Search of human proteins with 117606360

Search of human proteins with 117606360

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117606360 ADP-ribosylation factor guanine nucleotide factor
6 isoform a [Homo sapiens]
         (1047 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...  2095   0.0  
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...  1009   0.0  
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    625   e-179
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      588   e-167
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    459   e-129
gi|4758968 cytohesin 3 [Homo sapiens]                                 118   3e-26
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       114   5e-25
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     113   8e-25
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     109   2e-23
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       109   2e-23
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   103   1e-21
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   100   1e-20
gi|7019505 cytohesin 4 [Homo sapiens]                                  97   8e-20
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                  91   6e-18
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]       89   2e-17
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]        89   2e-17
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...    89   3e-17
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]        84   5e-16
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        84   5e-16
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    68   5e-11
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]           62   2e-09
gi|67782321 spectrin beta isoform a [Homo sapiens]                     60   1e-08
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    59   2e-08
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           56   2e-07
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           55   5e-07
gi|48928044 F-box only protein 8 [Homo sapiens]                        54   8e-07
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...    53   1e-06
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    49   3e-05
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    48   4e-05
gi|20149626 pleckstrin homology domain containing, family O memb...    45   5e-04

>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
            isoform a [Homo sapiens]
          Length = 1047

 Score = 2095 bits (5429), Expect = 0.0
 Identities = 1047/1047 (100%), Positives = 1047/1047 (100%)

Query: 1    MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEF 60
            MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEF
Sbjct: 1    MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEF 60

Query: 61   PEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQ 120
            PEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQ
Sbjct: 61   PEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQ 120

Query: 121  SHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKT 180
            SHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKT
Sbjct: 121  SHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKT 180

Query: 181  QRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGA 240
            QRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGA
Sbjct: 181  QRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGA 240

Query: 241  VCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVE 300
            VCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVE
Sbjct: 241  VCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVE 300

Query: 301  FQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENV 360
            FQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENV
Sbjct: 301  FQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENV 360

Query: 361  WDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH 420
            WDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH
Sbjct: 361  WDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH 420

Query: 421  VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTP 480
            VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTP
Sbjct: 421  VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTP 480

Query: 481  MIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEI 540
            MIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEI
Sbjct: 481  MIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEI 540

Query: 541  AFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKR 600
            AFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKR
Sbjct: 541  AFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKR 600

Query: 601  SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFS 660
            SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFS
Sbjct: 601  SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFS 660

Query: 661  NRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSK 720
            NRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSK
Sbjct: 661  NRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSK 720

Query: 721  DLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHD 780
            DLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHD
Sbjct: 721  DLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHD 780

Query: 781  PNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEED 840
            PNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEED
Sbjct: 781  PNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEED 840

Query: 841  LKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFS 900
            LKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFS
Sbjct: 841  LKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFS 900

Query: 901  APPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKA 960
            APPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKA
Sbjct: 901  APPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKA 960

Query: 961  KDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSP 1020
            KDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSP
Sbjct: 961  KDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSP 1020

Query: 1021 ITAKVKRNVSERKDHRPETPSIKQKVT 1047
            ITAKVKRNVSERKDHRPETPSIKQKVT
Sbjct: 1021 ITAKVKRNVSERKDHRPETPSIKQKVT 1047


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
            isoform b [Homo sapiens]
          Length = 513

 Score = 1009 bits (2609), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 546  NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK 605
            NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK
Sbjct: 12   NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK 71

Query: 606  HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY 665
            HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY
Sbjct: 72   HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY 131

Query: 666  CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA 725
            CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA
Sbjct: 132  CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA 191

Query: 726  LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV 785
            LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV
Sbjct: 192  LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV 251

Query: 786  YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV 845
            YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV
Sbjct: 252  YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV 311

Query: 846  SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP 905
            SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP
Sbjct: 312  SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP 371

Query: 906  AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE 965
            AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE
Sbjct: 372  AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE 431

Query: 966  YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV 1025
            YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV
Sbjct: 432  YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV 491

Query: 1026 KRNVSERKDHRPETPSIKQKVT 1047
            KRNVSERKDHRPETPSIKQKVT
Sbjct: 492  KRNVSERKDHRPETPSIKQKVT 513


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  625 bits (1612), Expect = e-179
 Identities = 339/629 (53%), Positives = 434/629 (68%), Gaps = 45/629 (7%)

Query: 430  GPGYTEDSTDVYSSQFETILDNTSL----YYSAESLE--TLYSEPDSYFSFEMPLTPMIQ 483
            GPG   D  D +S+ FE IL++  L    Y S +SL+  +L  E DS  SFE PLTP+IQ
Sbjct: 127  GPG-EPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQ 185

Query: 484  QRIKE----------GGQFLERTSG--GGHQDI-------LSVSADGGIVMGYS-SGVTN 523
            QR ++          G    E   G  GG  ++       +S S    ++   S   + N
Sbjct: 186  QRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPN 245

Query: 524  GLND-------ASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSN 576
            G ++         +    + T ++    S+  +K    ++ SE+ S+E LE  + + L+N
Sbjct: 246  GFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLAN 305

Query: 577  GTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSL 636
            G     EAA RLA+RLY L+ F+R DVA+ LGKNNEFS+LVA EYL FFDF+G+TLD +L
Sbjct: 306  GCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGAL 365

Query: 637  RYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNI 696
            R F KAF L+GETQERERVL HFS RY  CNPD   S+DG+H LTCA+MLLNTDLHGHNI
Sbjct: 366  RTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNI 425

Query: 697  GKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKA 756
            GKKM+CQ+FIANL  +N+G DF+KDLLK LYNSIKNEKLEWA+D++E +KS SE  ++K 
Sbjct: 426  GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKF 485

Query: 757  NGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYA 816
             GT  K ++RI    NPFLD+P   +A  YK G L RK HADMDGK+TPRG+RGWK FYA
Sbjct: 486  -GTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYA 544

Query: 817  VLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLL 876
            VLKGT+LYLQKDEY+P+KALSE DLKNA+ VHHALA++A+DY KK NV KLKTADWRV L
Sbjct: 545  VLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFL 604

Query: 877  FQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHE 936
            FQ  S EEM  WI +IN VAA+FSAP FPAA+ S KKF RPLLP+ TT+L QEEQL+SHE
Sbjct: 605  FQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHE 664

Query: 937  SKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL----KEGGK 992
            +KL+Q+T ELAEHR +P ++ +K+K+ +EY+LK+HYL FEK+RYE Y+ +L    K G  
Sbjct: 665  NKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSD 724

Query: 993  EL------LSNDESEAAGLKKSHSSPSLN 1015
            +L      L+  E +   L+K+HSSP+L+
Sbjct: 725  DLERIEARLATLEGDDPSLRKTHSSPALS 753


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  588 bits (1515), Expect = e-167
 Identities = 329/638 (51%), Positives = 428/638 (67%), Gaps = 52/638 (8%)

Query: 430  GPGYTEDSTDVYSSQFETILDNT----SLYYSAESLETLYSEPDS---YFSFEMPLTPMI 482
            G   + D  D +S  FE IL++     + Y S  SLE L S   +   +F+FE+P  P  
Sbjct: 391  GTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPA 450

Query: 483  QQRIKEGGQFL---ERTSGGGHQDILSVSADGGIVMGYS-------SGVTNGLNDAS--- 529
             +        L   E  SG       S +ADG              + +  G    S   
Sbjct: 451  PRPDPPAPAPLAPLEPDSG------TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCH 504

Query: 530  --DSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKR 587
              DS+     P     GS   +     ++ SE+ STE L   + + LSNG  +++EAA+R
Sbjct: 505  SEDSLGLGAAP----LGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQR 560

Query: 588  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
            LAKRLY+LD F+++DVA+HLGKNN+FSKLVA EYLKFF FTGMTLDQ+LR F K  +L+G
Sbjct: 561  LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620

Query: 648  ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
            ETQERERVL HFS RYF CNP+ ++S+DG H LTCA+MLLNTDLHGHNIGK+MTC +FI 
Sbjct: 621  ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680

Query: 708  NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767
            NL+G+N+G DF ++LLKALY+SIKNEKL+WA+D+EE ++S SE  +      +PK I RI
Sbjct: 681  NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP-----NPKVIKRI 735

Query: 768  ----GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVL 823
                GS ++PFLD+  +P AAVYK G L RK+HAD D +KTPRGKRGWK+F+ +LKG +L
Sbjct: 736  SGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMIL 795

Query: 824  YLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPE 883
            YLQK+EYKP KALSE +LKNA+S+HHALA++A+DY K+P+VF L+TADWRV LFQ  S E
Sbjct: 796  YLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLE 855

Query: 884  EMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQIT 943
            +MQ WI +IN VAA+FSAPPFPAA+ SQKKFSRPLLP+  T+LSQEEQ+++HE+KLK + 
Sbjct: 856  QMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMA 915

Query: 944  TELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSI----LKEGGKEL----- 994
            +EL EHR+    KK + K+ +E + K+ YLEFEK+RY  Y ++    LK G +EL     
Sbjct: 916  SELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEA 975

Query: 995  -LSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSE 1031
             L+   S   GL  SHSSPSL P  S    + +R+ SE
Sbjct: 976  ALAQAGSTEDGLPPSHSSPSLQPKPSS-QPRAQRHSSE 1012


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  459 bits (1181), Expect = e-129
 Identities = 242/487 (49%), Positives = 324/487 (66%), Gaps = 31/487 (6%)

Query: 572  ENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMT 631
            + L+NG  +N + A  LA RLY+L+ F++S+VA +L KNN+FS+ VAEEYL FF F G +
Sbjct: 576  DKLANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQS 634

Query: 632  LDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDL 691
            LD++LR F +A  L GETQERER+L  FS R+ +CNP    S D VH LTCAIMLLNTDL
Sbjct: 635  LDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDL 694

Query: 692  HGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSES 751
            HG NIGK M+CQEFI NL G+ +G +F K+LLKALY SI++EKLEWAVD+E+  +     
Sbjct: 695  HGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR----- 749

Query: 752  TEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGW 811
              EKA  + P      G  + PFL +  DP    YK G LARK+H D DGKKTP GKRGW
Sbjct: 750  -PEKAQPSLP-----AGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGW 803

Query: 812  KTFYAVLKGTVLYLQK---DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLK 868
            K F+ +L+G VLY  K   D     ++L  + +   V VHH+LA+ AT Y KKP+VF+L+
Sbjct: 804  KMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLR 863

Query: 869  TADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ 928
            TADWR+ LFQ  + +EM  WI +IN  AA  SAPPFPAA+GSQ++F RP+LP    + S 
Sbjct: 864  TADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSL 923

Query: 929  EEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL- 987
            EEQ +SHE+ L     +L + +   P+++ + ++++E++L+  YLE+EKTRYE YV +L 
Sbjct: 924  EEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLV 983

Query: 988  --------------KEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERK 1033
                          ++ G+E     E + + LKKSHSSPSL+ D +P TAKVKRN+SER+
Sbjct: 984  ARLHCPSDALDLWEEQLGREAGGTREPKLS-LKKSHSSPSLHQDEAPTTAKVKRNISERR 1042

Query: 1034 DHRPETP 1040
             +R   P
Sbjct: 1043 TYRKIIP 1049


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  118 bits (295), Expect = 3e-26
 Identities = 59/154 (38%), Positives = 96/154 (62%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ LY+ +   ++ +  +LG+ +EF+  V + +++  +F  + L Q+LR F  +F L G
Sbjct: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160

Query: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
           E Q+ +R++  F++RY  CNP    S D  + L+ AI++LNT LH HN+  K T + FIA
Sbjct: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220

Query: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741
             +G+NEG D  ++LL+ LY SIKNE  +   DD
Sbjct: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  114 bits (285), Expect = 5e-25
 Identities = 97/347 (27%), Positives = 159/347 (45%), Gaps = 74/347 (21%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156

Query: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216

Query: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251

Query: 768 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 827
              T+ F     +P+    + G+L +     + G +    KR W     +L    LY   
Sbjct: 252 NDLTHTFF----NPD----REGWLLK-----LGGGRVKTWKRRW----FILTDNCLYY-- 292

Query: 828 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 873
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 293 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 346

Query: 874 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 913
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 347 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 390


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  113 bits (283), Expect = 8e-25
 Identities = 96/347 (27%), Positives = 160/347 (46%), Gaps = 75/347 (21%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156

Query: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216

Query: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251

Query: 768 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 827
              T+ F     +P+    + G+L +     + G+      + WK  + +L    LY   
Sbjct: 252 NDLTHTFF----NPD----REGWLLK-----LGGR-----VKTWKRRWFILTDNCLYY-- 291

Query: 828 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 873
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 292 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 345

Query: 874 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 913
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 346 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 389


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  109 bits (272), Expect = 2e-23
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 586 KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 645
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153

Query: 646 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213

Query: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  109 bits (272), Expect = 2e-23
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 586 KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 645
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153

Query: 646 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213

Query: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  103 bits (256), Expect = 1e-21
 Identities = 50/120 (41%), Positives = 77/120 (64%), Gaps = 3/120 (2%)

Query: 619 EEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVH 678
           E ++  F F G+ LD++LR + +AF L GE    +R+L  F+ R+  CN    A+ D   
Sbjct: 765 ESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF 824

Query: 679 CLTCAIMLLNTDLHGHNIGKK---MTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKL 735
            L  A+++LNTD H HN+ K+   MT +EF  NL+GVN G DF +D+L+ +Y++IKNE++
Sbjct: 825 SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI 884


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 54/169 (31%), Positives = 98/169 (57%), Gaps = 4/169 (2%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ L+Q +R   + V + LG N++F+K V   Y+   DF+G     +LR F + F L G
Sbjct: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792

Query: 648 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852

Query: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 754
           I   +G+N+  D  ++ L A+YN I  +K+  ++ + ++   P++S+++
Sbjct: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI--SMKETKELTIPTKSSKQ 899


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 48/154 (31%), Positives = 88/154 (57%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ LY+ +   ++ +  +LG+ +  +  V + ++   +F  + L Q+LR F  +F L G
Sbjct: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155

Query: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
           E Q+ +R++  F+ RY  CNP    S D  + L+ +I++LNT LH  N+  +   + F++
Sbjct: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215

Query: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741
             +G+N G D  +D L+ L++SIK+E      DD
Sbjct: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 53/155 (34%), Positives = 90/155 (58%), Gaps = 6/155 (3%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNN-EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442

Query: 647 GETQERERVLIHFSNRYFYCNPDTIA---SQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701
           GE Q+ ER++  FS RY  CNP+ +    + D +  L  AI+LLNTD++  NI   +KM 
Sbjct: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502

Query: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLE 736
            ++FI NL+GV++G D  ++L+  +Y  I+ ++L+
Sbjct: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 588 LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604

Query: 647 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664

Query: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 761
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 720

Query: 762 KTISRIGSTTNPFLDIPH 779
             I  +       L +PH
Sbjct: 721 --IGSLHPGLGCVLSLPH 736


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 588 LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618

Query: 647 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678

Query: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 761
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 734

Query: 762 KTISRIGSTTNPFLDIPH 779
             I  +       L +PH
Sbjct: 735 --IGSLHPGLGCVLSLPH 750


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 51/169 (30%), Positives = 92/169 (54%), Gaps = 4/169 (2%)

Query: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
           +A+ L+Q +R   + V   LG +  F+K V   Y+   DF       +LR F + F L G
Sbjct: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737

Query: 648 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797

Query: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 754
           I   +G+N+  D  ++ L ++Y  I+ +K+  A+ + ++    ++ST++
Sbjct: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI--AMKETKELTIATKSTKQ 844


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 600 RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 658
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 595 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 654

Query: 659 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 713
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 655 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 714

Query: 714 EGVDFSKDLLKALYNSIKNEKL 735
            G D  +DLL  +Y  I+  +L
Sbjct: 715 NGEDIPRDLLVGIYQRIQGREL 736


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 600 RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 658
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 800 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 859

Query: 659 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 713
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 860 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 919

Query: 714 EGVDFSKDLLKALYNSIKNEKL 735
            G D  +DLL  +Y  I+  +L
Sbjct: 920 NGEDIPRDLLVGIYQRIQGREL 941


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 8/149 (5%)

Query: 744  KKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKK 803
            ++  P E  E   +       ++ GS   P    P  P   V   GFL RK   D + K 
Sbjct: 2382 RRPRPREGGEGGGSRRSRSAPAQGGSAPAP----PPPPTHTVQHEGFLLRKRELDANRKS 2437

Query: 804  TPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPN 863
            +    R W + Y VL    L   KD   P    S    +  +S+H A +  A+DY+KK +
Sbjct: 2438 S---NRSWVSLYCVLSKGELGFYKDSKGPASG-STHGGEPLLSLHKATSEVASDYKKKKH 2493

Query: 864  VFKLKTADWRVLLFQTQSPEEMQGWINKI 892
            VFKL+T D    L Q +  EEM GW+  +
Sbjct: 2494 VFKLQTQDGSEFLLQAKDEEEMNGWLEAV 2522


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 15/190 (7%)

Query: 743  EKKKSPSESTEEKANGTHPKTISRIGSTTNPFL-DIPH---DPNAAVYKSGFLARKIHAD 798
            ++   P    + +  G  P  + +  ST +     +P    +P+A     G L RK   +
Sbjct: 2173 DEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEME 2232

Query: 799  MDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDY 858
              GKK     R W+  Y VL+   L   KD  K   A      +  VS+  A  S A DY
Sbjct: 2233 AFGKKA--ANRSWQNVYCVLRRGSLGFYKDA-KAASAGVPYHGEVPVSLARAQGSVAFDY 2289

Query: 859  EKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPL 918
             K+ +VFKL   D +  LFQ +   EM  W+  +N   A  S     +A G  ++   P+
Sbjct: 2290 RKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATAS-----SASGEPEE---PV 2341

Query: 919  LPATTTKLSQ 928
            +P+TT  +++
Sbjct: 2342 VPSTTRGMTR 2351


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 3/119 (2%)

Query: 775  LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK 834
            L  P D   +V   G+L RK   D++G       R W   Y VL+ + L   KD      
Sbjct: 2169 LPAPRDHGQSVQMEGYLGRK--HDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKNLAL 2226

Query: 835  ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 893
             +     +  +++ HA+   A +Y+KK +VFKL+ ++    LF  +  EEM  W+  ++
Sbjct: 2227 GMPYHG-EEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGVS 2284


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 61/237 (25%), Positives = 97/237 (40%), Gaps = 34/237 (14%)

Query: 732  NEKLEWAVDDEEKKKSPSESTEEKANGTHP-KTISRIGSTTNPFLDIPHDPNAAVYKSGF 790
            N   E     +E    PS +++ KA    P ++ + + + T         P+A +   GF
Sbjct: 2152 NGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQ------ETPSAQM--EGF 2203

Query: 791  LARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHA 850
            L RK   +   KK     R W   Y V+    +   KD       +     +  VS+  A
Sbjct: 2204 LNRKHEWEAHNKKA--SSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHS-EVPVSLKEA 2260

Query: 851  LASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGS 910
            +   A DY+KK +VFKL+  D    LFQ +  EEM  WI  I+            +AI S
Sbjct: 2261 VCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAIS------------SAISS 2308

Query: 911  QKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYK 967
             K      + A+T       + ++  + +  IT+E +      P K+ K K+ D+ K
Sbjct: 2309 DKH----EVSASTQSTPASSRAQTLPTSVVTITSESS------PGKREKDKEKDKEK 2355


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 37/115 (32%), Positives = 53/115 (46%), Gaps = 7/115 (6%)

Query: 785 VYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSE------ 838
           + + G+L  K      GKK   G R WK  YA L+   L L K+  +P  A +       
Sbjct: 595 IRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA 654

Query: 839 -EDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKI 892
            ED    V +   L   +    K+ +VF+L TAD+   LFQ +  ++M GWI  I
Sbjct: 655 GEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAI 709


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 37/106 (34%), Positives = 54/106 (50%), Gaps = 4/106 (3%)

Query: 787  KSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVS 846
            K G+L  +      GK+     R WK  Y VL+G  LYL KD+ + +   SEE+    +S
Sbjct: 934  KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDK-REQTTPSEEE--QPIS 990

Query: 847  VHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKI 892
            V+  L   +    K+ NVF+L T+D    LFQ +  ++M  WI  I
Sbjct: 991  VNACLIDISYSETKRKNVFRLTTSDCE-CLFQAEDRDDMLAWIKTI 1035


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 36/119 (30%), Positives = 63/119 (52%), Gaps = 7/119 (5%)

Query: 617 VAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQER-ERVLIHFSNRYFYCNPDTIA--- 672
           V ++ +   +F    L  +LR FF+      E  E  E ++  FS+R+  CNPD +    
Sbjct: 195 VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELG 254

Query: 673 -SQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSI 730
            S D V+ L  +++LL+ DL   ++  KM+ +EFI N +   + +  S+D +  LY++I
Sbjct: 255 LSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNI--SEDFVGHLYDNI 311


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo
           sapiens]
          Length = 1591

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 70/302 (23%), Positives = 129/302 (42%), Gaps = 43/302 (14%)

Query: 701 TCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTH 760
           T + F+ +  G +   D ++   + +Y + + E      + E  +++ S  ++E+++GT 
Sbjct: 361 TGRAFVGSDSGSSSTGDAAR---QGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGT- 416

Query: 761 PKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARK---IHADMDGKKTPRGKRGWKTFYAV 817
              +S  G +      +       V K+G LA K   +H   + K     +R WK ++  
Sbjct: 417 ---LSSPGQSDI----LLTAAQGTVRKAGALAVKNFLVHKK-NKKVESATRRKWKHYWVS 468

Query: 818 LKGTVLYLQKDEYKPEKALSEEDL-KNAVSVHHALASKATDYEKKPNVFKLKTADWRVLL 876
           LKG  L+  + + +    +    + K+AV V +++     ++ KK  VF L  +     L
Sbjct: 469 LKGCTLFFYESDGR--SGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFL 526

Query: 877 FQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ-----EEQ 931
           FQT S  E++ WI       A+ SA     A    K+ +  LL +   KL Q     E+ 
Sbjct: 527 FQTTSQTELENWI------TAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKM 580

Query: 932 LKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLE---FEKTRYEMYVSILK 988
            K  E +L  +T           D K K   +D+  + +  LE    +  R+  Y++ L+
Sbjct: 581 KKMGEMQLSSVT-----------DSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQ 629

Query: 989 EG 990
            G
Sbjct: 630 GG 631


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
           [Homo sapiens]
          Length = 1701

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 49/208 (23%), Positives = 85/208 (40%), Gaps = 12/208 (5%)

Query: 785 VYKSGFLARK--IHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLK 842
           V K+G+L  K  +    + K     +R WK ++  LKG  L L  + Y           +
Sbjct: 507 VRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTL-LFYETYGKNSMDQSSAPR 565

Query: 843 NAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAP 902
            A+    ++     ++ KK NVF L  +   V LFQ  S  +++ W      V AV SA 
Sbjct: 566 CALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENW------VTAVHSAC 619

Query: 903 PFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKD 962
               A    K+ +  LL   T  L Q+  + S   K+ ++   +    S P ++K     
Sbjct: 620 ASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVV---SDPKNRKAIENQ 676

Query: 963 VDEYKLKDHYLEFEKTRYEMYVSILKEG 990
           + +++        +  R   Y++ L+ G
Sbjct: 677 IQQWEQNLEKFHMDLFRMRCYLASLQGG 704


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 48/190 (25%), Positives = 75/190 (39%), Gaps = 19/190 (10%)

Query: 748 PSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRG 807
           P E    +A  T  K ++  G  ++    +  +PNA V K+G+L          K+   G
Sbjct: 27  PPERPSVRATRTARKAVA-FGKRSH---SMKRNPNAPVTKAGWLF---------KQASSG 73

Query: 808 KRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL 867
            + W   + VL    L+  KDE K E  L    L +        A + +D   + + FK 
Sbjct: 74  VKQWNKRWFVLVDRCLFYYKDE-KEESILGSIPLLS----FRVAAVQPSDNISRKHTFKA 128

Query: 868 KTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLS 927
           + A  R   F  +SPEE + WI  +   A V   PP   ++    + S     +     S
Sbjct: 129 EHAGVRTYFFSAESPEEQEAWIQAMGEAARV-QIPPAQKSVPQAVRHSHEKPDSENVPPS 187

Query: 928 QEEQLKSHES 937
           +  Q   H S
Sbjct: 188 KHHQQPPHNS 197


>gi|20149626 pleckstrin homology domain containing, family O member
           1 [Homo sapiens]
          Length = 409

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 34/94 (36%), Positives = 45/94 (47%), Gaps = 17/94 (18%)

Query: 811 WKTFYAVLKGTVLYLQKDEYKPEKALSE----------EDLKNAVSVHHALASKAT-DYE 859
           WK  Y VLKG  LY+ + E K EK + E          E+L+ + S      SK T  + 
Sbjct: 41  WKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHS 100

Query: 860 KKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 893
           K+P      TA    L+F   SPEE + WIN +N
Sbjct: 101 KQPG----NTAP--NLIFLAVSPEEKESWINALN 128


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,833,874
Number of Sequences: 37866
Number of extensions: 2039743
Number of successful extensions: 7106
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 6855
Number of HSP's gapped (non-prelim): 321
length of query: 1047
length of database: 18,247,518
effective HSP length: 113
effective length of query: 934
effective length of database: 13,968,660
effective search space: 13046728440
effective search space used: 13046728440
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.