Search of human proteins with 237512982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|237512982 voltage-gated sodium channel type V alpha isoform
f [Homo sapiens]
         (1962 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|237512982 voltage-gated sodium channel type V alpha isoform f...  3936   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  3902   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  3898   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  3889   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  3854   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  3830   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  2447   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  2435   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  2435   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  2435   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  2407   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  2400   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  2399   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  2366   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2355   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2352   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1748   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1462   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1369   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1139   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   448   e-125
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   444   e-124
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   436   e-121
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   436   e-121
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   436   e-121
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...   436   e-121
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...   435   e-121
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...   430   e-120
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...   430   e-120
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...   430   e-120

>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 3936 bits (10207), Expect = 0.0
 Identities = 1962/1962 (100%), Positives = 1962/1962 (100%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPED 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPED
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPED 1080

Query: 1081 SCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRL 1140
            SCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRL
Sbjct: 1081 SCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRL 1140

Query: 1141 RKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEM 1200
            RKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEM
Sbjct: 1141 RKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEM 1200

Query: 1201 LLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRAL 1260
            LLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRAL
Sbjct: 1201 LLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRAL 1260

Query: 1261 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1320
            SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN
Sbjct: 1261 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1320

Query: 1321 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1380
            YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY
Sbjct: 1321 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1380

Query: 1381 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1440
            EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY
Sbjct: 1381 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1440

Query: 1441 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1500
            YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP
Sbjct: 1441 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1500

Query: 1501 EKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQK 1560
            EKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQK
Sbjct: 1501 EKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQK 1560

Query: 1561 YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIF 1620
            YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIF
Sbjct: 1561 YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIF 1620

Query: 1621 GMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPN 1680
            GMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPN
Sbjct: 1621 GMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPN 1680

Query: 1681 SNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMF 1740
            SNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMF
Sbjct: 1681 SNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMF 1740

Query: 1741 YEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDIL 1800
            YEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDIL
Sbjct: 1741 YEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDIL 1800

Query: 1801 FAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRR 1860
            FAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRR
Sbjct: 1801 FAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRR 1860

Query: 1861 HLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFP 1920
            HLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFP
Sbjct: 1861 HLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFP 1920

Query: 1921 PSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            PSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1921 PSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 3902 bits (10120), Expect = 0.0
 Identities = 1960/2016 (97%), Positives = 1960/2016 (97%), Gaps = 54/2016 (2%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1077 -------TPED-------------------------------------------SCSEGS 1086
                    P D                                           SCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1087 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1147 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1206
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1207 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1266
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1267 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1326
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1327 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1386
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440

Query: 1387 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500

Query: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560

Query: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620

Query: 1567 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680

Query: 1627 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1686
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740

Query: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800

Query: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860

Query: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920

Query: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980

Query: 1927 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 3898 bits (10109), Expect = 0.0
 Identities = 1955/2015 (97%), Positives = 1958/2015 (97%), Gaps = 53/2015 (2%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQP 1080

Query: 1077 -------------------------------------------------TPEDSCSEGST 1087
                                                             TPEDSCSEGST
Sbjct: 1081 VSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGST 1140

Query: 1088 ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI 1147
            ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI 1200

Query: 1148 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1207
            VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY
Sbjct: 1201 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1260

Query: 1208 GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 1267
            GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR
Sbjct: 1261 GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 1320

Query: 1268 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 1327
            VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK
Sbjct: 1321 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 1380

Query: 1328 SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1387
            SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE
Sbjct: 1381 SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1440

Query: 1388 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447
            YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL
Sbjct: 1441 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1500

Query: 1448 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1507
            GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA
Sbjct: 1501 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1560

Query: 1508 KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL 1567
            KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL
Sbjct: 1561 KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL 1620

Query: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627
            FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY
Sbjct: 1621 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1680

Query: 1628 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD 1687
            VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD
Sbjct: 1681 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD 1740

Query: 1688 CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF 1747
            CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF
Sbjct: 1741 CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF 1800

Query: 1748 DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV 1807
            DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV
Sbjct: 1801 DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV 1860

Query: 1808 LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL 1867
            LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL
Sbjct: 1861 LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL 1920

Query: 1868 KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT 1927
            KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT
Sbjct: 1921 KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT 1980

Query: 1928 RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2015


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 3889 bits (10086), Expect = 0.0
 Identities = 1953/2016 (96%), Positives = 1956/2016 (97%), Gaps = 54/2016 (2%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1077 -------TPED-------------------------------------------SCSEGS 1086
                    P D                                           SCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1087 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1147 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1206
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1207 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1266
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1267 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1326
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1327 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1386
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440

Query: 1387 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500

Query: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560

Query: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620

Query: 1567 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680

Query: 1627 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1686
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740

Query: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800

Query: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860

Query: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920

Query: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980

Query: 1927 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 3854 bits (9994), Expect = 0.0
 Identities = 1942/2016 (96%), Positives = 1942/2016 (96%), Gaps = 72/2016 (3%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1077 -------TPED-------------------------------------------SCSEGS 1086
                    P D                                           SCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1087 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1147 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1206
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1207 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1266
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1267 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1326
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1327 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1386
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV                  YEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV------------------YEEQPQW 1422

Query: 1387 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1423 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1482

Query: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1483 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1542

Query: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1543 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1602

Query: 1567 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1603 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662

Query: 1627 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1686
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1663 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1722

Query: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1723 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1782

Query: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1783 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1842

Query: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1843 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1902

Query: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1903 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1962

Query: 1927 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1963 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1998


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 3830 bits (9932), Expect = 0.0
 Identities = 1930/2015 (95%), Positives = 1930/2015 (95%), Gaps = 85/2015 (4%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQP 1080

Query: 1077 -------------------------------------------------TPEDSCSEGST 1087
                                                             TPEDSCSEGST
Sbjct: 1081 VSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGST 1140

Query: 1088 ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI 1147
            ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI 1200

Query: 1148 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1207
            VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY
Sbjct: 1201 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1260

Query: 1208 GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 1267
            GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR
Sbjct: 1261 GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 1320

Query: 1268 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 1327
            VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK
Sbjct: 1321 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 1380

Query: 1328 SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1387
            SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE
Sbjct: 1381 SQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1440

Query: 1388 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447
            YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL
Sbjct: 1441 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1500

Query: 1448 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1507
            GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA
Sbjct: 1501 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1560

Query: 1508 KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL 1567
            KINLLFVAIFT                                GTVLSDIIQKYFFSPTL
Sbjct: 1561 KINLLFVAIFT--------------------------------GTVLSDIIQKYFFSPTL 1588

Query: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627
            FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY
Sbjct: 1589 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1648

Query: 1628 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD 1687
            VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD
Sbjct: 1649 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD 1708

Query: 1688 CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF 1747
            CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF
Sbjct: 1709 CGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKF 1768

Query: 1748 DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV 1807
            DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV
Sbjct: 1769 DPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRV 1828

Query: 1808 LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL 1867
            LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL
Sbjct: 1829 LGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSL 1888

Query: 1868 KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT 1927
            KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT
Sbjct: 1889 KHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVT 1948

Query: 1928 RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962
            RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1949 RATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1983


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 2447 bits (6342), Expect = 0.0
 Identities = 1289/2011 (64%), Positives = 1521/2011 (75%), Gaps = 114/2011 (5%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVP--WPLRRTSAQGQPSPGT-SAPGHALHGKKNSTVDCNGVVSLLG 605
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658

Query: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
             G    TSP   L        PP+ TT +E     + L+S    ++  E+   RQRA+S 
Sbjct: 659  -GPSALTSPTGQL--------PPEGTT-TETEVRKRRLSSYQISMEMLEDSSGRQRAVSI 708

Query: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768

Query: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828

Query: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888

Query: 846  LAIIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948

Query: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008

Query: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKEL 1061

Query: 1024 KETRFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEEN 1065
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121

Query: 1066 SLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCC 1125
            S    EES ++    S SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C
Sbjct: 1122 SESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFC 1180

Query: 1126 AVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLL 1185
             V T +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +L
Sbjct: 1181 QVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1240

Query: 1186 EYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPI 1245
            EYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G I
Sbjct: 1241 EYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAI 1300

Query: 1246 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1305
            KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1301 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1360

Query: 1306 FGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFK 1365
            F  C+N T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFK
Sbjct: 1361 FYHCVNMTTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFK 1417

Query: 1366 GWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1425
            GWMDIMYAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1418 GWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1477

Query: 1426 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLIC 1485
             GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LIC
Sbjct: 1478 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1537

Query: 1486 LNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVV 1545
            LNMVTMMVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVV
Sbjct: 1538 LNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVV 1597

Query: 1546 ILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFN 1605
            ILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFN
Sbjct: 1598 ILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1657

Query: 1606 IGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1665
            IGLLLFLVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+P
Sbjct: 1658 IGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1717

Query: 1666 ILNTGPPYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVA 1724
            ILN+ PP CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVA
Sbjct: 1718 ILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1777

Query: 1725 TEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINM 1784
            TEES EPLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI M
Sbjct: 1778 TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAM 1837

Query: 1785 DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRR 1844
            DLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+R
Sbjct: 1838 DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKR 1897

Query: 1845 KHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSR 1904
            K EEVSA +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N + 
Sbjct: 1898 KQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST- 1954

Query: 1905 PLGPPSSSSISSTSFPPSYDSVTRATSDNLQ 1935
               P  +   SST+ PPSYDSVT+   +  +
Sbjct: 1955 ---PEKTDGSSSTTSPPSYDSVTKPDKEKFE 1982


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 2435 bits (6311), Expect = 0.0
 Identities = 1290/2027 (63%), Positives = 1526/2027 (75%), Gaps = 122/2027 (6%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
            +E +S    EES ++    S SEGST D+   AE  EQ     ++  +PE CFTE CVR+
Sbjct: 1120 EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDCVRK 1178

Query: 1122 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1181
              CC +   +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTI
Sbjct: 1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTI 1238

Query: 1182 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1241
            K +LEYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E
Sbjct: 1239 KTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSE 1298

Query: 1242 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1301
            +G IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1299 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1358

Query: 1302 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQ 1360
            FAGKF  CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQ
Sbjct: 1359 FAGKFYHCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQ 1417

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            VATFKGWMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1418 VATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1477

Query: 1421 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1480
            QQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++I
Sbjct: 1478 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISI 1537

Query: 1481 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1540
            M LICLNMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIF
Sbjct: 1538 MILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIF 1597

Query: 1541 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1600
            DFVVVILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSL
Sbjct: 1598 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1657

Query: 1601 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1660
            PALFNIGLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWD
Sbjct: 1658 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWD 1717

Query: 1661 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1719
            GLL+PILN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILE
Sbjct: 1718 GLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777

Query: 1720 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1779
            NFSVATEES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++
Sbjct: 1778 NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKV 1837

Query: 1780 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1839
             LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPIT
Sbjct: 1838 QLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPIT 1897

Query: 1840 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS 1899
            TTL+RK EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++
Sbjct: 1898 TTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLN 1955

Query: 1900 ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1946
            EN +    P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1956 ENST----PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2435 bits (6310), Expect = 0.0
 Identities = 1290/2027 (63%), Positives = 1526/2027 (75%), Gaps = 122/2027 (6%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
            +E +S    EES ++    S SEGST D+   AE  EQ     ++  +PE CFTE CVR+
Sbjct: 1120 EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDCVRK 1178

Query: 1122 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1181
              CC +   +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTI
Sbjct: 1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTI 1238

Query: 1182 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1241
            K +LEYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E
Sbjct: 1239 KTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSE 1298

Query: 1242 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1301
            +G IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1299 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1358

Query: 1302 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQ 1360
            FAGKF  CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQ
Sbjct: 1359 FAGKFYHCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQ 1417

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            VATFKGWMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1418 VATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1477

Query: 1421 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1480
            QQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++I
Sbjct: 1478 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISI 1537

Query: 1481 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1540
            M LICLNMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIF
Sbjct: 1538 MILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIF 1597

Query: 1541 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1600
            DFVVVILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSL
Sbjct: 1598 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1657

Query: 1601 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1660
            PALFNIGLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWD
Sbjct: 1658 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWD 1717

Query: 1661 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1719
            GLL+PILN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILE
Sbjct: 1718 GLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777

Query: 1720 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1779
            NFSVATEES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++
Sbjct: 1778 NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKV 1837

Query: 1780 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1839
             LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPIT
Sbjct: 1838 QLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPIT 1897

Query: 1840 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS 1899
            TTL+RK EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++
Sbjct: 1898 TTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLN 1955

Query: 1900 ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1946
            EN +    P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1956 ENST----PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2435 bits (6310), Expect = 0.0
 Identities = 1290/2027 (63%), Positives = 1526/2027 (75%), Gaps = 122/2027 (6%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
            +E +S    EES ++    S SEGST D+   AE  EQ     ++  +PE CFTE CVR+
Sbjct: 1120 EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDCVRK 1178

Query: 1122 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1181
              CC +   +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTI
Sbjct: 1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTI 1238

Query: 1182 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1241
            K +LEYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E
Sbjct: 1239 KTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSE 1298

Query: 1242 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1301
            +G IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1299 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1358

Query: 1302 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQ 1360
            FAGKF  CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQ
Sbjct: 1359 FAGKFYHCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQ 1417

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            VATFKGWMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1418 VATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1477

Query: 1421 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1480
            QQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++I
Sbjct: 1478 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISI 1537

Query: 1481 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1540
            M LICLNMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIF
Sbjct: 1538 MILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIF 1597

Query: 1541 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1600
            DFVVVILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSL
Sbjct: 1598 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1657

Query: 1601 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1660
            PALFNIGLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWD
Sbjct: 1658 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWD 1717

Query: 1661 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1719
            GLL+PILN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILE
Sbjct: 1718 GLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777

Query: 1720 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1779
            NFSVATEES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++
Sbjct: 1778 NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKV 1837

Query: 1780 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1839
             LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPIT
Sbjct: 1838 QLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPIT 1897

Query: 1840 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS 1899
            TTL+RK EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++
Sbjct: 1898 TTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLN 1955

Query: 1900 ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1946
            EN +    P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1956 ENST----PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 2407 bits (6239), Expect = 0.0
 Identities = 1274/2015 (63%), Positives = 1500/2015 (74%), Gaps = 107/2015 (5%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301

Query: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478

Query: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538

Query: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598

Query: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888

Query: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065

Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDD-QEEDEENSL 1067
            +   G   G GT    E                   V VPIAV ESD ++   ED  +  
Sbjct: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSES 1125

Query: 1068 GTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1127
              EE   K     S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC +
Sbjct: 1126 DLEESKEKLNESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQI 1183

Query: 1128 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1187
            +  +  GK WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEY
Sbjct: 1184 NVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEY 1243

Query: 1188 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1247
            ADK+FTY+F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1244 ADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1303

Query: 1248 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1307
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1304 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1363

Query: 1308 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1366
             CIN T GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1364 HCINTTTGDR-FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKG 1422

Query: 1367 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1426
            WMDIMYAAVDSR  E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1423 WMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1482

Query: 1427 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1486
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICL
Sbjct: 1483 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICL 1542

Query: 1487 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1546
            NMVTMMVETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI
Sbjct: 1543 NMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVI 1602

Query: 1547 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1606
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1603 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1662

Query: 1607 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1666
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1663 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1722

Query: 1667 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1725
            LN+ PP CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1723 LNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1782

Query: 1726 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1785
            EES EPLSEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MD
Sbjct: 1783 EESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMD 1842

Query: 1786 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1845
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK
Sbjct: 1843 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRK 1902

Query: 1846 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1905
             EEVSA++IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    
Sbjct: 1903 QEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---S 1957

Query: 1906 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSD 1940
            +   +  ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1958 ITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKD 1992


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 2400 bits (6219), Expect = 0.0
 Identities = 1266/2008 (63%), Positives = 1497/2008 (74%), Gaps = 157/2008 (7%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842

Query: 849  IVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKELNYL 1015

Query: 1027 RFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEENSLG 1068
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075

Query: 1069 TEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1128
              EES ++    S SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C V 
Sbjct: 1076 ELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVS 1134

Query: 1129 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1188
            T +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1135 TEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1194

Query: 1189 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1248
            DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSL
Sbjct: 1195 DKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSL 1254

Query: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308
            RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  
Sbjct: 1255 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1314

Query: 1309 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1368
            C+N T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFKGWM
Sbjct: 1315 CVNMTTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFKGWM 1371

Query: 1369 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1428
            DIMYAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GG
Sbjct: 1372 DIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG 1431

Query: 1429 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNM 1488
            QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNM
Sbjct: 1432 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM 1491

Query: 1489 VTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILS 1548
            VTMMVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILS
Sbjct: 1492 VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILS 1551

Query: 1549 IVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGL 1608
            IVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGL
Sbjct: 1552 IVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611

Query: 1609 LLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILN 1668
            LLFLVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN
Sbjct: 1612 LLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671

Query: 1669 TGPPYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEE 1727
            + PP CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEE
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731

Query: 1728 STEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLP 1787
            S EPLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLP
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLP 1791

Query: 1788 MVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHE 1847
            MVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK E
Sbjct: 1792 MVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQE 1851

Query: 1848 EVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLG 1907
            EVSA +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    
Sbjct: 1852 EVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST---- 1905

Query: 1908 PPSSSSISSTSFPPSYDSVTRATSDNLQ 1935
            P  +   SST+ PPSYDSVT+   +  +
Sbjct: 1906 PEKTDGSSSTTSPPSYDSVTKPDKEKFE 1933


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 2399 bits (6218), Expect = 0.0
 Identities = 1266/2008 (63%), Positives = 1497/2008 (74%), Gaps = 157/2008 (7%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842

Query: 849  IVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKELNYL 1015

Query: 1027 RFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEENSLG 1068
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075

Query: 1069 TEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1128
              EES ++    S SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C V 
Sbjct: 1076 ELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVS 1134

Query: 1129 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1188
            T +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1135 TEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1194

Query: 1189 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1248
            DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSL
Sbjct: 1195 DKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSL 1254

Query: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308
            RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  
Sbjct: 1255 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1314

Query: 1309 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1368
            C+N T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFKGWM
Sbjct: 1315 CVNMTTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFKGWM 1371

Query: 1369 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1428
            DIMYAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GG
Sbjct: 1372 DIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG 1431

Query: 1429 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNM 1488
            QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNM
Sbjct: 1432 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM 1491

Query: 1489 VTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILS 1548
            VTMMVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILS
Sbjct: 1492 VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILS 1551

Query: 1549 IVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGL 1608
            IVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGL
Sbjct: 1552 IVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611

Query: 1609 LLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILN 1668
            LLFLVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN
Sbjct: 1612 LLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671

Query: 1669 TGPPYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEE 1727
            + PP CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEE
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731

Query: 1728 STEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLP 1787
            S EPLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLP
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLP 1791

Query: 1788 MVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHE 1847
            MVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK E
Sbjct: 1792 MVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQE 1851

Query: 1848 EVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLG 1907
            EVSA +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    
Sbjct: 1852 EVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST---- 1905

Query: 1908 PPSSSSISSTSFPPSYDSVTRATSDNLQ 1935
            P  +   SST+ PPSYDSVT+   +  +
Sbjct: 1906 PEKTDGSSSTTSPPSYDSVTKPDKEKFE 1933


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 2366 bits (6132), Expect = 0.0
 Identities = 1242/2000 (62%), Positives = 1508/2000 (75%), Gaps = 94/2000 (4%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179

Query: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
             FTFLRDPWNWLDF VI+ AY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293

Query: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353

Query: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413

Query: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473

Query: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533

Query: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593

Query: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645

Query: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702

Query: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762

Query: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822

Query: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882

Query: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942

Query: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002

Query: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062

Query: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTAD-- 1089
              GQ    +P   V VPIA  ESD ++   +E +S    E S  +    S SE ST D  
Sbjct: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNP 1122

Query: 1090 MTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVE 1149
            +    E  E  P    +  +PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVE
Sbjct: 1123 LPGEGEEAEAEP---MNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVE 1179

Query: 1150 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF 1209
            HSWFE+FI+ MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+
Sbjct: 1180 HSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGY 1239

Query: 1210 KKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVV 1269
            K YFTNAWCWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVV
Sbjct: 1240 KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVV 1299

Query: 1270 VNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKS 1328
            VNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S
Sbjct: 1300 VNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRS 1357

Query: 1329 QCESL-NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1387
            +C +L N++  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++E
Sbjct: 1358 ECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYE 1417

Query: 1388 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447
            Y+LYMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL
Sbjct: 1418 YSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477

Query: 1448 GSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILA 1507
            GSKKPQKPIPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L 
Sbjct: 1478 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLY 1537

Query: 1508 KINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL 1567
             IN++F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTL
Sbjct: 1538 WINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTL 1597

Query: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627
            FRVIRLARIGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAY
Sbjct: 1598 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1657

Query: 1628 VKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RG 1686
            VK E GI+DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  G
Sbjct: 1658 VKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEG 1717

Query: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746
            DCG+P+VGI +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEK
Sbjct: 1718 DCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777

Query: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806
            FDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKR
Sbjct: 1778 FDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKR 1837

Query: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866
            VLGESGEMD+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L+++
Sbjct: 1838 VLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQN 1897

Query: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926
            +K+ S ++ +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSV
Sbjct: 1898 VKNISSIYIK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSV 1950

Query: 1927 TRATSDNLQVRGSDYSHSED 1946
            T+   +  +    D +  ED
Sbjct: 1951 TKPDKEKYE---QDRTEKED 1967


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2355 bits (6104), Expect = 0.0
 Identities = 1252/2015 (62%), Positives = 1471/2015 (73%), Gaps = 154/2015 (7%)

Query: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68

Query: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128

Query: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185

Query: 190  RDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 249
            RDPWNWLDFSVI +AYV   I L  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245

Query: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291

Query: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351

Query: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411

Query: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471

Query: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556

Query: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613

Query: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673

Query: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733

Query: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793

Query: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853

Query: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913

Query: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965

Query: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEED------- 1062
            T +      G   G   P  P              V VPIA  ESD DD E+D       
Sbjct: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQS 1019

Query: 1063 ------------------------EENSLGT---------------EEESSKQTPED--- 1080
                                       S GT               ++ES  Q P +   
Sbjct: 1020 FQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVD 1079

Query: 1081 --SCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1138
              S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++P  V W
Sbjct: 1080 DTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW 1139

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1198
            ++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++FT++FV 
Sbjct: 1140 QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVF 1199

Query: 1199 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1258
            EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLRALRPLR
Sbjct: 1200 EMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLR 1259

Query: 1259 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1318
            ALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN T+G+  
Sbjct: 1260 ALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFS 1319

Query: 1319 L-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1377
            L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIMYAAVDS
Sbjct: 1320 LVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDS 1379

Query: 1378 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQ 1437
            R    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDIFMTEEQ
Sbjct: 1380 REVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQ 1439

Query: 1438 KKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDD 1497
            KKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TMMVETDD
Sbjct: 1440 KKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDD 1499

Query: 1498 QSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDI 1557
            QS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI   + S I
Sbjct: 1500 QSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAI 1559

Query: 1558 IQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1615
            ++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1560 LKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1619

Query: 1616 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1675
            IYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD
Sbjct: 1620 IYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1679

Query: 1676 PTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1735
            P LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEESTEPLSED
Sbjct: 1680 PNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSED 1739

Query: 1736 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIH 1795
            DFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V GD+IH
Sbjct: 1740 DFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIH 1799

Query: 1796 CMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1855
            C+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++SA VIQ
Sbjct: 1800 CLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQ 1859

Query: 1856 RAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLGPPSSSS 1913
            +A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + P  S +
Sbjct: 1860 KAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VLPDKSET 1911

Query: 1914 ISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 1948
             S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1912 ASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2352 bits (6094), Expect = 0.0
 Identities = 1268/2008 (63%), Positives = 1492/2008 (74%), Gaps = 125/2008 (6%)

Query: 2    ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
            A  L P G  SF+ FT ESLA IE+R+AE + +       S     E+  P+P  DL+A 
Sbjct: 3    ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62

Query: 62   KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
            K LP +YG+ PQ L+  PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 63   KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122

Query: 122  RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
            R A+KIL+HS+F+M+IMCTILTNCVFM   +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 123  RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182

Query: 182  CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
            C+  FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 183  CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242

Query: 242  ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
            ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV    NF      NG+    G
Sbjct: 243  ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299

Query: 299  LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
              WE    Y+++  N+    G  + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 300  FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356

Query: 359  AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
            +WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 357  SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416

Query: 419  QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
            QNQAT+ E E+KE  F+  +E LKK+ E    A       TVS               RS
Sbjct: 417  QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476

Query: 460  SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
            S E+S L+  ++ ERR++R+KR    +S G E+   +++ KS+SEDG R           
Sbjct: 477  SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536

Query: 505  ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
                ++ + SL        +   +S+ SIF+FR     RD GSE +FADDE+ST  ESE 
Sbjct: 537  GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596

Query: 557  HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
               SL +P   R  R+S  G    S G+ +    P      K+NSTVDCNGVVSL+G   
Sbjct: 597  RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                 PGSH+   ++ E   +     + PG   +L S    +D     G + R  S +SV
Sbjct: 655  -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703

Query: 669  LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
            +T+ L EELEES+ KCPPCW + A  +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 704  VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763

Query: 728  VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
            VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM  K+IA+DPYYYFQ+GWNIFD  
Sbjct: 764  VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823

Query: 788  IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            IV LSLMEL L+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 824  IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883

Query: 848  IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
            IIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 884  IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943

Query: 906  CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
            CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 944  CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003

Query: 966  IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
            I++G+ + K     F     +QR     KP     + +  +CIA                
Sbjct: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062

Query: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
               T    G        ++       +P   V VPIAV ESD ++   ++ +S    E S
Sbjct: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGS 1122

Query: 1074 SKQTPEDSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1132
              +  + S SEGST D+      +E++P +  ++  DP+ CFTEGCV+R  CC V+  + 
Sbjct: 1123 KDKLDDTSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEG 1179

Query: 1133 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1192
             GK WW LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+F
Sbjct: 1180 LGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVF 1239

Query: 1193 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1252
            TY+F+LEMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLR
Sbjct: 1240 TYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLR 1299

Query: 1253 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1312
            ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+  C N+
Sbjct: 1300 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNE 1359

Query: 1313 TEGDLPLNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMD 1369
            T  ++      VNNK++CE L   N T E+ W  VK+NFDNVGAGYLALLQVATFKGWMD
Sbjct: 1360 TS-EIRFEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMD 1417

Query: 1370 IMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ 1429
            IMYAAVDSR  +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQ
Sbjct: 1418 IMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ 1477

Query: 1430 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMV 1489
            DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMV
Sbjct: 1478 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMV 1537

Query: 1490 TMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSI 1549
            TMMVETD QS +  NIL  INL+FV  FT EC++K+ ALRHYYFT  WNIFDFVVVILSI
Sbjct: 1538 TMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSI 1597

Query: 1550 VGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1609
            VG  L+DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1598 VGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1657

Query: 1610 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669
            LFLVMFI+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN 
Sbjct: 1658 LFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR 1717

Query: 1670 GPPYC--DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEE 1727
             PP C  D   P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEE
Sbjct: 1718 -PPDCSLDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775

Query: 1728 STEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLP 1787
            S +PLSEDDF+ FYEIWEKFDP+ATQFIEY  L+DFADAL  PLR+ KPN I LI MDLP
Sbjct: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLP 1835

Query: 1788 MVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHE 1847
            MVSGDRIHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK E
Sbjct: 1836 MVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQE 1895

Query: 1848 EVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLG 1907
            EVSA+V+QRA+R HL +R      F+ ++   + L E     RE                
Sbjct: 1896 EVSAVVLQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE---------------- 1933

Query: 1908 PPSSSSISSTSFPPSYDSVTRATSDNLQ 1935
                 S  ST+  PSYDSVT+   +  Q
Sbjct: 1934 --KKESTPSTASLPSYDSVTKPEKEKQQ 1959


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1748 bits (4527), Expect = 0.0
 Identities = 895/1285 (69%), Positives = 1034/1285 (80%), Gaps = 35/1285 (2%)

Query: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575

Query: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635

Query: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695

Query: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755

Query: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815

Query: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871

Query: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931

Query: 1055 DTDDQEEDEENSLGTEEESSKQTPED----SCSEGSTADMTNTAELLEQIPDLGQDVKDP 1110
            D +   E+E ++  +E E SK+ P+     + S  STAD     E  E+  +   + + P
Sbjct: 932  DLEMPTEEETDTF-SEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQP 990

Query: 1111 EDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAF 1170
            E+CFTE CV+R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAF
Sbjct: 991  EECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1050

Query: 1171 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLV 1230
            EDIY+E+R+ I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++
Sbjct: 1051 EDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSII 1110

Query: 1231 SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1290
            SLVAN LG++E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIF
Sbjct: 1111 SLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIF 1170

Query: 1291 WLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDN 1350
            WLIFSIMGVNLFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DN
Sbjct: 1171 WLIFSIMGVNLFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDN 1229

Query: 1351 VGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNL 1410
            VG GYL+LLQVATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNL
Sbjct: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289

Query: 1411 FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDI 1470
            FIGVIIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+
Sbjct: 1290 FIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDL 1349

Query: 1471 VTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRH 1530
            VTKQAFD+TIM LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR 
Sbjct: 1350 VTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQ 1409

Query: 1531 YYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1590
            YYFT  WNIFDFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIR
Sbjct: 1410 YYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIR 1469

Query: 1591 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCL 1650
            TLLFALMMSLPALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CL
Sbjct: 1470 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICL 1529

Query: 1651 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIV 1709
            F+ITTSAGWDGLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIV
Sbjct: 1530 FEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIV 1589

Query: 1710 VNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSE 1769
            VNMYIAIILENF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L E
Sbjct: 1590 VNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQE 1649

Query: 1770 PLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAAN 1829
            PLRIAKPN+I LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAAN
Sbjct: 1650 PLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAAN 1709

Query: 1830 PSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAP 1888
            PSK+SYEPITTTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAP
Sbjct: 1710 PSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAP 1766

Query: 1889 EREGLIAYVMSENFSRPLGPPSSSS 1913
            E+EGL+A  MS+ +    G  SS S
Sbjct: 1767 EKEGLLANTMSKMYGHENGNSSSPS 1791



 Score =  597 bits (1539), Expect = e-170
 Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184

Query: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304

Query: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364

Query: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424

Query: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++ ++ +S         +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 226  ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194

Query: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227

Query: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282

Query: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1304
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173

Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232

Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631

Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238
              +  + + +  WN  D  ++ ++ V   +  +  LS LR+FR+LR  K     P L  
Sbjct: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688

Query: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
           ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 99   GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144
            GK IF        ++A   L    P  PI R   KI  +V+ L     F++ IM  I  N
Sbjct: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366

Query: 145  CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198
             V  M + D     K      +   F  I+T E ++K+LA    L  + F    WN  DF
Sbjct: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421

Query: 199  SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247
             V+I++ V   + L +L             +R  R+ R L+ I    G++T++ AL+ S+
Sbjct: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479

Query: 248  KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297
              L ++ +L    + ++++ G+  F    +   +    NF     +         S   D
Sbjct: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335
            GL+   L+    D +  L   GTS    CGN S  G C
Sbjct: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576



 Score = 39.3 bits (90), Expect = 0.038
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 1347 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1406
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437

Query: 1407 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477



 Score = 38.9 bits (89), Expect = 0.050
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451

Query: 944 ADNLTAPDEDRE 955
             N     ED+E
Sbjct: 452 EQNEATLAEDKE 463


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1462 bits (3784), Expect = 0.0
 Identities = 748/831 (90%), Positives = 752/831 (90%), Gaps = 42/831 (5%)

Query: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049
            QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI
Sbjct: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 750

Query: 1050 AVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKD 1109
            AVAESDTDDQEEDEENSLGTEEESSKQ      S G  A                     
Sbjct: 751  AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEA--------------------- 789

Query: 1110 PEDCFTEGCVRRCPCCAVDTT--QAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGA 1167
            P D  T   V        + +  QA  +  W+         E                  
Sbjct: 790  PPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE------------------ 831

Query: 1168 LAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV 1227
             AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV
Sbjct: 832  -AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV 890

Query: 1228 SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC 1287
            SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC
Sbjct: 891  SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC 950

Query: 1288 LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN 1347
            LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN
Sbjct: 951  LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN 1010

Query: 1348 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1407
            FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT
Sbjct: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070

Query: 1408 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
            LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI
Sbjct: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130

Query: 1468 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1527
            FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA
Sbjct: 1131 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1190

Query: 1528 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
            LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK
Sbjct: 1191 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1647
            GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM
Sbjct: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1310

Query: 1648 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1707
            LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL
Sbjct: 1311 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1370

Query: 1708 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1758
            IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1371 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421



 Score = 1249 bits (3233), Expect = 0.0
 Identities = 623/630 (98%), Positives = 626/630 (99%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1310
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1311 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1346 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1398
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1399 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198

Query: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258

Query: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313

Query: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373

Query: 932  NLFLALLLSSFS 943
            N+++A++L +FS
Sbjct: 1374 NMYIAIILENFS 1385



 Score = 88.2 bits (217), Expect = 7e-17
 Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)

Query: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++ ++ VS         +
Sbjct: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904

Query: 212  LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964

Query: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998

Query: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047

Query: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107

Query: 439  EML 441
            + L
Sbjct: 1108 KKL 1110



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173

Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232

Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292

Query: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882
                                                SD+G  P             H  
Sbjct: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352

Query: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412

Query: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
             ++   N     E  E         R Q  +  +K+
Sbjct: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086

Query: 947  LTAPDEDREMNNLQ 960
                 +D  M   Q
Sbjct: 1087 KKLGGQDIFMTEEQ 1100



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)

Query: 105  FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156
            ++A   L    P  PI R   K       I+    F++ IM  I  N V  M + D    
Sbjct: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163

Query: 157  TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207
             K      +   F AI+T E +VK+ A    L  + F    WN  DF V+I++ V    S
Sbjct: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218

Query: 208  ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262
            + I+    S      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278

Query: 263  VFALIGLQLF 272
            ++++ G+  F
Sbjct: 1279 IYSIFGMANF 1288


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1369 bits (3544), Expect = 0.0
 Identities = 734/1310 (56%), Positives = 923/1310 (70%), Gaps = 88/1310 (6%)

Query: 616  SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
            S  LR    + PP + +  +    PQ+L      SQ   +D F+E G    RQRALSAVS
Sbjct: 468  SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527

Query: 668  VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
            +LT  ++E E+S+  C PC   LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 528  ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587

Query: 728  VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
            ++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM  KIIALDPY+YF++GWNIFDSI
Sbjct: 588  IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647

Query: 788  IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
            + +LS  ++    +   S   LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 648  VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707

Query: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
            L I++FIF+VVGMQLFG++++  +              L  WHM DF+H+FL++FRILCG
Sbjct: 708  LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767

Query: 898  EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
            EWIE MW+CM+ +    SLC++VF+L+ VIG LVVLNLF+ALLL+SFS +      E + 
Sbjct: 768  EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827

Query: 955  EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
                +QLAL R +R   FV+ T   FC    R++    QK  A     Q    I     P
Sbjct: 828  RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882

Query: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTD----------DQEE 1061
               E ++   T++E           G   D   +  P+A  E D +           Q E
Sbjct: 883  LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941

Query: 1062 DEENSLGTEEESSKQTPE-------DSCSEGST----------ADMTN------TAELLE 1098
             E+ +    +E+ K T +       D  SE             +D+T+      T +L +
Sbjct: 942  PEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQD 1001

Query: 1099 QIPDLGQDV--KDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETF 1156
                L + V  K PE C  +G     PCC+VD  + P  +WW LRKTCY IV+HSWFE+F
Sbjct: 1002 GFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESF 1061

Query: 1157 IIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNA 1216
            IIF+ILLSSGAL FED++LE +  I+ LL   D +FT++F+LEM+LKWVA+GF KYFT+A
Sbjct: 1062 IIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSA 1121

Query: 1217 WCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1276
            WC LDF+IV VS+ +L+        +  +KS RTLRALRPLRALS+FEGM+VVVNAL+GA
Sbjct: 1122 WCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGA 1174

Query: 1277 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLT 1336
            IP+I+NVLLVCLIFWL+F I+GV  F+GKFG+CIN T  D  +NYTI+ NKSQCES    
Sbjct: 1175 IPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--DSVINYTIITNKSQCES---- 1228

Query: 1337 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1396
            G   W   KVNFDNVG  YLALLQVATFKGWMDI+YAAVDS   E+QP++E N   YIYF
Sbjct: 1229 GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYF 1288

Query: 1397 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1456
            V+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1289 VVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1348

Query: 1457 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1516
            PRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+ +Q     +IL  +N +FV I
Sbjct: 1349 PRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVI 1408

Query: 1517 FTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLA 1574
            FT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S +  +    F PTLFR++RLA
Sbjct: 1409 FTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLA 1468

Query: 1575 RIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGI 1634
            RIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIY+I GM  F+ V  E+GI
Sbjct: 1469 RIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGI 1528

Query: 1635 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVG 1694
            DD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L         +  + N S  +C  P + 
Sbjct: 1529 DDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIA 1580

Query: 1695 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1754
              +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL EDDFD+FYE+WEKFDPEATQF
Sbjct: 1581 TSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQF 1640

Query: 1755 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1814
            I+YS LSDFADAL EPLR+AKPN+   + MDLPMVS DR+HCMDILFAFT RVLG S  +
Sbjct: 1641 IKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGL 1700

Query: 1815 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQ 1864
            D++K  MEEKFM ANP K  YEPI TT +RK EE  A +IQ+AFR+++++
Sbjct: 1701 DSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750



 Score =  453 bits (1166), Expect = e-127
 Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)

Query: 12  SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
           +FR FT +SLAAIEKR+A ++ +     ++S++   E   PRPQLDL+AS+KLP LYG+ 
Sbjct: 15  NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69

Query: 72  PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
           P+ELIG+PLEDLDPFY   KTF+VLN+ +TI+RFSA +AL++  PF+ IR  A+++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
           LF+M I+ T++ NCVFMA    ++     T   E  FT IY FE+L+KILARGF L  F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
           FLRDPWNWLD  VI +A VS    I +  L  LRTFRV RALK ISV+  LK IVGAL++
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248

Query: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
           SVKKL +V++LT FCLS+FAL+G QLFMG+L  KC+                        
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289

Query: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
             +S+PE Y      K  + +  +CG       C   Y C     NPD+ YT+FD+F W+
Sbjct: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
           FLA+FRLMTQD WE+LYQQTLR+ G   + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408

Query: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
              AE E KEK FQEA ++LK+E EAL   G+D  S +SLE S   P     +    +KR
Sbjct: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466

Query: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
            S    E G+D+ P SDS ED  +    L  T+ LS+
Sbjct: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503



 Score =  105 bits (263), Expect = 3e-22
 Identities = 148/756 (19%), Positives = 287/756 (37%), Gaps = 133/756 (17%)

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
            +++N +FMA      ++       +   VFTGI+  E   KI+A    LD + + +  WN
Sbjct: 139  VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196

Query: 783  IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
              DSI++ ++++         L  LR+FR+ R  K       L  ++  +  SV  L N+
Sbjct: 197  WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256

Query: 843  TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
             ++    + IFA+VG QLF             KN S     D                  
Sbjct: 257  IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316

Query: 873  --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
                          + + P ++  +F +   +FL +FR++  +  E ++     +     
Sbjct: 317  MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376

Query: 916  LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
            +  F++V+ +G+  ++NL LA++  ++   N     E                     K 
Sbjct: 377  VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418

Query: 976  TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
              +     LL++  +   A+       + + T Y    P+  K+   +K   F   E   
Sbjct: 419  KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476

Query: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTADMTNTAE 1095
               PG             SD+D+  + +   L   +  S+    D   E    D      
Sbjct: 477  DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDE--HGDPLQRQR 521

Query: 1096 LLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWR-------LRKTCYHIV 1148
             L  +  L   +K+ E         + PC       A   + W        ++K    ++
Sbjct: 522  ALSAVSILTITMKEQEK-------SQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVM 574

Query: 1149 EHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYG 1208
               + E  I   I++++  LA E   +E   + + +L   + +FT +F+ EM LK +A  
Sbjct: 575  TDPFTELAITICIIINTVFLAMEHHKME--ASFEKMLNIGNLVFTSIFIAEMCLKIIALD 632

Query: 1209 FKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRV 1268
               YF   W   D ++  +S   ++   L       ++S R LR  +  ++      +  
Sbjct: 633  PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIK 692

Query: 1269 VVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKS 1328
            ++   VGA+ S + V+LV +IF  IFS++G+ LF   F                  N++ 
Sbjct: 693  IIGNSVGALGS-LTVVLVIVIF--IFSVVGMQLFGRSF------------------NSQK 731

Query: 1329 QCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEY 1388
              +  N TG         +  +    +L + ++   + W++ M+  +             
Sbjct: 732  SPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS----- 785

Query: 1389 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1424
                 I F++  + G    LNLFI +++++F+ +++
Sbjct: 786  --LCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)

Query: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
            +R     +  HS F  FII  ++++   +A             +    A+ +FT +++ E
Sbjct: 118  IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173

Query: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255
             L+K +A GF      +  + W WLD +++ +++VS +           +  LRT R  R
Sbjct: 174  ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228

Query: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1314
             L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G    +CI++  
Sbjct: 229  ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288

Query: 1315 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1354
             ++  P  Y     K +       C       + ++  E   TK+       NFDN G  
Sbjct: 289  KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 1355 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1414
            +LA+ ++ T   W  +    + + G          LY   +F++ I  GSF+ +NL + V
Sbjct: 349  FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398

Query: 1415 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1451
            +   + +Q K +  +   +  ++K +  A + L  +K
Sbjct: 399  VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
            +R+   +I+ HS F   I+  IL +    +F   H  + P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
             ++K +A GF      +    W  LDF ++I++ V+  I L  L + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159

Query: 232  VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+      NGT+
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212

Query: 292  GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
              +                  NY +    S                  +C     +  + 
Sbjct: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236

Query: 352  YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
              +FD+   A+LAL ++ T   W  +           QQ    +  +  I+F++ I  GS
Sbjct: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296

Query: 402  FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
            F+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)

Query: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +++    ++      + I   I+ N VF+A         + +        FT+I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
           +KI+A    L  + + R  WN  D  V ++++    N  L   S   LR+FRVLR  K  
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681

Query: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
              P L T++  +  SV  L  + V+ V  + +F+++G+QLF         R+F      
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727

Query: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
                                      N      LC  +    +C   +           
Sbjct: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750

Query: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
                  F  +FL +FR++  +  E +++  Q   ++  + +I F+L+  +G   ++NL 
Sbjct: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806

Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
           +A++  ++  + +    E E ++ + Q A++  ++
Sbjct: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)

Query: 116  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
            P +  +     I+   +F+++I+  I+ N + M    ++ P   K    ++ + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 170  FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
             E L+KI    F L  + F  + WN  D  V++++ VS  I  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 219  RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)

Query: 1459 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1518
            P N  +     +     F + I+  + +N V M       S      +A+   +F  I+ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1519 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1573
             E ++K+ A         +  + WN  D +V+ ++IV  +    I+        FRV R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229

Query: 1574 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1610
             +           +G +LR ++    +  L F   +S+ AL    L +            
Sbjct: 230  LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288

Query: 1611 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1646
                                 F +  I+      +  Y      I+  +N+  F N   S
Sbjct: 289  KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 1647 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1706
             L +F++ T   W+ L    L T   Y                     + FF   I +  
Sbjct: 349  FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388

Query: 1707 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1756
              ++N+ +A++    ++A EE  + ++ +      E  EK   EA Q ++
Sbjct: 389  FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429



 Score = 31.6 bits (70), Expect = 8.0
 Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)

Query: 347  NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
            NP+ G     +F +FA + L LF++ T   W+ L    LRS               I   
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
            +F+  I +    +VN+ +AV+    E  N AT
Sbjct: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1139 bits (2946), Expect = 0.0
 Identities = 601/1213 (49%), Positives = 811/1213 (66%), Gaps = 40/1213 (3%)

Query: 674  EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
            EELE+S+  CP  W + A+ +LIW C P W+ +K+ V  ++M PFTDL + +CI+LN  F
Sbjct: 462  EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521

Query: 734  MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
            + LEHY M+ +   +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV   L
Sbjct: 522  LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581

Query: 794  MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
            +EL L+ ++ +++LR FR+LR+FKL K WPT   L+  + NS  AL +L L+L   +F  
Sbjct: 582  IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641

Query: 854  AVVGMQLFGKNYSELR---DSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
            A  GM+LFGKNY E     D D  L PRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 642  AAFGMKLFGKNYEEFVCHIDKDCQL-PRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700

Query: 911  GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
            GQS C+  +L+V++IGNL+VL LFLAL+ S  S  ++TA +E+ E  NLQLA+ARI++G+
Sbjct: 701  GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759

Query: 971  RFV-----------KRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKV 1019
             +V            + T D    +  +       L+        +         + EK 
Sbjct: 760  NYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLK--------DKEKS 811

Query: 1020 PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPE 1079
              T K     E +      P       VPIA  ESD ++ +  E  S   +  S ++  +
Sbjct: 812  SGTEKNATENESQSL---IPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQ 868

Query: 1080 DSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWR 1139
             S SE ST D+  + E  E++   G+  K  ++    GC R      +      GK+W  
Sbjct: 869  SSSSECSTVDIAISEE--EEMFYGGERSKHLKN----GCRRGSSLGQISGASKKGKIWQN 922

Query: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
            +RKTC  IVE++WF+ FI  + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LE
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 1200 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1259
            MLLKW+AYGFK YF+N W  LDF++V V  +SL+  T        +K L +++ LRPLR 
Sbjct: 983  MLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRV 1037

Query: 1260 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPL 1319
            LS+FE M+VVV AL+      +NV LVCL+ WLIFSIMGV+LFAG+F  CI+ T G+   
Sbjct: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGER-F 1096

Query: 1320 NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRG 1379
              + V NKS+CESL     + W   K+NFDNVG G+L+LLQVATF GW+ IM +A+DS  
Sbjct: 1097 PSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVA 1156

Query: 1380 YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1439
               QP +E N+YMY YF+ FIIFG F  L++ I VIIDNFN+ K KLGG +IF+T +Q+K
Sbjct: 1157 VNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRK 1216

Query: 1440 YYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQS 1499
             Y  +KKL  +  Q+P+PRPLNK QGFIFD+VT QAF+V +M LIC   + MM++TD QS
Sbjct: 1217 QYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQS 1276

Query: 1500 PEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ 1559
             +    L  IN +FV ++T ECI+KL A R +YFT +WNIFDF+VVI SI G  L   + 
Sbjct: 1277 LQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVG 1336

Query: 1560 KYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSI 1619
             Y   P+L ++I L+RI  +LRL +G K    L+  LM+SLPAL NI LL+FLVMFIY++
Sbjct: 1337 SYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAV 1396

Query: 1620 FGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
            FGM NFAYVK EAGI+D+ NF+TF NSMLCLFQ+   AGWDG+L  I N+    CDP   
Sbjct: 1397 FGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKI 1456

Query: 1680 NSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFD 1738
            N     RGDCG+P+VGI +F +YI+IS+LI+VNMYI +++E  ++A+++  + LSEDDF 
Sbjct: 1457 NPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFR 1516

Query: 1739 MFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMD 1798
             F+++W++FDP+ TQ+I+ S LSDFA AL  PL +AKPN+  LI +DLPM  GDRIHC+D
Sbjct: 1517 KFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLD 1576

Query: 1799 ILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAF 1858
            IL AFTKRV+G+   M+ +  ++E  F+ ANP KI+ EPITTTL+RK E VSA +IQRA+
Sbjct: 1577 ILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAY 1636

Query: 1859 RRHLLQRSLKHAS 1871
            + + L+R+ K+ S
Sbjct: 1637 KNYRLRRNDKNTS 1649



 Score =  381 bits (979), Expect = e-105
 Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)

Query: 16  FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
           FT+ES   I++ +A+       T  E  E    EE  +P  DL+  KKLP +YGN  Q +
Sbjct: 13  FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61

Query: 76  IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
           + EPLED+DP+Y  +K TFIVLNK +TIFRF+A + L  LSPF+ IRR  +K+LVH  F 
Sbjct: 62  VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121

Query: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
           + I+ ++L +CVFM+  + P W   +E T   IYTFE LVK+ ARG    +F+FL DPWN
Sbjct: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181

Query: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
           WLDFSV +   +     L  +  L+T R LR LK I +  GLK++VG LI  +K+L  V+
Sbjct: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241

Query: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
           +LT+F LS+F+LIG+ LFMGNL+HKC R      N T  N T                Y+
Sbjct: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289

Query: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
            + EN+    G    LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA  ALFRL
Sbjct: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349

Query: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
           M QD  E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q     ++
Sbjct: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409

Query: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
           + E +FQ+  + L++ +E       D      +EM   +P+++
Sbjct: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446



 Score =  132 bits (332), Expect = 3e-30
 Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)

Query: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
            +R+T   ++ H +F+ FI+  +L+    ++  ++     K   VL      ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162

Query: 1200 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1259
            +  + V  G   +  + W WLDF +    ++      + ++ +  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1260 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1318
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G    +C    +    
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272

Query: 1319 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1375
                    +++ E+L N TG  Y+ +   NF  + G  Y  L    T  G     Y  V 
Sbjct: 273  --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324

Query: 1376 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1406
                        DS G+          ++ P+  Y+  +Y       I+FV+     SF+
Sbjct: 325  AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384

Query: 1407 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1449
              +LF+G++   + ++K+++G                 Q+   T+E K     MKK    
Sbjct: 385  MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444

Query: 1450 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1473
                                +K +K  P    K+                + F+  I+  
Sbjct: 445  STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504

Query: 1474 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1532
               D+ ++  I LN+  + +E    S +   +L   NL+F+ IFT E I K+ A+  Y Y
Sbjct: 505  PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564

Query: 1533 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1592
            F   WNIFD ++V   ++   L+++            ++RL R+ RI +L +     + L
Sbjct: 565  FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616

Query: 1593 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1645
            +++L  S  AL ++ LLLF  +F  + FGM  F   Y ++   ID       ++   F +
Sbjct: 617  MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676

Query: 1646 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1705
            S L +F+I      + L   +   G  +C P                    F+   I+I 
Sbjct: 677  SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716

Query: 1706 FLIVVNMYIAIILENFS----VATEESTE 1730
             L+V+ +++A++  +FS    V  EE+ E
Sbjct: 717  NLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)

Query: 646  QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
            Q+   DG  +   +Q + S  S +  A+ E EE       S+H    C   + L Q    
Sbjct: 854  QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913

Query: 697  WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
             +   +W +I++    +V + +    I +  +L+T  +A E   M      + +L+  ++
Sbjct: 914  SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973

Query: 755  VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
            +FT IF  EM  K +A     YF  GW   D ++VI+  + L       L  L S + LR
Sbjct: 974  IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033

Query: 815  VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
              ++   +  +  +++ +  +     N+ LV  +I  IF+++G+ LF   + E  D  SG
Sbjct: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)

Query: 120  IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
            IR+   KI+ ++ F   I + T+L+        ++M Q        +Y +  FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
             L+K +A GF      +  + W  LDF V+I+  +S   K    L  L + + LR L+ +
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038

Query: 231  SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
            S    +K +V ALI++     +V ++ +    +F+++G+ LF G       R +  ++ T
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091

Query: 291  NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
            +G                  P + ++     + LL   S                EN   
Sbjct: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120

Query: 351  GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
               +FD+    FL+L ++ T + W  +    + S            IYM  +F+  I  G
Sbjct: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180

Query: 401  SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
             F  +++++ V+   + +       + I  T ++ K+++   +++ ++ +
Sbjct: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)

Query: 48  EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
           E+   R + +L+ SKK+  LY                 +Y   KTF++ N      +   
Sbjct: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496

Query: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
                +++PF  +               LI+C IL  C    +H P              
Sbjct: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542

Query: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
            F  I+T E + KI+A    +H + + +  WN  D  ++    +   +  +  ++ LR F
Sbjct: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598

Query: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
           R+LR  K     P  + ++ +L  S   L D+++L    +   A  G++LF  N
Sbjct: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)

Query: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
           V++ PF  L I + ++++ +FM+L      +   +   V      GI+T E+  K+ A  
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167

Query: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
                + +    WN  D  + +  ++ +  S +  +  L++ R LR+ K+      L +L
Sbjct: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226

Query: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
           + ++ + +  L  + ++    + IF+++GM LF  N
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  448 bits (1152), Expect = e-125
 Identities = 314/1130 (27%), Positives = 547/1130 (48%), Gaps = 132/1130 (11%)

Query: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837

Query: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897

Query: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957

Query: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016

Query: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCC------GLLRQR--- 988
             F A+   N +  DED+   + +    +    LR ++ T    C       G L  R   
Sbjct: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCSLAVTPNGHLEGRGSL 1072

Query: 989  ---------------PQKPAALAAQGQLP-SCIATPYSPPPPETEKVPP----------- 1021
                           P+    L A   LP S   +  S  PP  ++ PP           
Sbjct: 1073 SPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132

Query: 1022 -------TRKETRFEEGEQPG---QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
                   +R+ +    G  P    +G  G+ E +       +  TDD+ ED   + G   
Sbjct: 1133 GPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLS--GEGKGSTDDEAEDGRAAPGPRA 1190

Query: 1072 ESSKQT-------------PEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGC 1118
               ++              P   C +     +   ++   +I    +D  + +D   + C
Sbjct: 1191 TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSC 1250

Query: 1119 VRRCPCCAVDTTQAPGKVWW----------------RLRKTCYHIVEHSWFETFIIFMIL 1162
                 C  +     P K  W                R R +C  ++ H  F+  ++  I 
Sbjct: 1251 -----CLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIF 1305

Query: 1163 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKK----YFTNAWC 1218
            L+   +A E   ++   T +V L  ++ +FT +FV EM++K VA G       Y  ++W 
Sbjct: 1306 LNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWN 1365

Query: 1219 WLDFLIVDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1275
             LD L+V VSLV +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ 
Sbjct: 1366 LLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLIS 1425

Query: 1276 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNL 1335
            ++  I N++L+C  F++IF I+GV LF GKF  C    EG    N   ++ K+QC + + 
Sbjct: 1426 SLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC----EGPDTRN---ISTKAQCRAAHY 1478

Query: 1336 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1395
                 W + K NFDN+G   ++L  +++  GW++IMY  +D+ G ++QP   +N +M +Y
Sbjct: 1479 R----WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLY 1534

Query: 1396 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1455
            F+ F++  SFF LN+F+GV+++NF++ ++    ++    EE  K    +++   K  ++P
Sbjct: 1535 FISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--KRLRRLERRRRKAQRRP 1592

Query: 1456 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1515
                 +  +  I  + T    D+ I F+IC+N++TM +E  +Q       L   N +F  
Sbjct: 1593 YYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTI 1652

Query: 1516 IFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1572
            +F  E  +KL A     +F + WN  D  +V+LS++G  L +I        +PT+ R++R
Sbjct: 1653 VFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 1573 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE- 1631
            + RI R+L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  ++   
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSE 1772

Query: 1632 ----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGD 1687
                 G+     F  F  + L LF+++T   W+G++             TL   +     
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMK-----------DTLRECSREDKH 1821

Query: 1688 CGS--PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1735
            C S  PA+  ++F T+++++  ++VN+ +A+++++   + +E+ E    D
Sbjct: 1822 CLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELD 1871



 Score =  145 bits (366), Expect = 4e-34
 Identities = 203/889 (22%), Positives = 354/889 (39%), Gaps = 190/889 (21%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL--GNLSALRTFRVLRALKTISVIPGLK 237
            G       ++R+P+N  D  +I++  V E +    G LS LRTFR+LR LK +  +P L+
Sbjct: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
                            + LK  T D +                       PD    +FDS
Sbjct: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019

Query: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079

Query: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138

Query: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176

Query: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214

Query: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270

Query: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329

Query: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389

Query: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449

Query: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509

Query: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  114 bits (286), Expect = 7e-25
 Identities = 81/316 (25%), Positives = 150/316 (47%), Gaps = 24/316 (7%)

Query: 674  EELEESRHKCPPCWNRLAQRYLIWECCPLWMSI---KQGVKLVVMDPFTDLTITMCIVLN 730
            +E EE+R +      RL +R    +  P +      ++ +  +    + DL IT  I +N
Sbjct: 1565 QEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVN 1624

Query: 731  TLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVI 790
             + M++EHYN     +E L+  N VFT +F  E   K++A     +F+  WN  D  IV+
Sbjct: 1625 VITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL 1684

Query: 791  LSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            LSLM + L  +          + + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1685 LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1744

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W 899
            NL L+  ++ FI+A +G++LFG+      +   GL       +F  AFL +FR+  G+ W
Sbjct: 1745 NLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW 1804

Query: 900  IETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTA 949
               M D +    +          +L  + F+  +++   V++N+ +A+L+      N  A
Sbjct: 1805 NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA 1864

Query: 950  PDEDREMNNLQLALAR 965
             ++      ++L +A+
Sbjct: 1865 REDAELDAEIELEMAQ 1880



 Score =  112 bits (281), Expect = 3e-24
 Identities = 89/356 (25%), Positives = 170/356 (47%), Gaps = 49/356 (13%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN--LSALRTFRVLRAL 227
            E ++K++A G       +L D WN LDF +++   +  ++   N  LSA+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267

Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323

Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383

Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439



 Score =  108 bits (270), Expect = 5e-23
 Identities = 89/362 (24%), Positives = 158/362 (43%), Gaps = 79/362 (21%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------L 212
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++ V   +          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            G L  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
             G                                Y   P+               N S  
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470

Query: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523

Query: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581

Query: 442  KK 443
            ++
Sbjct: 1582 ER 1583



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1248
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198

Query: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1307
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258

Query: 1308 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1340
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318

Query: 1341 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378

Query: 1379 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435

Query: 1436 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 1134 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1193
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1194 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1253
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888

Query: 1254 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1313
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946

Query: 1314 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1373
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981

Query: 1374 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1422
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 1463 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1522
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1523 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1578
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1579 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1633
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1634 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1693
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990

Query: 1694 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1742
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 40/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSA-----------LR 219
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 220  TFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1525
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1526 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1581
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208

Query: 1582 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1832

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 1833 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1869



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  444 bits (1141), Expect = e-124
 Identities = 314/1135 (27%), Positives = 548/1135 (48%), Gaps = 136/1135 (11%)

Query: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837

Query: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897

Query: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957

Query: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016

Query: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCC------GLLRQR--- 988
             F A+   N +  DED+   + +    +    LR ++ T    C       G L  R   
Sbjct: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCSLAVTPNGHLEGRGSL 1072

Query: 989  ---------------PQKPAALAAQGQLP-SCIATPYSPPPPETEKVPP----------- 1021
                           P+    L A   LP S   +  S  PP  ++ PP           
Sbjct: 1073 SPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132

Query: 1022 -------TRKETRFEEGEQPG---QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
                   +R+ +    G  P    +G  G+ E +       +  TDD+ ED   + G   
Sbjct: 1133 GPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLS--GEGKGSTDDEAEDGRAAPGPRA 1190

Query: 1072 ESSKQT-------------PEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGC 1118
               ++              P   C +     +   ++   +I    +D  + +D   + C
Sbjct: 1191 TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSC 1250

Query: 1119 VRRCPCCAVDTTQAPGKVWW----------------RLRKTCYHIVEHSWFETFIIFMIL 1162
                 C  +     P K  W                R R +C  ++ H  F+  ++  I 
Sbjct: 1251 -----CLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIF 1305

Query: 1163 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKK----YFTNAWC 1218
            L+   +A E   ++   T +V L  ++ +FT +FV EM++K VA G       Y  ++W 
Sbjct: 1306 LNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWN 1365

Query: 1219 WLDFLIVDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1275
             LD L+V VSLV +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ 
Sbjct: 1366 LLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLIS 1425

Query: 1276 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNL 1335
            ++  I N++L+C  F++IF I+GV LF GKF  C    EG    N   ++ K+QC + + 
Sbjct: 1426 SLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC----EGPDTRN---ISTKAQCRAAHY 1478

Query: 1336 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1395
                 W + K NFDN+G   ++L  +++  GW++IMY  +D+ G ++QP   +N +M +Y
Sbjct: 1479 R----WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLY 1534

Query: 1396 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP--- 1452
            F+ F++  SFF LN+F+GV+++NF++ ++    ++     E+K+     ++  S  P   
Sbjct: 1535 FISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKRLRRLERRRRSTFPSPE 1593

Query: 1453 --QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKIN 1510
              ++P     +  +  I  + T    D+ I F+IC+N++TM +E  +Q       L   N
Sbjct: 1594 AQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCN 1653

Query: 1511 LLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTL 1567
             +F  +F  E  +KL A     +F + WN  D  +V+LS++G  L +I        +PT+
Sbjct: 1654 YVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTI 1713

Query: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627
             R++R+ RI R+L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  
Sbjct: 1714 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1773

Query: 1628 VKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSN 1682
            ++        G+     F  F  + L LF+++T   W+G++             TL   +
Sbjct: 1774 LECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMK-----------DTLRECS 1822

Query: 1683 GSRGDCGS--PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1735
                 C S  PA+  ++F T+++++  ++VN+ +A+++++   + +E+ E    D
Sbjct: 1823 REDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELD 1877



 Score =  145 bits (366), Expect = 4e-34
 Identities = 203/889 (22%), Positives = 354/889 (39%), Gaps = 190/889 (21%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL--GNLSALRTFRVLRALKTISVIPGLK 237
            G       ++R+P+N  D  +I++  V E +    G LS LRTFR+LR LK +  +P L+
Sbjct: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
                            + LK  T D +                       PD    +FDS
Sbjct: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019

Query: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079

Query: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138

Query: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176

Query: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214

Query: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270

Query: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329

Query: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389

Query: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449

Query: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509

Query: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  112 bits (281), Expect = 3e-24
 Identities = 89/356 (25%), Positives = 170/356 (47%), Gaps = 49/356 (13%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN--LSALRTFRVLRAL 227
            E ++K++A G       +L D WN LDF +++   +  ++   N  LSA+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267

Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323

Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383

Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439



 Score =  112 bits (281), Expect = 3e-24
 Identities = 73/269 (27%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I +N + M++EHYN     +E L+  N VFT +F  E   K++A     +F
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            +  WN  D  IV+LSLM + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      +   GL       +F  A
Sbjct: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMA 1797

Query: 888  FLIIFRILCGE-WIETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLA 936
            FL +FR+  G+ W   M D +    +          +L  + F+  +++   V++N+ +A
Sbjct: 1798 FLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1857

Query: 937  LLLSSFSADNLTAPDEDREMNNLQLALAR 965
            +L+      N  A ++      ++L +A+
Sbjct: 1858 VLMKHLEESNKEAREDAELDAEIELEMAQ 1886



 Score =  108 bits (271), Expect = 4e-23
 Identities = 89/366 (24%), Positives = 159/366 (43%), Gaps = 79/366 (21%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------L 212
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++ V   +          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            G L  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
             G                                Y   P+               N S  
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470

Query: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523

Query: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581

Query: 442  KKEHEA 447
            ++   +
Sbjct: 1582 ERRRRS 1587



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1248
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198

Query: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1307
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258

Query: 1308 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1340
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318

Query: 1341 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378

Query: 1379 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435

Query: 1436 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 1134 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1193
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1194 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1253
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888

Query: 1254 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1313
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946

Query: 1314 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1373
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981

Query: 1374 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1422
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 1463 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1522
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1523 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1578
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1579 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1633
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1634 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1693
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990

Query: 1694 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1742
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 40/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662

Query: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSA-----------LR 219
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718

Query: 220  TFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1525
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1526 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1581
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208

Query: 1582 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  436 bits (1120), Expect = e-121
 Identities = 313/1131 (27%), Positives = 557/1131 (49%), Gaps = 133/1131 (11%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ- 1453
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q 
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQM 1551

Query: 1454 -----KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAK 1508
                 KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   K
Sbjct: 1552 AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALK 1610

Query: 1509 I-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFS 1564
            I N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +
Sbjct: 1611 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 1670

Query: 1565 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN 1624
            PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  
Sbjct: 1671 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 1730

Query: 1625 FAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
            F  ++ +      G+     F+ F  + L LF+++T   W+G++   L      CD    
Sbjct: 1731 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD---- 1782

Query: 1680 NSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
                    C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1783 ----QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  436 bits (1120), Expect = e-121
 Identities = 313/1131 (27%), Positives = 557/1131 (49%), Gaps = 133/1131 (11%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ- 1453
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q 
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQM 1551

Query: 1454 -----KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAK 1508
                 KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   K
Sbjct: 1552 AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALK 1610

Query: 1509 I-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFS 1564
            I N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +
Sbjct: 1611 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 1670

Query: 1565 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN 1624
            PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  
Sbjct: 1671 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 1730

Query: 1625 FAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
            F  ++ +      G+     F+ F  + L LF+++T   W+G++   L      CD    
Sbjct: 1731 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD---- 1782

Query: 1680 NSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
                    C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1783 ----QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  436 bits (1120), Expect = e-121
 Identities = 313/1131 (27%), Positives = 557/1131 (49%), Gaps = 133/1131 (11%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ- 1453
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q 
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQM 1551

Query: 1454 -----KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAK 1508
                 KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   K
Sbjct: 1552 AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALK 1610

Query: 1509 I-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFS 1564
            I N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +
Sbjct: 1611 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 1670

Query: 1565 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN 1624
            PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  
Sbjct: 1671 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 1730

Query: 1625 FAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
            F  ++ +      G+     F+ F  + L LF+++T   W+G++   L      CD    
Sbjct: 1731 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD---- 1782

Query: 1680 NSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
                    C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1783 ----QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score =  436 bits (1120), Expect = e-121
 Identities = 313/1131 (27%), Positives = 557/1131 (49%), Gaps = 133/1131 (11%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ- 1453
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q 
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQM 1551

Query: 1454 -----KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAK 1508
                 KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   K
Sbjct: 1552 AEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALK 1610

Query: 1509 I-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFS 1564
            I N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +
Sbjct: 1611 ICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPIN 1670

Query: 1565 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN 1624
            PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  
Sbjct: 1671 PTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVEL 1730

Query: 1625 FAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
            F  ++ +      G+     F+ F  + L LF+++T   W+G++   L      CD    
Sbjct: 1731 FGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD---- 1782

Query: 1680 NSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
                    C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1783 ----QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/364 (23%), Positives = 155/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score =  435 bits (1119), Expect = e-121
 Identities = 311/1125 (27%), Positives = 554/1125 (49%), Gaps = 128/1125 (11%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1454
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE  K    ++K   K   K
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE--KRLRRLEKKRRKAQCK 1550

Query: 1455 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLF 1513
            P     ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F
Sbjct: 1551 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIF 1609

Query: 1514 VAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRV 1570
              IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R+
Sbjct: 1610 TVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI 1669

Query: 1571 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKW 1630
            +R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ 
Sbjct: 1670 MRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLEC 1729

Query: 1631 E-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSR 1685
            +      G+     F+ F  + L LF+++T   W+G++   L      CD          
Sbjct: 1730 DETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QE 1777

Query: 1686 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1730
              C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1778 STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  119 bits (297), Expect = 4e-26
 Identities = 88/311 (28%), Positives = 148/311 (47%), Gaps = 21/311 (6%)

Query: 674  EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLV---VMDPFTDLTITMCIVLN 730
            +E EE+R +      RL ++    +C P +    +   LV       + DL IT  I LN
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1583

Query: 731  TLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVI 790
             + MA+EHY      +E L++ N +FT IF  E  FK++A     +FQ  WN  D  IV+
Sbjct: 1584 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1643

Query: 791  LSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            LS+M + L  +          + + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1644 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1703

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W 899
            NL L+  ++ FIFA +G++LFG    +      GL       +F  AFL +FR+  G+ W
Sbjct: 1704 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1763

Query: 900  IETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952
               M D + +   +S C       + F+  ++    V++N+ +A+L+      N  A +E
Sbjct: 1764 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1823

Query: 953  DREMNNLQLAL 963
                  L+L +
Sbjct: 1824 AELEAELELEM 1834



 Score =  103 bits (256), Expect = 2e-21
 Identities = 87/361 (24%), Positives = 154/361 (42%), Gaps = 79/361 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  E 444
            +
Sbjct: 1543 K 1543



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1560 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1619

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1620 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1675

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1676 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1720

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1721 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1740

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1741 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1798

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1799 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1845



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score =  430 bits (1106), Expect = e-120
 Identities = 313/1141 (27%), Positives = 556/1141 (48%), Gaps = 142/1141 (12%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE------QKKYYNAM---- 1444
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE      +KK  N M    
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDV 1552

Query: 1445 ------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ 1498
                      S+   KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q
Sbjct: 1553 IASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQ 1611

Query: 1499 SPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSD 1556
             P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +
Sbjct: 1612 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEE 1671

Query: 1557 I--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1614
            I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ 
Sbjct: 1672 IEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLF 1731

Query: 1615 FIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669
            FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++   L  
Sbjct: 1732 FIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD 1791

Query: 1670 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1729
                CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ 
Sbjct: 1792 ----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1839

Query: 1730 E 1730
            E
Sbjct: 1840 E 1840



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1829 KHLEESNKEAKEEAELEAELELEM 1852



 Score =  104 bits (260), Expect = 7e-22
 Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1543 KRRNLMLDDV 1552



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score =  430 bits (1106), Expect = e-120
 Identities = 313/1141 (27%), Positives = 556/1141 (48%), Gaps = 142/1141 (12%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE------QKKYYNAM---- 1444
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE      +KK  N M    
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDV 1552

Query: 1445 ------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ 1498
                      S+   KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q
Sbjct: 1553 IASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQ 1611

Query: 1499 SPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSD 1556
             P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +
Sbjct: 1612 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEE 1671

Query: 1557 I--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1614
            I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ 
Sbjct: 1672 IEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLF 1731

Query: 1615 FIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669
            FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++   L  
Sbjct: 1732 FIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD 1791

Query: 1670 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1729
                CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ 
Sbjct: 1792 ----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1839

Query: 1730 E 1730
            E
Sbjct: 1840 E 1840



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1829 KHLEESNKEAKEEAELEAELELEM 1852



 Score =  104 bits (260), Expect = 7e-22
 Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1543 KRRNLMLDDV 1552



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score =  430 bits (1106), Expect = e-120
 Identities = 313/1141 (27%), Positives = 556/1141 (48%), Gaps = 142/1141 (12%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSAD----------NLTAPDEDREMNNLQLALARIQRG---------------------L 970
            F A+          +  +P  D +  + +  LA +  G                     +
Sbjct: 967  FQAEGDANKSESEPDFFSPSLDGD-GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPM 1025

Query: 971  RFVKRTTWDF--CCGLLRQRPQ-----KPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
               K T+       G   +R       +P A       PS  ++P+SP    +     +R
Sbjct: 1026 SLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT--SR 1083

Query: 1024 KETRFEEGEQPG--QGTPGDPEPVCVPIAVAESDTDDQEEDEEN------------SLGT 1069
            + +R   G  P   + +P       +     ES  +++  +EE             SL  
Sbjct: 1084 RSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLER 1143

Query: 1070 EEESSKQTPED--------------SCSE-----GSTADMTNTAELLEQIPDLGQDVKDP 1110
            E +SS   P+               S SE     G +A       L    P L  D  D 
Sbjct: 1144 EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADD 1203

Query: 1111 EDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHIVEHSWFETFIIFMI 1161
            E   ++G         R P C ++       ++    R R  C+ I+ H  F+  ++ +I
Sbjct: 1204 EGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 1162 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAW 1217
             L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 1218 CWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1274
              LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 1275 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1334
             ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEAS 1436

Query: 1335 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1394
                  W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +
Sbjct: 1437 YR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLL 1492

Query: 1395 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE------QKKYYNAM---- 1444
            YF+ F++  +FF LN+F+GV+++NF++ ++    ++    EE      +KK  N M    
Sbjct: 1493 YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDV 1552

Query: 1445 ------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ 1498
                      S+   KP     ++++  +  + T    D+ I  +I LN+VTM +E   Q
Sbjct: 1553 IASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQ 1611

Query: 1499 SPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSD 1556
             P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G  L +
Sbjct: 1612 QPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEE 1671

Query: 1557 I--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1614
            I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ 
Sbjct: 1672 IEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLF 1731

Query: 1615 FIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669
            FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++   L  
Sbjct: 1732 FIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD 1791

Query: 1670 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1729
                CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ 
Sbjct: 1792 ----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1839

Query: 1730 E 1730
            E
Sbjct: 1840 E 1840



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1249
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1250 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1308
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1309 CINQTEGDLP-------------------------------------------------L 1319
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1320 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1371
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1372 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1431
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1432 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  136 bits (342), Expect = 2e-31
 Identities = 197/900 (21%), Positives = 355/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
            G     F ++++P+N  D  VI++  V E +  + G LS LRTFR++R LK +  +P L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  116 bits (291), Expect = 2e-25
 Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 33/324 (10%)

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ-RYLIWECCPLWMSIKQGVKLVVMDP 717
            ++R L    V+ S       S  +C P ++  ++ R L+   C                 
Sbjct: 1543 KRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT--------------SH 1588

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1589 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1648

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1649 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1708

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1709 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1768

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1769 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1828

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1829 KHLEESNKEAKEEAELEAELELEM 1852



 Score =  104 bits (260), Expect = 7e-22
 Identities = 89/370 (24%), Positives = 157/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1543 KRRNLMLDDV 1552



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 65/422 (15%)

Query: 1005 IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDT---DDQEE 1061
            +A    PP   +  +PP    +  +  E    G       +  P   A+S     D    
Sbjct: 610  VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPY 669

Query: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121
                  G  E + ++ P DS SE +  + T  A+          D++DP         RR
Sbjct: 670  CARAGAGEVELADREMP-DSDSE-AVYEFTQDAQ--------HSDLRDPHS-------RR 712

Query: 1122 CPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1180
                  D   +    +WRL   T   IV+  +F   I+  IL+++ ++  E  Y E+ + 
Sbjct: 713  QRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEE 770

Query: 1181 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1240
            +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V       
Sbjct: 771  LTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ----- 825

Query: 1241 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1300
            + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++
Sbjct: 826  QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885

Query: 1301 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1360
            LF  KF    ++ +GD     T+ + K                   NFD++    + + Q
Sbjct: 886  LFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLWAIVTVFQ 918

Query: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420
            + T + W  ++Y      G      W       +YF+  + FG++   NL + ++++ F 
Sbjct: 919  ILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 1421 QQ 1422
             +
Sbjct: 969  AE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1470 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1529
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1530 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1588
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1589 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1644
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1645 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1704
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1705 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1737
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 86/347 (24%), Positives = 139/347 (40%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1578 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1637

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSAL-----RTFRVLRALKT 229
            K++A GF      F +D WN LD ++++++ +   ++   ++A         R++R L+ 
Sbjct: 1638 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1693

Query: 230  ISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1694 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1738

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1739 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1758

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1759 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1816

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1817 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1863



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1476 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1528
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1529 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,441,320
Number of Sequences: 37866
Number of extensions: 3566585
Number of successful extensions: 22996
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 169
Number of HSP's that attempted gapping in prelim test: 17776
Number of HSP's gapped (non-prelim): 2530
length of query: 1962
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1845
effective length of database: 13,817,196
effective search space: 25492726620
effective search space used: 25492726620
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.