP 563
Query: 752 SPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIF----ESPFNKQRYKMVIEACSL 807
+ R + SQ+P L + ++ ENI + S + + V E +
Sbjct: 564 -----------VWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 808 QPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHL 867
I P G T +GE+G+ LSGGQ+QRI++ARAL ++ ++ LD+ SALD +++L
Sbjct: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYL 671
Query: 868 MQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHW 927
+Q + L+ D RTV+++ H+L + +A+ + + G I G ++ ++
Sbjct: 672 VQEALDRLM--DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY--- 726
Query: 928 KTLMNRQ 934
+ LMN+Q
Sbjct: 727 RKLMNKQ 733
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 148 bits (373), Expect = 5e-35
Identities = 121/482 (25%), Positives = 226/482 (46%), Gaps = 29/482 (6%)
Query: 1087 WTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRST 1146
+T ++ R+ L + ++ + FF+ T G + +R SSD + +P L RS
Sbjct: 216 YTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSL 275
Query: 1147 LLCVSALAVISYVTP-VFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE 1205
+ V + ++P + L++LL + + Y L+++ D E
Sbjct: 276 VKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAG-QVVRE 334
Query: 1206 TVEGLTTIRAF--------RYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
V GL T+R+F RY+ +Q Y + +L+L L R+ ++G
Sbjct: 335 AVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL------LVRRVLHLGVQ 388
Query: 1258 VVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGL 1317
+++++ + EL+ G + + Y V +Y+ +V DM +GA +++
Sbjct: 389 MLMLSC--GLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSY 446
Query: 1318 LKTEAE-SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALIAPGQKIG 1375
+ + G LAP+ + QG ++ Q++S Y + +PVLK + + PG+
Sbjct: 447 MDRQPNLPSPGTLAPTTL------QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
Query: 1376 ICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTI 1435
+ G GSGKS+ + + G +++D I++ L S++ + Q+PVLFSG++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
Query: 1436 RFNLD-PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARA 1494
R N+ + C D + A + A ++ + G+ + E G + GQ+Q +ARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
Query: 1495 FVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRG 1554
VR + I+DEAT+++D+ E LQ + DRTV+ IAHR+ + A ++VL+ G
Sbjct: 621 LVRDPRVLILDEATSALDVQCEQALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEG 678
Query: 1555 AI 1556
+
Sbjct: 679 KL 680
Score = 87.4 bits (215), Expect = 1e-16
Identities = 62/225 (27%), Positives = 101/225 (44%), Gaps = 19/225 (8%)
Query: 694 PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSP 753
P L +T + G++T +VG G GKS++ Q G V P S+
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEH---- 539
Query: 754 ERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFE-SPFNKQRYKMVIEACSLQPDID 812
V Q+P L + +V NI + + +A I
Sbjct: 540 ---------CYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQ 590
Query: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
+ HG T +GE+G L+ GQ+QR+++ARAL + V+ LD+ SALD+ L
Sbjct: 591 EMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWN- 649
Query: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
R D RTV+++ H+LQ + A I+ +++G +Q+ L++ Q
Sbjct: 650 ---SRGD-RTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,883,524
Number of Sequences: 37866
Number of extensions: 2292226
Number of successful extensions: 15670
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 14251
Number of HSP's gapped (non-prelim): 813
length of query: 1581
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1465
effective length of database: 13,855,062
effective search space: 20297665830
effective search space used: 20297665830
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.