Search of human proteins with 116256445

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
         (2462 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...  4987   0.0  
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...  4948   0.0  
gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]           1472   0.0  
gi|209977080 REST corepressor 3 isoform a [Homo sapiens]              115   7e-25
gi|8922733 REST corepressor 3 isoform d [Homo sapiens]                115   7e-25
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  112   4e-24
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   112   4e-24
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  106   3e-22
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  106   3e-22
gi|7661892 REST corepressor 1 [Homo sapiens]                          105   5e-22
gi|27734799 REST corepressor 2 [Homo sapiens]                         103   3e-21
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    101   1e-20
gi|209977084 REST corepressor 3 isoform c [Homo sapiens]              100   1e-20
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         100   1e-20
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         100   1e-20
gi|163965366 nascent polypeptide-associated complex alpha subuni...    96   3e-19
gi|210032580 SET domain containing 1B [Homo sapiens]                   92   6e-18
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          89   5e-17
gi|150170670 piccolo isoform 2 [Homo sapiens]                          89   7e-17
gi|150378539 piccolo isoform 1 [Homo sapiens]                          89   7e-17
gi|110349719 titin isoform N2-A [Homo sapiens]                         88   1e-16
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    88   1e-16
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    87   2e-16
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     87   3e-16
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             85   8e-16
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    84   2e-15
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           83   3e-15
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    83   3e-15
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    83   4e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    81   1e-14

>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
          Length = 2462

 Score = 4987 bits (12937), Expect = 0.0
 Identities = 2462/2462 (100%), Positives = 2462/2462 (100%)

Query: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60
            MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
Sbjct: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60

Query: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120
            PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
Sbjct: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120

Query: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180
            SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
Sbjct: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180

Query: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
Sbjct: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240

Query: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300
            AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
Sbjct: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300

Query: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360
            RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
Sbjct: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360

Query: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420
            LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
Sbjct: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420

Query: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480
            KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
Sbjct: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480

Query: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540
            SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
Sbjct: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540

Query: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600
            DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
Sbjct: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600

Query: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660
            SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
Sbjct: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660

Query: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720
            NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
Sbjct: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720

Query: 721  AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 780
            AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT
Sbjct: 721  AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT 780

Query: 781  PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840
            PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK
Sbjct: 781  PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840

Query: 841  AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900
            AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS
Sbjct: 841  AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900

Query: 901  SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960
            SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ
Sbjct: 901  SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960

Query: 961  VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP 1020
            VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP
Sbjct: 961  VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKP 1020

Query: 1021 VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080
            VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH
Sbjct: 1021 VFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080

Query: 1081 DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT 1140
            DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT
Sbjct: 1081 DTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVT 1140

Query: 1141 MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT 1200
            MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT
Sbjct: 1141 MGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSIT 1200

Query: 1201 KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI 1260
            KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI
Sbjct: 1201 KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVI 1260

Query: 1261 YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG 1320
            YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG
Sbjct: 1261 YEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEG 1320

Query: 1321 LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP 1380
            LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP
Sbjct: 1321 LMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPP 1380

Query: 1381 SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG 1440
            SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG
Sbjct: 1381 SRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEG 1440

Query: 1441 SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK 1500
            SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK
Sbjct: 1441 SITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLK 1500

Query: 1501 SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL 1560
            SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL
Sbjct: 1501 SRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRL 1560

Query: 1561 QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP 1620
            QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP
Sbjct: 1561 QEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIP 1620

Query: 1621 LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY 1680
            LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY
Sbjct: 1621 LAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDY 1680

Query: 1681 ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG 1740
            ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG
Sbjct: 1681 ITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPG 1740

Query: 1741 TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE 1800
            TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE
Sbjct: 1741 TPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDRE 1800

Query: 1801 REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD 1860
            REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD
Sbjct: 1801 REKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQD 1860

Query: 1861 ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY 1920
            ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY
Sbjct: 1861 ALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVY 1920

Query: 1921 PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS 1980
            PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS
Sbjct: 1921 PTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVS 1980

Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS 2040
            GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS
Sbjct: 1981 GHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYS 2040

Query: 2041 PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL 2100
            PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL
Sbjct: 2041 PEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPL 2100

Query: 2101 PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA 2160
            PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA
Sbjct: 2101 PESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGA 2160

Query: 2161 SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE 2220
            SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE
Sbjct: 2161 SCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPE 2220

Query: 2221 GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE 2280
            GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE
Sbjct: 2221 GMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQE 2280

Query: 2281 INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA 2340
            INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA
Sbjct: 2281 INKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKA 2340

Query: 2341 LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS 2400
            LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS
Sbjct: 2341 LMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPS 2400

Query: 2401 SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD 2460
            SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD
Sbjct: 2401 SAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSD 2460

Query: 2461 SE 2462
            SE
Sbjct: 2461 SE 2462


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
          Length = 2524

 Score = 4948 bits (12835), Expect = 0.0
 Identities = 2461/2525 (97%), Positives = 2461/2525 (97%), Gaps = 64/2525 (2%)

Query: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60
            MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
Sbjct: 1    MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ 60

Query: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120
            PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
Sbjct: 61   PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP 120

Query: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180
            SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
Sbjct: 121  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD 180

Query: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
Sbjct: 181  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240

Query: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300
            AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
Sbjct: 241  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ 300

Query: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360
            RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
Sbjct: 301  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG 360

Query: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420
            LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
Sbjct: 361  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM 420

Query: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480
            KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
Sbjct: 421  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK 480

Query: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540
            SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
Sbjct: 481  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN 540

Query: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600
            DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
Sbjct: 541  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ 600

Query: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660
            SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
Sbjct: 601  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ 660

Query: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720
            NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
Sbjct: 661  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE 720

Query: 721  AEA-----------------TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 763
            AEA                 TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP
Sbjct: 721  AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP 780

Query: 764  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 823
            GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG
Sbjct: 781  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 840

Query: 824  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 883
            EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS
Sbjct: 841  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 900

Query: 884  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 943
            GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP
Sbjct: 901  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 960

Query: 944  LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1003
            LDLKQLKQRAAAIPPI VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR
Sbjct: 961  LDLKQLKQRAAAIPPI-VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1019

Query: 1004 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1063
            GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP
Sbjct: 1020 GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDP 1079

Query: 1064 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1123
            SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ
Sbjct: 1080 SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1139

Query: 1124 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1183
            LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA
Sbjct: 1140 LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEA 1199

Query: 1184 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1243
            SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP
Sbjct: 1200 SVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1259

Query: 1244 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1303
            SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD
Sbjct: 1260 SRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYD 1319

Query: 1304 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1363
            MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR
Sbjct: 1320 MMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR 1379

Query: 1364 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1423
            REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE
Sbjct: 1380 REAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREE 1439

Query: 1424 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1483
            LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV
Sbjct: 1440 LRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDV 1499

Query: 1484 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1543
            MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG
Sbjct: 1500 MADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAG 1559

Query: 1544 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1603
            HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE
Sbjct: 1560 HLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYE 1619

Query: 1604 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1663
            HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG
Sbjct: 1620 HLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRG 1679

Query: 1664 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1723
            YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII
Sbjct: 1680 YPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGII 1739

Query: 1724 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1783
            DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS
Sbjct: 1740 DLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTS 1799

Query: 1784 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1843
            SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA
Sbjct: 1800 SSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1859

Query: 1844 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1903
            SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT
Sbjct: 1860 SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT 1919

Query: 1904 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1963
            FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA
Sbjct: 1920 FPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPA 1979

Query: 1964 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2023
            SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS
Sbjct: 1980 SSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS 2039

Query: 2024 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2083
            IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG
Sbjct: 2040 IQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG 2099

Query: 2084 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2143
            PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP
Sbjct: 2100 PVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHP 2159

Query: 2144 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2203
            QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT
Sbjct: 2160 QQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKT 2219

Query: 2204 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2263
            SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF
Sbjct: 2220 SVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFF 2279

Query: 2264 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2323
            SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV
Sbjct: 2280 SKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAV 2339

Query: 2324 QEHASTNMGLEAIIRKALM----------------------------------------- 2342
            QEHASTNMGLEAIIRKALM                                         
Sbjct: 2340 QEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDH 2399

Query: 2343 -----GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2397
                 GGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED
Sbjct: 2400 TLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWED 2459

Query: 2398 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2457
            RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET
Sbjct: 2460 RPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYET 2519

Query: 2458 LSDSE 2462
            LSDSE
Sbjct: 2520 LSDSE 2524


>gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]
          Length = 2440

 Score = 1472 bits (3812), Expect = 0.0
 Identities = 1080/2648 (40%), Positives = 1422/2648 (53%), Gaps = 395/2648 (14%)

Query: 1    MSGSTQPVAQTWRATEP-RYPPHSLSYPVQIARTHTDVGLLEYQ--HHSRDYASHLSPGS 57
            MS S  P  Q   +TE  RYPPHS+ Y     R   +  + +Y+  H     AS L    
Sbjct: 1    MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQ 60

Query: 58   IIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPD-- 115
              Q  RRRPSLLSEF PG++R QE   R     + P     + + +ESKRPRLE + D  
Sbjct: 61   QQQQLRRRPSLLSEFHPGSDRPQER--RTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSH 118

Query: 116  ---------PLLRPSPLLATGQPAGSEDLTKDRSLTGKLE-PVSPPSPPHTDPELELVPP 165
                     PL+ P P    G  A S D  KD +  GK E P SP S      +    P 
Sbjct: 119  FQRVSAAVLPLVHPLP---EGLRA-SADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPS 174

Query: 166  RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225
            +LSKEELIQ+MDRVDREI  VEQQI KLKKKQQQLEEEAAKPPEPEKPVSPPP+E KHRS
Sbjct: 175  KLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRS 234

Query: 226  LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFK 285
            +VQIIYDENRKKAE AH+I EGLGP+VELPLYNQPSDT+ YHENIK NQ MRKKLIL+FK
Sbjct: 235  IVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFK 294

Query: 286  RRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRE 345
            RRNHARKQ EQK CQRYDQLMEAWEKKV+RIENNPRR+AKESK REYYEKQFPEIRKQRE
Sbjct: 295  RRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQRE 354

Query: 346  LQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQ 405
             QER Q RVGQRG+GLS + ARSEHE+SEIIDGLSEQEN EKQMRQL+VIPPM++DA+Q+
Sbjct: 355  QQERFQ-RVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQR 413

Query: 406  RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAE 465
            R+KFINMNGLM DPMKVYKDRQ MN+W++ EKE F++KF+QHPKNFGLIAS+LERK+V +
Sbjct: 414  RVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPD 473

Query: 466  CVLYYYLTKKNENYKSLVRRSY-RRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKE 524
            CVLYYYLTKKNENYK+LVRR+Y +RRG++QQ  +  Q+++ +++++   ++ + EK E+E
Sbjct: 474  CVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEE--DKAEKTEKKEEE 531

Query: 525  KEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITR 584
            K+ E EK+E++   EN KE   K+K D T+ E+ +E+E    +GRKTANSQGRRKGRITR
Sbjct: 532  KKDEEEKDEKEDSKENTKE---KDKIDGTA-EETEEREQATPRGRKTANSQGRRKGRITR 587

Query: 585  SMANEANSEEAITPQQS----------AELASMELNESSRWTEEEMETAKKGLLEHGRNW 634
            SM NEA +  A     +           E  S E  E+SRWTEEEME AKKGL+EHGRNW
Sbjct: 588  SMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNW 647

Query: 635  SAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEA 694
            +AIA+MVG+K+ +QCKNFYFNYK+R NLD +LQQHK K  ++    R   +  + AS  +
Sbjct: 648  AAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVS 707

Query: 695  AFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPK--- 751
            A     EDE++EAS    NEEE  E++E      S+     SP  E A   G   P    
Sbjct: 708  A----QEDEDIEAS----NEEENPEDSEVEAVKPSE----DSP--ENATSRGNTEPAVEL 753

Query: 752  PPATLGADGPPPG---PPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE 808
             P T  A    P    P T P ED    T+    +++  A T        +    V  +E
Sbjct: 754  EPTTETAPSTSPSLAVPSTKPAEDESVETQ---VNDSISAET--------AEQMDVDQQE 802

Query: 809  EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEA 868
               EE +   P        PPA +  +VD    E  V      + E    K +D + A  
Sbjct: 803  HSAEEGSVCDP--------PPATKADSVD---VEVRVPENHASKVEGDNTKERDLDRASE 851

Query: 869  TAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSP---RP 925
              E       ++    +   A+      D+DSSATCSADE  + +G  + + + P   +P
Sbjct: 852  KVE----PRDEDLVVAQQINAQRPEPQSDNDSSATCSADE--DVDGEPERQRMFPMDSKP 905

Query: 926  SLLTPTGDPRANASPQK--PLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPP 983
            SLL PTG     +SP K  PLDL QL+ RAA IPP+              P    P   P
Sbjct: 906  SLLNPTGSILV-SSPLKPNPLDLPQLQHRAAVIPPM----------VSCTPCN-IPIGTP 953

Query: 984  PPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSG 1043
                   +        S+   + R      D E                     PC TS 
Sbjct: 954  VSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRS---------------STSPCGTS- 997

Query: 1044 LPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103
               P    EV++ +PH       +  P G  LP     T RP  P PP I +    ++S 
Sbjct: 998  -KSPNREWEVLQPAPH----QVITNLPEGVRLP-----TTRPTRPPPPLIPSSKTTVASE 1047

Query: 1104 KHPSVLERQIGAISQG-----MSVQLHVPYSEHAKAP-VGPVTMGLPLPMDPKKLAPFSG 1157
            K   ++    G+ISQG     ++      Y++    P VG +++GLP   +  K A    
Sbjct: 1048 KPSFIMG---GSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPY 1104

Query: 1158 VKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYR 1217
            +KQE+ SPR Q   PE L V  AQ   V+RGTA G++  GSIT+G P++++  +S  + R
Sbjct: 1105 IKQEEFSPRSQNSQPEGLLV-RAQHEGVVRGTA-GAIQEGSITRGTPTSKISVESIPSLR 1162

Query: 1218 GSITHGTPA--------DVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVL 1269
            GSIT GTPA        + L KG+I+R+  EDS    ++GRE++  KGHVIYEGK GH+L
Sbjct: 1163 GSITQGTPALPQTGIPTEALVKGSISRMPIEDSSP--EKGREEAASKGHVIYEGKSGHIL 1220

Query: 1270 SYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAIS------SASIEGLMG 1323
            SY+   +       +G  S    HE +  KR+Y+ +EG + + +S      SA +EGL+ 
Sbjct: 1221 SYDNIKNA-----REGTRSPRTAHEISL-KRSYESVEGNIKQGMSMRESPVSAPLEGLIC 1274

Query: 1324 RAIPPERHSPH-HLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSR 1382
            RA+P  R SPH  LKE+  + GSI QG PR+  E+ ED L +  K +KRE      PP R
Sbjct: 1275 RALP--RGSPHSDLKERTVLSGSIMQGTPRATTESFEDGL-KYPKQIKRES-----PPIR 1326

Query: 1383 DLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREEL-----RHTPELPLAPRPL 1437
                A         K KP ++G + T+KE GRSIHEIPR+++     R TPE+  + RP+
Sbjct: 1327 AFEGAI-------TKGKP-YDG-ITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPI 1377

Query: 1438 KEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMAD-ARALERACYE 1496
             EGSI+QGTP+K+D   S   + KH+V+SLI  P +    + PL+++ +  + +ER  YE
Sbjct: 1378 IEGSISQGTPIKFDNN-SGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYE 1436

Query: 1497 -----ESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGA-----PFAGHLP 1546
                 E+++SR  +  SSG S+ R     + E  K + SP  Y+D  A      +   + 
Sbjct: 1437 DVKAGETVRSRHTSVVSSGPSVLRST---LHEAPKAQLSPGIYDDTSARRTPVSYQNTMS 1493

Query: 1547 RGSPVTTREPTPRLQEGSLSSSKA-SQDRKLTSTPRE----IAKSPHSTVPEHHPHPISP 1601
            RGSP+       R  + ++SS+K+ + +RK T TP +     AKSP   V     H  SP
Sbjct: 1494 RGSPMMN-----RTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSH--SP 1546

Query: 1602 YEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLD-AAAAYYLPRHLAPNPTYPHLYPPYL 1660
            ++   RG +  ++YRSH+P   DP ++P    LD AAAAY   R L+P P YP  Y  Y 
Sbjct: 1547 FDPHHRGSTAGEVYRSHLPTHLDP-AMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLY- 1604

Query: 1661 IRGYPDTAALEN-RQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGP 1719
                    A+EN RQTI+NDYITSQQM  N       R D+ RGLSPRE  L L Y A  
Sbjct: 1605 --------AMENTRQTILNDYITSQQMQVNL------RPDVARGLSPREQPLGLPYPA-T 1649

Query: 1720 RGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSR-HSSSPLSPGGPTHLTK 1778
            RGIIDL+ +P   +LVP   GT    MDR+ Y+P     F  R ++S+ +SPG PTHL  
Sbjct: 1650 RGIIDLTNMPP-TILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHL-- 1706

Query: 1779 PTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGS 1838
                +S+ERER+R+RE++R+RER   I  +++ +      RPG+EQ              
Sbjct: 1707 -AAAASAEREREREREKERERER---IAAASSDL----YLRPGSEQ-------------- 1744

Query: 1839 SSRPASHSHAHQHSPISPRTQDA-LQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP 1897
              RP SH +    SP S RTQ+  LQQRPSV   T    +IT ++P+    +       P
Sbjct: 1745 PGRPGSHGYVRSPSP-SVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGP 1803

Query: 1898 V----RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPR-------------VARPE 1940
                  PA+ +  A    L   +D         V   KE+                A  E
Sbjct: 1804 SISQGLPASRYNTAADA-LAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSE 1862

Query: 1941 RPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV-----------PPVSGHATIARTP 1989
            + + +     + K   +     ++ PS   +P   V           PP S +    RT 
Sbjct: 1863 QQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTR 1922

Query: 1990 AKN--LAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPV 2047
             K    A +          AS  D     +QS   S       SL  H      + +E +
Sbjct: 1923 GKTTITAANFIDVIITRQIASDKDARERGSQSSDSS------SSLSSHRYETPSDAIEVI 1976

Query: 2048 SPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSS 2107
            SP SSP+   +K      E +  +  E +   +  GP         L H RP    Q S 
Sbjct: 1977 SPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGP---------LHHYRP---QQESP 2024

Query: 2108 SPLLQTAPG--------VKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPG 2159
            SP  Q  P         V    R++TLA HI ++ITQD+ R+       P   P  +F  
Sbjct: 2025 SPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSS-QTPQQPPTSTFQN 2083

Query: 2160 ASCPVLD--LRRPPSDLYLPPPD-----HGAP-ARGSPH-----SEGGKRSPEPNKTSVL 2206
            +   ++   +R   S+ Y P        H  P +R SP      S G +    P ++ V 
Sbjct: 2084 SPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHV- 2142

Query: 2207 GGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKL 2266
                +  EP+SPP+      H +     LL + G +    R  ++SPG+ S  P+FF+KL
Sbjct: 2143 --SSEPYEPISPPQ--VPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKL 2198

Query: 2267 TESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEH 2326
             E+ S MVKSKKQEI +KLN+    + +   +QPGTEIFN+PA+T +G ++ R  +  + 
Sbjct: 2199 -ENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADP 2257

Query: 2327 ASTNMGLEAIIRKALMG------------------------------------------- 2343
            AS N+GLE IIRKALMG                                           
Sbjct: 2258 AS-NLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP 2316

Query: 2344 -GGG--KAKVSGRPSSRKAKSPAP--GLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDR 2398
              GG  K K+  + +SRK+KSP P  G    +RP SVSSVHSEGD +R+TP     WEDR
Sbjct: 2317 HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTP--GWAWEDR 2374

Query: 2399 PSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSG-PLAGPH---HAWDEEPKPLLCSQ 2454
            PSS GST FPYNPL MR+   + ++PP P   A S    A PH     W+ EP PLL +Q
Sbjct: 2375 PSSTGSTQFPYNPLTMRM---LSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQ 2431

Query: 2455 YETLSDSE 2462
            YETLSDS+
Sbjct: 2432 YETLSDSD 2439


>gi|209977080 REST corepressor 3 isoform a [Homo sapiens]
          Length = 553

 Score =  115 bits (287), Expect = 7e-25
 Identities = 109/413 (26%), Positives = 166/413 (40%), Gaps = 45/413 (10%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429

Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767
           SG S +EEE  +  +A         +  S  T  A     N P P         P     
Sbjct: 430 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 489

Query: 768 PPPEDIPAP-TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819
           PPP    A   +P P       P PP   P+ S PP + P+          PP
Sbjct: 490 PPPLQQQARFIQPRP---TLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 539



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 89/439 (20%), Positives = 152/439 (34%), Gaps = 108/439 (24%)

Query: 615  WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME 674
            WT E+    ++    HG+++  I +M+  KT++    +Y+++KK ++   ++ +   K+ 
Sbjct: 147  WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA 206

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
               N                                 G+ ++ VEE      N SD +  
Sbjct: 207  NRHN--------------------------------QGDSDDDVEETHPMDGNDSDYD-- 232

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADG------------------PPPGPPTPPPEDIPAP 776
              P  EA K+     P   + +G                     PP G      + +   
Sbjct: 233  --PKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVS 290

Query: 777  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG-EEQKPPAAEELA 835
              P  A+                       +  K+  +A    +E G EE KPP + +  
Sbjct: 291  CSPNAANTILRQLDMELISLKRQV------QNAKQVNSALKQKMEGGIEEFKPPESNQKI 344

Query: 836  VDTGKAEEPVKSECTEEAEEGPAK-GKDAEAA---------------------EATAEGA 873
                  EE +       A +G  K GKD +A                          E  
Sbjct: 345  NARWTTEEQLL------AVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEV 398

Query: 874  LKAEKKEGGSGRATTAKSSGAPQDSDSSATC----SADEVDEAEGGDKNRLLSPRP---- 925
            L+  + E G+ +A+   +S   +++ S++      S DE +EA+     R L P P    
Sbjct: 399  LQEWEAEQGT-QASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPS 457

Query: 926  SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPA-PPP 984
            S  TPT  P A  +   PL    L+    A P +   +   P ++ A   +P P    PP
Sbjct: 458  STPTPTA-PIATLNQPPPL----LRPTLPAAPALH--RQPPPLQQQARFIQPRPTLNQPP 510

Query: 985  PQNLQPESDAPQQPGSSPR 1003
            P  ++P +  P  P  +PR
Sbjct: 511  PPLIRPANSMP--PRLNPR 527



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%)

Query: 986  QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1045
            Q  Q  +      G   +  S  P+  +  E E+     A   +A +  G  P   S  P
Sbjct: 406  QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 460

Query: 1046 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103
             P  P   +   P    P+    AP  H  P  L   AR + PRP     PPPLI  A
Sbjct: 461  TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 517


>gi|8922733 REST corepressor 3 isoform d [Homo sapiens]
          Length = 495

 Score =  115 bits (287), Expect = 7e-25
 Identities = 109/413 (26%), Positives = 166/413 (40%), Gaps = 45/413 (10%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 89  WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 145

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 146 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 202

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 203 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 262

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 263 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 322

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 323 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 371

Query: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767
           SG S +EEE  +  +A         +  S  T  A     N P P         P     
Sbjct: 372 SGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQ 431

Query: 768 PPPEDIPAP-TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819
           PPP    A   +P P       P PP   P+ S PP + P+          PP
Sbjct: 432 PPPLQQQARFIQPRP---TLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPP 481



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 89/439 (20%), Positives = 152/439 (34%), Gaps = 108/439 (24%)

Query: 615  WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME 674
            WT E+    ++    HG+++  I +M+  KT++    +Y+++KK ++   ++ +   K+ 
Sbjct: 89   WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA 148

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
               N                                 G+ ++ VEE      N SD +  
Sbjct: 149  NRHN--------------------------------QGDSDDDVEETHPMDGNDSDYD-- 174

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADG------------------PPPGPPTPPPEDIPAP 776
              P  EA K+     P   + +G                     PP G      + +   
Sbjct: 175  --PKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVS 232

Query: 777  TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG-EEQKPPAAEELA 835
              P  A+                       +  K+  +A    +E G EE KPP + +  
Sbjct: 233  CSPNAANTILRQLDMELISLKRQV------QNAKQVNSALKQKMEGGIEEFKPPESNQKI 286

Query: 836  VDTGKAEEPVKSECTEEAEEGPAK-GKDAEAA---------------------EATAEGA 873
                  EE +       A +G  K GKD +A                          E  
Sbjct: 287  NARWTTEEQLL------AVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEV 340

Query: 874  LKAEKKEGGSGRATTAKSSGAPQDSDSSATC----SADEVDEAEGGDKNRLLSPRP---- 925
            L+  + E G+ +A+   +S   +++ S++      S DE +EA+     R L P P    
Sbjct: 341  LQEWEAEQGT-QASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPS 399

Query: 926  SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPA-PPP 984
            S  TPT  P A  +   PL    L+    A P +   +   P ++ A   +P P    PP
Sbjct: 400  STPTPTA-PIATLNQPPPL----LRPTLPAAPALH--RQPPPLQQQARFIQPRPTLNQPP 452

Query: 985  PQNLQPESDAPQQPGSSPR 1003
            P  ++P +  P  P  +PR
Sbjct: 453  PPLIRPANSMP--PRLNPR 469



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 6/118 (5%)

Query: 986  QNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLP 1045
            Q  Q  +      G   +  S  P+  +  E E+     A   +A +  G  P   S  P
Sbjct: 348  QGTQASNGDASTLGEETKSASNVPSGKSTDEEEE-----AQTPQAPRTLGPSPPAPSSTP 402

Query: 1046 FPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSA 1103
             P  P   +   P    P+    AP  H  P  L   AR + PRP     PPPLI  A
Sbjct: 403  TPTAPIATLNQPPPLLRPT-LPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPA 459


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  112 bits (280), Expect = 4e-24
 Identities = 164/739 (22%), Positives = 256/739 (34%), Gaps = 85/739 (11%)

Query: 495  QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550
            ++    + Q+          SS   K +  K   A +E ++K +V+++K++  K+K    
Sbjct: 115  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 174

Query: 551  -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604
                 +  SG DN + +        T +++     +IT   A   N   ++ P   +++ 
Sbjct: 175  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 232

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
             S+ +N+ +    +E  T  K     G+  +  A+   S   +  K+     K       
Sbjct: 233  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 285

Query: 665  ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721
            +L +   K E   K       K+  P    E A+  P    +E   + +        E A
Sbjct: 286  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 341

Query: 722  EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781
              T  ++  T   P+P T   K+     PK PA      P P      P     P EP P
Sbjct: 342  PTTTKSAPTTPKEPAPTT--TKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAP 396

Query: 782  ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839
             +    APT P  PAP +P  P P  PKE        AP   +  E  P A ++ A  T 
Sbjct: 397  TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK--EPAPTAPKKPAPTTP 454

Query: 840  KAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDS 898
            K   P    E      + P+     E A  T + A    K+   +   TT  +   P++ 
Sbjct: 455  KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT---TTKSAPTTPKEP 511

Query: 899  DSSATCSADEVDEAEGGD----KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAA 954
              + T         E       K    +P+    T   +P A  + +KP      K+ A 
Sbjct: 512  SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTP-KEPAP 569

Query: 955  AIP----PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQP-----------ESDAPQQPG 999
              P    P    K+     E  APT P  PAP  P+ L P           E  AP  P 
Sbjct: 570  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 629

Query: 1000 SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPH 1059
            ++     + PAP   KE       PA     +  P  P       P    P  + + +P 
Sbjct: 630  AAAPNTPKEPAPTTPKE-------PAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 682

Query: 1060 AP--------------DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH 1105
             P              +P++ +   P    P G   T  P  P P T   P P       
Sbjct: 683  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT-PKEPAPTTPKEPAPTTPKGTA 741

Query: 1106 PSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSP 1165
            P+ L+       +  + +   P +   K P    T   P P  PK+ AP +  +    +P
Sbjct: 742  PTTLKEPAPTTPKKPAPKELAPTT--TKGPTS-TTSDKPAPTTPKETAPTTPKEPAPTTP 798

Query: 1166 RGQAGPPESLGVPTAQEAS 1184
            +  A        PT  E S
Sbjct: 799  KKPAPTTPETPPPTTSEVS 817



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%)

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
            KE      KK AP    E A   P    E    +    +     E A  T  ++  T   
Sbjct: 439  KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 495

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789
            P+P T  +  T    P P  T       P  P P     PAPT P     T   E     
Sbjct: 496  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 555

Query: 790  TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848
            T  PAP +P  P P  PK     ETA   P    ++  P   E+LA  T +   P    E
Sbjct: 556  TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 606

Query: 849  CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
                  E P      E A  T + A     KE     A T     AP      A  +  E
Sbjct: 607  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 662

Query: 909  VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968
                         +P+ +  T   +P A  +P+KP   +        + P    +     
Sbjct: 663  TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 704

Query: 969  REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
             +  APT P   AP  P  P    P+  AP  P  +     + PAP   K+       PA
Sbjct: 705  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 757

Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085
                A      P   TS  P P  P+E    +P  P P+                    P
Sbjct: 758  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 798

Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107
              P P T   PPP  S    P+
Sbjct: 799  KKPAPTTPETPPPTTSEVSTPT 820



 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 123/544 (22%), Positives = 172/544 (31%), Gaps = 108/544 (19%)

Query: 766  PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 824
            PT PP    AP  P+ AS+   + T   P PP+      V+  EE  EE +    V E +
Sbjct: 69   PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 123

Query: 825  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 867
            E    ++   +  T +  +  K+       +   K KD                  EA  
Sbjct: 124  ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 183

Query: 868  ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 901
                G  K            K   S + TTAK        P +SD+S             
Sbjct: 184  GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 243

Query: 902  ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 936
                T + ++    +G +K                        L  P P   T T  P A
Sbjct: 244  ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 302

Query: 937  NASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDA-APTKPAPPAPPPPQNLQPE 991
              +P++P      K+ A+  P    P  +      P+E A   TK AP  P  P     +
Sbjct: 303  LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 361

Query: 992  SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1051
              AP  P       ++ PAP   K A      P     A   P  P   T   P P  P+
Sbjct: 362  EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 416

Query: 1052 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1107
            E    +P  P P+    AP  P  P P      A   P  P P T   P P  +    P+
Sbjct: 417  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 476

Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1161
              +      ++        P     K AP       P T   P P  PK+ AP +  K  
Sbjct: 477  TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 536

Query: 1162 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1221
              +P+  A        PT  +                 T   P+   P ++A T    +T
Sbjct: 537  PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 584

Query: 1222 HGTP 1225
              TP
Sbjct: 585  PTTP 588



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 399  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 458

Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 459  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 515

Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 516  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 571

Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 572  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 631

Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 632  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 689

Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 690  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 734

Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 735  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 788

Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 789  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 839

Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189
                 P  L   P + G P   +P
Sbjct: 840  SAEPTPKALENSPKEPGVPTTKTP 863



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%)

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797
            K+     PK PA           PT    D PAPT P    P +    APT P  PAP +
Sbjct: 746  KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 805

Query: 798  PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844
            P  PPP       P   KE  T    P E       E  P A E    E  V T K    
Sbjct: 806  PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 865

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904
             K E T  A++   + +D      T   A K  K+      ATT + +     ++S  T 
Sbjct: 866  TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 914

Query: 905  SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964
            +  +V      D         +L T T  P+   + +K +   ++  +     P +  K 
Sbjct: 915  TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 965

Query: 965  HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023
               P++ A  +K   P P  P     +  + ++P + PR +     P P    +  P   
Sbjct: 966  ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 1022

Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062
            P        L       T+  P   P  ++++ +P + D
Sbjct: 1023 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1055



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 301  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 351

Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 352  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 406  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 460

Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 461  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 503

Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 504  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 561

Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 562  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621

Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115
            +P P      A + P   P P +    +P     P
Sbjct: 622  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 655



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 356  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 410

Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 411  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 463

Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 464  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 521

Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 522  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 575

Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 576  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 633

Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 634  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 683

Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 684  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 743

Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 744  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 800

Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 801  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 845

Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 846  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895

Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 896  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955

Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 956  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 993

Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 994  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1052



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%)

Query: 724  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782
            T   +S T   P+P T   K+T    PK PA      P P  P TPPP      T  T  
Sbjct: 766  TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 823

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
               T   +P  + P  SA P     E   +E             K PAA +  + T   +
Sbjct: 824  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 876

Query: 843  EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890
            +  + +     E   A  K     A   E T E  + A   +  S         + TT K
Sbjct: 877  KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 936

Query: 891  SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946
            ++  AP+ + +  T +  E+    E     K+R  + + +   P    +A   P+KP   
Sbjct: 937  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 993

Query: 947  KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006
            K+ K     +P ++  K    PR+    T   P   P  +  +       +P  +P  K 
Sbjct: 994  KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 1046

Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037
                P ++     E E P       VF P    +   LP  P
Sbjct: 1047 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1088


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  112 bits (280), Expect = 4e-24
 Identities = 164/739 (22%), Positives = 256/739 (34%), Gaps = 85/739 (11%)

Query: 495  QQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKE-EEKPEVENDKEDLLKEKT--- 550
            ++    + Q+          SS   K +  K   A +E ++K +V+++K++  K+K    
Sbjct: 156  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 215

Query: 551  -----DDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ-SAEL 604
                 +  SG DN + +        T +++     +IT   A   N   ++ P   +++ 
Sbjct: 216  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT--AKPINPRPSLPPNSDTSKE 273

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
             S+ +N+ +    +E  T  K     G+  +  A+   S   +  K+     K       
Sbjct: 274  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK------- 326

Query: 665  ILQQHKLKME---KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEA 721
            +L +   K E   K       K+  P    E A+  P    +E   + +        E A
Sbjct: 327  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP----KEPTPTTIKSAPTTPKEPA 382

Query: 722  EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781
              T  ++  T   P+P T   K+     PK PA      P P      P     P EP P
Sbjct: 383  PTTTKSAPTTPKEPAPTT--TKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAP 437

Query: 782  ASEATGAPTPP--PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839
             +    APT P  PAP +P  P P  PKE        AP   +  E  P A ++ A  T 
Sbjct: 438  TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK--EPAPTAPKKPAPTTP 495

Query: 840  KAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDS 898
            K   P    E      + P+     E A  T + A    K+   +   TT  +   P++ 
Sbjct: 496  KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT---TTKSAPTTPKEP 552

Query: 899  DSSATCSADEVDEAEGGD----KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAA 954
              + T         E       K    +P+    T   +P A  + +KP      K+ A 
Sbjct: 553  SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTP-KEPAP 610

Query: 955  AIP----PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQP-----------ESDAPQQPG 999
              P    P    K+     E  APT P  PAP  P+ L P           E  AP  P 
Sbjct: 611  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 670

Query: 1000 SSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPH 1059
            ++     + PAP   KE       PA     +  P  P       P    P  + + +P 
Sbjct: 671  AAAPNTPKEPAPTTPKE-------PAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 723

Query: 1060 AP--------------DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH 1105
             P              +P++ +   P    P G   T  P  P P T   P P       
Sbjct: 724  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT-PKEPAPTTPKEPAPTTPKGTA 782

Query: 1106 PSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSP 1165
            P+ L+       +  + +   P +   K P    T   P P  PK+ AP +  +    +P
Sbjct: 783  PTTLKEPAPTTPKKPAPKELAPTT--TKGPTS-TTSDKPAPTTPKETAPTTPKEPAPTTP 839

Query: 1166 RGQAGPPESLGVPTAQEAS 1184
            +  A        PT  E S
Sbjct: 840  KKPAPTTPETPPPTTSEVS 858



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%)

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
            KE      KK AP    E A   P    E    +    +     E A  T  ++  T   
Sbjct: 480  KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 536

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789
            P+P T  +  T    P P  T       P  P P     PAPT P     T   E     
Sbjct: 537  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 596

Query: 790  TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848
            T  PAP +P  P P  PK     ETA   P    ++  P   E+LA  T +   P    E
Sbjct: 597  TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 647

Query: 849  CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
                  E P      E A  T + A     KE     A T     AP      A  +  E
Sbjct: 648  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 703

Query: 909  VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968
                         +P+ +  T   +P A  +P+KP   +        + P    +     
Sbjct: 704  TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 745

Query: 969  REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
             +  APT P   AP  P  P    P+  AP  P  +     + PAP   K+       PA
Sbjct: 746  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 798

Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085
                A      P   TS  P P  P+E    +P  P P+                    P
Sbjct: 799  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 839

Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107
              P P T   PPP  S    P+
Sbjct: 840  KKPAPTTPETPPPTTSEVSTPT 861



 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 123/544 (22%), Positives = 172/544 (31%), Gaps = 108/544 (19%)

Query: 766  PTPPPEDIPAPTEPTPASEATGAPTP-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGE 824
            PT PP    AP  P+ AS+   + T   P PP+      V+  EE  EE +    V E +
Sbjct: 110  PTSPPSSKKAP-PPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS----VSENQ 164

Query: 825  EQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD-----------------AEAAE 867
            E    ++   +  T +  +  K+       +   K KD                  EA  
Sbjct: 165  ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 224

Query: 868  ATAEGALKA---------EKKEGGSGRATTAK----SSGAPQDSDSS------------- 901
                G  K            K   S + TTAK        P +SD+S             
Sbjct: 225  GLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV 284

Query: 902  ---ATCSADEVDEAEGGDKNR----------------------LLSPRPSLLTPTGDPRA 936
                T + ++    +G +K                        L  P P   T T  P A
Sbjct: 285  ETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP-A 343

Query: 937  NASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDA-APTKPAPPAPPPPQNLQPE 991
              +P++P      K+ A+  P    P  +      P+E A   TK AP  P  P     +
Sbjct: 344  LTTPKEPTPTTP-KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTK 402

Query: 992  SDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPR 1051
              AP  P       ++ PAP   K A      P     A   P  P   T   P P  P+
Sbjct: 403  EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP-----APTTPKKPAPTTPKEPAPTTPK 457

Query: 1052 EVIKASPHAPDPSAFSYAP--PGHPLPLGLHDTA--RPVLPRPPTISNPPPLISSAKHPS 1107
            E    +P  P P+    AP  P  P P      A   P  P P T   P P  +    P+
Sbjct: 458  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 517

Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAK-APV-----GPVTMGLPLPMDPKKLAPFSGVKQE 1161
              +      ++        P     K AP       P T   P P  PK+ AP +  K  
Sbjct: 518  TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA 577

Query: 1162 QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSIT 1221
              +P+  A        PT  +                 T   P+   P ++A T    +T
Sbjct: 578  PTTPKEPAPTTPKEPAPTTTKKP------------APTTPKEPAPTTPKETAPTTPKKLT 625

Query: 1222 HGTP 1225
              TP
Sbjct: 626  PTTP 629



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 440  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 499

Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 500  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 556

Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 557  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 612

Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 613  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 672

Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 673  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 730

Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 731  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 775

Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 776  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 829

Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 830  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 880

Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189
                 P  L   P + G P   +P
Sbjct: 881  SAEPTPKALENSPKEPGVPTTKTP 904



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%)

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797
            K+     PK PA           PT    D PAPT P    P +    APT P  PAP +
Sbjct: 787  KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 846

Query: 798  PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844
            P  PPP       P   KE  T    P E       E  P A E    E  V T K    
Sbjct: 847  PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 906

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904
             K E T  A++   + +D      T   A K  K+      ATT + +     ++S  T 
Sbjct: 907  TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 955

Query: 905  SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964
            +  +V      D         +L T T  P+   + +K +   ++  +     P +  K 
Sbjct: 956  TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 1006

Query: 965  HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023
               P++ A  +K   P P  P     +  + ++P + PR +     P P    +  P   
Sbjct: 1007 ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 1063

Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062
            P        L       T+  P   P  ++++ +P + D
Sbjct: 1064 PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1096



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 342  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 392

Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 393  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 447  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 501

Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 502  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 544

Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 545  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 602

Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 603  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662

Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115
            +P P      A + P   P P +    +P     P
Sbjct: 663  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 696



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 397  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 451

Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 452  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 504

Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 505  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 562

Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 563  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 616

Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 617  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 674

Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 675  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 724

Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 725  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 784

Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 785  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 841

Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 842  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 886

Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 887  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936

Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 937  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996

Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 997  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 1034

Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 1035 -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1093



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%)

Query: 724  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782
            T   +S T   P+P T   K+T    PK PA      P P  P TPPP      T  T  
Sbjct: 807  TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 864

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
               T   +P  + P  SA P     E   +E             K PAA +  + T   +
Sbjct: 865  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 917

Query: 843  EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890
            +  + +     E   A  K     A   E T E  + A   +  S         + TT K
Sbjct: 918  KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 977

Query: 891  SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946
            ++  AP+ + +  T +  E+    E     K+R  + + +   P    +A   P+KP   
Sbjct: 978  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 1034

Query: 947  KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006
            K+ K     +P ++  K    PR+    T   P   P  +  +       +P  +P  K 
Sbjct: 1035 KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 1087

Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037
                P ++     E E P       VF P    +   LP  P
Sbjct: 1088 VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1129


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  106 bits (264), Expect = 3e-22
 Identities = 161/707 (22%), Positives = 241/707 (34%), Gaps = 87/707 (12%)

Query: 518  EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577
            E KD K K +  +K   KP V ++            SG DN + +        T +++  
Sbjct: 65   EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 113

Query: 578  RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636
               +IT   A   N   ++ P   +++  S+ +N+ +    +E  T  K     G+  + 
Sbjct: 114  TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 171

Query: 637  IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693
             A+   S   +  K+     K       +L +   K E   K       K+  P    E 
Sbjct: 172  SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 224

Query: 694  AAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPP 753
            A+  P    +E   + +        E A  T  ++  T   P+P T   K+     PK P
Sbjct: 225  ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTT--TKEPAPTTPKEP 278

Query: 754  ATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPVVPKEEKE 811
            A      P P      P     P EP P +    APT P  PAP +P  P P  PKE   
Sbjct: 279  APTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 335

Query: 812  EETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATA 870
                 AP   +  E  P A ++ A  T K   P    E      + P+     E A  T 
Sbjct: 336  TTKEPAPTTPK--EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTT 393

Query: 871  EGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGD----KNRLLSPRPS 926
            + A    K+   +   TT  +   P++   + T         E       K    +P+  
Sbjct: 394  KSAPTTTKEPAPT---TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 450

Query: 927  LLTPTGDPRANASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDAAPTKPAPPAP 982
              T   +P A  + +KP      K+ A   P    P    K+     E  APT P  PAP
Sbjct: 451  APTTPKEP-APTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 508

Query: 983  PPPQNLQP-----------ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031
              P+ L P           E  AP  P ++     + PAP   KE       PA     +
Sbjct: 509  TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------PAPTTPKE 561

Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAP--------------DPSAFSYAPPGHPLPL 1077
              P  P       P    P  + + +P  P              +P++ +   P    P 
Sbjct: 562  PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 621

Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137
            G   T  P  P P T   P P       P+ L+       +  + +   P +   K P  
Sbjct: 622  GTAPTT-PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTS 678

Query: 1138 PVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184
              T   P P  PK+ AP +  +    +P+  A        PT  E S
Sbjct: 679  -TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 724



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%)

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
            KE      KK AP    E A   P    E    +    +     E A  T  ++  T   
Sbjct: 346  KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 402

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789
            P+P T  +  T    P P  T       P  P P     PAPT P     T   E     
Sbjct: 403  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 462

Query: 790  TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848
            T  PAP +P  P P  PK     ETA   P    ++  P   E+LA  T +   P    E
Sbjct: 463  TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 513

Query: 849  CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
                  E P      E A  T + A     KE     A T     AP      A  +  E
Sbjct: 514  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 569

Query: 909  VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968
                         +P+ +  T   +P A  +P+KP   +        + P    +     
Sbjct: 570  TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 611

Query: 969  REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
             +  APT P   AP  P  P    P+  AP  P  +     + PAP   K+       PA
Sbjct: 612  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 664

Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085
                A      P   TS  P P  P+E    +P  P P+                    P
Sbjct: 665  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 705

Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107
              P P T   PPP  S    P+
Sbjct: 706  KKPAPTTPETPPPTTSEVSTPT 727



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 306  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 365

Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 366  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 422

Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 423  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 478

Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 479  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 538

Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 539  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 596

Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 597  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 641

Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 642  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 695

Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 696  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 746

Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189
                 P  L   P + G P   +P
Sbjct: 747  SAEPTPKALENSPKEPGVPTTKTP 770



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%)

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797
            K+     PK PA           PT    D PAPT P    P +    APT P  PAP +
Sbjct: 653  KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 712

Query: 798  PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844
            P  PPP       P   KE  T    P E       E  P A E    E  V T K    
Sbjct: 713  PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 772

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904
             K E T  A++   + +D      T   A K  K+      ATT + +     ++S  T 
Sbjct: 773  TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 821

Query: 905  SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964
            +  +V      D         +L T T  P+   + +K +   ++  +     P +  K 
Sbjct: 822  TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 872

Query: 965  HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023
               P++ A  +K   P P  P     +  + ++P + PR +     P P    +  P   
Sbjct: 873  ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 929

Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062
            P        L       T+  P   P  ++++ +P + D
Sbjct: 930  PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 962



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 208  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 258

Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 259  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 312

Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 313  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 367

Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 368  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 410

Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 411  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 468

Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 469  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528

Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115
            +P P      A + P   P P +    +P     P
Sbjct: 529  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 562



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 263  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 317

Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 318  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 370

Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 371  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 428

Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 429  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 482

Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 483  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 540

Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 541  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 590

Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 591  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 650

Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 651  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 707

Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 708  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 752

Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 753  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802

Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 803  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 862

Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 863  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 900

Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 901  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 959



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%)

Query: 724  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782
            T   +S T   P+P T   K+T    PK PA      P P  P TPPP      T  T  
Sbjct: 673  TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 730

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
               T   +P  + P  SA P     E   +E             K PAA +  + T   +
Sbjct: 731  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 783

Query: 843  EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890
            +  + +     E   A  K     A   E T E  + A   +  S         + TT K
Sbjct: 784  KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 843

Query: 891  SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946
            ++  AP+ + +  T +  E+    E     K+R  + + +   P    +A   P+KP   
Sbjct: 844  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 900

Query: 947  KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006
            K+ K     +P ++  K    PR+    T   P   P  +  +       +P  +P  K 
Sbjct: 901  KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 953

Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037
                P ++     E E P       VF P    +   LP  P
Sbjct: 954  VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 995


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  106 bits (264), Expect = 3e-22
 Identities = 161/707 (22%), Positives = 241/707 (34%), Gaps = 87/707 (12%)

Query: 518  EEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGR 577
            E KD K K +  +K   KP V ++            SG DN + +        T +++  
Sbjct: 106  EVKDNK-KNRTKKKPTPKPPVVDEAG----------SGLDNGDFKVTTPDTSTTQHNKVS 154

Query: 578  RKGRITRSMANEANSEEAITPQQ-SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSA 636
               +IT   A   N   ++ P   +++  S+ +N+ +    +E  T  K     G+  + 
Sbjct: 155  TSPKITT--AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 212

Query: 637  IARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKME---KERNARRKKKKAPAAASEE 693
             A+   S   +  K+     K       +L +   K E   K       K+  P    E 
Sbjct: 213  SAKETQSIEKTSAKDLAPTSK-------VLAKPTPKAETTTKGPALTTPKEPTPTTPKEP 265

Query: 694  AAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPP 753
            A+  P    +E   + +        E A  T  ++  T   P+P T   K+     PK P
Sbjct: 266  ASTTP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTT--TKEPAPTTPKEP 319

Query: 754  ATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP--PAPPSPSAPPPVVPKEEKE 811
            A      P P      P     P EP P +    APT P  PAP +P  P P  PKE   
Sbjct: 320  APTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 376

Query: 812  EETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATA 870
                 AP   +  E  P A ++ A  T K   P    E      + P+     E A  T 
Sbjct: 377  TTKEPAPTTPK--EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTT 434

Query: 871  EGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGD----KNRLLSPRPS 926
            + A    K+   +   TT  +   P++   + T         E       K    +P+  
Sbjct: 435  KSAPTTTKEPAPT---TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 491

Query: 927  LLTPTGDPRANASPQKPLDLKQLKQRAAAIP----PIQVTKVHEPPREDAAPTKPAPPAP 982
              T   +P A  + +KP      K+ A   P    P    K+     E  APT P  PAP
Sbjct: 492  APTTPKEP-APTTTKKPAPTTP-KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP 549

Query: 983  PPPQNLQP-----------ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031
              P+ L P           E  AP  P ++     + PAP   KE       PA     +
Sbjct: 550  TTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE-------PAPTTPKE 602

Query: 1032 KLPGDPPCWTSGLPFPVPPREVIKASPHAP--------------DPSAFSYAPPGHPLPL 1077
              P  P       P    P  + + +P  P              +P++ +   P    P 
Sbjct: 603  PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 662

Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137
            G   T  P  P P T   P P       P+ L+       +  + +   P +   K P  
Sbjct: 663  GTAPTT-PKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT--TKGPTS 719

Query: 1138 PVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184
              T   P P  PK+ AP +  +    +P+  A        PT  E S
Sbjct: 720  -TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 765



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 111/442 (25%), Positives = 142/442 (32%), Gaps = 69/442 (15%)

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESI 734
            KE      KK AP    E A   P    E    +    +     E A  T  ++  T   
Sbjct: 387  KEPAPTAPKKPAPTTPKEPA---PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 443

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP-----TPASEATGAP 789
            P+P T  +  T    P P  T       P  P P     PAPT P     T   E     
Sbjct: 444  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 503

Query: 790  TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP-VKSE 848
            T  PAP +P  P P  PK     ETA   P    ++  P   E+LA  T +   P    E
Sbjct: 504  TKKPAPTTPKEPAPTTPK-----ETAPTTP----KKLTPTTPEKLAPTTPEKPAPTTPEE 554

Query: 849  CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
                  E P      E A  T + A     KE     A T     AP      A  +  E
Sbjct: 555  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTPKE 610

Query: 909  VDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968
                         +P+ +  T   +P A  +P+KP   +        + P    +     
Sbjct: 611  TAPT---------TPKGTAPTTLKEP-APTTPKKPAPKE--------LAPTTTKEPTSTT 652

Query: 969  REDAAPTKP---APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
             +  APT P   AP  P  P    P+  AP  P  +     + PAP   K+       PA
Sbjct: 653  CDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKK-------PA 705

Query: 1026 FAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARP 1085
                A      P   TS  P P  P+E    +P  P P+                    P
Sbjct: 706  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTT-------------------P 746

Query: 1086 VLPRPPTISNPPPLISSAKHPS 1107
              P P T   PPP  S    P+
Sbjct: 747  KKPAPTTPETPPPTTSEVSTPT 768



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 110/504 (21%), Positives = 159/504 (31%), Gaps = 82/504 (16%)

Query: 1729 PHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERE 1788
            P  P    P    P T  +     P  P P +   + +      PT   KP  T+  E  
Sbjct: 347  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 406

Query: 1789 RDRDRERDRDREREKSILT----STTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844
                +E      +E S  T    + TT + AP     T++ + ++  S         P +
Sbjct: 407  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT---TKEPAPTTTKSAPTTPKEPSPTT 463

Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATF 1904
                   +P  P      +  P+    T  +   T  +   PT  +  + ++P  PA T 
Sbjct: 464  TKEPAPTTPKEPAPTTPKKPAPT----TPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 519

Query: 1905 PPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV--------------ARPERPRADTGHAF 1950
            P  T       L    P  + P    K AP                  PE P   T  A 
Sbjct: 520  PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAA 579

Query: 1951 L----AKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART-PAKNLAPHHASPDPPAP 2005
                  +P   +  EPA  P+   EP P  P  +   T   T P     P   +P  PAP
Sbjct: 580  APNTPKEPAPTTPKEPA--PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 637

Query: 2006 PASASDPHREKTQS---KPFSIQELELRSLGYHGSSYSPEGVEPVSP-------VSSPSL 2055
               A    +E T +   KP               +  +P+G  P +P          P+ 
Sbjct: 638  KELAPTTTKEPTSTTCDKP---------------APTTPKGTAPTTPKEPAPTTPKEPAP 682

Query: 2056 THDKG-LPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHL----RPLPESQPSSSPL 2110
            T  KG  P  L+E           PK+P P +L       P      +P P +   ++P 
Sbjct: 683  TTPKGTAPTTLKE------PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 736

Query: 2111 -----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVL 2165
                   T P         T     SEV T   T+          P  ++  P  S P L
Sbjct: 737  TPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE---------PTTIHKSPDESTPEL 787

Query: 2166 DLRRPPSDLYLPPPDHGAPARGSP 2189
                 P  L   P + G P   +P
Sbjct: 788  SAEPTPKALENSPKEPGVPTTKTP 811



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 81/339 (23%), Positives = 121/339 (35%), Gaps = 48/339 (14%)

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP---TPASEATGAPTPP--PAPPS 797
            K+     PK PA           PT    D PAPT P    P +    APT P  PAP +
Sbjct: 694  KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTT 753

Query: 798  PSAPPPV-----VPKEEKEEETAAAPPVEE----GEEQKPPAAE----ELAVDTGKAEEP 844
            P  PPP       P   KE  T    P E       E  P A E    E  V T K    
Sbjct: 754  PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 813

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATC 904
             K E T  A++   + +D      T   A K  K+      ATT + +     ++S  T 
Sbjct: 814  TKPEMTTTAKDKTTE-RDLRTTPETTTAAPKMTKE-----TATTTEKT-----TESKITA 862

Query: 905  SADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKV 964
            +  +V      D         +L T T  P+   + +K +   ++  +     P +  K 
Sbjct: 863  TTTQVTSTTTQDTTPF--KITTLKTTTLAPKVTTT-KKTITTTEIMNK-----PEETAK- 913

Query: 965  HEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP-PADKEAEKPVFF 1023
               P++ A  +K   P P  P     +  + ++P + PR +     P P    +  P   
Sbjct: 914  ---PKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN 970

Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD 1062
            P        L       T+  P   P  ++++ +P + D
Sbjct: 971  PTSRIAEAMLQ------TTTRPNQTPNSKLVEVNPKSED 1003



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 89/395 (22%), Positives = 141/395 (35%), Gaps = 51/395 (12%)

Query: 1732 PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR 1791
            P L  P   TP T  +  +  P  P P + +  S+P +P  P     PTTT S+      
Sbjct: 249  PALTTPKEPTPTTPKEPASTTPKEPTPTTIK--SAPTTPKEPA----PTTTKSAP---TT 299

Query: 1792 DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQH 1851
             +E      +E +    TT  E AP     T++ + ++  S         P +       
Sbjct: 300  PKEPAPTTTKEPA---PTTPKEPAP---TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 353

Query: 1852 SPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFP--PATH 1909
            +P  P      +  P+    T  +   T  EP+ PT  +  + ++P +PA T P  PA  
Sbjct: 354  TPKEPAPTTPKEPTPT----TPKEPAPTTKEPA-PTTPKEPAPTAPKKPAPTTPKEPAPT 408

Query: 1910 CPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKG 1969
             P             EP     + P    P+ P   T      K    +  EPA + +K 
Sbjct: 409  TP------------KEPAPTTTKEPSPTTPKEPAPTT-----TKSAPTTTKEPAPTTTKS 451

Query: 1970 SEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-------PASASDPHREKTQSKPF 2022
            +   P  P  +     A T  K  AP   +P  PAP       P +  +P    T+    
Sbjct: 452  APTTPKEPSPTTTKEPAPTTPKEPAP--TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 509

Query: 2023 SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLE--GELRPK 2080
            +  +    +     +  +P+ + P +P      T +K  P   EEL  +  E      P+
Sbjct: 510  TTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569

Query: 2081 QPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAP 2115
            +P P      A + P   P P +    +P     P
Sbjct: 570  EPAPTTPKAAAPNTPK-EPAPTTPKEPAPTTPKEP 603



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 155/780 (19%), Positives = 236/780 (30%), Gaps = 127/780 (16%)

Query: 1549 SPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRG 1608
            +P TT+EP P   +    ++        T +     K P  T P+  P P +P E     
Sbjct: 304  APTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK-KPAPTTPKEP---- 358

Query: 1609 VSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPN------PTYPHLYPPYLIR 1662
                       P    PT+     P     A   P+  AP       PT P    P   +
Sbjct: 359  -------APTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 411

Query: 1663 GYPDTAALENRQTIINDYI-TSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRG 1721
                T   E   T   +   T+ +         A         +P+E S        P  
Sbjct: 412  EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP-- 469

Query: 1722 IIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLT-KPT 1780
                   P  P    P    P T  +     P  P P +++   +P +P  P   T K T
Sbjct: 470  -----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK-KPAPTTPKEPAPTTPKET 523

Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIW----RPGTEQSSGSSGSSGGGG 1836
              ++ ++      E+      EK     TT  E AP       P T +    +       
Sbjct: 524  APTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 581

Query: 1837 GSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSS 1896
             +   PA        +P  P      +  P+    T      T  + + PT L+  + ++
Sbjct: 582  NTPKEPA------PTTPKEPAPTTPKEPAPTTPKETAP----TTPKGTAPTTLKEPAPTT 631

Query: 1897 PVRPA--ATFPPATHCPLGGTLDGVYPTLME---PVLLPKEAPRVARPERPRADTGHA-- 1949
            P +PA     P  T  P   T D   PT  +   P    + AP   +   P    G A  
Sbjct: 632  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT 691

Query: 1950 -------FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002
                      K PA   L P ++    S       P +   T   TP +   P   +P  
Sbjct: 692  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE---PAPTTPKK 748

Query: 2003 PAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLP 2062
            PAP    + P      S P + +E              P  +      S+P L+ +   P
Sbjct: 749  PAPTTPETPPPTTSEVSTPTTTKE--------------PTTIHKSPDESTPELSAEP-TP 793

Query: 2063 KHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPH-------------LRPLPE---SQPS 2106
            K LE            PK+PG       AA  P              LR  PE   + P 
Sbjct: 794  KALEN----------SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843

Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166
             +    T        ++      ++   TQD T      L     AP  +    +    +
Sbjct: 844  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 903

Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG 2226
            +   P +    P D    ++ +        +P+P K            P   P+  T   
Sbjct: 904  IMNKPEET-AKPKDRATNSKAT--------TPKPQK------------PTKAPKKPTST- 941

Query: 2227 HSRSAVYPLLYRDGEQTEPSRMGSKSP--GNTSQPPAFFSKLTESNSAMVKSKKQEINKK 2284
              +    P + +      P +M S  P    TS+      + T   +    SK  E+N K
Sbjct: 942  -KKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1000



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 80/342 (23%), Positives = 120/342 (35%), Gaps = 47/342 (13%)

Query: 724  TVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP-TPPPEDIPAPTEPTPA 782
            T   +S T   P+P T   K+T    PK PA      P P  P TPPP      T  T  
Sbjct: 714  TKGPTSTTSDKPAPTTP--KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK 771

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
               T   +P  + P  SA P     E   +E             K PAA +  + T   +
Sbjct: 772  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGV-------PTTKTPAATKPEMTTTAKD 824

Query: 843  EPVKSECTEEAEEGPAKGK----DAEAAEATAEGALKAEKKEGGSG--------RATTAK 890
            +  + +     E   A  K     A   E T E  + A   +  S         + TT K
Sbjct: 825  KTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 884

Query: 891  SSG-APQDSDSSATCSADEV---DEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 946
            ++  AP+ + +  T +  E+    E     K+R  + + +   P    +A   P+KP   
Sbjct: 885  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKA---PKKPTST 941

Query: 947  KQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKS 1006
            K+ K     +P ++  K    PR+    T   P   P  +  +       +P  +P  K 
Sbjct: 942  KKPK----TMPRVRKPKTTPTPRK---MTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKL 994

Query: 1007 RSPAPPAD----KEAEKP-------VFFPAFAAEAQKLPGDP 1037
                P ++     E E P       VF P    +   LP  P
Sbjct: 995  VEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVP 1036


>gi|7661892 REST corepressor 1 [Homo sapiens]
          Length = 482

 Score =  105 bits (262), Expect = 5e-22
 Identities = 74/285 (25%), Positives = 134/285 (47%), Gaps = 19/285 (6%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K F  I   L  K++A  V +YY  KK     S++ R  R++ 
Sbjct: 192 WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQ- 250

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDK-----EDLL 546
             +++++ + + ++     P+     E    KE +KE    E  P+V+ +K     ++  
Sbjct: 251 -KREREESEDELEEANGNNPI---DIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRA 306

Query: 547 KEKTDD---TSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAE 603
           K K       S ED +   A A+               + R + N   +  A+  +    
Sbjct: 307 KRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGG 366

Query: 604 LASMELNE-----SSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKK 658
           +    L E     ++RWT EE   A + + ++GR++ AI+ ++G+K+V Q KNF+ NY++
Sbjct: 367 IEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRR 426

Query: 659 RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDE 703
           R N+DE+LQ+ + +  KE       +K P  + + +   P  EDE
Sbjct: 427 RFNIDEVLQEWEAEHGKEETNGPSNQK-PVKSPDNSIKMPEEEDE 470


>gi|27734799 REST corepressor 2 [Homo sapiens]
          Length = 523

 Score =  103 bits (256), Expect = 3e-21
 Identities = 99/393 (25%), Positives = 165/393 (41%), Gaps = 29/393 (7%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K F  I   L  K +   V YYY  KK  +  S++ R  RR G
Sbjct: 135 WTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLG 194

Query: 492 KSQQQQQQQQQQQQQ---QQQQPMPRSSQEEK-DEKEKEKEAEKEEEKPEVENDKEDLLK 547
             + ++   + ++ +    + +P P   + E    +         +++ +V   +   L+
Sbjct: 195 GRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLR 254

Query: 548 EKTDDTSGEDNDEKEAVASKGR--------KTANSQGRRKGRITRSMANEANS-----EE 594
            +     G     +   A  G         +  +SQ     R  +SM    +S     E 
Sbjct: 255 TRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEG 314

Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654
            I P +  E A+ + N  SRWT +E   A + +  +G+++ AIA ++G+KT++Q K F+ 
Sbjct: 315 GIDPLRPPE-ANTKFN--SRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFV 371

Query: 655 NYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNE 714
           +Y++R NL+E+LQ+ + + +    A    ++A   A   A  P + ED+E++ + VS + 
Sbjct: 372 SYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPA--PALEEDDEVQITSVSTSV 429

Query: 715 EEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATLGADGPPPGPPTPPPED 772
              V  A       +   S P P       T        PP   G    P   P  PP  
Sbjct: 430 PRSVPPAPPPPPPPTSL-SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPP 488

Query: 773 IPAPTEPTPASEATGAPTPPP----APPSPSAP 801
           +  P    P   A   P PPP    AP  P AP
Sbjct: 489 LIRPALAAPRHSARPGPQPPPTLIGAPLEPPAP 521



 Score = 38.5 bits (88), Expect = 0.082
 Identities = 41/147 (27%), Positives = 58/147 (39%), Gaps = 34/147 (23%)

Query: 937  NASPQKPLDLKQLKQRAAAIPP-------IQVTKVHEP-PREDAAPTKPAPPAPPPPQNL 988
            + +P  P+ +++ ++ A    P       +Q+T V    PR       PAPP PPPP +L
Sbjct: 391  DGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRS----VPPAPPPPPPPTSL 446

Query: 989  Q--------PESDAP---QQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDP 1037
                     P   AP   +QP    +G+   P   A  +   P+  PA AA         
Sbjct: 447  SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPR-LAPNQPPPPLIRPALAAPRH------ 499

Query: 1038 PCWTSGLPFPVPPREVIKASPHAPDPS 1064
                S  P P PP  +I A    P PS
Sbjct: 500  ----SARPGPQPPPTLIGAPLEPPAPS 522



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 3/95 (3%)

Query: 740 EAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPP-SP 798
           EA +D     P P        P P P     +++   +  T    +     PPP PP S 
Sbjct: 387 EAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSL 446

Query: 799 SAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAA 831
           S PPP++  P           PP+++G   +P  A
Sbjct: 447 SQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLA 481



 Score = 32.3 bits (72), Expect = 5.9
 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 11/51 (21%)

Query: 1050 PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPT-ISNPPPL 1099
            PR V  A P  P P++ S  PP            RP LP  PT +  PPPL
Sbjct: 430  PRSVPPAPPPPPPPTSLSQPPP----------LLRPPLPTAPTLLRQPPPL 470


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  101 bits (251), Expect = 1e-20
 Identities = 171/774 (22%), Positives = 293/774 (37%), Gaps = 112/774 (14%)

Query: 293  QWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQS 352
            Q E+ F  R D+L EA   KV    N    R+ + ++ EY          +R+LQ R   
Sbjct: 288  QSEEWFRVRLDRLSEA--AKV----NTDAMRSAQEEITEY----------RRQLQARTTE 331

Query: 353  RVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINM 412
                + +  S+   RSE E     D  S QE +++             DA+ +  K+   
Sbjct: 332  LEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ------------LDAELRNTKWE-- 377

Query: 413  NGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQH-------PKNFGLIASFLERKTVAE 465
               MA  ++ Y+D   + M  + E   +R+            P  F L     +  +V+ 
Sbjct: 378  ---MAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVST 434

Query: 466  CVLY-----YYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEK 520
             +         + +K+E    +V         +++  ++++++ ++++ +      +EE 
Sbjct: 435  HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494

Query: 521  DEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKG 580
            +  E+E ++   EE    E + +  +KE+    +   + EKE   S     +  + +   
Sbjct: 495  EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554

Query: 581  RITRSMANEANSEEAITPQQSAELASMELNESSRWTE-------EEMETAKKGLLEHGRN 633
            +       EA S E    +  AE+ S E  +S    E       +  E AK  + E  ++
Sbjct: 555  KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614

Query: 634  WSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKK-----KAPA 688
             +     V  +  S  +       K    +E     K K  ++  A+  +K     KA A
Sbjct: 615  PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 689  AASEEAAFPPVVEDEEME-ASGVSGNEEEMVEEAEATVNNSSDT-ESIPSPHTEAAKDTG 746
             + E+A  P   E +  E A      E +  E+A++ V   + + E   SP  E AK   
Sbjct: 675  KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734

Query: 747  QNGPKPPATLGADGP--PPGPPTPPPEDIPAPTEPTPASEATGAPTP--PPAPPSPSAPP 802
            +   K P    A  P     P      D+ +P   TPA E   +P    P    SP    
Sbjct: 735  K--AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792

Query: 803  PVVPKEEKE--EETAAAPPVE--EGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPA 858
               P++ K   +E A AP  E  + EE K P  EE      K +EP K     E E+ PA
Sbjct: 793  VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK---AEEEKAPA 849

Query: 859  KGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 918
              K  E  ++  E   +A KKE    +    K     +  +S       E  + E  DK 
Sbjct: 850  TPKTEEKKDSKKE---EAPKKEAPKPKVEEKKEPAVEKPKESKV-----EAKKEEAEDKK 901

Query: 919  RLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDA---APT 975
            ++         PT +  A A  +   D K          P + T+V +   +DA    P+
Sbjct: 902  KV---------PTPEKEAPAKVEVKEDAK----------PKEKTEVAKKEPDDAKAKEPS 942

Query: 976  KPAPPAPPPPQNLQPESDAPQQPGSSPRGK----------SRSPAPPADKEAEK 1019
            KPA      P+    + +  ++P   P+ +          S+ P+ P  ++AEK
Sbjct: 943  KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK 996



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 106/423 (25%), Positives = 167/423 (39%), Gaps = 63/423 (14%)

Query: 670  KLKMEKERNARRKKKKAPAAASEEA----AFPPVVEDEEMEASGVSGNEEEMVEEAEATV 725
            K+K E++     K +K      E+         V E+EE EA    G EEE  EE EA  
Sbjct: 437  KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE- 495

Query: 726  NNSSDTESIP-----SPHTEA-------------AKDTGQNGPKPPATLG----ADGP-- 761
                +T+S P     SP  EA             AK   +   K PA +     A  P  
Sbjct: 496  GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555

Query: 762  -----PPGPPTPPPEDIPAPTE-------PTPASEATGAPTPPPAPPSPSAPPPVVPKEE 809
                 PP   +P  E+  +P E        +PA E   +P    +P    +P     KEE
Sbjct: 556  EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV----KEE 611

Query: 810  KEEETAAAPPVEE-----GEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE 864
             +    A  PV+E      E + P  A+    +  K+ E  KS   EEA+  P K K   
Sbjct: 612  AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS-PEKAKSPV 670

Query: 865  AAEAT----AEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRL 920
             AEA     A+  +KAE K     ++   + + +P+ + S     A   ++A+   K   
Sbjct: 671  KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730

Query: 921  LSPRPS---LLTPTGDPRANASPQKP--LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPT 975
             +P  +   +      P    SP+K   LD+K  + +  A    + +   + P +  +P 
Sbjct: 731  KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR-SPADKFPEKAKSPV 789

Query: 976  KPAPPAPPPPQN-LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034
            K    +P   ++ L+ ++ AP++     + + +SP    +K  E  V  P   AE +K P
Sbjct: 790  KEEVKSPEKAKSPLKEDAKAPEKE-IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP 848

Query: 1035 GDP 1037
              P
Sbjct: 849  ATP 851



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 100/454 (22%), Positives = 163/454 (35%), Gaps = 53/454 (11%)

Query: 498  QQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGED 557
            ++ +   +++ + P    S E+     KE+     E K  V+ + +   + K+ + +   
Sbjct: 582  EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 558  NDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTE 617
              E+     K +     + +   +    +  EA S E       AE  S E  +S    E
Sbjct: 642  TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701

Query: 618  EEM-ETAKKGLLEHGRNWSAIARMVG--SKTVSQCKNFYFNYKKRQNLDEILQQHK---L 671
             +  E AK  + E  ++       V   +KT  + K+      K     +  ++ K   +
Sbjct: 702  AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761

Query: 672  KMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT 731
            K  + +   +++ ++PA    E A  PV E+ +      S     + E+A+A        
Sbjct: 762  KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS----PLKEDAKAPEKEIPKK 817

Query: 732  ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTP 791
            E + SP  E  K       +PP     +  P  P T   +D  +  E  P  EA   P P
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD--SKKEEAPKKEA---PKP 872

Query: 792  P------PAPPSPSAPPPVVPKEEKEEETAAAPP-------VEEGEEQKPPAAEELAV-- 836
                   PA   P        KEE E++     P       VE  E+ KP    E+A   
Sbjct: 873  KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE 932

Query: 837  -DTGKAEEP---------------VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKE 880
             D  KA+EP                K E  ++ EE P         EA A+   K   KE
Sbjct: 933  PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKP-------KTEAKAKEDDKTLSKE 985

Query: 881  GGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914
                +A  A+ S +    DS     A E   A+G
Sbjct: 986  PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 107/575 (18%), Positives = 220/575 (38%), Gaps = 59/575 (10%)

Query: 79  SQELHLRPESHSYLPELGKSEME--FIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLT 136
           S   H++ +S   +  + KSE E   +E +    ++  +            +    E   
Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490

Query: 137 KDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKK 196
           ++ +  G+ E  SPP+     PE E   P   + +        ++E      ++   +K 
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550

Query: 197 QQQLEEEAAKPPE---PEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGP--- 250
           +   +EEA  PPE   PEK  +  P E K     +    E  K    A    +   P   
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 251 ------QVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQ 304
                 + + P+  +     +     K     +++     K ++  ++  E K  ++   
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE--EAKSPEKAKS 668

Query: 305 LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMS 364
            ++A  K  E+ ++  +  AK        EK    ++++ +  E+ +S V +        
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSP------EKAKSPVKEEAKSPEKAKSPVKE-------E 715

Query: 365 AARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYK 424
           A   E   S + +     E  +  +++ A  P        ++ K +++    A      +
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA--KSPEKAKTLDVKSPEAKTPAKEE 773

Query: 425 DRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484
            R   + + E+ K   +E+     K      S L+    A         +K    K  V+
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEK----AKSPLKEDAKA--------PEKEIPKKEEVK 821

Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE- 543
              +   K Q+ + ++  ++ ++++ P    ++E+KD K KE+  +KE  KP+VE  KE 
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPKVEEKKEP 880

Query: 544 ----------DLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSE 593
                     +  KE+ +D       EKEA A K     +++ + K  + +   ++A ++
Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA-KVEVKEDAKPKEKTEVAKKEPDDAKAK 939

Query: 594 EAITPQQSAELASMELN---ESSRWTEEEMETAKK 625
           E   P +  E A  + +   E ++  EE+ +T  K
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 79/400 (19%), Positives = 144/400 (36%), Gaps = 38/400 (9%)

Query: 473  TKKNENYKSLVRRSYRRRGKSQQQQQ---QQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA 529
            TK+        +   +   KS ++ +   + + +  ++ + P+   ++  +  K   KE 
Sbjct: 642  TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701

Query: 530  EKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANE 589
             K  EK +    +E    EK      E+    E   S  ++ A S  + K    ++   +
Sbjct: 702  AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTLD 760

Query: 590  ANSEEAITP--QQSAELASMELNESSRWTEEEM---ETAKKGLLEHGRNWSAIARMVGSK 644
              S EA TP  +++   A     ++    +EE+   E AK  L E  +           K
Sbjct: 761  VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK--------APEK 812

Query: 645  TVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNA-------RRKKKKAPAAASEEAAFP 697
             + + +      K+ +   E+  +   K  +E  A        +K  K   A  +EA  P
Sbjct: 813  EIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872

Query: 698  PVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEA-AKDTGQNGPKPPATL 756
             V E +E         E+    + EA    + D + +P+P  EA AK   +   KP    
Sbjct: 873  KVEEKKEPAV------EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926

Query: 757  GADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAA 816
                         P+D  A     PA +   AP         +  P   PK E + +   
Sbjct: 927  EV-------AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979

Query: 817  APPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEG 856
                +E  + K   AE+ +    K  +P +    ++A +G
Sbjct: 980  KTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 129/565 (22%), Positives = 200/565 (35%), Gaps = 97/565 (17%)

Query: 1756 PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHA 1815
            P PFS      P  P   TH+   +       E+        + + E++ +T   T E  
Sbjct: 417  PIPFSLPEGL-PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475

Query: 1816 PIWRP--GTEQSSGSSGSSGGGGGSS-SRPASHSHAHQHSPISPRTQDALQQRPSVLHNT 1872
               +   G E+  G    + GG   + S PA  + + +    SP  ++A  + P+   + 
Sbjct: 476  KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSP 533

Query: 1873 GMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKE 1932
              +   +  E  +P         SP +  A  PP    P             E    P E
Sbjct: 534  EKEEAKSPAEVKSPE-----KAKSPAKEEAKSPPEAKSPE-----------KEEAKSPAE 577

Query: 1933 APRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKN 1992
               V  PE+          AK PA+   E A SP++   P     PV      A++PA+ 
Sbjct: 578  ---VKSPEK----------AKSPAK---EEAKSPAEAKSPEKAKSPVKEE---AKSPAEA 618

Query: 1993 LAPHHASPDPPA---PPASASDPHREKTQS--KPFSIQELELRSLGYHGSSYSPEGVEP- 2046
             +P       PA    P  A  P +E+ +S  K  S ++ E +S     S    E   P 
Sbjct: 619  KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678

Query: 2047 --VSPVSSPSLTHDKGLPKHLEELD-----KSHLEGELR--PKQPGPVKLGGEAAHLPHL 2097
               SPV + + + +K      EE       KS ++ E +   K   PVK   E A  P  
Sbjct: 679  KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK---EEAKTPEK 735

Query: 2098 RPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSF 2157
               P  + + SP    +P     ++  TL     E  T       P +  A  PA    F
Sbjct: 736  AKSPVKEEAKSPEKAKSP-----EKAKTLDVKSPEAKT-------PAKEEARSPAD--KF 781

Query: 2158 P-GASCPVLDLRRPPSDLYLP-PPDHGAPARGSPHSE----GGKRSPEPNKTSVLGGGED 2211
            P  A  PV +  + P     P   D  AP +  P  E      K   +P +  V    + 
Sbjct: 782  PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841

Query: 2212 GIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTE-PSRMGSKSPGNTSQPPAFFSKLTESN 2270
              E  +P    TE             +D ++ E P +   K      + PA    + +  
Sbjct: 842  AEEEKAPATPKTEE-----------KKDSKKEEAPKKEAPKPKVEEKKEPA----VEKPK 886

Query: 2271 SAMVKSKKQEI--NKKLNTHNRNEP 2293
             + V++KK+E    KK+ T  +  P
Sbjct: 887  ESKVEAKKEEAEDKKKVPTPEKEAP 911



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 62/265 (23%), Positives = 112/265 (42%), Gaps = 17/265 (6%)

Query: 93  PELGKSEMEFIESKRPRLELLPDPLLRPSPLLATG-QPAGSEDLTKDRSLT-GKLEPVSP 150
           PE  KS ++  E+K P     P      SP  A   + A + D+    + T  K E  SP
Sbjct: 719 PEKAKSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777

Query: 151 ----PSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAK 206
               P    +  + E+  P  +K  L ++    ++EI   E+  S +K++++  E +  +
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837

Query: 207 PP---EPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDT 263
           PP   E EK  + P  E K  S      +E  KK     ++ E   P VE P  ++    
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSK----KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893

Query: 264 RQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWE--KKVERIENNPR 321
           ++  E+ K      K+     + +  A+ + + +  ++     +A E  K  E+ E  P 
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953

Query: 322 RR-AKESKVREYYEKQFPEIRKQRE 345
           ++  KE K ++  EK   E + + +
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKED 978



 Score = 33.9 bits (76), Expect = 2.0
 Identities = 43/206 (20%), Positives = 83/206 (40%), Gaps = 14/206 (6%)

Query: 54  SPGSIIQPQRRRPSLLSEFQ-PGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLEL 112
           SP  +  P++ +     E + P   +S E     ++ S + E  KS  E   +K P  E 
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPE-----KAKSPVKEEAKSPAE---AKSPVKEE 625

Query: 113 LPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEEL 172
              P    SP  A   P   E  + +++ + + E    P    +  + E   P  +K  +
Sbjct: 626 AKSPAEVKSPEKAKS-PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684

Query: 173 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV---SPPPIESKHRSLVQI 229
                  ++  + V+++    +K +  ++EEA  P + + PV   +  P ++K     + 
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744

Query: 230 IYDENRKKAEAAHRILEGLGPQVELP 255
              E  K  E A + L+   P+ + P
Sbjct: 745 KSPEKAKSPEKA-KTLDVKSPEAKTP 769


>gi|209977084 REST corepressor 3 isoform c [Homo sapiens]
          Length = 449

 Score =  100 bits (250), Expect = 1e-20
 Identities = 86/311 (27%), Positives = 136/311 (43%), Gaps = 41/311 (13%)

Query: 432 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRG 491
           W+ ++K  F + F  H K+F  I   L  KT+A  V YYY  KK  +  SL+ R  R   
Sbjct: 147 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQAR--- 203

Query: 492 KSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL------ 545
           K   +  Q       ++  PM  +  +   +KE +KE   E+    V+  K  L      
Sbjct: 204 KLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQP---VQTSKIGLGRREYQ 260

Query: 546 --------LKEKTDDTSGEDNDEKEAVA-SKGRKTANSQGRRKGR----ITRSMANEANS 592
                    + K     G    +++ VA S     AN+  R+       + R + N    
Sbjct: 261 SLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQV 320

Query: 593 EEAITPQQSAELASMELNESS-----RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVS 647
             A+  +    +   +  ES+     RWT EE   A +G+ ++G+++ AIA ++G+KTV 
Sbjct: 321 NSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVG 380

Query: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707
           Q KNF+ NY++R NL+E+LQ+     E E+  +     A     E  +   V        
Sbjct: 381 QVKNFFVNYRRRFNLEEVLQE----WEAEQGTQASNGDASTLGEETKSASNV-------P 429

Query: 708 SGVSGNEEEMV 718
           SG S +EEE V
Sbjct: 430 SGKSTDEEEEV 440


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  100 bits (250), Expect = 1e-20
 Identities = 193/820 (23%), Positives = 279/820 (34%), Gaps = 154/820 (18%)

Query: 432  WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489
            W+E E + F +   Q+ KNF  I    L  K   E + +YY  KK  E   S   R +RR
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455

Query: 490  RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530
            +   ++ + +          +P       +  +S+++ D ++ E+E +            
Sbjct: 456  QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515

Query: 531  ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562
                                  K  E P +E   +        +KE+ D  SG+ +    
Sbjct: 516  KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575

Query: 563  AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621
               S+G  +    GR+K   +     +  N +   + + S   AS   N+S      + E
Sbjct: 576  R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627

Query: 622  TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681
            T KK            A+ V  +  S  K+      KRQ       + K+  + E   R 
Sbjct: 628  TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664

Query: 682  KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPH-TE 740
              KK           P   E E  ++  V  N+E   +  +   +N S + SIPSP   E
Sbjct: 665  SSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDIDQDNRSTSPSIPSPQDNE 722

Query: 741  AAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE-PTPASEAT---GAPTPP 792
            +  D+         +PPA     G  P P + PP     PT  PTP++ A    G+PT  
Sbjct: 723  SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS 782

Query: 793  PAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850
             AP  P AP   VP    ++  A  P  P        P     L   TG A +P      
Sbjct: 783  QAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP----SA 838

Query: 851  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910
                + P  G+      +   G L               +  G PQ        S     
Sbjct: 839  PSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPGPPQPFGLPPQASQ---G 881

Query: 911  EAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970
            +A  G       P  SL  P     A  S Q P        R   +PP  +   H  P  
Sbjct: 882  QAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------REQPLPPAPLAMPHIKP-- 930

Query: 971  DAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEA 1030
               PT P P  P P  +  P    P   G SP   + +  PP    A KP+   +     
Sbjct: 931  --PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP---PALKPLSSLSTHHPP 981

Query: 1031 QKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPPGHPLPLGLHDTA-RPVL 1087
               P          P P  P +   +  S + P P      P  HP P GLH  A +P  
Sbjct: 982  SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PASHP-PTGLHQVAPQPPF 1034

Query: 1088 PRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG--LPL 1145
             + P +   PP I+    PS      G    G S Q   P    A A  G +  G   PL
Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCSGAAASGGSIAGGSSCPL 1088

Query: 1146 P-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184
            P +  K+ A     + E   P  ++  PE   V T   AS
Sbjct: 1089 PTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 1128



 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 163/733 (22%), Positives = 260/733 (35%), Gaps = 167/733 (22%)

Query: 615  WTEEEMETAKKGLLEHGRNWSAIAR-MVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKM 673
            WTE+E++   KGL ++G+N+  I + ++ +K   +   FY+ +KK    +    +   + 
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTP--EAASSRAHRRH 453

Query: 674  EKERNARRKKKKAPAAASEEAAFPPV---------------VEDEEMEASGVS------- 711
             ++   RR K +  +      + PP                 ED E E  G +       
Sbjct: 454  RRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTT 513

Query: 712  -------GNEEEMVEEAEATVNNSSDTESIP------------SPHTEAAKDTGQNGPKP 752
                   G  E ++   +  ++     E  P             P  E  +D G +G   
Sbjct: 514  TSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKE--EDDGLSGKHS 571

Query: 753  PATLGADG--------------PPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSP 798
              T  + G               P G  +P  EDI +    +P++ +T          S 
Sbjct: 572  MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTS---------SN 622

Query: 799  SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE---- 854
             +    V K  K+ +  A+ P++  + Q+    E++A DT +A+    S+ T+  E    
Sbjct: 623  DSKAETVKKSAKKVKEEASSPLKSNKRQR----EKVASDTEEADR-TSSKKTKTQEISRP 677

Query: 855  EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914
              P++G+   +   +      ++ K+      +T+ S  +PQD++S +  SA +      
Sbjct: 678  NSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ------ 731

Query: 915  GDKNRLLSPRPSLLTPTGDPRA--NASPQKP-LDLKQLKQRAAAIPPIQVTKVHEPPRED 971
                 L +  P+L  PTG   A  +A P  P L        A A+PP       + P + 
Sbjct: 732  ---QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788

Query: 972  AAPTKPA---------------PPAPPPPQNLQPESDAPQQPGSSPRGKSRSPA------ 1010
             APT P                PP+P PP +  P    P QP +   G+  +P+      
Sbjct: 789  QAPTAPVPHTHIQQAPALHPQRPPSPHPPPH--PSPHPPLQPLTGSAGQPSAPSHAQPPL 846

Query: 1011 ----PPADKEAE-----------KPVFFPAFAAEAQKLPGDPPCWT------------SG 1043
                PP     +           +P   P  A++ Q   G  P               S 
Sbjct: 847  HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSA 906

Query: 1044 LPFPVPPREVIKASPHAPDPSAFSY--APPGHPLPLGLHDTARPVLPRPPTISNPPPLIS 1101
            L    PPRE     P  P P A  +   PP  P+P      A      PP +S P P   
Sbjct: 907  LQSQQPPRE----QPLPPAPLAMPHIKPPPTTPIP---QLPAPQAHKHPPHLSGPSPFSM 959

Query: 1102 SAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQE 1161
            +A  P        A+    S+  H P S H   P+  +    PLP  P +  P    + +
Sbjct: 960  NANLPPP-----PALKPLSSLSTHHPPSAH-PPPLQLMPQSQPLPSSPAQ--PPGLTQSQ 1011

Query: 1162 QLSPRGQAGPPESL-----GVPTAQEASVLRGTALGSVPGGSITKGIP-----STRVPSD 1211
             L P   + PP  L       P AQ   V  G    + P    T   P     S + P  
Sbjct: 1012 NLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCS 1071

Query: 1212 SAITYRGSITHGT 1224
             A    GSI  G+
Sbjct: 1072 GAAASGGSIAGGS 1084



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223

Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281

Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338

Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385

Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437

Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492

Query: 2137 D-YTRHHPQQLSAPLPAPL 2154
              +   +P+ L   +P P+
Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692

Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 693  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741

Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 742  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800

Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860

Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 861  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920

Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979

Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 980  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028

Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056

Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111

Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156

Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214

Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274

Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334

Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394

Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454

Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173
                L+A      + +P  + P   L +PP +
Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486



 Score = 39.7 bits (91), Expect = 0.037
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 630  KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683

Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 684  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728

Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 729  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779

Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 780  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893

Query: 2253 PGNTSQPPAFFSKL 2266
            P  + Q PA  S L
Sbjct: 894  PHTSLQLPASQSAL 907



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%)

Query: 670  KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729
            KL  ++E    + K++A   A EE        ++E E       E E   E  A  ++S+
Sbjct: 1158 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 1212

Query: 730  DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784
                +  P          +   PP T+ A  P  GP TP    +     P    PT  + 
Sbjct: 1213 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 1272

Query: 785  ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829
                P  P  P      P      P + + E  E       + E         G E KPP
Sbjct: 1273 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 1332

Query: 830  AAEEL 834
              + L
Sbjct: 1333 ELDPL 1337



 Score = 33.9 bits (76), Expect = 2.0
 Identities = 12/24 (50%), Positives = 19/24 (79%)

Query: 1780 TTTSSSERERDRDRERDRDREREK 1803
            T     ++++++DR+RDRDREREK
Sbjct: 2    TADKDKDKDKEKDRDRDRDREREK 25



 Score = 32.0 bits (71), Expect = 7.7
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
            G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  100 bits (250), Expect = 1e-20
 Identities = 193/820 (23%), Positives = 279/820 (34%), Gaps = 154/820 (18%)

Query: 432  WSEQEKETFREKFMQHPKNFGLIAS-FLERKTVAECVLYYYLTKKN-ENYKSLVRRSYRR 489
            W+E E + F +   Q+ KNF  I    L  K   E + +YY  KK  E   S   R +RR
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRR 455

Query: 490  RGKSQQQQQQQQQQQQQQQQQP-------MPRSSQEEKDEKEKEKEAE------------ 530
            +   ++ + +          +P       +  +S+++ D ++ E+E +            
Sbjct: 456  QAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTS 515

Query: 531  ----------------------KEEEKPEVENDKEDL------LKEKTDDTSGEDNDEKE 562
                                  K  E P +E   +        +KE+ D  SG+ +    
Sbjct: 516  KDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTR 575

Query: 563  AVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAELASMELNESSRWTEEEME 621
               S+G  +    GR+K   +     +  N +   + + S   AS   N+S      + E
Sbjct: 576  R--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS------KAE 627

Query: 622  TAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARR 681
            T KK            A+ V  +  S  K+      KRQ       + K+  + E   R 
Sbjct: 628  TVKKS-----------AKKVKEEASSPLKS-----NKRQ-------REKVASDTEEADRT 664

Query: 682  KKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPH-TE 740
              KK           P   E E  ++  V  N+E   +  +   +N S + SIPSP   E
Sbjct: 665  SSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDIDQDNRSTSPSIPSPQDNE 722

Query: 741  AAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE-PTPASEAT---GAPTPP 792
            +  D+         +PPA     G  P P + PP     PT  PTP++ A    G+PT  
Sbjct: 723  SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAS 782

Query: 793  PAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850
             AP  P AP   VP    ++  A  P  P        P     L   TG A +P      
Sbjct: 783  QAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP----SA 838

Query: 851  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910
                + P  G+      +   G L               +  G PQ        S     
Sbjct: 839  PSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPGPPQPFGLPPQASQ---G 881

Query: 911  EAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970
            +A  G       P  SL  P     A  S Q P        R   +PP  +   H  P  
Sbjct: 882  QAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------REQPLPPAPLAMPHIKP-- 930

Query: 971  DAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEA 1030
               PT P P  P P  +  P    P   G SP   + +  PP    A KP+   +     
Sbjct: 931  --PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP---PALKPLSSLSTHHPP 981

Query: 1031 QKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPPGHPLPLGLHDTA-RPVL 1087
               P          P P  P +   +  S + P P      P  HP P GLH  A +P  
Sbjct: 982  SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PASHP-PTGLHQVAPQPPF 1034

Query: 1088 PRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMG--LPL 1145
             + P +   PP I+    PS      G    G S Q   P    A A  G +  G   PL
Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCSGAAASGGSIAGGSSCPL 1088

Query: 1146 P-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184
            P +  K+ A     + E   P  ++  PE   V T   AS
Sbjct: 1089 PTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 1128



 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 163/733 (22%), Positives = 260/733 (35%), Gaps = 167/733 (22%)

Query: 615  WTEEEMETAKKGLLEHGRNWSAIAR-MVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKM 673
            WTE+E++   KGL ++G+N+  I + ++ +K   +   FY+ +KK    +    +   + 
Sbjct: 396  WTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTP--EAASSRAHRRH 453

Query: 674  EKERNARRKKKKAPAAASEEAAFPPV---------------VEDEEMEASGVS------- 711
             ++   RR K +  +      + PP                 ED E E  G +       
Sbjct: 454  RRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTT 513

Query: 712  -------GNEEEMVEEAEATVNNSSDTESIP------------SPHTEAAKDTGQNGPKP 752
                   G  E ++   +  ++     E  P             P  E  +D G +G   
Sbjct: 514  TSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKE--EDDGLSGKHS 571

Query: 753  PATLGADG--------------PPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSP 798
              T  + G               P G  +P  EDI +    +P++ +T          S 
Sbjct: 572  MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTS---------SN 622

Query: 799  SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE---- 854
             +    V K  K+ +  A+ P++  + Q+    E++A DT +A+    S+ T+  E    
Sbjct: 623  DSKAETVKKSAKKVKEEASSPLKSNKRQR----EKVASDTEEADR-TSSKKTKTQEISRP 677

Query: 855  EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914
              P++G+   +   +      ++ K+      +T+ S  +PQD++S +  SA +      
Sbjct: 678  NSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ------ 731

Query: 915  GDKNRLLSPRPSLLTPTGDPRA--NASPQKP-LDLKQLKQRAAAIPPIQVTKVHEPPRED 971
                 L +  P+L  PTG   A  +A P  P L        A A+PP       + P + 
Sbjct: 732  ---QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788

Query: 972  AAPTKPA---------------PPAPPPPQNLQPESDAPQQPGSSPRGKSRSPA------ 1010
             APT P                PP+P PP +  P    P QP +   G+  +P+      
Sbjct: 789  QAPTAPVPHTHIQQAPALHPQRPPSPHPPPH--PSPHPPLQPLTGSAGQPSAPSHAQPPL 846

Query: 1011 ----PPADKEAE-----------KPVFFPAFAAEAQKLPGDPPCWT------------SG 1043
                PP     +           +P   P  A++ Q   G  P               S 
Sbjct: 847  HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSA 906

Query: 1044 LPFPVPPREVIKASPHAPDPSAFSY--APPGHPLPLGLHDTARPVLPRPPTISNPPPLIS 1101
            L    PPRE     P  P P A  +   PP  P+P      A      PP +S P P   
Sbjct: 907  LQSQQPPRE----QPLPPAPLAMPHIKPPPTTPIP---QLPAPQAHKHPPHLSGPSPFSM 959

Query: 1102 SAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQE 1161
            +A  P        A+    S+  H P S H   P+  +    PLP  P +  P    + +
Sbjct: 960  NANLPPP-----PALKPLSSLSTHHPPSAH-PPPLQLMPQSQPLPSSPAQ--PPGLTQSQ 1011

Query: 1162 QLSPRGQAGPPESL-----GVPTAQEASVLRGTALGSVPGGSITKGIP-----STRVPSD 1211
             L P   + PP  L       P AQ   V  G    + P    T   P     S + P  
Sbjct: 1012 NLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCS 1071

Query: 1212 SAITYRGSITHGT 1224
             A    GSI  G+
Sbjct: 1072 GAAASGGSIAGGS 1084



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 1181 EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 1223

Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 1224 GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 1281

Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 1282 DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 1338

Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 1339 PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 1385

Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 1386 LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 1437

Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 1438 LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 1492

Query: 2137 D-YTRHHPQQLSAPLPAPL 2154
              +   +P+ L   +P P+
Sbjct: 1493 PVFGTPYPRDLPGAIPPPM 1511



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 637  KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 692

Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 693  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 741

Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 742  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 800

Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 801  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 860

Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 861  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 920

Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 921  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 979

Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 980  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 1028

Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 1029 A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 1056

Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 1057 -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 1111

Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 1112 RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 1156

Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 1157 SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 1214

Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 1215 GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 1274

Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 1275 YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 1334

Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 1335 DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 1394

Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 1395 RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 1454

Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173
                L+A      + +P  + P   L +PP +
Sbjct: 1455 LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486



 Score = 39.7 bits (91), Expect = 0.037
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 630  KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 683

Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 684  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 728

Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 729  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 779

Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 780  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893

Query: 2253 PGNTSQPPAFFSKL 2266
            P  + Q PA  S L
Sbjct: 894  PHTSLQLPASQSAL 907



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%)

Query: 670  KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729
            KL  ++E    + K++A   A EE        ++E E       E E   E  A  ++S+
Sbjct: 1158 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 1212

Query: 730  DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784
                +  P          +   PP T+ A  P  GP TP    +     P    PT  + 
Sbjct: 1213 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 1272

Query: 785  ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829
                P  P  P      P      P + + E  E       + E         G E KPP
Sbjct: 1273 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 1332

Query: 830  AAEEL 834
              + L
Sbjct: 1333 ELDPL 1337



 Score = 33.9 bits (76), Expect = 2.0
 Identities = 12/24 (50%), Positives = 19/24 (79%)

Query: 1780 TTTSSSERERDRDRERDRDREREK 1803
            T     ++++++DR+RDRDREREK
Sbjct: 2    TADKDKDKDKEKDRDRDRDREREK 25



 Score = 32.0 bits (71), Expect = 7.7
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
            G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 1156 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 1200


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 285/1292 (22%), Positives = 414/1292 (32%), Gaps = 243/1292 (18%)

Query: 721  AEATVNNSSDTESIPSPHTEAAKDTG-QNGPKPPATLGADGPPPGPPTPPPEDIPAPTEP 779
            A  T   +S   +  SP  E       +N P    TL         P  P      P  P
Sbjct: 659  APTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTT------LPLVPTASENCPVAP 712

Query: 780  TPASEATG------APTPPPAPPSPSAPPPVVPKEEKE----EETAAAPPVEEGEEQKP- 828
            +P +          AP  P + PSPS PP   P   K+      T+A  PV    ++ P 
Sbjct: 713  SPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPT 772

Query: 829  ------PAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGG 882
                    A      T  A+ P     +   +      K   A   T  G L        
Sbjct: 773  EDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL-------- 824

Query: 883  SGRATTAKSSGAPQDS-------DSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR 935
            S   +  ++S  P++S       DS AT  +      +G       +P PS +TP     
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKG-------APTPSAVTPLSPKG 877

Query: 936  ANASPQKP-----LDLKQLKQRAAAIPPIQV----------TKVHEPPREDAAPTKPAPP 980
                P++      ++L   K+  A   P Q            K    P     P  P+P 
Sbjct: 878  VTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPK 937

Query: 981  APPPPQNLQPESD-----------APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF--- 1026
              P P    P S            AP  P ++P      PA P+ K A  P   PA    
Sbjct: 938  GAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPP 994

Query: 1027 ------AAEAQKLPGDPPCWTSGLPFPVP---PREVIKASPHAPDPSAFSYAPPGHPLPL 1077
                  A  + K    PP  T   P   P   P     ++P A  P +   +P   PLP 
Sbjct: 995  SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054

Query: 1078 GLHDTARPVLPRPPTISNPPPLISSAKHPSVL-ERQIGAISQGMSVQLHVPYSEHAKAPV 1136
            G   T    LP P      P L  +   P+       G  +        +P +    +P 
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK 1114

Query: 1137 GPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPG 1196
            G    GL  P  P K AP +       SP+G    P   G PT   A+        S  G
Sbjct: 1115 G----GLATP--PHKGAPTTPAATPP-SPKGGLATPPPKGAPTTPAATP------PSPKG 1161

Query: 1197 GSIT---KGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDS 1253
            G  T   KG P+T  P+ +  + +G +   +P     KG  T       PS         
Sbjct: 1162 GLATPPPKGAPTT--PAATPPSPKGGLATPSP-----KGAPT-TPAATPPS--------- 1204

Query: 1254 LPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAI 1313
             PKG +     KG   +     + T  S + G ++  P      P  T    +G      
Sbjct: 1205 -PKGGLATPSPKGAPTT----PAATPPSPKGGLATPSPKGAPTTPAATPPSPKG------ 1253

Query: 1314 SSASIEGLMGRAIPPERHSP-HHLKEQHHIRGSIT----QGIPRSYVEAQEDYLRREAKL 1368
                     G A PP + +P         ++G +     +G P   V             
Sbjct: 1254 ---------GPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAV------------- 1291

Query: 1369 LKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGR-SIHEIPREELRHT 1427
                   PP P     T   K     P    P+ +G   T    G  +   +     + T
Sbjct: 1292 -----VTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGT 1346

Query: 1428 PELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGR-----------TFP 1476
            P LP A  P  +G  T  +  +  T  + T S K        SP R           T P
Sbjct: 1347 PTLP-ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSP 1405

Query: 1477 PVHPLD-VMADARALER--------------ACYEESLKSRPGTASSSGGSI---ARGAP 1518
             V PL    A A  + R              A    SLK  P T++  GG     ++G P
Sbjct: 1406 AVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDP 1465

Query: 1519 VI----------------VPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTRE----PTP 1558
             +                V     P+++P T    GAP    LP   P + +E    P+ 
Sbjct: 1466 TLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAP---TLPAVIPSSPKEVPATPSS 1522

Query: 1559 RLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSH 1618
            R    + +++  S+    T  P+E    P  TVP     P  P        +      + 
Sbjct: 1523 RRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK--EAPATPSSKEAS 1580

Query: 1619 IPLAFDPTSI-----PRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENR 1673
             P A  P++      P+ + +  A     P+     PT P + PP   +G P T A +  
Sbjct: 1581 SPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEA---PTPPAVTPPSPEKG-PATPAPKGT 1636

Query: 1674 QTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVP---H 1730
             T  +  +T   +  +  +  +    M  G +  ++S  L    GP  + ++   P    
Sbjct: 1637 PT--SPPVTPSSLKDSPTSPASVTCKM--GATVPQASKGLPAKKGPTALKEVLVAPAPES 1692

Query: 1731 LPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERD 1790
             P++  PT   P T        P  P P +   S  PLS   P  L  P    SS+  + 
Sbjct: 1693 TPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLL-PVQKDSSKTAKG 1751

Query: 1791 RDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQ 1850
            +D          K  L    +    P+     E+       S     + S P S   A  
Sbjct: 1752 KDASHS-----PKGPLAPPESKASTPLTAAAFEKVL-PKPESASVSAAPSPPVSLPLAPS 1805

Query: 1851 HSPISPRTQDALQQRPSVLHNTGMKGIITAVE 1882
              P  P  Q  L   P ++  +  K +  A E
Sbjct: 1806 PVPTLPPKQQFLPSSPGLVLESPSKPLAPADE 1837



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 212/937 (22%), Positives = 303/937 (32%), Gaps = 195/937 (20%)

Query: 750  PKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA-PPSPSAPPPVVPKE 808
            P P  +  A   P G PT P   +P+P          GAPTPP A PPSP   P     +
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100

Query: 809  EKEEETAAAPPVEEGEEQKP--------PAAEELAVDTGKAEEPVKSECTEEAEEGPA-K 859
                  AA PP  +G    P        PAA   +   G A  P K   T  A   P+ K
Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 860  G-------KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEA 912
            G       K A    A    + K          A T  ++  P      AT S       
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 913  EG----GDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHE 966
                    K  L +P P  +  TP   P +          K      AA PP     +  
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT 1280

Query: 967  PPREDAA-PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
            PP + A  P    PP+P       P   AP  P ++P     SP  P  K A  P   PA
Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTP---PA 1337

Query: 1026 FAAEAQK----LPG------------------DPPCWT---SGLPFPVPPREVIKASPHA 1060
                + K    LP                    PP  T    G P   PP    K  P  
Sbjct: 1338 VTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSP--KRGPAI 1395

Query: 1061 PDPSAFSYAPPGHPL--------PLGLHDTARP-------------VLPRPPTISNP--- 1096
            P P     +P   PL        P+     A P              L + P  S P   
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455

Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLP-----LPMDPKK 1151
            P   SS   P++      +  +  + +     S   KAP  P  MG P     +P  PK+
Sbjct: 1456 PATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKE 1515

Query: 1152 LAPFSGVKQEQLSPR---------GQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKG 1202
            +      +++ ++P              P E+L +P A      + T   ++P       
Sbjct: 1516 VPATPSSRRDPIAPTATLLSKKTPATLAPKEAL-IPPAMTVPSPKKTP--AIPTPKEAPA 1572

Query: 1203 IPSTR----VPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGH 1258
             PS++     P+ +  TY+G+    +P ++L    +T    +++P+              
Sbjct: 1573 TPSSKEASSPPAVTPSTYKGA---PSPKELLIPPAVTSPSPKEAPT-------------- 1615

Query: 1259 VIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASI 1318
                             +VT  S E G ++  P     +P  T   ++       S AS+
Sbjct: 1616 ---------------PPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLK---DSPTSPASV 1657

Query: 1319 EGLMGRAIP------PERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKRE 1372
               MG  +P      P +  P  LKE       +    P S         R+  +  K  
Sbjct: 1658 TCKMGATVPQASKGLPAKKGPTALKE------VLVAPAPES-TPIITAPTRKGPQTKKSS 1710

Query: 1373 GTPPP--PPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPEL 1430
             T PP  P PS           + P  L P  +    T K           ++  H+P+ 
Sbjct: 1711 ATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAK----------GKDASHSPKG 1760

Query: 1431 PLAP------RPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVM 1484
            PLAP       PL   +  +  P       S   S    +  L  SP  T PP       
Sbjct: 1761 PLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSL-PLAPSPVPTLPP------- 1812

Query: 1485 ADARALERACYEESLKSRPGTASSSGGSIARGA------PVIVPEL---GKPRQSPLTYE 1535
                       ++ L S PG    S       A      P+I PE    G P QS L   
Sbjct: 1813 ----------KQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLV-- 1860

Query: 1536 DHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSSKASQ 1572
            +   P +  +P  +P + ++P  +  +GS + S + +
Sbjct: 1861 NMPTPKSAGIPVPTP-SAKQPVTKNNKGSGTESDSDE 1896



 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 100/408 (24%), Positives = 146/408 (35%), Gaps = 65/408 (15%)

Query: 684  KKAPAAASEEAA--FPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTE--------- 732
            KKAPA  +   A   P V+     E      +  + +      ++  +            
Sbjct: 1491 KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIP 1550

Query: 733  ---SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT-----PPPEDI---PAPTEPTP 781
               ++PSP    A  T +  P  P++  A  PP   P+     P P+++   PA T P+P
Sbjct: 1551 PAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSP 1610

Query: 782  ASEATGAPTPPP-APPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840
                  APTPP   PPSP   P              A P  +G    PP       D+  
Sbjct: 1611 KE----APTPPAVTPPSPEKGP--------------ATPAPKGTPTSPPVTPSSLKDSPT 1652

Query: 841  AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900
            +   V  +      +  +KG  A+      +  L A   E  S    TA +   PQ   S
Sbjct: 1653 SPASVTCKMGATVPQA-SKGLPAKKGPTALKEVLVAPAPE--STPIITAPTRKGPQTKKS 1709

Query: 901  SATCSADEVD-EAEGGDKNRLLSPRPSLLTPTGDPR--------ANASPQKPLDLKQLKQ 951
            SAT      D  A+ G K  L +  P+ L P             A+ SP+ PL   + K 
Sbjct: 1710 SATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESK- 1768

Query: 952  RAAAIPPIQVTKVHEPPREDAAPTKPAPP-----APPPPQNLQPESD-APQQPGSSPRGK 1005
             +  +      KV   P   +    P+PP     AP P   L P+    P  PG      
Sbjct: 1769 ASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESP 1828

Query: 1006 SRSPAPPADKEAEKPVFFPAFAAEA----QKLPGDPPCWTSGLPFPVP 1049
            S+ P  PAD++   P+  P   +        L   P   ++G+P P P
Sbjct: 1829 SK-PLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTP 1875



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 374/1670 (22%), Positives = 528/1670 (31%), Gaps = 307/1670 (18%)

Query: 728  SSDTESIPSPHTEAAKDTGQNGPKP-PATLGADGPPPGPPTPPPEDIPAPTEPTPASEAT 786
            S  T+S+P   T + K  G N P   P +LG+   P    +     +   T P+  S+ T
Sbjct: 277  SLSTQSLPVV-TSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPT 335

Query: 787  -------GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA--------- 830
                    + T    P   S  PP+  + E    T AA PV      K P+         
Sbjct: 336  VKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSP 395

Query: 831  AEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 890
            +  L V T  +  P  S   + +              AT    L A+      G      
Sbjct: 396  SGSLNVATSFSLSPTTSLILKSSPN------------ATYHYPLVAQMPVSSVGTTPLVV 443

Query: 891  SS-----GAPQDSDSSATC-----SADEVDEAEGGDKNRLL-------SPRPSLLTPTGD 933
            ++      AP  +   ATC     S+  +   E      L+        P   + T    
Sbjct: 444  TNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRI 503

Query: 934  PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993
            P +   P  P DLK L        P Q      P   + AP  PA       ++      
Sbjct: 504  PVSPPLPD-PEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPL 562

Query: 994  APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREV 1053
                P +SP  +S S +P      E        A  A+K  G+P      LP   P   +
Sbjct: 563  VQAAPKNSPSFQSTSSSPEIPLSPE--------ATLAKKSLGEP------LPIGKPASSM 608

Query: 1054 IKASPHAPDPSAF-----SYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLIS--SAKHP 1106
               SP   + SA      SYA P    PL       P +   P  S  P  ++  +AK  
Sbjct: 609  --TSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGT 666

Query: 1107 SVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR 1166
            S          +G +V L  P +   K   G +T  LPL     +  P +   Q   +P 
Sbjct: 667  STYTTTASPFLEG-TVSL-APKNHPVKE--GTLTT-LPLVPTASENCPVAPSPQNTCAPL 721

Query: 1167 GQA--GP--PESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITH 1222
                  P  P+S+  P+   A        G+ PG     GI  T   +  A + +   T 
Sbjct: 722  ATLVLAPEIPKSVPSPSLPPA--------GTPPGTKKVDGISHTSALAPVASSPKECPTE 773

Query: 1223 --GTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQC 1280
              G  A    KGT+T +   DSPS L                           G+SV+  
Sbjct: 774  DSGASATASSKGTLTYLA--DSPSPL---------------------------GVSVSPQ 804

Query: 1281 SKEDG--RSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKE 1338
            +K     + S+GP             +E       +S S +G   +  P   HSP     
Sbjct: 805  TKRPPTKKGSAGPDTPIGNLSSPVSPVEASF-LPENSLSFQG--SKDSPATTHSPTPPSP 861

Query: 1339 QHHIRGS-ITQGIPRSYVEAQEDYLRREAKLLK--REGTPPPPP---PSRDLTEAYKTQA 1392
            +     S +T   P+      ++        L   +EG   P P   P+  +T +   +A
Sbjct: 862  KGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKA 921

Query: 1393 LGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDT 1452
                +  PA +G+ A+    G             TP     P P K G  T         
Sbjct: 922  ----RATPAPKGIPASPSPKGAP-----------TPPAATPPSP-KGGPATPSPKWAPTP 965

Query: 1453 GASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLKSRPGTASSSGGS 1512
             A+T  S K       G P    P   P    A            S K  P T S  G  
Sbjct: 966  PAATPPSPK-------GGPATPSPKGAPTPPAATP---------PSPKGGPATPSPKG-- 1007

Query: 1513 IARGAPVIVPEL--GKPRQSPLTY-----------EDHGAPFAGHLPRGSPVTTREPTPR 1559
             A   P + P    G P  +P                 G+P A  LP+G+P T     P 
Sbjct: 1008 -APTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066

Query: 1560 LQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRS-- 1617
             + G  + S         +TP      P +  P+  P P +      +G      ++   
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126

Query: 1618 HIPLAFDP-------TSIPRGIPLDAAAAYYLPR-HLAP-----NPTYPHLYPPYLIRGY 1664
              P A  P       T  P+G P   AA    P+  LA       PT P   PP    G 
Sbjct: 1127 TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG- 1185

Query: 1665 PDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIID 1724
               A    +        T        AT   + A      +P      L     P+G   
Sbjct: 1186 --LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGL-ATPSPKG--- 1239

Query: 1725 LSQVPHLPVLVPPTP-GTPATAMDRLAYLPTAPQPFSSR-------HSS-------SPLS 1769
                P  P   PP+P G PAT   + A  P A  P S +       H         +P S
Sbjct: 1240 ---APTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296

Query: 1770 PGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSS 1829
            P G    + P    +         +        K   T       +P    GT     ++
Sbjct: 1297 PKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP---KGTPTLPATT 1353

Query: 1830 GSSGGGGGSSSR------PA---SHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITA 1880
             SS GG  + S       PA   SH      +P SP+   A+        +  +  +   
Sbjct: 1354 PSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413

Query: 1881 VEPSTPTVLRSTSTSS--PVRPAATFP------PATHCPLGGTL------DGVYPTLMEP 1926
              P+TP      +T S   + P A  P      PAT  P GG        D   P +  P
Sbjct: 1414 KAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPP 1473

Query: 1927 VLLPKEAP---RVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHA 1983
               PKE P   +VA    P+           P    + P+S     + P     P++  A
Sbjct: 1474 --SPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTA 1531

Query: 1984 TI--ARTPAKNLAPHHA-------------SPDPPAPPASASDPHREKTQSKPF------ 2022
            T+   +TPA  LAP  A             +P  P P  + + P  ++  S P       
Sbjct: 1532 TLLSKKTPA-TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590

Query: 2023 ----SIQELELRSLGYHGS---SYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075
                S +EL +       S   + +P  V P SP   P+    KG P        S  + 
Sbjct: 1591 KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDS 1650

Query: 2076 ELRP--------------KQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQ 2121
               P               +  P K G  A     + P PES P     + TAP  KG Q
Sbjct: 1651 PTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTP-----IITAPTRKGPQ 1705

Query: 2122 RVVTLAQHISEVITQDYTRHHPQQ--LSAPLPAPLYSFPGASCPVL---DLRRPPSDLYL 2176
               + A   S  I  D +  +  +  LS   PAPL      S       D    P     
Sbjct: 1706 TKKSSA--TSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLA 1763

Query: 2177 PPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE-PVSPPEGMTEP 2225
            PP    +    +   E  K  P+P   SV       +  P++P    T P
Sbjct: 1764 PPESKASTPLTAAAFE--KVLPKPESASVSAAPSPPVSLPLAPSPVPTLP 1811



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 133/567 (23%), Positives = 179/567 (31%), Gaps = 120/567 (21%)

Query: 1717 AGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSS--PLSPGGPT 1774
            + P   ++ S +P   +    +  +PAT      + PT P P  +   S+  PLSP G T
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATT-----HSPTPPSPKGAPTPSAVTPLSPKGVT 879

Query: 1775 HLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGG 1834
               K T T S                           V + P  + G    +     +  
Sbjct: 880  LPPKETPTPS---------------------------VVNLPFPKEGPATPAPKQAPALS 912

Query: 1835 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTST 1894
               SS + A  + A +  P SP  + A    P        KG      P+TP+       
Sbjct: 913  MTSSSPKKARATPAPKGIPASPSPKGA--PTPPAATPPSPKG-----GPATPS-----PK 960

Query: 1895 SSPVRPAATFP-----PATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHA 1949
             +P  PAAT P     PAT  P G       P    P   PK  P  A P    A T  A
Sbjct: 961  WAPTPPAATPPSPKGGPATPSPKGAPTP---PAATPPS--PKGGP--ATPSPKGAPTPPA 1013

Query: 1950 FLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASA 2009
                PP+  G   A+   KG+   P   P S   + A TP    AP   +   P+P    
Sbjct: 1014 --VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071

Query: 2010 SDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELD 2069
            + P  +                      + +P    P SP   P+    KG P       
Sbjct: 1072 ATPSLK---------------------GAPTPPAATPPSPKGGPATPSPKGAPMPPAATP 1110

Query: 2070 KSHLEGELRPKQPG---------PVKLGGEAAHLPHLRP-LPESQPSSSPLLQTAPGVKG 2119
             S   G   P   G         P   GG A   P   P  P + P S       P  KG
Sbjct: 1111 PSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKG 1170

Query: 2120 HQRVVTLAQHISEVITQDYTRHHPQ-QLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPP 2178
                           T   T   P+  L+ P P    + P A+ P      P   L  P 
Sbjct: 1171 ------------APTTPAATPPSPKGGLATPSPKGAPTTPAATPP-----SPKGGLATPS 1213

Query: 2179 PDHG--APARGSPHSEGGKRSPE----PNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAV 2232
            P      PA   P  +GG  +P     P   +       G     PP+G   P     A 
Sbjct: 1214 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTP----PAA 1269

Query: 2233 YPLLYRDGEQTEPSRMGSKSPGNTSQP 2259
             P   + G  T P + G+ +P   + P
Sbjct: 1270 TPPSLKGGLATPPHK-GAPNPAVVTPP 1295



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 129/595 (21%), Positives = 188/595 (31%), Gaps = 98/595 (16%)

Query: 1716 AAGPRGIIDLSQVPHLPVLVPPTPGTPATAMD---RLAYLPTAPQPFSSRHSSSPLSPGG 1772
            ++GP   I+ +  P   V+ P  P  P+T +    R+   P  P P   ++  S +    
Sbjct: 468  SSGPISNIEPTS-PAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKF 526

Query: 1773 PTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSS 1832
            PT     T  +S E       +     +++ ++L     V+ AP   P  + +S S    
Sbjct: 527  PTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVL---PLVQAAPKNSPSFQSTSSSPEIP 583

Query: 1833 GGGGGSSSRPASHSHAHQHSPISPRTQD-ALQQRPSVLHNTGMKGIITAVEPSTPTVLRS 1891
                 + ++ +         P S  T    +    SV+      G      P +   L  
Sbjct: 584  LSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAG------PDSAGPLLK 637

Query: 1892 TSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFL 1951
            +S  +P    A FP  +  P G                   AP  A+       T   FL
Sbjct: 638  SSLITPT--VAAFPLESADPAG------------------VAPTTAKGTSTYTTTASPFL 677

Query: 1952 AKPPARSGLEPASSPSKGS--EPRPLVPPVSGHATIARTPAKNLAP----------HHAS 1999
                    L P + P K       PLVP  S +  +A +P    AP            + 
Sbjct: 678  ---EGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSV 734

Query: 2000 PDPPAPPAS--------------------ASDPHREKTQSKPFSIQELELRSLGYHGSSY 2039
            P P  PPA                     AS P    T+    S       +L Y   S 
Sbjct: 735  PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794

Query: 2040 SPEGVEPVSPVSS--PSLTHDKGLPKHLEELDK--SHLEGELRPKQPGPVKLGGEAAHLP 2095
            SP GV  VSP +   P+     G    +  L    S +E    P+     +   ++    
Sbjct: 795  SPLGVS-VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATT 853

Query: 2096 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQH---ISEVITQDYTRHHPQQLSAPLPA 2152
            H    P  + + +P   T    KG    VTL         V+   + +  P    AP  A
Sbjct: 854  HSPTPPSPKGAPTPSAVTPLSPKG----VTLPPKETPTPSVVNLPFPKEGP-ATPAPKQA 908

Query: 2153 PLYSFPGASCPVLDLRRPPSDLYLPPPDHGA---PARGSPHSEGGKRSPEPNKTSVLGGG 2209
            P  S   +S         P  +   P   GA   PA   P  +GG  +P P         
Sbjct: 909  PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT---- 964

Query: 2210 EDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMG---SKSPGNTSQPPA 2261
                 P SP  G   P    +   P        T PS  G   + SP     PPA
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPP------AATPPSPKGGPATPSPKGAPTPPA 1013



 Score = 38.1 bits (87), Expect = 0.11
 Identities = 57/241 (23%), Positives = 87/241 (36%), Gaps = 40/241 (16%)

Query: 684  KKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK 743
            +K P      A  PP+  D     S  +G++  +   A A +       S     T   K
Sbjct: 1701 RKGPQTKKSSATSPPICPDP----SAKNGSKGPLSTVAPAPLLPVQKDSS----KTAKGK 1752

Query: 744  DTGQN--GPKPPATLGADGPPPGPP----TPPPEDIPAPTEPTPASEATGAPTPPPAPPS 797
            D   +  GP  P    A  P          P PE       P+P      AP+P P  P 
Sbjct: 1753 DASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPP 1812

Query: 798  -----PSAP--------PPVVPKEEKE-------EETAAAPPVEEGEEQKP-PAAEELAV 836
                 PS+P         P+ P +E E       E  +   P +      P P +  + V
Sbjct: 1813 KQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPV 1872

Query: 837  DTGKAEEPV----KSECTE-EAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKS 891
             T  A++PV    K   TE +++E   + ++ ++ +AT + A  A   E      + AK 
Sbjct: 1873 PTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQ 1932

Query: 892  S 892
            S
Sbjct: 1933 S 1933



 Score = 37.7 bits (86), Expect = 0.14
 Identities = 57/215 (26%), Positives = 75/215 (34%), Gaps = 32/215 (14%)

Query: 1002 PRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGD---PPCWTSGLPFPVPPREVIKASP 1058
            P  +   P P A+  A  P+        A   PG    PPC  S  P   P     +ASP
Sbjct: 10   PATEQELPQPQAET-AVLPMSSALSVTAALGQPGPTLPPPC--SPAPQQCPLSAANQASP 66

Query: 1059 HAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQ 1118
              P PS  +  P   P P     TA P+   P   +  P LI     P+ L     A++ 
Sbjct: 67   F-PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL-----ALAS 120

Query: 1119 GMSVQLHVPYSEHAKAPVGPVTMGLP---LPMDPKKLAPFSGVKQEQLSPRGQAGPPESL 1175
             M               + P   G P    P+    LAP S  K     P     PP S+
Sbjct: 121  PM---------------IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPP-SV 164

Query: 1176 GVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPS 1210
             V  +     L      S P  ++ K +PS  VP+
Sbjct: 165  AVAESGSVITLSAPIAPSEPKTNLNK-VPSEVVPN 198



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 75/320 (23%), Positives = 112/320 (35%), Gaps = 24/320 (7%)

Query: 722  EATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTP 781
            EAT    +  + +P P  E A     +     A LG  GP     T PP   PAP +  P
Sbjct: 4    EATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGP-----TLPPPCSPAP-QQCP 57

Query: 782  ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841
             S A  A +P P+P + ++ P  VP  +    TA   P+    E        +      A
Sbjct: 58   LSAANQA-SPFPSPSTIASTPLEVPFPQSSSGTAL--PLGTAPEAPTFLPNLIGPPISPA 114

Query: 842  EEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSS 901
               + S       +G        A  A A  ++  +K         T+  S A  +S S 
Sbjct: 115  ALALASPMIAPTLKGTPSSSAPLALVALAPHSV--QKSSAFPPNLLTSPPSVAVAESGSV 172

Query: 902  ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQV 961
             T SA         + N++    PS + P  +P+   SP  P  +  +      + P+  
Sbjct: 173  ITLSAPIAPSEPKTNLNKV----PSEVVP--NPKGTPSP--PCIVSTVPYH--CVTPMAS 222

Query: 962  TKVHEPPREDAAPTKPAPPAPPPPQNLQPES--DAPQQPGS-SPRGKSRSPAPPADKEAE 1018
             +          PT     A P  ++    S   +PQ PGS S +G    PA  +     
Sbjct: 223  IQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQS 282

Query: 1019 KPVFFPAFAAEAQKLPGDPP 1038
             PV   +        P D P
Sbjct: 283  LPVVTSSQKTAGPNTPPDFP 302



 Score = 35.4 bits (80), Expect = 0.70
 Identities = 48/241 (19%), Positives = 81/241 (33%), Gaps = 39/241 (16%)

Query: 685  KAPAAASEEAAFPPVVEDEEMEASGVSGNEEEM------VEEAEATVNNSSDTESIPSPH 738
            K P +    A   PV +D    A G   +            +A   +  ++  + +P P 
Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPE 1786

Query: 739  TEAAKDTGQNGPKPPATLGADGPPPGPPTPPPED---------IPAPTEP-TPASEATGA 788
            + +        P PP +L    P P P  PP +          + +P++P  PA E    
Sbjct: 1787 SASVSAA----PSPPVSLPL-APSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELL 1841

Query: 789  PTPPPAP--------------PSP---SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA 831
            P  PP P              P+P     P P    ++   +       E   ++  P  
Sbjct: 1842 PLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPEL 1901

Query: 832  EELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKE-GGSGRATTAK 890
            EE        ++   +   E  EE  +K K + + +   +   K   ++  G  R T  K
Sbjct: 1902 EEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRK 1961

Query: 891  S 891
            S
Sbjct: 1962 S 1962


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 139/631 (22%), Positives = 208/631 (32%), Gaps = 107/631 (16%)

Query: 483  VRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDK 542
            VRR   R  +     ++ +++   ++Q+      + E++E+E++ + +  +++ E END 
Sbjct: 1019 VRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDD 1078

Query: 543  EDLLKEKTDDTSGEDNDEKEAVA---SKGRKTANSQGRRKGRITRSMANEANSEEAITPQ 599
            ED    +  +    D+DE+E V+   SK   T++S+         S ++E  S    +P 
Sbjct: 1079 EDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSES--------SESSEFESSSESSPS 1130

Query: 600  QSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKR 659
             S +   +   E     EEE   A++ +   G                            
Sbjct: 1131 SSEDEEEVVAREEEEEEEEEEMVAEESMASAGPE-------------------------- 1164

Query: 660  QNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEE-EMV 718
                          E++         APA  S       + E+ ++E   V+  E   M+
Sbjct: 1165 ------------DFEQDGEEAALAPGAPAVDS-----LGMEEEVDIETEAVAPEERPSML 1207

Query: 719  EEAEATVNNSSDTESIPSPHTEAAKDTGQN--GPKPPATLGADGPPPGPPTPPPEDIPA- 775
            +E    V      +S   P        G     P+PPA      PP  P   P  D+   
Sbjct: 1208 DEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVE 1267

Query: 776  PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835
            P  P         P PPP PP P +PP   P+ E  + +  + P E   E  PP    L 
Sbjct: 1268 PEPPMMLPLPLQPPLPPPRPPRPPSPP---PEPETTDASHPSVPPEPLAEDHPPHTPGLC 1324

Query: 836  VDTGKAEEPVKSECTEEAE---EGPAKGKDAEAAEATAE----GALKAEKKEGGSGRATT 888
                K++       T   E    G + G    + +         A       GG  R   
Sbjct: 1325 GSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384

Query: 889  AKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQ 948
               S  P  S+ S            G    R       +L  TG P     P  PL L  
Sbjct: 1385 RDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLP-LPLPL-- 1441

Query: 949  LKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRS 1008
                  A+P +   +   P      P  PAP A  PP    P    P +P  SP      
Sbjct: 1442 ------ALPAVLRAQARAP--TPLPPLLPAPLASCPP----PMKRKPGRPRRSPPSMLSL 1489

Query: 1009 PAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSY 1068
              P       +P    A   E   LPG P         PV P      S H P      +
Sbjct: 1490 DGP-----LVRPPAGAALGRELLLLPGQPQT-------PVFP------STHDPRTVTLDF 1531

Query: 1069 APPGHPLPLGLHDTARPVLPRPPTISNPPPL 1099
               G P P        P+ P+PP    PPP+
Sbjct: 1532 RNAGIPAP------PPPLPPQPPPPPPPPPV 1556



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 89/406 (21%), Positives = 153/406 (37%), Gaps = 73/406 (17%)

Query: 780  TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839
            TP   A   P        P+ P  +    E++E+ + +   E  EE++    EE      
Sbjct: 1005 TPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEE------ 1058

Query: 840  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899
              EE    + +++ +E     +D   +EA+ +    ++++E  S   + A+++ + + S+
Sbjct: 1059 -EEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSE 1117

Query: 900  SSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQK--PLDLKQLKQRAAAIP 957
            SS   S+ E   +   D+  +++          +  A  S     P D +Q  + AA  P
Sbjct: 1118 SSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP 1177

Query: 958  PIQVTKVHEPPREDAAPTKPAPPA--------PPPPQNLQPESDA---PQQPGSSPRGKS 1006
                        E    T+   P         PP P  ++  +D+   P++PG S  G  
Sbjct: 1178 GAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAM 1237

Query: 1007 R-SPAPPADKEAEKPVFFPAFAAEAQ-KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1064
              SP PPA +   +P   P  A E   ++  +PP     LP P+ P              
Sbjct: 1238 LLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMM---LPLPLQP-------------- 1280

Query: 1065 AFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL--ISSAKHPSVLERQI--------- 1113
                     PLP           PRPP   +PPP    + A HPSV    +         
Sbjct: 1281 ---------PLPP----------PRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTP 1321

Query: 1114 ---GAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156
               G++++  S +  VP +   + P+   + GL L       +PFS
Sbjct: 1322 GLCGSLAKSQSTET-VPATPGGEPPLSGGSSGLSLSSPQVPGSPFS 1366



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 115/499 (23%), Positives = 156/499 (31%), Gaps = 110/499 (22%)

Query: 750  PKPPATLGADGPPPGPPTPPP-------------EDIPAPTEPTPASEATGA-------- 788
            P+  AT  A  PPP   TP P                P P E   A+ A GA        
Sbjct: 372  PQDSATF-AHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRR 430

Query: 789  -PTPPPAPPS-------PSAPPPVVPKEEKEEETAAAPPVEEGEE----------QKPPA 830
             P PPP PP+       P  PP   P +    E    P      E          +  PA
Sbjct: 431  APAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPA 490

Query: 831  AEELAVDT--GKAEEPVKSECTE-------------EAEEGPAKGKDAEAAEATAEGALK 875
              E   D+   + E  +K + T+             + E  P     ++ +     G   
Sbjct: 491  GPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNS 550

Query: 876  AEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPR 935
                 G +  ++   S+G  +D   +    +DE +E + G     L PRP       DP 
Sbjct: 551  QPGFRGPTPPSSRPSSTGL-EDISPTPLPDSDEDEELDLG-----LGPRPPPEPGPPDPA 604

Query: 936  ANASPQKPLDLKQLKQRAAAIPPI----QVTKVHEPPREDAAPTKPAPPAP-PPPQNLQP 990
               S    + L  +  R      +    Q +       +D  P+ P   A  P P  + P
Sbjct: 605  GLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTP 664

Query: 991  ESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPP 1050
             + A   P          P PP       P  FP        LP  PP       FP+PP
Sbjct: 665  GAAAVAAPSVL---APTLPLPP-------PPGFP-------PLPPPPPPPPPQPGFPMPP 707

Query: 1051 REVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL------ISSAK 1104
               +   P  P P+  +   P  PLP      A P +P PP +   PP       +    
Sbjct: 708  --PLPPPPPPPPPAHPAVTVPPPPLP------APPGVPPPPILPPLPPFPPGLFPVMQVD 759

Query: 1105 HPSVLERQIGAISQGMSVQLHV-----------PYSEHAKAPVGPVTMGLPLPMDPKKLA 1153
               VL  Q G +     +Q  V           PY     A     + GL     P    
Sbjct: 760  MSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRG 819

Query: 1154 PFSGVKQEQLSPRGQAGPP 1172
            PFS         RGQ  PP
Sbjct: 820  PFS--LSNSGPGRGQHWPP 836



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 35/116 (30%), Positives = 42/116 (36%), Gaps = 8/116 (6%)

Query: 712 GNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKP----PATLGADGP----PP 763
           G+     E+ +    +S +   I      +A  T  + PKP    P       P    P 
Sbjct: 619 GDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPT 678

Query: 764 GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819
            P  PPP   P P  P P     G P PPP PP P  PPP  P          APP
Sbjct: 679 LPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPP 734



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 119/527 (22%), Positives = 162/527 (30%), Gaps = 103/527 (19%)

Query: 1740 GTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTK--PTTTSSSERERDRDRERDR 1797
            GTP T        P    PFS   S S   P  P++L    P  T  + R   +  +   
Sbjct: 272  GTPLT--------PRLGTPFSQDSSYSSRQPT-PSYLFSQDPAVTFKARRHESKFTDAYN 322

Query: 1798 DREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSPISPR 1857
             R     +  S      A         S    G+ GG GGSS  P             P+
Sbjct: 323  RRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFK---------AQPQ 373

Query: 1858 TQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCP-----L 1912
                    P     T   G  +A  P                P A FPP    P      
Sbjct: 374  DSATFAHTPPPAQATPAPGFKSAFSPYQT-------------PVAHFPPPPEEPTATAAF 420

Query: 1913 GGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEP 1972
            G    G +     P  LP   P     E+P    G      PP  + +E    P+ G  P
Sbjct: 421  GARDSGEFRRAPAPPPLPPAEPLAK--EKPGTPPG----PPPPDTNSMELGGRPTFGWSP 474

Query: 1973 RPLVPPVSGHATIARTPAKNLAPHHASP--------DPPAPPASASDPHRE---KTQSKP 2021
             P   P  G  T+  +PA    PH +          +         +P  +   + +  P
Sbjct: 475  EPCDSP--GTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSP 532

Query: 2022 FSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL-PKHLEELDKSH-LE---GE 2076
             S    +L  L   G++  P    P  P S PS T  + + P  L + D+   L+   G 
Sbjct: 533  ISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGP 592

Query: 2077 LRPKQPGPVKLGGEAAHLPHLR-PLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2135
              P +PGP    G  +    +   L   +  +S  +       G    ++  +  S  IT
Sbjct: 593  RPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPIT 652

Query: 2136 QDYTRHHPQQLSAPLPAPLYSFPGASC--------PVLDLRRPPSDLYLPPPDHGAPARG 2187
                       SA  P P+   PGA+         P L L  PP    LPPP    P   
Sbjct: 653  -----------SADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPP--- 698

Query: 2188 SPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYP 2234
                      P+P        G     P+ PP     P H    V P
Sbjct: 699  ----------PQP--------GFPMPPPLPPPPPPPPPAHPAVTVPP 727



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 35/110 (31%), Positives = 46/110 (41%), Gaps = 13/110 (11%)

Query: 700 VEDEEMEASGVSGNE--EEMVEE--AEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPAT 755
           + D+EM ++ ++  +  + MV    A A    S    ++P P            P PP  
Sbjct: 641 ISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQ 700

Query: 756 LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVV 805
            G   PPP PP PPP        P PA  A   P PPP P  P  PPP +
Sbjct: 701 PGFPMPPPLPPPPPP--------PPPAHPAVTVP-PPPLPAPPGVPPPPI 741



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 26/75 (34%), Positives = 29/75 (38%), Gaps = 5/75 (6%)

Query: 761  PPPGPPTPPPEDIPAPTEPT--PASEATGAPTPPPAPPSPSAPPPVVPKE---EKEEETA 815
            PPP PP PPP   P P EPT  P  E          PP P     V  +     K     
Sbjct: 1540 PPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPW 1599

Query: 816  AAPPVEEGEEQKPPA 830
              PP +  E+  PPA
Sbjct: 1600 RRPPKKRHEDLVPPA 1614



 Score = 37.4 bits (85), Expect = 0.18
 Identities = 38/121 (31%), Positives = 47/121 (38%), Gaps = 28/121 (23%)

Query: 748  NGP--KPPA--TLGAD-----GPPPGPPTPPPED------------IPAPTEPTPASEAT 786
            +GP  +PPA   LG +     G P  P  P   D            IPAP  P P     
Sbjct: 1490 DGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQ--- 1546

Query: 787  GAPTPPPAPPSPSAPPPVVPKE-EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPV 845
              P PPP PP P  P  +  KE + +  + A PP   G ++      ELA   G    P 
Sbjct: 1547 --PPPPPPPP-PVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPP 1603

Query: 846  K 846
            K
Sbjct: 1604 K 1604



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 105/444 (23%), Positives = 143/444 (32%), Gaps = 86/444 (19%)

Query: 1781 TTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSS 1840
            T  S   E+D   E D D E   SI+TS               +++ SS SS      SS
Sbjct: 1081 TALSEASEKD---EGDSDEEETVSIVTSKA-------------EATSSSESSESSEFESS 1124

Query: 1841 RPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMK----------GIITAVEPSTPTV-- 1888
              +S S +     +  R ++  ++   ++    M           G   A+ P  P V  
Sbjct: 1125 SESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDS 1184

Query: 1889 --------LRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPE 1940
                    + + + +   RP+    P     +    D   P   E   L +E   +  PE
Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPP--EEPGLSQEGAMLLSPE 1242

Query: 1941 RPRADTGHAFLAKPPARSGLEPASSPSKGSE----------------------PRPLVPP 1978
             P  +      A+PP    L P  +P    E                      PRP  PP
Sbjct: 1243 PPAKEVE----ARPP----LSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294

Query: 1979 VSGHATIA---RTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYH 2035
                 T A     P + LA  H    P    + A     E   + P     L   S G  
Sbjct: 1295 PEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLS 1354

Query: 2036 GSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLP 2095
             SS    G     P  SPSL+   GLP+     D S       P   GP+ L      LP
Sbjct: 1355 LSSPQVPGSPFSYPAPSPSLS-SGGLPR-TPGRDFSFTPTFSEPS--GPLLL--PVCPLP 1408

Query: 2096 HLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLP-APL 2154
              R    S P +SP+L            + L   +  V+          Q  AP P  PL
Sbjct: 1409 TGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLR--------AQARAPTPLPPL 1460

Query: 2155 YSFPGASCPVLDLRRPPSDLYLPP 2178
               P ASCP    R+P      PP
Sbjct: 1461 LPAPLASCPPPMKRKPGRPRRSPP 1484



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 66/312 (21%), Positives = 98/312 (31%), Gaps = 33/312 (10%)

Query: 1719 PRGIIDLSQVPHLPVLVPPTPGTPATAMDRL--AYLPTAPQPFSSRHSSSPLSPGGPTHL 1776
            P  ++ L   P LP   PP P +P    +    ++    P+P +  H   P +PG    L
Sbjct: 1270 PPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHP--PHTPGLCGSL 1327

Query: 1777 TKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGG 1834
             K  +T +       +            +  S+  V  +P   P    S  S G   + G
Sbjct: 1328 AKSQSTETVPATPGGEPPLSGG---SSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384

Query: 1835 GGGSSSRPASHSHAHQHSPISPRTQDALQQRPS-----VLHNTGMKGIITAVEP---STP 1886
               S +   S        P+ P       +R       VL  TG+   +    P   + P
Sbjct: 1385 RDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALP 1444

Query: 1887 TVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADT 1946
             VLR+ + +    P     P   CP         P    P +L  + P            
Sbjct: 1445 AVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGP------------ 1492

Query: 1947 GHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPP 2006
                L +PPA + L        G    P+ P      T+         P    P PP PP
Sbjct: 1493 ----LVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP 1548

Query: 2007 ASASDPHREKTQ 2018
                 P  E T+
Sbjct: 1549 PPPPPPPVEPTK 1560



 Score = 32.7 bits (73), Expect = 4.5
 Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 13/124 (10%)

Query: 95   LGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPP 154
            LG  E   IE++    E  P  L  P   +   +PA S +  ++  L+ +   +  P PP
Sbjct: 1185 LGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPP 1244

Query: 155  HTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPV 214
                E+E  PP LS E   ++   V+ E  M+      L    Q        PP P +P 
Sbjct: 1245 AK--EVEARPP-LSPERAPEHDLEVEPEPPMM------LPLPLQP----PLPPPRPPRPP 1291

Query: 215  SPPP 218
            SPPP
Sbjct: 1292 SPPP 1295


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 163/657 (24%), Positives = 225/657 (34%), Gaps = 105/657 (15%)

Query: 546  LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRS-MANEANSEEAITPQQSAEL 604
            +KE+ D  SG+ +       S+G  +    GR+K   +     +  N +   + + S   
Sbjct: 5    VKEEDDGLSGKHSMRTRR--SRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSA 62

Query: 605  ASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE 664
            AS   N+S      + ET KK            A+ V  +  S  K+      KRQ    
Sbjct: 63   ASTSSNDS------KAETVKKS-----------AKKVKEEASSPLKS-----NKRQ---- 96

Query: 665  ILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEAT 724
               + K+  + E   R   KK           P   E E  ++  V  N+E   +  +  
Sbjct: 97   ---REKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSV--NDEGSSDPKDID 151

Query: 725  VNNSSDTESIPSPH-TEAAKDTGQNGP----KPPATLGADGPPPGPPTPPPEDIPAPTE- 778
             +N S + SIPSP   E+  D+         +PPA     G  P P + PP     PT  
Sbjct: 152  QDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 211

Query: 779  PTPASEAT---GAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQKPPAAEE 833
            PTP++ A    G+PT   AP  P AP   VP    ++  A  P  P        P     
Sbjct: 212  PTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP 271

Query: 834  LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSG 893
            L   TG A +P          + P  G+      +   G L               +  G
Sbjct: 272  LQPLTGSAGQP----SAPSHAQPPLHGQGPPGPHSLQAGPL--------------LQHPG 313

Query: 894  APQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRA 953
             PQ        S     +A  G       P  SL  P     A  S Q P        R 
Sbjct: 314  PPQPFGLPPQASQ---GQAPLGTSPAAAYPHTSLQLPASQ-SALQSQQPP--------RE 361

Query: 954  AAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPA 1013
              +PP  +   H  P     PT P P  P P  +  P    P   G SP   + +  PP 
Sbjct: 362  QPLPPAPLAMPHIKP----PPTTPIPQLPAPQAHKHP----PHLSGPSPFSMNANLPPP- 412

Query: 1014 DKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREV--IKASPHAPDPSAFSYAPP 1071
               A KP+   +        P          P P  P +   +  S + P P      P 
Sbjct: 413  --PALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPP------PA 464

Query: 1072 GHPLPLGLHDTA-RPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSE 1130
             HP P GLH  A +P   + P +   PP I+    PS      G    G S Q   P   
Sbjct: 465  SHP-PTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAG---PGTSAQ---PPCS 517

Query: 1131 HAKAPVGPVTMG--LPLP-MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEAS 1184
             A A  G +  G   PLP +  K+ A     + E   P  ++  PE   V T   AS
Sbjct: 518  GAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHAS 574



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 87/379 (22%), Positives = 132/379 (34%), Gaps = 58/379 (15%)

Query: 1786 ERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASH 1845
            ERER++++E++R+RERE+                   E    +  SS    G  S P   
Sbjct: 627  EREREKEKEKERERERERE-----------------REAERAAKASSSAHEGRLSDPQLS 669

Query: 1846 SHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSP-VRPAATF 1904
               H      P         P +  +T    + T  E + P V+  T+ + P   P    
Sbjct: 670  GPGHMRPSFEPPPTTIAAVPPYIGPDT--PALRTLSEYARPHVMSPTNRNHPFYMPLNPT 727

Query: 1905 PP--ATHCPLGGTLDGVYPTLMEPVLLPKE-APRVARPERPRADTGHAFLAKPPARSGLE 1961
             P  A H P    L  V PT+ E  L  +E   R  R    R      F  KPP    L 
Sbjct: 728  DPLLAYHMP---GLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH 784

Query: 1962 PASSPSK--GSEPRPLVPPVSGHATIARTPAKNLAPH-HASPDPPAPPASASDPHREKTQ 2018
            PA++P +         +PP +G             PH  AS  P   P           Q
Sbjct: 785  PAANPMEHFARHSALTIPPTAG-------------PHPFASFHPGLNPLERERLALAGPQ 831

Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078
             +P       L +   H    +    +P++ +   ++T     P H +    SH+   L 
Sbjct: 832  LRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVT-----PHHHQH---SHIHSHLH 883

Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ--HISEVITQ 2136
              Q  P+  G      P + PL     ++ P L   P   G      L Q  H  E++  
Sbjct: 884  LHQQDPLHQGSAGPVHPLVDPL-----TAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRH 938

Query: 2137 D-YTRHHPQQLSAPLPAPL 2154
              +   +P+ L   +P P+
Sbjct: 939  PVFGTPYPRDLPGAIPPPM 957



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 197/932 (21%), Positives = 300/932 (32%), Gaps = 229/932 (24%)

Query: 1389 KTQALGPLKL-KPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTP 1447
            K +A  PLK  K   E + +  +EA R+  +  + +    P  P       EG  +    
Sbjct: 83   KEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEG----EGESSDSRS 138

Query: 1448 LKYDTGASTTGSKKHDVRSLIGSPGRTFPPV-HPLDVMADARALERACYEESLKSRPGTA 1506
            +  D G+S       D RS       T P +  P D  +D+   + +  ++ L+++P   
Sbjct: 139  VN-DEGSSDPKDIDQDNRS-------TSPSIPSPQDNESDS---DSSAQQQMLQAQPPAL 187

Query: 1507 SSSGG--SIARGAPVIVPELGKPRQSP--LTYEDHGAPFAGHLPRGSPVTTREPTPRL-- 1560
             +  G       AP   P+L  P  +P        G+P A   P   P     P P    
Sbjct: 188  QAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN-QPQAPTAPVPHTHI 246

Query: 1561 -QEGSLSSSKASQD------------RKLTSTPREIAKSPHSTVPEH------------- 1594
             Q  +L   +                + LT +  + +   H+  P H             
Sbjct: 247  QQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAG 306

Query: 1595 ----HPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPR------ 1644
                HP P  P+    +   G     +    A+  TS+       A  +   PR      
Sbjct: 307  PLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPP 366

Query: 1645 ------HLAPNPTYP---------HLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHN 1689
                  H+ P PT P         H +PP+L    P +             ++S   HH 
Sbjct: 367  APLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHH- 425

Query: 1690 AATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRL 1749
              +A      ++    P  SS      A P G   L+Q  +LP   PP    P T + ++
Sbjct: 426  PPSAHPPPLQLMPQSQPLPSS-----PAQPPG---LTQSQNLP---PPPASHPPTGLHQV 474

Query: 1750 AYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTST 1809
            A     PQP  ++H   P  PGGP  +T PT  S+S                        
Sbjct: 475  A-----PQPPFAQH---PFVPGGPPPITPPTCPSTS------------------------ 502

Query: 1810 TTVEHAPIWRPGTEQSSGSSGSSGGGG---GSSSRP-------------ASHSHAHQHSP 1853
                  P   PGT      SG++  GG   G SS P             A    +    P
Sbjct: 503  -----TPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPP 557

Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913
             SP  +  +   PS  H +        ++    +  R+     P+              G
Sbjct: 558  RSPSPEPTVVDTPS--HASQSARFYKHLDRGYNSCARTDLYFMPL-------------AG 602

Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPR---------------ADTGHAFLAKPPARS 1958
              L       +E     +EA + AR ER R                +   A  A   A  
Sbjct: 603  SKLAKKREEAIEKA--KREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHE 660

Query: 1959 G------LEPASSPSKGSEPRP----LVPPVSGHATIA-RTPAKNLAPHHASP----DPP 2003
            G      L          EP P     VPP  G  T A RT ++   PH  SP     P 
Sbjct: 661  GRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPF 720

Query: 2004 APPASASDP-----------------HRE--KTQSKPFSIQELELRSLGYHGSSYSPEGV 2044
              P + +DP                  RE  + + +   I+E ELR     G    P  +
Sbjct: 721  YMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPEL 780

Query: 2045 EPVSPVSSP--------SLTHDKGLPKH--------LEELDKSHLE---GELRPKQPGPV 2085
            +P+ P ++P        +LT       H        L  L++  L     +LRP+   P 
Sbjct: 781  DPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPD 840

Query: 2086 KLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVT-LAQHISEVITQDYTRH-HP 2143
            +L  E  H   +  L     +   +    P    H  + + L  H  + + Q      HP
Sbjct: 841  RLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHP 900

Query: 2144 --QQLSAPLPAPLYSFPGASCPVLDLRRPPSD 2173
                L+A      + +P  + P   L +PP +
Sbjct: 901  LVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 932



 Score = 39.7 bits (91), Expect = 0.037
 Identities = 73/314 (23%), Positives = 107/314 (34%), Gaps = 36/314 (11%)

Query: 1953 KPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDP 2012
            K  A+   E ASSP K S  R      S      RT +K       S      P S S+ 
Sbjct: 76   KKSAKKVKEEASSPLK-SNKRQREKVASDTEEADRTSSKKTKTQEISR-----PNSPSEG 129

Query: 2013 HREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSH 2072
              E + S          RS+   GSS  P+ ++  +  +SPS+      P+  E    S 
Sbjct: 130  EGESSDS----------RSVNDEGSS-DPKDIDQDNRSTSPSIPS----PQDNESDSDSS 174

Query: 2073 LEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISE 2132
             + ++   QP  ++          + P P S P  +P L T         V         
Sbjct: 175  AQQQMLQAQPPALQAP------TGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSP--- 225

Query: 2133 VITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSE 2192
              T     + PQ  +AP+P           P L  +RPPS    P P    P +    S 
Sbjct: 226  --TASQAPNQPQAPTAPVPHTHIQ----QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 279

Query: 2193 GGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKS 2252
            G   +P   +  + G G  G   +     +  PG  +    P     G+    +   +  
Sbjct: 280  GQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 339

Query: 2253 PGNTSQPPAFFSKL 2266
            P  + Q PA  S L
Sbjct: 340  PHTSLQLPASQSAL 353



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 42/185 (22%), Positives = 61/185 (32%), Gaps = 25/185 (13%)

Query: 670 KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729
           KL  ++E    + K++A   A EE        ++E E       E E   E  A  ++S+
Sbjct: 604 KLAKKREEAIEKAKREAEQKAREERE-----REKEKEKEREREREREREAERAAKASSSA 658

Query: 730 DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI-----PAPTEPTPASE 784
               +  P          +   PP T+ A  P  GP TP    +     P    PT  + 
Sbjct: 659 HEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNH 718

Query: 785 ATGAPTPPPAP------PSPSAPPPVVPKEEKEEETAAAPPVEE---------GEEQKPP 829
               P  P  P      P      P + + E  E       + E         G E KPP
Sbjct: 719 PFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPP 778

Query: 830 AAEEL 834
             + L
Sbjct: 779 ELDPL 783



 Score = 32.0 bits (71), Expect = 7.7
 Identities = 12/45 (26%), Positives = 28/45 (62%)

Query: 491 GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEK 535
           G    +++++  ++ +++ +   R  +E + EKEKE+E E+E E+
Sbjct: 602 GSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERERER 646


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 140/668 (20%), Positives = 222/668 (33%), Gaps = 106/668 (15%)

Query: 556  EDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRW 615
            ++ D        GR     +  + G       +   SE+ +  +  + ++  E    +  
Sbjct: 85   QELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDL 144

Query: 616  TEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEK 675
             EE   +   G L      SA+     S  V++   F        + +E  ++ K+ ++K
Sbjct: 145  KEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEASQEETTKKQKV-VQK 198

Query: 676  ERNARRKKKKAPAAASEEAAFP--------PVVEDEEMEASGVSGNEEEMVEEAEATVNN 727
            E+       K P         P        P+ +D   ++  +S  + E ++        
Sbjct: 199  EQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS--ISSQQPEKIKSQPPGTGK 256

Query: 728  SSDTESIPSPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPA 782
                 +  +P T+ AK   Q     P T  AD        P  P+P    I  PT   P 
Sbjct: 257  PIQGPT-QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
            ++  G     P P  P A P  + K   ++     PPV+     KPPA         +  
Sbjct: 316  AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPL 366

Query: 843  EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA 902
             P K    +   E P+  +    A A   G  K   ++ G  +  T +  G P+      
Sbjct: 367  GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQP 425

Query: 903  TCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVT 962
               +    +A G  K  +  P P  +     P   A P K       +Q     PP Q+ 
Sbjct: 426  GLQSPA--KAPGPTKTPVQQPGPGKI-----PAQQAGPGKT----SAQQTGPTKPPSQLP 474

Query: 963  KVHEPPREDAAPTKPAPPAP--------------PPPQNLQPESDAPQQPGSS------- 1001
               +PP +   P KP P  P              PPPQ   P   +PQQPGS+       
Sbjct: 475  GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534

Query: 1002 ----PRGKSRSPAPPADKEAEKPVFF---------PAFAAEAQKLPGDPPCWTSGLPFPV 1048
                P  +  SPA P+ +++ KPV           P  +  A++ P      + GLP  +
Sbjct: 535  GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP------SQGLPKTI 588

Query: 1049 PPR-EVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107
             P     +   H P+ + F+           L               NP P ++  K   
Sbjct: 589  CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG------------FNPNPHLTEVKEWL 636

Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRG 1167
             L  Q+     G      VP S   K    PVT               S  + +Q SP+ 
Sbjct: 637  CLNCQMKRALGGDLAP--VPSSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKK 686

Query: 1168 QAGPPESL 1175
             A P + L
Sbjct: 687  DAAPKQDL 694



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 94/438 (21%), Positives = 151/438 (34%), Gaps = 49/438 (11%)

Query: 735  PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 788
            P+PH    K+      +    LG D  P P  P P  +  P  T     + +P  + T +
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683

Query: 789  PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839
            P    AP       P P  PPP+V  P         A  P E     KP   +E +V + 
Sbjct: 684  PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743

Query: 840  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899
            + + PV  +  ++ +          ++ AT +  + + K +  +   TT      P  +D
Sbjct: 744  QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798

Query: 900  SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 956
            S+    +      +    +    PRP   S +     P + +  QK +D  Q K+     
Sbjct: 799  SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854

Query: 957  PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016
            P    TK+   P+ DA P     P PP P+    ++    Q    P+ +SR  +      
Sbjct: 855  PKKAQTKMS--PKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912

Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGH 1073
             + P          +  P  P    +G  F        +AS     A  P   S + PG 
Sbjct: 913  TDAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962

Query: 1074 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133
            P+         P   +PPT   PP     A         +   ++  + +   P +E A 
Sbjct: 963  PM------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 1134 APVGPVTMGLPLPMDPKK 1151
                  T   P P+   K
Sbjct: 1017 TVKRTETEKKPPPIKDSK 1034



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%)

Query: 1725 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1782
            +S+   LP    P     + +M R   L ++  P   + S  P  PG P    L+K  TT
Sbjct: 60   MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116

Query: 1783 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1840
             +   E+            ++S   +    EH     PG  +E ++ S+ SS     +  
Sbjct: 117  DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176

Query: 1841 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1878
               S S A Q      +              +  LQQ+P   +    G         G  
Sbjct: 177  DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236

Query: 1879 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1936
             ++    P  ++S    T  P++     P   H  L    D   P   +  ++  E+ + 
Sbjct: 237  KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296

Query: 1937 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 1996
            + P   +         KPPA+   +P    S+    +P   P      +A+ P     P 
Sbjct: 297  SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353

Query: 1997 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2054
                +  PPA P   + P  ++T S+  S ++   ++L            +P  P   P 
Sbjct: 354  QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411

Query: 2055 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2114
             T   G PK L +          +P    P K  G     P   P+ +  P   P  Q  
Sbjct: 412  -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455

Query: 2115 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2171
            PG    Q              Q      P QL  P   P    PG + P        +PP
Sbjct: 456  PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500

Query: 2172 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2228
            S       PPP    PA+ SP   G  + P     S     +         +  T+P   
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560

Query: 2229 RSAVYPL 2235
              +  PL
Sbjct: 561  TGSGKPL 567



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 95/391 (24%), Positives = 139/391 (35%), Gaps = 80/391 (20%)

Query: 840  KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 894
            K E PV    + +   +E+ P K    E         L+A  +KKE  + R  ++ S   
Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339

Query: 895  PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952
                 SS  A    +++              +P+   P+G P  ++ P KP    +    
Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399

Query: 953  AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSR 1007
              +  P        PP        P PP PPPP    P    P  P +SP+      K  
Sbjct: 2400 DISAQP--------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL 2443

Query: 1008 SPAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061
            + A P       P+F      E      +  LP    C T+  P PVPP+          
Sbjct: 2444 TVASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK---------- 2489

Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQG 1119
             PS+         +P GL  T RP   +PP    P  P L ++ + P+ +  +   +S  
Sbjct: 2490 -PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPES 1174
             S+ L++  S   K         LP P  P  L+P S     + S            P  
Sbjct: 2540 SSMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSE 2588

Query: 1175 LGVPTAQEASVLRGTALGSVPGGSITKGIPS 1205
             G PT   AS     A+ S P GS +K + S
Sbjct: 2589 PGTPTDSSAS----QAITSWPLGSPSKDLVS 2615



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%)

Query: 756  LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 812
            + A  PPP PP PPP                  P PPP PP P  PPP  PK     K++
Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 813  ETAAAP 818
             T A+P
Sbjct: 2443 LTVASP 2448



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%)

Query: 183  ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            ++++E Q S L  ++    E+  +P E  PE+P      +S   +L   I +E  K+++ 
Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 241  AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290
              +       Q ++P            +  +  R+ +++++ +       +   KRR   
Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 291  RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348
                  ++ Q   Q     E  + +  IE +    A  S+  E+   Q  EI    E Q+
Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593

Query: 349  RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389
            + +++               +  + +   A R       + E  +    L  +E   ++ 
Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653

Query: 390  RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448
             +L V          +R K I +N  +AD       ++  +++ ++E E   E     P 
Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709

Query: 449  -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507
             ++ G  +S L   +         ++  +E+  S          K + +QQ++ + +   
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764

Query: 508  QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567
               P    S EE++ +E+E+  +++E++ E+E  +    ++ +   S +D DE  A    
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816

Query: 568  GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613
                     RR+ R     +N +  E+A   ++  + A M EL+ SS
Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 69/321 (21%), Positives = 105/321 (32%), Gaps = 72/321 (22%)

Query: 708  SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK-DTGQNGPKPPATLGADGPPPGPP 766
            SG +  +E+   +  +   + S   + P P   ++  D     P PP       PPP PP
Sbjct: 2363 SGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP--PPPPPPPPP 2420

Query: 767  TPPPEDIPAPTEPTP----------ASEATGA---------------------------- 788
             PPP  +P PT P P          AS  T A                            
Sbjct: 2421 PPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICT 2480

Query: 789  PTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE----P 844
              PPP PP PS+ P  +    + E   + PP+        P   +L   T K  +    P
Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPE--PSKPPI-----APKPVIPQLPTTTQKPTDIHPKP 2533

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQ 896
                 T           D +    T+  +  + K      ++        T     G P 
Sbjct: 2534 TGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593

Query: 897  DSDSSATCSADEVDEAEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAA 954
            DS +S   ++  +    G     L+S  P  S++ P        + + P+  +Q    + 
Sbjct: 2594 DSSASQAITSWPL----GSPSKDLVSVEPVFSVVPPV------TAVEIPISSEQTFYISG 2643

Query: 955  AIPPIQVTKVHEPPREDAAPT 975
            A+     T V  P    AAPT
Sbjct: 2644 ALQTFSATPVTAPSSFQAAPT 2664



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%)

Query: 792  PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 845
            PPAP  P A P  VP E   ++TA  P    V++ E++    AE++ ++  K   + E +
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 846  KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 897
                T + ++  +K +  +A+    +  L  EKK             +    +    P+D
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245

Query: 898  SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 957
                        +E     K+ LL  +  +     + R   +P+   + KQ + +   +P
Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299

Query: 958  PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAP 1011
                  +   P+ED   TK     P PP   +P+   P      ++   S    S+ P  
Sbjct: 1300 SGTPQSL---PKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356

Query: 1012 P 1012
            P
Sbjct: 1357 P 1357



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 93/443 (20%), Positives = 149/443 (33%), Gaps = 71/443 (16%)

Query: 770  PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPP 829
            PE + A       +   G+P+    P    A    + +EE+ +  A     +   +   P
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72

Query: 830  AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE---AAEATAEGALKAEKKEGGSGRA 886
             A   +    + +E   S   +++   P  G+ A+   +   T +     +K  G S   
Sbjct: 73   PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132

Query: 887  TTAKSSGAPQDSDSSATCS-----ADEVD--EAEGGDKNRLLSPRPSLLTPTGDPRANAS 939
             + K S +  D       S       EV+   A     N+  +P   +            
Sbjct: 133  ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNK-FNPFDLISDSEASQEETTK 191

Query: 940  PQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP- 998
             QK +  +Q K      PP+Q     +PP+    P +  P   P  Q+  P+S + QQP 
Sbjct: 192  KQKVVQKEQGKPEGIIKPPLQ----QQPPK--PIPKQQGPGRDPLQQDGTPKSISSQQPE 245

Query: 999  ---------GSSPRGKSRSPAP-----PADKEAEKPVFFPAFAAEAQKL------PGDPP 1038
                     G   +G +++P       P  ++A +P    A     + +      P  PP
Sbjct: 246  KIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP 305

Query: 1039 CWTSGLPFP-VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-DTARPVLPRPPTISNP 1096
                  P P  PP +        P P+     P G   PL     T +P +  P T   P
Sbjct: 306  IQQ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPP 362

Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156
               +  AK P+   +Q G+           P SE                  PK LA   
Sbjct: 363  AQPLGPAKPPA---QQTGS---------EKPSSEQP---------------GPKALAQPP 395

Query: 1157 GVKQEQLSPRGQAGPP-ESLGVP 1178
            GV +      G A PP + +G P
Sbjct: 396  GVGKTPAQQPGPAKPPTQQVGTP 418



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 70/346 (20%), Positives = 112/346 (32%), Gaps = 57/346 (16%)

Query: 734  IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPP 793
            +  P    +       P    +L    PP  P  P  +D     +  P       PT   
Sbjct: 707  VKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDL 766

Query: 794  APPSPSAPPPVVP--KEEKEEETAAAPPVE----EGEEQKPPAAEELAVDTGKAEEPVKS 847
               S +   P +P  K + + E    PP++    +  +  PP  E+++    KA     S
Sbjct: 767  VSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS 826

Query: 848  ECTEEAEEGP---AKG--------KDAEAAEATAEGALKAEKKEGGSGRAT--------- 887
            +    +  GP   +KG        K  E  +A  + + K + K    G  T         
Sbjct: 827  DSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 888  ----TAKSSGAPQDSD---------------SSATCSADEVDEAEGGDKNRLLSPRPSLL 928
                T + S  PQ+                 S  T   + V     G    + S   +L+
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 929  TPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNL 988
            +  G P  ++       +KQ      A  P Q      PP+     T  APPAP     +
Sbjct: 947  STAGQPGPHSQSGPGAPMKQ------APAPSQPPTSQGPPKS----TGQAPPAPAKSIPV 996

Query: 989  QPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF--FPAFAAEAQK 1032
            + E+ AP      P+ +        + E + P      +  AE QK
Sbjct: 997  KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 78/369 (21%), Positives = 132/369 (35%), Gaps = 56/369 (15%)

Query: 509  QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565
            +QP P +    K    KE     E++K  V +DK     ++K  TD  S      K  + 
Sbjct: 721  KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779

Query: 566  SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625
            S                      ++ +EE  TP    +  S + ++S   T E++     
Sbjct: 780  SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818

Query: 626  GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685
              +    + S I    G  + S+ +      +K++      ++ + KM  + +A+   K 
Sbjct: 819  KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEP----KKAQTKMSPKPDAKPMPKG 874

Query: 686  APA------AASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT-------- 731
            +P        A +    P      + ++   S N   + +  ++      +T        
Sbjct: 875  SPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGF 934

Query: 732  -ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790
              SI S  +      GQ GP   +  GA       P+ PP     P       ++TG   
Sbjct: 935  GASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-------KSTGQAP 987

Query: 791  PPPAPPSPSAPPPVVPKEEK-EEETAAAPPVEEGE-EQKPPA---AEELAVDTGKAEEPV 845
            P PA   P       P  EK E +   AP V+  E E+KPP    ++ L  +  KA  P 
Sbjct: 988  PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047

Query: 846  KSECTEEAE 854
            K E + + E
Sbjct: 1048 KLEKSPKPE 1056



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 112/542 (20%), Positives = 188/542 (34%), Gaps = 74/542 (13%)

Query: 487  YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLL 546
            + + G     +Q     Q    Q P P+S+ +      K    +KE + P  E  +    
Sbjct: 955  HSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--- 1010

Query: 547  KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606
            K +   T      EK+    K  K+  ++ ++    T+        E++  P+ +  L  
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKL-------EKSPKPESTCPLCK 1063

Query: 607  MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFN---YKKRQNLD 663
             ELN  S+                              T ++CKN   N   +    +L 
Sbjct: 1064 TELNIGSKDPPN------------------------FNTCTECKNQVCNLCGFNPTPHLT 1099

Query: 664  EILQQHKLKMEKERNARRK----KKKAPAAASEEAAFPPVVEDEEMEASGV-------SG 712
            EI +   L  + +R    +    +K  PA +  +A+  PV  +   + + V         
Sbjct: 1100 EIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKK 1159

Query: 713  NEEEMVEEAEAT----VNNSSDTESIPSPHTEAAKDTGQNGPKPPAT-LGADGPPPGPPT 767
             E+E+  EAE      V  +   E IP   T   K       K  A+ L    P P    
Sbjct: 1160 QEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219

Query: 768  PPPEDIPAPTEPTPASEATGAPTPPPAPPSP----SAPPP---------VVPKEEKEEET 814
              PE+    +E          PTP      P    SAP           V   EEK E  
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279

Query: 815  AAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 874
             A   V+EG+ Q     E L   T ++      + T+  +E P     A+  +    G  
Sbjct: 1280 VAPKTVQEGK-QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP-DQVEPGKE 1337

Query: 875  KAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP 934
            K EK++  S  +++ +       SD+    S+D +  + G   + + +    +L      
Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGY--SSDGISSSLGEIPSLIPTDEKDILKGLKKD 1395

Query: 935  RAN--ASPQKPLDLKQLKQRAAAIPPIQV-TKVHEPPREDAAPTKPAPPAPPPPQNLQPE 991
              +  +SP  P DL +L+    +I   Q  T   E   +   P + +P  P   +  Q  
Sbjct: 1396 SFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL 1455

Query: 992  SD 993
            S+
Sbjct: 1456 SE 1457



 Score = 38.9 bits (89), Expect = 0.063
 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%)

Query: 1380 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1425
            P +DL++A + +   PL  +P   G  +             K A      +P E+ +   
Sbjct: 690  PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 1426 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1478
                P+ P   +P  +   +     K D  +S   S+  +     +++    P ++FPP 
Sbjct: 750  ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809

Query: 1479 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1538
                   D++A+ R   +  + S PG +S S G   +  PV   E  K  Q+ ++ +   
Sbjct: 810  GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865

Query: 1539 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1586
             P A  +P+GSP            V T + +P+ QE S   S       +T  P+    +
Sbjct: 866  -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922

Query: 1587 PHSTV 1591
            P  TV
Sbjct: 923  PQETV 927



 Score = 38.5 bits (88), Expect = 0.082
 Identities = 100/473 (21%), Positives = 160/473 (33%), Gaps = 56/473 (11%)

Query: 1930 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1980
            P EA  +++P  P+        D       KP     ++P +    S  +  +P +P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2039
              +         L    A P    PP      P   K   +P S  ++ +   G    S 
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841

Query: 2040 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2098
              + V+PV     P     K  PK   + + K        P  PGP    G+    P   
Sbjct: 842  GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895

Query: 2099 PLPESQPSSSPL----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL 2154
            P P+ Q     L    +  AP  +      T+   +       +++      +A  P P 
Sbjct: 896  PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGP- 954

Query: 2155 YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE 2214
            +S  G   P+     P      PP   G P         G+  P P K+  +       E
Sbjct: 955  HSQSGPGAPMKQAPAPSQ----PPTSQGPP------KSTGQAPPAPAKSIPVKK-----E 999

Query: 2215 PVSPPEGMTEPGHSRSAVYPLLYR-DGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAM 2273
              +P     EP   ++   P + R + E+  P    SKS     Q     +KL +S    
Sbjct: 1000 TKAPAAEKLEP---KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP- 1055

Query: 2274 VKSKKQEINKKLNTHNRNEPEYN-ISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMG 2332
             +S       +LN  +++ P +N  ++   ++ N+     T  +T     +QE    N  
Sbjct: 1056 -ESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT----EIQEWLCLNCQ 1110

Query: 2333 LEAIIRKALMGGGGKAKVSGRPSSRKAK-SPAPGLASGDR---PPSVSSVHSE 2381
             +  I   L   G   K+   PS  KA   P P  +S  +   PP V  V  +
Sbjct: 1111 TQRAISGQL---GDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160



 Score = 35.8 bits (81), Expect = 0.53
 Identities = 32/139 (23%), Positives = 47/139 (33%), Gaps = 13/139 (9%)

Query: 726  NNSSDTESIPSPHTEA----------AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA 775
            +N   T   P PH+++          A         PP + G   P P    P  ++  A
Sbjct: 943  SNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002

Query: 776  PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835
            P       +A  APT          PP    K    E   A  P +  +  KP +   L 
Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062

Query: 836  ---VDTGKAEEPVKSECTE 851
               ++ G  + P  + CTE
Sbjct: 1063 KTELNIGSKDPPNFNTCTE 1081



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%)

Query: 167  LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203
            +++ +++Q+   +DRE+ +VE++ +KL+KKQ +L+EE
Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 140/668 (20%), Positives = 222/668 (33%), Gaps = 106/668 (15%)

Query: 556  EDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRW 615
            ++ D        GR     +  + G       +   SE+ +  +  + ++  E    +  
Sbjct: 85   QELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDL 144

Query: 616  TEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEK 675
             EE   +   G L      SA+     S  V++   F        + +E  ++ K+ ++K
Sbjct: 145  KEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEASQEETTKKQKV-VQK 198

Query: 676  ERNARRKKKKAPAAASEEAAFP--------PVVEDEEMEASGVSGNEEEMVEEAEATVNN 727
            E+       K P         P        P+ +D   ++  +S  + E ++        
Sbjct: 199  EQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS--ISSQQPEKIKSQPPGTGK 256

Query: 728  SSDTESIPSPHTEAAKDTGQNGPKPPATLGAD-----GPPPGPPTPPPEDIPAPTEPTPA 782
                 +  +P T+ AK   Q     P T  AD        P  P+P    I  PT   P 
Sbjct: 257  PIQGPT-QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315

Query: 783  SEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAE 842
            ++  G     P P  P A P  + K   ++     PPV+     KPPA         +  
Sbjct: 316  AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---------QPL 366

Query: 843  EPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSA 902
             P K    +   E P+  +    A A   G  K   ++ G  +  T +  G P+      
Sbjct: 367  GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPT-QQVGTPKPLAQQP 425

Query: 903  TCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVT 962
               +    +A G  K  +  P P  +     P   A P K       +Q     PP Q+ 
Sbjct: 426  GLQSPA--KAPGPTKTPVQQPGPGKI-----PAQQAGPGKT----SAQQTGPTKPPSQLP 474

Query: 963  KVHEPPREDAAPTKPAPPAP--------------PPPQNLQPESDAPQQPGSS------- 1001
               +PP +   P KP P  P              PPPQ   P   +PQQPGS+       
Sbjct: 475  GPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQP 534

Query: 1002 ----PRGKSRSPAPPADKEAEKPVFF---------PAFAAEAQKLPGDPPCWTSGLPFPV 1048
                P  +  SPA P+ +++ KPV           P  +  A++ P      + GLP  +
Sbjct: 535  GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP------SQGLPKTI 588

Query: 1049 PPR-EVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107
             P     +   H P+ + F+           L               NP P ++  K   
Sbjct: 589  CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG------------FNPNPHLTEVKEWL 636

Query: 1108 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRG 1167
             L  Q+     G      VP S   K    PVT               S  + +Q SP+ 
Sbjct: 637  CLNCQMKRALGGDLAP--VPSSPQPKLKTAPVT--------TTSAVSKSSPQPQQTSPKK 686

Query: 1168 QAGPPESL 1175
             A P + L
Sbjct: 687  DAAPKQDL 694



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 94/438 (21%), Positives = 151/438 (34%), Gaps = 49/438 (11%)

Query: 735  PSPHTEAAKDTGQNGPKPPATLGAD-GPPPGPPTPPPEDIPAPT-----EPTPASEATGA 788
            P+PH    K+      +    LG D  P P  P P  +  P  T     + +P  + T +
Sbjct: 625  PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQT-S 683

Query: 789  PTPPPAP-------PSPSAPPPVV--PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG 839
            P    AP       P P  PPP+V  P         A  P E     KP   +E +V + 
Sbjct: 684  PKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743

Query: 840  KAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSD 899
            + + PV  +  ++ +          ++ AT +  + + K +  +   TT      P  +D
Sbjct: 744  QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-----PLKTD 798

Query: 900  SSATCSADEVDEAEGGDKNRLLSPRP---SLLTPTGDPRANASPQKPLDLKQLKQRAAAI 956
            S+    +      +    +    PRP   S +     P + +  QK +D  Q K+     
Sbjct: 799  SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE---- 854

Query: 957  PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016
            P    TK+   P+ DA P     P PP P+    ++    Q    P+ +SR  +      
Sbjct: 855  PKKAQTKMS--PKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912

Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS---PHAPDPSAFSYAPPGH 1073
             + P          +  P  P    +G  F        +AS     A  P   S + PG 
Sbjct: 913  TDAP----------KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGA 962

Query: 1074 PLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133
            P+         P   +PPT   PP     A         +   ++  + +   P +E A 
Sbjct: 963  PM------KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 1134 APVGPVTMGLPLPMDPKK 1151
                  T   P P+   K
Sbjct: 1017 TVKRTETEKKPPPIKDSK 1034



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 114/547 (20%), Positives = 177/547 (32%), Gaps = 75/547 (13%)

Query: 1725 LSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTH--LTKPTTT 1782
            +S+   LP    P     + +M R   L ++  P   + S  P  PG P    L+K  TT
Sbjct: 60   MSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPP---KQSGRPPDPGRPAQPGLSKSRTT 116

Query: 1783 SSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPG--TEQSSGSSGSSGGGGGSSS 1840
             +   E+            ++S   +    EH     PG  +E ++ S+ SS     +  
Sbjct: 117  DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPF 176

Query: 1841 RPASHSHAHQHSPISPRT-------------QDALQQRPS--VLHNTG-------MKGII 1878
               S S A Q      +              +  LQQ+P   +    G         G  
Sbjct: 177  DLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTP 236

Query: 1879 TAVEPSTPTVLRST--STSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV 1936
             ++    P  ++S    T  P++     P   H  L    D   P   +  ++  E+ + 
Sbjct: 237  KSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP 296

Query: 1937 ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH 1996
            + P   +         KPPA+   +P    S+    +P   P      +A+ P     P 
Sbjct: 297  SLPSPSKPPIQQPTPGKPPAQ---QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353

Query: 1997 H--ASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPS 2054
                +  PPA P   + P  ++T S+  S ++   ++L            +P  P   P 
Sbjct: 354  QPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP-GPAKPP- 411

Query: 2055 LTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTA 2114
             T   G PK L +          +P    P K  G     P   P+ +  P   P  Q  
Sbjct: 412  -TQQVGTPKPLAQ----------QPGLQSPAKAPG-----PTKTPVQQPGPGKIPAQQAG 455

Query: 2115 PGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDL---RRPP 2171
            PG    Q              Q      P QL  P   P    PG + P        +PP
Sbjct: 456  PGKTSAQ--------------QTGPTKPPSQLPGPAKPPPQQ-PGPAKPPPQQPGSAKPP 500

Query: 2172 SDL---YLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHS 2228
            S       PPP    PA+ SP   G  + P     S     +         +  T+P   
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560

Query: 2229 RSAVYPL 2235
              +  PL
Sbjct: 561  TGSGKPL 567



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 95/391 (24%), Positives = 139/391 (35%), Gaps = 80/391 (20%)

Query: 840  KAEEPVKSECTEE---AEEGPAKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGA 894
            K E PV    + +   +E+ P K    E         L+A  +KKE  + R  ++ S   
Sbjct: 2280 KPEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETV 2339

Query: 895  PQDSDSS--ATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952
                 SS  A    +++              +P+   P+G P  ++ P KP    +    
Sbjct: 2340 FDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSL 2399

Query: 953  AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-----GKSR 1007
              +  P        PP        P PP PPPP    P    P  P +SP+      K  
Sbjct: 2400 DISAQP--------PP--------PPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL 2443

Query: 1008 SPAPPADKEAEKPVFFPAFAAE------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061
            + A P       P+F      E      +  LP    C T+  P PVPP+          
Sbjct: 2444 TVASPV--TTATPLFDAVTTLETTAVLRSNGLPVTRICTTA--PPPVPPK---------- 2489

Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP--PPLISSAKHPSVLERQIGAISQG 1119
             PS+         +P GL  T RP   +PP    P  P L ++ + P+ +  +   +S  
Sbjct: 2490 -PSS---------IPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPR-----GQAGPPES 1174
             S+ L++  S   K         LP P  P  L+P S     + S            P  
Sbjct: 2540 SSMTLNLVTSADYK---------LPSPTSP--LSPHSNKSSPRFSKSLTETYVVITLPSE 2588

Query: 1175 LGVPTAQEASVLRGTALGSVPGGSITKGIPS 1205
             G PT   AS     A+ S P GS +K + S
Sbjct: 2589 PGTPTDSSAS----QAITSWPLGSPSKDLVS 2615



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 21/66 (31%)

Query: 756  LGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE---EKEE 812
            + A  PPP PP PPP                  P PPP PP P  PPP  PK     K++
Sbjct: 2401 ISAQPPPPPPPPPPP------------------PPPPPPPPPPPLPPPTSPKPTILPKKK 2442

Query: 813  ETAAAP 818
             T A+P
Sbjct: 2443 LTVASP 2448



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 85/467 (18%), Positives = 182/467 (38%), Gaps = 64/467 (13%)

Query: 183  ITMVEQQISKLKKKQQQLEEEAAKPPE--PEKPVSPPPIESKHRSLVQIIYDENRKKAEA 240
            ++++E Q S L  ++    E+  +P E  PE+P      +S   +L   I +E  K+++ 
Sbjct: 1417 LSILEAQASTLADEKS---EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473

Query: 241  AHRILEGLGPQVELP----------LYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHA 290
              +       Q ++P            +  +  R+ +++++ +       +   KRR   
Sbjct: 1474 ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 291  RKQWEQKFCQRYDQLMEAWEKKVER--IENNPRRRAKESKVREYYEKQFPEIRKQRELQE 348
                  ++ Q   Q     E  + +  IE +    A  S+  E+   Q  EI    E Q+
Sbjct: 1534 GSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593

Query: 349  RMQSR-------------VGQRGSGLSMSAAR------SEHEVSEIIDGLSEQENLEKQM 389
            + +++               +  + +   A R       + E  +    L  +E   ++ 
Sbjct: 1594 KEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES 1653

Query: 390  RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHP- 448
             +L V          +R K I +N  +AD       ++  +++ ++E E   E     P 
Sbjct: 1654 EELVVTG----GGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPE 1709

Query: 449  -KNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQ 507
             ++ G  +S L   +         ++  +E+  S          K + +QQ++ + +   
Sbjct: 1710 DRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHK-----KGESKQQRKARHRPHG 1764

Query: 508  QQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASK 567
               P    S EE++ +E+E+  +++E++ E+E  +    ++ +   S +D DE  A    
Sbjct: 1765 PLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQ----RKSSSKKSKKDKDELRA---- 1816

Query: 568  GRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASM-ELNESS 613
                     RR+ R     +N +  E+A   ++  + A M EL+ SS
Sbjct: 1817 --------QRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSS 1855



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 69/321 (21%), Positives = 105/321 (32%), Gaps = 72/321 (22%)

Query: 708  SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK-DTGQNGPKPPATLGADGPPPGPP 766
            SG +  +E+   +  +   + S   + P P   ++  D     P PP       PPP PP
Sbjct: 2363 SGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPP--PPPPPPPPP 2420

Query: 767  TPPPEDIPAPTEPTP----------ASEATGA---------------------------- 788
             PPP  +P PT P P          AS  T A                            
Sbjct: 2421 PPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICT 2480

Query: 789  PTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE----P 844
              PPP PP PS+ P  +    + E   + PP+        P   +L   T K  +    P
Sbjct: 2481 TAPPPVPPKPSSIPSGLVFTHRPE--PSKPPI-----APKPVIPQLPTTTQKPTDIHPKP 2533

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQ 896
                 T           D +    T+  +  + K      ++        T     G P 
Sbjct: 2534 TGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593

Query: 897  DSDSSATCSADEVDEAEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAA 954
            DS +S   ++  +    G     L+S  P  S++ P        + + P+  +Q    + 
Sbjct: 2594 DSSASQAITSWPL----GSPSKDLVSVEPVFSVVPPV------TAVEIPISSEQTFYISG 2643

Query: 955  AIPPIQVTKVHEPPREDAAPT 975
            A+     T V  P    AAPT
Sbjct: 2644 ALQTFSATPVTAPSSFQAAPT 2664



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%)

Query: 792  PPAPPSPSAPPPVVPKEEKEEETAAAPP---VEEGEEQKPPAAEELAVDTGK---AEEPV 845
            PPAP  P A P  VP E   ++TA  P    V++ E++    AE++ ++  K   + E +
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 846  KSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK--------EGGSGRATTAKSSGAPQD 897
                T + ++  +K +  +A+    +  L  EKK             +    +    P+D
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPED 1245

Query: 898  SDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIP 957
                        +E     K+ LL  +  +     + R   +P+   + KQ + +   +P
Sbjct: 1246 KKLLPEAKTSAPEE----QKHDLLKSQVQIAEEKLEGR--VAPKTVQEGKQPQTKMEGLP 1299

Query: 958  PIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPRGKSRSPAP 1011
                  +   P+ED   TK     P PP   +P+   P      ++   S    S+ P  
Sbjct: 1300 SGTPQSL---PKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356

Query: 1012 P 1012
            P
Sbjct: 1357 P 1357



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 93/443 (20%), Positives = 149/443 (33%), Gaps = 71/443 (16%)

Query: 770  PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPP 829
            PE + A       +   G+P+    P    A    + +EE+ +  A     +   +   P
Sbjct: 13   PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72

Query: 830  AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE---AAEATAEGALKAEKKEGGSGRA 886
             A   +    + +E   S   +++   P  G+ A+   +   T +     +K  G S   
Sbjct: 73   PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132

Query: 887  TTAKSSGAPQDSDSSATCS-----ADEVD--EAEGGDKNRLLSPRPSLLTPTGDPRANAS 939
             + K S +  D       S       EV+   A     N+  +P   +            
Sbjct: 133  ISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNK-FNPFDLISDSEASQEETTK 191

Query: 940  PQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP- 998
             QK +  +Q K      PP+Q     +PP+    P +  P   P  Q+  P+S + QQP 
Sbjct: 192  KQKVVQKEQGKPEGIIKPPLQ----QQPPK--PIPKQQGPGRDPLQQDGTPKSISSQQPE 245

Query: 999  ---------GSSPRGKSRSPAP-----PADKEAEKPVFFPAFAAEAQKL------PGDPP 1038
                     G   +G +++P       P  ++A +P    A     + +      P  PP
Sbjct: 246  KIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP 305

Query: 1039 CWTSGLPFP-VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-DTARPVLPRPPTISNP 1096
                  P P  PP +        P P+     P G   PL     T +P +  P T   P
Sbjct: 306  IQQ---PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPP 362

Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156
               +  AK P+   +Q G+           P SE                  PK LA   
Sbjct: 363  AQPLGPAKPPA---QQTGS---------EKPSSEQP---------------GPKALAQPP 395

Query: 1157 GVKQEQLSPRGQAGPP-ESLGVP 1178
            GV +      G A PP + +G P
Sbjct: 396  GVGKTPAQQPGPAKPPTQQVGTP 418



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 70/346 (20%), Positives = 112/346 (32%), Gaps = 57/346 (16%)

Query: 734  IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPP 793
            +  P    +       P    +L    PP  P  P  +D     +  P       PT   
Sbjct: 707  VKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDL 766

Query: 794  APPSPSAPPPVVP--KEEKEEETAAAPPVE----EGEEQKPPAAEELAVDTGKAEEPVKS 847
               S +   P +P  K + + E    PP++    +  +  PP  E+++    KA     S
Sbjct: 767  VSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS 826

Query: 848  ECTEEAEEGP---AKG--------KDAEAAEATAEGALKAEKKEGGSGRAT--------- 887
            +    +  GP   +KG        K  E  +A  + + K + K    G  T         
Sbjct: 827  DSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 888  ----TAKSSGAPQDSD---------------SSATCSADEVDEAEGGDKNRLLSPRPSLL 928
                T + S  PQ+                 S  T   + V     G    + S   +L+
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 929  TPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNL 988
            +  G P  ++       +KQ      A  P Q      PP+     T  APPAP     +
Sbjct: 947  STAGQPGPHSQSGPGAPMKQ------APAPSQPPTSQGPPKS----TGQAPPAPAKSIPV 996

Query: 989  QPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVF--FPAFAAEAQK 1032
            + E+ AP      P+ +        + E + P      +  AE QK
Sbjct: 997  KKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 78/369 (21%), Positives = 132/369 (35%), Gaps = 56/369 (15%)

Query: 509  QQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKED---LLKEKTDDTSGEDNDEKEAVA 565
            +QP P +    K    KE     E++K  V +DK     ++K  TD  S      K  + 
Sbjct: 721  KQP-PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIP 779

Query: 566  SKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKK 625
            S                      ++ +EE  TP    +  S + ++S   T E++     
Sbjct: 780  SS-------------------KVQSQAEEKTTPPLKTD--SAKPSQSFPPTGEKVSPFDS 818

Query: 626  GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685
              +    + S I    G  + S+ +      +K++      ++ + KM  + +A+   K 
Sbjct: 819  KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEP----KKAQTKMSPKPDAKPMPKG 874

Query: 686  APA------AASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT-------- 731
            +P        A +    P      + ++   S N   + +  ++      +T        
Sbjct: 875  SPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGF 934

Query: 732  -ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790
              SI S  +      GQ GP   +  GA       P+ PP     P       ++TG   
Sbjct: 935  GASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-------KSTGQAP 987

Query: 791  PPPAPPSPSAPPPVVPKEEK-EEETAAAPPVEEGE-EQKPPA---AEELAVDTGKAEEPV 845
            P PA   P       P  EK E +   AP V+  E E+KPP    ++ L  +  KA  P 
Sbjct: 988  PAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047

Query: 846  KSECTEEAE 854
            K E + + E
Sbjct: 1048 KLEKSPKPE 1056



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 112/542 (20%), Positives = 188/542 (34%), Gaps = 74/542 (13%)

Query: 487  YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLL 546
            + + G     +Q     Q    Q P P+S+ +      K    +KE + P  E  +    
Sbjct: 955  HSQSGPGAPMKQAPAPSQPPTSQGP-PKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--- 1010

Query: 547  KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606
            K +   T      EK+    K  K+  ++ ++    T+        E++  P+ +  L  
Sbjct: 1011 KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKL-------EKSPKPESTCPLCK 1063

Query: 607  MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFN---YKKRQNLD 663
             ELN  S+                              T ++CKN   N   +    +L 
Sbjct: 1064 TELNIGSKDPPN------------------------FNTCTECKNQVCNLCGFNPTPHLT 1099

Query: 664  EILQQHKLKMEKERNARRK----KKKAPAAASEEAAFPPVVEDEEMEASGV-------SG 712
            EI +   L  + +R    +    +K  PA +  +A+  PV  +   + + V         
Sbjct: 1100 EIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKK 1159

Query: 713  NEEEMVEEAEAT----VNNSSDTESIPSPHTEAAKDTGQNGPKPPAT-LGADGPPPGPPT 767
             E+E+  EAE      V  +   E IP   T   K       K  A+ L    P P    
Sbjct: 1160 QEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219

Query: 768  PPPEDIPAPTEPTPASEATGAPTPPPAPPSP----SAPPP---------VVPKEEKEEET 814
              PE+    +E          PTP      P    SAP           V   EEK E  
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279

Query: 815  AAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 874
             A   V+EG+ Q     E L   T ++      + T+  +E P     A+  +    G  
Sbjct: 1280 VAPKTVQEGK-QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP-DQVEPGKE 1337

Query: 875  KAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP 934
            K EK++  S  +++ +       SD+    S+D +  + G   + + +    +L      
Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGY--SSDGISSSLGEIPSLIPTDEKDILKGLKKD 1395

Query: 935  RAN--ASPQKPLDLKQLKQRAAAIPPIQV-TKVHEPPREDAAPTKPAPPAPPPPQNLQPE 991
              +  +SP  P DL +L+    +I   Q  T   E   +   P + +P  P   +  Q  
Sbjct: 1396 SFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL 1455

Query: 992  SD 993
            S+
Sbjct: 1456 SE 1457



 Score = 38.9 bits (89), Expect = 0.063
 Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 40/245 (16%)

Query: 1380 PSRDLTEAYKTQALGPLKLKPAHEGLVATV-----------KEAGRSIHEIPREELR--- 1425
            P +DL++A + +   PL  +P   G  +             K A      +P E+ +   
Sbjct: 690  PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPV 749

Query: 1426 --HTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHD-----VRSLIGSPGRTFPPV 1478
                P+ P   +P  +   +     K D  +S   S+  +     +++    P ++FPP 
Sbjct: 750  ADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT 809

Query: 1479 HPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHG 1538
                   D++A+ R   +  + S PG +S S G   +  PV   E  K  Q+ ++ +   
Sbjct: 810  GEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ-KQVDPVQKKEEPKKAQTKMSPK--- 865

Query: 1539 APFAGHLPRGSP------------VTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKS 1586
             P A  +P+GSP            V T + +P+ QE S   S       +T  P+    +
Sbjct: 866  -PDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFS--LNLGSITDAPKSQPTT 922

Query: 1587 PHSTV 1591
            P  TV
Sbjct: 923  PQETV 927



 Score = 38.5 bits (88), Expect = 0.082
 Identities = 100/473 (21%), Positives = 160/473 (33%), Gaps = 56/473 (11%)

Query: 1930 PKEAPRVARPERPRA-------DTGHAFLAKPPARSGLEPASS--PSKGSEPRPLVPPVS 1980
            P EA  +++P  P+        D       KP     ++P +    S  +  +P +P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 1981 GHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQSKPFSIQELELRSLGYHGSSY 2039
              +         L    A P    PP      P   K   +P S  ++ +   G    S 
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI-ISHPGPSSESK 841

Query: 2040 SPEGVEPVSPVSSPSLTHDKGLPK-HLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLR 2098
              + V+PV     P     K  PK   + + K        P  PGP    G+    P   
Sbjct: 842  GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGS------PTPPGPRPTAGQTVPTPQQS 895

Query: 2099 PLPESQPSSSPL----LQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL 2154
            P P+ Q     L    +  AP  +      T+   +       +++      +A  P P 
Sbjct: 896  PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGP- 954

Query: 2155 YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE 2214
            +S  G   P+     P      PP   G P         G+  P P K+  +       E
Sbjct: 955  HSQSGPGAPMKQAPAPSQ----PPTSQGPP------KSTGQAPPAPAKSIPVKK-----E 999

Query: 2215 PVSPPEGMTEPGHSRSAVYPLLYR-DGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAM 2273
              +P     EP   ++   P + R + E+  P    SKS     Q     +KL +S    
Sbjct: 1000 TKAPAAEKLEP---KAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKP- 1055

Query: 2274 VKSKKQEINKKLNTHNRNEPEYN-ISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMG 2332
             +S       +LN  +++ P +N  ++   ++ N+     T  +T     +QE    N  
Sbjct: 1056 -ESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLT----EIQEWLCLNCQ 1110

Query: 2333 LEAIIRKALMGGGGKAKVSGRPSSRKAK-SPAPGLASGDR---PPSVSSVHSE 2381
             +  I   L   G   K+   PS  KA   P P  +S  +   PP V  V  +
Sbjct: 1111 TQRAISGQL---GDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160



 Score = 35.8 bits (81), Expect = 0.53
 Identities = 32/139 (23%), Positives = 47/139 (33%), Gaps = 13/139 (9%)

Query: 726  NNSSDTESIPSPHTEA----------AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA 775
            +N   T   P PH+++          A         PP + G   P P    P  ++  A
Sbjct: 943  SNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA 1002

Query: 776  PTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELA 835
            P       +A  APT          PP    K    E   A  P +  +  KP +   L 
Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062

Query: 836  ---VDTGKAEEPVKSECTE 851
               ++ G  + P  + CTE
Sbjct: 1063 KTELNIGSKDPPNFNTCTE 1081



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 14/37 (37%), Positives = 30/37 (81%), Gaps = 3/37 (8%)

Query: 167  LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEE 203
            +++ +++Q+   +DRE+ +VE++ +KL+KKQ +L+EE
Sbjct: 3757 MARAKILQD---IDRELDLVERESAKLRKKQAELDEE 3790


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 129/555 (23%), Positives = 199/555 (35%), Gaps = 71/555 (12%)

Query: 683   KKKAPAAASEEAAFPPVVEDEEMEAS--------GVSGNEEEMVEEAEATVNNSSDTESI 734
             +KK P    ++   PP    E  +A+         +    E    E           + +
Sbjct: 10535 EKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKV 10594

Query: 735   PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA 794
             P+   +  + T    P+ P  +  +   P PP   PE  P      P         P   
Sbjct: 10595 PAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAI 10654

Query: 795   PPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK--AEEPVKSECTEE 852
             PP P +PPP V  EE EE     PP E  EE +P A  ++ V   K   E+   +   ++
Sbjct: 10655 PPKPESPPPEV-FEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKK 10713

Query: 853   AEEGPAKGKDA--EAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910
              E  P K  +   E         +  +K E    +         P+     A     EV 
Sbjct: 10714 PELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPE--KKVAVPKKPEVP 10771

Query: 911   EAEGGD--KNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPP 968
              A+  +  K  +L  +P++  P    RA + P +  +  +       I P +   V  P 
Sbjct: 10772 PAKVPEVPKKPVLEEKPAVPVP---ERAESPPPEVYEEPEEIAPEEEIAPEEEKPV--PV 10826

Query: 969   REDAAPTKPAPPAPPPPQNL----------QPESDAPQQPG-----SSPRGKSRSPAPP- 1012
              E+  P  P P  P  P+ +          +PE+  P++P        P+ K R P PP 
Sbjct: 10827 AEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPP 10886

Query: 1013  -ADKEAEKPVFFPAFAAEAQKLPGDP--PCWTSGLPFPVP--PREVIKASP-HAPDP--- 1063
                KE  K   F   A   +K+P  P  P      P  VP   ++V K  P   P+P   
Sbjct: 10887 APPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEE 10946

Query: 1064  ----SAFSYAPPGHP---LPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVL--ERQIG 1114
                 S     P        P  L    +P +P PP    PP  +   + P+V   ER+I 
Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPP----PPKPVEEVEVPTVTKRERKIP 11002

Query: 1115  AISQGMSVQ--LHVPYSEHAKAPVGPVTMGLPLPMDPKK-------LAPFSGVKQEQLSP 1165
               ++   ++  + +P  E    P   V    P P++P+          P  G K E  +P
Sbjct: 11003 EPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAP 11062

Query: 1166  RGQAGPPES--LGVP 1178
             + +A  P+    GVP
Sbjct: 11063 KEEAAKPKGPIKGVP 11077



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 143/691 (20%), Positives = 240/691 (34%), Gaps = 104/691 (15%)

Query: 507   QQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVAS 566
             ++++ +P    EE +E E   E E  EE P +E + E++   +  +        K+AV  
Sbjct: 10228 KEEEVLPVEVTEEPEE-EPISEEEIPEEPPSIE-EVEEVAPPRVPEVI------KKAVPE 10279

Query: 567   KGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNE-SSRWTEEEMETAKK 625
                           ++++ +  E    +   P Q  E    ++ E   +  E+++   KK
Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEE----KVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKK 10335

Query: 626   GLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKK 685
               +   +  + +   V              +++   + E L+   ++ E E     ++  
Sbjct: 10336 EAVPPAKGRTVLEEKVSVA-----------FRQEVVVKERLELEVVEAEVEEIPEEEEFH 10384

Query: 686   APAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVN--NSSDTESIPSPHTEAAK 743
                   EE  F  V E  ++E   V   EE  VE+    +    + + E    P      
Sbjct: 10385 EVEEYFEEGEFHEVEEFIKLEQHRVE--EEHRVEKVHRVIEVFEAEEVEVFEKPKAP--- 10439

Query: 744   DTGQNGPKPPATLGADGPPPGPPTP------PPEDIPAPTEPTPASEATGAPTPPPAPPS 797
                   PK P       PP  PPT       PP  +P   +     E    P  P  PP+
Sbjct: 10440 ------PKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPT 10493

Query: 798   PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP 857
                P  + PKE   E+    PP ++ E   P   E       + + PV     ++ E  P
Sbjct: 10494 -KVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPP--KKPEVPP 10550

Query: 858   AKGKDAEAAEATAEGALKA--EKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGG 915
              K  +   A    +   +A   K E        A     P+    +A     EV   +  
Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVP 10610

Query: 916   DKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPI---QVTKVHEPPREDA 972
             +  + + P   +  P         P+KP            +PP    +V KV  P ++  
Sbjct: 10611 EAPKEVVPEKKVPVPP--------PKKP-----------EVPPTKVPEVPKVAVPEKKVP 10651

Query: 973   APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP-ADKEAEKPVFFPAFAAEAQ 1031
                 P P +PPP    +PE  A ++P +    +    APP      +KPV      A   
Sbjct: 10652 EAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVA 10711

Query: 1032  KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPP 1091
             K P  PP     +  P  P+EV+                P   +PL        V+P+ P
Sbjct: 10712 KKPELPP-----VKVPEVPKEVV----------------PEKKVPL--------VVPKKP 10742

Query: 1092  TISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKK 1151
                 PP  +       V E+++    +       VP  E  K PV      +P+P   + 
Sbjct: 10743 EA--PPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVP--EVPKKPVLEEKPAVPVPERAES 10798

Query: 1152  LAPFSGVKQEQLSPRGQAGPPESLGVPTAQE 1182
               P    + E+++P  +  P E   VP A+E
Sbjct: 10799 PPPEVYEEPEEIAPEEEIAPEEEKPVPVAEE 10829



 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 123/530 (23%), Positives = 190/530 (35%), Gaps = 63/530 (11%)

Query: 653   YFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSG 712
             YF   +   ++E ++  + ++E+E    +  +      +EE     V E  +    G   
Sbjct: 10389 YFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVE---VFEKPKAPPKGPEI 10445

Query: 713   NEEEMVEEAEAT--VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPP 770
             +E+ +  +   T  V        +P    +   +     P+ P           PPT  P
Sbjct: 10446 SEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRV---------PPTKVP 10496

Query: 771   EDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKE---EETAAAPPVEEGE--E 825
             E +P P E  P  +      P P    P APPP VP+  KE   E+    PP ++ E   
Sbjct: 10497 EVLP-PKEVVPEKKV-----PVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPP 10550

Query: 826   QKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 885
              K P   + AV   K  E +  +      E P   K  E        A   +K E    +
Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPK--EVVPEKKVPAAPPKKPEVTPVK 10608

Query: 886   ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 945
                A     P+           EV   +  +  ++  P   +  P   P    SP  P  
Sbjct: 10609 VPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKV--PEAIPPKPESP-PPEV 10665

Query: 946   LKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR-G 1004
              ++ ++ A   PP +V  V EP  E AAP    P    PP+   PE  AP      P   
Sbjct: 10666 FEEPEEVALEEPPAEV--VEEP--EPAAP----PQVTVPPKKPVPEKKAPAVVAKKPELP 10717

Query: 1005  KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPD-P 1063
               + P  P +   EK V          K P  PP     +P  V P + + A P  P+ P
Sbjct: 10718 PVKVPEVPKEVVPEKKV-----PLVVPKKPEAPPAKVPEVPKEVVPEKKV-AVPKKPEVP 10771

Query: 1064  SAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQ 1123
              A     P  P+        +P +P P    +PPP +         E +I         +
Sbjct: 10772 PAKVPEVPKKPVL-----EEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAP-----EEE 10821

Query: 1124  LHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPE 1173
               VP +E  +  V P      +P +PKK+ P    K+  +  + +A PP+
Sbjct: 10822 KPVPVAEEEEPEVPPPA----VPEEPKKIIP---EKKVPVIKKPEAPPPK 10864



 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 122/522 (23%), Positives = 176/522 (33%), Gaps = 95/522 (18%)

Query: 692   EEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPK 751
             EE   PP    E +         +E+V E +  V  +   E+ P    EA K+       
Sbjct: 10486 EEPRVPPTKVPEVLPP-------KEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKV 10538

Query: 752   PPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEK- 810
             P        PPP  P  PP  +P      P +       P   PP P +PPP VP+  K 
Sbjct: 10539 PV-------PPPKKPEVPPTKVPE----VPKAAVPEKKVPEAIPPKPESPPPEVPEAPKE 10587

Query: 811   ---EEETAAAPPVE-EGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 866
                E++  AAPP + E    K P A +  V   K   P   +      + P   K A   
Sbjct: 10588 VVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPE 10647

Query: 867   EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926
             +   E      K E             A ++        A+ V+E E             
Sbjct: 10648 KKVPEAI--PPKPESPPPEVFEEPEEVALEEP------PAEVVEEPE------------- 10686

Query: 927   LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQ 986
                P   P+    P+KP+  K+     A  P +   KV E P+E   P K  P       
Sbjct: 10687 ---PAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKE-VVPEKKVPLV----- 10737

Query: 987   NLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPF 1046
                     P++P + P   ++ P  P +   EK V  P       K P  PP        
Sbjct: 10738 -------VPKKPEAPP---AKVPEVPKEVVPEKKVAVP-------KKPEVPPAKVP---- 10776

Query: 1047  PVPPREVIKASPHAPDPSAFSYAPP---GHPLPLGLHDTARPVLPRPPTISN------PP 1097
              VP + V++  P  P P      PP     P  +   +   P   +P  ++       PP
Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP 10836

Query: 1098  PLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSG 1157
             P +       + E+++  I +  +     P  E     V       P P  P    P   
Sbjct: 10837 PAVPEEPKKIIPEKKVPVIKKPEA----PPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED 10892

Query: 1158  VKQE--QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGG 1197
             VK++  QL    +   PE   VP   E + L+      VPGG
Sbjct: 10893 VKEKIFQLKAIPKKKVPEKPQVPEKVELTPLK------VPGG 10928



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 128/633 (20%), Positives = 231/633 (36%), Gaps = 88/633 (13%)

Query: 470   YYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA 529
             Y  T++ + Y+    R Y R         ++ ++   + ++P+P     E+    K K  
Sbjct: 9759  YEPTEEYDQYEEYEEREYER--------YEEHEEYITEPEKPIPVKPVPEEPVPTKPKAP 9810

Query: 530   EKEEEKPEVENDKEDL-LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMAN 588
               +  K  V  +K  + + +K      +  +E + V  +  + + ++ R K ++T   A 
Sbjct: 9811  PAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITK-REKEQVTEPAAK 9869

Query: 589   EANSEEAITPQQSAELASMELNESSRWTE--EEMETAKKGLLEHGRNWSAIARMVGSKTV 646
                  + +  ++   +   E+    R  E  +E+E  +    E       +   V    V
Sbjct: 9870  VPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEE------VVTHVEEYLV 9923

Query: 647   SQCKNFYFNYKKRQNLDEILQQHKLKM----------EKERNARRKKKKAPAAASEEAAF 696
              + + +    ++    +E++    +K+          EK+     KKK+AP A   E   
Sbjct: 9924  EEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPK 9983

Query: 697   PP-------VVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNG 749
              P       + + E+   + V    ++ V E +  V      E+ P+   E  K      
Sbjct: 9984  KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEK 10043

Query: 750   PKP-PATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPV---V 805
               P PA    + PP   P  P + IP   +PTP  +   AP  PP  P    P PV   +
Sbjct: 10044 KVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAP--PPKVPKKREPVPVPVAL 10101

Query: 806   PKEEK---EEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862
             P+EE+   EEE      V   EE+  P  EE+  +  +     +    EE E  P +   
Sbjct: 10102 PQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYV 10161

Query: 863   AEAAEATAEGALKAEKKEGGSGRA--------TTAKSSGAPQDSDSSATCSADEVDEAEG 914
              E  E   E  +  E K      A         T K    P+  ++      +   + E 
Sbjct: 10162 PEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVE- 10220

Query: 915   GDKNRLLSPRPSLLTP---TGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED 971
               + R++ P+   + P   T +P      ++P+  +++ +     P I+  +   PPR  
Sbjct: 10221 --EKRIILPKEEEVLPVEVTEEPE-----EEPISEEEIPEEP---PSIEEVEEVAPPRVP 10270

Query: 972   AAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031
                 K  P AP P   +  + +AP    S    + + P P   KEA              
Sbjct: 10271 EVIKKAVPEAPTP---VPKKVEAPPAKVSKKIPEEKVPVPVQKKEA-------------- 10313

Query: 1032  KLPGDPPCWTSGLPFPVPPREVIKASPHAPDPS 1064
                  PP     +P  VP ++V+     A  P+
Sbjct: 10314 -----PPAKVPEVPKKVPEKKVLVPKKEAVPPA 10341



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 215/1079 (19%), Positives = 370/1079 (34%), Gaps = 162/1079 (15%)

Query: 434   EQEKETFREKFMQ-HPKNFGLIASF------LERKTVAECVLYYYLTKKNENYKSLVRRS 486
             ++EKE   EK    H +    I SF      LE +   E     Y  + +E+Y+ +  + 
Sbjct: 9049  QKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEI--KV 9106

Query: 487   YRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEA-EKEEEKPEVENDKEDL 545
               ++   ++ ++  ++ Q+  +++      +EE +E  +E+E  + ++E  E  ++++  
Sbjct: 9107  EAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVP 9166

Query: 546   LKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELA 605
              K             K+ V  K  KT+      K ++T+         + I PQ+ +   
Sbjct: 9167  AKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKV----PEVSKKIVPQKPSRTP 9222

Query: 606   SMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKN-------FYFNYKK 658
               E  E        + T K  + E    +++      S TV + +         +    K
Sbjct: 9223  VQE--EVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISK 9280

Query: 659   RQNLDEILQQHKLKMEKERNAR---RKKKKAPAAASEEAAFPPVVED---------EEME 706
             R      + +   K   E  A     KK + PA    E    PV E+         E   
Sbjct: 9281  RVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAA 9340

Query: 707   ASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP 766
                V    ++ V E +  V  +   E+ P+   E  K           T   + PPP  P
Sbjct: 9341  PPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVP 9400

Query: 767   TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQ 826
               P + +P   +P P  E    P PP  P  P  P P    EEK      A PV   ++ 
Sbjct: 9401  EIPKKKVPEERKPVPRKEEE-VPPPPKVPALPKKPVP----EEK-----VAVPVPVAKKA 9450

Query: 827   KPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALK-AEKKEGGSGR 885
              PP AE   V      E  +    E+      +  +    E +AE     +E++EG S  
Sbjct: 9451  PPPRAE---VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSIS 9507

Query: 886   ATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLD 945
                 +     ++++ +     +E +E    +K  ++S R                 +P +
Sbjct: 9508  VYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVE--------------AEPAE 9553

Query: 946   LKQLKQRAAAIPPIQVTKVHEPP--REDAAPTKPAP----PAPPPPQNLQPESDAPQQPG 999
             + + +++   + P    K+ EPP  +   AP K  P    PAP P +   P    P++P 
Sbjct: 9554  VTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPK 9613

Query: 1000  SSPRGKSRSPAPPADKEAEKPVFFPAFAAEA-QKLPGDPPCWTSGLPFPVPPREVIKASP 1058
                  K     PP   + E+P+  PA   E   ++  +     +      PP+  +   P
Sbjct: 9614  KPVPEKK---VPPKVIKMEEPL--PAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEP 9668

Query: 1059  H--APDPSAFSYAPPGHPLPLG--LHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIG 1114
                 P+       P     P         R V     +I  P       K  +++E +  
Sbjct: 9669  KRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKER 9728

Query: 1115  AIS---QGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQ----EQLSPRG 1167
             A +   + +SVQ    Y E+ +              D K+   +   ++    E+   R 
Sbjct: 9729  AYTLEEEAVSVQREEEYEEYEE-------------YDYKEFEEYEPTEEYDQYEEYEERE 9775

Query: 1168  QAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPAD 1227
                  E     T  E                  K IP   VP +   T         PA 
Sbjct: 9776  YERYEEHEEYITEPE------------------KPIPVKPVPEEPVPTK----PKAPPAK 9813

Query: 1228  VLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRS 1287
             VL K      +    P +L        P   V  E KK  V   +  +S+T+  KE    
Sbjct: 9814  VLKKAVPEEKVPVPIPKKL------KPPPPKVPEEPKK--VFEEKIRISITKREKE---- 9861

Query: 1288  SSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPER--HSPHHLK-EQHHIRG 1344
                   +   P     M   RV   ++   +        PP R    P  L+ E+     
Sbjct: 9862  ------QVTEPAAKVPMKPKRV---VAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEE 9912

Query: 1345  SITQGIPRSYVEAQEDYLRREAKLLKREGTPP------PPPPSRDLTEAYKTQALGPLKL 1398
              +   +    VE +E+Y+  E + +  E   P      P  P + + E  K     P+ +
Sbjct: 9913  EVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKK-----PVPV 9967

Query: 1399  KPAHEGLVATVKEAGRSIHE-----IPREELRHTPELPLAP-RPLKEGSITQGTPLKYD 1451
                 E   A V E  +   E     IP++E     ++P  P +P+ E  +    P K +
Sbjct: 9968  PKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVE 10026



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 205/1021 (20%), Positives = 338/1021 (33%), Gaps = 158/1021 (15%)

Query: 670   KLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSS 729
             K K+ +++    KK++AP A   E   P  VE++ +    +   EEE++      V  + 
Sbjct: 10191 KKKVTEKKVVIPKKEEAPPAKVPEV--PKKVEEKRI----ILPKEEEVLP-----VEVTE 10239

Query: 730   DTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAP 789
             + E  P    E                    P   P     E++  P  P    +A    
Sbjct: 10240 EPEEEPISEEEI-------------------PEEPPSIEEVEEVAPPRVPEVIKKAV-PE 10279

Query: 790   TPPPAPPSPSAPPPVVPKEEKEEETAA------APPVEEGEEQKPPAAEELAVDTGKAEE 843
              P P P    APP  V K+  EE+         APP +  E  K    +++ V   +A  
Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVP 10339

Query: 844   PVKSECTEEAEEGPAKGKDAEAAEATAEGALKAE----KKEGGSGRATTAKSSGAPQDSD 899
             P K     E +   A  ++    E      ++AE     +E            G   + +
Sbjct: 10340 PAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVE 10399

Query: 900   SSATCSADEVDEAEGGDK-NRLLSPRPS-----LLTPTGDPRANASPQKPLDLKQLKQRA 953
                      V+E    +K +R++    +        P   P+     +K +  K+     
Sbjct: 10400 EFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKK----- 10454

Query: 954   AAIPPIQVTKVHEPP-------------REDAAPTKPAPPAPPPPQNLQPESDAPQQPGS 1000
                PP +V    EPP              +   P +P  P    P+ L P+   P++   
Sbjct: 10455 ---PPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVP 10511

Query: 1001  SPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS-PH 1059
              P  K     PP   EA K V         +K+P  PP      P  VP  EV KA+ P 
Sbjct: 10512 VPPAKKPEAPPPKVPEAPKEV------VPEKKVPVPPPKKPEVPPTKVP--EVPKAAVPE 10563

Query: 1060  APDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQG 1119
                P A    P   P    + +  + V+P     + PP      K P V   ++    + 
Sbjct: 10564 KKVPEAIPPKPESPPPE--VPEAPKEVVPEKKVPAAPP------KKPEVTPVKVPEAPKE 10615

Query: 1120  MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVP- 1178
             +  +  VP     K  V P      +P  PK   P   V  E + P+ ++ PPE    P 
Sbjct: 10616 VVPEKKVPVPPPKKPEVPPT----KVPEVPKVAVPEKKV-PEAIPPKPESPPPEVFEEPE 10670

Query: 1179  ----TAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSI----THGTPADVLY 1230
                     A V+      + P  ++    P     + + +  +  +        P +V+ 
Sbjct: 10671 EVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVP 10730

Query: 1231  KGTITRII---GEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRS 1287
             +  +  ++    E  P+++    ++ +P+  V    KK  V   +      +   E+  +
Sbjct: 10731 EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVP-KKPEVPPAKVPEVPKKPVLEEKPA 10789

Query: 1288  SSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSIT 1347
                P    + P   Y+  E            E      I PE   P  + E+        
Sbjct: 10790 VPVPERAESPPPEVYEEPE------------EIAPEEEIAPEEEKPVPVAEEEE------ 10831

Query: 1348  QGIPRSYVEAQEDYLRREAK--LLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGL 1405
               +P   V  +   +  E K  ++K+   PPP  P  +  +  +   L P    P     
Sbjct: 10832 PEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPE--KVIEKPKLKPRPPPPPPAPP 10889

Query: 1406  VATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDTGASTT-------- 1457
                VKE    +  IP++++   P++P            + TPLK   G            
Sbjct: 10890 KEDVKEKIFQLKAIPKKKVPEKPQVP---------EKVELTPLKVPGGEKKVRKLLPERK 10940

Query: 1458  GSKKHDV--RSLIGS-PGRTFPPVHPLDVMADARALERACYEESLKSRP------GTASS 1508
                K +V  +S++   P    P V P  +      +++    E    +P       T + 
Sbjct: 10941 PEPKEEVVLKSVLRKRPEEEEPKVEPKKL----EKVKKPAVPEPPPPKPVEEVEVPTVTK 10996

Query: 1509  SGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSS 1568
                 I    P  VPE+ KP       E    P A       P    EPTP     ++   
Sbjct: 10997 RERKIPE--PTKVPEI-KPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVV 11053

Query: 1569  KASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSI 1628
                 + K         K P   VP+  P PI      LR  SG +      P  +   ++
Sbjct: 11054 GKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAV 11113

Query: 1629  P 1629
             P
Sbjct: 11114 P 11114



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 150/764 (19%), Positives = 262/764 (34%), Gaps = 145/764 (18%)

Query: 507  QQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEA--V 564
            ++++P P+  +  K  K  +K+A+K   KP+    +E+++K+    T+       E   V
Sbjct: 8973 EEKKPPPKRIEVTK--KAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDV 9030

Query: 565  ASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAK 624
            +SK  +       RK  + +        ++A+  ++   + S E        E   E  +
Sbjct: 9031 SSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFE 9090

Query: 625  KGLLEHGRNWSAIARMVGSKTVSQCKNFYFN-----YKKRQNLDE--------ILQQHKL 671
            +   E         ++   K V +     F      Y++ +  DE          ++  +
Sbjct: 9091 QPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVI 9150

Query: 672  KMEKERNARRKKKKAPAAASEEAAFPPV-----------------VEDEEMEASGV---- 710
            +++KE      ++K PA   E+ A PP                  +E+E+++ + V    
Sbjct: 9151 QVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVS 9210

Query: 711  ----------SGNEEEMVEEAEATVNNS----SDTESIPSPHTE---------------- 740
                      +  +EE++E     V+      S+ +   + HTE                
Sbjct: 9211 KKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVT 9270

Query: 741  ------AAKDTGQNGPKPPATLGADGPPPGPPTPPPEDI--PAPTEP-TPASEATGAPTP 791
                  A     +  PK P       P    P P P+ +  PAP  P  P         P
Sbjct: 9271 EEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKP 9330

Query: 792  PPAPPSPSAPPPVVPK-------EEKEEETAA----APPVEEGEEQKPPAAEE-LAVDTG 839
             P P    A PP VP+       EEK     A    APP +  E QK    EE + + T 
Sbjct: 9331 VPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQ 9390

Query: 840  KAEEP-------VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSS 892
            + E P        K +  EE +  P K ++            K   +E  +     AK +
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKA 9450

Query: 893  GAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQR 952
              P+   S  T     V+E     + +L    P  +  T   R   S ++     + ++ 
Sbjct: 9451 PPPRAEVSKKTV----VEEKRFVAEEKLSFAVPQRVEVT---RHEVSAEEEWSYSEEEEG 9503

Query: 953  AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPP 1012
             +    I V +  E   E+ A          P + +  E     +     +     PA  
Sbjct: 9504 VS----ISVYREEEREEEEEAEVTEYEVMEEPEEYVVEE-----KLHIISKRVEAEPAEV 9554

Query: 1013 ADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPG 1072
             +++ +K V  P   A   K+   PP      P  + P + +     AP P      PP 
Sbjct: 9555 TERQEKKIVLKPKIPA---KIEEPPPAKVPEAPKKIVPEKKVP----APVPKKEKVPPPK 9607

Query: 1073 HPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHA 1132
             P      +  +PV    P    PP +I        +E  + A       + H+  ++  
Sbjct: 9608 VP-----EEPKKPV----PEKKVPPKVIK-------MEEPLPA----KVTERHMQITQEE 9647

Query: 1133 KAPVGPVTMGLP----LPMDPKKLAPFSGVKQEQLSPRGQAGPP 1172
            K  V       P    +P +PK+  P    K  +L P+ +  PP
Sbjct: 9648 KVLVAVTKKEAPPKARVPEEPKRAVPEE--KVLKLKPKREEEPP 9689



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 66/268 (24%), Positives = 91/268 (33%), Gaps = 47/268 (17%)

Query: 1919  VYPTLMEPVLLPKEA--------PRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGS 1970
             V PT +  VL PKE         P   +PE P      A     P +    P   P K  
Sbjct: 10490 VPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKK--VPVPPPKKPE 10547

Query: 1971  EPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELR 2030
              P   VP V   A   +   + + P   SP P  P A       +K  + P    E+   
Sbjct: 10548 VPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPV 10607

Query: 2031  SLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGE 2090
              +        PE   PV P   P +      P  + E+          PK   P K   E
Sbjct: 10608 KVPEAPKEVVPEKKVPVPPPKKPEVP-----PTKVPEV----------PKVAVPEKKVPE 10652

Query: 2091  AAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPL 2150
             A     + P PES P         P V      V L +  +EV+ ++     P Q++ P 
Sbjct: 10653 A-----IPPKPESPP---------PEVFEEPEEVALEEPPAEVV-EEPEPAAPPQVTVPP 10697

Query: 2151  PAPLYSFPGASCPVLDLRRPPSDLYLPP 2178
               P+   P    P +  ++P     LPP
Sbjct: 10698 KKPV---PEKKAPAVVAKKPE----LPP 10718



 Score = 38.5 bits (88), Expect = 0.082
 Identities = 43/166 (25%), Positives = 61/166 (36%), Gaps = 25/166 (15%)

Query: 667   QQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVN 726
             ++ + K+E ++  + KK   P         PP    EE+E   V+  E ++ E  +  V 
Sbjct: 10958 EEEEPKVEPKKLEKVKKPAVPEP-------PPPKPVEEVEVPTVTKRERKIPEPTK--VP 11008

Query: 727   NSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEAT 786
                    +P+P  +         PKP A +    PPP    P P  I AP       +  
Sbjct: 11009 EIKPAIPLPAPEPK---------PKPEAEVKTIKPPP--VEPEPTPIAAPVTVPVVGKKA 11057

Query: 787   GAPTPPPAPPSPSAPPPVVPKEEK---EEETAAAPPVEEGEEQKPP 829
              A  P      P  P   VPK+     E E     P   GE  KPP
Sbjct: 11058 EAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGE--KPP 11101



 Score = 35.4 bits (80), Expect = 0.70
 Identities = 152/754 (20%), Positives = 240/754 (31%), Gaps = 172/754 (22%)

Query: 761  PPPGPPTPPPEDIPA---------------PTEPTPASEATGAPTPPPAPPSPSAPPPVV 805
            P P    PPP+ I                 P E TP  E    P PPP    P+  P ++
Sbjct: 8970 PTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKP-PPPTTLIPAKAPEII 9028

Query: 806  PKEEKEEETAAAPPVEEGEEQKPPAA-----------------------EELAVD--TGK 840
                K EE        + E QK   A                       +EL V+  T  
Sbjct: 9029 DVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEP 9088

Query: 841  AEEPVKSECTEEAEEGPAKGK---DAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQD 897
             E+P   E  E+ EE   + K     E  E   EG    E++EG           G  + 
Sbjct: 9089 FEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEG--------YDEGEEEW 9140

Query: 898  SDSSATCSADEVDEA--EGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAA 955
             ++       +V +   E   + ++ +  P    P   P      +  ++  +   R   
Sbjct: 9141 EEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAP---PPPKVIKKPVIEKIEKTSRRME 9197

Query: 956  IPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADK 1015
               +QVTKV E  ++      P  P+  P Q    E   P                 +  
Sbjct: 9198 EEKVQVTKVPEVSKK----IVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHT 9253

Query: 1016 EAEKPVFFPAFAAE---------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAF 1066
            E E  V  P    E         A     +PP     LP    P EV      AP P   
Sbjct: 9254 EEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEV------APVPIPK 9307

Query: 1067 SYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHV 1126
               PP   +         P +P+ P      P+    K P+   +              V
Sbjct: 9308 KVEPPAPKV---------PEVPKKPVPEEKKPVPVPKKEPAAPPK--------------V 9344

Query: 1127 PYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQ-----------LSPRGQAGPPESL 1175
            P  E  K PV      +P+P+  KK AP + V + Q           ++ R ++ PP   
Sbjct: 9345 P--EVPKKPVPEEK--IPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVP 9400

Query: 1176 GVPTAQEASVLRGTAL--GSVPGGSITKGIPSTRVPSDS-AITYRGSITHGTPADVLYKG 1232
             +P  +     +        VP       +P   VP +  A+    +     P   + K 
Sbjct: 9401 EIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKK 9460

Query: 1233 TIT---RIIGEDS-----PSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKED 1284
            T+    R + E+      P R++  R       H +   ++      E G+S++   +E+
Sbjct: 9461 TVVEEKRFVAEEKLSFAVPQRVEVTR-------HEVSAEEEWSYSEEEEGVSISVYREEE 9513

Query: 1285 GRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRG 1344
                     E  A    Y++ME                     PE +    ++E+ HI  
Sbjct: 9514 RE------EEEEAEVTEYEVME--------------------EPEEYV---VEEKLHIIS 9544

Query: 1345 SITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEG 1404
               +  P    E QE  +  + K+  +   PPP      + EA       P K+ P  + 
Sbjct: 9545 KRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPP----AKVPEA-------PKKIVPEKKV 9593

Query: 1405 LVATVKEAGRSIHEIPREELRHTPELPLAPRPLK 1438
                 K+      ++P E  +  PE  + P+ +K
Sbjct: 9594 PAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIK 9627



 Score = 32.7 bits (73), Expect = 4.5
 Identities = 45/214 (21%), Positives = 89/214 (41%), Gaps = 31/214 (14%)

Query: 60    QPQRRRPSLLSEFQ-PGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLL 118
             +P+ + P L+ + + P   +  E+  +P     +P     ++E   +K P +   P P  
Sbjct: 9984  KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEK 10043

Query: 119   R---PSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPS-----PPHTDPELELVP-----P 165
             +   P+P      PA   ++ K + +  + +P   P      PP    + E VP     P
Sbjct: 10044 KVPVPAPKKVEAPPAKVPEVPK-KLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALP 10102

Query: 166   R----LSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIES 221
             +    L +EE++   + +  E  ++ ++   L ++++ L EE   PPE E+    PP E 
Sbjct: 10103 QEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEE---VPPEEE 10159

Query: 222   KHRSLVQIIYDENRKKAEAAHRILEGLGPQVELP 255
                      Y    ++      +L  + P+V +P
Sbjct: 10160 ---------YVPEEEEFVPEEEVLPEVKPKVPVP 10184


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 103/543 (18%), Positives = 229/543 (42%), Gaps = 45/543 (8%)

Query: 166 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRS 225
           R  +E++ +  +R+  +   + +Q  K+ +++++L E+  +  E EK +       +   
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEE 348

Query: 226 LVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMR----KKLI 281
            +Q   ++  ++ E      E +  Q E  L+ Q    R+  + ++  +       ++L 
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEER-LWEQEKQMREQEQKMRDQEERMWEQDERLR 407

Query: 282 LYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIR 341
              +R     K WEQ    R ++ M+  EKK    E    +  +E ++RE  +K   E  
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEE 464

Query: 342 KQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYD 401
             RE +E+MQ +  +            +  + E  + L EQE +++Q  ++         
Sbjct: 465 TMREQEEKMQKQ--EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-------- 514

Query: 402 ADQQRIKFINMNGLMADPMKVYKDRQVMN----MWSEQEKETFREKFMQHPKNFGLIASF 457
             +Q  K  +   +     K+++  ++      MW ++EK   +E+ M   +        
Sbjct: 515 --EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER------ 566

Query: 458 LERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQ---QQQQQQQQQQQQQQQQPMPR 514
           +E+KT  +    +   +K    + +  R  + R + +   +Q+++ Q+Q+++ Q+Q    
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626

Query: 515 SSQEEKDEKEKEKEAEKEE----------EKPEVENDKEDLLK-EKTDDTSGEDNDEKEA 563
             QEEK ++++EK  E+EE          E+  +   KE L + EK  +       E++ 
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686

Query: 564 VASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETA 623
              +  +    +  +K      M  E +  E     +  E    E  E  +  EE+M+  
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746

Query: 624 KKGLLE-HGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRK 682
           ++ + E   + W    +M   + + + K   + ++K Q  ++I +Q +   ++E   R +
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806

Query: 683 KKK 685
           ++K
Sbjct: 807 EEK 809



 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 113/591 (19%), Positives = 245/591 (41%), Gaps = 79/591 (13%)

Query: 170 EELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQI 229
           EEL +  D +  E+        +LKKK  +L+E+              P+    +S +Q+
Sbjct: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKL-------------PLAESEKSEIQL 246

Query: 230 IYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAMRKKLILYF 284
              E ++K E A  +L    PQV+       ++ Q  + R+  + I              
Sbjct: 247 NVKELKRKLERAKFLL----PQVQTNTLQEEMWRQEEELREQEKKI-------------- 288

Query: 285 KRRNHARKQWEQKFCQRYDQ-LMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQ 343
             R    K W Q+   R  +  M   E+K+ R E   R + KE + +E   ++  E+R+Q
Sbjct: 289 --RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQ 346

Query: 344 RELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDAD 403
            E  +  + ++ ++   +     +   +   + +   +    E++MR        +++ D
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ---EERMWEQD 403

Query: 404 QQ-RIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKT 462
           ++ R K   M        +V K R+   M  +++K   +E+ MQ  +        +  + 
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463

Query: 463 VAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDE 522
                    + K+ EN      + ++++   +Q+++  +Q++ Q+Q++ +    ++ +D+
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523

Query: 523 KE----------KEKEAEKEEEKPEVEN----------DKEDLLKEKTDDTSGEDNDEKE 562
           +E          +EK  E+E++  E E           D+E+ +++KT +   +  D++E
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583

Query: 563 AVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEE--M 620
            +  + R     +  +K R    M  E   EE +  Q+      M+  E   W +EE   
Sbjct: 584 KMREEERM---REREKKMREEEEMMRE--QEEKMQEQEE----KMQEQEEKMWEQEEKMQ 634

Query: 621 ETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNAR 680
           E  +K   +  + W    +M   + + + K   + ++K Q  +++ +Q +   E+E+  +
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694

Query: 681 RKKKKAPAAASEEAAFPPVVEDEEM-EASGVSGNEEEMVEEAEATVNNSSD 730
           + +++      +E     + E+E M E       EEEM+ E E  +    +
Sbjct: 695 KTQEQEKKTWDQE----KMREEESMREREKKMREEEEMMREQEEKMQEQEE 741



 Score = 72.4 bits (176), Expect = 5e-12
 Identities = 94/480 (19%), Positives = 198/480 (41%), Gaps = 46/480 (9%)

Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228
           +E++ + ++++  E  M EQ+     ++++  EEE  +  E +       +  +   + +
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475

Query: 229 IIYDENRKKAEAAHRILEGLGPQVEL-----PLYNQPSDTRQYHENIKINQAM---RKKL 280
              +EN  + E      + L  Q E       +  Q     +  E I+  + M    KK+
Sbjct: 476 --QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533

Query: 281 ILYFKRRNHARKQWEQKFCQRYDQLMEAW-------------EKKV----ERIENNPRRR 323
               K R    + WEQ+   R DQ  + W             EKK     E++    R R
Sbjct: 534 WRQEKMREQEDQMWEQEEKMR-DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR 592

Query: 324 AKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQE 383
            +E K+RE  E    +  K +E +E+MQ +  +            E ++ E  + + EQE
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQE 651

Query: 384 NLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREK 443
               + ++L      L++ ++ +        +     K+++  ++     EQEK+T+ ++
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQ----EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707

Query: 444 FMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQ 503
            M+  ++        E+K   E  +     +K +  +  ++       + +++  +Q+++
Sbjct: 708 KMREEESM----REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763

Query: 504 QQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGED---NDE 560
             +QQ+ P     +E+  E EK +E EK  E+ E   D+E+ ++ + +   G++     +
Sbjct: 764 MWEQQRLP---EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820

Query: 561 KEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEM 620
           +E +  +  K    + +  G+  +    E   EE +   Q  E    E  E  R  EE+M
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKM---QGQEEKMREQEEKMRGQEEKM 877



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 84/448 (18%), Positives = 188/448 (41%), Gaps = 64/448 (14%)

Query: 166 RLSKEELIQNMDRVDREI--TMVEQQISKLKKKQQQLEEEAAK-------PPEPEKPVSP 216
           ++ +EE I+  ++  RE   TM EQ+  K++K+++ + E+  K       P + EK    
Sbjct: 445 KMQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503

Query: 217 PPIESKHRSL---VQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKIN 273
             ++ +   +    + I D+     +      +    + E  ++ Q    R   + +   
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563

Query: 274 QAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAK-----ESK 328
           +   +K     K +   +K W+Q+   R ++ M   EKK+   E   R + +     E K
Sbjct: 564 EERMEK-----KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 618

Query: 329 VREYYEKQFPEIRKQRELQERM----------------QSRVGQRGSGLSMSAARSEHE- 371
           ++E  EK + +  K +E +E+M                Q R+ ++   L       E E 
Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678

Query: 372 VSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMN- 430
           + E  + + EQE +EK+ ++        +D ++ R +      +     K+ ++ ++M  
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREE----ESMREREKKMREEEEMMRE 731

Query: 431 ----MWSEQEK--ETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR 484
               M  ++EK  E   E + Q  K +       E++ + E     +  +K +  + +  
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791

Query: 485 RSYRRRGKSQQQQQQQQQQQQQQQQ----------QPMPRSSQEEKDEKEKEKEAEKEEE 534
           +  + R + ++ + Q+++ + Q+++          Q      QEEK   ++EK   +EE+
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851

Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKE 562
             E    +E+ ++E+ +   G++   +E
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMRE 879



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 69/368 (18%), Positives = 162/368 (44%), Gaps = 60/368 (16%)

Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQ 228
           +EE ++  +R+      + ++   +++++++++E+  K  E E+ +     E K +   +
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ--EEKMQEQEE 638

Query: 229 IIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRN 288
            ++++  K  E   ++ E    Q  LP   +  +    HE ++  + M+++         
Sbjct: 639 KMWEQEEKMWEQEEKMWE----QQRLP---EQKEKLWEHEKMQEQEKMQEQ--------- 682

Query: 289 HARKQWEQKFCQRYDQLME--AWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQREL 346
              K WEQ+  ++  Q  E   W+++  R E + R R  E K+RE  E    +  K +E 
Sbjct: 683 -EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER--EKKMREEEEMMREQEEKMQEQ 739

Query: 347 QERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQR 406
           +E+MQ +               E E+ E  + + EQE    + ++L      L++ ++  
Sbjct: 740 EEKMQEQ---------------EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-- 782

Query: 407 IKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAEC 466
                    M +  K+++  + M    ++EK   +E+ M+  +         E+    E 
Sbjct: 783 ---------MQEQEKIWEQEEKMR--DQEEKMRGQEEKMRGQE---------EKMRGQEE 822

Query: 467 VLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKE 526
            ++    K     + +  +  +  G+ ++ +++ Q Q+++ ++Q      QEEK  +++E
Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882

Query: 527 KEAEKEEE 534
           K   +EE+
Sbjct: 883 KMRGQEEK 890


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 124/491 (25%), Positives = 163/491 (33%), Gaps = 94/491 (19%)

Query: 762  PPGPPTPPPEDIPAPTEPTPASEAT-------------GAPTPPPAP---PSPSAPPPVV 805
            PPG P PPP   PA      A+ A              GA  P  AP   P+ ++ PP  
Sbjct: 29   PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS 88

Query: 806  PKEEK---EEETAAAP------------PVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 850
             + E+    + T+  P            P   G++    +AEE  V  GKA E  K    
Sbjct: 89   GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE-TVARGKATEAPKRSAL 147

Query: 851  EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVD 910
                     G              +A   E G  R   +     P +    +  SA E  
Sbjct: 148  SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 207

Query: 911  EAE-----------GGDKNR------------LLSPRPSLLTPTGDPRANASPQKPLDLK 947
              E           GG   R            L SP  S  +  G PRA A P +P    
Sbjct: 208  TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP---- 263

Query: 948  QLKQRAAAIPPIQVTKVHEPPREDAAP----------TKPAPPAPPPPQNLQPESDAPQQ 997
               +   A+ P QVT    PPR+DAAP            P+P APP P         P  
Sbjct: 264  -KPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP 318

Query: 998  PGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKAS 1057
            P + P   + S   P  +     +  P  +  A   P  PP         +PP +   + 
Sbjct: 319  PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA------LALPPLQAPPSP 372

Query: 1058 PHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRP-PTISNP------PPLISSAKHPSVLE 1110
            P +P  S  +   P  P  L +H    P  P P P +  P      PP+  SA  PS   
Sbjct: 373  PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 432

Query: 1111 RQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAG 1170
              + A        L VP S  A  P+ P     P    P    P    K    +P   A 
Sbjct: 433  PSLAA------PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486

Query: 1171 PP-ESLGVPTA 1180
            PP ++L  P A
Sbjct: 487  PPLQALPSPPA 497



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 118/536 (22%), Positives = 150/536 (27%), Gaps = 92/536 (17%)

Query: 683  KKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAA 742
            K  +P   S             +   G+  + EE V   +AT        S  +    + 
Sbjct: 98   KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG 157

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP 802
               G   P       A G   G P P P   P P    P    + A       PSP+A  
Sbjct: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA-- 215

Query: 803  PVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862
                                   ++P A        G  + P     +  A         
Sbjct: 216  ----------------------RRRPSAG-------GGLQRPASRSLSSSAT-------- 238

Query: 863  AEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 922
                       L +  + G S R T    +   Q                   D    L 
Sbjct: 239  ----------PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 288

Query: 923  PRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEP---------PREDAA 973
            P  S    T  P A  SP  P  L+ L    A  P    T +  P         P    +
Sbjct: 289  PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS 348

Query: 974  PTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKL 1033
            P    PP  PP   L P    P  P S P     +P+P A           A A    + 
Sbjct: 349  PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN---------ALAVHLLQA 399

Query: 1034 PGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTI 1093
            P  PP        P PP +    SP A  P + S  PP    P      A P L  PP+ 
Sbjct: 400  PFSPP--------PSPPVQA-PFSPPASPPVSPSATPPSQAPP----SLAAPPLQVPPSP 446

Query: 1094 SNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLA 1153
               PP+  SA  P      + A      +QL  P  +   A   P    LP P       
Sbjct: 447  PASPPMSPSATPPPQAPPPLAA----PPLQLAKPPPQAPPALATPPLQALPSP------- 495

Query: 1154 PFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVP 1209
            P S   Q   SP     P   L  P  Q   VL    L   P    +  + + R P
Sbjct: 496  PASFPGQAPFSPSASL-PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP 550



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 94/388 (24%), Positives = 137/388 (35%), Gaps = 57/388 (14%)

Query: 734  IPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAP--TEPTPASEATGAPT- 790
            +  P  +AA   G     P AT     PP     P  + +P+P  T P+ A+ + G+PT 
Sbjct: 276  VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335

Query: 791  ---------PPPAP---PSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVD 837
                     PP +P   P P APP + +P  +      A+PP+       P A   LAV 
Sbjct: 336  QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395

Query: 838  TGKA------EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTA 889
              +A        PV++  +  A     P+    ++A  + A   L+       S  A+  
Sbjct: 396  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPP 451

Query: 890  KSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-----RANASPQKPL 944
             S  A     +    +A  +  A+   +       P L      P     +A  SP   L
Sbjct: 452  MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 511

Query: 945  DLKQLKQRAAAIPPIQVTKVHE-PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 1003
             +  L       PP+    + + PP   A+PT  AP  PP P         P    S PR
Sbjct: 512  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP--------GPDTSVSGPR 563

Query: 1004 ---GKSRSPAPPADKEAEKPVFFPAFA---AEAQKLPGDPPCWTSG-----LPFPVPPRE 1052
                 +  P PP  +     +  P  A   + A   P +   + SG        P P  E
Sbjct: 564  LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 623

Query: 1053 VIKASPHA----PDPSAFSYAPPGHPLP 1076
            +    P A    P P       PG PLP
Sbjct: 624  LAACHPAAWSRGPAPPLAFRGAPGAPLP 651



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 136/566 (24%), Positives = 188/566 (33%), Gaps = 135/566 (23%)

Query: 1737 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRD 1792
            PTPGTP+ AM R +         P+P  S        P  PT   + + +S+SE      
Sbjct: 158  PTPGTPSPAMARRSRAAGTEVGLPRPAPSAR------PRPPTEGPRKSVSSASEHSTTEP 211

Query: 1793 RERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSG--SSGGGGGSSSRPASHSHAHQ 1850
                R R      L            RP +   S S+   SS    G S+R    + AH 
Sbjct: 212  SPAARRRPSAGGGLQ-----------RPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260

Query: 1851 HSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAAT------- 1903
              P  P+   AL+  P V      K    A+ P + + L + S S+P  P+A        
Sbjct: 261  SQP-KPKGLQALRP-PQV--TPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLP 316

Query: 1904 FPPATH-----CPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLA--KPP 1955
             PPAT        LG  TL   +  L  P L P   P    P+ P A       A   PP
Sbjct: 317  SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPALALPPLQAPPSPP 373

Query: 1956 ARSGLEPASSPSKGSE--------------------PRPLVPPVSGHATIARTPAKNLAP 1995
            A   L P ++PS  +                       P  PP S   + + TP     P
Sbjct: 374  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433

Query: 1996 HHASPDPPAPPASASDPHREKTQSKPFS---------------------------IQELE 2028
              A+P    PP+  + P    + + P                             +Q L 
Sbjct: 434  SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493

Query: 2029 LRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS-----HLEGELRPKQP 2082
                 + G + +SP    P+SP+++P       L   L ++  S      L+   RP  P
Sbjct: 494  SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 553

Query: 2083 GP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLAQH----------- 2129
            GP   + G    L  L P P   PS SP    + P + GH    T               
Sbjct: 554  GPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612

Query: 2130 ---ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPGAS---CPVLDLRR 2169
                S     +    HP   S              APLP P  + PG++   C + +   
Sbjct: 613  GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672

Query: 2170 PPSDLYLPPPDHGAPARGSPHSEGGK 2195
            P S    P      P   SP + GGK
Sbjct: 673  PESATPAPGALDPGP---SPGTSGGK 695



 Score = 41.6 bits (96), Expect = 0.010
 Identities = 50/188 (26%), Positives = 62/188 (32%), Gaps = 28/188 (14%)

Query: 728 SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATG 787
           +S T   P        DT  +GP+    L A GPPP P   P   +  P     +S AT 
Sbjct: 540 ASPTLQAPRRPPTPGPDTSVSGPRLTLAL-APGPPPPPSRSPSSTLSGPDLAGHSSSATS 598

Query: 788 AP------TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841
            P         P   + ++PPP       + E AA  P        PP A   A      
Sbjct: 599 TPEELRGYDSGPEGGAAASPPP-------DAELAACHPAAWSRGPAPPLAFRGAPGAPLP 651

Query: 842 EEPVKSE------CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS-GRATTAKSSGA 894
             P          CT    EGP        +   A GAL      G S G+A     +GA
Sbjct: 652 WPPATGPGSADGLCTIYETEGP-------ESATPAPGALDPGPSPGTSGGKAAAGAGAGA 704

Query: 895 PQDSDSSA 902
              S   A
Sbjct: 705 SSRSPKQA 712



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 79/310 (25%), Positives = 110/310 (35%), Gaps = 56/310 (18%)

Query: 2158 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2217
            P A  P L   RPP     PPP   A  R    +    R P   +   +GG        +
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG-------AT 69

Query: 2218 PPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSP-------GNTSQPPAFFSK--LTE 2268
             PE     G +R++  P   R GE+  P++  S  P         T++P     K     
Sbjct: 70   IPESAPRAGPTRTSRPPASGR-GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 128

Query: 2269 SNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHAS 2328
            +   + + K  E  K+         + +   PGT     PA      M  RS+A    A 
Sbjct: 129  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTP---SPA------MARRSRA----AG 175

Query: 2329 TNMGLEAIIRKAL----MGGGGKAKVSGRPSSRKAKSPA----PGLASGDRPPSVSSVHS 2380
            T +GL      A       G  K+  S    S    SPA    P    G + P+  S+ S
Sbjct: 176  TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 235

Query: 2381 EGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPP----------PGL- 2429
                   TPL++      PS+ G+   P +P   +   G+ A  PP          P L 
Sbjct: 236  SA-----TPLSSPA-RSGPSARGTPRAPAHPSQPK-PKGLQALRPPQVTPPRKDAAPALG 288

Query: 2430 PAGSGPLAGP 2439
            P  S PLA P
Sbjct: 289  PLSSSPLATP 298


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 93/385 (24%), Positives = 134/385 (34%), Gaps = 35/385 (9%)

Query: 727  NSSDTESIPSPHTEAAKDTGQNGPK-PPATLGA-DGPPPGPPTPPPEDIPAPTEPT-PAS 783
            +  ++ S+ + + + A   G N P+ PP+  G   GPPP     P    P P +P  P  
Sbjct: 24   SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 83

Query: 784  EATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP--PVEEGEEQ----KPPAAEELAVD 837
            +    P  PP P  P  PPP   K          P  P  +G  Q     PP  +     
Sbjct: 84   QGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 143

Query: 838  TGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQD 897
                 +P       + +  P +G +   +  +  G  +    +GG+         G PQ 
Sbjct: 144  PQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 203

Query: 898  SDSSATCSADEVDEAEGGDKNRLLSP--RPSLLTPTGDPR---ANASPQKPLDLKQLKQR 952
                           +GG+K +   P  +P    P GD +   A + P KP         
Sbjct: 204  ------------PPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGN 251

Query: 953  AAAIPPIQVTKVHEPPREDAAPTKP-APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAP 1011
                PP    K   PP +     KP  PP P  PQ   P+  +  +   SP GK + P P
Sbjct: 252  QPQGPPPPPGKPQGPPPQGG--NKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPP 309

Query: 1012 PADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP 1071
                + + P   P       K  G PP   +    P PP +     P     S  + +PP
Sbjct: 310  QGGNQPQGPPPPPG------KPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPP 363

Query: 1072 GHPLPLGLHDTARPVLPRPPTISNP 1096
            G P      +   P  P PP   NP
Sbjct: 364  GKPQGPPQQEGNNPQGPPPPAGGNP 388



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 78/298 (26%), Positives = 105/298 (35%), Gaps = 57/298 (19%)

Query: 749  GPKPPATLGADGPPPG--PPTPPPE-DIPAPTEPTPASEATGAPT--------PPPAPPS 797
            GP P       GPPP   P  PPP+ D  + +  +P  +  G P         PPP P  
Sbjct: 141  GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 200

Query: 798  PSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA-----AEELAVDTGKAEEPVKSECTEE 852
            P  PPP     +   +    PP   G+ Q PP      ++      GK + P        
Sbjct: 201  PQGPPP-----QGGNKPQGPPP--PGKPQGPPPQGDNKSQSARSPPGKPQGP-------- 245

Query: 853  AEEGPAKGKDAEAAEATAEGALKAEKKEGGS---GRATTAKSSGAPQDSDSSATCSADEV 909
                P +G +         G  +    +GG+   G     K  G P    S +  S    
Sbjct: 246  ----PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPP 301

Query: 910  DEAEGGDK---NRLLSPRPSLLTPTGDPRANAS----------PQKPLDLKQLKQRAAAI 956
             + +G      N+   P P    P G P    +          PQ P      K R+A  
Sbjct: 302  GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARS 361

Query: 957  PPIQVTKVHEPPREDAA-PTKPAPPAPPPPQNLQ-PESDAPQQPGSSPRGKSRSPAPP 1012
            PP    K   PP+++   P  P PPA   PQ  Q P +  PQ P   P+G  R   PP
Sbjct: 362  PP---GKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQG-GRPSRPP 415



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 71/309 (22%), Positives = 105/309 (33%), Gaps = 45/309 (14%)

Query: 744  DTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT-PASEATGAPTPPPAPPSPSAPP 802
            D  ++   PP      GPPP     P    P P +P  P  +    P  PP P  P  PP
Sbjct: 106  DKSRSPRSPPGK--PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 163

Query: 803  PVVPKEEKEEETAAA----PPVEEGEEQK---PPAAEELAVDTGKAEEPVKSECTEEAEE 855
            P    + +   +       PP + G + +   PP  +          +P       + + 
Sbjct: 164  PQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 223

Query: 856  GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGG 915
             P +G +   +  +  G  +    +GG+         G PQ                +GG
Sbjct: 224  PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP------------QGG 271

Query: 916  DKNRLLSP--RPSLLTPTGDPRANAS---PQKPLDLKQLKQRAAAIPPIQVTKVHEPPRE 970
            +K +   P  +P    P G  ++ +S   P KP             PP    K   PP +
Sbjct: 272  NKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 331

Query: 971  DA----APTKPAPPAPPPPQNLQPESDA----------PQQPGSSPRGKSRSPAPPADKE 1016
                   P  P  P  PPPQ       A          PQQ G++P+G    P PPA   
Sbjct: 332  GGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQG----PPPPAGGN 387

Query: 1017 AEKPVFFPA 1025
             ++P   PA
Sbjct: 388  PQQPQAPPA 396



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 67/249 (26%), Positives = 80/249 (32%), Gaps = 32/249 (12%)

Query: 957  PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKE 1016
            PP    K   PP     P  P P     PQ   P    PQ P      K + P PP   +
Sbjct: 40   PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 99

Query: 1017 AEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLP 1076
               P        +  + P  PP    G P   PP+      P  P P      PPG P  
Sbjct: 100  GPPP------QGDKSRSPRSPP----GKPQGPPPQG--GNQPQGPPP------PPGKPQG 141

Query: 1077 LGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPV 1136
                   +P  P PP     PP     K  S   R      QG       P  +    P 
Sbjct: 142  PPPQGGNKPQGPPPPGKPQGPPPQGDNKSRS--SRSPPGKPQG-------PPPQGGNQPQ 192

Query: 1137 GPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVP- 1195
            GP     P P  P+   P  G K +   P G+   P   G   +Q A    G   G  P 
Sbjct: 193  GPP----PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQ 248

Query: 1196 GGSITKGIP 1204
            GG+  +G P
Sbjct: 249  GGNQPQGPP 257



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 66/274 (24%), Positives = 98/274 (35%), Gaps = 31/274 (11%)

Query: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPT-PASEATGAPTPPP 793
           P P  +    + ++ P  P      GPPP     P    P P +P  P  +    P  PP
Sbjct: 162 PPPQGDNKSRSSRSPPGKP-----QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 216

Query: 794 APPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA-----EELAVDTGKAEEPVKSE 848
            P  P  PPP   + + + ++A +PP   G+ Q PP       +      GK + P   +
Sbjct: 217 PPGKPQGPPP---QGDNKSQSARSPP---GKPQGPPPQGGNQPQGPPPPPGKPQGP-PPQ 269

Query: 849 CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
              + +  P  GK         +G  K+       G+       G  Q           +
Sbjct: 270 GGNKPQGPPPPGKPQGPPP---QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326

Query: 909 VDEAEGGDKNRLLSP--RPSLLTPTGDPR---ANASPQKPLDLKQLKQRAAAIPPIQVTK 963
               +GG+K +   P  +P    P G  +   A + P KP    Q +      PP     
Sbjct: 327 GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP---PP 383

Query: 964 VHEPPREDAAPTKPAPPAPP-PPQNLQPESDAPQ 996
               P++  AP    P  PP PPQ  +P S  PQ
Sbjct: 384 AGGNPQQPQAPPAGQPQGPPRPPQGGRP-SRPPQ 416



 Score = 36.6 bits (83), Expect = 0.31
 Identities = 69/316 (21%), Positives = 82/316 (25%), Gaps = 83/316 (26%)

Query: 1954 PPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLA--PHHASPDPPAPPASASD 2011
            PP + G +P   P  G    P  PP    +   R+P       P      P  PP     
Sbjct: 81   PPPQGGNKPQGPPPPGKPQGP--PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGK 138

Query: 2012 PHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS 2071
            P     Q                      P+G  P      P    D          +KS
Sbjct: 139  PQGPPPQG------------------GNKPQGPPPPGKPQGPPPQGD----------NKS 170

Query: 2072 HLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHIS 2131
                    K  GP   GG     P   P P  +P   P                      
Sbjct: 171  RSSRSPPGKPQGPPPQGGNQPQGP---PPPPGKPQGPP---------------------- 205

Query: 2132 EVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD-----LRRPPSDLYLPPPDHGAPAR 2186
                       PQ  + P   P    P    P  D      R PP     PPP  G   +
Sbjct: 206  -----------PQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQ 254

Query: 2187 GSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG--HSRSAVYPLLYRDGEQTE 2244
            G P   G  + P P      G    G  P   P+G    G   SRS+  P     G+   
Sbjct: 255  GPPPPPGKPQGPPPQG----GNKPQGPPPPGKPQGPPPQGGSKSRSSRSP----PGKPQG 306

Query: 2245 PSRMGSKSPGNTSQPP 2260
            P   G   P     PP
Sbjct: 307  PPPQGGNQPQGPPPPP 322



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 27/92 (29%), Positives = 31/92 (33%), Gaps = 9/92 (9%)

Query: 2170 PPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPG-HS 2228
            PP     PPP  G   +G P   G  + P P      G    G  P   P+G    G  S
Sbjct: 53   PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG----GNKPQGPPPPGKPQGPPPQGDKS 108

Query: 2229 RSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPP 2260
            RS   P     G+   P   G   P     PP
Sbjct: 109  RSPRSP----PGKPQGPPPQGGNQPQGPPPPP 136


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 85.1 bits (209), Expect = 8e-16
 Identities = 101/375 (26%), Positives = 136/375 (36%), Gaps = 40/375 (10%)

Query: 728  SSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATG 787
            +S   ++P+P    +       P+ P +  A  PPP  PT P   +P P EPT  + A  
Sbjct: 1001 ASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVP 1060

Query: 788  APTPP-------PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGK 840
             P  P       P P  P++P   VP  E+    AAA P    EE   PAA   AV T  
Sbjct: 1061 TPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP--EEPTSPAA---AVPT-- 1113

Query: 841  AEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDS 900
             EEP          E PA    A A     E A  A         A+ A +   P++S S
Sbjct: 1114 PEEPASPAAAVPTPEEPA--SPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESAS 1171

Query: 901  SATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQ 960
             A       + A        L    S       P A  +      L++    AA++P  +
Sbjct: 1172 PAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVA-----TLEEFTSPAASVPTSE 1226

Query: 961  VTKVHEPPREDAA---PTKPAPPAPPPPQNLQPESDA----PQQPGSSPRGKSRSPAPPA 1013
                 EP    AA   P +P  PA   P   +P S A      +  SSP     +P  PA
Sbjct: 1227 -----EPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPA 1281

Query: 1014 DKEAE-KPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPG 1072
               A    +  PA  A A   P       + +P    P   + A P A  P     +P G
Sbjct: 1282 SPAAAVSNLEEPASPAAAVPTPE-----VAAIPAASVPTPEVPAIPAAAVPPMEEVSPIG 1336

Query: 1073 HP-LPLGLHDTARPV 1086
             P L +  H  + P+
Sbjct: 1337 VPFLGVSAHTDSVPI 1351



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 90/356 (25%), Positives = 129/356 (36%), Gaps = 46/356 (12%)

Query: 675  KERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNN--SSDTE 732
            +E +    +   P   +  AA  P  E+    A+ V   EE     A        +S   
Sbjct: 985  EEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAA 1044

Query: 733  SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPP 792
            ++P+P    +       P+ P +  A  P P  PT P   +P P EPT  S A   PTP 
Sbjct: 1045 AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPT--SPAAAVPTPE 1102

Query: 793  ---------PAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAA---EELAVDTGK 840
                     P P  P++P   VP  E+    AAA P  E      PA    EE A     
Sbjct: 1103 EPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVA 1162

Query: 841  AEEPVKSECTEEAEEGPAKGKDAEAAEATAE------------GALKAEKKEGGSGRATT 888
               P +S     A   PA+     A  AT E             A+ A  +E  S  A+ 
Sbjct: 1163 VPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASV 1222

Query: 889  AKS-------SGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR----PSLLTPTGDPRAN 937
              S       +      + ++  +A    E        +L+P     P+   PT  P   
Sbjct: 1223 PTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPT--PEEP 1280

Query: 938  ASPQKPL-DLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAP--PPPQNLQP 990
            ASP   + +L++    AAA+P  +V  +  P      P  PA PA   PP + + P
Sbjct: 1281 ASPAAAVSNLEEPASPAAAVPTPEVAAI--PAASVPTPEVPAIPAAAVPPMEEVSP 1334



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 91/384 (23%), Positives = 133/384 (34%), Gaps = 37/384 (9%)

Query: 731  TESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 790
            TE   +P       T  + P+ P T       P  P  P   +P P EPT  S A   PT
Sbjct: 965  TEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPT--SPAAAVPT 1022

Query: 791  P-PPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSEC 849
            P  P  P+ + PPP       EE T+ A  V   EE   PAA   AV T   EEP     
Sbjct: 1023 PEEPTSPAAAVPPP-------EEPTSPAAAVPTPEEPTSPAA---AVPT--PEEPTSPAA 1070

Query: 850  TEEAEEGPAKGKDA--EAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSAD 907
                 E P     A     E T+  A     +E       T+ ++  P   + ++  +A 
Sbjct: 1071 AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEE------PTSPAAAVPTPEEPASPAAAV 1124

Query: 908  EVDEAEGGDKNRLLSPR----PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTK 963
               E        + +P     P+   PT +  A+A+   P   +     AA   P +   
Sbjct: 1125 PTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESAS 1184

Query: 964  VHEPPREDAAPTKPAPPAPPP-------PQNLQPESDAP--QQPGSSPRGKSRSPAPPAD 1014
                      PT PA   P P        +   P +  P  ++P S     S    P + 
Sbjct: 1185 FAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSP 1244

Query: 1015 KEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYA-PPGH 1073
              A   +  P  +A A   P +     + +P P  P     A  +  +P++ + A P   
Sbjct: 1245 AAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPE 1304

Query: 1074 PLPLGLHDTARPVLPRPPTISNPP 1097
               +       P +P  P  + PP
Sbjct: 1305 VAAIPAASVPTPEVPAIPAAAVPP 1328



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 134/590 (22%), Positives = 192/590 (32%), Gaps = 117/590 (19%)

Query: 711  SGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGP----- 765
            +GN E ++EE    +   S T ++P+   + A D     P+   ++ A   P G      
Sbjct: 817  AGNTEPVLEEWIPVLQRPSRTAAVPT--VKDALDAALPSPEEGTSIAAVPAPEGTAVVAA 874

Query: 766  --PTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG 823
              P P  + + A        + T A    P   +  A    VP     E TAA   V   
Sbjct: 875  LVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVP-----EGTAAVAAVSSP 929

Query: 824  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS 883
            EE  P  A  +  +   A      E    A   P   +D      T EG +         
Sbjct: 930  EETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEEDG-----TPEGPV--------- 975

Query: 884  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP 943
               T A +  AP++ D++A      V   E         P P    PT    A  +P++P
Sbjct: 976  ---TPATTVHAPEEPDTAAV----RVSTPEEPASPAAAVPTPE--EPTSPAAAVPTPEEP 1026

Query: 944  LDLKQLKQRAAAIPPIQ--------VTKVHEPPREDAA------PTKPAPPAPPPPQNLQ 989
                     AAA+PP +        V    EP    AA      PT PA   P P +   
Sbjct: 1027 TS------PAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTS 1080

Query: 990  PES--DAPQQPGSSPRGKSRSPAPPADKEAEKPV-FFPAFAAEAQKLPGDPPCWTSGLP- 1045
            P +    P++P +SP     +P  P    A  P    PA  A A   P +P    + +P 
Sbjct: 1081 PAAAVPTPEEP-TSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPT 1139

Query: 1046 -----FPVP----PREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVL----PRPPT 1092
                 FP P    P E   A+   P P   +      P P      A  V     P  P 
Sbjct: 1140 PEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPA 1199

Query: 1093 ISNPPPL---------------ISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVG 1137
             S P P                + +++ P+ L   +    +  S    VP  E   +   
Sbjct: 1200 ASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAA 1259

Query: 1138 PV---------TMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRG 1188
             V            +P P +P   A      +E  SP      PE   +P A        
Sbjct: 1260 AVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAA-------- 1311

Query: 1189 TALGSVPGGSITKGIPSTRVP-----SDSAITYRGSITHGTPADVLYKGT 1233
                SVP   +   IP+  VP     S   + + G   H     +  +GT
Sbjct: 1312 ----SVPTPEV-PAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGT 1356



 Score = 36.6 bits (83), Expect = 0.31
 Identities = 77/366 (21%), Positives = 113/366 (30%), Gaps = 70/366 (19%)

Query: 1882 EPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPER 1941
            EP T  V R ++   P  PAA  P                T  EP       P    P  
Sbjct: 986  EPDTAAV-RVSTPEEPASPAAAVP----------------TPEEPTSPAAAVPTPEEPTS 1028

Query: 1942 PRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPD 2001
            P A       A PP      PA++     EP       +  A    TP +  +P  A P 
Sbjct: 1029 PAA-------AVPPPEEPTSPAAAVPTPEEP-------TSPAAAVPTPEEPTSPAAAVPT 1074

Query: 2002 PPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL 2061
            P  P + A+     +  + P +             +  +PE  EP SP ++     +   
Sbjct: 1075 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE--EPASPAAAVPTPEEPAS 1132

Query: 2062 PKHLEELDKSHLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSPLLQT------- 2113
            P        + +     P  P P V    E+A      P PE   S +  + T       
Sbjct: 1133 P-------AAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASF 1185

Query: 2114 -------------APGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLY-SFPG 2159
                         A  V     +V   +  +       T   P  L+A +  P   + P 
Sbjct: 1186 AAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPA 1245

Query: 2160 ASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPP 2219
            A+ P L+     +   L P +  +PA   P  E      EP   +      +  EP SP 
Sbjct: 1246 AAVPTLEEPTSSAAAVLTPEELSSPAASVPTPE------EPASPAAAVSNLE--EPASPA 1297

Query: 2220 EGMTEP 2225
              +  P
Sbjct: 1298 AAVPTP 1303


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 133/559 (23%), Positives = 193/559 (34%), Gaps = 113/559 (20%)

Query: 692  EEAAFPPVVEDEEM----EASGVSGNEEEMVEEAEATVNNSS-DTESIPSPHTEAAKDTG 746
            EE+   P  E+  +    E+S  S  EE  +   E +  + + +T   P P         
Sbjct: 490  EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF 549

Query: 747  QNGP----------KPPATLGADGPPP--GPPTPPPEDIPAPTEPTPASEAT-----GAP 789
            +  P           PP       PPP   P +PPPE+  +P  P P +         +P
Sbjct: 550  EESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEE--SPMSPPPEASRLFPPFEESP 607

Query: 790  TPPPAPPSPSAPPPVVPK-EEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSE 848
              PP   SP +PPP   +     E++  +PP EE     PP    L+        PV S 
Sbjct: 608  LSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS------PLPVVSR 661

Query: 849  CTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA---PQDS------- 898
             +   EE P      E+  +    A +       S  +   + S A   P+DS       
Sbjct: 662  LSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLE 721

Query: 899  --------DSSATCSADEVDEAEGGDKNRLLSPRPS---LLTPTGDPRANASPQKPL--- 944
                    +    C   E        +   LSPRP    L     +P  +  P++P    
Sbjct: 722  ESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCA 781

Query: 945  --DLKQLKQRAAA--IPPIQVTKVHEPPREDAAPTKPAPPAP-----PPPQNLQPESDAP 995
              +   L  +A    + P Q  ++H  P+ +     P P  P     P   +L P+S+ P
Sbjct: 782  VPEEPHLSPQAEGPHLSP-QPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP 840

Query: 996  ---------------QQPGSSPRGKSRSPAPPADKEA--EKPVFFPAFAAEAQKLPGDPP 1038
                           ++P  SPR + + P  P    A  E P+F P        L G+P 
Sbjct: 841  CLSPRPEESHLSPELEKPPLSPRPE-KPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPA 899

Query: 1039 CWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPP 1098
                G P            P +P P     +P G P    L     P  P PP +S   P
Sbjct: 900  LSEPGEP------------PLSPLPEELPLSPSGEP---SLSPQLMPPDPLPPPLS---P 941

Query: 1099 LISSAKHPSV-----LERQIGAISQG-MSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKL 1152
            +I++A  P++     LE   GA         L  P  E   +P        P P+ P  L
Sbjct: 942  IITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMIL 1001

Query: 1153 APFSGVKQEQLSPRGQAGP 1171
             P  G      SP G A P
Sbjct: 1002 PPSPG------SPVGPASP 1014



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 131/543 (24%), Positives = 195/543 (35%), Gaps = 91/543 (16%)

Query: 704  EMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGP-KPPATLGADGPP 762
            + EA  +     ++  + EA +N   +   +P P         +  P  PP       PP
Sbjct: 413  QCEAKPLGKAGVQLEPQLEAPLNE--EMPLLPPPEESPLSPPPEESPTSPPPEASRLSPP 470

Query: 763  P--------------------GPPTPPPEDIPA--PTEPTPASEATGAPTPPP--APPSP 798
            P                     P +PPPE+ P   P E +P S    +P  PP  +PPSP
Sbjct: 471  PEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSP 530

Query: 799  ------SAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE 852
                  S PP   P     EE+  +PP EE     PP A  L      +  P +S  +  
Sbjct: 531  ALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL------SPPPEESPMSPP 584

Query: 853  AEEGP-AKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDE 911
             EE P +   +A       E +  +   E          S  +P   DS  +   +E   
Sbjct: 585  PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPM 644

Query: 912  AEGGDKNRLLSPRP--SLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPR 969
            +   + +R LSP P  S L+P         P +   L    + +   PP + +++  PP 
Sbjct: 645  SPPPEVSR-LSPLPVVSRLSP---------PPEESPLSPPPEESPTSPPPEASRLSPPPE 694

Query: 970  EDAAPTKPAP---PAPPPPQN---LQPESDAPQQP-GSSPRGKSRSPAPPADKEAEKPVF 1022
            +  +PT P P   PA PPP++     P  ++P  P    P+   RS  P      E+P  
Sbjct: 695  D--SPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHL 752

Query: 1023 FPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH-- 1080
             P           + P  +     P P    + A P  P  S  +  P   P P  LH  
Sbjct: 753  SPRPEEPHLSPQAEEPHLS-----PQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLS 807

Query: 1081 -DTARPVL---PRPPTISNPP-----------PLISSAKHPSVLERQIGAISQGMSVQLH 1125
              T  P L   P  P +S  P           P +S     S L  ++      +S +  
Sbjct: 808  PQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELE--KPPLSPRPE 865

Query: 1126 VPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQ---AGPPESLGVPTAQE 1182
             P  E  + P        P P +P  L+P  G  +  LS  G+   +  PE L +  + E
Sbjct: 866  KPPEEPGQCPAPEELPLFPPPGEP-SLSPLLG--EPALSEPGEPPLSPLPEELPLSPSGE 922

Query: 1183 ASV 1185
             S+
Sbjct: 923  PSL 925



 Score = 75.5 bits (184), Expect = 6e-13
 Identities = 95/361 (26%), Positives = 136/361 (37%), Gaps = 45/361 (12%)

Query: 735  PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPA 794
            P P    AK  G+ G +    L A      P  PPPE+  +P  P P    T   +PPP 
Sbjct: 409  PGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEE--SPLSPPPEESPT---SPPPE 463

Query: 795  PPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAE 854
                S PP  +P     E    + P+EE     PP    L+        P +S      E
Sbjct: 464  ASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS-------PPPESSPFSPLE 516

Query: 855  EGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEG 914
            E P    +        E  L    +           S  +P   +S  +   +E+  +  
Sbjct: 517  ESPLSPPEESPPSPALETPLSPPPE----------ASPLSPPFEESPLSPPPEELPTSPP 566

Query: 915  GDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP 974
             + +R LSP P   +P   P   +    P +  +L       PP + + +  PP E  +P
Sbjct: 567  PEASR-LSPPPE-ESPMSPPPEESPMSPPPEASRL------FPPFEESPLSPPPEE--SP 616

Query: 975  TKPAPPA---PPPPQNLQPESDAPQQ-PGSSPRGKSR-SPAPPADKEAEKPVFFPAFAAE 1029
              P P A    PPP++  P S  P++ P S P   SR SP P   + +  P   P  +  
Sbjct: 617  LSPPPEASRLSPPPED-SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP-LSPP 674

Query: 1030 AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR 1089
             ++ P  PP   S L    PP E    SP +P P     +PP     + L     P+LP 
Sbjct: 675  PEESPTSPPPEASRLS---PPPE---DSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPL 728

Query: 1090 P 1090
            P
Sbjct: 729  P 729



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 121/468 (25%), Positives = 161/468 (34%), Gaps = 115/468 (24%)

Query: 761  PPPGPPTPPPEDIPAPTEPTPASEATGAPTP------PPAPP--SPSAPPPVVPKEEKEE 812
            PP  PP P P   PA      AS   GA  P      PP  P   PS P P +       
Sbjct: 2193 PPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSL 2252

Query: 813  ETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG 872
            +  A P             E   V  GKA EP+ S         P  G+  +        
Sbjct: 2253 DNLAVP-------------ESPGVGGGKASEPLLSP--------PPFGESRK-------- 2283

Query: 873  ALKAEKKEGGSGRATTAKSSGAPQDSDSSAT------CSADEVDEAEGGDKNRLLSPRPS 926
            AL+ +K+E G+   +    +    DS SS T          +V +A        L+PR S
Sbjct: 2284 ALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAP-------LTPRAS 2336

Query: 927  LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED----AAPTKP--APP 980
             + P   P     PQ+P             PP Q      P   D     + T P   PP
Sbjct: 2337 QVEPQ-SPGLGLRPQEP-------------PPAQALAPSPPSHPDIFRPGSYTDPYAQPP 2382

Query: 981  APPPPQNLQPESDAPQQPGSSPRGK-SRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1039
              P PQ   PES     P S P    SR PA P  + + +    P      + L  +  C
Sbjct: 2383 LTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTP------RPLSAEAFC 2436

Query: 1040 WTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPL 1099
                 P PV PR      P++  PS      P  PL        +P  P+PP ++     
Sbjct: 2437 -----PSPVTPR-FQSPDPYSRPPSRPQSRDPFAPL-------HKPPRPQPPEVAFK--- 2480

Query: 1100 ISSAKHPSVLERQI-GAISQGMSVQLH--VPYSE---HAKAPVGPVTMGLPLPM------ 1147
              S  H S+       A+  G + +LH  VP  +     ++P     +G P PM      
Sbjct: 2481 AGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQ 2540

Query: 1148 ---DPKKLAPFSGVKQEQLSP----RGQAGPPESLGVPTAQEASVLRG 1188
               +P    P   V Q  L P        GP  +LG P +   +V  G
Sbjct: 2541 AVGEPSLKPP---VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATG 2585



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 92/375 (24%), Positives = 126/375 (33%), Gaps = 37/375 (9%)

Query: 775  APTEP--TPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAE 832
            +P EP  TP  E           P       + PKE    +  A P  + G + +P    
Sbjct: 373  SPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEA 432

Query: 833  ELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGG---SGRATTA 889
             L  +      P +S  +   EE P       +  +     L A         S     +
Sbjct: 433  PLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEES 492

Query: 890  KSSGAPQDSDSSATCSADEVDEAEGGDKN--RLLSPRPSLLTPTGDPRANASPQKP---- 943
              S  P++S  S    +      E    +      P P+L TP   P   ASP  P    
Sbjct: 493  PLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPP-PEASPLSPPFEE 551

Query: 944  LDLKQLKQRAAAIPPIQVTKVHEPPRED--AAPTKPAPPAPP-------PPQNLQPESDA 994
              L    +     PP + +++  PP E   + P + +P +PP       PP    P S  
Sbjct: 552  SPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPP 611

Query: 995  PQQ-PGSSPRGKSRSPAPPADK-----EAEKPVFFPAFAAEAQKLPG----DPPCWTSGL 1044
            P++ P S P   SR   PP D        E P+  P   +    LP      PP   S  
Sbjct: 612  PEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEES-- 669

Query: 1045 PFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAK 1104
            P   PP E    SP +P P A   +PP    P        P  P P       PL  S  
Sbjct: 670  PLSPPPEE----SPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPL 725

Query: 1105 HPSVLERQIGAISQG 1119
             P   E Q+   S+G
Sbjct: 726  LPLPEEPQLCPRSEG 740



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 160/680 (23%), Positives = 219/680 (32%), Gaps = 105/680 (15%)

Query: 732  ESIPSPHTEAAKDTGQNGPKPPATLGADGPPP--GPPTPPPED------------IPAPT 777
            ES  SP  EA++ +      PP       PPP   P +PPPED            +P P 
Sbjct: 677  ESPTSPPPEASRLS------PPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPE 730

Query: 778  EPTPASEATG------------APTPPPAPPSPSAPPPVVPKEEKEEETAAAP------P 819
            EP     + G            +P P     SP A  P +  + +E    A P      P
Sbjct: 731  EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSP 790

Query: 820  VEEGEEQKPPAAE-ELAVDTGKA------EEPVKSECTEEAE-----EGPAKGKDAEAAE 867
              EG    P   E  L+  T +       EEP  S   EE+      E P      E + 
Sbjct: 791  QAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESH 850

Query: 868  ATAEG-----ALKAEKKEGGSGRATTAKSSGA-PQDSDSSATCSADEVDEAEGGDKNRLL 921
             + E      + + EK     G+    +     P   + S +    E   +E G+     
Sbjct: 851  LSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSP 910

Query: 922  SPRPSLLTPTGDPRANAS--PQKPLDLKQLKQRAAAIPP-----------IQVTKVHEPP 968
             P    L+P+G+P  +    P  PL         AA PP                  +P 
Sbjct: 911  LPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPE 970

Query: 969  REDAAPTKPAPPAPPPPQN-LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF- 1026
               AAP    P +PPP  N   PE   P     SP G    PA P   E   P   P   
Sbjct: 971  SPLAAPILETPISPPPEANCTDPEPVPPMILPPSP-GSPVGPASPILMEPLPPQCSPLLQ 1029

Query: 1027 -AAEAQKLPG---DPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT 1082
             +   Q  P     PP     +P P+ P   +       +           P    L  +
Sbjct: 1030 HSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPS 1089

Query: 1083 ARPVLPRP-PTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTM 1141
            A   LP P   +S P P  + A        +  A   G+      P        +     
Sbjct: 1090 ATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELK 1149

Query: 1142 GLPLPMDPKKLAPFSGVK---------------QEQLSPRGQAG--PPESLGVPTAQEAS 1184
            G P+ +DP++LAP + ++               +EQ  PR      PP  +      E S
Sbjct: 1150 GSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEIS 1209

Query: 1185 VL-RGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSP 1243
             L +G A  S PG     G P        ++    S       D       T  + E   
Sbjct: 1210 NLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDD 1269

Query: 1244 SRL-DRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTY 1302
            S L D G   S  K     EG+KG   S      + Q     GRSSS P           
Sbjct: 1270 SLLCDAGTAISGGKA----EGEKGRRRSSPARSRIKQ-----GRSSSFPGRRRPRGGAHG 1320

Query: 1303 DMMEGRVGRAISSASIEGLM 1322
                GR     +++SIE L+
Sbjct: 1321 GRGRGRARLKSTASSIETLV 1340



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 108/426 (25%), Positives = 138/426 (32%), Gaps = 111/426 (26%)

Query: 1836 GGSSSRPASHSHAHQHSPIS-----PRTQDALQQRPSVLH----NTGMKGIITAVEPSTP 1886
            GG + R    S A QH+P+      P   D     P  L+         G +T+++P  P
Sbjct: 354  GGQTIR----SVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEP 409

Query: 1887 TVLRSTSTSSPVRPAAT----------------FPPATHCPLGGTLDGVYPTLMEPVLLP 1930
              L+  +   P+  A                   PP    PL        P    P   P
Sbjct: 410  GPLQCEA--KPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSP------PPEESPTSPP 461

Query: 1931 KEAPRVARP--ERPRADTGHAF----------LAKPPARSGLEPA--SSPSKGSEPRPLV 1976
             EA R++ P  E P +    A           L+ PP  S L P   SSP    E  PL 
Sbjct: 462  PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLS 521

Query: 1977 PPVSGHATIA-RTPAKNLAPHHASP-DPPAPPASASDPHREKTQSKPFSIQELELRSLGY 2034
            PP     + A  TP     P  ASP  PP   +  S P  E   S P             
Sbjct: 522  PPEESPPSPALETPLS--PPPEASPLSPPFEESPLSPPPEELPTSPP------------P 567

Query: 2035 HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR-PKQPGPVKLGGEAAH 2093
              S  SP   E  SP+S P        P     L     E  L  P +  P+    EA+ 
Sbjct: 568  EASRLSPPPEE--SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEAS- 624

Query: 2094 LPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAP 2153
               L P PE  P S P                          ++     P ++S   P P
Sbjct: 625  --RLSPPPEDSPMSPP-------------------------PEESPMSPPPEVSRLSPLP 657

Query: 2154 LYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGI 2213
            + S          L  PP +  L PP   +P   SP  E  + SP P  +      ED  
Sbjct: 658  VVS---------RLSPPPEESPLSPPPEESPT--SPPPEASRLSPPPEDSPTSPPPED-- 704

Query: 2214 EPVSPP 2219
             P SPP
Sbjct: 705  SPASPP 710



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 142/619 (22%), Positives = 209/619 (33%), Gaps = 102/619 (16%)

Query: 1734 LVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDR 1793
            L PP    P+ A++     P    P S     SPLSP      T P   +S  R      
Sbjct: 520  LSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEAS--RLSPPPE 577

Query: 1794 ERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPASHSHAHQHSP 1853
            E       E+S ++       A    P  E+S  S              +  S   + SP
Sbjct: 578  ESPMSPPPEESPMSPP---PEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSP 634

Query: 1854 ISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLG 1913
            +SP  +++    P  +       +++ + P            SP+ P             
Sbjct: 635  MSPPPEESPMSPPPEVSRLSPLPVVSRLSP--------PPEESPLSP------------- 673

Query: 1914 GTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGS--- 1970
                   P    P   P EA R++ P            + PP  S   PAS P + S   
Sbjct: 674  -------PPEESPTSPPPEASRLSPPPEDSP------TSPPPEDS---PASPPPEDSLMS 717

Query: 1971 ---EPRPLVPPVSGHATIARTPAKNLAPH----HASPDPPAPPAS--ASDPHREKTQSKP 2021
               E  PL+P         R+   +L+P     H SP P  P  S  A +PH      +P
Sbjct: 718  LPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEP 777

Query: 2022 --FSIQE---LELRSLGYHGS------SYSPEGVEP-VSPVSSPSLTHDKGLPKHLE--- 2066
               ++ E   L  ++ G H S        SP+  EP +SPV        +    HL    
Sbjct: 778  CLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQS 837

Query: 2067 -------ELDKSHLEGELR--PKQPGPVKLGGEAAHLPHLRPL----PESQPSSSPLL-Q 2112
                     ++SHL  EL   P  P P K   E    P    L    P  +PS SPLL +
Sbjct: 838  EEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGE 897

Query: 2113 TAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPS 2172
             A    G   +  L + +    + + +         PLP PL        P++    PP+
Sbjct: 898  PALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPL-------SPIITAAAPPA 950

Query: 2173 DLYLPPPDHGAPARGSPHSEGGKRSP--EPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRS 2230
               L   ++   A+G    E    +P  E   +          EPV P      PG    
Sbjct: 951  LSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVG 1010

Query: 2231 AVYPLLYRD-GEQTEP----SRMGSKSPGNTSQPPAF----FSKLTESNSAMVKSKKQEI 2281
               P+L      Q  P    S +   SP +   PPA      S L+     +  S + E+
Sbjct: 1011 PASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAEL 1070

Query: 2282 NKKLNTHNRNEPEYNISQP 2300
            + ++ T   +EPE    +P
Sbjct: 1071 H-EMETEKVSEPECPALEP 1088



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 27/70 (38%), Positives = 34/70 (48%), Gaps = 2/70 (2%)

Query: 761  PPPGPPTPPPEDI-PAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819
            PPP  P+PPP  + P+P  P P       PT P A P   +P P+    E       A P
Sbjct: 4909 PPPEEPSPPPSPLAPSPASP-PTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARP 4967

Query: 820  VEEGEEQKPP 829
             EEGE+ +PP
Sbjct: 4968 PEEGEDSRPP 4977



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 126/637 (19%), Positives = 221/637 (34%), Gaps = 137/637 (21%)

Query: 475  KNENYKSLVRRSYRRRGKSQQQQQQQQ-QQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEE 533
            + +  + L ++   ++ + QQQQQQQQ QQQQQQQ Q   +  Q+++ +++++ + ++++
Sbjct: 3913 QQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQ 3972

Query: 534  EKPEVENDKEDLLKEKTDD------------------------------TSGEDNDEKEA 563
            ++  + N    LL  +                                 T  E N    A
Sbjct: 3973 QQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPA 4032

Query: 564  V---ASKGRKTANSQGRRKGRITRSMANEANSEE----------AITPQQSAELASMELN 610
            V   A++G  T        G    SMA E    +           + PQ   + +S++L 
Sbjct: 4033 VSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQ 4092

Query: 611  ESSRWTEEEMETAK----KGLLEHGR-------NWSAIARMVGSKTVSQCKNFYFNYKKR 659
               R   ++ +        G   HG+         S++  ++   +VS         +  
Sbjct: 4093 PPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS------LGDQPG 4146

Query: 660  QNLDEIL--QQHKLKMEKERNARRKKKKAPAAASEEAAFP-----PVVEDEEMEASGVSG 712
                 +L  QQ  L+   + N   +  K           P     P V     +  GV  
Sbjct: 4147 SMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLA 4206

Query: 713  NEEEM-------VEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGAD---GPP 762
               ++        ++ +A +      +S     T   ++ G         LG     G  
Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266

Query: 763  PGPPTPPPEDIPAPTEP--------TPASEATGA------PTPPPAPPSPSAPPPVVPKE 808
            PGP T P +++ A   P         P + +TG       PTPPP+ P     P  +P  
Sbjct: 4267 PGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSP 4326

Query: 809  EKEEETAAAPPVEEGEEQKP-------------PAAEELAVDT------GKAEEPVKSEC 849
              +  T A  P       KP             PAA +LA DT      G  + P     
Sbjct: 4327 SSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLA-DTLFSKGLGPWDPPDNLAE 4385

Query: 850  TEEAEE-----GPAKGKDAEAAEATAEGALKAEKKE---GGSGRATTAKSSGAPQDSDSS 901
            T++ E+     G     + +     ++ ++K E +E       ++   +++G P  +  +
Sbjct: 4386 TQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGT 4445

Query: 902  ATCSADEVDEAEGGD---KNRLLSPRPSLLTPTGDPRANASPQKPLD--LKQLKQRAAAI 956
            +         +E G    +  L +    L T  G     A     +D  L  L+Q+    
Sbjct: 4446 SNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGT 4505

Query: 957  PPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993
            P           +EDAA  K   P  P P+ +Q  SD
Sbjct: 4506 P---------SNKEDAAARK---PLTPKPKRVQKASD 4530



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 79/321 (24%), Positives = 103/321 (32%), Gaps = 69/321 (21%)

Query: 1886 PTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRAD 1945
            P V     +  P   A  +P     P   T    YP    P   P + P +    RP A 
Sbjct: 2165 PQVPAQVPSQDPFGLAPAYPLEPRFP---TAPPTYPPYPSPTGAPAQPPMLGASSRPGAG 2221

Query: 1946 TGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPA-KNLAPHHASPDPPA 2004
                F   PP     +P       S P P + P        R P+  NLA       P +
Sbjct: 2222 QPGEFHTTPPGTPRHQP-------STPDPFLKP--------RCPSLDNLAV------PES 2260

Query: 2005 PPASASDPHREKTQSKPF----SIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKG 2060
            P               PF       E++   LG    SY P  +  V   SS   TH  G
Sbjct: 2261 PGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSG--THLGG 2318

Query: 2061 LPKHLEELDKSHL---EGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGV 2117
            L     ++ K+ L     ++ P+ PG   LG      P  + L  S PS   + +  PG 
Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPG---LGLRPQEPPPAQALAPSPPSHPDIFR--PG- 2372

Query: 2118 KGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLP 2177
                                YT  + Q    P P P    P  SC  L  R  PSD +  
Sbjct: 2373 -------------------SYTDPYAQPPLTPRPQPP---PPESCCALPPRSLPSDPFSR 2410

Query: 2178 PPDHGAPARGSPHSEGGKRSP 2198
             P        SP S+   +SP
Sbjct: 2411 VP-------ASPQSQSSSQSP 2424



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 16/60 (26%), Positives = 44/60 (73%)

Query: 484  RRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE 543
            ++  +++ + QQQQQQQ QQQQQ QQQ + +  Q+++ +++++++ ++++++ + +  ++
Sbjct: 3903 QQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQ 3962



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 18/89 (20%), Positives = 50/89 (56%)

Query: 494  QQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDT 553
            QQQQQ QQQQQQQ QQQ   +  Q ++ +++++ + +++++  + +   +   +++    
Sbjct: 3907 QQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQF 3966

Query: 554  SGEDNDEKEAVASKGRKTANSQGRRKGRI 582
              +   ++  + ++ R   + Q +++ ++
Sbjct: 3967 QQQQQQQQMGLLNQSRTLLSPQQQQQQQV 3995



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 17/64 (26%), Positives = 44/64 (68%)

Query: 486  SYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDL 545
            S ++  + QQ QQQQQ QQQQQQQ    +  Q+++ +++++++  +++++ +++  ++ L
Sbjct: 3896 SLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQL 3955

Query: 546  LKEK 549
             +++
Sbjct: 3956 QQQQ 3959



 Score = 40.0 bits (92), Expect = 0.028
 Identities = 17/72 (23%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKT 550
            G  QQ QQQQQ QQQQQ QQ   +  Q++  ++ ++++ ++++++ +++  ++  L+++ 
Sbjct: 3895 GSLQQLQQQQQLQQQQQLQQQQQQQLQQQ--QQLQQQQLQQQQQQQQLQQQQQQQLQQQQ 3952

Query: 551  DDTSGEDNDEKE 562
                 +   +++
Sbjct: 3953 QQLQQQQQQQQQ 3964



 Score = 39.3 bits (90), Expect = 0.048
 Identities = 72/341 (21%), Positives = 119/341 (34%), Gaps = 53/341 (15%)

Query: 710  VSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPP 769
            ++G+E +++   +  ++ + D + I + H    +   +   +     G +  P GP   P
Sbjct: 3042 LNGDEFDLLAYTDPELD-TGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERP 3100

Query: 770  PEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKE-------EETAAAPPVEE 822
            P          PA++A+        P   S  P V PK E+        + T A P VE 
Sbjct: 3101 P----------PAADAS-------EPRLASVLPEVKPKVEEGGRHPSPCQFTIATPKVEP 3143

Query: 823  GEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP--AKGKDAEAAEATAEGALKAE--- 877
                  PAA  L +     +  + S  T     GP  + G  AE A   A G   A    
Sbjct: 3144 A-----PAANSLGLGLKPGQSMMGSRDTRMG-TGPFSSSGHTAEKASFGATGGPPAHLLT 3197

Query: 878  ----KKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGD 933
                   GGS      +              S DE+D+ E    + + S  P L+     
Sbjct: 3198 PSPLSGPGGSSLLEKFELESGALTLPGGPAASGDELDKME---SSLVASELPLLI----- 3249

Query: 934  PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESD 993
               +    +  +L++ +Q +A + P Q  +  +      +   PA     P +   P   
Sbjct: 3250 --EDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLA 3307

Query: 994  APQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034
              QQ  S     +R P  P      +P   PA A + +  P
Sbjct: 3308 GSQQQLSLGLAGARQPGLPQPLMPTQP---PAHALQQRLAP 3345



 Score = 39.3 bits (90), Expect = 0.048
 Identities = 130/684 (19%), Positives = 227/684 (33%), Gaps = 127/684 (18%)

Query: 492  KSQQQQQQQQQQQ---------QQQQQQPMPRSSQEEKDEKE------KEKEAEKEEEKP 536
            K QQQQQQQQQQQ         QQQQQ P  +++Q    + +        +    ++  P
Sbjct: 3733 KLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSP 3792

Query: 537  EVENDKEDLL--------KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGR--ITRSM 586
            +     + +L        +++     G     ++ + ++ R  ++ Q  ++G+  +   +
Sbjct: 3793 QPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRL 3852

Query: 587  ANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGS-KT 645
                  ++    QQ   +A +   + S             L+ H       A+ +GS + 
Sbjct: 3853 VTAQQQQQQQQHQQQGSMAGLSHLQQS-------------LMSHSGQPKLSAQPMGSLQQ 3899

Query: 646  VSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEM 705
            + Q +      + +Q   + LQQ +   +++   ++++++      ++         ++ 
Sbjct: 3900 LQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQ 3959

Query: 706  EASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGP 765
            +       +++  ++ +  + N S T   P    +     G   P  P    +     GP
Sbjct: 3960 QQQQQQFQQQQ--QQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGP 4017

Query: 766  PTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEE 825
                        +P  +SEAT  P+     P      P    E    E     P   G+ 
Sbjct: 4018 TLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTP----ESMATEPGEVKPSLSGDS 4073

Query: 826  QKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGR 885
            Q       L V      +P   +        P + +   +   TA G    +   G S  
Sbjct: 4074 QL------LLVQPQPQPQPSSLQLQPPLRL-PGQQQQQVSLLHTAGGGSHGQLGSGSSSE 4126

Query: 886  ATT-----AKSSGAPQDSDSSATCSA----DEVDEAEGGDKNRLLSPRPS---------- 926
            A++     A+ S +  D   S T +       + E    +      P+P           
Sbjct: 4127 ASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLP 4186

Query: 927  ---LLTPTGDPRA-------------NASPQKPLDL------KQLKQRAAA--IPPIQVT 962
               ++   G  RA             + SPQ+   L      +QL+Q  A    PP Q  
Sbjct: 4187 GVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEP 4246

Query: 963  KVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP---GSSPRGKSRSPAPPADKEAEK 1019
                 P +     +P     P PQ        P Q    G  P+G  R PAPP    +  
Sbjct: 4247 GTQTSPLQGLLGCQPQLGGFPGPQT------GPLQELGAGPRPQGPPRLPAPPG-ALSTG 4299

Query: 1020 PVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGL 1079
            PV  P         P  PP   S    P  P ++   S   P  +      PG P P G 
Sbjct: 4300 PVLGPVH-------PTPPP---SSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQG- 4348

Query: 1080 HDTARPVLPRPPTISNPPPLISSA 1103
                       PT+  PP  +S A
Sbjct: 4349 -----------PTLEPPPGRVSPA 4361



 Score = 36.6 bits (83), Expect = 0.31
 Identities = 66/250 (26%), Positives = 90/250 (36%), Gaps = 22/250 (8%)

Query: 1518 PVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREP--TPRLQEGSLSSSKASQDRK 1575
            P + P+   P  SP   E H +P     P  SPV   EP  +P+ +E  LS    S++  
Sbjct: 786  PHLSPQAEGPHLSPQPEELHLSPQTEE-PHLSPVP-EEPCLSPQPEESHLSPQ--SEEPC 841

Query: 1576 LTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLD 1635
            L+  P E   SP    P   P P  P E       G       +PL F P   P   PL 
Sbjct: 842  LSPRPEESHLSPELEKPPLSPRPEKPPEE-----PGQCPAPEELPL-FPPPGEPSLSPLL 895

Query: 1636 AAAAYYLPRH--LAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATA 1693
               A   P    L+P P    L P       P     +     ++  IT+      +   
Sbjct: 896  GEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLG 955

Query: 1694 MAQRADMLRGLSPRESSLALNYAAGP------RGIIDLSQVPHLPVLVPPTPGTPATAMD 1747
              +     +G S  ES LA      P          D   VP  P+++PP+PG+P     
Sbjct: 956  ELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVP--PMILPPSPGSPVGPAS 1013

Query: 1748 RLAYLPTAPQ 1757
             +   P  PQ
Sbjct: 1014 PILMEPLPPQ 1023



 Score = 35.8 bits (81), Expect = 0.53
 Identities = 102/459 (22%), Positives = 158/459 (34%), Gaps = 85/459 (18%)

Query: 720  EAEATVNNSSDTESIPSPHTEAAKDTGQNGPKP-----PATLGADG---PPPGPPTPPPE 771
            E  A V +      + SP T A   T    P P     P  +G      P P P  PPP 
Sbjct: 2505 ELHAKVPSGQPPNFVRSPGTGAFVGT----PSPMRFTFPQAVGEPSLKPPVPQPGLPPPH 2560

Query: 772  DI-----PAPTEPTPASE----ATGAPTPPPAPPSPSA-------------PPPVVPKEE 809
             I     P PT   P S     ATG   P  +P  PS+             PP V+P   
Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPA 2620

Query: 810  KE-----------EETAAAPPVEEGEEQKPPAAEELAV-DTGKAEEPVKSECTE---EAE 854
             +           + +    PVE+ E+        LA  +    ++P  S  ++   E +
Sbjct: 2621 PDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQ 2680

Query: 855  EGPAKGKDAEAAEATAEGALKAEKKEGGS--GRATTAKSSGAPQDSDSSATCSADEVDEA 912
                + ++    +      L+ EK+   +  G      S GA   S +    S  +   A
Sbjct: 2681 RQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFA 2740

Query: 913  EGGDKNRLLSPRPSLLT-PTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPRED 971
               DK+ L+   PS L+ P   P +      P D +  +    A P        +     
Sbjct: 2741 GTQDKSSLVGLPPSKLSGPILGPGSF-----PSDDRLSRPPPPATPSSMDVNSRQLVGGS 2795

Query: 972  AAPTKPAP-PAPPPPQNLQPESDAPQQPGSSPRGK----SRSPAPPADKEAEKPVFFPAF 1026
             A  + AP P   P Q  Q +    QQ  ++   +    +R P+ P  +   + +  P  
Sbjct: 2796 QAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSP-L 2854

Query: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHA-----PDPSAF-SYAPPGHP------ 1074
            A  + +LPG        +P P  P + I+   +      P  + F    PP  P      
Sbjct: 2855 AGISTRLPGPG----EPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVS 2910

Query: 1075 ------LPLGLHDTARPVLPRPPTISNPPPLISSAKHPS 1107
                   P GL   A   LP     + P P ++++ HP+
Sbjct: 2911 EDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPT 2949



 Score = 35.4 bits (80), Expect = 0.70
 Identities = 52/174 (29%), Positives = 64/174 (36%), Gaps = 22/174 (12%)

Query: 61  PQRRRPSLLSEFQPGNERSQELHL-RPESHSYL-PELGKSEMEFIESKRPRLELLPDPLL 118
           P+  R S   E  P +   + LHL RP   S L P   +S +       P  E  P   L
Sbjct: 462 PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS------PPPESSPFSPL 515

Query: 119 RPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPP------SPPHTDPELELVPP----RLS 168
             SPL    +   S  L    S   +  P+SPP      SPP    EL   PP    RLS
Sbjct: 516 EESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPP--PEELPTSPPPEASRLS 573

Query: 169 KEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESK 222
                  M     E  M      +  +     EE    PP  E P+SPPP  S+
Sbjct: 574 PPPEESPMSPPPEESPMSPPP--EASRLFPPFEESPLSPPPEESPLSPPPEASR 625



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 27/103 (26%), Positives = 37/103 (35%), Gaps = 2/103 (1%)

Query: 120 PSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRV 179
           P PL    +P G   +  +  L   L    P  PP  +  L   PP  S         R+
Sbjct: 409 PGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLS-PPPEESPTSPPPEASRL 467

Query: 180 DREIT-MVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIES 221
                 +    + +     + LEE    PP  E P+SPPP  S
Sbjct: 468 SPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESS 510



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 90/391 (23%), Positives = 121/391 (30%), Gaps = 65/391 (16%)

Query: 1900 PAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSG 1959
            P     P  H    G L    PTL+   L  KE   V       A  G +     P   G
Sbjct: 3999 PGMPAKPLQHFSSPGALG---PTLL---LTGKEQNTVDPAVSSEATEGPSTHQGGPLAIG 4052

Query: 1960 LEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASAS-DPHREKTQ 2018
              P S     +EP  + P +SG + +              P P   P+S    P      
Sbjct: 4053 TTPESM---ATEPGEVKPSLSGDSQLLLV----------QPQPQPQPSSLQLQPPLRLPG 4099

Query: 2019 SKPFSIQELELRSLGYHG---SSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075
             +   +  L     G HG   S  S E       ++ PS++        L +   S  + 
Sbjct: 4100 QQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS--------LGDQPGSMTQN 4151

Query: 2076 ELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQ---HISE 2132
             L P+QP            P         P   P+LQ+  G+ G   + T+ Q    +  
Sbjct: 4152 LLGPQQP--------MLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQG 4203

Query: 2133 VITQDYTRHH-----PQQLSAPL------------PAPLYSFPGASCPVLD--LRRPPSD 2173
            V+ ++    H      QQL A L              P Y  PG     L   L   P  
Sbjct: 4204 VLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQL 4263

Query: 2174 LYLPPPDHGAPAR--GSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSA 2231
               P P  G        P  +G  R P P      G     + P  PP    EP      
Sbjct: 4264 GGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL 4323

Query: 2232 VYPLLYRDGE-QTEPSRMGSKSP-GNTSQPP 2260
              P      E Q  P+  G+  P G T +PP
Sbjct: 4324 PSPSSQLPTEAQLPPTHPGTPKPQGPTLEPP 4354



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 40/123 (32%), Positives = 51/123 (41%), Gaps = 11/123 (8%)

Query: 47  RDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQE---LHLRPESHSYLPELGKSEMEFI 103
           R   SHLSP     P   RP    E +PG   + E   L   P   S  P LG+  +   
Sbjct: 845 RPEESHLSPELEKPPLSPRPEKPPE-EPGQCPAPEELPLFPPPGEPSLSPLLGEPALS-- 901

Query: 104 ESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEP-VSPPSPPHTDPELEL 162
           E   P L  LP+ L    PL  +G+P+ S  L     L   L P ++  +PP   P  EL
Sbjct: 902 EPGEPPLSPLPEEL----PLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGEL 957

Query: 163 VPP 165
             P
Sbjct: 958 EYP 960



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 115/501 (22%), Positives = 166/501 (33%), Gaps = 96/501 (19%)

Query: 727  NSSDTESIP----SPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPA-PTEPTP 781
            +SS  +S P    SP  ++ +  G   P+P       G P  P T      P+ PT PT 
Sbjct: 1937 SSSPMDSYPGLCQSPFLDSRERGGFFSPEP-------GEPDSPWTGSGGTTPSTPTTPTT 1989

Query: 782  ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEET---AAAPPVEEGEEQKPPAAEELAVDT 838
              E  G           S     + + EK+EE    +   PV       P   ++    +
Sbjct: 1990 EGEGDGL----------SYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWS 2039

Query: 839  GKAEEPVKS-ECTEEAEEGP--AKGKDAEAA------EATAEGALKAEKKEGGSGRATTA 889
             + ++ +K       A++ P   K KD  AA      +  AE  +  + K G   R T  
Sbjct: 2040 SRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDR 2099

Query: 890  KS-----------------SGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTG 932
             +                 + AP     S T  A     A+G      L P      P G
Sbjct: 2100 PALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADG-----FLKP------PAG 2148

Query: 933  DPRANASPQKPLDLKQLKQRAAAIP---PIQVTKVH--EPPREDAAPTKPAPPAPPPPQN 987
                  SP + L LK   Q  A +P   P  +   +  EP    A PT P  P+P     
Sbjct: 2149 SVPGPDSPGE-LFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPA 2207

Query: 988  LQPESDAPQQPGSSPRGK--SRSPAPPADKEAEKPVFFPAFAAEAQKL--PGDPPC--WT 1041
              P   A  +PG+   G+  +  P  P  + +    F          L  P  P      
Sbjct: 2208 QPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGK 2267

Query: 1042 SGLPFPVPP-----REVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP 1096
            +  P   PP     R+ ++        S+ SY PP     LG  D+              
Sbjct: 2268 ASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPN----LGFVDSPSSGTHLGGLELKT 2323

Query: 1097 PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLP---MDPKKLA 1153
            P +  +   P     Q+   S G+ ++   P    A AP  P    +  P    DP    
Sbjct: 2324 PDVFKAPLTPRA--SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDP---- 2377

Query: 1154 PFSGVKQEQLSPRGQAGPPES 1174
                  Q  L+PR Q  PPES
Sbjct: 2378 ----YAQPPLTPRPQPPPPES 2394



 Score = 34.3 bits (77), Expect = 1.6
 Identities = 73/301 (24%), Positives = 102/301 (33%), Gaps = 52/301 (17%)

Query: 1816 PIWRPGTEQSSGSSGSSGGGG-------GSSSRPASHSHAHQHSPIS------PRTQDAL 1862
            P+  PG +Q   S   + GGG       GSSS  +S  H      +S        TQ+ L
Sbjct: 4094 PLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLL 4153

Query: 1863 QQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTL------ 1916
              +  +L         T  +P  P  +  +    P              L G L      
Sbjct: 4154 GPQQPMLERPMQNN--TGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQL 4211

Query: 1917 --------DGVYPTLMEPVLLPKEAPRVARP-ERPRADTG--HAFLAKPPARSGLE-PAS 1964
                      +   LM+  L   +A R   P + P   T      L   P   G   P +
Sbjct: 4212 RHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQT 4271

Query: 1965 SPSK--GSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPF 2022
             P +  G+ PRP  PP       A +    L P H +P    PP+S  +P R      P 
Sbjct: 4272 GPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTP----PPSSPQEPKRPSQLPSPS 4327

Query: 2023 SIQELELRSLGYHGSSYSPEG--VEP----VSPVSS--PSLTHDKGL-----PKHLEELD 2069
            S    E +    H  +  P+G  +EP    VSP ++        KGL     P +L E  
Sbjct: 4328 SQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQ 4387

Query: 2070 K 2070
            K
Sbjct: 4388 K 4388



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 15/17 (88%), Positives = 15/17 (88%)

Query: 490  RGKSQQQQQQQQQQQQQ 506
            R K QQQQQQQQQQQQQ
Sbjct: 3596 RNKQQQQQQQQQQQQQQ 3612



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 69/310 (22%), Positives = 101/310 (32%), Gaps = 41/310 (13%)

Query: 750  PKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEE 809
            P PP +  A  PP   P+ P   +PA   P   S +    TP P       P PV P+ +
Sbjct: 2389 PPPPESCCAL-PPRSLPSDPFSRVPA--SPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQ 2445

Query: 810  KEEETAAAPPVEEGEE-----QKPPAAE--ELAVDTGKAEEPVKSECTEEAEEGPAKGKD 862
              +  +  P   +  +      KPP  +  E+A   G             A      G  
Sbjct: 2446 SPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSL-----------AHTSLGAGGF 2494

Query: 863  AEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLS 922
              A  A   G L A+   G       +  +GA   + S    +     +A G    +   
Sbjct: 2495 PAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFT---FPQAVGEPSLKPPV 2551

Query: 923  PRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAI-------PPIQVTKVHEPPREDAAPT 975
            P+P L  P G   ++  P   L   Q      A         P+  +          +P 
Sbjct: 2552 PQPGLPPPHG-INSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPL 2610

Query: 976  KPAPPAPPPPQNLQPESDAPQ-QPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLP 1034
            +P    PPP     P+   P    G+S R    SP     ++ E P      +    +LP
Sbjct: 2611 RPPSVLPPP----APDGSLPYLSHGASQRSGITSPV----EKREDPGTGMGSSLATAELP 2662

Query: 1035 GDPPCWTSGL 1044
            G      SGL
Sbjct: 2663 GTQDPGMSGL 2672



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 3/45 (6%)

Query: 474  KKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQE 518
            +K +   + +   YR +   QQQQQQQQQQQQQQ    +  S  +
Sbjct: 3582 RKQQKEHTNLMAEYRNK---QQQQQQQQQQQQQQHSAVLALSPSQ 3623


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 266/1240 (21%), Positives = 442/1240 (35%), Gaps = 255/1240 (20%)

Query: 59   IQPQRRRPSLLSEFQPGNERSQEL---HLRPESHSYLP----ELGKSEMEFIESKRPRLE 111
            + P+  +   LSE  P  E S ++    L PES   L      LGK EM  +        
Sbjct: 1189 VSPEDTQSLSLSEESPSKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSH 1248

Query: 112  LLPDPLLRPSPLLATGQP--------AGSEDLTKDRSLTGKLEPVSPPSP---------- 153
                P+  P P  AT  P        +   D+T D      L+  SP S           
Sbjct: 1249 HTA-PMSVPEPHAATASPPTDGTTRYSAQTDITDD-----SLDRKSPASSFSHSTPSGNG 1302

Query: 154  -----PHTDPELELVPPRLSKEELIQNMDRVDREITMV--EQQISKLKKKQQQLEEEAAK 206
                   T P+  ++ P  S  +  +++     E   +  E ++  LK +  + ++E   
Sbjct: 1303 KYLPGAITSPDEHILTPDSSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKE--- 1359

Query: 207  PPEPEKPVSPPPIES-KHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQ 265
             PEP+  V     ++ +H+ +V+       +K EA H   E +  Q +  L  +  D  Q
Sbjct: 1360 -PEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQ-DKALEQKGRDLEQ 1417

Query: 266  YHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLME----AWEKKVERIENNPR 321
                ++      +      + ++ A +Q + K  +  D+ +E    A E+K + +E   +
Sbjct: 1418 KDTALEQKDKALEPKDKDLEEKDKALEQ-KDKIPEEKDKALEQKDTALEQKDKALEPKDK 1476

Query: 322  RRAKESKVREYYEKQFPEIRKQRELQERMQS-----------RVGQRGSGLSMSAARSEH 370
               ++ +V E  EK  PE  K + L ++++S            +  R    +  A   +H
Sbjct: 1477 DLEQKDRVLEQKEK-IPE-EKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKH 1534

Query: 371  EVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMN 430
            +  E  D +SE+++   + +  A+      +A +Q I+ +  N    +   + ++ +   
Sbjct: 1535 QAQEQKDKVSEKKDQALEQKYWAL--GQKDEALEQNIQALEENHQTQEQESLVQEDKTRK 1592

Query: 431  MWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRR 490
                +EK   + K M+       + + LE+            TK     +SLV+      
Sbjct: 1593 PKMLEEKSPEKVKAMEEK-----LEALLEK------------TKALGLEESLVQE----- 1630

Query: 491  GKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN----DKEDLL 546
            G++++Q+++  + Q   Q+      ++EE   ++KE     E+  PE +N     +ED+ 
Sbjct: 1631 GRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRYWRGREDVA 1690

Query: 547  KEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELAS 606
             E+  DT   +   +  V        + QG R                   P  + E  S
Sbjct: 1691 LEQ--DTYWRELSCERKVWFP--HELDGQGAR-------------------PHYTEERES 1727

Query: 607  MELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFY-FNYKKRQNLDEI 665
              L+E     ++E E     L EH            S   S  K+F   + +K   ++  
Sbjct: 1728 TFLDEG---PDDEQEVP---LREHATR---------SPWASDFKDFQESSPQKGLEVERW 1772

Query: 666  LQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATV 725
            L +  + +  E     K  ++P       A PP +  + + ++   G E  + +     +
Sbjct: 1773 LAESPVGLPPEE--EDKLTRSPFEIISPPASPPEMVGQRVPSA--PGQESPIPD--PKLM 1826

Query: 726  NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPED-IPAP-------T 777
             +  +  + PS   +      ++ P PPA L    P PGPPTP PE   PAP        
Sbjct: 1827 PHMKNEPTTPSWLADIPPWVPKDRPLPPAPL---SPAPGPPTPAPESHTPAPFSWGTAEY 1883

Query: 778  EPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK-PPAAEELAV 836
            +   A+   GA      P SP        + E+EEE  A  P +     K P A++  A 
Sbjct: 1884 DSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREEEGRAEAPDKSSHSSKVPEASKSHAT 1943

Query: 837  DTGKAEEPVKSECTEEAEE-----------------GPAKGKDAEAAEATAEGALKAEKK 879
               +  EP + E T   +E                 GPA         A  +       K
Sbjct: 1944 TEPEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWPPCLSTK 2003

Query: 880  EGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR--------PSLLTPT 931
            E  +GR T+A+   +   S  S    +D    +        + PR        PSL  P 
Sbjct: 2004 EAAAGRNTSAEKELSSPISPKS--LQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPA 2061

Query: 932  GDPRA---NASPQKPL--DLKQLKQRAAAIPPIQVTKVH---------------EPPRED 971
              PRA   +  P  PL  ++        +  P +  + H               E P ++
Sbjct: 2062 VPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKE 2121

Query: 972  AAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQ 1031
            A    P  P P     L PE++A   P   P      PA P+       + FPA A    
Sbjct: 2122 AQSPSPPHPIPMGSPTLWPETEAHVSP---PLDSHLGPARPS-------LDFPASAFGFS 2171

Query: 1032 KLPGDPPCWTSGLPFPVPPR-------------------------------EVIKAS--- 1057
             L   PP     LP P  PR                               EV KA    
Sbjct: 2172 SLQPAPP----QLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLD 2227

Query: 1058 ---PHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKH---PSV--L 1109
               P  P PS+     PG PL   L   A P L    +     P+ISS      PS+   
Sbjct: 2228 SSLPQLPSPSS-----PGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAA 2282

Query: 1110 ERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1149
            E++ G +  GM    H  +     +P  P ++ L L   P
Sbjct: 2283 EQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAP 2322



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 203/1027 (19%), Positives = 364/1027 (35%), Gaps = 139/1027 (13%)

Query: 309  WEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMS--AA 366
            WE KV  +++    + KE + ++   +Q  +  + +E+ E   + + Q+   L +   A 
Sbjct: 1342 WEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAV 1401

Query: 367  RSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDAD-QQRIKFINMNGLMADPMKVYKD 425
            + + +  E      EQ++   + +  A+ P    D D +++ K +       D +   KD
Sbjct: 1402 KQQDKALEQKGRDLEQKDTALEQKDKALEPK---DKDLEEKDKALEQK----DKIPEEKD 1454

Query: 426  RQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVR- 484
            + +      ++K+T  E   Q  K        LE+K   + VL        E  K+L + 
Sbjct: 1455 KAL------EQKDTALE---QKDKALEPKDKDLEQK---DRVLEQKEKIPEEKDKALDQK 1502

Query: 485  -RSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKE 543
             RS   +       + + +  +Q  + P  +   +E+ +K  EK+ +  E+K      K+
Sbjct: 1503 VRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKD 1562

Query: 544  DLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAE 603
            + L++           +++    +  KT   +   +    +  A E   E  +   ++  
Sbjct: 1563 EALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALG 1622

Query: 604  LASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSK----------TVSQCKNFY 653
            L    + E     +EE     + +++  +  S        +          T  +  N Y
Sbjct: 1623 LEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRY 1682

Query: 654  FNYKKRQNLDEILQQHKLKMEKE----RNARRKKKKAPAAASEEAAFPPVVEDEEME--- 706
            +  ++   L++     +L  E++         +  +       E+ F     D+E E   
Sbjct: 1683 WRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERESTFLDEGPDDEQEVPL 1742

Query: 707  ---------ASGVSGNEEEMVEE--------AEATVNNSSDTE--------SIPSPHTEA 741
                     AS     +E   ++        AE+ V    + E         I SP    
Sbjct: 1743 REHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASP 1802

Query: 742  AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAP 801
             +  GQ  P  P   G + P P P   P       T    A      P   P PP+P +P
Sbjct: 1803 PEMVGQRVPSAP---GQESPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAPLSP 1859

Query: 802  PPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGK 861
             P  P    E  T A  P   G  +       +     + E    S   ++  +   + +
Sbjct: 1860 APGPPTPAPESHTPA--PFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGERE 1917

Query: 862  DAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLL 921
            +   AEA  + +  ++  E     ATT      P+  + +          A+  ++  L 
Sbjct: 1918 EEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQYADIYEQMMLT 1977

Query: 922  SPRPSLLTPTGDPRANASPQKP--LDLKQL---------KQRAAAIPPIQVTKVHEPPRE 970
               P+   PT +P   A+   P  L  K+          K+ ++ I P +  +   P   
Sbjct: 1978 GLGPA--CPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKELSSPISP-KSLQSDTPTFS 2034

Query: 971  DAAPTKP-APPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAE 1029
             AA   P  PP P P  +++P    P  P  +P   S+ P+PP +             + 
Sbjct: 2035 YAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPI-LSKGPSPPLNGNI-------LSCSP 2086

Query: 1030 AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR 1089
             ++ P       S         E+ K +   P+  A S +PP HP+P+G      P L  
Sbjct: 2087 DRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPP-HPIPMG-----SPTL-W 2139

Query: 1090 PPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDP 1149
            P T ++  P + S   P+                L  P S    + + P    LP P +P
Sbjct: 2140 PETEAHVSPPLDSHLGPA-------------RPSLDFPASAFGFSSLQPAPPQLPSPAEP 2186

Query: 1150 KKLAP-----FSGVKQEQLSPRGQAGPP------ESLGVPTAQEA-SVLRGTALGSVPGG 1197
            +  AP     FSG +   L+P    GPP      E L V  A    S L      S PG 
Sbjct: 2187 RS-APCGSLAFSGDRALALAP----GPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGA 2241

Query: 1198 SITKGIPSTRVPSDSAITYRGSITHGTP--ADVLYKGTITRIIGEDSPSRLDRGREDSLP 1255
             +   +P    P+  A++   S    TP  + V  + + +    E     LD G E   P
Sbjct: 2242 PLLSNLPR---PASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGME---P 2295

Query: 1256 KGHVIYE 1262
              H +++
Sbjct: 2296 AAHSLWD 2302



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 142/663 (21%), Positives = 210/663 (31%), Gaps = 117/663 (17%)

Query: 729  SDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGA 788
            S  E+    +T A K+   + P  P +L +D P           +P   EP P+ E +  
Sbjct: 2001 STKEAAAGRNTSAEKEL--SSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLT 2058

Query: 789  P--TPPPAPPSPSAPPPVVPKE--EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEP 844
            P   PP AP     P P +         +  +  P E G      +  +  ++ G  E+P
Sbjct: 2059 PPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQP 2118

Query: 845  VKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEG---------GSGRATTAKSSGAP 895
             K   +         G      E  A  +   +   G          S    ++     P
Sbjct: 2119 EKEAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPP 2178

Query: 896  QDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-RANASPQKPLDLKQLKQRAA 954
            Q    +   SA     A  GD+   L+P P   T   +      +P     L QL   ++
Sbjct: 2179 QLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSS 2238

Query: 955  AIPPI--QVTKVHEPPREDAAPTKPAPPA-PPPPQNLQPESDAPQQ------PGSSPRGK 1005
               P+   + +   P   + + ++   P      +   P  +A +Q      PG  P   
Sbjct: 2239 PGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAH 2298

Query: 1006 SR------SPAPPADKEAEKPVFFPAFAAEAQKLPGDP-----PCWTS--------GLPF 1046
            S       SPAPPA  +           A A  LPGD      PC             PF
Sbjct: 2299 SLWDLTPLSPAPPASLDLA--------LAPAPSLPGDMGDGILPCHLECSEAATEKPSPF 2350

Query: 1047 PVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLP---------------RPP 1091
             VP  +     P    P+     PPG P P    +      P               RP 
Sbjct: 2351 QVPSEDCAANGPTETSPN-----PPG-PAPAKAENEEAAACPAWERGAWPEGAERSSRPD 2404

Query: 1092 TISNPP----PLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPM 1147
            T+ +P     P   S   PS    ++ A  QG + +      E + + + P    LP  +
Sbjct: 2405 TLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPP---LPPSI 2461

Query: 1148 DPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTR 1207
            D + L+       E++   G+ G    +G P         GT  G  P   +T   P T 
Sbjct: 2462 DDRDLST------EEVRLVGRGGR-RRVGGP---------GTTGGPCP---VTDETPPTS 2502

Query: 1208 VPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGH 1267
              SDS  +   S     P +            E+ PS       DS   G  +   K G 
Sbjct: 2503 A-SDSGSSQSDS---DVPPET-----------EECPSITAEAALDSDEDGDFLPVDKAGG 2547

Query: 1268 VLSYEG---GMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGR 1324
            V        G       + D R S   P    A         GRV R      ++G +GR
Sbjct: 2548 VSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGR 2607

Query: 1325 AIP 1327
              P
Sbjct: 2608 RAP 2610



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 92/395 (23%), Positives = 136/395 (34%), Gaps = 84/395 (21%)

Query: 726  NNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT-----PPPEDIPAPTEPT 780
            +++SD+E       +  K+     P PP  +    P   P T     PP +    P  P+
Sbjct: 2103 DSTSDSELEKGAREQPEKEA--QSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPS 2160

Query: 781  ---PASEATGAPTPPPAPP---SPSAP---------------------PPVVPKEEKEEE 813
               PAS A G  +  PAPP   SP+ P                     PP   + ++  E
Sbjct: 2161 LDFPAS-AFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLE 2219

Query: 814  TAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEG- 872
               AP ++    Q P  +   A        P+ S     A    ++G  +EA        
Sbjct: 2220 VTKAPSLDSSLPQLPSPSSPGA--------PLLSNLPRPASPALSEGSSSEATTPVISSV 2271

Query: 873  ------ALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926
                  +L+A ++E G        ++ +  D    +      +D A        L+P PS
Sbjct: 2272 AERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLA--------LAPAPS 2323

Query: 927  LLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAA---PTKPAP---- 979
            L    GD         P  L+  +       P QV      P ED A   PT+ +P    
Sbjct: 2324 LPGDMGDGIL------PCHLECSEAATEKPSPFQV------PSEDCAANGPTETSPNPPG 2371

Query: 980  PAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPC 1039
            PAP   +N +  +    + G+ P G  RS  P      E+PV  PA  +      G PP 
Sbjct: 2372 PAPAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPV-CPAGGS------GGPPS 2424

Query: 1040 WTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHP 1074
              S      P     +  PH  + S     PP  P
Sbjct: 2425 SASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPP 2459



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 140/624 (22%), Positives = 206/624 (33%), Gaps = 138/624 (22%)

Query: 1518 PVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSL---SSSKASQDR 1574
            P + P    PR +P+  +    P  G++   SP   R P+P+    S    S+S +  ++
Sbjct: 2055 PSLTPPAVPPR-APILSKGPSPPLNGNILSCSP-DRRSPSPKESGRSHWDDSTSDSELEK 2112

Query: 1575 KLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPL 1634
                 P + A+SP        PHPI      L   +      +H+    D    P    L
Sbjct: 2113 GAREQPEKEAQSPSP------PHPIPMGSPTLWPET-----EAHVSPPLDSHLGPARPSL 2161

Query: 1635 DAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAM 1694
            D  A+ +    L P P  P L  P   R  P                           ++
Sbjct: 2162 DFPASAFGFSSLQPAP--PQLPSPAEPRSAP-------------------------CGSL 2194

Query: 1695 AQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPT 1754
            A   D    L+P   +   +        +++++ P L   +P  P   +     L+ LP 
Sbjct: 2195 AFSGDRALALAPGPPTRTRHDE-----YLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLP- 2248

Query: 1755 APQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEH 1814
                   R +S  LS G  +  T P  +S +ER                           
Sbjct: 2249 -------RPASPALSEGSSSEATTPVISSVAER--------------------------- 2274

Query: 1815 APIWRPGTEQSSGSSGSSGGGGGSSSRPASHS--HAHQHSPISPRTQD-ALQQRPSVLHN 1871
               + P  E +   SG    G      PA+HS       SP  P + D AL   PS+  +
Sbjct: 2275 ---FSPSLEAAEQESGELDPG----MEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGD 2327

Query: 1872 TGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPK 1931
             G  GI+       P  L   S ++  +P+    P+  C   G      PT   P   P 
Sbjct: 2328 MG-DGIL-------PCHL-ECSEAATEKPSPFQVPSEDCAANG------PTETSP-NPPG 2371

Query: 1932 EAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPV--SGHATIARTP 1989
             AP  A  E   A       A P    G E +S P     P   V P   SG    + +P
Sbjct: 2372 PAPAKAENEEAAACPAWERGAWP---EGAERSSRPDTLLSPEQPVCPAGGSGGPPSSASP 2428

Query: 1990 AKNLAPHHASPDP-----PAPPASASDPHREKTQSKPFSIQELEL------RSLGYHGSS 2038
                 P   + +P        P+  + P       +  S +E+ L      R +G  G++
Sbjct: 2429 EVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTT 2488

Query: 2039 YSP----EGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPG---PVKLGGEA 2091
              P    +   P S   S S   D  +P   EE      E  L   + G   PV   G  
Sbjct: 2489 GGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGV 2548

Query: 2092 AHLPHLR------PLPESQPSSSP 2109
            +   H R      PLP+  P  SP
Sbjct: 2549 SGTHHPRPGHDPPPLPQPDPRPSP 2572



 Score = 41.6 bits (96), Expect = 0.010
 Identities = 84/449 (18%), Positives = 162/449 (36%), Gaps = 47/449 (10%)

Query: 475 KNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEE 534
           ++E  K L +   + +  S++  ++  + ++ + +      +++ K  K+K  +   +E+
Sbjct: 349 RSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEK 408

Query: 535 KPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEE 594
             ++E  K+   KEK +        +K+    + +K A  + +RK              +
Sbjct: 409 ISKLEEKKD---KEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLK 465

Query: 595 AITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYF 654
             TP+    L   ++    +         +K L    +   A    V   T+S  +    
Sbjct: 466 PFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVL 525

Query: 655 NYKK--RQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSG 712
           +  +   Q+ +E+ ++ +  + ++R+     K  P   +EE      ++       G+ G
Sbjct: 526 SSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGL-G 584

Query: 713 NEEEMVEEAEAT-----VNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767
            EE +++E E          S D        TE  KDT +   +  A             
Sbjct: 585 QEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREA------------- 631

Query: 768 PPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQK 827
              E +P  TE    SE             P     V+ K E EE     P  EE E+  
Sbjct: 632 ---ERLPDRTEAREESE-------------PEVKEDVIEKAELEEMEEVHPSDEEEED-- 673

Query: 828 PPAAEELAVDTGKAEEPVK-SECTEEAEEGPAKGKDAEAAEATAEGALKA-EKKEGGSGR 885
             A +         +EP+K +  + EA  G   G   +A E      L +     G +  
Sbjct: 674 --ATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEH 731

Query: 886 ATTAKSSGAPQDSDSSATCSADEV-DEAE 913
            +  +    P  S++  T S +E+ DE E
Sbjct: 732 VSYIQDETIPGYSETEQTISDEEIHDEPE 760



 Score = 35.4 bits (80), Expect = 0.70
 Identities = 64/272 (23%), Positives = 96/272 (35%), Gaps = 49/272 (18%)

Query: 730  DTESIPSPHTEAAKDTGQNG-----PKPPATLGADGPPPG---PPTPPPEDIPAPTEPTP 781
            +TE  PS   EAA D+ ++G      K     G   P PG   PP P P+  P+P  P  
Sbjct: 2518 ETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDV 2577

Query: 782  ASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA 841
                      P    S S    V    EKE+          G+ +    A  L +   ++
Sbjct: 2578 CM------ADPEGLSSESG--RVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRS 2629

Query: 842  EEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEG--------------GSGRAT 887
              P K    + A   P + +      +T      AE+K+G              G    +
Sbjct: 2630 PTPGKGP-ADRASRAPPRPR------STTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALS 2682

Query: 888  TAKSSGAPQDSDSSAT---CSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPL 944
            +  SSGAP   D +     CS       +  D +     R S    +G+  AN  P + +
Sbjct: 2683 SKGSSGAPVYVDLAYIPNHCS------GKTADLDFFRRVRASYYVVSGNDPANGEPSRAV 2736

Query: 945  DLKQLKQRAAAIPPIQVTKVHEPPREDAAPTK 976
                L+ +A     +QVT +   P  D   T+
Sbjct: 2737 LDALLEGKAQWGENLQVTLI---PTHDTEVTR 2765



 Score = 33.5 bits (75), Expect = 2.7
 Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 12/76 (15%)

Query: 805 VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAE 864
           V K  K EE      VEEG ++   A  ELA +  K E+  K    E +E+ P K    E
Sbjct: 331 VSKLAKREEV-----VEEGAKE---ARSELAKELAKTEKKAK----ESSEKPPEKPAKPE 378

Query: 865 AAEATAEGALKAEKKE 880
             +  +  ALKAEK++
Sbjct: 379 RVKTESSEALKAEKRK 394


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 135/550 (24%), Positives = 193/550 (35%), Gaps = 87/550 (15%)

Query: 705  MEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPG 764
            + A+ +   +  + +   +    S  T+S P+P   AA    Q    PP+ +     P G
Sbjct: 542  LSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDG 601

Query: 765  ---PPTPP---------------PEDIPAPTEPTPASEATGAPTPPPAPPSP-SAPPPVV 805
               P TP                P+  PA + P P          PP  P+P +A PP  
Sbjct: 602  LVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQA 661

Query: 806  PKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG----------------KAEEPVKSEC 849
               +     A++P  E+    +PP+A   A+ T                  AE P  S  
Sbjct: 662  TTPQPSPGLASSP--EKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVP 719

Query: 850  TEEAEEGPAKGKDAEAAEATAEGA-LKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADE 908
                   P   +D   A   A+GA L  +  +  +  A   +   A        + S   
Sbjct: 720  ASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSL 779

Query: 909  VDEAEGGDKNRLLSPRPSL--LTPTGDPRANASP--QKPLDLKQLKQRAAAIPPIQVTKV 964
              +A  GD   L SP P+     P   P++ + P  + PL      Q    +P I V + 
Sbjct: 780  PHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQN 839

Query: 965  H---EPPREDAAPTKPAPPAPP-PPQNLQPESDAPQQP-----------GSSPRGKSRSP 1009
                 PP  + APT P PP PP  PQ+  PE   P  P            SS    SR P
Sbjct: 840  QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLP 899

Query: 1010 AP-PADKEAEKPVFFPAFAAEAQKLPGDPPCW----TSGLPFPVPPRE---VIKASPHAP 1061
            AP P+D + + P      +    K P  PP          P P PPR    V    P  P
Sbjct: 900  APTPSDFQLQFPP-----SQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALP 954

Query: 1062 DPSAFSYAPPGHPLPLG--LHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQG 1119
             P A       H +P G  L + A      P T ++  PL S A            +  G
Sbjct: 955  QPKAL--LERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPA---------ASVLVSG 1003

Query: 1120 MSVQLHVPYSEHAKAPVGPVTMGLP--LPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGV 1177
             +         HA AP      GLP  LP + K  A  S +    ++    +GP +  G+
Sbjct: 1004 QAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFA--SNLPTLNVAKAASSGPGKPSGL 1061

Query: 1178 PTAQEASVLR 1187
                + S L+
Sbjct: 1062 QYESKLSGLK 1071



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 105/458 (22%), Positives = 161/458 (35%), Gaps = 74/458 (16%)

Query: 684  KKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMV----EEAEATVNNSSDTESIPSPHT 739
            ++ P A + +AA PP     +  + G++ + E++V      A  T   + D+  +  P  
Sbjct: 645  QQPPQAPTPQAAAPPQATTPQ-PSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQE 703

Query: 740  EAAKDTGQNGP--KPPATLGADGPPP----------------GPPTPPPEDIPAPTEPTP 781
             + +     GP    PA++    PPP                GP  P  +  PAP    P
Sbjct: 704  RSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIP 763

Query: 782  ASEATGAPTPPPAPPSPSAPP----PVVPKEEKEEETAAAPPVEEGEEQKPPAAEEL-AV 836
            A+     P P  +P  P   P    P +P         + PP       +PP+   L   
Sbjct: 764  AAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH-PTRPPSRPPSRPQSVSRPPSEPPLHPC 822

Query: 837  DTGKAEEPVKSECTEEAEEG--PAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA 894
               +A   +      + + G  P     A  A    +  L+ + +           +   
Sbjct: 823  PPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQ---PPEGPLPPAPHL 879

Query: 895  PQDSDSSATCSADEVDEAEGGDKNRLLSPRPS----LLTPTGDPRANASPQKPLDLKQLK 950
            P  S SSA  S+ E         +RL +P PS       P+  P  + SP  P  L  + 
Sbjct: 880  PPSSTSSAVASSSET-------SSRLPAPTPSDFQLQFPPSQGP--HKSPTPPPTLHLVP 930

Query: 951  QRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAP------QQPGSSPR- 1003
            + AA  PP        PPR     T P P  P P   L+     P       + G +P  
Sbjct: 931  EPAAPPPP--------PPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAA 982

Query: 1004 -------GKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKA 1056
                   G   SPA       + P   P   + A   P   P   +GLP P+ P E    
Sbjct: 983  PQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHA---PAPAPMAATGLP-PLLPAENKAF 1038

Query: 1057 SPHAPDPSAFSYAPPGHPLPLGL-HDTARPVLPRPPTI 1093
            + + P  +    A  G   P GL +++    L +PPT+
Sbjct: 1039 ASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTL 1076



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 52/177 (29%), Positives = 66/177 (37%), Gaps = 29/177 (16%)

Query: 742  AKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAP---PSP 798
            A D     P PPATL    PPP PP PPP        PT     T    PP AP   P  
Sbjct: 1326 ALDPVHQPPPPPATLKVAEPPPRPPPPPP--------PTGQMNGTVDHPPPAAPERKPLG 1377

Query: 799  SAPP-PVVPKEEKEEETAAAPPVEEG----------EEQKPPAAEELAVDTGKAEEPVKS 847
            +AP  P +P  +   E    P   EG              P   +E      +    V+ 
Sbjct: 1378 TAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVED 1437

Query: 848  ECTEEAEEGPAKGKDAEAAEAT------AEGALKAEKKEGGSGRATTAK-SSGAPQD 897
            E  +   +GP     A AA+ T      A G   A++++  S     A  SS +PQD
Sbjct: 1438 ELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQD 1494



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 78/329 (23%), Positives = 108/329 (32%), Gaps = 66/329 (20%)

Query: 1705 SPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHS 1764
            +P   + A   A  P+    L+  P   VL  P   TP   + + +     PQ      S
Sbjct: 650  APTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQ----ERS 705

Query: 1765 SSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQ 1824
              PLS  GP HL+ P                        S++ S       P   P T  
Sbjct: 706  QQPLSAEGP-HLSVPA-----------------------SVIVSAPPPAQDPA--PATPV 739

Query: 1825 SSGSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNT--GMKGIITAVE 1882
            + G+    G G  +    AS + A Q    +P         PS+ H    G    + +  
Sbjct: 740  AKGA----GLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPH 795

Query: 1883 PSTPTVLRSTSTSSPVRPAATFPPATHCP---LGGTLDGVY----------------PTL 1923
            P+ P     +   S  RP +  PP   CP      TL G++                PT 
Sbjct: 796  PTRPPSRPPSRPQSVSRPPSE-PPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTA 854

Query: 1924 -------MEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLV 1976
                   + P   P E P    P  P + T  A  +     S L PA +PS      P  
Sbjct: 855  PGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRL-PAPTPSDFQLQFP-- 911

Query: 1977 PPVSGHATIARTPAKNLAPHHASPDPPAP 2005
            P    H +    P  +L P  A+P PP P
Sbjct: 912  PSQGPHKSPTPPPTLHLVPEPAAPPPPPP 940



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 43/139 (30%), Positives = 58/139 (41%), Gaps = 20/139 (14%)

Query: 881  GGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASP 940
            GGS   T A++S +   S SS++ +A  +D  E G       P PS   P   P      
Sbjct: 1254 GGSPSVTWARASSSLSSSSSSSS-AASSLDADEDG-------PMPSRNRP---PIKTYEA 1302

Query: 941  QKPLDLK-QLKQRAAAIPPIQVTK---VHEPPREDA----APTKPAPPAPPPPQNLQPES 992
            +  + LK ++KQ A     +  T    VH+PP   A    A   P PP PPPP   Q   
Sbjct: 1303 RSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPP-PPPPPTGQMNG 1361

Query: 993  DAPQQPGSSPRGKSRSPAP 1011
                 P ++P  K    AP
Sbjct: 1362 TVDHPPPAAPERKPLGTAP 1380



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 86/371 (23%), Positives = 117/371 (31%), Gaps = 123/371 (33%)

Query: 1881 VEPSTPTVLRSTSTSSPV---RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVA 1937
            V+P+TP    +T  ++PV   +PA   PPA   PL   L    P   +P   P   P+ A
Sbjct: 603  VQPATPAA--ATGEAAPVLTVQPAPQAPPAVSTPLPLGLQ--QPQAQQPPQAP--TPQAA 656

Query: 1938 RPER---PRADTGHA------FLAKPPARSGLE--------------------------- 1961
             P +   P+   G A       L +PP+ +                              
Sbjct: 657  APPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHL 716

Query: 1962 --PAS----SPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHRE 2015
              PAS    +P    +P P  P   G     + P    +P       PAP   A+ P   
Sbjct: 717  SVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASP------APAPQIPAAAP--- 767

Query: 2016 KTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075
                                        ++   P SSPSL H   L       D  HL  
Sbjct: 768  ----------------------------LKGPGPSSSPSLPHQAPLG------DSPHLPS 793

Query: 2076 ELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVIT 2135
                + P            P  RP   S+P S P L   P  +    +  +       + 
Sbjct: 794  PHPTRPPS----------RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGI------FVI 837

Query: 2136 QDYTRHHPQQLSAPLPA--PLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGS----P 2189
            Q+       QL  P PA  P  + PG   P L  +  P +  LPP  H  P+  S     
Sbjct: 838  QN-------QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVAS 890

Query: 2190 HSEGGKRSPEP 2200
             SE   R P P
Sbjct: 891  SSETSSRLPAP 901



 Score = 36.6 bits (83), Expect = 0.31
 Identities = 102/462 (22%), Positives = 155/462 (33%), Gaps = 89/462 (19%)

Query: 796  PSPSAPPPVVPKEEKEEETAAAPPV------EEGEEQKPPAAEELAVDTGKAEEPVKSEC 849
            P P+ P P V  +  E++   +P          G +Q     ++   +    E+ +++E 
Sbjct: 63   PEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEA 122

Query: 850  ----------TEEAEEGPAKGKDAEAAEATAEG--ALKAEKKE----GGSGRATTAKSSG 893
                      T +  +G A    A  A A A G  AL     +     G     T ++  
Sbjct: 123  ELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQALV 182

Query: 894  APQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLL-TPTGDPRANASPQKPLDLKQLKQR 952
             PQD  + A      +     G  N  L P P L   P G P    +             
Sbjct: 183  PPQDVVNKALSVQPFLQPV--GLGNVTLQPIPGLQGLPNGSPGGATA------------A 228

Query: 953  AAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQP------GSSPRG-- 1004
               + PIQV  V +P      PT        P       +  P +P      G SP+G  
Sbjct: 229  TLGLAPIQV--VGQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAG 286

Query: 1005 ---KSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAP 1061
               +    A  A       VF  A AA A      P    SG P  V P   + +SP  P
Sbjct: 287  LVIQKNLSAAVATTLNGNSVFGGAGAASA------PTGTPSGQPLAVAPG--LGSSPLVP 338

Query: 1062 DPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNP------PPLISSAKHPSVLERQIGA 1115
             P+              LH T  P+ P+P  +  P      P   + A     ++ + GA
Sbjct: 339  APNVI------------LHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGA 386

Query: 1116 ISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQA--GPPE 1173
            + Q      ++ +    KA    V  G P P     +      KQ   +  G A   PP 
Sbjct: 387  LPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANV-----FKQPPATTTGAAPPQPPG 441

Query: 1174 SLGVPTA----QEASVLRGTALGSVPGGS--ITKGIPSTRVP 1209
            +L  P +     + S +   A   +PG +  +  G P+ ++P
Sbjct: 442  ALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLP 483


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 118/497 (23%), Positives = 175/497 (35%), Gaps = 95/497 (19%)

Query: 700  VEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGAD 759
            ++DEE E       EEE  +E E     +   E +P+   E AK      P PP T  A 
Sbjct: 361  LDDEEEEKK----EEEEKDKEGEEKEERAVAEEMMPAAEKEEAKL-----PPPPLTPPAP 411

Query: 760  GPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819
             PPP  P PPP   P P              PPP PP    P P  P           PP
Sbjct: 412  SPPP--PLPPPSTSPPPPL-----------CPPPPPPVSPPPLPSPP----------PPP 448

Query: 820  VEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKK 879
             +E +E+ PP          +   P+           P++  + EAA A  EG       
Sbjct: 449  AQEEQEESPPPVVPATCSRKRGRPPLT----------PSQRAEREAARAGPEGTSPPTP- 497

Query: 880  EGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANAS 939
                    +  + G P+DS + A  S   +          ++S R S +  T     +  
Sbjct: 498  ------TPSTATGGPPEDSPTVAPKSTTFLKNIRQFIM-PVVSARSSRVIKTPRRFMDED 550

Query: 940  PQKPLDLK---QLKQRAAAIPPI--QVTKVHEPPREDAAPTKPAPPAPPPPQN------- 987
            P KP  ++    L+      PP+  +   V  PPR   APT P+ P P P +        
Sbjct: 551  PPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPR---APTPPSTPVPLPEKRRSILREP 607

Query: 988  ----LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSG 1043
                     + P  P + P   + SP P     + +P+   A     Q  P +       
Sbjct: 608  TFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRA----PQFTPSEAHLKIYE 663

Query: 1044 LPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPR-PPTISNP------ 1096
                 PP    +A    P P+  S   P  P P  +  T    LPR  P ++ P      
Sbjct: 664  SVLTPPPLGAPEAPEPEPPPADDS---PAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS 720

Query: 1097 ----PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKL 1152
                P L +  +  + L + + A+   +  Q   P     + P  P  M    P++  ++
Sbjct: 721  PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMP---PLEKARI 777

Query: 1153 A-----PFSGVKQEQLS 1164
            A     P SGV+++  S
Sbjct: 778  AGVGSLPLSGVEEKMFS 794



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 94/376 (25%), Positives = 127/376 (33%), Gaps = 62/376 (16%)

Query: 750  PKPPATLGADGPPPGPP---TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVP 806
            P+PP +  A  P    P    PPP  +   T  TP S     P P P+PP P    P   
Sbjct: 1921 PRPPPSRWASPPLKTSPQLRVPPPTSVV--TALTPTSGELAPPGPAPSPPPPEDLGPDFE 1978

Query: 807  KEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAA 866
              E     +AA            AA  L  +  + EE V +     +  GP    + E++
Sbjct: 1979 DMEVVSGLSAA--------DLDFAASLLGTEPFQ-EEIVAAGAMGSSHGGPGDSSEEESS 2029

Query: 867  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 926
              T+             G A +A + GAP+          D VD+    +   +  PR  
Sbjct: 2030 -PTSRYIHFPVTVVSAPGLAPSA-TPGAPRIE------QLDGVDDGTDSEAEAVQQPRGQ 2081

Query: 927  LLTPTGD--PRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPA-PPAPP 983
               P+G    RA          +  +   + I    +  +  P    A P + + PPAPP
Sbjct: 2082 GTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPP 2141

Query: 984  PPQNLQPESDAPQQPGSSPRG------------KSRSPAPPADKEAEKPVF--------F 1023
                 QP       P    R              S  PAP   K A   +         F
Sbjct: 2142 LANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVF 2201

Query: 1024 PAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTA 1083
               A E + +P  PP        P+PP      SP AP     S+  P  PL LG+    
Sbjct: 2202 VKMAGEGEPVP--PPVKQP----PLPP----TISPTAPT----SWTLPPGPL-LGVLPVV 2246

Query: 1084 RPVLPRPPTISNPPPL 1099
              V P PP    PPPL
Sbjct: 2247 GVVRPAPP--PPPPPL 2260



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 46/161 (28%), Positives = 60/161 (37%), Gaps = 37/161 (22%)

Query: 966  EPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
            +PP +       AP    P QNL P    P +P S   G +  PAP +   A   V  P 
Sbjct: 1819 DPPLDTDVLVPGAPERHSPIQNLDP----PLRPDS---GSAPPPAPRSFSGARIKV--PN 1869

Query: 1026 FAAEAQKL----------PGDPPCWTSGLP------FPVPPREVIKASPHAPDPSAFSYA 1069
            ++   + L          PG P   T  +P      FP PPR   + SP AP P    +A
Sbjct: 1870 YSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWA 1929

Query: 1070 ------------PPGHPLPLGLHDTARPVLPRPPTISNPPP 1098
                        PP   +   L  T+  + P  P  S PPP
Sbjct: 1930 SPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPP 1970



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 83/341 (24%), Positives = 111/341 (32%), Gaps = 64/341 (18%)

Query: 1883 PSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERP 1942
            P  P    + S   P+ P +T PP   CP         P  + P  LP   P  A+ E+ 
Sbjct: 402  PPPPLTPPAPSPPPPLPPPSTSPPPPLCP-------PPPPPVSPPPLPSPPPPPAQEEQE 454

Query: 1943 RADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDP 2002
                     + PP    + PA+   K   P PL P        AR       P   SP  
Sbjct: 455  E--------SPPP----VVPATCSRKRGRP-PLTPSQRAEREAARA-----GPEGTSPPT 496

Query: 2003 PAPPASASDPHREKTQSKPFSIQELE-LRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGL 2061
            P P  +   P  +     P S   L+ +R             + PV  VS+ S    K  
Sbjct: 497  PTPSTATGGPPEDSPTVAPKSTTFLKNIRQF-----------IMPV--VSARSSRVIKTP 543

Query: 2062 PKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQ 2121
             + ++E      + E+ P    P+             P P   P  +P   + P     +
Sbjct: 544  RRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQ----EPAPVPSPPRAPTPPSTPVPLPEK 599

Query: 2122 RVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRP---------PS 2172
            R   L +          TR  P    AP P P  S P A  P    RRP         PS
Sbjct: 600  RRSILREPTFR--WTSLTRELPPPPPAPPPPPAPSPPPA--PATSSRRPLLLRAPQFTPS 655

Query: 2173 DLY-------LPPPDHGAPARGSPHSEGGKRSP-EPNKTSV 2205
            + +       L PP  GAP    P       SP EP   +V
Sbjct: 656  EAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAV 696



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 68/250 (27%), Positives = 89/250 (35%), Gaps = 68/250 (27%)

Query: 1911 PLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSG----LEPASSP 1966
            PLGG   G  P+   P  L    P V  P+ P           PP RS     L P   P
Sbjct: 1876 PLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPA----------PPRRSRRPSPLAPRPPP 1925

Query: 1967 SKGSEPRPL-------VPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQS 2019
            S+ + P PL       VPP +   T     +  LAP   +P PP PP        +    
Sbjct: 1926 SRWASP-PLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPP-PPEDLGPDFEDMEVV 1983

Query: 2020 KPFSIQEL--------------ELRSLGYHGSSYSPEGVE--------------PVSPVS 2051
               S  +L              E+ + G  GSS+   G                PV+ VS
Sbjct: 1984 SGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVS 2043

Query: 2052 SPSL--THDKGLPKHLEELD------KSHLEGELRPK-------QPGPVKLGGEAAHLPH 2096
            +P L  +   G P+ +E+LD       S  E   +P+        PG V+ G   A    
Sbjct: 2044 APGLAPSATPGAPR-IEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDR 2102

Query: 2097 LRPLPESQPS 2106
             RP PE  PS
Sbjct: 2103 ARP-PEDLPS 2111



 Score = 37.4 bits (85), Expect = 0.18
 Identities = 75/352 (21%), Positives = 112/352 (31%), Gaps = 43/352 (12%)

Query: 1842 PASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEP---STPTVLRSTSTSSPV 1898
            PA         P+ P T    + RP +  +   +       P   S PT   ST+T  P 
Sbjct: 448  PAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPP 507

Query: 1899 RPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARS 1958
              + T  P +   L      + P +             AR  R         + K P R 
Sbjct: 508  EDSPTVAPKSTTFLKNIRQFIMPVVS------------ARSSR---------VIKTPRRF 546

Query: 1959 GLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQ 2018
              E    P K      L PP++    + + PA   +P  A   PP+ P    +  R   +
Sbjct: 547  MDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPT-PPSTPVPLPEKRRSILR 605

Query: 2019 SKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELR 2078
               F    L  R L       +P      SP  +P+ +  + L     +   S    ++ 
Sbjct: 606  EPTFRWTSL-TREL--PPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIY 662

Query: 2079 PKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDY 2138
                 P  LG   A  P   P  +S     P    A G   H  +   A  ++  +  + 
Sbjct: 663  ESVLTPPPLGAPEAPEPEPPPADDSPAEPEP---RAVGRTNHLSLPRFAPVVTTPVKAEV 719

Query: 2139 TRHHPQQLS------APLPAPLYSFPGASCPVL------DLRRPPSDLYLPP 2178
            + H    LS      A L  PL +      P         L+ PPS   +PP
Sbjct: 720  SPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPP 771



 Score = 37.0 bits (84), Expect = 0.24
 Identities = 85/401 (21%), Positives = 127/401 (31%), Gaps = 82/401 (20%)

Query: 1735 VPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRE 1794
            +PP P TP       A  P  P P  S     PL P  P  ++ P   S        ++E
Sbjct: 401  LPPPPLTPP------APSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQE 454

Query: 1795 RDR--------DREREKSILTSTTTVEH--APIWRPGTEQSSGSSGSSGGGGGSSSRPAS 1844
                        R+R +  LT +   E   A     GT   + +  ++ GG    S   +
Sbjct: 455  ESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVA 514

Query: 1845 HSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTV-----LRSTSTSSPV- 1898
                     I       +  R S +  T  +  +    P  P V     LR   T+SP  
Sbjct: 515  PKSTTFLKNIRQFIMPVVSARSSRVIKTPRR-FMDEDPPKPPKVEVSPVLRPPITTSPPV 573

Query: 1899 ---------RPAATFPPATHCPLGGTLDGVY--PT---------LMEPVLLPKEAPRVAR 1938
                      P A  PP+T  PL      +   PT         L  P   P   P  + 
Sbjct: 574  PQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSP 633

Query: 1939 PERPRADTGHAFLAKPP----------------------ARSGLEPASSPSKGS--EPRP 1974
            P  P   +    L + P                      A    EP   P+  S  EP P
Sbjct: 634  PPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEP 693

Query: 1975 LVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGY 2034
                 + H ++ R       P  A   P   PA ++ P  +    +P  +Q L+ + L  
Sbjct: 694  RAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQP--LQALQTQLL-- 749

Query: 2035 HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEG 2075
                  P+ + P  P   P  +     P+ +  L+K+ + G
Sbjct: 750  ------PQALPPPQPQLQPPPS-----PQQMPPLEKARIAG 779



 Score = 33.9 bits (76), Expect = 2.0
 Identities = 13/34 (38%), Positives = 25/34 (73%)

Query: 506 QQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVE 539
           ++Q+Q +    +E+K+E+EK+KE E++EE+   E
Sbjct: 355 KKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAE 388



 Score = 32.7 bits (73), Expect = 4.5
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%)

Query: 488 RRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEK--EKEKEAEKEEEKPEVENDKEDL 545
           RR G  Q      ++Q+Q+   +   +  +EEKD++  EKE+ A  EE  P  E ++  L
Sbjct: 342 RRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKL 401



 Score = 32.3 bits (72), Expect = 5.9
 Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 10/115 (8%)

Query: 105 SKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPH-TDPELELV 163
           +++   +L P PL  P+P      P  S         T    P+ PP PP  + P L   
Sbjct: 394 AEKEEAKLPPPPLTPPAPSPPPPLPPPS---------TSPPPPLCPPPPPPVSPPPLPSP 444

Query: 164 PPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPP 218
           PP  ++EE  ++   V       ++    L   Q+   E A   PE   P +P P
Sbjct: 445 PPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTP 499


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 134/528 (25%), Positives = 169/528 (32%), Gaps = 129/528 (24%)

Query: 762  PPGPPTPPPEDIPAPTE---------PTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEE 812
            PPG P PPP   PA              P +E  G       P S     P         
Sbjct: 29   PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 813  ETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTE------------EAEEGPAKG 860
              A+ PP     E+ PPA        G    P ++  T              AEE  A+G
Sbjct: 89   NPASRPPASGRGERAPPAKN---TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 145

Query: 861  KDAEAAEATAEGA---------------------LKAEKKEGGSGRATTAKSSGAPQDSD 899
            K  EA + +A  A                      +A   E G  R   +     P +  
Sbjct: 146  KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 205

Query: 900  SSATCSADEVDEAE-----------GGDKNR------------LLSPRPSLLTPTGDPRA 936
              +  SA E    E           GG   R            L SP  S  +  G PRA
Sbjct: 206  RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 937  NASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP----------TKPAPPA----- 981
             A P +P       +   A+ P QVT    PPR+DAAP            P+P A     
Sbjct: 266  PAHPSQP-----KPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSAALQSQ 316

Query: 982  PPPPQNLQPESD------------APQQPGSSPRGKSRSPAPPA--DKEAEKPVFFPAFA 1027
             PP     P S             AP  P S+P      P+PPA    +A   +  P   
Sbjct: 317  APPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQATTSLGSPTLQ 375

Query: 1028 AEAQKLPGDPPCWTSGLPFP-------VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLH 1080
            A    LP  PP      P P       +PP +   + P +P  S  +   P  P  L +H
Sbjct: 376  ATHSFLP-SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 434

Query: 1081 DTARPVLPRP-PTISNP------PPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAK 1133
                P  P P P +  P      PP+  SA  PS     + A        L VP S  A 
Sbjct: 435  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA------PPLQVPPSPPAS 488

Query: 1134 APVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPP-ESLGVPTA 1180
             P+ P     P    P    P    K    +P   A PP ++L  P A
Sbjct: 489  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA 536



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 129/543 (23%), Positives = 168/543 (30%), Gaps = 76/543 (13%)

Query: 683  KKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAA 742
            K  +P   S             +   G+  + EE V   +AT        S  +    + 
Sbjct: 107  KNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSG 166

Query: 743  KDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP 802
               G   P       A G   G P P P   P P    P    + A       PSP+   
Sbjct: 167  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPA--- 223

Query: 803  PVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGP-AKG- 860
                        A   P   G  Q+ PA+  L+        P +S        GP A+G 
Sbjct: 224  ------------ARRRPSAGGGLQR-PASRSLSSSATPLSSPARS--------GPSARGT 262

Query: 861  --KDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 918
                A  ++   +G       +    R   A + G P  S   AT S     +++     
Sbjct: 263  PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAALQSQ-APPT 320

Query: 919  RLLSPRPSLLT---PTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEP-------- 967
               +P  S LT    T  P A  SP  P  L+ L    A  P    T +  P        
Sbjct: 321  LPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSF 380

Query: 968  -PREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAF 1026
             P    +P    PP  PP   L P    P  P S P     +P+P A           A 
Sbjct: 381  LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN---------AL 431

Query: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPV 1086
            A    + P  PP        P PP +    SP A  P + S  PP    P      A P 
Sbjct: 432  AVHLLQAPFSPP--------PSPPVQA-PFSPPASPPVSPSATPPSQAPP----SLAAPP 478

Query: 1087 LPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLP 1146
            L  PP+    PP+  SA  P      + A      +QL  P  +   A   P    LP P
Sbjct: 479  LQVPPSPPASPPMSPSATPPPQAPPPLAA----PPLQLAKPPPQAPPALATPPLQALPSP 534

Query: 1147 MDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPST 1206
                   P S   Q   SP     P   L  P  Q   VL    L   P    +  + + 
Sbjct: 535  -------PASFPGQAPFSPSASL-PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586

Query: 1207 RVP 1209
            R P
Sbjct: 587  RRP 589



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 103/443 (23%), Positives = 156/443 (35%), Gaps = 59/443 (13%)

Query: 681  RKKKKAPAAASE------EAAFPPVVEDEEMEASGVSG--NEEEMVEEAEATVNNSSDTE 732
            R   +APA  S+      +A  PP V     +A+   G  +   +   + +    S    
Sbjct: 260  RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP 319

Query: 733  SIPSPHTEAAKDTGQNGPKPPATLGADGPP-----PGPP-TPPPEDIPAPTEPTPASEAT 786
            ++P+    ++       P P A      PP     P PP TPP +   +   PT  +  +
Sbjct: 320  TLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHS 379

Query: 787  GAPTPPPAP---PSPSAPPPV-VPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKA- 841
              P+PP +P   P P APP + +P  +      A+PP+       P A   LAV   +A 
Sbjct: 380  FLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP 439

Query: 842  -----EEPVKSECTEEAEE--GPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA 894
                   PV++  +  A     P+    ++A  + A   L+       S  A+   S  A
Sbjct: 440  FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP----SPPASPPMSPSA 495

Query: 895  PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP-----RANASPQKPLDLKQL 949
                 +    +A  +  A+   +       P L      P     +A  SP   L +  L
Sbjct: 496  TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 555

Query: 950  KQRAAAIPPIQVTKVHE-PPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR---GK 1005
                   PP+    + + PP   A+PT  AP  PP P         P    S PR     
Sbjct: 556  ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP--------GPDTSVSGPRLTLAL 607

Query: 1006 SRSPAPPADKEAEKPVFFPAFA---AEAQKLPGDPPCWTSG-----LPFPVPPREVIKAS 1057
            +  P PP  +     +  P  A   + A   P +   + SG        P P  E+    
Sbjct: 608  APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH 667

Query: 1058 PHA----PDPSAFSYAPPGHPLP 1076
            P A    P P       PG PLP
Sbjct: 668  PAAWSRGPAPPLAFRGAPGAPLP 690



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 136/579 (23%), Positives = 190/579 (32%), Gaps = 131/579 (22%)

Query: 1737 PTPGTPATAMDRLAYLPTA----PQPFSSRHSSSPLSPGGP----THLTKPTTTSSSERE 1788
            PTPGTP+ AM R +         P+P  S     P    GP    +  ++ +TT  S   
Sbjct: 167  PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE--GPRKSVSSASEHSTTEPSPAA 224

Query: 1789 RDRDR-----ERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA 1843
            R R       +R   R    S    ++     P  R GT ++          G  + RP 
Sbjct: 225  RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPP 283

Query: 1844 SHSHAHQHS-----PIS------PRTQDALQ-QRPSVLHNTGMKGIITAVEPSTPTVLRS 1891
              +   + +     P+S      P    ALQ Q P  L  T     +T  + +TP  L  
Sbjct: 284  QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC-QLATPLPLAP 342

Query: 1892 TSTSSPVR------PAATFPPATHCPLGG-TLDGVYPTLMEPVLLPKEAPRVARPERPRA 1944
             S S+P        P AT P      LG  TL   +  L  P L P   P    P+ P A
Sbjct: 343  PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP---PQAPPA 399

Query: 1945 DTGHAFLA--KPPARSGLEPASSPSKGSE--------------------PRPLVPPVSGH 1982
                   A   PPA   L P ++PS  +                       P  PP S  
Sbjct: 400  LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 459

Query: 1983 ATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFS------------------- 2023
             + + TP     P  A+P    PP+  + P    + + P                     
Sbjct: 460  VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519

Query: 2024 --------IQELELRSLGYHGSS-YSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKS--- 2071
                    +Q L      + G + +SP    P+SP+++P       L   L ++  S   
Sbjct: 520  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 579

Query: 2072 --HLEGELRPKQPGP-VKLGGEAAHLPHLRPLPESQPSSSP-LLQTAPGVKGHQRVVTLA 2127
               L+   RP  PGP   + G    L  L P P   PS SP    + P + GH    T  
Sbjct: 580  SPTLQAPRRPPTPGPDTSVSGPRLTLA-LAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 638

Query: 2128 QH--------------ISEVITQDYTRHHPQQLS--------------APLPAPLYSFPG 2159
                             S     +    HP   S              APLP P  + PG
Sbjct: 639  PEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698

Query: 2160 AS---CPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGK 2195
            ++   C + +   P S    P      P   SP + GGK
Sbjct: 699  SADGLCTIYETEGPESATPAPGALDPGP---SPGTSGGK 734



 Score = 35.0 bits (79), Expect = 0.91
 Identities = 76/317 (23%), Positives = 99/317 (31%), Gaps = 80/317 (25%)

Query: 2158 PGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVS 2217
            P A  P L   RPP     PPP   A  R    +    R P   +   +GG        +
Sbjct: 17   PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG-------AT 69

Query: 2218 PPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSK 2277
             PE     G +RSA                 G+ S    S+PPA  S   E       + 
Sbjct: 70   IPESAPRAGPTRSA-----------------GTSSRNPASRPPA--SGRGERAPPAKNTS 110

Query: 2278 KQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAII 2337
               ++          P   + Q G  I                 + +E  +     EA  
Sbjct: 111  PGPVSSPGRASGTTRPG-PLGQKGLRI-----------------SAEETVARGKATEAPK 152

Query: 2338 RKALMGGGGK---AKVSGRPSSRKAKS----------PAPGLASGDRPP------SVSSV 2378
            R AL  G  +       G PS   A+           P P  ++  RPP      SVSS 
Sbjct: 153  RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 212

Query: 2379 HSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLA- 2437
             SE      +P   R    RPS+ G    P           + +S  P   PA SGP A 
Sbjct: 213  -SEHSTTEPSPAARR----RPSAGGGLQRP-------ASRSLSSSATPLSSPARSGPSAR 260

Query: 2438 ----GPHHAWDEEPKPL 2450
                 P H    +PK L
Sbjct: 261  GTPRAPAHPSQPKPKGL 277



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 61/275 (22%), Positives = 89/275 (32%), Gaps = 36/275 (13%)

Query: 1929 LPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIART 1988
            +P+ APR A P R    +     ++PPA SG    + P+K + P P+  P     T    
Sbjct: 70   IPESAPR-AGPTRSAGTSSRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPG 127

Query: 1989 PAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVS 2048
            P        ++ +  A   +   P R    +                G+     G  P +
Sbjct: 128  PLGQKGLRISAEETVARGKATEAPKRSALSA----------------GARRDTSGPTPGT 171

Query: 2049 PVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPES--QPS 2106
            P  SP++            L +       RP   GP K    A+      P P +  +PS
Sbjct: 172  P--SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPS 229

Query: 2107 SSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLD 2166
            +   LQ             L+       +   T   P   S P P  L +          
Sbjct: 230  AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL--------- 280

Query: 2167 LRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPN 2201
              RPP     PP    APA G P S     +P P+
Sbjct: 281  --RPPQ--VTPPRKDAAPALG-PLSSSPLATPSPS 310


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 127,399,661
Number of Sequences: 37866
Number of extensions: 8468199
Number of successful extensions: 165420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1384
Number of HSP's successfully gapped in prelim test: 2865
Number of HSP's that attempted gapping in prelim test: 47685
Number of HSP's gapped (non-prelim): 62207
length of query: 2462
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2343
effective length of database: 13,741,464
effective search space: 32196250152
effective search space used: 32196250152
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.