Guide to the Human Genome
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Search of human proteins with 239742600

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
         (1873 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]      3744   0.0  
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]      3744   0.0  
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]      3744   0.0  
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                   132   4e-30
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]        128   5e-29
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]        128   5e-29
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]            105   3e-22
gi|188219549 ankyrin repeat domain 32 [Homo sapiens]                   92   6e-18
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]        90   2e-17
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    86   3e-16
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ...    85   8e-16
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]    85   8e-16
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]    85   8e-16
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]    85   8e-16
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]     85   8e-16
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    82   4e-15
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       82   5e-15
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    82   6e-15
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     80   1e-14
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  80   2e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         79   3e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         79   3e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         79   3e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         79   3e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    79   3e-14
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]                    79   4e-14
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...    78   9e-14
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    78   9e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         78   9e-14
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...    78   9e-14

>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 3744 bits (9708), Expect = 0.0
 Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)

Query: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
            MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60

Query: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
            MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120

Query: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
            FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180

Query: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
            LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240

Query: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
            ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300

Query: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
            VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360

Query: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
            EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420

Query: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
            DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480

Query: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
            SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540

Query: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
            LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600

Query: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
            KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660

Query: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
            VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720

Query: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
            NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780

Query: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
            CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840

Query: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
            LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900

Query: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
            DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960

Query: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
            VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020

Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
            ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080

Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
            LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140

Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
            PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200

Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
            IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260

Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
            ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320

Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
            RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380

Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
            ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440

Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
            LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500

Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
            CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560

Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
            KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620

Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
            KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680

Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
            TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740

Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
            IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800

Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
            PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860

Query: 1861 HWKFCVECEELTP 1873
            HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873


>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 3744 bits (9708), Expect = 0.0
 Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)

Query: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
            MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60

Query: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
            MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120

Query: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
            FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180

Query: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
            LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240

Query: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
            ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300

Query: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
            VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360

Query: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
            EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420

Query: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
            DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480

Query: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
            SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540

Query: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
            LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600

Query: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
            KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660

Query: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
            VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720

Query: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
            NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780

Query: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
            CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840

Query: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
            LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900

Query: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
            DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960

Query: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
            VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020

Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
            ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080

Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
            LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140

Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
            PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200

Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
            IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260

Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
            ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320

Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
            RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380

Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
            ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440

Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
            LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500

Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
            CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560

Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
            KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620

Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
            KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680

Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
            TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740

Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
            IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800

Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
            PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860

Query: 1861 HWKFCVECEELTP 1873
            HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873


>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 3744 bits (9708), Expect = 0.0
 Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)

Query: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60
            MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG
Sbjct: 1    MEEGVQAPDWDSDETVIEGSVTESDLEEKELPWRRLLFDQDASLKSEFSLHPDTRGMCKG 60

Query: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120
            MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS
Sbjct: 61   MPSPEIQLGFKLREDLQEQMNKNKMMPVLSEDTILQSQDETERNQALLQTRKNCSMFIGS 120

Query: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180
            FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS
Sbjct: 121  FRQSGLSLNHQNIEGPEAESPEVLPHIEKELSEGRDSPEVSLLSGTAITVSDTVAVKETS 180

Query: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240
            LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF
Sbjct: 181  LVEPEKILAAPNTFFEPRKEVTMTMTSEETKDEESSLETFVSALESLLTSPESTQEERLF 240

Query: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300
            ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK
Sbjct: 241  ELVSDFDRKELMNPLSDSLSSISIPLNSWSACHRDLLEDAKDDALPAELLEALNTLSEAK 300

Query: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360
            VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC
Sbjct: 301  VETICHRKEGGSSLIARNECLEVEFNTSQTNEDCTQIAETLQDPNPSGLQTLAHQNITSC 360

Query: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420
            EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE
Sbjct: 361  EPLSNKRNSNSVTNSSDQETACVLRRSSRLEKLKVSRDAKYSDHMYKMPEKILPKILGCE 420

Query: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480
            DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH
Sbjct: 421  DLTNNNSSAQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISLH 480

Query: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
            SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE
Sbjct: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540

Query: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
            LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM
Sbjct: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600

Query: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
            KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH
Sbjct: 601  KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660

Query: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720
            VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP
Sbjct: 661  VKVNKGSKASLFINKEDVYEYYQKDPKNTKFGKSKHKQSTLDQIYSTGLRKGNLHNVKDP 720

Query: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780
            NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL
Sbjct: 721  NTNVPKGIGRRKTQHKRTQVDDVDCNPRKILAVSPSRRINRLVTYQQHIPETHNDLPEEL 780

Query: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840
            CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL
Sbjct: 781  CEPSSLTLSSLRNGLDSSTEACSVSKEKHIQNLDLSDSQEVQCLELESVDQTEAVSFPGL 840

Query: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900
            LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN
Sbjct: 841  LLHKEIKLPVVTTDKQPHTLQEQHHVLYKSHENSNLVPKDERFNKWENSFLSFVKENSDN 900

Query: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960
            DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA
Sbjct: 901  DDDDDCSTSEKAITSKKVLCSTGGKKHYNFKENLTNKKEMGFQQFLLSEDHLSQENELKA 960

Query: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020
            VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE
Sbjct: 961  VSLTTLPEQEAVNFSYSDNAVISEHVANYEQCIFGPSFDHSNGNPEQNSLACMRTLLTHE 1020

Query: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080
            ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP
Sbjct: 1021 ASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVEKMAKNCDTERNYIDRDQKIIYSNEP 1080

Query: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140
            LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK
Sbjct: 1081 LSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHK 1140

Query: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200
            PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS
Sbjct: 1141 PGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGS 1200

Query: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260
            IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE
Sbjct: 1201 IDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE 1260

Query: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320
            ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE
Sbjct: 1261 ADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQE 1320

Query: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380
            RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA
Sbjct: 1321 RSRESLSVHQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKA 1380

Query: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440
            ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC
Sbjct: 1381 ERDDLAKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCRNVTSLPC 1440

Query: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500
            LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI
Sbjct: 1441 LSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWNYSQNTNI 1500

Query: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560
            CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ
Sbjct: 1501 CLNSEAVRRGEFSGNDMNSKQNGSDCTLDGFPKSRHSDGTEKNKLPSQPVAFIGQTEYSQ 1560

Query: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620
            KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR
Sbjct: 1561 KENDLTEATDKDHEFYVSSPVIGKLNISETASVLAENAAHPSNIICDQDLSNYDPKRGNR 1620

Query: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680
            KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD
Sbjct: 1621 KTSSQQSPTGASESLAHQGIAVLGSDTVHQMKPYLKKSVSVVPCADDSQISSSSGSGQQD 1680

Query: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740
            TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ
Sbjct: 1681 TIKKALNYSTAPKKKCIQIKDLILLGRINPGNNILEFKTQETTHKASILLNGKLKVESGQ 1740

Query: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800
            IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL
Sbjct: 1741 IYKNPVTWLKDLLGGNSYVTWNYAWSKVTYLGKELLRYVSEDAPILPEPNSVPQQYQPCL 1800

Query: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860
            PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ
Sbjct: 1801 PEVACLDDPVQEPNKSMFEKTKFGQGTSRESMQSSPRYLQINEILLISDQEFLPCHIMDQ 1860

Query: 1861 HWKFCVECEELTP 1873
            HWKFCVECEELTP
Sbjct: 1861 HWKFCVECEELTP 1873


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score =  132 bits (331), Expect = 4e-30
 Identities = 99/311 (31%), Positives = 147/311 (47%), Gaps = 43/311 (13%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++NKRN RGE++LH A  RG+   +K LI  GADVN+ D AGWT LHEA N G  D+  +
Sbjct: 160  KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKM 1266
            LL AGA+VN + +D   PLHDA  N H K  ++LL+ G NP Q ++K ++ L  A+   M
Sbjct: 220  LLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTM 279

Query: 1267 KELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDS---SSLSHQERSR 1323
              LL   G   +     +++   E  P+            DG   DS     L H+ ++ 
Sbjct: 280  VNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSV-----DGNNTDSEFEKGLKHKAKNP 334

Query: 1324 ESLSVHQTLSAILQDIEEKQE-------------YLLEFEIRNPEDAEQYIE--KMLKIK 1368
            E     Q  +A ++D  E  E             +LL+ + R    +  +I   KM    
Sbjct: 335  EP----QKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKS 390

Query: 1369 KIMDNVLAKQKAERDDLA---------------KKYRVSIESFKHGALREQLANLAARQK 1413
               +N +A +KA    L+               +K R+S  +   G+   + +N A +QK
Sbjct: 391  YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN-AKQQK 449

Query: 1414 SLLVVAKKQKK 1424
                V KK+KK
Sbjct: 450  EKNKVKKKRKK 460



 Score =  117 bits (293), Expect = 1e-25
 Identities = 83/230 (36%), Positives = 117/230 (50%), Gaps = 21/230 (9%)

Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
           +K    S  K K KVNK        RN  GE  +++AA+  DA  +   I +G +VN   
Sbjct: 147 QKGTPNSASKTKDKVNK--------RNERGETRLHRAAIRGDARRIKELISEGADVNVKD 198

Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           +AGWTALHEA   G+Y  A +LL  GA+VN KGL   TPLHDA  NGHYKV +LLL  G 
Sbjct: 199 FAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGG 258

Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKF 639
           +P   N  G+  L  A    M  LL       +   TS++ SS +  + ED      P F
Sbjct: 259 NPQQSNRKGETPLKVANSPTMVNLL-----LGKGTYTSSEESSTESSEEEDA-----PSF 308

Query: 640 SSKSHIWHVYNENSNRQKLEHVKVN-KGSKASLFINKEDVYEYYQKDPKN 688
           +  S +     ++   + L+H   N +  KA+  +  +D YE+ + D ++
Sbjct: 309 APSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPV--KDEYEFDEDDEQD 356



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 20/168 (11%)

Query: 1133 EKKEISHKPGMKAGRINKRNARGESQL----HLAVRRGNLPL-----VKALIESGADVNL 1183
            +K   + K G +  RI K     ++ L     L+  R   PL     V  L++  A+ + 
Sbjct: 70   QKDSDTEKQGPERKRIKKEPVTRKAGLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESA 129

Query: 1184 NDNAGWTPLHEASN----EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEI 1239
            N     TP H + +    +G+ +      K   KVN  N  G   LH A      +  + 
Sbjct: 130  NSPVDTTPKHPSQSTVCQKGTPN---SASKTKDKVNKRNERGETRLHRAAIRGDARRIKE 186

Query: 1240 LLQNGANPNQKDQKQKSALDEADD----EKMKELLRSYGAIETVNRDE 1283
            L+  GA+ N KD    +AL EA +    +  K+LL +   + T   D+
Sbjct: 187  LISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLDD 234


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score =  128 bits (322), Expect = 5e-29
 Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)

Query: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
            DN      N    +   +K+       +  ++NKRN RGE+ LH+A  RG++  VK LI 
Sbjct: 124  DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 183

Query: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
             GA+VN+ D AGWTPLHEA N G  D+   L+ AGA VN + +D   PLHD+ ++ H   
Sbjct: 184  LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 243

Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
             ++LL++G NP Q ++  +  +D A+ E+++ LL+          SY   E         
Sbjct: 244  VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303

Query: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
                  +  E D+++ E    + SK       D+            K ID   +  +E+ 
Sbjct: 304  VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 363

Query: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
            +E+    +      +  +EK  Y   F+ +  +         E   E+ L+ KKI  +  
Sbjct: 364  KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 421

Query: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
               +    D+   K+Y VS E  + G ++ +L N    +++  +  +K+ K + +I N  
Sbjct: 422  VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 481

Query: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
              T L C    K             ++ TSL +L H  +G     S  + E Q    T  
Sbjct: 482  VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 535

Query: 1494 YSQNTNICLN 1503
              ++T  CL+
Sbjct: 536  KQEHTKTCLS 545



 Score =  104 bits (260), Expect = 7e-22
 Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)

Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
           +K    S  ++K KVNK        RN  GE  ++ AA+  D   V   I  G NVN   
Sbjct: 141 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 192

Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           +AGWT LHEA   G+Y  A  L+  GADVN +GL   TPLHD+  +GH  + +LLL +G 
Sbjct: 193 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 252

Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
           +P   N  G+  +D A+   ++ LL+R +P     +    S +  S++P  +++
Sbjct: 253 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 306


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score =  128 bits (322), Expect = 5e-29
 Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)

Query: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
            DN      N    +   +K+       +  ++NKRN RGE+ LH+A  RG++  VK LI 
Sbjct: 147  DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206

Query: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
             GA+VN+ D AGWTPLHEA N G  D+   L+ AGA VN + +D   PLHD+ ++ H   
Sbjct: 207  LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266

Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
             ++LL++G NP Q ++  +  +D A+ E+++ LL+          SY   E         
Sbjct: 267  VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326

Query: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
                  +  E D+++ E    + SK       D+            K ID   +  +E+ 
Sbjct: 327  VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386

Query: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
            +E+    +      +  +EK  Y   F+ +  +         E   E+ L+ KKI  +  
Sbjct: 387  KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444

Query: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
               +    D+   K+Y VS E  + G ++ +L N    +++  +  +K+ K + +I N  
Sbjct: 445  VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504

Query: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
              T L C    K             ++ TSL +L H  +G     S  + E Q    T  
Sbjct: 505  VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558

Query: 1494 YSQNTNICLN 1503
              ++T  CL+
Sbjct: 559  KQEHTKTCLS 568



 Score =  104 bits (260), Expect = 7e-22
 Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)

Query: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
           +K    S  ++K KVNK        RN  GE  ++ AA+  D   V   I  G NVN   
Sbjct: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215

Query: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           +AGWT LHEA   G+Y  A  L+  GADVN +GL   TPLHD+  +GH  + +LLL +G 
Sbjct: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275

Query: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
           +P   N  G+  +D A+   ++ LL+R +P     +    S +  S++P  +++
Sbjct: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329


>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
          Length = 777

 Score =  105 bits (263), Expect = 3e-22
 Identities = 62/162 (38%), Positives = 88/162 (54%), Gaps = 9/162 (5%)

Query: 1118 NMSKELANISK------LSQREKKEISHKPGMKAGRIN---KRNARGESQLHLAVRRGNL 1168
            NMS E  ++S       LS    + +   P       N   KRN RGE+ LH+A  +G++
Sbjct: 382  NMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDI 441

Query: 1169 PLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDA 1228
            P V+ L+++G+D N+ D+AGWTPLHEA N G + ++  LL+  A VN        PLHDA
Sbjct: 442  PSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDA 501

Query: 1229 VANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
              N H+   ++LL  GA+ N  +      +D  DDE MK LL
Sbjct: 502  AKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 46/121 (38%), Positives = 62/121 (51%)

Query: 484 RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
           +RN  GE L++ A++  D   V + ++ G + N   +AGWT LHEA   G  +    LL+
Sbjct: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482

Query: 544 GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRL 603
             A VN  G    +PLHDA  NGH  + +LLL  GA     N  G   +D   D  MK L
Sbjct: 483 HKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSL 542

Query: 604 L 604
           L
Sbjct: 543 L 543


>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
          Length = 1058

 Score = 91.7 bits (226), Expect = 6e-18
 Identities = 57/169 (33%), Positives = 95/169 (56%), Gaps = 9/169 (5%)

Query: 1118 NMSKELANISKLSQREKKEISHKPG-----MKAGRINKRNARGESQLHLAVRRGNLP-LV 1171
            N++K  +++ KL ++ + E+S         +K    +K N +GE+ LH A     +  L+
Sbjct: 765  NLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLI 824

Query: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN-CENIDGILPLHDAVA 1230
              L   G D+N+ DNAGWTPLHEA N G+   + E+L+   +V+    +DG+ PLHDA++
Sbjct: 825  LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884

Query: 1231 NNHLKAAEILLQNGANP--NQKDQKQKSALDEADDEKMKELLRSYGAIE 1277
            N H++  ++LLQ+G      Q++ K +  LD     ++KE L +   IE
Sbjct: 885  NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIE 933



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 7/124 (5%)

Query: 474 VNKISLHSINRRNIFGENLVYKAALHDDAD-LVHHCIKKGGNVNQPSYAGWTALHEASVG 532
           V K++ H   + N+ GE  +++A +++  + L+      G ++N    AGWT LHEA   
Sbjct: 795 VKKMNFH---KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNY 851

Query: 533 GFYRTASELLKGGADVNIKGLYQ-ITPLHDAVMNGHYKVAELLLLNGADPLF--RNDDGK 589
           G      E+L+   +V++      +TPLHDA+ NGH ++ +LLL +G   L   RN  G+
Sbjct: 852 GNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGE 911

Query: 590 CALD 593
             LD
Sbjct: 912 LPLD 915


>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
          Length = 1378

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 47/261 (18%)

Query: 1007 QNSLAC----MRTLLTHEASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVE-KMAKNC 1061
            Q +L+C     R  L  +  +  + V+L  +PQ+    AP     +T+T + E  +A++ 
Sbjct: 415  QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQE----AP-----ETETRLRELSVAEDE 465

Query: 1062 DTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSK 1121
            D E              E  +  A S+ +E  +VE                   TD ++ 
Sbjct: 466  DEEEEA-----------EEAAATAESEALEAGEVELSE------------GEDDTDGLTP 502

Query: 1122 ELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADV 1181
            +L    +L         H    K  + N+RN  GE+ LH A   G L  V+ L+  G  +
Sbjct: 503  QLEEDEELQ-------GHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555

Query: 1182 NLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN---CENIDGILPLHDAVANNHLKAAE 1238
            N  D  GWTPLHEA N G ++I+  LL  GA V+    +  +GI PLHDA+   H + AE
Sbjct: 556  NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615

Query: 1239 ILLQNGANPNQKDQKQKSALD 1259
            +LL+ GA+   + +K  S L+
Sbjct: 616  LLLERGASVTLRTRKGLSPLE 636



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 8/139 (5%)

Query: 458 QIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQ 517
           Q+ ++E+  G   + K +K      NRRN  GE L+++A +      V   +++G  +N 
Sbjct: 503 QLEEDEELQGHLGRRKGSKW-----NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNP 557

Query: 518 PSYAGWTALHEASVGGFYRTASELLKGGA---DVNIKGLYQITPLHDAVMNGHYKVAELL 574
             Y GWT LHEA   G       LL  GA   D   +G   ITPLHDA+  GH++VAELL
Sbjct: 558 RDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELL 617

Query: 575 LLNGADPLFRNDDGKCALD 593
           L  GA    R   G   L+
Sbjct: 618 LERGASVTLRTRKGLSPLE 636


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
            sapiens]
          Length = 226

 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 49/130 (37%), Positives = 74/130 (56%), Gaps = 3/130 (2%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A   G+  +V+ L++ G  VN  D+AGW+PLH A++ G  +I+  LL  GA+VN  N
Sbjct: 44   LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
             +G  PLH A + N  + A +LL+ GANP+ KD  + +A+  A    + KM  +L  Y A
Sbjct: 104  QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163

Query: 1276 IETVNRDESD 1285
               +   E +
Sbjct: 164  STNIQDTEGN 173



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 51/140 (36%), Positives = 75/140 (53%), Gaps = 4/140 (2%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++  G S LH+A   G   +VKAL+  GA VN  +  G TPLH A+++   +I V L
Sbjct: 66   VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMK 1267
            L+ GA  + ++      +H A A  +LK   ILL   A+ N +D +  + L  A DE+  
Sbjct: 126  LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185

Query: 1268 E---LLRSYGA-IETVNRDE 1283
            E   LL S GA I   N++E
Sbjct: 186  EEAKLLVSQGASIYIENKEE 205



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 33/118 (27%), Positives = 63/118 (53%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K  ++N  N  G + LH A  +    +   L+E GA+ +  D+   T +H A+ +G++ +
Sbjct: 95   KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            I  LL   A  N ++ +G  PLH A     ++ A++L+  GA+   +++++K+ L  A
Sbjct: 155  IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)

Query: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
           N  +SGK E++K + ++  S+  R +      ++ A      ++V   ++ G  VN    
Sbjct: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71

Query: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           AGW+ LH A+  G       LL  GA VN       TPLH A     +++A +LL  GA+
Sbjct: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131

Query: 581 P 581
           P
Sbjct: 132 P 132



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 34/116 (29%), Positives = 57/116 (49%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           +N ++  G + ++ AA     ++V   + KG  VN  +  G T LH A+    +  A  L
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKD 597
           L+GGA+ + K  Y+ T +H A   G+ K+  +LL   A    ++ +G   L  A D
Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 3/143 (2%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTA 525
           +G+ E +K        +N  N  G   ++ AA  +  ++    ++ G N +   +   TA
Sbjct: 83  AGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATA 142

Query: 526 LHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
           +H A+  G  +    LL   A  NI+     TPLH A      + A+LL+  GA     N
Sbjct: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202

Query: 586 DDGKCALDEAK---DLCMKRLLE 605
            + K  L  AK    L +KR++E
Sbjct: 203 KEEKTPLQVAKGGLGLILKRMVE 225



 Score = 31.6 bits (70), Expect = 7.6
 Identities = 23/65 (35%), Positives = 29/65 (44%)

Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
           TALH A   G       LL+ G  VN K     +PLH A   G  ++ + LL  GA    
Sbjct: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101

Query: 584 RNDDG 588
            N +G
Sbjct: 102 VNQNG 106


>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
            sapiens]
          Length = 151

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 43/103 (41%), Positives = 64/103 (62%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A   G+  +V+ L++ G  VN  D+AGW+PLH A++ G  +I+  LL  GA+VN  N
Sbjct: 44   LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
             +G  PLH A + N  + A +LL+ GANP+ KD  + +A+  A
Sbjct: 104  QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)

Query: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
           N  +SGK E++K + ++  S+  R +      ++ A      ++V   ++ G  VN    
Sbjct: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71

Query: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           AGW+ LH A+  G       LL  GA VN       TPLH A     +++A +LL  GA+
Sbjct: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131

Query: 581 P 581
           P
Sbjct: 132 P 132



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 30/85 (35%), Positives = 47/85 (55%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++  G S LH+A   G   +VKAL+  GA VN  +  G TPLH A+++   +I V L
Sbjct: 66   VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125

Query: 1208 LKAGAKVNCENIDGILPLHDAVANN 1232
            L+ GA  + ++      +H A A +
Sbjct: 126  LEGGANPDAKDHYEATAMHRAAAKD 150



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 25/81 (30%), Positives = 42/81 (51%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           +N ++  G + ++ AA     ++V   + KG  VN  +  G T LH A+    +  A  L
Sbjct: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125

Query: 542 LKGGADVNIKGLYQITPLHDA 562
           L+GGA+ + K  Y+ T +H A
Sbjct: 126 LEGGANPDAKDHYEATAMHRA 146



 Score = 31.6 bits (70), Expect = 7.6
 Identities = 23/65 (35%), Positives = 29/65 (44%)

Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
           TALH A   G       LL+ G  VN K     +PLH A   G  ++ + LL  GA    
Sbjct: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101

Query: 584 RNDDG 588
            N +G
Sbjct: 102 VNQNG 106


>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
            +A R+      GE+ L  A R G   +V   +E+   DVN  DNAG+  LHEA   G ++
Sbjct: 1418 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1477

Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
            I+  LL+ GA VNC   DG  PLHDAV N+HL+   +LL  GA+P       ++ +    
Sbjct: 1478 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1537

Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
             E M++ L  Y   +   R++ DA
Sbjct: 1538 SELMEKFLTDY-LNDLQGRNDDDA 1560



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)

Query: 489  GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
            GE L+ +AA     ++V +C++ K  +VN    AG+ ALHEA   G+      LL+ GAD
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488

Query: 548  VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
            VN        PLHDAV N H ++  LLL  GADP      G+  +       M++ L  Y
Sbjct: 1489 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1548

Query: 608  I 608
            +
Sbjct: 1549 L 1549


>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
          Length = 1755

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
            +A R+      GE+ L  A R G   +V   +E+   DVN  DNAG+  LHEA   G ++
Sbjct: 1452 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1511

Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
            I+  LL+ GA VNC   DG  PLHDAV N+HL+   +LL  GA+P       ++ +    
Sbjct: 1512 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1571

Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
             E M++ L  Y   +   R++ DA
Sbjct: 1572 SELMEKFLTDY-LNDLQGRNDDDA 1594



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)

Query: 489  GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
            GE L+ +AA     ++V +C++ K  +VN    AG+ ALHEA   G+      LL+ GAD
Sbjct: 1463 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1522

Query: 548  VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
            VN        PLHDAV N H ++  LLL  GADP      G+  +       M++ L  Y
Sbjct: 1523 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1582

Query: 608  I 608
            +
Sbjct: 1583 L 1583


>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
          Length = 1703

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
            +A R+      GE+ L  A R G   +V   +E+   DVN  DNAG+  LHEA   G ++
Sbjct: 1400 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1459

Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
            I+  LL+ GA VNC   DG  PLHDAV N+HL+   +LL  GA+P       ++ +    
Sbjct: 1460 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1519

Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
             E M++ L  Y   +   R++ DA
Sbjct: 1520 SELMEKFLTDY-LNDLQGRNDDDA 1542



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)

Query: 489  GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
            GE L+ +AA     ++V +C++ K  +VN    AG+ ALHEA   G+      LL+ GAD
Sbjct: 1411 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1470

Query: 548  VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
            VN        PLHDAV N H ++  LLL  GADP      G+  +       M++ L  Y
Sbjct: 1471 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1530

Query: 608  I 608
            +
Sbjct: 1531 L 1531


>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 53/144 (36%), Positives = 76/144 (52%), Gaps = 2/144 (1%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG-ADVNLNDNAGWTPLHEASNEGSID 1202
            +A R+      GE+ L  A R G   +V   +E+   DVN  DNAG+  LHEA   G ++
Sbjct: 1418 EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN 1477

Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
            I+  LL+ GA VNC   DG  PLHDAV N+HL+   +LL  GA+P       ++ +    
Sbjct: 1478 IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH 1537

Query: 1263 DEKMKELLRSYGAIETVNRDESDA 1286
             E M++ L  Y   +   R++ DA
Sbjct: 1538 SELMEKFLTDY-LNDLQGRNDDDA 1560



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 1/121 (0%)

Query: 489  GENLVYKAALHDDADLVHHCIK-KGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGAD 547
            GE L+ +AA     ++V +C++ K  +VN    AG+ ALHEA   G+      LL+ GAD
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488

Query: 548  VNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERY 607
            VN        PLHDAV N H ++  LLL  GADP      G+  +       M++ L  Y
Sbjct: 1489 VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY 1548

Query: 608  I 608
            +
Sbjct: 1549 L 1549


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 46/125 (36%), Positives = 69/125 (55%), Gaps = 2/125 (1%)

Query: 1148 INKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
            IN R+ +G +   LHLA    NL + + L+E GADVN  D  G  PLH A++ G +DI  
Sbjct: 828  INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA 887

Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
             L+K    VN  +     PLH+A      +   +LL +GA+P  K+Q+ ++ LD A  + 
Sbjct: 888  LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947

Query: 1266 MKELL 1270
            ++ LL
Sbjct: 948  IRALL 952



 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 4/167 (2%)

Query: 1145 AGRINKRNARGE--SQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSID 1202
            A  +N ++  G   S LH A   G   +V+ L++ GA+V+  D+ G  PLH A + G  +
Sbjct: 204  AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAE 263

Query: 1203 IIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD 1262
            ++  LL  GA  N  +     PLH+A     +    +LLQ+GA+PN ++   KSALD AD
Sbjct: 264  VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323

Query: 1263 DEKMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGK 1309
                  L   Y   E +    S     EK+ A+ +  +  C   DG+
Sbjct: 324  PSAKAVLTGEYKKDELLEAARSGN--EEKLMALLTPLNVNCHASDGR 368



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 42/119 (35%), Positives = 67/119 (56%)

Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
            + R  + LHLA     + +V+ L++ GADV+  D  G  PLH A + G  ++   LLK G
Sbjct: 366  DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425

Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
            A VN  ++    PLH+A + N ++   +LL +GA+P   +   KSA+D A   +++E L
Sbjct: 426  ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 42/122 (34%), Positives = 68/122 (55%), Gaps = 2/122 (1%)

Query: 478 SLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFY 535
           S  ++N R++ G +   ++ AA ++   +V + +  G +V+     G   LH A   G Y
Sbjct: 671 SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHY 730

Query: 536 RTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
             A  L++ GA VN+  L++ TPLH+A   G Y++ +LLL +GADP  +N DG   LD  
Sbjct: 731 EVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV 790

Query: 596 KD 597
           K+
Sbjct: 791 KE 792



 Score = 74.7 bits (182), Expect = 8e-13
 Identities = 52/180 (28%), Positives = 89/180 (49%), Gaps = 12/180 (6%)

Query: 1105 SETIHNIDSHST----DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGE--SQ 1158
            +E +  I S ST     ++   L   SK    E    + K    +  +N R+  G   + 
Sbjct: 632  NEAVQQILSESTPIRTSDVDYRLLEASKAGDLE----TVKQLCSSQNVNCRDLEGRHSTP 687

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A     + +V+ L+  GADV+  D  G  PLH A + G  ++   L++ GA VN  +
Sbjct: 688  LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVAD 747

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD--EADDEKMKELLRSYGAI 1276
            +    PLH+A A    +  ++LL++GA+P +K++   + LD  +  D  +++LLR   A+
Sbjct: 748  LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAAL 807



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 50/148 (33%), Positives = 72/148 (48%), Gaps = 4/148 (2%)

Query: 481 SINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTA 538
           ++N +++ G     ++ AA     D+V H ++ G NV+     G   LH A   G     
Sbjct: 206 NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVV 265

Query: 539 SELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
           S LL  GAD N +  +  TPLH+A + G   V  +LL +GADP  RN DGK ALD A   
Sbjct: 266 SLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPS 325

Query: 599 CMKRLLERYIPKHQKCLTSAQRSSIDPL 626
               L   Y  K  + L +A+  + + L
Sbjct: 326 AKAVLTGEY--KKDELLEAARSGNEEKL 351



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 54/211 (25%), Positives = 93/211 (44%), Gaps = 9/211 (4%)

Query: 466 SGKKEKMKVN----KISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYA 521
           SG +EK+        ++ H+ + R       ++ AA ++   +V   ++ G +V+     
Sbjct: 345 SGNEEKLMALLTPLNVNCHASDGRK---STPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 401

Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           G   LH A   G Y     LLK GA VN   L+Q TPLH+A      +V  LLL +GADP
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461

Query: 582 LFRNDDGKCALDEAKDLCMKRLLERYIPKHQ--KCLTSAQRSSIDPLDIEDVYQHKKPKF 639
              N  GK A+D A    ++  L      H   +    A  + +      ++   K+P+ 
Sbjct: 462 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS 521

Query: 640 SSKSHIWHVYNENSNRQKLEHVKVNKGSKAS 670
              +    V + +  R+++  + + KG+  +
Sbjct: 522 HETALHCAVASLHPKRKQVTELLLRKGANVN 552



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 481 SINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTA 538
           +IN R+  G N   ++ AA +++ ++  + ++ G +VN     G   LH A+  G    A
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886

Query: 539 SELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
           + L+K    VN    +  TPLH+A   G  ++  LLL +GADP  +N +G+  LD A   
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946

Query: 599 CMKRLLERYIP 609
            ++ LL   +P
Sbjct: 947 DIRALLIDAMP 957



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 55/195 (28%), Positives = 92/195 (47%), Gaps = 13/195 (6%)

Query: 1156 ESQLHLAVRRGNLPLVKALIES-GADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            + +L  A R GN   + AL+     + + +D    TPLH A+    + I+  LL+ GA V
Sbjct: 336  KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADV 395

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE---LLR 1271
            + ++  G++PLH+A +  H +  E+LL++GA  N  D  Q + L EA  +   E   LL 
Sbjct: 396  HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 455

Query: 1272 SYGAIET-VNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSVHQ 1330
            S+GA  T VN     A+     P +R +   +            SL    R  +   V +
Sbjct: 456  SHGADPTLVNCHGKSAVDMAPTPELRERLTYE--------FKGHSLLQAAREADLAKVKK 507

Query: 1331 TLSAILQDIEEKQEY 1345
            TL+  + + ++ Q +
Sbjct: 508  TLALEIINFKQPQSH 522



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 50/197 (25%), Positives = 86/197 (43%), Gaps = 36/197 (18%)

Query: 1110 NIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLP 1169
            N++  + D M+  L   ++ +  +  E+ HK G K   +N  +  G++ LH A   G+L 
Sbjct: 550  NVNEKNKDFMTP-LHVAAERAHNDVMEVLHKHGAK---MNALDTLGQTALHRAALAGHLQ 605

Query: 1170 LVKALIESGADVNLNDNAGWTP--------------------------LHEASNEGSIDI 1203
              + L+  G+D ++    G+T                           L EAS  G ++ 
Sbjct: 606  TCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665

Query: 1204 IVELLKAGAKVNCENIDG--ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            + +L  +   VNC +++G    PLH A   N +   E LL +GA+ + KD+     L  A
Sbjct: 666  VKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA 724

Query: 1262 ---DDEKMKELLRSYGA 1275
                  ++ ELL  +GA
Sbjct: 725  CSYGHYEVAELLVRHGA 741



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 1156 ESQLHLAVRR---GNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGA 1212
            E+ LH AV         + + L+  GA+VN  +    TPLH A+     D++  L K GA
Sbjct: 523  ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582

Query: 1213 KVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            K+N  +  G   LH A    HL+   +LL  G++P+
Sbjct: 583  KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 26/73 (35%), Positives = 35/73 (47%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           ++KG NVN+ +    T LH A+          L K GA +N       T LH A + GH 
Sbjct: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHL 604

Query: 569 KVAELLLLNGADP 581
           +   LLL  G+DP
Sbjct: 605 QTCRLLLSYGSDP 617



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 45/188 (23%), Positives = 73/188 (38%), Gaps = 60/188 (31%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            ++ ++  G   LH A   G+  + + L++ GA VN  D   +TPLHEA+++  +++   L
Sbjct: 395  VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454

Query: 1208 LKAGAK---VNCENIDGI------------------------------------------ 1222
            L  GA    VNC     +                                          
Sbjct: 455  LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514

Query: 1223 ---------LPLHDAVANNHLK---AAEILLQNGANPNQKDQKQKSALDEADD---EKMK 1267
                       LH AVA+ H K     E+LL+ GAN N+K++   + L  A +     + 
Sbjct: 515  NFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVM 574

Query: 1268 ELLRSYGA 1275
            E+L  +GA
Sbjct: 575  EVLHKHGA 582



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 23/89 (25%), Positives = 45/89 (50%)

Query: 1133 EKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPL 1192
            ++K+++     K   +N++N    + LH+A  R +  +++ L + GA +N  D  G T L
Sbjct: 536  KRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL 595

Query: 1193 HEASNEGSIDIIVELLKAGAKVNCENIDG 1221
            H A+  G +     LL  G+  +  ++ G
Sbjct: 596  HRAALAGHLQTCRLLLSYGSDPSIISLQG 624



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 27/72 (37%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDE---ADD 1263
            LL+ GA VN +N D + PLH A    H    E+L ++GA  N  D   ++AL     A  
Sbjct: 544  LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603

Query: 1264 EKMKELLRSYGA 1275
             +   LL SYG+
Sbjct: 604  LQTCRLLLSYGS 615



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 28/94 (29%), Positives = 43/94 (45%), Gaps = 9/94 (9%)

Query: 486 NIFGENLVYKAALHDDADLVHHCI-----KKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           N+  +N  +   LH  A+  H+ +     K G  +N     G TALH A++ G  +T   
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
           LL  G+D +I  L   T    A   G+  V ++L
Sbjct: 610 LLSYGSDPSIISLQGFT----AAQMGNEAVQQIL 639



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 32/85 (37%), Positives = 43/85 (50%), Gaps = 4/85 (4%)

Query: 514 NVNQPSYAGWTALH--EASVGGFYRTASELL-KGGADVNIKGLYQITPLHDAVMNGHYKV 570
           N  QP  +  TALH   AS+    +  +ELL + GA+VN K    +TPLH A    H  V
Sbjct: 515 NFKQPQ-SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573

Query: 571 AELLLLNGADPLFRNDDGKCALDEA 595
            E+L  +GA     +  G+ AL  A
Sbjct: 574 MEVLHKHGAKMNALDTLGQTALHRA 598



 Score = 31.6 bits (70), Expect = 7.6
 Identities = 17/69 (24%), Positives = 32/69 (46%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N  +    + LH A ++G   L   L+  GAD  + +  G TPL  A+ +    ++++ 
Sbjct: 896  VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDA 955

Query: 1208 LKAGAKVNC 1216
            +   A   C
Sbjct: 956  MPPEALPTC 964


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 44/114 (38%), Positives = 72/114 (63%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++A G S LH A   G+L L+  L+E+ A V++ D+ G  PLH A+ +G ++ +  L
Sbjct: 42   VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            L+A A VN  ++DG +PLH A    H + +E+LLQ+ +NP   ++ +K+ LD A
Sbjct: 102  LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 47/204 (23%), Positives = 92/204 (45%), Gaps = 18/204 (8%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G + ++ AAL    +L+   ++    V+     G   LH A+  G       
Sbjct: 41  NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+  A VN   L    PLH A   GHY+V+E+LL + ++P   N   K  LD A +   
Sbjct: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKKPKFSSKSHIWHVYNENSNRQKLEH 660
            ++ +  +  H  C+   +  + DP D         P +++  H+     +N +R+ +  
Sbjct: 161 LKVAQLLLNSH-LCVALLEGEAKDPCD---------PNYTTPLHL---AAKNGHREVIRQ 207

Query: 661 -----VKVNKGSKASLFINKEDVY 679
                +++N+ +K    +++  +Y
Sbjct: 208 LLRAGIEINRQTKTGTALHEAALY 231



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 16/140 (11%)

Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAG--------WTPLHEASNEGSIDI 1203
            N   ++ L LA   G L + + L+ S   V L +            TPLH A+  G  ++
Sbjct: 145  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEAD- 1262
            I +LL+AG ++N +   G   LH+A      +   +LL+ G + N ++   ++ALD  + 
Sbjct: 205  IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263

Query: 1263 ------DEKMKELLRSYGAI 1276
                    ++K+LLR    I
Sbjct: 264  FTTSQASREIKQLLREASGI 283



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 23/67 (34%), Positives = 38/67 (56%), Gaps = 1/67 (1%)

Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           ++ AA +   +++   ++ G  +N+ +  G TALHEA++ G       LL+GG DVNI+ 
Sbjct: 193 LHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRN 251

Query: 553 LYQITPL 559
            Y  T L
Sbjct: 252 TYNQTAL 258



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 48/171 (28%), Positives = 77/171 (45%), Gaps = 19/171 (11%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI---- 1203
            +N  +  G+  LHLA + G+  + + L++  ++  L + A  TPL  A   G + +    
Sbjct: 108  VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167

Query: 1204 -----IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
                  V LL+  AK  C+  +   PLH A  N H +    LL+ G   N +  K  +AL
Sbjct: 168  LNSHLCVALLEGEAKDPCDP-NYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTAL 225

Query: 1259 DEADDEKMKELLRSY--GAIE-----TVNRDESDAIVNEKIPAVRSKRHKQ 1302
             EA      E++R    G ++     T N+   D IVN+   +  S+  KQ
Sbjct: 226  HEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALD-IVNQFTTSQASREIKQ 275



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)

Query: 518 PSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLN 577
           P+Y   T LH A+  G      +LL+ G ++N +     T LH+A + G  +V  LLL  
Sbjct: 187 PNYT--TPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEG 243

Query: 578 GADPLFRNDDGKCALD 593
           G D   RN   + ALD
Sbjct: 244 GVDVNIRNTYNQTALD 259



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 26/102 (25%), Positives = 47/102 (46%), Gaps = 5/102 (4%)

Query: 1143 MKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPL----HEASNE 1198
            ++AG    R  +  + LH A   G   +V+ L+E G DVN+ +    T L       +++
Sbjct: 209  LRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQ 268

Query: 1199 GSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEIL 1240
             S +I   L +A   +    +     LHD  A N ++A +++
Sbjct: 269  ASREIKQLLREASGILKVRALKDFWNLHDPTALN-VRAGDVI 309


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 45/122 (36%), Positives = 69/122 (56%), Gaps = 2/122 (1%)

Query: 478 SLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFY 535
           ++ S+N R+I G     ++ AA ++   +V + ++ G +V+     G   LH A   G Y
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572

Query: 536 RTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
             A  L+K GA VN+  L++ TPLH+A   G Y++ +LLL +GADP  +N DG   LD  
Sbjct: 573 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 632

Query: 596 KD 597
           KD
Sbjct: 633 KD 634



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 43/125 (34%), Positives = 68/125 (54%), Gaps = 2/125 (1%)

Query: 1148 INKRNARGE--SQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
            +N R+ +G   + LHLA    NL + + L++ GADVN  D  G  PLH A++ G +D+  
Sbjct: 670  VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729

Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
             L+K  A VN  +     PLH+A      +   +LL +GA+P  K+Q+ ++ LD    + 
Sbjct: 730  LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADD 789

Query: 1266 MKELL 1270
            +  LL
Sbjct: 790  VSALL 794



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 49/165 (29%), Positives = 79/165 (47%), Gaps = 4/165 (2%)

Query: 1147 RINKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDII 1204
            ++N R+  G     LH A   G   +V+ L+++GA+V   D+ G  PLH A + G  +++
Sbjct: 48   KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107

Query: 1205 VELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDE 1264
              LL+ GA  N  +     PLH+A     +    +LLQ+GA P  ++   ++ALD AD  
Sbjct: 108  NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167

Query: 1265 KMKELLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGK 1309
                L   Y   E +    S     EK+ A+ +  +  C   DG+
Sbjct: 168  AKAVLTGEYKKDELLESARSGN--EEKMMALLTPLNVNCHASDGR 210



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 44/133 (33%), Positives = 73/133 (54%), Gaps = 4/133 (3%)

Query: 1148 INKRNARGESQ--LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
            +N R+  G     LH A     + +V+ L++ GADV+  D  G  PLH A + G  ++  
Sbjct: 517  VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576

Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD--EADD 1263
             L+K GA VN  ++    PLH+A A    +  ++LLQ+GA+P +K++   + LD  +  D
Sbjct: 577  LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD 636

Query: 1264 EKMKELLRSYGAI 1276
              +++LLR   A+
Sbjct: 637  TDIQDLLRGDAAL 649



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 41/119 (34%), Positives = 65/119 (54%)

Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
            + R  + LHLA     + +V+ L++ GADV+  D     PLH A + G  ++   L+K G
Sbjct: 208  DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267

Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
            A VN  ++    PLH+A + N ++   +LL  GA+P   +   KSA+D A   ++KE L
Sbjct: 268  ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 5/156 (3%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGW 523
           +G  E++K   ++   +N R+  G     ++ AA     D+V + ++ G NV      G 
Sbjct: 34  NGDVERVK-RLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGL 92

Query: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
             LH A   G     + LL+ GAD N +  +  TPLH+A + G   V  +LL +GA+P  
Sbjct: 93  IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTI 152

Query: 584 RNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQ 619
           RN DG+ ALD A       L   Y  K  + L SA+
Sbjct: 153 RNTDGRTALDLADPSAKAVLTGEY--KKDELLESAR 186



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 10/214 (4%)

Query: 473 KVNKISL-HSINRRNIFGENL--VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEA 529
           +V K+S   ++N R+  G +   ++ AA +++ ++  + ++ G +VN     G   LH A
Sbjct: 660 RVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

Query: 530 SVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGK 589
           +  G    A+ L+K  A VN    +  TPLH+A   G  ++  LLL +GADP  +N +G+
Sbjct: 720 ASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ 779

Query: 590 CALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSI-----DPLDIEDVYQHKKPKFSSKSH 644
             LD      +  LL   +P     L S  +  +      P    D         SS S 
Sbjct: 780 TPLDLVSADDVSALLTAAMP--PSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSA 837

Query: 645 IWHVYNENSNRQKLEHVKVNKGSKASLFINKEDV 678
              + N + +  +L  V  + G++ +  + K++V
Sbjct: 838 ASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEV 871



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 49/162 (30%), Positives = 73/162 (45%), Gaps = 8/162 (4%)

Query: 466 SGKKEKMKVN----KISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYA 521
           SG +EKM        ++ H+ + R       ++ AA ++   +V   ++ G +V+     
Sbjct: 187 SGNEEKMMALLTPLNVNCHASDGRK---STPLHLAAGYNRVKIVQLLLQHGADVHAKDKG 243

Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
               LH A   G Y     L+K GA VN   L+Q TPLH+A      +V  LLL  GADP
Sbjct: 244 DLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP 303

Query: 582 LFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSI 623
              N   K A+D A    +K  L  Y  K    L +A+ + +
Sbjct: 304 TLLNCHNKSAIDLAPTPQLKERL-AYEFKGHSLLQAAREADV 344



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 45/139 (32%), Positives = 65/139 (46%), Gaps = 13/139 (9%)

Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
            +K++          +  R+  G   LH A   G+  +V  L+  GAD N  DN  +TPLH
Sbjct: 70   RKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 129

Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDG--ILPLHDAVANNHLKAAEILLQNGANPNQKD 1251
            EA+ +G ID+ + LL+ GA+    N DG   L L D  A   L              +KD
Sbjct: 130  EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL----------TGEYKKD 179

Query: 1252 QKQKSALDEADDEKMKELL 1270
            +  +SA    ++EKM  LL
Sbjct: 180  ELLESA-RSGNEEKMMALL 197



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 41/128 (32%), Positives = 68/128 (53%), Gaps = 4/128 (3%)

Query: 1156 ESQLHLAVRRGNLPLVKALIES-GADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            + +L  + R GN   + AL+     + + +D    TPLH A+    + I+  LL+ GA V
Sbjct: 178  KDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE---LLR 1271
            + ++   ++PLH+A +  H +  E+L+++GA  N  D  Q + L EA  +   E   LL 
Sbjct: 238  HAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297

Query: 1272 SYGAIETV 1279
            SYGA  T+
Sbjct: 298  SYGADPTL 305



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 1/102 (0%)

Query: 1170 LVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAV 1229
            + + L+  GA++N       TPLH AS +   D++  ++K  AKVN  +  G   LH A 
Sbjct: 382  ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 1230 ANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
               HL+   +LL  G +PN    +  +AL +  +E +++LL+
Sbjct: 442  YCGHLQTCRLLLSYGCDPNIISLQGFTAL-QMGNENVQQLLQ 482



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 14/200 (7%)

Query: 1072 QKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLSQ 1131
            +++ Y  +  S++  ++  + T+++K    HL  E + N     T   +   A  S   +
Sbjct: 324  ERLAYEFKGHSLLQAAREADVTRIKK----HLSLEMV-NFKHPQTHETALHCAAASPYPK 378

Query: 1132 REKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTP 1191
            R  K+I      K   IN++     + LH+A  + +  +V+ +++  A VN  DN G T 
Sbjct: 379  R--KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436

Query: 1192 LHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN--PNQ 1249
            LH A+  G +     LL  G   N  ++ G   L     N      + LLQ G +   ++
Sbjct: 437  LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSE 491

Query: 1250 KDQKQKSALDEADDEKMKEL 1269
             D++   A    D E +K+L
Sbjct: 492  ADRQLLEAAKAGDVETVKKL 511



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 30/97 (30%), Positives = 41/97 (42%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           ++KG N+N+ +    T LH AS          ++K  A VN       T LH A   GH 
Sbjct: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHL 446

Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLE 605
           +   LLL  G DP   +  G  AL    +   + L E
Sbjct: 447 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQE 483



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 25/72 (34%), Positives = 33/72 (45%), Gaps = 4/72 (5%)

Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
           D+V   +K    VN     G T+LH A+  G  +T   LL  G D NI  L   T    A
Sbjct: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT----A 469

Query: 563 VMNGHYKVAELL 574
           +  G+  V +LL
Sbjct: 470 LQMGNENVQQLL 481



 Score = 31.2 bits (69), Expect = 9.9
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 4/110 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRT---ASELLKGG 545
           G +L+  A   D   +  H   +  N   P     TALH A+   + +       LL+ G
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQ-THETALHCAAASPYPKRKQICELLLRKG 390

Query: 546 ADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           A++N K    +TPLH A    H  V E+++ + A     ++ G+ +L  A
Sbjct: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440



 Score = 31.2 bits (69), Expect = 9.9
 Identities = 18/69 (26%), Positives = 30/69 (43%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N  +    + LH A ++G   L   L+  GAD  L +  G TPL   S +    ++   
Sbjct: 738  VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAA 797

Query: 1208 LKAGAKVNC 1216
            +   A  +C
Sbjct: 798  MPPSALPSC 806


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 50/133 (37%), Positives = 78/133 (58%), Gaps = 4/133 (3%)

Query: 1140 KPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG 1199
            K G  AG    RNA     LHLA ++G+  +VK L++S A  N  D +G TPL  A + G
Sbjct: 765  KHGANAGA---RNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGG 821

Query: 1200 SIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD 1259
              +++  LL+ GA +N  N  G   LH+AV   H+   E+LL +GA+    +++Q++A+D
Sbjct: 822  HHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD 881

Query: 1260 EAD-DEKMKELLR 1271
             A+ + K+ ELL+
Sbjct: 882  CAEQNSKIMELLQ 894



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 49/158 (31%), Positives = 82/158 (51%), Gaps = 5/158 (3%)

Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
            +K ++  P    G +N  +  G S LH+A   G   L+  L++ GA+    +     PLH
Sbjct: 724  QKRLAKVPASGLG-VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLH 782

Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQK 1253
             A  +G   ++  LL + AK N +++ G  PL  A +  H +   +LLQ+GA+ N  + K
Sbjct: 783  LACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNK 842

Query: 1254 QKSALDEADDEK---MKELLRSYGA-IETVNRDESDAI 1287
              +AL EA  EK   + ELL  +GA ++ +N+ +  A+
Sbjct: 843  GNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAV 880



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 77/309 (24%), Positives = 121/309 (39%), Gaps = 62/309 (20%)

Query: 1101 NHLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRIN--------KRN 1152
            N  E E + + + H  D + K    +      EK        + +GR+N         R+
Sbjct: 409  NQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEK--------LVSGRLNDPSVVTPFSRD 460

Query: 1153 ARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG--SIDIIVELLKA 1210
             RG + LH+A   G   L+  L+  GA VN  D  G TPLH A  +G  S+ +++   KA
Sbjct: 461  DRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKA 520

Query: 1211 GAKV------------------------------NCE----NIDGILPLHDAVANNHLKA 1236
             A+V                              +C     N  G  PLH A    +   
Sbjct: 521  SAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGV 580

Query: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVR 1296
             E LLQNGA+   +++ +++ L  A + K+  ++ +Y       +  S+A      P   
Sbjct: 581  IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEA------PVQS 634

Query: 1297 SKRHKQCFCDDGKTIDSSSLSHQERSRES----LSVHQTLSAILQDIEEKQEYLLEFEIR 1352
             +R       +  T   SS+S   R  E+      V + L A+     E   YLLE+   
Sbjct: 635  PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEE 694

Query: 1353 NPEDAEQYI 1361
            + EDAE  +
Sbjct: 695  DLEDAEDTV 703



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 4/139 (2%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G + ++ AALH  ADL+   +K G N    +      LH A   G ++    LL   A  
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA---KDLCMKRLLE 605
           N K L   TPL  A   GH+++  LLL +GA     N+ G  AL EA   K + +  LL 
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863

Query: 606 RYIPKHQKCLTSAQRSSID 624
            +    Q  L   QR+++D
Sbjct: 864 LHGASVQ-VLNKRQRTAVD 881



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 28/81 (34%), Positives = 39/81 (48%)

Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
           G  VN  S  G + LH A++ G       LLK GA+   +   Q  PLH A   GH++V 
Sbjct: 734 GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793

Query: 572 ELLLLNGADPLFRNDDGKCAL 592
           + LL + A P  ++  G   L
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPL 814



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 30/103 (29%), Positives = 45/103 (43%)

Query: 473 KVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVG 532
           ++N  S+ +   R+  G   ++ AA+   A L+   + KG  VN   Y G T LH A   
Sbjct: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506

Query: 533 GFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLL 575
           G+      LL   A   ++     TPLH A   GH    + L+
Sbjct: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 12/104 (11%)

Query: 513 GNVNQPSYA--------GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVM 564
           G +N PS          G T LH A+V G       L+  GA VN    +  TPLH A  
Sbjct: 446 GRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQ 505

Query: 565 NGHYKVAELLLLNGADPLFRNDDGKCALDEA----KDLCMKRLL 604
            G+  V  LLL   A    ++++G   L  A     + C+K L+
Sbjct: 506 KGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 2/92 (2%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N++++ G   +  A      +LV   ++ G ++N  +  G TALHEA +         LL
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLL 863

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
             GA V +    Q T +  A  N   K+ ELL
Sbjct: 864 LHGASVQVLNKRQRTAVDCAEQNS--KIMELL 893


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/143 (34%), Positives = 79/143 (55%), Gaps = 1/143 (0%)

Query: 1120 SKELANISKLSQREKKEISHKPGM-KAGRINKRNARGESQLHLAVRRGNLPLVKALIESG 1178
            ++++    +L QR +   +   G  K   +N ++  G S LH A   GN  L+  L+E+ 
Sbjct: 13   AEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQ 72

Query: 1179 ADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAE 1238
            A V++ DN G  PLH A+ +G  + +  +LKAG+ VN  + +G +PLH A  + H   +E
Sbjct: 73   AAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSE 132

Query: 1239 ILLQNGANPNQKDQKQKSALDEA 1261
            +LLQ+ +NP   D   K+ LD A
Sbjct: 133  MLLQHQSNPCMVDNSGKTPLDLA 155



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 35/115 (30%), Positives = 60/115 (52%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G + ++ AAL+ + +L+   ++    V+     G   LH A+  G       
Sbjct: 41  NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           +LK G+ VNI       PLH A  +GHY V+E+LL + ++P   ++ GK  LD A
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA 155



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 41/136 (30%), Positives = 64/136 (47%), Gaps = 16/136 (11%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNL--------NDNAGWTPLHEASNEGSIDIIVE 1206
            G++ L LA   G + +V+ L+ S     L         D  G +PLH A+  G IDII  
Sbjct: 148  GKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRL 207

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALD------- 1259
            LL+AG  +N +   G   LH+A      +   +LL +G N + ++   ++ALD       
Sbjct: 208  LLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266

Query: 1260 EADDEKMKELLRSYGA 1275
                 ++K+LLR   A
Sbjct: 267  SQASREIKQLLREASA 282



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 38/155 (24%), Positives = 62/155 (40%), Gaps = 42/155 (27%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            ++ ++ +G   LH A  +G    +K ++++G+ VN+  + G  PLH A+  G  D+   L
Sbjct: 75   VDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEML 134

Query: 1208 L-------------KAGAKVNCE----------------------------NIDGILPLH 1226
            L             K    + CE                            + +G  PLH
Sbjct: 135  LQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLH 194

Query: 1227 DAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
             A  N H+    +LLQ G + N +  K  +AL EA
Sbjct: 195  LAAKNGHIDIIRLLLQAGIDIN-RQTKSGTALHEA 228



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 3/81 (3%)

Query: 513 GNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAE 572
           G+   P+  G + LH A+  G       LL+ G D+N +     T LH+A + G  +V  
Sbjct: 182 GDATDPN--GTSPLHLAAKNGHIDIIRLLLQAGIDIN-RQTKSGTALHEAALCGKTEVVR 238

Query: 573 LLLLNGADPLFRNDDGKCALD 593
           LLL +G +   RN   + ALD
Sbjct: 239 LLLDSGINAHVRNTYSQTALD 259


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N  N  G + LHL  + G++P+   LI+ G  V+     G+TPLH AS+ G+I ++  LL
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A VN +   G  PLH A    H     +LL+NGA+PN+      + L  A   K   
Sbjct: 722  QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778

Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
             +     ++ V  + S  +V++K        H+  F    +T+D   L   E   E L  
Sbjct: 779  YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826

Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
             +      +D++E++E LL+F  +  +  E     + +I   M   +  +  E++  +K+
Sbjct: 827  FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883

Query: 1389 Y 1389
            Y
Sbjct: 884  Y 884



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 38/102 (37%), Positives = 59/102 (57%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++N +    ++ LH A R G+  +VK L+E+ A+ NL   AG TPLH A+ EG ++ ++ 
Sbjct: 462  KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            LL+  A   C    G  PLH A     ++ AE+LL+  A+PN
Sbjct: 522  LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)

Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
            +++ + E++       G  N  + +G + LHLA + G+  +V  L+   A+ NL + +G 
Sbjct: 610  AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
            TPLH  + EG + +   L+K G  V+     G  PLH A    ++K  + LLQ+ A+ N 
Sbjct: 670  TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
            K +   S L +A  +   +    LL++  +   V+ D +  +      A+  +       
Sbjct: 730  KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783

Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
            D  K +   +       +  +S  +T+  IL   E++ E L+ F  E R+  D ++  E 
Sbjct: 784  DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
            +  + K +D V+      R   A    V I S
Sbjct: 844  LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 39/115 (33%), Positives = 64/115 (55%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K  + N R   G + LH+A ++ ++ +++ L+++GA ++    +G TPLH AS  G + I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            +  LL+ GA  N  N+    PLH A    H + A+ LLQN A  N K +  ++ L
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 39/107 (36%), Positives = 58/107 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A    NL + + L+  GA VN     G TPLH AS  G++ ++  LL  GA++
Sbjct: 206  GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
              +  D + PLH A  N H++ +EILL +GA    K +   S +  A
Sbjct: 266  ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 38/94 (40%), Positives = 55/94 (58%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A   G+LP+VK L++ GA  N+++    TPLH A+  G  ++   LL+  AKV
Sbjct: 404  GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            N +  D   PLH A    H    ++LL+N ANPN
Sbjct: 464  NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 37/101 (36%), Positives = 55/101 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            IN  N  G + LHLA + G++ +V  L+     +      G T LH A+  G  +++ EL
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  GA VN ++  G  PL+ A   NHL+  + LL+NGAN N
Sbjct: 98   VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 34/100 (34%), Positives = 51/100 (51%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+AV   NL +VK L+  G   +     G+TPLH A+ +  +++   LL
Sbjct: 563  NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            + G   N E++ G+ PLH A    H +   +LL   AN N
Sbjct: 623  QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 40/124 (32%), Positives = 61/124 (49%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+A R G++  V AL+E  A        G+TPLH A+  G + +   LL
Sbjct: 497  NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A  N    +G+ PLH AV +N+L   ++LL  G +P+       + L  A  +   E
Sbjct: 557  ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616

Query: 1269 LLRS 1272
            + RS
Sbjct: 617  VARS 620



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A   G+  + K L++ GA  N     G+TPLH A  +  + ++  LLK GA ++   
Sbjct: 342  LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
              G+ PLH A    HL   + LLQ GA+PN  + K ++ L  A      E  K LL++  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 1275 AIETVNRDE 1283
             +    +D+
Sbjct: 462  KVNAKAKDD 470



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 34/102 (33%), Positives = 53/102 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            +   +N     G + LH+A RRGN+ +V+ L++ GA +        TPLH A+  G + I
Sbjct: 228  RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
               LL  GA +  +  +G+ P+H A   +HL    +LLQ  A
Sbjct: 288  SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A ++  + + ++L++ G   N     G TPLH A+ EG  +++  LL   A  
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
            N  N  G+ PLH      H+  A++L+++G
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 29/92 (31%), Positives = 51/92 (55%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A R G++ + + L++ GA +      G +P+H A+    +D +  LL+  A+++   
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
            +D + PLH A    H + A++LL  GA PN +
Sbjct: 336  LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
           + K  K++V ++ L      N  G+N    ++ A  H++ D+V   + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
           +T LH A+       A  LL+ G   N + +  +TPLH A   GH ++  LLL   A+  
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
             N  G   L            E ++P      KH   + +  R    PL +   Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++ +G + L++A +  +L +VK L+E+GA+ N+    G+TPL  A  +G  +++  L
Sbjct: 104  VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  G K        +  LH A  N+  + A +LLQN  NP+
Sbjct: 164  INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 36/117 (30%), Positives = 58/117 (49%)

Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
            +G + LH+A + G + + + L+E  A  N     G TPLH A +  ++DI+  LL  G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
             +    +G  PLH A   N ++ A  LLQ G + N +  +  + L  A  E   E++
Sbjct: 595  PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/99 (33%), Positives = 54/99 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I  +   G S +H+A +  +L  V+ L++  A+++       TPLH A++ G   +   L
Sbjct: 298  IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            L  GAK N   ++G  PLH A   NH++  E+LL+ GA+
Sbjct: 358  LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 37/90 (41%), Positives = 45/90 (50%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           IK G  V+  +  G+T LH AS  G  +    LL+  ADVN K     +PLH A   GH 
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
            +  LLL NGA P   + DG   L  AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A R  +      L+++  + ++    G+TPLH A++  ++++   LL  GA VN   
Sbjct: 177  LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
             +GI PLH A    ++    +LL  GA    K + + + L  A      ++ E+L  +GA
Sbjct: 237  QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 30/84 (35%), Positives = 46/84 (54%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +++ ++    + +G +VN     G T LH AS  G       LL  GA +  K   +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           +TPLH A  NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G + ++ AA  D  D V   ++    ++  +    T LH A+  G +R A  LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
           N + L   TPLH A    H +V ELLL  GA      + G   L  A  +     +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 605 ER 606
           +R
Sbjct: 425 QR 426



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 34/107 (31%), Positives = 51/107 (47%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           IN  N  G N ++ A+      +V   + K   +   +  G TALH A++ G      EL
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
           +  GA+VN +     TPL+ A    H +V + LL NGA+     +DG
Sbjct: 98  VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 48/97 (49%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N R + G   ++ A   +   ++   +K G +++  + +G T LH AS  G       LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           + GA  N+  +   TPLH A   GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)

Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
           KK  ++V ++ L    SI+     G   ++ A+      +V + +++G + N  +    T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
            LH A+  G    A  LL+  A VN K     TPLH A   GH  + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)

Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           LH  A   HH      + KG   N  +  G+T LH A      R    LLK GA ++   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
              +TPLH A   GH  + + LL  GA P   N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 34/115 (29%), Positives = 52/115 (45%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  ++ G   ++ AA    A++V   + K  N N  + +G T LH  +  G    A  
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           L+K G  V+       TPLH A   G+ K+ + LL + AD   +   G   L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/90 (31%), Positives = 41/90 (45%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AAL    ++V   +  G NVN  S  G+T L+ A+          LL+ GA+ 
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
           N+      TPL  A+  GH  V   L+  G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)

Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
           G  +   +  G + +H A+ G        LL+  A+++   L  +TPLH A   GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
           ++LL  GA P  R  +G   L  A      R++E  + K    + +   S + PL +   
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413

Query: 632 YQH 634
             H
Sbjct: 414 MGH 416



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 29/93 (31%), Positives = 44/93 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AA     + V   ++K  +    +  G+T LH A+  G  R A  LL+  A  
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           N  G   +TPLH AV + +  + +LLL  G  P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 33/100 (33%), Positives = 42/100 (42%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA     ++V   ++   N N  + AG T LH A+  G   T   LL+  A         
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
            TPLH A   G  +VAELLL   A P     +G   L  A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 30/84 (35%), Positives = 38/84 (45%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +DD       ++   N +  S  G+T LH A+       A  LL  GA VN      
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           ITPLH A   G+  +  LLL  GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 38.5 bits (88), Expect = 0.062
 Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G   +Y AA  +  ++V   ++ G N N  +  G+T L  A   G     + 
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           L+  G     KG  ++  LH A  N   + A +LL N  +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199



 Score = 35.0 bits (79), Expect = 0.69
 Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  N+  E  ++ AA     ++  + ++    VN  +    T LH A+  G       
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+  A+ N+      TPLH A   GH +    LL   A        G   L  A     
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
            R+ E  + +      +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
           E + V ++ L+   S+N     G   ++ A+   +  +V   + +G  +   +    T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           H A+  G  R +  LL  GA +  K    ++P+H A    H     LLL   A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 24/86 (27%), Positives = 41/86 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ A+ + +  LV   ++   +VN  +  G++ LH+A+  G     + LLK GA  
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
           N       TPL  A   G+  V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N  N  G + LHL  + G++P+   LI+ G  V+     G+TPLH AS+ G+I ++  LL
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A VN +   G  PLH A    H     +LL+NGA+PN+      + L  A   K   
Sbjct: 722  QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778

Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
             +     ++ V  + S  +V++K        H+  F    +T+D   L   E   E L  
Sbjct: 779  YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826

Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
             +      +D++E++E LL+F  +  +  E     + +I   M   +  +  E++  +K+
Sbjct: 827  FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883

Query: 1389 Y 1389
            Y
Sbjct: 884  Y 884



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 38/102 (37%), Positives = 59/102 (57%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++N +    ++ LH A R G+  +VK L+E+ A+ NL   AG TPLH A+ EG ++ ++ 
Sbjct: 462  KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            LL+  A   C    G  PLH A     ++ AE+LL+  A+PN
Sbjct: 522  LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)

Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
            +++ + E++       G  N  + +G + LHLA + G+  +V  L+   A+ NL + +G 
Sbjct: 610  AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
            TPLH  + EG + +   L+K G  V+     G  PLH A    ++K  + LLQ+ A+ N 
Sbjct: 670  TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
            K +   S L +A  +   +    LL++  +   V+ D +  +      A+  +       
Sbjct: 730  KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783

Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
            D  K +   +       +  +S  +T+  IL   E++ E L+ F  E R+  D ++  E 
Sbjct: 784  DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
            +  + K +D V+      R   A    V I S
Sbjct: 844  LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 39/115 (33%), Positives = 64/115 (55%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K  + N R   G + LH+A ++ ++ +++ L+++GA ++    +G TPLH AS  G + I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            +  LL+ GA  N  N+    PLH A    H + A+ LLQN A  N K +  ++ L
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 39/107 (36%), Positives = 58/107 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A    NL + + L+  GA VN     G TPLH AS  G++ ++  LL  GA++
Sbjct: 206  GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
              +  D + PLH A  N H++ +EILL +GA    K +   S +  A
Sbjct: 266  ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 38/94 (40%), Positives = 55/94 (58%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A   G+LP+VK L++ GA  N+++    TPLH A+  G  ++   LL+  AKV
Sbjct: 404  GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            N +  D   PLH A    H    ++LL+N ANPN
Sbjct: 464  NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 37/101 (36%), Positives = 55/101 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            IN  N  G + LHLA + G++ +V  L+     +      G T LH A+  G  +++ EL
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  GA VN ++  G  PL+ A   NHL+  + LL+NGAN N
Sbjct: 98   VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 34/100 (34%), Positives = 51/100 (51%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+AV   NL +VK L+  G   +     G+TPLH A+ +  +++   LL
Sbjct: 563  NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            + G   N E++ G+ PLH A    H +   +LL   AN N
Sbjct: 623  QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 40/124 (32%), Positives = 61/124 (49%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+A R G++  V AL+E  A        G+TPLH A+  G + +   LL
Sbjct: 497  NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A  N    +G+ PLH AV +N+L   ++LL  G +P+       + L  A  +   E
Sbjct: 557  ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616

Query: 1269 LLRS 1272
            + RS
Sbjct: 617  VARS 620



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A   G+  + K L++ GA  N     G+TPLH A  +  + ++  LLK GA ++   
Sbjct: 342  LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
              G+ PLH A    HL   + LLQ GA+PN  + K ++ L  A      E  K LL++  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 1275 AIETVNRDE 1283
             +    +D+
Sbjct: 462  KVNAKAKDD 470



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 34/102 (33%), Positives = 53/102 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            +   +N     G + LH+A RRGN+ +V+ L++ GA +        TPLH A+  G + I
Sbjct: 228  RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
               LL  GA +  +  +G+ P+H A   +HL    +LLQ  A
Sbjct: 288  SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A ++  + + ++L++ G   N     G TPLH A+ EG  +++  LL   A  
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
            N  N  G+ PLH      H+  A++L+++G
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 29/92 (31%), Positives = 51/92 (55%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A R G++ + + L++ GA +      G +P+H A+    +D +  LL+  A+++   
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
            +D + PLH A    H + A++LL  GA PN +
Sbjct: 336  LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
           + K  K++V ++ L      N  G+N    ++ A  H++ D+V   + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
           +T LH A+       A  LL+ G   N + +  +TPLH A   GH ++  LLL   A+  
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
             N  G   L            E ++P      KH   + +  R    PL +   Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++ +G + L++A +  +L +VK L+E+GA+ N+    G+TPL  A  +G  +++  L
Sbjct: 104  VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  G K        +  LH A  N+  + A +LLQN  NP+
Sbjct: 164  INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 36/117 (30%), Positives = 58/117 (49%)

Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
            +G + LH+A + G + + + L+E  A  N     G TPLH A +  ++DI+  LL  G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
             +    +G  PLH A   N ++ A  LLQ G + N +  +  + L  A  E   E++
Sbjct: 595  PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/99 (33%), Positives = 54/99 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I  +   G S +H+A +  +L  V+ L++  A+++       TPLH A++ G   +   L
Sbjct: 298  IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            L  GAK N   ++G  PLH A   NH++  E+LL+ GA+
Sbjct: 358  LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 37/90 (41%), Positives = 45/90 (50%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           IK G  V+  +  G+T LH AS  G  +    LL+  ADVN K     +PLH A   GH 
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
            +  LLL NGA P   + DG   L  AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A R  +      L+++  + ++    G+TPLH A++  ++++   LL  GA VN   
Sbjct: 177  LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
             +GI PLH A    ++    +LL  GA    K + + + L  A      ++ E+L  +GA
Sbjct: 237  QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 30/84 (35%), Positives = 46/84 (54%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +++ ++    + +G +VN     G T LH AS  G       LL  GA +  K   +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           +TPLH A  NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G + ++ AA  D  D V   ++    ++  +    T LH A+  G +R A  LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
           N + L   TPLH A    H +V ELLL  GA      + G   L  A  +     +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 605 ER 606
           +R
Sbjct: 425 QR 426



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 34/107 (31%), Positives = 51/107 (47%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           IN  N  G N ++ A+      +V   + K   +   +  G TALH A++ G      EL
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
           +  GA+VN +     TPL+ A    H +V + LL NGA+     +DG
Sbjct: 98  VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 48/97 (49%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N R + G   ++ A   +   ++   +K G +++  + +G T LH AS  G       LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           + GA  N+  +   TPLH A   GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)

Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
           KK  ++V ++ L    SI+     G   ++ A+      +V + +++G + N  +    T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
            LH A+  G    A  LL+  A VN K     TPLH A   GH  + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)

Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           LH  A   HH      + KG   N  +  G+T LH A      R    LLK GA ++   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
              +TPLH A   GH  + + LL  GA P   N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 34/115 (29%), Positives = 52/115 (45%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  ++ G   ++ AA    A++V   + K  N N  + +G T LH  +  G    A  
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           L+K G  V+       TPLH A   G+ K+ + LL + AD   +   G   L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/90 (31%), Positives = 41/90 (45%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AAL    ++V   +  G NVN  S  G+T L+ A+          LL+ GA+ 
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
           N+      TPL  A+  GH  V   L+  G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)

Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
           G  +   +  G + +H A+ G        LL+  A+++   L  +TPLH A   GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
           ++LL  GA P  R  +G   L  A      R++E  + K    + +   S + PL +   
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413

Query: 632 YQH 634
             H
Sbjct: 414 MGH 416



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 29/93 (31%), Positives = 44/93 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AA     + V   ++K  +    +  G+T LH A+  G  R A  LL+  A  
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           N  G   +TPLH AV + +  + +LLL  G  P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 33/100 (33%), Positives = 42/100 (42%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA     ++V   ++   N N  + AG T LH A+  G   T   LL+  A         
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
            TPLH A   G  +VAELLL   A P     +G   L  A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 30/84 (35%), Positives = 38/84 (45%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +DD       ++   N +  S  G+T LH A+       A  LL  GA VN      
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           ITPLH A   G+  +  LLL  GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 38.5 bits (88), Expect = 0.062
 Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G   +Y AA  +  ++V   ++ G N N  +  G+T L  A   G     + 
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           L+  G     KG  ++  LH A  N   + A +LL N  +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199



 Score = 35.0 bits (79), Expect = 0.69
 Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  N+  E  ++ AA     ++  + ++    VN  +    T LH A+  G       
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+  A+ N+      TPLH A   GH +    LL   A        G   L  A     
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
            R+ E  + +      +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
           E + V ++ L+   S+N     G   ++ A+   +  +V   + +G  +   +    T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           H A+  G  R +  LL  GA +  K    ++P+H A    H     LLL   A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 24/86 (27%), Positives = 41/86 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ A+ + +  LV   ++   +VN  +  G++ LH+A+  G     + LLK GA  
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
           N       TPL  A   G+  V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N  N  G + LHL  + G++P+   LI+ G  V+     G+TPLH AS+ G+I ++  LL
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A VN +   G  PLH A    H     +LL+NGA+PN+      + L  A   K   
Sbjct: 722  QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778

Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
             +     ++ V  + S  +V++K        H+  F    +T+D   L   E   E L  
Sbjct: 779  YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826

Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
             +      +D++E++E LL+F  +  +  E     + +I   M   +  +  E++  +K+
Sbjct: 827  FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883

Query: 1389 Y 1389
            Y
Sbjct: 884  Y 884



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 38/102 (37%), Positives = 59/102 (57%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++N +    ++ LH A R G+  +VK L+E+ A+ NL   AG TPLH A+ EG ++ ++ 
Sbjct: 462  KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            LL+  A   C    G  PLH A     ++ AE+LL+  A+PN
Sbjct: 522  LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)

Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
            +++ + E++       G  N  + +G + LHLA + G+  +V  L+   A+ NL + +G 
Sbjct: 610  AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
            TPLH  + EG + +   L+K G  V+     G  PLH A    ++K  + LLQ+ A+ N 
Sbjct: 670  TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
            K +   S L +A  +   +    LL++  +   V+ D +  +      A+  +       
Sbjct: 730  KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783

Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
            D  K +   +       +  +S  +T+  IL   E++ E L+ F  E R+  D ++  E 
Sbjct: 784  DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
            +  + K +D V+      R   A    V I S
Sbjct: 844  LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 39/115 (33%), Positives = 64/115 (55%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K  + N R   G + LH+A ++ ++ +++ L+++GA ++    +G TPLH AS  G + I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            +  LL+ GA  N  N+    PLH A    H + A+ LLQN A  N K +  ++ L
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 39/107 (36%), Positives = 58/107 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A    NL + + L+  GA VN     G TPLH AS  G++ ++  LL  GA++
Sbjct: 206  GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
              +  D + PLH A  N H++ +EILL +GA    K +   S +  A
Sbjct: 266  ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 38/94 (40%), Positives = 55/94 (58%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A   G+LP+VK L++ GA  N+++    TPLH A+  G  ++   LL+  AKV
Sbjct: 404  GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            N +  D   PLH A    H    ++LL+N ANPN
Sbjct: 464  NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 37/101 (36%), Positives = 55/101 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            IN  N  G + LHLA + G++ +V  L+     +      G T LH A+  G  +++ EL
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  GA VN ++  G  PL+ A   NHL+  + LL+NGAN N
Sbjct: 98   VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 34/100 (34%), Positives = 51/100 (51%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+AV   NL +VK L+  G   +     G+TPLH A+ +  +++   LL
Sbjct: 563  NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            + G   N E++ G+ PLH A    H +   +LL   AN N
Sbjct: 623  QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 40/124 (32%), Positives = 61/124 (49%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+A R G++  V AL+E  A        G+TPLH A+  G + +   LL
Sbjct: 497  NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A  N    +G+ PLH AV +N+L   ++LL  G +P+       + L  A  +   E
Sbjct: 557  ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616

Query: 1269 LLRS 1272
            + RS
Sbjct: 617  VARS 620



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A   G+  + K L++ GA  N     G+TPLH A  +  + ++  LLK GA ++   
Sbjct: 342  LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
              G+ PLH A    HL   + LLQ GA+PN  + K ++ L  A      E  K LL++  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 1275 AIETVNRDE 1283
             +    +D+
Sbjct: 462  KVNAKAKDD 470



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 34/102 (33%), Positives = 53/102 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            +   +N     G + LH+A RRGN+ +V+ L++ GA +        TPLH A+  G + I
Sbjct: 228  RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
               LL  GA +  +  +G+ P+H A   +HL    +LLQ  A
Sbjct: 288  SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A ++  + + ++L++ G   N     G TPLH A+ EG  +++  LL   A  
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
            N  N  G+ PLH      H+  A++L+++G
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 29/92 (31%), Positives = 51/92 (55%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A R G++ + + L++ GA +      G +P+H A+    +D +  LL+  A+++   
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
            +D + PLH A    H + A++LL  GA PN +
Sbjct: 336  LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
           + K  K++V ++ L      N  G+N    ++ A  H++ D+V   + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
           +T LH A+       A  LL+ G   N + +  +TPLH A   GH ++  LLL   A+  
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
             N  G   L            E ++P      KH   + +  R    PL +   Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++ +G + L++A +  +L +VK L+E+GA+ N+    G+TPL  A  +G  +++  L
Sbjct: 104  VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  G K        +  LH A  N+  + A +LLQN  NP+
Sbjct: 164  INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 36/117 (30%), Positives = 58/117 (49%)

Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
            +G + LH+A + G + + + L+E  A  N     G TPLH A +  ++DI+  LL  G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
             +    +G  PLH A   N ++ A  LLQ G + N +  +  + L  A  E   E++
Sbjct: 595  PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/99 (33%), Positives = 54/99 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I  +   G S +H+A +  +L  V+ L++  A+++       TPLH A++ G   +   L
Sbjct: 298  IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            L  GAK N   ++G  PLH A   NH++  E+LL+ GA+
Sbjct: 358  LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 37/90 (41%), Positives = 45/90 (50%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           IK G  V+  +  G+T LH AS  G  +    LL+  ADVN K     +PLH A   GH 
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
            +  LLL NGA P   + DG   L  AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A R  +      L+++  + ++    G+TPLH A++  ++++   LL  GA VN   
Sbjct: 177  LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
             +GI PLH A    ++    +LL  GA    K + + + L  A      ++ E+L  +GA
Sbjct: 237  QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 30/84 (35%), Positives = 46/84 (54%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +++ ++    + +G +VN     G T LH AS  G       LL  GA +  K   +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           +TPLH A  NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G + ++ AA  D  D V   ++    ++  +    T LH A+  G +R A  LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
           N + L   TPLH A    H +V ELLL  GA      + G   L  A  +     +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 605 ER 606
           +R
Sbjct: 425 QR 426



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 34/107 (31%), Positives = 51/107 (47%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           IN  N  G N ++ A+      +V   + K   +   +  G TALH A++ G      EL
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
           +  GA+VN +     TPL+ A    H +V + LL NGA+     +DG
Sbjct: 98  VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 48/97 (49%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N R + G   ++ A   +   ++   +K G +++  + +G T LH AS  G       LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           + GA  N+  +   TPLH A   GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)

Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
           KK  ++V ++ L    SI+     G   ++ A+      +V + +++G + N  +    T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
            LH A+  G    A  LL+  A VN K     TPLH A   GH  + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)

Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           LH  A   HH      + KG   N  +  G+T LH A      R    LLK GA ++   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
              +TPLH A   GH  + + LL  GA P   N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 34/115 (29%), Positives = 52/115 (45%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  ++ G   ++ AA    A++V   + K  N N  + +G T LH  +  G    A  
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           L+K G  V+       TPLH A   G+ K+ + LL + AD   +   G   L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/90 (31%), Positives = 41/90 (45%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AAL    ++V   +  G NVN  S  G+T L+ A+          LL+ GA+ 
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
           N+      TPL  A+  GH  V   L+  G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)

Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
           G  +   +  G + +H A+ G        LL+  A+++   L  +TPLH A   GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
           ++LL  GA P  R  +G   L  A      R++E  + K    + +   S + PL +   
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413

Query: 632 YQH 634
             H
Sbjct: 414 MGH 416



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 29/93 (31%), Positives = 44/93 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AA     + V   ++K  +    +  G+T LH A+  G  R A  LL+  A  
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           N  G   +TPLH AV + +  + +LLL  G  P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 33/100 (33%), Positives = 42/100 (42%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA     ++V   ++   N N  + AG T LH A+  G   T   LL+  A         
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
            TPLH A   G  +VAELLL   A P     +G   L  A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 30/84 (35%), Positives = 38/84 (45%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +DD       ++   N +  S  G+T LH A+       A  LL  GA VN      
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           ITPLH A   G+  +  LLL  GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 38.5 bits (88), Expect = 0.062
 Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G   +Y AA  +  ++V   ++ G N N  +  G+T L  A   G     + 
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           L+  G     KG  ++  LH A  N   + A +LL N  +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199



 Score = 35.0 bits (79), Expect = 0.69
 Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  N+  E  ++ AA     ++  + ++    VN  +    T LH A+  G       
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+  A+ N+      TPLH A   GH +    LL   A        G   L  A     
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
            R+ E  + +      +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
           E + V ++ L+   S+N     G   ++ A+   +  +V   + +G  +   +    T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           H A+  G  R +  LL  GA +  K    ++P+H A    H     LLL   A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 24/86 (27%), Positives = 41/86 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ A+ + +  LV   ++   +VN  +  G++ LH+A+  G     + LLK GA  
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
           N       TPL  A   G+  V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 66/241 (27%), Positives = 112/241 (46%), Gaps = 18/241 (7%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N  N  G + LHL  + G++P+   LI+ G  V+     G+TPLH AS+ G+I ++  LL
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A VN +   G  PLH A    H     +LL+NGA+PN+      + L  A   K   
Sbjct: 722  QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA---KRLG 778

Query: 1269 LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSV 1328
             +     ++ V  + S  +V++K        H+  F    +T+D   L   E   E L  
Sbjct: 779  YISVTDVLKVVTDETSFVLVSDK--------HRMSF---PETVD-EILDVSEDEGEELIS 826

Query: 1329 HQTLSAILQDIEEKQEYLLEFEIRNPEDAEQYIEKMLKIKKIMDNVLAKQKAERDDLAKK 1388
             +      +D++E++E LL+F  +  +  E     + +I   M   +  +  E++  +K+
Sbjct: 827  FKAERRDSRDVDEEKE-LLDFVPKLDQVVES--PAIPRIPCAMPETVVIRSEEQEQASKE 883

Query: 1389 Y 1389
            Y
Sbjct: 884  Y 884



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 38/102 (37%), Positives = 59/102 (57%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++N +    ++ LH A R G+  +VK L+E+ A+ NL   AG TPLH A+ EG ++ ++ 
Sbjct: 462  KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            LL+  A   C    G  PLH A     ++ AE+LL+  A+PN
Sbjct: 522  LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 13/272 (4%)

Query: 1130 SQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGW 1189
            +++ + E++       G  N  + +G + LHLA + G+  +V  L+   A+ NL + +G 
Sbjct: 610  AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 1190 TPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQ 1249
            TPLH  + EG + +   L+K G  V+     G  PLH A    ++K  + LLQ+ A+ N 
Sbjct: 670  TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 1250 KDQKQKSALDEADDEKMKE----LLRSYGAIETVNRDESDAIVNEKIPAVRSKRHKQCFC 1305
            K +   S L +A  +   +    LL++  +   V+ D +  +      A+  +       
Sbjct: 730  KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL------AIAKRLGYISVT 783

Query: 1306 DDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIEEKQEYLLEF--EIRNPEDAEQYIEK 1363
            D  K +   +       +  +S  +T+  IL   E++ E L+ F  E R+  D ++  E 
Sbjct: 784  DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1364 MLKIKKIMDNVLAKQKAERDDLAKKYRVSIES 1395
            +  + K +D V+      R   A    V I S
Sbjct: 844  LDFVPK-LDQVVESPAIPRIPCAMPETVVIRS 874



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 39/115 (33%), Positives = 64/115 (55%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K  + N R   G + LH+A ++ ++ +++ L+++GA ++    +G TPLH AS  G + I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            +  LL+ GA  N  N+    PLH A    H + A+ LLQN A  N K +  ++ L
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 39/107 (36%), Positives = 58/107 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A    NL + + L+  GA VN     G TPLH AS  G++ ++  LL  GA++
Sbjct: 206  GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
              +  D + PLH A  N H++ +EILL +GA    K +   S +  A
Sbjct: 266  ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 38/94 (40%), Positives = 55/94 (58%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A   G+LP+VK L++ GA  N+++    TPLH A+  G  ++   LL+  AKV
Sbjct: 404  GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            N +  D   PLH A    H    ++LL+N ANPN
Sbjct: 464  NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 37/101 (36%), Positives = 55/101 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            IN  N  G + LHLA + G++ +V  L+     +      G T LH A+  G  +++ EL
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  GA VN ++  G  PL+ A   NHL+  + LL+NGAN N
Sbjct: 98   VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 34/100 (34%), Positives = 51/100 (51%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+AV   NL +VK L+  G   +     G+TPLH A+ +  +++   LL
Sbjct: 563  NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            + G   N E++ G+ PLH A    H +   +LL   AN N
Sbjct: 623  QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 40/124 (32%), Positives = 61/124 (49%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LH+A R G++  V AL+E  A        G+TPLH A+  G + +   LL
Sbjct: 497  NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A  N    +G+ PLH AV +N+L   ++LL  G +P+       + L  A  +   E
Sbjct: 557  ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616

Query: 1269 LLRS 1272
            + RS
Sbjct: 617  VARS 620



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A   G+  + K L++ GA  N     G+TPLH A  +  + ++  LLK GA ++   
Sbjct: 342  LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYG 1274
              G+ PLH A    HL   + LLQ GA+PN  + K ++ L  A      E  K LL++  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 1275 AIETVNRDE 1283
             +    +D+
Sbjct: 462  KVNAKAKDD 470



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 34/102 (33%), Positives = 53/102 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            +   +N     G + LH+A RRGN+ +V+ L++ GA +        TPLH A+  G + I
Sbjct: 228  RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
               LL  GA +  +  +G+ P+H A   +HL    +LLQ  A
Sbjct: 288  SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A ++  + + ++L++ G   N     G TPLH A+ EG  +++  LL   A  
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNG 1244
            N  N  G+ PLH      H+  A++L+++G
Sbjct: 662  NLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 29/92 (31%), Positives = 51/92 (55%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH A R G++ + + L++ GA +      G +P+H A+    +D +  LL+  A+++   
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
            +D + PLH A    H + A++LL  GA PN +
Sbjct: 336  LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 16/180 (8%)

Query: 466 SGKKEKMKVNKISLHSINRRNIFGEN---LVYKAALHDDADLVHHCIKKGGNVNQPSYAG 522
           + K  K++V ++ L      N  G+N    ++ A  H++ D+V   + +GG+ + P++ G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 523 WTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
           +T LH A+       A  LL+ G   N + +  +TPLH A   GH ++  LLL   A+  
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 583 FRNDDGKCALDEAKDLCMKRLLERYIP------KHQKCLTSAQRSSIDPLDIEDVYQHKK 636
             N  G   L            E ++P      KH   + +  R    PL +   Y + K
Sbjct: 663 LGNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 4/101 (3%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N ++ +G + L++A +  +L +VK L+E+GA+ N+    G+TPL  A  +G  +++  L
Sbjct: 104  VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
            +  G K        +  LH A  N+  + A +LLQN  NP+
Sbjct: 164  INYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 36/117 (30%), Positives = 58/117 (49%)

Query: 1154 RGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAK 1213
            +G + LH+A + G + + + L+E  A  N     G TPLH A +  ++DI+  LL  G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1214 VNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELL 1270
             +    +G  PLH A   N ++ A  LLQ G + N +  +  + L  A  E   E++
Sbjct: 595  PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/99 (33%), Positives = 54/99 (54%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I  +   G S +H+A +  +L  V+ L++  A+++       TPLH A++ G   +   L
Sbjct: 298  IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            L  GAK N   ++G  PLH A   NH++  E+LL+ GA+
Sbjct: 358  LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 37/90 (41%), Positives = 45/90 (50%)

Query: 509 IKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHY 568
           IK G  V+  +  G+T LH AS  G  +    LL+  ADVN K     +PLH A   GH 
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747

Query: 569 KVAELLLLNGADPLFRNDDGKCALDEAKDL 598
            +  LLL NGA P   + DG   L  AK L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A R  +      L+++  + ++    G+TPLH A++  ++++   LL  GA VN   
Sbjct: 177  LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
             +GI PLH A    ++    +LL  GA    K + + + L  A      ++ E+L  +GA
Sbjct: 237  QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 30/84 (35%), Positives = 46/84 (54%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +++ ++    + +G +VN     G T LH AS  G       LL  GA +  K   +
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           +TPLH A  NGH +++E+LL +GA
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGA 296



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 4/122 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G + ++ AA  D  D V   ++    ++  +    T LH A+  G +R A  LL  GA  
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL----CMKRLL 604
           N + L   TPLH A    H +V ELLL  GA      + G   L  A  +     +K LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 605 ER 606
           +R
Sbjct: 425 QR 426



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 34/107 (31%), Positives = 51/107 (47%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           IN  N  G N ++ A+      +V   + K   +   +  G TALH A++ G      EL
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
           +  GA+VN +     TPL+ A    H +V + LL NGA+     +DG
Sbjct: 98  VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 48/97 (49%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N R + G   ++ A   +   ++   +K G +++  + +G T LH AS  G       LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
           + GA  N+  +   TPLH A   GH +VA+ LL N A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 3/117 (2%)

Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
           KK  ++V ++ L    SI+     G   ++ A+      +V + +++G + N  +    T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
            LH A+  G    A  LL+  A VN K     TPLH A   GH  + +LLL N A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 32/93 (34%), Positives = 40/93 (43%), Gaps = 5/93 (5%)

Query: 498 LHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           LH  A   HH      + KG   N  +  G+T LH A      R    LLK GA ++   
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRN 585
              +TPLH A   GH  + + LL  GA P   N
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 34/115 (29%), Positives = 52/115 (45%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  ++ G   ++ AA    A++V   + K  N N  + +G T LH  +  G    A  
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           L+K G  V+       TPLH A   G+ K+ + LL + AD   +   G   L +A
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/90 (31%), Positives = 41/90 (45%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AAL    ++V   +  G NVN  S  G+T L+ A+          LL+ GA+ 
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNG 578
           N+      TPL  A+  GH  V   L+  G
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 1/123 (0%)

Query: 512 GGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVA 571
           G  +   +  G + +H A+ G        LL+  A+++   L  +TPLH A   GH++VA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 572 ELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDV 631
           ++LL  GA P  R  +G   L  A      R++E  + K    + +   S + PL +   
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASF 413

Query: 632 YQH 634
             H
Sbjct: 414 MGH 416



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 29/93 (31%), Positives = 44/93 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ AA     + V   ++K  +    +  G+T LH A+  G  R A  LL+  A  
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           N  G   +TPLH AV + +  + +LLL  G  P
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 33/100 (33%), Positives = 42/100 (42%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA     ++V   ++   N N  + AG T LH A+  G   T   LL+  A         
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
            TPLH A   G  +VAELLL   A P     +G   L  A
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 30/84 (35%), Positives = 38/84 (45%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA +DD       ++   N +  S  G+T LH A+       A  LL  GA VN      
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 556 ITPLHDAVMNGHYKVAELLLLNGA 579
           ITPLH A   G+  +  LLL  GA
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 38.5 bits (88), Expect = 0.062
 Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N ++  G   +Y AA  +  ++V   ++ G N N  +  G+T L  A   G     + 
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           L+  G     KG  ++  LH A  N   + A +LL N  +P
Sbjct: 163 LINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199



 Score = 35.0 bits (79), Expect = 0.69
 Identities = 35/148 (23%), Positives = 57/148 (38%), Gaps = 1/148 (0%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  N+  E  ++ AA     ++  + ++    VN  +    T LH A+  G       
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+  A+ N+      TPLH A   GH +    LL   A        G   L  A     
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDI 628
            R+ E  + +      +A ++ + PL +
Sbjct: 549 VRVAELLLERDAH-PNAAGKNGLTPLHV 575



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 470 EKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTAL 526
           E + V ++ L+   S+N     G   ++ A+   +  +V   + +G  +   +    T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 527 HEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
           H A+  G  R +  LL  GA +  K    ++P+H A    H     LLL   A+
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330



 Score = 34.7 bits (78), Expect = 0.90
 Identities = 24/86 (27%), Positives = 41/86 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ A+ + +  LV   ++   +VN  +  G++ LH+A+  G     + LLK GA  
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELL 574
           N       TPL  A   G+  V ++L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 55/171 (32%), Positives = 94/171 (54%), Gaps = 6/171 (3%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            ++  ++ G + L +A  +GN+ +V+ L++ G D N  D+AGWTPLH A+ EG   I   L
Sbjct: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDE--- 1264
            ++ GA+ N  + DG +P   A    H    +ILL+N +N +Q+    ++AL  A  E   
Sbjct: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926

Query: 1265 KMKELLRSYGAIETVNRDESDAIVNEKIPAVRSK-RHKQCFCDDGKTIDSS 1314
             + ELL S+GA   VN  ++D      I A+ ++    + F ++G  +++S
Sbjct: 927  DIVELLFSHGA--DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 48/137 (35%), Positives = 71/137 (51%), Gaps = 5/137 (3%)

Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
            +A G + L LA R+G+  +V  LI  GA++N  D  GWT L  A+  G  +++  LL AG
Sbjct: 575  DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634

Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKE 1268
             KV+C + D    L  A    H      LLQ+GA  N+ D + ++AL  A      ++ E
Sbjct: 635  VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694

Query: 1269 LLRSYGAIETVNRDESD 1285
             L  +GA   VN ++ D
Sbjct: 695  HLLDHGA--EVNHEDVD 709



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 40/131 (30%), Positives = 71/131 (54%), Gaps = 3/131 (2%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +   +A G + LH++  +G++ +V+ LI   ADVN  DN   + L  A+ +G + ++  L
Sbjct: 972  VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDE 1264
            ++ GA V+     G   L  A    H+   ++LL++GA+PN  DQ  ++A+  A      
Sbjct: 1032 IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091

Query: 1265 KMKELLRSYGA 1275
            ++ +LL  YGA
Sbjct: 1092 QIIKLLEKYGA 1102



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 58/185 (31%), Positives = 81/185 (43%), Gaps = 43/185 (23%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI----- 1203
            N R+  G + LH+A   G+  + +ALIE GA  N  DN G  P   AS EG  D      
Sbjct: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900

Query: 1204 ---------------------------IVELLKA-GAKVNCENIDGILPLHDAVANNHLK 1235
                                       IVELL + GA VNC++ DG   L+     N L 
Sbjct: 901  ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960

Query: 1236 AAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGAIETVNRDESDAIVNEKI 1292
             AE  L+NGAN    D + ++AL  +      +M ++L +Y A       + +A  NEK 
Sbjct: 961  MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA-------DVNAADNEKR 1013

Query: 1293 PAVRS 1297
             A++S
Sbjct: 1014 SALQS 1018



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 38/132 (28%), Positives = 66/132 (50%), Gaps = 3/132 (2%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I++R   G + L +A   G+  +V+ L   GADVN  D  G   L+  + E  + +    
Sbjct: 906  IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYF 965

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDE 1264
            L+ GA V   + +G   LH +    H++  ++L+   A+ N  D +++SAL  A      
Sbjct: 966  LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025

Query: 1265 KMKELLRSYGAI 1276
            K+ +LL  +GA+
Sbjct: 1026 KVVQLLIEHGAV 1037



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 3/167 (1%)

Query: 1109 HNIDSHSTDNMSKE-LANISKLSQREKKE--ISHKPGMKAGRINKRNARGESQLHLAVRR 1165
            H  + +  DN  +  L   + +  RE  E  + H   +    ++ R A   + L +   +
Sbjct: 666  HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASK 725

Query: 1166 GNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPL 1225
            G+  +V  LI+ GA+V+  D  G TPL  A+ EG +D++  LL+ GA V+  + +G  PL
Sbjct: 726  GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785

Query: 1226 HDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLRS 1272
              A +  H      LL  GA  +  D + ++ L  A  +   E++R+
Sbjct: 786  LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 40/120 (33%), Positives = 61/120 (50%), Gaps = 3/120 (2%)

Query: 1143 MKAG-RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSI 1201
            +KAG  +N  + R    +  A+ R +   ++ L+++GA VN  D+ G T L  A+  GS+
Sbjct: 501  VKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558

Query: 1202 DIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            D++  L+  GA +  E+  G  PL  A    H K    L+  GAN N  DQ   +AL  A
Sbjct: 559  DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 34/114 (29%), Positives = 55/114 (48%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N+ ++ G + L  A   G+L +V  L+  GAD+ + D  G TPL  A+ +G   ++  L
Sbjct: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            +  GA +N  + DG   L  A    H +    LL  G   +  D   ++AL  A
Sbjct: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 40/154 (25%), Positives = 66/154 (42%)

Query: 455 NGKQIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGN 514
           NG+ +  N  +SG  + + +       +   +  G   +  AA      +V+  I  G N
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603

Query: 515 VNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
           +N     GWTAL  A+ GG     S LL  G  V+       T L  A   GH  +   L
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663

Query: 575 LLNGADPLFRNDDGKCALDEAKDLCMKRLLERYI 608
           L +GA+    +++G+ AL  A  +  + ++E  +
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 33/97 (34%), Positives = 52/97 (53%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + L +A   G++ +V  L+E GADV+  DN G TPL  A++ G   ++  LL  GA V
Sbjct: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKD 1251
            +  + +G   L  A A  +++    LL  G + N +D
Sbjct: 808  DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            +++  +A   + L  A   G+  +V  L++ GA+VN  DN G T L  A+  G  +I+  
Sbjct: 636  KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695

Query: 1207 LLKAGAKVNCENIDGILPLHDA-----VANNHLKAAEILLQNGANPNQKDQ 1252
            LL  GA+VN E++DG   L  A      +  H     +L+  GA  +  D+
Sbjct: 696  LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 746



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 33/99 (33%), Positives = 52/99 (52%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N  +    S L  A  +G++ +V+ LIE GA V+   N G T L  A+ EG ID++  L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            L+ GA  N  +  G   +  A  N H +  ++L + GA+
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 29/98 (29%), Positives = 45/98 (45%)

Query: 482  INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
            +N ++  G   +Y  AL +   +  + ++ G NV      G TALH +   G       L
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 542  LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
            +   ADVN     + + L  A   GH KV +LL+ +GA
Sbjct: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 31/93 (33%), Positives = 43/93 (46%)

Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
           D +   +  G +VNQ    G T L  A+  G     + L+  GAD+ I+  +  TPL  A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585

Query: 563 VMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
              GH KV   L+  GA+    + DG  AL  A
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 30/115 (26%), Positives = 51/115 (44%)

Query: 481  SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
            +I++R   G N +  AAL    D+V      G +VN     G   L+  ++      A  
Sbjct: 905  NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964

Query: 541  LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
             L+ GA+V        T LH +   GH ++ ++L+   AD    +++ + AL  A
Sbjct: 965  FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 37/121 (30%), Positives = 50/121 (41%), Gaps = 4/121 (3%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   +  AA    A +V+  +  G  V+     G T L  AS  G       LL  G D 
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGK----CALDEAKDLCMKRLL 604
           N +     TPLH A   GH  + E L+  GA     ++DG+     A  E    C++ LL
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900

Query: 605 E 605
           E
Sbjct: 901 E 901



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 29/110 (26%), Positives = 48/110 (43%)

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
           N R+  G   ++ AA      +    I++G   N+    G      AS  G Y     LL
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
           +  ++++ +G      L  A + GH  + ELL  +GAD   ++ DG+  L
Sbjct: 901 ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 31/115 (26%), Positives = 50/115 (43%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S+N+ +  G  L+  AA     D+V+  + +G ++      G T L  A+  G  +  + 
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNC 596

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
           L+  GA++N       T L  A   GH +V   LL  G      + D + AL  A
Sbjct: 597 LIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 482 INRRNIFGENLVYKAAL-----HDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYR 536
           +N  ++ G   +  AAL        A +V   I +G  V+     G T L  A+  G   
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762

Query: 537 TASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
               LL+GGADV+       TPL  A   GH  V   LL  GA     + +G+  L  A
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 27/90 (30%), Positives = 40/90 (44%)

Query: 503 DLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDA 562
           D V   ++   N++Q  Y G  AL  A++ G       L   GADVN K       L+  
Sbjct: 894 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953

Query: 563 VMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
            +     +AE  L NGA+    + +G+ AL
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTAL 983



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 14/159 (8%)

Query: 437  PALMIDGKEKNMHSARF--KNGKQIRKNEQ----------FSGKKEKMKVNKISLHS-IN 483
            P L I   E  +  A +  +NG  +  ++           + G  E ++V  I+ H+ +N
Sbjct: 948  PTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV-LIAYHADVN 1006

Query: 484  RRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLK 543
              +    + +  AA      +V   I+ G  V+     G TAL  A+  G       LL+
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066

Query: 544  GGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPL 582
             GAD N    +  T +  A  NGH ++ +LL   GA  L
Sbjct: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105



 Score = 31.2 bits (69), Expect = 9.9
 Identities = 28/93 (30%), Positives = 39/93 (41%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA     D+V   ++ G +V+     G T L  A+  G     + LL  GA V+      
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
            T L  A   G+ +V   LL  G D   R+D G
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847


>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
          Length = 1711

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 42/100 (42%), Positives = 58/100 (58%)

Query: 1174 LIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNH 1233
            L +   DVN  DNAG+T LHEA + G  DI+  LL+ GA VNC   DG  P+HDAV N++
Sbjct: 1442 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDN 1501

Query: 1234 LKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLRSY 1273
            L+   +LL  GA+P       ++A+  A  + MK  L  +
Sbjct: 1502 LETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDH 1541



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 2/117 (1%)

Query: 494  YKAALHDDA-DLVHHCIKKGG-NVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIK 551
            + A + ++A D+V +C++K   +VN    AG+TALHEA   G+    + LL+ GA+VN  
Sbjct: 1426 HMATVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCS 1485

Query: 552  GLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLERYI 608
                  P+HDAV+N + +   LLL  GADP      G+ A+  A    MKR L  ++
Sbjct: 1486 AQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHL 1542



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 3/87 (3%)

Query: 1196 SNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQK 1255
            S E    ++  L K    VN  +  G   LH+A +        ILL++GAN N   Q   
Sbjct: 1431 SEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGT 1490

Query: 1256 SALDEA---DDEKMKELLRSYGAIETV 1279
              + +A   D+ +   LL SYGA  T+
Sbjct: 1491 RPVHDAVVNDNLETIWLLLSYGADPTL 1517


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 5/182 (2%)

Query: 1103 LESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLA 1162
            L  E  H ++ + TD +  E A ++  + R K E+          +++ N RG   L  A
Sbjct: 1053 LGMEKEHEVEVNGTDTLWGETA-LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1111

Query: 1163 VRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGI 1222
             R+G+  +V+ L+E G DVNL+D  G TPL  A+ EG +  +  LL  GA ++  + +G+
Sbjct: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171

Query: 1223 LPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGAIET 1278
              L  A    H    + L++ GA  +Q D+  ++ LD A    D E +  L+     IE 
Sbjct: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231

Query: 1279 VN 1280
            V+
Sbjct: 1232 VD 1233



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 29/102 (28%), Positives = 51/102 (50%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K   ++  +  G S L  A  +G+  +V+ L+E GA ++  D  G TPL  A+  G  + 
Sbjct: 1159 KGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1218

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
            ++ L++ GA +   +  G+ PL  A+   +      LL+ GA
Sbjct: 1219 VLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 39/148 (26%), Positives = 64/148 (43%), Gaps = 5/148 (3%)

Query: 487  IFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGA 546
            ++GE  +  AA     ++    +  G  V++ +  G   L  A+  G ++    LL+ G 
Sbjct: 1069 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1128

Query: 547  DVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMK--RLL 604
            DVN+      TPL  A   GH    E LL  GA     + +G  AL  A   C+K  R +
Sbjct: 1129 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA---CLKGHRAV 1185

Query: 605  ERYIPKHQKCLTSAQRSSIDPLDIEDVY 632
             +Y+ +    +    ++   PLD+   Y
Sbjct: 1186 VQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 22/67 (32%), Positives = 36/67 (53%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I++ +  G + L LA   G+   V  L+E GA +   D++G  PL  A    +  ++V L
Sbjct: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255

Query: 1208 LKAGAKV 1214
            L+ GAK+
Sbjct: 1256 LRKGAKL 1262



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 2/94 (2%)

Query: 1167 NLPLVKALIESGADVNLNDNA--GWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILP 1224
            N+ + + LI  GA+VN           L   S+ G  +++  LL+ GA ++  + +G+  
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963

Query: 1225 LHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            L  A A  H+K   +L + G   +  D+K + AL
Sbjct: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 5/182 (2%)

Query: 1103 LESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLA 1162
            L  E  H ++ + TD +  E A ++  + R K E+          +++ N RG   L  A
Sbjct: 1061 LGMEKEHEVEVNGTDTLWGETA-LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1119

Query: 1163 VRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGI 1222
             R+G+  +V+ L+E G DVNL+D  G TPL  A+ EG +  +  LL  GA ++  + +G+
Sbjct: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179

Query: 1223 LPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGAIET 1278
              L  A    H    + L++ GA  +Q D+  ++ LD A    D E +  L+     IE 
Sbjct: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239

Query: 1279 VN 1280
            V+
Sbjct: 1240 VD 1241



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 29/102 (28%), Positives = 51/102 (50%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K   ++  +  G S L  A  +G+  +V+ L+E GA ++  D  G TPL  A+  G  + 
Sbjct: 1167 KGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1226

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGA 1245
            ++ L++ GA +   +  G+ PL  A+   +      LL+ GA
Sbjct: 1227 VLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 39/148 (26%), Positives = 64/148 (43%), Gaps = 5/148 (3%)

Query: 487  IFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGA 546
            ++GE  +  AA     ++    +  G  V++ +  G   L  A+  G ++    LL+ G 
Sbjct: 1077 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1136

Query: 547  DVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMK--RLL 604
            DVN+      TPL  A   GH    E LL  GA     + +G  AL  A   C+K  R +
Sbjct: 1137 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA---CLKGHRAV 1193

Query: 605  ERYIPKHQKCLTSAQRSSIDPLDIEDVY 632
             +Y+ +    +    ++   PLD+   Y
Sbjct: 1194 VQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 22/67 (32%), Positives = 36/67 (53%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            I++ +  G + L LA   G+   V  L+E GA +   D++G  PL  A    +  ++V L
Sbjct: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263

Query: 1208 LKAGAKV 1214
            L+ GAK+
Sbjct: 1264 LRKGAKL 1270



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 2/94 (2%)

Query: 1167 NLPLVKALIESGADVNLNDNA--GWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILP 1224
            N+ + + LI  GA+VN           L   S+ G  +++  LL+ GA ++  + +G+  
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971

Query: 1225 LHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            L  A A  H+K   +L + G   +  D+K + AL
Sbjct: 972  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 40/111 (36%), Positives = 59/111 (53%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            +N  N  G + LHLA +   + + + L+  GA V+     G+TPLH   + G+I I+  L
Sbjct: 690  VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            L+  AKVN +  +G  PLH A    H     +LLQN A+PN+      +AL
Sbjct: 750  LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 49/177 (27%), Positives = 88/177 (49%), Gaps = 4/177 (2%)

Query: 1102 HLESETIHNIDSHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHL 1161
            ++ S+ +H+  S +T N+  E A +   ++  + E+         ++  +    ++ LH+
Sbjct: 447  NIVSQLMHHGASPNTTNVRGETA-LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505

Query: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDG 1221
            + R G   +V+ L++ GA  N    +G+TPLH ++ EG  D+   LL  GA ++     G
Sbjct: 506  SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565

Query: 1222 ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELLRSYGA 1275
              PLH A     L+ A +LLQ  A+P+   +   + L  A   D++K+  LL   GA
Sbjct: 566  FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 44/132 (33%), Positives = 62/132 (46%), Gaps = 9/132 (6%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N  N RGE+ LH+A R G   +V+ L++ GA V        TPLH ++  G  DI+ +LL
Sbjct: 460  NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            + GA  N     G  PLH +    H   A  LL +GA+ +   +K  + L  A       
Sbjct: 520  QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA------- 572

Query: 1269 LLRSYGAIETVN 1280
                YG +E  N
Sbjct: 573  --AKYGKLEVAN 582



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 10/167 (5%)

Query: 1085 AHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKL-----SQREKKEISH 1139
            A SQ+ +   +E   +   E +  H     S D   K  AN S L        EK     
Sbjct: 4    AASQLKKNRDLEINAEEEPEKKRKHR--KRSRDRKKKSDANASYLRAARAGHLEKALDYI 61

Query: 1140 KPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEG 1199
            K G+    IN  N  G + LHLA + G++ +V  L++  A+V+     G T LH AS  G
Sbjct: 62   KNGVD---INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118

Query: 1200 SIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
              +++  L+  GA VN ++ +G  PL+ A   NHL+  + LL NGA+
Sbjct: 119  QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 36/113 (31%), Positives = 61/113 (53%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N    +G + +HLA + G++ +V  L+   A+VNL++ +G TPLH A+ E  +++   L+
Sbjct: 658  NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
              GA V+ +   G  PLH      ++K    LLQ+ A  N K +   + L +A
Sbjct: 718  NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 8/223 (3%)

Query: 1052 HIVEKMAKNCDTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNI 1111
            H   ++ KN D E N  +  +K     +             + +   R  HLE    +  
Sbjct: 3    HAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIK 62

Query: 1112 DSHSTDNMSKELANISKLSQREKK-EISHKPGMKAGRINKRNARGESQLHLAVRRGNLPL 1170
            +    +  ++   N   L+ +E   E+  +   +   ++    +G + LH+A   G   +
Sbjct: 63   NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEV 122

Query: 1171 VKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVA 1230
            VK L+ +GA+VN     G+TPL+ A+ E  ++++  LL  GA  +    DG  PL  A+ 
Sbjct: 123  VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ 182

Query: 1231 NNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKELL 1270
              H +   +LL+N    + K + +  AL  A   DD K   LL
Sbjct: 183  QGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALL 221



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 32/92 (34%), Positives = 50/92 (54%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + LH+A ++  + +   L+E GAD N     G   +H A+ EG +D++  LL   A V
Sbjct: 631  GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
            N  N  G+ PLH A   + +  AE+L+  GA+
Sbjct: 691  NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 3/159 (1%)

Query: 1113 SHSTDNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVK 1172
            +H+   + K         +  +K+  H+   K  R  K+ +   +    A R G+L    
Sbjct: 2    AHAASQLKKNRDLEINAEEEPEKKRKHR---KRSRDRKKKSDANASYLRAARAGHLEKAL 58

Query: 1173 ALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANN 1232
              I++G D+N+ +  G   LH AS EG ++++ ELL+  A V+     G   LH A    
Sbjct: 59   DYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAG 118

Query: 1233 HLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
              +  ++L+ NGAN N + Q   + L  A  E   E+++
Sbjct: 119  QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 10/150 (6%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N     G + LHL+ R G+  +   L++ GA +++    G+TPLH A+  G +++   LL
Sbjct: 526  NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKE 1268
            +  A  +     G+ PLH A   ++ K A +LL  GA+P+   +   + L  A  +   +
Sbjct: 586  QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645

Query: 1269 L---LRSYGAIETVNRDESDAIVNEKIPAV 1295
            +   L  YGA       +++A+  + I +V
Sbjct: 646  IATTLLEYGA-------DANAVTRQGIASV 668



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 35/113 (30%), Positives = 58/113 (51%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A   G+  + K L++  A+ N     G+TPLH A  +  I ++  LLK GA +    
Sbjct: 371  LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
              G+ P+H A    H+     L+ +GA+PN  + + ++AL  A      E++R
Sbjct: 431  ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVR 483



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 30/85 (35%), Positives = 48/85 (56%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A +RGN  +VK L++ GA ++     G TPLH  +  G   ++  LL   A +  + 
Sbjct: 272  LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331

Query: 1219 IDGILPLHDAVANNHLKAAEILLQN 1243
             +G+ PLH A   +HL   ++LLQ+
Sbjct: 332  KNGLSPLHMATQGDHLNCVQLLLQH 356



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 5/118 (4%)

Query: 1149 NKRNARGESQ-----LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            N  NA  ES+     LH+A   GN+ +   L+   A V+       TPLH AS  G+ ++
Sbjct: 224  NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANM 283

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
            +  LL  GAK++ +  DG+ PLH    + H +  E+LL   A    K +   S L  A
Sbjct: 284  VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 31/115 (26%), Positives = 59/115 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            K    N +   G + LH+A ++  + +++ L++ GA +     +G TP+H A+  G ++I
Sbjct: 389  KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSAL 1258
            + +L+  GA  N  N+ G   LH A  +   +    L+Q+GA    K +  ++ L
Sbjct: 449  VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 41/128 (32%), Positives = 61/128 (47%), Gaps = 4/128 (3%)

Query: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
           IN  N  G N ++ A+     ++V   +++  NV+  +  G TALH AS+ G       L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 542 LKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG----KCALDEAKD 597
           +  GA+VN +     TPL+ A    H +V + LL NGA      +DG      AL +  D
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD 186

Query: 598 LCMKRLLE 605
             +  LLE
Sbjct: 187 QVVSLLLE 194



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 41/145 (28%), Positives = 66/145 (45%), Gaps = 3/145 (2%)

Query: 1134 KKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLH 1193
            K E+++    K+   +     G + LH+A    N  +   L++ GA  +     G+TPLH
Sbjct: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636

Query: 1194 EASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQK 1253
             A+ +  +DI   LL+ GA  N     GI  +H A    H+    +LL   AN N  ++ 
Sbjct: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696

Query: 1254 QKSALDEADDE---KMKELLRSYGA 1275
              + L  A  E    + E+L + GA
Sbjct: 697  GLTPLHLAAQEDRVNVAEVLVNQGA 721



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 36/118 (30%), Positives = 55/118 (46%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           ++N  N  G   ++ AA  D  ++    + +G +V+  +  G+T LH     G  +  + 
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDL 598
           LL+  A VN K     TPLH A   GH  +  +LL N A P     +G  AL  A+ L
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 33/103 (32%), Positives = 53/103 (51%)

Query: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
            +A  I  +   G S LH+A +  +L  V+ L++    V+   N   T LH A++ G   +
Sbjct: 323  RAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382

Query: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGAN 1246
               LL   A  N + ++G  PLH A   N +K  E+LL++GA+
Sbjct: 383  AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 30/94 (31%), Positives = 49/94 (52%)

Query: 1155 GESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKV 1214
            G + +H+A   G++ +V  L+  GA  N  +  G T LH A+  G  +++  L++ GA+V
Sbjct: 433  GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492

Query: 1215 NCENIDGILPLHDAVANNHLKAAEILLQNGANPN 1248
              +  D   PLH +         + LLQ GA+PN
Sbjct: 493  EAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 59/247 (23%), Positives = 99/247 (40%), Gaps = 25/247 (10%)

Query: 1118 NMSKELANISKLS------QREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLV 1171
            N +  L+N S L+      Q ++  ++     +   ++ +   G + LH+    GN+ +V
Sbjct: 687  NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746

Query: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVAN 1231
              L++  A VN     G+TPLH+A+ +G   II  LL+  A  N   ++G   L  A   
Sbjct: 747  NFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806

Query: 1232 NHLKAAE---ILLQNGANPNQKDQKQK--------SALDEADDEKMKELLRSYGAIETVN 1280
             ++   +   I+ +         +K K          LD +DDE     +R   A E ++
Sbjct: 807  GYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDE-----VRKANAPEMLS 861

Query: 1281 RDESDAIVNEKIPAVRSKRHKQCFCDDGKTIDSSSLSHQERSRESLSVHQTLSAILQDIE 1340
              E  + V E   A+     K     D K +   SL  +     SL      SA L+   
Sbjct: 862  DGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGAR---SASLRSFS 918

Query: 1341 EKQEYLL 1347
              + Y L
Sbjct: 919  SDRSYTL 925



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 27/92 (29%), Positives = 49/92 (53%)

Query: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
            LH+A R+ +      L+++  + ++   +G+TPLH A++ G+I++   LL   A V+   
Sbjct: 206  LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265

Query: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQK 1250
             + I PLH A    +    ++LL  GA  + K
Sbjct: 266  RNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 42/156 (26%), Positives = 65/156 (41%), Gaps = 1/156 (0%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N  N+ GE  ++ AA    A++V + ++ G  V   +    T LH ++  G      +
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCM 600
           LL+ GA  N       TPLH +   GH  VA  LL +GA        G   L  A     
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577

Query: 601 KRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQHKK 636
             +    + K      +A +S + PL +   Y ++K
Sbjct: 578 LEVANLLLQK-SASPDAAGKSGLTPLHVAAHYDNQK 612



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 9/143 (6%)

Query: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
           AA  DD       ++   N +  S +G+T LH A+  G    A+ LL   A V+      
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268

Query: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG----KCALDEAKDLCMKRLLERYIPKH 611
           ITPLH A   G+  + +LLL  GA    +  DG     C      +  ++ LL+R  P  
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP-- 326

Query: 612 QKCLTSAQRSSIDPLDIEDVYQH 634
              + S  ++ + PL +     H
Sbjct: 327 ---ILSKTKNGLSPLHMATQGDH 346



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 40/134 (29%), Positives = 65/134 (48%), Gaps = 3/134 (2%)

Query: 458 QIRKNE--QFSGKKEKMKVNKISLHSINRRNIFGENLVY-KAALHDDADLVHHCIKKGGN 514
           Q++KN   + + ++E  K  K    S +R+     N  Y +AA     +     IK G +
Sbjct: 7   QLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVD 66

Query: 515 VNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELL 574
           +N  +  G  ALH AS  G     SELL+  A+V+       T LH A + G  +V ++L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 575 LLNGADPLFRNDDG 588
           + NGA+   ++ +G
Sbjct: 127 VTNGANVNAQSQNG 140



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 5/107 (4%)

Query: 494 YKAALHDDADLVHH-----CIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           Y  ALH  A   H+      + K  N N  +  G+T LH A      +    LLK GA +
Sbjct: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI 426

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
                  +TP+H A   GH  +   L+ +GA P   N  G+ AL  A
Sbjct: 427 QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 35/117 (29%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 468 KKEKMKVNKISLH---SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWT 524
           KK ++KV ++ L    SI      G   ++ AA     ++V   +  G + N  +  G T
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

Query: 525 ALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           ALH A+  G       L++ GA V  K     TPLH +   G   + + LL  GA P
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 29/89 (32%), Positives = 42/89 (47%)

Query: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADV 548
           G   ++ A+L   A++V   +  G NVN  S  G+T L+ A+          LL  GA  
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166

Query: 549 NIKGLYQITPLHDAVMNGHYKVAELLLLN 577
           ++      TPL  A+  GH +V  LLL N
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEN 195



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 13/173 (7%)

Query: 429 AQNFRMQDPALMIDGKEKNMHSARFKNGKQIRKNEQFSGKKEKMKVNKISL------HSI 482
           A ++  Q  AL++  +  + H+A  KNG         + KK +M +    L      +++
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAA-KNGYTPL---HIAAKKNQMDIATTLLEYGADANAV 660

Query: 483 NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELL 542
            R+ I     V+ AA     D+V   + +  NVN  + +G T LH A+       A  L+
Sbjct: 661 TRQGIAS---VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717

Query: 543 KGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
             GA V+ +     TPLH     G+ K+   LL + A    +  +G   L +A
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 31/101 (30%), Positives = 47/101 (46%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           S N     G   ++ +A     D+    +  G +++  +  G+T LH A+  G    A+ 
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           LL+  A  +  G   +TPLH A    + KVA LLL  GA P
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 27/96 (28%), Positives = 44/96 (45%)

Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           ++ AA +D+  +    + +G + +  +  G+T LH A+       A+ LL+ GAD N   
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
              I  +H A   GH  +  LLL   A+    N  G
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 5/115 (4%)

Query: 522 GWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADP 581
           G + LH A+ G        LL+    V+      +T LH A   GHYKVA++LL   A+P
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393

Query: 582 LFRNDDGKCALDEAKDLCMKRLLE--RYIPKHQKCLTSAQRSSIDPLDIEDVYQH 634
             +  +G   L  A   C K  ++    + KH   + +   S + P+ +     H
Sbjct: 394 NAKALNGFTPLHIA---CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 445



 Score = 35.0 bits (79), Expect = 0.69
 Identities = 21/83 (25%), Positives = 38/83 (45%)

Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           ++ A+   +A++V   + +G  ++  +  G T LH  +  G  +    LL   A +  K 
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331

Query: 553 LYQITPLHDAVMNGHYKVAELLL 575
              ++PLH A    H    +LLL
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL 354



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 24/88 (27%), Positives = 39/88 (44%)

Query: 493 VYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKG 552
           ++ AA +   ++ +  ++K  + +    +G T LH A+     + A  LL  GA  +   
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628

Query: 553 LYQITPLHDAVMNGHYKVAELLLLNGAD 580
               TPLH A       +A  LL  GAD
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGAD 656


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
            sapiens]
          Length = 587

 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 49/140 (35%), Positives = 72/140 (51%), Gaps = 5/140 (3%)

Query: 1152 NARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAG 1211
            N   E+ L+ A  R N   VK L++  AD N   N GWT LHE+ +   ++++  L+  G
Sbjct: 154  NKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGG 213

Query: 1212 AKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA---DDEKMKE 1268
            AKV  +N  GI PL  A  +  L+A   L + GA+ N +     SAL EA   + E++ E
Sbjct: 214  AKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVE 273

Query: 1269 LLRSYGAIETVNRDESDAIV 1288
             L S GA    N+   D ++
Sbjct: 274  FLLSQGA--DANKTNKDGLL 291



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 35/104 (33%), Positives = 56/104 (53%)

Query: 1149 NKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELL 1208
            N R  RG + LH +V R +L +++ L+  GA V   +  G TPL  A+  G ++ +  L 
Sbjct: 184  NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243

Query: 1209 KAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQ 1252
            K GA +N +  D    L++A  N H +  E LL  GA+ N+ ++
Sbjct: 244  KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNK 287



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 42/146 (28%), Positives = 77/146 (52%), Gaps = 4/146 (2%)

Query: 1146 GRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
            G I++R  + E+ ++LA  RG+L  + +L+++GA+ ++++ +  TPL++A    + + + 
Sbjct: 115  GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174

Query: 1206 ELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEK 1265
             L++  A  N     G   LH++V+ N L+  +IL+  GA    K+    + L  A    
Sbjct: 175  ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSG 234

Query: 1266 MKELLR---SYGA-IETVNRDESDAI 1287
              E LR    YGA I T   D + A+
Sbjct: 235  QLEALRFLAKYGADINTQASDNASAL 260



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 48/178 (26%), Positives = 67/178 (37%), Gaps = 35/178 (19%)

Query: 490 ENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVN 549
           E  +YKA    +A+ V   ++   + N     GWTALHE+           L+ GGA V 
Sbjct: 158 ETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVE 217

Query: 550 IKGLYQITPL---------------------------------HDAVMNGHYKVAELLLL 576
            K  Y ITPL                                 ++A  N H +V E LL 
Sbjct: 218 SKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLS 277

Query: 577 NGADPLFRNDDGKCALDEAKDLCMKRLLERYIPKHQKCLTSAQRSSIDPLDIEDVYQH 634
            GAD    N DG   L  A      R+++  +P   +  T  +RS + PL +     H
Sbjct: 278 QGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSR--TRIRRSGVSPLHLAAERNH 333



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 30/95 (31%), Positives = 51/95 (53%)

Query: 1147 RINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVE 1206
            ++  +NA G + L +A + G L  ++ L + GAD+N   +   + L+EA      +++  
Sbjct: 215  KVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEF 274

Query: 1207 LLKAGAKVNCENIDGILPLHDAVANNHLKAAEILL 1241
            LL  GA  N  N DG+LPLH A    + +  ++LL
Sbjct: 275  LLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL 309



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 52/188 (27%), Positives = 84/188 (44%), Gaps = 22/188 (11%)

Query: 1071 DQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSKELANISKLS 1130
            + K  Y   PL + A S  +E  +   +           +I++ ++DN S  L    K  
Sbjct: 217  ESKNAYGITPLFVAAQSGQLEALRFLAKYGA--------DINTQASDNASA-LYEACKNE 267

Query: 1131 QREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWT 1190
              E  E     G  A   NK N  G   LH+A ++GN  +V+ L+   +   +   +G +
Sbjct: 268  HEEVVEFLLSQGADA---NKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVS 323

Query: 1191 PLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHD---------AVANNHLKAAEILL 1241
            PLH A+     +++  LL A   VN         L++         AV NN++ A E+LL
Sbjct: 324  PLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLL 383

Query: 1242 QNGANPNQ 1249
            Q+GA+PN+
Sbjct: 384  QHGADPNR 391



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 53/185 (28%), Positives = 83/185 (44%), Gaps = 21/185 (11%)

Query: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
            IN + +   S L+ A +  +  +V+ L+  GAD N  +  G  PLH AS +G+  I+  L
Sbjct: 249  INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308

Query: 1208 LKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANPNQK---------DQKQKSAL 1258
            L   ++       G+ PLH A   NH +  E LL    + N           + ++ SAL
Sbjct: 309  LPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSAL 367

Query: 1259 DEA---DDEKMKELLRSYGAIETVNRDESDAIVNEKIPAVR--SKRHKQCFCDDGKTIDS 1313
              A   ++    ELL  +GA    NRD    +++  + A+R    R  Q   D G  ID+
Sbjct: 368  YFAVVNNNVYATELLLQHGA--DPNRD----VISPLLVAIRHGCLRTMQLLLDHGANIDA 421

Query: 1314 SSLSH 1318
               +H
Sbjct: 422  YIATH 426



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 38/157 (24%)

Query: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASN------------------------ 1197
            A++ G+   +K +I+ G ++   +  GW PLHEA+                         
Sbjct: 64   AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123

Query: 1198 ----------EGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNGANP 1247
                       G +D ++ LL+AGA+ +  N     PL+ A    + +A +IL+Q+ A+ 
Sbjct: 124  EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183

Query: 1248 NQKDQKQKSALDEA---DDEKMKELLRSYGA-IETVN 1280
            N +  +  +AL E+   +D ++ ++L S GA +E+ N
Sbjct: 184  NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKN 220



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 1/102 (0%)

Query: 495 KAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKG-GADVNIKGL 553
           KA    D + +   IK+G N+ +P+  GW  LHEA+  G       L +     ++ + L
Sbjct: 63  KAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTL 122

Query: 554 YQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEA 595
            + T ++ A   GH      LL  GA+P   N   +  L +A
Sbjct: 123 QEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKA 164



 Score = 31.2 bits (69), Expect = 9.9
 Identities = 25/108 (23%), Positives = 47/108 (43%)

Query: 481 SINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASE 540
           +I++R +  E  VY A      D +   ++ G   +  + +  T L++A           
Sbjct: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175

Query: 541 LLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLFRNDDG 588
           L++  AD N +     T LH++V     +V ++L+  GA    +N  G
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYG 223


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,981,522
Number of Sequences: 37866
Number of extensions: 3280781
Number of successful extensions: 13005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 8459
Number of HSP's gapped (non-prelim): 3519
length of query: 1873
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1756
effective length of database: 13,817,196
effective search space: 24262996176
effective search space used: 24262996176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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