Search of human proteins with 115583677

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
         (1998 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  3989   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  3484   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  3484   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  3482   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  3359   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  3263   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  3261   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  3030   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2969   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2407   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2391   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2390   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2386   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2340   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2315   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2097   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1846   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1303   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1278   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1006   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   334   4e-91
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   334   4e-91
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...   331   4e-90
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...   331   5e-90
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...   331   5e-90

>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 3989 bits (10346), Expect = 0.0
 Identities = 1998/1998 (100%), Positives = 1998/1998 (100%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60
            MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN
Sbjct: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180

Query: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNY 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNY
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNY 300

Query: 301  NGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNY 360
            NGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNY
Sbjct: 301  NGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNY 360

Query: 361  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 420
            GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA
Sbjct: 361  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 420

Query: 421  VVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLS 480
            VVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLS
Sbjct: 421  VVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLS 480

Query: 481  DSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEG 540
            DSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEG
Sbjct: 481  DSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEG 540

Query: 541  NRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED 600
            NRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED
Sbjct: 541  NRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED 600

Query: 601  NESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVP 660
            NESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVP
Sbjct: 601  NESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVP 660

Query: 661  TSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESR 720
            TSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESR
Sbjct: 661  TSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESR 720

Query: 721  QKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYP 780
            QKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYP
Sbjct: 721  QKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYP 780

Query: 781  MTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLAN 840
            MTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLAN
Sbjct: 781  MTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLAN 840

Query: 841  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 900
            VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL
Sbjct: 841  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 900

Query: 901  FGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTV 960
            FGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTV
Sbjct: 901  FGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTV 960

Query: 961  FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIY 1020
            FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIY
Sbjct: 961  FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIY 1020

Query: 1021 EFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSS 1080
            EFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSS
Sbjct: 1021 EFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSS 1080

Query: 1081 VEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSS 1140
            VEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSS
Sbjct: 1081 VEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSS 1140

Query: 1141 SEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTC 1200
            SEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTC
Sbjct: 1141 SEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTC 1200

Query: 1201 FRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKW 1260
            FRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKW
Sbjct: 1201 FRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKW 1260

Query: 1261 VAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1320
            VAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE
Sbjct: 1261 VAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1320

Query: 1321 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVN 1380
            GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVN
Sbjct: 1321 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVN 1380

Query: 1381 NHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1440
            NHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQP
Sbjct: 1381 NHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1440

Query: 1441 KYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM 1500
            KYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM
Sbjct: 1441 KYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM 1500

Query: 1501 KKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTT 1560
            KKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTT
Sbjct: 1501 KKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTT 1560

Query: 1561 ILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVS 1620
            ILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVS
Sbjct: 1561 ILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVS 1620

Query: 1621 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSN 1680
            PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSN
Sbjct: 1621 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSN 1680

Query: 1681 FAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSS 1740
            FAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSS
Sbjct: 1681 FAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSS 1740

Query: 1741 VKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEV 1800
            VKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEV
Sbjct: 1741 VKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEV 1800

Query: 1801 WEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAF 1860
            WEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAF
Sbjct: 1801 WEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAF 1860

Query: 1861 TKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLL 1920
            TKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLL
Sbjct: 1861 TKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLL 1920

Query: 1921 KRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTK 1980
            KRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTK
Sbjct: 1921 KRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTK 1980

Query: 1981 PIVEKHEQEGKDEKAKGK 1998
            PIVEKHEQEGKDEKAKGK
Sbjct: 1981 PIVEKHEQEGKDEKAKGK 1998


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3484 bits (9034), Expect = 0.0
 Identities = 1759/2005 (87%), Positives = 1875/2005 (93%), Gaps = 14/2005 (0%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD-DDENGPKPNSDLEAGK 59
            M Q+VLVPPGPDSF FFTRESLAAIE+RIAEEKAK PK ++KD DDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIVLNKGKAI RFSAT ALYILTPFNP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKI+ARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITV 298
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP N+S E +     N ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 299  NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            + NGT  N TV  F+W  YI+D  + YFLEG  DALLCGNSSDAGQCPEGY+CVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ AA A AS  SR+ S AG 
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQ-AAAAAASAESRDFSGAGG 479

Query: 479  L---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535
            +   S+SSS ASKLSSKS KE +NRRKK+KQKEQSG EEK+ D  +KSESEDSIRRKGFR
Sbjct: 480  IGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN-DRVRKSESEDSIRRKGFR 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS+EG+RLTYEKR+SSPHQSLLSIRGSLFSPRRNSR SLFSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFEDN+SRRDSLFVP RHGERR+SN+SQ SR+SR+L + P NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
            GPS  TS  GQLLPEGTTTETE+RKRRSSS+HVSMD LEDP+ RQRAMSIASILTNT+EE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWYKF+N+ LIWDC   WLKVKH+VNLVVMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VL+VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV+LSL+E
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI++DC+LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCLTVFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ +V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            KRKI EFIQ++F+RKQK LDEIKPL+DLNNKKDSC+SNHT  EIGKDL+YLKD NGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            IG  SSVEKY++DESDYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSESD+EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVDIGAP E EQP VEPEE+LEPEACFTE CV++FKCCQI++EEG+GK W
Sbjct: 1136 N-ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLW 1194

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC++IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1195 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1254

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+Q YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL
Sbjct: 1255 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1314

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN TTG+ 
Sbjct: 1315 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM 1374

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FD+  VNN+++C  LIE N+TARWKNVKVNFDNVG GYLSLLQVATFKGWMDIMYAAVDS
Sbjct: 1375 FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            RNVELQPKYE++LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1494

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDD
Sbjct: 1495 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDD 1554

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            QS+ +T IL  INLVFIVLFTGECVLKLISLR+YYFTIGWNIFDFVVVILSIVGMFLAEL
Sbjct: 1555 QSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1674

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1675 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPD 1734

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
            K +PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FA AL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1795 FEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1854

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSY+PITTTLKRKQEEVSA+IIQR
Sbjct: 1855 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQR 1914

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
            AYRR+LLK+ VK+ S  Y K+K K      IKED +ID++NENS  EKTD+T ST + PP
Sbjct: 1915 AYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTS-PP 1973

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  +++ KGK
Sbjct: 1974 SYDSVTKPEKEKFEKDKSEKEDKGK 1998


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3484 bits (9034), Expect = 0.0
 Identities = 1759/2005 (87%), Positives = 1875/2005 (93%), Gaps = 14/2005 (0%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD-DDENGPKPNSDLEAGK 59
            M Q+VLVPPGPDSF FFTRESLAAIE+RIAEEKAK PK ++KD DDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIVLNKGKAI RFSAT ALYILTPFNP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKI+ARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITV 298
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP N+S E +     N ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 299  NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            + NGT  N TV  F+W  YI+D  + YFLEG  DALLCGNSSDAGQCPEGY+CVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ AA A AS  SR+ S AG 
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQ-AAAAAASAESRDFSGAGG 479

Query: 479  L---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535
            +   S+SSS ASKLSSKS KE +NRRKK+KQKEQSG EEK+ D  +KSESEDSIRRKGFR
Sbjct: 480  IGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN-DRVRKSESEDSIRRKGFR 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS+EG+RLTYEKR+SSPHQSLLSIRGSLFSPRRNSR SLFSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFEDN+SRRDSLFVP RHGERR+SN+SQ SR+SR+L + P NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
            GPS  TS  GQLLPEGTTTETE+RKRRSSS+HVSMD LEDP+ RQRAMSIASILTNT+EE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWYKF+N+ LIWDC   WLKVKH+VNLVVMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VL+VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV+LSL+E
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI++DC+LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCLTVFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ +V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            KRKI EFIQ++F+RKQK LDEIKPL+DLNNKKDSC+SNHT  EIGKDL+YLKD NGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            IG  SSVEKY++DESDYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSESD+EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVDIGAP E EQP VEPEE+LEPEACFTE CV++FKCCQI++EEG+GK W
Sbjct: 1136 N-ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLW 1194

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC++IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1195 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1254

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+Q YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL
Sbjct: 1255 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1314

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN TTG+ 
Sbjct: 1315 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM 1374

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FD+  VNN+++C  LIE N+TARWKNVKVNFDNVG GYLSLLQVATFKGWMDIMYAAVDS
Sbjct: 1375 FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            RNVELQPKYE++LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1494

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDD
Sbjct: 1495 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDD 1554

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            QS+ +T IL  INLVFIVLFTGECVLKLISLR+YYFTIGWNIFDFVVVILSIVGMFLAEL
Sbjct: 1555 QSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1674

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1675 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPD 1734

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
            K +PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FA AL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1795 FEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1854

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSY+PITTTLKRKQEEVSA+IIQR
Sbjct: 1855 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQR 1914

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
            AYRR+LLK+ VK+ S  Y K+K K      IKED +ID++NENS  EKTD+T ST + PP
Sbjct: 1915 AYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTS-PP 1973

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  +++ KGK
Sbjct: 1974 SYDSVTKPEKEKFEKDKSEKEDKGK 1998


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 3482 bits (9029), Expect = 0.0
 Identities = 1758/2005 (87%), Positives = 1875/2005 (93%), Gaps = 14/2005 (0%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD-DDENGPKPNSDLEAGK 59
            M Q+VLVPPGPDSF FFTRESLAAIE+RIAEEKAK PK ++KD DDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIVLNKGKAI RFSAT ALYILTPFNP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKI+ARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDFTVITFAYVTEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITV 298
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP N+S E +     N ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 299  NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            + NGT  N TV  F+W  YI+D  + YFLEG  DALLCGNSSDAGQCPEGY+CVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ AA A AS  SR+ S AG 
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQ-AAAAAASAESRDFSGAGG 479

Query: 479  L---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535
            +   S+SSS ASKLSSKS KE +NRRKK+KQKEQSG EEK+ D  +KSESEDSIRRKGFR
Sbjct: 480  IGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN-DRVRKSESEDSIRRKGFR 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS+EG+RLTYEKR+SSPHQSLLSIRGSLFSPRRNSR SLFSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFEDN+SRRDSLFVP RHGERR+SN+SQ SR+SR+L + P NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
            GPS  TS  GQLLPEGTTTETE+RKRRSSS+HVSMD LEDP+ RQRAMSIASILTNT+EE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWYKF+N+ LIWDC   WLKVKH+VNLVVMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VL+VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV+LSL+E
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI++DC+LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCLTVFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ +V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            KRKI EFIQ++F+RKQK LDEIKPL+DLNNKKDSC+SNHT  EIGKDL+YLKD NGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            IG  SSVEKY++DESDYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSESD+EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVDIGAP E EQP VEPEE+LEPEACFTE CV++FKCCQI++EEG+GK W
Sbjct: 1136 N-ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLW 1194

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC++IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1195 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1254

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+Q YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL
Sbjct: 1255 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1314

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN TTG+ 
Sbjct: 1315 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM 1374

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FD+  VNN+++C  LIE N+TARWKNVKVNFDNVG GYLSLLQVATFKGWMDIMYAAVDS
Sbjct: 1375 FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            RNVELQPKYE++LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1494

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDD
Sbjct: 1495 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDD 1554

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            QS+ +T IL  INLVFIVLFTGECVLKLISLR+YYFTIGWNIFDFVVVILSIVGMFLAEL
Sbjct: 1555 QSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1674

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1675 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPD 1734

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
            K +PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FA AL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1795 FEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1854

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSY+PITTTLKRKQEEVSA+IIQR
Sbjct: 1855 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQR 1914

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
            AYRR+LLK+ VK+ S  Y K+K K      IKED +ID++NENS  EKTD+T ST + PP
Sbjct: 1915 AYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTS-PP 1973

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  +++ KGK
Sbjct: 1974 SYDSVTKPEKEKFEKDKSEKEDKGK 1998


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 3359 bits (8710), Expect = 0.0
 Identities = 1690/2005 (84%), Positives = 1829/2005 (91%), Gaps = 19/2005 (0%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60
            M Q +LVPPGP+SF  FTRESLAAIE+R AEEKAK PK ++ +DDEN PKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIV+NKGKAIFRFSATSALYILTP NP+RKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKI+ARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITVN 299
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP++++ E ++    N T++
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 300  YNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN 359
             NGT +N T+  F+WK YI D  + Y L+G  D LLCGN SDAGQCPEGY+CVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 360  YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLIL 419
            YGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 420  AVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRL 479
            AVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ  A A+A+  SR+ S  G L
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAA--SRDFSGIGGL 478

Query: 480  SD---SSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE-DEFQKSESEDSIRRKGFR 535
             +   SSSEASKLSSKSAKE RNRRKKR+Q+E   G  K E D F KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS++GNRLT +K++ SPHQSLLSIRGSLFSPRRNS+TS+FSFRGRAKDVGSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFED+ESRRDSLFVP RHGERRNSN+SQ S SSRM+   PANGKMHSTVDCNGVVSLVG
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
            GPS  TSP GQL PEGTTTETE+RKRR SS+ +SM+ LED S RQRA+SIASILTNT+EE
Sbjct: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWY+F+N+FLIWDC   WLKVKH+VNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VLTVGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IV+LSL+E
Sbjct: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCL VFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ YV
Sbjct: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            K K+ E  Q++F RK K+++  +      NK DSCMSN+T  EI K+L+YL+D NGTTSG
Sbjct: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            +GTGSSVEKY+IDE+DYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSES+LEESKEKL
Sbjct: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVD+  P E EQ   EPEE L+PEACFTEGC+++F  CQ++ EEG+GK W
Sbjct: 1134 N-ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW 1192

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC+ IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1193 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1252

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+QTYFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPL
Sbjct: 1253 LEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPL 1312

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG+ 
Sbjct: 1313 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM 1372

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FDI DVNN +DC  L    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDS
Sbjct: 1373 FDISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1429

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            R+V+LQP YEE+LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1430 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1489

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1490 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1549

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            Q +Y+T +LSRINLVFIVLFTGE VLKL+SLRHYYFTIGWNIFDFVVVILSIVGMFLAE+
Sbjct: 1550 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1609

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1610 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1669

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1670 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1729

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
             ++PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1730 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1789

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1790 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1849

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSY+PITTTLKRKQEEVSA IIQR
Sbjct: 1850 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1909

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
             +R +LLK+ +K  S  YNK  IKG  +L IK+DMIID++N NS  EKTD + ST + PP
Sbjct: 1910 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTS-PP 1968

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  ++++KGK
Sbjct: 1969 SYDSVTKPDKEKFEKDKPEKESKGK 1993


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 3263 bits (8461), Expect = 0.0
 Identities = 1652/2005 (82%), Positives = 1789/2005 (89%), Gaps = 68/2005 (3%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60
            M Q +LVPPGP+SF  FTRESLAAIE+R AEEKAK PK ++ +DDEN PKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIV+NKGKAIFRFSATSALYILTP NP+RKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKI+ARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITVN 299
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP++++ E ++    N T++
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 300  YNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN 359
             NGT +N T+  F+WK YI D  + Y L+G  D LLCGN SDAGQCPEGY+CVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 360  YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLIL 419
            YGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 420  AVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRL 479
            AVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ  A A+A+  SR+ S  G L
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAA--SRDFSGIGGL 478

Query: 480  SD---SSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE-DEFQKSESEDSIRRKGFR 535
             +   SSSEASKLSSKSAKE RNRRKKR+Q+E   G  K E D F KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS++GNRLT +K++ SPHQSLLSIRGSLFSPRRNS+TS+FSFRGRAKDVGSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFED+ESRRDSLFVP RHGERRNSN                                  
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
                           GTTTETE+RKRR SS+ +SM+ LED S RQRA+SIASILTNT+EE
Sbjct: 625  ---------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 669

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWY+F+N+FLIWDC   WLKVKH+VNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 670  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 729

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VLTVGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IV+LSL+E
Sbjct: 730  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 789

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 790  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 849

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 850  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 909

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCL VFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ YV
Sbjct: 910  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 969

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            K K+ E  Q++F RK K+++  +      NK DSCMSN+T  EI K+L+YL+D NGTTSG
Sbjct: 970  KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1024

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            +GTGSSVEKY+IDE+DYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSES+LEESKEKL
Sbjct: 1025 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1084

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVD+  P E EQ   EPEE L+PEACFTEGC+++F  CQ++ EEG+GK W
Sbjct: 1085 N-ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW 1143

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC+ IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1144 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1203

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+QTYFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPL
Sbjct: 1204 LEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPL 1263

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG+ 
Sbjct: 1264 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM 1323

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FDI DVNN +DC  L    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDS
Sbjct: 1324 FDISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            R+V+LQP YEE+LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            Q +Y+T +LSRINLVFIVLFTGE VLKL+SLRHYYFTIGWNIFDFVVVILSIVGMFLAE+
Sbjct: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
             ++PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSY+PITTTLKRKQEEVSA IIQR
Sbjct: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
             +R +LLK+ +K  S  YNK  IKG  +L IK+DMIID++N NS  EKTD + ST + PP
Sbjct: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTS-PP 1919

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  ++++KGK
Sbjct: 1920 SYDSVTKPDKEKFEKDKPEKESKGK 1944


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 3261 bits (8455), Expect = 0.0
 Identities = 1651/2005 (82%), Positives = 1788/2005 (89%), Gaps = 68/2005 (3%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60
            M Q +LVPPGP+SF  FTRESLAAIE+R AEEKAK PK ++ +DDEN PKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIV+NKGKAIFRFSATSALYILTP NP+RKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKI+ARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDF+VI  AYVTEFV LGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITVN 299
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP++++ E ++    N T++
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 300  YNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN 359
             NGT +N T+  F+WK YI D  + Y L+G  D LLCGN SDAGQCPEGY+CVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 360  YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLIL 419
            YGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 420  AVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRL 479
            AVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ  A A+A+  SR+ S  G L
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAA--SRDFSGIGGL 478

Query: 480  SD---SSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE-DEFQKSESEDSIRRKGFR 535
             +   SSSEASKLSSKSAKE RNRRKKR+Q+E   G  K E D F KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595
            FS++GNRLT +K++ SPHQSLLSIRGSLFSPRRNS+TS+FSFRGRAKDVGSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655
            STFED+ESRRDSLFVP RHGERRNSN                                  
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624

Query: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715
                           GTTTETE+RKRR SS+ +SM+ LED S RQRA+SIASILTNT+EE
Sbjct: 625  ---------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 669

Query: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775
            LEESRQKCPPCWY+F+N+FLIWDC   WLKVKH+VNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 670  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 729

Query: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835
            MEHYPMT+ F++VLTVGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IV+LSL+E
Sbjct: 730  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 789

Query: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 790  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 849

Query: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955
            VGMQLFGKSYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 850  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 909

Query: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015
            MCL VFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ YV
Sbjct: 910  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 969

Query: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074
            K K+ E  Q++F RK K+++  +      NK DSCMSN+T  EI K+L+YL+D NGTTSG
Sbjct: 970  KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1024

Query: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134
            +GTGSSVEKY+IDE+DYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSES+LEESKEKL
Sbjct: 1025 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1084

Query: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193
            N ++SSSEGSTVD+  P E EQ   EPEE L+PEACFTEGC+++F  CQ++ EEG+GK W
Sbjct: 1085 N-ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW 1143

Query: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253
            WNLR+TC+ IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1144 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1203

Query: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313
            LEMLLKWVAYG+QTYFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPL
Sbjct: 1204 LEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPL 1263

Query: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373
            RALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG+ 
Sbjct: 1264 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM 1323

Query: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433
            FDI DVNN +DC  L    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDS
Sbjct: 1324 FDISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493
            R+V+LQP YEE+LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500

Query: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613
            Q +Y+T +LSRINLVFIVLFTGE VLKL+SLRHYYFTIGWNIFDFVVVILSIVGMFLAE+
Sbjct: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560

Query: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620

Query: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733
            AIFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680

Query: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793
             ++PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740

Query: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853
            FEMFYEVWEKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800

Query: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913
            LDILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSY+PITTTLKRKQEEVSA IIQR
Sbjct: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860

Query: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973
             +R +LLK+ +K  S  YNK  IKG  +L IK+DMIID++N NS  EKTD + ST + PP
Sbjct: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTS-PP 1919

Query: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998
            SYD VTKP  EK E++  ++++KGK
Sbjct: 1920 SYDSVTKPDKEKFEKDKPEKESKGK 1944


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 3030 bits (7856), Expect = 0.0
 Identities = 1533/1997 (76%), Positives = 1725/1997 (86%), Gaps = 32/1997 (1%)

Query: 5    VLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFI 64
            +L PPGP SF  FT++SLA IE+RIAE K+K PK +KKDDDE  PKP+SDLEAGK LPFI
Sbjct: 3    MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFI 62

Query: 65   YGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKI 124
            YGDIPP MVSEPLEDLDPYY +KKTFIVLNKGK IFRF+AT ALY+L+PF+PLR+I+IKI
Sbjct: 63   YGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKI 122

Query: 125  LVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFT 184
            LVHSLFSMLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KI+ARGFC+ +FT
Sbjct: 123  LVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFT 182

Query: 185  FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 244
            FLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV
Sbjct: 183  FLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 242

Query: 245  KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTL 304
            KKLSDVMILTVFCLSVFALIGLQLFMGNL++KC +          +S+E N T+    ++
Sbjct: 243  KKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFR----------NSLENNETLE---SI 289

Query: 305  INETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTS 364
            +N    E D++      +Y Y+LEG  DALLCG S+D+GQCPEGY CVK GRNP+YGYTS
Sbjct: 290  MNTLESEEDFR------KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTS 343

Query: 365  FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAM 424
            FDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILAVVAM
Sbjct: 344  FDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAM 403

Query: 425  AYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSS 484
            AYEEQNQA +EEA+QKE EFQQM+++LKK+QE A+  A A A   S   S    LS+SSS
Sbjct: 404  AYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSS 463

Query: 485  EASKLSSKSAKERRNRRKKRKQKEQSGGEEK-DEDEFQKSESEDSIRRKGFRFSIEGNRL 543
            E SKLSSKSAKERRNRRKK+ QK+ S GEEK D ++  KSESEDSIRRK F   +EG+R 
Sbjct: 464  ETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRR 523

Query: 544  TYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNES 603
             +EKR S+P+QS LSIRGSLFS RR+SRTSLFSF+GR +D+GSE +FADDEHS F DNES
Sbjct: 524  AHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNES 583

Query: 604  RRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSP 663
            RR SLFVP R  ERR+SN+SQ SRS  ML   P NGKMHS VDCNGVVSLV G S    P
Sbjct: 584  RRGSLFVPHRPQERRSSNISQASRSPPML---PVNGKMHSAVDCNGVVSLVDGRSALMLP 640

Query: 664  VGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKC 723
             GQLLPEGTT +   +KRR SS+ +S D L DP+ RQRAMS ASILTNTVEELEESRQKC
Sbjct: 641  NGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKC 699

Query: 724  PPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTD 783
            PP WY+F++ FLIW+CSPYW+K K  +  +VMDPFVDLAITICIVLNTLFMAMEH+PMT+
Sbjct: 700  PPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759

Query: 784  HFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
             F NVL +GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IVTLSLVEL LA+VEG
Sbjct: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819

Query: 844  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903
            LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
Sbjct: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879

Query: 904  SYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMM 963
            SYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCL V+MM
Sbjct: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 939

Query: 964  VMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFI 1023
            VMVIGNLVVLNLFLALLLSSFS+DNL A ++D + NNLQIAV R+ KG+ YVK+ + EFI
Sbjct: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFI 999

Query: 1024 QQSFIRKQKILDEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGTGSSVE 1082
             ++F +K KI  EI+  +DLN KK++ +SNHT AE+ K  ++LK+ +  +   G GSSV+
Sbjct: 1000 LKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGSSVD 1056

Query: 1083 KYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSE 1142
            K+++++SD  SFI+NPSLTVTVPIA GESD EN+N E+ SS+SD E SK +LN SSSS E
Sbjct: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSS-E 1115

Query: 1143 GSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCF 1201
             STVD   P E E+   EP  + EPEACFT+GCV+RF CCQ+N+E G+GK WWN+R+TC+
Sbjct: 1116 CSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCY 1175

Query: 1202 RIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWV 1261
            +IVEH+WFE+FIV MILLSSGALAFEDIYI+++KTIK +LEYADK+FTYIFILEMLLKW+
Sbjct: 1176 KIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWI 1235

Query: 1262 AYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEG 1321
            AYGY+TYFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSRFEG
Sbjct: 1236 AYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEG 1295

Query: 1322 MRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNN 1381
            MRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CINTT G RF    V N
Sbjct: 1296 MRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPN 1355

Query: 1382 HTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPK 1441
             ++C  L+  ++  RWKN+KVNFDNVG GYLSLLQVATFKGW  IMYAAVDS NV+ QPK
Sbjct: 1356 RSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPK 1415

Query: 1442 YEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK 1501
            YE SLYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMK
Sbjct: 1416 YEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK 1475

Query: 1502 KLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTI 1561
            KLGSKKPQKPIPRPGNK QG +FD VT Q FDISIM+LICLNMVTMMVE + QS+++T +
Sbjct: 1476 KLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEV 1535

Query: 1562 LSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSP 1621
            L  IN+VFI+LFTGECVLKLISLRHYYFT+GWNIFDFVVVI+SIVGMFLA+LIE YFVSP
Sbjct: 1536 LYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSP 1595

Query: 1622 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1681
            TLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF
Sbjct: 1596 TLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1655

Query: 1682 AYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSV 1741
            AYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDP KV+PGSSV
Sbjct: 1656 AYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV 1715

Query: 1742 KGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVW 1801
            +GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYEVW
Sbjct: 1716 EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVW 1775

Query: 1802 EKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFT 1861
            EKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHCLDILFAFT
Sbjct: 1776 EKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFT 1835

Query: 1862 KRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLK 1921
            KRVLGESGEMD+LR QMEERFM++NPSKVSY+PITTTLKRKQE+VSA +IQRAYRR+ L+
Sbjct: 1836 KRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLR 1895

Query: 1922 RTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKP 1981
            + VK  S  Y K+  +   +LL K+DM  D +NENS  EKTD T ST + PPSYD VTKP
Sbjct: 1896 QNVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTS-PPSYDSVTKP 1953

Query: 1982 IVEKHEQEGKDEKAKGK 1998
              EK+EQ+  +++ KGK
Sbjct: 1954 DKEKYEQDRTEKEDKGK 1970


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2969 bits (7697), Expect = 0.0
 Identities = 1531/2019 (75%), Positives = 1717/2019 (85%), Gaps = 72/2019 (3%)

Query: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNP-KPD---KKDDDENGPKPNSDLE 56
            M   +L PPGPDSF  FT ESLA IERRIAE K K P K D   ++DD+++ PKPNSDLE
Sbjct: 1    MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60

Query: 57   AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNP 116
            AGK+LPFIYGDIP  +V+ PLED DPYY+ +KTF+VLN+GK +FRFSAT ALYIL+PFN 
Sbjct: 61   AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120

Query: 117  LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIAR 176
            +R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KIIAR
Sbjct: 121  IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180

Query: 177  GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
            GFC++ FTFLRDPWNWLDF+VI  AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181  GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240

Query: 237  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNI 296
            VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP               
Sbjct: 241  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP--------------- 285

Query: 297  TVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGR 356
             +N+N + +      FDW+ YI +    Y + G L+ LLCGNSSDAGQCPEGY C+KAGR
Sbjct: 286  -INFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGR 344

Query: 357  NPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLIN 416
            NPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+N
Sbjct: 345  NPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVN 404

Query: 417  LILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEHS-- 470
            LILAVVAMAYEEQNQATLEEAEQKEAEF+ M+EQLKKQQE AQ AA AT+    SE +  
Sbjct: 405  LILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIE 464

Query: 471  REPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEK-DEDEFQKSESEDSI 529
             E    G    SSSE SKLSSKSAKERRNRRKKRKQKE S GEEK D ++  KSESED +
Sbjct: 465  EEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGM 524

Query: 530  RRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRG--RAKDVGSE 587
            RRK FR  +  NR+   +++S  +QSLLSI GS F  R NS++S+FSFRG  R +D GSE
Sbjct: 525  RRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSE 580

Query: 588  NDFADDEHSTFEDNESRRDSLFVPRRHGERRNS-----NLSQTSRSSRMLAVFPANGKMH 642
            N+FADDEHST E++E RRDSLF+P R  ERR+S       SQ SRSSR+      + K +
Sbjct: 581  NEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRN 640

Query: 643  STVDCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRA 702
            STVDCNGVVSL+GGP       G+LLPE TT E E++K+   S  VSMD L    ++ R 
Sbjct: 641  STVDCNGVVSLIGGPGSHIG--GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDRI 697

Query: 703  MSIASILTNT-VEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDL 761
             SI S++TNT VEELEES++KCPPCWYKF+N FLIW+C PYW+K+K +VNL+VMDPFVDL
Sbjct: 698  NSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDL 757

Query: 762  AITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGW 821
            AITICIVLNTLFMAMEH+PMT  F +VL VGNLVFTGIFTAEMFLK+IAMDPYYYFQEGW
Sbjct: 758  AITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGW 817

Query: 822  NIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN 881
            NIFDGFIV+LSL+EL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN
Sbjct: 818  NIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN 877

Query: 882  LTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEW 941
            LTLVLAIIVFIFAVVGMQLFGKSYK+CVCKI  DC+LPRWHM+DFFHSFLIVFRVLCGEW
Sbjct: 878  LTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEW 937

Query: 942  IETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNL 1001
            IETMWDCMEVAGQAMCL VFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDD EMNNL
Sbjct: 938  IETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNL 997

Query: 1002 QIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHT-AEIGK 1060
            QI+V R+ KGVA+ K K++ F+Q  F  KQ+  DE+KPLD+L  KK +C++NHT A+I +
Sbjct: 998  QISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHR 1055

Query: 1061 DLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTED 1120
            + D+ K+ NGTTSGIG  SSVEKYIIDE D+MSFINNP+LTV VPIAVGESDFENLNTED
Sbjct: 1056 NGDFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTED 1112

Query: 1121 FSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKC 1180
             SSESD E SK+KL+++SSS EGST+DI   VEE PV +PEE L+P+ACFTEGCVQRFKC
Sbjct: 1113 VSSESDPEGSKDKLDDTSSS-EGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKC 1171

Query: 1181 CQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTM 1240
            CQ+N+EEG GK WW LR+TCF IVEHNWFETFI+FMILLSSGALAFEDIYI+QRKTI+T+
Sbjct: 1172 CQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTI 1231

Query: 1241 LEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA 1300
            LEYADKVFTYIFILEMLLKW AYG+  +FTNAWCWLDFLIV VSLVSL ANALGYSELGA
Sbjct: 1232 LEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGA 1291

Query: 1301 IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360
            IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAG
Sbjct: 1292 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1351

Query: 1361 KFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETA-RWKNVKVNFDNVGFGYLSLLQVAT 1419
            K+++C N T+  RF+IEDVNN T+C KL+E N T  RWKNVK+NFDNVG GYL+LLQVAT
Sbjct: 1352 KYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT 1411

Query: 1420 FKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1479
            FKGWMDIMYAAVDSR  + QPKYE+++YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQK
Sbjct: 1412 FKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1471

Query: 1480 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMIL 1539
            KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+L
Sbjct: 1472 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMML 1531

Query: 1540 ICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV 1599
            ICLNMVTMMVETD QS+ +  IL  INLVF++ FT ECVLK+ +LRHYYFTIGWNIFDFV
Sbjct: 1532 ICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFV 1591

Query: 1600 VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1659
            VVILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL
Sbjct: 1592 VVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1651

Query: 1660 FNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1719
            FNIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1652 FNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1711

Query: 1720 APILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1779
             PILN +PPDC  +K +PGS  KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFS
Sbjct: 1712 LPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFS 1770

Query: 1780 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLI 1839
            VATEESA+PLSEDDFE FYE+WEKFDPDATQF+E+ KL+ FA ALE PL +P+PN ++LI
Sbjct: 1771 VATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELI 1830

Query: 1840 AMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTL 1899
            AMDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSY+PITTTL
Sbjct: 1831 AMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTL 1890

Query: 1900 KRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSIT 1959
            +RKQEEVSAV++QRAYR HL +R       T NK +                  N  +  
Sbjct: 1891 RRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTHR 1932

Query: 1960 EKTDLTMSTAACPPSYDRVTKPIVEKHE--QEGKDEKAK 1996
            EK + T STA+ P SYD VTKP  EK +  +EG+ E+AK
Sbjct: 1933 EKKESTPSTASLP-SYDSVTKPEKEKQQRAEEGRRERAK 1970


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2407 bits (6239), Expect = 0.0
 Identities = 1274/2015 (63%), Positives = 1500/2015 (74%), Gaps = 107/2015 (5%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSES 1125
            +   G   G GT    E                   V VPIAV ESD ++   ED  +  
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDD-QEEDEENSL 1067

Query: 1126 DLEESKEKLNESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQI 1183
              EE   K     S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC +
Sbjct: 1068 GTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1127

Query: 1184 NVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEY 1243
            +  +  GK WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEY
Sbjct: 1128 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1187

Query: 1244 ADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1303
            ADK+FTY+F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1188 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1247

Query: 1304 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1363
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1248 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1307

Query: 1364 HCINTTTGDR-FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKG 1422
             CIN T GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1308 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1366

Query: 1423 WMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1482
            WMDIMYAAVDSR  E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1367 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1426

Query: 1483 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICL 1542
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICL
Sbjct: 1427 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1486

Query: 1543 NMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVI 1602
            NMVTMMVETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI
Sbjct: 1487 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1546

Query: 1603 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1662
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1547 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1606

Query: 1663 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1722
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1607 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1666

Query: 1723 LNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1782
            LN+ PP CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1667 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1725

Query: 1783 EESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMD 1842
            EES EPLSEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MD
Sbjct: 1726 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1785

Query: 1843 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRK 1902
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK
Sbjct: 1786 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1845

Query: 1903 QEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---S 1957
             EEVSA++IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    
Sbjct: 1846 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1905

Query: 1958 ITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKD 1992
            +   +  ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1906 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSD 1940


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2391 bits (6197), Expect = 0.0
 Identities = 1272/2049 (62%), Positives = 1504/2049 (73%), Gaps = 122/2049 (5%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYII--------------DESDYMSFINNPSLTVTVPIAVGES 1111
            +   G   G GT    E   +              DE + +      S   + P++ G  
Sbjct: 1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPE 1086

Query: 1112 ---DFENLNTEDFSSESDLEESKEKLN-----------------ESSSSSEGSTVDIGAP 1151
               D    +    ++ S+ E S  + +                    S SEGST D+   
Sbjct: 1087 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1146

Query: 1152 VE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWF 1209
             E  EQ     ++  +PE CFTEGCV+R  CC ++  +  GK WW LR+TC+ IVEH+WF
Sbjct: 1147 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1206

Query: 1210 ETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYF 1269
            ETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY+F+LEMLLKWVAYG++ YF
Sbjct: 1207 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1266

Query: 1270 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1329
            TNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNAL
Sbjct: 1267 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1326

Query: 1330 LGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGD-RFDIEDVNNHTDCLKL 1388
            +GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T GD   +   VNN + C  L
Sbjct: 1327 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1386

Query: 1389 IERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYM 1448
                E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++E +LYM
Sbjct: 1387 NLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1445

Query: 1449 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1508
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1446 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1505

Query: 1509 QKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLV 1568
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQS     IL++INL+
Sbjct: 1506 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1565

Query: 1569 FIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIR 1628
            F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1566 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1625

Query: 1629 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1688
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E 
Sbjct: 1626 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1685

Query: 1689 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNP 1748
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   N   S +GDCG+P
Sbjct: 1686 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSP 1744

Query: 1749 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1808
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1745 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1804

Query: 1809 TQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1868
            TQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGES
Sbjct: 1805 TQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGES 1864

Query: 1869 GEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQAS 1928
            GEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA++IQRA+RRHLL+R++K AS
Sbjct: 1865 GEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1924

Query: 1929 FTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDLTMSTAACPPSYDRVTKPIV 1983
            F + +    G    +   +E +I   ++EN    +   +  ++S+ + PPSYD VT+   
Sbjct: 1925 FLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATS 1984

Query: 1984 EKHEQEGKD 1992
            +  +  G D
Sbjct: 1985 DNLQVRGSD 1993


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2390 bits (6195), Expect = 0.0
 Identities = 1280/2068 (61%), Positives = 1507/2068 (72%), Gaps = 159/2068 (7%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1117
            +   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1118 TEDFSSE----------------------------SDLEESKEKLN-------------- 1135
            TE+ SS+                            S+ E S  + +              
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1136 ---ESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRG 1190
                  S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC ++  +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTY 1250
            K WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1251 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
            +F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTT 1370
            RPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1371 GD-RFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
            GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYA
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
            AVDSR  E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFM
Sbjct: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1487

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
            TEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMV
Sbjct: 1488 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMV 1547

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF 1609
            ETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  
Sbjct: 1548 ETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV 1607

Query: 1610 LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1669
            L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLV
Sbjct: 1608 LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLV 1667

Query: 1670 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1729
            MFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP 
Sbjct: 1668 MFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1727

Query: 1730 CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL 1789
            CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPL
Sbjct: 1728 CDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPL 1786

Query: 1790 SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD 1849
            SEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGD
Sbjct: 1787 SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGD 1846

Query: 1850 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1909
            RIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA+
Sbjct: 1847 RIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAM 1906

Query: 1910 IIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDL 1964
            +IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    +   +  
Sbjct: 1907 VIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSS 1966

Query: 1965 TMSTAACPPSYDRVTKPIVEKHEQEGKD 1992
            ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1967 SISSTSFPPSYDSVTRATSDNLQVRGSD 1994


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2386 bits (6183), Expect = 0.0
 Identities = 1277/2068 (61%), Positives = 1507/2068 (72%), Gaps = 159/2068 (7%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1117
            +   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1118 TEDFSSE----------------------------SDLEESKEKLN-------------- 1135
            TE+ SS+                            S+ E S  + +              
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1136 ---ESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRG 1190
                  S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC ++  +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTY 1250
            K WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1251 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
            +F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTT 1370
            RPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1371 GDR-FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
            GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYA
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
            AVDSR  E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFM
Sbjct: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1487

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
            TEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMV
Sbjct: 1488 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMV 1547

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF 1609
            ETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  
Sbjct: 1548 ETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV 1607

Query: 1610 LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1669
            L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLV
Sbjct: 1608 LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLV 1667

Query: 1670 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1729
            MFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP 
Sbjct: 1668 MFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1727

Query: 1730 CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL 1789
            CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPL
Sbjct: 1728 CDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPL 1786

Query: 1790 SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD 1849
            SEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGD
Sbjct: 1787 SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGD 1846

Query: 1850 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1909
            RIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA+
Sbjct: 1847 RIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAM 1906

Query: 1910 IIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDL 1964
            +IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    +   +  
Sbjct: 1907 VIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSS 1966

Query: 1965 TMSTAACPPSYDRVTKPIVEKHEQEGKD 1992
            ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1967 SISSTSFPPSYDSVTRATSDNLQVRGSD 1994


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2340 bits (6063), Expect = 0.0
 Identities = 1260/2068 (60%), Positives = 1490/2068 (72%), Gaps = 177/2068 (8%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1117
            +   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1118 TEDFSSE----------------------------SDLEESKEKLN-------------- 1135
            TE+ SS+                            S+ E S  + +              
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1136 ---ESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRG 1190
                  S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC ++  +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTY 1250
            K WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1251 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
            +F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTT 1370
            RPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1371 GDR-FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
            GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQV            
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQV------------ 1415

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
                   E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFM
Sbjct: 1416 ------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1469

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
            TEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMV
Sbjct: 1470 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMV 1529

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF 1609
            ETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  
Sbjct: 1530 ETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV 1589

Query: 1610 LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1669
            L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLV
Sbjct: 1590 LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLV 1649

Query: 1670 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1729
            MFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP 
Sbjct: 1650 MFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1709

Query: 1730 CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL 1789
            CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPL
Sbjct: 1710 CDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPL 1768

Query: 1790 SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD 1849
            SEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGD
Sbjct: 1769 SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGD 1828

Query: 1850 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1909
            RIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA+
Sbjct: 1829 RIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAM 1888

Query: 1910 IIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDL 1964
            +IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    +   +  
Sbjct: 1889 VIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSS 1948

Query: 1965 TMSTAACPPSYDRVTKPIVEKHEQEGKD 1992
            ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1949 SISSTSFPPSYDSVTRATSDNLQVRGSD 1976


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2315 bits (5999), Expect = 0.0
 Identities = 1242/2049 (60%), Positives = 1476/2049 (72%), Gaps = 154/2049 (7%)

Query: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459  ---SSLEMSPLAPVNSHERRSKRRKRM---SSGTEECGEDRLPKSDSEDGPRAM------ 506

Query: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
              N L+  +  S       S RGS+F+ RR             +D+GSE DFADDE+ST 
Sbjct: 507  --NHLSLTRGLSRTSMKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTA 551

Query: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658  SVPTSPVGQLL-------PEGTTTETEM--RKRRSSSFHVSMDFLEDPSQRQRAMSIASI 708
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1066 KDVNGTTSGIGTGSSVEKYII--------------DESDYMSFINNPSLTVTVPIAVGES 1111
            +   G   G GT    E   +              DE + +      S   + P++ G  
Sbjct: 1027 RFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPE 1086

Query: 1112 ---DFENLNTEDFSSESDLEESKEKLN-----------------ESSSSSEGSTVDIGAP 1151
               D    +    ++ S+ E S  + +                    S SEGST D+   
Sbjct: 1087 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1146

Query: 1152 VE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWF 1209
             E  EQ     ++  +PE CFTEGCV+R  CC ++  +  GK WW LR+TC+ IVEH+WF
Sbjct: 1147 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1206

Query: 1210 ETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYF 1269
            ETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY+F+LEMLLKWVAYG++ YF
Sbjct: 1207 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1266

Query: 1270 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1329
            TNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNAL
Sbjct: 1267 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1326

Query: 1330 LGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGD-RFDIEDVNNHTDCLKL 1388
            +GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T GD   +   VNN + C  L
Sbjct: 1327 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1386

Query: 1389 IERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYM 1448
                E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++E +LYM
Sbjct: 1387 NLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1445

Query: 1449 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1508
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1446 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1505

Query: 1509 QKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLV 1568
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQS     IL++INL+
Sbjct: 1506 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1565

Query: 1569 FIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIR 1628
            F+ +FT                                G  L+++I+KYF SPTLFRVIR
Sbjct: 1566 FVAIFT--------------------------------GTVLSDIIQKYFFSPTLFRVIR 1593

Query: 1629 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1688
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E 
Sbjct: 1594 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1653

Query: 1689 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNP 1748
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   N   S +GDCG+P
Sbjct: 1654 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSP 1712

Query: 1749 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1808
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1713 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1772

Query: 1809 TQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1868
            TQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGES
Sbjct: 1773 TQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGES 1832

Query: 1869 GEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQAS 1928
            GEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA++IQRA+RRHLL+R++K AS
Sbjct: 1833 GEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1892

Query: 1929 FTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDLTMSTAACPPSYDRVTKPIV 1983
            F + +    G    +   +E +I   ++EN    +   +  ++S+ + PPSYD VT+   
Sbjct: 1893 FLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATS 1952

Query: 1984 EKHEQEGKD 1992
            +  +  G D
Sbjct: 1953 DNLQVRGSD 1961


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2097 bits (5432), Expect = 0.0
 Identities = 1135/2040 (55%), Positives = 1408/2040 (69%), Gaps = 185/2040 (9%)

Query: 12   DSFNFFTRESLAAIERRIAEE----KAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGD 67
            ++F  FT ESL  IE++IA +    KA+    ++KD +E  P+P  DL+A   LP  YG+
Sbjct: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEK-PRPQLDLKACNQLPKFYGE 69

Query: 68   IPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVH 127
            +P E++ EPLEDLDP+Y   +TF+VLNKG+ I RFSAT AL++ +PFN +R+ AIK+ VH
Sbjct: 70   LPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVH 129

Query: 128  SLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLR 187
            S FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKI+ARGFCL +FT+LR
Sbjct: 130  SWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLR 186

Query: 188  DPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKL 247
            DPWNWLDF+VIT AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL
Sbjct: 187  DPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKL 246

Query: 248  SDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINE 307
            +DV ILT+FCLSVFAL+GLQLF GNL+NKC++                     N   +NE
Sbjct: 247  ADVTILTIFCLSVFALVGLQLFKGNLKNKCVK---------------------NDMAVNE 285

Query: 308  TVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDT 367
            T    ++ S+ +   Y     G  D LLCGN SD+G CP+GY+C+K   NP++ YTSFD+
Sbjct: 286  TT---NYSSHRKPDIY-INKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341

Query: 368  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 427
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401

Query: 428  EQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEAS 487
            EQNQAT +E E KE +FQ+ +E L+K+QE        T S HS                S
Sbjct: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHN-------------GS 448

Query: 488  KLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEK 547
             L+SK+A ERR+R K R     S G  +D     KS   D                    
Sbjct: 449  PLTSKNASERRHRIKPRV----SEGSTEDN----KSPRSDPY------------------ 482

Query: 548  RYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFE-DNESRRD 606
                 +Q  +S  G     RR S  S+F FR   +D+       DD    F  D+ES R 
Sbjct: 483  -----NQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHRG 535

Query: 607  SLFVPRRHGERR---NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSP 663
            SL +    G++     S L Q S                         S  G       P
Sbjct: 536  SLLLGGGAGQQGPLPRSPLPQPSNPD----------------------SRHGEDEHQPPP 573

Query: 664  VGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKC 723
              +L P G    +     +  +F +S ++L++P + QRAMS+ SI+T+ +EELEES QKC
Sbjct: 574  TSELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKC 631

Query: 724  PPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTD 783
            PPC    S  +LIWDC P W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+ 
Sbjct: 632  PPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP 691

Query: 784  HFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
             F  +L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IVT+SL+ELG+A    
Sbjct: 692  TFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGS 751

Query: 844  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903
            LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G+
Sbjct: 752  LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGE 811

Query: 904  SYKDCVCKIASDCQ-LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFM 962
            +Y++    I++  +  PRWHM+DFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+
Sbjct: 812  NYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFL 871

Query: 963  MVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEF 1022
             VMV+GNLVVLNLF+ALLL+SFSADNL A +DD E+NNLQ+A+ R+       K+ +  F
Sbjct: 872  TVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF 931

Query: 1023 IQQSF-IRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSV 1081
              +S    + K   E+     L++ K     NH A              T  G   G   
Sbjct: 932  FSRSCPFPQPKAEPELVVKLPLSSSK---AENHIAA------------NTARGSSGGLQA 976

Query: 1082 EKYIIDESDYMSFINNPSLTVTVPIAVGESDFENL------NTEDFSSESDLEESKEKLN 1135
             +   DE  +  FI NP++ V+VPIA GESD ++L      + + F  E   +  +E+L 
Sbjct: 977  PRGPRDE--HSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQ 1034

Query: 1136 --------------------------------------------ESSSSSEGSTVDIGAP 1151
                                                        + +SSSEGSTVD   P
Sbjct: 1035 QVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDP 1094

Query: 1152 VE-EQPVVEPEETL-EPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWF 1209
             E  + + E  + L EP+ CFTEGC++   CC+++  +      W +R+TC+RIVEH+WF
Sbjct: 1095 EEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWF 1154

Query: 1210 ETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYF 1269
            E+FI+FMILLSSG+LAFED Y+DQ+ T+K +LEY D+VFT+IF+ EMLLKWVAYG++ YF
Sbjct: 1155 ESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYF 1214

Query: 1270 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1329
            TNAWCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL
Sbjct: 1215 TNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDAL 1274

Query: 1330 LGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGD--RFDIEDVNNHTDCLK 1387
            +GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CIN T G+     +  VNN +DC K
Sbjct: 1275 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDC-K 1333

Query: 1388 LIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLY 1447
            +     +  W NVKVNFDNV  GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+E+++Y
Sbjct: 1334 IQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVY 1393

Query: 1448 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507
            MYLYFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKK
Sbjct: 1394 MYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1453

Query: 1508 PQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINL 1567
            PQKPIPRP NKFQG VFD VTRQ FDI+IM+LICLNM+TMMVETDDQSE  T IL +IN 
Sbjct: 1454 PQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQ 1513

Query: 1568 VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFR 1625
             F+ +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFR
Sbjct: 1514 FFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFR 1573

Query: 1626 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1685
            VIRLARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+
Sbjct: 1574 VIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVR 1633

Query: 1686 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDC 1745
             E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDPN  N  +  +GDC
Sbjct: 1634 WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDC 1692

Query: 1746 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1805
            G+P+VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFD
Sbjct: 1693 GSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFD 1752

Query: 1806 PDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1865
            P+ATQF+ F  LS FA  L  PL +P+PN+  LI MDLP+V GD+IHCLDILFAFTK VL
Sbjct: 1753 PEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVL 1812

Query: 1866 GESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVK 1925
            GESGE+D+L+  MEE+FMA+N SK SY+PI TTL+ KQE++SA +IQ+AYR ++L R++ 
Sbjct: 1813 GESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSM- 1871

Query: 1926 QASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEK 1985
              S T    + +  A  L  E  +    NEN +      T S  + PPSY+ VT+ + ++
Sbjct: 1872 ALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDR 1931


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1846 bits (4781), Expect = 0.0
 Identities = 920/1253 (73%), Positives = 1058/1253 (84%), Gaps = 10/1253 (0%)

Query: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768
            +++ +EELEE+ QKCPP WYK ++  LIW+C   WLK K++++L+VMDPFVDL ITICIV
Sbjct: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589

Query: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828
            LNTLFMAMEHYPMT+HF+NVLTVGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649

Query: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888
            VTLSLVELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709

Query: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948
            IVFIFAVVGMQLFGKSYK+CVCKIA DC LPRWHM+DFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769

Query: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008
            MEVAGQAMCLTVF+MVMVIGNLVVLNLFLALLLSSFSAD+LAA+D+D EMNNLQIA+ R+
Sbjct: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829

Query: 1009 HKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDY-LKD 1067
              G+ + K  +   +    +  + I+  +   D      ++  +    E  +  +  LK 
Sbjct: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889

Query: 1068 VNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDL 1127
             N   + +G        +  E D+++FINNP LT+ VPIA  ESD E    E+  + S+ 
Sbjct: 890  DNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEP 947

Query: 1128 EESKEKLNE--SSSSSEGSTVDIGAPVEEQPVVEPEETLE---PEACFTEGCVQRFKCCQ 1182
            E+SK+        +SS  ST D   P EE P  + EE  E   PE CFTE CVQR+ C  
Sbjct: 948  EDSKKPPQPLYDGNSSVCSTADYKPP-EEDPEEQAEENPEGEQPEECFTEACVQRWPCLY 1006

Query: 1183 INVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLE 1242
            +++ +GRGK+WW LRR CF+IVEHNWFETFIVFMILLSSGALAFEDIYI+QR+ I+T+LE
Sbjct: 1007 VDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILE 1066

Query: 1243 YADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIK 1302
            YADKVFTYIFI+EMLLKWVAYG++ YFTNAWCWLDFLIVDVS++SL AN LGYSELG IK
Sbjct: 1067 YADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIK 1126

Query: 1303 SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1362
            SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1127 SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1186

Query: 1363 YHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKG 1422
            Y+CINTTT +RFDI +VNN ++C  L+   +  RW NVKVN+DNVG GYLSLLQVATFKG
Sbjct: 1187 YYCINTTTSERFDISEVNNKSECESLMHTGQV-RWLNVKVNYDNVGLGYLSLLQVATFKG 1245

Query: 1423 WMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1482
            WMDIMYAAVDSR  E QP+YE +LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1246 WMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1305

Query: 1483 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICL 1542
            GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VT+Q FDI+IMILICL
Sbjct: 1306 GGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICL 1365

Query: 1543 NMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVI 1602
            NMVTMMVETD+QS+    IL  IN++FI++FTGECVLK+++LR YYFT+GWNIFDFVVVI
Sbjct: 1366 NMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVI 1425

Query: 1603 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1662
            LSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1426 LSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNI 1485

Query: 1663 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1722
            GLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGLL PI
Sbjct: 1486 GLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPI 1545

Query: 1723 LNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1782
            LNS PPDCDPN  NPG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF+VAT
Sbjct: 1546 LNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVAT 1605

Query: 1783 EESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMD 1842
            EES+EPL EDDFEMFYE WEKFDPDATQF+ + +LS F   L+ PL + +PNK++LI +D
Sbjct: 1606 EESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLD 1665

Query: 1843 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRK 1902
            LPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSY+PITTTLKRK
Sbjct: 1666 LPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRK 1725

Query: 1903 QEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINE 1955
             EEV A+ IQRAYRRHLL+R++KQAS+ Y  +    G +   KE ++ + +++
Sbjct: 1726 HEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778



 Score =  674 bits (1738), Expect = 0.0
 Identities = 343/487 (70%), Positives = 393/487 (80%), Gaps = 27/487 (5%)

Query: 6   LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIY 65
           LVP GP+    FTRESLAAIE+R  EE+A+  +  + + +E   KP SDLEAGKNLP IY
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68

Query: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKIL 125
           GD PPE++  PLEDLDPYY NKKTFIVLNKGKAIFRFSAT ALY+L+PF+ +R+ AIK+L
Sbjct: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128

Query: 126 VHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185
           +H+LFSM IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKI+ARGFC++DFTF
Sbjct: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188

Query: 186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245
           LRDPWNWLDF+VI  AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248

Query: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP----TNASLEEH----------- 290
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP    TN +   +           
Sbjct: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYG 308

Query: 291 --------SIEKNITVNYNGT-LINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSD 341
                   S   N T N + +   N+T   FDW +YI D    YFLEG  DALLCGNSSD
Sbjct: 309 NEMWYGNDSWYANDTWNSHASWATNDT---FDWDAYISDEGNFYFLEGSNDALLCGNSSD 365

Query: 342 AGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI 401
           AG CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMI
Sbjct: 366 AGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI 425

Query: 402 FFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQA 461
           FFV++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQM+E+ KK QE  ++A
Sbjct: 426 FFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKA 485

Query: 462 ATATASE 468
             A A E
Sbjct: 486 KAAQALE 492



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 79/340 (23%), Positives = 141/340 (41%), Gaps = 81/340 (23%)

Query: 117  LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 168
            LR+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 169  SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 222
             L+K +A GF +    +  + W WLDF ++  + ++       + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP 282
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187

Query: 283  TNASLEEHSIEKNITVNYNGTLINETVFE-FDWKSYIQDSRYHYFLEGFLDALLCGNSSD 341
                                  IN T  E FD       S              C +   
Sbjct: 1188 --------------------YCINTTTSERFDISEVNNKSE-------------CESLMH 1214

Query: 342  AGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 397
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 1215 TGQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263

Query: 398  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 75/378 (19%), Positives = 155/378 (41%), Gaps = 55/378 (14%)

Query: 1109 GESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEA 1168
            GE+D +  + +D +   D  + ++     SSS +    D    +E     E  +   P  
Sbjct: 494  GEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELE-----EAHQKCPPWW 548

Query: 1169 CFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFED 1228
                  V  + CC           W   +     IV   + +  I   I+L++  +A E 
Sbjct: 549  YKCAHKVLIWNCC---------APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAME- 598

Query: 1229 IYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSL 1288
             +    +    +L   + VFT IF  EM+LK +A     YF   W   D +IV +SLV  
Sbjct: 599  -HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVE- 656

Query: 1289 TANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1348
                LG + +  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   
Sbjct: 657  ----LGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 712

Query: 1349 IFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVG 1408
            IF+++G+ LF   +  C+                  C   ++ N   RW     +  +  
Sbjct: 713  IFAVVGMQLFGKSYKECV------------------CKIALDCN-LPRW-----HMHDFF 748

Query: 1409 FGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFI 1468
              +L + ++   + W++ M+  ++           +++ + ++ ++ +I G+   LNLF+
Sbjct: 749  HSFLIVFRILCGE-WIETMWDCMEVAG--------QAMCLTVFLMVMVI-GNLVVLNLFL 798

Query: 1469 GVIIDNFNQQKKKFGGQD 1486
             +++ +F+        +D
Sbjct: 799  ALLLSSFSADSLAASDED 816



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 86/169 (50%), Gaps = 18/169 (10%)

Query: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
            +RR   +++ H  F  FI+  IL +   +   D            +EY    FT I+  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-----PPPWSKNVEYT---FTGIYTFE 171

Query: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
             L+K +A G+     T+  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 51/187 (27%), Positives = 95/187 (50%), Gaps = 13/187 (6%)

Query: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
           ++FS    ++  SP+ +  +  + +++   F  + I I I+ N +FM M   P      N
Sbjct: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPPPWS--KN 159

Query: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
           V       FTGI+T E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  
Sbjct: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGN 214

Query: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902
           +S LR+FR+LR  K     P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G
Sbjct: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274

Query: 903 KSYKDCV 909
              + CV
Sbjct: 275 NLRQKCV 281



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 50/175 (28%), Positives = 88/175 (50%), Gaps = 16/175 (9%)

Query: 113 PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 166
           P+   + I   I++     + I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622

Query: 167 FESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV---SALRTFRVLRA 223
            E ++K+IA    ++ + + +  WN  D  ++T + V   + L NV   S LR+FR+LR 
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRV 676

Query: 224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCI 278
            K     P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 29/155 (18%), Positives = 65/155 (41%), Gaps = 18/155 (11%)

Query: 926  FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985
            F  +FL +FR++  ++ E ++     A     +  F++++ +G+  ++NL LA++  +++
Sbjct: 392  FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451

Query: 986  ADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNN 1045
              N A   +D E                  K + ++ + + F + Q+ L++ K    L  
Sbjct: 452  EQNEATLAEDKE------------------KEEEFQQMLEKFKKHQEELEKAKAAQALEG 493

Query: 1046 KKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSS 1080
             +      H  +    LD  +   G      +G S
Sbjct: 494  GEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDS 528


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1303 bits (3373), Expect = 0.0
 Identities = 677/1296 (52%), Positives = 904/1296 (69%), Gaps = 47/1296 (3%)

Query: 665  GQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCP 724
            G    E  T + EM+KR   S   S+D LED + R +            EELE+S++ CP
Sbjct: 425  GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472

Query: 725  PCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 784
              WYKF+  FLIW+CSP WLK+K  V+ ++M PF DL + ICI+LN  F+ +EHYPM+  
Sbjct: 473  LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532

Query: 785  FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGL 844
             N +L +GNLVF GIFTAEM  KIIAM PY YFQ GWNIFD  IV   L+EL LANV G+
Sbjct: 533  TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592

Query: 845  SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 904
            ++LR FR+LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LFGK+
Sbjct: 593  ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652

Query: 905  YKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMV 964
            Y++ VC I  DCQLPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+  ++MV
Sbjct: 653  YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712

Query: 965  MVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQ 1024
            ++IGNL+VL LFLAL+ SSFS+      +++NE  NLQ+AV R+ KG+ YV  KI     
Sbjct: 713  ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKI----- 766

Query: 1025 QSFIRKQKI-LDEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGTGSSVE 1082
                + Q +  D +  ++++  K+D  +S+HT +E+    D+LKD   ++   GT  +  
Sbjct: 767  --LCKTQNVPKDTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKSS---GTEKNAT 819

Query: 1083 KYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSE 1142
                 E++  S I +PS++ TVPIA GESD ENL+ ++  S+S    SKEK+ +SSSS E
Sbjct: 820  -----ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSS-E 873

Query: 1143 GSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1202
             STVDI    EE+     E +         GC +     QI+    +GK W N+R+TC +
Sbjct: 874  CSTVDIAISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCK 929

Query: 1203 IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVA 1262
            IVE+NWF+ FI  + LLS+G LAFEDIY+DQRKTIK +LEYAD +FTYIFILEMLLKW+A
Sbjct: 930  IVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMA 989

Query: 1263 YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGM 1322
            YG++ YF+N W  LDF++V V  +SL            +K L +++ LRPLR LS+FE M
Sbjct: 990  YGFKAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERM 1044

Query: 1323 RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNH 1382
            +VVV AL+      +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+G+RF   +V N 
Sbjct: 1045 KVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNK 1104

Query: 1383 TDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1442
            + C  L+  NE+  W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS  V +QP +
Sbjct: 1105 SRCESLLF-NESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHF 1163

Query: 1443 EESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1502
            E ++YMY YF+ FIIFG F  L++ I VIIDNFN+ K K GG +IF+T +Q+K Y  +KK
Sbjct: 1164 EVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKK 1223

Query: 1503 LGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTIL 1562
            L  +  Q+P+PRP NK QG +FD VT Q F++ +M+LIC   + MM++TD QS  ++  L
Sbjct: 1224 LMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIAL 1283

Query: 1563 SRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1622
              IN +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L   +  Y V P+
Sbjct: 1284 YWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPS 1343

Query: 1623 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1682
            L ++I L+RI  +LRL KG K    L+  LM+SLPAL NI LL+FLVMFIYA+FGM NFA
Sbjct: 1344 LVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFA 1403

Query: 1683 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVK 1742
            YVK+E GI+D+ NFETFGNSM+CLFQ+   AGWDG+L  I NSK  DCDP+K+NPG+ V+
Sbjct: 1404 YVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVR 1463

Query: 1743 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1802
            GDCGNPSVGIF+FVSYI+IS+L++VNMYI V++E  ++A+++  + LSEDDF  F++VW+
Sbjct: 1464 GDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWK 1523

Query: 1803 KFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTK 1862
            +FDPD TQ+++  KLS FAAAL+PPL + +PNK QLIA+DLPM  GDRIHCLDIL AFTK
Sbjct: 1524 RFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTK 1583

Query: 1863 RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKR 1922
            RV+G+   M+ +  ++E  F+ +NP K++ +PITTTLKRKQE VSA IIQRAY+ + L+R
Sbjct: 1584 RVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRR 1643

Query: 1923 TVKQASFTYNKNKIKGGANL-LIKEDMIIDRINENS 1957
              K  S   + + I G  ++   KE    D+  E S
Sbjct: 1644 NDKNTS---DIHMIDGDRDVHATKEGAYFDKAKEKS 1676



 Score =  424 bits (1090), Expect = e-118
 Identities = 232/500 (46%), Positives = 314/500 (62%), Gaps = 32/500 (6%)

Query: 5   VLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFI 64
           +L  P P     FT+ES   I++ IA       K   +D +E   KP  DLE GK LPFI
Sbjct: 1   MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53

Query: 65  YGDIPPEMVSEPLEDLDPYYINKK-TFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIK 123
           YG++   MVSEPLED+DPYY  KK TFIVLNK + IFRF+A S L  L+PFN +R+  IK
Sbjct: 54  YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113

Query: 124 ILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDF 183
           +LVH  F + I+ ++L +CVFM+++N P W   +E T  GIYTFE L+K+ ARG     F
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173

Query: 184 TFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
           +FL DPWNWLDF+V  F  +  +  L  +  L+T R LR LK I +  GLK++VG LI  
Sbjct: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGT 303
           +K+L  V+ILT+F LS+F+LIG+ LFMGNL++KC +WP  N                N T
Sbjct: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE---------------NET 278

Query: 304 LINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYT 363
           L N T   +    YI+++   Y+LEG   ALLCGN +DAGQCPEGY+CVKAG NP+ G+T
Sbjct: 279 LHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT 334

Query: 364 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
           +FD+F WA  +LFRLM QD+ E LY   L A+GK YMIFFV+V FL SFY+ +L L ++A
Sbjct: 335 NFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILA 394

Query: 424 MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSS 483
           MAYEE+ Q   E +++ E +FQQ  ++L++  E   +A T       R P +    +D+S
Sbjct: 395 MAYEEEKQRVGEISKKIEPKFQQTGKELQEGNE-TDEAKTIQIEMKKRSPIS----TDTS 449

Query: 484 SEASKLSSKSAKERRNRRKK 503
            +  + ++   KE   + KK
Sbjct: 450 LDVLEDATLRHKEELEKSKK 469



 Score =  145 bits (367), Expect = 3e-34
 Identities = 157/688 (22%), Positives = 298/688 (43%), Gaps = 142/688 (20%)

Query: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
            +RRT  +++ H +F+ FI+  +L+    ++  ++   +     T+L     ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162

Query: 1256 MLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1315
            +  + V  G  ++  + W WLDF +    ++      + YS L  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1316 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1364
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G   H           
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276

Query: 1365 -CINTTTGDRFDIEDVNN----HTDCLKLIERNETARWKNVK---------------VNF 1404
              ++  TG+ + I +  N      +   L+  N T   +  +                NF
Sbjct: 277  ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336

Query: 1405 DNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTL 1464
            D+ G+   +L ++   + + +++Y          Q  Y       ++FV+     SF+  
Sbjct: 337  DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386

Query: 1465 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1505
            +LF+G++   + ++K++ G                 Q+   T+E K     MKK      
Sbjct: 387  SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446

Query: 1506 ------------------KKPQKPIPRPGNKFQGMVF------------DFVTRQVF--- 1532
                              +K +K  P    KF                 +FV R +    
Sbjct: 447  DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506

Query: 1533 -DISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHY-YFT 1590
             D+ ++I I LN+  + +E    S+   T+L+  NLVFI +FT E + K+I++  Y YF 
Sbjct: 507  TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566

Query: 1591 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1650
            +GWNIFD ++V   ++ + LA +            ++RL R+ RI +L K     + L++
Sbjct: 567  VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618

Query: 1651 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1703
            +L  S  AL ++ LLLF  +F  A FGM  F   Y +    ID       ++   F +S 
Sbjct: 619  SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678

Query: 1704 ICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISF 1763
            + +F+I      + L          DC             +    S  I F++  I+I  
Sbjct: 679  LNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIGN 717

Query: 1764 LVVVNMYIAVILENFSVATEESAEPLSE 1791
            L+V+ +++A++  +FS   + +AE  +E
Sbjct: 718  LLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 52/198 (26%), Positives = 87/198 (43%), Gaps = 28/198 (14%)

Query: 83  YYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNC 142
           +Y   KTF++ N      +        I+ PF  L               LI+C IL  C
Sbjct: 475 WYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL--------------FLIICIILNVC 520

Query: 143 VFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFT 196
            F+T+ + P     +   N+    F GI+T E + KIIA    +  + + +  WN  D +
Sbjct: 521 -FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-S 574

Query: 197 VITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILT 254
           +I F  + E    ++  ++ LR FR+LR  K     P  + ++ +L  S   L D+++L 
Sbjct: 575 MIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634

Query: 255 VFCLSVFALIGLQLFMGN 272
              +   A  G++LF  N
Sbjct: 635 FTFIFFSAAFGMKLFGKN 652



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 41/178 (23%), Positives = 89/178 (50%), Gaps = 12/178 (6%)

Query: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
           ++F+   ++   SP+   ++     V++ PF  L I I ++++ +FM++ + P    +  
Sbjct: 90  FRFNAASILCTLSPFNC-IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPK---WRP 145

Query: 788 VLTVGNLVFTGIFTAEMFLKIIAMD----PYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
           VL        GI+T E+ +K+ A       + +  + WN  D F VT+  V +  + ++ 
Sbjct: 146 VL---ENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDF 201

Query: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           +  L++ R LR+ K+      L  L+ ++ + +  L  + ++    + IF+++GM LF
Sbjct: 202 IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 13/164 (7%)

Query: 117  LRKIAIKILVHSLFSMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 168
            +RK   KI+ ++ F   I + T+L+           D  K +    EY    FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 169  SLIKIIARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 227
             L+K +A GF      +  + W  LDF V I F           +  L + + LR L+ +
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038

Query: 228  SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            S    +K +V ALI++     +V ++ +    +F+++G+ LF G
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 36/153 (23%), Positives = 71/153 (46%), Gaps = 7/153 (4%)

Query: 368 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVAMAY 426
           F  +FL++FR++  ++ E L+   +  AG+++ I F+++VI +G+  ++ L LA+V+ ++
Sbjct: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731

Query: 427 EEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEA 486
                 T EE  + +   Q  + ++KK              +    P       +     
Sbjct: 732 SSCKDVTAEENNEAK-NLQLAVARIKK---GINYVLLKILCKTQNVPKDTMDHVNEVYVK 787

Query: 487 SKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDE 519
             +S  +  E  N +   K KE+S G EK+  E
Sbjct: 788 EDISDHTLSELSNTQDFLKDKEKSSGTEKNATE 820


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1278 bits (3307), Expect = 0.0
 Identities = 683/1306 (52%), Positives = 908/1306 (69%), Gaps = 75/1306 (5%)

Query: 665  GQLLPEGTTTETEMRKR-------RSSSFHVSMDFLE---DPSQRQRAMSIASILTNTVE 714
            G+  P G+ ++ + +K+       +  S ++S+D  +   DP QRQRA+S  SILT T++
Sbjct: 475  GKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMK 534

Query: 715  ELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFM 774
            E E+S++ C PC    ++ +L+W+C P WL VK V+  V+ DPF +LAITICI++NT+F+
Sbjct: 535  EQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFL 594

Query: 775  AMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLV 834
            AMEH+ M   F  +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD  +  LS  
Sbjct: 595  AMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFA 654

Query: 835  ELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 892
            ++    ++  S   LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++FI
Sbjct: 655  DVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFI 714

Query: 893  FAVVGMQLFGKSY------KDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMW 946
            F+VVGMQLFG+S+      K C     +   L  WHM DF+HSFL+VFR+LCGEWIE MW
Sbjct: 715  FSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMW 774

Query: 947  DCMEVAG--QAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAAT-DDDNEMNNLQI 1003
            +CM+ A    ++C+ VF+++ VIG LVVLNLF+ALLL+SFS +      + +     +Q+
Sbjct: 775  ECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL 834

Query: 1004 AVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMS-----NHTAEI 1058
            A+DR  +   +V+  +  F  + + RKQ +  + +       +    +         +E 
Sbjct: 835  ALDRFRRAFCFVRHTLEHFCHK-WCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSET 893

Query: 1059 GKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLT-VTVPIAVGESDFENLN 1117
             ++L  L  V  T  G+    +    + +E D + F    +   +T P    E     L+
Sbjct: 894  QEELGILTSVPKTL-GVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEP--EQQAYELH 950

Query: 1118 TE--------------DFSSESD----LEESKEKLNESSSSSEGSTVDIGAPVEEQPVVE 1159
             E              D  SE +    +++ ++K + +S  SE ST+D+       P + 
Sbjct: 951  QENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMV 1010

Query: 1160 PEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILL 1219
            P++  +PE C  +G    F CC ++  +     WWNLR+TC++IV+H+WFE+FI+F+ILL
Sbjct: 1011 PKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILL 1068

Query: 1220 SSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFL 1279
            SSGAL FED++++ +  I+ +L   D +FT+IFILEM+LKWVA+G+  YFT+AWC LDF+
Sbjct: 1069 SSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFI 1128

Query: 1280 IVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1339
            IV VS+ +L         L  +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NV
Sbjct: 1129 IVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNV 1181

Query: 1340 LLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKN 1399
            LLVCLIFWL+F I+GV  F+GKF  CIN T     +   + N + C      +    W N
Sbjct: 1182 LLVCLIFWLVFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQC-----ESGNFSWIN 1235

Query: 1400 VKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFG 1459
             KVNFDNVG  YL+LLQVATFKGWMDI+YAAVDS   E QP++E +   Y+YFV+FIIFG
Sbjct: 1236 QKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFG 1295

Query: 1460 SFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKF 1519
            SFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK 
Sbjct: 1296 SFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKC 1355

Query: 1520 QGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVL 1579
            QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + + +IL  +N VF+V+FT EC++
Sbjct: 1356 QGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLI 1415

Query: 1580 KLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRVIRLARIGRILR 1637
            K+ +LR YYFT GWN+FD VVV+LSIV   ++ L  +  +   PTLFR++RLARIGRILR
Sbjct: 1416 KIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILR 1475

Query: 1638 LIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFE 1697
            L++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V  E GIDD+FNF+
Sbjct: 1476 LVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFK 1535

Query: 1698 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVS 1757
            TF +SM+CLFQI+TSAGWD LL+P+L SK   C+ +  N        C  P +   +FVS
Sbjct: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSK-ESCNSSSEN--------CHLPGIATSYFVS 1586

Query: 1758 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKL 1817
            YIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQF+++  L
Sbjct: 1587 YIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSAL 1646

Query: 1818 SQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQ 1877
            S FA AL  PL + +PNK Q + MDLPMVS DR+HC+DILFAFT RVLG S  +D+++  
Sbjct: 1647 SDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAM 1706

Query: 1878 MEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRT 1923
            MEE+FM +NP K  Y+PI TT KRK+EE  A IIQ+A+R++++K T
Sbjct: 1707 MEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVT 1752



 Score =  413 bits (1061), Expect = e-114
 Identities = 248/548 (45%), Positives = 318/548 (58%), Gaps = 69/548 (12%)

Query: 11  PDSFNF--FTRESLAAIERRIAEEKAKNPKPDKKDDDENG----PKPNSDLEAGKNLPFI 64
           PD  NF  FT +SLAAIE+RIA +K K     KK  D+ G    P+P  DL+A + LP +
Sbjct: 11  PDERNFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKL 65

Query: 65  YGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKI 124
           YGDIP E++ +PLEDLDP+Y N KTF+VLN+ + I+RFSA  AL+I  PFN +R +AI++
Sbjct: 66  YGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRV 125

Query: 125 LVHSLFSMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKIIARGFCL 180
            VHSLFSM I+ T++ NCVFM      +   N     E  FTGIY FE+LIKI+ARGF L
Sbjct: 126 SVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFIL 185

Query: 181 EDFTFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGA 239
           ++F+FLRDPWNWLD  VI  A V+    +   +  LRTFRV RALK ISV+  LK IVGA
Sbjct: 186 DEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGA 245

Query: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEE---HSIEKNI 296
           L++SVKKL +V+ILT FCLS+FAL+G QLFMG+L  KCI     N S  E   H  EK  
Sbjct: 246 LLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKK- 304

Query: 297 TVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGR 356
                                          E   +  +CG       C   Y C     
Sbjct: 305 -------------------------------ENSPEFKMCGIWMGNSACSIQYECKHTKI 333

Query: 357 NPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLIN 416
           NP+Y YT+FD F W+FL++FRLMTQD WE LYQ TLR  G   + FF++VIFLGSFYLIN
Sbjct: 334 NPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLIN 393

Query: 417 LILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAA 476
           L LAVV MAYEEQN+    E E KE  FQ+  + LK+++EA                   
Sbjct: 394 LTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEAL-------------VAMGI 440

Query: 477 GRLSDSSSEASKLSSKSAKERRNRRKK-----RKQKEQSGGEEKDEDEFQKSESEDSIRR 531
            R S +S E S  + K  K   N+++K        K+Q  G + DED  +K +  +  +R
Sbjct: 441 DRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKR 500

Query: 532 KGFRFSIE 539
                S++
Sbjct: 501 LSQNLSLD 508



 Score =  100 bits (248), Expect = 2e-20
 Identities = 79/341 (23%), Positives = 154/341 (45%), Gaps = 53/341 (15%)

Query: 1195 NLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFIL 1254
            ++R    R+  H+ F  FI+  ++++   +A        + +     + A+ VFT I+I 
Sbjct: 117  SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172

Query: 1255 EMLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
            E L+K +A G+     ++  + W WLD +++ +++VS             +  LRT R  
Sbjct: 173  EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227

Query: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINTT 1369
            R L+A+S    ++V+V ALL ++  ++NV+++      IF+++G  LF G     CI+  
Sbjct: 228  RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISR- 286

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETAR----W------------KNVKV-------NFDN 1406
              D  +I +   +  C +  E +   +    W            K+ K+       NFDN
Sbjct: 287  --DCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDN 344

Query: 1407 VGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNL 1466
             G+ +L++ ++ T   W            +  Q      LY   +F++ I  GSF+ +NL
Sbjct: 345  FGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINL 394

Query: 1467 FIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507
             + V+   + +Q K    +   +  ++K +  A + L  +K
Sbjct: 395  TLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 79/337 (23%), Positives = 138/337 (40%), Gaps = 87/337 (25%)

Query: 117  LRKIAIKILVHSLFSMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 168
            LRK   +I+ HS F   I+  IL +    +F  + + N P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 169  SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 228
             ++K +A GF      +    W  LDF +I    VT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159

Query: 229  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLE 288
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KCI          
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208

Query: 289  EHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEG 348
                      N   ++IN T+                              ++  QC  G
Sbjct: 1209 ----------NGTDSVINYTII-----------------------------TNKSQCESG 1229

Query: 349  YMCVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM---- 400
                      N+ +     +FD    A+L+L ++ T   W ++    + +  K       
Sbjct: 1230 ----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFE 1279

Query: 401  ------IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431
                  I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1280 SNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 67/310 (21%), Positives = 132/310 (42%), Gaps = 52/310 (16%)

Query: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
           Y+FS    ++   P+   ++ +   V +     + I   +++N +FMA    P  +  +N
Sbjct: 101 YRFSAKHALFIFGPF-NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSN 157

Query: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
              +   VFTGI+  E  +KI+A    +D + + ++ WN  D  ++ +++V         
Sbjct: 158 NTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK 217

Query: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903
           L  LR+FR+ R  K       L +++  +  SV  L N+ ++    + IFA+VG QLF  
Sbjct: 218 LLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277

Query: 904 SY------KDC--------------------------------VCKIASDCQLPR----- 920
           S       +DC                                 C I  +C+  +     
Sbjct: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337

Query: 921 --WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLA 978
              + ++F  SFL +FR++  +  E ++           +  F++V+ +G+  ++NL LA
Sbjct: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 979 LLLSSFSADN 988
           ++  ++   N
Sbjct: 398 VVTMAYEEQN 407



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 46/162 (28%), Positives = 78/162 (48%), Gaps = 13/162 (8%)

Query: 117 LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 170
           ++K+   ++      + I   I+ N VF+ M +       +   N+    FT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 171 IKIIARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 227
           +KIIA    L+ + + R  WN  D  V  ++FA V   V    +   LR+FRVLR  K  
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681

Query: 228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
              P L T++  +  SV  L  + ++ V  + +F+++G+QLF
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 43/174 (24%), Positives = 81/174 (46%), Gaps = 22/174 (12%)

Query: 113  PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMS--NPPDWTKNV----EYTFTGIYT 166
            P N  + +   I+   +F ++I+  I+ N + M     N P   K++     + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 167  FESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN----------VSAL 215
             E LIKI    F L  + F  + WN  D  V+  + V+  +  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 216  RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 69/368 (18%), Positives = 134/368 (36%), Gaps = 97/368 (26%)

Query: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1574
            P N  + +        +F + I+  + +N V M       S    T ++    VF  ++ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1575 GECVLKLIS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1629
             E ++K+++    L  + F    WN  D +V+ ++IV       I+           +R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223

Query: 1630 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1683
             R+ R L+ I     ++ ++ AL+ S+  L N+ +L F  + I+A+ G        N   
Sbjct: 224  FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283

Query: 1684 VKREV-------GIDDMF---------------------------------------NFE 1697
            + R+          D  F                                       NF+
Sbjct: 284  ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343

Query: 1698 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVS 1757
             FG S + +F++ T   W+ L    L +                          +FFF+ 
Sbjct: 344  NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382

Query: 1758 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKL 1817
             I +    ++N+ +AV+    ++A EE  + ++ +      E  EK   +A Q ++ EK 
Sbjct: 383  VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433

Query: 1818 SQFAAALE 1825
            +  A  ++
Sbjct: 434  ALVAMGID 441



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 33/124 (26%), Positives = 55/124 (44%), Gaps = 27/124 (21%)

Query: 357  NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 398
            NP  G     +F TF+ + L LF++ T   W++L    LR+                  +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 399  YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMIEQLKKQQE 456
            Y + ++++ FL    ++N+ +AV+    E  N AT EE+E    E +F    E  +K   
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635

Query: 457  AAQQ 460
             A Q
Sbjct: 1636 EATQ 1639


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1006 bits (2602), Expect = 0.0
 Identities = 541/853 (63%), Positives = 623/853 (73%), Gaps = 61/853 (7%)

Query: 972  VLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEF---IQQSFI 1028
            VLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+ +G+ +VKR  ++F   + +   
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 1029 RKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDE 1088
            +K   L     L        S     T ++       +   G   G GT    E      
Sbjct: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745

Query: 1089 SDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDI 1148
                         V VPIAV ESD ++   ED  +    EE   K  ES   S G     
Sbjct: 746  -------------VCVPIAVAESDTDD-QEEDEENSLGTEEESSKQQESQPVSGGPE--- 788

Query: 1149 GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNW 1208
             AP + +   +   T   EA             + +  +   +Q W          E   
Sbjct: 789  -APPDSRTWSQVSATASSEA-------------EASASQADWRQQWKAEPQAPGCGE--- 831

Query: 1209 FETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1268
                            AFEDIY+++RKTIK +LEYADK+FTY+F+LEMLLKWVAYG++ Y
Sbjct: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875

Query: 1269 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1328
            FTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935

Query: 1329 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR-FDIEDVNNHTDCLK 1387
            L+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T GD   +   VNN + C  
Sbjct: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995

Query: 1388 LIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLY 1447
            L    E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++E +LY
Sbjct: 996  LNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLY 1054

Query: 1448 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507
            MY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKK
Sbjct: 1055 MYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1114

Query: 1508 PQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINL 1567
            PQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQS     IL++INL
Sbjct: 1115 PQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINL 1174

Query: 1568 VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1627
            +F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVI
Sbjct: 1175 LFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVI 1234

Query: 1628 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKRE 1687
            RLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E
Sbjct: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294

Query: 1688 VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGN 1747
             GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   N   S +GDCG+
Sbjct: 1295 AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGS 1353

Query: 1748 PSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPD 1807
            P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+
Sbjct: 1354 PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPE 1413

Query: 1808 ATQFMEFEKLSQF 1820
            ATQF+E+   ++F
Sbjct: 1414 ATQFIEYSCGTRF 1426



 Score =  690 bits (1780), Expect = 0.0
 Identities = 387/671 (57%), Positives = 459/671 (68%), Gaps = 64/671 (9%)

Query: 6   LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61
           L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121
           P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122 IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288

Query: 302 GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
           GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 289 GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 359 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 419 LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458

Query: 479 LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538
              SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 459 ---SSLEMSPLAPVNSHERRSKRRKRM---SSGTEECGEDRLPKSDSEDGPRAM------ 506

Query: 539 EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598
             N L+  +  S       S RGS+F+ RR             +D+GSE DFADDE+ST 
Sbjct: 507 --NHLSLTRGLSRTSMKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTA 551

Query: 599 EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657
            ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 552 GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608

Query: 658 SVPTSPVGQLL 668
              TSP   LL
Sbjct: 609 PEATSPGSHLL 619



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 83/355 (23%), Positives = 154/355 (43%), Gaps = 80/355 (22%)

Query: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
            +RR   +I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
             L+K +A G+     T+  + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1364
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1365 CINTTTGD--------------------------RFDIEDVNNHTD---------CLKLI 1389
             +N T G                             D+    N +D         CLK  
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1390 ERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMY 1449
            E  +     +   +FD+  + +L+L ++ T   W  +    + S            +YM 
Sbjct: 346  ENPD-----HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM- 390

Query: 1450 LYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1503
            ++F++ I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 391  IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 69/273 (25%), Positives = 125/273 (45%), Gaps = 40/273 (14%)

Query: 753  VVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMD 812
            +V     D+ I   I LN + M +E    +    N+L   NL+F  IFT E  +K+ A+ 
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191

Query: 813  PYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRLLRVFKLAKSWPT 864
             +YYF   WNIFD  +V LS+V   L+++            V+R  R+ R+ +L +    
Sbjct: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251

Query: 865  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMN 924
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y      I        ++  
Sbjct: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304

Query: 925  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC--------------------LTVFMMV 964
             F +S L +F++      + +   +   G   C                    +  F   
Sbjct: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364

Query: 965  MVIGNLVVLNLFLALLLSSFSADNLAATDDDNE 997
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 67/287 (23%), Positives = 129/287 (44%), Gaps = 70/287 (24%)

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 214
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F ++G + +
Sbjct: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969

Query: 275  NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDAL 334
             +CI           +  E ++ +NY  T++N        KS                  
Sbjct: 970  GRCI-----------NQTEGDLPLNY--TIVNN-------KSQ----------------- 992

Query: 335  LCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA 394
             C + +  G+    +  VK          +FD     +L+L ++ T   W ++    + +
Sbjct: 993  -CESLNLTGEL--YWTKVK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1040

Query: 395  AG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431
             G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1041 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 50/237 (21%), Positives = 102/237 (43%), Gaps = 39/237 (16%)

Query: 788  VLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE-----LGLANVE 842
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SLV      LG A + 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 843  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 902
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 903  KSYKDCVCKIASDCQL------------------------PRWHMNDFFHSFLIVFRVLC 938
              +  C+ +   D  L                         + + ++    +L + +V  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 939  GE-WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 21/191 (10%)

Query: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
           ++FS    ++  SP+    +  V ++V   F ++ I   I+ N +FMA    P    +  
Sbjct: 103 FRFSATNALYVLSPFHPIRRAAVKILVHSLF-NMLIMCTILTNCVFMAQHDPPPWTKYVE 161

Query: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIV----TLSLVELGLA 839
                   FT I+T E  +KI+A    +  + + ++ WN  D  ++    T   V+LG  
Sbjct: 162 Y------TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-- 213

Query: 840 NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 899
               +S LR+FR+LR  K       L  ++  +  SV  L ++ ++    + +FA++G+Q
Sbjct: 214 ---NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQ 270

Query: 900 LF-GKSYKDCV 909
           LF G     CV
Sbjct: 271 LFMGNLRHKCV 281



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 31/144 (21%), Positives = 70/144 (48%), Gaps = 13/144 (9%)

Query: 924  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSS 983
            + F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  +
Sbjct: 356  DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415

Query: 984  FSADNLAA-TDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDD 1042
            +   N A   + + +    Q A++ + K    +  +  + + +S +       E+ PL  
Sbjct: 416  YEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSL-------EMSPLAP 468

Query: 1043 LN-----NKKDSCMSNHTAEIGKD 1061
            +N     +K+   MS+ T E G+D
Sbjct: 469  VNSHERRSKRRKRMSSGTEECGED 492


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  334 bits (857), Expect = 4e-91
 Identities = 205/625 (32%), Positives = 344/625 (55%), Gaps = 39/625 (6%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C  I+ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184

Query: 1257 LLKWVA----YGYQTYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1309
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGV- 1303

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC+         RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1304 -----DTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL-RHYYFTIGWNIFDFVVVILSIVGM 1608
            E  +Q   + T L   N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531

Query: 1609 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1666
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591

Query: 1667 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1721
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651

Query: 1722 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1781
             L     DC  ++ +  SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701

Query: 1782 TEESAEPLSEDDFEMFYEVWEKFDP 1806
             +E+ E  +E D E+  E+     P
Sbjct: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725



 Score =  142 bits (357), Expect = 4e-33
 Identities = 82/281 (29%), Positives = 151/281 (53%), Gaps = 8/281 (2%)

Query: 736  IWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   +   N+L + N+V
Sbjct: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRV 855
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703

Query: 856  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASD 915
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +   +     D
Sbjct: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS--LRTDTGD 761

Query: 916  CQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLN 974
                R + +    + + VF++L  E W   +++ M        L  F+ +M  GN V+ N
Sbjct: 762  TVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGNYVLFN 820

Query: 975  LFLALLLSSFSAD---NLAATDDDNEMNNLQIAVDRMHKGV 1012
            L +A+L+  F A+   N + +D+D   +N++   D++ +G+
Sbjct: 821  LLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGL 860



 Score =  127 bits (320), Expect = 8e-29
 Identities = 108/422 (25%), Positives = 193/422 (45%), Gaps = 54/422 (12%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTMSNP-------PDWTKNVEYTFTGIYTF---ESLIKIIARGFC 179
           F  + M  IL NCV + M  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF ++    V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------IQWPPTNAS 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 LEEHSIEKNITVNYNGTLIN----ETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDA 342
            E+  +    +++ +  ++       + E   +  +     + F  G  D    G   + 
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNW 319

Query: 343 GQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIF 402
            +     +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 320 NRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 403 FVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAA 462
           F+L+I +GSF++INL L V+A  +          +E K+ E + M+EQ ++   ++  A+
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQRYLSSSTVAS 427

Query: 463 TA 464
            A
Sbjct: 428 YA 429



 Score =  105 bits (262), Expect = 4e-22
 Identities = 76/282 (26%), Positives = 136/282 (48%), Gaps = 34/282 (12%)

Query: 741  PYWLKVKH---VVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFT 797
            PY+    H   +++ +    ++D+ IT  I LN + M++EHY         L   N +FT
Sbjct: 1433 PYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFT 1492

Query: 798  GIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVE----------GLSVL 847
             +F  E  LK++A     +F++ WN  D  IV LS++ + L  +E           + ++
Sbjct: 1493 TVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIM 1552

Query: 848  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKD 907
            R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK    
Sbjct: 1553 RVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK---- 1608

Query: 908  CVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQAMCLT- 959
             VC   + C+    H    +F  +FL +F+V  G+ W     +T+ DC     +  CL+ 
Sbjct: 1609 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSS 1666

Query: 960  -------VFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                    F+  ++    V++N+ +A+L+      N  A +D
Sbjct: 1667 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708



 Score =  100 bits (250), Expect = 1e-20
 Identities = 83/333 (24%), Positives = 151/333 (45%), Gaps = 49/333 (14%)

Query: 1190 GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFT 1249
            G  W   R     IV+  +F   I+  IL+++ ++  E  + +Q + +  +LE  + VFT
Sbjct: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645

Query: 1250 YIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1309
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +  LRT R 
Sbjct: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF   + T 
Sbjct: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF--SLRTD 758

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
            TGD   + D                      + NFD++ +  +++ Q+ T + W  ++Y 
Sbjct: 759  TGD--TVPD----------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYN 794

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQD 1486
             + S           S +  LYFV  + FG++   NL + ++++ F  +    + +  +D
Sbjct: 795  GMAS----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDED 844

Query: 1487 IFMT--EEQKKYYNAMKKLGSKKPQKPIPRPGN 1517
               +  EE  K    +   G  K   PIP   N
Sbjct: 845  QSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 76/293 (25%), Positives = 136/293 (46%), Gaps = 42/293 (14%)

Query: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTT---ILSRINLVFIV 1571
            P N+F+ +    +  ++FD  ++  I LN +T+ +E   Q E  +T    L+  N +F  
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178

Query: 1572 LFTGECVLKLISLRHY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRV 1626
            +F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV
Sbjct: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238

Query: 1627 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVK 1685
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298

Query: 1686 REVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSK 1726
              +G+D                     +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358

Query: 1727 PPDCDP-NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1778
              D  P    NP              + +F+S+++I    V+NM++ V++ENF
Sbjct: 1359 AVDQQPVTNHNPWM------------LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 60/176 (34%), Positives = 96/176 (54%), Gaps = 11/176 (6%)

Query: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQ---RKTIKTMLEYADKV 1247
            +Q  + R  C ++V + WFE   + +ILL+   L       D        K +  + D +
Sbjct: 63   RQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFI 122

Query: 1248 FTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1304
            F + F +EM+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++
Sbjct: 123  FIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAI 177

Query: 1305 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360
            RT+R LRPL+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 178  RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 71/270 (26%), Positives = 129/270 (47%), Gaps = 39/270 (14%)

Query: 753  VVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN---VLTVGNLVFTGIFTAEMFLKII 809
            ++     D  +   I LN + +A+E  P  +  +     LTV N +FT IF  EM LK++
Sbjct: 1131 IIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVV 1189

Query: 810  AMDPYY----YFQEGWNIFDGFIVTLSLVEL--GLANVEG------LSVLRSFRLLRVFK 857
            ++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L VLR  R LR  +
Sbjct: 1190 SLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLR 1249

Query: 858  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCV------CK 911
            +    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+        
Sbjct: 1250 VISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNIT 1309

Query: 912  IASDCQLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 954
              SDC     RW  H  +F      L+   VL  +  W+  M++ ++             
Sbjct: 1310 NRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHN 1369

Query: 955  AMCLTVFMMVMVIGNLVVLNLFLALLLSSF 984
               L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1370 PWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 52/182 (28%), Positives = 90/182 (49%), Gaps = 17/182 (9%)

Query: 107  ALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + +  P     + E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 159  YTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 270  MG 271
             G
Sbjct: 1294 KG 1295



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 74/283 (26%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F+  IM+ I +N V+M +E  +Q E +T IL   N+VF  +F  E +LKL +   
Sbjct: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1700
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773

Query: 1701 NSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYII 1760
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812

Query: 1761 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1803
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 33/98 (33%), Positives = 61/98 (62%), Gaps = 13/98 (13%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++ + QV T +GW++IMY  +D+           S Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1499
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 46/160 (28%), Positives = 86/160 (53%), Gaps = 14/160 (8%)

Query: 753 VVMDPFVDLAITICIVLNTLFMAMEHYP------MTDHFNNVLTVGNLVFTGIFTAEMFL 806
           +V +P+ +    + I+LN + + M + P      ++D    +    + +F   F  EM L
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 807 KIIAMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKS 861
           K++A+  +    Y  + WN  D FIV   +VE  L L N+  LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINR 191

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/148 (29%), Positives = 81/148 (54%), Gaps = 13/148 (8%)

Query: 130 FSMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKIIARGFCLEDF 183
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662

Query: 184 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 15/163 (9%)

Query: 1532 FDISIMILICLNMVTM-MVETDDQSEYVTT---ILSRINLVFIVLFTGECVLKLISL--- 1584
            F+   M++I LN VT+ M +  D  + ++    IL   +    + F  E VLK+++L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1585 -RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1643
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1644 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 21/93 (22%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 364 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 424 MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQE 456
             ++ +  A    +++ ++     IE+  K QE
Sbjct: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 15/146 (10%)

Query: 362  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 410
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682

Query: 411  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHS 470
             F LIN+++AV+    ++ N+   E+AE  +AE +    ++        +  T +     
Sbjct: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELEL---EMAHGLGPGPRLPTGSPGAPG 1738

Query: 471  REPSAAGRLSDSSSEASKLSSKSAKE 496
            R P  AG   D+     +     A+E
Sbjct: 1739 RGPGGAGGGGDTEGGLCRRCYSPAQE 1764



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 928 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  334 bits (857), Expect = 4e-91
 Identities = 205/625 (32%), Positives = 344/625 (55%), Gaps = 39/625 (6%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C  I+ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219

Query: 1257 LLKWVA----YGYQTYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1309
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGV- 1338

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC+         RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1339 -----DTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL-RHYYFTIGWNIFDFVVVILSIVGM 1608
            E  +Q   + T L   N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566

Query: 1609 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1666
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626

Query: 1667 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1721
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686

Query: 1722 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1781
             L     DC  ++ +  SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736

Query: 1782 TEESAEPLSEDDFEMFYEVWEKFDP 1806
             +E+ E  +E D E+  E+     P
Sbjct: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760



 Score =  142 bits (357), Expect = 4e-33
 Identities = 82/281 (29%), Positives = 151/281 (53%), Gaps = 8/281 (2%)

Query: 736  IWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   +   N+L + N+V
Sbjct: 619  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRV 855
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 679  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738

Query: 856  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASD 915
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +   +     D
Sbjct: 739  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS--LRTDTGD 796

Query: 916  CQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLN 974
                R + +    + + VF++L  E W   +++ M        L  F+ +M  GN V+ N
Sbjct: 797  TVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGNYVLFN 855

Query: 975  LFLALLLSSFSAD---NLAATDDDNEMNNLQIAVDRMHKGV 1012
            L +A+L+  F A+   N + +D+D   +N++   D++ +G+
Sbjct: 856  LLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGL 895



 Score =  127 bits (320), Expect = 8e-29
 Identities = 108/422 (25%), Positives = 193/422 (45%), Gaps = 54/422 (12%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTMSNP-------PDWTKNVEYTFTGIYTF---ESLIKIIARGFC 179
           F  + M  IL NCV + M  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF ++    V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------IQWPPTNAS 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 LEEHSIEKNITVNYNGTLIN----ETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDA 342
            E+  +    +++ +  ++       + E   +  +     + F  G  D    G   + 
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNW 319

Query: 343 GQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIF 402
            +     +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 320 NRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 403 FVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAA 462
           F+L+I +GSF++INL L V+A  +          +E K+ E + M+EQ ++   ++  A+
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQRYLSSSTVAS 427

Query: 463 TA 464
            A
Sbjct: 428 YA 429



 Score =  105 bits (262), Expect = 4e-22
 Identities = 76/282 (26%), Positives = 136/282 (48%), Gaps = 34/282 (12%)

Query: 741  PYWLKVKH---VVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFT 797
            PY+    H   +++ +    ++D+ IT  I LN + M++EHY         L   N +FT
Sbjct: 1468 PYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFT 1527

Query: 798  GIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVE----------GLSVL 847
             +F  E  LK++A     +F++ WN  D  IV LS++ + L  +E           + ++
Sbjct: 1528 TVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIM 1587

Query: 848  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKD 907
            R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK    
Sbjct: 1588 RVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK---- 1643

Query: 908  CVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQAMCLT- 959
             VC   + C+    H    +F  +FL +F+V  G+ W     +T+ DC     +  CL+ 
Sbjct: 1644 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSS 1701

Query: 960  -------VFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                    F+  ++    V++N+ +A+L+      N  A +D
Sbjct: 1702 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743



 Score =  100 bits (250), Expect = 1e-20
 Identities = 83/333 (24%), Positives = 151/333 (45%), Gaps = 49/333 (14%)

Query: 1190 GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFT 1249
            G  W   R     IV+  +F   I+  IL+++ ++  E  + +Q + +  +LE  + VFT
Sbjct: 623  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680

Query: 1250 YIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1309
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +  LRT R 
Sbjct: 681  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF   + T 
Sbjct: 736  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF--SLRTD 793

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
            TGD   + D                      + NFD++ +  +++ Q+ T + W  ++Y 
Sbjct: 794  TGD--TVPD----------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYN 829

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQD 1486
             + S           S +  LYFV  + FG++   NL + ++++ F  +    + +  +D
Sbjct: 830  GMAS----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDED 879

Query: 1487 IFMT--EEQKKYYNAMKKLGSKKPQKPIPRPGN 1517
               +  EE  K    +   G  K   PIP   N
Sbjct: 880  QSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 76/293 (25%), Positives = 136/293 (46%), Gaps = 42/293 (14%)

Query: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTT---ILSRINLVFIV 1571
            P N+F+ +    +  ++FD  ++  I LN +T+ +E   Q E  +T    L+  N +F  
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213

Query: 1572 LFTGECVLKLISLRHY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRV 1626
            +F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV
Sbjct: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273

Query: 1627 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVK 1685
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333

Query: 1686 REVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSK 1726
              +G+D                     +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393

Query: 1727 PPDCDP-NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1778
              D  P    NP              + +F+S+++I    V+NM++ V++ENF
Sbjct: 1394 AVDQQPVTNHNPWM------------LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 60/176 (34%), Positives = 96/176 (54%), Gaps = 11/176 (6%)

Query: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQ---RKTIKTMLEYADKV 1247
            +Q  + R  C ++V + WFE   + +ILL+   L       D        K +  + D +
Sbjct: 63   RQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFI 122

Query: 1248 FTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1304
            F + F +EM+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++
Sbjct: 123  FIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAI 177

Query: 1305 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360
            RT+R LRPL+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 178  RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 71/270 (26%), Positives = 129/270 (47%), Gaps = 39/270 (14%)

Query: 753  VVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN---VLTVGNLVFTGIFTAEMFLKII 809
            ++     D  +   I LN + +A+E  P  +  +     LTV N +FT IF  EM LK++
Sbjct: 1166 IIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVV 1224

Query: 810  AMDPYY----YFQEGWNIFDGFIVTLSLVEL--GLANVEG------LSVLRSFRLLRVFK 857
            ++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L VLR  R LR  +
Sbjct: 1225 SLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLR 1284

Query: 858  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCV------CK 911
            +    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+        
Sbjct: 1285 VISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNIT 1344

Query: 912  IASDCQLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 954
              SDC     RW  H  +F      L+   VL  +  W+  M++ ++             
Sbjct: 1345 NRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHN 1404

Query: 955  AMCLTVFMMVMVIGNLVVLNLFLALLLSSF 984
               L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1405 PWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 52/182 (28%), Positives = 90/182 (49%), Gaps = 17/182 (9%)

Query: 107  ALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + +  P     + E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 159  YTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 270  MG 271
             G
Sbjct: 1329 KG 1330



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 74/283 (26%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F+  IM+ I +N V+M +E  +Q E +T IL   N+VF  +F  E +LKL +   
Sbjct: 637  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 697  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1700
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 749  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808

Query: 1701 NSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYII 1760
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 809  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847

Query: 1761 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1803
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 848  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 33/98 (33%), Positives = 61/98 (62%), Gaps = 13/98 (13%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++ + QV T +GW++IMY  +D+           S Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1499
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 46/160 (28%), Positives = 86/160 (53%), Gaps = 14/160 (8%)

Query: 753 VVMDPFVDLAITICIVLNTLFMAMEHYP------MTDHFNNVLTVGNLVFTGIFTAEMFL 806
           +V +P+ +    + I+LN + + M + P      ++D    +    + +F   F  EM L
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 807 KIIAMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKS 861
           K++A+  +    Y  + WN  D FIV   +VE  L L N+  LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINR 191

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/148 (29%), Positives = 81/148 (54%), Gaps = 13/148 (8%)

Query: 130 FSMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKIIARGFCLEDF 183
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697

Query: 184 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 757 KTMDNVATFCMLLMLFIFIFSILGMHIF 784



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 15/163 (9%)

Query: 1532 FDISIMILICLNMVTM-MVETDDQSEYVTT---ILSRINLVFIVLFTGECVLKLISL--- 1584
            F+   M++I LN VT+ M +  D  + ++    IL   +    + F  E VLK+++L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1585 -RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1643
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1644 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 21/93 (22%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 364 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862

Query: 424 MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQE 456
             ++ +  A    +++ ++     IE+  K QE
Sbjct: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 15/146 (10%)

Query: 362  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 410
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717

Query: 411  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHS 470
             F LIN+++AV+    ++ N+   E+AE  +AE +    ++        +  T +     
Sbjct: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELEL---EMAHGLGPGPRLPTGSPGAPG 1773

Query: 471  REPSAAGRLSDSSSEASKLSSKSAKE 496
            R P  AG   D+     +     A+E
Sbjct: 1774 RGPGGAGGGGDTEGGLCRRCYSPAQE 1799



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 928 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1421

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1422 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  139 bits (350), Expect = 3e-32
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 13/251 (5%)

Query: 742 YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
           +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728 FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802 AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788 LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918 LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
             R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977 LALLLSSFSAD 987
           +A+L+  F A+
Sbjct: 960 VAILVEGFQAE 970



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (276), Expect = 1e-23
 Identities = 135/674 (20%), Positives = 265/674 (39%), Gaps = 114/674 (16%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSR-EPSAAGRLSDS 482
              ++ +      +A + E+E       L    +  +  A  +  EH     S    L   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 483  SSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNR 542
            ++       KS             +  S     +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 543  LTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVGSENDFADDEHSTFE 599
                   SSPH    +   S ++ RR+SR SL    S + R+      +  + +   + +
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQD 1118

Query: 600  DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV----------DCNG 649
            + ES  +    P     R   +L + ++SS  L        +H T           DCNG
Sbjct: 1119 EEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG 1178

Query: 650  VVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL 709
                        S  G+L           R  R     +  D  +D     +   + + +
Sbjct: 1179 -----------KSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 710  TNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLVVMDPFVDLAITICI 767
                      R + P C  +  +    W     P   + + + + ++     D  + + I
Sbjct: 1218 ----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 768  VLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAMDPYY----YFQEGW 821
             LN + +AME   +  H      LT+ N +FT +F AEM +K++A+   +    Y +  W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 822  NIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 873
            N+ DG +V +S++++ ++ V          L VLR  R LR  ++      L ++++ + 
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 874  NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------SDCQLP--RW--HM 923
            +S+  +GN+ ++      IF ++G+QLF   +  C  +        SDC     RW  H 
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK 1443

Query: 924  NDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNL 970
             +F      L+   VL  +  W++ M+D ++  G             L  F+  ++I   
Sbjct: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503

Query: 971  VVLNLFLALLLSSF 984
             VLN+F+ +++ +F
Sbjct: 1504 FVLNMFVGVVVENF 1517



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/287 (24%), Positives = 135/287 (47%), Gaps = 45/287 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1478
             S           S +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKREVGIDDMFNFETFGN 1701
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1702 SMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIII 1761
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1762 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1794
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1739

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1740 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1785



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1563

Query: 470  SR 471
            SR
Sbjct: 1564 SR 1565



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1421

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1422 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  139 bits (350), Expect = 3e-32
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 13/251 (5%)

Query: 742 YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
           +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728 FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802 AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788 LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918 LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
             R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977 LALLLSSFSAD 987
           +A+L+  F A+
Sbjct: 960 VAILVEGFQAE 970



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (276), Expect = 1e-23
 Identities = 135/674 (20%), Positives = 265/674 (39%), Gaps = 114/674 (16%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSR-EPSAAGRLSDS 482
              ++ +      +A + E+E       L    +  +  A  +  EH     S    L   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 483  SSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNR 542
            ++       KS             +  S     +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 543  LTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVGSENDFADDEHSTFE 599
                   SSPH    +   S ++ RR+SR SL    S + R+      +  + +   + +
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQD 1118

Query: 600  DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV----------DCNG 649
            + ES  +    P     R   +L + ++SS  L        +H T           DCNG
Sbjct: 1119 EEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG 1178

Query: 650  VVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL 709
                        S  G+L           R  R     +  D  +D     +   + + +
Sbjct: 1179 -----------KSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 710  TNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLVVMDPFVDLAITICI 767
                      R + P C  +  +    W     P   + + + + ++     D  + + I
Sbjct: 1218 ----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 768  VLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAMDPYY----YFQEGW 821
             LN + +AME   +  H      LT+ N +FT +F AEM +K++A+   +    Y +  W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 822  NIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 873
            N+ DG +V +S++++ ++ V          L VLR  R LR  ++      L ++++ + 
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 874  NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------SDCQLP--RW--HM 923
            +S+  +GN+ ++      IF ++G+QLF   +  C  +        SDC     RW  H 
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK 1443

Query: 924  NDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNL 970
             +F      L+   VL  +  W++ M+D ++  G             L  F+  ++I   
Sbjct: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503

Query: 971  VVLNLFLALLLSSF 984
             VLN+F+ +++ +F
Sbjct: 1504 FVLNMFVGVVVENF 1517



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/287 (24%), Positives = 135/287 (47%), Gaps = 45/287 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1478
             S           S +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKREVGIDDMFNFETFGN 1701
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1702 SMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIII 1761
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1762 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1794
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1739

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1740 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1785



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1563

Query: 470  SR 471
            SR
Sbjct: 1564 SR 1565



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1444

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1445 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1553

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1554 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1613

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1614 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1673

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1674 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1733

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1734 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1793

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1794 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1840

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1841 KHLEESNKEAKE 1852



 Score =  145 bits (367), Expect = 3e-34
 Identities = 83/271 (30%), Positives = 147/271 (54%), Gaps = 14/271 (5%)

Query: 742  YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
            +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802  AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
             EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788  LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
             P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918  LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
              R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977  LALLLSSFSADNLAATDD-DNEMNNLQIAVD 1006
            +A+L+  F A+ ++  +D   +++ +Q+ VD
Sbjct: 960  VAILVEGFQAEEISKREDASGQLSCIQLPVD 990



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (275), Expect = 1e-23
 Identities = 141/688 (20%), Positives = 271/688 (39%), Gaps = 119/688 (17%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSS 483
              ++ +  +  E+A  + +  Q  ++          Q   A  SE   EP       D  
Sbjct: 965  EGFQAEEISKREDASGQLSCIQLPVDS---------QGGDANKSES--EPDFFSPSLDGD 1013

Query: 484  SEASK-LSSKSAKERRNRRKK--------------RKQKEQSGGEEKDEDEFQKSESEDS 528
             +  K L+  S  E    RK                  K  S G  +      +  S   
Sbjct: 1014 GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSG 1073

Query: 529  IRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVG 585
                G    ++          SSPH    +   S ++ RR+SR SL    S + R+    
Sbjct: 1074 SAEPGAAHEMKSP----PSARSSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGE 1127

Query: 586  SENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV 645
              +  + +   + ++ ES  +    P     R   +L + ++SS  L        +H T 
Sbjct: 1128 RRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTA 1187

Query: 646  ----------DCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLED 695
                      DCNG            S  G+L           R  R     +  D  +D
Sbjct: 1188 SGRGSASEHQDCNG-----------KSASGRLA----------RALRPDDPPLDGDDADD 1226

Query: 696  PSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLV 753
                 +   + + +          R + P C  +  +    W     P   + + + + +
Sbjct: 1227 EGNLSKGERVRAWI----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRI 1272

Query: 754  VMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAM 811
            +     D  + + I LN + +AME   +  H      LT+ N +FT +F AEM +K++A+
Sbjct: 1273 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 812  DPYY----YFQEGWNIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLA 859
               +    Y +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++ 
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 860  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------ 913
                 L ++++ + +S+  +GN+ ++      IF ++G+QLF   +  C  +        
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 914  SDCQLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAM 956
            SDC     RW  H  +F      L+   VL  +  W++ M+D ++  G            
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 957  CLTVFMMVMVIGNLVVLNLFLALLLSSF 984
             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1579 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1755

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1756 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1814

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1815 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/288 (24%), Positives = 136/288 (47%), Gaps = 45/288 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1479
             S           S +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 72/272 (26%), Positives = 122/272 (44%), Gaps = 40/272 (14%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1698
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1699 FGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSY 1758
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1759 IIISFLVVVNMYIAVILENFSVATEESAEPLS 1790
            +     V+ N+ +A+++E F        E  S
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1758 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1812

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1813 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1870



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1706 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1762

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1763 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1808



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1586

Query: 470  SR 471
            SR
Sbjct: 1587 SR 1588



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1421

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1422 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  139 bits (350), Expect = 3e-32
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 13/251 (5%)

Query: 742 YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
           +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728 FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802 AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788 LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918 LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
             R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977 LALLLSSFSAD 987
           +A+L+  F A+
Sbjct: 960 VAILVEGFQAE 970



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (276), Expect = 1e-23
 Identities = 135/674 (20%), Positives = 265/674 (39%), Gaps = 114/674 (16%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSR-EPSAAGRLSDS 482
              ++ +      +A + E+E       L    +  +  A  +  EH     S    L   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 483  SSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNR 542
            ++       KS             +  S     +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 543  LTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVGSENDFADDEHSTFE 599
                   SSPH    +   S ++ RR+SR SL    S + R+      +  + +   + +
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQD 1118

Query: 600  DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV----------DCNG 649
            + ES  +    P     R   +L + ++SS  L        +H T           DCNG
Sbjct: 1119 EEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG 1178

Query: 650  VVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL 709
                        S  G+L           R  R     +  D  +D     +   + + +
Sbjct: 1179 -----------KSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 710  TNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLVVMDPFVDLAITICI 767
                      R + P C  +  +    W     P   + + + + ++     D  + + I
Sbjct: 1218 ----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 768  VLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAMDPYY----YFQEGW 821
             LN + +AME   +  H      LT+ N +FT +F AEM +K++A+   +    Y +  W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 822  NIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 873
            N+ DG +V +S++++ ++ V          L VLR  R LR  ++      L ++++ + 
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 874  NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------SDCQLP--RW--HM 923
            +S+  +GN+ ++      IF ++G+QLF   +  C  +        SDC     RW  H 
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK 1443

Query: 924  NDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNL 970
             +F      L+   VL  +  W++ M+D ++  G             L  F+  ++I   
Sbjct: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503

Query: 971  VVLNLFLALLLSSF 984
             VLN+F+ +++ +F
Sbjct: 1504 FVLNMFVGVVVENF 1517



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/287 (24%), Positives = 135/287 (47%), Gaps = 45/287 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1478
             S           S +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKREVGIDDMFNFETFGN 1701
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1702 SMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIII 1761
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1762 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1794
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1739

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1740 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1785



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1563

Query: 470  SR 471
            SR
Sbjct: 1564 SR 1565



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1444

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1445 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1553

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1554 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1613

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1614 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1673

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1674 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1733

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1734 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1793

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1794 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1840

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1841 KHLEESNKEAKE 1852



 Score =  145 bits (367), Expect = 3e-34
 Identities = 83/271 (30%), Positives = 147/271 (54%), Gaps = 14/271 (5%)

Query: 742  YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
            +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802  AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
             EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788  LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
             P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918  LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
              R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977  LALLLSSFSADNLAATDD-DNEMNNLQIAVD 1006
            +A+L+  F A+ ++  +D   +++ +Q+ VD
Sbjct: 960  VAILVEGFQAEEISKREDASGQLSCIQLPVD 990



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (275), Expect = 1e-23
 Identities = 141/688 (20%), Positives = 271/688 (39%), Gaps = 119/688 (17%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSS 483
              ++ +  +  E+A  + +  Q  ++          Q   A  SE   EP       D  
Sbjct: 965  EGFQAEEISKREDASGQLSCIQLPVDS---------QGGDANKSES--EPDFFSPSLDGD 1013

Query: 484  SEASK-LSSKSAKERRNRRKK--------------RKQKEQSGGEEKDEDEFQKSESEDS 528
             +  K L+  S  E    RK                  K  S G  +      +  S   
Sbjct: 1014 GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSG 1073

Query: 529  IRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVG 585
                G    ++          SSPH    +   S ++ RR+SR SL    S + R+    
Sbjct: 1074 SAEPGAAHEMKSP----PSARSSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGE 1127

Query: 586  SENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV 645
              +  + +   + ++ ES  +    P     R   +L + ++SS  L        +H T 
Sbjct: 1128 RRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTA 1187

Query: 646  ----------DCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLED 695
                      DCNG            S  G+L           R  R     +  D  +D
Sbjct: 1188 SGRGSASEHQDCNG-----------KSASGRLA----------RALRPDDPPLDGDDADD 1226

Query: 696  PSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLV 753
                 +   + + +          R + P C  +  +    W     P   + + + + +
Sbjct: 1227 EGNLSKGERVRAWI----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRI 1272

Query: 754  VMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAM 811
            +     D  + + I LN + +AME   +  H      LT+ N +FT +F AEM +K++A+
Sbjct: 1273 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 812  DPYY----YFQEGWNIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLA 859
               +    Y +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++ 
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 860  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------ 913
                 L ++++ + +S+  +GN+ ++      IF ++G+QLF   +  C  +        
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 914  SDCQLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAM 956
            SDC     RW  H  +F      L+   VL  +  W++ M+D ++  G            
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 957  CLTVFMMVMVIGNLVVLNLFLALLLSSF 984
             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1579 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1755

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1756 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1814

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1815 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/288 (24%), Positives = 136/288 (47%), Gaps = 45/288 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1479
             S           S +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 72/272 (26%), Positives = 122/272 (44%), Gaps = 40/272 (14%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1698
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1699 FGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSY 1758
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1759 IIISFLVVVNMYIAVILENFSVATEESAEPLS 1790
            +     V+ N+ +A+++E F        E  S
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1758 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1812

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1813 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1870



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1706 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1762

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1763 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1808



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1586

Query: 470  SR 471
            SR
Sbjct: 1587 SR 1588



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score =  331 bits (849), Expect = 4e-90
 Identities = 198/612 (32%), Positives = 338/612 (55%), Gaps = 46/612 (7%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1421

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1422 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1490 TEEQKKYYNAMKKLGSKKPQ------KPIPRPGNKFQGMVFDFVTRQVFDISIMILICLN 1543
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1544 MVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVI 1602
            +VTM +E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1603 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1660
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1661 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1715
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1716 DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1775
            +G++   L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1776 ENFSVATEESAE 1787
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  139 bits (350), Expect = 3e-32
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 13/251 (5%)

Query: 742 YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
           +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728 FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802 AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788 LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918 LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
             R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977 LALLLSSFSAD 987
           +A+L+  F A+
Sbjct: 960 VAILVEGFQAE 970



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (276), Expect = 1e-23
 Identities = 135/674 (20%), Positives = 265/674 (39%), Gaps = 114/674 (16%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSR-EPSAAGRLSDS 482
              ++ +      +A + E+E       L    +  +  A  +  EH     S    L   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 483  SSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNR 542
            ++       KS             +  S     +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 543  LTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVGSENDFADDEHSTFE 599
                   SSPH    +   S ++ RR+SR SL    S + R+      +  + +   + +
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQD 1118

Query: 600  DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV----------DCNG 649
            + ES  +    P     R   +L + ++SS  L        +H T           DCNG
Sbjct: 1119 EEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG 1178

Query: 650  VVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL 709
                        S  G+L           R  R     +  D  +D     +   + + +
Sbjct: 1179 -----------KSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 710  TNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLVVMDPFVDLAITICI 767
                      R + P C  +  +    W     P   + + + + ++     D  + + I
Sbjct: 1218 ----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 768  VLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAMDPYY----YFQEGW 821
             LN + +AME   +  H      LT+ N +FT +F AEM +K++A+   +    Y +  W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 822  NIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 873
            N+ DG +V +S++++ ++ V          L VLR  R LR  ++      L ++++ + 
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 874  NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------SDCQLP--RW--HM 923
            +S+  +GN+ ++      IF ++G+QLF   +  C  +        SDC     RW  H 
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK 1443

Query: 924  NDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNL 970
             +F      L+   VL  +  W++ M+D ++  G             L  F+  ++I   
Sbjct: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503

Query: 971  VVLNLFLALLLSSF 984
             VLN+F+ +++ +F
Sbjct: 1504 FVLNMFVGVVVENF 1517



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/287 (24%), Positives = 135/287 (47%), Gaps = 45/287 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1478
             S           S +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKREVGIDDMFNFETFGN 1701
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1702 SMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIII 1761
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1762 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1794
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1739

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1740 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1785



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 15/122 (12%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEH 469
            ++N+ + VV   + +  Q   EE E +  E +++    KK++   +Q A A      S++
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQ-EEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDY 1563

Query: 470  SR 471
            SR
Sbjct: 1564 SR 1565



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score =  331 bits (848), Expect = 5e-90
 Identities = 196/606 (32%), Positives = 335/606 (55%), Gaps = 41/606 (6%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1421

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1422 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
             EE  K    ++K   K   KP     ++F+ +V    T    D+ I  +I LN+VTM +
Sbjct: 1532 REE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1589

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVILSIVGM 1608
            E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+LSI+G+
Sbjct: 1590 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1649

Query: 1609 FLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1666
             L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+GLL 
Sbjct: 1650 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1709

Query: 1667 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1721
             L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G++  
Sbjct: 1710 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1769

Query: 1722 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1781
             L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++++   +
Sbjct: 1770 TLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEES 1816

Query: 1782 TEESAE 1787
             +E+ E
Sbjct: 1817 NKEAKE 1822



 Score =  139 bits (350), Expect = 3e-32
 Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 13/251 (5%)

Query: 742 YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
           +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728 FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802 AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788 LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918 LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
             R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977 LALLLSSFSAD 987
           +A+L+  F A+
Sbjct: 960 VAILVEGFQAE 970



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (276), Expect = 1e-23
 Identities = 135/674 (20%), Positives = 265/674 (39%), Gaps = 114/674 (16%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSR-EPSAAGRLSDS 482
              ++ +      +A + E+E       L    +  +  A  +  EH     S    L   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 483  SSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNR 542
            ++       KS             +  S     +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 543  LTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVGSENDFADDEHSTFE 599
                   SSPH    +   S ++ RR+SR SL    S + R+      +  + +   + +
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQD 1118

Query: 600  DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV----------DCNG 649
            + ES  +    P     R   +L + ++SS  L        +H T           DCNG
Sbjct: 1119 EEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNG 1178

Query: 650  VVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL 709
                        S  G+L           R  R     +  D  +D     +   + + +
Sbjct: 1179 -----------KSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 710  TNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLVVMDPFVDLAITICI 767
                      R + P C  +  +    W     P   + + + + ++     D  + + I
Sbjct: 1218 ----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1263

Query: 768  VLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAMDPYY----YFQEGW 821
             LN + +AME   +  H      LT+ N +FT +F AEM +K++A+   +    Y +  W
Sbjct: 1264 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSW 1323

Query: 822  NIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 873
            N+ DG +V +S++++ ++ V          L VLR  R LR  ++      L ++++ + 
Sbjct: 1324 NVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1383

Query: 874  NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------SDCQLP--RW--HM 923
            +S+  +GN+ ++      IF ++G+QLF   +  C  +        SDC     RW  H 
Sbjct: 1384 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK 1443

Query: 924  NDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNL 970
             +F      L+   VL  +  W++ M+D ++  G             L  F+  ++I   
Sbjct: 1444 YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAF 1503

Query: 971  VVLNLFLALLLSSF 984
             VLN+F+ +++ +F
Sbjct: 1504 FVLNMFVGVVVENF 1517



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1549 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1608

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1609 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1668

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1669 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1725

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1726 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1784

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1785 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1823



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/287 (24%), Positives = 135/287 (47%), Gaps = 45/287 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1478
             S           S +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1645
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1646 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKREVGIDDMFNFETFGN 1701
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1702 SMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIII 1761
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1762 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1794
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1728 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1782

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1783 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1840



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1560 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1619

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1620 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1675

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1676 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1732

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1733 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1778



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.0 bits (92), Expect = 0.023
 Identities = 25/106 (23%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQ 459
            ++N+ + VV   + +  Q   EE  ++  E  + + +L+K++  AQ
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREE--KRLRRLEKKRRKAQ 1548



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score =  331 bits (848), Expect = 5e-90
 Identities = 196/606 (32%), Positives = 335/606 (55%), Gaps = 41/606 (6%)

Query: 1197 RRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEM 1256
            R  C RI+ H  F+  ++ +I L+   +A E   ID     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1257 LLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1309
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1310 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT 1369
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGE- 1444

Query: 1370 TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429
                 D  ++ N +DC +      + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1445 -----DTRNITNKSDCAEA-----SYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489
             +D+  V+ QP    + +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549
             EE  K    ++K   K   KP     ++F+ +V    T    D+ I  +I LN+VTM +
Sbjct: 1555 REE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1612

Query: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVILSIVGM 1608
            E   Q + +   L   N +F V+F  E V KL++     +F   WN  D  +V+LSI+G+
Sbjct: 1613 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1672

Query: 1609 FLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1666
             L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+GLL 
Sbjct: 1673 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1732

Query: 1667 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1721
             L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G++  
Sbjct: 1733 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1792

Query: 1722 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1781
             L     DCD          +  C N  +   +FVS+++ +  V+VN+ IAV++++   +
Sbjct: 1793 TLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEES 1839

Query: 1782 TEESAE 1787
             +E+ E
Sbjct: 1840 NKEAKE 1845



 Score =  145 bits (367), Expect = 3e-34
 Identities = 83/271 (30%), Positives = 147/271 (54%), Gaps = 14/271 (5%)

Query: 742  YWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFT 801
            +W  +      +V   +    I I I++NTL M +E++   +   N L + N+VFT +F 
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFA 787

Query: 802  AEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKS 861
             EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL + 
Sbjct: 788  LEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 862  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS----DCQ 917
             P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK AS    D  
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTL 900

Query: 918  LPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLF 976
              R + +    + + VF++L  E W + +++ M  +  +     F+ +M  GN V+ NL 
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLL 959

Query: 977  LALLLSSFSADNLAATDD-DNEMNNLQIAVD 1006
            +A+L+  F A+ ++  +D   +++ +Q+ VD
Sbjct: 960  VAILVEGFQAEEISKREDASGQLSCIQLPVD 990



 Score =  119 bits (297), Expect = 4e-26
 Identities = 94/352 (26%), Positives = 167/352 (47%), Gaps = 31/352 (8%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNA 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 286 SLEEHSIEKNITVNYNGTLINETVF--EFDWKSYIQDSRYHYFLEG-FLDALLCG----- 337
           SL    +  ++   Y     +E+ F      ++ ++  R    L G       CG     
Sbjct: 248 SL---PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEA 304

Query: 338 -NSSDAGQCPEGYM----CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL 392
            NSS    C         C     NP  G  +FD   +A++++F+++T + W ++    +
Sbjct: 305 YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM 364

Query: 393 RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 444
            A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 365 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  110 bits (275), Expect = 1e-23
 Identities = 141/688 (20%), Positives = 271/688 (39%), Gaps = 119/688 (17%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 424  MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSS 483
              ++ +  +  E+A  + +  Q  ++          Q   A  SE   EP       D  
Sbjct: 965  EGFQAEEISKREDASGQLSCIQLPVDS---------QGGDANKSES--EPDFFSPSLDGD 1013

Query: 484  SEASK-LSSKSAKERRNRRKK--------------RKQKEQSGGEEKDEDEFQKSESEDS 528
             +  K L+  S  E    RK                  K  S G  +      +  S   
Sbjct: 1014 GDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSG 1073

Query: 529  IRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLF---SFRGRAKDVG 585
                G    ++          SSPH    +   S ++ RR+SR SL    S + R+    
Sbjct: 1074 SAEPGAAHEMKSP----PSARSSPHSPWSA--ASSWTSRRSSRNSLGRAPSLKRRSPSGE 1127

Query: 586  SENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTV 645
              +  + +   + ++ ES  +    P     R   +L + ++SS  L        +H T 
Sbjct: 1128 RRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTA 1187

Query: 646  ----------DCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLED 695
                      DCNG            S  G+L           R  R     +  D  +D
Sbjct: 1188 SGRGSASEHQDCNG-----------KSASGRLA----------RALRPDDPPLDGDDADD 1226

Query: 696  PSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCS--PYWLKVKHVVNLV 753
                 +   + + +          R + P C  +  +    W     P   + + + + +
Sbjct: 1227 EGNLSKGERVRAWI----------RARLPACCLERDS----WSAYIFPPQSRFRLLCHRI 1272

Query: 754  VMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN--VLTVGNLVFTGIFTAEMFLKIIAM 811
            +     D  + + I LN + +AME   +  H      LT+ N +FT +F AEM +K++A+
Sbjct: 1273 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1332

Query: 812  DPYY----YFQEGWNIFDGFIVTLSLVELGLANVEG--------LSVLRSFRLLRVFKLA 859
               +    Y +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++ 
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392

Query: 860  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA------ 913
                 L ++++ + +S+  +GN+ ++      IF ++G+QLF   +  C  +        
Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452

Query: 914  SDCQLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------QAM 956
            SDC     RW  H  +F      L+   VL  +  W++ M+D ++  G            
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 957  CLTVFMMVMVIGNLVVLNLFLALLLSSF 984
             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  109 bits (272), Expect = 3e-23
 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 739  CSPYWL---KVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLV 795
            C PY+    + + +V+ +    ++DL IT  I LN + MAMEHY      +  L + N +
Sbjct: 1572 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1631

Query: 796  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG----------LS 845
            FT IF  E   K++A     +FQ+ WN  D  IV LS++ + L  +E           + 
Sbjct: 1632 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1691

Query: 846  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1692 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1748

Query: 906  KDCVCKIASDCQLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-AMCLTV- 960
             D  C     C+    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1749 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1807

Query: 961  -----FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDD 994
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1808 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1846



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 19/182 (10%)

Query: 1186 EEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAF----EDIYIDQRKTIKTML 1241
            ++ R + W      C R V + WFE   + +ILL+   L      EDI  D ++  + + 
Sbjct: 66   QDSRPRSW------CLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQ 118

Query: 1242 EYADKVFTYIFILEMLLKWVA---YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1298
             + D +F + F +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S  
Sbjct: 119  AFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-- 175

Query: 1299 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
                ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+
Sbjct: 176  --FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1359 AG 1360
            AG
Sbjct: 234  AG 235



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 109  YILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/288 (24%), Positives = 136/288 (47%), Gaps = 45/288 (15%)

Query: 1193 WWNLRRTCFR-IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI 1251
            +W L    FR IV+  +F   I+  IL+++ ++  E  Y +Q + +   LE ++ VFT +
Sbjct: 728  FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSL 785

Query: 1252 FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311
            F LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R
Sbjct: 786  FALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMR 840

Query: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTG 1371
             L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF      +  
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-----ASER 895

Query: 1372 DRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAV 1431
            D   + D                      + NFD++ +  +++ Q+ T + W  ++Y  +
Sbjct: 896  DGDTLPD----------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGM 933

Query: 1432 DSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1479
             S           S +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 934  AS----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 72/272 (26%), Positives = 122/272 (44%), Gaps = 40/272 (14%)

Query: 1527 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRH 1586
            V  + F   IMI I +N ++M +E  +Q E +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 Y-YFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1642
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1643 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1698
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1699 FGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSY 1758
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1759 IIISFLVVVNMYIAVILENFSVATEESAEPLS 1790
            +     V+ N+ +A+++E F        E  S
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 35/104 (33%), Positives = 62/104 (59%), Gaps = 13/104 (12%)

Query: 1402 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1461
            +NFDN+G+ ++++ QV T +GW+DIMY  +D+           S Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1462 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1505
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKIIAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K++  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 79/157 (50%), Gaps = 10/157 (6%)

Query: 754 VMDPFVDLAITICIVLNTLFMAM----EHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKII 809
           V +P+ +    + I+LN + + M    E          +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 810 AMDPY---YYFQEGWNIFDGFIVTLSLVE--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 864
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 865 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 344  QCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 400
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1751 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1805

Query: 401  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1806 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1863



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 55/228 (24%), Positives = 107/228 (46%), Gaps = 43/228 (18%)

Query: 123  KILVHSL-----FSMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 171
            ++LVH L       + I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1583 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1642

Query: 172  KIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 220
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1643 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1698

Query: 221  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQW 280
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF G+L  +C + 
Sbjct: 1699 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF-GDL--ECDET 1755

Query: 281  PPTNASLEEHSIEKNITV------------NYNGTLINETVFEFDWKS 316
             P    L  H+  +N  +            N+NG ++ +T+ + D +S
Sbjct: 1756 HPCE-GLGRHATFRNFGMAFLTLFRVSTGDNWNG-IMKDTLRDCDQES 1801



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 21/166 (12%)

Query: 1532 FDISIMILICLNMVTMM-------VETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL 1584
            F+   M++I LN VT+        +  D Q      IL   +      F  E V+K+++L
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQR---CRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1585 ----RHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIK 1640
                +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1641 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1686
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 40.0 bits (92), Expect = 0.023
 Identities = 25/106 (23%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 364  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG----------KTYMIFFVLVIFLGSFY 413
            +FD    A +SLF L ++D W ++    L A G             +++F+  + + +F+
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 414  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQ 459
            ++N+ + VV   + +  Q   EE  ++  E  + + +L+K++  AQ
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREE--KRLRRLEKKRRKAQ 1571



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1695 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFF 1754
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1755 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1791
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,065,446
Number of Sequences: 37866
Number of extensions: 3110697
Number of successful extensions: 23403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 238
Number of HSP's successfully gapped in prelim test: 365
Number of HSP's that attempted gapping in prelim test: 14953
Number of HSP's gapped (non-prelim): 4802
length of query: 1998
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1881
effective length of database: 13,817,196
effective search space: 25990145676
effective search space used: 25990145676
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.