Guide to the Human Genome
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Search of human proteins with 117320537

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
         (1265 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                 2576   0.0  
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]        1233   0.0  
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]        1231   0.0  
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]         241   4e-63
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]        241   4e-63
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]           235   2e-61
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]           235   2e-61
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]            235   2e-61
gi|78499633 phospholipase C, eta 2 [Homo sapiens]                     231   3e-60
gi|19115964 phospholipase C delta 3 [Homo sapiens]                    230   7e-60
gi|14249340 phospholipase C, delta 4 [Homo sapiens]                   219   2e-56
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]          213   1e-54
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]          213   1e-54
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]          199   1e-50
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]          199   1e-50
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]                187   4e-47
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]           173   1e-42
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]           173   1e-42
gi|25188201 phospholipase C, zeta 1 [Homo sapiens]                    172   2e-42
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso...   157   5e-38
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso...   157   5e-38
gi|11386139 phospholipase C beta 3 [Homo sapiens]                     153   9e-37
gi|95147333 phospholipase C, beta 2 [Homo sapiens]                    150   6e-36
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...    86   3e-16
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...    82   3e-15
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    82   3e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    77   8e-14
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    75   3e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    74   7e-13
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        70   1e-11

>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score = 2576 bits (6678), Expect = 0.0
 Identities = 1265/1265 (100%), Positives = 1265/1265 (100%)

Query: 1    MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK 60
            MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
Sbjct: 1    MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK 60

Query: 61   IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV 120
            IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
Sbjct: 61   IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV 120

Query: 121  NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA 180
            NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
Sbjct: 121  NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA 180

Query: 181  KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA 240
            KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
Sbjct: 181  KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA 240

Query: 241  VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS 300
            VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
Sbjct: 241  VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS 300

Query: 301  IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC 360
            IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
Sbjct: 301  IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC 360

Query: 361  WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA 420
            WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
Sbjct: 361  WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA 420

Query: 421  FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE 480
            FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
Sbjct: 421  FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE 480

Query: 481  LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR 540
            LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
Sbjct: 481  LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR 540

Query: 541  TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY 600
            TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
Sbjct: 541  TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY 600

Query: 601  LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML 660
            LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
Sbjct: 601  LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML 660

Query: 661  MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY 720
            MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
Sbjct: 661  MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY 720

Query: 721  EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY 780
            EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
Sbjct: 721  EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY 780

Query: 781  KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII 840
            KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
Sbjct: 781  KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII 840

Query: 841  EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF 900
            EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF
Sbjct: 841  EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF 900

Query: 901  QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE 960
            QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
Sbjct: 901  QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE 960

Query: 961  TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY 1020
            TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
Sbjct: 961  TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY 1020

Query: 1021 MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI 1080
            MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
Sbjct: 1021 MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI 1080

Query: 1081 ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED 1140
            ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
Sbjct: 1081 ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED 1140

Query: 1141 MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC 1200
            MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
Sbjct: 1141 MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC 1200

Query: 1201 RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN 1260
            RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
Sbjct: 1201 RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN 1260

Query: 1261 SKFYS 1265
            SKFYS
Sbjct: 1261 SKFYS 1265


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score = 1233 bits (3190), Expect = 0.0
 Identities = 645/1278 (50%), Positives = 866/1278 (67%), Gaps = 39/1278 (3%)

Query: 11   AEYEKSQIKRALELGTVMTVFSFRKST-PERRTVQVIMETRQVAWSKTADKIEGFLDIME 69
            ++ E   + R+LE+GTVMT+F  +KS  PER+T QV +ETRQ+ WS+ ADKIEG +DI E
Sbjct: 18   SDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIRE 77

Query: 70   IKEIRPGKNSKDFERAK---AVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
            IKEIRPGK S+DF+R +   A R  +  CF ILYG +F L TLSL A S+++   W+ GL
Sbjct: 78   IKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGL 137

Query: 127  KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186
              L ++ + A TP  IE WLRKQ YSVD+ R + IS ++LK +L  +N++V + +FL+++
Sbjct: 138  TWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRER 197

Query: 187  FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246
              ++     ++++ QF   Y+ LM+  QK++   F + S+   L   +RP+   V L +F
Sbjct: 198  LTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEAST---LRAGERPELCRVSLPEF 254

Query: 247  QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306
            Q+FL+  Q E WA D  +V+E M  F+ D +RE  EP+ F+DEF+T+LFS+ENS+W+ + 
Sbjct: 255  QQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQL 314

Query: 307  DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366
            DAV    MNNPLSHYWISSSHNTYLTGDQ  SESS EAY RCLRMGCRCIELDCWDGPDG
Sbjct: 315  DAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG 374

Query: 367  KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
             PVIYHG T TTKIKF DV+  IK+HAFV S +PVILSIE+HCS+ QQR+MA+ FK+V G
Sbjct: 375  MPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLG 434

Query: 427  DLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRG---DVDVNM---EDKKDEHKQQGE 480
            D LLTKP E SAD LPSP+QL+ KI+IKHKKL       +V  +M   E+      + G 
Sbjct: 435  DTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGI 494

Query: 481  LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTM---EEEVPQDI-PPTELHFGEKWFHKK 536
            LY+ D ++ +W  HY  +  +K+ +S++        +EE P+++   TELH  EKWFH K
Sbjct: 495  LYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGK 554

Query: 537  V----EKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592
            +    + R  AE+LL EYC+ETG  DG+FLVRESETF  DYTLSFWR+G+VQHCRI S  
Sbjct: 555  LGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQ 614

Query: 593  EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLS 652
            + GT K++LTDNL F S+Y LI HY++  LRC EFE+RL++PVP  N HESK WY+ SL+
Sbjct: 615  DAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLT 674

Query: 653  RGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES 712
            R +AE MLMR+PRDGAFL+RKR   +SYAI+FRA GK+KHCR+ ++G+  +LG S  F+S
Sbjct: 675  RAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSE-FDS 733

Query: 713  LVELVSYYEKHSLYRKMRLRYPVTPELLERY-NMERDINSLYDVSR--MYVDPSEINPSM 769
            LV+L+SYYEKH LYRKM+LRYP+  E LE+    E D  +LY+      YV   E NP M
Sbjct: 734  LVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYV---EANP-M 789

Query: 770  P--QRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDI 827
            P  +  VKAL+DYKA+R DEL+F + A+I NV K+ GGWW+GDYG + Q +FPSNYVE++
Sbjct: 790  PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEM 849

Query: 828  STADFEELEKQIIEDN-PLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPV 886
                  E E++ +++N PLG L RG+LD+    +   P+GKN + FVF +         +
Sbjct: 850  VNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSL 909

Query: 887  EFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPT--SKTK 944
            + A D  EEL +W + IRE+    D +    K  E+ + IA+ELS+LVVYC+P    + K
Sbjct: 910  DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969

Query: 945  DNLENPDFREIRSFVETKADSII-RQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLW 1003
               E   +R++ SF ETKA+  + + K    L+YN+  L+R+YPKGQR+DSSNYDP  +W
Sbjct: 970  IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029

Query: 1004 LCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKI-LMT 1062
            +CGSQ+VALNFQT DK MQMN ALF      GYVLQP +MR E +DP    S R +    
Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCA 1089

Query: 1063 LTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTF 1122
            ++++VLGARHLPK GR I CPFVE+E+ GAEYD+ K KT  V DNGL+P+W    +   F
Sbjct: 1090 ISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW--PAKPFHF 1147

Query: 1123 EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
            +I +P  AFLRFVVYEEDMFSD NFLA AT+P+K +K+G+R+VPLKN YSED+ELASLL+
Sbjct: 1148 QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207

Query: 1183 FCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQL 1242
              ++ P  E+ +    S   LR R  + + QLF     +    +      ++F +++  L
Sbjct: 1208 KIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHL 1267

Query: 1243 QLYQEKCNKRL-REKRVS 1259
              + +   +R  R  RV+
Sbjct: 1268 ADHFDSRERRAPRRTRVN 1285


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 1231 bits (3185), Expect = 0.0
 Identities = 645/1279 (50%), Positives = 866/1279 (67%), Gaps = 40/1279 (3%)

Query: 11   AEYEKSQIKRALELGTVMTVFSFRKST-PERRTVQVIMETRQVAWSKTADKIEGFLDIME 69
            ++ E   + R+LE+GTVMT+F  +KS  PER+T QV +ETRQ+ WS+ ADKIEG +DI E
Sbjct: 18   SDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIRE 77

Query: 70   IKEIRPGKNSKDFERAK---AVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
            IKEIRPGK S+DF+R +   A R  +  CF ILYG +F L TLSL A S+++   W+ GL
Sbjct: 78   IKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGL 137

Query: 127  KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186
              L ++ + A TP  IE WLRKQ YSVD+ R + IS ++LK +L  +N++V + +FL+++
Sbjct: 138  TWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRER 197

Query: 187  FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246
              ++     ++++ QF   Y+ LM+  QK++   F + S+   L   +RP+   V L +F
Sbjct: 198  LTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEAST---LRAGERPELCRVSLPEF 254

Query: 247  QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306
            Q+FL+  Q E WA D  +V+E M  F+ D +RE  EP+ F+DEF+T+LFS+ENS+W+ + 
Sbjct: 255  QQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQL 314

Query: 307  DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366
            DAV    MNNPLSHYWISSSHNTYLTGDQ  SESS EAY RCLRMGCRCIELDCWDGPDG
Sbjct: 315  DAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG 374

Query: 367  KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
             PVIYHG T TTKIKF DV+  IK+HAFV S +PVILSIE+HCS+ QQR+MA+ FK+V G
Sbjct: 375  MPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLG 434

Query: 427  DLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRG---DVDVNM---EDKKDEHKQQGE 480
            D LLTKP E SAD LPSP+QL+ KI+IKHKKL       +V  +M   E+      + G 
Sbjct: 435  DTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGI 494

Query: 481  LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTM---EEEVPQDI-PPTELHFGEKWFHKK 536
            LY+ D ++ +W  HY  +  +K+ +S++        +EE P+++   TELH  EKWFH K
Sbjct: 495  LYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGK 554

Query: 537  V----EKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592
            +    + R  AE+LL EYC+ETG  DG+FLVRESETF  DYTLSFWR+G+VQHCRI S  
Sbjct: 555  LGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQ 614

Query: 593  EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLS 652
            + GT K++LTDNL F S+Y LI HY++  LRC EFE+RL++PVP  N HESK WY+ SL+
Sbjct: 615  DAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLT 674

Query: 653  RGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES 712
            R +AE MLMR+PRDGAFL+RKR   +SYAI+FRA GK+KHCR+ ++G+  +LG S  F+S
Sbjct: 675  RAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSE-FDS 733

Query: 713  LVELVSYYEKHSLYRKMRLRYPVTPELLERY-NMERDINSLYDVSR--MYVDPSEINPSM 769
            LV+L+SYYEKH LYRKM+LRYP+  E LE+    E D  +LY+      YV   E NP M
Sbjct: 734  LVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYV---EANP-M 789

Query: 770  P--QRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDI 827
            P  +  VKAL+DYKA+R DEL+F + A+I NV K+ GGWW+GDYG + Q +FPSNYVE++
Sbjct: 790  PTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEM 849

Query: 828  STADFEELEKQIIEDN-PLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPV 886
                  E E++ +++N PLG L RG+LD+    +   P+GKN + FVF +         +
Sbjct: 850  VNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSL 909

Query: 887  EFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPT--SKTK 944
            + A D  EEL +W + IRE+    D +    K  E+ + IA+ELS+LVVYC+P    + K
Sbjct: 910  DVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEK 969

Query: 945  DNLENPDFREIRSFVETKADSII-RQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLW 1003
               E   +R++ SF ETKA+  + + K    L+YN+  L+R+YPKGQR+DSSNYDP  +W
Sbjct: 970  IGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMW 1029

Query: 1004 LCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKI-LMT 1062
            +CGSQ+VALNFQT DK MQMN ALF      GYVLQP +MR E +DP    S R +    
Sbjct: 1030 ICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCA 1089

Query: 1063 LTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTF 1122
            ++++VLGARHLPK GR I CPFVE+E+ GAEYD+ K KT  V DNGL+P+W    +   F
Sbjct: 1090 ISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW--PAKPFHF 1147

Query: 1123 EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
            +I +P  AFLRFVVYEEDMFSD NFLA AT+P+K +K+G+R+VPLKN YSED+ELASLL+
Sbjct: 1148 QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLI 1207

Query: 1183 FCEMRPVLESEEELYS-SCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQ 1241
              ++ P  +   +L   S   LR R  + + QLF     +    +      ++F +++  
Sbjct: 1208 KIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEH 1267

Query: 1242 LQLYQEKCNKRL-REKRVS 1259
            L  + +   +R  R  RV+
Sbjct: 1268 LADHFDSRERRAPRRTRVN 1286


>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
          Length = 756

 Score =  241 bits (614), Expect = 4e-63
 Identities = 150/395 (37%), Positives = 221/395 (55%), Gaps = 22/395 (5%)

Query: 67  IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
           I +I+E+R G  ++  E+  A    ED CF+I++  Q   +TL L A S  DA +W+ GL
Sbjct: 69  IEDIQEVRMGHRTEGLEKF-ARDVPEDRCFSIVFKDQ--RNTLDLIAPSPADAQHWVLGL 125

Query: 127 -KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKD 185
            KI+H    +      ++ W+   +   D+ + N +S +EL+  L  +N +V  + + + 
Sbjct: 126 HKIIHHSG-SMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YARK 183

Query: 186 KFVEIG-AHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLH 244
            F E   +  D L  E+   FYK  M  Q+  I   F + +               + + 
Sbjct: 184 IFRECDHSQTDSLEDEEIEAFYK--MLTQRVEIDRTFAEAAG----------SGETLSVD 231

Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304
               FL H+Q+E  A     +   + +  + +    A+  +  D FL YL S + S +  
Sbjct: 232 QLVTFLQHQQREEAAGPALALS--LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSL 289

Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364
            +  V  QDM  PLSHY +SSSHNTYL  DQL   SS EAYIR L  GCRC+ELDCWDGP
Sbjct: 290 AHRRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGP 348

Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424
           + +P+IYHG+T T+KI F DV++AI+D+AF  S +PVILS+E HC++EQQR MA+    +
Sbjct: 349 NQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAI 408

Query: 425 FGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLG 459
            G +LL +P +   + LPSP QL+ KI++K KKLG
Sbjct: 409 LGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLG 443



 Score =  147 bits (372), Expect = 5e-35
 Identities = 101/321 (31%), Positives = 159/321 (49%), Gaps = 28/321 (8%)

Query: 875  ILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLV 934
            +L P  +G P     +D  E      +++R    +   KE+ ++       +A ELSD+V
Sbjct: 445  LLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRV-QHKPKEDKLR-------LAQELSDMV 496

Query: 935  VYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQR 991
            +YCK       +        F E+ SF E +A  ++++     +++N   L+R+YP G R
Sbjct: 497  IYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWR 556

Query: 992  VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPM 1051
             DSSNY P  +W  G Q+VALNFQT    M +    F  NG  GYVL+P  +R    DP 
Sbjct: 557  TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR----DPN 612

Query: 1052 PPESQRKILM-------TLTVKVLGARHLPKLGR---SIACPFVEVEICGAEYDNNKFKT 1101
               + R +          L ++V+  + LPK+ +   SI  P V VEI G   D    +T
Sbjct: 613  GTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQT 672

Query: 1102 TVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSG 1161
             V+ +NG +P W     +  FE+  P+LA +RF+V + D  S  +F+  +T P+ ++K G
Sbjct: 673  AVITNNGFNPWW---DTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 729

Query: 1162 FRSVPLKNGYSEDIELASLLV 1182
            +R V L +   +    A+L V
Sbjct: 730  YRHVHLMSKNGDQHPSATLFV 750


>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
          Length = 777

 Score =  241 bits (614), Expect = 4e-63
 Identities = 150/395 (37%), Positives = 221/395 (55%), Gaps = 22/395 (5%)

Query: 67  IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
           I +I+E+R G  ++  E+  A    ED CF+I++  Q   +TL L A S  DA +W+ GL
Sbjct: 90  IEDIQEVRMGHRTEGLEKF-ARDVPEDRCFSIVFKDQ--RNTLDLIAPSPADAQHWVLGL 146

Query: 127 -KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKD 185
            KI+H    +      ++ W+   +   D+ + N +S +EL+  L  +N +V  + + + 
Sbjct: 147 HKIIHHSG-SMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YARK 204

Query: 186 KFVEIG-AHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLH 244
            F E   +  D L  E+   FYK  M  Q+  I   F + +               + + 
Sbjct: 205 IFRECDHSQTDSLEDEEIEAFYK--MLTQRVEIDRTFAEAAG----------SGETLSVD 252

Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304
               FL H+Q+E  A     +   + +  + +    A+  +  D FL YL S + S +  
Sbjct: 253 QLVTFLQHQQREEAAGPALALS--LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSL 310

Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364
            +  V  QDM  PLSHY +SSSHNTYL  DQL   SS EAYIR L  GCRC+ELDCWDGP
Sbjct: 311 AHRRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGP 369

Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424
           + +P+IYHG+T T+KI F DV++AI+D+AF  S +PVILS+E HC++EQQR MA+    +
Sbjct: 370 NQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAI 429

Query: 425 FGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLG 459
            G +LL +P +   + LPSP QL+ KI++K KKLG
Sbjct: 430 LGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLG 464



 Score =  147 bits (372), Expect = 5e-35
 Identities = 101/321 (31%), Positives = 159/321 (49%), Gaps = 28/321 (8%)

Query: 875  ILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLV 934
            +L P  +G P     +D  E      +++R    +   KE+ ++       +A ELSD+V
Sbjct: 466  LLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRV-QHKPKEDKLR-------LAQELSDMV 517

Query: 935  VYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQR 991
            +YCK       +        F E+ SF E +A  ++++     +++N   L+R+YP G R
Sbjct: 518  IYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWR 577

Query: 992  VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPM 1051
             DSSNY P  +W  G Q+VALNFQT    M +    F  NG  GYVL+P  +R    DP 
Sbjct: 578  TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR----DPN 633

Query: 1052 PPESQRKILM-------TLTVKVLGARHLPKLGR---SIACPFVEVEICGAEYDNNKFKT 1101
               + R +          L ++V+  + LPK+ +   SI  P V VEI G   D    +T
Sbjct: 634  GTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQT 693

Query: 1102 TVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSG 1161
             V+ +NG +P W     +  FE+  P+LA +RF+V + D  S  +F+  +T P+ ++K G
Sbjct: 694  AVITNNGFNPWW---DTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750

Query: 1162 FRSVPLKNGYSEDIELASLLV 1182
            +R V L +   +    A+L V
Sbjct: 751  YRHVHLMSKNGDQHPSATLFV 771


>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
          Length = 1002

 Score =  235 bits (599), Expect = 2e-61
 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%)

Query: 55  SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114
           S+ ++K +  +D   I ++  G+ S+ F R         CCFTI +G    + +L L   
Sbjct: 56  SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111

Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
           + E+A  W++GLK L      E   A      + W+++     D+     +++ E+  ++
Sbjct: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171

Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228
             +N  +   K ++  F E    +++  L+FE+F +FYK +            ++D  + 
Sbjct: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220

Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284
           +L  +D+ D              H   E  AQ L KV ++M     D   +  + F    
Sbjct: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265

Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337
                  L ++ F  ++ S    I++  +  V  QDM+ PL +Y+I+SSHNTYLTGDQL 
Sbjct: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324

Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397
           S+S  + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I  HAFV +
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384

Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456
            FPVILSIE HCS++QQR +A+  K +FGD L L+        QLPSP  L+ KI++K K
Sbjct: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444

Query: 457 KL-----GPRGDVDVNMEDKKDE 474
           KL         + +V+ ED  DE
Sbjct: 445 KLPYHLGDDAEEGEVSDEDSADE 467



 Score =  169 bits (427), Expect = 2e-41
 Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%)

Query: 922  KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
            K   +  ELSDLVVY    +  +D +++     + SF ET+A  +++QK    + YNQK 
Sbjct: 593  KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651

Query: 982  LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
            LTR+YP   R+DSSN++P   W  G Q+VALN+Q+  + MQ+N A F  NG  GYVL+P+
Sbjct: 652  LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711

Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089
             M    +     DP+P   ++++++    KV+  + LPK   S       I  PFVEVEI
Sbjct: 712  QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767

Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
             G   D  K +T VV+DNG +P+W   +E +TF ++ P +A +RF+V++ D     +F+ 
Sbjct: 768  IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823

Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
              T    ++  G+R V     Y E +  AS+ V
Sbjct: 824  QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851


>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
          Length = 1693

 Score =  235 bits (599), Expect = 2e-61
 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%)

Query: 55  SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114
           S+ ++K +  +D   I ++  G+ S+ F R         CCFTI +G    + +L L   
Sbjct: 56  SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111

Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
           + E+A  W++GLK L      E   A      + W+++     D+     +++ E+  ++
Sbjct: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171

Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228
             +N  +   K ++  F E    +++  L+FE+F +FYK +            ++D  + 
Sbjct: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220

Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284
           +L  +D+ D              H   E  AQ L KV ++M     D   +  + F    
Sbjct: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265

Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337
                  L ++ F  ++ S    I++  +  V  QDM+ PL +Y+I+SSHNTYLTGDQL 
Sbjct: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324

Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397
           S+S  + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I  HAFV +
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384

Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456
            FPVILSIE HCS++QQR +A+  K +FGD L L+        QLPSP  L+ KI++K K
Sbjct: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444

Query: 457 KL-----GPRGDVDVNMEDKKDE 474
           KL         + +V+ ED  DE
Sbjct: 445 KLPYHLGDDAEEGEVSDEDSADE 467



 Score =  169 bits (427), Expect = 2e-41
 Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%)

Query: 922  KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
            K   +  ELSDLVVY    +  +D +++     + SF ET+A  +++QK    + YNQK 
Sbjct: 593  KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651

Query: 982  LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
            LTR+YP   R+DSSN++P   W  G Q+VALN+Q+  + MQ+N A F  NG  GYVL+P+
Sbjct: 652  LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711

Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089
             M    +     DP+P   ++++++    KV+  + LPK   S       I  PFVEVEI
Sbjct: 712  QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767

Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
             G   D  K +T VV+DNG +P+W   +E +TF ++ P +A +RF+V++ D     +F+ 
Sbjct: 768  IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823

Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
              T    ++  G+R V     Y E +  AS+ V
Sbjct: 824  QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851


>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
          Length = 1655

 Score =  235 bits (599), Expect = 2e-61
 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%)

Query: 55  SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114
           S+ ++K +  +D   I ++  G+ S+ F R         CCFTI +G    + +L L   
Sbjct: 38  SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 93

Query: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
           + E+A  W++GLK L      E   A      + W+++     D+     +++ E+  ++
Sbjct: 94  NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 153

Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228
             +N  +   K ++  F E    +++  L+FE+F +FYK +            ++D  + 
Sbjct: 154 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 202

Query: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284
           +L  +D+ D              H   E  AQ L KV ++M     D   +  + F    
Sbjct: 203 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 247

Query: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337
                  L ++ F  ++ S    I++  +  V  QDM+ PL +Y+I+SSHNTYLTGDQL 
Sbjct: 248 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 306

Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397
           S+S  + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I  HAFV +
Sbjct: 307 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 366

Query: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456
            FPVILSIE HCS++QQR +A+  K +FGD L L+        QLPSP  L+ KI++K K
Sbjct: 367 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 426

Query: 457 KL-----GPRGDVDVNMEDKKDE 474
           KL         + +V+ ED  DE
Sbjct: 427 KLPYHLGDDAEEGEVSDEDSADE 449



 Score =  171 bits (433), Expect = 4e-42
 Identities = 105/295 (35%), Positives = 161/295 (54%), Gaps = 33/295 (11%)

Query: 922  KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
            K   +  ELSDLVVY    +  +D +++     + SF ET+A  +++QK    + YNQK 
Sbjct: 575  KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 633

Query: 982  LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
            LTR+YP   R+DSSN++P   W  G Q+VALN+Q+  + MQ+N A F  NG  GYVL+P+
Sbjct: 634  LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 693

Query: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089
             M    +     DP+P   ++++++    KV+  + LPK   S       I  PFVEVEI
Sbjct: 694  QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 749

Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
             G   D  K +T VV+DNG +P+W   +E +TF ++ P +A +RF+V++ D     +F+ 
Sbjct: 750  IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 805

Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLR 1204
              T    ++  G+R V     Y E +  AS+ V   +        E+Y   RQL+
Sbjct: 806  QRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI-------NEIYGKNRQLQ 848


>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
          Length = 1416

 Score =  231 bits (590), Expect = 3e-60
 Identities = 146/430 (33%), Positives = 228/430 (53%), Gaps = 25/430 (5%)

Query: 52  VAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSL 111
           + W  +    +  + I  I+E+  G+ S+ F+R        +CCF+I +G+     +L L
Sbjct: 78  IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSH--RESLDL 135

Query: 112 AADSKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELK 167
            + S E A  W++GL+ L      E   A      + WL++     D+    S+S+ E+ 
Sbjct: 136 VSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVL 195

Query: 168 TILPLINFKVSSAKFLKDKFVEIGA--HKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225
            +L  +N  +   + +K  F E     H+  L FE+F  FYK +   +   +L       
Sbjct: 196 QLLHKLNVNLPRQR-VKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLL------- 247

Query: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFL 285
            +    + D  DA+++     QRFL  EQ+      L   ++ + +F +      ++  L
Sbjct: 248 MLTYSNHKDHLDAASL-----QRFLQVEQKMAGVT-LESCQDIIEQF-EPCPENKSKGLL 300

Query: 286 FVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
            +D F  Y  S    I++ ++  V  QDM  PLSHY+I+SSHNTYL GDQL S+S  + Y
Sbjct: 301 GIDGFTNYTRSPAGDIFNPEHHHVH-QDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359

Query: 346 IRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSI 405
              L+ GCRC+E+DCWDGPDG+P+++HG+T T+KI F DV++ I  +AF+ + +PVILSI
Sbjct: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419

Query: 406 EEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDV 464
           E HCSV QQ+ MA+   ++ GD L L+  +   A  LPSP  L+ KI++K KKL      
Sbjct: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479

Query: 465 DVNMEDKKDE 474
           D    +  DE
Sbjct: 480 DAEEGEVSDE 489



 Score =  169 bits (429), Expect = 1e-41
 Identities = 102/274 (37%), Positives = 154/274 (56%), Gaps = 25/274 (9%)

Query: 921  EKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQK 980
            +K   ++  LSDLV Y K  +     +E     ++ SF ETKA  I++QKP   L++NQ+
Sbjct: 617  KKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQ 676

Query: 981  GLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQP 1040
             L+R+YP   RVDSSNY+P   W  G QMVALN+Q+  + +Q+N A FS NG  GYVL+P
Sbjct: 677  QLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKP 736

Query: 1041 ESM-----RTEKYDPMPPESQRKILMTLTVKVLGARHLPK-----LG--RSIACPFVEVE 1088
              M          DP+P + +++    L ++++  + LPK     LG    I  PFVEVE
Sbjct: 737  GCMCQGVFNPNSEDPLPGQLKKQ----LVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVE 792

Query: 1089 ICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFL 1148
            I G   D ++ +T VV+DNG +P W   +E + F ++ P +A +RF+V++ D     +F+
Sbjct: 793  IIGLPVDCSREQTRVVDDNGFNPTW---EETLVFMVHMPEIALVRFLVWDHDPIG-RDFI 848

Query: 1149 AHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
               T    ++  G+R V     Y E +E AS+ V
Sbjct: 849  GQRTLAFSSMMPGYRHV-----YLEGMEEASIFV 877


>gi|19115964 phospholipase C delta 3 [Homo sapiens]
          Length = 789

 Score =  230 bits (586), Expect = 7e-60
 Identities = 139/418 (33%), Positives = 224/418 (53%), Gaps = 25/418 (5%)

Query: 67  IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
           +  I+ +R G  S+   R         C      G +     L LAA + E+A  W+ GL
Sbjct: 111 VQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRR---KNLDLAAPTAEEAQRWVRGL 167

Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA-KFLKD 185
             L       S    ++ W+   ++  D  + + +S +E+K++L ++N  ++    +L  
Sbjct: 168 TKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLF 227

Query: 186 KFVEIGAHKDELSFEQFHLFYKKLMFEQQ-KSILDEFKKDSSVFILGNTDRPDASAVYLH 244
           K  +  ++ D L   +   F ++L+   + + I  ++  +  V           SA  L 
Sbjct: 228 KECD-HSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVL----------SAPELL 276

Query: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304
           +F    + +Q E  A      +   T  +++T ++     + +D F+ YL S E +  D 
Sbjct: 277 EF----LEDQGEEGATLARAQQLIQTYELNETAKQ--HELMTLDGFMMYLLSPEGAALDN 330

Query: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364
            +  V  QDMN PL+HY+ISSSHNTYLT  Q+   SS EAY+R    GCRC+ELDCW+GP
Sbjct: 331 THTCV-FQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGP 389

Query: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424
            G+PVIYHG T T+KI F DVVQA++DHAF  S +PVILS+E HC +EQQ  MA+    +
Sbjct: 390 GGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTI 449

Query: 425 FGDLLLTKPTEA-SADQLPSPSQLREKIIIKHKKL-GPRGDVDVNMEDKKDEHKQQGE 480
            GD+L+T+  ++ + ++LPSP QL+ ++++K KKL   R +    + D+++E +   E
Sbjct: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEE 507



 Score =  155 bits (391), Expect = 3e-37
 Identities = 99/267 (37%), Positives = 146/267 (54%), Gaps = 14/267 (5%)

Query: 924  QSIAIELSDLVVYCKPTS-KTKDNLEN-PDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
            + I+ ELS L VYC  T  +T     N P   ++ S  E KA  +IR+     +++N + 
Sbjct: 522  KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581

Query: 982  LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
            LTRVYP G R++S+NY P  +W  G Q+VALNFQT    M +N   F +NG+ GYVL+P 
Sbjct: 582  LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641

Query: 1042 SMR--TEKYDPMPPESQRKILMTLTVKVLGARHLPKLG----RSIACPFVEVEICGAEYD 1095
             +R     +DP  P   R    TL+++VL A+ LPKL      SI  P V +EI G   D
Sbjct: 642  CLRQPDSTFDPEYPGPPR---TTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPAD 698

Query: 1096 NNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPI 1155
              + +T  V +NG +P W  T   + F++  P LA +RFVV + D  S  +F+   T P+
Sbjct: 699  CARQETDYVLNNGFNPRWGQT---LQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPL 755

Query: 1156 KAVKSGFRSVPLKNGYSEDIELASLLV 1182
             ++K G+R + L +     +  A+L +
Sbjct: 756  SSLKQGYRHIHLLSKDGASLSPATLFI 782


>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
          Length = 762

 Score =  219 bits (557), Expect = 2e-56
 Identities = 142/409 (34%), Positives = 217/409 (53%), Gaps = 19/409 (4%)

Query: 67  IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
           I +++ IR G +S +  R+ A     +  FTI++  +   S L L A+S E+A  W+ GL
Sbjct: 63  ISDVETIRNGHDS-ELLRSLAEELPLEQGFTIVFHGR--RSNLDLMANSVEEAQIWMRGL 119

Query: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186
           ++L     +      ++ WL       D+ +   +S +E++ +L L+N ++         
Sbjct: 120 QLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLF 179

Query: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246
                +    L  E+F  FYK L             K + V  L  +   D   + L +F
Sbjct: 180 QAADTSQSGTLEGEEFVQFYKALT------------KRAEVQELFESFSADGQKLTLLEF 227

Query: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306
             FL  EQ+E      +++   +    + +        L +D FL+YL S++  I++   
Sbjct: 228 LDFLQEEQKER--DCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPAC 285

Query: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366
             +  QDM  PL+HY+I SSHNTYL GDQL  +SS E YIR L+ GCRC+E+D WDGP G
Sbjct: 286 LPI-YQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG 344

Query: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
           +PV+YHG T T++I F DVV  +  +AF TS +PVILS+E HCS EQQ+ MA+   E+ G
Sbjct: 345 EPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILG 404

Query: 427 DLLLTKPTE-ASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDE 474
           + LL+   +     QLPSP +LR KI++K KKL    D++   E+ + E
Sbjct: 405 EQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPE 453



 Score =  160 bits (405), Expect = 7e-39
 Identities = 109/324 (33%), Positives = 166/324 (51%), Gaps = 17/324 (5%)

Query: 879  KQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCK 938
            +++ +P +E +   +E  FE     +E        +N  K  +    +   LS LV+Y K
Sbjct: 447  EEEAEPELEESELALESQFETEPEPQE-----QNLQNKDKKKKSKPILCPALSSLVIYLK 501

Query: 939  PTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSN 996
              S      + E+  F EI SF ETKA  +I++   + +++N   L+RVYP G R DSSN
Sbjct: 502  SVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSN 561

Query: 997  YDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--TEKYDPMPPE 1054
            Y+P  LW  G QMVA+N QTA   M +    F  NG  GYVL+P+ +R     + P  P 
Sbjct: 562  YNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPI 621

Query: 1055 SQRKILMTLTVKVLGARHLPKLGR----SIACPFVEVEICGAEYDNNKFKTTVVNDNGLS 1110
            S  K   TL ++V+  + LPK+ +    SI  P V+V+I G   D  + +T  V +NG +
Sbjct: 622  SPFK-AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFN 680

Query: 1111 PIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNG 1170
            P W  T   + F +  P LA LRFVV + D  S  +F+   T P   ++ G+R + L + 
Sbjct: 681  PYWGQT---LCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSK 737

Query: 1171 YSEDIELASLLVFCEMRPVLESEE 1194
                +  AS+ V+  ++  LE +E
Sbjct: 738  DGISLRPASIFVYICIQEGLEGDE 761


>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
          Length = 1127

 Score =  213 bits (541), Expect = 1e-54
 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%)

Query: 59  DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116
           D  +  +DI  IKE+R GKN+ D  R+  +  +  EDC F+++YG  +   +L L A+S 
Sbjct: 180 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 236

Query: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
           + A  W++GL+ L        + + +S   +  SW+ +    +D      I+L      +
Sbjct: 237 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 296

Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215
             +N  + ++K ++ KF E+   KD+           E FH       +++  + F   K
Sbjct: 297 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 355

Query: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275
             LD   KD  +F+               + ++ + H  +E   + ++K         + 
Sbjct: 356 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 390

Query: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335
           +     + +L +D F  YL S +  I+D ++  V  QDM  PLSHY+I+SSHNTYL  DQ
Sbjct: 391 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 449

Query: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395
            R  S    YIR L+MGCR +ELD WDGPD +PVIY G T T++I F  V+  I  +AF 
Sbjct: 450 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 509

Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455
            S +P+IL +E HCS++QQ+ M +  K++ GD L T         LPSP  L+ KI+IK 
Sbjct: 510 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 569

Query: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478
           KKL       + DV  ED+  E  Q+
Sbjct: 570 KKLSSNCSGVEGDVTDEDEGAEMSQR 595



 Score =  144 bits (362), Expect = 7e-34
 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%)

Query: 922  KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
            K   +  ELS+LV  CK     + + + +   + E+ SF E  A     + P D + YN+
Sbjct: 610  KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 669

Query: 980  KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
            + L RV+P   R+DSSN +P   W CG Q+VA+NFQT    M +N   F  NG  GYVL+
Sbjct: 670  RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 729

Query: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087
            P  MR E         D +P  S +     L +K++  ++ PK   S     +  P+V V
Sbjct: 730  PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785

Query: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147
            EI G   D  + +T  V+ NG +PI+    E   F+I  P LA +RFVV ++D   D  F
Sbjct: 786  EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 841

Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
            +   T P + +++G+R VPL++   E +  ASL V
Sbjct: 842  IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876


>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
          Length = 1001

 Score =  213 bits (541), Expect = 1e-54
 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%)

Query: 59  DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116
           D  +  +DI  IKE+R GKN+ D  R+  +  +  EDC F+++YG  +   +L L A+S 
Sbjct: 54  DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 110

Query: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
           + A  W++GL+ L        + + +S   +  SW+ +    +D      I+L      +
Sbjct: 111 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 170

Query: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215
             +N  + ++K ++ KF E+   KD+           E FH       +++  + F   K
Sbjct: 171 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 229

Query: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275
             LD   KD  +F+               + ++ + H  +E   + ++K         + 
Sbjct: 230 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 264

Query: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335
           +     + +L +D F  YL S +  I+D ++  V  QDM  PLSHY+I+SSHNTYL  DQ
Sbjct: 265 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 323

Query: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395
            R  S    YIR L+MGCR +ELD WDGPD +PVIY G T T++I F  V+  I  +AF 
Sbjct: 324 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 383

Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455
            S +P+IL +E HCS++QQ+ M +  K++ GD L T         LPSP  L+ KI+IK 
Sbjct: 384 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 443

Query: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478
           KKL       + DV  ED+  E  Q+
Sbjct: 444 KKLSSNCSGVEGDVTDEDEGAEMSQR 469



 Score =  144 bits (362), Expect = 7e-34
 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%)

Query: 922  KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
            K   +  ELS+LV  CK     + + + +   + E+ SF E  A     + P D + YN+
Sbjct: 484  KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 543

Query: 980  KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
            + L RV+P   R+DSSN +P   W CG Q+VA+NFQT    M +N   F  NG  GYVL+
Sbjct: 544  RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 603

Query: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087
            P  MR E         D +P  S +     L +K++  ++ PK   S     +  P+V V
Sbjct: 604  PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659

Query: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147
            EI G   D  + +T  V+ NG +PI+    E   F+I  P LA +RFVV ++D   D  F
Sbjct: 660  EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 715

Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
            +   T P + +++G+R VPL++   E +  ASL V
Sbjct: 716  IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750


>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
          Length = 1095

 Score =  199 bits (507), Expect = 1e-50
 Identities = 154/457 (33%), Positives = 232/457 (50%), Gaps = 41/457 (8%)

Query: 48  ETRQVAWSKTADKIE-GFLDIMEIKEIRPGKNSKDFERAKAVRQK-EDCCFTILYGTQFV 105
           + + + W  +   +E   LDI  IKEIR GKN++ F       Q  EDC F+IL+G  + 
Sbjct: 140 DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENY- 198

Query: 106 LSTLSLAADSKEDAVNWLSGLKILHQEAM--------NASTPTIIESWLRKQIYSVDQTR 157
             +L L A+S + A  W+SGL+ L   +         N +TP  +  WL K ++      
Sbjct: 199 -ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFM--WL-KTVFEAADVD 254

Query: 158 RNSISLRELKT-ILPLINFKVSSAKFLKDKFVEIGAHKDELSF----EQFHLFYKKLMFE 212
            N I L +    ++  +N  +  AK ++ KF EI   K++L+     E+F   + +L   
Sbjct: 255 GNGIMLEDTSVELIKQLNPTLKEAK-IRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR 313

Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQ-EHWAQDLNKVRERMTK 271
            +   L        V I  N +  DA+     D   FL  EQ   H  +D+     R  +
Sbjct: 314 PEVYFL-------LVQISKNKEYLDAN-----DLMLFLEAEQGVTHITEDICLDIIRRYE 361

Query: 272 FIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYL 331
             ++  ++    FL +D F  YL S E  I+D +   V  QDM  PLSHY+I++SHNTYL
Sbjct: 362 LSEEGRQKG---FLAIDGFTQYLLSSECDIFDPEQKKV-AQDMTQPLSHYYINASHNTYL 417

Query: 332 TGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKD 391
             DQ R  +    YIR L+MGCR +ELD  DG D +P++ +    TT + F  V++ I  
Sbjct: 418 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINK 477

Query: 392 HAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKI 451
            AFV S +P+IL +  HCS+ QQ+ MA+  K+VFG+ L T+    S   LPSP +L+  I
Sbjct: 478 FAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMI 537

Query: 452 IIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSID 488
           I+K KKL    DV   +E +  +  ++ E+    S+D
Sbjct: 538 IVKGKKLPSDPDV---LEGEVTDEDEEAEMSRRMSVD 571



 Score =  145 bits (367), Expect = 2e-34
 Identities = 106/333 (31%), Positives = 164/333 (49%), Gaps = 31/333 (9%)

Query: 864  PQGKNQKSFVFILEPKQQGDPPV--EFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921
            P  +  K  + +   K   DP V     TD  EE         E++ ++    N     +
Sbjct: 528  PSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEA--------EMSRRMSVDYNGE---Q 576

Query: 922  KNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
            K   +  ELSDLV  CK        L  ++ ++ E+ SF ET+A  I  + P D + YN+
Sbjct: 577  KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNK 636

Query: 980  KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
            K L+R+YP   R+DSSN +P   W CG Q+VA+NFQT    M ++   F  NG  GYVL+
Sbjct: 637  KFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLR 696

Query: 1040 PESMRTEKYDPMPPESQRKIL-----MTLTVKVLGARHLPK-----LGRSIACPFVEVEI 1089
            P  MR E        + + IL     + L +K++  ++ PK         +  P+V +EI
Sbjct: 697  PSIMRDEV--SYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 754

Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
             G   D ++ +T  V  N  +PI+  T E   F++  P LA +RFVV ++D   D  F+ 
Sbjct: 755  HGIPADCSEQRTKTVQQNSDNPIFDETFE---FQVNLPELAMIRFVVLDDDYIGD-EFIG 810

Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
              T P + ++ G+R VPL++   + +E  +L V
Sbjct: 811  QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 843


>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
          Length = 997

 Score =  199 bits (507), Expect = 1e-50
 Identities = 154/457 (33%), Positives = 232/457 (50%), Gaps = 41/457 (8%)

Query: 48  ETRQVAWSKTADKIE-GFLDIMEIKEIRPGKNSKDFERAKAVRQK-EDCCFTILYGTQFV 105
           + + + W  +   +E   LDI  IKEIR GKN++ F       Q  EDC F+IL+G  + 
Sbjct: 42  DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENY- 100

Query: 106 LSTLSLAADSKEDAVNWLSGLKILHQEAM--------NASTPTIIESWLRKQIYSVDQTR 157
             +L L A+S + A  W+SGL+ L   +         N +TP  +  WL K ++      
Sbjct: 101 -ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFM--WL-KTVFEAADVD 156

Query: 158 RNSISLRELKT-ILPLINFKVSSAKFLKDKFVEIGAHKDELSF----EQFHLFYKKLMFE 212
            N I L +    ++  +N  +  AK ++ KF EI   K++L+     E+F   + +L   
Sbjct: 157 GNGIMLEDTSVELIKQLNPTLKEAK-IRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR 215

Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQ-EHWAQDLNKVRERMTK 271
            +   L        V I  N +  DA+     D   FL  EQ   H  +D+     R  +
Sbjct: 216 PEVYFL-------LVQISKNKEYLDAN-----DLMLFLEAEQGVTHITEDICLDIIRRYE 263

Query: 272 FIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYL 331
             ++  ++    FL +D F  YL S E  I+D +   V  QDM  PLSHY+I++SHNTYL
Sbjct: 264 LSEEGRQKG---FLAIDGFTQYLLSSECDIFDPEQKKV-AQDMTQPLSHYYINASHNTYL 319

Query: 332 TGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKD 391
             DQ R  +    YIR L+MGCR +ELD  DG D +P++ +    TT + F  V++ I  
Sbjct: 320 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINK 379

Query: 392 HAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKI 451
            AFV S +P+IL +  HCS+ QQ+ MA+  K+VFG+ L T+    S   LPSP +L+  I
Sbjct: 380 FAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMI 439

Query: 452 IIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSID 488
           I+K KKL    DV   +E +  +  ++ E+    S+D
Sbjct: 440 IVKGKKLPSDPDV---LEGEVTDEDEEAEMSRRMSVD 473



 Score =  145 bits (367), Expect = 2e-34
 Identities = 106/333 (31%), Positives = 164/333 (49%), Gaps = 31/333 (9%)

Query: 864  PQGKNQKSFVFILEPKQQGDPPV--EFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921
            P  +  K  + +   K   DP V     TD  EE         E++ ++    N     +
Sbjct: 430  PSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEA--------EMSRRMSVDYNGE---Q 478

Query: 922  KNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
            K   +  ELSDLV  CK        L  ++ ++ E+ SF ET+A  I  + P D + YN+
Sbjct: 479  KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNK 538

Query: 980  KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
            K L+R+YP   R+DSSN +P   W CG Q+VA+NFQT    M ++   F  NG  GYVL+
Sbjct: 539  KFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLR 598

Query: 1040 PESMRTEKYDPMPPESQRKIL-----MTLTVKVLGARHLPK-----LGRSIACPFVEVEI 1089
            P  MR E        + + IL     + L +K++  ++ PK         +  P+V +EI
Sbjct: 599  PSIMRDEV--SYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656

Query: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
             G   D ++ +T  V  N  +PI+  T E   F++  P LA +RFVV ++D   D  F+ 
Sbjct: 657  HGIPADCSEQRTKTVQQNSDNPIFDETFE---FQVNLPELAMIRFVVLDDDYIGD-EFIG 712

Query: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
              T P + ++ G+R VPL++   + +E  +L V
Sbjct: 713  QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 745


>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
          Length = 2302

 Score =  187 bits (476), Expect = 4e-47
 Identities = 100/214 (46%), Positives = 139/214 (64%), Gaps = 7/214 (3%)

Query: 249  FLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDA 308
            FL++ Q EH   D  ++   + KF + ++    +  +  + F  +L  +EN         
Sbjct: 1332 FLVNCQGEHCTYD--EILSIIQKF-EPSISMCHQGLMSFEGFARFLMDKENFASKNDESQ 1388

Query: 309  VDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKP 368
             +++++  PLS+Y+I SSHNTYLTG QL+ ESS E Y + L  GCR +ELDCWDG DG P
Sbjct: 1389 ENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMP 1448

Query: 369  VIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDL 428
            +IYHG T TTKI F +VV+AI   AF+ S  P+I+SIE HCS+ QQR MA+ FK VFG+ 
Sbjct: 1449 IIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEK 1508

Query: 429  LLTK---PTEASAD-QLPSPSQLREKIIIKHKKL 458
            L+TK    T+ S D  LPSP QLR+K+++K+KKL
Sbjct: 1509 LVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKL 1542



 Score =  128 bits (322), Expect = 3e-29
 Identities = 82/252 (32%), Positives = 131/252 (51%), Gaps = 17/252 (6%)

Query: 939  PTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYD 998
            PT+     +  P    I S  E  A  + R+    L ++    L R YP   R+DSSN +
Sbjct: 1741 PTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPN 1800

Query: 999  PFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESM------RTEKYDPMP 1052
            P   WL G Q+VALN+QT D  + +N A+F  NG  GYVL+P  +        +K+ P+ 
Sbjct: 1801 PLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLE 1860

Query: 1053 P--ESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLS 1110
               +S    + +LT+ V G    P    S+  P +EV++ G   D+  F+T  ++ N L+
Sbjct: 1861 RDLDSMDPAVYSLTI-VSGQNVCP--SNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLN 1917

Query: 1111 PIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNG 1170
            P+W    E+  F ++  +L FLRF V E +  +     A    P+KA+K G+R + L+N 
Sbjct: 1918 PMW---NEQFLFHVHFEDLVFLRFAVVENNSSA---VTAQRIIPLKALKRGYRHLQLRNL 1971

Query: 1171 YSEDIELASLLV 1182
            ++E +E++SL +
Sbjct: 1972 HNEVLEISSLFI 1983


>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
          Length = 1194

 Score =  173 bits (438), Expect = 1e-42
 Identities = 146/429 (34%), Positives = 213/429 (49%), Gaps = 54/429 (12%)

Query: 65  LDIMEIKEIRPG---KNSKDFERAKAVRQKEDCC----FTILYGTQFV-LSTLSLAADSK 116
           L+   I  IR G   K+ K     +AV + E+        +  GT  V +S   + A++ 
Sbjct: 60  LECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENP 119

Query: 117 EDAVNWLSGLK-ILHQ-EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLIN 174
           E    W+ GL+ I+H   A N S  T ++    K  +  +   +  I +R +        
Sbjct: 120 EVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGK--IPVRSITRTFASGK 177

Query: 175 FKVSSAKFLKDKFVEIGAHKD----ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFIL 230
            +    + LK+  +  G + +      S+E+F+   +K+    +  I D FKK       
Sbjct: 178 TEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKIC--PRTDIEDLFKKI------ 229

Query: 231 GNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMR----ETAEP--- 283
            N D+ D   V       FL   Q++       ++ E +  F D        E  EP   
Sbjct: 230 -NGDKTDYLTV--DQLVSFLNEHQRDP------RLNEILFPFYDAKRAMQIIEMYEPDED 280

Query: 284 -----FLFVDEFLTYLFSRENSIWDEKYDAVDM-QDMNNPLSHYWISSSHNTYLTGDQLR 337
                 +  D F  YL S EN+      D +++ Q+M++PL+HY+ISSSHNTYLTG Q  
Sbjct: 281 LKKKGLISSDGFCRYLMSDENA--PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFG 338

Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGP--DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395
            +SS E Y + L  GCRC+ELDCWDG   D +P+I HG    T I F DV+QAIK+ AFV
Sbjct: 339 GKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFV 398

Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA----SADQLPSPSQLREKI 451
           TS +PVILS E HCS  QQ  M+K  +++FGDLLL +  E+        LPSP+ L+ KI
Sbjct: 399 TSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKI 458

Query: 452 IIKHKKLGP 460
           +IK+K+L P
Sbjct: 459 LIKNKRLKP 467



 Score =  125 bits (315), Expect = 2e-28
 Identities = 86/279 (30%), Positives = 147/279 (52%), Gaps = 23/279 (8%)

Query: 918  KYWEKNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLL 975
            KY     +I   LS ++ Y +P      ++  E      + SF E+     ++   ++ +
Sbjct: 553  KYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFV 612

Query: 976  KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTG 1035
             YN++ ++R+YPKG RVDSSNY P   W  G QMV+LN+QT D  MQ+N   F  NG  G
Sbjct: 613  NYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCG 672

Query: 1036 YVLQPESMR--TEKYDPMPPES-QRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEIC 1090
            Y+L+P+ MR     +DP         I  T +V+V+  + L   K+G      +VEV++ 
Sbjct: 673  YLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG-----TYVEVDMY 727

Query: 1091 GAEYD--NNKFKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNF 1147
            G   D    +F+T +V +NGL+P++   +E   F ++  P+LA LR  VY++    +   
Sbjct: 728  GLPTDTIRKEFRTRMVMNNGLNPVY--NEESFVFRKVILPDLAVLRIAVYDD----NNKL 781

Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEM 1186
            +     P+  +++G+R + L+N  ++ + L +  +FC +
Sbjct: 782  IGQRILPLDGLQAGYRHISLRNEGNKPLSLPT--IFCNI 818


>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
          Length = 1175

 Score =  173 bits (438), Expect = 1e-42
 Identities = 146/429 (34%), Positives = 213/429 (49%), Gaps = 54/429 (12%)

Query: 65  LDIMEIKEIRPG---KNSKDFERAKAVRQKEDCC----FTILYGTQFV-LSTLSLAADSK 116
           L+   I  IR G   K+ K     +AV + E+        +  GT  V +S   + A++ 
Sbjct: 60  LECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENP 119

Query: 117 EDAVNWLSGLK-ILHQ-EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLIN 174
           E    W+ GL+ I+H   A N S  T ++    K  +  +   +  I +R +        
Sbjct: 120 EVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGK--IPVRSITRTFASGK 177

Query: 175 FKVSSAKFLKDKFVEIGAHKD----ELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFIL 230
            +    + LK+  +  G + +      S+E+F+   +K+    +  I D FKK       
Sbjct: 178 TEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKIC--PRTDIEDLFKKI------ 229

Query: 231 GNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMR----ETAEP--- 283
            N D+ D   V       FL   Q++       ++ E +  F D        E  EP   
Sbjct: 230 -NGDKTDYLTV--DQLVSFLNEHQRDP------RLNEILFPFYDAKRAMQIIEMYEPDED 280

Query: 284 -----FLFVDEFLTYLFSRENSIWDEKYDAVDM-QDMNNPLSHYWISSSHNTYLTGDQLR 337
                 +  D F  YL S EN+      D +++ Q+M++PL+HY+ISSSHNTYLTG Q  
Sbjct: 281 LKKKGLISSDGFCRYLMSDENA--PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFG 338

Query: 338 SESSPEAYIRCLRMGCRCIELDCWDGP--DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395
            +SS E Y + L  GCRC+ELDCWDG   D +P+I HG    T I F DV+QAIK+ AFV
Sbjct: 339 GKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFV 398

Query: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEA----SADQLPSPSQLREKI 451
           TS +PVILS E HCS  QQ  M+K  +++FGDLLL +  E+        LPSP+ L+ KI
Sbjct: 399 TSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKI 458

Query: 452 IIKHKKLGP 460
           +IK+K+L P
Sbjct: 459 LIKNKRLKP 467



 Score =  125 bits (315), Expect = 2e-28
 Identities = 86/279 (30%), Positives = 147/279 (52%), Gaps = 23/279 (8%)

Query: 918  KYWEKNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLL 975
            KY     +I   LS ++ Y +P      ++  E      + SF E+     ++   ++ +
Sbjct: 553  KYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFV 612

Query: 976  KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTG 1035
             YN++ ++R+YPKG RVDSSNY P   W  G QMV+LN+QT D  MQ+N   F  NG  G
Sbjct: 613  NYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCG 672

Query: 1036 YVLQPESMR--TEKYDPMPPES-QRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEIC 1090
            Y+L+P+ MR     +DP         I  T +V+V+  + L   K+G      +VEV++ 
Sbjct: 673  YLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG-----TYVEVDMY 727

Query: 1091 GAEYD--NNKFKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNF 1147
            G   D    +F+T +V +NGL+P++   +E   F ++  P+LA LR  VY++    +   
Sbjct: 728  GLPTDTIRKEFRTRMVMNNGLNPVY--NEESFVFRKVILPDLAVLRIAVYDD----NNKL 781

Query: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEM 1186
            +     P+  +++G+R + L+N  ++ + L +  +FC +
Sbjct: 782  IGQRILPLDGLQAGYRHISLRNEGNKPLSLPT--IFCNI 818


>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
          Length = 608

 Score =  172 bits (435), Expect = 2e-42
 Identities = 112/341 (32%), Positives = 183/341 (53%), Gaps = 33/341 (9%)

Query: 154 DQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKD-ELSFEQFHLFYKKLMFE 212
           D  R   I+L + + +L  ++ + S    +K  F +    K   ++ E+F   Y+  +  
Sbjct: 12  DDFRGGKINLEKTQRLLEKLDIRCSYIH-VKQIFKDNDRLKQGRITIEEFRAIYR--IIT 68

Query: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVR--ERMT 270
            ++ I++ F          NT   +   +   +  +FL  EQ   +A +++K    E + 
Sbjct: 69  HREEIIEIF----------NTYSENRKILLASNLAQFLTQEQ---YAAEMSKAIAFEIIQ 115

Query: 271 KFIDDTMRETAEPF-LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNT 329
           K+  + + E  +   + ++ F  Y+ SRE  ++  +   V  QDM +PL+ Y+ISSSHNT
Sbjct: 116 KY--EPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKV-YQDMTHPLNDYFISSSHNT 172

Query: 330 YLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAI 389
           YL  DQL   S    Y+  L  GCRC+E+DCWDG   +PV+YHG+T T+K+ F  V+QAI
Sbjct: 173 YLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAI 232

Query: 390 KDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLRE 449
             +AF+TS +PV+LS+E HCS  QQ  MA   +  FG+ LL+   +   D LPSP  L+ 
Sbjct: 233 HKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKF 292

Query: 450 KIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQK 490
           KI++K+KK+G            K+ H+++G     D+ D++
Sbjct: 293 KILVKNKKIG----------TLKETHERKGSDKRGDNQDKE 323



 Score =  148 bits (374), Expect = 3e-35
 Identities = 93/263 (35%), Positives = 137/263 (52%), Gaps = 9/263 (3%)

Query: 926  IAIELSDLVVYCKPTSKTKDNLEN---PDFREIRSFVETKADSIIRQKPVDLLKYNQKGL 982
            IA+ LSDLV+Y K   K K    +     F E  S  ET+A  + + +  + + + +K +
Sbjct: 345  IALALSDLVIYTK-AEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFI 403

Query: 983  TRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPES 1042
            TR+YPK  R DSSN++P   W  G QMVALNFQT    M + +  F  NG +GY+L+P  
Sbjct: 404  TRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF 463

Query: 1043 MRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI--ACPFVEVEICGAEYDNNKFK 1100
            +R  K    P   +  + +TLT++++    LP    S       V +E+ G   D  K +
Sbjct: 464  LRESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQ 523

Query: 1101 TTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
            T V+  N  SP W    E  TF I+ P LA +RFVV  + + +   FL   T P+  +  
Sbjct: 524  TRVIKKNAFSPRW---NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNK 580

Query: 1161 GFRSVPLKNGYSEDIELASLLVF 1183
            G+R +PL +   E +E ASL V+
Sbjct: 581  GYRRIPLFSRMGESLEPASLFVY 603


>gi|12083581 phosphoinositide-specific phospholipase C beta 1
           isoform a [Homo sapiens]
          Length = 1216

 Score =  157 bits (398), Expect = 5e-38
 Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%)

Query: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
           VD F+ YL   EN +   EK D    +DM+ PLSHY+I+SSHNTYLT  QL   SS E Y
Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349

Query: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403
            + L  GCRC+ELDCW G   + +PVI HG+T TT+I F +V++AI + AF TS FP++L
Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409

Query: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457
           S E H  S +QQ  MA+  + +FGD LL +P E     S   LPSP  L  KI++K+KK
Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468



 Score =  156 bits (394), Expect = 1e-37
 Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%)

Query: 929  ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
            E+S+LV Y +P       +    N  F E+ SFVETK    + + PV+ ++YN+  L+R+
Sbjct: 539  EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597

Query: 986  YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
            YPKG RVDSSNY P   W  G QMVALNFQT D  MQ+N  ++  NG++GY L+PE MR 
Sbjct: 598  YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657

Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098
              + +DP        I+  TL+VK++  + L   K+G      +VEV++ G   D  +  
Sbjct: 658  PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712

Query: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157
            FKT     N ++P+W   +E + F ++  P LA LR  VYEE       F+ H   P++A
Sbjct: 713  FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766

Query: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187
            ++ G+  + L+N  ++ + L ++ V+ E++
Sbjct: 767  IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796


>gi|33356544 phosphoinositide-specific phospholipase C beta 1
           isoform b [Homo sapiens]
          Length = 1173

 Score =  157 bits (398), Expect = 5e-38
 Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%)

Query: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
           VD F+ YL   EN +   EK D    +DM+ PLSHY+I+SSHNTYLT  QL   SS E Y
Sbjct: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349

Query: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403
            + L  GCRC+ELDCW G   + +PVI HG+T TT+I F +V++AI + AF TS FP++L
Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409

Query: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457
           S E H  S +QQ  MA+  + +FGD LL +P E     S   LPSP  L  KI++K+KK
Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468



 Score =  156 bits (394), Expect = 1e-37
 Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%)

Query: 929  ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
            E+S+LV Y +P       +    N  F E+ SFVETK    + + PV+ ++YN+  L+R+
Sbjct: 539  EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597

Query: 986  YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
            YPKG RVDSSNY P   W  G QMVALNFQT D  MQ+N  ++  NG++GY L+PE MR 
Sbjct: 598  YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657

Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098
              + +DP        I+  TL+VK++  + L   K+G      +VEV++ G   D  +  
Sbjct: 658  PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712

Query: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157
            FKT     N ++P+W   +E + F ++  P LA LR  VYEE       F+ H   P++A
Sbjct: 713  FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766

Query: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187
            ++ G+  + L+N  ++ + L ++ V+ E++
Sbjct: 767  IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796


>gi|11386139 phospholipase C beta 3 [Homo sapiens]
          Length = 1234

 Score =  153 bits (387), Expect = 9e-37
 Identities = 101/278 (36%), Positives = 152/278 (54%), Gaps = 18/278 (6%)

Query: 929  ELSDLVVYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
            E+S LV Y +P    S       N  F E+ SFVETKA   + + P++ ++YN++ L+R+
Sbjct: 589  EMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRI 647

Query: 986  YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
            YPKG RVDSSNY P   W  G Q+VALNFQT D  MQ+N  +F  NGR+GY+L+PE MR 
Sbjct: 648  YPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRR 707

Query: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKT 1101
              + +DP        I+   L VKV+  + L      I   +VEV++ G   D   K++T
Sbjct: 708  PDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGI---YVEVDMFGLPVDTRRKYRT 764

Query: 1102 TVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
                 N  +P+W   +E   F ++  P LA LR   +EE       F+ H   P+ A++S
Sbjct: 765  RTSQGNSFNPVW--DEEPFDFPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRS 818

Query: 1161 GFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYS 1198
            G+  V L+N  ++ + L +LL++ E    +  + + Y+
Sbjct: 819  GYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYA 856



 Score =  148 bits (373), Expect = 4e-35
 Identities = 138/430 (32%), Positives = 202/430 (46%), Gaps = 61/430 (14%)

Query: 65  LDIMEIKEIRPGKNSKDFERAKAVRQK----------EDCCFTILYGTQFVLST-LSLAA 113
           LDI  I++ R G+ ++   +   +R+           E+   T++ G   V +  L+  A
Sbjct: 64  LDISSIRDTRTGRYAR-LPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMA 122

Query: 114 DSKEDAVNWLSGLKILHQE--AMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILP 171
              + A  W   L  L     A NAS  T +     K    V+Q  R  I ++ +  +  
Sbjct: 123 VQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGR--IPVKNILKMFS 180

Query: 172 LINFKVSSA------KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225
               +V +A      KF + + +      DE S E F  F  KL              D 
Sbjct: 181 ADKKRVETALESCGLKFNRSESIR----PDEFSLEIFERFLNKLCLRPDI--------DK 228

Query: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKV-----RERMTKFIDDTMRET 280
            +  +G   +P  +   L DF    I+++Q      LN+V     R    + + +   E 
Sbjct: 229 ILLEIGAKGKPYLTLEQLMDF----INQKQRD--PRLNEVLYPPLRPSQARLLIEKY-EP 281

Query: 281 AEPFLFVDE-----FLTYLFSRENSIWDEKYDAVDMQ-DMNNPLSHYWISSSHNTYLTGD 334
            + FL  D+     F  YL   EN I     +A+D+  DM  PLS Y+I+SSHNTYLT  
Sbjct: 282 NQQFLERDQMSMEGFSRYLGGEENGILP--LEALDLSTDMTQPLSAYFINSSHNTYLTAG 339

Query: 335 QLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDH 392
           QL   SS E Y + L  GCRC+ELD W G  P+ +P I HG+T TT++   DV++AI + 
Sbjct: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399

Query: 393 AFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQL 447
           AF TS +PVILS E H  S +QQ  MA+  + +FGD LL +P +    A    LPSP  L
Sbjct: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459

Query: 448 REKIIIKHKK 457
             +I++K+KK
Sbjct: 460 MGRILVKNKK 469


>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
          Length = 1185

 Score =  150 bits (380), Expect = 6e-36
 Identities = 79/152 (51%), Positives = 100/152 (65%), Gaps = 7/152 (4%)

Query: 313 DMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVI 370
           DM  PL+HY+I+SSHNTYLT  Q    SS E Y + L  GCRC+ELDCW G  PD +P+I
Sbjct: 313 DMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPII 372

Query: 371 YHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLL 429
            HG+T TT I F + ++AI + AF TS +P+ILS E H  S  QQ  MA+  + +FGD+L
Sbjct: 373 THGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDML 432

Query: 430 LTKPTE----ASADQLPSPSQLREKIIIKHKK 457
           LT+P E         LPSP  LR KI+IK+KK
Sbjct: 433 LTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK 464



 Score =  141 bits (355), Expect = 5e-33
 Identities = 96/267 (35%), Positives = 146/267 (54%), Gaps = 17/267 (6%)

Query: 929  ELSDLVVYCKPTSKTKDNLENPDFRE--IRSFVETKADSIIRQKPVDLLKYNQKGLTRVY 986
            E+S LV Y +PT            R   I SF E KA  ++ +  V  + YN++ ++R+Y
Sbjct: 545  EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIY 604

Query: 987  PKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR-- 1044
            PKG R+DSSNY P   W  G QMVALNFQT D  MQ N A+F  NG++GY+L+ E MR  
Sbjct: 605  PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRP 664

Query: 1045 TEKYDPMPPES-QRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKTT 1102
             ++++P   +     +  TL++ V+  + L +  RS+   +VEVE+ G   D   +++T 
Sbjct: 665  DKQFNPFSVDRIDVVVATTLSITVISGQFLSE--RSVR-TYVEVELFGLPGDPKRRYRTK 721

Query: 1103 V-VNDNGLSPIWAPTQEKVTFE-IYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
            +  + N ++P+W   +E   FE I  P LA LR  V EE       FL H   PI A+ S
Sbjct: 722  LSPSTNSINPVW--KEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNS 775

Query: 1161 GFRSVPLKNGYSEDIELASLLVFCEMR 1187
            G+  + L +  +  + + +L +F EM+
Sbjct: 776  GYHHLCLHSESNMPLTMPALFIFLEMK 802


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
           [Homo sapiens]
          Length = 593

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 68/240 (28%), Positives = 114/240 (47%), Gaps = 29/240 (12%)

Query: 531 KWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRS 590
           +WFH  +     AE LL      T G DG+FL R S++ P D+TLS  R+G V H +I++
Sbjct: 5   RWFHPNITG-VEAENLLL-----TRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQN 58

Query: 591 TMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFE---LRLTDPVPNPNPHESKPWY 647
           T +     Y L     F+++  L+Q+Y E H +  E     + L  P+   +P  S+ W+
Sbjct: 59  TGD----YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADP-TSERWF 113

Query: 648 YDSLSRGEAEDMLMRIPRDGAFLIRKREG-----------SDSYAITFRARGKVKHCRIN 696
           +  LS  EAE +L    + G+FL+R+ +             D    +   + KV H  I 
Sbjct: 114 HGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIR 173

Query: 697 RDGRHFVLGTSAYFESLVELVSYYEKH----SLYRKMRLRYPVTPELLERYNMERDINSL 752
                + +G    F+SL +LV +Y+K+    +L   ++L+ P+    +    +E  +  L
Sbjct: 174 CQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVREL 233



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 30/100 (30%), Positives = 52/100 (52%), Gaps = 7/100 (7%)

Query: 643 SKPWYYDSLSRGEAEDMLMRIPRDGAFLIR-KREGSDSYAITFRARGKVKHCRINRDGRH 701
           S+ W++ +++  EAE++L+    DG+FL R  +     + ++ R  G V H +I   G +
Sbjct: 3   SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDY 62

Query: 702 FVLGTSAYFESLVELVSYYEKHSLYRK------MRLRYPV 735
           + L     F +L ELV YY +H    K      + L+YP+
Sbjct: 63  YDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%)

Query: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692
           VP P  +  +PWY  ++ R +AE +++ R+  +  +L+R R + S  YAI+ +   + KH
Sbjct: 101 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 158

Query: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745
            +I  RDG  F +  +  F+SL+ELV YY+ HSL    R     L++P   PE       
Sbjct: 159 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 217

Query: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804
            R  NSL       + P  +  ++      A YD+ A+   ELS  +G ++   +K    
Sbjct: 218 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 264

Query: 805 GWWKGDYGTRIQQYFPSNYVED 826
           GWW+G+   R+  +FPS YVE+
Sbjct: 265 GWWRGEVNGRV-GWFPSTYVEE 285


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 27/202 (13%)

Query: 635 VPNPNPHESKPWYYDSLSRGEAE-DMLMRIPRDGAFLIRKR-EGSDSYAITFRARGKVKH 692
           VP P  +  +PWY  ++ R +AE +++ R+  +  +L+R R + S  YAI+ +   + KH
Sbjct: 661 VPKPVDYSCQPWYAGAMERLQAETELINRV--NSTYLVRHRTKESGEYAISIKYNNEAKH 718

Query: 693 CRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVT-PELLERYNM 745
            +I  RDG  F +  +  F+SL+ELV YY+ HSL    R     L++P   PE       
Sbjct: 719 IKILTRDG-FFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 777

Query: 746 ERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSK-EPG 804
            R  NSL       + P  +  ++      A YD+ A+   ELS  +G ++   +K    
Sbjct: 778 NRAGNSL-------LSPKVLGIAI------ARYDFCARDMRELSLLKGDVVKIYTKMSAN 824

Query: 805 GWWKGDYGTRIQQYFPSNYVED 826
           GWW+G+   R+  +FPS YVE+
Sbjct: 825 GWWRGEVNGRV-GWFPSTYVEE 845


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 56/190 (29%), Positives = 85/190 (44%), Gaps = 33/190 (17%)

Query: 640 PHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRINRD 698
           PH   PW++  + R +AE+ML +   DGAFLIR+ E +   ++++ +    V+H ++ RD
Sbjct: 57  PH---PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRD 113

Query: 699 GRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRM 758
           G          F SL ELV Y+   S+ R  ++               RDI  +      
Sbjct: 114 GAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQI-------------FLRDIEQV------ 154

Query: 759 YVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQY 818
                   P  P   V+AL+D+  +   EL F RG  IH +      WWKG    +    
Sbjct: 155 --------PQQP-TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGM- 204

Query: 819 FPSNYVEDIS 828
           FP NYV  ++
Sbjct: 205 FPRNYVTPVN 214



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 52/174 (29%), Positives = 82/174 (47%), Gaps = 25/174 (14%)

Query: 497 AIADAKLSFS-DDIEQTMEEEVPQDIPPTELHFGE-------------KWFHKKVEKRTS 542
           A AD +LSF   DI + + EE  Q+    EL+  +              WF  K+  R  
Sbjct: 11  ATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIP-RAK 69

Query: 543 AEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLT 602
           AE++L +        DG FL+RESE+ P D++LS      VQH ++   +  G  KY+L 
Sbjct: 70  AEEMLSKQ-----RHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDGAGKYFLW 121

Query: 603 DNLTFSSIYALIQHYRETHL-RCAEFELRLTDPVPNPNPHESKPWYYDSLSRGE 655
             + F+S+  L+ ++R T + R  +  LR  + VP    +    + +D    GE
Sbjct: 122 -VVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGE 174



 Score = 37.4 bits (85), Expect = 0.092
 Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 2/51 (3%)

Query: 776 ALYDYKAKRSDELSFCRGALIHNVSKE-PGGWWKGDYGTRIQQYFPSNYVE 825
           A YD+KA   DELSF RG ++  +++E    W+K +   +   + P NY+E
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGK-DGFIPKNYIE 54


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 28/205 (13%)

Query: 634 PVPNPNPHE----SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREG-SDSYAITFRARG 688
           P+  P   E    + PW+  ++ R +  D L++    G +LIR+R   ++ +AI+ +   
Sbjct: 647 PISRPPSREIDYTAYPWFAGNMERQQT-DNLLKSHASGTYLIRERPAEAERFAISIKFND 705

Query: 689 KVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPVTPELLERY 743
           +VKH ++        +  +  F+SL+ELV YY+ HSL    +     L+YP         
Sbjct: 706 EVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYK------- 758

Query: 744 NMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEP 803
           + ER  +     S ++  P  I       T  A Y++ A+   ELS   G ++   S+  
Sbjct: 759 SRERSASRASSRSPVFT-PRVIG------TAVARYNFAARDMRELSLREGDVVRIYSRIG 811

Query: 804 G--GWWKGDYGTRIQQYFPSNYVED 826
           G  GWWKG+   RI  +FPS YVE+
Sbjct: 812 GDQGWWKGETNGRI-GWFPSTYVEE 835


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 29/220 (13%)

Query: 634 PVPNPNPHE----SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREG-SDSYAITFRARG 688
           P+  P   E    + PW+  ++ R +  D L++    G +LIR+R   ++ +AI+ +   
Sbjct: 657 PISRPPSREIDYTAYPWFAGNMERQQT-DNLLKSHASGTYLIRERPAEAERFAISIKFND 715

Query: 689 KVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMR-----LRYPV-TPELLER 742
           +VKH ++        +  +  F+SL+ELV YY+ HSL    +     L+YP  + E    
Sbjct: 716 EVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSAS 775

Query: 743 YNMERDINSLYDVSRMYVDPSEIN-----PSMP---------QRTVKALYDYKAKRSDEL 788
               R   S    +  ++ P  ++     PS P           T  A Y++ A+   EL
Sbjct: 776 RASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMREL 835

Query: 789 SFCRGALIHNVSKEPG--GWWKGDYGTRIQQYFPSNYVED 826
           S   G ++   S+  G  GWWKG+   RI  +FPS YVE+
Sbjct: 836 SLREGDVVRIYSRIGGDQGWWKGETNGRI-GWFPSTYVEE 874


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 80/337 (23%), Positives = 138/337 (40%), Gaps = 90/337 (26%)

Query: 514 EEEV--PQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPN 571
           EEEV  P   PPT      +W+H K+++  + E+L Q       GK G++L+RES+  P 
Sbjct: 166 EEEVAIPLTAPPTN-----QWYHGKLDRTIAEERLRQ------AGKSGSYLIRESDRRPG 214

Query: 572 DYTLSFW-RSGRVQHCRIRST---------------------------MEGGTLKYYL-- 601
            + LSF  +   V H RI +                            ++G  L Y +  
Sbjct: 215 SFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAP 274

Query: 602 ---------------------TDNLTFSSIYALIQHYR-------ETHLRCAEFELRLTD 633
                                TD ++F      I H          T+LR  E  L + D
Sbjct: 275 PEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVED 334

Query: 634 PVPN----PNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARG 688
            V       +PHE K W++  +S+ EA ++LM + +  +FL+R  + +   Y++ FR   
Sbjct: 335 LVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNE 394

Query: 689 KVKHCRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMER 747
            ++  +I       F++G   Y+ S+ +++ +Y K  +     L+ PV  +     + E+
Sbjct: 395 NIQRFKICPTPNNQFMMG-GRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQ-----DQEQ 448

Query: 748 DINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKR 784
            +N         VD  EI  ++ ++T  A Y    K+
Sbjct: 449 VLNDT-------VDGKEIYNTIRRKTKDAFYKNIVKK 478



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 53/241 (21%), Positives = 102/241 (42%), Gaps = 36/241 (14%)

Query: 442 PSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADA 501
           P   + R + I+ + K+    ++     D    H +  + +MW             + + 
Sbjct: 277 PVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMW-------------VTNL 323

Query: 502 KLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTF 561
           +      I + + EEV ++  P   H G+ WFH K+ K+ +   L+      T G+  +F
Sbjct: 324 RTDEQGLIVEDLVEEVGREEDP---HEGKIWFHGKISKQEAYNLLM------TVGQVCSF 374

Query: 562 LVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETH 621
           LVR S+  P DY+L F  +  +Q  +I  T        ++     ++SI  +I HYR+  
Sbjct: 375 LVRPSDNTPGDYSLYFRTNENIQRFKICPTPN----NQFMMGGRYYNSIGDIIDHYRKEQ 430

Query: 622 LRCAEFELRLTDPVPNPNPHE------SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKRE 675
           +    +   L +PVP  +  +           Y+++ R   +     I + G +L++K +
Sbjct: 431 IVEGYY---LKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKG-YLLKKGK 486

Query: 676 G 676
           G
Sbjct: 487 G 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,169,104
Number of Sequences: 37866
Number of extensions: 2203431
Number of successful extensions: 6576
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 131
Number of HSP's that attempted gapping in prelim test: 5728
Number of HSP's gapped (non-prelim): 692
length of query: 1265
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1151
effective length of database: 13,930,794
effective search space: 16034343894
effective search space used: 16034343894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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