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Search of human proteins with 115583670
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo
sapiens]
(1591 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 3162 0.0
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 983 0.0
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 497 e-140
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 117 1e-25
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 115 3e-25
gi|71274148 pleckstrin homology domain containing, family G (wit... 109 2e-23
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 109 2e-23
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 109 2e-23
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 100 1e-20
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 95 6e-19
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 95 6e-19
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 88 8e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 87 2e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 86 3e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 86 3e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 85 5e-16
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 82 4e-15
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 82 4e-15
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 80 2e-14
gi|39930351 dynamin binding protein [Homo sapiens] 80 2e-14
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 79 5e-14
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 78 6e-14
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 78 6e-14
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 78 6e-14
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 78 6e-14
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 78 6e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 77 1e-13
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 77 1e-13
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 77 2e-13
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 74 9e-13
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 3162 bits (8199), Expect = 0.0
Identities = 1591/1591 (100%), Positives = 1591/1591 (100%)
Query: 1 MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS 60
MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS
Sbjct: 1 MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS 60
Query: 61 TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA 120
TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA
Sbjct: 61 TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA 120
Query: 121 ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS 180
ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS
Sbjct: 121 ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS 180
Query: 181 LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN 240
LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN
Sbjct: 181 LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN 240
Query: 241 SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG 300
SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG
Sbjct: 241 SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG 300
Query: 301 ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT 360
ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT
Sbjct: 301 ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT 360
Query: 361 TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP 420
TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP
Sbjct: 361 TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP 420
Query: 421 GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD 480
GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD
Sbjct: 421 GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD 480
Query: 481 GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT 540
GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT
Sbjct: 481 GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT 540
Query: 541 AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI 600
AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI
Sbjct: 541 AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI 600
Query: 601 LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS 660
LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS
Sbjct: 601 LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS 660
Query: 661 SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT 720
SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT
Sbjct: 661 SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT 720
Query: 721 EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV 780
EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV
Sbjct: 721 EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV 780
Query: 781 VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP 840
VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP
Sbjct: 781 VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP 840
Query: 841 KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN 900
KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN
Sbjct: 841 KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN 900
Query: 901 RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS 960
RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS
Sbjct: 901 RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS 960
Query: 961 NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS 1020
NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS
Sbjct: 961 NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS 1020
Query: 1021 PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE 1080
PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE
Sbjct: 1021 PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE 1080
Query: 1081 LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK 1140
LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK
Sbjct: 1081 LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK 1140
Query: 1141 LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL 1200
LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL
Sbjct: 1141 LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL 1200
Query: 1201 RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA 1260
RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA
Sbjct: 1201 RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA 1260
Query: 1261 DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL 1320
DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL
Sbjct: 1261 DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL 1320
Query: 1321 SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP 1380
SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP
Sbjct: 1321 SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP 1380
Query: 1381 ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS 1440
ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS
Sbjct: 1381 ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS 1440
Query: 1441 KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK 1500
KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK
Sbjct: 1441 KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK 1500
Query: 1501 ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS 1560
ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS
Sbjct: 1501 ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS 1560
Query: 1561 GINGGLESASEEVIWVRREDFAPSRKLNTEI 1591
GINGGLESASEEVIWVRREDFAPSRKLNTEI
Sbjct: 1561 GINGGLESASEEVIWVRREDFAPSRKLNTEI 1591
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 983 bits (2542), Expect = 0.0
Identities = 594/1351 (43%), Positives = 812/1351 (60%), Gaps = 93/1351 (6%)
Query: 230 NSLGDLYAQKNSGVTANGGP--GSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYN 287
+SL +LY N G + G ++ G +L + + ++ +P A P +
Sbjct: 297 SSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSF 356
Query: 288 TLPCRKSHCLSEGATNP--------QISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGA 339
TLPCRK E +IS R+ + Q+ + EGS++ DS +G
Sbjct: 357 TLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGL 416
Query: 340 TTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSE 399
TD S+ S S S T S+S + D RQ +YENF RELEMS TN+E
Sbjct: 417 NTDVQGSSQASAFLWSGGS--TQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTE 474
Query: 400 SLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATR 459
++E S + E SS +LSS Q D+L QG VRKAG L K + +K +K+E R
Sbjct: 475 NIET--STETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVAR 532
Query: 460 RKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSN 519
RKWK YWV+LKGCTL FYE+ G++ +D +S P+ A++ E+SIVQ+VPEHPKK+ VFCLSN
Sbjct: 533 RKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSN 592
Query: 520 SLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEK 579
S GD +LFQ TSQT+LENW+TA+HSACA+ A+ H KEDTLRLLK++ K L QKIDMD K
Sbjct: 593 SFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSK 652
Query: 580 MKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRL 639
MKKM E+QLS V+D K +K I +QI WEQNLE+F MDLFR RCYLASLQGGELPNPK L
Sbjct: 653 MKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSL 712
Query: 640 LAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGL 699
LA ASRP+K+A+GRLGI SVSSFHALV +R ++ +R+RT ++++ ++ FSSL GL
Sbjct: 713 LAAASRPSKLALGRLGILSVSSFHALVCSRD-DSALRKRTLSLTQRGRNKKGIFSSLKGL 771
Query: 700 DTTSKK-KQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDI 758
DT ++K K+ RPSI QV L I+ V R+ +
Sbjct: 772 DTLARKGKEKRPSITQV---------DELLHIYGSTVDGVPRDNAW----------EIQT 812
Query: 759 WVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQ 818
+VH +N ++P D L L CK QL+ S + L+L+ L+++ ++
Sbjct: 813 YVH---------FQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVE 863
Query: 819 LYVPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSV--EEDGIRRLYVN 876
+P P E + + +Y EIE+ P + + K+ + D +GF++++ E + R++++
Sbjct: 864 YCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCD-FGFAVTAQVDERQHLSRIFIS 922
Query: 877 SVKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPE------- 929
V GLA +GL+ G+EI+ +N A L+ ++ S+ S+GL + P
Sbjct: 923 DVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLC 982
Query: 930 --------LEEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPEET 981
+ L PP++ + L E L N + + + +T
Sbjct: 983 TSWSDSDLFSRDQKSLLPPPNQ----SQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQT 1038
Query: 982 EGP--DLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDAD 1039
+G + ++ + + +S EQ+ A CRS ++ + ++ P R LSDAD
Sbjct: 1039 DGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDAD 1098
Query: 1040 KLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFL 1099
+LRKVI EL++TE++YVKDL+CL E YL+PLQ ETFLTQDE++ LFG+L EM+EFQ FL
Sbjct: 1099 RLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFL 1158
Query: 1100 KTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKA 1159
+TLEDG+ D LE QF+K+LFSLGGSFLYYAD FKLYS FCA+H KV KVL +A
Sbjct: 1159 ETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERA 1218
Query: 1160 KTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDV 1219
KTD AFKAFLDA+NP +QHSSTLESYLIKP+QR+LKYPLLL+EL +LTD ESEEHYHL
Sbjct: 1219 KTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTE 1278
Query: 1220 AIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPP 1279
A+K M KVASHINEMQKI+E++G VFDQL+AEQ+G +KEV +LSMG+LL+H+TV WLNP
Sbjct: 1279 ALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPF 1338
Query: 1280 ASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYE-DWDPFRFRHMIPTE 1338
SLGK +K+ EL FVFK AV+LVYK+ K KKKL + R + D DPF+FR +IP
Sbjct: 1339 LSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPIS 1398
Query: 1339 ALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKH 1398
ALQVR A E N++ E++H KSE EGRPE +F LCCS ES+ + +K + SILR+
Sbjct: 1399 ALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENF 1458
Query: 1399 RRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFT-- 1456
RR +K E LP + RL LK P ++ S S+SL + + + N +T
Sbjct: 1459 RRH-IKCE-LPLEKTC----KDRLVPLKNRVPVSAKLAS--SRSL-KVLKNSSSNEWTGE 1509
Query: 1457 ------IDSDAVSASSPEKESQQPPGGG-----DTDRWVEEQFDLAQYEEQDDIKETDIL 1505
+DSD S SS + S P G T LA + + + IKE+DIL
Sbjct: 1510 TGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFAD-NLIKESDIL 1568
Query: 1506 SD-DDEFCESVKGASVDRDLQERLQATSISQ 1535
SD DD+ ++VK S +D++ + Q IS+
Sbjct: 1569 SDEDDDHRQTVKQGSPTKDIEIQFQRLRISE 1599
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b [Homo
sapiens]
Length = 626
Score = 497 bits (1280), Expect = e-140
Identities = 284/524 (54%), Positives = 359/524 (68%), Gaps = 25/524 (4%)
Query: 1027 PQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFG 1086
P R LSDAD+LRKVI EL++TE++YVKDL+CL E YL+PLQ ETFLTQDE++ LFG
Sbjct: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
Query: 1087 NLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFC 1146
+L EM+EFQ FL+TLEDG+ D LE QF+K+LFSLGGSFLYYAD FKLYS FC
Sbjct: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFC 130
Query: 1147 ASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFAL 1206
A+H KV KVL +AKTD AFKAFLDA+NP +QHSSTLESYLIKP+QR+LKYPLLL+EL +L
Sbjct: 131 ANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSL 190
Query: 1207 TDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGD 1266
TD ESEEHYHL A+K M KVASHINEMQKI+E++G VFDQL+AEQ+G +KEV +LSMG+
Sbjct: 191 TDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGE 250
Query: 1267 LLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYE-D 1325
LL+H+TV WLNP SLGK +K+ EL FVFK AV+LVYK+ K KKKL + R + D
Sbjct: 251 LLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTD 310
Query: 1326 WDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKD 1385
DPF+FR +IP ALQVR A E N++ E++H KSE EGRPE +F LCCS ES+ +
Sbjct: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
Query: 1386 FLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGR 1445
+K + SILR+ RR +K E LP + RL LK P ++ S S+SL +
Sbjct: 371 IVKVIRSILRENFRRH-IKCE-LPLEKTC----KDRLVPLKNRVPVSAKLAS--SRSL-K 421
Query: 1446 RRRRLARNRFT--------IDSDAVSASSPEKESQQPPGGG-----DTDRWVEEQFDLAQ 1492
+ + N +T +DSD S SS + S P G T LA
Sbjct: 422 VLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLAD 481
Query: 1493 YEEQDDIKETDILSD-DDEFCESVKGASVDRDLQERLQATSISQ 1535
+ + + IKE+DILSD DD+ ++VK S +D++ + Q IS+
Sbjct: 482 FAD-NLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISE 524
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 117 bits (292), Expect = 1e-25
Identities = 115/410 (28%), Positives = 193/410 (47%), Gaps = 48/410 (11%)
Query: 1013 NPSDQSP---SPQDSTGPQLATMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLK 1068
+P ++P +P GP A R+ +LR V+ E+L TER YV L L +L
Sbjct: 19 HPDPRAPGAAAPSSGPGP-CAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLH 77
Query: 1069 PLQK------ETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFK 1122
+++ E LT++ + VLF N+ +++E +FL LE + P +
Sbjct: 78 RIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQH-------- 129
Query: 1123 KVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDA---QNPKQQHS 1179
LG FL + D+F +Y +C++H K ++LV+ +AFL + ++
Sbjct: 130 ----ELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTD 185
Query: 1180 STLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHE 1239
LE YL+ PIQRI KYPLLL+EL T + +H + A++ M V S+INE ++ E
Sbjct: 186 IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME 245
Query: 1240 EFGAVFDQLIAEQTG-EKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKT 1298
+ A+ +QL + G E + D+ LLL T++ + S G + E A F+F
Sbjct: 246 KLEAL-EQLQSHIEGWEGSNLTDICT-QLLLQGTLLKI----SAGNIQ---ERAFFLFDN 296
Query: 1299 AVVLVYK----DGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANA 1354
+V + GSK+ K S S+Y FR I TE ++V + A+ ++
Sbjct: 297 LLVYCKRKSRVTGSKKSTKRTKSINGSLY------IFRGRINTEVMEVENVEDGTADYHS 350
Query: 1355 VCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLK 1404
V + + + +C + K K + +I+R++ +R+ LK
Sbjct: 351 NGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQ--KWLDAIIREREQRESLK 398
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 115 bits (289), Expect = 3e-25
Identities = 87/299 (29%), Positives = 140/299 (46%), Gaps = 21/299 (7%)
Query: 1011 EMNPSDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLNCLMERYLKP 1069
E PSD D L R L + D++R VI E++ TER Y+K L + E YLK
Sbjct: 73 EEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQ 132
Query: 1070 LQKETFLTQDE-LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSL 1128
+K + DE L V+FGN+ ++ FQ+ F++ DLEK D L +
Sbjct: 133 CRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVR----------DLEKQYNNDD--PHLSEI 180
Query: 1129 GGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSS-TLESYLI 1187
G FL + D F +YS +C +H L K D+ ++ F +A QQ ++ +L+
Sbjct: 181 GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240
Query: 1188 KPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQ 1247
P+Q+I KYPL L EL T + ++ ++ A+ M V INE ++ E +
Sbjct: 241 TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300
Query: 1248 LIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKD 1306
+ E +++ D S +L+ + W+ P + + + F+F +VL KD
Sbjct: 301 QASVLDWEGEDILDRS-SELIYTGEMAWIYQP-----YGRNQQRVFFLFDHQMVLCKKD 353
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 109 bits (273), Expect = 2e-23
Identities = 78/232 (33%), Positives = 120/232 (51%), Gaps = 20/232 (8%)
Query: 1043 KVICELLETERTYVKDLNCLMERYLKPLQKETFLT--QDELDVLFGNLTEMVEFQVEFLK 1100
+V+ E+LETERTYV+DL ++E YL ++ +T L +E LFGN+ ++ F E L+
Sbjct: 116 RVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQ 175
Query: 1101 TLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAK 1160
DLE E ++ F+ ++ F +Y+ +C ++ + VL +
Sbjct: 176 ----------DLENCENDP------VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECM 219
Query: 1161 TDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVA 1220
+ F + +HS L SYL+KP+QRILKY LLL E+ D ++E + + A
Sbjct: 220 RNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDA 279
Query: 1221 IKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTT 1272
I TM +VA HIN+M++ HE AV Q I K S G+L+L T
Sbjct: 280 IDTMQRVAWHINDMKRKHEH--AVRLQEIQSLLTNWKGPDLTSYGELVLEGT 329
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 109 bits (272), Expect = 2e-23
Identities = 100/395 (25%), Positives = 193/395 (48%), Gaps = 42/395 (10%)
Query: 1022 QDSTGPQLA-TMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLKPLQK------E 1073
+DS G A + + L +LR V+ EL +TER YV L L+ +L + + +
Sbjct: 3 EDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVD 62
Query: 1074 TFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFL 1133
+T++ + +LF N+ +++ EFLK +E+ + P+ ++ +G FL
Sbjct: 63 KNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFL 110
Query: 1134 YYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFL---DAQNPKQQHSSTLESYLIKPI 1190
++ D+F++Y +C++H K K+L++ + FL ++ LE YL+ PI
Sbjct: 111 HFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPI 170
Query: 1191 QRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIA 1250
QRI KYPL+L+EL T + ++ + A++ M V S+INE ++ E+ + +
Sbjct: 171 QRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSH 230
Query: 1251 EQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ 1310
+ E + D + ++L+ ++ + S G + E F+F +LVY K+
Sbjct: 231 IEGWEGSNITD-TCTEMLMCGVLLKI----SSGNIQ---ERVFFLFDN--LLVY---CKR 277
Query: 1311 KKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPE 1370
K + + + + S D + FR I TE ++V + A+ ++ IV + +
Sbjct: 278 KHRRLKNSKAS--TDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAK 335
Query: 1371 RVFHLC-CSSPESRKDFLKAVHSILRDKHRRQLLK 1404
+ +C +PE + ++ +A IL+++ RR+ LK
Sbjct: 336 NKWFVCMAKTPEEKHEWFEA---ILKERERRKGLK 367
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 109 bits (272), Expect = 2e-23
Identities = 100/395 (25%), Positives = 193/395 (48%), Gaps = 42/395 (10%)
Query: 1022 QDSTGPQLA-TMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLKPLQK------E 1073
+DS G A + + L +LR V+ EL +TER YV L L+ +L + + +
Sbjct: 3 EDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVD 62
Query: 1074 TFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFL 1133
+T++ + +LF N+ +++ EFLK +E+ + P+ ++ +G FL
Sbjct: 63 KNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFL 110
Query: 1134 YYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFL---DAQNPKQQHSSTLESYLIKPI 1190
++ D+F++Y +C++H K K+L++ + FL ++ LE YL+ PI
Sbjct: 111 HFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPI 170
Query: 1191 QRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIA 1250
QRI KYPL+L+EL T + ++ + A++ M V S+INE ++ E+ + +
Sbjct: 171 QRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSH 230
Query: 1251 EQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ 1310
+ E + D + ++L+ ++ + S G + E F+F +LVY K+
Sbjct: 231 IEGWEGSNITD-TCTEMLMCGVLLKI----SSGNIQ---ERVFFLFDN--LLVY---CKR 277
Query: 1311 KKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPE 1370
K + + + + S D + FR I TE ++V + A+ ++ IV + +
Sbjct: 278 KHRRLKNSKAS--TDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAK 335
Query: 1371 RVFHLC-CSSPESRKDFLKAVHSILRDKHRRQLLK 1404
+ +C +PE + ++ +A IL+++ RR+ LK
Sbjct: 336 NKWFVCMAKTPEEKHEWFEA---ILKERERRKGLK 367
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 100 bits (248), Expect = 1e-20
Identities = 77/295 (26%), Positives = 136/295 (46%), Gaps = 22/295 (7%)
Query: 1015 SDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLNCLMERYLKPLQKE 1073
S +PS + + R + ++R VI E+++TER Y+K L + E Y++ +K
Sbjct: 214 SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
Query: 1074 T-FLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSF 1132
T T +L +FGN+ ++ +FQ +FLK LE ++ ++ + L +G F
Sbjct: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE------------KQYNKEEPHLSEIGSCF 321
Query: 1133 LYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSS-TLESYLIKPIQ 1191
L + F +YS +C +H L ++ F +A QQ ++ +L+ P+Q
Sbjct: 322 LQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQ 381
Query: 1192 RILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAE 1251
+I KYPL L EL T E ++ ++ A + M VA INE ++ E + ++
Sbjct: 382 KICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSI 441
Query: 1252 QTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKD 1306
E ++ D S L+H+ + + K K + F+F +V KD
Sbjct: 442 VGWEGLDILDRS--SELIHSGEL-----TKITKQGKSQQRTFFLFDHQLVSCKKD 489
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [Homo
sapiens]
Length = 690
Score = 94.7 bits (234), Expect = 6e-19
Identities = 65/238 (27%), Positives = 118/238 (49%), Gaps = 16/238 (6%)
Query: 1003 AAFCR-SLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLN 1060
A+F R +++ P+D ++G + S D++R VI E+L TER Y+K L
Sbjct: 245 ASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLR 304
Query: 1061 CLMERYLKPLQKET-FLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVD 1119
+ E Y++ +K ++++L +FGN+ ++ Q F+K LE ++ +
Sbjct: 305 DICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALE------------QRFN 352
Query: 1120 QFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHS 1179
+ + L LG FL + F++YS +C +H L + + + F +A Q+
Sbjct: 353 RERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI 412
Query: 1180 S-TLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQK 1236
+L+ +L+ P+Q+I KYPL L EL T + + ++ A+ M VA INE ++
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKR 470
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [Homo
sapiens]
Length = 670
Score = 94.7 bits (234), Expect = 6e-19
Identities = 65/238 (27%), Positives = 118/238 (49%), Gaps = 16/238 (6%)
Query: 1003 AAFCR-SLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLN 1060
A+F R +++ P+D ++G + S D++R VI E+L TER Y+K L
Sbjct: 245 ASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLR 304
Query: 1061 CLMERYLKPLQKET-FLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVD 1119
+ E Y++ +K ++++L +FGN+ ++ Q F+K LE ++ +
Sbjct: 305 DICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALE------------QRFN 352
Query: 1120 QFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHS 1179
+ + L LG FL + F++YS +C +H L + + + F +A Q+
Sbjct: 353 RERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI 412
Query: 1180 S-TLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQK 1236
+L+ +L+ P+Q+I KYPL L EL T + + ++ A+ M VA INE ++
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKR 470
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 87.8 bits (216), Expect = 8e-17
Identities = 135/536 (25%), Positives = 217/536 (40%), Gaps = 78/536 (14%)
Query: 893 DEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPP------HRVDG 946
DE +E R + L+S L S G+ E EEG + + PP H +
Sbjct: 1827 DETVEERGRN-EGLSSGTLS---KSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQ 1882
Query: 947 PADLGESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFC 1006
P + + L P SE S+AE E + + E SS +Q +
Sbjct: 1883 PDSQDDKASSRLLVRP---TSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDS-- 1937
Query: 1007 RSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066
S NPSD S S ++ R+ S + V+ EL+ETER YV+DL ++E Y
Sbjct: 1938 -SSPSFNPSDNSLLSSSSPIDEMEE-RKSSSLKRRHYVLQELVETERDYVRDLGYVVEGY 1995
Query: 1067 LKPLQKETFLTQD---ELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
+ L KE + D + ++FGN+ ++ ++ +F L + + + D EKL
Sbjct: 1996 MA-LMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFF--LGELEKCLEDPEKL-------- 2044
Query: 1124 VLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLE 1183
G F+ + R +Y A+C + K + V DT F + + H L
Sbjct: 2045 -----GSLFVKHERRLHMYIAYCQNKPKSEHI-VSEYIDT----FFEDLKQRLGHRLQLT 2094
Query: 1184 SYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGA 1243
LIKP+QRI+KY LLL++ + S + L+ A++ M V N+M + G
Sbjct: 2095 DLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQG- 2153
Query: 1244 VFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLV 1303
FD I Q G LLL T + + A L +E + F+F+ V+
Sbjct: 2154 -FDGKIVAQ------------GKLLLQDTFLVTDQDAGLLPRCRERRI--FLFEQIVIFS 2198
Query: 1304 YKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKS 1363
K+ + G F F++ +++V L + N C+ +
Sbjct: 2199 EPLDKKKGFSMPG------------FLFKN-----SIKVSCLCLEENVENDPCKF--ALT 2239
Query: 1364 ESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGG 1419
G F L SSP R+ ++ ++ IL +++R L + P Q GG
Sbjct: 2240 SRTGDVVETFILHSSSPSVRQTWIHEINQIL--ENQRNFLNALTSPIEYQRNHSGG 2293
Score = 79.3 bits (194), Expect = 3e-14
Identities = 87/345 (25%), Positives = 150/345 (43%), Gaps = 56/345 (16%)
Query: 1044 VICELLETERTYVKDLNCLMERYLKPLQKETF-----LTQDELDVLFGNLTEMVEFQVEF 1098
++ EL++TE+ YV+DL M+ YL + + EL ++FGN+ E+ EF
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKEL-IIFGNMQEIYEFHNNI 1354
Query: 1099 LKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVK 1158
L++LEK +Q + +G F+ +AD+F++Y +C + +++++
Sbjct: 1355 F------------LKELEKYEQLPE---DVGHCFVTWADKFQMYVTYCKNKPDSTQLILE 1399
Query: 1159 AKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
++ D + ++++ SYLIKP+QRI KY LLL+EL + E +
Sbjct: 1400 HAG-----SYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE---IK 1451
Query: 1219 VAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTV-IWLN 1277
++ M V N+ +H FD+ I Q G+L+L + +W
Sbjct: 1452 DGLEVMLSVPKRAND--AMHLSMLEGFDENIESQ------------GELILQESFQVW-- 1495
Query: 1278 PPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGS----HRLSIYE--DWDPFRF 1331
P +L + +E L F KD S + K L S L + E + DP +F
Sbjct: 1496 DPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKF 1555
Query: 1332 RHMI-PTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHL 1375
+ T + + A + N I H++ E ER HL
Sbjct: 1556 ALWVGRTPTSDNKIVLKASSIENKQDWIKHIR---EVIQERTIHL 1597
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 86.7 bits (213), Expect = 2e-16
Identities = 62/207 (29%), Positives = 105/207 (50%), Gaps = 27/207 (13%)
Query: 1040 KLRKVICELLETERTYVKDLNCLMERYLKPLQKETFL--TQDELDVLFGNLTEMVEFQVE 1097
+L +V E++ETER YV+DL ++E YL PL L + +++ LF N+ ++ EF E
Sbjct: 102 RLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE 161
Query: 1098 FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGG---SFLYYADRFKLYSAFCASHTKVPK 1154
L+ LE+ S GG F+ ++ F +Y+ +C ++
Sbjct: 162 LLEDLENSS--------------------SAGGIAECFVQRSEDFDIYTLYCMNYPSSLA 201
Query: 1155 VLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLREL--FALTDAESE 1212
+L + +L + + +HS L+S+L+KP+QRILKY LLL+EL +
Sbjct: 202 LLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTG 261
Query: 1213 EHYHLDVAIKTMNKVASHINEMQKIHE 1239
++ AI +M VA +IN+M++ E
Sbjct: 262 GREMVEEAIVSMTAVAWYINDMKRKQE 288
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 85.9 bits (211), Expect = 3e-16
Identities = 85/322 (26%), Positives = 143/322 (44%), Gaps = 21/322 (6%)
Query: 988 SSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQ-LATMRQLSDADKLRKVIC 1046
+ D+ D V S + +D PS Q Q L TM+ + K + I
Sbjct: 1131 NKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIER--KRQGYIH 1188
Query: 1047 ELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGV 1106
EL++TE Y+ DL ++E + K + + FLT+ E+ ++F N E++ + LK L V
Sbjct: 1189 ELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALR--V 1246
Query: 1107 RLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLV-KAKTDTAF 1165
R +K K + +G + Y FC+ +L K DT F
Sbjct: 1247 R--------KKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDF 1298
Query: 1166 KAFLD--AQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKT 1223
K FL A +P+ + L S+L+KP+QRI +YPLL+R + T +H L +A++
Sbjct: 1299 KEFLKKLASDPRCK-GMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALER 1357
Query: 1224 MNKVASHINEMQKIHEEFGAV-FDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASL 1282
++ S +NE + E + + Q + G +++ S+ + L ++ L
Sbjct: 1358 AEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLL---HSGKL 1414
Query: 1283 GKWKKEPELAAFVFKTAVVLVY 1304
K K EL F+F ++L Y
Sbjct: 1415 YKTKSNKELHGFLFNDFLLLTY 1436
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 85.9 bits (211), Expect = 3e-16
Identities = 85/322 (26%), Positives = 143/322 (44%), Gaps = 21/322 (6%)
Query: 988 SSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQ-LATMRQLSDADKLRKVIC 1046
+ D+ D V S + +D PS Q Q L TM+ + K + I
Sbjct: 1158 NKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIER--KRQGYIH 1215
Query: 1047 ELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGV 1106
EL++TE Y+ DL ++E + K + + FLT+ E+ ++F N E++ + LK L V
Sbjct: 1216 ELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALR--V 1273
Query: 1107 RLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLV-KAKTDTAF 1165
R +K K + +G + Y FC+ +L K DT F
Sbjct: 1274 R--------KKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDF 1325
Query: 1166 KAFLD--AQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKT 1223
K FL A +P+ + L S+L+KP+QRI +YPLL+R + T +H L +A++
Sbjct: 1326 KEFLKKLASDPRCK-GMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALER 1384
Query: 1224 MNKVASHINEMQKIHEEFGAV-FDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASL 1282
++ S +NE + E + + Q + G +++ S+ + L ++ L
Sbjct: 1385 AEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLL---HSGKL 1441
Query: 1283 GKWKKEPELAAFVFKTAVVLVY 1304
K K EL F+F ++L Y
Sbjct: 1442 YKTKSNKELHGFLFNDFLLLTY 1463
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 85.1 bits (209), Expect = 5e-16
Identities = 65/224 (29%), Positives = 111/224 (49%), Gaps = 19/224 (8%)
Query: 1015 SDQSPSPQDSTGPQLATMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLKPLQKE 1073
+D PS Q + L M L+ ++ R+ I EL+ TE YV DL + E + KPL +
Sbjct: 1213 TDMDPSQQWCSDLHLLDM--LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMES 1270
Query: 1074 TFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFL 1133
LT+ E+ ++F N E++ ++ LK L VR +K+ K + +G
Sbjct: 1271 ELLTEKEVAMIFVNWKELIMCNIKLLKALR--VR--------KKMSGEKMPVKMIGDILS 1320
Query: 1134 YYADRFKLYSAFCASHTKVPKVLVKAKTDTA--FKAFLD--AQNPKQQHSSTLESYLIKP 1189
+ Y FC+ L++ KTD A FK F+ A +P+ + L S+++KP
Sbjct: 1321 AQLPHMQPYIRFCSRQLN-GAALIQQKTDEAPDFKEFVKRLAMDPRCK-GMPLSSFILKP 1378
Query: 1190 IQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINE 1233
+QR+ +YPL+++ + T +H HL A++ ++ S +NE
Sbjct: 1379 MQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNE 1422
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 82.0 bits (201), Expect = 4e-15
Identities = 70/227 (30%), Positives = 106/227 (46%), Gaps = 35/227 (15%)
Query: 984 PDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK 1043
P + E S + + R+ EM+ S Q LA +R R
Sbjct: 610 PGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILR--------RH 661
Query: 1044 VICELLETERTYVKDLNCLMERYL----KPLQKETFLT--QDELDVLFGNLTEMVEFQVE 1097
V+ ELL+TER YV++L C++E Y PL T ++ DVLFGN+ E+ F
Sbjct: 662 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 721
Query: 1098 -FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVL 1156
FL+ LE+ P+L +G FL + F++Y +C + + + L
Sbjct: 722 IFLRELENYTDC-PEL---------------VGRCFLERMEDFQIYEKYCQNKPR-SESL 764
Query: 1157 VKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLREL 1203
+ +D F F + Q K H +L+SYL+KP+QRI KY LLL+E+
Sbjct: 765 WRQCSDCPF--FQECQR-KLDHKLSLDSYLLKPVQRITKYQLLLKEM 808
Score = 31.2 bits (69), Expect = 8.4
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 6/71 (8%)
Query: 358 SPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTL 417
SP SSS G A R+G Y + E+ SES + GSA +E+S L
Sbjct: 605 SPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEM------SESRQGRGSAGEEEESLAIL 658
Query: 418 SSPGQSDILLT 428
S++L T
Sbjct: 659 RRHVMSELLDT 669
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 82.0 bits (201), Expect = 4e-15
Identities = 70/227 (30%), Positives = 106/227 (46%), Gaps = 35/227 (15%)
Query: 984 PDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK 1043
P + E S + + R+ EM+ S Q LA +R R
Sbjct: 557 PGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILR--------RH 608
Query: 1044 VICELLETERTYVKDLNCLMERYL----KPLQKETFLT--QDELDVLFGNLTEMVEFQVE 1097
V+ ELL+TER YV++L C++E Y PL T ++ DVLFGN+ E+ F
Sbjct: 609 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 668
Query: 1098 -FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVL 1156
FL+ LE+ P+L +G FL + F++Y +C + + + L
Sbjct: 669 IFLRELENYTDC-PEL---------------VGRCFLERMEDFQIYEKYCQNKPR-SESL 711
Query: 1157 VKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLREL 1203
+ +D F F + Q K H +L+SYL+KP+QRI KY LLL+E+
Sbjct: 712 WRQCSDCPF--FQECQR-KLDHKLSLDSYLLKPVQRITKYQLLLKEM 755
Score = 31.2 bits (69), Expect = 8.4
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 6/71 (8%)
Query: 358 SPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTL 417
SP SSS G A R+G Y + E+ SES + GSA +E+S L
Sbjct: 552 SPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEM------SESRQGRGSAGEEEESLAIL 605
Query: 418 SSPGQSDILLT 428
S++L T
Sbjct: 606 RRHVMSELLDT 616
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 80.1 bits (196), Expect = 2e-14
Identities = 58/209 (27%), Positives = 105/209 (50%), Gaps = 21/209 (10%)
Query: 1034 QLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVE 1093
++++ DK + E+ +TE Y L + + +LKPLQ+ FL +++++F N+ +++
Sbjct: 188 KMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR--FLKPQDIEIIFINIEDLLR 245
Query: 1094 FQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVP 1153
FLK +++ + P L +V F+ Y +RF +Y +C+
Sbjct: 246 VHTHFLKEMKEALG-TPGAANLYQV-------------FIKYKERFLVYGRYCSQVESAS 291
Query: 1154 KVLVK---AKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAE 1210
K L + A+ D K +Q TL L+ P+QR+LKY LLL+EL T E
Sbjct: 292 KHLDRVAAAREDVQMKLEECSQRANNGRF-TLRDLLMVPMQRVLKYHLLLQELVKHTQ-E 349
Query: 1211 SEEHYHLDVAIKTMNKVASHINEMQKIHE 1239
+ E +L +A+ M +A +NE+++ +E
Sbjct: 350 AMEKENLRLALDAMRDLAQCVNEVKRDNE 378
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 79.7 bits (195), Expect = 2e-14
Identities = 70/269 (26%), Positives = 121/269 (44%), Gaps = 32/269 (11%)
Query: 979 EETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNP-SDQSPSPQDSTGPQLATMRQLSD 1037
++ E E+ ++ + E + + L EM S QS S +G A +
Sbjct: 722 KQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRM 781
Query: 1038 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVE 1097
+K KVI ELL+TER Y++DL +ER + P+Q+ D + LFGN+ +++ +
Sbjct: 782 LEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-FEGLFGNMQMVIKVSKQ 840
Query: 1098 FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVL 1156
L LE + ++G FL + D + Y +C +H + +L
Sbjct: 841 LLAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALL 880
Query: 1157 VKAKTDTAFKAFL-----DAQNPKQQHSST----LESYLIKPIQRILKYPLLLRELFALT 1207
+ D + L D ++ + T L S+LIKP+QR+++YPLLL EL T
Sbjct: 881 EIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNST 940
Query: 1208 DAESEEHYHLDVAIKTMNKVASHINEMQK 1236
+ L A+ + ++ +INE ++
Sbjct: 941 PESHPDKVPLTNAVLAVKEINVNINEYKR 969
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 [Homo
sapiens]
Length = 847
Score = 78.6 bits (192), Expect = 5e-14
Identities = 69/272 (25%), Positives = 128/272 (47%), Gaps = 29/272 (10%)
Query: 1045 ICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLED 1104
+ E+ +TE Y + L + + ++ PL++ FLT E D +F N+ E+V+ ++ + D
Sbjct: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
Query: 1105 GVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCAS-HTKVPKVLVKAKTDT 1163
+ + K DQ +L F+ Y +R +Y +C+ + + + +KT
Sbjct: 255 SI--------VNKNDQ------NLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
Query: 1164 AFKAFLDAQNPKQQHSS-TLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIK 1222
K L+ + + + TL L+ P+QR+LKY LLL+EL T + E +L +A+
Sbjct: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALD 359
Query: 1223 TMNKVASHINEMQKIHEEFGAVFD-QLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPAS 1281
M +A ++NE+++ +E + QL E + + GD + T +
Sbjct: 360 AMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRIT--------T 411
Query: 1282 LGKWKKEPELAAFVFKTAVVLVYKDGSKQKKK 1313
L K K+ E F+F AV++ + G + K
Sbjct: 412 LDKHTKQ-ERHIFLFDLAVIVCKRKGDNYEMK 442
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 78.2 bits (191), Expect = 6e-14
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 29/216 (13%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK-----VICELLETERTYVKDLNCLM 1063
+ E+ S++ SP+ T L + + D + K V+ +LETE Y K+L ++
Sbjct: 60 VREVKASEKPVSPKSGT---LKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVL 116
Query: 1064 ERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
YL+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 117 STYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ--------- 166
Query: 1124 VLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTL 1182
+GG FL + K LY +CA+H VL + + F++ + L
Sbjct: 167 ---RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVL 221
Query: 1183 ESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
+ L KP R+ KYP LL+EL E YH D
Sbjct: 222 TTGLSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 252
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 6e-14
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 29/216 (13%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK-----VICELLETERTYVKDLNCLM 1063
+ E+ S++ SP+ T L + + D + K V+ +LETE Y K+L ++
Sbjct: 188 VREVKASEKPVSPKSGT---LKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVL 244
Query: 1064 ERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
YL+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 245 STYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ--------- 294
Query: 1124 VLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTL 1182
+GG FL + K LY +CA+H VL + + F++ + L
Sbjct: 295 ---RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVL 349
Query: 1183 ESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
+ L KP R+ KYP LL+EL E YH D
Sbjct: 350 TTGLSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 380
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 78.2 bits (191), Expect = 6e-14
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 29/216 (13%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK-----VICELLETERTYVKDLNCLM 1063
+ E+ S++ SP+ T L + + D + K V+ +LETE Y K+L ++
Sbjct: 238 VREVKASEKPVSPKSGT---LKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVL 294
Query: 1064 ERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
YL+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 295 STYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ--------- 344
Query: 1124 VLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTL 1182
+GG FL + K LY +CA+H VL + + F++ + L
Sbjct: 345 ---RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVL 399
Query: 1183 ESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
+ L KP R+ KYP LL+EL E YH D
Sbjct: 400 TTGLSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 430
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 78.2 bits (191), Expect = 6e-14
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 29/216 (13%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK-----VICELLETERTYVKDLNCLM 1063
+ E+ S++ SP+ T L + + D + K V+ +LETE Y K+L ++
Sbjct: 217 VREVKASEKPVSPKSGT---LKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVL 273
Query: 1064 ERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
YL+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 274 STYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ--------- 323
Query: 1124 VLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTL 1182
+GG FL + K LY +CA+H VL + + F++ + L
Sbjct: 324 ---RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVL 378
Query: 1183 ESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
+ L KP R+ KYP LL+EL E YH D
Sbjct: 379 TTGLSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 409
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 78.2 bits (191), Expect = 6e-14
Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 29/216 (13%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRK-----VICELLETERTYVKDLNCLM 1063
+ E+ S++ SP+ T L + + D + K V+ +LETE Y K+L ++
Sbjct: 60 VREVKASEKPVSPKSGT---LKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVL 116
Query: 1064 ERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKK 1123
YL+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 117 STYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ--------- 166
Query: 1124 VLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTL 1182
+GG FL + K LY +CA+H VL + + F++ + L
Sbjct: 167 ---RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVL 221
Query: 1183 ESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
+ L KP R+ KYP LL+EL E YH D
Sbjct: 222 TTGLSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 252
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 77.0 bits (188), Expect = 1e-13
Identities = 90/356 (25%), Positives = 151/356 (42%), Gaps = 66/356 (18%)
Query: 1038 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKET------FLTQDELDVLFGNLTEM 1091
A K ++ ELL+TE+ YV+DL+ +E YL + L ++ ++FGN+ E+
Sbjct: 1279 ARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEH--IIFGNIQEI 1336
Query: 1092 VEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTK 1151
+F L++LEK +Q + +G F+ +AD+F++Y +C +
Sbjct: 1337 YDFHNNIF------------LKELEKYEQLPE---DVGHCFVTWADKFQMYVTYCKNKPD 1381
Query: 1152 VPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAES 1211
+++++ F D + ++++ SYLIKP+QRI KY LLL+EL +
Sbjct: 1382 SNQLILEHAG-----TFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGK 1436
Query: 1212 EEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHT 1271
E L ++ M V N+ +H FD+ + Q G+L+L
Sbjct: 1437 GE---LKDGLEVMLSVPKKAND--AMHVSMLEGFDENLDVQ------------GELILQD 1479
Query: 1272 TV-IWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ-----KKKLVGSH-RLSIYE 1324
+W P SL + +E L F KD S K KL+ S ++ +
Sbjct: 1480 AFQVW--DPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHV 1537
Query: 1325 DWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSE-----SEGRPERVFHL 1375
+ DP +F AL S+D + + K E E ER+ HL
Sbjct: 1538 EGDPCKF-------ALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHL 1586
Score = 70.1 bits (170), Expect = 2e-11
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 72/391 (18%)
Query: 1044 VICELLETERTYVKDLNCLMERYLKPLQK----ETFLTQDELDVLFGNLTEMVEFQVEFL 1099
V+ EL++TE+ YVKDL ++E ++K +++ E +D+ ++FGN+ ++ ++ +F
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDK--IVFGNIHQIYDWHKDFF 1990
Query: 1100 KTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKA 1159
L +LEK Q + L L F+ + + +Y +C + + ++ +
Sbjct: 1991 ------------LAELEKCIQEQDRLAQL---FIKHERKLHIYVWYCQNKPRSEYIVAE- 2034
Query: 1160 KTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDV 1219
+ A+ + + TL +LIKPIQRI KY LLL++ ++ E ++
Sbjct: 2035 -----YDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEK 2089
Query: 1220 AIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPP 1279
A++ M V N+M + G F+ + Q G LL T +
Sbjct: 2090 AVELMCLVPKRCNDMMNLGRLQG--FEGTLTAQ------------GKLLQQDTFYVIELD 2135
Query: 1280 ASLGKWKKEPELAAFVFKTAVVL--VYKDGSKQK----KKLVGSHRLSIYE--DWDPFRF 1331
A G + E F+F+ V+ + + GS K+ + + L + E D DP +F
Sbjct: 2136 A--GMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKF 2193
Query: 1332 RHM-IPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAV 1390
M T V A+AD + V +I V E+++DFL A+
Sbjct: 2194 ALMNRETSERVVLQAANADIQQAWVQDINQVL------------------ETQRDFLNAL 2235
Query: 1391 HSILRDKHRRQLLKTESLPSSQQYVPFGGKR 1421
S + +++R+ T + S +P R
Sbjct: 2236 QSPI--EYQRKERSTAVMRSQPARLPQASPR 2264
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 77.0 bits (188), Expect = 1e-13
Identities = 90/356 (25%), Positives = 151/356 (42%), Gaps = 66/356 (18%)
Query: 1038 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKET------FLTQDELDVLFGNLTEM 1091
A K ++ ELL+TE+ YV+DL+ +E YL + L ++ ++FGN+ E+
Sbjct: 1279 ARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEH--IIFGNIQEI 1336
Query: 1092 VEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTK 1151
+F L++LEK +Q + +G F+ +AD+F++Y +C +
Sbjct: 1337 YDFHNNIF------------LKELEKYEQLPE---DVGHCFVTWADKFQMYVTYCKNKPD 1381
Query: 1152 VPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAES 1211
+++++ F D + ++++ SYLIKP+QRI KY LLL+EL +
Sbjct: 1382 SNQLILEHAG-----TFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGK 1436
Query: 1212 EEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHT 1271
E L ++ M V N+ +H FD+ + Q G+L+L
Sbjct: 1437 GE---LKDGLEVMLSVPKKAND--AMHVSMLEGFDENLDVQ------------GELILQD 1479
Query: 1272 TV-IWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ-----KKKLVGSH-RLSIYE 1324
+W P SL + +E L F KD S K KL+ S ++ +
Sbjct: 1480 AFQVW--DPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHV 1537
Query: 1325 DWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSE-----SEGRPERVFHL 1375
+ DP +F AL S+D + + K E E ER+ HL
Sbjct: 1538 EGDPCKF-------ALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHL 1586
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 76.6 bits (187), Expect = 2e-13
Identities = 61/229 (26%), Positives = 104/229 (45%), Gaps = 20/229 (8%)
Query: 1009 LHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLK 1068
+ E+ S++ SP+ G + A + + + V+ +L+TE+ Y K+L L+ YL+
Sbjct: 214 VREIKSSERPLSPKAVKGFETAPLTK----NYYTVVLQNILDTEKEYAKELQSLLVTYLR 269
Query: 1069 PLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSL 1128
PLQ L+ E+ L GN E+ FQ +TL + LE+ +F + +
Sbjct: 270 PLQSNNNLSTVEVTSLLGNFEEVCTFQ----QTL---------CQALEECSKFPENQHKV 316
Query: 1129 GGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLI 1187
GG L FK +Y A+CA+H VL + + + F++ Q L + L
Sbjct: 317 GGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE--LEQFMENQGASSPGILILTTNLS 374
Query: 1188 KPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQK 1236
KP R+ KY LL+EL + +H + AI + +++K
Sbjct: 375 KPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRK 423
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 74.3 bits (181), Expect = 9e-13
Identities = 65/218 (29%), Positives = 113/218 (51%), Gaps = 30/218 (13%)
Query: 1024 STGPQLATMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLKPLQK-ETF-----L 1076
S+GP +++ + D L+ V+ EL++TER YV++L ++ Y + E F L
Sbjct: 539 SSGPS-SSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPL 597
Query: 1077 TQDELDVLFGNLTEMVEFQVE-FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYY 1135
+++ D+LFGN+ E+ EF + FL +LE+ P+ +G FL
Sbjct: 598 LRNKKDILFGNMAEIYEFHNDIFLSSLENCAH-APE---------------RVGPCFLER 641
Query: 1136 ADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILK 1195
D F++Y+ +C + + + + + ++ AF F + Q K +H L+SYL+KP+QRI K
Sbjct: 642 KDDFQMYAKYCQNKPR-SETIWRKYSECAF--FQECQR-KLKHRLRLDSYLLKPVQRITK 697
Query: 1196 YPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINE 1233
Y LLL+EL + + E L A+ M + +N+
Sbjct: 698 YQLLLKELLKYS-KDCEGSALLKKALDAMLDLLKSVND 734
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,859,631
Number of Sequences: 37866
Number of extensions: 2818916
Number of successful extensions: 9551
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 176
Number of HSP's that attempted gapping in prelim test: 8481
Number of HSP's gapped (non-prelim): 964
length of query: 1591
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1475
effective length of database: 13,855,062
effective search space: 20436216450
effective search space used: 20436216450
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.