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Search of human proteins with 115583667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115583667 sodium channel, voltage-gated, type XI, alpha
[Homo sapiens]
(1791 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 3613 0.0
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 1605 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 1375 0.0
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 1375 0.0
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 1375 0.0
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 1369 0.0
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 1333 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 1332 0.0
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 1314 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 1302 0.0
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 1302 0.0
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 1302 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 1301 0.0
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 1292 0.0
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 1292 0.0
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 1292 0.0
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 1281 0.0
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 1278 0.0
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 1163 0.0
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 782 0.0
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 354 5e-97
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 354 5e-97
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 353 8e-97
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 350 7e-96
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 350 9e-96
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 3613 bits (9369), Expect = 0.0
Identities = 1791/1791 (100%), Positives = 1791/1791 (100%)
Query: 1 MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASR 60
MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASR
Sbjct: 1 MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASR 60
Query: 61 KLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRS 120
KLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRS
Sbjct: 61 KLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRS 120
Query: 121 LAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILA 180
LAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILA
Sbjct: 121 LAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILA 180
Query: 181 RGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLK 240
RGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLK
Sbjct: 181 RGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLK 240
Query: 241 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC 300
VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC
Sbjct: 241 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC 300
Query: 301 FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS 360
FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS
Sbjct: 301 FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS 360
Query: 361 WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM 420
WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM
Sbjct: 361 WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM 420
Query: 421 FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPP 480
FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPP
Sbjct: 421 FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPP 480
Query: 481 GSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQ 540
GSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQ
Sbjct: 481 GSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQ 540
Query: 541 EPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK 600
EPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK
Sbjct: 541 EPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK 600
Query: 601 MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCV 660
MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCV
Sbjct: 601 MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCV 660
Query: 661 LQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGM 720
LQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGM
Sbjct: 661 LQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGM 720
Query: 721 QLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEA 780
QLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEA
Sbjct: 721 QLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEA 780
Query: 781 NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR 840
NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR
Sbjct: 781 NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR 840
Query: 841 RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL 900
RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL
Sbjct: 841 RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL 900
Query: 901 TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQR 960
TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQR
Sbjct: 901 TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQR 960
Query: 961 VQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLP 1020
VQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLP
Sbjct: 961 VQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLP 1020
Query: 1021 KGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHL 1080
KGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHL
Sbjct: 1021 KGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHL 1080
Query: 1081 ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINL 1140
ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINL
Sbjct: 1081 ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINL 1140
Query: 1141 MELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF 1200
MELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF
Sbjct: 1141 MELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF 1200
Query: 1201 SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM 1260
SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM
Sbjct: 1201 SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM 1260
Query: 1261 DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG 1320
DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG
Sbjct: 1261 DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG 1320
Query: 1321 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNM 1380
QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNM
Sbjct: 1321 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNM 1380
Query: 1381 ISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLS 1440
ISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLS
Sbjct: 1381 ISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLS 1440
Query: 1441 IVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI 1500
IVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI
Sbjct: 1441 IVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI 1500
Query: 1501 GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM 1560
GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM
Sbjct: 1501 GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM 1560
Query: 1561 LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE
Sbjct: 1561 LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
Query: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL
Sbjct: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
Query: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII
Sbjct: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
Query: 1741 QKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD 1791
QKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD
Sbjct: 1741 QKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD 1791
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 1605 bits (4156), Expect = 0.0
Identities = 904/1834 (49%), Positives = 1177/1834 (64%), Gaps = 207/1834 (11%)
Query: 17 RPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQP--RPQLDLKASRKLPKLYGDIPRELI 74
RPFT +SLAAIE+R A+++E + +++ E+ +P +P+ DL+A + LP +YGD P E+I
Sbjct: 18 RPFTRESLAAIEQR-AVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGDPPPEVI 76
Query: 75 GKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMF 134
G PLEDLDP+Y N KTF+VLN+ + I+RFSA AL++ PF+ +R AI+V +H+LFSMF
Sbjct: 77 GIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMF 136
Query: 135 IIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDP 194
I+ T++ NCVFM + N E FTGIY FE+LIKILARGF +D+F+FLRDP
Sbjct: 137 IMITILTNCVFMTMSDPPPWSKN----VEYTFTGIYTFESLIKILARGFCVDDFTFLRDP 192
Query: 195 WNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK-- 252
WNWLD VI +A ++ + + LRTFRV RALK I+V+ LK IVGAL++SVKK
Sbjct: 193 WNWLDFSVIMMAYLTEFVDLG-NISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLS 251
Query: 253 ---LVNVIILTFFC---LSIF--------------------------------ALVGQQL 274
++ V L+ F L +F G ++
Sbjct: 252 DVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEM 311
Query: 275 FMGSLNLKCISRDCKNISNPEAYDHCFEKK------------ENSPEFKMCGIWMGNSAC 322
+ G N + D N A + F+ E S + +CG C
Sbjct: 312 WYG--NDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHC 369
Query: 323 SIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIV 382
YEC T NP+Y YT++D F W+FLA+FRLMTQD WE L+Q TLR G + FF+V
Sbjct: 370 PEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVV 429
Query: 383 VIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDR 442
+IFLGSFYLINL LAVV MAY EQN+ AE + KE+ FQ+ + K+ +E L
Sbjct: 430 IIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL------- 482
Query: 443 SSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK-DQPPGSDSDEDCQKKPQLLEQTKRL 501
+K K+ E G+ D P +DC
Sbjct: 483 ---------------------EKAKAAQALEGGEADGDPAHG--KDC------------- 506
Query: 502 SQNLSLDHFD-EHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCC 560
N SLD E G P Q S +S M+E E++ + C P A K L+WNCC
Sbjct: 507 --NGSLDTSQGEKGAPRQSSSGDSGISD---AMEELEEAHQKCPPWWYKCAHKVLIWNCC 561
Query: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620
WL K ++ ++ DPF +L ITICI++NT+F+AMEH+ M F+ +L +GNLVFT IF
Sbjct: 562 APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621
Query: 621 IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKL 680
AEM LK+IA+DPY YF++GWNIFDSI+ LS ++ +Q S LRSFR+LRVFKL
Sbjct: 622 TAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLS--VLRSFRLLRVFKL 679
Query: 681 AKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ--KSPKLCNP 738
AKSWPTLN LIKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+ K CN
Sbjct: 680 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN- 738
Query: 739 TGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIG 798
L WHM DF+HSFL+VFRILCGEWIE MW+CM+ A ++C+ VF+++ VIG
Sbjct: 739 -------LPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAG--QAMCLTVFLMVMVIG 789
Query: 799 KLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCH-KW 857
LVVLNLF+ALLL+SFS + + E + +Q+A+ R + F + L H K
Sbjct: 790 NLVVLNLFLALLLSSFSADSLAASDE-DGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKI 848
Query: 858 CRKQNL---------PQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLG 908
+++ + AG A + + P ++K+ + +G+ P +L
Sbjct: 849 LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLE 908
Query: 909 VRH-------DWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRV 961
+ H T P+A EE D+E E+ ++PE ++KKP
Sbjct: 909 LDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPE----------DSKKP----- 953
Query: 962 QSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL----QDGFGWLPEMVPKKQPER 1017
P+ D S S CST D +D E +QPE
Sbjct: 954 -------------------PQPLYDGNS--SVCSTADYKPPEEDPEEQAEENPEGEQPEE 992
Query: 1018 CLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFED 1077
C + +PC VD + WW LR+ C++IV+H+WFE+FI+F+ILLSSGAL FED
Sbjct: 993 CFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFED 1052
Query: 1078 VHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTL 1137
+++E + I+ +L D +FT+IFI+EM+LKWVA+GF YFT+AWC LDF+IV VS+ +L
Sbjct: 1053 IYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISL 1112
Query: 1138 I-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWL 1190
+ L +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL
Sbjct: 1113 VANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
Query: 1191 VFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQCES----GNFSWINQKVNFDNVGN 1245
+F I+GV F+GKF CIN T S + + + NKS+CES G W+N KVN+DNVG
Sbjct: 1173 IFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGL 1232
Query: 1246 AYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIG 1305
YL+LLQVATFKGWMDI+YAAVDS EKE+QP++E N Y+YFV+FIIFGSFFTLNLFIG
Sbjct: 1233 GYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIG 1292
Query: 1306 VIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTS 1365
VIIDNFNQQ+KKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V+D+VT
Sbjct: 1293 VIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTK 1352
Query: 1366 QIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYF 1425
Q FDI I+ LI LNM++MM E+ NQ + IL ++N +F++IFT EC++K+ ALRQYYF
Sbjct: 1353 QAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYF 1412
Query: 1426 TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRT 1485
T GWN+FD VVV+LSIV +S L + + PTLFR++RLARIGR+LRL+R A+GIRT
Sbjct: 1413 TVGWNIFDFVVVILSIVGLALSDLIQKYFV--SPTLFRVIRLARIGRVLRLIRGAKGIRT 1470
Query: 1486 LLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLF 1545
LLFALMMSLP+LFNIGLLLFL+MFIY+I GM+ F+ V ESGIDD+FNF+TF +S++CLF
Sbjct: 1471 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLF 1530
Query: 1546 QISTSAGWDSLLSPMLRS-KESCNSSSEN--------CHLPGIATSYFVSYIIISFLIVV 1596
+I+TSAGWD LL+P+L S C+ + EN C P I +F SYIIISFLIVV
Sbjct: 1531 EITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVV 1590
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEP 1656
NMYIA+ILENFN ATEES +PLGEDDF++FYE WEKFDP+ATQFI YS LSDF D L EP
Sbjct: 1591 NMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEP 1650
Query: 1657 LRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANP 1716
LR+AKPNK + + +DLPMV D++HC+DILFA T VLG S +D++K MEEKFM ANP
Sbjct: 1651 LRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANP 1710
Query: 1717 LKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
K YEPI TT KRK EE A IQ+A+R+++++
Sbjct: 1711 SKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQ 1744
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 1375 bits (3559), Expect = 0.0
Identities = 739/1330 (55%), Positives = 927/1330 (69%), Gaps = 74/1330 (5%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941
E ++ T++E G D + P+A E D + ED + E
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 942 PEQQAYELHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKK-----------SD 986
+ E + P S+ V SE E + D R++
Sbjct: 1072 ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGET 1131
Query: 987 VTSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVI 1041
SE ST D+ + L E +P K PE C +G PCC+VD + P +
Sbjct: 1132 PEDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV 1190
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
WW LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F
Sbjct: 1191 WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVF 1250
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRP 1154
+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRP
Sbjct: 1251 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRP 1310
Query: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--D 1212
LRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1311 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD 1370
Query: 1213 SVINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268
+NYTI+ NKSQCES G W KVNFDNVG YLALLQVATFKGWMDI+YAAVD
Sbjct: 1371 LPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1430
Query: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE 1328
S E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEE
Sbjct: 1431 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1490
Query: 1329 QKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESY 1388
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+
Sbjct: 1491 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1550
Query: 1389 NQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMIST 1448
+Q +IL +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S
Sbjct: 1551 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1610
Query: 1449 LENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIM 1508
+ + F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+M
Sbjct: 1611 IIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
Query: 1509 FIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------ 1562
FIY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
Query: 1563 --SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL E
Sbjct: 1729 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1788
Query: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
DDFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+
Sbjct: 1789 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1848
Query: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
HCMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +I
Sbjct: 1849 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1908
Query: 1741 QKAFRKYMMK 1750
Q+AFR+++++
Sbjct: 1909 QRAFRRHLLQ 1918
Score = 453 bits (1165), Expect = e-127
Identities = 256/516 (49%), Positives = 334/516 (64%), Gaps = 37/516 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A + + + LRTFRV RALK ISV+S LK IVGAL++S
Sbjct: 188 FLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRALKTISVISGLKTIVGALIQS 246
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-------------------- 289
VKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 247 VKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDL 306
Query: 290 NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSF 349
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+F
Sbjct: 307 YLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAF 362
Query: 350 LAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKN 409
LA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422
Query: 410 VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKRK 467
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 423 TIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRM 482
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 483 SSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1368
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1369 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1408
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 1409 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1468
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + + ++K + A + L +K
Sbjct: 1469 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1505
Score = 85.9 bits (211), Expect = 3e-16
Identities = 81/343 (23%), Positives = 150/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVSVTT-LINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ TT ++L + + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 82.8 bits (203), Expect = 3e-15
Identities = 155/803 (19%), Positives = 286/803 (35%), Gaps = 173/803 (21%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
++ + IFA+VG QLF KN S D
Sbjct: 843 TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
+ + P ++ +F + +FL +FR++ + E ++ +
Sbjct: 873 --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418
+ F++V+ +G+ ++NL LA++ ++ N E K
Sbjct: 916 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
Query: 419 KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476
+ LL++ + A+ + + T Y P+ K+ +K F E
Sbjct: 976 TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
Query: 477 DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRAL 523
PG SD+D+ + + L + S+ + R
Sbjct: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTW 1095
Query: 524 SAVSILTITMKEQEKSQ---------EPCLP-CGENLASKYLVWNCCPQWLCVKKV---- 569
S VS + E SQ EP P CGE + + +
Sbjct: 1096 SQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIP 1155
Query: 570 -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607
L + DP FTE + C + T + +EH E F
Sbjct: 1156 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMI 1215
Query: 608 MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645
+L+ G L F I++ E M LK +A YF W D
Sbjct: 1216 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLD 1275
Query: 646 SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704
++ +S ++ L ++S R LR + ++ + ++ VGA+ S +
Sbjct: 1276 FLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 1335
Query: 705 TVVLVIVIF--IFSVVGMQLFGRSF------------------NSQKSPKLCNPTGPTVS 744
V+LV +IF IFS++G+ LF F N++ + N TG
Sbjct: 1336 NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1395
Query: 745 CLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS-------LCVIVFILITV 796
+ + +L + ++ + W++ M+ + I F++ +
Sbjct: 1396 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1455
Query: 797 IGKLVVLNLFIALLLNSFSNEER 819
G LNLFI +++++F+ +++
Sbjct: 1456 FGSFFTLNLFIGVIIDNFNQQKK 1478
Score = 62.4 bits (150), Expect = 4e-09
Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 78/339 (23%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677
+KI+A L + + R WN D V +++ F D+ N LR+FRVLR
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSA-------LRTFRVLRA 226
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF-- 727
K L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA 286
Query: 728 -------------------------------NSQKSPKLCNPTGPTVSCLRHWH------ 750
N LC + +C +
Sbjct: 287 LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGE 346
Query: 751 --------MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVV 802
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G +
Sbjct: 347 NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYL 404
Query: 803 LNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+NL +A++ ++ + + E E ++ + Q A++ ++
Sbjct: 405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 52.8 bits (125), Expect = 3e-06
Identities = 39/174 (22%), Positives = 83/174 (47%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ + + L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGN----------VSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1573 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1628 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1664
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1665 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1700
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1761 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1810
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 1375 bits (3559), Expect = 0.0
Identities = 738/1329 (55%), Positives = 931/1329 (70%), Gaps = 73/1329 (5%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA---PLAEEEDDVEFSGEDNAQRITQ 939
E ++ T++E G D + +AE + D + E+N+ +
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 940 PEPEQQAYELHQENKKPTSQRVQS-VEIDMFSEDEPHLTIQDPRKK-----------SDV 987
+Q++ + + P R S V SE E + D R++
Sbjct: 1072 ESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETP 1131
Query: 988 TSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVIW 1042
SE ST D+ + L E +P K PE C +G PCC+VD + P +W
Sbjct: 1132 EDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVW 1190
Query: 1043 WNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFI 1102
W LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F+
Sbjct: 1191 WRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFV 1250
Query: 1103 LEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPL 1155
LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRPL
Sbjct: 1251 LEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPL 1310
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--DS 1213
RALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1311 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDL 1370
Query: 1214 VINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDS 1269
+NYTI+ NKSQCES G W KVNFDNVG YLALLQVATFKGWMDI+YAAVDS
Sbjct: 1371 PLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1430
Query: 1270 TEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQ 1329
E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQ
Sbjct: 1431 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQ 1490
Query: 1330 KKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYN 1389
KKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+ +
Sbjct: 1491 KKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDD 1550
Query: 1390 QPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449
Q +IL +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S +
Sbjct: 1551 QSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDI 1610
Query: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509
+ F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+MF
Sbjct: 1611 IQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1668
Query: 1510 IYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------- 1562
IY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1669 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1728
Query: 1563 -SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGED 1621
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL ED
Sbjct: 1729 PTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1788
Query: 1622 DFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLH 1681
DFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+H
Sbjct: 1789 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIH 1848
Query: 1682 CMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQ 1741
CMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +IQ
Sbjct: 1849 CMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1908
Query: 1742 KAFRKYMMK 1750
+AFR+++++
Sbjct: 1909 RAFRRHLLQ 1917
Score = 453 bits (1165), Expect = e-127
Identities = 256/516 (49%), Positives = 334/516 (64%), Gaps = 37/516 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A + + + LRTFRV RALK ISV+S LK IVGAL++S
Sbjct: 188 FLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRALKTISVISGLKTIVGALIQS 246
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-------------------- 289
VKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 247 VKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDL 306
Query: 290 NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSF 349
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+F
Sbjct: 307 YLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAF 362
Query: 350 LAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKN 409
LA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422
Query: 410 VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKRK 467
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 423 TIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRM 482
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 483 SSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1367
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1368 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1407
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 1408 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1467
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + + ++K + A + L +K
Sbjct: 1468 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1504
Score = 85.9 bits (211), Expect = 3e-16
Identities = 81/343 (23%), Positives = 150/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVSVTT-LINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ TT ++L + + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 62.4 bits (150), Expect = 4e-09
Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 78/339 (23%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677
+KI+A L + + R WN D V +++ F D+ N LR+FRVLR
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSA-------LRTFRVLRA 226
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF-- 727
K L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA 286
Query: 728 -------------------------------NSQKSPKLCNPTGPTVSCLRHWH------ 750
N LC + +C +
Sbjct: 287 LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGE 346
Query: 751 --------MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVV 802
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G +
Sbjct: 347 NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYL 404
Query: 803 LNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+NL +A++ ++ + + E E ++ + Q A++ ++
Sbjct: 405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 61.2 bits (147), Expect = 9e-09
Identities = 40/139 (28%), Positives = 68/139 (48%), Gaps = 6/139 (4%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLF 275
++ + IFA+VG QLF
Sbjct: 843 TLVLAIIVFIFAVVGMQLF 861
Score = 52.8 bits (125), Expect = 3e-06
Identities = 39/174 (22%), Positives = 83/174 (47%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ + + L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGN----------VSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1571
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1572 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1626
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1627 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1663
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1664 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1699
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1700 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1759
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1760 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1809
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 1375 bits (3559), Expect = 0.0
Identities = 739/1330 (55%), Positives = 927/1330 (69%), Gaps = 74/1330 (5%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941
E ++ T++E G D + P+A E D + ED + E
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 942 PEQQAYELHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKK-----------SD 986
+ E + P S+ V SE E + D R++
Sbjct: 1072 ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGET 1131
Query: 987 VTSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVI 1041
SE ST D+ + L E +P K PE C +G PCC+VD + P +
Sbjct: 1132 PEDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV 1190
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
WW LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F
Sbjct: 1191 WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVF 1250
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRP 1154
+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRP
Sbjct: 1251 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRP 1310
Query: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--D 1212
LRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1311 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD 1370
Query: 1213 SVINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268
+NYTI+ NKSQCES G W KVNFDNVG YLALLQVATFKGWMDI+YAAVD
Sbjct: 1371 LPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1430
Query: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE 1328
S E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEE
Sbjct: 1431 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1490
Query: 1329 QKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESY 1388
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+
Sbjct: 1491 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1550
Query: 1389 NQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMIST 1448
+Q +IL +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S
Sbjct: 1551 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1610
Query: 1449 LENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIM 1508
+ + F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+M
Sbjct: 1611 IIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
Query: 1509 FIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------ 1562
FIY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
Query: 1563 --SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL E
Sbjct: 1729 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1788
Query: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
DDFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+
Sbjct: 1789 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1848
Query: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
HCMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +I
Sbjct: 1849 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1908
Query: 1741 QKAFRKYMMK 1750
Q+AFR+++++
Sbjct: 1909 QRAFRRHLLQ 1918
Score = 453 bits (1166), Expect = e-127
Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
FLRDPWNWLD VI +A VS I + L LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289
SVKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
Query: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+
Sbjct: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408
FLA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
Query: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
Query: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1368
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1369 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1408
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 1409 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1468
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + + ++K + A + L +K
Sbjct: 1469 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1505
Score = 83.6 bits (205), Expect = 2e-15
Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ V+ I L L + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 82.8 bits (203), Expect = 3e-15
Identities = 155/803 (19%), Positives = 286/803 (35%), Gaps = 173/803 (21%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
++ + IFA+VG QLF KN S D
Sbjct: 843 TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
+ + P ++ +F + +FL +FR++ + E ++ +
Sbjct: 873 --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418
+ F++V+ +G+ ++NL LA++ ++ N E K
Sbjct: 916 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
Query: 419 KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476
+ LL++ + A+ + + T Y P+ K+ +K F E
Sbjct: 976 TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
Query: 477 DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRAL 523
PG SD+D+ + + L + S+ + R
Sbjct: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTW 1095
Query: 524 SAVSILTITMKEQEKSQ---------EPCLP-CGENLASKYLVWNCCPQWLCVKKV---- 569
S VS + E SQ EP P CGE + + +
Sbjct: 1096 SQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIP 1155
Query: 570 -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607
L + DP FTE + C + T + +EH E F
Sbjct: 1156 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMI 1215
Query: 608 MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645
+L+ G L F I++ E M LK +A YF W D
Sbjct: 1216 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLD 1275
Query: 646 SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704
++ +S ++ L ++S R LR + ++ + ++ VGA+ S +
Sbjct: 1276 FLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 1335
Query: 705 TVVLVIVIF--IFSVVGMQLFGRSF------------------NSQKSPKLCNPTGPTVS 744
V+LV +IF IFS++G+ LF F N++ + N TG
Sbjct: 1336 NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1395
Query: 745 CLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS-------LCVIVFILITV 796
+ + +L + ++ + W++ M+ + I F++ +
Sbjct: 1396 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1455
Query: 797 IGKLVVLNLFIALLLNSFSNEER 819
G LNLFI +++++F+ +++
Sbjct: 1456 FGSFFTLNLFIGVIIDNFNQQKK 1478
Score = 66.2 bits (160), Expect = 3e-10
Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L + + R WN D V ++++ N L S LR+FRVLR K
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727
P L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750
N LC + +C +
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G ++NL
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+A++ ++ + + E E ++ + Q A++ ++
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 55.1 bits (131), Expect = 6e-07
Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ VS I L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1573 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1628 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1664
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1665 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1700
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1761 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1810
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 1369 bits (3544), Expect = 0.0
Identities = 734/1310 (56%), Positives = 923/1310 (70%), Gaps = 88/1310 (6%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941
E ++ T++E G D + P+A E D + Q E
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTD----------DQEE 1061
Query: 942 PEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQD 1001
E+ + +E+ K T + D SE +D+T+ T +L +
Sbjct: 1062 DEENSLGTEEESSKQTPE-------DSCSEGST----------ADMTN------TAELLE 1098
Query: 1002 GFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESF 1061
L + V K PE C +G PCC+VD + P +WW LRKTCY IV+HSWFE+F
Sbjct: 1099 QIPDLGQDV--KDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETF 1156
Query: 1062 IIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSA 1121
IIF+ILLSSGAL FED++LE + I+ LL D +FT++F+LEM+LKWVA+GF KYFT+A
Sbjct: 1157 IIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNA 1216
Query: 1122 WCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGA 1174
WC LDF+IV VS+ +L+ + +KS RTLRALRPLRALS+FEGM+VVVNAL+GA
Sbjct: 1217 WCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1276
Query: 1175 IPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--DSVINYTIITNKSQCES---- 1228
IP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D +NYTI+ NKSQCES
Sbjct: 1277 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLT 1336
Query: 1229 GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYF 1288
G W KVNFDNVG YLALLQVATFKGWMDI+YAAVDS E+QP++E N YIYF
Sbjct: 1337 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1396
Query: 1289 VVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1348
V+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1397 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1456
Query: 1349 PRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVI 1408
PRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+ +Q +IL +N +FV I
Sbjct: 1457 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1516
Query: 1409 FTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLA 1468
FT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S + + F PTLFR++RLA
Sbjct: 1517 FTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLA 1574
Query: 1469 RIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGI 1528
RIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIY+I GM F+ V E+GI
Sbjct: 1575 RIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGI 1634
Query: 1529 DDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIA 1580
DD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L + + N S +C P +
Sbjct: 1635 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVG 1694
Query: 1581 TSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQF 1640
+F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL EDDFD+FYE+WEKFDPEATQF
Sbjct: 1695 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1754
Query: 1641 IKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGL 1700
I+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+HCMDILFAFT RVLG S +
Sbjct: 1755 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1814
Query: 1701 DSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
D++K MEEKFM ANP K YEPI TT +RK EE A +IQ+AFR+++++
Sbjct: 1815 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQ 1864
Score = 453 bits (1166), Expect = e-127
Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
FLRDPWNWLD VI +A VS I + L LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289
SVKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
Query: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+
Sbjct: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408
FLA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
Query: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
Query: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 105 bits (263), Expect = 3e-22
Identities = 148/756 (19%), Positives = 287/756 (37%), Gaps = 133/756 (17%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
++ + IFA+VG QLF KN S D
Sbjct: 843 TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
+ + P ++ +F + +FL +FR++ + E ++ +
Sbjct: 873 --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418
+ F++V+ +G+ ++NL LA++ ++ N E K
Sbjct: 916 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
Query: 419 KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476
+ LL++ + A+ + + T Y P+ K+ +K F E
Sbjct: 976 TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
Query: 477 DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDE--HGDPLQRQR 521
PG SD+D+ + + L + S+ D E D
Sbjct: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTADMTNTAE 1095
Query: 522 ALSAVSILTITMKEQEK-------SQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVM 574
L + L +K+ E + PC A + W ++K ++
Sbjct: 1096 LLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWR-------LRKTCYHIV 1148
Query: 575 TDPFTELAITICIIINTVFLAMEHHKME--ASFEKMLNIGNLVFTSIFIAEMCLKIIALD 632
+ E I I++++ LA E +E + + +L + +FT +F+ EM LK +A
Sbjct: 1149 EHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYG 1208
Query: 633 PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIK 692
YF W D ++ +S ++ L ++S R LR + ++ +
Sbjct: 1209 FKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRV 1268
Query: 693 IIGNSVGALGS-LTVVLVIVIF--IFSVVGMQLFGRSF------------------NSQK 731
++ VGA+ S + V+LV +IF IFS++G+ LF F N++
Sbjct: 1269 VVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKS 1328
Query: 732 SPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS----- 785
+ N TG + + +L + ++ + W++ M+ +
Sbjct: 1329 QCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEY 1388
Query: 786 --LCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
I F++ + G LNLFI +++++F+ +++
Sbjct: 1389 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1424
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1314
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1315 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1354
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 1355 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1414
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + + ++K + A + L +K
Sbjct: 1415 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1451
Score = 83.6 bits (205), Expect = 2e-15
Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ V+ I L L + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 66.2 bits (160), Expect = 3e-10
Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L + + R WN D V ++++ N L S LR+FRVLR K
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727
P L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750
N LC + +C +
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G ++NL
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+A++ ++ + + E E ++ + Q A++ ++
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 55.1 bits (131), Expect = 6e-07
Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ VS I L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1459 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1518
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1519 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1573
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1574 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1610
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1611 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1646
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1647 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1706
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1707 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1756
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 1333 bits (3451), Expect = 0.0
Identities = 724/1330 (54%), Positives = 911/1330 (68%), Gaps = 92/1330 (6%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941
E ++ T++E G D + P+A E D + ED + E
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 942 PEQQAYELHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKK-----------SD 986
+ E + P S+ V SE E + D R++
Sbjct: 1072 ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGET 1131
Query: 987 VTSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVI 1041
SE ST D+ + L E +P K PE C +G PCC+VD + P +
Sbjct: 1132 PEDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV 1190
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
WW LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F
Sbjct: 1191 WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVF 1250
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRP 1154
+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRP
Sbjct: 1251 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRP 1310
Query: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--D 1212
LRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1311 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD 1370
Query: 1213 SVINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268
+NYTI+ NKSQCES G W KVNFDNVG YLALLQV
Sbjct: 1371 LPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVY-------------- 1416
Query: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE 1328
E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEE
Sbjct: 1417 ----EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1472
Query: 1329 QKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESY 1388
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+
Sbjct: 1473 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1532
Query: 1389 NQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMIST 1448
+Q +IL +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S
Sbjct: 1533 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1592
Query: 1449 LENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIM 1508
+ + F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+M
Sbjct: 1593 IIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1650
Query: 1509 FIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------ 1562
FIY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1651 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1710
Query: 1563 --SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL E
Sbjct: 1711 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1770
Query: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680
DDFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+
Sbjct: 1771 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1830
Query: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740
HCMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +I
Sbjct: 1831 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1890
Query: 1741 QKAFRKYMMK 1750
Q+AFR+++++
Sbjct: 1891 QRAFRRHLLQ 1900
Score = 453 bits (1166), Expect = e-127
Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
FLRDPWNWLD VI +A VS I + L LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289
SVKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
Query: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+
Sbjct: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408
FLA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
Query: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
Query: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 97.8 bits (242), Expect = 8e-20
Identities = 78/328 (23%), Positives = 150/328 (45%), Gaps = 47/328 (14%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1368
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1369 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1408
Query: 349 FLAMFRLM-TQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
+LA+ ++ Q WE LY +F++ I GSF+ +NL + V+ + +Q
Sbjct: 1409 YLALLQVYEEQPQWE---------YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1459
Query: 408 KNVAAE---IEAKEKMFQEAQQLLKEEK 432
K + + + ++K + A + L +K
Sbjct: 1460 KKLGGQDIFMTEEQKKYYNAMKKLGSKK 1487
Score = 84.0 bits (206), Expect = 1e-15
Identities = 158/785 (20%), Positives = 286/785 (36%), Gaps = 155/785 (19%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
++ + IFA+VG QLF KN S D
Sbjct: 843 TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
+ + P ++ +F + +FL +FR++ + E ++ +
Sbjct: 873 --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418
+ F++V+ +G+ ++NL LA++ ++ N E K
Sbjct: 916 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
Query: 419 KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476
+ LL++ + A+ + + T Y P+ K+ +K F E
Sbjct: 976 TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
Query: 477 DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRAL 523
PG SD+D+ + + L + S+ + R
Sbjct: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTW 1095
Query: 524 SAVSILTITMKEQEKSQ---------EPCLP-CGENLASKYLVWNCCPQWLCVKKV---- 569
S VS + E SQ EP P CGE + + +
Sbjct: 1096 SQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIP 1155
Query: 570 -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607
L + DP FTE + C + T + +EH E F
Sbjct: 1156 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMI 1215
Query: 608 MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645
+L+ G L F I++ E M LK +A YF W D
Sbjct: 1216 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLD 1275
Query: 646 SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704
++ +S ++ L ++S R LR + ++ + ++ VGA+ S +
Sbjct: 1276 FLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 1335
Query: 705 TVVLVIVIF--IFSVVGMQL----FGRSFNSQKSPKLCNPT--GPTVSCLRHWHMGD-FW 755
V+LV +IF IFS++G+ L FGR N + N T C G+ +W
Sbjct: 1336 NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1395
Query: 756 HSFLVVFRILCGEWIENMWECMQEANASSSLCV-IVFILITVIGKLVVLNLFIALLLNSF 814
V F + ++ + ++ +L + I F++ + G LNLFI +++++F
Sbjct: 1396 TKVKVNFDNVGAGYLALLQVYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1455
Query: 815 SNEER 819
+ +++
Sbjct: 1456 NQQKK 1460
Score = 83.6 bits (205), Expect = 2e-15
Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ V+ I L L + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 66.2 bits (160), Expect = 3e-10
Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L + + R WN D V ++++ N L S LR+FRVLR K
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727
P L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750
N LC + +C +
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G ++NL
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+A++ ++ + + E E ++ + Q A++ ++
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 55.1 bits (131), Expect = 6e-07
Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ VS I L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1495 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1554
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1555 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1609
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1610 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1646
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1647 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1682
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1683 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1742
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1743 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1792
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 1332 bits (3447), Expect = 0.0
Identities = 711/1289 (55%), Positives = 904/1289 (70%), Gaps = 61/1289 (4%)
Query: 505 LSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWL 564
LS ++ DE P + QRA+S VSI+T ++E E+S++ C PC +L+ KYL+W+CCP W+
Sbjct: 596 LSAEYLDE---PFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWV 652
Query: 565 CVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEM 624
+K +L ++TDPF EL IT+CI++NT+F+AMEHH M +FE ML IGN+VFT F AEM
Sbjct: 653 KLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEM 712
Query: 625 CLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684
KIIA DPY+YF++ WNIFD I+ +S ++ V +K S LRSFR+LRVFKLAKSW
Sbjct: 713 VFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELG--VAKKGSLSVLRSFRLLRVFKLAKSW 770
Query: 685 PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVS 744
PTLNTLIKIIGNSVGALG+LT++L I++F+F++VG QL G ++ + + N + P
Sbjct: 771 PTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRK----NISAPHED 826
Query: 745 CLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLN 804
R WHM DF+HSFL+VFRILCGEWIENMW CM+ S+C+I+F+ + V+G LVVLN
Sbjct: 827 WPR-WHMHDFFHSFLIVFRILCGEWIENMWACMEVGQ--KSICLILFLTVMVLGNLVVLN 883
Query: 805 LFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLP 864
LFIALLLNSFS + E + +Q+AL R + F T + C + R P
Sbjct: 884 LFIALLLNSFSADNLTAP-EDDGEVNNLQVALARIQ---VFGHRTKQALCSFFSRSCPFP 939
Query: 865 QQKE----VAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PL 919
Q K V + SK + RGS + + + + W++ P+
Sbjct: 940 QPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPI 999
Query: 920 AEEE---DDVEFSGEDNAQRITQPE-PEQQAYELHQENKKPTSQRVQSVEIDMFSED--- 972
AE E DD+E G ++AQ Q P+ Q +L Q + +S SED
Sbjct: 1000 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAP 1059
Query: 973 ------EPHLTIQDPRKKSDVTSILSECSTIDLQDG---FGWLPEMVPK-KQPERCLPKG 1022
+ Q P + D TS SE ST+D D +PE+ ++P+ C +G
Sbjct: 1060 SLGETWKDESVPQVPAEGVDDTSS-SEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEG 1118
Query: 1023 FGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLEN 1082
PCC +D K PW + W +RKTCY+IV+HSWFESFIIF+ILLSSG+L FED +L+
Sbjct: 1119 CIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQ 1178
Query: 1083 QPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI---- 1138
+P ++ LL TD +FT IF+ EM+LKWVA+GF KYFT+AWC LDF+IV +S+ +L
Sbjct: 1179 KPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKIL 1238
Query: 1139 ---NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCIL 1195
+ +K+ RTLRALRPLRALS+FEGM+VVV+AL+GAIP+I+NVLLVCLIFWL+F I+
Sbjct: 1239 EYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIM 1298
Query: 1196 GVYFFSGKFGKCINGTD---SVINYTIITNKSQCE----SGNFSWINQKVNFDNVGNAYL 1248
GV F+GKF +CIN TD S++ +I+ NKS C+ +G+F W+N KVNFDNV YL
Sbjct: 1299 GVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYL 1358
Query: 1249 ALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVII 1308
ALLQVATFKGWMDI+YAAVDS E QP++E N Y+YFV+FIIFG FFTLNLF+GVII
Sbjct: 1359 ALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVII 1418
Query: 1309 DNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIF 1368
DNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG VFDIVT Q F
Sbjct: 1419 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAF 1478
Query: 1369 DIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNG 1428
DI I+ LI LNMI+MM E+ +Q + IL +N FV +FT EC++K+FALRQYYFTNG
Sbjct: 1479 DITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNG 1538
Query: 1429 WNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLF 1488
WN+FD +VV+LSI S + S + F PTLFR++RLARIGRILRL+RAA+GIRTLLF
Sbjct: 1539 WNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLF 1598
Query: 1489 ALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQIS 1548
ALMMSLP+LFNIGLLLFL+MFIY+I GM+ F V E+GIDD+FNF+TFA+SMLCLFQI+
Sbjct: 1599 ALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQIT 1658
Query: 1549 TSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYI 1600
TSAGWD LLSP+L + + N + +C P + +F +YIIISFLI+VNMYI
Sbjct: 1659 TSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYI 1718
Query: 1601 AVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVA 1660
AVILENFN ATEES +PL EDDFD+FYE WEKFDPEATQFI +SALSDFAD L PLR+
Sbjct: 1719 AVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIP 1778
Query: 1661 KPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKL 1720
KPN+ + MDLP+V D++HC+DILFAFT VLG S LDS+KA MEEKFM N K
Sbjct: 1779 KPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSS 1838
Query: 1721 YEPIVTTTKRKEEERGAAIIQKAFRKYMM 1749
YEPI TT + K+E+ A +IQKA+R Y++
Sbjct: 1839 YEPIATTLRWKQEDISATVIQKAYRSYVL 1867
Score = 471 bits (1213), Expect = e-132
Identities = 265/519 (51%), Positives = 342/519 (65%), Gaps = 20/519 (3%)
Query: 6 YPVIFPDERNFRPFTSDSLAAIEKRIAIQ----KEKKKSKDQTGEVPQPRPQLDLKASRK 61
+P+ + NFR FT +SL IEK+IA + K ++K ++Q + +PRPQLDLKA +
Sbjct: 3 FPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQ 62
Query: 62 LPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSL 121
LPK YG++P ELIG+PLEDLDPFY H+TFMVLN+ RTI RFSA AL++F PFN IR
Sbjct: 63 LPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRT 122
Query: 122 AIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILAR 181
AI+VSVHS FS+FI T+++NCV M + ++ + E VFT IY FEALIKILAR
Sbjct: 123 AIKVSVHSWFSLFITVTILVNCVCM-------TRTDLPEKIEYVFTVIYTFEALIKILAR 175
Query: 182 GFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK-LLPLRTFRVFRALKAISVVSRLK 240
GF L+EF++LRDPWNWLD VI +A V I ++ + LRTFRV RALK +SV+ LK
Sbjct: 176 GFCLNEFTYLRDPWNWLDFSVITLAYVG--TAIDLRGISGLRTFRVLRALKTVSVIPGLK 233
Query: 241 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-----NISNPE 295
VIVGAL+ SVKKL +V ILT FCLS+FALVG QLF G+L KC+ D N S+
Sbjct: 234 VIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHR 293
Query: 296 AYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRL 355
D K+ S +CG + C Y C T NPD+NYT+FD+F W+FL++FRL
Sbjct: 294 KPDIYINKRGTSDPL-LCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRL 352
Query: 356 MTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE 415
MTQDSWE+LYQQTLRT+G + FF++VIFLGSFYL+NL LAVVTMAYEEQN+ EIE
Sbjct: 353 MTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIE 412
Query: 416 AKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESG 475
AKEK FQEA ++L++E+E L A+GID +SL S S T K ++ + +
Sbjct: 413 AKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTE 472
Query: 476 KDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHG 514
++ P SD + L KR + + S+ HF G
Sbjct: 473 DNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPG 511
Score = 99.8 bits (247), Expect = 2e-20
Identities = 89/332 (26%), Positives = 150/332 (45%), Gaps = 62/332 (18%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+T ++ HSWF FI IL++ + D+ KI+ +FT I+ E
Sbjct: 119 IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDL----PEKIE-------YVFTVIYTFE 167
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF Y W LDF +I + V T I+L + RT R LR L+ +S
Sbjct: 168 ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVS 227
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCINGTDSVINYT 1218
G+KV+V ALI ++ + +V ++ + VF ++G+ F G KC+ D +N T
Sbjct: 228 VIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKN-DMAVNET 286
Query: 1219 ----------IITNKSQ------CESGNFS------WINQKVN---------FDNVGNAY 1247
I NK C +G+ S +I K + FD+ A+
Sbjct: 287 TNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAF 346
Query: 1248 LALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
L+L ++ T W + QQ S + I+FV+ I GSF+ +NL + V+
Sbjct: 347 LSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVV 396
Query: 1308 IDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
+ +Q + + + ++KK+ A++ L
Sbjct: 397 TMAYEEQNQATTDE---IEAKEKKFQEALEML 425
Score = 99.0 bits (245), Expect = 4e-20
Identities = 80/345 (23%), Positives = 154/345 (44%), Gaps = 62/345 (17%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGP----AKNSNSNNTDIAECVFTGIYIFE 173
+R R+ HS F FII ++++ +A K + + + VFT I++FE
Sbjct: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP---------LRTF 224
L+K +A GF + + W WLD +++ I+++S +T K+L LRT
Sbjct: 1201 MLLKWVAYGFK----KYFTNAWCWLDFLIVNISLIS----LTAKILEYSEVAPIKALRTL 1252
Query: 225 RVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCI 284
R R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI
Sbjct: 1253 RALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-WRCI 1311
Query: 285 SRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY----T 340
+ EF + + + N+ + +CK + +
Sbjct: 1312 N-------------------YTDGEFSLVPLSIVNN----KSDCKIQNSTGSFFWVNVKV 1348
Query: 341 NFDNFGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFY 390
NFDN +LA+ ++ T W ++ Q +Y +F++ I G F+
Sbjct: 1349 NFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFF 1408
Query: 391 LINLTLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+NL + V+ + +Q K + + + ++K + A + L +K
Sbjct: 1409 TLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1453
Score = 83.6 bits (205), Expect = 2e-15
Identities = 157/804 (19%), Positives = 296/804 (36%), Gaps = 175/804 (21%)
Query: 139 VIINCVFMATGPAKNSNSNNT--DIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA S + I VFT + E + KI+A D + + + WN
Sbjct: 675 IVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQKKWN 730
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
D I++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 731 IFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 790
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
I+ + +FALVG+QL + + KNIS P E+ P + M
Sbjct: 791 TIILAIIVFVFALVGKQLLGENYR-----NNRKNISAPH---------EDWPRWHM---- 832
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
+F SFL +FR++ + E ++
Sbjct: 833 --------------------------HDFFHSFLIVFRILCGEWIENMWACMEVGQKSIC 866
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQN----------KNVAAEIEAKEKMFQEAQQ 426
+ F+ V+ LG+ ++NL +A++ ++ N N+ + + +Q
Sbjct: 867 LILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQ 926
Query: 427 LL-------------KEEKEALVAMGIDRSSL-------TSLETSYFTPKKRKLFGNKKR 466
L K E E +V + + S T+ +S R G +
Sbjct: 927 ALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPR---GPRDE 983
Query: 467 KSFFLR-------------ESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEH 513
S F+ ES D D ED Q Q + + Q ++ +H
Sbjct: 984 HSDFIANPTVWVSVPIAEGESDLDDLE-DDGGEDAQSFQQEVIPKGQQEQLQQVERCGDH 1042
Query: 514 GDPLQRQRALSAVSI---LTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKV- 569
P S+ + L T K++ Q P + +S+ +C ++K+
Sbjct: 1043 LTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIP 1102
Query: 570 -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607
L + +P FTE I C + T + +EH E+ F
Sbjct: 1103 ELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMI 1162
Query: 608 MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645
+L+ G+L F ++ + M LK +A YF W D
Sbjct: 1163 LLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLD 1222
Query: 646 SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704
++ +S + +L+ +++ R LR + ++ + ++ VGA+ S +
Sbjct: 1223 FLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIM 1282
Query: 705 TVVLVIVIF--IFSVVGMQLFGRSF-------------------NSQKSPKLCNPTGPTV 743
V+LV +IF IFS++G+ LF F N++ K+ N TG
Sbjct: 1283 NVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFF 1342
Query: 744 SCLRHWHMGDFWHSFLVVFRILCGE-WIENMWEC-------MQEANASSSLCVIVFILIT 795
+ + +L + ++ + W++ M+ MQ + + F++
Sbjct: 1343 WVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFI 1402
Query: 796 VIGKLVVLNLFIALLLNSFSNEER 819
+ G LNLF+ +++++F+ +++
Sbjct: 1403 IFGGFFTLNLFVGVIIDNFNQQKK 1426
Score = 82.8 bits (203), Expect = 3e-15
Identities = 71/323 (21%), Positives = 135/323 (41%), Gaps = 61/323 (18%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ V + L IT+ I++N V + + + VFT I+ E
Sbjct: 119 IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEY---------VFTVIYTFEAL 169
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L+ + Y R WN D V L++ + + R LR+FRVLR K
Sbjct: 170 IKILARGFCLNEFTYLRDPWNWLDFSVITLAY---VGTAIDLRGISGLRTFRVLRALKTV 226
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ----------- 730
P L ++ + +SV L +T++ + + +F++VG+QLF + ++
Sbjct: 227 SVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNET 286
Query: 731 ------------------KSPKLCNPTGPTVSC--------------LRHWHMGDFWHSF 758
P LC + C + F +F
Sbjct: 287 TNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAF 346
Query: 759 LVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEE 818
L +FR++ + E +++ Q S + +I F+L+ +G ++NL +A++ ++ +
Sbjct: 347 LSLFRLMTQDSWERLYQ--QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQN 404
Query: 819 RNGNLEGEARKTKVQLALDRFRR 841
+ E EA++ K Q AL+ R+
Sbjct: 405 QATTDEIEAKEKKFQEALEMLRK 427
Score = 56.6 bits (135), Expect = 2e-07
Identities = 53/238 (22%), Positives = 99/238 (41%), Gaps = 43/238 (18%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P N + + F + I I++N + M + + + +VF VI+T
Sbjct: 115 PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCM---------TRTDLPEKIEYVFTVIYT 165
Query: 1411 LECLIKI----FALRQY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E LIKI F L ++ Y + WN D V+ L+ V T I +
Sbjct: 166 FEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG-----------ISGL 214
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSK---- 1521
R R+ R L+ V G++ ++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 215 RTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKN 274
Query: 1522 --VNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLP 1577
V + +++ N+ + + + + TS D LL C + S++ H P
Sbjct: 275 KCVKNDMAVNETTNYSSHRKPDIYINKRGTS---DPLL---------CGNGSDSGHCP 320
Score = 48.9 bits (115), Expect = 4e-05
Identities = 38/174 (21%), Positives = 73/174 (41%), Gaps = 17/174 (9%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N + M S + + F ++
Sbjct: 1461 PLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFT 1520
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP----------L 221
E ++K+ F L ++ F WN D IV+ ++I S I +K L +
Sbjct: 1521 GECVMKM----FALRQYYFTNG-WNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVI 1575
Query: 222 RTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
R R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+++ G F
Sbjct: 1576 RLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSF 1629
Score = 32.3 bits (72), Expect = 4.2
Identities = 20/86 (23%), Positives = 37/86 (43%), Gaps = 12/86 (13%)
Query: 1533 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISF 1592
+F +FA + L LF++ T W+ L LR+ I +FV I +
Sbjct: 338 SFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK------------IYMIFFVLVIFLGS 385
Query: 1593 LIVVNMYIAVILENFNTATEESEDPL 1618
+VN+ +AV+ + + + D +
Sbjct: 386 FYLVNLILAVVTMAYEEQNQATTDEI 411
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 1314 bits (3400), Expect = 0.0
Identities = 719/1329 (54%), Positives = 903/1329 (67%), Gaps = 105/1329 (7%)
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527
S LR + PP + + + PQ+L SQ +D F+E G RQRALSAVS
Sbjct: 616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
Query: 528 ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587
+LT ++E E+S+ C PC LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 668 VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 588 IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647
++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM KIIALDPY+YF++GWNIFDSI
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 648 VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
+ +LS ++ + S LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 788 IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
Query: 708 LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767
L I++FIF+VVGMQLFG++++ + L WHM DF+H+FL++FRILCG
Sbjct: 846 LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
Query: 768 EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827
EWIE MW+CM+ + SLC++VF+L+ VIG LVVLNLF+ALLL+SFS + E +
Sbjct: 898 EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
Query: 828 RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882
+QLAL R +R FV+ T FC R++ QK A Q I P
Sbjct: 955 EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
Query: 883 LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA---PLAEEEDDVEFSGEDNAQRITQ 939
E ++ T++E G D + +AE + D + E+N+ +
Sbjct: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 940 PEPEQQAYELHQENKKPTSQRVQS-VEIDMFSEDEPHLTIQDPRKK-----------SDV 987
+Q++ + + P R S V SE E + D R++
Sbjct: 1072 ESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETP 1131
Query: 988 TSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVIW 1042
SE ST D+ + L E +P K PE C +G PCC+VD + P +W
Sbjct: 1132 EDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVW 1190
Query: 1043 WNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFI 1102
W LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE + I+ LL D +FT++F+
Sbjct: 1191 WRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFV 1250
Query: 1103 LEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPL 1155
LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+ + +KS RTLRALRPL
Sbjct: 1251 LEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPL 1310
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--DS 1213
RALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GKFG+CIN T D
Sbjct: 1311 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDL 1370
Query: 1214 VINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDS 1269
+NYTI+ NKSQCES G W KVNFDNVG YLALLQVATFKGWMDI+YAAVDS
Sbjct: 1371 PLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1430
Query: 1270 TEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQ 1329
E+QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQ
Sbjct: 1431 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQ 1490
Query: 1330 KKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYN 1389
KKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+ +
Sbjct: 1491 KKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDD 1550
Query: 1390 QPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449
Q +IL +N +FV IFT L I Q YF
Sbjct: 1551 QSPEKINILAKINLLFVAIFTGTVLSDII---QKYF------------------------ 1583
Query: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509
F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+MF
Sbjct: 1584 -------FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1636
Query: 1510 IYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------- 1562
IY+I GM F+ V E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L
Sbjct: 1637 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1696
Query: 1563 -SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGED 1621
+ + N S +C P + +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL ED
Sbjct: 1697 PTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1756
Query: 1622 DFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLH 1681
DFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+ + MDLPMVS DR+H
Sbjct: 1757 DFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIH 1816
Query: 1682 CMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQ 1741
CMDILFAFT RVLG S +D++K MEEKFM ANP K YEPI TT +RK EE A +IQ
Sbjct: 1817 CMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1876
Query: 1742 KAFRKYMMK 1750
+AFR+++++
Sbjct: 1877 RAFRRHLLQ 1885
Score = 453 bits (1166), Expect = e-127
Identities = 259/517 (50%), Positives = 335/517 (64%), Gaps = 39/517 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITI-KLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
FLRDPWNWLD VI +A VS I + L LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 188 FLRDPWNWLDFSVIIMAYVS--ENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQ 245
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK------------------- 289
SVKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLD 305
Query: 290 -NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+
Sbjct: 306 LYLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWA 361
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNK 408
FLA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 362 FLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ 421
Query: 409 NVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKR 466
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 422 ATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKR 481
Query: 467 KSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 482 MSSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 100 bits (249), Expect = 1e-20
Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173
+R + HS F FII ++++ +A + A+ +FT +++ E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K +A GF + + W WLD +++ +++VS + + LRT R R
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +CI++
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1367
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
++ P Y K + C + ++ E TK+ NFDN G
Sbjct: 1368 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1407
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W + + + G LY +F++ I GSF+ +NL + V
Sbjct: 1408 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1467
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + + ++K + A + L +K
Sbjct: 1468 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1504
Score = 83.6 bits (205), Expect = 2e-15
Identities = 82/343 (23%), Positives = 149/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ V+ I L L + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 66.2 bits (160), Expect = 3e-10
Identities = 67/335 (20%), Positives = 134/335 (40%), Gaps = 70/335 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L + + R WN D V ++++ N L S LR+FRVLR K
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSE-NIKLGNLS--ALRTFRVLRALKTI 230
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF------ 727
P L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 728 ---------------------------NSQKSPKLCNPTGPTVSCLRHWH---------- 750
N LC + +C +
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 751 ----MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLF 806
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G ++NL
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
Query: 807 IALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+A++ ++ + + E E ++ + Q A++ ++
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 61.2 bits (147), Expect = 9e-09
Identities = 40/139 (28%), Positives = 68/139 (48%), Gaps = 6/139 (4%)
Query: 139 VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA ++ + VFTGI+ E KI+A LD + + + WN
Sbjct: 727 IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
DSI++ ++++ L LR+FR+ R K L ++ + SV L N+
Sbjct: 783 IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
Query: 257 IILTFFCLSIFALVGQQLF 275
++ + IFA+VG QLF
Sbjct: 843 TLVLAIIVFIFAVVGMQLF 861
Score = 55.1 bits (131), Expect = 6e-07
Identities = 42/174 (24%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ VS I L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-LGN----------LSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/118 (22%), Positives = 46/118 (38%), Gaps = 29/118 (24%)
Query: 341 NFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFF 380
NF F S L +F++ T W+ L L T Y + FF
Sbjct: 1660 NFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFF 1719
Query: 381 IVVIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
I + ++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1720 TTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1777
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 1302 bits (3370), Expect = 0.0
Identities = 704/1334 (52%), Positives = 929/1334 (69%), Gaps = 98/1334 (7%)
Query: 471 LRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILT 530
L +G+ P G+ ++ + +K+ + S ++S+D + DP RQRA+S SILT
Sbjct: 663 LTSAGQLLPEGTTTETEIRKR-------RSSSYHVSMDLLE---DPTSRQRAMSIASILT 712
Query: 531 ITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIIN 590
TM+E E+S++ C PC A+ L+W+CC WL VK ++ V+ DPF +LAITICI++N
Sbjct: 713 NTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLN 772
Query: 591 TVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL 650
T+F+AMEH+ M F +L++GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD +
Sbjct: 773 TLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVS 832
Query: 651 LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVI 710
LS ++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I
Sbjct: 833 LSLMELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
Query: 711 VIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI 770
++FIF+VVGMQLFG+S+ K+ N L WHM DF+HSFL+VFR+LCGEWI
Sbjct: 891 IVFIFAVVGMQLFGKSYKECVC-KISNDCE-----LPRWHMHDFFHSFLIVFRVLCGEWI 944
Query: 771 ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKT 830
E MW+CM+ A ++C+ VF+++ VIG LVVLNLF+ALLL+SFS++ + +
Sbjct: 945 ETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMN 1001
Query: 831 KVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQN-------LPQQKEVAGGCAAQSK--DI 880
+Q+A+ R ++ FV+ + F K + RKQ L C + +I
Sbjct: 1002 NLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEI 1061
Query: 881 IPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 940
+ +K G+ T +G +SV K + +E D + F + +T P
Sbjct: 1062 GKDLNYLKDGNGTTSGIG--SSVEKYV------------VDESDYMSFINNPSLT-VTVP 1106
Query: 941 EPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL- 999
++ +++ + FS + +++ ++K + TS SE ST+D+
Sbjct: 1107 IAVGES-------------DFENLNTEEFSSESD---MEESKEKLNATSS-SEGSTVDIG 1149
Query: 1000 QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSW 1057
G PE+ P++ +PE C + F CC + + +WWNLRKTCY+IV+H+W
Sbjct: 1150 APAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNW 1209
Query: 1058 FESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKY 1117
FE+FI+F+ILLSSGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF Y
Sbjct: 1210 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY 1269
Query: 1118 FTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNA 1170
FT+AWC LDF+IV VS+ +L L +KS RTLRALRPLRALS+FEGM+VVVNA
Sbjct: 1270 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1329
Query: 1171 LIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES- 1228
L+GAIP+I+NVLLVCLIFWL+F I+GV F+GKF CIN T + + +++ N S+C++
Sbjct: 1330 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL 1389
Query: 1229 ----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLG 1284
W N KVNFDNVG YL+LLQVATFKGWMDI+YAAVDS E QP++E N
Sbjct: 1390 IESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYM 1449
Query: 1285 YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1344
Y+YFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1450 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1509
Query: 1345 QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1404
QKPIPRP NK QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + M +IL +N V
Sbjct: 1510 QKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
F+V+FT EC++K+ +LR YYFT GWN+FD VVV+LSIV ++ L + + PTLFR+
Sbjct: 1570 FIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRV 1627
Query: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
+RLARIGRILRL++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V
Sbjct: 1628 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Query: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS--------KESCNSSSE-NCH 1575
E GIDD+FNF+TF +SM+CLFQI+TSAGWD LL+P+L S K+ SS + +C
Sbjct: 1688 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCG 1747
Query: 1576 LPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDP 1635
P + +FVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP
Sbjct: 1748 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 1807
Query: 1636 EATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLG 1695
+ATQFI+++ LSDFADAL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG
Sbjct: 1808 DATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1867
Query: 1696 GSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK----- 1750
S +D+++ MEE+FM +NP K YEPI TT KRK+EE A IIQ+A+R+Y++K
Sbjct: 1868 ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKK 1927
Query: 1751 ---VTKGDQGDQND 1761
+ K D+G + D
Sbjct: 1928 VSSIYKKDKGKECD 1941
Score = 407 bits (1045), Expect = e-113
Identities = 243/532 (45%), Positives = 317/532 (59%), Gaps = 56/532 (10%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQ--PRPQLDLKASRKLPKLYGD 68
P +FR FT +SLAAIE+RIA +K K+ +++ E + P+P DL+A + LP +YGD
Sbjct: 9 PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGD 68
Query: 69 IPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVH 128
IP E++ PLEDLDP+Y N KTF+VLN+ + I RFSA AL+I PFN IR LAI++ VH
Sbjct: 69 IPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVH 128
Query: 129 SLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
SLF+M I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F
Sbjct: 129 SLFNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDF 184
Query: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
+FLRDPWNWLD VI A V+ + + LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVNLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS---------------- 292
SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 293 --------NPEAYDHCFEKK------ENSPEFKMCGIWMGNSACSIQYECKHTKINPDYN 338
+ +D E K E + +CG C Y C NP+Y
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
YT+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYLINL LAV
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 399 VTMAYEEQNKNVAAEIEAKEKMFQE-AQQLLKEEKEALVAM--------------GIDRS 443
V MAYEEQN+ E E KE FQ+ +QL K+++EA A GI
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
Query: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK----DQPPGSDSDEDCQKK 491
S +S S + K K N+++K +SG+ D+ S+S++ ++K
Sbjct: 484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRK 535
Score = 115 bits (287), Expect = 5e-25
Identities = 158/799 (19%), Positives = 308/799 (38%), Gaps = 154/799 (19%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSNNTDIAECVFTGIYI 171
P+ ++ L V + + I +++N +FMA P S+ + VFTGI+
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALK 231
E +KI+A +D + + ++ WN D ++ ++++ L LR+FR+ R K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 291
L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF---------------- 903
Query: 292 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351
++Y C C I +C+ + + +F SFL
Sbjct: 904 --GKSYKEC--------------------VCKISNDCELPR-------WHMHDFFHSFLI 934
Query: 352 MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN---- 407
+FR++ + E ++ + F++V+ +G+ ++NL LA++ ++ N
Sbjct: 935 VFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 994
Query: 408 --KNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKK 465
N ++ Q+ +K + + R E K + NKK
Sbjct: 995 DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI-----KPLEDLNNKK 1049
Query: 466 R---KSFFLRESGKD-----QPPGSDSDEDCQKKPQLLEQTKRLS--------------- 502
+ E GKD G+ S + +++++ +S
Sbjct: 1050 DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAV 1109
Query: 503 -----QNLSLDHFDEHGDPLQRQRALSAVSI---LTITM----------KEQEKSQEPCL 544
+NL+ + F D + + L+A S T+ + E E+S EP
Sbjct: 1110 GESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEA 1169
Query: 545 PCGENLASKYLVWNCC---------PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLA 595
E+ K+ CC W ++K ++ + E I I++++ LA
Sbjct: 1170 CFTEDCVRKF---KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 596 ME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
E + + + + ML + VFT IFI EM LK +A YF W D ++ +S
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSL 1286
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVI 712
+ L ++S R LR + ++ + ++ +GA+ S + V+LV +I
Sbjct: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
Query: 713 F--IFSVVGMQLFGRSF-----------------NSQKSPKLCNPTGPTVSCLRHW---- 749
F IFS++G+ LF F N+ K + T W
Sbjct: 1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTA----RWKNVK 1402
Query: 750 -HMGDFWHSFLVVFRILCGE-WIENMWECMQEANA-------SSSLCVIVFILITVIGKL 800
+ + +L + ++ + W++ M+ + N + + F++ + G
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 801 VVLNLFIALLLNSFSNEER 819
LNLFI +++++F+ +++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKK 1481
Score = 100 bits (249), Expect = 1e-20
Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 47/338 (13%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R ++ H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF + + + W WLD +++ +++VS + LRT R
Sbjct: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V ALL ++ ++NV+++ IF+++G LF G
Sbjct: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1365
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N + E +D + S C E T + NFDN G
Sbjct: 1366 CINYTTGEMFD--------------VSVVNNYSECKALIESNQTARWKNVK-VNFDNVGL 1410
Query: 348 SFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+L++ ++ T W + Q LY +F++ I GSF+ +NL +
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1471 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
Score = 80.5 bits (197), Expect = 1e-14
Identities = 79/338 (23%), Positives = 138/338 (40%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + + N P + + T FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 169
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +I VT +NL + + RT R LR L+ +S
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTIS 229
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGK---------------- 1203
G+K +V ALI ++ + +V+++ + VF ++G+ F G
Sbjct: 230 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289
Query: 1204 ------FGKCINGTDSVINYTI--------ITNKS---------------------QCES 1228
F ++G + N T+ I +KS QC
Sbjct: 290 INITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPE 349
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 350 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 403 -------IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
Score = 59.7 bits (143), Expect = 2e-08
Identities = 47/184 (25%), Positives = 86/184 (46%), Gaps = 22/184 (11%)
Query: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
S P I P N + L I+ +F+++I+ I+ N + M N P K++
Sbjct: 104 SATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPDWTKNV--- 158
Query: 1401 LNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHI 1455
+ F I+T E LIKI F L + F + WN D V+ + V+ ++ L N
Sbjct: 159 -EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVN-LGN---- 212
Query: 1456 PFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILG 1515
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G
Sbjct: 213 ------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIG 266
Query: 1516 MNWF 1519
+ F
Sbjct: 267 LQLF 270
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++K+ ++ + I I+ N VF+ M + + N+ FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 171
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L+ + + R WN D V ++FA V V + LR+FRVLR K
Sbjct: 172 IKILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-NLGNVSALRTFRVLRALKTI 228
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/368 (18%), Positives = 131/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA--TGPAKNSNSNNTDIAECVFTGIYI 171
P N + + +F + I+ + +N V M T +N VF ++
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ + + WN D +V+ ++IV I+ +R
Sbjct: 1576 GECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G N
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1684
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ R+ D F NF+
Sbjct: 1685 VKREV-------GIDDMF---------------------------------------NFE 1698
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVS 1758
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1759 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKL 1818
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1819 SDFADALD 1826
Score = 39.7 bits (91), Expect = 0.027
Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 754 FWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNS 813
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A++ +
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLT--LRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMA 427
Query: 814 FSNEERNGNLEGEARKTKVQLALDRFRR 841
+ + + E E ++ + Q L++ ++
Sbjct: 428 YEEQNQATLEEAEQKEAEFQQMLEQLKK 455
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 27/122 (22%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 359 NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 400
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL ++N+ +AV+ E N AT EE+E E +F E +K
Sbjct: 401 YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 458
Query: 1636 EA 1637
EA
Sbjct: 459 EA 460
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 1302 bits (3370), Expect = 0.0
Identities = 704/1334 (52%), Positives = 929/1334 (69%), Gaps = 98/1334 (7%)
Query: 471 LRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILT 530
L +G+ P G+ ++ + +K+ + S ++S+D + DP RQRA+S SILT
Sbjct: 663 LTSAGQLLPEGTTTETEIRKR-------RSSSYHVSMDLLE---DPTSRQRAMSIASILT 712
Query: 531 ITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIIN 590
TM+E E+S++ C PC A+ L+W+CC WL VK ++ V+ DPF +LAITICI++N
Sbjct: 713 NTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLN 772
Query: 591 TVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL 650
T+F+AMEH+ M F +L++GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD +
Sbjct: 773 TLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVS 832
Query: 651 LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVI 710
LS ++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I
Sbjct: 833 LSLMELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
Query: 711 VIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI 770
++FIF+VVGMQLFG+S+ K+ N L WHM DF+HSFL+VFR+LCGEWI
Sbjct: 891 IVFIFAVVGMQLFGKSYKECVC-KISNDCE-----LPRWHMHDFFHSFLIVFRVLCGEWI 944
Query: 771 ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKT 830
E MW+CM+ A ++C+ VF+++ VIG LVVLNLF+ALLL+SFS++ + +
Sbjct: 945 ETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMN 1001
Query: 831 KVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQN-------LPQQKEVAGGCAAQSK--DI 880
+Q+A+ R ++ FV+ + F K + RKQ L C + +I
Sbjct: 1002 NLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEI 1061
Query: 881 IPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 940
+ +K G+ T +G +SV K + +E D + F + +T P
Sbjct: 1062 GKDLNYLKDGNGTTSGIG--SSVEKYV------------VDESDYMSFINNPSLT-VTVP 1106
Query: 941 EPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL- 999
++ +++ + FS + +++ ++K + TS SE ST+D+
Sbjct: 1107 IAVGES-------------DFENLNTEEFSSESD---MEESKEKLNATSS-SEGSTVDIG 1149
Query: 1000 QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSW 1057
G PE+ P++ +PE C + F CC + + +WWNLRKTCY+IV+H+W
Sbjct: 1150 APAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNW 1209
Query: 1058 FESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKY 1117
FE+FI+F+ILLSSGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF Y
Sbjct: 1210 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY 1269
Query: 1118 FTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNA 1170
FT+AWC LDF+IV VS+ +L L +KS RTLRALRPLRALS+FEGM+VVVNA
Sbjct: 1270 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1329
Query: 1171 LIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES- 1228
L+GAIP+I+NVLLVCLIFWL+F I+GV F+GKF CIN T + + +++ N S+C++
Sbjct: 1330 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL 1389
Query: 1229 ----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLG 1284
W N KVNFDNVG YL+LLQVATFKGWMDI+YAAVDS E QP++E N
Sbjct: 1390 IESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYM 1449
Query: 1285 YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1344
Y+YFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1450 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1509
Query: 1345 QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1404
QKPIPRP NK QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + M +IL +N V
Sbjct: 1510 QKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
F+V+FT EC++K+ +LR YYFT GWN+FD VVV+LSIV ++ L + + PTLFR+
Sbjct: 1570 FIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRV 1627
Query: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
+RLARIGRILRL++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V
Sbjct: 1628 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Query: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS--------KESCNSSSE-NCH 1575
E GIDD+FNF+TF +SM+CLFQI+TSAGWD LL+P+L S K+ SS + +C
Sbjct: 1688 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCG 1747
Query: 1576 LPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDP 1635
P + +FVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP
Sbjct: 1748 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 1807
Query: 1636 EATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLG 1695
+ATQFI+++ LSDFADAL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG
Sbjct: 1808 DATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1867
Query: 1696 GSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK----- 1750
S +D+++ MEE+FM +NP K YEPI TT KRK+EE A IIQ+A+R+Y++K
Sbjct: 1868 ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKK 1927
Query: 1751 ---VTKGDQGDQND 1761
+ K D+G + D
Sbjct: 1928 VSSIYKKDKGKECD 1941
Score = 406 bits (1044), Expect = e-113
Identities = 243/532 (45%), Positives = 317/532 (59%), Gaps = 56/532 (10%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQ--PRPQLDLKASRKLPKLYGD 68
P +FR FT +SLAAIE+RIA +K K+ +++ E + P+P DL+A + LP +YGD
Sbjct: 9 PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGD 68
Query: 69 IPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVH 128
IP E++ PLEDLDP+Y N KTF+VLN+ + I RFSA AL+I PFN IR LAI++ VH
Sbjct: 69 IPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVH 128
Query: 129 SLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
SLF+M I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F
Sbjct: 129 SLFNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDF 184
Query: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
+FLRDPWNWLD VI A V+ + + LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS---------------- 292
SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 293 --------NPEAYDHCFEKK------ENSPEFKMCGIWMGNSACSIQYECKHTKINPDYN 338
+ +D E K E + +CG C Y C NP+Y
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
YT+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYLINL LAV
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 399 VTMAYEEQNKNVAAEIEAKEKMFQE-AQQLLKEEKEALVAM--------------GIDRS 443
V MAYEEQN+ E E KE FQ+ +QL K+++EA A GI
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
Query: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK----DQPPGSDSDEDCQKK 491
S +S S + K K N+++K +SG+ D+ S+S++ ++K
Sbjct: 484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRK 535
Score = 115 bits (287), Expect = 5e-25
Identities = 158/799 (19%), Positives = 308/799 (38%), Gaps = 154/799 (19%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSNNTDIAECVFTGIYI 171
P+ ++ L V + + I +++N +FMA P S+ + VFTGI+
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALK 231
E +KI+A +D + + ++ WN D ++ ++++ L LR+FR+ R K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 291
L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF---------------- 903
Query: 292 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351
++Y C C I +C+ + + +F SFL
Sbjct: 904 --GKSYKEC--------------------VCKISNDCELPR-------WHMHDFFHSFLI 934
Query: 352 MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN---- 407
+FR++ + E ++ + F++V+ +G+ ++NL LA++ ++ N
Sbjct: 935 VFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 994
Query: 408 --KNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKK 465
N ++ Q+ +K + + R E K + NKK
Sbjct: 995 DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI-----KPLEDLNNKK 1049
Query: 466 R---KSFFLRESGKD-----QPPGSDSDEDCQKKPQLLEQTKRLS--------------- 502
+ E GKD G+ S + +++++ +S
Sbjct: 1050 DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAV 1109
Query: 503 -----QNLSLDHFDEHGDPLQRQRALSAVSI---LTITM----------KEQEKSQEPCL 544
+NL+ + F D + + L+A S T+ + E E+S EP
Sbjct: 1110 GESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEA 1169
Query: 545 PCGENLASKYLVWNCC---------PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLA 595
E+ K+ CC W ++K ++ + E I I++++ LA
Sbjct: 1170 CFTEDCVRKF---KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 596 ME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
E + + + + ML + VFT IFI EM LK +A YF W D ++ +S
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSL 1286
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVI 712
+ L ++S R LR + ++ + ++ +GA+ S + V+LV +I
Sbjct: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
Query: 713 F--IFSVVGMQLFGRSF-----------------NSQKSPKLCNPTGPTVSCLRHW---- 749
F IFS++G+ LF F N+ K + T W
Sbjct: 1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTA----RWKNVK 1402
Query: 750 -HMGDFWHSFLVVFRILCGE-WIENMWECMQEANA-------SSSLCVIVFILITVIGKL 800
+ + +L + ++ + W++ M+ + N + + F++ + G
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 801 VVLNLFIALLLNSFSNEER 819
LNLFI +++++F+ +++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKK 1481
Score = 100 bits (249), Expect = 1e-20
Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 47/338 (13%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R ++ H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF + + + W WLD +++ +++VS + LRT R
Sbjct: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V ALL ++ ++NV+++ IF+++G LF G
Sbjct: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1365
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N + E +D + S C E T + NFDN G
Sbjct: 1366 CINYTTGEMFD--------------VSVVNNYSECKALIESNQTARWKNVK-VNFDNVGL 1410
Query: 348 SFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+L++ ++ T W + Q LY +F++ I GSF+ +NL +
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1471 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
Score = 78.6 bits (192), Expect = 5e-14
Identities = 78/338 (23%), Positives = 138/338 (40%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + + N P + + T FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 169
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +I VT ++L + + RT R LR L+ +S
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 229
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGK---------------- 1203
G+K +V ALI ++ + +V+++ + VF ++G+ F G
Sbjct: 230 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289
Query: 1204 ------FGKCINGTDSVINYTI--------ITNKS---------------------QCES 1228
F ++G + N T+ I +KS QC
Sbjct: 290 INITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPE 349
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 350 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 403 -------IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
Score = 59.3 bits (142), Expect = 3e-08
Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 22/184 (11%)
Query: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
S P I P N + L I+ +F+++I+ I+ N + M N P K++
Sbjct: 104 SATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPDWTKNV--- 158
Query: 1401 LNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHI 1455
+ F I+T E LIKI F L + F + WN D V+ + V+ + L N
Sbjct: 159 -EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN---- 212
Query: 1456 PFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILG 1515
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G
Sbjct: 213 ------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIG 266
Query: 1516 MNWF 1519
+ F
Sbjct: 267 LQLF 270
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++K+ ++ + I I+ N VF+ M + + N+ FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 171
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L+ + + R WN D V ++FA V V + LR+FRVLR K
Sbjct: 172 IKILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 228
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/368 (18%), Positives = 131/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA--TGPAKNSNSNNTDIAECVFTGIYI 171
P N + + +F + I+ + +N V M T +N VF ++
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ + + WN D +V+ ++IV I+ +R
Sbjct: 1576 GECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G N
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1684
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ R+ D F NF+
Sbjct: 1685 VKREV-------GIDDMF---------------------------------------NFE 1698
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVS 1758
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1759 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKL 1818
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1819 SDFADALD 1826
Score = 39.7 bits (91), Expect = 0.027
Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 754 FWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNS 813
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A++ +
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLT--LRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMA 427
Query: 814 FSNEERNGNLEGEARKTKVQLALDRFRR 841
+ + + E E ++ + Q L++ ++
Sbjct: 428 YEEQNQATLEEAEQKEAEFQQMLEQLKK 455
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 27/122 (22%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 359 NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 400
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL ++N+ +AV+ E N AT EE+E E +F E +K
Sbjct: 401 YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 458
Query: 1636 EA 1637
EA
Sbjct: 459 EA 460
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 1302 bits (3370), Expect = 0.0
Identities = 704/1334 (52%), Positives = 929/1334 (69%), Gaps = 98/1334 (7%)
Query: 471 LRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILT 530
L +G+ P G+ ++ + +K+ + S ++S+D + DP RQRA+S SILT
Sbjct: 663 LTSAGQLLPEGTTTETEIRKR-------RSSSYHVSMDLLE---DPTSRQRAMSIASILT 712
Query: 531 ITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIIN 590
TM+E E+S++ C PC A+ L+W+CC WL VK ++ V+ DPF +LAITICI++N
Sbjct: 713 NTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLN 772
Query: 591 TVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL 650
T+F+AMEH+ M F +L++GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD +
Sbjct: 773 TLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVS 832
Query: 651 LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVI 710
LS ++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I
Sbjct: 833 LSLMELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
Query: 711 VIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI 770
++FIF+VVGMQLFG+S+ K+ N L WHM DF+HSFL+VFR+LCGEWI
Sbjct: 891 IVFIFAVVGMQLFGKSYKECVC-KISNDCE-----LPRWHMHDFFHSFLIVFRVLCGEWI 944
Query: 771 ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKT 830
E MW+CM+ A ++C+ VF+++ VIG LVVLNLF+ALLL+SFS++ + +
Sbjct: 945 ETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMN 1001
Query: 831 KVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQN-------LPQQKEVAGGCAAQSK--DI 880
+Q+A+ R ++ FV+ + F K + RKQ L C + +I
Sbjct: 1002 NLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEI 1061
Query: 881 IPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 940
+ +K G+ T +G +SV K + +E D + F + +T P
Sbjct: 1062 GKDLNYLKDGNGTTSGIG--SSVEKYV------------VDESDYMSFINNPSLT-VTVP 1106
Query: 941 EPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL- 999
++ +++ + FS + +++ ++K + TS SE ST+D+
Sbjct: 1107 IAVGES-------------DFENLNTEEFSSESD---MEESKEKLNATSS-SEGSTVDIG 1149
Query: 1000 QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSW 1057
G PE+ P++ +PE C + F CC + + +WWNLRKTCY+IV+H+W
Sbjct: 1150 APAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNW 1209
Query: 1058 FESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKY 1117
FE+FI+F+ILLSSGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF Y
Sbjct: 1210 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY 1269
Query: 1118 FTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNA 1170
FT+AWC LDF+IV VS+ +L L +KS RTLRALRPLRALS+FEGM+VVVNA
Sbjct: 1270 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1329
Query: 1171 LIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES- 1228
L+GAIP+I+NVLLVCLIFWL+F I+GV F+GKF CIN T + + +++ N S+C++
Sbjct: 1330 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL 1389
Query: 1229 ----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLG 1284
W N KVNFDNVG YL+LLQVATFKGWMDI+YAAVDS E QP++E N
Sbjct: 1390 IESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYM 1449
Query: 1285 YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1344
Y+YFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1450 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1509
Query: 1345 QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1404
QKPIPRP NK QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + M +IL +N V
Sbjct: 1510 QKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
Query: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
F+V+FT EC++K+ +LR YYFT GWN+FD VVV+LSIV ++ L + + PTLFR+
Sbjct: 1570 FIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRV 1627
Query: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
+RLARIGRILRL++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V
Sbjct: 1628 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Query: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS--------KESCNSSSE-NCH 1575
E GIDD+FNF+TF +SM+CLFQI+TSAGWD LL+P+L S K+ SS + +C
Sbjct: 1688 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCG 1747
Query: 1576 LPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDP 1635
P + +FVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP
Sbjct: 1748 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 1807
Query: 1636 EATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLG 1695
+ATQFI+++ LSDFADAL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG
Sbjct: 1808 DATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1867
Query: 1696 GSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK----- 1750
S +D+++ MEE+FM +NP K YEPI TT KRK+EE A IIQ+A+R+Y++K
Sbjct: 1868 ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKK 1927
Query: 1751 ---VTKGDQGDQND 1761
+ K D+G + D
Sbjct: 1928 VSSIYKKDKGKECD 1941
Score = 406 bits (1044), Expect = e-113
Identities = 243/532 (45%), Positives = 317/532 (59%), Gaps = 56/532 (10%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQ--PRPQLDLKASRKLPKLYGD 68
P +FR FT +SLAAIE+RIA +K K+ +++ E + P+P DL+A + LP +YGD
Sbjct: 9 PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGD 68
Query: 69 IPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVH 128
IP E++ PLEDLDP+Y N KTF+VLN+ + I RFSA AL+I PFN IR LAI++ VH
Sbjct: 69 IPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVH 128
Query: 129 SLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
SLF+M I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F
Sbjct: 129 SLFNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDF 184
Query: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
+FLRDPWNWLD VI A V+ + + LRTFRV RALK ISV+ LK IVGAL++
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS---------------- 292
SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 293 --------NPEAYDHCFEKK------ENSPEFKMCGIWMGNSACSIQYECKHTKINPDYN 338
+ +D E K E + +CG C Y C NP+Y
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
YT+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYLINL LAV
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 399 VTMAYEEQNKNVAAEIEAKEKMFQE-AQQLLKEEKEALVAM--------------GIDRS 443
V MAYEEQN+ E E KE FQ+ +QL K+++EA A GI
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
Query: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK----DQPPGSDSDEDCQKK 491
S +S S + K K N+++K +SG+ D+ S+S++ ++K
Sbjct: 484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRK 535
Score = 115 bits (287), Expect = 5e-25
Identities = 158/799 (19%), Positives = 308/799 (38%), Gaps = 154/799 (19%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSNNTDIAECVFTGIYI 171
P+ ++ L V + + I +++N +FMA P S+ + VFTGI+
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALK 231
E +KI+A +D + + ++ WN D ++ ++++ L LR+FR+ R K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 291
L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF---------------- 903
Query: 292 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351
++Y C C I +C+ + + +F SFL
Sbjct: 904 --GKSYKEC--------------------VCKISNDCELPR-------WHMHDFFHSFLI 934
Query: 352 MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN---- 407
+FR++ + E ++ + F++V+ +G+ ++NL LA++ ++ N
Sbjct: 935 VFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 994
Query: 408 --KNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKK 465
N ++ Q+ +K + + R E K + NKK
Sbjct: 995 DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI-----KPLEDLNNKK 1049
Query: 466 R---KSFFLRESGKD-----QPPGSDSDEDCQKKPQLLEQTKRLS--------------- 502
+ E GKD G+ S + +++++ +S
Sbjct: 1050 DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAV 1109
Query: 503 -----QNLSLDHFDEHGDPLQRQRALSAVSI---LTITM----------KEQEKSQEPCL 544
+NL+ + F D + + L+A S T+ + E E+S EP
Sbjct: 1110 GESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEA 1169
Query: 545 PCGENLASKYLVWNCC---------PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLA 595
E+ K+ CC W ++K ++ + E I I++++ LA
Sbjct: 1170 CFTEDCVRKF---KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
Query: 596 ME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
E + + + + ML + VFT IFI EM LK +A YF W D ++ +S
Sbjct: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSL 1286
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVI 712
+ L ++S R LR + ++ + ++ +GA+ S + V+LV +I
Sbjct: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
Query: 713 F--IFSVVGMQLFGRSF-----------------NSQKSPKLCNPTGPTVSCLRHW---- 749
F IFS++G+ LF F N+ K + T W
Sbjct: 1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTA----RWKNVK 1402
Query: 750 -HMGDFWHSFLVVFRILCGE-WIENMWECMQEANA-------SSSLCVIVFILITVIGKL 800
+ + +L + ++ + W++ M+ + N + + F++ + G
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 801 VVLNLFIALLLNSFSNEER 819
LNLFI +++++F+ +++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKK 1481
Score = 100 bits (249), Expect = 1e-20
Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 47/338 (13%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R ++ H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF + + + W WLD +++ +++VS + LRT R
Sbjct: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V ALL ++ ++NV+++ IF+++G LF G
Sbjct: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1365
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N + E +D + S C E T + NFDN G
Sbjct: 1366 CINYTTGEMFD--------------VSVVNNYSECKALIESNQTARWKNVK-VNFDNVGL 1410
Query: 348 SFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+L++ ++ T W + Q LY +F++ I GSF+ +NL +
Sbjct: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1471 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
Score = 78.6 bits (192), Expect = 5e-14
Identities = 78/338 (23%), Positives = 138/338 (40%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + + N P + + T FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 169
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +I VT ++L + + RT R LR L+ +S
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 229
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGK---------------- 1203
G+K +V ALI ++ + +V+++ + VF ++G+ F G
Sbjct: 230 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289
Query: 1204 ------FGKCINGTDSVINYTI--------ITNKS---------------------QCES 1228
F ++G + N T+ I +KS QC
Sbjct: 290 INITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPE 349
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 350 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 403 -------IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
Score = 59.3 bits (142), Expect = 3e-08
Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 22/184 (11%)
Query: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
S P I P N + L I+ +F+++I+ I+ N + M N P K++
Sbjct: 104 SATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPDWTKNV--- 158
Query: 1401 LNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHI 1455
+ F I+T E LIKI F L + F + WN D V+ + V+ + L N
Sbjct: 159 -EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN---- 212
Query: 1456 PFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILG 1515
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G
Sbjct: 213 ------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIG 266
Query: 1516 MNWF 1519
+ F
Sbjct: 267 LQLF 270
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++K+ ++ + I I+ N VF+ M + + N+ FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 171
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L+ + + R WN D V ++FA V V + LR+FRVLR K
Sbjct: 172 IKILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 228
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/368 (18%), Positives = 131/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA--TGPAKNSNSNNTDIAECVFTGIYI 171
P N + + +F + I+ + +N V M T +N VF ++
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ + + WN D +V+ ++IV I+ +R
Sbjct: 1576 GECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G N
Sbjct: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1684
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ R+ D F NF+
Sbjct: 1685 VKREV-------GIDDMF---------------------------------------NFE 1698
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVS 1758
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1759 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKL 1818
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1819 SDFADALD 1826
Score = 39.7 bits (91), Expect = 0.027
Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 754 FWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNS 813
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A++ +
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLT--LRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMA 427
Query: 814 FSNEERNGNLEGEARKTKVQLALDRFRR 841
+ + + E E ++ + Q L++ ++
Sbjct: 428 YEEQNQATLEEAEQKEAEFQQMLEQLKK 455
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 27/122 (22%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 359 NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 400
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL ++N+ +AV+ E N AT EE+E E +F E +K
Sbjct: 401 YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 458
Query: 1636 EA 1637
EA
Sbjct: 459 EA 460
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 1301 bits (3367), Expect = 0.0
Identities = 696/1268 (54%), Positives = 895/1268 (70%), Gaps = 67/1268 (5%)
Query: 511 DEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVL 570
D DP RQRA+S SILT T++E E+S++ C P A K+L+WNC P W+ KK +
Sbjct: 667 DMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCI 726
Query: 571 RTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 630
++ DPF +LAITICI++NT+F+AMEHH M F+ +L IGNLVFT IF AEM LK+IA
Sbjct: 727 YFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIA 786
Query: 631 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTL 690
+DPY YF+ GWNIFDS++ LS ++ ++ S LRSFR+LRVFKLAKSWPTLN L
Sbjct: 787 MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLS--VLRSFRLLRVFKLAKSWPTLNML 844
Query: 691 IKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWH 750
IKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+ K C L WH
Sbjct: 845 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY------KECVCKINDDCTLPRWH 898
Query: 751 MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALL 810
M DF+HSFL+VFR+LCGEWIE MW+CM+ A ++C+IV++++ VIG LVVLNLF+ALL
Sbjct: 899 MNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVYMMVMVIGNLVVLNLFLALL 956
Query: 811 LNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQNLPQQKEV 869
L+SFS++ +E + +Q+A+ R ++ +V+ TL F K + +K + ++
Sbjct: 957 LSSFSSDNLTA-IEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQ 1015
Query: 870 AGGCAAQSKDIIP--LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVE 927
A + ++ I + EM +G +E ++ ++ +H L E+ D
Sbjct: 1016 AEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVD-KH-------LMEDSDGQS 1067
Query: 928 FSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDV 987
F + + +T P ++ +L N + S D + ++ R S
Sbjct: 1068 FI-HNPSLTVTVPIAPGES-DLENMNAEELSS----------DSDSEYSKVRLNRSSS-- 1113
Query: 988 TSILSECSTIDLQ-DGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWN 1044
SECST+D G G E P +PE C G F CC V+ IWWN
Sbjct: 1114 ----SECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RKTCY+IV+HSWFESFI+ +ILLSSGAL FED+++E + I+ +L D IFT+IFILE
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 1105 MVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRA 1157
M+LKW+A+G+ YFT+AWC LDF+IV VS+ TL+ +L +KS RTLRALRPLRA
Sbjct: 1230 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1289
Query: 1158 LSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTD-SVIN 1216
LS+FEGM+VVVNALIGAIP+I+NVLLVCLIFWL+F I+GV F+GKF +CIN TD S
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFP 1349
Query: 1217 YTIITNKSQC-----ESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
+ + N+S+C S N W N KVNFDNVG YL+LLQVATFKGW I+YAAVDS
Sbjct: 1350 ASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVN 1409
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
++QP++E + YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEEQKK
Sbjct: 1410 VDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1469
Query: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
YYNAMKKLGSKKPQKPIPRP NK QG +FD+VT+Q FDI I+ LI LNM++MM E Q
Sbjct: 1470 YYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQS 1529
Query: 1392 KAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLEN 1451
+ M +L +N VF+++FT EC++K+ +LR YYFT GWN+FD VVV++SIV ++ L
Sbjct: 1530 QHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIE 1589
Query: 1452 QEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIY 1511
+ PTLFR++RLARIGRILRLV+ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIY
Sbjct: 1590 TYFV--SPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1647
Query: 1512 AILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK-ESC--- 1567
AI GM+ F+ V E GI+D+FNF+TF +SM+CLFQI+TSAGWD LL+P+L SK C
Sbjct: 1648 AIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPK 1707
Query: 1568 -----NSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDD 1622
+S +C P + YFVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDD
Sbjct: 1708 KVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDD 1767
Query: 1623 FDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHC 1682
F++FYEVWEKFDP+ATQFI++S LSDFA AL PL +AKPNK Q + MDLPMVS DR+HC
Sbjct: 1768 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1827
Query: 1683 MDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQK 1742
+DILFAFT RVLG S +DS+++ MEE+FM ANP K YEPI TT KRK+E+ A +IQ+
Sbjct: 1828 LDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQR 1887
Query: 1743 AFRKYMMK 1750
A+R+Y ++
Sbjct: 1888 AYRRYRLR 1895
Score = 416 bits (1070), Expect = e-116
Identities = 230/481 (47%), Positives = 309/481 (64%), Gaps = 29/481 (6%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKK-KSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
P ++F FT SLA IE+RIA +K K+ K + + + P+P DL+A ++LP +YGDI
Sbjct: 7 PGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDI 66
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P ++ +PLEDLDP+Y + KTF+VLN+ +TI+RF+A AL++ PF+ +R ++I++ VHS
Sbjct: 67 PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LFSM I+ T++ NC+FM N+ + T E FTGIY FE+L+KILARGF + EF+
Sbjct: 127 LFSMLIMCTILTNCIFMTM----NNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFT 182
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD +VI A ++ + + LRTFRV RALK ISV+ LK IVGAL++S
Sbjct: 183 FLRDPWNWLDFVVIVFAYLTEFVNLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKEN--- 306
VKKL +V+ILT FCLS+FAL+G QLFMG+L KC +N E+ + E +E+
Sbjct: 242 VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRK 301
Query: 307 -------SPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQD 359
S + +CG + C Y C NPDY YT+FD F W+FLA+FRLMTQD
Sbjct: 302 YFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQD 361
Query: 360 SWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEK 419
WE LYQQTLR G + FF+VVIFLGSFYLINL LAVV MAYEEQN+ E + KE
Sbjct: 362 YWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKEL 421
Query: 420 MFQEAQQLLK---EEKEALVAMGIDRSSL----------TSLETSYFTPKKRKLFGNKKR 466
FQ+ LK EE EA+ A + +S+ +S ETS + K K N+++
Sbjct: 422 EFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRK 481
Query: 467 K 467
K
Sbjct: 482 K 482
Score = 118 bits (296), Expect = 5e-26
Identities = 160/806 (19%), Positives = 312/806 (38%), Gaps = 142/806 (17%)
Query: 101 YRFSAKHALFIFGPF-NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSN 157
YRF+ K ++ P+ + + + + I +++N +FMA P N
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763
Query: 158 NTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK 217
I VFTGI+ E ++K++A +D + + + WN DS+++ +++V
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819
Query: 218 LLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
L LR+FR+ R K L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-- 877
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
++Y C C I +C +
Sbjct: 878 ----------------GKSYKEC--------------------VCKINDDCTLPR----- 896
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+ ++F SFL +FR++ + E ++ + +++V+ +G+ ++NL LA
Sbjct: 897 --WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLA 954
Query: 398 VVTMAYEEQN----------KNVAAEIEAKEKMFQEAQQLLKE------EKEALVAMGID 441
++ ++ N N+ + +K +Q L+E K+ ++ I
Sbjct: 955 LLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIR 1014
Query: 442 RS-SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQK---------- 490
++ L + + +Y + + FL+E K GS D+ +
Sbjct: 1015 QAEDLNTKKENYIS---NHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHN 1071
Query: 491 ---------KPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITM-------- 533
P + ++ LS D E+ + + S S + +
Sbjct: 1072 PSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAE 1131
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQ---------WLCVKKVLRTVMTDPFTELAIT 584
E S EP + ++ +CC W ++K ++ + E I
Sbjct: 1132 AEPMNSDEPEACFTDGCVRRF---SCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIV 1188
Query: 585 ICIIINTVFLAME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWN 642
+ I++++ LA E + + + + + +L + +FT IFI EM LK IA YF W
Sbjct: 1189 LMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWC 1248
Query: 643 IFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALG 702
D ++ +S ++ L ++S R LR + ++ + ++ +GA+
Sbjct: 1249 WLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIP 1308
Query: 703 S-LTVVLVIVIF--IFSVVGMQLFGRSF-------NSQKSPKLCNPTGPTVSCLRHWHMG 752
S + V+LV +IF IFS++G+ LF F + + P P L +
Sbjct: 1309 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQN 1368
Query: 753 DFWHSFLVVF-RILCG-----------EWIENMWECMQEANAS-------SSLCVIVFIL 793
W + V F + G W M+ + N S I F++
Sbjct: 1369 VRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVV 1428
Query: 794 ITVIGKLVVLNLFIALLLNSFSNEER 819
+ G LNLFI +++++F+ +++
Sbjct: 1429 FIIFGSFFTLNLFIGVIIDNFNQQKK 1454
Score = 99.8 bits (247), Expect = 2e-20
Identities = 78/338 (23%), Positives = 155/338 (45%), Gaps = 47/338 (13%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIF 172
+IR ++ HS F FI+ ++++ +A I A+ +FT I+I
Sbjct: 1169 NIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A G+ ++ + W WLD +++ +++V+ + + LRT R
Sbjct: 1229 EMLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1284
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G +
Sbjct: 1285 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YE 1338
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N ++ + P C M N + ++++ K+ K+ NFDN G
Sbjct: 1339 CINTTDGSRF-----PASQVPNRSECFALM-NVSQNVRW--KNLKV-------NFDNVGL 1383
Query: 348 SFLAMFRLMTQDSWE----------KLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+L++ ++ T W + +Q LY +F+V I GSF+ +NL +
Sbjct: 1384 GYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIG 1443
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + + ++K + A + L +K
Sbjct: 1444 VIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1481
Score = 86.7 bits (213), Expect = 2e-16
Identities = 76/315 (24%), Positives = 137/315 (43%), Gaps = 62/315 (19%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
LR+ +I+ HS F I+ IL + IF + + N P + + T FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLIMCTILTNC---IF--MTMNNPPDWTKNVEYT---FTGIYTFE 166
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF++++ + +T +NL + + RT R LR L+ +S
Sbjct: 167 SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTIS 226
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG----------------- 1202
G+K +V ALI ++ + +V+++ + VF ++G+ F G
Sbjct: 227 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETL 286
Query: 1203 --------------KFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVN-------FD 1241
K+ + G+ + T+ QC G ++ + N FD
Sbjct: 287 ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG-YTCVKIGRNPDYGYTSFD 345
Query: 1242 NVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLN 1301
A+LAL ++ T W ++ + + K I+FVV I GSF+ +N
Sbjct: 346 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM----------IFFVVVIFLGSFYLIN 395
Query: 1302 LFIGVIIDNFNQQQK 1316
L + V+ + +Q +
Sbjct: 396 LILAVVAMAYEEQNQ 410
Score = 70.5 bits (171), Expect = 1e-11
Identities = 65/331 (19%), Positives = 139/331 (41%), Gaps = 68/331 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++++ ++ + I I+ N +F+ M + + N+ FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP-----DWTKNV-EYTFTGIYTFESL 168
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A + + + R WN D +V + ++ + + + LR+FRVLR K
Sbjct: 169 VKILARGFCVGEFTFLRDPWNWLDFVVIVFAY---LTEFVNLGNVSALRTFRVLRALKTI 225
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRS--------------- 726
P L T++ + SV L + ++ V + +F+++G+QLF +
Sbjct: 226 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET 285
Query: 727 --------------------FNSQKSPKLCN--------PTGPTVSCLRHWHMGDFWH-- 756
K LC P G T C++ D+ +
Sbjct: 286 LESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYT--CVKIGRNPDYGYTS 343
Query: 757 ------SFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALL 810
+FL +FR++ ++ EN+++ Q A+ +I F+++ +G ++NL +A++
Sbjct: 344 FDTFSWAFLALFRLMTQDYWENLYQ--QTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401
Query: 811 LNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
++ + + E + ++ + Q LDR ++
Sbjct: 402 AMAYEEQNQANIEEAKQKELEFQQMLDRLKK 432
Score = 55.1 bits (131), Expect = 6e-07
Identities = 46/192 (23%), Positives = 90/192 (46%), Gaps = 29/192 (15%)
Query: 1333 YNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPK 1392
+NA L P P+ R + I+ +F ++I+ I+ N I M N P
Sbjct: 100 FNATPALYMLSPFSPLRR-------ISIKILVHSLFSMLIMCTILTNCIFMTMN--NPPD 150
Query: 1393 AMKSILDHLNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMIS 1447
K++ + F I+T E L+KI F + ++ F + WN D VV++ + ++ ++
Sbjct: 151 WTKNV----EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN 206
Query: 1448 TLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLI 1507
L N +R R+ R L+ + G++T++ AL+ S+ L ++ +L
Sbjct: 207 -LGN----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFC 255
Query: 1508 MFIYAILGMNWF 1519
+ ++A++G+ F
Sbjct: 256 LSVFALIGLQLF 267
Score = 47.4 bits (111), Expect = 1e-04
Identities = 70/369 (18%), Positives = 139/369 (37%), Gaps = 99/369 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIA---ECVFTGIY 170
P N I+ + + F + I+ + +N V M + + + T++ VF ++
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV-EKEGQSQHMTEVLYWINVVFIILF 1547
Query: 171 IFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLL--------PLR 222
E ++K+++ L + F WN D +V+ I+IV I+ +R
Sbjct: 1548 TGECVLKLIS----LRHYYFTVG-WNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIR 1602
Query: 223 TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
R+ R L+ + ++ ++ AL+ S+ L N+ +L F + I+A+ G F
Sbjct: 1603 LARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------- 1655
Query: 283 CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342
+ KKE+ IN +N F
Sbjct: 1656 -----------------AYVKKEDG-------------------------INDMFN---F 1670
Query: 343 DNFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFI 381
+ FG S + +F++ T W+ L L + +F+F+
Sbjct: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
Query: 382 VVIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEK 432
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSK 1790
Query: 433 EALVAMGID 441
+ A +D
Sbjct: 1791 LSDFAAALD 1799
Score = 31.6 bits (70), Expect = 7.2
Identities = 20/84 (23%), Positives = 40/84 (47%), Gaps = 21/84 (25%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 336 NPDYGYT---SFDTFSWAFLALFRLMTQDYWENLYQQTLRA---------------AGKT 377
Query: 1583 YFVSYIIISFL---IVVNMYIAVI 1603
Y + ++++ FL ++N+ +AV+
Sbjct: 378 YMIFFVVVIFLGSFYLINLILAVV 401
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 1292 bits (3344), Expect = 0.0
Identities = 710/1360 (52%), Positives = 927/1360 (68%), Gaps = 102/1360 (7%)
Query: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSD---------EDCQKKPQL 494
SL S+ S F+P++ N K F R KD GS++D ED + +
Sbjct: 558 SLLSIRGSLFSPRR-----NSKTSIFSFRGRAKDV--GSENDFADDEHSTFEDSESRRDS 610
Query: 495 L--------------------EQTKRLSQ-NLSLDHFDEHGDPLQRQRALSAVSILTITM 533
L + +RLS +S++ + D RQRA+S SILT TM
Sbjct: 611 LFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLE---DSSGRQRAVSIASILTNTM 667
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
+E E+S++ C PC A+ +L+W+CC WL VK ++ ++ DPF +LAITICI++NT+F
Sbjct: 668 EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLF 727
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH+ M F +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD I+ LS
Sbjct: 728 MAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSL 787
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIF 713
++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++F
Sbjct: 788 MELGLSNVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 845
Query: 714 IFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENM 773
IF+VVGMQLFG+S+ K C L WHM DF+HSFL+VFR+LCGEWIE M
Sbjct: 846 IFAVVGMQLFGKSY------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 899
Query: 774 WECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQ 833
W+CM+ A ++C+IVF+L+ VIG LVVLNLF+ALLL+SFS++ + + +Q
Sbjct: 900 WDCMEVAG--QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQ 956
Query: 834 LALDRFRRAFCFVRHTL-EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSE 892
+A+ R ++ +V++ + E F + RK P+ E+ G S M G E
Sbjct: 957 IAVGRMQKGIDYVKNKMRECFQKAFFRK---PKVIEIHEGNKIDS------CMSNNTGIE 1007
Query: 893 TQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQE 952
+EL L T + + +E+D + + +T P ++
Sbjct: 1008 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGES------ 1061
Query: 953 NKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL---QDGFGWLPEM 1009
+++ + FS + +++ ++K + TS SE ST+D+ ++G E
Sbjct: 1062 -------DFENLNTEEFSSESE---LEESKEKLNATSS-SEGSTVDVVLPREGEQAETEP 1110
Query: 1010 VPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLS 1069
+PE C +G FP C V + IWWNLRKTCY IV+H+WFE+FI+F+ILLS
Sbjct: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170
Query: 1070 SGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1129
SGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF YFT+AWC LDF+I
Sbjct: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230
Query: 1130 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVL 1182
V VS+ +L+ L +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVL
Sbjct: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290
Query: 1183 LVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES--GNFSWINQKVN 1239
LVCLIFWL+F I+GV F+GKF C+N T ++ + + + N S C++ W N KVN
Sbjct: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299
FDNVG YLALLQVATFKGWMDI+YAAVDS + + QP +E N Y+YFV+FIIFGSFFT
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
LNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMV 1470
Query: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
FD VT Q+FDI I+ LI LNM++MM E+ +Q K M +L +N VF+V+FT E ++K+ +
Sbjct: 1471 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS 1530
Query: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
LR YYFT GWN+FD VVV+LSIV ++ + + + PTLFR++RLARIGRILRL++
Sbjct: 1531 LRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV--SPTLFRVIRLARIGRILRLIKG 1588
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V E+GIDD+FNF+TF +
Sbjct: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648
Query: 1540 SMLCLFQISTSAGWDSLLSPMLRS-KESC--------NSSSENCHLPGIATSYFVSYIII 1590
SM+CLFQI+TSAGWD LL+P+L S C +S +C P + +FVSYIII
Sbjct: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
Query: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650
SFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQFI++S LSDFA
Sbjct: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768
Query: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710
AL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG S +D+++ ME++
Sbjct: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828
Query: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
FM +NP K YEPI TT KRK+EE AAIIQ+ FR Y++K
Sbjct: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLK 1868
Score = 410 bits (1053), Expect = e-114
Identities = 239/543 (44%), Positives = 318/543 (58%), Gaps = 54/543 (9%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-QPRPQLDLKASRKLPKLYGDI 69
P +FR FT +SLAAIEKR A +K KK K+Q + +P+P DL+A + LP +YGDI
Sbjct: 9 PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P E++ +PLEDLDP+Y N KTF+V+N+ + I+RFSA AL+I P N +R +AI++ VHS
Sbjct: 69 PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LFSM I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F+
Sbjct: 129 LFSMLIMCTILTNCVFMTLSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFT 184
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A V+ + + LRTFRV RALK ISV+ LK IVGAL++S
Sbjct: 185 FLRDPWNWLDFSVIVMAYVTEFVSLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCIS---RDCKNISNPEAY--------- 297
VKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ D +N +Y
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 298 ------------------DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
D F + + +CG C Y C NP+Y Y
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 340 TNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVV 399
T+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYL+NL LAVV
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 400 TMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAM--------------GIDRSSL 445
MAYEEQN+ E E KE FQ+ + LK+++E A+ G+
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
Query: 446 TSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 505
+S E S + K K + N+++K R + + + D K + + KR S
Sbjct: 484 SSSEASKLSSKSAKEWRNRRKK----RRQREHLEGNNKGERDSFPKSESEDSVKRSSFLF 539
Query: 506 SLD 508
S+D
Sbjct: 540 SMD 542
Score = 100 bits (250), Expect = 1e-20
Identities = 78/338 (23%), Positives = 151/338 (44%), Gaps = 50/338 (14%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R + H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1145 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1204
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF ++ + W WLD +++ +++VS + + LRT R
Sbjct: 1205 EMLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1314
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N++ +D N + + G Q K+ K+ NFDN G
Sbjct: 1315 CVNMTTGNMFD--ISDVNNLSDCQALG---------KQARWKNVKV-------NFDNVGA 1356
Query: 348 SFLAMFRLMTQDSWEKLYQ----------QTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+LA+ ++ T W + Q + LY +F++ I GSF+ +NL +
Sbjct: 1357 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIG 1416
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1417 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1454
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + L N P + + T FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNC---VF--MTLSNPPDWTKNVEYT---FTGIYTFE 168
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +IV+ VT ++L + + RT R LR L+ +S
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTIS 228
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+
Sbjct: 229 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFE 288
Query: 1209 -------NGT----DSVINYTIIT-----------------------------NKSQCES 1228
NGT + +N T+ T + QC
Sbjct: 289 TNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPE 348
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 349 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM--- 401
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 402 -------IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 59/275 (21%)
Query: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA P S+ + VFTGI+ E ++KI+A +D + + ++ WN
Sbjct: 721 IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWN 776
Query: 197 WLDSIVIGIAIV----SYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK 252
D I++ ++++ S + G+++ LR+FR+ R K L +++ + SV
Sbjct: 777 IFDGIIVSLSLMELGLSNVEGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 832
Query: 253 LVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKM 312
L N+ ++ + IFA+VG QLF ++Y C
Sbjct: 833 LGNLTLVLAIIVFIFAVVGMQLF------------------GKSYKEC------------ 862
Query: 313 CGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C I +C + + ++F SFL +FR++ + E ++
Sbjct: 863 --------VCKINDDCTLPR-------WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 907
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
+ F++V+ +G+ ++NL LA++ ++ N
Sbjct: 908 QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDN 942
Score = 60.8 bits (146), Expect = 1e-08
Identities = 45/174 (25%), Positives = 85/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
PLN + + I+ +F ++I+ I+ N + M N P K++ + F I+T
Sbjct: 113 PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPPDWTKNV----EYTFTGIYT 166
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E LIKI F L + F + WN D V++++ V+ +S L N +
Sbjct: 167 FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVS-LGN----------VSAL 215
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 216 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 58.2 bits (139), Expect = 7e-08
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 13/162 (8%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
V+K+ ++ + I I+ N VF+ + + + N+ FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESL 170
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KI+A L+ + + R WN D V ++++ + + LR+FRVLR K
Sbjct: 171 IKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF---VSLGNVSALRTFRVLRALKTI 227
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 42.4 bits (98), Expect = 0.004
Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + +F + I+ + +N V M ++ VF ++
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ L + F WN D +V+ ++IV I+ +R
Sbjct: 1522 GEFVLKLVS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G F
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------- 1628
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ KKE + + NF+
Sbjct: 1629 ----------------AYVKKEAGID----------------------------DMFNFE 1644
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1645 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVS 1704
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1705 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1764
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1765 SDFAAALD 1772
Score = 35.4 bits (80), Expect = 0.50
Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 28/136 (20%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 358 NPNYGYT---SFDTFSWAFLSLFRLMTQDYWENLYQLTLRA---------------AGKT 399
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL +VN+ +AV+ E N AT EE+E E +F E +K
Sbjct: 400 YMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 457
Query: 1636 EATQFIKYSALS-DFA 1650
EA SA S DF+
Sbjct: 458 EAQAVAAASAASRDFS 473
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 1292 bits (3344), Expect = 0.0
Identities = 710/1360 (52%), Positives = 927/1360 (68%), Gaps = 102/1360 (7%)
Query: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSD---------EDCQKKPQL 494
SL S+ S F+P++ N K F R KD GS++D ED + +
Sbjct: 558 SLLSIRGSLFSPRR-----NSKTSIFSFRGRAKDV--GSENDFADDEHSTFEDSESRRDS 610
Query: 495 L--------------------EQTKRLSQ-NLSLDHFDEHGDPLQRQRALSAVSILTITM 533
L + +RLS +S++ + D RQRA+S SILT TM
Sbjct: 611 LFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLE---DSSGRQRAVSIASILTNTM 667
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
+E E+S++ C PC A+ +L+W+CC WL VK ++ ++ DPF +LAITICI++NT+F
Sbjct: 668 EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLF 727
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH+ M F +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD I+ LS
Sbjct: 728 MAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSL 787
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIF 713
++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++F
Sbjct: 788 MELGLSNVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 845
Query: 714 IFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENM 773
IF+VVGMQLFG+S+ K C L WHM DF+HSFL+VFR+LCGEWIE M
Sbjct: 846 IFAVVGMQLFGKSY------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 899
Query: 774 WECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQ 833
W+CM+ A ++C+IVF+L+ VIG LVVLNLF+ALLL+SFS++ + + +Q
Sbjct: 900 WDCMEVAG--QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQ 956
Query: 834 LALDRFRRAFCFVRHTL-EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSE 892
+A+ R ++ +V++ + E F + RK P+ E+ G S M G E
Sbjct: 957 IAVGRMQKGIDYVKNKMRECFQKAFFRK---PKVIEIHEGNKIDS------CMSNNTGIE 1007
Query: 893 TQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQE 952
+EL L T + + +E+D + + +T P ++
Sbjct: 1008 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGES------ 1061
Query: 953 NKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL---QDGFGWLPEM 1009
+++ + FS + +++ ++K + TS SE ST+D+ ++G E
Sbjct: 1062 -------DFENLNTEEFSSESE---LEESKEKLNATSS-SEGSTVDVVLPREGEQAETEP 1110
Query: 1010 VPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLS 1069
+PE C +G FP C V + IWWNLRKTCY IV+H+WFE+FI+F+ILLS
Sbjct: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170
Query: 1070 SGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1129
SGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF YFT+AWC LDF+I
Sbjct: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230
Query: 1130 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVL 1182
V VS+ +L+ L +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVL
Sbjct: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290
Query: 1183 LVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES--GNFSWINQKVN 1239
LVCLIFWL+F I+GV F+GKF C+N T ++ + + + N S C++ W N KVN
Sbjct: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
Query: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299
FDNVG YLALLQVATFKGWMDI+YAAVDS + + QP +E N Y+YFV+FIIFGSFFT
Sbjct: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
Query: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
LNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V
Sbjct: 1411 LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMV 1470
Query: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
FD VT Q+FDI I+ LI LNM++MM E+ +Q K M +L +N VF+V+FT E ++K+ +
Sbjct: 1471 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS 1530
Query: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
LR YYFT GWN+FD VVV+LSIV ++ + + + PTLFR++RLARIGRILRL++
Sbjct: 1531 LRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV--SPTLFRVIRLARIGRILRLIKG 1588
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V E+GIDD+FNF+TF +
Sbjct: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648
Query: 1540 SMLCLFQISTSAGWDSLLSPMLRS-KESC--------NSSSENCHLPGIATSYFVSYIII 1590
SM+CLFQI+TSAGWD LL+P+L S C +S +C P + +FVSYIII
Sbjct: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
Query: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650
SFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQFI++S LSDFA
Sbjct: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768
Query: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710
AL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG S +D+++ ME++
Sbjct: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828
Query: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
FM +NP K YEPI TT KRK+EE AAIIQ+ FR Y++K
Sbjct: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLK 1868
Score = 409 bits (1052), Expect = e-113
Identities = 239/543 (44%), Positives = 318/543 (58%), Gaps = 54/543 (9%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-QPRPQLDLKASRKLPKLYGDI 69
P +FR FT +SLAAIEKR A +K KK K+Q + +P+P DL+A + LP +YGDI
Sbjct: 9 PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P E++ +PLEDLDP+Y N KTF+V+N+ + I+RFSA AL+I P N +R +AI++ VHS
Sbjct: 69 PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LFSM I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F+
Sbjct: 129 LFSMLIMCTILTNCVFMTLSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFT 184
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A V+ + + LRTFRV RALK ISV+ LK IVGAL++S
Sbjct: 185 FLRDPWNWLDFSVIVMAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCIS---RDCKNISNPEAY--------- 297
VKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ D +N +Y
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 298 ------------------DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
D F + + +CG C Y C NP+Y Y
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 340 TNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVV 399
T+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYL+NL LAVV
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 400 TMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAM--------------GIDRSSL 445
MAYEEQN+ E E KE FQ+ + LK+++E A+ G+
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
Query: 446 TSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 505
+S E S + K K + N+++K R + + + D K + + KR S
Sbjct: 484 SSSEASKLSSKSAKEWRNRRKK----RRQREHLEGNNKGERDSFPKSESEDSVKRSSFLF 539
Query: 506 SLD 508
S+D
Sbjct: 540 SMD 542
Score = 100 bits (250), Expect = 1e-20
Identities = 78/338 (23%), Positives = 151/338 (44%), Gaps = 50/338 (14%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R + H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1145 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1204
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF ++ + W WLD +++ +++VS + + LRT R
Sbjct: 1205 EMLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1314
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N++ +D N + + G Q K+ K+ NFDN G
Sbjct: 1315 CVNMTTGNMFD--ISDVNNLSDCQALG---------KQARWKNVKV-------NFDNVGA 1356
Query: 348 SFLAMFRLMTQDSWEKLYQ----------QTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+LA+ ++ T W + Q + LY +F++ I GSF+ +NL +
Sbjct: 1357 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIG 1416
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1417 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1454
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + L N P + + T FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNC---VF--MTLSNPPDWTKNVEYT---FTGIYTFE 168
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +IV+ VT ++L + + RT R LR L+ +S
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTIS 228
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+
Sbjct: 229 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFE 288
Query: 1209 -------NGT----DSVINYTIIT-----------------------------NKSQCES 1228
NGT + +N T+ T + QC
Sbjct: 289 TNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPE 348
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 349 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM--- 401
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 402 -------IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 59/275 (21%)
Query: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA P S+ + VFTGI+ E ++KI+A +D + + ++ WN
Sbjct: 721 IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWN 776
Query: 197 WLDSIVIGIAIV----SYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK 252
D I++ ++++ S + G+++ LR+FR+ R K L +++ + SV
Sbjct: 777 IFDGIIVSLSLMELGLSNVEGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 832
Query: 253 LVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKM 312
L N+ ++ + IFA+VG QLF ++Y C
Sbjct: 833 LGNLTLVLAIIVFIFAVVGMQLF------------------GKSYKEC------------ 862
Query: 313 CGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C I +C + + ++F SFL +FR++ + E ++
Sbjct: 863 --------VCKINDDCTLPR-------WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 907
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
+ F++V+ +G+ ++NL LA++ ++ N
Sbjct: 908 QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDN 942
Score = 59.3 bits (142), Expect = 3e-08
Identities = 44/174 (25%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
PLN + + I+ +F ++I+ I+ N + M N P K++ + F I+T
Sbjct: 113 PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPPDWTKNV----EYTFTGIYT 166
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E LIKI F L + F + WN D V++++ V+ + L N +
Sbjct: 167 FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD-LGN----------VSAL 215
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 216 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 58.5 bits (140), Expect = 6e-08
Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 21/166 (12%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
V+K+ ++ + I I+ N VF+ + + + N+ FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESL 170
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677
+KI+A L+ + + R WN D V +++ F D+ N LR+FRVLR
Sbjct: 171 IKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-------LRTFRVLRA 223
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
K P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 42.4 bits (98), Expect = 0.004
Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + +F + I+ + +N V M ++ VF ++
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ L + F WN D +V+ ++IV I+ +R
Sbjct: 1522 GEFVLKLVS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G F
Sbjct: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------- 1628
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ KKE + + NF+
Sbjct: 1629 ----------------AYVKKEAGID----------------------------DMFNFE 1644
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1645 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVS 1704
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1705 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1764
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1765 SDFAAALD 1772
Score = 35.4 bits (80), Expect = 0.50
Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 28/136 (20%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 358 NPNYGYT---SFDTFSWAFLSLFRLMTQDYWENLYQLTLRA---------------AGKT 399
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL +VN+ +AV+ E N AT EE+E E +F E +K
Sbjct: 400 YMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 457
Query: 1636 EATQFIKYSALS-DFA 1650
EA SA S DF+
Sbjct: 458 EAQAVAAASAASRDFS 473
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 1292 bits (3344), Expect = 0.0
Identities = 694/1300 (53%), Positives = 910/1300 (70%), Gaps = 72/1300 (5%)
Query: 474 SGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITM 533
+G+ P G+ ++ + +K+ + S +S++ + D RQRA+S SILT TM
Sbjct: 667 TGQLPPEGTTTETEVRKR-------RLSSYQISMEMLE---DSSGRQRAVSIASILTNTM 716
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
+E E+S++ C PC A+ +L+W+CC WL VK ++ ++ DPF +LAITICI++NT+F
Sbjct: 717 EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLF 776
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH+ M F +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD I+ LS
Sbjct: 777 MAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSL 836
Query: 654 ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIF 713
++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++F
Sbjct: 837 MELGLSNVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 894
Query: 714 IFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENM 773
IF+VVGMQLFG+S+ K C L WHM DF+HSFL+VFR+LCGEWIE M
Sbjct: 895 IFAVVGMQLFGKSY------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
Query: 774 WECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQ 833
W+CM+ A ++C+IVF+L+ VIG LVVLNLF+ALLL+SFS++ + + +Q
Sbjct: 949 WDCMEVAG--QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQ 1005
Query: 834 LALDRFRRAFCFVRHTL-EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSE 892
+A+ R ++ +V++ + E F + RK P+ E+ G S M G E
Sbjct: 1006 IAVGRMQKGIDYVKNKMRECFQKAFFRK---PKVIEIHEGNKIDS------CMSNNTGIE 1056
Query: 893 TQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQE 952
+EL L T + + +E+D + + +T P ++
Sbjct: 1057 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGES------ 1110
Query: 953 NKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL---QDGFGWLPEM 1009
+++ + FS + +++ ++K + TS SE ST+D+ ++G E
Sbjct: 1111 -------DFENLNTEEFSSESE---LEESKEKLNATSS-SEGSTVDVVLPREGEQAETEP 1159
Query: 1010 VPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLS 1069
+PE C +G FP C V + IWWNLRKTCY IV+H+WFE+FI+F+ILLS
Sbjct: 1160 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1219
Query: 1070 SGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1129
SGAL FED+++E + I+ +L D +FT+IFILEM+LKWVA+GF YFT+AWC LDF+I
Sbjct: 1220 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1279
Query: 1130 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVL 1182
V VS+ +L+ L +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVL
Sbjct: 1280 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1339
Query: 1183 LVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES--GNFSWINQKVN 1239
LVCLIFWL+F I+GV F+GKF C+N T ++ + + + N S C++ W N KVN
Sbjct: 1340 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1399
Query: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299
FDNVG YLALLQVATFKGWMDI+YAAVDS + + QP +E N Y+YFV+FIIFGSFFT
Sbjct: 1400 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1459
Query: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
LNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V
Sbjct: 1460 LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMV 1519
Query: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
FD VT Q+FDI I+ LI LNM++MM E+ +Q K M +L +N VF+V+FT E ++K+ +
Sbjct: 1520 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS 1579
Query: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
LR YYFT GWN+FD VVV+LSIV ++ + + + PTLFR++RLARIGRILRL++
Sbjct: 1580 LRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV--SPTLFRVIRLARIGRILRLIKG 1637
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V E+GIDD+FNF+TF +
Sbjct: 1638 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1697
Query: 1540 SMLCLFQISTSAGWDSLLSPMLRS-KESC--------NSSSENCHLPGIATSYFVSYIII 1590
SM+CLFQI+TSAGWD LL+P+L S C +S +C P + +FVSYIII
Sbjct: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
Query: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650
SFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQFI++S LSDFA
Sbjct: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1817
Query: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710
AL PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG S +D+++ ME++
Sbjct: 1818 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1877
Query: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
FM +NP K YEPI TT KRK+EE AAIIQ+ FR Y++K
Sbjct: 1878 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLK 1917
Score = 409 bits (1052), Expect = e-113
Identities = 239/543 (44%), Positives = 318/543 (58%), Gaps = 54/543 (9%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-QPRPQLDLKASRKLPKLYGDI 69
P +FR FT +SLAAIEKR A +K KK K+Q + +P+P DL+A + LP +YGDI
Sbjct: 9 PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P E++ +PLEDLDP+Y N KTF+V+N+ + I+RFSA AL+I P N +R +AI++ VHS
Sbjct: 69 PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LFSM I+ T++ NCVFM + N E FTGIY FE+LIKILARGF L++F+
Sbjct: 129 LFSMLIMCTILTNCVFMTLSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFT 184
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A V+ + + LRTFRV RALK ISV+ LK IVGAL++S
Sbjct: 185 FLRDPWNWLDFSVIVMAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCIS---RDCKNISNPEAY--------- 297
VKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ D +N +Y
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 298 ------------------DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339
D F + + +CG C Y C NP+Y Y
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 340 TNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVV 399
T+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYL+NL LAVV
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 400 TMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAM--------------GIDRSSL 445
MAYEEQN+ E E KE FQ+ + LK+++E A+ G+
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
Query: 446 TSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 505
+S E S + K K + N+++K R + + + D K + + KR S
Sbjct: 484 SSSEASKLSSKSAKEWRNRRKK----RRQREHLEGNNKGERDSFPKSESEDSVKRSSFLF 539
Query: 506 SLD 508
S+D
Sbjct: 540 SMD 542
Score = 100 bits (250), Expect = 1e-20
Identities = 78/338 (23%), Positives = 151/338 (44%), Gaps = 50/338 (14%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R + H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A GF ++ + W WLD +++ +++VS + + LRT R
Sbjct: 1254 EMLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287
R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G
Sbjct: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1363
Query: 288 CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347
C N++ +D N + + G Q K+ K+ NFDN G
Sbjct: 1364 CVNMTTGNMFD--ISDVNNLSDCQALG---------KQARWKNVKV-------NFDNVGA 1405
Query: 348 SFLAMFRLMTQDSWEKLYQ----------QTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+LA+ ++ T W + Q + LY +F++ I GSF+ +NL +
Sbjct: 1406 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIG 1465
Query: 398 VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
V+ + +Q K + + ++K + A + L +K
Sbjct: 1466 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1503
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 88/338 (26%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+RK +I+ HS F I+ IL + +F + L N P + + T FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNC---VF--MTLSNPPDWTKNVEYT---FTGIYTFE 168
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +IV+ VT ++L + + RT R LR L+ +S
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTIS 228
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+
Sbjct: 229 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFE 288
Query: 1209 -------NGT----DSVINYTIIT-----------------------------NKSQCES 1228
NGT + +N T+ T + QC
Sbjct: 289 TNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPE 348
Query: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278
G N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 349 GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM--- 401
Query: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 402 -------IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 59/275 (21%)
Query: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA P S+ + VFTGI+ E ++KI+A +D + + ++ WN
Sbjct: 770 IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWN 825
Query: 197 WLDSIVIGIAIV----SYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK 252
D I++ ++++ S + G+++ LR+FR+ R K L +++ + SV
Sbjct: 826 IFDGIIVSLSLMELGLSNVEGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 881
Query: 253 LVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKM 312
L N+ ++ + IFA+VG QLF ++Y C
Sbjct: 882 LGNLTLVLAIIVFIFAVVGMQLF------------------GKSYKEC------------ 911
Query: 313 CGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C I +C + + ++F SFL +FR++ + E ++
Sbjct: 912 --------VCKINDDCTLPR-------WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 956
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
+ F++V+ +G+ ++NL LA++ ++ N
Sbjct: 957 QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDN 991
Score = 59.3 bits (142), Expect = 3e-08
Identities = 44/174 (25%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
PLN + + I+ +F ++I+ I+ N + M N P K++ + F I+T
Sbjct: 113 PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPPDWTKNV----EYTFTGIYT 166
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E LIKI F L + F + WN D V++++ V+ + L N +
Sbjct: 167 FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD-LGN----------VSAL 215
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 216 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 58.5 bits (140), Expect = 6e-08
Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 21/166 (12%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
V+K+ ++ + I I+ N VF+ + + + N+ FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESL 170
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677
+KI+A L+ + + R WN D V +++ F D+ N LR+FRVLR
Sbjct: 171 IKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-------LRTFRVLRA 223
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
K P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 42.4 bits (98), Expect = 0.004
Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + +F + I+ + +N V M ++ VF ++
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1570
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ L + F WN D +V+ ++IV I+ +R
Sbjct: 1571 GEFVLKLVS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1625
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G F
Sbjct: 1626 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------- 1677
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ KKE + + NF+
Sbjct: 1678 ----------------AYVKKEAGID----------------------------DMFNFE 1693
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1694 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVS 1753
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ K
Sbjct: 1754 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1813
Query: 434 ALVAMGID 441
+ A +D
Sbjct: 1814 SDFAAALD 1821
Score = 35.4 bits (80), Expect = 0.50
Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 28/136 (20%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 358 NPNYGYT---SFDTFSWAFLSLFRLMTQDYWENLYQLTLRA---------------AGKT 399
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL +VN+ +AV+ E N AT EE+E E +F E +K
Sbjct: 400 YMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 457
Query: 1636 EATQFIKYSALS-DFA 1650
EA SA S DF+
Sbjct: 458 EAQAVAAASAASRDFS 473
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 1281 bits (3315), Expect = 0.0
Identities = 691/1301 (53%), Positives = 899/1301 (69%), Gaps = 95/1301 (7%)
Query: 505 LSLDHFDEHGDPLQRQRALSAVSILTITMKEQ-EKSQEPCLPCGENLASKYLVWNCCPQW 563
+S+D +G ++ R S +S++T T+ E+ E+SQ C PC A+ +L+W C P W
Sbjct: 683 VSMDQLASYG---RKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYW 739
Query: 564 LCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAE 623
+ +K+++ ++ DPF +LAITICI++NT+F+AMEHH M FE +L +GNLVFT IF AE
Sbjct: 740 IKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAE 799
Query: 624 MCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKS 683
M LK+IA+DPY+YF+ GWNIFD + LS ++ ++ S LRSFR+LRVFKLAKS
Sbjct: 800 MFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLS--VLRSFRLLRVFKLAKS 857
Query: 684 WPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ--KSPKLCNPTGP 741
WPTLN LIKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+ K + C
Sbjct: 858 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCE---- 913
Query: 742 TVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLV 801
L WHM DF+HSFL+VFR+LCGEWIE MW+CM+ A ++C+IVF+++ VIG LV
Sbjct: 914 ----LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVFMMVMVIGNLV 967
Query: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQ 861
VLNLF+ALLL+SFS + + + +Q+++ R ++ + + + F +++
Sbjct: 968 VLNLFLALLLSSFSADNLAAT-DDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQR 1026
Query: 862 NLPQQK------EVAGGCAAQ--SKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDW 913
+ K E C A DI K G+ T +G +SV K +
Sbjct: 1027 EADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIG--SSVEKYI------ 1078
Query: 914 TWLAPLAEEEDDVEFSGEDNAQ-RITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSED 972
+ED + F N R+ E L+ E D+ SE
Sbjct: 1079 -------IDEDHMSFINNPNLTVRVPIAVGESDFENLNTE--------------DVSSES 1117
Query: 973 EPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKK--QPERCLPKGFGCCFPCC 1030
+P + + K D TS SE STID++ +P P++ P+ C +G F CC
Sbjct: 1118 DP----EGSKDKLDDTSS-SEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
Query: 1031 SVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELL 1090
V+ + WW LRKTC+ IV+H+WFE+FIIF+ILLSSGAL FED+++E + I+ +L
Sbjct: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
Query: 1091 NCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMEL 1143
D +FT+IFILEM+LKW A+GF K+FT+AWC LDF+IV VS+ +LI L +
Sbjct: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
Query: 1144 KSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGK 1203
KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GK
Sbjct: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
Query: 1204 FGKCINGTDSVINYTI--ITNKSQCES---GN---FSWINQKVNFDNVGNAYLALLQVAT 1255
+ C N T S I + I + NK++CE GN W N K+NFDNVG YLALLQVAT
Sbjct: 1353 YHYCFNET-SEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT 1411
Query: 1256 FKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
FKGWMDI+YAAVDS + ++QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+
Sbjct: 1412 FKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1471
Query: 1316 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISL 1375
KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG+VFD VT Q FDI+I+ L
Sbjct: 1472 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMML 1531
Query: 1376 IILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCV 1435
I LNM++MM E+ Q K M++IL +N VFV+ FT EC++K+FALR YYFT GWN+FD V
Sbjct: 1532 ICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFV 1591
Query: 1436 VVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLP 1495
VV+LSIV ++ + + + PTLFR++RLARIGRILRL++ A+GIRTLLFALMMSLP
Sbjct: 1592 VVILSIVGMFLADIIEKYFV--SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1649
Query: 1496 SLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDS 1555
+LFNIGLLLFL+MFI++I GM+ F+ V E+GIDD+FNF+TF +SM+CLFQI+TSAGWD
Sbjct: 1650 ALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDG 1709
Query: 1556 LLSPMLRSKESCNSSSE--------NCHLPGIATSYFVSYIIISFLIVVNMYIAVILENF 1607
LL P+L C+ E +C P + +FVSYIIISFLIVVNMYIA+ILENF
Sbjct: 1710 LLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769
Query: 1608 NTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQF 1667
+ ATEES DPL EDDF+ FYE+WEKFDP+ATQFI+Y L+DFADAL PLRV KPN +
Sbjct: 1770 SVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIEL 1829
Query: 1668 LVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTT 1727
+ MDLPMVS DR+HC+DILFAFT RVLG S LD ++ MEE+F+ +NP K YEPI TT
Sbjct: 1830 IAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTT 1889
Query: 1728 TKRKEEERGAAIIQKAFRKYMMKVTKG---DQGDQNDLENG 1765
+RK+EE A ++Q+A+R ++ + +G + N LENG
Sbjct: 1890 LRRKQEEVSAVVLQRAYRGHLAR--RGFICKKTTSNKLENG 1928
Score = 399 bits (1026), Expect = e-110
Identities = 223/457 (48%), Positives = 291/457 (63%), Gaps = 23/457 (5%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKD-----QTGEVPQPRPQLDLKASRKLPKL 65
P +F+PFT +SLA IE+RIA K KK K + E +P+P DL+A + LP +
Sbjct: 9 PGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFI 68
Query: 66 YGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRV 125
YGDIP+ L+ PLED DP+Y KTF+VLNR +T++RFSA AL+I PFN IR +AI++
Sbjct: 69 YGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKI 128
Query: 126 SVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFIL 185
+HS+FSM I+ T++ NCVFM + + N E FTGIY FE+L+KI+ARGF +
Sbjct: 129 LIHSVFSMIIMCTILTNCVFMTFSNPPDWSKN----VEYTFTGIYTFESLVKIIARGFCI 184
Query: 186 DEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGA 245
D F+FLRDPWNWLD VI +A ++ + + LRTFRV RALK ISV+ LK IVGA
Sbjct: 185 DGFTFLRDPWNWLDFSVIMMAYITEFVNLG-NVSALRTFRVLRALKTISVIPGLKTIVGA 243
Query: 246 LLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-NISNPEAYDHCFEKK 304
L++SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S E F+ +
Sbjct: 244 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWE 303
Query: 305 E---NSPEFK---------MCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAM 352
E N F +CG C Y+C NP+Y YT+FD F W+FLA+
Sbjct: 304 EYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLAL 363
Query: 353 FRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAA 412
FRLMTQD WE LYQ TLR G + FF++VIF+GSFYL+NL LAVV MAYEEQN+
Sbjct: 364 FRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLE 423
Query: 413 EIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLE 449
E E KE F+ + LK+++E A + S+ T E
Sbjct: 424 EAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSE 460
Score = 105 bits (263), Expect = 3e-22
Identities = 81/337 (24%), Positives = 151/337 (44%), Gaps = 46/337 (13%)
Query: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIFE 173
+R + H+ F FII ++++ +A + + + A+ VFT I+I E
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
Query: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
L+K A GF+ F + W WLD +++ +++VS I + LRT R R
Sbjct: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
Query: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G
Sbjct: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK---------- 1352
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
Y +CF + + F++ + + C E +T+I NFDN G
Sbjct: 1353 --------YHYCF-NETSEIRFEIEDV-NNKTECEKLMEGNNTEIRWKNVKINFDNVGAG 1402
Query: 349 FLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
+LA+ ++ T W K +Q +Y +F++ I GSF+ +NL + V
Sbjct: 1403 YLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGV 1462
Query: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ + +Q K + + ++K + A + L +K
Sbjct: 1463 IIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1499
Score = 87.0 bits (214), Expect = 1e-16
Identities = 79/321 (24%), Positives = 141/321 (43%), Gaps = 71/321 (22%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + + F N P + + T FT I+ E
Sbjct: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFS-----NPPDWSKNVEYT---FTGIYTFE 172
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +++++ +T +NL + + RT R LR L+ +S
Sbjct: 173 SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTIS 232
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+
Sbjct: 233 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESY 292
Query: 1209 --NGT-----DSVIN-----YTI-----------ITNKSQCESG----------NFSWIN 1235
NGT + IN YT+ ++ QC G N+ +
Sbjct: 293 LENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGY-- 350
Query: 1236 QKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFG 1295
+FD A+LAL ++ T W ++ + + K I+FV+ I G
Sbjct: 351 --TSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM----------IFFVLVIFVG 398
Query: 1296 SFFTLNLFIGVIIDNFNQQQK 1316
SF+ +NL + V+ + +Q +
Sbjct: 399 SFYLVNLILAVVAMAYEEQNQ 419
Score = 68.6 bits (166), Expect = 5e-11
Identities = 57/271 (21%), Positives = 114/271 (42%), Gaps = 51/271 (18%)
Query: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
+++N +FMA P + + VFTGI+ E +K++A +D + + ++ WN
Sbjct: 763 IVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWN 818
Query: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
D ++ ++++ L LR+FR+ R K L +++ + SV L N+
Sbjct: 819 IFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 878
Query: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
++ + IFA+VG QLF ++Y C
Sbjct: 879 TLVLAIIVFIFAVVGMQLF------------------GKSYKEC---------------- 904
Query: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
C I +C+ + + +F SFL +FR++ + E ++
Sbjct: 905 ----VCKINQDCELPR-------WHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 953
Query: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
+ F++V+ +G+ ++NL LA++ ++ N
Sbjct: 954 LIVFMMVMVIGNLVVLNLFLALLLSSFSADN 984
Score = 67.8 bits (164), Expect = 9e-11
Identities = 62/332 (18%), Positives = 134/332 (40%), Gaps = 67/332 (20%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++++ ++ + I I+ N VF+ + + K + FT I+ E
Sbjct: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSN---PPDWSKNVEY---TFTGIYTFESL 174
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KIIA +D + + R WN D V ++++ + + LR+FRVLR K
Sbjct: 175 VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEF---VNLGNVSALRTFRVLRALKTI 231
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ----------- 730
P L T++ + SV L + ++ V + +F+++G+QLF + ++
Sbjct: 232 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291
Query: 731 ---------------------------KSPKLCNPTGPTVSCLRHWH------------- 750
P LC + C +
Sbjct: 292 YLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYT 351
Query: 751 -MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIAL 809
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A+
Sbjct: 352 SFDTFSWAFLALFRLMTQDYWENLYQL--TLRAAGKTYMIFFVLVIFVGSFYLVNLILAV 409
Query: 810 LLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+ ++ + + E E ++ + + L++ ++
Sbjct: 410 VAMAYEEQNQATLEEAEQKEAEFKAMLEQLKK 441
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/185 (23%), Positives = 87/185 (47%), Gaps = 24/185 (12%)
Query: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
S P I P N + + I+ +F +II+ I+ N + M N P K++
Sbjct: 107 SATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNV--- 161
Query: 1401 LNWVFVVIFTLECLIKIFALRQY------YFTNGWNLFDCVVVLLSIVSTMISTLENQEH 1454
+ F I+T E L+KI A R + + + WN D V++++ ++ ++ L N
Sbjct: 162 -EYTFTGIYTFESLVKIIA-RGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN-LGN--- 215
Query: 1455 IPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAIL 1514
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++
Sbjct: 216 -------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALI 268
Query: 1515 GMNWF 1519
G+ F
Sbjct: 269 GLQLF 273
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 1278 bits (3307), Expect = 0.0
Identities = 683/1306 (52%), Positives = 908/1306 (69%), Gaps = 75/1306 (5%)
Query: 475 GKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMK 534
G+ P G+ ++ + +K+ + S ++S+D + DP QRQRA+S SILT T++
Sbjct: 665 GQLLPEGTTTETEMRKR-------RSSSFHVSMDFLE---DPSQRQRAMSIASILTNTVE 714
Query: 535 EQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFL 594
E E+S++ C PC ++ +L+W+C P WL VK V+ V+ DPF +LAITICI++NT+F+
Sbjct: 715 ELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFM 774
Query: 595 AMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFA 654
AMEH+ M F +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD + LS
Sbjct: 775 AMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLV 834
Query: 655 DVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFI 714
++ ++ S LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++FI
Sbjct: 835 ELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 892
Query: 715 FSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMW 774
F+VVGMQLFG+S+ K C + L WHM DF+HSFL+VFR+LCGEWIE MW
Sbjct: 893 FAVVGMQLFGKSY------KDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMW 946
Query: 775 ECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL 834
+CM+ A ++C+ VF+++ VIG LVVLNLF+ALLL+SFS + + + +Q+
Sbjct: 947 DCMEVAG--QAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAAT-DDDNEMNNLQI 1003
Query: 835 ALDRFRRAFCFVRHTLEHFCHK-WCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSET 893
A+DR + +V+ + F + + RKQ + + + + + +E
Sbjct: 1004 AVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMS-----NHTAEI 1058
Query: 894 QEELGILTSVPKTL-GVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEP--EQQAYELH 950
++L L V T G+ + + +E D + F + +T P E L+
Sbjct: 1059 GKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLT-VTVPIAVGESDFENLN 1117
Query: 951 QENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMV 1010
E D SE + +++ ++K + +S SE ST+D+ P +
Sbjct: 1118 TE--------------DFSSESD----LEESKEKLNESSSSSEGSTVDIGAPVEEQPVVE 1159
Query: 1011 PKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILL 1068
P++ +PE C +G F CC ++ + WWNLR+TC++IV+H+WFE+FI+F+ILL
Sbjct: 1160 PEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILL 1219
Query: 1069 SSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFI 1128
SSGAL FED++++ + I+ +L D +FT+IFILEM+LKWVA+G+ YFT+AWC LDF+
Sbjct: 1220 SSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFL 1279
Query: 1129 IVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNV 1181
IV VS+ +L L +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NV
Sbjct: 1280 IVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1339
Query: 1182 LLVCLIFWLVFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQC-----ESGNFSWIN 1235
LLVCLIFWL+F I+GV F+GKF CIN T + + N + C + W N
Sbjct: 1340 LLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKN 1399
Query: 1236 QKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFG 1295
KVNFDNVG YL+LLQVATFKGWMDI+YAAVDS E QP++E + Y+YFV+FIIFG
Sbjct: 1400 VKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFG 1459
Query: 1296 SFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKC 1355
SFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK
Sbjct: 1460 SFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKF 1519
Query: 1356 QGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLI 1415
QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + + +IL +N VF+V+FT EC++
Sbjct: 1520 QGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVL 1579
Query: 1416 KIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILR 1475
K+ +LR YYFT GWN+FD VVV+LSIV ++ L + + PTLFR++RLARIGRILR
Sbjct: 1580 KLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRVIRLARIGRILR 1637
Query: 1476 LVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFK 1535
L++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V E GIDD+FNF+
Sbjct: 1638 LIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFE 1697
Query: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSK-ESCNSSSEN--------CHLPGIATSYFVS 1586
TF +SM+CLFQI+TSAGWD LL+P+L SK C+ + N C P + +FVS
Sbjct: 1698 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVS 1757
Query: 1587 YIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSAL 1646
YIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQF+++ L
Sbjct: 1758 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKL 1817
Query: 1647 SDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAM 1706
S FA AL PL + +PNK Q + MDLPMVS DR+HC+DILFAFT RVLG S +D+++
Sbjct: 1818 SQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQ 1877
Query: 1707 MEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVT 1752
MEE+FM +NP K Y+PI TT KRK+EE A IIQ+A+R++++K T
Sbjct: 1878 MEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRT 1923
Score = 413 bits (1061), Expect = e-115
Identities = 248/548 (45%), Positives = 318/548 (58%), Gaps = 69/548 (12%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKL 65
PD NF FT +SLAAIE+RIA +K K KK D+ G P+P DL+A + LP +
Sbjct: 11 PDSFNF--FTRESLAAIERRIAEEKAKNPKPDKKDDDENG----PKPNSDLEAGKNLPFI 64
Query: 66 YGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRV 125
YGDIP E++ +PLEDLDP+Y N KTF+VLN+ + I+RFSA AL+I PFN +R +AI++
Sbjct: 65 YGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKI 124
Query: 126 SVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFIL 185
VHSLFSM I+ T++ NCVFM + N E FTGIY FE+LIKI+ARGF L
Sbjct: 125 LVHSLFSMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKIIARGFCL 180
Query: 186 DEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGA 245
++F+FLRDPWNWLD VI A V+ + + LRTFRV RALK ISV+ LK IVGA
Sbjct: 181 EDFTFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGA 239
Query: 246 LLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKK- 304
L++SVKKL +V+ILT FCLS+FAL+G QLFMG+L KCI N S E H EK
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEE---HSIEKNI 296
Query: 305 -------------------------------ENSPEFKMCGIWMGNSACSIQYECKHTKI 333
E + +CG C Y C
Sbjct: 297 TVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGR 356
Query: 334 NPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLIN 393
NP+Y YT+FD F W+FL++FRLMTQD WE LYQ TLR G + FF++VIFLGSFYLIN
Sbjct: 357 NPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLIN 416
Query: 394 LTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEAL-------------VAMGI 440
L LAVV MAYEEQN+ E E KE FQ+ + LK+++EA
Sbjct: 417 LILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAA 476
Query: 441 DRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKR 500
R S +S E S + K K N+++K K+Q G + DED +K + + +R
Sbjct: 477 GRLSDSSSEASKLSSKSAKERRNRRKK-----RKQKEQSGGEEKDEDEFQKSESEDSIRR 531
Query: 501 LSQNLSLD 508
S++
Sbjct: 532 KGFRFSIE 539
Score = 100 bits (248), Expect = 2e-20
Identities = 79/341 (23%), Positives = 154/341 (45%), Gaps = 53/341 (15%)
Query: 117 SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172
++R R+ H+ F FI+ ++++ +A + + + A+ VFT I+I
Sbjct: 1195 NLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFIL 1254
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227
E L+K +A G+ ++ + W WLD +++ +++VS + LRT R
Sbjct: 1255 EMLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310
Query: 228 RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISR- 286
R L+A+S ++V+V ALL ++ ++NV+++ IF+++G LF G CI+
Sbjct: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YHCINTT 1369
Query: 287 --DCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDN 344
D +I + + C + E + + W K+ K+ NFDN
Sbjct: 1370 TGDRFDIEDVNNHTDCLKLIERNETAR----W------------KNVKV-------NFDN 1406
Query: 345 FGWSFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINL 394
G+ +L++ ++ T W + Q LY +F++ I GSF+ +NL
Sbjct: 1407 VGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNL 1466
Query: 395 TLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
+ V+ + +Q K + + ++K + A + L +K
Sbjct: 1467 FIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507
Score = 80.5 bits (197), Expect = 1e-14
Identities = 79/337 (23%), Positives = 138/337 (40%), Gaps = 87/337 (25%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
LRK +I+ HS F I+ IL + +F + + N P + + T FT I+ E
Sbjct: 117 LRKIAIKILVHSLFSMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 168
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF +I VT ++L + + RT R LR L+ +S
Sbjct: 169 SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 228
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
G+K +V ALI ++ + +V+++ + VF ++G+ F G KCI
Sbjct: 229 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLE 288
Query: 1209 ----------NGTDSVINYTII-----------------------------TNKSQCESG 1229
N ++IN T+ ++ QC G
Sbjct: 289 EHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEG 348
Query: 1230 ----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFE 1279
N+ + +FD A+L+L ++ T W ++ + + K
Sbjct: 349 YMCVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM---- 400
Query: 1280 SNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 401 ------IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431
Score = 72.8 bits (177), Expect = 3e-12
Identities = 67/310 (21%), Positives = 132/310 (42%), Gaps = 52/310 (16%)
Query: 101 YRFSAKHALFIFGPF-NSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSN 157
Y+FS ++ P+ ++ + V + + I +++N +FMA P + +N
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 158 NTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK 217
+ VFTGI+ E +KI+A +D + + ++ WN D ++ +++V
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 218 LLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
L LR+FR+ R K L +++ + SV L N+ ++ + IFA+VG QLF
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 903
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
S +DC C I +C+ +
Sbjct: 904 SY------KDC--------------------------------VCKIASDCQLPR----- 920
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397
+ ++F SFL +FR++ + E ++ + F++V+ +G+ ++NL LA
Sbjct: 921 --WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLA 978
Query: 398 VVTMAYEEQN 407
++ ++ N
Sbjct: 979 LLLSSFSADN 988
Score = 59.3 bits (142), Expect = 3e-08
Identities = 46/162 (28%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
++K+ ++ + I I+ N VF+ M + + N+ FT I+ E
Sbjct: 117 LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 170
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
+KIIA L+ + + R WN D V ++FA V V + LR+FRVLR K
Sbjct: 171 IKIIARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 227
Query: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P L T++ + SV L + ++ V + +F+++G+QLF
Sbjct: 228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 57.0 bits (136), Expect = 2e-07
Identities = 43/174 (24%), Positives = 81/174 (46%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P N + + I+ +F ++I+ I+ N + M N P K++ + F I+T
Sbjct: 113 PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMS--NPPDWTKNV----EYTFTGIYT 166
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E LIKI F L + F + WN D V+ + V+ + L N +
Sbjct: 167 FESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN----------VSAL 215
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 216 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 46.2 bits (108), Expect = 3e-04
Identities = 69/368 (18%), Positives = 134/368 (36%), Gaps = 97/368 (26%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + +F + I+ + +N V M S T ++ VF ++
Sbjct: 1515 PGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFT 1574
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223
E ++K+++ L + F WN D +V+ ++IV I+ +R
Sbjct: 1575 GECVLKLIS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1629
Query: 224 FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283
R+ R L+ I ++ ++ AL+ S+ L N+ +L F + I+A+ G N
Sbjct: 1630 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1683
Query: 284 ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343
+ R+ D F NF+
Sbjct: 1684 VKREV-------GIDDMF---------------------------------------NFE 1697
Query: 344 NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382
FG S + +F++ T W+ L L + +FFF+
Sbjct: 1698 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVS 1757
Query: 383 VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433
I + ++N+ +AV+ ++A EE + ++ + E EK +A Q ++ EK
Sbjct: 1758 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKL 1817
Query: 434 ALVAMGID 441
+ A ++
Sbjct: 1818 SQFAAALE 1825
Score = 32.3 bits (72), Expect = 4.2
Identities = 33/124 (26%), Positives = 55/124 (44%), Gaps = 27/124 (21%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP G +F TF+ + L LF++ T W++L LR+ +
Sbjct: 357 NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 398
Query: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635
Y + ++++ FL ++N+ +AV+ E N AT EE+E E +F E +K
Sbjct: 399 YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMIEQLKKQQE 456
Query: 1636 EATQ 1639
A Q
Sbjct: 457 AAQQ 460
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 1163 bits (3009), Expect = 0.0
Identities = 696/1780 (39%), Positives = 1003/1780 (56%), Gaps = 182/1780 (10%)
Query: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASRKLPKLYGDIP 70
P+ + PFT +S I++ IA K ++D E +P P DL+ +KLP +YG++
Sbjct: 5 PEPKGLVPFTKESFELIKQHIA----KTHNEDHEEEDLKPTP--DLEVGKKLPFIYGNLS 58
Query: 71 RELIGKPLEDLDPFYRNHK-TFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
+ ++ +PLED+DP+Y K TF+VLN+ RTI+RF+A L PFN IR I+V VH
Sbjct: 59 QGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHP 118
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
F +FI+ +V+I+CVFM+ + + E GIY FE L+K+ ARG FS
Sbjct: 119 FFQLFILISVLIDCVFMSL----TNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFS 174
Query: 190 FLRDPWNWLD-SIVIGIAIVSYIPGITIKLLP-LRTFRVFRALKAISVVSRLKVIVGALL 247
FL DPWNWLD S+ + I+ Y P + +P L+T R R LK I + LK +VG L+
Sbjct: 175 FLGDPWNWLDFSVTVFEVIIRYSP---LDFIPTLQTARTLRILKIIPLNQGLKSLVGVLI 231
Query: 248 RSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCI----SRDCKNISNPEAYDHCFEK 303
+K+L+ VIILT F LSIF+L+G LFMG+L KC + + + N + +
Sbjct: 232 HCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRE 291
Query: 304 KENSPEFK------MCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMT 357
EN + +CG C Y C INPD +TNFD+FGW+ A+FRLM
Sbjct: 292 TENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMA 351
Query: 358 QDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAK 417
QD E LY Q L +G + FF+VV FL SFY+ +L L ++ MAYEE+ + V +
Sbjct: 352 QDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKI 411
Query: 418 EKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKD 477
E FQ ++GK+
Sbjct: 412 EPKFQ--------------------------------------------------QTGKE 421
Query: 478 QPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQ- 536
G+++DE K +E KR P+ +L + T+ KE+
Sbjct: 422 LQEGNETDE---AKTIQIEMKKR--------------SPISTDTSLDVLEDATLRHKEEL 464
Query: 537 EKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM 596
EKS++ C A +L+WNC P WL +K+ + ++ PFT+L + ICII+N FL +
Sbjct: 465 EKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTL 524
Query: 597 EHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADV 656
EH+ M +LNIGNLVF IF AEM KIIA+ PY YF+ GWNIFDS++ ++
Sbjct: 525 EHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIEL 584
Query: 657 MNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFS 716
C+ LR FR+LR+FKL K WPT L+ + NS AL L ++L IF +
Sbjct: 585 --CLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSA 642
Query: 717 VVGMQLFGRSFNSQKS--PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMW 774
GM+LFG+++ K C L WHM DF+HSFL VFRILCGEW+E +W
Sbjct: 643 AFGMKLFGKNYEEFVCHIDKDCQ--------LPRWHMHDFFHSFLNVFRILCGEWVETLW 694
Query: 775 ECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL 834
+CM+ A S C+ ++++ +IG L+VL LF+AL+ + S ++ EA+ +QL
Sbjct: 695 DCMEVAG--QSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKN--LQL 750
Query: 835 ALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQ 894
A+ R ++ +V + C+ QN+P KD + V E+ +
Sbjct: 751 AVARIKKGINYVLLKI------LCKTQNVP-------------KDTMDHVNEVY----VK 787
Query: 895 EELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENK 954
E++ T L+ L+ +D ++ + + E+ A E ++
Sbjct: 788 EDISDHT--------------LSELSNTQDFLKDKEKSSGT-------EKNATENESQSL 826
Query: 955 KPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSD--------VTSILSECSTIDLQDGFGWL 1006
P+ ++V I D +L ++ + KS S SECST+D+
Sbjct: 827 IPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDI--AISEE 884
Query: 1007 PEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVI 1066
EM + + L G + IW N+RKTC +IV+++WF+ FI V
Sbjct: 885 EEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVT 944
Query: 1067 LLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLD 1126
LLS+G L FED++++ + I+ LL D+IFT+IFILEM+LKW+A+GF YF++ W LD
Sbjct: 945 LLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLD 1004
Query: 1127 FIIVIVSVTTLINLM--ELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLV 1184
F++VIV +LI ELK +++ LRPLR LSQFE MKVVV ALI LNV LV
Sbjct: 1005 FVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLV 1064
Query: 1185 CLIFWLVFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQCESGNFS----WINQKVN 1239
CL+ WL+F I+GV F+G+F +CI+ T + + NKS+CES F+ W N K+N
Sbjct: 1065 CLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMN 1124
Query: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299
FDNVGN +L+LLQVATF GW+ I+ +A+DS QP FE N Y YF+ FIIFG F
Sbjct: 1125 FDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLP 1184
Query: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
L++ I VIIDNFN+ + KLGG +IF+T +Q+K Y +KKL + Q+P+PRPLNK QG +
Sbjct: 1185 LSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFI 1244
Query: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
FD+VTSQ F++I++ LI I+MM ++ Q M L +N +FV+++T+EC++K+ A
Sbjct: 1245 FDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIA 1304
Query: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
R +YFT WN+FD +VV+ SI + + PP+L +++ L+RI +LRL +
Sbjct: 1305 FRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLV--PPSLVQLILLSRIIHMLRLGKG 1362
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
+ L+ LM+SLP+L NI LL+FL+MFIYA+ GM F+ V E+GI+D+ NF+TF +
Sbjct: 1363 PKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGN 1422
Query: 1540 SMLCLFQISTSAGWDSLLSPMLRSKES-CNSSSEN--------CHLPGIATSYFVSYIII 1590
SMLCLFQ++ AGWD +L + SK S C+ N C P + YFVSYI+I
Sbjct: 1423 SMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILI 1482
Query: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650
S+LI+VNMYI V++E N A+++ L EDDF F++VW++FDP+ TQ+I S LSDFA
Sbjct: 1483 SWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFA 1542
Query: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710
AL PL +AKPNK Q + +DLPM DR+HC+DIL AFT RV+G ++ + + +E
Sbjct: 1543 AALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESG 1602
Query: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
F+ ANP K EPI TT KRK+E A IIQ+A++ Y ++
Sbjct: 1603 FLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLR 1642
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 782 bits (2020), Expect = 0.0
Identities = 397/596 (66%), Positives = 477/596 (80%), Gaps = 23/596 (3%)
Query: 1075 FEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSV 1134
FED++LE + I+ LL D +FT++F+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+
Sbjct: 833 FEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSL 892
Query: 1135 TTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLI 1187
+L+ + +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLI
Sbjct: 893 VSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 952
Query: 1188 FWLVFCILGVYFFSGKFGKCINGT--DSVINYTIITNKSQCES----GNFSWINQKVNFD 1241
FWL+F I+GV F+GKFG+CIN T D +NYTI+ NKSQCES G W KVNFD
Sbjct: 953 FWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFD 1012
Query: 1242 NVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLN 1301
NVG YLALLQVATFKGWMDI+YAAVDS E+QP++E N YIYFV+FIIFGSFFTLN
Sbjct: 1013 NVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLN 1072
Query: 1302 LFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFD 1361
LFIGVIIDNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD
Sbjct: 1073 LFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1132
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IVT Q FD+ I+ LI LNM++MM E+ +Q +IL +N +FV IFT EC++K+ ALR
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
Query: 1422 QYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAAR 1481
YYFTN WN+FD VVV+LSIV T++S + + F PTLFR++RLARIGRILRL+R A+
Sbjct: 1193 HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAK 1250
Query: 1482 GIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSM 1541
GIRTLLFALMMSLP+LFNIGLLLFL+MFIY+I GM F+ V E+GIDD+FNF+TFA+SM
Sbjct: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1310
Query: 1542 LCLFQISTSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIATSYFVSYIIISFL 1593
LCLFQI+TSAGWD LLSP+L + + N S +C P + +F +YIIISFL
Sbjct: 1311 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1370
Query: 1594 IVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDF 1649
IVVNMYIA+ILENF+ ATEES +PL EDDFD+FYE+WEKFDPEATQFI+YS + F
Sbjct: 1371 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRF 1426
Score = 453 bits (1165), Expect = e-127
Identities = 256/516 (49%), Positives = 334/516 (64%), Gaps = 37/516 (7%)
Query: 15 NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69
+FR FT +SLAAIEKR+A ++ + ++S++ E PRPQLDL+AS+KLP LYG+
Sbjct: 12 SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
Query: 70 PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
P+ELIG+PLEDLDPFY KTF+VLN+ +TI+RFSA +AL++ PF+ IR A+++ VHS
Sbjct: 72 PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
Query: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
LF+M I+ T++ NCVFMA ++ T E FT IY FE+L+KILARGF L F+
Sbjct: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
Query: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249
FLRDPWNWLD VI +A + + + LRTFRV RALK ISV+S LK IVGAL++S
Sbjct: 188 FLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRALKTISVISGLKTIVGALIQS 246
Query: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-------------------- 289
VKKL +V++LT FCLS+FAL+G QLFMG+L KC+
Sbjct: 247 VKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDL 306
Query: 290 NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSF 349
+S+PE Y K + + +CG C Y C NPD+ YT+FD+F W+F
Sbjct: 307 YLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAF 362
Query: 350 LAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKN 409
LA+FRLMTQD WE+LYQQTLR+ G + FF++VIFLGSFYL+NL LAVV MAYEEQN+
Sbjct: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422
Query: 410 VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKRK 467
AE E KEK FQEA ++LK+E EAL G+D S +SLE S P + +KR
Sbjct: 423 TIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRM 482
Query: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503
S E G+D+ P SDS ED + L T+ LS+
Sbjct: 483 SSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
Score = 96.7 bits (239), Expect = 2e-19
Identities = 70/291 (24%), Positives = 138/291 (47%), Gaps = 43/291 (14%)
Query: 160 DIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI--- 216
+ A+ +FT +++ E L+K +A GF + + W WLD +++ +++VS +
Sbjct: 849 EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
Query: 217 --KLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQL 274
+ LRT R R L+A+S ++V+V AL+ ++ ++NV+++ IF+++G L
Sbjct: 905 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
Query: 275 FMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKIN 334
F G +CI++ ++ P Y K + C + ++ E TK+
Sbjct: 965 FAGKFG-RCINQTEGDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK 1008
Query: 335 PDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVI 384
NFDN G +LA+ ++ T W + + + G LY +F++ I
Sbjct: 1009 -----VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFI 1063
Query: 385 FLGSFYLINLTLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
GSF+ +NL + V+ + +Q K + + + ++K + A + L +K
Sbjct: 1064 IFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1114
Score = 85.9 bits (211), Expect = 3e-16
Identities = 81/343 (23%), Positives = 150/343 (43%), Gaps = 69/343 (20%)
Query: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
+R+ +I+ HS F I+ IL + +F H + P + + T FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
Query: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVSVTT-LINLMELKSFRTLRALRPLRALS 1159
++K +A GF + W LDF ++I++ TT ++L + + RT R LR L+ +S
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTIS 231
Query: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+ NGT+
Sbjct: 232 VISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
Query: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236
+ NY + S +C + +
Sbjct: 292 GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
Query: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
+FD+ A+LAL ++ T W + QQ + + I+F++ I GS
Sbjct: 352 YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
Query: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339
F+ +NL + V+ + +Q + + E++K++ AM+ L
Sbjct: 402 FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
Score = 74.3 bits (181), Expect = 1e-12
Identities = 65/257 (25%), Positives = 118/257 (45%), Gaps = 18/257 (7%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALD 632
++T ++ I I +N V + +E +L NL+F +IF E +K+ AL
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
Query: 633 PYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKRSWP-----FLRSFRVLRVFKLAKSWPT 686
Y YF WNIFD +V +LS V++ ++QK + +R R+ R+ +L +
Sbjct: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
Query: 687 LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN--PTGPTVS 744
+ TL+ + S+ AL ++ ++L +V+FI+S+ GM F + N ++
Sbjct: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSML 1311
Query: 745 CLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLC------VIVFILITVIG 798
CL W L + + + +N S C ++ F +I
Sbjct: 1312 CLFQITTSAGWDGLLSPILNTGPPYCD---PTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1368
Query: 799 KLVVLNLFIALLLNSFS 815
L+V+N++IA++L +FS
Sbjct: 1369 FLIVVNMYIAIILENFS 1385
Score = 62.4 bits (150), Expect = 4e-09
Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 78/339 (23%)
Query: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
+++ ++ + I I+ N VF+A + + FT+I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
Query: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677
+KI+A L + + R WN D V +++ F D+ N LR+FRVLR
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSA-------LRTFRVLRA 226
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF-- 727
K L T++ + SV L + V+ V + +F+++G+QLF R+F
Sbjct: 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA 286
Query: 728 -------------------------------NSQKSPKLCNPTGPTVSCLRHWH------ 750
N LC + +C +
Sbjct: 287 LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGE 346
Query: 751 --------MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVV 802
F +FL +FR++ + E +++ Q ++ + +I F+L+ +G +
Sbjct: 347 NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYL 404
Query: 803 LNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
+NL +A++ ++ + + E E ++ + Q A++ ++
Sbjct: 405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
Score = 61.6 bits (148), Expect = 7e-09
Identities = 51/241 (21%), Positives = 103/241 (42%), Gaps = 29/241 (12%)
Query: 608 MLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWP 667
+L + +FT +F+ EM LK +A YF W D ++ +S ++ L
Sbjct: 847 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
Query: 668 FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVIF--IFSVVGMQLFG 724
++S R LR + ++ + ++ VGA+ S + V+LV +IF IFS++G+ LF
Sbjct: 907 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
Query: 725 RSF------------------NSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILC 766
F N++ + N TG + + +L + ++
Sbjct: 967 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
Query: 767 GE-WIENMWECMQEANASSS-------LCVIVFILITVIGKLVVLNLFIALLLNSFSNEE 818
+ W++ M+ + I F++ + G LNLFI +++++F+ ++
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
Query: 819 R 819
+
Sbjct: 1087 K 1087
Score = 52.8 bits (125), Expect = 3e-06
Identities = 39/174 (22%), Positives = 83/174 (47%), Gaps = 22/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410
P + + I+ +F+++I+ I+ N + M ++ P K ++ + F I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
Query: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465
E L+KI F L + F + WN D V++++ + + L N +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGN----------VSAL 218
Query: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519
R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++G+ F
Sbjct: 219 RTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
Score = 40.8 bits (94), Expect = 0.012
Identities = 45/151 (29%), Positives = 61/151 (40%), Gaps = 11/151 (7%)
Query: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQ 861
VLNLF+ALLL+SFS + E + +QLAL R +R FV+ T FC C
Sbjct: 631 VLNLFLALLLSSFSADNLTAPDE-DREMNNLQLALARIQRGLRFVKRTTWDFC---CGLL 686
Query: 862 NLPQQKEVAGGCAAQSKDII-----PLVMEMKRGSETQEELGILTSVPKTLGVRHD-WTW 915
QK A Q I P E ++ T++E G D
Sbjct: 687 RQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPV 746
Query: 916 LAPLAEEEDDVEFSGEDNAQRI-TQPEPEQQ 945
P+A E D + ED + T+ E +Q
Sbjct: 747 CVPIAVAESDTDDQEEDEENSLGTEEESSKQ 777
Score = 33.9 bits (76), Expect = 1.5
Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)
Query: 114 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171
P N + + F + I+ + +N V M S +A+ +F I+
Sbjct: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
Query: 172 FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229
E ++K+ A + + WN D +V+ ++IV + I+ FRV R
Sbjct: 1182 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236
Query: 230 LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288
+ +G +LR ++ + L F +S+ AL L +
Sbjct: 1237 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1273
Query: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
F + I+ + Y I+ +N+ F N S
Sbjct: 1274 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1309
Query: 349 FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388
L +F++ T W+ L L T Y + FF I +
Sbjct: 1310 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1369
Query: 389 FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429
++N+ +A++ ++A EE + ++ + E EK EA Q ++
Sbjct: 1370 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1419
Score = 31.6 bits (70), Expect = 7.2
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP+ G +F +FA + L LF++ T W+ L LRS I
Sbjct: 347 NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
Query: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611
+F+ I + +VN+ +AV+ E N AT
Sbjct: 392 FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 354 bits (908), Expect = 5e-97
Identities = 196/594 (32%), Positives = 337/594 (56%), Gaps = 34/594 (5%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C I+ H F+ ++ I L+ + E +E + L ++ IFT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
LK V+ G FG+ Y S+W LD +V VS+ ++ + L+ R LR
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ G+K+VV LI ++ I N++L+C F+++F ILGV F GKF C+
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
++ ITN+S C + N+ W++ K NFDN+G A ++L +A+ GW++I+Y +D+
Sbjct: 1303 ---VDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE K
Sbjct: 1360 VDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--K 1417
Query: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
++K K + P + L+ + TS DI I +I LN+++M E YNQP
Sbjct: 1418 RLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQP 1477
Query: 1392 KAMKSILDHLNWVFVVIFTLECLIKI--FALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449
++++ L + N++F +F LE ++K+ F LR+ +F + WN D +VLLS++ + +
Sbjct: 1478 TSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKDRWNQLDLAIVLLSVMGITLEEI 1536
Query: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509
E +P PT+ RI+R+ RI R+L+L++ A G+R LL ++ +LP + N+GLL L+ F
Sbjct: 1537 EINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 1596
Query: 1510 IYAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK 1564
IYA LG+ F K+ NP G+ F+ F + L LFQ+ST W+ ++ LR
Sbjct: 1597 IYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR-- 1654
Query: 1565 ESCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
C +C L ++ YFVS+++ + +++N+ +AV++++ + + +E+++
Sbjct: 1655 -DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
Score = 211 bits (536), Expect = 7e-54
Identities = 203/803 (25%), Positives = 347/803 (43%), Gaps = 120/803 (14%)
Query: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKNSN--SNNTDIAEC 164
A F S R+ I++ + F + +++NCV + P + + S+ I +
Sbjct: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
Query: 165 VFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLP 220
I+IF E ++K++A G I + +L D WN LD ++ +V Y + I L
Sbjct: 118 FDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
Query: 221 LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLN 280
+RT RV R LKAI+ V ++++V LL ++ L NV++L FF IF ++G QL+ G L
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Query: 281 LKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNS---------------ACSIQ 325
+C + I A ++ +E+ +C + N C +
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
Query: 326 YE---------------------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQ 358
+ C+ NP NFDN G++++ +F+++T
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITL 356
Query: 359 DSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE------------- 405
+ W ++ + Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 357 EGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQR 416
Query: 406 ----QNKNVAAEIE---AKEKMFQEAQQLL-KEEKEALVAMGIDRSSLTSLETSYFTPKK 457
+ VA+ E E++FQ +L K ++ AL +S +L P K
Sbjct: 417 QRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAK 476
Query: 458 RKLFGNKKRK-SFFLRESGKDQPP-----------GSD--SDEDCQ----KKPQLLEQT- 498
+ R + S D P SD S CQ ++P L T
Sbjct: 477 PGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTD 536
Query: 499 ---KRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYL 555
+ S DE R A S L +E+E++ CG+
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGD------- 589
Query: 556 VWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLV 615
VW + LR ++ + I + I++NTV + +EHH+ +L I N+V
Sbjct: 590 VWR------ETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
Query: 616 FTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVL 675
FTS+F EM LK+ A + Y R +NIFDSI+ ++S +++ LR+FR+L
Sbjct: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG--QADGGLSVLRTFRLL 701
Query: 676 RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKL 735
RV KL + P L + ++ ++ + + ++L++ IFIFS++GM +FG F+ L
Sbjct: 702 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS------L 755
Query: 736 CNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILI 794
TG TV +++ + + VF+IL E W ++ M + +SL F+ +
Sbjct: 756 RTDTGDTVPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL---YFVAL 810
Query: 795 TVIGKLVVLNLFIALLLNSFSNE 817
G V+ NL +A+L+ F E
Sbjct: 811 MTFGNYVLFNLLVAILVEGFQAE 833
Score = 119 bits (299), Expect = 2e-26
Identities = 84/349 (24%), Positives = 165/349 (47%), Gaps = 55/349 (15%)
Query: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163
++++F P N R L + H LF ++ + +NC+ +A P + S ++
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
Query: 164 CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219
+FT I++ E +K+++ G E ++LR WN LD ++ ++I+ + + K+L
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
Query: 220 P-LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G C+ D +NI+N + + Y H K
Sbjct: 1294 KGKF-YHCLGVDTRNITN------------------------RSDCMAANYRWVHHKY-- 1326
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385
NFDN G + +++F L ++D W + QQ + + + +FI +
Sbjct: 1327 -----NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1381
Query: 386 LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA 434
+ SF+++N+ + VV + + ++ AE EA+ + + ++L K+ ++A
Sbjct: 1382 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLEKKRRKA 1429
Score = 105 bits (262), Expect = 4e-22
Identities = 69/281 (24%), Positives = 138/281 (49%), Gaps = 33/281 (11%)
Query: 569 VLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 628
++ ++ T + ++ IT I +N V +++EH+ S E L N +FT++F+ E LK+
Sbjct: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503
Query: 629 IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK----RSWP-------FLRSFRVLRV 677
+A +F+ WN D + LLS VM L++ + P +R R+ RV
Sbjct: 1504 VAFGLRRFFKDRWNQLDLAIVLLS---VMGITLEEIEINAALPINPTIIRIMRVLRIARV 1560
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN 737
KL K + L+ + ++ +G+L ++ +++ FI++ +G++LFG+ +CN
Sbjct: 1561 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK--------LVCN 1612
Query: 738 PTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV-------- 788
P RH +F +FL +F++ G+ W M + +++ C+
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
Query: 789 IVFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827
+ F+ + + V++N+ +A+L+ SN+E + E +A
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDA 1713
Score = 103 bits (258), Expect = 1e-21
Identities = 74/277 (26%), Positives = 137/277 (49%), Gaps = 28/277 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F+ I+ I++N +SM E + QP+ + +IL+ N VF +F LE ++K+ A
Sbjct: 601 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD ++V++SI E + ++R R+ R+L+LVR
Sbjct: 661 LFDYLRNPYNIFDSIIVIISI----------WEIVGQADGGLSVLRTFRLLRVLKLVRFM 710
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535
+R L LM ++ ++ +LL L +FI++ILGM+ F + + + D NF
Sbjct: 711 PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
Query: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595
+ +++ +FQI T W+ +L + S A+ YFV+ + ++
Sbjct: 771 SLLWAIVTVFQILTQEDWNVVLYNGMASTSPW------------ASLYFVALMTFGNYVL 818
Query: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEK 1632
N+ +A+++E F + + ED E ++K
Sbjct: 819 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
Score = 99.0 bits (245), Expect = 4e-20
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 40/279 (14%)
Query: 1041 IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHI 1100
+W R IV +F I+ IL+++ ++ E H E ++ +L +++FT +
Sbjct: 590 VWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSM 647
Query: 1101 FILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPL 1155
F LEM+LK AFG Y + + D IIVI+S+ ++ L L++FR LR L+ +
Sbjct: 648 FALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV 707
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVI 1215
R + VV L+ + + ++ ++F +F ILG++ F KF + D+V
Sbjct: 708 RFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTV- 763
Query: 1216 NYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQ 1275
+ NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 764 -------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----- 799
Query: 1276 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+ +YFV + FG++ NL + ++++ F +
Sbjct: 800 -----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 833
Score = 90.5 bits (223), Expect = 1e-17
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 14/168 (8%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVH-LENQPKIQELLNCTDIIFTHI 1100
R C ++V + WFE + VILL+ L +D+ L ++ KI ++ + D IF
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFD--DFIFI-F 125
Query: 1101 FILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTL---INLMELKSFRTLRALRP 1154
F +EMVLK VA G FGK Y W LDF IV+ + + + L + RT+R LRP
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
Query: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
L+A+++ M+++VN L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.7 bits (213), Expect = 2e-16
Identities = 71/327 (21%), Positives = 138/327 (42%), Gaps = 60/327 (18%)
Query: 131 FSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
F+ I+ +++N V M + +N +I VFT ++ E ++K+ A G F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
Query: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
+LR+P+N DSI++ I+I + L LRTFR+ R LK + + L+ + L++
Sbjct: 663 DYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMK 722
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSP 308
++ + +L + IF+++G +F CK + D ++K
Sbjct: 723 TMDNVATFCMLLMLFIFIFSILGMHIF-----------GCKFSLRTDTGDTVPDRK---- 767
Query: 309 EFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQT 368
NFD+ W+ + +F+++TQ+ W +
Sbjct: 768 --------------------------------NFDSLLWAIVTVFQILTQEDWNVVLYNG 795
Query: 369 LRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLL 428
+ +T ++ +F+ ++ G++ L NL +A++ ++ AE +A E Q
Sbjct: 796 MASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQ-------AEGDANRSYSDEDQSSS 848
Query: 429 KEEKEALVAMGIDRSSLTSLETSYFTP 455
E+ + G+D S L TP
Sbjct: 849 NIEEFDKLQEGLDSSGDPKLCPIPMTP 875
Score = 83.2 bits (204), Expect = 2e-15
Identities = 68/321 (21%), Positives = 142/321 (44%), Gaps = 37/321 (11%)
Query: 571 RTVMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKI 628
+T++ + + I +N + +A+E ++EA S E++ L + N +FT+IF+ EM LK+
Sbjct: 1129 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1188
Query: 629 IALDPYH----YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684
++L Y Y R WN+ D + +S D++ + L RVLR+ + +
Sbjct: 1189 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL 1248
Query: 685 ------PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSF------NSQKS 732
P L +++ + +S+ +G++ ++ IF ++G+QLF F +++
Sbjct: 1249 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI 1308
Query: 733 PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECM-------QEANAS 783
+ + H + D L+ +L + W+ M+ + Q
Sbjct: 1309 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH 1368
Query: 784 SSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRR- 841
+ ++ FI +I VLN+F+ +++ +F ++ E R+ + +L L++ RR
Sbjct: 1369 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK 1428
Query: 842 --------AFCFVRHTLEHFC 854
+C R + C
Sbjct: 1429 AQRLPYYATYCHTRLLIHSMC 1449
Score = 80.1 bits (196), Expect = 2e-14
Identities = 68/324 (20%), Positives = 136/324 (41%), Gaps = 87/324 (26%)
Query: 124 RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176
R+ +HS+ +FI + +N V M+ S T + C +FT +++ EA++
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1501
Query: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222
K++A G F +D WN LD ++ ++++ GIT++ LP+ R
Sbjct: 1502 KLVAFGLR----RFFKDRWNQLDLAIVLLSVM----GITLEEIEINAALPINPTIIRIMR 1553
Query: 223 TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
R+ R LK + + + ++ ++ +++++ ++ N+ +L I+A +G +LF
Sbjct: 1554 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1606
Query: 283 CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342
G C+ + C+ + F
Sbjct: 1607 -----------------------------------GKLVCNDENPCEGMS-----RHATF 1626
Query: 343 DNFGWSFLAMFRLMTQDSWEKLYQQTLR-----------TTGLYSVFFFIVVIFLGSFYL 391
+NFG +FL +F++ T D+W + + TLR + S +F+ + F L
Sbjct: 1627 ENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVL 1686
Query: 392 INLTLAVVTMAYEEQNKNVAAEIE 415
IN+ +AV+ ++ NK + E
Sbjct: 1687 INVVVAVLMKHLDDSNKEAQEDAE 1710
Score = 68.2 bits (165), Expect = 7e-11
Identities = 36/128 (28%), Positives = 72/128 (56%), Gaps = 15/128 (11%)
Query: 1208 INGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAV 1267
+N + +N+ N C +G+ + +NFDN+G A++ + QV T +GW++I+Y +
Sbjct: 310 LNASGLCVNWNRYYNV--CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367
Query: 1268 DSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTE 1327
D+ + +IYF++ II GSFF +NL + VI F++ +++ + M E
Sbjct: 368 DA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLE 414
Query: 1328 EQKKYYNA 1335
++++Y ++
Sbjct: 415 QRQRYLSS 422
Score = 50.8 bits (120), Expect = 1e-05
Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 21/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISM-MAESYNQPKAMKS---ILDHLNWVFV 1406
P N C +V + F+ + + +I+LN +++ M + + + IL +
Sbjct: 68 PRNWC----IKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIF 123
Query: 1407 VIFTLECLIKIFAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLF 1462
+ F +E ++K+ AL ++ Y + WN D +V+ +V + L+N
Sbjct: 124 IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-LQNIN--------L 174
Query: 1463 RIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R R+ R L+ + +R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 175 SAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
Score = 35.8 bits (81), Expect = 0.38
Identities = 22/76 (28%), Positives = 44/76 (57%), Gaps = 5/76 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++V+F+++ E W+E M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
Query: 815 S-NEERNGNLEGEARK 829
S ++R L E R+
Sbjct: 402 SETKQREHRLMLEQRQ 417
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 354 bits (908), Expect = 5e-97
Identities = 196/594 (32%), Positives = 337/594 (56%), Gaps = 34/594 (5%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C I+ H F+ ++ I L+ + E +E + L ++ IFT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
LK V+ G FG+ Y S+W LD +V VS+ ++ + L+ R LR
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ G+K+VV LI ++ I N++L+C F+++F ILGV F GKF C+
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
++ ITN+S C + N+ W++ K NFDN+G A ++L +A+ GW++I+Y +D+
Sbjct: 1338 ---VDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE K
Sbjct: 1395 VDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--K 1452
Query: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
++K K + P + L+ + TS DI I +I LN+++M E YNQP
Sbjct: 1453 RLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQP 1512
Query: 1392 KAMKSILDHLNWVFVVIFTLECLIKI--FALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449
++++ L + N++F +F LE ++K+ F LR+ +F + WN D +VLLS++ + +
Sbjct: 1513 TSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKDRWNQLDLAIVLLSVMGITLEEI 1571
Query: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509
E +P PT+ RI+R+ RI R+L+L++ A G+R LL ++ +LP + N+GLL L+ F
Sbjct: 1572 EINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 1631
Query: 1510 IYAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK 1564
IYA LG+ F K+ NP G+ F+ F + L LFQ+ST W+ ++ LR
Sbjct: 1632 IYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR-- 1689
Query: 1565 ESCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
C +C L ++ YFVS+++ + +++N+ +AV++++ + + +E+++
Sbjct: 1690 -DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
Score = 130 bits (328), Expect = 9e-30
Identities = 81/263 (30%), Positives = 137/263 (52%), Gaps = 14/263 (5%)
Query: 556 VWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLV 615
VW C W + LR ++ + I + I++NTV + +EHH+ +L I N+V
Sbjct: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
Query: 616 FTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVL 675
FTS+F EM LK+ A + Y R +NIFDSI+ ++S +++ LR+FR+L
Sbjct: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG--QADGGLSVLRTFRLL 736
Query: 676 RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKL 735
RV KL + P L + ++ ++ + + ++L++ IFIFS++GM +FG F+ L
Sbjct: 737 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS------L 790
Query: 736 CNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILI 794
TG TV +++ + + VF+IL E W ++ M + +SL F+ +
Sbjct: 791 RTDTGDTVPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL---YFVAL 845
Query: 795 TVIGKLVVLNLFIALLLNSFSNE 817
G V+ NL +A+L+ F E
Sbjct: 846 MTFGNYVLFNLLVAILVEGFQAE 868
Score = 119 bits (299), Expect = 2e-26
Identities = 84/349 (24%), Positives = 165/349 (47%), Gaps = 55/349 (15%)
Query: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163
++++F P N R L + H LF ++ + +NC+ +A P + S ++
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
Query: 164 CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219
+FT I++ E +K+++ G E ++LR WN LD ++ ++I+ + + K+L
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Query: 220 P-LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G C+ D +NI+N + + Y H K
Sbjct: 1329 KGKF-YHCLGVDTRNITN------------------------RSDCMAANYRWVHHKY-- 1361
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385
NFDN G + +++F L ++D W + QQ + + + +FI +
Sbjct: 1362 -----NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1416
Query: 386 LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA 434
+ SF+++N+ + VV + + ++ AE EA+ + + ++L K+ ++A
Sbjct: 1417 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLEKKRRKA 1464
Score = 116 bits (291), Expect = 2e-25
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 50/347 (14%)
Query: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKNSN--SNNTDIAEC 164
A F S R+ I++ + F + +++NCV + P + + S+ I +
Sbjct: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
Query: 165 VFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLP 220
I+IF E ++K++A G I + +L D WN LD ++ +V Y + I L
Sbjct: 118 FDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
Query: 221 LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLN 280
+RT RV R LKAI+ V ++++V LL ++ L NV++L FF IF ++G QL+ G L
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
Query: 281 LKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNS---------------ACSIQ 325
+C + I A ++ +E+ +C + N C +
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
Query: 326 YE---------------------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQ 358
+ C+ NP NFDN G++++ +F+++T
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITL 356
Query: 359 DSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
+ W ++ + Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 357 EGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 403
Score = 105 bits (262), Expect = 4e-22
Identities = 69/281 (24%), Positives = 138/281 (49%), Gaps = 33/281 (11%)
Query: 569 VLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 628
++ ++ T + ++ IT I +N V +++EH+ S E L N +FT++F+ E LK+
Sbjct: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538
Query: 629 IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK----RSWP-------FLRSFRVLRV 677
+A +F+ WN D + LLS VM L++ + P +R R+ RV
Sbjct: 1539 VAFGLRRFFKDRWNQLDLAIVLLS---VMGITLEEIEINAALPINPTIIRIMRVLRIARV 1595
Query: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN 737
KL K + L+ + ++ +G+L ++ +++ FI++ +G++LFG+ +CN
Sbjct: 1596 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK--------LVCN 1647
Query: 738 PTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV-------- 788
P RH +F +FL +F++ G+ W M + +++ C+
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
Query: 789 IVFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827
+ F+ + + V++N+ +A+L+ SN+E + E +A
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDA 1748
Score = 103 bits (258), Expect = 1e-21
Identities = 74/277 (26%), Positives = 137/277 (49%), Gaps = 28/277 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F+ I+ I++N +SM E + QP+ + +IL+ N VF +F LE ++K+ A
Sbjct: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD ++V++SI E + ++R R+ R+L+LVR
Sbjct: 696 LFDYLRNPYNIFDSIIVIISI----------WEIVGQADGGLSVLRTFRLLRVLKLVRFM 745
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535
+R L LM ++ ++ +LL L +FI++ILGM+ F + + + D NF
Sbjct: 746 PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
Query: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595
+ +++ +FQI T W+ +L + S A+ YFV+ + ++
Sbjct: 806 SLLWAIVTVFQILTQEDWNVVLYNGMASTSPW------------ASLYFVALMTFGNYVL 853
Query: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEK 1632
N+ +A+++E F + + ED E ++K
Sbjct: 854 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
Score = 99.0 bits (245), Expect = 4e-20
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 40/279 (14%)
Query: 1041 IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHI 1100
+W R IV +F I+ IL+++ ++ E H E ++ +L +++FT +
Sbjct: 625 VWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSM 682
Query: 1101 FILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPL 1155
F LEM+LK AFG Y + + D IIVI+S+ ++ L L++FR LR L+ +
Sbjct: 683 FALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV 742
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVI 1215
R + VV L+ + + ++ ++F +F ILG++ F KF + D+V
Sbjct: 743 RFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTV- 798
Query: 1216 NYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQ 1275
+ NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 799 -------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----- 834
Query: 1276 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+ +YFV + FG++ NL + ++++ F +
Sbjct: 835 -----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 868
Score = 90.5 bits (223), Expect = 1e-17
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 14/168 (8%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVH-LENQPKIQELLNCTDIIFTHI 1100
R C ++V + WFE + VILL+ L +D+ L ++ KI ++ + D IF
Sbjct: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFD--DFIFI-F 125
Query: 1101 FILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTL---INLMELKSFRTLRALRP 1154
F +EMVLK VA G FGK Y W LDF IV+ + + + L + RT+R LRP
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
Query: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
L+A+++ M+++VN L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 86.7 bits (213), Expect = 2e-16
Identities = 71/327 (21%), Positives = 138/327 (42%), Gaps = 60/327 (18%)
Query: 131 FSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
F+ I+ +++N V M + +N +I VFT ++ E ++K+ A G F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
Query: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
+LR+P+N DSI++ I+I + L LRTFR+ R LK + + L+ + L++
Sbjct: 698 DYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMK 757
Query: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSP 308
++ + +L + IF+++G +F CK + D ++K
Sbjct: 758 TMDNVATFCMLLMLFIFIFSILGMHIF-----------GCKFSLRTDTGDTVPDRK---- 802
Query: 309 EFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQT 368
NFD+ W+ + +F+++TQ+ W +
Sbjct: 803 --------------------------------NFDSLLWAIVTVFQILTQEDWNVVLYNG 830
Query: 369 LRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLL 428
+ +T ++ +F+ ++ G++ L NL +A++ ++ AE +A E Q
Sbjct: 831 MASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQ-------AEGDANRSYSDEDQSSS 883
Query: 429 KEEKEALVAMGIDRSSLTSLETSYFTP 455
E+ + G+D S L TP
Sbjct: 884 NIEEFDKLQEGLDSSGDPKLCPIPMTP 910
Score = 83.2 bits (204), Expect = 2e-15
Identities = 68/321 (21%), Positives = 142/321 (44%), Gaps = 37/321 (11%)
Query: 571 RTVMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKI 628
+T++ + + I +N + +A+E ++EA S E++ L + N +FT+IF+ EM LK+
Sbjct: 1164 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1223
Query: 629 IALDPYH----YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684
++L Y Y R WN+ D + +S D++ + L RVLR+ + +
Sbjct: 1224 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL 1283
Query: 685 ------PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSF------NSQKS 732
P L +++ + +S+ +G++ ++ IF ++G+QLF F +++
Sbjct: 1284 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI 1343
Query: 733 PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECM-------QEANAS 783
+ + H + D L+ +L + W+ M+ + Q
Sbjct: 1344 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH 1403
Query: 784 SSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRR- 841
+ ++ FI +I VLN+F+ +++ +F ++ E R+ + +L L++ RR
Sbjct: 1404 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK 1463
Query: 842 --------AFCFVRHTLEHFC 854
+C R + C
Sbjct: 1464 AQRLPYYATYCHTRLLIHSMC 1484
Score = 80.1 bits (196), Expect = 2e-14
Identities = 68/324 (20%), Positives = 136/324 (41%), Gaps = 87/324 (26%)
Query: 124 RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176
R+ +HS+ +FI + +N V M+ S T + C +FT +++ EA++
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1536
Query: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222
K++A G F +D WN LD ++ ++++ GIT++ LP+ R
Sbjct: 1537 KLVAFGLR----RFFKDRWNQLDLAIVLLSVM----GITLEEIEINAALPINPTIIRIMR 1588
Query: 223 TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
R+ R LK + + + ++ ++ +++++ ++ N+ +L I+A +G +LF
Sbjct: 1589 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1641
Query: 283 CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342
G C+ + C+ + F
Sbjct: 1642 -----------------------------------GKLVCNDENPCEGMS-----RHATF 1661
Query: 343 DNFGWSFLAMFRLMTQDSWEKLYQQTLR-----------TTGLYSVFFFIVVIFLGSFYL 391
+NFG +FL +F++ T D+W + + TLR + S +F+ + F L
Sbjct: 1662 ENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVL 1721
Query: 392 INLTLAVVTMAYEEQNKNVAAEIE 415
IN+ +AV+ ++ NK + E
Sbjct: 1722 INVVVAVLMKHLDDSNKEAQEDAE 1745
Score = 68.2 bits (165), Expect = 7e-11
Identities = 36/128 (28%), Positives = 72/128 (56%), Gaps = 15/128 (11%)
Query: 1208 INGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAV 1267
+N + +N+ N C +G+ + +NFDN+G A++ + QV T +GW++I+Y +
Sbjct: 310 LNASGLCVNWNRYYNV--CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367
Query: 1268 DSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTE 1327
D+ + +IYF++ II GSFF +NL + VI F++ +++ + M E
Sbjct: 368 DA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLE 414
Query: 1328 EQKKYYNA 1335
++++Y ++
Sbjct: 415 QRQRYLSS 422
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/170 (25%), Positives = 82/170 (48%), Gaps = 13/170 (7%)
Query: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEH--HKMEASFE--KMLNIGNLVF 616
P+ C+K V +P+ E + I++N V L M M+ + K+L + +
Sbjct: 68 PRNWCIKMVC-----NPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFI 122
Query: 617 TSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFR 673
F EM LK++AL + Y WN D + + + + LQ + +R+ R
Sbjct: 123 FIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEY-SLDLQNINLSAIRTVR 181
Query: 674 VLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
VLR K P++ L+ ++ +++ LG++ ++ V FIF ++G+QL+
Sbjct: 182 VLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 50.8 bits (120), Expect = 1e-05
Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 21/174 (12%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISM-MAESYNQPKAMKS---ILDHLNWVFV 1406
P N C +V + F+ + + +I+LN +++ M + + + IL +
Sbjct: 68 PRNWC----IKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIF 123
Query: 1407 VIFTLECLIKIFAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLF 1462
+ F +E ++K+ AL ++ Y + WN D +V+ +V + L+N
Sbjct: 124 IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-LQNIN--------L 174
Query: 1463 RIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R R+ R L+ + +R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 175 SAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
Score = 35.8 bits (81), Expect = 0.38
Identities = 22/76 (28%), Positives = 44/76 (57%), Gaps = 5/76 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++V+F+++ E W+E M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
Query: 815 S-NEERNGNLEGEARK 829
S ++R L E R+
Sbjct: 402 SETKQREHRLMLEQRQ 417
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 353 bits (906), Expect = 8e-97
Identities = 187/593 (31%), Positives = 339/593 (57%), Gaps = 32/593 (5%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R +C +++ H F+ ++ I L+ + E ++ + L+ ++ IFT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1106 VLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
++K VA G Y S+W LD ++V+VS+ ++ M L+ R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ G+K+VV LI ++ I N++L+C F+++F ILGV F GKF C G
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC-EGP 1462
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ I+ K+QC + ++ W+ +K NFDN+G A ++L +++ GW++I+Y +D+
Sbjct: 1463 DT----RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE K
Sbjct: 1519 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--K 1576
Query: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
+++ K ++P + + + + TS D+ I +I +N+I+M E YNQP
Sbjct: 1577 RLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQP 1636
Query: 1392 KAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVSTMISTLE 1450
K++ L + N+VF ++F E +K+ A + +F + WN D +VLLS++ + +E
Sbjct: 1637 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1696
Query: 1451 NQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFI 1510
+P PT+ RI+R+ RI R+L+L++ A G+R LL ++ +LP + N+GLL L+ FI
Sbjct: 1697 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1756
Query: 1511 YAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKE 1565
YA LG+ F ++ NP G+ F F + L LF++ST W+ ++ LR
Sbjct: 1757 YAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR--- 1813
Query: 1566 SCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
C+ ++C +LP ++ YFV++++++ ++VN+ +AV++++ + +E+ +
Sbjct: 1814 ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE 1866
Score = 128 bits (321), Expect = 6e-29
Identities = 81/276 (29%), Positives = 139/276 (50%), Gaps = 14/276 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W+ LR ++ + I + I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 779 WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++A P Y R +NIFD I+ ++S +++ LR+FR+LRV KL +
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVG--QADGGLSVLRTFRLLRVLKLVR 896
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + +L++ IFIFS++GM LFG F+ L TG T
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS------LKTDTGDT 950
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
V +++ + + VF+IL E W ++ M ++SS + F+ + G V
Sbjct: 951 VPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMA---STSSWAALYFVALMTFGNYV 1005
Query: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALD 837
+ NL +A+L+ F E + + KT V D
Sbjct: 1006 LFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEED 1041
Score = 119 bits (299), Expect = 2e-26
Identities = 95/358 (26%), Positives = 161/358 (44%), Gaps = 50/358 (13%)
Query: 97 KRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN-- 153
+R Y A F G RS +R+ + F + +++NCV + P ++
Sbjct: 68 QRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVE 127
Query: 154 SNSNNTDIAECVFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSY 210
S +I E I+ F E +IK++A G + + +L D WN LD ++ ++ Y
Sbjct: 128 CGSERCNILEAFDAFIFAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEY 186
Query: 211 -IPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFAL 269
+ G + L +RT RV R L+AI+ V ++++V LL ++ L NV++L FF IF +
Sbjct: 187 SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 246
Query: 270 VGQQLFMGSLNLKCISRDC----KNISNPEAYDHCFEKKEN------------------- 306
VG QL+ G L +C N++ Y E +EN
Sbjct: 247 VGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP 306
Query: 307 -SPEFKM-C-------------GIWMGNSAC----SIQYECKHTKINPDYNYTNFDNFGW 347
E +M C G+ +AC C+ NP NFDN G+
Sbjct: 307 GRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGY 366
Query: 348 SFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
+++A+F+++T + W + + Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 367 AWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 424
Score = 115 bits (288), Expect = 4e-25
Identities = 88/373 (23%), Positives = 174/373 (46%), Gaps = 60/373 (16%)
Query: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163
AL++F P N R +V H +F ++ + +NCV +A P + S ++
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
Query: 164 CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219
+FT I++ E ++K++A G + E ++L+ WN LD +++ +++V + + K+L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
Query: 220 -PLRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
LR R+ R L+ + V+SR LK++V L+ S++ + N++++ IF ++G QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G C D +NIS + +C+
Sbjct: 1453 KGKF-YYCEGPDTRNIST-------------------------------KAQCRAAHYRW 1480
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385
NFDN G + +++F L ++D W + QQ ++ + + +FI +
Sbjct: 1481 VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL 1540
Query: 386 LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA-----LVAMGI 440
+ SF+++N+ + VV + + ++ AE EA+ + + ++L + ++A
Sbjct: 1541 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLERRRRKAQRRPYYADYSP 1599
Query: 441 DRSSLTSLETSYF 453
R S+ SL TS++
Sbjct: 1600 TRRSIHSLCTSHY 1612
Score = 110 bits (275), Expect = 1e-23
Identities = 69/280 (24%), Positives = 138/280 (49%), Gaps = 27/280 (9%)
Query: 567 KKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCL 626
++ + ++ T + +L IT I +N + ++MEH+ S ++ L N VFT +F+ E L
Sbjct: 1601 RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAAL 1660
Query: 627 KIIALDPYHYFRRGWNIFDSIVALLSFADV-MNCVLQKRSWP-------FLRSFRVLRVF 678
K++A +F+ WN D + LLS + + + + P +R R+ RV
Sbjct: 1661 KLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVL 1720
Query: 679 KLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNP 738
KL K + L+ + ++ +G+L ++ +++ FI++ +G++LFGR C+
Sbjct: 1721 KLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--------LECSE 1772
Query: 739 TGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV--------I 789
P RH +F +FL +FR+ G+ W M + ++E + C+ +
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1832
Query: 790 VFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827
F+ ++ + V++N+ +A+L+ SN+E + E +A
Sbjct: 1833 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDA 1872
Score = 102 bits (254), Expect = 3e-21
Identities = 73/273 (26%), Positives = 132/273 (48%), Gaps = 28/273 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+ A
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
Y N +N+FD ++V++S+ E + ++R R+ R+L+LVR
Sbjct: 849 PLGYIRNPYNIFDGIIVVISV----------WEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535
+R L L+ ++ ++ LL L +FI++ILGM+ F K + + D NF
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFD 958
Query: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595
+ +++ +FQI T W+ +L + S S A YFV+ + ++
Sbjct: 959 SLLWAIVTVFQILTQEDWNVVLYNGMASTSSW------------AALYFVALMTFGNYVL 1006
Query: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYE 1628
N+ +A+++E F + + ED + +E
Sbjct: 1007 FNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
Score = 96.3 bits (238), Expect = 2e-19
Identities = 70/292 (23%), Positives = 136/292 (46%), Gaps = 31/292 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P N+ + ++T ++FD +++ I LN +++ E + + L N++F I
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E ++K+ AL Y + WNL D ++VL+S+V +++ + R
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL--GVLR 1396
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A G++ ++ L+ SL + NI L+ I+ ILG+ F
Sbjct: 1397 VLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKF 1456
Query: 1521 -----------------KVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ + +NF +++ LF +S+ GW +++ L +
Sbjct: 1457 YYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA 1516
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESE 1615
+N H P + YF+S+++I V+NM++ V++ENF+ + E
Sbjct: 1517 VGVDQQPVQN-HNPWMLL-YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQE 1566
Score = 92.4 bits (228), Expect = 3e-18
Identities = 71/286 (24%), Positives = 133/286 (46%), Gaps = 42/286 (14%)
Query: 1036 KPPWV--IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCT 1093
+P W+ +W +IV +F I+ IL+++ ++ E + E ++ L +
Sbjct: 771 EPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEIS 828
Query: 1094 DIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRT 1148
+I+FT +F LEM+LK +A G Y + + D IIV++SV ++ L L++FR
Sbjct: 829 NIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRL 888
Query: 1149 LRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCI 1208
LR L+ +R L VV L+ + + + ++F +F ILG++ F KF
Sbjct: 889 LRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKT 945
Query: 1209 NGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268
+ D+V + NFD++ A + + Q+ T + W ++Y +
Sbjct: 946 DTGDTV--------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985
Query: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
ST +S +YFV + FG++ NL + ++++ F +
Sbjct: 986 ST----------SSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 88.2 bits (217), Expect = 7e-17
Identities = 76/335 (22%), Positives = 139/335 (41%), Gaps = 87/335 (25%)
Query: 124 RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176
R S+HSL +FI + +N + M+ S + + C VFT +++FEA +
Sbjct: 1601 RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAAL 1660
Query: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222
K++A GF F +D WN LD ++ ++++ GIT++ LP+ R
Sbjct: 1661 KLVAFGFR----RFFKDRWNQLDLAIVLLSLM----GITLEEIEMSAALPINPTIIRIMR 1712
Query: 223 TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
R+ R LK + + + ++ ++ +++++ ++ N+ +L I+A +G +LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1765
Query: 283 CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342
G CS C+ + F
Sbjct: 1766 -----------------------------------GRLECSEDNPCEGLS-----RHATF 1785
Query: 343 DNFGWSFLAMFRLMTQDSWEKLYQQTLRTTG-----------LYSVFFFIVVIFLGSFYL 391
NFG +FL +FR+ T D+W + + TLR S +F+ + + F L
Sbjct: 1786 SNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVL 1845
Query: 392 INLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQ 426
+N+ +AV+ EE NK + E ++ E Q
Sbjct: 1846 VNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1880
Score = 85.9 bits (211), Expect = 3e-16
Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C ++V + WFE + VI+L+ L EDV ++ +L D F
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLI---NLMELKSFRTLRALRPL 1155
+EMV+K VA G FG+ Y W LDF IV+ + + + L + RT+R LRPL
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
Score = 85.9 bits (211), Expect = 3e-16
Identities = 68/297 (22%), Positives = 141/297 (47%), Gaps = 28/297 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKME-ASFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
V+T + + + I +N V +A+E ++ S E++ L++ N +FT+IF+AEM +K++A
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVA 1349
Query: 631 L----DPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW-- 684
L + Y + WN+ D ++ L+S D++ + L RVLR+ + +
Sbjct: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409
Query: 685 ----PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
P L +++ + +S+ +G++ ++ IF ++G+QLF F + P N +
Sbjct: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469
Query: 741 PTVSCLRHWHMGDFWHSF------LVVFRILCGE--WIENMWECM-------QEANASSS 785
H+ ++F L+ +L + W+ M++ + Q +
Sbjct: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRR 841
++ FI +I VLN+F+ +++ +F ++ E R+ + +L L+R RR
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR 1586
Score = 85.5 bits (210), Expect = 4e-16
Identities = 68/311 (21%), Positives = 137/311 (44%), Gaps = 55/311 (17%)
Query: 124 RVSVHSLFSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILAR 181
R+ FS I+ +++N + M + +N +I+ VFT ++ E L+K+LA
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
Query: 182 GFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKV 241
G ++R+P+N D I++ I++ + L LRTFR+ R LK + + L+
Sbjct: 848 G----PLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRR 903
Query: 242 IVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCF 301
+ L++++ + L + IF+++G LF +LK + D
Sbjct: 904 QLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGD-------------- 949
Query: 302 EKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSW 361
P+ K NFD+ W+ + +F+++TQ+ W
Sbjct: 950 ----TVPDRK-----------------------------NFDSLLWAIVTVFQILTQEDW 976
Query: 362 EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYE-EQNKNVAAEIEAKEKM 420
+ + +T ++ +F+ ++ G++ L NL +A++ ++ E + N + E K +
Sbjct: 977 NVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSV 1036
Query: 421 -FQEAQQLLKE 430
F+E L+E
Sbjct: 1037 HFEEDFHKLRE 1047
Score = 72.8 bits (177), Expect = 3e-12
Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 13/135 (9%)
Query: 1226 CESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGY 1285
C SG+ + N +NFDN+G A++A+ QV T +GW+DI+Y +D+ + +
Sbjct: 347 CRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNF 396
Query: 1286 IYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1345
IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 397 IYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEP 453
Query: 1346 KPIPRPLNKCQGLVF 1360
L K G +F
Sbjct: 454 GSCYEELLKYVGHIF 468
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 23/226 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISM----MAESYNQPKAMKSILDHLNWVFVVIFTLECLIKI 1417
+V + F+ + + +I+LN +++ E +IL+ + F +E +IK+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 1418 FAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRI 1473
AL ++ Y + WN D +V + M +L+ +R R+ R
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIV---VAGMMEYSLDGHN------VSLSAIRTVRVLRP 206
Query: 1474 LRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMN-WFSKVNPESGIDDIF 1532
LR + +R L+ L+ +LP L N+ LL F + FI+ I+G+ W + +D F
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Query: 1533 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPG 1578
+ + +Q T G + +P + S N + H+PG
Sbjct: 267 VRNNNLTFLRPYYQ--TEEGEE---NPFICSSRRDNGMQKCSHIPG 307
Score = 50.1 bits (118), Expect = 2e-05
Identities = 41/160 (25%), Positives = 78/160 (48%), Gaps = 12/160 (7%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEH--HKMEASFEK--MLNIGNLVFTSIFIAEMCLKI 628
++ +P+ E + I++N V L M +E E+ +L + + F EM +K+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 629 IALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKR--SWPFLRSFRVLRVFKLAKS 683
+AL + Y WN D + + A +M L S +R+ RVLR +
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVV---AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINR 212
Query: 684 WPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 213 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 422
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 423 SETKQRESQLMREQR 437
Score = 31.6 bits (70), Expect = 7.2
Identities = 22/94 (23%), Positives = 40/94 (42%), Gaps = 16/94 (17%)
Query: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
NP +G NF + + +FQ+ T GW ++ ++ + N
Sbjct: 353 NPHNGA---INFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFI------------ 397
Query: 1583 YFVSYIIISFLIVVNMYIAVILENFN-TATEESE 1615
YF+ II+ ++N+ + VI F+ T ES+
Sbjct: 398 YFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1777 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
Score = 125 bits (315), Expect = 3e-28
Identities = 75/265 (28%), Positives = 137/265 (51%), Gaps = 15/265 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGE 826
+ NL +A+L+ F E E E
Sbjct: 955 LFNLLVAILVEGFQAEGDANKSESE 979
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1545
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1547 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1593
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1714 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1766 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1825
Query: 820 NGNLEGE 826
E E
Sbjct: 1826 EAKEEAE 1832
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/267 (26%), Positives = 131/267 (49%), Gaps = 28/267 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
N+ +A+++E F A ++ E DF
Sbjct: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1671
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1672 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1732 ------------------------------------------GDLECDETHPCEGLG--- 1746
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1747 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1546
Score = 85.5 bits (210), Expect = 4e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQNKNVAAEIE 415
+A++ ++ + +E E
Sbjct: 960 VAILVEGFQAEGDANKSESE 979
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1777 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
Score = 125 bits (315), Expect = 3e-28
Identities = 75/265 (28%), Positives = 137/265 (51%), Gaps = 15/265 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGE 826
+ NL +A+L+ F E E E
Sbjct: 955 LFNLLVAILVEGFQAEGDANKSESE 979
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1545
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1547 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1593
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1714 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1766 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1825
Query: 820 NGNLEGE 826
E E
Sbjct: 1826 EAKEEAE 1832
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/267 (26%), Positives = 131/267 (49%), Gaps = 28/267 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
N+ +A+++E F A ++ E DF
Sbjct: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1671
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1672 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1732 ------------------------------------------GDLECDETHPCEGLG--- 1746
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1747 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1546
Score = 85.5 bits (210), Expect = 4e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQNKNVAAEIE 415
+A++ ++ + +E E
Sbjct: 960 VAILVEGFQAEGDANKSESE 979
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1444
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1445 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1559
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1560 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1800 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852
Score = 130 bits (328), Expect = 9e-30
Identities = 77/276 (27%), Positives = 145/276 (52%), Gaps = 15/276 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALD 837
+ NL +A+L+ F EE + + + + +QL +D
Sbjct: 955 LFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVD 990
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1437 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1467
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1468 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1524
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1525 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1568
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1378
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1439 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1498
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1499 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1570 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1616
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1737 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1788
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1789 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1848
Query: 820 NGNLEGE 826
E E
Sbjct: 1849 EAKEEAE 1855
Score = 96.3 bits (238), Expect = 2e-19
Identities = 71/265 (26%), Positives = 130/265 (49%), Gaps = 28/265 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNT-ATEESEDPLGE 1620
N+ +A+++E F + ED G+
Sbjct: 957 NLLVAILVEGFQAEEISKREDASGQ 981
Score = 91.7 bits (226), Expect = 6e-18
Identities = 65/279 (23%), Positives = 132/279 (47%), Gaps = 41/279 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
+S +YF+ + FG++ NL + ++++ F ++
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1583 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1642
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1643 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1694
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1695 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1755 ------------------------------------------GDLECDETHPCEGLG--- 1769
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1770 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1867
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1452 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1511
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1512 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1569
Score = 84.7 bits (208), Expect = 7e-16
Identities = 54/251 (21%), Positives = 114/251 (45%), Gaps = 52/251 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQ 406
+A++ ++ +
Sbjct: 960 VAILVEGFQAE 970
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1777 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
Score = 125 bits (315), Expect = 3e-28
Identities = 75/265 (28%), Positives = 137/265 (51%), Gaps = 15/265 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGE 826
+ NL +A+L+ F E E E
Sbjct: 955 LFNLLVAILVEGFQAEGDANKSESE 979
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1545
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1547 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1593
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1714 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1766 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1825
Query: 820 NGNLEGE 826
E E
Sbjct: 1826 EAKEEAE 1832
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/267 (26%), Positives = 131/267 (49%), Gaps = 28/267 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
N+ +A+++E F A ++ E DF
Sbjct: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1671
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1672 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1732 ------------------------------------------GDLECDETHPCEGLG--- 1746
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1747 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1546
Score = 85.5 bits (210), Expect = 4e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQNKNVAAEIE 415
+A++ ++ + +E E
Sbjct: 960 VAILVEGFQAEGDANKSESE 979
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1444
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1445 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1559
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1560 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1619
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1620 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1679
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1680 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1739
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1740 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1799
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1800 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852
Score = 130 bits (328), Expect = 9e-30
Identities = 77/276 (27%), Positives = 145/276 (52%), Gaps = 15/276 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALD 837
+ NL +A+L+ F EE + + + + +QL +D
Sbjct: 955 LFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVD 990
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1437 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1467
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1468 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1524
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1525 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1568
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1378
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1439 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1498
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1499 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1549
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1570 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1616
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1737 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1788
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1789 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1848
Query: 820 NGNLEGE 826
E E
Sbjct: 1849 EAKEEAE 1855
Score = 96.3 bits (238), Expect = 2e-19
Identities = 71/265 (26%), Positives = 130/265 (49%), Gaps = 28/265 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNT-ATEESEDPLGE 1620
N+ +A+++E F + ED G+
Sbjct: 957 NLLVAILVEGFQAEEISKREDASGQ 981
Score = 91.7 bits (226), Expect = 6e-18
Identities = 65/279 (23%), Positives = 132/279 (47%), Gaps = 41/279 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
+S +YF+ + FG++ NL + ++++ F ++
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1583 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1642
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1643 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1694
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1695 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1755 ------------------------------------------GDLECDETHPCEGLG--- 1769
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1770 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1867
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1452 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1511
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1512 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1569
Score = 84.7 bits (208), Expect = 7e-16
Identities = 54/251 (21%), Positives = 114/251 (45%), Gaps = 52/251 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQ 406
+A++ ++ +
Sbjct: 960 VAILVEGFQAE 970
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 350 bits (898), Expect = 7e-96
Identities = 198/597 (33%), Positives = 339/597 (56%), Gaps = 36/597 (6%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ E+K+
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKR 1536
Query: 1332 YYNAMKKLGSKKPQ------KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMA 1385
KK SK+ Q KP ++ + LV + TS D+ I +I LN+++M
Sbjct: 1537 LRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1596
Query: 1386 ESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVST 1444
E Y QP+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+
Sbjct: 1597 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656
Query: 1445 MISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLL 1504
+ +E +P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716
Query: 1505 FLIMFIYAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSP 1559
L+ FI+A LG+ F + +P G+ F+ F + L LF++ST W+ ++
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776
Query: 1560 MLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
LR C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1777 TLR---DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
Score = 125 bits (315), Expect = 3e-28
Identities = 75/265 (28%), Positives = 137/265 (51%), Gaps = 15/265 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGE 826
+ NL +A+L+ F E E E
Sbjct: 955 LFNLLVAILVEGFQAEGDANKSESE 979
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 113 bits (283), Expect = 1e-24
Identities = 83/345 (24%), Positives = 164/345 (47%), Gaps = 55/345 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432
+F+++N+ + VV + + ++ E EA+ + + ++L K+ +
Sbjct: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRR 1545
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 103 bits (257), Expect = 2e-21
Identities = 79/307 (25%), Positives = 142/307 (46%), Gaps = 35/307 (11%)
Query: 534 KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593
KE++ ++ C P S Y + LC T + +L IT I +N V
Sbjct: 1547 KEKQMAEAQCKP----YYSDYSRFRLLVHHLC---------TSHYLDLFITGVIGLNVVT 1593
Query: 594 LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653
+AMEH++ ++ L I N +FT IF+ E K++A +F+ WN D + LLS
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653
Query: 654 ADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLT 705
+ + + S P +R R+ RV KL K + L+ + ++ +G+L
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713
Query: 706 VVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRIL 765
++ +++ FIF+ +G++LFG C+ T P RH +F +FL +FR+
Sbjct: 1714 LLFMLLFFIFAALGVELFG--------DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 766 CGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEER 819
G+ W + + +C QE+ ++ + I F+ + + V++N+ IA+L+ +
Sbjct: 1766 TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1825
Query: 820 NGNLEGE 826
E E
Sbjct: 1826 EAKEEAE 1832
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/267 (26%), Positives = 131/267 (49%), Gaps = 28/267 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
N+ +A+++E F A ++ E DF
Sbjct: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1560 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1619
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1620 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1671
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1672 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1732 ------------------------------------------GDLECDETHPCEGLG--- 1746
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1747 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 86.7 bits (213), Expect = 2e-16
Identities = 67/298 (22%), Positives = 138/298 (46%), Gaps = 28/298 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 741 ------PTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANAS-------SS 785
+ +RH + D L+ +L + W++ M++ + +
Sbjct: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSN-EERNGNLEGEARKTKVQLALDRFRRA 842
++ FI +I VLN+F+ +++ +F + E R+ K L++ RR+
Sbjct: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRS 1546
Score = 85.5 bits (210), Expect = 4e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQNKNVAAEIE 415
+A++ ++ + +E E
Sbjct: 960 VAILVEGFQAEGDANKSESE 979
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 350 bits (897), Expect = 9e-96
Identities = 196/591 (33%), Positives = 336/591 (56%), Gaps = 31/591 (5%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
R C++I+ H F+ ++ +I L+ + E ++ + L ++ IFT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
+K VA G FG+ Y S+W LD ++V++SV ++ M L+ R LR
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
LRPLR +S+ +G+K+VV L+ ++ I N++++C F+++F ILGV F GKF C G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-QGE 1421
Query: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
D+ ITNKS C ++ W+ K NFDN+G A ++L +A+ GW+DI+Y +D+
Sbjct: 1422 DT----RNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
+QQP N +YF+ F++ +FF LN+F+GV+++NF++ ++ ++ EE K
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE--K 1535
Query: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
++K K KP ++ + LV + TS D+ I +I LN+++M E Y QP
Sbjct: 1536 RLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQP 1595
Query: 1392 KAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVSTMISTLE 1450
+ + L N++F VIF LE + K+ A + +F + WN D +VLLSI+ + +E
Sbjct: 1596 QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIE 1655
Query: 1451 NQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFI 1510
+P PT+ RI+R+ RI R+L+L++ A G+R LL +M +LP + N+GLL L+ FI
Sbjct: 1656 VNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFI 1715
Query: 1511 YAILGMNWF-----SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKE 1565
+A LG+ F + +P G+ F+ F + L LF++ST W+ ++ LR
Sbjct: 1716 FAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR--- 1772
Query: 1566 SCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
C+ S C+ I+ YFVS+++ + ++VN+ IAV++++ + +E+++
Sbjct: 1773 DCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822
Score = 125 bits (315), Expect = 3e-28
Identities = 75/265 (28%), Positives = 137/265 (51%), Gaps = 15/265 (5%)
Query: 563 WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622
W + R ++ + I I I++NT+ + +E+H+ L I N+VFTS+F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
Query: 623 EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682
EM LK++ P+ Y + +NIFD ++ ++S +++ Q LR+FR++RV KL +
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG--QQGGGLSVLRTFRLMRVLKLVR 846
Query: 683 SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742
P L + ++ ++ + + ++L++ IFIFS++GM LFG F S++ G T
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-------GDT 899
Query: 743 VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801
+ +++ + + VF+IL E W + ++ M ++SS + FI + G V
Sbjct: 900 LPDRKNF--DSLLWAIVTVFQILTQEDWNKVLYNGMA---STSSWAALYFIALMTFGNYV 954
Query: 802 VLNLFIALLLNSFSNEERNGNLEGE 826
+ NL +A+L+ F E E E
Sbjct: 955 LFNLLVAILVEGFQAEGDANKSESE 979
Score = 116 bits (290), Expect = 2e-25
Identities = 89/333 (26%), Positives = 154/333 (46%), Gaps = 49/333 (14%)
Query: 119 RSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN--SNSNNTDIAECVFTGIYIF--- 172
RS +R + F + +++NCV + P ++ +S I + I+ F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
Query: 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLPLRTFRVFRALK 231
E ++K++A G I + +L D WN LD ++ ++ Y + + +RT RV R L+
Sbjct: 131 EMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189
Query: 232 AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC-------- 283
AI+ V ++++V LL ++ L NV++L FF IF +VG QL+ G L +C
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249
Query: 284 -ISRDCKNISNPEAYDH----CFEKKENSPEFKMC-------GIWMGNSACSIQYE---- 327
+S D + E D C + +EN + C G G C + YE
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENG--MRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query: 328 ---------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372
C + NP NFDN G++++A+F+++T + W + +
Sbjct: 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
Query: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 400
Score = 115 bits (288), Expect = 4e-25
Identities = 84/347 (24%), Positives = 166/347 (47%), Gaps = 55/347 (15%)
Query: 110 FIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAK----NSNSNNTDIAECV 165
+IF P + R L R+ H +F ++ + +NC+ +A K ++ ++ +
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293
Query: 166 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAI----VSYIPGITIKLLP- 220
FT +++ E +K++A G+ E ++LR WN LD +++ I++ VS + K+L
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353
Query: 221 LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMG 277
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Query: 278 SLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDY 337
C D +NI+N S C+ E + + Y
Sbjct: 1414 KF-FVCQGEDTRNITN-------------------------KSDCA---EASYRWVRHKY 1444
Query: 338 NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL----------YSVFFFIVVIFLG 387
NFDN G + +++F L ++D W + L G+ + + +FI + +
Sbjct: 1445 ---NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIV 1501
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA 434
+F+++N+ + VV + + ++ E EA+ + + ++L K+ ++A
Sbjct: 1502 AFFVLNMFVGVVVENFHKCRQHQEEE-EARRREEKRLRRLEKKRRKA 1547
Score = 103 bits (258), Expect = 1e-21
Identities = 72/293 (24%), Positives = 143/293 (48%), Gaps = 31/293 (10%)
Query: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408
P ++ + L I+T ++FD +++ +I LN I++ E + A + L N++F +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463
F E +K+ AL Q Y + WN+ D ++VL+S++ ++S + + + R
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL--GMLR 1355
Query: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520
++RL R R LR++ A+G++ ++ LM SL + NI ++ I+ ILG+ F
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1521 ---------KVNPESGIDDI--------FNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563
+ +S + +NF +++ LF +++ GW ++ L +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
N H P + YF+S+++I V+NM++ V++ENF+ + E+
Sbjct: 1476 VGVDQQPIMN-HNPWMLL-YFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEE 1526
Score = 102 bits (255), Expect = 3e-21
Identities = 71/266 (26%), Positives = 129/266 (48%), Gaps = 22/266 (8%)
Query: 575 TDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPY 634
T + +L IT I +N V +AMEH++ ++ L I N +FT IF+ E K++A
Sbjct: 1568 TSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFR 1627
Query: 635 HYFRRGWNIFDSIVALLSFADV-MNCVLQKRSWP-------FLRSFRVLRVFKLAKSWPT 686
+F+ WN D + LLS + + + S P +R R+ RV KL K
Sbjct: 1628 RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVG 1687
Query: 687 LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCL 746
+ L+ + ++ +G+L ++ +++ FIF+ +G++LFG C+ T P
Sbjct: 1688 MRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--------DLECDETHPCEGLG 1739
Query: 747 RHWHMGDFWHSFLVVFRILCGE-W----IENMWECMQEANA-SSSLCVIVFILITVIGKL 800
RH +F +FL +FR+ G+ W + + +C QE+ ++ + I F+ + +
Sbjct: 1740 RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1799
Query: 801 VVLNLFIALLLNSFSNEERNGNLEGE 826
V++N+ IA+L+ + E E
Sbjct: 1800 VLVNVVIAVLMKHLEESNKEAKEEAE 1825
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/267 (26%), Positives = 131/267 (49%), Gaps = 28/267 (10%)
Query: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
IV S+ F I+ I++N +SM E + QP+ + + L+ N VF +F LE L+K+
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
+ Y N +N+FD V+V++S+ E + ++R R+ R+L+LVR
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV----------WEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
Query: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNW----FSKVNPESGIDDIFNFKT 1536
++ L LM ++ ++ +LL L +FI++ILGM+ F+ + D NF +
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908
Query: 1537 FASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVV 1596
+++ +FQI T W+ +L + S S A YF++ + ++
Sbjct: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSW------------AALYFIALMTFGNYVLF 956
Query: 1597 NMYIAVILENFNTATEESEDPLGEDDF 1623
N+ +A+++E F A ++ E DF
Sbjct: 957 NLLVAILVEGFQ-AEGDANKSESEPDF 982
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/278 (23%), Positives = 131/278 (47%), Gaps = 41/278 (14%)
Query: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101
W + T +IV +F I+ IL+++ ++ E + E ++ L ++I+FT +F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786
Query: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPLR 1156
LEM+LK + +G Y + + D +IV++SV ++ L L++FR +R L+ +R
Sbjct: 787 ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 1157 ALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVIN 1216
L + VV L+ + + ++ ++F +F ILG++ F KF +G
Sbjct: 847 FLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG------ 897
Query: 1217 YTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP 1276
+ + NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 898 ---------------DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
Query: 1277 EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
+S +YF+ + FG++ NL + ++++ F +
Sbjct: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Score = 88.6 bits (218), Expect = 5e-17
Identities = 62/167 (37%), Positives = 92/167 (55%), Gaps = 12/167 (7%)
Query: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101
R C + V + WFE + VILL+ L ED+ ++Q + + L D IF F
Sbjct: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFA-FF 128
Query: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLINLMELKSF---RTLRALRPL 1155
+EMV+K VA G FGK Y W LDF IVI + ++ SF RT+R LRPL
Sbjct: 129 AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
Query: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
RA+++ M+++V L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
Score = 87.4 bits (215), Expect = 1e-16
Identities = 73/340 (21%), Positives = 140/340 (41%), Gaps = 79/340 (23%)
Query: 112 FGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGI 169
+ ++ R L + +FI G + +N V MA + + + C +FT I
Sbjct: 1553 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1612
Query: 170 YIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP--------- 220
++ E++ K++A GF F +D WN LD ++ ++I+ GIT++ +
Sbjct: 1613 FVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIM----GITLEEIEVNASLPINP 1664
Query: 221 -----LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
+R R+ R LK + + ++ ++ +++++ ++ N+ +L IFA +G +LF
Sbjct: 1665 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1724
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
G+ C + C+
Sbjct: 1725 ------------------------------------------GDLECDETHPCEGLG--- 1739
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRT--------TGLYSVFFFIVVIFLG 387
+ F NFG +FL +FR+ T D+W + + TLR + S +F+ +
Sbjct: 1740 --RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1797
Query: 388 SFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQL 427
F L+N+ +AV+ EE NK E E + ++ E + L
Sbjct: 1798 QFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1837
Score = 86.3 bits (212), Expect = 2e-16
Identities = 66/284 (23%), Positives = 134/284 (47%), Gaps = 28/284 (9%)
Query: 573 VMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKIIA 630
++T + + + I +N + +AME K++ S E++ L + N +FT++F+AEM +K++A
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 631 LD----PYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPT 686
L Y R WN+ D ++ L+S D++ ++ L RVLR+ + +
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 687 ------LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740
L +++ + +S+ +G++ V+ IF ++G+QLF F + N T
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 741 PTVSC------LRHWHMGDFWHSFLVVFRILCGE--WIENMWECMQEANASSS------- 785
+ +RH + D L+ +L + W++ M++ +
Sbjct: 1429 KSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1488
Query: 786 LCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARK 829
++ FI +I VLN+F+ +++ +F ++ R E EAR+
Sbjct: 1489 WMLLYFISFLLIVAFFVLNMFVGVVVENF-HKCRQHQEEEEARR 1531
Score = 85.5 bits (210), Expect = 4e-16
Identities = 56/260 (21%), Positives = 117/260 (45%), Gaps = 52/260 (20%)
Query: 156 SNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT 215
+N +I+ VFT ++ E L+K+L G F ++++P+N D +++ I++ +
Sbjct: 772 TNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQG 827
Query: 216 IKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
L LRTFR+ R LK + + L+ + L++++ + +L + IF+++G LF
Sbjct: 828 GGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Query: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
CK S + + P+ K
Sbjct: 888 -----------GCKFASERDG--------DTLPDRK------------------------ 904
Query: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLT 395
NFD+ W+ + +F+++TQ+ W K+ + +T ++ +FI ++ G++ L NL
Sbjct: 905 -----NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
Query: 396 LAVVTMAYEEQNKNVAAEIE 415
+A++ ++ + +E E
Sbjct: 960 VAILVEGFQAEGDANKSESE 979
Score = 71.2 bits (173), Expect = 8e-12
Identities = 36/118 (30%), Positives = 66/118 (55%), Gaps = 13/118 (11%)
Query: 1224 SQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSL 1283
+ C +G + +NFDN+G A++A+ QV T +GW+DI+Y +D+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1284 GYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGS 1341
+IYF++ II GSFF +NL + VI F++ +++ + M E++ ++ + L S
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425
Score = 56.2 bits (134), Expect = 3e-07
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 554 YLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM----EHHKMEASFEKML 609
YL + P+ C LRTV +P+ E + I++N V L M E ++ ++L
Sbjct: 63 YLSQDSRPRSWC----LRTVC-NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
Query: 610 NIGNLVFTSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSW 666
+ + F EM +K++AL + Y WN D + + + + LQ S+
Sbjct: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEY-SLDLQNVSF 176
Query: 667 PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
+R+ RVLR + P++ L+ ++ +++ LG++ ++ V FIF +VG+QL+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 51.6 bits (122), Expect = 7e-06
Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 1368 FDIIIISLIILNMISMMAESYNQPKAMKS----ILDHLNWVFVVIFTLECLIKIFAL--- 1420
F+ I + +I+LN +++ + A S IL + F +E ++K+ AL
Sbjct: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
Query: 1421 -RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
++ Y + WN D +V+ ++ + L+N F VR R+ R LR +
Sbjct: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD-LQNVS--------FSAVRTVRVLRPLRAINR 193
Query: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
+R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 194 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 230
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
++++ +F+++ E W++ M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 398
Query: 815 S-NEERNGNLEGEAR 828
S ++R L E R
Sbjct: 399 SETKQRESQLMREQR 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,038,494
Number of Sequences: 37866
Number of extensions: 2932155
Number of successful extensions: 15423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 10963
Number of HSP's gapped (non-prelim): 1597
length of query: 1791
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1674
effective length of database: 13,817,196
effective search space: 23129986104
effective search space used: 23129986104
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.