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Search of human proteins with 116089292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
(1316 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 2617 0.0
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 1373 0.0
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 1367 0.0
gi|83415184 transmembrane and tetratricopeptide repeat containin... 55 3e-07
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 55 4e-07
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 49 3e-05
gi|34304360 nephrocystin 3 [Homo sapiens] 45 4e-04
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 45 5e-04
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 45 5e-04
gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens] 43 0.002
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 42 0.004
gi|109638749 signal recognition particle 72kDa [Homo sapiens] 42 0.005
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 41 0.007
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 41 0.007
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 41 0.009
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 41 0.009
gi|150418007 RAN binding protein 2 [Homo sapiens] 40 0.011
gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo sapi... 40 0.011
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 40 0.019
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 39 0.025
gi|31621305 leucine-rich PPR motif-containing protein [Homo sapi... 39 0.025
gi|118402596 cell division cycle protein 23 [Homo sapiens] 39 0.025
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 39 0.043
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 39 0.043
gi|221307607 RANBP2-like and GRIP domain containing 3 [Homo sapi... 37 0.096
gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo sapi... 37 0.096
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 37 0.12
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 37 0.12
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 37 0.12
gi|164519122 LGN protein [Homo sapiens] 37 0.12
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 2617 bits (6782), Expect = 0.0
Identities = 1316/1316 (100%), Positives = 1316/1316 (100%)
Query: 1 MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREF 60
MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREF
Sbjct: 1 MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREF 60
Query: 61 EAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWH 120
EAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWH
Sbjct: 61 EAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWH 120
Query: 121 IGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFA 180
IGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFA
Sbjct: 121 IGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFA 180
Query: 181 LLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLL 240
LLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLL
Sbjct: 181 LLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLL 240
Query: 241 QDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCG 300
QDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCG
Sbjct: 241 QDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCG 300
Query: 301 RSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSA 360
RSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSA
Sbjct: 301 RSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSA 360
Query: 361 LVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLN 420
LVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLN
Sbjct: 361 LVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLN 420
Query: 421 DVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISV 480
DVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISV
Sbjct: 421 DVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISV 480
Query: 481 LETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQE 540
LETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQE
Sbjct: 481 LETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQE 540
Query: 541 KVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGA 600
KVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGA
Sbjct: 541 KVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGA 600
Query: 601 STKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN 660
STKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN
Sbjct: 601 STKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN 660
Query: 661 ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMA 720
ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMA
Sbjct: 661 ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMA 720
Query: 721 NPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYE 780
NPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYE
Sbjct: 721 NPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYE 780
Query: 781 AALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKV 840
AALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKV
Sbjct: 781 AALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKV 840
Query: 841 YSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDY 900
YSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDY
Sbjct: 841 YSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDY 900
Query: 901 EKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMAD 960
EKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMAD
Sbjct: 901 EKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMAD 960
Query: 961 LMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAK 1020
LMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAK
Sbjct: 961 LMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAK 1020
Query: 1021 LEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVF 1080
LEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVF
Sbjct: 1021 LEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVF 1080
Query: 1081 ENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVE 1140
ENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVE
Sbjct: 1081 ENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVE 1140
Query: 1141 QALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSW 1200
QALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSW
Sbjct: 1141 QALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSW 1200
Query: 1201 LLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKY 1260
LLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKY
Sbjct: 1201 LLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKY 1260
Query: 1261 SNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP 1316
SNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP
Sbjct: 1261 SNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP 1316
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 1373 bits (3555), Expect = 0.0
Identities = 677/1315 (51%), Positives = 942/1315 (71%), Gaps = 13/1315 (0%)
Query: 10 INYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDV 69
I YY QE+YFHHV A+ G++++ +DPV +F+ AYG L E Q+A+ + E+I++ DV
Sbjct: 12 IIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDV 71
Query: 70 SLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKARE 129
SLCS +ALIYAHK DREAI E + +KE RK ALY+AGLFLW IGRHDKA+E
Sbjct: 72 SLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKE 131
Query: 130 YIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLE 189
YIDRM+KIS G ++ +VL+ W+D+T K KKA++Y E+G+QD D L+GKA
Sbjct: 132 YIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFM 191
Query: 190 MRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEAL 249
M+QNYS ALE VNQI V SFLPA V KM+L LA QDW+QTVE R+L +D N++A
Sbjct: 192 MQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDAC 251
Query: 250 RMQALYYVCREGDI--------EKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGR 301
++ ++ + REG++ +KA+ + NL L+ EP+N L + SR CG
Sbjct: 252 QILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGS 311
Query: 302 SQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSAL 361
Q+IL + + +ER F P ATELGY IL+ +VKEAL WY AM LD+ ++ L
Sbjct: 312 HQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGL 371
Query: 362 VGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLND 421
G I C ++EG L++A+ +LEFL E+Q+S+GKS LI+L A+L +K+K +EE LL +
Sbjct: 372 TGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKE 431
Query: 422 VLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVL 481
++ HFS ++G+PLG +YFEKL+P FL+ I EYL FCP QP PGQ + PLL++ +L
Sbjct: 432 AVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVIL 491
Query: 482 ETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEK 541
VV+ P L+ ++L+A+V+Y SG++E A + LQ CLE +P+ DAHLL+ Q+YL+Q
Sbjct: 492 NPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHLLMCQIYLAQGN 551
Query: 542 VKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGAS 601
+C LEL +S++F+VRD+PLYHLIKA++ K G+ +AIKTL M + LP +K+
Sbjct: 552 FGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKK---E 608
Query: 602 TKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANA 661
K + V S R SI LEL++ RLNGE HEATKV+QD I+EF GT EE R+TIAN
Sbjct: 609 EGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANV 668
Query: 662 DLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMAN 721
DL L++G+++ AL++L+N+ +Q ++EAREKMA+IYL+ +D+ LYI C+RE+ E +
Sbjct: 669 DLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPG 728
Query: 722 PRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEA 781
P + LLLGDA M+ILEPE+A+ Y++A QNP D +LAS++G A +K H Y+ AI YYEA
Sbjct: 729 PHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 788
Query: 782 ALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVY 841
A K +++LC DL +LLLKLK +KAEKVL+ AL H+ V ++ ++M D +C +LLAKVY
Sbjct: 789 AQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVY 848
Query: 842 SKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYE 901
K K I L +A +LQ+R+LKRV +EQP+ +P+QK LAA IC + A+H +A+++Y+
Sbjct: 849 -KSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYD 907
Query: 902 KAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADL 961
KA++ Y++ + TDNK+MLELA+LYL Q D C + CA+LLQ++Q++E A+++MADL
Sbjct: 908 KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 967
Query: 962 MFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKL 1021
MFRKQ +E A+ Q+LE+ PDN++ L +LIDLLRR GKLED+P FF +A+K +SR L
Sbjct: 968 MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPL 1027
Query: 1022 EPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFE 1081
EPGF YC+G+Y W+ G+PN+AL+ NKARKD WGQ+A+Y+M++ICLNPDNE VGGE FE
Sbjct: 1028 EPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFE 1087
Query: 1082 NLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQ 1141
N G N EK+E Q V TAEKLL+E P + QLR+++ C +AT++K+N+E
Sbjct: 1088 N-QGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEA 1146
Query: 1142 ALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWL 1201
AL +F +IA +EK+ +PALL +A AY+ LKQ P+AR QLKR+AK W +AE+ EKSWL
Sbjct: 1147 ALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWL 1206
Query: 1202 LLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYS 1261
LLADIY Q +K+D+A +LL+RC+++N+SC KAYEYMG+IMEKEQ+Y DA NY++AWKYS
Sbjct: 1207 LLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYS 1266
Query: 1262 NRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP 1316
+ NPA+G+KLAFNYLK K++V++I+IC+ VL HP YPKIR++IL+KAR SLRP
Sbjct: 1267 HHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP 1321
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 1367 bits (3537), Expect = 0.0
Identities = 676/1315 (51%), Positives = 941/1315 (71%), Gaps = 14/1315 (1%)
Query: 10 INYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDV 69
I YY QE+YFHHV A+ G++++ +DPV +F+ AYG L E Q+A+ + E+I++ DV
Sbjct: 12 IIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDV 71
Query: 70 SLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKARE 129
SLCS +ALIYAHK DREAI E + +KE RK ALY+AGLFLW IGRHDKA+E
Sbjct: 72 SLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKE 131
Query: 130 YIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLE 189
YIDRM+KIS G ++ +VL+ W+D+T K KKA++Y E+G+QD D L+GKA
Sbjct: 132 YIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFM 191
Query: 190 MRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEAL 249
M+QNYS ALE VNQI V SFLPA V KM+L LA QDW+QTVE R+L +D N++A
Sbjct: 192 MQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDAC 251
Query: 250 RMQALYYVCREGDI--------EKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGR 301
++ ++ + REG++ +KA+ + NL L+ EP+N L + SR CG
Sbjct: 252 QILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGS 311
Query: 302 SQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSAL 361
Q+IL + + +ER F P ATELGY IL+ +VKEAL WY AM LD+ ++ L
Sbjct: 312 HQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGL 371
Query: 362 VGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLND 421
G I C ++EG L++A+ +LEFL E+Q+S+GKS LI+L A+L +K+K +EE LL +
Sbjct: 372 TGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKE 431
Query: 422 VLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVL 481
++ HFS ++G+PLG +YFEKL+P FL+ I EYL FCP QP PGQ + PLL++ +L
Sbjct: 432 AVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVIL 491
Query: 482 ETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEK 541
VV+ P L+ ++L+A+V+Y S ++E A + LQ CLE +P+ DAHLL+ Q+YL+Q
Sbjct: 492 NPVVKAAPALIDPLYLMAQVRYYS-ELENAQSILQRCLELDPASVDAHLLMCQIYLAQGN 550
Query: 542 VKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGAS 601
+C LEL +S++F+VRD+PLYHLIKA++ K G+ +AIKTL M + LP +K+
Sbjct: 551 FGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKK---E 607
Query: 602 TKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANA 661
K + V S R SI LEL++ RLNGE HEATKV+QD I+EF GT EE R+TIAN
Sbjct: 608 EGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANV 667
Query: 662 DLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMAN 721
DL L++G+++ AL++L+N+ +Q ++EAREKMA+IYL+ +D+ LYI C+RE+ E +
Sbjct: 668 DLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPG 727
Query: 722 PRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEA 781
P + LLLGDA M+ILEPE+A+ Y++A QNP D +LAS++G A +K H Y+ AI YYEA
Sbjct: 728 PHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEA 787
Query: 782 ALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVY 841
A K +++LC DL +LLLKLK +KAEKVL+ AL H+ V ++ ++M D +C +LLAKVY
Sbjct: 788 AQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVY 847
Query: 842 SKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYE 901
K K I L +A +LQ+R+LKRV +EQP+ +P+QK LAA IC + A+H +A+++Y+
Sbjct: 848 -KSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYD 906
Query: 902 KAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADL 961
KA++ Y++ + TDNK+MLELA+LYL Q D C + CA+LLQ++Q++E A+++MADL
Sbjct: 907 KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 966
Query: 962 MFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKL 1021
MFRKQ +E A+ Q+LE+ PDN++ L +LIDLLRR GKLED+P FF +A+K +SR L
Sbjct: 967 MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPL 1026
Query: 1022 EPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFE 1081
EPGF YC+G+Y W+ G+PN+AL+ NKARKD WGQ+A+Y+M++ICLNPDNE VGGE FE
Sbjct: 1027 EPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFE 1086
Query: 1082 NLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQ 1141
N G N EK+E Q V TAEKLL+E P + QLR+++ C +AT++K+N+E
Sbjct: 1087 N-QGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEA 1145
Query: 1142 ALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWL 1201
AL +F +IA +EK+ +PALL +A AY+ LKQ P+AR QLKR+AK W +AE+ EKSWL
Sbjct: 1146 ALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWL 1205
Query: 1202 LLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYS 1261
LLADIY Q +K+D+A +LL+RC+++N+SC KAYEYMG+IMEKEQ+Y DA NY++AWKYS
Sbjct: 1206 LLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYS 1265
Query: 1262 NRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP 1316
+ NPA+G+KLAFNYLK K++V++I+IC+ VL HP YPKIR++IL+KAR SLRP
Sbjct: 1266 HHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP 1320
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 55.5 bits (132), Expect = 3e-07
Identities = 71/319 (22%), Positives = 131/319 (41%), Gaps = 23/319 (7%)
Query: 509 EAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVK----LCSQSLELCLSYDFKVRDYPL 564
E A L+ +++ P +ADA+ LA + QE+ K + ++ C +Y +
Sbjct: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV 516
Query: 565 YHLIKAQSQKKMGEIADAIK---TLHMAMSLPG--MKRIGASTKSKD-RKTEVDTSHRLS 618
+ + +K + AIK + H+AM G + +G ++ +++ K + +H+
Sbjct: 517 FLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAE 576
Query: 619 IFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQ 678
I L ++ G EA ++ Q+A + E+R +A A + G + A +
Sbjct: 577 ILSPLGALYYNTGRYEEALQIYQEAA-ALQPSQRELR--LALAQVLAVMGQTKEAEKMTN 633
Query: 679 NVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPR----SFLLLGDAYMN 734
++ +E+ +E ++ IY K + + + +P+ F G+
Sbjct: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693
Query: 735 ILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYD 794
++A +Y A+ NP MG Y A YYE AL+ + L
Sbjct: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKL--- 750
Query: 795 LAELLLKLKWYDKAEKVLQ 813
L E L KL D+ EK LQ
Sbjct: 751 LKENLAKL---DRLEKRLQ 766
Score = 54.7 bits (130), Expect = 6e-07
Identities = 71/351 (20%), Positives = 140/351 (39%), Gaps = 37/351 (10%)
Query: 662 DLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKM---LYITCFREIAER 718
+L +Q E A+++L++ P F +A +A + + + K +Y T + +
Sbjct: 448 NLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDS 507
Query: 719 MANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITY 778
++ G ++ PE+A+ Y+QA+ +P +G+ SMA +
Sbjct: 508 SDLHNNY---GVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEW 564
Query: 779 YEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLA 838
Y+ AL+ K + L L Y++A ++ Q A A +P ++ LA
Sbjct: 565 YKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQP--------SQRELRLALA 616
Query: 839 KVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQR 898
+V + M + +A ++ + E+ + + L+A Q
Sbjct: 617 QVLAVMGQTKEA-----------EKMTNHIVSEETGCLECYRLLSAIYS--------KQE 657
Query: 899 DYEKAIKFYREALVHCETDNKIMLEL----ARLYLAQDDPDSCLRQCALLLQSDQDNEAA 954
+++KA+ +AL D K++ EL Q+ D + +Q + D A
Sbjct: 658 NHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717
Query: 955 TMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDV 1005
M M + K Y A + ++ L+ PD+ + L L R +L++V
Sbjct: 718 WMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEV 768
Score = 31.6 bits (70), Expect = 5.2
Identities = 44/196 (22%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 236 QRLLLQDSQNVEALRMQALYYVCREGDI-EKASTKLENLGNTLDAMEPQNAQLFYNITLA 294
Q + L S +V + + LY E + E+ + + + + + P A L+YN
Sbjct: 533 QAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGA-LYYNT--- 588
Query: 295 FSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLD 354
GR + LQ + + A +L P Q E L + + G+ KEA K +
Sbjct: 589 -----GRYEEALQ----IYQEAAALQPSQRELRLALAQVLAVMGQTKEAEK-------MT 632
Query: 355 ETSVSALVGFIQC----QLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNK 410
VS G ++C I + ++ D+ L+ +++ Q K ++I + K N+
Sbjct: 633 NHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVI--SELFFTKGNQ 690
Query: 411 RQEEVINLLNDVLDTH 426
+E+ NLL+ +++
Sbjct: 691 LREQ--NLLDKAFESY 704
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 55.1 bits (131), Expect = 4e-07
Identities = 124/659 (18%), Positives = 266/659 (40%), Gaps = 93/659 (14%)
Query: 686 YFIEA--REKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPE---E 740
Y+++ +EK D ++KD + T +A+++ LLG A +LE + +
Sbjct: 92 YYVQQARKEKNKD----NKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQ 147
Query: 741 AIVAYEQALNQNPKDGTLASKMGKALIKTH--NYSMAITYYEAALKT--GQKNYLCYDLA 796
A + LNQ+P + + + +GKA I + +Y A+ YY+ AL+T G + +
Sbjct: 148 ADAQFHFVLNQSPNN--IPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMG 205
Query: 797 ELLLKLKWYDKAEKVLQHALAHEP----------VNELSALMEDG--RCQVLLAKVYS-- 842
+KL +KA AL V EL+ D LL++ Y+
Sbjct: 206 HCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTID 265
Query: 843 -----KMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQ 897
+ L + + ++Q L + +A + AE C ++A+ Q
Sbjct: 266 PSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEA------MQAESCYQLARSFHVQ 319
Query: 898 RDYEKAIKFYREALVHCETDNKI-MLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATM 956
DY++A ++Y +A + + L ++Y+ + D ++ + +L++ +N
Sbjct: 320 EDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMK 379
Query: 957 MMADLMFRKQDYEQ---AVFHLQQLLERKPDN---YMTLSRLIDLLRRCGKLEDVPRFFS 1010
++ L +D E+ A HL+++ E+ PD+ ++ L+++++ G L
Sbjct: 380 ILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATR 439
Query: 1011 MAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHF----NKARKDRDWGQNALYNMIEI 1066
+ +++ +A + P G + G +A ++F ++A+ + + ++ YN I +
Sbjct: 440 ILQEK-VQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEH-YYNAISV 497
Query: 1067 CLNPDNETVGGEVFENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIME 1126
+L E A + + +L+E P V +++L M
Sbjct: 498 ---------------TTSYNLARLYEAMCEFHEAEKLYKNILRE-HPNYVDCYLRLGAM- 540
Query: 1127 NYCLMATKQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKM 1186
+ K N +A + F E ++H A + ++ ++ + + +RI K
Sbjct: 541 ------ARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQ 594
Query: 1187 NWNAIDAEEFEKSWLLLADIYIQS------------AKYDMAEDLLKRCLRHNRSCCKAY 1234
D S L L ++++Q+ D A + K+ LR++ A
Sbjct: 595 PSTQSDT----YSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAA 650
Query: 1235 EYMGYIMEKEQAYTDAALNYEMAWKYSNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVL 1293
+G ++ + + +A + + + V LA Y++ K+Y+ ++ + L
Sbjct: 651 NGIGAVLAHKGYFREARDVFAQV-REATADISDVWLNLAHIYVEQKQYISAVQMYENCL 708
Score = 31.2 bits (69), Expect = 6.8
Identities = 57/224 (25%), Positives = 89/224 (39%), Gaps = 30/224 (13%)
Query: 173 QDGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPA---------FVKKMKLQL 223
Q N+ ALLGKA +++Y GAL + + P PA FVK KL+
Sbjct: 158 QSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPG-CPAEVRLGMGHCFVKLNKLEK 216
Query: 224 ALQDWDQTVETAQRLLLQDSQNVEAL-RMQALYYVCREGDIEKASTKLENLGNTLDAMEP 282
A + + +E +S+ V AL + L +E D K +L + T+D P
Sbjct: 217 ARLAFSRALEL-------NSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTID---P 266
Query: 283 QNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAF---SLNPQQSEFATELGYQMILQGR 339
N + ++ F S K+Q L AF + Q+E +L +Q
Sbjct: 267 SNPMVLNHLANHFFFKKDYS-----KVQHLALHAFHNTEVEAMQAESCYQLARSFHVQED 321
Query: 340 VKEALKWYKTAMTLDETS-VSALVGFIQCQLIEGQLQDADQQLE 382
+A ++Y A +S V G Q + G ++A Q E
Sbjct: 322 YDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFE 365
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 48.9 bits (115), Expect = 3e-05
Identities = 91/422 (21%), Positives = 165/422 (39%), Gaps = 66/422 (15%)
Query: 623 LIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQNVTA 682
LI +H + + V+++ + E G E A + +G+I+ +L + Q
Sbjct: 38 LIHLHYIRKDYEACKAVIKEQLQETQGLCEYA--IYVQALIFRLEGNIQESLELFQTCAV 95
Query: 683 EQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLL---LGDAYMNILEPE 739
P + +++A K K I + E A+ N + + + LG Y+ + +
Sbjct: 96 LSPQSADNLKQVARSLFLLGKHKAA-IEVYNEAAK--LNQKDWEISHNLGVCYIYLKQFN 152
Query: 740 EAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNY-LCYDLAEL 798
+A ALN N D T +GK + + AI Y+ A++ +N L L L
Sbjct: 153 KAQDQLHNALNLNRHDLTYIM-LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLL 211
Query: 799 LLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQAR 858
L+L Y KA + L +AL ++P N A++ G S M+ GD AL + R
Sbjct: 212 YLQLGIYQKAFEHLGNALTYDPTN-YKAILAAG----------SMMQTHGDFDVALTKYR 260
Query: 859 ELQARVLKRVQMEQPDAVP-----------AQKHLAAEICAEIAKH-------------- 893
+ V P++ P +K++AA C + A +
Sbjct: 261 VVACAV--------PESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGL 312
Query: 894 -SVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNE 952
+ + Y A F A+ ++ + LA +D ++ R A + D+ N
Sbjct: 313 VHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNP 372
Query: 953 AATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMA 1012
+ A L++ + + + A+ Q+ +E+K + LL+ LE MA
Sbjct: 373 LVNLNYAVLLYNQGEKKNALAQYQE-MEKK----------VSLLKDNSSLEFDSEMVEMA 421
Query: 1013 EK 1014
+K
Sbjct: 422 QK 423
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 45.4 bits (106), Expect = 4e-04
Identities = 63/256 (24%), Positives = 112/256 (43%), Gaps = 26/256 (10%)
Query: 671 ERALSILQNVT-AEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLG 729
++AL I +N A+ PY E +A +Y K K + FR+ + ++ + ++ G
Sbjct: 1009 KQALEISENAYGADHPYTARELEALATLYQKQNKYEQA--EHFRKKSFKI-HQKAIKKKG 1065
Query: 730 DAYMNILEPEEAIVAYEQALNQN-PKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQK 788
+ Y L A+ E L ++ P + +++G +N A + + +L+ ++
Sbjct: 1066 NLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER 1125
Query: 789 ---------NYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVL--- 836
+LA L + K YDKAE++ + AL AL D
Sbjct: 1126 VLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRR----RALAPDHPSLAYTVK 1181
Query: 837 -LAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSV 895
LA +Y KM KL A+ + A E++ K + P A +LA + +++ KH
Sbjct: 1182 HLAILYKKMGKLDKAVPLYELAVEIRQ---KSFGPKHPSVATALVNLAV-LYSQMKKHVE 1237
Query: 896 AQRDYEKAIKFYREAL 911
A YE+A+K Y ++L
Sbjct: 1238 ALPLYERALKIYEDSL 1253
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 45.1 bits (105), Expect = 5e-04
Identities = 41/171 (23%), Positives = 77/171 (45%), Gaps = 16/171 (9%)
Query: 255 YYVCREGDIEKASTKLENLGNTLDAMEPQNAQ--LFYNITLAFSRTCGRSQLILQKIQTL 312
Y + REG +E +ENLG L + Q+A+ + +S+ R+ + K
Sbjct: 313 YLLAREGRLED----VENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAK---- 364
Query: 313 LERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEG 372
A LN + G + GRV+EA+ ++ A+ L + G I+C L
Sbjct: 365 ---AIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASN 421
Query: 373 QLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVL 423
+++A + N + +++G +A+ + L A + ++ QE+ LL+ L
Sbjct: 422 SIREA---MVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKAL 469
Score = 32.7 bits (73), Expect = 2.4
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 685 PYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVA 744
P IE + KMA+ Y ++DK I I R P+ ++L + Y + ++ +
Sbjct: 133 PSEIEVKYKMAECYTMLKQDKDA-IAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTS 191
Query: 745 YEQALNQNP 753
Y++ L Q P
Sbjct: 192 YKEVLRQCP 200
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 45.1 bits (105), Expect = 5e-04
Identities = 41/171 (23%), Positives = 77/171 (45%), Gaps = 16/171 (9%)
Query: 255 YYVCREGDIEKASTKLENLGNTLDAMEPQNAQ--LFYNITLAFSRTCGRSQLILQKIQTL 312
Y + REG +E +ENLG L + Q+A+ + +S+ R+ + K
Sbjct: 313 YLLAREGRLED----VENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAK---- 364
Query: 313 LERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEG 372
A LN + G + GRV+EA+ ++ A+ L + G I+C L
Sbjct: 365 ---AIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASN 421
Query: 373 QLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVL 423
+++A + N + +++G +A+ + L A + ++ QE+ LL+ L
Sbjct: 422 SIREA---MVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKAL 469
Score = 34.3 bits (77), Expect = 0.81
Identities = 34/143 (23%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 616 RLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALS 675
RL + LI+ + + EA V+ + +++ G + + +A L E+A +
Sbjct: 406 RLDCYEGLIECYLASNSIREAM-VMANNVYKTLGANAQTLTLLATVCLEDPVTQ-EKAKT 463
Query: 676 ILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLL---LGDAY 732
+L ++P +I+A K A++ + +K Y + +AN +L LGD
Sbjct: 464 LLDKALTQRPDYIKAVVKKAELLSREQK----YEDGIALLRNALANQSDCVLHRILGDFL 519
Query: 733 MNILEPEEAIVAYEQALNQNPKD 755
+ + E +EA+ Y AL+ +P D
Sbjct: 520 VAVNEYQEAMDQYSIALSLDPND 542
Score = 32.7 bits (73), Expect = 2.4
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 685 PYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVA 744
P IE + KMA+ Y ++DK I I R P+ ++L + Y + ++ +
Sbjct: 133 PSEIEVKYKMAECYTMLKQDKDA-IAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTS 191
Query: 745 YEQALNQNP 753
Y++ L Q P
Sbjct: 192 YKEVLRQCP 200
>gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens]
Length = 297
Score = 43.1 bits (100), Expect = 0.002
Identities = 40/197 (20%), Positives = 79/197 (40%), Gaps = 32/197 (16%)
Query: 896 AQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAAT 955
A Y+ AI+ Y L T+ + AQ +R+ L+ ++ A
Sbjct: 99 AMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAW 158
Query: 956 MMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVP---RFFSMA 1012
+A+L + DY +A F L++L+ P N++ + ++ G LE++ ++F+ A
Sbjct: 159 HELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQA 218
Query: 1013 EKRNSRAKLEPGFQYCKGLYL------------------------WYTGEPNDALRHFNK 1048
K N+R + GLY+ W + N A + +
Sbjct: 219 LKLNNR-----NMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGR 273
Query: 1049 ARKDRDWGQNALYNMIE 1065
++K+ + A+ +M+E
Sbjct: 274 SKKETKYSLKAVEDMLE 290
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]
Length = 504
Score = 42.0 bits (97), Expect = 0.004
Identities = 73/414 (17%), Positives = 155/414 (37%), Gaps = 61/414 (14%)
Query: 761 KMGKALIKTHNYSMAITYYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEP 820
++GK L+ + A++ + AA+ NY+ Y + KA +
Sbjct: 42 ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101
Query: 821 VNELSALMEDGRC---QVLLAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVP 877
++ +A ++ G Q L + +K+ + + + +E Q++++K +M++
Sbjct: 102 MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQR----- 156
Query: 878 AQKHLAAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSC 937
A ++ DY AI F + L C D ++ A ++ + +P
Sbjct: 157 ---------LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKA 207
Query: 938 LRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPD------NYMTLSR 991
+ + DN A ++ L ++ D+E ++ +++ L+ D +Y + +
Sbjct: 208 ISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKK 267
Query: 992 LIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRH-FNKAR 1050
L L+ +L R+ K S K EP YT + + H F+K
Sbjct: 268 LNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAE-------YTVRSKERICHCFSKDE 320
Query: 1051 KDRDWGQNALYNMIEIC-----LNPDNET---------VGGEVFENLDGDLGNSTEKQES 1096
K I +C + PDN + E+++ D + E E+
Sbjct: 321 KP--------VEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNEN 372
Query: 1097 VQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQALNTFTEIA 1150
Q EK + LK Q + + Y ++ K+ + ++ + + ++A
Sbjct: 373 DQQIREGLEKAQRLLK--------QSQKRDYYKILGVKRNAKKQEIIKAYRKLA 418
Score = 42.0 bits (97), Expect = 0.004
Identities = 65/280 (23%), Positives = 111/280 (39%), Gaps = 35/280 (12%)
Query: 506 GDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFK------- 558
G ++ A ++ + L+ NPS + +Q+ S E +L SQ+L S D+
Sbjct: 119 GKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLD 178
Query: 559 ------VRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDRKTEVD 612
V D L L +A+ K GE AI L A++K K+ TE
Sbjct: 179 KILEVCVWDAELREL-RAECFIKEGEPRKAISDLK------------AASKLKNDNTEA- 224
Query: 613 TSHRLSIFLELIDVHRLN-GEQHEATKVLQDAIHEFSGTSEEVRVT--IANADLALAQGD 669
+++S + H L+ E E K+ QD F+ + ++ I +A+ + G
Sbjct: 225 -FYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGR 283
Query: 670 IERALSILQNVTAEQP----YFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSF 725
A S ++V +P Y + ++E++ + K K C + N +
Sbjct: 284 YTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNAL 343
Query: 726 LLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKA 765
+AY+ +EAI YE A N D + + KA
Sbjct: 344 KDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKA 383
>gi|109638749 signal recognition particle 72kDa [Homo sapiens]
Length = 671
Score = 41.6 bits (96), Expect = 0.005
Identities = 86/371 (23%), Positives = 148/371 (39%), Gaps = 73/371 (19%)
Query: 138 SDGSKQGHVLKAWLDITR-GKEPYTKKALKYFEEGLQ-DGNDTFALLGKAQCLEMRQNYS 195
S GS V W ++ R G+ +ALK + LQ + +D AL K CL ++
Sbjct: 3 SGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFK 62
Query: 196 GALETVNQ----IIVNFPSFLPAFVKKM--KLQLALQDWDQTVETAQRLLLQDSQNVEAL 249
AL +N + N SF A+ + +++ AL+ T+E+A Q + ++ L
Sbjct: 63 EALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALK----TIESAN----QQTDKLKEL 114
Query: 250 RMQALYYVCREGDI----------------EKASTKLENL---GNTLDAMEPQNA----- 285
Q LY + R + E+ T L + + + + P+N
Sbjct: 115 YGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEG 174
Query: 286 --QLFYNITLAFSRTCGRSQL-----ILQKIQTLLERAFSLNPQ------QSEFAT---E 329
+L YN A G+ QL ILQK + L R+ S + Q+E A +
Sbjct: 175 THELCYNTACAL---IGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQ 231
Query: 330 LGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEGQLQDADQQLEFLNEIQQ 389
+ Y + LQGR +EAL+ Y + L T V G L + +N+ Q
Sbjct: 232 MAYILQLQGRTEEALQLYNQIIKLKPTDV-------------GLLAVIANNIITINKDQN 278
Query: 390 SIGKSAELIYLHAV-LAMKKNKRQEEVINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFL 448
++ +A + K +K+Q + I +L + +Q E + +P+ L
Sbjct: 279 VFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHL 338
Query: 449 LEIVMEYLSFC 459
L ++++ C
Sbjct: 339 LPVLIQAAQLC 349
Score = 34.7 bits (78), Expect = 0.62
Identities = 43/171 (25%), Positives = 80/171 (46%), Gaps = 25/171 (14%)
Query: 596 KRIGASTKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQH-EATKVLQDAIHEFSGTSEEV 654
++I AS +S+ + H L + ++ + R +QH +A ++LQ+ + + E+
Sbjct: 324 RKISASLQSQSPE------HLLPVLIQAAQLCR--EKQHTKAIELLQEFSDQHPENAAEI 375
Query: 655 RVTIANADLALAQGDIERALSILQNVTA--EQPYFIEAREKMADIYLKHRKDKMLYITCF 712
++T+A L ++QG+I +A IL+++ +P + A M H +D I F
Sbjct: 376 KLTMAQ--LKISQGNISKACLILRSIEELKHKPGMVSALVTM----YSHEEDIDSAIEVF 429
Query: 713 REIAERMAN-----PRSFLLLGDAYMNILE---PEEAIVAYEQALNQNPKD 755
+ + N P L+ +A L+ +EAI +Q QNPKD
Sbjct: 430 TQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD 480
Score = 32.0 bits (71), Expect = 4.0
Identities = 44/203 (21%), Positives = 85/203 (41%), Gaps = 17/203 (8%)
Query: 791 LCYDLAELLLKLKWYDKAEKVLQHA--LAHEPVNELSALMEDGRCQVLLAKVYSKMEKLG 848
LCY+ A L+ ++A K+LQ A L ++E + E+ Q LA ++ +M +
Sbjct: 178 LCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDP-QAELAIIHGQMAYIL 236
Query: 849 DAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQR--DYEKAIKF 906
++A +L +++K P L A I I + Q D +K +K
Sbjct: 237 QLQGRTEEALQLYNQIIK--------LKPTDVGLLAVIANNIITINKDQNVFDSKKKVKL 288
Query: 907 YREALVHCETDNK----IMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLM 962
V + K I A L + + + C + A L ++ ++ A +
Sbjct: 289 TNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQL 348
Query: 963 FRKQDYEQAVFHLQQLLERKPDN 985
R++ + +A+ LQ+ ++ P+N
Sbjct: 349 CREKQHTKAIELLQEFSDQHPEN 371
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 41.2 bits (95), Expect = 0.007
Identities = 45/206 (21%), Positives = 88/206 (42%), Gaps = 6/206 (2%)
Query: 218 KMKLQLALQDWDQTVETAQRLLLQDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTL 277
K + ALQD Q + L L+ ++ + L M+ D++K S LE++ L
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 278 DAMEPQNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQ 337
E + L + T + + + +IQT + + ++ TEL
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 338 GRVKEALKWYKTAMTLDETSVSALVGFIQ--CQLIEGQLQ-DADQQLEFLNEIQQSIGKS 394
+V ++LK K+ + A + ++ C+ ++ QLQ + L+ E+++S+ K
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 395 AELIYLHAVLAMKKNKRQEEVINLLN 420
E + L ++ N QE++I N
Sbjct: 923 KEASH---QLKLELNSMQEQLIQAQN 945
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 41.2 bits (95), Expect = 0.007
Identities = 78/374 (20%), Positives = 142/374 (37%), Gaps = 59/374 (15%)
Query: 488 VPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQ 547
+PGLL L + K G + A ++ L P A+ H L A ++ +++ +
Sbjct: 385 IPGLLVLKSLAYRNK---GSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEK 441
Query: 548 SLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDR 607
+ L D +V +Y H + MGE KT + L +
Sbjct: 442 CFQRALEKDTEVAEY---HYQLGLTYWFMGEETRKDKTKALTHFL--------------K 484
Query: 608 KTEVDTSHRLSIFLELIDVHR-LNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALA 666
+DT + +F L +R + G+++ A + A E T E A DL++
Sbjct: 485 AARLDT-YMGKVFCYLGHYYRDVVGDKNRARGCYRKAF-ELDDTDAESGA--AAVDLSVE 540
Query: 667 QGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFL 726
D+E AL+IL VT + A ++L
Sbjct: 541 LEDMEMALAILTTVTQK--------------------------------ASAGTAKWAWL 568
Query: 727 LLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTG 786
G Y+ + +A+ + AL +PKD +G+A + Y+ A+ + A +
Sbjct: 569 RRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELN 628
Query: 787 QKN-YLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKME 845
++ Y + +A + L Y +A Q + + + + AL G C +++AK
Sbjct: 629 PESIYSVFKVAAIQQILGKYKEAVAQYQ-MIIKKKEDYVPALKGLGECHLMMAKAALVDY 687
Query: 846 KLGDAITALQQARE 859
G A+ +++A E
Sbjct: 688 LDGKAVDYIEKALE 701
Score = 31.2 bits (69), Expect = 6.8
Identities = 59/304 (19%), Positives = 124/304 (40%), Gaps = 24/304 (7%)
Query: 693 KMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQN 752
K A +++++ K C + + N +++ +G A + +P++A AY++A
Sbjct: 11 KSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELE 70
Query: 753 PKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVL 812
P D LA + L + +N+ A + DL E + K KW D +K++
Sbjct: 71 P-DQLLAWQGLANLYEKYNHINAKDDLPGVYQK------LLDLYESVDKQKWCDVCKKLV 123
Query: 813 QHALAHEPVNE--------LSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARV 864
+ E + E G L +++ K+ + A + Q E Q +
Sbjct: 124 DLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQF-LAESTEDQNNETQQLL 182
Query: 865 LKRVQ--MEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKA-IKFYREALVHCETDNKIM 921
+ + D +P++ H ++ S+++ +E A +K E +++ +
Sbjct: 183 FTAFENALGLSDKIPSEDH---QVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYP 239
Query: 922 LELARLYLAQDD--PDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLL 979
LE+ L+L + D + C L++ D + + + + + YE AV +L + L
Sbjct: 240 LEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGL 299
Query: 980 ERKP 983
+ P
Sbjct: 300 KESP 303
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 9/138 (6%)
Query: 724 SFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAAL 783
++ LLG ++ E ++A+ + A+ NP+ +G K +S+A +++ AL
Sbjct: 609 AYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKAL 668
Query: 784 KTG-QKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYS 842
Q + L + + LK +KA L A+ +P N L C+ A V
Sbjct: 669 DINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL--------CKFHRASVLF 720
Query: 843 KMEKLGDAITALQQAREL 860
EK A+ L++ +++
Sbjct: 721 ANEKYKSALQELEELKQI 738
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 9/138 (6%)
Query: 724 SFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAAL 783
++ LLG ++ E ++A+ + A+ NP+ +G K +S+A +++ AL
Sbjct: 603 AYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKAL 662
Query: 784 KTG-QKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYS 842
Q + L + + LK +KA L A+ +P N L C+ A V
Sbjct: 663 DINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL--------CKFHRASVLF 714
Query: 843 KMEKLGDAITALQQAREL 860
EK A+ L++ +++
Sbjct: 715 ANEKYKSALQELEELKQI 732
>gi|150418007 RAN binding protein 2 [Homo sapiens]
Length = 3224
Score = 40.4 bits (93), Expect = 0.011
Identities = 44/195 (22%), Positives = 80/195 (41%), Gaps = 10/195 (5%)
Query: 666 AQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKML--YITCFREIAERMANPR 723
++ D+ER ++ +Q T A +Y + ++ + YI + + ER +P+
Sbjct: 4 SKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQER--DPK 61
Query: 724 SFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYY-EAA 782
+ LG Y ++A+ Y +++ NP L K+ + L K Y+ E A
Sbjct: 62 AHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLERA 121
Query: 783 LKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYS 842
K + Y L E LL + D K+ + EL +D + L +VY
Sbjct: 122 AKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQS-----ELYVRPDDVHVNIRLVEVYR 176
Query: 843 KMEKLGDAITALQQA 857
++L DA+ +A
Sbjct: 177 STKRLKDAVAHCHEA 191
>gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo
sapiens]
Length = 1756
Score = 40.4 bits (93), Expect = 0.011
Identities = 38/151 (25%), Positives = 62/151 (41%), Gaps = 8/151 (5%)
Query: 708 YITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALI 767
Y+ + + ER +PR+ LG Y E+A+ Y ++L NP L K+ + L
Sbjct: 47 YVCTYLSVQER--DPRAHRFLGLLYELEENTEKAVECYRRSLELNPPQKDLVLKIAELLC 104
Query: 768 KTHNYSMAITYY-EAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSA 826
K Y+ E A K + Y L E LL + D K+ +EL
Sbjct: 105 KNDVTDGRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWI-----QSELYV 159
Query: 827 LMEDGRCQVLLAKVYSKMEKLGDAITALQQA 857
+D + L ++Y ++L DA+ +A
Sbjct: 160 RPDDVHMNIRLVELYRSNKRLKDAVARCHEA 190
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 39.7 bits (91), Expect = 0.019
Identities = 39/193 (20%), Positives = 81/193 (41%), Gaps = 11/193 (5%)
Query: 802 LKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKME--------KLGDAITA 853
LK D+ ++Q + +PV + A++E + +L+ + + E + TA
Sbjct: 13 LKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTA 72
Query: 854 LQQARELQARV-LKRVQMEQPDAVPAQKH--LAAEICAEIAKHSVAQRDYEKAIKFYREA 910
++ A E+ + L V+ + + ++ + A+ E + A+ +YE AI Y E
Sbjct: 73 MKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEG 132
Query: 911 LVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQ 970
L + + A+ Y+ +D + L C L+ D+ A M ++Y
Sbjct: 133 LEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSV 192
Query: 971 AVFHLQQLLERKP 983
+ +++LE P
Sbjct: 193 SRECYKKILEINP 205
Score = 33.1 bits (74), Expect = 1.8
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 731 AYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNY 790
AYM + + E+A+V E AL + K MGKA + NYS++ Y+ L+ K
Sbjct: 149 AYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPK-- 206
Query: 791 LCYDLAELLLKLKWYDKAEKVLQHALAHE 819
L + L ++ +KA+ LQ AHE
Sbjct: 207 LQTQVKGYLNQVDLQEKAD--LQEKEAHE 233
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 39.3 bits (90), Expect = 0.025
Identities = 51/245 (20%), Positives = 95/245 (38%), Gaps = 13/245 (5%)
Query: 746 EQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCY-DLAELLLKLKW 804
E+ L +N K ++G K ++ A+ +Y+ A + N + A + +
Sbjct: 215 EEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGD 274
Query: 805 YDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQ--ARELQA 862
Y+K ++ + A+ N + + + Y K EK DAI + A
Sbjct: 275 YNKCRELCEKAIEVGRENR-EDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTP 333
Query: 863 RVLKRVQMEQPDAVPAQKHLAAEICAEIA-------KHSVAQRDYEKAIKFYREALVHCE 915
VLK+ Q Q + + ++ A I ++A + DY +A+K Y EA+
Sbjct: 334 DVLKKCQ--QAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNP 391
Query: 916 TDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHL 975
D K+ A Y + L+ C +Q + A + +DY +A+
Sbjct: 392 KDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVY 451
Query: 976 QQLLE 980
Q+ L+
Sbjct: 452 QKALD 456
Score = 38.9 bits (89), Expect = 0.033
Identities = 35/171 (20%), Positives = 74/171 (43%), Gaps = 20/171 (11%)
Query: 889 EIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSD 948
E+ + ++D++ A+K Y +A T+ + A +Y + D + C C ++
Sbjct: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289
Query: 949 QDNE-------AATMMMADLMFRKQDYEQAV-FHLQQLLERKPDNYMTLSRLIDLLRRCG 1000
++N A + + F+++ Y+ A+ F+ + L E R D+L++C
Sbjct: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEH---------RTPDVLKKCQ 340
Query: 1001 KLEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHFNKARK 1051
+ E + + N LE + KG + G+ A++H+ +A K
Sbjct: 341 QAEKILKEQERLAYINPDLALE---EKNKGNECFQKGDYPQAMKHYTEAIK 388
Score = 34.7 bits (78), Expect = 0.62
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 26/109 (23%)
Query: 884 AEICAEIAKHSVAQRDYEKAIKFYREALVH---------CETDNKIMLELARLYLAQDDP 934
A+ A I + Y+ AI FY ++L C+ KI+ E RL A +P
Sbjct: 300 AKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERL--AYINP 357
Query: 935 DSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKP 983
D L + ++ NE F+K DY QA+ H + ++R P
Sbjct: 358 DLALEE------KNKGNEC---------FQKGDYPQAMKHYTEAIKRNP 391
Score = 32.7 bits (73), Expect = 2.4
Identities = 23/99 (23%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 155 RGKEPYTK----KALKYFEEGLQ-DGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFP 209
+G E + K +A+K++ E ++ + D +A C + AL+ + I P
Sbjct: 366 KGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEP 425
Query: 210 SFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEA 248
+F+ + +K A++D+ + ++ Q+ L DS EA
Sbjct: 426 TFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
Score = 32.0 bits (71), Expect = 4.0
Identities = 39/157 (24%), Positives = 66/157 (42%), Gaps = 12/157 (7%)
Query: 740 EAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALK---TGQKNYLCYDLA 796
+A+ Y +A+ +NPKD L S K + +A+ E ++ T K Y A
Sbjct: 378 QAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYT--RKA 435
Query: 797 ELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDG--RCQVLLAKVYSKMEKLGDAITAL 854
L +K Y KA V Q AL + + +A DG RC + + E + A
Sbjct: 436 AALEAMKDYTKAMDVYQKALDLDSSCKEAA---DGYQRCMMAQYNRHDSPEDVKRRAMAD 492
Query: 855 QQARELQARVLKRVQME--QPDAVPAQKHLAAEICAE 889
+ +++ + R+ +E Q D +HL + A+
Sbjct: 493 PEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQ 529
>gi|31621305 leucine-rich PPR motif-containing protein [Homo sapiens]
Length = 1394
Score = 39.3 bits (90), Expect = 0.025
Identities = 34/144 (23%), Positives = 67/144 (46%), Gaps = 4/144 (2%)
Query: 315 RAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDET-SVSALVGFIQCQLIEGQ 373
+ F+LN + + L + + +KEA+ KT + +T S A+ IQ ++G
Sbjct: 1098 KGFTLNDAAN---SRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGD 1154
Query: 374 LQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGL 433
+++ + + LN ++ SIG S + + LA KN + I + ++L + +E
Sbjct: 1155 VENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQ 1214
Query: 434 PLGIQYFEKLNPDFLLEIVMEYLS 457
G+ Y + + LE +E +S
Sbjct: 1215 YFGLAYLFRKVIEEQLEPAVEKIS 1238
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 39.3 bits (90), Expect = 0.025
Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 56/238 (23%)
Query: 669 DIERALSILQNVTAEQPYFIEAREKMADI-YLKHRKDKMLYI-------------TC--- 711
DI++ALSI + + PY IE + +++ Y++ K ++ Y+ TC
Sbjct: 278 DIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVI 337
Query: 712 -----FREIAERMA---------NPR---SFLLLGDAYMNILEPEEAIVAYEQALNQNPK 754
R E+ A NPR ++ L+G YM + AI AY A+ N +
Sbjct: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKR 397
Query: 755 DGTLASKMGKA--LIKTHNYSMAITYYEAA--LKTGQKNYLCYDLAELLLKLKWYDKAEK 810
D +G+ ++K Y + YY A L+ L L E KL +A+K
Sbjct: 398 DYRAWYGLGQTYEILKMPFY--CLYYYRRAHQLRPNDSRML-VALGECYEKLNQLVEAKK 454
Query: 811 VLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARVLKRV 868
A A V +++ + K+ KL + +T +QA + + ++ +
Sbjct: 455 CYWRAYAVGDVEKMALV---------------KLAKLHEQLTESEQAAQCYIKYIQDI 497
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 38.5 bits (88), Expect = 0.043
Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 2/106 (1%)
Query: 896 AQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAAT 955
A DYEKA +FY+EAL + + + + + Y + D L C L L + N A
Sbjct: 505 ANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL-DCFLKLHAILRNSAEV 563
Query: 956 M-MMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCG 1000
+ +A++ ++ QA+ L Q++ P + LS+L +L R G
Sbjct: 564 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
Score = 36.6 bits (83), Expect = 0.16
Identities = 75/391 (19%), Positives = 149/391 (38%), Gaps = 43/391 (10%)
Query: 652 EEVRVTIANADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITC 711
+EV + + +A + GD++ AL ++ ++ + RE++ ++ + Y
Sbjct: 152 KEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTP--ENINLDLTYSVL 209
Query: 712 FREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHN 771
F ++ N + Y L + IV + N G L MG +K N
Sbjct: 210 FNLASQYSVN--------EMYAEALNTYQVIVKNKMFSNA----GILKMNMGNIYLKQRN 257
Query: 772 YSMAITYYEAAL------KTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELS 825
YS AI +Y AL + + ++ ++ Y A +H ++ P L
Sbjct: 258 YSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP--NLK 315
Query: 826 ALMEDGRCQVLLA---KVYSKMEKLGDAITALQQAR----------ELQARVLKR---VQ 869
A C + K+ +KL + + + L +K Q
Sbjct: 316 AGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQ 375
Query: 870 MEQPDAVPAQKHL--AAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARL 927
ME+ A+K++ +A++ A + + S A Y+ ++ + A + E N + + A
Sbjct: 376 MERERKAMAEKYIMTSAKLIAPVIETSFA-AGYDWCVEVVK-ASQYVELANDLEINKAVT 433
Query: 928 YLAQDDPDSCLRQCALLLQSD-QDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPDNY 986
YL Q D + + +L + D + AA ++ L + +D+ QA + + N
Sbjct: 434 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 493
Query: 987 MTLSRLIDLLRRCGKLEDVPRFFSMAEKRNS 1017
L+ + + G E F+ A + +S
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEALRNDS 524
Score = 34.3 bits (77), Expect = 0.81
Identities = 38/166 (22%), Positives = 68/166 (40%), Gaps = 5/166 (3%)
Query: 666 AQGDIERALSILQNVTAEQPYFIEAREKMADIYLK-HRKDKMLYITCFREIAERMANPRS 724
A GD E+A + EA + Y K +R D+ L CF ++ + N
Sbjct: 505 ANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL--DCFLKLHAILRNSAE 562
Query: 725 FLL-LGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAAL 783
L + + Y + P +AI Q ++ P D + SK+G+ + + S A YY +
Sbjct: 563 VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESY 622
Query: 784 KTGQKNYLCYD-LAELLLKLKWYDKAEKVLQHALAHEPVNELSALM 828
+ N + L + ++++KA + + A +P LM
Sbjct: 623 RYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLM 668
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 38.5 bits (88), Expect = 0.043
Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 2/106 (1%)
Query: 896 AQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAAT 955
A DYEKA +FY+EAL + + + + + Y + D L C L L + N A
Sbjct: 496 ANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL-DCFLKLHAILRNSAEV 554
Query: 956 M-MMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCG 1000
+ +A++ ++ QA+ L Q++ P + LS+L +L R G
Sbjct: 555 LYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
Score = 36.6 bits (83), Expect = 0.16
Identities = 75/391 (19%), Positives = 149/391 (38%), Gaps = 43/391 (10%)
Query: 652 EEVRVTIANADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITC 711
+EV + + +A + GD++ AL ++ ++ + RE++ ++ + Y
Sbjct: 143 KEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTP--ENINLDLTYSVL 200
Query: 712 FREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHN 771
F ++ N + Y L + IV + N G L MG +K N
Sbjct: 201 FNLASQYSVN--------EMYAEALNTYQVIVKNKMFSNA----GILKMNMGNIYLKQRN 248
Query: 772 YSMAITYYEAAL------KTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELS 825
YS AI +Y AL + + ++ ++ Y A +H ++ P L
Sbjct: 249 YSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAP--NLK 306
Query: 826 ALMEDGRCQVLLA---KVYSKMEKLGDAITALQQAR----------ELQARVLKR---VQ 869
A C + K+ +KL + + + L +K Q
Sbjct: 307 AGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQ 366
Query: 870 MEQPDAVPAQKHL--AAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARL 927
ME+ A+K++ +A++ A + + S A Y+ ++ + A + E N + + A
Sbjct: 367 MERERKAMAEKYIMTSAKLIAPVIETSFA-AGYDWCVEVVK-ASQYVELANDLEINKAVT 424
Query: 928 YLAQDDPDSCLRQCALLLQSD-QDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPDNY 986
YL Q D + + +L + D + AA ++ L + +D+ QA + + N
Sbjct: 425 YLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNP 484
Query: 987 MTLSRLIDLLRRCGKLEDVPRFFSMAEKRNS 1017
L+ + + G E F+ A + +S
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEALRNDS 515
Score = 34.3 bits (77), Expect = 0.81
Identities = 38/166 (22%), Positives = 68/166 (40%), Gaps = 5/166 (3%)
Query: 666 AQGDIERALSILQNVTAEQPYFIEAREKMADIYLK-HRKDKMLYITCFREIAERMANPRS 724
A GD E+A + EA + Y K +R D+ L CF ++ + N
Sbjct: 496 ANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEAL--DCFLKLHAILRNSAE 553
Query: 725 FLL-LGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAAL 783
L + + Y + P +AI Q ++ P D + SK+G+ + + S A YY +
Sbjct: 554 VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESY 613
Query: 784 KTGQKNYLCYD-LAELLLKLKWYDKAEKVLQHALAHEPVNELSALM 828
+ N + L + ++++KA + + A +P LM
Sbjct: 614 RYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLM 659
>gi|221307607 RANBP2-like and GRIP domain containing 3 [Homo
sapiens]
Length = 1758
Score = 37.4 bits (85), Expect = 0.096
Identities = 35/141 (24%), Positives = 57/141 (40%), Gaps = 6/141 (4%)
Query: 718 RMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAIT 777
R +PR+ LG Y E+A+ Y +++ NP L K+ + L K
Sbjct: 56 REMDPRAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAE 115
Query: 778 YY-EAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVL 836
Y+ E A K + Y L E LL + D K+ +EL +D +
Sbjct: 116 YWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLI-----QSELYVRPDDVHVNIR 170
Query: 837 LAKVYSKMEKLGDAITALQQA 857
L ++Y ++L DA+ +A
Sbjct: 171 LVELYRSTKRLKDAVARCHEA 191
>gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo
sapiens]
Length = 1758
Score = 37.4 bits (85), Expect = 0.096
Identities = 35/141 (24%), Positives = 57/141 (40%), Gaps = 6/141 (4%)
Query: 718 RMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAIT 777
R +PR+ LG Y E+A+ Y +++ NP L K+ + L K
Sbjct: 56 REMDPRAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAK 115
Query: 778 YY-EAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVL 836
Y+ E A K + Y L E LL + D K+ +EL +D +
Sbjct: 116 YWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLI-----QSELYVRPDDVHVNIR 170
Query: 837 LAKVYSKMEKLGDAITALQQA 857
L ++Y ++L DA+ +A
Sbjct: 171 LVELYRSTKRLKDAVARCHEA 191
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 37.0 bits (84), Expect = 0.12
Identities = 68/314 (21%), Positives = 114/314 (36%), Gaps = 53/314 (16%)
Query: 967 DYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQ 1026
D E AV L+ PD Y S L +LL+ G+LE+ + A + +P F
Sbjct: 128 DMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKA------IETQPNFA 181
Query: 1027 YC---KGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFEN- 1082
G GE A+ HF KA N ++ +N N +F+
Sbjct: 182 VAWSNLGCVFNAQGEIWLAIHHFEKA-------VTLDPNFLDAYINLGNVLKEARIFDRA 234
Query: 1083 ----------------LDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIME 1126
+ G+L +Q + LA+ T + + EL+P +
Sbjct: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAI-ELQP---------HFPD 284
Query: 1127 NYCLMAT--KQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIA 1184
YC +A K+K +V +A + + H +L +A R + ++
Sbjct: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA-------NIKREQGNIEEAV 337
Query: 1185 KMNWNAIDA-EEFEKSWLLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEK 1243
++ A++ EF + LA + Q K A K +R + + AY MG +++
Sbjct: 338 RLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKE 397
Query: 1244 EQAYTDAALNYEMA 1257
Q A Y A
Sbjct: 398 MQDVQGALQCYTRA 411
Score = 36.2 bits (82), Expect = 0.21
Identities = 60/258 (23%), Positives = 104/258 (40%), Gaps = 30/258 (11%)
Query: 728 LGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQ 787
LG+ + EEA Y +A+ P S +G +AI ++E A+ T
Sbjct: 153 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAV-TLD 211
Query: 788 KNYL--CYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKME 845
N+L +L +L + + +D+A AL+ P + A++ LA VY +
Sbjct: 212 PNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGN-----LACVYYEQG 263
Query: 846 KLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIK 905
+ AI ++A ELQ PDA + E K SVA+ A
Sbjct: 264 LIDLAIDTYRRAIELQPHF--------PDAYCNLANALKE------KGSVAE-----AED 304
Query: 906 FYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRK 965
Y AL C T + LA + Q + + +R L+ + AA +A ++ ++
Sbjct: 305 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 364
Query: 966 QDYEQAVFHLQQLLERKP 983
++A+ H ++ + P
Sbjct: 365 GKLQEALMHYKEAIRISP 382
Score = 35.0 bits (79), Expect = 0.47
Identities = 29/108 (26%), Positives = 50/108 (46%), Gaps = 6/108 (5%)
Query: 945 LQSDQDNEAATMMMADLMFRKQ---DYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGK 1001
+ S N A + +A+L R+ D+E A H QL ++PDN L L + +C +
Sbjct: 1 MASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR 60
Query: 1002 LEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHFNKA 1049
L+ F ++A K+N L + +Y G+ +A+ H+ A
Sbjct: 61 LDRSAHFSTLAIKQN--PLLAEAYSNLGNVYK-ERGQLQEAIEHYRHA 105
Score = 33.9 bits (76), Expect = 1.1
Identities = 56/270 (20%), Positives = 104/270 (38%), Gaps = 36/270 (13%)
Query: 506 GDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFKVRDYPLY 565
G+I A ++ + + +P++ DA++ L V ++ ++ +++ L ++ +
Sbjct: 195 GEIWLAIHHFEKAVTLDPNFLDAYINLGNVL---KEARIFDRAVAAYLRALSLSPNHAVV 251
Query: 566 HLIKAQSQKKMGEIADAIKTLHMAMSL-----PGMKRIGASTKSKDRKTEVDTSHRLSIF 620
H A + G I AI T A+ L + + K K E + + ++
Sbjct: 252 HGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALR 311
Query: 621 L---------ELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN-ADLALAQGDI 670
L L ++ R G EA ++ + A+ F E +N A + QG +
Sbjct: 312 LCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQQGKL 367
Query: 671 ERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGD 730
+ AL + P F +A M + LK +D + C+ + NP D
Sbjct: 368 QEALMHYKEAIRISPTFADAYSNMGNT-LKEMQDVQGALQCYTRAIQ--INP----AFAD 420
Query: 731 AYMNILEPE-------EAIVAYEQALNQNP 753
A+ N+ EAI +Y AL P
Sbjct: 421 AHSNLASIHKDSGNIPEAIASYRTALKLKP 450
Score = 32.7 bits (73), Expect = 2.4
Identities = 27/126 (21%), Positives = 54/126 (42%), Gaps = 4/126 (3%)
Query: 661 ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRK--DKMLYITCFREIAER 718
A++ QG+IE A+ + + P F A +A + + K + +++ I+
Sbjct: 324 ANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 383
Query: 719 MANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITY 778
A+ ++ +G+ + + + A+ Y +A+ NP S + + N AI
Sbjct: 384 FAD--AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIAS 441
Query: 779 YEAALK 784
Y ALK
Sbjct: 442 YRTALK 447
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 37.0 bits (84), Expect = 0.12
Identities = 68/314 (21%), Positives = 114/314 (36%), Gaps = 53/314 (16%)
Query: 967 DYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQ 1026
D E AV L+ PD Y S L +LL+ G+LE+ + A + +P F
Sbjct: 138 DMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKA------IETQPNFA 191
Query: 1027 YC---KGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFEN- 1082
G GE A+ HF KA N ++ +N N +F+
Sbjct: 192 VAWSNLGCVFNAQGEIWLAIHHFEKA-------VTLDPNFLDAYINLGNVLKEARIFDRA 244
Query: 1083 ----------------LDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIME 1126
+ G+L +Q + LA+ T + + EL+P +
Sbjct: 245 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAI-ELQP---------HFPD 294
Query: 1127 NYCLMAT--KQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIA 1184
YC +A K+K +V +A + + H +L +A R + ++
Sbjct: 295 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA-------NIKREQGNIEEAV 347
Query: 1185 KMNWNAIDA-EEFEKSWLLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEK 1243
++ A++ EF + LA + Q K A K +R + + AY MG +++
Sbjct: 348 RLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKE 407
Query: 1244 EQAYTDAALNYEMA 1257
Q A Y A
Sbjct: 408 MQDVQGALQCYTRA 421
Score = 36.2 bits (82), Expect = 0.21
Identities = 60/258 (23%), Positives = 104/258 (40%), Gaps = 30/258 (11%)
Query: 728 LGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQ 787
LG+ + EEA Y +A+ P S +G +AI ++E A+ T
Sbjct: 163 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAV-TLD 221
Query: 788 KNYL--CYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKME 845
N+L +L +L + + +D+A AL+ P + A++ LA VY +
Sbjct: 222 PNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGN-----LACVYYEQG 273
Query: 846 KLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIK 905
+ AI ++A ELQ PDA + E K SVA+ A
Sbjct: 274 LIDLAIDTYRRAIELQPHF--------PDAYCNLANALKE------KGSVAE-----AED 314
Query: 906 FYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRK 965
Y AL C T + LA + Q + + +R L+ + AA +A ++ ++
Sbjct: 315 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 374
Query: 966 QDYEQAVFHLQQLLERKP 983
++A+ H ++ + P
Sbjct: 375 GKLQEALMHYKEAIRISP 392
Score = 33.9 bits (76), Expect = 1.1
Identities = 56/270 (20%), Positives = 104/270 (38%), Gaps = 36/270 (13%)
Query: 506 GDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFKVRDYPLY 565
G+I A ++ + + +P++ DA++ L V ++ ++ +++ L ++ +
Sbjct: 205 GEIWLAIHHFEKAVTLDPNFLDAYINLGNVL---KEARIFDRAVAAYLRALSLSPNHAVV 261
Query: 566 HLIKAQSQKKMGEIADAIKTLHMAMSL-----PGMKRIGASTKSKDRKTEVDTSHRLSIF 620
H A + G I AI T A+ L + + K K E + + ++
Sbjct: 262 HGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALR 321
Query: 621 L---------ELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN-ADLALAQGDI 670
L L ++ R G EA ++ + A+ F E +N A + QG +
Sbjct: 322 LCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQQGKL 377
Query: 671 ERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGD 730
+ AL + P F +A M + LK +D + C+ + NP D
Sbjct: 378 QEALMHYKEAIRISPTFADAYSNMGNT-LKEMQDVQGALQCYTRAIQ--INP----AFAD 430
Query: 731 AYMNILEPE-------EAIVAYEQALNQNP 753
A+ N+ EAI +Y AL P
Sbjct: 431 AHSNLASIHKDSGNIPEAIASYRTALKLKP 460
Score = 33.5 bits (75), Expect = 1.4
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 3/92 (3%)
Query: 958 MADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNS 1017
+A ++ D+E A H QL ++PDN L L + +C +L+ F ++A K+N
Sbjct: 27 LAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQN- 85
Query: 1018 RAKLEPGFQYCKGLYLWYTGEPNDALRHFNKA 1049
L + +Y G+ +A+ H+ A
Sbjct: 86 -PLLAEAYSNLGNVYK-ERGQLQEAIEHYRHA 115
Score = 32.7 bits (73), Expect = 2.4
Identities = 27/126 (21%), Positives = 54/126 (42%), Gaps = 4/126 (3%)
Query: 661 ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRK--DKMLYITCFREIAER 718
A++ QG+IE A+ + + P F A +A + + K + +++ I+
Sbjct: 334 ANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT 393
Query: 719 MANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITY 778
A+ ++ +G+ + + + A+ Y +A+ NP S + + N AI
Sbjct: 394 FAD--AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIAS 451
Query: 779 YEAALK 784
Y ALK
Sbjct: 452 YRTALK 457
>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
Length = 2555
Score = 37.0 bits (84), Expect = 0.12
Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 10/144 (6%)
Query: 566 HLIKAQSQKKMG-EIADAIKTLHMAMSLPGMKRIGASTKSKDRKTEVDTSHRLSIFLELI 624
HL++ + +++ E + K ++M + +K + + +D + RL + L L+
Sbjct: 285 HLLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRLL 344
Query: 625 DVHRLNGEQH---EATKVLQDA---IHEFSGTSEEVRVTIANADLALAQGDIERALSILQ 678
+ NG+ + E KV+ H S EE +T + Q +I LSI+
Sbjct: 345 QISSFNGKMNALNEINKVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNI---LSIVL 401
Query: 679 NVTAEQPYFIEAREKMADIYLKHR 702
+ QP ++E EK+ +K +
Sbjct: 402 QDSLHQPQYVEKLEKILRFVIKEK 425
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 37.0 bits (84), Expect = 0.12
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 17/164 (10%)
Query: 715 IAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLA------SKMGKALIK 768
+ +R A R+F LG+ + + +A++A+EQ L + G A S +G A I
Sbjct: 195 LGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIF 254
Query: 769 THNYSMAITYYEAALKTGQ-------KNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPV 821
+ A YY+ L + + CY L L+ Y+KA + + L H +
Sbjct: 255 LGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKA---IDYHLKHLAI 311
Query: 822 -NELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARV 864
EL+ + +GR L Y+ + A+ ++ E+ V
Sbjct: 312 AQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREV 355
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,757,779
Number of Sequences: 37866
Number of extensions: 1861604
Number of successful extensions: 6263
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 5888
Number of HSP's gapped (non-prelim): 398
length of query: 1316
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1202
effective length of database: 13,930,794
effective search space: 16744814388
effective search space used: 16744814388
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.