BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|117320537 phospholipase C, gamma 2 [Homo sapiens] (1265 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 2576 0.0 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 1233 0.0 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 1231 0.0 gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 241 4e-63 gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 241 4e-63 gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 235 2e-61 gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 235 2e-61 gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 235 2e-61 gi|78499633 phospholipase C, eta 2 [Homo sapiens] 231 3e-60 gi|19115964 phospholipase C delta 3 [Homo sapiens] 230 7e-60 gi|14249340 phospholipase C, delta 4 [Homo sapiens] 219 2e-56 gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 213 1e-54 gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 213 1e-54 gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 199 1e-50 gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 199 1e-50 gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 187 4e-47 gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 173 1e-42 gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 173 1e-42 gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 172 2e-42 gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 157 5e-38 gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 157 5e-38 gi|11386139 phospholipase C beta 3 [Homo sapiens] 153 9e-37 gi|95147333 phospholipase C, beta 2 [Homo sapiens] 150 6e-36 gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 86 3e-16 gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 82 3e-15 gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 82 3e-15 gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 77 8e-14 gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 75 3e-13 gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 74 7e-13 gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 70 1e-11 >gi|117320537 phospholipase C, gamma 2 [Homo sapiens] Length = 1265 Score = 2576 bits (6678), Expect = 0.0 Identities = 1265/1265 (100%), Positives = 1265/1265 (100%) Query: 1 MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK 60 MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK Sbjct: 1 MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK 60 Query: 61 IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV 120 IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV Sbjct: 61 IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV 120 Query: 121 NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA 180 NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA Sbjct: 121 NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA 180 Query: 181 KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA 240 KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA Sbjct: 181 KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA 240 Query: 241 VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS 300 VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS Sbjct: 241 VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS 300 Query: 301 IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC 360 IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC Sbjct: 301 IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC 360 Query: 361 WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA 420 WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA Sbjct: 361 WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA 420 Query: 421 FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE 480 FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE Sbjct: 421 FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE 480 Query: 481 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR 540 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR Sbjct: 481 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR 540 Query: 541 TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY 600 TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY Sbjct: 541 TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY 600 Query: 601 LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML 660 LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML Sbjct: 601 LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML 660 Query: 661 MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY 720 MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY Sbjct: 661 MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY 720 Query: 721 EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY 780 EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY Sbjct: 721 EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY 780 Query: 781 KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII 840 KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII Sbjct: 781 KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII 840 Query: 841 EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF 900 EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF Sbjct: 841 EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF 900 Query: 901 QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE 960 QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE Sbjct: 901 QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE 960 Query: 961 TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY 1020 TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY Sbjct: 961 TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY 1020 Query: 1021 MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI 1080 MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI Sbjct: 1021 MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI 1080 Query: 1081 ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED 1140 ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED Sbjct: 1081 ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED 1140 Query: 1141 MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC 1200 MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC Sbjct: 1141 MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC 1200 Query: 1201 RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN 1260 RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN Sbjct: 1201 RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN 1260 Query: 1261 SKFYS 1265 SKFYS Sbjct: 1261 SKFYS 1265 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 1233 bits (3190), Expect = 0.0 Identities = 645/1278 (50%), Positives = 866/1278 (67%), Gaps = 39/1278 (3%) Query: 11 AEYEKSQIKRALELGTVMTVFSFRKST-PERRTVQVIMETRQVAWSKTADKIEGFLDIME 69 ++ E + R+LE+GTVMT+F +KS PER+T QV +ETRQ+ WS+ ADKIEG +DI E Sbjct: 18 SDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIRE 77 Query: 70 IKEIRPGKNSKDFERAK---AVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 IKEIRPGK S+DF+R + A R + CF ILYG +F L TLSL A S+++ W+ GL Sbjct: 78 IKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGL 137 Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186 L ++ + A TP IE WLRKQ YSVD+ R + IS ++LK +L +N++V + +FL+++ Sbjct: 138 TWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRER 197 Query: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246 ++ ++++ QF Y+ LM+ QK++ F + S+ L +RP+ V L +F Sbjct: 198 LTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEAST---LRAGERPELCRVSLPEF 254 Query: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306 Q+FL+ Q E WA D +V+E M F+ D +RE EP+ F+DEF+T+LFS+ENS+W+ + Sbjct: 255 QQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQL 314 Query: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366 DAV MNNPLSHYWISSSHNTYLTGDQ SESS EAY RCLRMGCRCIELDCWDGPDG Sbjct: 315 DAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG 374 Query: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426 PVIYHG T TTKIKF DV+ IK+HAFV S +PVILSIE+HCS+ QQR+MA+ FK+V G Sbjct: 375 MPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLG 434 Query: 427 DLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRG---DVDVNM---EDKKDEHKQQGE 480 D LLTKP E SAD LPSP+QL+ KI+IKHKKL +V +M E+ + G Sbjct: 435 DTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGI 494 Query: 481 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTM---EEEVPQDI-PPTELHFGEKWFHKK 536 LY+ D ++ +W HY + +K+ +S++ +EE P+++ TELH EKWFH K Sbjct: 495 LYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGK 554 Query: 537 V----EKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592 + + R AE+LL EYC+ETG DG+FLVRESETF DYTLSFWR+G+VQHCRI S Sbjct: 555 LGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQ 614 Query: 593 EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLS 652 + GT K++LTDNL F S+Y LI HY++ LRC EFE+RL++PVP N HESK WY+ SL+ Sbjct: 615 DAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLT 674 Query: 653 RGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES 712 R +AE MLMR+PRDGAFL+RKR +SYAI+FRA GK+KHCR+ ++G+ +LG S F+S Sbjct: 675 RAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSE-FDS 733 Query: 713 LVELVSYYEKHSLYRKMRLRYPVTPELLERY-NMERDINSLYDVSR--MYVDPSEINPSM 769 LV+L+SYYEKH LYRKM+LRYP+ E LE+ E D +LY+ YV E NP M Sbjct: 734 LVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYV---EANP-M 789 Query: 770 P--QRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDI 827 P + VKAL+DYKA+R DEL+F + A+I NV K+ GGWW+GDYG + Q +FPSNYVE++ Sbjct: 790 PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEM 849 Query: 828 STADFEELEKQIIEDN-PLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPV 886 E E++ +++N PLG L RG+LD+ + P+GKN + FVF + + Sbjct: 850 VNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSL 909 Query: 887 EFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPT--SKTK 944 + A D EEL +W + IRE+ D + K E+ + IA+ELS+LVVYC+P + K Sbjct: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969 Query: 945 DNLENPDFREIRSFVETKADSII-RQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLW 1003 E +R++ SF ETKA+ + + K L+YN+ L+R+YPKGQR+DSSNYDP +W Sbjct: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029 Query: 1004 LCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKI-LMT 1062 +CGSQ+VALNFQT DK MQMN ALF GYVLQP +MR E +DP S R + Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCA 1089 Query: 1063 LTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTF 1122 ++++VLGARHLPK GR I CPFVE+E+ GAEYD+ K KT V DNGL+P+W + F Sbjct: 1090 ISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW--PAKPFHF 1147 Query: 1123 EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 +I +P AFLRFVVYEEDMFSD NFLA AT+P+K +K+G+R+VPLKN YSED+ELASLL+ Sbjct: 1148 QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207 Query: 1183 FCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQL 1242 ++ P E+ + S LR R + + QLF + + ++F +++ L Sbjct: 1208 KIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHL 1267 Query: 1243 QLYQEKCNKRL-REKRVS 1259 + + +R R RV+ Sbjct: 1268 ADHFDSRERRAPRRTRVN 1285 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 1231 bits (3185), Expect = 0.0 Identities = 645/1279 (50%), Positives = 866/1279 (67%), Gaps = 40/1279 (3%) Query: 11 AEYEKSQIKRALELGTVMTVFSFRKST-PERRTVQVIMETRQVAWSKTADKIEGFLDIME 69 ++ E + R+LE+GTVMT+F +KS PER+T QV +ETRQ+ WS+ ADKIEG +DI E Sbjct: 18 SDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIRE 77 Query: 70 IKEIRPGKNSKDFERAK---AVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 IKEIRPGK S+DF+R + A R + CF ILYG +F L TLSL A S+++ W+ GL Sbjct: 78 IKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGL 137 Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186 L ++ + A TP IE WLRKQ YSVD+ R + IS ++LK +L +N++V + +FL+++ Sbjct: 138 TWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRER 197 Query: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246 ++ ++++ QF Y+ LM+ QK++ F + S+ L +RP+ V L +F Sbjct: 198 LTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEAST---LRAGERPELCRVSLPEF 254 Query: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306 Q+FL+ Q E WA D +V+E M F+ D +RE EP+ F+DEF+T+LFS+ENS+W+ + Sbjct: 255 QQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQL 314 Query: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366 DAV MNNPLSHYWISSSHNTYLTGDQ SESS EAY RCLRMGCRCIELDCWDGPDG Sbjct: 315 DAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG 374 Query: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426 PVIYHG T TTKIKF DV+ IK+HAFV S +PVILSIE+HCS+ QQR+MA+ FK+V G Sbjct: 375 MPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLG 434 Query: 427 DLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRG---DVDVNM---EDKKDEHKQQGE 480 D LLTKP E SAD LPSP+QL+ KI+IKHKKL +V +M E+ + G Sbjct: 435 DTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGI 494 Query: 481 LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTM---EEEVPQDI-PPTELHFGEKWFHKK 536 LY+ D ++ +W HY + +K+ +S++ +EE P+++ TELH EKWFH K Sbjct: 495 LYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGK 554 Query: 537 V----EKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592 + + R AE+LL EYC+ETG DG+FLVRESETF DYTLSFWR+G+VQHCRI S Sbjct: 555 LGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQ 614 Query: 593 EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLS 652 + GT K++LTDNL F S+Y LI HY++ LRC EFE+RL++PVP N HESK WY+ SL+ Sbjct: 615 DAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLT 674 Query: 653 RGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES 712 R +AE MLMR+PRDGAFL+RKR +SYAI+FRA GK+KHCR+ ++G+ +LG S F+S Sbjct: 675 RAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSE-FDS 733 Query: 713 LVELVSYYEKHSLYRKMRLRYPVTPELLERY-NMERDINSLYDVSR--MYVDPSEINPSM 769 LV+L+SYYEKH LYRKM+LRYP+ E LE+ E D +LY+ YV E NP M Sbjct: 734 LVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYV---EANP-M 789 Query: 770 P--QRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDI 827 P + VKAL+DYKA+R DEL+F + A+I NV K+ GGWW+GDYG + Q +FPSNYVE++ Sbjct: 790 PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEM 849 Query: 828 STADFEELEKQIIEDN-PLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPV 886 E E++ +++N PLG L RG+LD+ + P+GKN + FVF + + Sbjct: 850 VNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSL 909 Query: 887 EFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPT--SKTK 944 + A D EEL +W + IRE+ D + K E+ + IA+ELS+LVVYC+P + K Sbjct: 910 DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969 Query: 945 DNLENPDFREIRSFVETKADSII-RQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLW 1003 E +R++ SF ETKA+ + + K L+YN+ L+R+YPKGQR+DSSNYDP +W Sbjct: 970 IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029 Query: 1004 LCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKI-LMT 1062 +CGSQ+VALNFQT DK MQMN ALF GYVLQP +MR E +DP S R + Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCA 1089 Query: 1063 LTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTF 1122 ++++VLGARHLPK GR I CPFVE+E+ GAEYD+ K KT V DNGL+P+W + F Sbjct: 1090 ISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW--PAKPFHF 1147 Query: 1123 EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 +I +P AFLRFVVYEEDMFSD NFLA AT+P+K +K+G+R+VPLKN YSED+ELASLL+ Sbjct: 1148 QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207 Query: 1183 FCEMRPVLESEEELYS-SCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQ 1241 ++ P + +L S LR R + + QLF + + ++F +++ Sbjct: 1208 KIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEH 1267 Query: 1242 LQLYQEKCNKRL-REKRVS 1259 L + + +R R RV+ Sbjct: 1268 LADHFDSRERRAPRRTRVN 1286 >gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] Length = 756 Score = 241 bits (614), Expect = 4e-63 Identities = 150/395 (37%), Positives = 221/395 (55%), Gaps = 22/395 (5%) Query: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 I +I+E+R G ++ E+ A ED CF+I++ Q +TL L A S DA +W+ GL Sbjct: 69 IEDIQEVRMGHRTEGLEKF-ARDVPEDRCFSIVFKDQ--RNTLDLIAPSPADAQHWVLGL 125 Query: 127 -KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKD 185 KI+H + ++ W+ + D+ + N +S +EL+ L +N +V + + + Sbjct: 126 HKIIHHSG-SMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YARK 183 Query: 186 KFVEIG-AHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLH 244 F E + D L E+ FYK M Q+ I F + + + + Sbjct: 184 IFRECDHSQTDSLEDEEIEAFYK--MLTQRVEIDRTFAEAAG----------SGETLSVD 231 Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304 FL H+Q+E A + + + + + A+ + D FL YL S + S + Sbjct: 232 QLVTFLQHQQREEAAGPALALS--LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSL 289 Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364 + V QDM PLSHY +SSSHNTYL DQL SS EAYIR L GCRC+ELDCWDGP Sbjct: 290 AHRRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGP 348 Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424 + +P+IYHG+T T+KI F DV++AI+D+AF S +PVILS+E HC++EQQR MA+ + Sbjct: 349 NQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAI 408 Query: 425 FGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLG 459 G +LL +P + + LPSP QL+ KI++K KKLG Sbjct: 409 LGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLG 443 Score = 147 bits (372), Expect = 5e-35 Identities = 101/321 (31%), Positives = 159/321 (49%), Gaps = 28/321 (8%) Query: 875 ILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLV 934 +L P +G P +D E +++R + KE+ ++ +A ELSD+V Sbjct: 445 LLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRV-QHKPKEDKLR-------LAQELSDMV 496 Query: 935 VYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQR 991 +YCK + F E+ SF E +A ++++ +++N L+R+YP G R Sbjct: 497 IYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWR 556 Query: 992 VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPM 1051 DSSNY P +W G Q+VALNFQT M + F NG GYVL+P +R DP Sbjct: 557 TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR----DPN 612 Query: 1052 PPESQRKILM-------TLTVKVLGARHLPKLGR---SIACPFVEVEICGAEYDNNKFKT 1101 + R + L ++V+ + LPK+ + SI P V VEI G D +T Sbjct: 613 GTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQT 672 Query: 1102 TVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSG 1161 V+ +NG +P W + FE+ P+LA +RF+V + D S +F+ +T P+ ++K G Sbjct: 673 AVITNNGFNPWW---DTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 729 Query: 1162 FRSVPLKNGYSEDIELASLLV 1182 +R V L + + A+L V Sbjct: 730 YRHVHLMSKNGDQHPSATLFV 750 >gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] Length = 777 Score = 241 bits (614), Expect = 4e-63 Identities = 150/395 (37%), Positives = 221/395 (55%), Gaps = 22/395 (5%) Query: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 I +I+E+R G ++ E+ A ED CF+I++ Q +TL L A S DA +W+ GL Sbjct: 90 IEDIQEVRMGHRTEGLEKF-ARDVPEDRCFSIVFKDQ--RNTLDLIAPSPADAQHWVLGL 146 Query: 127 -KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKD 185 KI+H + ++ W+ + D+ + N +S +EL+ L +N +V + + + Sbjct: 147 HKIIHHSG-SMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YARK 204 Query: 186 KFVEIG-AHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLH 244 F E + D L E+ FYK M Q+ I F + + + + Sbjct: 205 IFRECDHSQTDSLEDEEIEAFYK--MLTQRVEIDRTFAEAAG----------SGETLSVD 252 Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304 FL H+Q+E A + + + + + A+ + D FL YL S + S + Sbjct: 253 QLVTFLQHQQREEAAGPALALS--LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSL 310 Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364 + V QDM PLSHY +SSSHNTYL DQL SS EAYIR L GCRC+ELDCWDGP Sbjct: 311 AHRRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGP 369 Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424 + +P+IYHG+T T+KI F DV++AI+D+AF S +PVILS+E HC++EQQR MA+ + Sbjct: 370 NQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAI 429 Query: 425 FGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLG 459 G +LL +P + + LPSP QL+ KI++K KKLG Sbjct: 430 LGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLG 464 Score = 147 bits (372), Expect = 5e-35 Identities = 101/321 (31%), Positives = 159/321 (49%), Gaps = 28/321 (8%) Query: 875 ILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLV 934 +L P +G P +D E +++R + KE+ ++ +A ELSD+V Sbjct: 466 LLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRV-QHKPKEDKLR-------LAQELSDMV 517 Query: 935 VYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQR 991 +YCK + F E+ SF E +A ++++ +++N L+R+YP G R Sbjct: 518 IYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWR 577 Query: 992 VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPM 1051 DSSNY P +W G Q+VALNFQT M + F NG GYVL+P +R DP Sbjct: 578 TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR----DPN 633 Query: 1052 PPESQRKILM-------TLTVKVLGARHLPKLGR---SIACPFVEVEICGAEYDNNKFKT 1101 + R + L ++V+ + LPK+ + SI P V VEI G D +T Sbjct: 634 GTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQT 693 Query: 1102 TVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSG 1161 V+ +NG +P W + FE+ P+LA +RF+V + D S +F+ +T P+ ++K G Sbjct: 694 AVITNNGFNPWW---DTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750 Query: 1162 FRSVPLKNGYSEDIELASLLV 1182 +R V L + + A+L V Sbjct: 751 YRHVHLMSKNGDQHPSATLFV 771 >gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] Length = 1002 Score = 235 bits (599), Expect = 2e-61 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%) Query: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114 S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L Sbjct: 56 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111 Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 + E+A W++GLK L E A + W+++ D+ +++ E+ ++ Sbjct: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171 Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228 +N + K ++ F E +++ L+FE+F +FYK + ++D + Sbjct: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220 Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284 +L +D+ D H E AQ L KV ++M D + + F Sbjct: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265 Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337 L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL Sbjct: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324 Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397 S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV + Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384 Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456 FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K Sbjct: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444 Query: 457 KL-----GPRGDVDVNMEDKKDE 474 KL + +V+ ED DE Sbjct: 445 KLPYHLGDDAEEGEVSDEDSADE 467 Score = 169 bits (427), Expect = 2e-41 Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%) Query: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981 K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK Sbjct: 593 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651 Query: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041 LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+ Sbjct: 652 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711 Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089 M + DP+P ++++++ KV+ + LPK S I PFVEVEI Sbjct: 712 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767 Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+ Sbjct: 768 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823 Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 T ++ G+R V Y E + AS+ V Sbjct: 824 QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851 >gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] Length = 1693 Score = 235 bits (599), Expect = 2e-61 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%) Query: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114 S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L Sbjct: 56 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111 Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 + E+A W++GLK L E A + W+++ D+ +++ E+ ++ Sbjct: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171 Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228 +N + K ++ F E +++ L+FE+F +FYK + ++D + Sbjct: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220 Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284 +L +D+ D H E AQ L KV ++M D + + F Sbjct: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265 Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337 L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL Sbjct: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324 Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397 S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV + Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384 Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456 FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K Sbjct: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444 Query: 457 KL-----GPRGDVDVNMEDKKDE 474 KL + +V+ ED DE Sbjct: 445 KLPYHLGDDAEEGEVSDEDSADE 467 Score = 169 bits (427), Expect = 2e-41 Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%) Query: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981 K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK Sbjct: 593 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651 Query: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041 LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+ Sbjct: 652 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711 Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089 M + DP+P ++++++ KV+ + LPK S I PFVEVEI Sbjct: 712 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767 Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+ Sbjct: 768 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823 Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 T ++ G+R V Y E + AS+ V Sbjct: 824 QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851 >gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] Length = 1655 Score = 235 bits (599), Expect = 2e-61 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%) Query: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114 S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L Sbjct: 38 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 93 Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 + E+A W++GLK L E A + W+++ D+ +++ E+ ++ Sbjct: 94 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 153 Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228 +N + K ++ F E +++ L+FE+F +FYK + ++D + Sbjct: 154 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 202 Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284 +L +D+ D H E AQ L KV ++M D + + F Sbjct: 203 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 247 Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337 L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL Sbjct: 248 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 306 Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397 S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV + Sbjct: 307 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 366 Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456 FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K Sbjct: 367 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 426 Query: 457 KL-----GPRGDVDVNMEDKKDE 474 KL + +V+ ED DE Sbjct: 427 KLPYHLGDDAEEGEVSDEDSADE 449 Score = 171 bits (433), Expect = 4e-42 Identities = 105/295 (35%), Positives = 161/295 (54%), Gaps = 33/295 (11%) Query: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981 K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK Sbjct: 575 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 633 Query: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041 LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+ Sbjct: 634 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 693 Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089 M + DP+P ++++++ KV+ + LPK S I PFVEVEI Sbjct: 694 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 749 Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+ Sbjct: 750 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 805 Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLR 1204 T ++ G+R V Y E + AS+ V + E+Y RQL+ Sbjct: 806 QRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI-------NEIYGKNRQLQ 848 >gi|78499633 phospholipase C, eta 2 [Homo sapiens] Length = 1416 Score = 231 bits (590), Expect = 3e-60 Identities = 146/430 (33%), Positives = 228/430 (53%), Gaps = 25/430 (5%) Query: 52 VAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSL 111 + W + + + I I+E+ G+ S+ F+R +CCF+I +G+ +L L Sbjct: 78 IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSH--RESLDL 135 Query: 112 AADSKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELK 167 + S E A W++GL+ L E A + WL++ D+ S+S+ E+ Sbjct: 136 VSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVL 195 Query: 168 TILPLINFKVSSAKFLKDKFVEIGA--HKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225 +L +N + + +K F E H+ L FE+F FYK + + +L Sbjct: 196 QLLHKLNVNLPRQR-VKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLL------- 247 Query: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFL 285 + + D DA+++ QRFL EQ+ L ++ + +F + ++ L Sbjct: 248 MLTYSNHKDHLDAASL-----QRFLQVEQKMAGVT-LESCQDIIEQF-EPCPENKSKGLL 300 Query: 286 FVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345 +D F Y S I++ ++ V QDM PLSHY+I+SSHNTYL GDQL S+S + Y Sbjct: 301 GIDGFTNYTRSPAGDIFNPEHHHVH-QDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359 Query: 346 IRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSI 405 L+ GCRC+E+DCWDGPDG+P+++HG+T T+KI F DV++ I +AF+ + +PVILSI Sbjct: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419 Query: 406 EEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDV 464 E HCSV QQ+ MA+ ++ GD L L+ + A LPSP L+ KI++K KKL Sbjct: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479 Query: 465 DVNMEDKKDE 474 D + DE Sbjct: 480 DAEEGEVSDE 489 Score = 169 bits (429), Expect = 1e-41 Identities = 102/274 (37%), Positives = 154/274 (56%), Gaps = 25/274 (9%) Query: 921 EKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQK 980 +K ++ LSDLV Y K + +E ++ SF ETKA I++QKP L++NQ+ Sbjct: 617 KKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQ 676 Query: 981 GLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQP 1040 L+R+YP RVDSSNY+P W G QMVALN+Q+ + +Q+N A FS NG GYVL+P Sbjct: 677 QLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKP 736 Query: 1041 ESM-----RTEKYDPMPPESQRKILMTLTVKVLGARHLPK-----LG--RSIACPFVEVE 1088 M DP+P + +++ L ++++ + LPK LG I PFVEVE Sbjct: 737 GCMCQGVFNPNSEDPLPGQLKKQ----LVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVE 792 Query: 1089 ICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFL 1148 I G D ++ +T VV+DNG +P W +E + F ++ P +A +RF+V++ D +F+ Sbjct: 793 IIGLPVDCSREQTRVVDDNGFNPTW---EETLVFMVHMPEIALVRFLVWDHDPIG-RDFI 848 Query: 1149 AHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 T ++ G+R V Y E +E AS+ V Sbjct: 849 GQRTLAFSSMMPGYRHV-----YLEGMEEASIFV 877 >gi|19115964 phospholipase C delta 3 [Homo sapiens] Length = 789 Score = 230 bits (586), Expect = 7e-60 Identities = 139/418 (33%), Positives = 224/418 (53%), Gaps = 25/418 (5%) Query: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 + I+ +R G S+ R C G + L LAA + E+A W+ GL Sbjct: 111 VQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRR---KNLDLAAPTAEEAQRWVRGL 167 Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA-KFLKD 185 L S ++ W+ ++ D + + +S +E+K++L ++N ++ +L Sbjct: 168 TKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLF 227 Query: 186 KFVEIGAHKDELSFEQFHLFYKKLMFEQQ-KSILDEFKKDSSVFILGNTDRPDASAVYLH 244 K + ++ D L + F ++L+ + + I ++ + V SA L Sbjct: 228 KECD-HSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVL----------SAPELL 276 Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304 +F + +Q E A + T +++T ++ + +D F+ YL S E + D Sbjct: 277 EF----LEDQGEEGATLARAQQLIQTYELNETAKQ--HELMTLDGFMMYLLSPEGAALDN 330 Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364 + V QDMN PL+HY+ISSSHNTYLT Q+ SS EAY+R GCRC+ELDCW+GP Sbjct: 331 THTCV-FQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGP 389 Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424 G+PVIYHG T T+KI F DVVQA++DHAF S +PVILS+E HC +EQQ MA+ + Sbjct: 390 GGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTI 449 Query: 425 FGDLLLTKPTEA-SADQLPSPSQLREKIIIKHKKL-GPRGDVDVNMEDKKDEHKQQGE 480 GD+L+T+ ++ + ++LPSP QL+ ++++K KKL R + + D+++E + E Sbjct: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEE 507 Score = 155 bits (391), Expect = 3e-37 Identities = 99/267 (37%), Positives = 146/267 (54%), Gaps = 14/267 (5%) Query: 924 QSIAIELSDLVVYCKPTS-KTKDNLEN-PDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981 + I+ ELS L VYC T +T N P ++ S E KA +IR+ +++N + Sbjct: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581 Query: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041 LTRVYP G R++S+NY P +W G Q+VALNFQT M +N F +NG+ GYVL+P Sbjct: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641 Query: 1042 SMR--TEKYDPMPPESQRKILMTLTVKVLGARHLPKLG----RSIACPFVEVEICGAEYD 1095 +R +DP P R TL+++VL A+ LPKL SI P V +EI G D Sbjct: 642 CLRQPDSTFDPEYPGPPR---TTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPAD 698 Query: 1096 NNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPI 1155 + +T V +NG +P W T + F++ P LA +RFVV + D S +F+ T P+ Sbjct: 699 CARQETDYVLNNGFNPRWGQT---LQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPL 755 Query: 1156 KAVKSGFRSVPLKNGYSEDIELASLLV 1182 ++K G+R + L + + A+L + Sbjct: 756 SSLKQGYRHIHLLSKDGASLSPATLFI 782 >gi|14249340 phospholipase C, delta 4 [Homo sapiens] Length = 762 Score = 219 bits (557), Expect = 2e-56 Identities = 142/409 (34%), Positives = 217/409 (53%), Gaps = 19/409 (4%) Query: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126 I +++ IR G +S + R+ A + FTI++ + S L L A+S E+A W+ GL Sbjct: 63 ISDVETIRNGHDS-ELLRSLAEELPLEQGFTIVFHGR--RSNLDLMANSVEEAQIWMRGL 119 Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186 ++L + ++ WL D+ + +S +E++ +L L+N ++ Sbjct: 120 QLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLF 179 Query: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246 + L E+F FYK L K + V L + D + L +F Sbjct: 180 QAADTSQSGTLEGEEFVQFYKALT------------KRAEVQELFESFSADGQKLTLLEF 227 Query: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306 FL EQ+E +++ + + + L +D FL+YL S++ I++ Sbjct: 228 LDFLQEEQKER--DCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPAC 285 Query: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366 + QDM PL+HY+I SSHNTYL GDQL +SS E YIR L+ GCRC+E+D WDGP G Sbjct: 286 LPI-YQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG 344 Query: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426 +PV+YHG T T++I F DVV + +AF TS +PVILS+E HCS EQQ+ MA+ E+ G Sbjct: 345 EPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILG 404 Query: 427 DLLLTKPTE-ASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDE 474 + LL+ + QLPSP +LR KI++K KKL D++ E+ + E Sbjct: 405 EQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPE 453 Score = 160 bits (405), Expect = 7e-39 Identities = 109/324 (33%), Positives = 166/324 (51%), Gaps = 17/324 (5%) Query: 879 KQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCK 938 +++ +P +E + +E FE +E +N K + + LS LV+Y K Sbjct: 447 EEEAEPELEESELALESQFETEPEPQE-----QNLQNKDKKKKSKPILCPALSSLVIYLK 501 Query: 939 PTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSN 996 S + E+ F EI SF ETKA +I++ + +++N L+RVYP G R DSSN Sbjct: 502 SVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSN 561 Query: 997 YDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--TEKYDPMPPE 1054 Y+P LW G QMVA+N QTA M + F NG GYVL+P+ +R + P P Sbjct: 562 YNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPI 621 Query: 1055 SQRKILMTLTVKVLGARHLPKLGR----SIACPFVEVEICGAEYDNNKFKTTVVNDNGLS 1110 S K TL ++V+ + LPK+ + SI P V+V+I G D + +T V +NG + Sbjct: 622 SPFK-AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFN 680 Query: 1111 PIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNG 1170 P W T + F + P LA LRFVV + D S +F+ T P ++ G+R + L + Sbjct: 681 PYWGQT---LCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSK 737 Query: 1171 YSEDIELASLLVFCEMRPVLESEE 1194 + AS+ V+ ++ LE +E Sbjct: 738 DGISLRPASIFVYICIQEGLEGDE 761 >gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] Length = 1127 Score = 213 bits (541), Expect = 1e-54 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%) Query: 59 DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116 D + +DI IKE+R GKN+ D R+ + + EDC F+++YG + +L L A+S Sbjct: 180 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 236 Query: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 + A W++GL+ L + + +S + SW+ + +D I+L + Sbjct: 237 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 296 Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215 +N + ++K ++ KF E+ KD+ E FH +++ + F K Sbjct: 297 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 355 Query: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275 LD KD +F+ + ++ + H +E + ++K + Sbjct: 356 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 390 Query: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335 + + +L +D F YL S + I+D ++ V QDM PLSHY+I+SSHNTYL DQ Sbjct: 391 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 449 Query: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395 R S YIR L+MGCR +ELD WDGPD +PVIY G T T++I F V+ I +AF Sbjct: 450 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 509 Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455 S +P+IL +E HCS++QQ+ M + K++ GD L T LPSP L+ KI+IK Sbjct: 510 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 569 Query: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478 KKL + DV ED+ E Q+ Sbjct: 570 KKLSSNCSGVEGDVTDEDEGAEMSQR 595 Score = 144 bits (362), Expect = 7e-34 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%) Query: 922 KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979 K + ELS+LV CK + + + + + E+ SF E A + P D + YN+ Sbjct: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 669 Query: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039 + L RV+P R+DSSN +P W CG Q+VA+NFQT M +N F NG GYVL+ Sbjct: 670 RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 729 Query: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087 P MR E D +P S + L +K++ ++ PK S + P+V V Sbjct: 730 PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785 Query: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147 EI G D + +T V+ NG +PI+ E F+I P LA +RFVV ++D D F Sbjct: 786 EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 841 Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 + T P + +++G+R VPL++ E + ASL V Sbjct: 842 IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876 >gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] Length = 1001 Score = 213 bits (541), Expect = 1e-54 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%) Query: 59 DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116 D + +DI IKE+R GKN+ D R+ + + EDC F+++YG + +L L A+S Sbjct: 54 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 110 Query: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 + A W++GL+ L + + +S + SW+ + +D I+L + Sbjct: 111 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 170 Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215 +N + ++K ++ KF E+ KD+ E FH +++ + F K Sbjct: 171 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 229 Query: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275 LD KD +F+ + ++ + H +E + ++K + Sbjct: 230 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 264 Query: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335 + + +L +D F YL S + I+D ++ V QDM PLSHY+I+SSHNTYL DQ Sbjct: 265 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 323 Query: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395 R S YIR L+MGCR +ELD WDGPD +PVIY G T T++I F V+ I +AF Sbjct: 324 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 383 Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455 S +P+IL +E HCS++QQ+ M + K++ GD L T LPSP L+ KI+IK Sbjct: 384 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 443 Query: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478 KKL + DV ED+ E Q+ Sbjct: 444 KKLSSNCSGVEGDVTDEDEGAEMSQR 469 Score = 144 bits (362), Expect = 7e-34 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%) Query: 922 KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979 K + ELS+LV CK + + + + + E+ SF E A + P D + YN+ Sbjct: 484 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 543 Query: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039 + L RV+P R+DSSN +P W CG Q+VA+NFQT M +N F NG GYVL+ Sbjct: 544 RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 603 Query: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087 P MR E D +P S + L +K++ ++ PK S + P+V V Sbjct: 604 PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659 Query: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147 EI G D + +T V+ NG +PI+ E F+I P LA +RFVV ++D D F Sbjct: 660 EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 715 Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 + T P + +++G+R VPL++ E + ASL V Sbjct: 716 IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750 >gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] Length = 1095 Score = 199 bits (507), Expect = 1e-50 Identities = 154/457 (33%), Positives = 232/457 (50%), Gaps = 41/457 (8%) Query: 48 ETRQVAWSKTADKIE-GFLDIMEIKEIRPGKNSKDFERAKAVRQK-EDCCFTILYGTQFV 105 + + + W + +E LDI IKEIR GKN++ F Q EDC F+IL+G + Sbjct: 140 DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENY- 198 Query: 106 LSTLSLAADSKEDAVNWLSGLKILHQEAM--------NASTPTIIESWLRKQIYSVDQTR 157 +L L A+S + A W+SGL+ L + N +TP + WL K ++ Sbjct: 199 -ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFM--WL-KTVFEAADVD 254 Query: 158 RNSISLRELKT-ILPLINFKVSSAKFLKDKFVEIGAHKDELSF----EQFHLFYKKLMFE 212 N I L + ++ +N + AK ++ KF EI K++L+ E+F + +L Sbjct: 255 GNGIMLEDTSVELIKQLNPTLKEAK-IRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR 313 Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQ-EHWAQDLNKVRERMTK 271 + L V I N + DA+ D FL EQ H +D+ R + Sbjct: 314 PEVYFL-------LVQISKNKEYLDAN-----DLMLFLEAEQGVTHITEDICLDIIRRYE 361 Query: 272 FIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYL 331 ++ ++ FL +D F YL S E I+D + V QDM PLSHY+I++SHNTYL Sbjct: 362 LSEEGRQKG---FLAIDGFTQYLLSSECDIFDPEQKKV-AQDMTQPLSHYYINASHNTYL 417 Query: 332 TGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKD 391 DQ R + YIR L+MGCR +ELD DG D +P++ + TT + F V++ I Sbjct: 418 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINK 477 Query: 392 HAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKI 451 AFV S +P+IL + HCS+ QQ+ MA+ K+VFG+ L T+ S LPSP +L+ I Sbjct: 478 FAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMI 537 Query: 452 IIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSID 488 I+K KKL DV +E + + ++ E+ S+D Sbjct: 538 IVKGKKLPSDPDV---LEGEVTDEDEEAEMSRRMSVD 571 Score = 145 bits (367), Expect = 2e-34 Identities = 106/333 (31%), Positives = 164/333 (49%), Gaps = 31/333 (9%) Query: 864 PQGKNQKSFVFILEPKQQGDPPV--EFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921 P + K + + K DP V TD EE E++ ++ N + Sbjct: 528 PSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEA--------EMSRRMSVDYNGE---Q 576 Query: 922 KNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979 K + ELSDLV CK L ++ ++ E+ SF ET+A I + P D + YN+ Sbjct: 577 KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNK 636 Query: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039 K L+R+YP R+DSSN +P W CG Q+VA+NFQT M ++ F NG GYVL+ Sbjct: 637 KFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLR 696 Query: 1040 PESMRTEKYDPMPPESQRKIL-----MTLTVKVLGARHLPK-----LGRSIACPFVEVEI 1089 P MR E + + IL + L +K++ ++ PK + P+V +EI Sbjct: 697 PSIMRDEV--SYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 754 Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 G D ++ +T V N +PI+ T E F++ P LA +RFVV ++D D F+ Sbjct: 755 HGIPADCSEQRTKTVQQNSDNPIFDETFE---FQVNLPELAMIRFVVLDDDYIGD-EFIG 810 Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 T P + ++ G+R VPL++ + +E +L V Sbjct: 811 QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 843 >gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] Length = 997 Score = 199 bits (507), Expect = 1e-50 Identities = 154/457 (33%), Positives = 232/457 (50%), Gaps = 41/457 (8%) Query: 48 ETRQVAWSKTADKIE-GFLDIMEIKEIRPGKNSKDFERAKAVRQK-EDCCFTILYGTQFV 105 + + + W + +E LDI IKEIR GKN++ F Q EDC F+IL+G + Sbjct: 42 DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENY- 100 Query: 106 LSTLSLAADSKEDAVNWLSGLKILHQEAM--------NASTPTIIESWLRKQIYSVDQTR 157 +L L A+S + A W+SGL+ L + N +TP + WL K ++ Sbjct: 101 -ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFM--WL-KTVFEAADVD 156 Query: 158 RNSISLRELKT-ILPLINFKVSSAKFLKDKFVEIGAHKDELSF----EQFHLFYKKLMFE 212 N I L + ++ +N + AK ++ KF EI K++L+ E+F + +L Sbjct: 157 GNGIMLEDTSVELIKQLNPTLKEAK-IRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR 215 Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQ-EHWAQDLNKVRERMTK 271 + L V I N + DA+ D FL EQ H +D+ R + Sbjct: 216 PEVYFL-------LVQISKNKEYLDAN-----DLMLFLEAEQGVTHITEDICLDIIRRYE 263 Query: 272 FIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYL 331 ++ ++ FL +D F YL S E I+D + V QDM PLSHY+I++SHNTYL Sbjct: 264 LSEEGRQKG---FLAIDGFTQYLLSSECDIFDPEQKKV-AQDMTQPLSHYYINASHNTYL 319 Query: 332 TGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKD 391 DQ R + YIR L+MGCR +ELD DG D +P++ + TT + F V++ I Sbjct: 320 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINK 379 Query: 392 HAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKI 451 AFV S +P+IL + HCS+ QQ+ MA+ K+VFG+ L T+ S LPSP +L+ I Sbjct: 380 FAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMI 439 Query: 452 IIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSID 488 I+K KKL DV +E + + ++ E+ S+D Sbjct: 440 IVKGKKLPSDPDV---LEGEVTDEDEEAEMSRRMSVD 473 Score = 145 bits (367), Expect = 2e-34 Identities = 106/333 (31%), Positives = 164/333 (49%), Gaps = 31/333 (9%) Query: 864 PQGKNQKSFVFILEPKQQGDPPV--EFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921 P + K + + K DP V TD EE E++ ++ N + Sbjct: 430 PSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEA--------EMSRRMSVDYNGE---Q 478 Query: 922 KNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979 K + ELSDLV CK L ++ ++ E+ SF ET+A I + P D + YN+ Sbjct: 479 KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNK 538 Query: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039 K L+R+YP R+DSSN +P W CG Q+VA+NFQT M ++ F NG GYVL+ Sbjct: 539 KFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLR 598 Query: 1040 PESMRTEKYDPMPPESQRKIL-----MTLTVKVLGARHLPK-----LGRSIACPFVEVEI 1089 P MR E + + IL + L +K++ ++ PK + P+V +EI Sbjct: 599 PSIMRDEV--SYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656 Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 G D ++ +T V N +PI+ T E F++ P LA +RFVV ++D D F+ Sbjct: 657 HGIPADCSEQRTKTVQQNSDNPIFDETFE---FQVNLPELAMIRFVVLDDDYIGD-EFIG 712 Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 T P + ++ G+R VPL++ + +E +L V Sbjct: 713 QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 745 >gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] Length = 2302 Score = 187 bits (476), Expect = 4e-47 Identities = 100/214 (46%), Positives = 139/214 (64%), Gaps = 7/214 (3%) Query: 249 FLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDA 308 FL++ Q EH D ++ + KF + ++ + + + F +L +EN Sbjct: 1332 FLVNCQGEHCTYD--EILSIIQKF-EPSISMCHQGLMSFEGFARFLMDKENFASKNDESQ 1388 Query: 309 VDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKP 368 +++++ PLS+Y+I SSHNTYLTG QL+ ESS E Y + L GCR +ELDCWDG DG P Sbjct: 1389 ENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMP 1448 Query: 369 VIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDL 428 +IYHG T TTKI F +VV+AI AF+ S P+I+SIE HCS+ QQR MA+ FK VFG+ Sbjct: 1449 IIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEK 1508 Query: 429 LLTK---PTEASAD-QLPSPSQLREKIIIKHKKL 458 L+TK T+ S D LPSP QLR+K+++K+KKL Sbjct: 1509 LVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKL 1542 Score = 128 bits (322), Expect = 3e-29 Identities = 82/252 (32%), Positives = 131/252 (51%), Gaps = 17/252 (6%) Query: 939 PTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYD 998 PT+ + P I S E A + R+ L ++ L R YP R+DSSN + Sbjct: 1741 PTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPN 1800 Query: 999 PFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESM------RTEKYDPMP 1052 P WL G Q+VALN+QT D + +N A+F NG GYVL+P + +K+ P+ Sbjct: 1801 PLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLE 1860 Query: 1053 P--ESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLS 1110 +S + +LT+ V G P S+ P +EV++ G D+ F+T ++ N L+ Sbjct: 1861 RDLDSMDPAVYSLTI-VSGQNVCP--SNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLN 1917 Query: 1111 PIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNG 1170 P+W E+ F ++ +L FLRF V E + + A P+KA+K G+R + L+N Sbjct: 1918 PMW---NEQFLFHVHFEDLVFLRFAVVENNSSA---VTAQRIIPLKALKRGYRHLQLRNL 1971 Query: 1171 YSEDIELASLLV 1182 ++E +E++SL + Sbjct: 1972 HNEVLEISSLFI 1983 >gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] Length = 1194 Score = 173 bits (438), Expect = 1e-42 Identities = 146/429 (34%), Positives = 213/429 (49%), Gaps = 54/429 (12%) Query: 65 LDIMEIKEIRPG---KNSKDFERAKAVRQKEDCC----FTILYGTQFV-LSTLSLAADSK 116 L+ I IR G K+ K +AV + E+ + GT V +S + A++ Sbjct: 60 LECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENP 119 Query: 117 EDAVNWLSGLK-ILHQ-EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLIN 174 E W+ GL+ I+H A N S T ++ K + + + I +R + Sbjct: 120 EVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGK--IPVRSITRTFASGK 177 Query: 175 FKVSSAKFLKDKFVEIGAHKD----ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFIL 230 + + LK+ + G + + S+E+F+ +K+ + I D FKK Sbjct: 178 TEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKIC--PRTDIEDLFKKI------ 229 Query: 231 GNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMR----ETAEP--- 283 N D+ D V FL Q++ ++ E + F D E EP Sbjct: 230 -NGDKTDYLTV--DQLVSFLNEHQRDP------RLNEILFPFYDAKRAMQIIEMYEPDED 280 Query: 284 -----FLFVDEFLTYLFSRENSIWDEKYDAVDM-QDMNNPLSHYWISSSHNTYLTGDQLR 337 + D F YL S EN+ D +++ Q+M++PL+HY+ISSSHNTYLTG Q Sbjct: 281 LKKKGLISSDGFCRYLMSDENA--PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFG 338 Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGP--DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395 +SS E Y + L GCRC+ELDCWDG D +P+I HG T I F DV+QAIK+ AFV Sbjct: 339 GKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFV 398 Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA----SADQLPSPSQLREKI 451 TS +PVILS E HCS QQ M+K +++FGDLLL + E+ LPSP+ L+ KI Sbjct: 399 TSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKI 458 Query: 452 IIKHKKLGP 460 +IK+K+L P Sbjct: 459 LIKNKRLKP 467 Score = 125 bits (315), Expect = 2e-28 Identities = 86/279 (30%), Positives = 147/279 (52%), Gaps = 23/279 (8%) Query: 918 KYWEKNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLL 975 KY +I LS ++ Y +P ++ E + SF E+ ++ ++ + Sbjct: 553 KYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFV 612 Query: 976 KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTG 1035 YN++ ++R+YPKG RVDSSNY P W G QMV+LN+QT D MQ+N F NG G Sbjct: 613 NYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCG 672 Query: 1036 YVLQPESMR--TEKYDPMPPES-QRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEIC 1090 Y+L+P+ MR +DP I T +V+V+ + L K+G +VEV++ Sbjct: 673 YLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG-----TYVEVDMY 727 Query: 1091 GAEYD--NNKFKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNF 1147 G D +F+T +V +NGL+P++ +E F ++ P+LA LR VY++ + Sbjct: 728 GLPTDTIRKEFRTRMVMNNGLNPVY--NEESFVFRKVILPDLAVLRIAVYDD----NNKL 781 Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEM 1186 + P+ +++G+R + L+N ++ + L + +FC + Sbjct: 782 IGQRILPLDGLQAGYRHISLRNEGNKPLSLPT--IFCNI 818 >gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] Length = 1175 Score = 173 bits (438), Expect = 1e-42 Identities = 146/429 (34%), Positives = 213/429 (49%), Gaps = 54/429 (12%) Query: 65 LDIMEIKEIRPG---KNSKDFERAKAVRQKEDCC----FTILYGTQFV-LSTLSLAADSK 116 L+ I IR G K+ K +AV + E+ + GT V +S + A++ Sbjct: 60 LECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENP 119 Query: 117 EDAVNWLSGLK-ILHQ-EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLIN 174 E W+ GL+ I+H A N S T ++ K + + + I +R + Sbjct: 120 EVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGK--IPVRSITRTFASGK 177 Query: 175 FKVSSAKFLKDKFVEIGAHKD----ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFIL 230 + + LK+ + G + + S+E+F+ +K+ + I D FKK Sbjct: 178 TEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKIC--PRTDIEDLFKKI------ 229 Query: 231 GNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMR----ETAEP--- 283 N D+ D V FL Q++ ++ E + F D E EP Sbjct: 230 -NGDKTDYLTV--DQLVSFLNEHQRDP------RLNEILFPFYDAKRAMQIIEMYEPDED 280 Query: 284 -----FLFVDEFLTYLFSRENSIWDEKYDAVDM-QDMNNPLSHYWISSSHNTYLTGDQLR 337 + D F YL S EN+ D +++ Q+M++PL+HY+ISSSHNTYLTG Q Sbjct: 281 LKKKGLISSDGFCRYLMSDENA--PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFG 338 Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGP--DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395 +SS E Y + L GCRC+ELDCWDG D +P+I HG T I F DV+QAIK+ AFV Sbjct: 339 GKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFV 398 Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA----SADQLPSPSQLREKI 451 TS +PVILS E HCS QQ M+K +++FGDLLL + E+ LPSP+ L+ KI Sbjct: 399 TSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKI 458 Query: 452 IIKHKKLGP 460 +IK+K+L P Sbjct: 459 LIKNKRLKP 467 Score = 125 bits (315), Expect = 2e-28 Identities = 86/279 (30%), Positives = 147/279 (52%), Gaps = 23/279 (8%) Query: 918 KYWEKNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLL 975 KY +I LS ++ Y +P ++ E + SF E+ ++ ++ + Sbjct: 553 KYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFV 612 Query: 976 KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTG 1035 YN++ ++R+YPKG RVDSSNY P W G QMV+LN+QT D MQ+N F NG G Sbjct: 613 NYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCG 672 Query: 1036 YVLQPESMR--TEKYDPMPPES-QRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEIC 1090 Y+L+P+ MR +DP I T +V+V+ + L K+G +VEV++ Sbjct: 673 YLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG-----TYVEVDMY 727 Query: 1091 GAEYD--NNKFKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNF 1147 G D +F+T +V +NGL+P++ +E F ++ P+LA LR VY++ + Sbjct: 728 GLPTDTIRKEFRTRMVMNNGLNPVY--NEESFVFRKVILPDLAVLRIAVYDD----NNKL 781 Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEM 1186 + P+ +++G+R + L+N ++ + L + +FC + Sbjct: 782 IGQRILPLDGLQAGYRHISLRNEGNKPLSLPT--IFCNI 818 >gi|25188201 phospholipase C, zeta 1 [Homo sapiens] Length = 608 Score = 172 bits (435), Expect = 2e-42 Identities = 112/341 (32%), Positives = 183/341 (53%), Gaps = 33/341 (9%) Query: 154 DQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKD-ELSFEQFHLFYKKLMFE 212 D R I+L + + +L ++ + S +K F + K ++ E+F Y+ + Sbjct: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIH-VKQIFKDNDRLKQGRITIEEFRAIYR--IIT 68 Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVR--ERMT 270 ++ I++ F NT + + + +FL EQ +A +++K E + Sbjct: 69 HREEIIEIF----------NTYSENRKILLASNLAQFLTQEQ---YAAEMSKAIAFEIIQ 115 Query: 271 KFIDDTMRETAEPF-LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNT 329 K+ + + E + + ++ F Y+ SRE ++ + V QDM +PL+ Y+ISSSHNT Sbjct: 116 KY--EPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKV-YQDMTHPLNDYFISSSHNT 172 Query: 330 YLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAI 389 YL DQL S Y+ L GCRC+E+DCWDG +PV+YHG+T T+K+ F V+QAI Sbjct: 173 YLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAI 232 Query: 390 KDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLRE 449 +AF+TS +PV+LS+E HCS QQ MA + FG+ LL+ + D LPSP L+ Sbjct: 233 HKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKF 292 Query: 450 KIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQK 490 KI++K+KK+G K+ H+++G D+ D++ Sbjct: 293 KILVKNKKIG----------TLKETHERKGSDKRGDNQDKE 323 Score = 148 bits (374), Expect = 3e-35 Identities = 93/263 (35%), Positives = 137/263 (52%), Gaps = 9/263 (3%) Query: 926 IAIELSDLVVYCKPTSKTKDNLEN---PDFREIRSFVETKADSIIRQKPVDLLKYNQKGL 982 IA+ LSDLV+Y K K K + F E S ET+A + + + + + + +K + Sbjct: 345 IALALSDLVIYTK-AEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFI 403 Query: 983 TRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPES 1042 TR+YPK R DSSN++P W G QMVALNFQT M + + F NG +GY+L+P Sbjct: 404 TRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF 463 Query: 1043 MRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI--ACPFVEVEICGAEYDNNKFK 1100 +R K P + + +TLT++++ LP S V +E+ G D K + Sbjct: 464 LRESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQ 523 Query: 1101 TTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160 T V+ N SP W E TF I+ P LA +RFVV + + + FL T P+ + Sbjct: 524 TRVIKKNAFSPRW---NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNK 580 Query: 1161 GFRSVPLKNGYSEDIELASLLVF 1183 G+R +PL + E +E ASL V+ Sbjct: 581 GYRRIPLFSRMGESLEPASLFVY 603 >gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform a [Homo sapiens] Length = 1216 Score = 157 bits (398), Expect = 5e-38 Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%) Query: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345 VD F+ YL EN + EK D +DM+ PLSHY+I+SSHNTYLT QL SS E Y Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349 Query: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403 + L GCRC+ELDCW G + +PVI HG+T TT+I F +V++AI + AF TS FP++L Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409 Query: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457 S E H S +QQ MA+ + +FGD LL +P E S LPSP L KI++K+KK Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468 Score = 156 bits (394), Expect = 1e-37 Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%) Query: 929 ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985 E+S+LV Y +P + N F E+ SFVETK + + PV+ ++YN+ L+R+ Sbjct: 539 EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597 Query: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044 YPKG RVDSSNY P W G QMVALNFQT D MQ+N ++ NG++GY L+PE MR Sbjct: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657 Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098 + +DP I+ TL+VK++ + L K+G +VEV++ G D + Sbjct: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712 Query: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157 FKT N ++P+W +E + F ++ P LA LR VYEE F+ H P++A Sbjct: 713 FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766 Query: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187 ++ G+ + L+N ++ + L ++ V+ E++ Sbjct: 767 IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796 >gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform b [Homo sapiens] Length = 1173 Score = 157 bits (398), Expect = 5e-38 Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%) Query: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345 VD F+ YL EN + EK D +DM+ PLSHY+I+SSHNTYLT QL SS E Y Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349 Query: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403 + L GCRC+ELDCW G + +PVI HG+T TT+I F +V++AI + AF TS FP++L Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409 Query: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457 S E H S +QQ MA+ + +FGD LL +P E S LPSP L KI++K+KK Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468 Score = 156 bits (394), Expect = 1e-37 Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%) Query: 929 ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985 E+S+LV Y +P + N F E+ SFVETK + + PV+ ++YN+ L+R+ Sbjct: 539 EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597 Query: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044 YPKG RVDSSNY P W G QMVALNFQT D MQ+N ++ NG++GY L+PE MR Sbjct: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657 Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098 + +DP I+ TL+VK++ + L K+G +VEV++ G D + Sbjct: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712 Query: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157 FKT N ++P+W +E + F ++ P LA LR VYEE F+ H P++A Sbjct: 713 FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766 Query: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187 ++ G+ + L+N ++ + L ++ V+ E++ Sbjct: 767 IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796 >gi|11386139 phospholipase C beta 3 [Homo sapiens] Length = 1234 Score = 153 bits (387), Expect = 9e-37 Identities = 101/278 (36%), Positives = 152/278 (54%), Gaps = 18/278 (6%) Query: 929 ELSDLVVYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985 E+S LV Y +P S N F E+ SFVETKA + + P++ ++YN++ L+R+ Sbjct: 589 EMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRI 647 Query: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044 YPKG RVDSSNY P W G Q+VALNFQT D MQ+N +F NGR+GY+L+PE MR Sbjct: 648 YPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRR 707 Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKT 1101 + +DP I+ L VKV+ + L I +VEV++ G D K++T Sbjct: 708 PDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRT 764 Query: 1102 TVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160 N +P+W +E F ++ P LA LR +EE F+ H P+ A++S Sbjct: 765 RTSQGNSFNPVW--DEEPFDFPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRS 818 Query: 1161 GFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYS 1198 G+ V L+N ++ + L +LL++ E + + + Y+ Sbjct: 819 GYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYA 856 Score = 148 bits (373), Expect = 4e-35 Identities = 138/430 (32%), Positives = 202/430 (46%), Gaps = 61/430 (14%) Query: 65 LDIMEIKEIRPGKNSKDFERAKAVRQK----------EDCCFTILYGTQFVLST-LSLAA 113 LDI I++ R G+ ++ + +R+ E+ T++ G V + L+ A Sbjct: 64 LDISSIRDTRTGRYAR-LPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMA 122 Query: 114 DSKEDAVNWLSGLKILHQE--AMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILP 171 + A W L L A NAS T + K V+Q R I ++ + + Sbjct: 123 VQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGR--IPVKNILKMFS 180 Query: 172 LINFKVSSA------KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225 +V +A KF + + + DE S E F F KL D Sbjct: 181 ADKKRVETALESCGLKFNRSESIR----PDEFSLEIFERFLNKLCLRPDI--------DK 228 Query: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKV-----RERMTKFIDDTMRET 280 + +G +P + L DF I+++Q LN+V R + + + E Sbjct: 229 ILLEIGAKGKPYLTLEQLMDF----INQKQRD--PRLNEVLYPPLRPSQARLLIEKY-EP 281 Query: 281 AEPFLFVDE-----FLTYLFSRENSIWDEKYDAVDMQ-DMNNPLSHYWISSSHNTYLTGD 334 + FL D+ F YL EN I +A+D+ DM PLS Y+I+SSHNTYLT Sbjct: 282 NQQFLERDQMSMEGFSRYLGGEENGILP--LEALDLSTDMTQPLSAYFINSSHNTYLTAG 339 Query: 335 QLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDH 392 QL SS E Y + L GCRC+ELD W G P+ +P I HG+T TT++ DV++AI + Sbjct: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399 Query: 393 AFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQL 447 AF TS +PVILS E H S +QQ MA+ + +FGD LL +P + A LPSP L Sbjct: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459 Query: 448 REKIIIKHKK 457 +I++K+KK Sbjct: 460 MGRILVKNKK 469 >gi|95147333 phospholipase C, beta 2 [Homo sapiens] Length = 1185 Score = 150 bits (380), Expect = 6e-36 Identities = 79/152 (51%), Positives = 100/152 (65%), Gaps = 7/152 (4%) Query: 313 DMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVI 370 DM PL+HY+I+SSHNTYLT Q SS E Y + L GCRC+ELDCW G PD +P+I Sbjct: 313 DMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPII 372 Query: 371 YHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLL 429 HG+T TT I F + ++AI + AF TS +P+ILS E H S QQ MA+ + +FGD+L Sbjct: 373 THGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDML 432 Query: 430 LTKPTE----ASADQLPSPSQLREKIIIKHKK 457 LT+P E LPSP LR KI+IK+KK Sbjct: 433 LTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK 464 Score = 141 bits (355), Expect = 5e-33 Identities = 96/267 (35%), Positives = 146/267 (54%), Gaps = 17/267 (6%) Query: 929 ELSDLVVYCKPTSKTKDNLENPDFRE--IRSFVETKADSIIRQKPVDLLKYNQKGLTRVY 986 E+S LV Y +PT R I SF E KA ++ + V + YN++ ++R+Y Sbjct: 545 EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIY 604 Query: 987 PKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR-- 1044 PKG R+DSSNY P W G QMVALNFQT D MQ N A+F NG++GY+L+ E MR Sbjct: 605 PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRP 664 Query: 1045 TEKYDPMPPES-QRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKTT 1102 ++++P + + TL++ V+ + L + RS+ +VEVE+ G D +++T Sbjct: 665 DKQFNPFSVDRIDVVVATTLSITVISGQFLSE--RSVR-TYVEVELFGLPGDPKRRYRTK 721 Query: 1103 V-VNDNGLSPIWAPTQEKVTFE-IYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160 + + N ++P+W +E FE I P LA LR V EE FL H PI A+ S Sbjct: 722 LSPSTNSINPVW--KEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNS 775 Query: 1161 GFRSVPLKNGYSEDIELASLLVFCEMR 1187 G+ + L + + + + +L +F EM+ Sbjct: 776 GYHHLCLHSESNMPLTMPALFIFLEMK 802 >gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens] Length = 593 Score = 85.5 bits (210), Expect = 3e-16 Identities = 68/240 (28%), Positives = 114/240 (47%), Gaps = 29/240 (12%) Query: 531 KWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRS 590 +WFH + AE LL T G DG+FL R S++ P D+TLS R+G V H +I++ Sbjct: 5 RWFHPNITG-VEAENLLL-----TRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQN 58 Query: 591 TMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFE---LRLTDPVPNPNPHESKPWY 647 T + Y L F+++ L+Q+Y E H + E + L P+ +P S+ W+ Sbjct: 59 TGD----YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADP-TSERWF 113 Query: 648 YDSLSRGEAEDMLMRIPRDGAFLIRKREG-----------SDSYAITFRARGKVKHCRIN 696 + LS EAE +L + G+FL+R+ + D + + KV H I Sbjct: 114 HGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIR 173 Query: 697 RDGRHFVLGTSAYFESLVELVSYYEKH----SLYRKMRLRYPVTPELLERYNMERDINSL 752 + +G F+SL +LV +Y+K+ +L ++L+ P+ + +E + L Sbjct: 174 CQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVREL 233 Score = 52.4 bits (124), Expect = 3e-06 Identities = 30/100 (30%), Positives = 52/100 (52%), Gaps = 7/100 (7%) Query: 643 SKPWYYDSLSRGEAEDMLMRIPRDGAFLIR-KREGSDSYAITFRARGKVKHCRINRDGRH 701 S+ W++ +++ EAE++L+ DG+FL R + + ++ R G V H +I G + Sbjct: 3 SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDY 62 Query: 702 FVLGTSAYFESLVELVSYYEKHSLYRK------MRLRYPV 735 + L F +L ELV YY +H K + L+YP+ Sbjct: 63 YDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102 >gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 287 Score = 82.0 bits (201), Expect = 3e-15 Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%) Query: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692 VP P + +PWY ++ R +AE +++ R+ + +L+R R + S YAI+ + + KH Sbjct: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158 Query: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745 +I RDG F + + F+SL+ELV YY+ HSL R L++P PE Sbjct: 159 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 217 Query: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804 R NSL + P + ++ A YD+ A+ ELS +G ++ +K Sbjct: 218 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 264 Query: 805 GWWKGDYGTRIQQYFPSNYVED 826 GWW+G+ R+ +FPS YVE+ Sbjct: 265 GWWRGEVNGRV-GWFPSTYVEE 285 >gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 847 Score = 82.0 bits (201), Expect = 3e-15 Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%) Query: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692 VP P + +PWY ++ R +AE +++ R+ + +L+R R + S YAI+ + + KH Sbjct: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718 Query: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745 +I RDG F + + F+SL+ELV YY+ HSL R L++P PE Sbjct: 719 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 777 Query: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804 R NSL + P + ++ A YD+ A+ ELS +G ++ +K Sbjct: 778 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 824 Query: 805 GWWKGDYGTRIQQYFPSNYVED 826 GWW+G+ R+ +FPS YVE+ Sbjct: 825 GWWRGEVNGRV-GWFPSTYVEE 845 >gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo sapiens] Length = 217 Score = 77.4 bits (189), Expect = 8e-14 Identities = 56/190 (29%), Positives = 85/190 (44%), Gaps = 33/190 (17%) Query: 640 PHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRINRD 698 PH PW++ + R +AE+ML + DGAFLIR+ E + ++++ + V+H ++ RD Sbjct: 57 PH---PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRD 113 Query: 699 GRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRM 758 G F SL ELV Y+ S+ R ++ RDI + Sbjct: 114 GAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQI-------------FLRDIEQV------ 154 Query: 759 YVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQY 818 P P V+AL+D+ + EL F RG IH + WWKG + Sbjct: 155 --------PQQP-TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGM- 204 Query: 819 FPSNYVEDIS 828 FP NYV ++ Sbjct: 205 FPRNYVTPVN 214 Score = 55.8 bits (133), Expect = 2e-07 Identities = 52/174 (29%), Positives = 82/174 (47%), Gaps = 25/174 (14%) Query: 497 AIADAKLSFS-DDIEQTMEEEVPQDIPPTELHFGE-------------KWFHKKVEKRTS 542 A AD +LSF DI + + EE Q+ EL+ + WF K+ R Sbjct: 11 ATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIP-RAK 69 Query: 543 AEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLT 602 AE++L + DG FL+RESE+ P D++LS VQH ++ + G KY+L Sbjct: 70 AEEMLSKQ-----RHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDGAGKYFLW 121 Query: 603 DNLTFSSIYALIQHYRETHL-RCAEFELRLTDPVPNPNPHESKPWYYDSLSRGE 655 + F+S+ L+ ++R T + R + LR + VP + + +D GE Sbjct: 122 -VVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGE 174 Score = 37.4 bits (85), Expect = 0.092 Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 2/51 (3%) Query: 776 ALYDYKAKRSDELSFCRGALIHNVSKE-PGGWWKGDYGTRIQQYFPSNYVE 825 A YD+KA DELSF RG ++ +++E W+K + + + P NY+E Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGK-DGFIPKNYIE 54 >gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 839 Score = 75.5 bits (184), Expect = 3e-13 Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 28/205 (13%) Query: 634 PVPNPNPHE----SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREG-SDSYAITFRARG 688 P+ P E + PW+ ++ R + D L++ G +LIR+R ++ +AI+ + Sbjct: 647 PISRPPSREIDYTAYPWFAGNMERQQT-DNLLKSHASGTYLIRERPAEAERFAISIKFND 705 Query: 689 KVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVTPELLERY 743 +VKH ++ + + F+SL+ELV YY+ HSL + L+YP Sbjct: 706 EVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYK------- 758 Query: 744 NMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEP 803 + ER + S ++ P I T A Y++ A+ ELS G ++ S+ Sbjct: 759 SRERSASRASSRSPVFT-PRVIG------TAVARYNFAARDMRELSLREGDVVRIYSRIG 811 Query: 804 G--GWWKGDYGTRIQQYFPSNYVED 826 G GWWKG+ RI +FPS YVE+ Sbjct: 812 GDQGWWKGETNGRI-GWFPSTYVEE 835 >gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 878 Score = 74.3 bits (181), Expect = 7e-13 Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 29/220 (13%) Query: 634 PVPNPNPHE----SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREG-SDSYAITFRARG 688 P+ P E + PW+ ++ R + D L++ G +LIR+R ++ +AI+ + Sbjct: 657 PISRPPSREIDYTAYPWFAGNMERQQT-DNLLKSHASGTYLIRERPAEAERFAISIKFND 715 Query: 689 KVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPV-TPELLER 742 +VKH ++ + + F+SL+ELV YY+ HSL + L+YP + E Sbjct: 716 EVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSAS 775 Query: 743 YNMERDINSLYDVSRMYVDPSEIN-----PSMP---------QRTVKALYDYKAKRSDEL 788 R S + ++ P ++ PS P T A Y++ A+ EL Sbjct: 776 RASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMREL 835 Query: 789 SFCRGALIHNVSKEPG--GWWKGDYGTRIQQYFPSNYVED 826 S G ++ S+ G GWWKG+ RI +FPS YVE+ Sbjct: 836 SLREGDVVRIYSRIGGDQGWWKGETNGRI-GWFPSTYVEE 874 >gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] Length = 1047 Score = 70.1 bits (170), Expect = 1e-11 Identities = 80/337 (23%), Positives = 138/337 (40%), Gaps = 90/337 (26%) Query: 514 EEEV--PQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPN 571 EEEV P PPT +W+H K+++ + E+L Q GK G++L+RES+ P Sbjct: 166 EEEVAIPLTAPPTN-----QWYHGKLDRTIAEERLRQ------AGKSGSYLIRESDRRPG 214 Query: 572 DYTLSFW-RSGRVQHCRIRST---------------------------MEGGTLKYYL-- 601 + LSF + V H RI + ++G L Y + Sbjct: 215 SFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAP 274 Query: 602 ---------------------TDNLTFSSIYALIQHYR-------ETHLRCAEFELRLTD 633 TD ++F I H T+LR E L + D Sbjct: 275 PEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVED 334 Query: 634 PVPN----PNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARG 688 V +PHE K W++ +S+ EA ++LM + + +FL+R + + Y++ FR Sbjct: 335 LVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNE 394 Query: 689 KVKHCRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMER 747 ++ +I F++G Y+ S+ +++ +Y K + L+ PV + + E+ Sbjct: 395 NIQRFKICPTPNNQFMMG-GRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQ-----DQEQ 448 Query: 748 DINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKR 784 +N VD EI ++ ++T A Y K+ Sbjct: 449 VLNDT-------VDGKEIYNTIRRKTKDAFYKNIVKK 478 Score = 52.8 bits (125), Expect = 2e-06 Identities = 53/241 (21%), Positives = 102/241 (42%), Gaps = 36/241 (14%) Query: 442 PSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADA 501 P + R + I+ + K+ ++ D H + + +MW + + Sbjct: 277 PVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMW-------------VTNL 323 Query: 502 KLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTF 561 + I + + EEV ++ P H G+ WFH K+ K+ + L+ T G+ +F Sbjct: 324 RTDEQGLIVEDLVEEVGREEDP---HEGKIWFHGKISKQEAYNLLM------TVGQVCSF 374 Query: 562 LVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETH 621 LVR S+ P DY+L F + +Q +I T ++ ++SI +I HYR+ Sbjct: 375 LVRPSDNTPGDYSLYFRTNENIQRFKICPTPN----NQFMMGGRYYNSIGDIIDHYRKEQ 430 Query: 622 LRCAEFELRLTDPVPNPNPHE------SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKRE 675 + + L +PVP + + Y+++ R + I + G +L++K + Sbjct: 431 IVEGYY---LKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKG-YLLKKGK 486 Query: 676 G 676 G Sbjct: 487 G 487 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 48,169,104 Number of Sequences: 37866 Number of extensions: 2203431 Number of successful extensions: 6576 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 189 Number of HSP's successfully gapped in prelim test: 131 Number of HSP's that attempted gapping in prelim test: 5728 Number of HSP's gapped (non-prelim): 692 length of query: 1265 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1151 effective length of database: 13,930,794 effective search space: 16034343894 effective search space used: 16034343894 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.