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Search of human proteins with 115529478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
(761 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 1529 0.0
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 1391 0.0
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 1383 0.0
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 566 e-161
gi|118572606 hemicentin 1 [Homo sapiens] 167 3e-41
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 162 1e-39
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 162 1e-39
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 155 2e-37
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 154 2e-37
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 154 2e-37
gi|19743806 roundabout 1 isoform b [Homo sapiens] 154 4e-37
gi|4506569 roundabout 1 isoform a [Homo sapiens] 154 4e-37
gi|224994173 roundabout 1 isoform d [Homo sapiens] 150 6e-36
gi|224994171 roundabout 1 isoform c [Homo sapiens] 150 6e-36
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 150 6e-36
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 150 6e-36
gi|110349719 titin isoform N2-A [Homo sapiens] 145 1e-34
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 144 2e-34
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 142 9e-34
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 140 4e-33
gi|109150416 peroxidasin [Homo sapiens] 140 6e-33
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 138 2e-32
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 135 1e-31
gi|222352127 sidekick 2 [Homo sapiens] 132 9e-31
gi|157311649 neogenin homolog 1 [Homo sapiens] 132 1e-30
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 129 8e-30
gi|15147240 brother of CDO [Homo sapiens] 127 3e-29
gi|139948432 adlican [Homo sapiens] 127 5e-29
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 126 7e-29
gi|119220552 sidekick 1 [Homo sapiens] 125 1e-28
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 1529 bits (3958), Expect = 0.0
Identities = 761/761 (100%), Positives = 761/761 (100%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN
Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
Query: 601 PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ 660
PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ
Sbjct: 601 PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ 660
Query: 661 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 720
DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA
Sbjct: 661 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 720
Query: 721 AHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLLC 761
AHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLLC
Sbjct: 721 AHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLLC 761
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 1391 bits (3600), Expect = 0.0
Identities = 707/762 (92%), Positives = 710/762 (93%), Gaps = 37/762 (4%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN
Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV-- 598
Query: 601 PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ 660
+GEPSAPKLEGQMGEDGNSIKVNLIKQ
Sbjct: 599 ---------------------------------QGEPSAPKLEGQMGEDGNSIKVNLIKQ 625
Query: 661 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 720
DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA
Sbjct: 626 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
Query: 721 AHFVFRTSAQPTAIPATLGGNSASYT--FVSLLFSAVTLLLL 760
AHFVFRTSAQPTAIPA S T V +L LLL+
Sbjct: 686 AHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 727
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 1383 bits (3579), Expect = 0.0
Identities = 707/772 (91%), Positives = 710/772 (91%), Gaps = 47/772 (6%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK------- 353
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
Query: 354 ---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 410
TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
Sbjct: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420
Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
Sbjct: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
Query: 591 SEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDG 650
SEFKTQPV +GEPSAPKLEGQMGEDG
Sbjct: 601 SEFKTQPV-----------------------------------QGEPSAPKLEGQMGEDG 625
Query: 651 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 710
NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV
Sbjct: 626 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 685
Query: 711 AENQQGKSKAAHFVFRTSAQPTAIPATLGGNSASYT--FVSLLFSAVTLLLL 760
AENQQGKSKAAHFVFRTSAQPTAIPA S T V +L LLL+
Sbjct: 686 AENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 737
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 566 bits (1459), Expect = e-161
Identities = 313/765 (40%), Positives = 448/765 (58%), Gaps = 61/765 (7%)
Query: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK
Sbjct: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
+ Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+
Sbjct: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
+PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K
Sbjct: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178
Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
+DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P
Sbjct: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE +
Sbjct: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KTLDGHM 359
L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + + E K+LDG +
Sbjct: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWE 418
V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK + Y+WE
Sbjct: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
GN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S+NDFG YN
Sbjct: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
CTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVPI Y+ +
Sbjct: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+ V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S F+T P
Sbjct: 535 KEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
Query: 598 VHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL 657
V P PP+ G+PS+ G S K+++
Sbjct: 591 VREPSPPS---------------------------IHGQPSS----------GKSFKLSI 613
Query: 658 IKQDDGGSPIRHYLVRYRALSSE--WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 715
KQDDGG+PI Y+V+YR+ E W E ++ DH++L+ L W YEV + A N+
Sbjct: 614 TKQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQGNKDHIILEHLQWTMGYEVQITAANRL 672
Query: 716 GKSKAAHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAVTLLLL 760
G S+ + F +P I TL + L +A+ L+L+
Sbjct: 673 GYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILV 717
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 167 bits (424), Expect = 3e-41
Identities = 127/428 (29%), Positives = 189/428 (44%), Gaps = 25/428 (5%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGED 134
++ S L I +A + D G Y C T G +E VN+ + + + T EG
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNL 2213
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS-NNYLQIRGIKKTDEGTYRCEGRI 193
++C+ PP +IWK KG V+ R +LS LQI +K+D Y C
Sbjct: 2214 ISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASN 2273
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
+A ++QV + P + + G+S++L C+ +G P PT++W KDG
Sbjct: 2274 VAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP 2332
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--- 310
+ + + E D+ L +K + +D Y+C+A N AG D L V A P I
Sbjct: 2333 LIKAKGVE---ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN 2389
Query: 311 -TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
EN + +E + V+LTCEASG P+PSITW +S L + + S R+
Sbjct: 2390 HRSPENISVVE-KNSVSLTCEASGIPLPSITWFKDGWPVS-----LSNSVRILSGGRM-- 2441
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITC 426
L L DAG+Y C N G++ + L V P + G V E V +TC
Sbjct: 2442 LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
EV P I+W +DGQ L +I +L++T G Y C A + G
Sbjct: 2502 EVTGNPVPEITWHKDGQPLQEDEAHHI----ISGGRFLQITNVQVPHTGRYTCLASSPAG 2557
Query: 487 QESLEFIL 494
+S F L
Sbjct: 2558 HKSRSFSL 2565
Score = 160 bits (404), Expect = 5e-39
Identities = 121/473 (25%), Positives = 197/473 (41%), Gaps = 61/473 (12%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-V 110
I+WF N RI L + ++DAG Y CVV G E + +
Sbjct: 2418 ITWFKDGWPVSLSNSVRIL-----SGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+V + ++ +N + +E + + C+V + P I W HK + + + I+
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW-HKDGQPLQEDEAHHIISG 2531
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQ---ARQNIVNATA 225
+LQI ++ G Y C LA K +NV PTI + N + T
Sbjct: 2532 GRFLQITNVQVPHTGRYTC----LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
L +LVC+A +P T++W KDG +E + L I +++ Y
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIR---ILPGGRTLQILNAQEDNAGRY 2644
Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIP 337
C+A N+AGE +KV+ P I + + +++ +TL CEA P
Sbjct: 2645 SCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
S++W + + S D H+ + ++ +L +K Q +D G Y C ASN G+D
Sbjct: 2705 SLSWYKDGQPLKS-----DDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAGEDELD 2757
Query: 398 MYLEVQYAPKLQGPVAVYTWE------------------GNQVNITCEVFAYPSATISWF 439
+ +Q P Q WE N +++ CE A P T++W+
Sbjct: 2758 FDVNIQVPPSFQ-----KLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+DG L SS+ K+ P L++ D G Y C AVN G++SL++
Sbjct: 2813 KDGHPLTSSD----KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQY 2861
Score = 158 bits (399), Expect = 2e-38
Identities = 114/420 (27%), Positives = 183/420 (43%), Gaps = 33/420 (7%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L + +A I D G Y CV G E + ++++++ + ++C
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAG-EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ 2126
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ PPT+ W G +LKK I + + L+I + D G Y CE +A G+
Sbjct: 2127 SDAIPPPTLTWLKDGHP-LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA-GKTE 2184
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K+ V + VPP I + T G ++L+C++ G P P + W K G + +
Sbjct: 2185 -KNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG 2243
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV---ENQT 317
I S QL I +K+D A Y C+A N AG +L+V+ +P IT +
Sbjct: 2244 RVRILS-GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-----RVSSLTL 372
+ + ++L CE G P P++TW DGH ++++ L L
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMK------------DGHPLIKAKGVEILDEGHILQL 2350
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEV 428
K+I +D G Y+C A N G + L V P + G P + E N V++TCE
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
P +I+WF+DG P S ++++I + L + + D G Y C N G+E
Sbjct: 2411 SGIPLPSITWFKDG--WPVSLSNSVRILS--GGRMLRLMQTTMEDAGQYTCVVRNAAGEE 2466
Score = 155 bits (393), Expect = 1e-37
Identities = 141/515 (27%), Positives = 215/515 (41%), Gaps = 47/515 (9%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A +DAG Y CV G+ A +K+ ++ +P +E+ D I
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT---ALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 138 V--CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
C+ PP I W GR ++ + +R VLS+ LQI ++ D G Y C +A
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
++ V+VPP I++ + + T N L C A+G P P ++W KD +
Sbjct: 4155 GSSST--STKLTVHVPPRIRSTEG--HYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
KY ++ +L ++ V D Y C+A N AGE T+ L V P T +
Sbjct: 4211 NLLG--KYT-AEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG 4267
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
++ EQ+ L+C+A+G P+P +TW + I + +++GH S L ++ +
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH---------SELVIERV 4318
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPS 433
D+G Y+CTA N++G ++ V+ P +G E G + CEV P+
Sbjct: 4319 SKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
TI W R G + S+ ++ N A Y V D+ G+Y C A N G
Sbjct: 4379 PTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDA----GDYTCVATNEAGVVERSMS 4433
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW----HS-K 548
L T SP I +EP + GG IL +A W HS
Sbjct: 4434 L----TLQSPPIITLEPVETVIN--------AGGKIILNCQATGEPQPTITWSRQGHSIS 4481
Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
W D + I + E T A N G
Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 154 bits (388), Expect = 4e-37
Identities = 134/494 (27%), Positives = 214/494 (43%), Gaps = 54/494 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P + +I V + C+ A +SW+ +G+ L + +++ N TL I
Sbjct: 2681 PKEVKIKVNNTLTLECE-AYAIPSASLSWYK-DGQPLK-SDDHVNIAAN---GHTLQIKE 2734
Query: 86 ANIDDAGIYKCV---VTGEDGSESEATVNVKI---FQKLM-FKNAPTPQEFREGEDAVI- 137
A I D G Y CV + GED E + VN+++ FQKL N E +D +I
Sbjct: 2735 AQISDTGRYTCVASNIAGED--ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIIN 2792
Query: 138 -----VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR 192
C+ ++ PPT+ W G + D I+ LQI K D G Y C
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHP-LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA- 2850
Query: 193 ILARGEINFK-DIQVIVNVPPTIQARQNIV--NATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ GE + + D++V+V PP I+ + + T + +S + C + G P P SW K
Sbjct: 2851 VNEAGEDSLQYDVRVLV--PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
DG+ + + D+ + F + L I D Y+C+AEN AG +L V P
Sbjct: 2909 DGQPLLE---DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965
Query: 310 ITYVENQT-AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL---DGHMVVRSHA 365
+ +++ + + ++LTCE SG P P ++W + + I TL G + A
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-----QGPVAVYTWEGN 420
+VS D GEY C A N G+ + L V P + + V EG
Sbjct: 3026 KVS----------DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
V++ CE A P I+W+++G+++ S + I L + +D G Y C
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEI----LADGQMLHIKKAEVSDTGQYVCR 3131
Query: 481 AVNRIGQESLEFIL 494
A+N G++ F L
Sbjct: 3132 AINVAGRDDKNFHL 3145
Score = 153 bits (387), Expect = 5e-37
Identities = 132/477 (27%), Positives = 206/477 (43%), Gaps = 34/477 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P ++ + S C+ AG+ ++W + RI L I +
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPI-LTWLKDGVPVKANDNIRIEA-----GGKKLEIMS 1701
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV--CDVVS 143
A D G Y CV T G E E V + + F + ++ C V
Sbjct: 1702 AQEIDRGQYICVATSVAG-EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
S PPTI+W G+ +I ++D I+L+ L I + ++ G YRC A + K+
Sbjct: 1761 SPPPTIMWLKDGQ-LIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD--HKKE 1817
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+V V+VPPTI++ + + V L C A G P P+++W KD + + + + K
Sbjct: 1818 FEVTVHVPPTIKS-SGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK- 1875
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT---YVENQTAME 320
L I K D Y C+A N AGE I L V P + + N+T +
Sbjct: 1876 -IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVL- 1933
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
+ V L C+A+G+P+P ITW R +S M + ++ + ++S Q +DA
Sbjct: 1934 VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTS-----MTFLNRGQI--IDIESAQISDA 1986
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437
G Y C A N+ G L+V AP + G VAV N V + CE P+ +++
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVV--NNPVRLECEARGIPAPSLT 2044
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
W +DG P S++SN + L +T +D G Y C AVN G++ + L
Sbjct: 2045 WLKDGS--PVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDL 2098
Score = 152 bits (385), Expect = 9e-37
Identities = 120/476 (25%), Positives = 190/476 (39%), Gaps = 30/476 (6%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P ++ VG+ C G I+W L + +S + TL+I
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVS-----NPDGTLSIDQ 1230
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE---GEDAVIVCDV 141
A DAGIY CV T G+ E+E T++V+ + P F+E + C
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPA 1290
Query: 142 VSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF 201
+ PTI W H GR++ ++ I+ L I + D G Y C +
Sbjct: 1291 KGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA--VNEAGTTE 1348
Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+ + V+VPP I+ ++ + N + L Q L C+ EG P P + W KD Q+ + +
Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQ 1408
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAM 319
++ L + + D Y C A N AG ++ V P I T N+ ++
Sbjct: 1409 TV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
L V L C+ G P P I W + G V R L LK+ + D
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHW------FKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATI 436
G Y CT SN G+ ++ + L + P ++G + + + + CE P I
Sbjct: 1520 KGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAI 1579
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+W++DGQ + SS+ + +Y YL + +D Y C N G F
Sbjct: 1580 TWYKDGQPIMSSSQA---LY-IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Score = 151 bits (382), Expect = 2e-36
Identities = 155/646 (23%), Positives = 261/646 (40%), Gaps = 63/646 (9%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+WF +G L N+ I ++ TL I NA D+AG Y CV T E G E
Sbjct: 2607 ITWFK-DGTPLESNRN-IRIL---PGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYE 2660
Query: 112 VKIFQKLMFKN--------APTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKD 163
VK++ + +P + + + C+ + ++ W G+ LK D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP--LKSD 2718
Query: 164 VRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN 222
+ +N + LQI+ + +D G Y C +A GE D V + VPP+ Q I N
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIA-GEDEL-DFDVNIQVPPSFQKLWEIGN 2776
Query: 223 A--TANLGQS--------VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQL 272
T G++ ++L C+ P PT++W KDG + + K + L
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSD---KVLILPGGRVL 2833
Query: 273 TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL----EEQVTLT 328
I + D Y C+A N+AGE ++V P I + E+ + +
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE 2893
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
C +SG P P +W+ + + D H S+ R+ L + + Q TD G Y+C A
Sbjct: 2894 CLSSGSPAPRNSWQKDGQPLLE-----DDHHKFLSNGRI--LQILNTQITDIGRYVCVAE 2946
Query: 389 NTIGQDSQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
NT G + L V P + GP + + N +++TCEV +P +SW ++ Q +
Sbjct: 2947 NTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS----- 501
+ + I P L++ +D G Y C A+N+ G+ +F L PS
Sbjct: 3007 LNTNTLI----VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHD 3062
Query: 502 SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561
S S+ V T+ V + P++ + R + E D + ++
Sbjct: 3063 SESLSVVNVREGTS-VSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ------ML 3115
Query: 562 TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VHSPPPPASASS-STPVPLSPPD 619
I + T A+N G + + P + P + S PV L+
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDA 3175
Query: 620 TTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGS 665
T P P +A + K ++ LE ++ G+ +++ + D G+
Sbjct: 3176 TGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGN 3221
Score = 150 bits (378), Expect = 6e-36
Identities = 133/501 (26%), Positives = 206/501 (41%), Gaps = 52/501 (10%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+W+ NG +T + + ++ + L I A + D G Y C G +
Sbjct: 3091 ITWYK-NGRMITESTH-VEILAD---GQMLHIKKAEVSDTGQYVCRAINVAGRDD----- 3140
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIV----------CDVVSSLPPTIIW--KHKGRDVI 159
K N P E VIV CD PPTI W HK +
Sbjct: 3141 -----KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENS 3195
Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN 219
+VR I+ + LQI + +D G Y C + G+ K + + VPP++ +
Sbjct: 3196 DSLEVR-ILSGGSKLQIARSQHSDSGNYTCIASNM-EGKAQ-KYYFLSIQVPPSVAGAEI 3252
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
+ + LG++V LVC+A G P P + W KDG+ I E E+ S + S L I
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE-TERIRVSANGSTLNIYGALT 3311
Query: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAMEL-EEQVTLTCEASGDPI 336
+D +Y C+A N AGE+D +L V+ P I E + M L + + + C A+G P
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 337 PSITWRTS--TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
P I W + +SS + L V+R + Q +D Y C ASN G D
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIR---------IVRAQVSDVAVYTCVASNRAGVD 3422
Query: 395 SQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
++ L+V P + G + +G+ ++ C P+ +++W RDGQ L +
Sbjct: 3423 NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL 3482
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
+ + L++ D G Y C A N G+ S FIL + P ++ E
Sbjct: 3483 TVSTH----GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI 3538
Query: 512 SSTAQVQFDEPEATGGVPILK 532
S + G+P K
Sbjct: 3539 SVIVNNPLELTCIASGIPAPK 3559
Score = 148 bits (373), Expect = 2e-35
Identities = 125/483 (25%), Positives = 201/483 (41%), Gaps = 39/483 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G+S C+V G ++W + I D L + N
Sbjct: 2299 PTEIIVTRGKSISLECEVQG-IPPPTVTWMKDGHPLIKAKGVEIL-----DEGHILQLKN 2352
Query: 86 ANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKN-APTPQEFREGEDAVIVCDVVS 143
++ D G Y CV G ++ + ++V ++ + +P E + C+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
P+I W G V L VR I+ L++ D G Y C R A E
Sbjct: 2413 IPLPSITWFKDGWPVSLSNSVR-ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+ V+V PP I + + QSVTL C+ G P P ++W KDG+ + +ED+ +
Sbjct: 2472 LSVLV--PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPL--QEDEAHH 2527
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--- 320
I S L I V Y C+A + AG + + L VF P I V + E
Sbjct: 2528 IIS-GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 321 --LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
L +L CEA P +ITW + L+ + +R +L + + Q
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITW-------FKDGTPLESNRNIRILPGGRTLQILNAQED 2639
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------GPVAVYTWEGNQVNITCEVF 429
+AG Y C A+N G+ + ++V P + P V N + + CE +
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
A PSA++SW++DGQ L S ++ NI + L++ +D G Y C A N G++
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNI----AANGHTLQIKEAQISDTGRYTCVASNIAGEDE 2755
Query: 490 LEF 492
L+F
Sbjct: 2756 LDF 2758
Score = 144 bits (364), Expect = 2e-34
Identities = 118/473 (24%), Positives = 202/473 (42%), Gaps = 41/473 (8%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+ AG+ I+W+ N +L ++ + + + I +A I DAGIYKCV
Sbjct: 1942 CKAAGNPVPV-ITWYKDN--RLLSGSTSMTFL---NRGQIIDIESAQISDAGIYKCVAIN 1995
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI------VCDVVSSLPPTIIWKHK 154
G+ ++F L AP+ V+ C+ P++ W
Sbjct: 1996 SAGA-------TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048
Query: 155 GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTI 214
G V + ++ L + + +D G Y C + A GE +DI + V VPP I
Sbjct: 2049 GSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQ-RDIDLRVYVPPNI 2106
Query: 215 QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI 274
+ N + + Q+V L+C ++ P PT++W KDG + ++ S++ S L I
Sbjct: 2107 MGEEQ--NVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG---LSISENRSVLKI 2161
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ--VTLTCEAS 332
+ D Y C A N AG+ + ++ ++ P I + T + + E ++L CE+S
Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESS 2221
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P++ W+ + ++ G + + S R L + + +DA Y C ASN G
Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSM---GRVRILSGGR--QLQISIAEKSDAALYSCVASNVAG 2276
Query: 393 QDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448
+ L+V P + P + G +++ CEV P T++W +DG P
Sbjct: 2277 TAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGH--PLI 2334
Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
++I + L++ +D G Y C AVN G ++ L PS
Sbjct: 2335 KAKGVEILD--EGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385
Score = 144 bits (362), Expect = 4e-34
Identities = 103/414 (24%), Positives = 175/414 (42%), Gaps = 17/414 (4%)
Query: 75 DDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGED 134
+ +S L I + D G Y+C+ G+ A + + P GE
Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGT-GRAQTFFDVSEPPPVIQVPNNVTVTPGER 536
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
AV+ C ++S++ + W+ RDV L + R L+N L+++ +K D G Y C +
Sbjct: 537 AVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHC--MVS 594
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
+ G + + + V PP + N + G V+++C A G+P+P ++WT + I
Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPK--NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI 652
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
+Y + D + L IK D Y C+A N AG L+ PK+ V+
Sbjct: 653 ---VGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
++ + L + + C+ SG P P + W + + + + L ++
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPL-------LGLLKIQE 761
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPS 433
Q DAG+Y C A N G+ + + L+V P +Q P V G+ V + C V YP
Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPE 821
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
TI W R + S ++ + L + +D G Y C A N+ G+
Sbjct: 822 PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK 875
Score = 142 bits (357), Expect = 2e-33
Identities = 122/454 (26%), Positives = 183/454 (40%), Gaps = 32/454 (7%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139
L I A ++D G Y C+ + G + E V V + + + P + C
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643
Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
+ PP I W G + VR I+ YLQI D Y C +A G+
Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTANYTCVASNIA-GKT 3701
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
++ + VNVPP I+ + L +S L C AEG P P ++W KDG +
Sbjct: 3702 T-REFILTVNVPPNIKGGPQ--SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+ ++ L I+ D Y+C+A N AG I L+V P I +
Sbjct: 3759 RYSIL---ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV 3815
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ Q TL CEA+G P PSI WR ++ + ++ + + ++ S SL + S D
Sbjct: 3816 IVNVQTTLACEATGIPKPSINWR-KNGHLLNVDQNQNSYRLLSS----GSLVIISPSVDD 3870
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISW 438
Y CT +N G D +++ L VQ P + P + ITC P +I W
Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHW 3930
Query: 439 FRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
++G +LLP + Y S+ +E+ N G Y C A N G L
Sbjct: 3931 TKNGIRLLPRGDG-----YRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVH 3985
Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEP-----EATG 526
+ P ++P S V + P EATG
Sbjct: 3986 EPP------VIQPQPSELHVILNNPILLPCEATG 4013
Score = 140 bits (353), Expect = 4e-33
Identities = 115/412 (27%), Positives = 174/412 (42%), Gaps = 24/412 (5%)
Query: 81 LTIYNANIDDAGIYKCVVT---GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
L I A + + G+Y+C+ G+ E E TV+V K++ + V
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP----TIKSSGLSERVVVKYKPVA 1845
Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
+ + + +P P+I W + V + I S LQI D G Y C A
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA- 1904
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GE + IQ+ V+ PP+++ ++N T + V L C A G P P ++W KD +
Sbjct: 1905 GETQ-QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS- 1962
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
F + + I+ +D Y C+A N AG + L+V P I+ N
Sbjct: 1963 --GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
A+ + V L CEA G P PS+TW +SS L V S R+ +LT S Q
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ----VLSGGRILALT--SAQ 2074
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSAT 435
+D G Y C A N G+ + + L V P + G V V + C+ A P T
Sbjct: 2075 ISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPT 2134
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
++W +DG L +I + + S L++ D G Y C A N G+
Sbjct: 2135 LTWLKDGHPLLKKPGLSI----SENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Score = 139 bits (350), Expect = 1e-32
Identities = 130/478 (27%), Positives = 197/478 (41%), Gaps = 41/478 (8%)
Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
+V S+ +++G+ C+ +G + WF + E L P+ I D L I
Sbjct: 706 VVQSELLVALGDITVMECKTSG-IPPPQVKWFKGDLE-LRPSTFLII----DPLLGLLKI 759
Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVS 143
DAG Y CV E G + + + + +F P G + + C V
Sbjct: 760 QETQDLDAGDYTCVAINEAG-RATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG 818
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEIN 200
PTI W+ I + +S L I + +D+GTY CE A +
Sbjct: 819 YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICE----AENQFG 874
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDA-EGFPEPTMSWTKDGEQIEQE 257
+ V V + I + AN+ GQ +TL C G P P W K+ + Q
Sbjct: 875 KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
YI L I++V D EY C+A N AG + T + V P I + +
Sbjct: 935 P----YITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
+ VTL C+ASG+P PS+ W IS+ S SL + S
Sbjct: 991 STIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF-------SAGADGSLYVVSPGG 1043
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---------PVAVYTWEGNQVNITCEV 428
++GEY+CTA+NT G + + L V P++ G PV + G +V + CEV
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103
Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+ P I+W ++ QL+ S +S + PS S +++T +D G Y C A N G
Sbjct: 1104 KSLPPPIITWAKETQLI--SPFSPRHTF-LPSGS-MKITETRTSDSGMYLCVATNIAG 1157
Score = 139 bits (349), Expect = 1e-32
Identities = 119/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+W+ +G+ + + Q + + D L I A + D+ Y C V G+ +E + +
Sbjct: 1579 ITWYK-DGQPIMSSSQALYI----DKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSFH 1632
Query: 112 VKIFQKLMFK-NAPTP--QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
V ++ M + N TP ++ + C + P + W G V ++R I
Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-IE 1691
Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
L+I ++ D G Y C +A GE K +V V VPP I+ +
Sbjct: 1692 AGGKKLEIMSAQEIDRGQYICVATSVA-GEKEIK-YEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
+ L C G P PT+ W KDG+ I+ E D K + + +L I + ++ Y C+
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLID-ERDGFKILL--NGRKLVIAQAQVSNTGLYRCM 1806
Query: 289 AENKAGEQDATIHLKVFAKPKI-TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
A N AG+ + V P I + ++ + + V L C A+G P PSITW +
Sbjct: 1807 AANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQP 1866
Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK 407
++ T G++ ++S RV L + DAG Y C A+N G+ Q + L V P
Sbjct: 1867 VN----TAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 408 LQGPVAVY---TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
L+ + N V + C+ P I+W++D +LL S +++ N +
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS--TSMTFLN--RGQII 1976
Query: 465 EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
++ +D G Y C A+N G L + L PS
Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 138 bits (348), Expect = 2e-32
Identities = 115/435 (26%), Positives = 184/435 (42%), Gaps = 30/435 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-VNVKIFQKLMFKNAPTPQEFREGEDAV 136
S ++ I D+G+Y CV T G+ ++A +NV + K+ + P + + G+
Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI--QRGPKHLKVQVGQRVD 1189
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I C+ + P I W KG +L + + L I +D G Y C +A
Sbjct: 1190 IPCNAQGTPLPVITWS-KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAG 1248
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATAN---LGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
+ +I + V PPT++ + N T Q + C A+G P+PT+ W +G +
Sbjct: 1249 TDET--EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRE 1306
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
+ E + +D + L I V D EYIC+A N+AG + +LKV P I
Sbjct: 1307 LTGREPGISIL--EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDK 1364
Query: 314 ENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI--SSEEKTLDGHMVVRSHARVSS 369
E T + L + L CE G P P I W + SS +T++ +++
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPE 1424
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITC 426
DAG Y C A N G + ++V P + G P V V + C
Sbjct: 1425 ---------DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALEC 1475
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+V P I WF+DG+ L + N+++ + +L+ ND G Y CT N G
Sbjct: 1476 QVKGTPFPDIHWFKDGKPLFLGD-PNVELLDRGQVLHLKNA--RRNDKGRYQCTVSNAAG 1532
Query: 487 QESLEFILVQADTPS 501
+++ + L PS
Sbjct: 1533 KQAKDIKLTIYIPPS 1547
Score = 135 bits (340), Expect = 1e-31
Identities = 117/480 (24%), Positives = 195/480 (40%), Gaps = 28/480 (5%)
Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
F L V + P I + +S C +A I+W +G L N R S+
Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITW-RKDGAVLAGNHARYSI 3762
Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE 131
+ N L I +A++ D G Y C+ T G++ +++++ PT
Sbjct: 3763 LEN----GFLHIQSAHVTDTGRYLCMATNAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIV 3817
Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCE 190
+ C+ P+I W+ G + + ++ + +LS+ L I D TY C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+ + + + + V VPP+I T + +T C A G P P++ WTK+
Sbjct: 3878 --VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSIHWTKN 3933
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
G ++ D + + S + I N Y C+A N AG + L V P I
Sbjct: 3934 GIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVI 3990
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
++ + L + L CEA+G P P ITW+ N+++ + H V+ S L
Sbjct: 3991 QPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGR---NHAVLPS----GGL 4043
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQ-VNITCEVF 429
+ DAG Y+C A N G + L VQ P + + Y ++ + ++CE
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEAD 4103
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P I+W +DG+ + S + S+ L++ D G+Y C A N G S
Sbjct: 4104 GLPPPDITWHKDGRAIVESIRQRVL-----SSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Score = 129 bits (323), Expect = 1e-29
Identities = 126/562 (22%), Positives = 217/562 (38%), Gaps = 30/562 (5%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGED 134
+ + I A + D +Y CV + G +++ N+++F N+ +E +G
Sbjct: 3394 AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH-YNLQVFAPPNMDNSMGTEEITVLKGSS 3452
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRI 193
+ C + P++ W G+ + L D V ++ LQ+ + D G Y C
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGL--DAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
A GE++ K + V PP I + + + + L C A G P P M+W KDG
Sbjct: 3511 EA-GEVS-KHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP 3568
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
+ Q + + L I D Y C+A + AG+ D ++V P I
Sbjct: 3569 LPQTDQVQTL---GGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT 3625
Query: 314 ENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
+ + + QVTL C++ P P ITW + + + + VR + L
Sbjct: 3626 DEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR-------VRILSGGRYLQ 3678
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA 430
+ + D Y C ASN G+ ++ L V P ++ GP ++ + C
Sbjct: 3679 INNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEG 3738
Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
P+ I+W +DG +L + N++ Y+ +L + D G Y C A N G +
Sbjct: 3739 VPTPRITWRKDGAVL-AGNHAR---YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRR 3794
Query: 491 EFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
I +Q P PSI P + T V A I K WR G + +
Sbjct: 3795 R-IDLQVHVP--PSI-APGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ 3850
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VHSPPPPASASS 609
++ G + I+ + T NG G + + + P + P +
Sbjct: 3851 NSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTK 3910
Query: 610 STPVPLSPPDTTWPLPALATTE 631
P ++ + P P++ T+
Sbjct: 3911 HAPAVITCTASGVPFPSIHWTK 3932
Score = 124 bits (312), Expect = 2e-28
Identities = 115/473 (24%), Positives = 186/473 (39%), Gaps = 32/473 (6%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
S +L I + D G Y CV + G+ ++ T +V + ++ EG
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIEGIPVT 999
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
+ C + P++IW KG ++I +F ++ L + + G Y C A
Sbjct: 1000 LPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA- 1057
Query: 197 GEINFKDIQVIVNVPPTIQARQN------IVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G K +Q+ V V P + Q V + G+ VTL C+ + P P ++W K+
Sbjct: 1058 GYAKRK-VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
+ I ++ S + I + +D Y+C+A N AG + L V PKI
Sbjct: 1117 TQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
+++ ++V + C A G P+P ITW + +DG V + +L
Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVITW-----SKGGSTMLVDGEHHVSNPD--GTL 1226
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNI 424
++ +DAG Y C A+N G D + L VQ P ++ Y ++
Sbjct: 1227 SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF 1286
Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
C P TI W +G+ L + I I + L + + D G Y C AVN
Sbjct: 1287 PCPAKGTPKPTIKWLHNGREL-TGREPGISILE--DGTLLVIASVTPYDNGEYICVAVNE 1343
Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYS---STAQVQFDEPEATGGVPILKYK 534
G ++ L P +QV S + F E E T I+ YK
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Score = 121 bits (303), Expect = 3e-27
Identities = 116/442 (26%), Positives = 178/442 (40%), Gaps = 40/442 (9%)
Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
DI+W + +QR+ SS +L I DAG Y C+ GS S +T
Sbjct: 4109 DITWHKDGRAIVESIRQRVL------SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST- 4161
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDV--RFI 167
+ + ++ E A++ C V +P P I WK +D +L ++ ++
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWK---KDNVLLANLLGKYT 4217
Query: 168 VLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL 227
L + + D G Y C A GE + + + V+V PT + + N
Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVAN-NAAGE-DTHTVSLTVHVLPTFTELPG--DVSLNK 4273
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G+ + L C A G P P ++WT + I D + S+L I++V K D Y+C
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS-----VNGHSELVIERVSKEDSGTYVC 4328
Query: 288 IAENKAGEQDATIHLKVFAKP--KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
AEN G A + V P K Y N L L CE GDP P+I W
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIE-PLGGNAILNCEVKGDPTPTIQWNRKG 4387
Query: 346 RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405
+I + +R SL + DAG+Y C A+N G +SM L +Q
Sbjct: 4388 VDIEISHR-------IRQLGN-GSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP 4439
Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
P + PV G ++ + C+ P TI+W R G + + N+ N+ L
Sbjct: 4440 PIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS-----L 4494
Query: 465 EVTPDSENDFGNYNCTAVNRIG 486
+ + D + C A N +G
Sbjct: 4495 YIADAQKEDTSEFECVARNLMG 4516
Score = 120 bits (302), Expect = 4e-27
Identities = 114/466 (24%), Positives = 184/466 (39%), Gaps = 27/466 (5%)
Query: 25 VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIY 84
VP+ ++ GE C + A D +++W + + RI + N +L +
Sbjct: 525 VPNNVTVTPGERAVLTCLIIS-AVDYNLTWQRNDRDVRLAEPARIRTLAN----LSLELK 579
Query: 85 NANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ +DAG Y C+V+ E GS S A+V + + + P Q F G + I+C
Sbjct: 580 SVKFNDAGEYHCMVSSEGGS-SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGY 638
Query: 145 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P I W D+ + R+ + S+ L I+ D G Y C A + +
Sbjct: 639 PKPKIAWTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
+ I P + + ++ A LG + C G P P + W K ++ I
Sbjct: 697 RYI-EAPKLMVVQSELLVA---LGDITVMECKTSGIPPPQVKWFKGDLELRPSTF---LI 749
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
L I++ D +Y C+A N+AG I L V + P +ME+
Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSN 809
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
VTL C G P P+I WR N+ + + S R +L + ++ +D G YI
Sbjct: 810 VTLPCYVQGYPEPTIKWR-RLDNMPIFSRPFSVSSI--SQLRTGALFILNLWASDKGTYI 866
Query: 385 CTASNTIG--QDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA-YPSATISWFR 440
C A N G Q ++ + AP + P EG Q+ + C + A P W +
Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK 926
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+ +L + Y ++ S L + D G Y C A N G
Sbjct: 927 NSAMLLQNPYITVR-----SDGSLHIERVQLQDGGEYTCVASNVAG 967
Score = 111 bits (277), Expect = 3e-24
Identities = 100/372 (26%), Positives = 159/372 (42%), Gaps = 35/372 (9%)
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I C V S LP T+ + G V L D ++ L I + +DEG Y C + +
Sbjct: 449 IPCSVDSLLPFTLSFVRNG--VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIA-VSSA 505
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
G + + PP IQ N+ T G+ L C + ++W ++ +
Sbjct: 506 GTGRAQTFFDVSEPPPVIQVPNNV---TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E ++ S L +K V ND EY C+ ++ G A++ L V PK+T +
Sbjct: 563 AEPARIRTLANLS--LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKN 620
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-RVSS---LTL 372
+ +V++ C A+G P P I W T++ +V SH R++S L +
Sbjct: 621 QSFTGGSEVSIMCSATGYPKPKIAW------------TVNDMFIVGSHRYRMTSDGTLFI 668
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVF 429
K+ DAG Y C ASN+ G D Q+ L APKL Q + V G+ + C+
Sbjct: 669 KNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVAL--GDITVMECKTS 726
Query: 430 AYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
P + WF+ D +L PS+ + P L++ + D G+Y C A+N G+
Sbjct: 727 GIPPPQVKWFKGDLELRPST-----FLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 781
Query: 489 SLEFILVQADTP 500
+ + L P
Sbjct: 782 TGKITLDVGSPP 793
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 162 bits (410), Expect = 1e-39
Identities = 180/717 (25%), Positives = 277/717 (38%), Gaps = 86/717 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ +GE++ P R+ +
Sbjct: 53 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 110
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
+ + D G Y CV G ++++ + F+ PT GE A++ C
Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170
Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
P PTI WK K + I K+ R I + L I +K+D G Y C G + GE
Sbjct: 171 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 227
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ ++ V PT R +N ++V C +G P+PT+ W KD + +
Sbjct: 228 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 285
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+
Sbjct: 286 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 340
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373
+ VT CE G+P P++ W+ + L + + ++R S LT+
Sbjct: 341 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 395
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
+IQ +DAG YIC A G LEV LQGP + C
Sbjct: 396 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 455
Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
+ P ISW ++G P + + I+ T L + +D G Y C A +
Sbjct: 456 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 510
Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
G+ S +L +D P PS QV + + +P G +P
Sbjct: 511 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 570
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+
Sbjct: 571 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 627
Query: 593 -FKTQPVHSPPP-------------PASASSSTPVPLSPP--DTTWPLP----------- 625
+TQ + SPP PV L+P TW +
Sbjct: 628 PVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRV 686
Query: 626 ALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWK 682
T + S L+ ++ + +++ VNL K +R Y ++ + SE K
Sbjct: 687 MYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK 743
Score = 53.9 bits (128), Expect = 5e-07
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ S++ LEV Q P V G
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 166
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TI W +D ++ I I L ++ ++D G Y C
Sbjct: 167 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 221
Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525
N +G+ + E + + T I+QV E QVQ D P+ T
Sbjct: 222 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 271
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 162 bits (410), Expect = 1e-39
Identities = 180/717 (25%), Positives = 277/717 (38%), Gaps = 86/717 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ +GE++ P R+ +
Sbjct: 37 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 94
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
+ + D G Y CV G ++++ + F+ PT GE A++ C
Sbjct: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
P PTI WK K + I K+ R I + L I +K+D G Y C G + GE
Sbjct: 155 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 211
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ ++ V PT R +N ++V C +G P+PT+ W KD + +
Sbjct: 212 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+
Sbjct: 270 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373
+ VT CE G+P P++ W+ + L + + ++R S LT+
Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 379
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
+IQ +DAG YIC A G LEV LQGP + C
Sbjct: 380 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 439
Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
+ P ISW ++G P + + I+ T L + +D G Y C A +
Sbjct: 440 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 494
Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
G+ S +L +D P PS QV + + +P G +P
Sbjct: 495 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 554
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+
Sbjct: 555 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 611
Query: 593 -FKTQPVHSPPP-------------PASASSSTPVPLSPP--DTTWPLP----------- 625
+TQ + SPP PV L+P TW +
Sbjct: 612 PVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRV 670
Query: 626 ALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWK 682
T + S L+ ++ + +++ VNL K +R Y ++ + SE K
Sbjct: 671 MYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK 727
Score = 53.9 bits (128), Expect = 5e-07
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ S++ LEV Q P V G
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TI W +D ++ I I L ++ ++D G Y C
Sbjct: 151 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 205
Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525
N +G+ + E + + T I+QV E QVQ D P+ T
Sbjct: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 255
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 155 bits (391), Expect = 2e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2685
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 2686 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 2744 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2799
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 2800 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2856
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2907
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 2908 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 2967
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 2968 IHWIKDGLPLRGSHLRH-QLQN----GSLTIRRTERDDAGRYQCLAENEMGVAKKVVILV 3022
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 3023 LQSAP----VFQVEPQDMTVR 3039
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 1762 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1815
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 1816 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 1875 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 1931
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 1992 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2102
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 2103 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 2162 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2212
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 1389 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1443
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 1444 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1503
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 1504 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1558
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1615
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 1616 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1675
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 1676 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1728
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 1729 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1788
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 1789 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1844
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 1845 ENPKTETVSQV 1855
Score = 141 bits (356), Expect = 2e-33
Identities = 119/455 (26%), Positives = 203/455 (44%), Gaps = 37/455 (8%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATV 110
+SW+ +G L P R V + D + L + A++ DAG Y C + G SE +
Sbjct: 820 LSWWK-DGRPLEP---RPGVHLSADKA-LLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 874
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK-KDVRFIVL 169
NV + + + T REG + C+ P I W+ G+ + + ++ +
Sbjct: 875 NVWVAPVFPLRESHT-LTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSA 933
Query: 170 SNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQ 229
L + + EGTY CE + + +D+Q+ V+VPP I + + +
Sbjct: 934 VGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQD 991
Query: 230 SV-TLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
V TL C+A G P PT++W +DG+ + E + + L +++ Y C+
Sbjct: 992 GVATLECNATGKPPPTVTWERDGQPVGAELGLQ---LQNQGQSLHVERAQAAHTGRYSCV 1048
Query: 289 AENKAGEQDATIHLKVFAKPKITY----VENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
AEN AG + L V P++ + N TA L +TL CEA G P P+I W
Sbjct: 1049 AENLAGRAERKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRG 1107
Query: 345 TRNISSEEKT--LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
+S E T L G +++ + Q D+G Y C ASN G+ ++ +EV
Sbjct: 1108 EEPVSPGEDTYLLAGGWMLK---------MTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Query: 403 QYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
P ++ + +G ++ C V +P ++WF+DG+ L + +I +P
Sbjct: 1159 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI----SP 1214
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
L+V + + G+Y+C A N +G+++ F L
Sbjct: 1215 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 1249
Score = 132 bits (331), Expect = 2e-30
Identities = 147/590 (24%), Positives = 224/590 (37%), Gaps = 55/590 (9%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 627 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 686 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 741
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 742 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 800
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 801 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 853
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G + L V AP L+ + EG+ ++CE P IS
Sbjct: 854 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKIS 913
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 914 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 968
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV------- 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 969 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 1028
Query: 545 WHSKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGL-GEISAASEFKTQPVHSP 601
S + +A+ G + V L L+ L L G++ + T +HSP
Sbjct: 1029 GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI-TAALHSP 1087
Query: 602 ----------PPPASASSSTPVPLSPPDTT------WPLPALATTEPAKG 635
PPPA P+SP + T W L T E G
Sbjct: 1088 LTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1137
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 1135 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1193
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 1194 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1250
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1307
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 1308 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVK 1365
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1418
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1534
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 1535 GRYSCKASNEVGEDWLHYELLVLTPP 1560
Score = 130 bits (327), Expect = 5e-30
Identities = 114/431 (26%), Positives = 172/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 2779 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2837
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2888
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 2889 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 2943
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 2944 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 2991
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T++ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3051
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 3052 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3106
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 3107 ARAFLVVRGEP 3117
Score = 129 bits (325), Expect = 8e-30
Identities = 157/640 (24%), Positives = 247/640 (38%), Gaps = 77/640 (12%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 2046 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2099
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 2100 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2151
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 2152 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2204
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2262
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 2263 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2314
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 2315 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2367
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE----SLEFILVQ 496
L P S I P S L + P D G+Y C A N G + L +
Sbjct: 2428 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP 2482
Query: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 556
A PS ++ + TA P G P K W G+++ A
Sbjct: 2483 AIAPSPSNL------TLTAHTPALLPCEASGSP--KPLVVWWKDGQKLDFRLQQGAYRLL 2534
Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLS 616
+ + P+ + N E+ A VH PP A + V +
Sbjct: 2535 PSNALLLTAPGPQDSAQFECVVSN-----EVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 2589
Query: 617 PPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
P L +T PA S K Q+G G+ +V+
Sbjct: 2590 APVV---LTCHSTGIPAP-TVSWSKAGAQLGARGSGYRVS 2625
Score = 123 bits (309), Expect = 6e-28
Identities = 116/458 (25%), Positives = 192/458 (41%), Gaps = 52/458 (11%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQ------EFREGE 133
L I NA +DAG Y CVVT E G E+ +V++ + K+ P + + +
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS 1373
Query: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
+ C+ + PPTI W G+ V ++ ++ LQI+ + +D G Y C
Sbjct: 1374 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 194 LARGEINFKDIQVIVNVPPTIQ------ARQNIVNATANLGQSVT------------LVC 235
+A GE + +D V++ VPP Q A I++ VT L C
Sbjct: 1433 VA-GE-DDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYC 1490
Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
D P P ++W ++ + + DE + L I V + Y C A N+ GE
Sbjct: 1491 DTNAIPPPDLTWYREDQPL--SAGDEVSVL-QGGRVLQIPLVRAENAGRYSCKASNEVGE 1547
Query: 296 QDATIHLKVFAKPKI----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSE 351
L V P I + + + V+L C A G+P+P+I+W + S
Sbjct: 1548 DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 1607
Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410
+ + V +V L + + + DA Y+C A N G + L VQ P++ G
Sbjct: 1608 PR-----LQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGL 1660
Query: 411 -PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPD 469
V + V++ C+V A+P+ ++W++D Q L +++ P L++
Sbjct: 1661 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE----EVFLLPGTHTLQLGRA 1716
Query: 470 SENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 507
+D G Y C A+N G++ LVQ P+ Q
Sbjct: 1717 RLSDSGMYTCEALNAAGRDQK---LVQLSVLVPPAFRQ 1751
Score = 120 bits (300), Expect = 6e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2267
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 2268 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 2327 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 2385 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2439
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 2440 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 2497 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2551
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 2612 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2667
Query: 501 SSP 503
P
Sbjct: 2668 VKP 2670
Score = 119 bits (297), Expect = 1e-26
Identities = 87/296 (29%), Positives = 124/296 (41%), Gaps = 31/296 (10%)
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS--- 266
VPP+I+ N + GQS+TL CDA GFP P + W KD + + Y +
Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 267 ---------DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV-ENQ 316
D+ L ++ + D Y C AEN+AG HL V P + Q
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134
Query: 317 TAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG--HMVVRSHARVSSLTLK 373
+ L V L C SG P P + W + L G H+ V+ +V +T
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEW------TKDRQPVLPGGPHLQVQEDGQVLRITGS 188
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFA 430
+ D G Y C A + GQ ++ L V P + G V E + V + CE
Sbjct: 189 HV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246
Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
P+ I+WF+DG LLP+S K+ T L++ +D G Y C A N +G
Sbjct: 247 VPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298
Score = 116 bits (290), Expect = 9e-26
Identities = 104/436 (23%), Positives = 167/436 (38%), Gaps = 24/436 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ +A D+G Y CV G + + V +++ E + C
Sbjct: 753 LTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQ 811
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ PP + W GR + + V + LQ+ D G Y CE L + +
Sbjct: 812 SHAMPPPVLSWWKDGRPLEPRPGVH-LSADKALLQVDRADVWDAGHYTCEA--LNQAGHS 868
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K + V V P R++ T G L C+ G P P +SW KDG+ + E
Sbjct: 869 EKHYNLNVWVAPVFPLRESHT-LTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAG 927
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QT 317
+++ S L + + E Y C N G + L+V P+I Q
Sbjct: 928 LQHV-SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV 986
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ + TL C A+G P P++TW + + +E + ++ + SL ++ Q
Sbjct: 987 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-------LGLQLQNQGQSLHVERAQA 1039
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT----WEGNQVNITCEVFAYPS 433
G Y C A N G+ + L V P+L G + T + + + CE P
Sbjct: 1040 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 1099
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I WFR + + + Y L++T E D G Y+C A N G+ F
Sbjct: 1100 PAIRWFRGEEPVSPGEDT----YLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFS 1155
Query: 494 LVQADTPSSPSIDQVE 509
+ PS + D E
Sbjct: 1156 VEVLVPPSIENEDLEE 1171
Score = 114 bits (284), Expect = 4e-25
Identities = 105/452 (23%), Positives = 170/452 (37%), Gaps = 43/452 (9%)
Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
D+ W G +L D +L D+G+Y C + G+ ++
Sbjct: 71 DLGWGQVGGHRLL------------DEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDF 117
Query: 111 NVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
++ + A QE G D + C P + W + V+ +
Sbjct: 118 HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ 177
Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
L+I G DEG Y+C A + +D Q+ V+ PPTI
Sbjct: 178 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMED 235
Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
V L+C+A G P P ++W KDG + K +++ QL + + +D Y C
Sbjct: 236 HLVQLLCEARGVPTPNITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292
Query: 289 AENKAGEQDATIHLKVFAKPKI------TYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
A N G + L V+ P I YV A V L C A G P P+++W
Sbjct: 293 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWH 349
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
++ ++ R S L L+S +G Y C AS+ G+ +EV
Sbjct: 350 HEGLPVAESNES-------RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 402
Query: 403 QYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
Q P+L +G V T G + + C+ P TI W ++G+ P+ + +++
Sbjct: 403 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--AS 458
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
+ L + + G + C A N G E
Sbjct: 459 QGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490
Score = 110 bits (274), Expect = 6e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 228 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 281
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 282 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 341 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 397
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 398 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 455
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 456 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 514
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 515 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 572
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 573 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 632
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 633 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687
Score = 106 bits (264), Expect = 9e-23
Identities = 95/382 (24%), Positives = 162/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 2770 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2823
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 2824 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 2883 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 2932
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 2933 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 2987
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI++ +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3096
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 3097 VAHNLLGSATARAFLVVRGEPQ 3118
Score = 61.6 bits (148), Expect = 3e-09
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 22/187 (11%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEK-----------TLDGHMVVRSHARVSSLT 371
+ +TL C+A+G P+P I W + + + GH ++ SL
Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLH 90
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITCEV 428
IQ D+G Y C A N G + +L V P + G A V G V + C
Sbjct: 91 FPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWT 150
Query: 429 FAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
P+ + W +D Q +LP + ++ L +T D G Y C A + GQ
Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 488 ESLEFIL 494
++ +F L
Sbjct: 207 QARDFQL 213
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 154 bits (390), Expect = 2e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 2835 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2890
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 2891 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2947
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2998
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 2999 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 3058
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 3059 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 3113
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 3114 LQSAP----VFQVEPQDMTVR 3130
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 1853 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1906
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 1907 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 1966 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 2022
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 2083 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2193
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 2194 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 2253 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2303
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 1480 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1534
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 1535 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1594
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 1595 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1649
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1706
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 1707 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1766
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 1767 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1819
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 1820 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1879
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 1880 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1935
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 1936 ENPKTETVSQV 1946
Score = 142 bits (357), Expect = 2e-33
Identities = 119/455 (26%), Positives = 203/455 (44%), Gaps = 37/455 (8%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATV 110
+SW+ +G L P R V + D + L + A++ DAG Y C + G SE +
Sbjct: 911 LSWWK-DGRPLEP---RPGVHLSADKA-LLQVDRADVWDAGHYTCEALNQAGRSEKHYNL 965
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK-KDVRFIVL 169
NV + + + T REG + C+ P I W+ G+ + + ++ +
Sbjct: 966 NVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSA 1024
Query: 170 SNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQ 229
L + + EGTY CE + + +D+Q+ V+VPP I + + +
Sbjct: 1025 VGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQD 1082
Query: 230 SV-TLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
V TL C+A G P PT++W +DG+ + E + + L +++ Y C+
Sbjct: 1083 GVATLECNATGKPPPTVTWERDGQPVGAELGLQ---LQNQGQSLHVERAQAAHTGRYSCV 1139
Query: 289 AENKAGEQDATIHLKVFAKPKITY----VENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
AEN AG + L V P++ + N TA L +TL CEA G P P+I W
Sbjct: 1140 AENLAGRAERKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRG 1198
Query: 345 TRNISSEEKT--LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
+S E T L G +++ + Q D+G Y C ASN G+ ++ +EV
Sbjct: 1199 EEPVSPGEDTYLLAGGWMLK---------MTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Query: 403 QYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
P ++ + +G ++ C V +P ++WF+DG+ L + +I +P
Sbjct: 1250 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI----SP 1305
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
L+V + + G+Y+C A N +G+++ F L
Sbjct: 1306 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 1340
Score = 132 bits (333), Expect = 9e-31
Identities = 147/590 (24%), Positives = 226/590 (38%), Gaps = 55/590 (9%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 718 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 777 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 832
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 833 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 891
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 892 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 944
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G+ + L V AP L+ + EG+ +++CE P IS
Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 1004
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 1005 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 1059
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV------- 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 1119
Query: 545 WHSKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGL-GEISAASEFKTQPVHSP 601
S + +A+ G + V L L+ L L G++ + T +HSP
Sbjct: 1120 GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI-TAALHSP 1178
Query: 602 ----------PPPASASSSTPVPLSPPDTT------WPLPALATTEPAKG 635
PPPA P+SP + T W L T E G
Sbjct: 1179 LTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1228
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 1226 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1284
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 1285 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1341
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 1342 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1398
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 1399 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 1456
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1509
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1569
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1625
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 1626 GRYSCKASNEVGEDWLHYELLVLTPP 1651
Score = 129 bits (325), Expect = 8e-30
Identities = 157/640 (24%), Positives = 247/640 (38%), Gaps = 77/640 (12%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 2137 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2190
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 2191 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2242
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 2243 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2295
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2353
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 2354 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2405
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 2406 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2458
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 2459 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE----SLEFILVQ 496
L P S I P S L + P D G+Y C A N G + L +
Sbjct: 2519 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP 2573
Query: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 556
A PS ++ + TA P G P K W G+++ A
Sbjct: 2574 AIAPSPSNL------TLTAHTPALLPCEASGSP--KPLVVWWKDGQKLDFRLQQGAYRLL 2625
Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLS 616
+ + P+ + N E+ A VH PP A + V +
Sbjct: 2626 PSNALLLTAPGPQDSAQFECVVSN-----EVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 2680
Query: 617 PPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
P L +T PA S K Q+G G+ +V+
Sbjct: 2681 APVV---LTCHSTGIPAP-TVSWSKAGAQLGARGSGYRVS 2716
Score = 129 bits (324), Expect = 1e-29
Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 2870 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2928
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2979
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 2980 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 3034
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 3035 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 3082
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3142
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 3143 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3197
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 3198 ARAFLVVRGEP 3208
Score = 123 bits (308), Expect = 7e-28
Identities = 116/458 (25%), Positives = 192/458 (41%), Gaps = 52/458 (11%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQ------EFREGE 133
L I NA +DAG Y CVVT E G E+ +V++ + K+ P + + +
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 1464
Query: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
+ C+ + PPTI W G+ V ++ ++ LQI+ + +D G Y C
Sbjct: 1465 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 194 LARGEINFKDIQVIVNVPPTIQ------ARQNIVNATANLGQSVT------------LVC 235
+A GE + +D V++ VPP Q A I++ VT L C
Sbjct: 1524 VA-GE-DDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYC 1581
Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
D P P ++W ++ + + DE + L I V + Y C A N+ GE
Sbjct: 1582 DTNAIPPPDLTWYREDQPL--SAGDEVSVL-QGGRVLQIPLVRAENAGRYSCKASNEVGE 1638
Query: 296 QDATIHLKVFAKPKI----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSE 351
L V P I + + + V+L C A G+P+P+I+W + S
Sbjct: 1639 DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 1698
Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410
+ + V +V L + + + DA Y+C A N G + L VQ P++ G
Sbjct: 1699 PR-----LQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGL 1751
Query: 411 -PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPD 469
V + V++ C+V A+P+ ++W++D Q L +++ P L++
Sbjct: 1752 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE----EVFLLPGTHTLQLGRA 1807
Query: 470 SENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 507
+D G Y C A+N G++ LVQ P+ Q
Sbjct: 1808 RLSDSGMYTCEALNAAGRDQK---LVQLSVLVPPAFRQ 1842
Score = 120 bits (300), Expect = 6e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2358
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 2359 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 2418 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 2476 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2530
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 2531 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 2588 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2642
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 2703 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2758
Query: 501 SSP 503
P
Sbjct: 2759 VKP 2761
Score = 117 bits (292), Expect = 5e-26
Identities = 104/436 (23%), Positives = 168/436 (38%), Gaps = 24/436 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ +A D+G Y CV G + + V +++ E + C
Sbjct: 844 LTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQ 902
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ PP + W GR + + V + LQ+ D G Y CE L + +
Sbjct: 903 SHAMPPPVLSWWKDGRPLEPRPGVH-LSADKALLQVDRADVWDAGHYTCEA--LNQAGRS 959
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K + V V P R++ T G +L C+ G P P +SW KDG+ + E
Sbjct: 960 EKHYNLNVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAG 1018
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QT 317
+++ S L + + E Y C N G + L+V P+I Q
Sbjct: 1019 LQHV-SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV 1077
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ + TL C A+G P P++TW + + +E + ++ + SL ++ Q
Sbjct: 1078 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-------LGLQLQNQGQSLHVERAQA 1130
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT----WEGNQVNITCEVFAYPS 433
G Y C A N G+ + L V P+L G + T + + + CE P
Sbjct: 1131 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 1190
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I WFR + + + Y L++T E D G Y+C A N G+ F
Sbjct: 1191 PAIRWFRGEEPVSPGEDT----YLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFS 1246
Query: 494 LVQADTPSSPSIDQVE 509
+ PS + D E
Sbjct: 1247 VEVLVPPSIENEDLEE 1262
Score = 112 bits (280), Expect = 1e-24
Identities = 121/485 (24%), Positives = 184/485 (37%), Gaps = 52/485 (10%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C G K + ++W + Q ++V+ +L + + + D+G Y+C T
Sbjct: 24 CGTHGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGDYECQATN 78
Query: 101 EDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI 159
E GS S A + V + + G+ + CD P I+W + V
Sbjct: 79 EVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTY----RCE-GRILARGEINFKDIQVIVN----- 209
+ + Q+ G + DEG R + GR RG Q
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 210 ---------------VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
PP++ G V L C G P P + WTKD + +
Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV 258
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
+D L I DE Y C+A + AG+Q L+V A P I +
Sbjct: 259 --LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGS 315
Query: 315 NQT---AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
N+T A+ + V L CEA G P P+ITW + + K +V R L
Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQ 368
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCE 427
L Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 428
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
+PS T+SW +G + SN S ++ S L + E G Y+C A + G+
Sbjct: 429 ARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGE 484
Query: 488 ESLEF 492
L++
Sbjct: 485 AVLQY 489
Score = 110 bits (274), Expect = 6e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 319 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 372
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 432 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 488
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 489 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 546
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 547 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 605
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 606 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 663
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 664 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 723
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 724 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Score = 108 bits (271), Expect = 1e-23
Identities = 91/369 (24%), Positives = 144/369 (39%), Gaps = 28/369 (7%)
Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG 191
G D + C P + W + V+ + L+I G DEG Y+C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 192 RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG 251
A + +D Q+ V+ PPTI V L+C+A G P P ++W KDG
Sbjct: 292 FSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349
Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI- 310
+ K +++ QL + + +D Y C A N G + L V+ P I
Sbjct: 350 ALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 406
Query: 311 -----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
YV A V L C A G P P+++W ++ ++ R
Sbjct: 407 GAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWHHEGLPVAESNES-------RLET 456
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQV 422
S L L+S +G Y C AS+ G+ +EVQ P+L +G V T G +
Sbjct: 457 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 516
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
+ C+ P TI W ++G+ P+ + +++ + L + + G + C A
Sbjct: 517 ELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--ASQGTTLHIDHVELDHSGLFACQAT 572
Query: 483 NRIGQESLE 491
N G E
Sbjct: 573 NEAGTAGAE 581
Score = 105 bits (262), Expect = 2e-22
Identities = 138/589 (23%), Positives = 229/589 (38%), Gaps = 52/589 (8%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
+ L I +++ D G Y+CV G ++ + + V + N E
Sbjct: 269 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 328
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFI-VLSNNYLQIRGIKKTDEGTYRCE-GR 192
++C+ P I W G +L + + LQ+ + +D G Y C+
Sbjct: 329 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386
Query: 193 ILARGEINFKDIQVIVNVPPTIQ---ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW
Sbjct: 387 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 441
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G + + + D S L ++ + Y C+A + AGE ++V P+
Sbjct: 442 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 498
Query: 310 ITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+ E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 551
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424
++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + +
Sbjct: 552 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 610
Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473
+ P W +G P S + + I + Y+ P L++ D
Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 668
Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY 533
G Y C A N G+ E L P+ + A V + GVP
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE--CLASGVP--PP 724
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
W + V S W + ++ I + + R A N G E+
Sbjct: 725 DVSWFKGHQPV--SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 782
Query: 594 KTQPVHSPPP--PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAP 640
P + PP P +TPV L+ T P P L + G P +P
Sbjct: 783 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DGNPVSP 829
Score = 105 bits (261), Expect = 2e-22
Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 2861 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2914
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 2915 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 2974 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 3023
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 3024 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 3078
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI + +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3187
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 3188 VAHNLLGSATARAFLVVRGEPQ 3209
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G V + C P+ + W +D Q +LP + ++ L +T D G Y
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRY 287
Query: 478 NCTAVNRIGQESLEFIL 494
C A + GQ++ +F L
Sbjct: 288 QCVAFSPAGQQARDFQL 304
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 154 bits (390), Expect = 2e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 4026 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 4081
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 4082 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 4138
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 4189
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 4190 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 4249
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 4250 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 4304
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 4305 LQSAP----VFQVEPQDMTVR 4321
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 3044 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 3097
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 3098 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 3157 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 3213
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 3274 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 3384
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 3385 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 3444 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 3494
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 2671 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 2725
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 2786 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 2840
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 2897
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 2898 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 2957
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 2958 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 3010
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 3011 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 3070
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 3071 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 3126
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 3127 ENPKTETVSQV 3137
Score = 144 bits (363), Expect = 3e-34
Identities = 132/498 (26%), Positives = 203/498 (40%), Gaps = 52/498 (10%)
Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
+ LG V QV P ++ VGE+ C G+ + + +SW S +G L + SV
Sbjct: 1112 YVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSW-SKDGVVLQGRGPQGSV 1169
Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQ--EF 129
+ +S DAG Y+C + G ++ V +++ + + T E
Sbjct: 1170 HFAAIRTS----------DAGRYRCEASNSAGVDAWE-VELRVLEPPHWGADETSGLLER 1218
Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
GE+A + C + P + W+ L VL L + + D G Y C
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278
Query: 190 EGRILARGEINF--KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
+ A E+ + +++V VPP+I+ N + GQS+TL CDA GFP P + W
Sbjct: 1279 Q----ATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 248 TKDGEQIEQEEDDEKYIFS------------DDSSQLTIKKVDKNDEAEYICIAENKAGE 295
KD + + Y + D+ L ++ + D Y C AEN+AG
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394
Query: 296 QDATIHLKVFAKPKITYV-ENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEK 353
HL V P + Q + L V L C SG P P + W +
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW------TKDRQP 1448
Query: 354 TLDG--HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410
L G H+ V+ +V +T + D G Y C A + GQ ++ L V P + G
Sbjct: 1449 VLPGGPHLQVQEDGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 1506
Query: 411 --PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468
V E + V + CE P+ I+WF+DG LLP+S K+ T L++
Sbjct: 1507 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGR 1562
Query: 469 DSENDFGNYNCTAVNRIG 486
+D G Y C A N +G
Sbjct: 1563 AQSSDAGVYTCKASNAVG 1580
Score = 142 bits (357), Expect = 2e-33
Identities = 119/455 (26%), Positives = 203/455 (44%), Gaps = 37/455 (8%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATV 110
+SW+ +G L P R V + D + L + A++ DAG Y C + G SE +
Sbjct: 2102 LSWWK-DGRPLEP---RPGVHLSADKA-LLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 2156
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK-KDVRFIVL 169
NV + + + T REG + C+ P I W+ G+ + + ++ +
Sbjct: 2157 NVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSA 2215
Query: 170 SNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQ 229
L + + EGTY CE + + +D+Q+ V+VPP I + + +
Sbjct: 2216 VGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQD 2273
Query: 230 SV-TLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
V TL C+A G P PT++W +DG+ + E + + L +++ Y C+
Sbjct: 2274 GVATLECNATGKPPPTVTWERDGQPVGAELGLQ---LQNQGQSLHVERAQAAHTGRYSCV 2330
Query: 289 AENKAGEQDATIHLKVFAKPKITY----VENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
AEN AG + L V P++ + N TA L +TL CEA G P P+I W
Sbjct: 2331 AENLAGRAERKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRG 2389
Query: 345 TRNISSEEKT--LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
+S E T L G +++ + Q D+G Y C ASN G+ ++ +EV
Sbjct: 2390 EEPVSPGEDTYLLAGGWMLK---------MTQTQEQDSGLYSCLASNEAGEARRNFSVEV 2440
Query: 403 QYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
P ++ + +G ++ C V +P ++WF+DG+ L + +I +P
Sbjct: 2441 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI----SP 2496
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
L+V + + G+Y+C A N +G+++ F L
Sbjct: 2497 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL 2531
Score = 140 bits (354), Expect = 3e-33
Identities = 137/488 (28%), Positives = 197/488 (40%), Gaps = 49/488 (10%)
Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
QV I S S G C +G ISW + + RI V D+ T
Sbjct: 609 QVSIHTSSQHFSQGVEVKVSCSASG-YPTPHISWSRES--QALQEDSRIHV----DAQGT 661
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE------GED 134
L I +DAG Y C T E G++ E L + + P+ GE+
Sbjct: 662 LIIQGVAPEDAGNYSCQATNEVGTDQETVT-------LYYTDPPSVSAVNAVVLVAVGEE 714
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
AV+VC+ PP +IW G ++IL + S+ L+I ++ D GTY C
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCR---- 766
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQ 253
A E+ ++ + V Q + + T LG+S L C A G P PT++W + DG+
Sbjct: 767 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826
Query: 254 IEQEEDDEKYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV--FAKPK 309
+ + S DS L + V D+A Y+C A N G+ A L V A P+
Sbjct: 827 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886
Query: 310 ITYVENQTAMELEEQVTLTCEA-SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368
I + + V+L C +G P+P W R + + S
Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR--------HSIRADG 938
Query: 369 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY--TWEGNQVNITC 426
SL L AG Y C A+NT G + + L VQ P++ P A + T EG ++ C
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH-PTATHHITNEGVPASLPC 997
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
P+ TI+W ++ L S YN L + S D G Y CTA N +G
Sbjct: 998 VASGVPAPTITWTKETNALTSRGPH----YNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 1053
Query: 487 QESLEFIL 494
S E L
Sbjct: 1054 FSSQEMRL 1061
Score = 132 bits (332), Expect = 1e-30
Identities = 147/590 (24%), Positives = 225/590 (38%), Gaps = 55/590 (9%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 1909 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 1968 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 2023
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 2024 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 2082
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 2083 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 2135
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G + L V AP L+ + EG+ +++CE P IS
Sbjct: 2136 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 2195
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 2196 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 2250
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV------- 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 2251 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 2310
Query: 545 WHSKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGL-GEISAASEFKTQPVHSP 601
S + +A+ G + V L L+ L L G++ + T +HSP
Sbjct: 2311 GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI-TAALHSP 2369
Query: 602 ----------PPPASASSSTPVPLSPPDTT------WPLPALATTEPAKG 635
PPPA P+SP + T W L T E G
Sbjct: 2370 LTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 2419
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 2417 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 2475
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 2476 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 2532
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 2589
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 2590 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 2647
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 2700
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 2816
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 2817 GRYSCKASNEVGEDWLHYELLVLTPP 2842
Score = 130 bits (327), Expect = 5e-30
Identities = 120/473 (25%), Positives = 199/473 (42%), Gaps = 37/473 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ C+V G+A +++W + L + R++ + + +L I D
Sbjct: 528 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 581
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G Y+CV + +G + A+V + + + + Q F +G + + C P I
Sbjct: 582 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 640
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
W + + L++D R V + L I+G+ D G Y C+ A E+ + + +
Sbjct: 641 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 694
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
PP++ A +V +G+ LVC+A G P P + W + G E I E
Sbjct: 695 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 745
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S +L I + D Y C A N+ G+ A I L V P++T + +EL L
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386
C A+G P P++TWR L RS S L +S+ D Y+C
Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 863
Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442
A N G+ +++ + +AP V EG V++ C V A P W +DG
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ LP + +I+ + L + + G Y+C A N G + + LV
Sbjct: 924 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 971
Score = 129 bits (325), Expect = 8e-30
Identities = 157/640 (24%), Positives = 247/640 (38%), Gaps = 77/640 (12%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 3328 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 3381
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 3382 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 3433
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 3434 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 3486
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 3544
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 3545 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 3596
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 3597 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 3649
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 3650 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE----SLEFILVQ 496
L P S I P S L + P D G+Y C A N G + L +
Sbjct: 3710 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP 3764
Query: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 556
A PS ++ + TA P G P K W G+++ A
Sbjct: 3765 AIAPSPSNL------TLTAHTPALLPCEASGSP--KPLVVWWKDGQKLDFRLQQGAYRLL 3816
Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLS 616
+ + P+ + N E+ A VH PP A + V +
Sbjct: 3817 PSNALLLTAPGPQDSAQFECVVSN-----EVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 3871
Query: 617 PPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
P L +T PA S K Q+G G+ +V+
Sbjct: 3872 APVV---LTCHSTGIPAP-TVSWSKAGAQLGARGSGYRVS 3907
Score = 129 bits (324), Expect = 1e-29
Identities = 124/481 (25%), Positives = 194/481 (40%), Gaps = 43/481 (8%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE+ C G K + ++W + Q ++V+ +L + + + D+G
Sbjct: 1221 GENASLPCPARGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGD 1275
Query: 94 YKCVVTGEDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
Y+C T E GS S A + V + + G+ + CD P I+W
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335
Query: 153 HKGRDVILKK-------DVRFIVLSNNYLQIRG-------IKKTDEGTYRCEGRILARGE 198
+ V + D+ + + + L G I++ D G Y C A G
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA-GT 1394
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+D ++V PP++ G V L C G P P + WTKD + +
Sbjct: 1395 AQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG 1453
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT- 317
+ +D L I DE Y C+A + AG+Q L+V A P I + N+T
Sbjct: 1454 PHLQV--QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGSNETG 1510
Query: 318 --AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
A+ + V L CEA G P P+ITW + + K +V R L L
Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQLGRA 1563
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAY 431
Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C +
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 1623
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
PS T+SW +G + SN S ++ S L + E G Y+C A + G+ L+
Sbjct: 1624 PSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679
Query: 492 F 492
+
Sbjct: 1680 Y 1680
Score = 129 bits (324), Expect = 1e-29
Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 4061 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 4119
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 4170
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 4171 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 4225
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 4226 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 4273
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 4333
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 4334 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 4388
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 4389 ARAFLVVRGEP 4399
Score = 123 bits (308), Expect = 7e-28
Identities = 154/647 (23%), Positives = 238/647 (36%), Gaps = 95/647 (14%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
++VGE +C+ +G + I W+ E + + SS L I A D
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 759
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
AG Y C E G S A + + + P G A++ C PPT+
Sbjct: 760 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 818
Query: 151 WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
W+ G+ + L+ + R + L + D+ Y CE R + G++ +
Sbjct: 819 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 877
Query: 206 VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263
++ + PP I + V GQ V+L C G P P W KDG + ++
Sbjct: 878 IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 932
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
D S L + + + Y C+A N AG Q + L V P+I
Sbjct: 933 SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 991
Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
+L C ASG P P+ITW T ++S H V ++ +L + DAG Y
Sbjct: 992 PASLPCVASGVPAPTITWTKETNALTSRGP----HYNV---SKEGTLLIAQPSAQDAGAY 1044
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
+CTA+NT+G SQ M L V + ++ Y WE +
Sbjct: 1045 VCTATNTVGFSSQEMRLSVN-----RLALSKYVWE----------------------EYG 1077
Query: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 503
LLPS + L + D G+Y CTA N G S ++L P
Sbjct: 1078 LLPSGS--------------LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPP--- 1120
Query: 504 SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 563
QV+P +V G L AE + W + +G V
Sbjct: 1121 ---QVQPGPRVLKV------LVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHF 1171
Query: 564 VGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWP 623
++ R A N G+ A E + + + P A +S ++ + + P
Sbjct: 1172 AAIRTSDAGRYRCEASNSAGVD----AWEVELRVLEPPHWGADETSGLLERVAGENASLP 1227
Query: 624 LPALATTEPA---KGEPSAPKLEGQMG----EDGNSIKVNLIKQDDG 663
PA T +P + PS+ L GQ G E+G+ ++ D G
Sbjct: 1228 CPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSG 1274
Score = 123 bits (308), Expect = 7e-28
Identities = 116/458 (25%), Positives = 192/458 (41%), Gaps = 52/458 (11%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQ------EFREGE 133
L I NA +DAG Y CVVT E G E+ +V++ + K+ P + + +
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655
Query: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
+ C+ + PPTI W G+ V ++ ++ LQI+ + +D G Y C
Sbjct: 2656 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 194 LARGEINFKDIQVIVNVPPTIQ------ARQNIVNATANLGQSVT------------LVC 235
+A GE + +D V++ VPP Q A I++ VT L C
Sbjct: 2715 VA-GE-DDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYC 2772
Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
D P P ++W ++ + + DE + L I V + Y C A N+ GE
Sbjct: 2773 DTNAIPPPDLTWYREDQPL--SAGDEVSVL-QGGRVLQIPLVRAENAGRYSCKASNEVGE 2829
Query: 296 QDATIHLKVFAKPKI----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSE 351
L V P I + + + V+L C A G+P+P+I+W + S
Sbjct: 2830 DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 2889
Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410
+ + V +V L + + + DA Y+C A N G + L VQ P++ G
Sbjct: 2890 PR-----LQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGL 2942
Query: 411 -PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPD 469
V + V++ C+V A+P+ ++W++D Q L +++ P L++
Sbjct: 2943 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE----EVFLLPGTHTLQLGRA 2998
Query: 470 SENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 507
+D G Y C A+N G++ LVQ P+ Q
Sbjct: 2999 RLSDSGMYTCEALNAAGRDQK---LVQLSVLVPPAFRQ 3033
Score = 120 bits (300), Expect = 6e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 3502 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 3549
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 3550 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 3609 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 3667 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 3721
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 3722 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 3779 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 3833
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 3894 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 3949
Query: 501 SSP 503
P
Sbjct: 3950 VKP 3952
Score = 117 bits (292), Expect = 5e-26
Identities = 104/436 (23%), Positives = 168/436 (38%), Gaps = 24/436 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ +A D+G Y CV G + + V +++ E + C
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQ 2093
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ PP + W GR + + V + LQ+ D G Y CE L + +
Sbjct: 2094 SHAMPPPVLSWWKDGRPLEPRPGVH-LSADKALLQVDRADVWDAGHYTCEA--LNQAGHS 2150
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K + V V P R++ T G +L C+ G P P +SW KDG+ + E
Sbjct: 2151 EKHYNLNVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAG 2209
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QT 317
+++ S L + + E Y C N G + L+V P+I Q
Sbjct: 2210 LQHV-SAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV 2268
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ + TL C A+G P P++TW + + +E + ++ + SL ++ Q
Sbjct: 2269 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAE-------LGLQLQNQGQSLHVERAQA 2321
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT----WEGNQVNITCEVFAYPS 433
G Y C A N G+ + L V P+L G + T + + + CE P
Sbjct: 2322 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 2381
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I WFR + + + Y L++T E D G Y+C A N G+ F
Sbjct: 2382 PAIRWFRGEEPVSPGEDT----YLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFS 2437
Query: 494 LVQADTPSSPSIDQVE 509
+ PS + D E
Sbjct: 2438 VEVLVPPSIENEDLEE 2453
Score = 110 bits (274), Expect = 6e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 1510 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 1563
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 1679
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 1737
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 1738 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 1796
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 1797 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 1854
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 1855 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 1914
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 1915 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969
Score = 108 bits (270), Expect = 2e-23
Identities = 127/523 (24%), Positives = 191/523 (36%), Gaps = 92/523 (17%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEF--REGED 134
+ +L + A + AG Y CV T GS+ +V++ ++ + PT EG
Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTAGSQHR---DVELVVQVPPRIHPTATHHITNEGVP 992
Query: 135 AVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC---- 189
A + C V S +P PTI W K + + + + V L I D G Y C
Sbjct: 993 ASLPC-VASGVPAPTITWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 190 ------------------------EGRILARGEINFKDIQVI------------------ 207
E +L G + +QV
Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110
Query: 208 -----VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V VPP +Q ++ +G+++ L C AEG PEP +SW+KDG ++
Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVL--VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-- 320
F+ + +D Y C A N AG + L+V P E +E
Sbjct: 1169 VHFA---------AIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
E +L C A G P P +TWR + SSE L G V + SL L S+ D+
Sbjct: 1220 AGENASLPCPARGTPKPQVTWR---KGPSSEP--LHGQPGV-AVLEEGSLFLASVSPADS 1273
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437
G+Y C A+N +G S+ L V P ++ V G + + C+ +P I
Sbjct: 1274 GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333
Query: 438 WFRDGQLLP----------SSNYSNIKIYNT-PSASYLEVTPDSENDFGNYNCTAVNRIG 486
W +D QL+ + + + L E D G Y+C A N+ G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVP 529
+F L+ PS + A + T GVP
Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436
Score = 108 bits (270), Expect = 2e-23
Identities = 110/461 (23%), Positives = 181/461 (39%), Gaps = 40/461 (8%)
Query: 55 FSPNGEKLTPNQQRIS-VVWNDDS---SSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
FS +L+ N+ +S VW + S +L + + D+G Y+C + GS S V
Sbjct: 1054 FSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1113
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+ + + P + GE + C + P + W G V+L+
Sbjct: 1114 -LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDG--VVLQGRG-----P 1165
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
+ I+ +D G YRCE A ++ ++++ V PP A + G++
Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSA--GVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
+L C A G P+P ++W K G E ++ S L + V D +Y C A
Sbjct: 1224 ASLPCPARGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQAT 1281
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI 348
N+ G L V+ P I + + + +TL C+A+G P+P I W + +
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341
Query: 349 SSE-----------EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
+ GH ++ SL IQ D+G Y C A N G +
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQAGTAQRD 1398
Query: 398 MYLEVQYAPKLQGPVA---VYTWEGNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNI 453
+L V P + G A V G V + C P+ + W +D Q +LP + +
Sbjct: 1399 FHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQV 1458
Query: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ L +T D G Y C A + GQ++ +F L
Sbjct: 1459 Q----EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 1495
Score = 107 bits (268), Expect = 3e-23
Identities = 90/366 (24%), Positives = 148/366 (40%), Gaps = 25/366 (6%)
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
++ C V S+LP + + + + L ++ F N+ +I K +EGTY C +
Sbjct: 445 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 501
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G K V+ + PP + N+ T + G++ L C G ++W +D +
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 558
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ L I + D Y C+A N G A++ L V P+++ +
Sbjct: 559 ASTGRVAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 615
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+V ++C ASG P P I+W S E + L + A+ +L ++ +
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 667
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSA 434
DAG Y C A+N +G D +++ L P + AV G + + CE P
Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ W+R G + I S+ L + E D G Y C AVN +G S E L
Sbjct: 728 RVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780
Query: 495 VQADTP 500
P
Sbjct: 781 AVGHAP 786
Score = 105 bits (262), Expect = 2e-22
Identities = 138/589 (23%), Positives = 229/589 (38%), Gaps = 52/589 (8%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
+ L I +++ D G Y+CV G ++ + + V + N E
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 1519
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRCEG-R 192
++C+ P I W G +L + + LQ+ + +D G Y C+
Sbjct: 1520 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577
Query: 193 ILARGEINFKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW
Sbjct: 1578 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 1632
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G + + + D S L ++ + Y C+A + AGE ++V P+
Sbjct: 1633 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 1689
Query: 310 ITYVEN--QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+ E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++
Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 1742
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424
++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + +
Sbjct: 1743 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 1801
Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473
+ P W +G P S + + I + Y+ P L++ D
Sbjct: 1802 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 1859
Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY 533
G Y C A N G+ E L P+ + A V + GVP
Sbjct: 1860 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE--CLASGVP--PP 1915
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
W + V S W + ++ I + + R A N G E+
Sbjct: 1916 DVSWFKGHQPV--SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 1973
Query: 594 KTQPVHSPPP--PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAP 640
P + PP P +TPV L+ T P P L + G P +P
Sbjct: 1974 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLK--DGNPVSP 2020
Score = 105 bits (261), Expect = 2e-22
Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 4052 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 4105
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 4106 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 4165 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 4214
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 4215 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 4269
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI + +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 4378
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 4379 VAHNLLGSATARAFLVVRGEPQ 4400
Score = 89.0 bits (219), Expect = 2e-17
Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%)
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+E++ +S I + K +E Y C A ++AG A + V P +
Sbjct: 469 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 528
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374
E L+C G+ ++TW D ++ S RV+ SL +
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 576
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429
I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C
Sbjct: 577 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 632
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G +
Sbjct: 633 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 687
Query: 490 LEFILVQADTPSSPSIDQV 508
L D PS +++ V
Sbjct: 688 ETVTLYYTDPPSVSAVNAV 706
Score = 43.9 bits (102), Expect = 6e-04
Identities = 52/241 (21%), Positives = 86/241 (35%), Gaps = 18/241 (7%)
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 426
SS + + G Y CTA + G + V P P T G ++C
Sbjct: 479 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 538
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
V ++W RD ++LP+S ++ + LE++ D G Y C A N G
Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 594
Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546
L+ + P + +S +V+ + P + + E +A+ E+
Sbjct: 595 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 651
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPAS 606
+G + I G+ PE A N E+ E T ++ PP S
Sbjct: 652 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATN-----EVGTDQETVTL-YYTDPPSVS 701
Query: 607 A 607
A
Sbjct: 702 A 702
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 154 bits (388), Expect = 4e-37
Identities = 169/609 (27%), Positives = 237/609 (38%), Gaps = 61/609 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
+Y DD + L I+KV D Y C+AEN G+ +A+ L V P
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372
+ L VT CEA+G+P P+I WR + L + +S +R S LT+
Sbjct: 322 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425
++Q +D G YIC N G YLEV P + QGPV ++
Sbjct: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 492
Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y E S W E I GLKP Y + A N G+ + S
Sbjct: 553 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609
Query: 591 SE-FKTQPV 598
S+ KTQ V
Sbjct: 610 SDPVKTQDV 618
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 154 bits (388), Expect = 4e-37
Identities = 169/609 (27%), Positives = 237/609 (38%), Gaps = 61/609 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 74 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 131
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 190
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 191 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 247
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 248 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
+Y DD + L I+KV D Y C+AEN G+ +A+ L V P
Sbjct: 306 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372
+ L VT CEA+G+P P+I WR + L + +S +R S LT+
Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425
++Q +D G YIC N G YLEV P + QGPV ++
Sbjct: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 476 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 531
Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y E S W E I GLKP Y + A N G+ + S
Sbjct: 592 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
Query: 591 SE-FKTQPV 598
S+ KTQ V
Sbjct: 649 SDPVKTQDV 657
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 242
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 243 TNMVGERESE 252
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 150 bits (378), Expect = 6e-36
Identities = 171/612 (27%), Positives = 243/612 (39%), Gaps = 64/612 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV------QYAPKL-QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV + P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG L+ S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLV-STQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQADTP-------SSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ P S+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQPV 598
S S+ KTQ V
Sbjct: 610 SQISDPVKTQDV 621
Score = 120 bits (301), Expect = 5e-27
Identities = 111/421 (26%), Positives = 177/421 (42%), Gaps = 56/421 (13%)
Query: 13 FLGTAVS----LQVDIV-------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
+LG AVS L+V I+ PS ++VGE CQ + ISW +G
Sbjct: 113 YLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISW-KKDGSP 171
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
L +RI++ L I DAG Y CV T G + + ++ F
Sbjct: 172 LDDKDERITI-----RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV 226
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
P+ + A C+ PT+ W+ D L K R+ + ++ L+IR +
Sbjct: 227 KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD--DGELPKS-RYEIRDDHTLKIRKVTA 283
Query: 182 TDEGTYRCEG-RILARGEINFKDIQVIVNVPP--TIQARQNIVNATANLGQSVTLVCDAE 238
D G+Y C ++ + E + + + PP ++ R +V LG++VT C+A
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV----ALGRTVTFQCEAT 339
Query: 239 GFPEPTMSWTKDGEQ-----IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
G P+P + W ++G Q + + ++ S + LTI V ++D YIC N A
Sbjct: 340 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS-QTGDLTITNVQRSDVGYYICQTLNVA 398
Query: 294 GEQDATIHLKVF------AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
G +L+V P I + ++ L+C A+G P+P+I WR
Sbjct: 399 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK---- 454
Query: 348 ISSEEKTLDGHMVVRSHARVSSLT--LKSIQYT---DAGEYICTASNTIGQDSQSMYLEV 402
DG +V +R+ L + I+Y D G Y C AS G+ + S Y+EV
Sbjct: 455 --------DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 403 Q 403
Q
Sbjct: 507 Q 507
Score = 98.2 bits (243), Expect = 2e-20
Identities = 106/427 (24%), Positives = 178/427 (41%), Gaps = 45/427 (10%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK-YIFSDDSSQLTIKKV-----DKND 281
G+ TL C AEG P PT+ W K GE++E ++DD + + S L ++ + D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 282 EAEYICIAENKAGE---QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIP 337
E Y+C+A N GE +A++ + + + + + + E + C+ G P P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQ 396
+I+W+ + + D + +R + + T KS DAG+Y+C +N +G+ +S+
Sbjct: 162 TISWKKDGSPLDDK----DERITIRGGKLMITYTRKS----DAGKYVCVGTNMVGERESE 213
Query: 397 SMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI 455
L V P ++ P + + CE P T+ W +D LP S Y I+
Sbjct: 214 VAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY-EIRD 272
Query: 456 YNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSI----DQVEP 510
+T L++ + D G+Y C A N +G+ E+ + VQ + + DQV
Sbjct: 273 DHT-----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 511 YSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA-----SMEGIVTIVG 565
T Q EATG + WR G + + + + S G +TI
Sbjct: 328 LGRTVTFQC---EATGNPQPAIF---WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 566 LKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
++ LN G I+ A T + PPP ++ D T+ L
Sbjct: 382 VQRSDVGYYICQTLNVAG-SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA-VDGTFVLS 439
Query: 626 ALATTEP 632
+AT P
Sbjct: 440 CVATGSP 446
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 150 bits (378), Expect = 6e-36
Identities = 171/612 (27%), Positives = 243/612 (39%), Gaps = 64/612 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV------QYAPKL-QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV + P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG L+ S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLV-STQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQADTP-------SSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ P S+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQPV 598
S S+ KTQ V
Sbjct: 610 SQISDPVKTQDV 621
Score = 120 bits (301), Expect = 5e-27
Identities = 111/421 (26%), Positives = 177/421 (42%), Gaps = 56/421 (13%)
Query: 13 FLGTAVS----LQVDIV-------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
+LG AVS L+V I+ PS ++VGE CQ + ISW +G
Sbjct: 113 YLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISW-KKDGSP 171
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
L +RI++ L I DAG Y CV T G + + ++ F
Sbjct: 172 LDDKDERITI-----RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV 226
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
P+ + A C+ PT+ W+ D L K R+ + ++ L+IR +
Sbjct: 227 KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD--DGELPKS-RYEIRDDHTLKIRKVTA 283
Query: 182 TDEGTYRCEG-RILARGEINFKDIQVIVNVPP--TIQARQNIVNATANLGQSVTLVCDAE 238
D G+Y C ++ + E + + + PP ++ R +V LG++VT C+A
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV----ALGRTVTFQCEAT 339
Query: 239 GFPEPTMSWTKDGEQ-----IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
G P+P + W ++G Q + + ++ S + LTI V ++D YIC N A
Sbjct: 340 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS-QTGDLTITNVQRSDVGYYICQTLNVA 398
Query: 294 GEQDATIHLKVF------AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
G +L+V P I + ++ L+C A+G P+P+I WR
Sbjct: 399 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK---- 454
Query: 348 ISSEEKTLDGHMVVRSHARVSSLT--LKSIQYT---DAGEYICTASNTIGQDSQSMYLEV 402
DG +V +R+ L + I+Y D G Y C AS G+ + S Y+EV
Sbjct: 455 --------DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 403 Q 403
Q
Sbjct: 507 Q 507
Score = 98.2 bits (243), Expect = 2e-20
Identities = 106/427 (24%), Positives = 178/427 (41%), Gaps = 45/427 (10%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK-YIFSDDSSQLTIKKV-----DKND 281
G+ TL C AEG P PT+ W K GE++E ++DD + + S L ++ + D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 282 EAEYICIAENKAGE---QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIP 337
E Y+C+A N GE +A++ + + + + + + E + C+ G P P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQ 396
+I+W+ + + D + +R + + T KS DAG+Y+C +N +G+ +S+
Sbjct: 162 TISWKKDGSPLDDK----DERITIRGGKLMITYTRKS----DAGKYVCVGTNMVGERESE 213
Query: 397 SMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI 455
L V P ++ P + + CE P T+ W +D LP S Y I+
Sbjct: 214 VAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY-EIRD 272
Query: 456 YNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSI----DQVEP 510
+T L++ + D G+Y C A N +G+ E+ + VQ + + DQV
Sbjct: 273 DHT-----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 511 YSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA-----SMEGIVTIVG 565
T Q EATG + WR G + + + + S G +TI
Sbjct: 328 LGRTVTFQC---EATGNPQPAIF---WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 566 LKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
++ LN G I+ A T + PPP ++ D T+ L
Sbjct: 382 VQRSDVGYYICQTLNVAG-SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA-VDGTFVLS 439
Query: 626 ALATTEP 632
+AT P
Sbjct: 440 CVATGSP 446
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 150 bits (378), Expect = 6e-36
Identities = 171/612 (27%), Positives = 243/612 (39%), Gaps = 64/612 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV------QYAPKL-QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV + P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG L+ S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLV-STQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQADTP-------SSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ P S+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQPV 598
S S+ KTQ V
Sbjct: 610 SQISDPVKTQDV 621
Score = 120 bits (301), Expect = 5e-27
Identities = 111/421 (26%), Positives = 177/421 (42%), Gaps = 56/421 (13%)
Query: 13 FLGTAVS----LQVDIV-------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
+LG AVS L+V I+ PS ++VGE CQ + ISW +G
Sbjct: 113 YLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISW-KKDGSP 171
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
L +RI++ L I DAG Y CV T G + + ++ F
Sbjct: 172 LDDKDERITI-----RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV 226
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
P+ + A C+ PT+ W+ D L K R+ + ++ L+IR +
Sbjct: 227 KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD--DGELPKS-RYEIRDDHTLKIRKVTA 283
Query: 182 TDEGTYRCEG-RILARGEINFKDIQVIVNVPP--TIQARQNIVNATANLGQSVTLVCDAE 238
D G+Y C ++ + E + + + PP ++ R +V LG++VT C+A
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV----ALGRTVTFQCEAT 339
Query: 239 GFPEPTMSWTKDGEQ-----IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
G P+P + W ++G Q + + ++ S + LTI V ++D YIC N A
Sbjct: 340 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS-QTGDLTITNVQRSDVGYYICQTLNVA 398
Query: 294 GEQDATIHLKVF------AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
G +L+V P I + ++ L+C A+G P+P+I WR
Sbjct: 399 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK---- 454
Query: 348 ISSEEKTLDGHMVVRSHARVSSLT--LKSIQYT---DAGEYICTASNTIGQDSQSMYLEV 402
DG +V +R+ L + I+Y D G Y C AS G+ + S Y+EV
Sbjct: 455 --------DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 403 Q 403
Q
Sbjct: 507 Q 507
Score = 98.2 bits (243), Expect = 2e-20
Identities = 106/427 (24%), Positives = 178/427 (41%), Gaps = 45/427 (10%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK-YIFSDDSSQLTIKKV-----DKND 281
G+ TL C AEG P PT+ W K GE++E ++DD + + S L ++ + D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 282 EAEYICIAENKAGE---QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIP 337
E Y+C+A N GE +A++ + + + + + + E + C+ G P P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQ 396
+I+W+ + + D + +R + + T KS DAG+Y+C +N +G+ +S+
Sbjct: 162 TISWKKDGSPLDDK----DERITIRGGKLMITYTRKS----DAGKYVCVGTNMVGERESE 213
Query: 397 SMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI 455
L V P ++ P + + CE P T+ W +D LP S Y I+
Sbjct: 214 VAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY-EIRD 272
Query: 456 YNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSI----DQVEP 510
+T L++ + D G+Y C A N +G+ E+ + VQ + + DQV
Sbjct: 273 DHT-----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 511 YSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA-----SMEGIVTIVG 565
T Q EATG + WR G + + + + S G +TI
Sbjct: 328 LGRTVTFQC---EATGNPQPAIF---WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 566 LKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
++ LN G I+ A T + PPP ++ D T+ L
Sbjct: 382 VQRSDVGYYICQTLNVAG-SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA-VDGTFVLS 439
Query: 626 ALATTEP 632
+AT P
Sbjct: 440 CVATGSP 446
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 150 bits (378), Expect = 6e-36
Identities = 171/612 (27%), Positives = 243/612 (39%), Gaps = 64/612 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV------QYAPKL-QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV + P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG L+ S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLV-STQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQADTP-------SSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ P S+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQPV 598
S S+ KTQ V
Sbjct: 610 SQISDPVKTQDV 621
Score = 120 bits (301), Expect = 5e-27
Identities = 111/421 (26%), Positives = 177/421 (42%), Gaps = 56/421 (13%)
Query: 13 FLGTAVS----LQVDIV-------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
+LG AVS L+V I+ PS ++VGE CQ + ISW +G
Sbjct: 113 YLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISW-KKDGSP 171
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
L +RI++ L I DAG Y CV T G + + ++ F
Sbjct: 172 LDDKDERITI-----RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV 226
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
P+ + A C+ PT+ W+ D L K R+ + ++ L+IR +
Sbjct: 227 KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD--DGELPKS-RYEIRDDHTLKIRKVTA 283
Query: 182 TDEGTYRCEG-RILARGEINFKDIQVIVNVPP--TIQARQNIVNATANLGQSVTLVCDAE 238
D G+Y C ++ + E + + + PP ++ R +V LG++VT C+A
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV----ALGRTVTFQCEAT 339
Query: 239 GFPEPTMSWTKDGEQ-----IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
G P+P + W ++G Q + + ++ S + LTI V ++D YIC N A
Sbjct: 340 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS-QTGDLTITNVQRSDVGYYICQTLNVA 398
Query: 294 GEQDATIHLKVF------AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
G +L+V P I + ++ L+C A+G P+P+I WR
Sbjct: 399 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK---- 454
Query: 348 ISSEEKTLDGHMVVRSHARVSSLT--LKSIQYT---DAGEYICTASNTIGQDSQSMYLEV 402
DG +V +R+ L + I+Y D G Y C AS G+ + S Y+EV
Sbjct: 455 --------DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 403 Q 403
Q
Sbjct: 507 Q 507
Score = 98.2 bits (243), Expect = 2e-20
Identities = 106/427 (24%), Positives = 178/427 (41%), Gaps = 45/427 (10%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK-YIFSDDSSQLTIKKV-----DKND 281
G+ TL C AEG P PT+ W K GE++E ++DD + + S L ++ + D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 282 EAEYICIAENKAGE---QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIP 337
E Y+C+A N GE +A++ + + + + + + E + C+ G P P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQ 396
+I+W+ + + D + +R + + T KS DAG+Y+C +N +G+ +S+
Sbjct: 162 TISWKKDGSPLDDK----DERITIRGGKLMITYTRKS----DAGKYVCVGTNMVGERESE 213
Query: 397 SMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI 455
L V P ++ P + + CE P T+ W +D LP S Y I+
Sbjct: 214 VAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY-EIRD 272
Query: 456 YNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSI----DQVEP 510
+T L++ + D G+Y C A N +G+ E+ + VQ + + DQV
Sbjct: 273 DHT-----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 511 YSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA-----SMEGIVTIVG 565
T Q EATG + WR G + + + + S G +TI
Sbjct: 328 LGRTVTFQC---EATGNPQPAIF---WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 566 LKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
++ LN G I+ A T + PPP ++ D T+ L
Sbjct: 382 VQRSDVGYYICQTLNVAG-SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA-VDGTFVLS 439
Query: 626 ALATTEP 632
+AT P
Sbjct: 440 CVATGSP 446
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 145 bits (366), Expect = 1e-34
Identities = 113/473 (23%), Positives = 211/473 (44%), Gaps = 35/473 (7%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C++ G + K + W+ E ++ R+S V DS + L ++N +++D+G Y C
Sbjct: 7327 CKIGGSPEIK-VLWYKDETEIQESSKFRMSFV---DSVAVLEMHNLSVEDSGDYTCEAHN 7382
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
GS S +T ++K+ + +F+ P P E +G D + C++ + P + W R+ L
Sbjct: 7383 AAGSASSST-SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRE--L 7439
Query: 161 KKDVRFIVLSNNYL---QIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQ 215
+ ++ ++S N+L I + D G Y+C+ A ++ + + PP
Sbjct: 7440 RSGKKYKIMSENFLTSIHILNVDAADIGEYQCK----ATNDVGSDTCVGSIALKAPPRFV 7495
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
+ + ++ +G+ V L EG ++ W KD +I +E D+ +S++ + L
Sbjct: 7496 KKLSDISTV--VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS 7553
Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP 335
+V+ + +Y C +N AG Q+ L V I + + TL C +G P
Sbjct: 7554 RVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613
Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
S W + ++S+ K + +VS L + ++ +D+G Y N +G+DS
Sbjct: 7614 ELSTKWFKDGKELTSDNK-----YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDS 7668
Query: 396 QSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448
+ L+V + KL+ + G+ V + C+V+ P ++SWF +G + S
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGL---SGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725
Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
+ T + L V E+D G+Y C A N G + L + PS
Sbjct: 7726 RKYQTTL--TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS 7776
Score = 144 bits (363), Expect = 3e-34
Identities = 134/595 (22%), Positives = 248/595 (41%), Gaps = 51/595 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P +++ G++ C VAG + WF E + N+ +IS + S L I N
Sbjct: 7592 PESIKVTTGDTCTLECTVAG-TPELSTKWFKDGKELTSDNKYKISFF---NKVSGLKIIN 7647
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVV 142
D+G+Y V G +S T ++++ + + F G V+ C V
Sbjct: 7648 VAPSDSGVYSFEVQNPVGKDS-CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY 7706
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINF 201
S P ++ W H+G ++ + + + N L + ++++D G Y C +A +
Sbjct: 7707 GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDEC- 7765
Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+ V PP+ + + ++ G +VT +G P ++SW K ++ D
Sbjct: 7766 -SAPLTVREPPSFVQKPDPMDVLT--GTNVTFTSIVKGTPPFSVSWFKGSSELVPG-DRC 7821
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321
D ++L + VD + EY CI N+AG+ T HL + A K N ++E
Sbjct: 7822 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEK 7881
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
+ + L +G P S+TW+ + N++ ++ + + + + L + S DAG
Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQR-----CNITTTEKSAILEIPSSTVEDAG 7936
Query: 382 EYICTASNTIGQDS---QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
+Y C N G+DS Q + LE Y K PV V G+ ++ C++ P +SW
Sbjct: 7937 QYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSV--GDSASLQCQLAGTPEIGVSW 7994
Query: 439 FR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
++ D +L P++ Y K++ + + L ND G Y C A N +G+ S L
Sbjct: 7995 YKGDTKLRPTTTY---KMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051
Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY------- 550
+ PS + Q + + T G+P++ + G E WY
Sbjct: 8052 EQKLPPSFSR----------QLRDVQETVGLPVV---FDCAISGSEPISVSWYKDGKPLK 8098
Query: 551 ---DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPP 602
+ + + ++ T+ K + + A + + +G S+++ +PP
Sbjct: 8099 DSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPP 8153
Score = 134 bits (337), Expect = 3e-31
Identities = 131/551 (23%), Positives = 221/551 (40%), Gaps = 52/551 (9%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G+S F CQ+ G K + +SW+ E + IS + D +T I A ++++G
Sbjct: 4876 GQSTTFECQITGTPKIR-VSWYLDGNEITAIQKHGISFI---DGLATFQISGARVENSGT 4931
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C + G+ S ++ +K+ + F P E + D + C+V + P + W
Sbjct: 4932 YVCEARNDAGTAS-CSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990
Query: 154 KGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPP 212
R++ K + + L I +D G Y+C + G +V + PP
Sbjct: 4991 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCI--VSNEGGSCSCSTRVALKEPP 5048
Query: 213 TIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQ 271
+ + I N T L S T G P +++W KD + ++ EDD YI F D +
Sbjct: 5049 SFIKK--IENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD--EDDNVYISFVDSVAT 5104
Query: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
L I+ VD Y C A+N++G + L V +I + ++ +TL C
Sbjct: 5105 LQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV 5164
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391
+G P + W + I + + V+S ++S+ D+G+Y N
Sbjct: 5165 AGTPELKVKWLKDGKQIVPSR-----YFSMSFENNVASFRIQSVMKQDSGQYTFKVENDF 5219
Query: 392 GQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
G S YL V + KL V G+ +++ C+V + WF+DG+
Sbjct: 5220 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPISAQWFKDGKE 5276
Query: 445 LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS--- 501
+ +S + ++ + LEV D NY C N G ++ IL + PS
Sbjct: 5277 ISTS--AKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV 5334
Query: 502 SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561
P Q P S+ V+F ILK G + KW+ + G
Sbjct: 5335 KPGRQQAIPDST---VEFK--------AILK--------GTPPFKIKWFKDDVELVSGPK 5375
Query: 562 TIVGLKPETTY 572
+GL+ T++
Sbjct: 5376 CFIGLEGSTSF 5386
Score = 131 bits (329), Expect = 3e-30
Identities = 136/592 (22%), Positives = 237/592 (40%), Gaps = 34/592 (5%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
D+ P ++++GES F C V G A K I+W N E ++++V ++++TLT
Sbjct: 7215 DLKPVSVDLALGESGTFKCHVTGTAPIK-ITWAKDNREIRPGGNYKMTLV---ENTATLT 7270
Query: 83 IYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
+ DAG Y C + G +S A + V+ + + K P+ + ++ E C +
Sbjct: 7271 VLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS-RIVKQDEFTRYECKI 7329
Query: 142 VSSLPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
S ++W ++ R V S L++ + D G Y CE A +
Sbjct: 7330 GGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASS 7389
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
++ V PP + + + + G V L C+ +G P +SW KD ++
Sbjct: 7390 STSLK--VKEPPIFRKKPHPIETLK--GADVHLECELQGTPPFHVSWYKDKREL---RSG 7442
Query: 261 EKYIFSDDS--SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+KY ++ + + I VD D EY C A N G + + A P+ + +
Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIS 7502
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+ ++V L G S+ W I E ++ + +++L ++
Sbjct: 7503 TVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRE----SDNIWISYSENIATLQFSRVEPA 7558
Query: 379 DAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
+AG+Y C N G L V + A ++ P ++ G+ + C V P +
Sbjct: 7559 NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTK 7618
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
WF+DG+ L S N I +N S L++ + +D G Y+ N +G++S L +
Sbjct: 7619 WFKDGKELTSDNKYKISFFN--KVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVS 7676
Query: 498 DTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D PS + + S ++ V E + G PI W G E+ + Y
Sbjct: 7677 DRTVPPSFTRKLKETNGLSGSSVVM--ECKVYGSPPI---SVSWFHEGNEISSGRKYQTT 7731
Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP--VHSPPP 603
+T+ L+ + A N G E SA + P V P P
Sbjct: 7732 LTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDP 7783
Score = 129 bits (323), Expect = 1e-29
Identities = 111/481 (23%), Positives = 209/481 (43%), Gaps = 37/481 (7%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GES C+++G + K +SWF + E + +S + +S + LTI A+ +D+G
Sbjct: 6379 GESIQLECKISGSPEIK-VSWFRNDSELHESWKYNMSFI---NSVALLTINEASAEDSGD 6434
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G S +T + + +F P+P +G D ++ C++ + P ++W
Sbjct: 6435 YICEAHNGVGDASCSTA-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493
Query: 154 KGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
+ V + +F + S ++ L I ++ +D G Y C+ A E+ V
Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCK----ATNEVGSDTCSCSVKF 6547
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
+ + + + + +G +V L EGF ++ W KD ++ +E ++ + F D+ +
Sbjct: 6548 KEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIA 6607
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L + + ++ +YIC +N AG ++ + L V +I + L C
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECV 6667
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
+G P S W R +S++ K H + + +V+SL + + +D G Y N+
Sbjct: 6668 VTGTPELSAKWFKDGRELSADSK----HHITFIN-KVASLKIPCAEMSDKGLYSFEVKNS 6722
Query: 391 IGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
+G+ + ++ + V + KL+ A+ G V + C V ++ WF+DG
Sbjct: 6723 VGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL---GASVVLECRVSGSAPISVGWFQDGN 6779
Query: 444 LL---PSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
+ P S + T + S LE +D G Y C A N G + +L + P
Sbjct: 6780 EIVSGPKCQSSFSENVCTLNLSLLE-----PSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834
Query: 501 S 501
S
Sbjct: 6835 S 6835
Score = 128 bits (322), Expect = 2e-29
Identities = 131/598 (21%), Positives = 222/598 (37%), Gaps = 50/598 (8%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I WF + E ++ + I + + S+S L +Y+ + G Y C VT + GS+S T+
Sbjct: 5361 IKWFKDDVELVSGPKCFIGL---EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-S 170
+ K + + G+ + + C + S ++W ++ R + S
Sbjct: 5418 LVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDS 5477
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
+Q+ + D G + CE + A +VIV PP + IV N
Sbjct: 5478 VAVIQMNNLSTEDSGDFICEAQNPAGS--TSCSTKVIVKEPPVFSSFPPIVETLKN--AE 5533
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
V+L C+ G P + W KD Q+ + K + + + I VD +D EY C A+
Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISS 350
N+ G +K+ P+ N + E L G + W +
Sbjct: 5593 NEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652
Query: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS---MYLEVQYAPK 407
E + + V V++L + +AG+YIC N G M LE +
Sbjct: 5653 ESENIRITFV----ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVE 5708
Query: 408 LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
GP+ V G + C+V P ++ W++DG+LL SS YN S L +
Sbjct: 5709 KAGPMTVTV--GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN--KISSLRIL 5764
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
D G Y N +G+ S ++ +D PS + + TGG
Sbjct: 5765 SVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTR-------------RLKNTGG 5811
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYA-----VRLAALNGK 582
V E + G W+ K + G K +TT++ ++L +L+
Sbjct: 5812 VLGASCILECKVAGSSPISVAWFHEKTK------IVSGAKYQTTFSDNVCTLQLNSLDSS 5865
Query: 583 GLGEIS------AASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK 634
+G + A S+ + PP+ P+ + P + T P K
Sbjct: 5866 DMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFK 5923
Score = 127 bits (319), Expect = 4e-29
Identities = 103/483 (21%), Positives = 208/483 (43%), Gaps = 35/483 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ G+S C++AG + + + WF E ++ R++ + DS + + + N + +D
Sbjct: 5435 VKAGDSSRLECKIAGSPEIR-VVWFRNEHELPASDKYRMTFI---DSVAVIQMNNLSTED 5490
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
+G + C GS S +T V + + +F + P E + + + C++ + P ++
Sbjct: 5491 SGDFICEAQNPAGSTSCST-KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549
Query: 151 WKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
W R L+ ++ + S N+ + I + +D G Y C+ A+ E+
Sbjct: 5550 WYKDKRQ--LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCK----AQNEVGSDTCVCT 5603
Query: 208 VNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
V + PP ++ N + A G+ L EG + W K+ E++ +E ++ + F
Sbjct: 5604 VKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
++ + L K + + +YIC +N G ++ L V I + + E
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETC 5721
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
TL C+ +G P S+ W + ++S +K + ++SSL + S++ DAG Y
Sbjct: 5722 TLECKVAGTPELSVEWYKDGKLLTSSQK-----HKFSFYNKISSLRILSVERQDAGTYTF 5776
Query: 386 TASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
N +G+ S + ++V + +L+ V G + C+V +++W
Sbjct: 5777 QVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL---GASCILECKVAGSSPISVAW 5833
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
F + + S + + + + L++ +D GNY C A N G + +L +
Sbjct: 5834 FHEKTKIVSG--AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Query: 499 TPS 501
PS
Sbjct: 5892 PPS 5894
Score = 126 bits (316), Expect = 9e-29
Identities = 119/475 (25%), Positives = 200/475 (42%), Gaps = 26/475 (5%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GES C++ G + ++WF N E N R+ V +S + L I + ++D+G
Sbjct: 3752 GESARLHCKLKGSPVIQ-VTWFKNNKELSESNTVRMYFV---NSEAILDITDVKVEDSGS 3807
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C + GS+S +T + I + F P + G +A++ C+V + P I W
Sbjct: 3808 YSCEAVNDVGSDSCST-EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFK 3866
Query: 154 KGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV--IVNV 210
+ + K R F S L+I D G Y C + E+ ++
Sbjct: 3867 DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC----VVANEVGKCGCMATHLLKE 3922
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPT + + + A GQ+VTL G +++W K G+++ +E+ K FS+ +
Sbjct: 3923 PPTFVKKVDDLIALG--GQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFSNGVA 3979
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L I V + +Y C+AEN+AG Q + L V KI + + TL
Sbjct: 3980 VLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
+G P W R + + +K + V+ L S + D+G+Y SN
Sbjct: 4040 VAGTPELKPKWYKDGRPLVASKK-----YRISFKNNVAQLKFYSAELHDSGQYTFEISNE 4094
Query: 391 IGQDS---QSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
+G S L+ AP P+ V + + C++ +SWF+DG+ +
Sbjct: 4095 VGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA 4154
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
+S+ +I + LE+ ND GN+ C A N +G + L+ + PS
Sbjct: 4155 ASD--RYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPS 4207
Score = 124 bits (310), Expect = 4e-28
Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 26/469 (5%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E +VG+S CQVAG + +SW+ KL P + + N + +TL NI+
Sbjct: 6089 EAAVGDSVSLQCQVAG-TPEITVSWYK-GDTKLRPTPEYRTYFTN--NVATLVFNKVNIN 6144
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVVSSLP 146
D+G Y C G+ S TV +I ++ + F E G + C + S P
Sbjct: 6145 DSGEYTCKAENSIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAP 6203
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD---EGTYRCE-GRILARGEINFK 202
+ W G V+L+ D + + I +TD G Y C L + +
Sbjct: 6204 IQVCWYRDG--VLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSAR 6261
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
P + ++ A G+S C G ++W+KD ++I + +
Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKEI-RPGGNYT 6318
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK-ITYVENQTAMEL 321
++ L I KV K D +Y C A N G+ + L V PK + +E +
Sbjct: 6319 ITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ 6378
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
E + L C+ SG P ++W RN S ++ +M + V+ LT+ D+G
Sbjct: 6379 GESIQLECKISGSPEIKVSW---FRNDSELHESWKYNMSFIN--SVALLTINEASAEDSG 6433
Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440
+YIC A N +G S S L V+ P Q P V +G+ V + CE+ P + W +
Sbjct: 6434 DYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
D + + N KI + + L + +D G Y+C A N +G ++
Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540
Score = 120 bits (301), Expect = 5e-27
Identities = 127/548 (23%), Positives = 216/548 (39%), Gaps = 41/548 (7%)
Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
+G S C+V+G A + WF E ++ + + S ++ TL + D G
Sbjct: 6754 LGASVVLECRVSGSAPIS-VGWFQDGNEIVSGPKCQSSF---SENVCTLNLSLLEPSDTG 6809
Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
IY CV GS+ E + + + + F+ P E G V+ PP +
Sbjct: 6810 IYTCVAANVAGSD-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVIRGTPPFKVKW 6867
Query: 153 HKGRDVILKKDVRFIVLSN--NYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIV 208
KG ++ + I L + L++ ++ + G Y C L + + V
Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSC----LVTNDAGSASCTTHLFV 6923
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P T R + + + G + L G P ++SW KD I Q E ++
Sbjct: 6924 KEPATFVKR--LADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS-ITMTEK 6980
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
S+ L I + D A+Y C+ EN+AG+ + V P + E TL
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQ 7040
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
C+ G P I+W + S ++ V+SL + + ++D GEY C A
Sbjct: 7041 CKVDGTPEIRISWYKEHTKLRSAPA-----YKMQFKNNVASLVINKVDHSDVGEYSCKAD 7095
Query: 389 NTIGQDSQSMYLEVQ-------YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
N++G + S L ++ +A KL+ V+ G V C + +SW++D
Sbjct: 7096 NSVGAVASSAVLVIKARKLPPFFARKLKD---VHETLGFPVAFECRINGSEPLQVSWYKD 7152
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADT 499
G LL +N++ + + L++ ++ G YNC+A N +G S + IL + +
Sbjct: 7153 GVLLKDD--ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEV 7210
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + V + + + TG PI K W E+ Y K +E
Sbjct: 7211 PPFFDLKPVSVDLALGESGTFKCHVTGTAPI---KITWAKDNREIRPGGNY--KMTLVEN 7265
Query: 560 IVTIVGLK 567
T+ LK
Sbjct: 7266 TATLTVLK 7273
Score = 119 bits (298), Expect = 1e-26
Identities = 121/537 (22%), Positives = 204/537 (37%), Gaps = 38/537 (7%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
+ + L I N+ DAG Y C + E G + + V + F P E G+
Sbjct: 6038 EKTCILEILNSTKRDAGQYSCEIENEAGRDVCGAL-VSTLEPPYFVTELEPLEAAVGDSV 6096
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRI 193
+ C V + T+ W +KG + +NN L + D G Y C+
Sbjct: 6097 SLQCQVAGTPEITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK--- 6152
Query: 194 LARGEINFKDIQVIVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
A I + + + PP+ + + T +G VTL C G + W
Sbjct: 6153 -AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWY 6209
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+DG + +E+ + F D+ + L I + D + +Y C A N G ++ L
Sbjct: 6210 RDGVLLRDDENLQTS-FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPK 6268
Query: 309 KITYVENQTA---MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
K + + + + E C +G ITW + I G+ +
Sbjct: 6269 KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRP-----GGNYTITCVG 6323
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVAVYTWEGNQVN 423
L + + D+G+Y C A+N +G+D S L V+ PK + + +G +
Sbjct: 6324 NTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQ 6383
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483
+ C++ P +SWFR+ L S N+ N S + L + S D G+Y C A N
Sbjct: 6384 LECKISGSPEIKVSWFRNDSELHESWKYNMSFIN--SVALLTINEASAEDSGDYICEAHN 6441
Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD---EPEATGGVPILKYKAEWRAV 540
+G S L T +P + +P A D + E +G P ++ W
Sbjct: 6442 GVGDASCSTAL----TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPP---FEVVWVKD 6494
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
++V +SK + + + I+ L+ A N G S + +FK P
Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPP 6551
Score = 117 bits (292), Expect = 5e-26
Identities = 123/517 (23%), Positives = 201/517 (38%), Gaps = 33/517 (6%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+++G ++ W+ + + + +I+ + + +++ I N + D G Y C
Sbjct: 5538 CELSG-TPPFEVVWYKDKRQLRSSKKYKIA---SKNFHTSIHILNVDTSDIGEYHCKAQN 5593
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
E GS++ VK+ + F + GE A + + + P + W + +VI
Sbjct: 5594 EVGSDT-CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652
Query: 161 KKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
+ + I N LQ + + G Y C+ I G + ++V P I +
Sbjct: 5653 ESENIRITFVENVATLQFAKAEPANAGKYICQ--IKNDGGMRENMATLMVLEPAVIVEKA 5710
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ T +G++ TL C G PE ++ W KDG+ + + K+ F + S L I V+
Sbjct: 5711 GPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQK-HKFSFYNKISSLRILSVE 5767
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAK---PKITYVENQTAMELEEQVTLTCEASGDP 335
+ D Y +N G+ T + V + P T T L L C+ +G
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827
Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
S+ W I S K V +L L S+ +D G Y C A+N G D
Sbjct: 5828 PISVAWFHEKTKIVSGAK-----YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDE 5882
Query: 396 QSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
L VQ P ++ P + G V T + P ++WFR + L + NI
Sbjct: 5883 CRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNI- 5941
Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE---FILVQADTPSSPSIDQVEPY 511
Y + + LE+ + G Y C N GQ S F+ A S VEP
Sbjct: 5942 -YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPG 6000
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548
S E TG +PI W+ G + S+
Sbjct: 6001 KSIIL----ESTYTGTLPI---SVTWKKDGFNITTSE 6030
Score = 115 bits (287), Expect = 2e-25
Identities = 137/589 (23%), Positives = 224/589 (38%), Gaps = 30/589 (5%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
DI P ++ GES F C V G A+ I+W N E I+ V N + L
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTG-AQPMRITWSKDNKEIRPGGNYTITCVGN---TPHLR 6329
Query: 83 IYNANIDDAGIYKCVVTGEDGSE-SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
I D+G Y C T + G + A ++VK K + K + ++GE + C +
Sbjct: 6330 ILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFV-KKLEASKVAKQGESIQLECKI 6388
Query: 142 VSSLPPTIIWKHKGRDV--ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
S + W ++ K ++ FI S L I D G Y CE G+
Sbjct: 6389 SGSPEIKVSWFRNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAH-NGVGDA 6446
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + V PP + + V A G V L C+ G P + W KD +Q+ +
Sbjct: 6447 SC-STALTVKAPPVFTQKPSPVGALK--GSDVILQCEISGTPPFEVVWVKDRKQVRNSK- 6502
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
K + L I ++ +D EY C A N+ G + +K P+ + T+
Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTST 6562
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ + V L G S+ W + E + + +++L L S + ++
Sbjct: 6563 LIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI----DNIATLQLGSPEASN 6618
Query: 380 AGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
+G+YIC N G S L V + A ++ P + GN + C V P + W
Sbjct: 6619 SGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW 6678
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
F+DG+ L + + +I N + L++ +D G Y+ N +G+ + + +D
Sbjct: 6679 FKDGRELSADSKHHITFIN--KVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736
Query: 499 TPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
PS + V + V E +G PI W G E+ +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVL--ECRVSGSAPI---SVGWFQDGNEIVSGPKCQSSF 6791
Query: 555 ASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
+ + + L+P T A N G E SA + P P
Sbjct: 6792 SENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTP 6840
Score = 112 bits (279), Expect = 2e-24
Identities = 124/562 (22%), Positives = 218/562 (38%), Gaps = 44/562 (7%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C++AG + +SWF E ++ RI+ V + +++L I +++DAG + C T
Sbjct: 4134 CKIAGSLPMR-VSWFKDGKEIAASDRYRIAFV---EGTASLEIIRVDMNDAGNFTCRATN 4189
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
GS+ + + + + F P ++ G + S P TI W KG ++
Sbjct: 4190 SVGSKDSSGALI-VQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW-FKGNKELV 4247
Query: 161 KKDVRFIVLS--NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
+I + L++ +K +D GTY C+ +A G ++ V P T +
Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL--FVKEPATFVEKL 4305
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ G + L C G P ++W + +I+ E + F + ++ L + V
Sbjct: 4306 E-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIK-ESSKHRMSFVESTAVLRLTDVG 4363
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
D EY+C A+N+AG + + V P T + E V L E +G P
Sbjct: 4364 IEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFE 4423
Query: 339 ITW---RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
ITW T R+ + + H+V SL + DAGEY C +N +G
Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLV--------SLQILKFVAADAGEYQCRVTNEVGSSI 4475
Query: 396 QSMYLEVQYAPKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
S + ++ P + + + G + T++W +D + + +
Sbjct: 4476 CSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMT 4535
Query: 455 IYNTPSASYL---EVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD----TPSSPSIDQ 507
N ++ YL EV D G Y C A N G + +L + T + SID
Sbjct: 4536 FENNVASLYLSGIEVKHD-----GKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDV 4590
Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567
+ +T QV+F + + A+W G+E+ Y I+ I+ +
Sbjct: 4591 TQGDPATLQVKFSGTK--------EITAKWFKDGQELTLGSKYKISVTDTVSILKIISTE 4642
Query: 568 PETTYAVRLAALNGKGLGEISA 589
+ + N G A
Sbjct: 4643 KKDSGEYTFEVQNDVGRSSCKA 4664
Score = 110 bits (275), Expect = 5e-24
Identities = 141/565 (24%), Positives = 226/565 (40%), Gaps = 65/565 (11%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
++SVG+S CQ+AG + +SW+ + KL P N+ +TL +I+
Sbjct: 7971 KVSVGDSASLQCQLAG-TPEIGVSWYKGD-TKLRPTTTYKMHFRNN--VATLVFNQVDIN 8026
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE--GEDAVIVCDVVSSLPP 147
D+G Y C G S +T QKL + ++ +E G V C + S P
Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDE---GTYRCEG-RILARGEINFKD 203
++ W G+ + +V+ L N I KTD G Y C + + +
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNT--ATLNIFKTDRSLAGQYSCTATNPIGSASSSARL 8144
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
I PP R V+A +G+S C G +SW KD +I KY
Sbjct: 8145 ILTEGKNPPFFDIRLAPVDAV--VGESADFECHVTGTQPIKVSWAKDSREIRS---GGKY 8199
Query: 264 IFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV---FAKPKITYVENQTA 318
S ++S+ LT+ KVDK D +Y C A N+ G+ T L + P T ++T
Sbjct: 8200 QISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETV 8259
Query: 319 MELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E E L +G ++ W + I + T + + +++ V L ++
Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKNNIEI---QPTSNCEITFKNNTLV--LQVRKAGM 8314
Query: 378 TDAGEYICTASNTIGQD--SQSMYLEVQYAPKL--QGPVAVYTWEGNQVNITCEVFAYPS 433
DAG Y C SN G + S+ ++ P + Q V EG V ++C V
Sbjct: 8315 NDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEP 8374
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I W + G+ + S+ + + LE+ ++ D G+Y C A N G ++ +
Sbjct: 8375 IRIQWLKAGREIKPSDRCSFSF--ASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSK 8432
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQ-----FDEPEA--------------TGGVPI--LK 532
+ D P+ V P + A V EP++ GG PI +K
Sbjct: 8433 VTIKDKPA------VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVK 8486
Query: 533 Y-KAEWRAV---GEEVWHSKWYDAK 553
+ K +WR + G H K +AK
Sbjct: 8487 WTKGKWRQLNQGGRVFIHQKGDEAK 8511
Score = 110 bits (274), Expect = 6e-24
Identities = 103/400 (25%), Positives = 162/400 (40%), Gaps = 41/400 (10%)
Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
VGES F C V G K +SW + E + + +IS + N S+ LT+ + D+G
Sbjct: 8166 VGESADFECHVTGTQPIK-VSWAKDSREIRSGGKYQISYLEN---SAHLTVLKVDKGDSG 8221
Query: 93 IYKCVVTGEDGSES-EATVNVK--IFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTI 149
Y C E G +S A +N+K + K E EG + V S P T+
Sbjct: 8222 QYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITV 8281
Query: 150 IWKHKGRDVILKKDVRFIVLSNN--YLQIRGIKKTDEGTYRCE-----GRILARGEINFK 202
W +K I I NN LQ+R D G Y C+ G L I K
Sbjct: 8282 AW-YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIK 8340
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
+ + PP Q++ T + G+ V L C +G + W K G +I+ D
Sbjct: 8341 EPKK----PPVFD--QHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPS-DRCS 8393
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT----------- 311
+ F+ ++ L ++ V K D +Y+C A N AG + + KP +
Sbjct: 8394 FSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGR 8453
Query: 312 --YVENQTAMELEEQVTLT--CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+V ++ + E+ T T + GDPIP++ W + G + +
Sbjct: 8454 LFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKG----KWRQLNQGGRVFIHQKGDE 8509
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK 407
+ L ++ TD+G Y C A N G+ ++ L+V K
Sbjct: 8510 AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKK 8549
Score = 106 bits (264), Expect = 9e-23
Identities = 129/590 (21%), Positives = 220/590 (37%), Gaps = 44/590 (7%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATV 110
++W + E + R++ +++ ++L + + G Y C + G + A +
Sbjct: 4517 VTWLKDSDEITEDDNIRMTF---ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+VK + + +G+ A + + T W G+++ L + V
Sbjct: 4574 SVK--EPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTD 4631
Query: 171 N-NYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNAT 224
+ L+I +K D G Y E GR + IN D+ + PP+ + +++
Sbjct: 4632 TVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLII----PPSFTKKLKKMDSI 4687
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
G + L C G ++ W KD ++I E K+ F D+++ L I +++ D
Sbjct: 4688 K--GSFIDLECIVAGSHPISIQWFKDDQEISASEK-YKFSFHDNTAFLEISQLEGTDSGT 4744
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Y C A NKAG + HL V P + +V L G +I W
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKD 4804
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
+ + S V +SL L + + TD+G YIC SN +G + L V+
Sbjct: 4805 NKELHS-----GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859
Query: 405 AP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461
P K PV V G C++ P +SW+ DG + + I +
Sbjct: 4860 PPQFIKKPSPVLVLR-NGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFID--GL 4916
Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD- 520
+ +++ + G Y C A N G S L + P+ I +++P +
Sbjct: 4917 ATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPT--FIRELKPVEVVKYSDVEL 4974
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
E E TG P ++ W E+ SK Y + + I P T + N
Sbjct: 4975 ECEVTGTPP---FEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSN 5031
Query: 581 GKGLGEISAASEFKTQPVH-------SPPPPASASSSTPVPLSPP-DTTW 622
G S K P + +SA+ + V SPP TW
Sbjct: 5032 EGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITW 5081
Score = 105 bits (261), Expect = 2e-22
Identities = 113/487 (23%), Positives = 192/487 (39%), Gaps = 51/487 (10%)
Query: 32 SVGESKFFLCQVAGDAKDKDISWFSPNGEKL--TPNQQRISVVWNDDSSSTLTIYNANID 89
+VG F C ++G ++ +SW+ +G+ L +PN Q + D+++TL I+ +
Sbjct: 8069 TVGLPVVFDCAISG-SEPISVSWYK-DGKPLKDSPNVQTSFL----DNTATLNIFKTDRS 8122
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPP 147
AG Y C T GS S + + K F P + GE A C V + P
Sbjct: 8123 LAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPI 8182
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNN-YLQIRGIKKTDEGTYRCE-----GRILARGEINF 201
+ W R++ + L N+ +L + + K D G Y C G+ ++N
Sbjct: 8183 KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI 8242
Query: 202 KDIQVIVNVPPTIQAR-QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K+ + PP+ R V T G S L G T++W K+ +I+ +
Sbjct: 8243 KERLI----PPSFTKRLSETVEETE--GNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNC 8296
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ---- 316
E F +++ L ++K ND Y C N AG T + V +PK V +Q
Sbjct: 8297 E-ITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI-VIKEPKKPPVFDQHLTP 8354
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
+ E V L+C G I W + R I ++ + + L L+ +
Sbjct: 8355 VTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFA-----SGTAVLELRDVA 8409
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKL----------------QGPVAVYTWEGN 420
D+G+Y+C ASN G D+ + ++ P + P ++ E
Sbjct: 8410 KADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKT 8469
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
+V P + W + G+ + + I+ + LE+ ++ D G Y C
Sbjct: 8470 TATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCV 8528
Query: 481 AVNRIGQ 487
A N G+
Sbjct: 8529 AFNEHGE 8535
Score = 102 bits (255), Expect = 1e-21
Identities = 102/449 (22%), Positives = 181/449 (40%), Gaps = 34/449 (7%)
Query: 52 ISWFSPNGEKLTPNQQ-RISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
+ W E + ++ RI+ V N +TL A +AG Y C + DG E
Sbjct: 5641 VQWLKEKEEVIRESENIRITFVEN---VATLQFAKAEPANAGKYICQIKN-DGGMRENMA 5696
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+ + + + P GE + C V + ++ W G+ + + +F +
Sbjct: 5697 TLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756
Query: 171 N-NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV-----PPTIQARQNIVNAT 224
+ L+I +++ D GTY + + + +V+V PP+ R + N
Sbjct: 5757 KISSLRILSVERQDAGTYTFQ----VQNNVGKSSCTAVVDVSDRAVPPSFTRR--LKNTG 5810
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDE 282
LG S L C G +++W + +I KY FSD+ L + +D +D
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVS---GAKYQTTFSDNVCTLQLNSLDSSDM 5867
Query: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSIT 340
Y C+A N AG + L V P ++V+ +E+ + VT T G P +
Sbjct: 5868 GNYTCVAANVAGSDECRAVLTVQEPP--SFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
W R + ++ + V+ L L +I + +GEY C SN GQ S + L
Sbjct: 5926 WFRGARELVKGDR-----CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL 5980
Query: 401 EVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
V+ ++ ++ E G + + +++W +DG + +S N I T
Sbjct: 5981 FVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCN--IVTTE 6038
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQE 488
LE+ ++ D G Y+C N G++
Sbjct: 6039 KTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 102 bits (253), Expect = 2e-21
Identities = 118/461 (25%), Positives = 182/461 (39%), Gaps = 31/461 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE-SEATV 110
+SW E L +R S+ + S+ L I + I+D Y C++ E G + EA V
Sbjct: 6958 VSWIKD--EYLISQSERCSITMTE-KSTILEILESTIEDYAQYSCLIENEAGQDICEALV 7014
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+V + F E GE A + C V + I W +K + +
Sbjct: 7015 SV--LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISW-YKEHTKLRSAPAYKMQFK 7071
Query: 171 NNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV--NVPPTIQARQNIVNATAN 226
NN L I + +D G Y C+ G + + VI +PP + V+ T
Sbjct: 7072 NNVASLVINKVDHSDVGEYSCKADNSV-GAVASSAVLVIKARKLPPFFARKLKDVHET-- 7128
Query: 227 LGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
LG V C G +SW KDG ++ + + + F + + L I + D++ +Y
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTS-FVHNVATLQILQTDQSHIGQYN 7187
Query: 287 CIAENKAGEQDATIHLKVF---AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343
C A N G ++ L + P + L E T C +G ITW
Sbjct: 7188 CSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAK 7247
Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
R I G+ + ++LT+ + DAG+Y C ASN G+DS S L VQ
Sbjct: 7248 DNREIRP-----GGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ 7302
Query: 404 YAP----KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
P KL+ V E + C++ P + W++D + S S ++
Sbjct: 7303 EPPRFIKKLEPSRIVKQDEFTRYE--CKIGGSPEIKVLWYKDETEIQES--SKFRMSFVD 7358
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
S + LE+ S D G+Y C A N G S L + P
Sbjct: 7359 SVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399
Score = 100 bits (248), Expect = 7e-21
Identities = 155/625 (24%), Positives = 236/625 (37%), Gaps = 94/625 (15%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E+ V E + + + + D D W+ E Q+R V + + I
Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQS 3213
Query: 90 DAGIYKCVVTGEDGSESEATVNV----KIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSL 145
DAG Y V G + S VN ++ Q+L P + G+ A C V+S
Sbjct: 3214 DAGEYT-FVAGRNRSSVTLYVNAPEPPQVLQELQ------PVTVQSGKPARF-CAVISGR 3265
Query: 146 P-PTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGR---------- 192
P P I W + + + +F+ Y L I + D Y CE +
Sbjct: 3266 PQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE-DAAVYTCEAKNDYGVATTSA 3324
Query: 193 --ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+ E+ D ++ V P I Q+ V + GQ C G + +SW
Sbjct: 3325 SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSE---GQPARFQCRVSG-TDLKVSWYSK 3380
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
++I+ F +D+ QL I + DE Y +A N G+ +T +L + A I
Sbjct: 3381 DKKIKPSRFFRMTQF-EDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESI 3439
Query: 311 TY--VENQTAMELEEQVTL-----------------TCEASGDPIPSITWRTSTRNISSE 351
+ +E + ME++ + TCE P W + R I
Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499
Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAPK-L 408
+K +RS +SSL + Q D GEY C ASN G S + L V Y P L
Sbjct: 3500 DKCS-----IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFL 3554
Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVT 467
P ++ T+ G C V P W +DG L PS N+ +I + + LE++
Sbjct: 3555 SRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW---RISDAENKHILELS 3611
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST------AQVQFDE 521
+ D G Y+C A N+ G + + L+ D P I ++EP S + Q DE
Sbjct: 3612 NLTIQDRGVYSCKASNKFGADICQAELIIIDKPH--FIKELEPVQSAINKKVHLECQVDE 3669
Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWY----DAKEASMEGIVTIVGLKPETTYAVRLA 577
K W G+++ K Y + K A++E + + LK TY
Sbjct: 3670 DR--------KVTVTWSKDGQKLPPGKDYKICFEDKIATLE--IPLAKLKDSGTYV--CT 3717
Query: 578 ALNGKGLGEISAASEFKTQPVHSPP 602
A N G SA T V PP
Sbjct: 3718 ASNEAGSSSCSA-----TVTVREPP 3737
Score = 98.2 bits (243), Expect = 2e-20
Identities = 131/599 (21%), Positives = 224/599 (37%), Gaps = 68/599 (11%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C V ISW+ E+L + + +D TL + A +DA +Y C
Sbjct: 3259 CAVISGRPQPKISWYKE--EQLLSTGFKCKFL-HDGQEYTLLLIEAFPEDAAVYTCEAKN 3315
Query: 101 EDG-SESEATVNVKIFQKLM-FKNAP-------TPQE---FREGEDAVIVCDVVSSLPPT 148
+ G + + A+++V++ + + + P TP + EG+ A C V S
Sbjct: 3316 DYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV-SGTDLK 3374
Query: 149 IIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTY-----RCEGRILARGEINFK 202
+ W K + + + R + Y L+I DEGTY G++ + ++ +
Sbjct: 3375 VSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 3434
Query: 203 ------------DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+I++ + P I ++ I LG C+ + P W K
Sbjct: 3435 APESILHERIEQEIEMEMKAAPVI--KRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 3492
Query: 251 GEQIEQEED----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
G +I + + KYI S L I + D EY C A N+ G T L V
Sbjct: 3493 GREIYESDKCSIRSSKYI-----SSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE 3547
Query: 307 KPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
T++ ++ + + C +G P+ W+ +S +
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHI 3607
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVN 423
+S+LT++ D G Y C ASN G D Q+ + + ++ V + +V+
Sbjct: 3608 LELSNLTIQ-----DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVH 3662
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483
+ C+V T++W +DGQ LP + KI + LE+ D G Y CTA N
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720
Query: 484 RIGQESLEFILVQADTPS-----SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
G S + + PS PS + S+ + G P++ + W
Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLK------GSPVI--QVTWF 3772
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+E+ S + E I+ I +K E + + A+N G S K P
Sbjct: 3773 KNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP 3831
Score = 90.5 bits (223), Expect = 5e-18
Identities = 156/714 (21%), Positives = 270/714 (37%), Gaps = 95/714 (13%)
Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
F C+V + + WF N E + + + I + D TL I +A++DD Y +
Sbjct: 12659 FNCEV--NTEGAKAKWFR-NEEAIFDSSKYI--ILQKDLVYTLRIRDAHLDDQANYNVSL 12713
Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQ-EFREGEDAVIVCDVVSSLPPTIIWKHKGRD 157
T G ++ N+ + ++ + P E E + C V + L T+ W G +
Sbjct: 12714 TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE 12772
Query: 158 VILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA 216
V V + V + L I+ DEG Y I+ G+ K + ++ + +
Sbjct: 12773 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEY-----IVTAGQD--KSVAELLIIEAPTEF 12825
Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS--QLTI 274
+++ + T C + + W ++G +I++ +KY F D S +L I
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKE---GKKYKFEKDGSIHRLII 12881
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE---QVTLTCEA 331
K +DE EY C G +D ++F + + LE V E
Sbjct: 12882 KDCRLDDECEYAC------GVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAEL 12935
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391
+ D + + W + + +K H ++ S ++ L + I+ D GEY I
Sbjct: 12936 NKDKV-EVQWLRNNMVVVQGDK----HQMM-SEGKIHRLQICDIKPRDQGEY-----RFI 12984
Query: 392 GQDSQSMY-LEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
+D ++ LE+ APK++ + G + + AYP A WF++ + L +
Sbjct: 12985 AKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKT 13044
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP-SIDQV 508
I T + + + D G Y N+ G+ L D P +++
Sbjct: 13045 -----IDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVT 13099
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL-K 567
E + + ++EP GG I+ Y E R ++ W A + + T+ GL K
Sbjct: 13100 ETFDGEVSLAWEEPLTDGGSKIIGYVVERR----DIKRKTWVLATDRAESCEFTVTGLQK 13155
Query: 568 PETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPAL 627
Y R++A N G GE PV + P A S VP P + T
Sbjct: 13156 GGVEYLFRVSARNRVGTGE----------PVET-DNPVEARSKYDVPGPPLNVTI----- 13199
Query: 628 ATTEPAKGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSS-EWKP 683
D N V+L + DGG+ I +Y++ R +S W
Sbjct: 13200 --------------------TDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDT 13239
Query: 684 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK-AAHFVFRTSAQPTAIPA 736
+ + + + + EY V A+N+ G K +A F A P P+
Sbjct: 13240 AMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPS 13293
Score = 86.7 bits (213), Expect = 8e-17
Identities = 85/329 (25%), Positives = 123/329 (37%), Gaps = 48/329 (14%)
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 452
Q++ ++L+V KL + V G ++ + V P I+W + +L
Sbjct: 13685 QEAPEIFLDV----KLLAGLTVKA--GTKIELPATVTGKPEPKITWTKADMILKQDK--R 13736
Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS-IDQVEPY 511
I I N P S + + +D G Y AVN G+ + + D P P+ D +
Sbjct: 13737 ITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVT 13796
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETT 571
+ + + ++ P GG I Y E RA EVWH K+ + + I P
Sbjct: 13797 NESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLI----PNKE 13852
Query: 572 YAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTE 631
Y R+AA N G+GE AS + PP P P L P D T L E
Sbjct: 13853 YIFRVAAENMYGVGEPVQASPITAKYQFDPPGP-------PTRLEPSDITKDAVTLTWCE 13905
Query: 632 PAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPSG 690
P DDGGSPI Y V R + +W ++P
Sbjct: 13906 P---------------------------DDDGGSPITGYWVERLDPDTDKWVRCNKMPVK 13938
Query: 691 SDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
+K L +Y V+AEN G K
Sbjct: 13939 DTTYRVKGLTNKKKYRFRVLAENLAGPGK 13967
Score = 84.7 bits (208), Expect = 3e-16
Identities = 70/266 (26%), Positives = 112/266 (42%), Gaps = 41/266 (15%)
Query: 174 LQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVN-----VPPTIQARQN---- 219
L ++ I K D+GTYRC+ G + E+ K ++ + + I+ R +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 220 ----------IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
+ N TA +G++V PEP ++W K G++I+ ++D+KY F D
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 270 S--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT----------YVENQT 317
QLTI V +D+AEY +A NK GE L V P T + N
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E + V SG P P++ W + +S ++ +L ++
Sbjct: 31806 CQE-GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI----EIIHEGLDYYALHIRDTLP 31860
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQ 403
D G Y TA+NT G S +L+V+
Sbjct: 31861 EDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 80.5 bits (197), Expect = 5e-15
Identities = 84/399 (21%), Positives = 168/399 (42%), Gaps = 33/399 (8%)
Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-RISVVWNDDSSS 79
++ +Q I+ G+ +AG D+ W NG +LT +++ R V +D
Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAGAT---DVKWVL-NGVELTNSEEYRYGVSGSDQ--- 33092
Query: 80 TLTIYNANIDDAGIYKCVVTGEDG---SESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
TLTI A+ D GI C+ ++G + + T++ ++ F + P Q EG++ +
Sbjct: 33093 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVL 33152
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA 195
C++ P I W + + +V N Y L+IR +D G Y + +
Sbjct: 33153 FTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNF- 33211
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATAN--------LGQSVTLVCDAEGFPEPTMSW 247
RG+ + ++ +P + + +V T+ QSV + + E + S
Sbjct: 33212 RGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQ---EASFSS 33266
Query: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
E + + S + V+ + + ++ I+ E + LK +
Sbjct: 33267 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMS-SSSFMGISNMTQLESSTSKMLKAGIR 33325
Query: 308 ---PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
PKI + + +++ + +T+ C +G+P P +TW R I S+E+ G + +
Sbjct: 33326 GIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ---GRFHIENT 33382
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
+++L + +Q D G Y + N G DS ++ + ++
Sbjct: 33383 DDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 80.1 bits (196), Expect = 7e-15
Identities = 100/440 (22%), Positives = 161/440 (36%), Gaps = 75/440 (17%)
Query: 315 NQTAMELEEQVTLTCEASGDPIPS--ITWRTSTRNISS---EEKTLDG---------HMV 360
N+ + L + T + S P+P +T TRN ++ E+ DG M
Sbjct: 25276 NEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQ 25335
Query: 361 VRSHARVSSLT-LKSIQYTDAG-----EYI--CTASNTIGQDSQSMY------LEVQYAP 406
+ + S+ T +K+++ T +G EY+ A N G+ +++ P
Sbjct: 25336 TKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP 25395
Query: 407 KLQGPVAVYTWEGN-QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465
++ P + + Q+ I P AT++W +DGQ L + N+ T ++ L
Sbjct: 25396 SVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS--LS 25453
Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS---IDQVEPYSSTAQVQFDEP 522
+ S+ D G Y N G ++ ++ D P P ID+V S T + ++ P
Sbjct: 25454 IKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSIT--ISWNPP 25511
Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582
E GG I Y E + WH +A + IV L + Y R+ A N
Sbjct: 25512 EYDGGCQISNYIVEKKETTSTTWHI----VSQAVARTSIKIVRLTTGSEYQFRVCAENRY 25567
Query: 583 GLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKL 642
G S +S + SPP P S TW +P
Sbjct: 25568 GKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPV---------------- 25611
Query: 643 EGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDW 701
+DGGS + Y + Y+ SS W ++ + + LD
Sbjct: 25612 ------------------NDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDE 25653
Query: 702 NAEYEVYVVAENQQGKSKAA 721
YE V AEN G K +
Sbjct: 25654 GLMYEYRVYAENIAGIGKCS 25673
Score = 80.1 bits (196), Expect = 7e-15
Identities = 92/397 (23%), Positives = 162/397 (40%), Gaps = 38/397 (9%)
Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTI 274
R+ + + T LG++ L C G P P + W + G+++ Q KY S D + LT+
Sbjct: 30536 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ---SRKYKMSSDGRTHTLTV 30592
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI---TYVENQTAMELEEQVTLTCEA 331
++ DE Y CIA N+ GE + + L + A P+ ++ + + + L
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ-YTDAGEYICTASNT 390
G P+P++TW + + + E ++ + + + L +K++Q T AG+Y SN
Sbjct: 30653 IGRPVPAMTWFHGQKLLQNSE-----NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNV 30707
Query: 391 IGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWF---------- 439
G + +E+Q P K GP+ + N I+ + A SW
Sbjct: 30708 FGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGG--SWITNYVVEKCEA 30765
Query: 440 ---RDGQLLPSS-NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ QL+ S+ + + +I N + ++N FG + V+ + ++
Sbjct: 30766 KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFE 30823
Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+ P P+I V + V + P + GG I Y E R + W S E
Sbjct: 30824 KPGAPGKPTITAVT--KDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISV---TTEE 30878
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
E + ++ L Y R+ N G E S SE
Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 30915
Score = 79.0 bits (193), Expect = 2e-14
Identities = 69/287 (24%), Positives = 126/287 (43%), Gaps = 19/287 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE-SEATV 110
++W+ N E + I+ +++ L + A ++DAG+Y C V+ + GS +++
Sbjct: 8281 VAWYKNNIEIQPTSNCEITF---KNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI 8337
Query: 111 NVKIFQKL-MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL 169
+K +K +F TP EGE + C V S P I W GR++ F
Sbjct: 8338 VIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFA 8397
Query: 170 SNN-YLQIRGIKKTDEGTYRCEGRILA-----RGEINFKDIQVIVNVPP--TIQARQNIV 221
S L++R + K D G Y C+ +A + ++ KD + + R V
Sbjct: 8398 SGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFV 8457
Query: 222 NATANLG----QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD-DSSQLTIKK 276
+ ++ + T + G P P + WTK G+ + + +I D ++L I+
Sbjct: 8458 SEPQSIRVVEKTTATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRD 8516
Query: 277 VDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
K D Y C+A N+ GE ++ ++L+V + K +E L++
Sbjct: 8517 TTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKK 8563
Score = 78.2 bits (191), Expect = 3e-14
Identities = 145/635 (22%), Positives = 245/635 (38%), Gaps = 104/635 (16%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
DS STLT+ N N +DAG Y V GS+S T VK+ P P F++
Sbjct: 28408 DSFSTLTVENCNRNDAGKYTLTVENNSGSKS-ITFTVKVLDT---PGPPGPITFKD---- 28459
Query: 136 VIVCDVVSSLPPTIIWKHKGRD--------VILKKDVRF----IVLSNNYLQIRGIKKTD 183
V+ T++W D V+ K++ ++ QI +
Sbjct: 28460 ------VTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLA 28513
Query: 184 EGT---YRCEG-RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEG 239
EG +R GE ++ P R ++V+ + + L D +G
Sbjct: 28514 EGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDG 28573
Query: 240 FPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAG-- 294
T G +E +++ + ++ + + QLT ++++ + E E+ A+N AG
Sbjct: 28574 GSRIT------GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYS 28627
Query: 295 EQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA----------SGDPIPSITWRTS 344
E + +P+I + T + + +TC+A SG P P +TW+
Sbjct: 28628 EPREAFSSVIIKEPQIEPTADLTGITNQ---LITCKAGSPFTIDVPISGRPAPKVTWKLE 28684
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
+ ++ + + + ++LT+K D+G Y T NT G + S+ + V
Sbjct: 28685 EMRLKETDR-----VSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 28739
Query: 405 AP-KLQGPV---------AVYTW----EGNQVNITCEVF-AYPSATISWFRDGQLLPSSN 449
P + GP+ V +W +G IT + S T +W L +S+
Sbjct: 28740 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW-----QLVNSS 28794
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQAD----TPSSPS 504
+I T Y+E ++ ++ NR G + LE + A+ PS+P+
Sbjct: 28795 VKRTQIKVTHLTKYMEY---------SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPT 28845
Query: 505 IDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 563
+V S+ A ++++EP GG I+ Y E + +W + K +E +
Sbjct: 28846 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVK---ENKVPCLECNYKV 28902
Query: 564 VGLKPETTYAVRLAALNGKGLGEISAASE--FKTQPVHSPPPPASASSSTPVPLSPPDTT 621
GL Y R ALN G+ + S AS PV +P P T V S
Sbjct: 28903 TGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRP----EVTDVTRSTVSLI 28958
Query: 622 WPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
W PA G K ++G DG +K N
Sbjct: 28959 WSAPAYDGGSKVVGYIIERKPVSEVG-DGRWLKCN 28992
Score = 76.3 bits (186), Expect = 1e-13
Identities = 111/520 (21%), Positives = 189/520 (36%), Gaps = 72/520 (13%)
Query: 50 KDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE---- 105
K+++W+ +G+KL N ++ D + L I N D G Y C ++GE G+
Sbjct: 32747 KEVTWYK-DGKKLKENGH-FQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 32804
Query: 106 ---------------------------SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+E+TV K K + P +D +
Sbjct: 32805 QFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVS 32864
Query: 139 CDVVSSLP--------PTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRC 189
D V+ PT IW G+ + + + L+I +D G Y C
Sbjct: 32865 SDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTC 32924
Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE------GFPEP 243
+ A G ++ ++ + +A++ T+ + V E E
Sbjct: 32925 TVKNSA-GSVS-SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEI 32982
Query: 244 TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303
MS K E++ +E+ K + S++ + ++K+ E I + E +K
Sbjct: 32983 KMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIK 33042
Query: 304 VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
F+ T M + E L +A+ + W + +++ E+ G
Sbjct: 33043 AFS----------TQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYG-----V 33087
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPK-LQGPVAVYTWE 418
+LT+K + D G C + G Q ++ E+ AP + P + E
Sbjct: 33088 SGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINE 33147
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V TCE+ PS I WF++ LP S SN+ I + + LE+ S +D G Y
Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNN--LPISISSNVSISRSRNVYSLEIRNASVSDSGKYT 33205
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518
A N GQ S L+ PS + V S +Q
Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQ 33245
Score = 74.7 bits (182), Expect = 3e-13
Identities = 110/476 (23%), Positives = 180/476 (37%), Gaps = 78/476 (16%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKIT-YVENQTAMELEE--QV 325
Q T++ + + E E+ A N AG + AT+ +P + ++ + ME+EE V
Sbjct: 16075 QFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNV 16134
Query: 326 TLTCEASGDPIPSITW-RTSTRNISSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEY 383
+ + G P P++TW + + ++E L D H+ +L + + +D G Y
Sbjct: 16135 NIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWF--R 440
TA N +G S+ M L V P GP+ + +Q+ T+SWF +
Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQM------------TLSWFPPK 16242
Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---- 486
D +NY + + + + P + E + A N+ G
Sbjct: 16243 DDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEP 16302
Query: 487 ----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542
E+ + P P++ V S T V ++EPE GG P+ Y E +
Sbjct: 16303 LDSEPETARNLFSVPGAPDKPTVSSVTRNSMT--VNWEEPEYDGGSPVTGYWLEMKDTTS 16360
Query: 543 EVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSP 601
+ W D +A G+ + GL + Y R+ A+N G+G P P
Sbjct: 16361 KRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVG-----------PASLP 16409
Query: 602 PPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQD 661
PA+A P++PP +P T A E S P
Sbjct: 16410 SDPATARD----PIAPPGPPFPKVTDWTKSSADLEWSPP-------------------LK 16446
Query: 662 DGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
DGGS + Y+V Y+ EW+ +++ L A Y+ V A N G
Sbjct: 16447 DGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAG 16502
Score = 73.9 bits (180), Expect = 5e-13
Identities = 117/490 (23%), Positives = 188/490 (38%), Gaps = 69/490 (14%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST-LTIYNANIDDAG 92
G S F CQV G+ K ++ +G LT R V +N + L I DDAG
Sbjct: 1096 GGSVVFGCQVGGNPKPH--VYWKKSGVPLTTGY-RYKVSYNKQTGECKLVISMTFADDAG 1152
Query: 93 IYKCVVTGEDGS---------ESEATVNVKIFQKLMFKNAPTP--QEFREGEDA----VI 137
Y VV + G E++ + +K Q+++++ T QE + GE A
Sbjct: 1153 EYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYS 1212
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKK----DVRFIVLSNNY-----LQIRGIKKTDEGTYR 188
+ +I K +D ++ + D F + S ++ R IK T E
Sbjct: 1213 EYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLE 1272
Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
+G E DI V +R I N G VT C G+P P ++W
Sbjct: 1273 EDGE-----EKMAVDISESEAVESGFDSR--IKNYRILEGMGVTFHCKMSGYPLPKIAWY 1325
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
KDG++I+ E + D + L I V DE Y A N G +A K++ +P
Sbjct: 1326 KDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG--NAICSGKLYVEP 1383
Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368
P+ + T+ + + S ++L V RS R+S
Sbjct: 1384 ------------------------AAPLGAPTYIPTLEPV-SRIRSLSPRSVSRSPIRMS 1418
Query: 369 SLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNI 424
+ + + A + A + G +++ LE Y P + PV+ EG
Sbjct: 1419 PARMSPARMSPA--RMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARF 1476
Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
+V P WF DGQ + ++Y++ + L + P + +D G + A NR
Sbjct: 1477 DLKVVGRPMPETFWFHDGQQI-VNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNR 1535
Query: 485 IGQESLEFIL 494
G+ S+ IL
Sbjct: 1536 AGRSSISVIL 1545
Score = 73.2 bits (178), Expect = 9e-13
Identities = 83/348 (23%), Positives = 134/348 (38%), Gaps = 21/348 (6%)
Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT 311
E+I + K + + +K + E+E+ I+E + D I F +
Sbjct: 30877 EEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEEL-- 30934
Query: 312 YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
+ + TL C+ +G P P + W + I ++ + + L
Sbjct: 30935 ---RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLK---YRIQEFKGGYHQLI 30988
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK------LQGPVAVYTWEGNQVNIT 425
+ S+ DA Y A+N G S + LEV+ K L+G AV+ G V+I
Sbjct: 30989 IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIK 31048
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
P I+W + L+ ++ + + I S + D G Y A NR
Sbjct: 31049 IPFSGKPDPVITWQKGQDLIDNNGHYQV-IVTRSFTSLVFPNGVERKDAGFYVVCAKNRF 31107
Query: 486 GQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEV 544
G + L AD P P +V S + + + EP + GG I Y E A E
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE- 31166
Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
+W +A E T++ L +T+Y R+ A N GL + S SE
Sbjct: 31167 ---RWLRVGQA-RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSE 31210
Score = 72.4 bits (176), Expect = 1e-12
Identities = 107/468 (22%), Positives = 171/468 (36%), Gaps = 66/468 (14%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAG-----EQDATIHLKVFA--KPKITYVENQTAMELEE 323
Q TI + + E E+ AEN+ G +I K+ + P I +L E
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548
Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
L+C+ G P+P I W + + K + S R +LT+ + + D G Y
Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRFGKELIQSRK-----YKMSSDGRTHTLTVMTEEQEDEGVY 30603
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAV----YTWEGNQVNITCEVFAYPSATISWF 439
C A+N +G+ S L +Q P+ + Y G+ + + P ++WF
Sbjct: 30604 TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF 30663
Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEV-TPDSENDFGNYNCTAVNRIGQ-ESLEFILVQ- 496
+LL N NI I NT ++L + + G Y N G +++ + +Q
Sbjct: 30664 HGQKLL--QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721
Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
D P+ P + + ++A + + P GG I Y E E ++W A
Sbjct: 30722 KPDKPTGPIVIEA-LLKNSAVISWKPPADDGGSWITNYVVEKCEAKE---GAEWQLVSSA 30777
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVHSPPPPASASSSTP 612
IV L Y R++A N G+ E+S+ K+ P P P + T
Sbjct: 30778 ISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKS-PFEKPGAPGK-PTITA 30835
Query: 613 VPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR-HYL 671
V W PA DGG+ IR +YL
Sbjct: 30836 VTKDSCVVAWKPPA----------------------------------SDGGAKIRNYYL 30861
Query: 672 VRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
+ ++W +K+L EYE V EN G+S+
Sbjct: 30862 EKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESE 30909
Score = 71.6 bits (174), Expect = 3e-12
Identities = 142/600 (23%), Positives = 241/600 (40%), Gaps = 71/600 (11%)
Query: 35 ESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIY 94
+S F C+V + + + W + NGE++ P R+S D LTI + D G Y
Sbjct: 12749 KSVTFWCKV--NRLNVTLKW-TKNGEEV-PFDNRVSYRV-DKYKHMLTIKDCGFPDEGEY 12803
Query: 95 KCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
V G+D S +E + I F Q E +DAV C + S + W
Sbjct: 12804 -IVTAGQDKSVAELLI---IEAPTEFVEHLEDQTVTEFDDAVFSCQL-SREKANVKWYRN 12858
Query: 155 GRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIVNVP 211
GR++ K +F + + L I+ + DE Y C E R +R + ++I V + P
Sbjct: 12859 GREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR-KSRARLFVEEIPVEIIRP 12917
Query: 212 PTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ 271
P Q+I+ A G V + + + + W ++ + Q D + + +
Sbjct: 12918 P-----QDILEAP---GADVVFLAELNK-DKVEVQWLRNNMVVVQG-DKHQMMSEGKIHR 12967
Query: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
L I + D+ EY IA++K +A L++ A PKI + +++ + +T+
Sbjct: 12968 LQICDIKPRDQGEYRFIAKDK----EARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPY 13023
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391
P W +S+ KT+D + A +S + + D G Y N
Sbjct: 13024 DAYPKAEAEWFKENEPLST--KTID------TTAEQTSFRILEAKKGDKGRYKIVLQNKH 13075
Query: 392 GQDSQSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCE--VFAYPSATISWFRDGQLL 445
G+ + L+V P GPV T++G +V++ E + S I + + + +
Sbjct: 13076 GKAEGFINLKVIDVP---GPVRNLEVTETFDG-EVSLAWEEPLTDGGSKIIGYVVERRDI 13131
Query: 446 PSSNYSNIKIYNTPSASYLEVTPDSENDFGN---YNCTAVNRIGQ-ESLEF-----ILVQ 496
+ + T A E T G + +A NR+G E +E +
Sbjct: 13132 KRKTW----VLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSK 13187
Query: 497 ADTPSSP---SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D P P +I V + + ++ PE GG I Y E R + +W A
Sbjct: 13188 YDVPGPPLNVTITDVNRFG--VSLTWEPPEYDGGAEITNYVIELR----DKTSIRWDTAM 13241
Query: 554 EASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KTQPVHSPPPPASASSS 610
E + T+ + Y+ R+ A N G+G+ SAA+ F P+ P PP + +SS
Sbjct: 13242 TVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSS 13301
Score = 71.6 bits (174), Expect = 3e-12
Identities = 79/340 (23%), Positives = 119/340 (35%), Gaps = 46/340 (13%)
Query: 406 PKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
P L+ P Y+ + G + I V P ISW +DG+ P + + + T +++ L
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE--PLKQTTRVNVEETATSTVL 24369
Query: 465 EVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 522
+ +++DFG Y TA N G E+L I+++ P + E + + ++ P
Sbjct: 24370 HIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPP 24429
Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582
TGG I Y E R WH + I LK T Y R+ A N
Sbjct: 24430 AYTGGCQISNYIVEKRDTTTTTWHM----VSATVARTTIKITKLKTGTEYQFRIFAENRY 24485
Query: 583 GLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKL 642
G K+ P+ S P P P T
Sbjct: 24486 G----------KSAPLDSKAVIVQYPFKEPGPPGTPFVT--------------------- 24514
Query: 643 EGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWN 702
+ +D ++ + D G I ++L + S W + P LD
Sbjct: 24515 --SISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEG 24572
Query: 703 AEYEVYVVAENQQGKSKAAH----FVFRTSAQPTAIPATL 738
EYE V AEN G K + FV R P P +
Sbjct: 24573 LEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAI 24612
Score = 71.2 bits (173), Expect = 3e-12
Identities = 76/308 (24%), Positives = 105/308 (34%), Gaps = 52/308 (16%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + VF P T+SW +DG LL + IK+ + LE+ + D G+Y
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPA--EGIKMAMQRNLCTLELFSVNRKDSGDYT 19367
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
TA N G +S L D P P S+ + YS A + ++ P GG I Y +
Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPET-----TYAVRLAALNGKGLGEISAASE 592
R W A + V I E Y R+ A N G+G+
Sbjct: 19428 RETSRPNW---------AQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 19478
Query: 593 FKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNS 652
+ + PP + + +W PA
Sbjct: 19479 AIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPA-------------------------- 19512
Query: 653 IKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 711
DDGGSPI YL+ R + W R P + L EYE V A
Sbjct: 19513 --------DDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTA 19564
Query: 712 ENQQGKSK 719
N+ G K
Sbjct: 19565 INKAGPGK 19572
Score = 70.9 bits (172), Expect = 4e-12
Identities = 85/380 (22%), Positives = 141/380 (37%), Gaps = 55/380 (14%)
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
W+TS +++ E T+ G + +KS+ A + ++ I ++ +
Sbjct: 26130 WKTSIQSLRGTEYTISGLTTGAEYV----FRVKSVNKVGASDPSDSSDPQIAKEREE--- 26182
Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460
E + + + G +T P + W + L + Y + T S
Sbjct: 26183 EPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAY----VDTTDS 26238
Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQF 519
+ L + + ND G Y T N + SL ++ DTP P+ V+ + +A + +
Sbjct: 26239 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 26298
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
D PE GG P+ Y E R ++ W S + S + + L+ Y R++
Sbjct: 26299 DVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK----VTNLQEGAIYYFRVSGE 26354
Query: 580 NGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSA 639
N G+G I A ++ + P PP T + TW P
Sbjct: 26355 NEFGVG-IPAETKEGVKITEKPSPPEKL-GVTSISKDSVSLTWLKP-------------- 26398
Query: 640 PKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP-SGSDHVMLKS 698
+ DGGS I HY+V AL K ++ + S H ++
Sbjct: 26399 --------------------EHDGGSRIVHYVV--EALEKGQKNWVKCAVAKSTHHVVSG 26436
Query: 699 LDWNAEYEVYVVAENQQGKS 718
L N+EY V AENQ G S
Sbjct: 26437 LRENSEYFFRVFAENQAGLS 26456
Score = 70.5 bits (171), Expect = 6e-12
Identities = 91/390 (23%), Positives = 142/390 (36%), Gaps = 62/390 (15%)
Query: 365 ARVSSLTLKSIQYTDAGEYI--CTASNTIGQ-DSQSMYL-----EVQYAPKLQGPVAVYT 416
ARV SL T EY+ A N G+ D +S+ + ++ P ++ + Y+
Sbjct: 23181 ARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYS 23240
Query: 417 WE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 475
+ G + I + P TI+W +DG LP + I + ++ + L + ++D G
Sbjct: 23241 VQVGQDLKIEVPISGRPKPTITWTKDG--LPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298
Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPIL 531
Y T N +GQ++ +V D P P D V S T + ++ P TGG I
Sbjct: 23299 QYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT--LSWNPPLYTGGCQIT 23356
Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y + R VW D A++ + + LK T Y R+ A N G +
Sbjct: 23357 NYIVQKRDTTTTVW-----DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALES 23411
Query: 591 SEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDG 650
Q + P P +T + W P
Sbjct: 23412 DPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPV------------------------ 23447
Query: 651 NSIKVNLIKQDDGGSP-IRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYV 709
++GGSP I ++L R S W + ++L+ EYE V
Sbjct: 23448 ----------NNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRV 23497
Query: 710 VAENQQGKSKAAH----FVFRTSAQPTAIP 735
AEN G KA+ +V R P P
Sbjct: 23498 YAENIVGVGKASKNSECYVARDPCDPPGTP 23527
Score = 69.7 bits (169), Expect = 1e-11
Identities = 79/325 (24%), Positives = 129/325 (39%), Gaps = 51/325 (15%)
Query: 401 EVQYAPKLQGPVAVYTW----EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456
++ AP++ VA+ T G V + P T++W +D + L S + I
Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSD--ARYSIE 27321
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA-DTPSSPSIDQVEPYS-ST 514
NT S+S L + + ND G Y T N +G+ + V+ DTP++ QV+ S T
Sbjct: 27322 NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGT 27381
Query: 515 AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAV 574
+ +D P GG PI+ Y E R + W + S + ++ L +T +
Sbjct: 27382 VTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFK----LIDLSEKTPFFF 27437
Query: 575 RLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPV-PLSPPDTTWPLPALATTEPA 633
R+ A N G+GE P + P +A P+ LS D+T L+ T+P
Sbjct: 27438 RVLAENEIGIGE----------PCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKP- 27486
Query: 634 KGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDH 693
DGGS I Y+V + + + S +
Sbjct: 27487 --------------------------DFDGGSVITEYVVERKGKGEQTWSHAGI-SKTCE 27519
Query: 694 VMLKSLDWNAEYEVYVVAENQQGKS 718
+ + L + E V A+N++G S
Sbjct: 27520 IEVSQLKEQSVLEFRVFAKNEKGLS 27544
Score = 69.3 bits (168), Expect = 1e-11
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD--KNDEAEY 285
GQ+ + + + P + W +G ++++ K +++ S LT++ +D +D Y
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNTSGVLTLEILDCHTDDSGTY 32444
Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
+ N GE L V TY + E+ V P +T RT
Sbjct: 32445 RAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSV----------FPELT-RTEA 32493
Query: 346 RNISSEEKTLDGHMV-----VRSHARVSSLTLKSIQYTDAGEYICTA--SNTIGQDSQSM 398
+SS +KT + V+S + +L S +++ + E A ++ + S +
Sbjct: 32494 YAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTR 32553
Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 457
++ A + L P ++ +EG +C+ P T++W R GQ+L +S + ++
Sbjct: 32554 KIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS--ARHQVTT 32611
Query: 458 TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-------VQADTPSSPSIDQVEP 510
T S E++ +D GNY+ N G++ EF L + S P + EP
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 32671
Score = 68.2 bits (165), Expect = 3e-11
Identities = 149/672 (22%), Positives = 245/672 (36%), Gaps = 104/672 (15%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE C V G + I W G ++ P+ R S + ++ L + + D
Sbjct: 8357 VSEGEYVQLSCHVQGSEPIR-IQWLKA-GREIKPSD-RCSFSFAS-GTAVLELRDVAKAD 8412
Query: 91 AGIYKCV---VTGEDGSESEATVNVK-----------IFQKLMFKNAPTPQEFREGEDAV 136
+G Y C V G D ++S+ T+ K + +L F + P E A
Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN---YLQIRGIKKTDEGTYRCEGRI 193
+ V P + W KG+ L + R + L+IR KTD G YRC
Sbjct: 8473 FIAKVGGDPIPNVKWT-KGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVA-F 8530
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT---MSWTKD 250
GEI VN+ + +Q + T + E M K+
Sbjct: 8531 NEHGEIESN-----VNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKN 8585
Query: 251 GEQIEQEEDDEKYIFSDDSSQLT---IKKVDKNDEAEYICIAENKAGEQD--------AT 299
+ E E+ Y +D L + K + +E + I E + E+D +
Sbjct: 8586 VDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSF 8645
Query: 300 IHLKVFAKPKITYV---ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--- 353
I ++ +T + ENQT ++ + V P ++W T + +K
Sbjct: 8646 IQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEI 8705
Query: 354 TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA 413
++DG +L +K+ Q D G Y I ++ +E + LQ
Sbjct: 8706 SIDGDR--------HTLRVKNCQLKDQGNYRLVCGPHIASAKLTV-IEPAWERHLQD--- 8753
Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
V EG +TC+ F+ P+ WFR+G++L ++ + L + D
Sbjct: 8754 VTLKEGQTCTMTCQ-FSVPNVKSEWFRNGRILKPQGRHKTEVEH--KVHKLTIADVRAED 8810
Query: 474 FGNYNC-------TAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST--AQVQFDEPEA 524
G Y C +A RI E ++F T +I E S+T +V FD+
Sbjct: 8811 QGQYTCKYEDLETSAELRIEAEPIQF------TKRIQNIVVSEHQSATFECEVSFDDAIV 8864
Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP--ETTYAVRLAALNGK 582
T W E+ S+ Y+ + +TI + P E Y+V +A L +
Sbjct: 8865 T-----------WYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSV-IARLEPR 8912
Query: 583 GLGEISAASEFKTQPVH-SPPPPASASSSTPVPLS----------PPDTTWPLPALATTE 631
G +A T+ + PP S P+P PP P+P L T
Sbjct: 8913 GEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPT- 8971
Query: 632 PAKGEPSAPKLE 643
P + +P ++E
Sbjct: 8972 PEEKKPPPKRIE 8983
Score = 68.2 bits (165), Expect = 3e-11
Identities = 78/321 (24%), Positives = 116/321 (36%), Gaps = 55/321 (17%)
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
EG +++I A P T+SW +DG+ + +S+ +K N +++LEV D G Y
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMK--NDHISAHLEVPKSVRADAGIY 14457
Query: 478 NCTAVNRIGQESLEFILVQADTPSS-PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
T N++G + + P I + S+ ++ ++ PE GG PIL Y E
Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE--FK 594
R G + + S T+ L P Y R+ A+N G GE
Sbjct: 14518 RREAGRRTYIPVMSGENKLSW----TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIA 14573
Query: 595 TQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIK 654
P P PP P TW P
Sbjct: 14574 QDPKQPPDPPVDVEVHNPT-AEAMTITWKPPLY--------------------------- 14605
Query: 655 VNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM------LKSLDWNAEYEVY 708
DGGS I Y++ A K E R ++H++ K L+ EY+
Sbjct: 14606 -------DGGSKIMGYIIEKIA-----KGEERWKRCNEHLVPILTYTAKGLEEGKEYQFR 14653
Query: 709 VVAENQQGKSKAAHFVFRTSA 729
V AEN G S+ + T A
Sbjct: 14654 VRAENAAGISEPSRATPPTKA 14674
Score = 68.2 bits (165), Expect = 3e-11
Identities = 127/608 (20%), Positives = 209/608 (34%), Gaps = 86/608 (14%)
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I+ V PPT+ W R + + + +S++ + I+ +++ +G Y +LA+
Sbjct: 16544 IIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMV-IKNCQRSHQGVYS----LLAK 16598
Query: 197 GEINFKDIQVIVNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
E + +IV+V P + + N +T + P ++ I
Sbjct: 16599 NEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYV-----I 16653
Query: 255 EQEEDDEK----YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD--ATIHLKVFAKP 308
E+ E D + ++ T++ + + + AEN G T V +P
Sbjct: 16654 EKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREP 16713
Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG---HMVVRSHA 365
IT E +E++E T + +P P + N E + + H V +
Sbjct: 16714 -ITVPERPEDLEVKEVTKNTVTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNL 16771
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE-VQYAPKLQGPVAVYTWEGNQVNI 424
T+K ++ D EY +A N +GQ S + + +L P +
Sbjct: 16772 LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIR 16831
Query: 425 TCEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
E FA P +SWF+D + + ++IK TP+ LE +D G Y
Sbjct: 16832 VGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIK--TTPATLALEKIKAKRSDSGKY 16889
Query: 478 NCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPILKY 533
N G + D P P S D+V + + P GG I Y
Sbjct: 16890 CVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVT--KDYMVISWKPPLDDGGSKITNY 16947
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
E + VG++V W AS + + L Y R+ A N G+ + +
Sbjct: 16948 IIEKKEVGKDV----WMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSM 17003
Query: 594 KTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSI 653
K + P T V TW P
Sbjct: 17004 KAKDRFRVPDAPDQPIVTEVTKDSALVTWNKP---------------------------- 17035
Query: 654 KVNLIKQDDGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLK----SLDWNAEYEVY 708
DGG PI +Y++ R +S W R+ H K L +YE
Sbjct: 17036 -------HDGGKPITNYILEKRETMSKRW---ARVTKDPIHPYTKFRVPDLLEGCQYEFR 17085
Query: 709 VVAENQQG 716
V AEN+ G
Sbjct: 17086 VSAENEIG 17093
Score = 68.2 bits (165), Expect = 3e-11
Identities = 85/364 (23%), Positives = 125/364 (34%), Gaps = 47/364 (12%)
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419
VVR+ T + + AG S + Q+M E+ Q V G
Sbjct: 21023 VVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--G 21080
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
+ + + V P T++W + Q+L + N + T +++ L + +D G Y
Sbjct: 21081 DNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE--TTATSTILNINECVRSDSGPYPL 21138
Query: 480 TAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
TA N +G+ + D P P+ I E S +D PE GGVPI Y E
Sbjct: 21139 TARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 21198
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596
R W + + GL+ Y R+ A N G+G I++A
Sbjct: 21199 RQTDSTTWVELATTVIRTTYKATRLTTGLE----YQFRVKAQNRYGVGPGITSACIVANY 21254
Query: 597 PVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
P P PP + T V +W P
Sbjct: 21255 PFKVPGPPGT-PQVTAVTKDSMTISWHEPL------------------------------ 21283
Query: 657 LIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 715
DGGSPI Y V + + W+ + + L YE V+AEN
Sbjct: 21284 ----SDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMA 21339
Query: 716 GKSK 719
GKSK
Sbjct: 21340 GKSK 21343
Score = 67.8 bits (164), Expect = 4e-11
Identities = 68/305 (22%), Positives = 106/305 (34%), Gaps = 46/305 (15%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + P T W DG + + + ++ N +S L + D G Y
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNF--SSVLTIKNCLRRDTGEYQ 17582
Query: 479 CTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
T N G +++ L D P P+ I V P T + + P+ GG P++ Y
Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT--ISWQPPKDDGGSPVINYI 17640
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E + ++ W S + + I L+ Y R+ A N G+G ++
Sbjct: 17641 VEKQDTRKDTWGV----VSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTV 17696
Query: 595 TQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIK 654
+ SPP P T + + +W LP
Sbjct: 17697 AKHKFSPPSPPGKPVVTDITENAATVSWTLP----------------------------- 17727
Query: 655 VNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQ 714
+ DGGSPI Y + R ++ +W + P + L YE V AEN
Sbjct: 17728 -----KSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENL 17782
Query: 715 QGKSK 719
G SK
Sbjct: 17783 AGLSK 17787
Score = 67.4 bits (163), Expect = 5e-11
Identities = 86/413 (20%), Positives = 160/413 (38%), Gaps = 35/413 (8%)
Query: 95 KCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
K +V E S+A+ V+ ++ K T EG+ V+ ++ + + W
Sbjct: 33018 KSIVHEEITKTSQASEEVRTHAEI--KAFSTQMSINEGQRLVLKANIAGATD--VKWVLN 33073
Query: 155 GRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRC-----EGRILARGEINFK----DI 204
G ++ ++ R+ V S+ L I+ DEG C EG + + ++ D
Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
++ P + QNI N GQ+V C+ G P P + W K+ I +
Sbjct: 33134 PAFISQPRS----QNI-----NEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSIS 33183
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
S + L I+ +D +Y A+N G+ AT L V P + + +
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL--PLVEEPSREVVLRTSGD 33241
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT----DA 380
+L S + ++ + SS + M A +S+ ++ S+Q + +
Sbjct: 33242 TSLQGSFSSQSV-QMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSS 33300
Query: 381 GEYICTASNTIGQDSQSMYLEVQYA---PKLQG-PVAVYTWEGNQVNITCEVFAYPSATI 436
++ ++ T + S S L+ PK++ P + EG + + C P+ +
Sbjct: 33301 SSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEV 33360
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
+W G+ + S I NT + L + + D G Y + N G +S
Sbjct: 33361 TWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 33413
Score = 67.0 bits (162), Expect = 6e-11
Identities = 134/583 (22%), Positives = 216/583 (37%), Gaps = 105/583 (18%)
Query: 190 EGRILARGEINFKDI-QVIVNVPPTIQARQNI--VNATANLGQSVTLVCDAEGFPEPTMS 246
+ +LA E F+ + V V PTI+ + I +N G+ L +G +
Sbjct: 18061 KANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLK 18120
Query: 247 WTK---DG----------EQIEQEEDDEK-YIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
W + DG +++ +D E+ + S + + + +N E+ +N+
Sbjct: 18121 WRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 18180
Query: 293 AGEQDATIHLKVFAKPKITY------VENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346
GE D +V K + + ++ + + L G P P + W T+
Sbjct: 18181 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAW---TK 18237
Query: 347 NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP 406
+ + + T + + + A S +L + +D G+Y+ TA+NT G S Y V
Sbjct: 18238 DKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG--SFVAYATVNVLD 18295
Query: 407 KLQGPV------------AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
K GPV W+ + + CE+ Y I + + + S YS
Sbjct: 18296 K-PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNY----ILEKCETKRMVWSTYSATV 18350
Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFIL-VQADTPSSPSIDQVE 509
+ TP + + +E F A N+IG ES I + D P P +V
Sbjct: 18351 L--TPGTTVTRLIEGNEYIF---RVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT 18405
Query: 510 PYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA-KEASMEGIVTIVGLK 567
S V ++ PE GG I Y E +E ++W K A E + + L
Sbjct: 18406 KVSKEEMTVVWNPPEYDGGKSITGYFLE----KKEKHSTRWVPVNKSAIPERRMKVQNLL 18461
Query: 568 PETTYAVRLAALNGKGLGEISAASE--FKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
P+ Y R+ A N G+GE S S P+ P PP + DTT
Sbjct: 18462 PDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTN--------FRVVDTTKHSI 18513
Query: 626 ALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPE- 684
L +P DGG+PI Y+V R ++ P+
Sbjct: 18514 TLGWGKPVY---------------------------DGGAPIIGYVVEMRPKIADASPDE 18546
Query: 685 --IRLPSGSDHV----MLKSLDWNAEYEVYVVAENQQGKSKAA 721
R + + V + SLD N EYE V A+NQ G + A
Sbjct: 18547 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPA 18589
Score = 67.0 bits (162), Expect = 6e-11
Identities = 85/348 (24%), Positives = 126/348 (36%), Gaps = 57/348 (16%)
Query: 189 CEGRILARGEINFKDIQVI-VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
C G I ++ ++ ++V + + P I++A G V VC E + + T
Sbjct: 31545 CGGAIRSQKGVSVAKVKVASIEIGPV---SGQIMHAVGEEGGHVKYVCKIENYDQSTQVT 31601
Query: 248 TKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
G + Q E+ EKY + D + L +K + K D+ Y C N GE + + ++F
Sbjct: 31602 WYFG--VRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS--YAELF 31657
Query: 306 AK------------------------------PKITY-VENQTAMELEEQVTLTCEASGD 334
K P+ T + N+TA + E V +
Sbjct: 31658 VKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAY-VGENVRFGVTITVH 31716
Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
P P +TW S + I + D S + LT+ S+ D EY A N G+D
Sbjct: 31717 PEPHVTWYKSGQKIKPGDN--DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGED 31774
Query: 395 SQSMYLEVQYAPKLQGPVA----------VYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
S L V P EG V V P T+ W +DGQ
Sbjct: 31775 SCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQ- 31833
Query: 445 LPSSNYSNIKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIGQESLE 491
P S NI+I + Y L + D G Y TA N G S +
Sbjct: 31834 -PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880
Score = 66.2 bits (160), Expect = 1e-10
Identities = 91/383 (23%), Positives = 151/383 (39%), Gaps = 46/383 (12%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G + L +G P P WTK+G+ I + S+ ++L IK+ D+ D Y
Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKR---AMIATSETHTELVIKEADRGDSGTYDL 30207
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
+ ENK G++ I ++V P + +E ++ + S P P+
Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPN----SPEGPLEYDDIQVRSVRVSWRP-PADDGGADILG 30262
Query: 348 ISSEEKTLD--GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405
E + + + S R +SL +K ++ + +A N G S+ + E
Sbjct: 30263 YILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFG-ISKPLKSEEPVT 30321
Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIKIYNTP-- 459
PK P + +++T S ++SW R DG + Y K +T
Sbjct: 30322 PKTPLNPPEPPSNPPEVLDVT-----KSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKW 30376
Query: 460 --------SASYLEVT---PDSENDFGNYNCTAVNRIG----QESLEFILVQ--ADTPSS 502
+ + VT PD+E F A N +G + E ++ + D PS
Sbjct: 30377 VRHNKTQITTTMYTVTGLVPDAEYQF---RIIAQNDVGLSETSPASEPVVCKDPFDKPSQ 30433
Query: 503 P-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561
P ++ + + +Q+++PE GG IL Y E+R G+ W KE +
Sbjct: 30434 PGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKK---SNKERIKDKQF 30490
Query: 562 TIVGLKPETTYAVRLAALNGKGL 584
TI GL T Y R+ A N GL
Sbjct: 30491 TIGGLLEATEYEFRVFAENETGL 30513
Score = 65.9 bits (159), Expect = 1e-10
Identities = 69/291 (23%), Positives = 100/291 (34%), Gaps = 42/291 (14%)
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
+ P SW + G+ + S+ + I +TP++S L + + D G Y TA N G
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDITQIT--STPTSSMLTIKYATRKDAGEYTITATNPFGT 20460
Query: 488 ESLEFILVQADTPSSPSIDQVEPYSS-TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546
+ + D P P ++ S+ A + + P GG PI Y E R +W
Sbjct: 20461 KVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPAS 606
D + I G Y R++A+N G GE + K PP P
Sbjct: 20521 VVSEDIQSCRHVATKLIQG----NEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPE 20576
Query: 607 ASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSP 666
+ V + +W P DDGGS
Sbjct: 20577 KPEVSNVTKNTATVSWKRPV----------------------------------DDGGSE 20602
Query: 667 IRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
I Y V R S W I+ P + L + YE V AEN+ G
Sbjct: 20603 ITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG 20653
Score = 65.5 bits (158), Expect = 2e-10
Identities = 130/641 (20%), Positives = 249/641 (38%), Gaps = 78/641 (12%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+V+ KD + WF +GE++ P+ + + D L I A++ D G Y C G
Sbjct: 11684 CEVS---KDVPVKWFK-DGEEIVPSPKYS--IKADGLRRILKIKKADLKDKGEYVCDC-G 11736
Query: 101 EDGSESEATVNVKIF--QKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
D +++ TV ++ +K ++ E E + DV WK KG+ +
Sbjct: 11737 TDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQ------WKLKGQPL 11790
Query: 159 ILKKDVRFIVLSNNYLQIRG---IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQ 215
D I ++ I + T E +++ A + K++ +I P
Sbjct: 11791 TASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA-ANLKVKELPLIFITP---- 11845
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ-LTI 274
+ + C+ P+ T W K ++I DD + D + + I
Sbjct: 11846 ----LSDVKVFEKDEAKFECEVSREPK-TFRWLKGTQEITG--DDRFELIKDGTKHSMVI 11898
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
K DEA+Y+ AE+K + ++ +T +++ TA E +E T E S D
Sbjct: 11899 KSAAFEDEAKYMFEAEDK--HTSGKLIIEGIRLKFLTPLKDVTAKE-KESAVFTVELSHD 11955
Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
I + W + + + + + ++ + S+T K + D + A +G
Sbjct: 11956 NI-RVKWFKNDQRLHTTRS-----VSMQDEGKTHSITFKDLSIDDTSQIRVEA---MGMS 12006
Query: 395 SQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
S++ ++ P G + YT E ++V + CE+ + A + WF+DG+ + S + I
Sbjct: 12007 SEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGKEIKPSKNAVI 12065
Query: 454 KIYNTPSASYLEVTPDSENDFGNYNC-----TAVNRIGQESLEFILVQADTPSSPSIDQV 508
K L+ ++D G Y C ++ E E LV+ S++ +
Sbjct: 12066 KADGKKRMLILKKA--LKSDIGQYTCDCGTDKTSGKLDIEDREIKLVR----PLHSVEVM 12119
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568
E ++ + + E + A W+ GE + + + KE + + +
Sbjct: 12120 ETETARFETEISEDD---------IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRL 12170
Query: 569 ETTYAVRLAALNGKGLGEISAASEF--KTQPVHSPPPPASASSSTPVPLSPPDTTWPLPA 626
+ T V A N K + +P+ A +++ LS D +P
Sbjct: 12171 DQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYED----IPV 12226
Query: 627 LATTEPAKGEPS---APKLEGQMGEDGNSIKVNLIKQDDGG 664
+ K EPS P+ EG++ +++ + +K +D G
Sbjct: 12227 EWYLKGKKLEPSDKVVPRSEGKV----HTLTLRDVKLEDAG 12263
Score = 65.5 bits (158), Expect = 2e-10
Identities = 163/779 (20%), Positives = 293/779 (37%), Gaps = 141/779 (18%)
Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
F CQ++ + + + W+ NG ++ ++ D S L I + +DD Y C
Sbjct: 12842 FSCQLSREKAN--VKWYR-NGREIKEGKKY--KFEKDGSIHRLIIKDCRLDDECEYAC-- 12894
Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
G + +S A + V +++ + PQ+ E A +V + + + V
Sbjct: 12895 -GVEDRKSRARLFV---EEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMV 12950
Query: 159 ILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRIL-ARGEINFKDIQVIVNVPPTIQ 215
+++ D ++ LQI IK D+G YR + AR ++ + P
Sbjct: 12951 VVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLE------LAAAPKIKT 13004
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
A Q++V ++G+ +T+V + +P+ W K+ E + + D + + + I
Sbjct: 13005 ADQDLV---VDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDT----TAEQTSFRIL 13057
Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKP------KITYV-ENQTAMELEEQVTLT 328
+ K D+ Y + +NK G+ + I+LKV P ++T + + ++ EE +T
Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPLT-- 13115
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
G I I + R+I + L V+ L ++Y + +A
Sbjct: 13116 --DGGSKI--IGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYL----FRVSAR 13167
Query: 389 NTIGQ----------DSQSMY------LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP 432
N +G +++S Y L V + V++ TWE + + E+ Y
Sbjct: 13168 NRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSL-TWEPPEYDGGAEITNY- 13225
Query: 433 SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488
+ RD + ++ + SA+ +V E F A NRIG
Sbjct: 13226 ---VIELRDKTSIRWDTAMTVRAEDL-SATVTDVVEGQEYSF---RVRAQNRIGVGKPSA 13278
Query: 489 SLEFILVQ--ADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545
+ F+ V + PS P ++ + S+ Q++++ P GG PIL Y E G++ W
Sbjct: 13279 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 13338
Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG-------LGEISAASEF--KTQ 596
+ E + GL+ Y R++A N G LG ++A F T
Sbjct: 13339 IR---CNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTM 13395
Query: 597 PVHSPPPPASASSSTPVPLSPPDTTWPLP---------ALATTEPAKGE----------- 636
+ + P+ + P T +P P L T + K +
Sbjct: 13396 DLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVIS 13455
Query: 637 PS--------APKLEGQMGEDGNSIKVNLIKQ-------------------------DDG 663
PS KLE ++ I VN+I + DDG
Sbjct: 13456 PSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDG 13515
Query: 664 GSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH 722
GSP+ Y+V R +S + ++ + L EY V A N+ G + A+
Sbjct: 13516 GSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAY 13574
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/293 (24%), Positives = 122/293 (41%), Gaps = 44/293 (15%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ + SG P P++TW + E+TL + + A SS+ +K+ Q + G Y
Sbjct: 16542 IRIIAYVSGKPPPTVTWNMN-------ERTLPQEATIETTAISSSMVIKNCQRSHQGVYS 16594
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDG 442
A N G+ +++ ++V P GPV N N +C+ ++WF D
Sbjct: 16595 LLAKNEAGERKKTIIVDVLDVP---GPVGTPFLAHNLTNESCK--------LTWFSPEDD 16643
Query: 443 QLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----E 488
P +NY K + T + V + + A N IG E
Sbjct: 16644 GGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVE 16703
Query: 489 SLEFILVQAD--TPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545
+ E ++++ P P ++ E +T + ++ P+ GG I+ Y E R +G E +
Sbjct: 16704 TSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKF 16763
Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598
H D + T+ GLK TY R++A+N G G+ S F T+P+
Sbjct: 16764 HKVTNDNL---LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS----FCTKPI 16809
Score = 65.5 bits (158), Expect = 2e-10
Identities = 99/405 (24%), Positives = 150/405 (37%), Gaps = 49/405 (12%)
Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
VPP+++ ++ G +V G P PT WT DG +I+ DE Y D
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKT---DEHYTVETD 17562
Query: 269 --SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT 326
SS LTIK + D EY N AG + +HL V P E +T
Sbjct: 17563 NFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT 17622
Query: 327 LTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
++ + D P I + + ++ D VV S + + L + +Q +
Sbjct: 17623 ISWQPPKDDGGSPVINY-----IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFR 17677
Query: 385 CTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF- 439
A N IG DS + +++P V T +IT +AT+SW
Sbjct: 17678 VRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVT------DIT-----ENAATVSWTL 17726
Query: 440 --RDGQLLPSSNYSN--------IKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIG-- 486
DG + Y +++ TP A VT E + + A N G
Sbjct: 17727 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786
Query: 487 QESLEFILVQADTPSSPSIDQVEP-----YSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
+ S ++A P P + P TA + + +P + GG PIL Y E + G
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
W+ + E + + GL Y R+ A N G GE
Sbjct: 17847 TAQWNR--INKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889
Score = 65.5 bits (158), Expect = 2e-10
Identities = 120/535 (22%), Positives = 195/535 (36%), Gaps = 98/535 (18%)
Query: 235 CDAEGFPEP--------TMSWTK---DGEQIEQEEDDEKYIFSDD-----------SSQL 272
CD G PEP T+ WTK DG + EK D +Q
Sbjct: 23521 CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580
Query: 273 TIKKVDKNDEAEYICIAENKAGE-------------QDATIHLKVFAKPKITYVENQTAM 319
T+ + ++ E+ IA+N AG +D ++ PK + +
Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKF---RDTIVV 23637
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E L + G P+P+I W + I + +++ + L +K D
Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDKEIEESARC-----EIKNTDFKALLIVKDAIRID 23692
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
G+YI ASN G S + ++V P +GPV V + ++T +
Sbjct: 23693 GGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDIS 23752
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQA 497
+ +S + + + + L+VT E + + AVN+ G E LE V
Sbjct: 23753 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 23812
Query: 498 DTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552
P S++ + V ++ P++ GG I+ Y E R + +W
Sbjct: 23813 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKR----DRSGIRWIKC 23868
Query: 553 KEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KTQPVHSPPPPASASS 609
+ + + + + GL + Y R++A N G+GE S A+ + PV P PP +A
Sbjct: 23869 NKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHI 23928
Query: 610 STPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH 669
DTT LA +P DGGS I
Sbjct: 23929 --------VDTTKNSITLAWGKPIY---------------------------DGGSEILG 23953
Query: 670 YLVRY-RALSSEWKPEIRLPSGSDHVM---LKSLDWNAEYEVYVVAENQQGKSKA 720
Y+V +A EW +I P V + L + EY++ V A N+ G +A
Sbjct: 23954 YVVEICKADEEEW--QIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEA 24006
Score = 65.1 bits (157), Expect = 2e-10
Identities = 101/431 (23%), Positives = 167/431 (38%), Gaps = 60/431 (13%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E+S ++ +C+V+ + + W+ + E + + I + L I NA+++
Sbjct: 12473 EVSETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILT---EGRKRILVIQNAHLE 12527
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
DAG Y C + S VK+ + F + P E EGE A VC + P
Sbjct: 12528 DAGNYNCRLPS-----SRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP- 12581
Query: 149 IIWKHKGR--------DVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ WK + DVI R +V+ + LQ G G R +
Sbjct: 12582 VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV----- 12636
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDA--EGFPEPTMSWTKDGEQIEQEE 258
+ ++++V + T Q Q V C+ EG W ++ E I
Sbjct: 12637 IEKLRIVVPLKDTRVKEQ----------QEVVFNCEVNTEG---AKAKWFRNEEAIF--- 12680
Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
D KYI D L I+ +D+A Y N GE + + + + VE
Sbjct: 12681 DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPL 12740
Query: 317 TAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+E E+ VT C+ + + ++ W T+N EE D + R LT+K
Sbjct: 12741 KDIETMEKKSVTFWCKVNRLNV-TLKW---TKN--GEEVPFDNRVSYRVDKYKHMLTIKD 12794
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFAYP 432
+ D GEYI TA GQD L + AP ++ E + +C++ +
Sbjct: 12795 CGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQL-SRE 12849
Query: 433 SATISWFRDGQ 443
A + W+R+G+
Sbjct: 12850 KANVKWYRNGR 12860
Score = 65.1 bits (157), Expect = 2e-10
Identities = 93/359 (25%), Positives = 137/359 (38%), Gaps = 73/359 (20%)
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P+P+ W T I ++E H V + S LT+K+ D GEY T SN G
Sbjct: 17536 GVPVPTAKWTTDGSEIKTDE-----HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAG 17590
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDGQLLPSSNY 450
+ +++L V P GP T N +++T E TISW +D P NY
Sbjct: 17591 SKTVAVHLTVLDVP---GPP---TGPINILDVTPE-----HMTISWQPPKDDGGSPVINY 17639
Query: 451 SNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ 496
K + + S + L++ + + A N+IG +S +
Sbjct: 17640 IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKH 17699
Query: 497 ADTPSSPSIDQV--EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
+P SP V + + A V + P++ GG PI Y E R V KW +
Sbjct: 17700 KFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREV-----TGKWVRVNK 17754
Query: 555 ASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPV 613
+ + + GL TY R+ A N GL S P P+S
Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFRVFAENLAGL---------------SKPSPSSDPIKACR 17799
Query: 614 PLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV 672
P+ PP G P PKL+ + E + + + DGGSPI Y+V
Sbjct: 17800 PIKPP----------------GPPINPKLKDKSRETADLVWTKPL--SDGGSPILGYVV 17840
Score = 65.1 bits (157), Expect = 2e-10
Identities = 77/291 (26%), Positives = 106/291 (36%), Gaps = 50/291 (17%)
Query: 432 PSATISWFRDGQLLPSSNYS-NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
P+ T W + P SN S I+ T S S L V + ND G Y T N G +S+
Sbjct: 28385 PTPTAVWSK-----PDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSI 28439
Query: 491 EFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549
F + DTP P I + +A + +D P GG I Y E R E W
Sbjct: 28440 TFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKR----EASRRSW 28495
Query: 550 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP-PASAS 608
E I + L Y R++A+N G+GE P P P A+
Sbjct: 28496 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGE----------PYEMPEPIVATEQ 28545
Query: 609 SSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR 668
+ P L DT+ LA +P DGGS I
Sbjct: 28546 PAPPRRLDVVDTSKSSAVLAWLKP---------------------------DHDGGSRIT 28578
Query: 669 HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
YL+ R S++ E + + ++ EYE V A+N G S+
Sbjct: 28579 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVE-KTEYEFRVKAKNDAGYSE 28628
Score = 64.7 bits (156), Expect = 3e-10
Identities = 74/331 (22%), Positives = 120/331 (36%), Gaps = 58/331 (17%)
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPT+ + + N T G+SVTL C G+P PT++W ++ QIE D + F +
Sbjct: 942 PPTLVS--GLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIA 998
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
+L I++ D + C A N+AG + +L V Q + E E++ T
Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV-----------QVSEEFEKETTAV-- 1045
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
T ++EEK +R +T S+ AG
Sbjct: 1046 --------------TEKFTTEEKRF-------VESRDVVMTDTSLTEEQAGP-------- 1076
Query: 391 IGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450
G+ + ++ KL EG V C+V P + W + G L +
Sbjct: 1077 -GEPAAPYFITKPVVQKLV--------EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYR 1127
Query: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE-FILVQADTPSSPSIDQVE 509
+ L ++ +D G Y N+ G+ S +L +AD Q
Sbjct: 1128 YKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEM 1187
Query: 510 PYSSTAQVQFDEP---EATGGVPILKYKAEW 537
Y + EP E G +Y+ E+
Sbjct: 1188 LYQTQVTAFVQEPKVGETAPGFVYSEYEKEY 1218
Score = 63.9 bits (154), Expect = 5e-10
Identities = 62/313 (19%), Positives = 122/313 (38%), Gaps = 47/313 (15%)
Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
++ +G + +T + P W ++GQ + I + + + L + D
Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISK----RAMIATSETHTELVIKEADRGD 30201
Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPIL 531
G Y+ N+ G++++ + +P+SP ++ + + +V + P GG IL
Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261
Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591
Y E R V + W++ + S+ + GLK Y R++A N G+ + +
Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGTSL----VVKGLKENVEYHFRVSAENQFGISKPLKSE 30317
Query: 592 EFKTQ--PVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGED 649
E T P++ P PP++ V S +W P
Sbjct: 30318 EPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRP------------------------ 30353
Query: 650 GNSIKVNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVY 708
+DDGGS + Y + + S++ W + + + L +AEY+
Sbjct: 30354 ----------KDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFR 30403
Query: 709 VVAENQQGKSKAA 721
++A+N G S+ +
Sbjct: 30404 IIAQNDVGLSETS 30416
Score = 63.5 bits (153), Expect = 7e-10
Identities = 96/424 (22%), Positives = 155/424 (36%), Gaps = 81/424 (19%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E L + G PIP + W + + E+T M ++S + ++L +K TD G+
Sbjct: 24723 ETFVLEADIRGKPIPDVVWSKDGKEL---EETA-ARMEIKSTIQKTTLVVKDCIRTDGGQ 24778
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAV---------YTW----EGNQVNITCEV 428
YI SN G S + ++V P +GP+ V W + NI+ +
Sbjct: 24779 YILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYI 24838
Query: 429 F-AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG- 486
++ +SW + + + NY K+ P Y+ + AVN+ G
Sbjct: 24839 IEKRETSRLSWTQVSTEVQALNYKVTKL--LPGNEYI------------FRVMAVNKYGI 24884
Query: 487 QESLEFILVQA----DTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVG 541
E LE V A P PS +V + + V + P GG I Y E R
Sbjct: 24885 GEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKR--- 24941
Query: 542 EEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF-KTQPVH 599
+ +W + ++ + + + GL +Y R+AA N G+GE S S F +
Sbjct: 24942 -DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDAL 25000
Query: 600 SPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIK 659
PP P S T S W P
Sbjct: 25001 YPPGPPSNPKVTDTSRSSVSLAWSKPIY-------------------------------- 25028
Query: 660 QDDGGSPIRHYLVRYRALSSEWKPEIRLPSG--SDHVMLKSLDWNAEYEVYVVAENQQGK 717
DGG+P++ Y+V + +++ P+G + L N EY + A N +G
Sbjct: 25029 --DGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGV 25086
Query: 718 SKAA 721
+ A
Sbjct: 25087 GEPA 25090
Score = 62.0 bits (149), Expect = 2e-09
Identities = 97/415 (23%), Positives = 163/415 (39%), Gaps = 66/415 (15%)
Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
+ P + GE+ F C+V G + K ++W+ NG+ L +R V + D L I
Sbjct: 1845 LYPEPVRVLEGETARFRCRVTGYPQPK-VNWYL-NGQ-LIRKSKRFRVRY--DGIHYLDI 1899
Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKN----APTPQ-EFREGEDAVIV 138
+ D G K +G E V ++I Q+ F++ AP P+ EF E +
Sbjct: 1900 VDCKSYDTGEVKVTAENPEGV-IEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQ 1958
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNYLQIRGIKKTDEGTYRC----- 189
+V P + K V LK+ R + + L+ + ++T+EG Y
Sbjct: 1959 FEVQKVDRPVDTTETK-EVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVE 2017
Query: 190 -------------------------------EGRILAR-GEINFKDIQVI-VNVPPTIQA 216
E + LA G+I + + + P+++A
Sbjct: 2018 LKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEA 2077
Query: 217 R---QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
+ I + T G G P+P W K+G +IE+ + Y D+ +L
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV 2137
Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY---VENQTAMELEEQVTLTCE 330
I+ V D A + A N AGE + L V AK IT+ +++ A E + T CE
Sbjct: 2138 IRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECE 2197
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
S +P + W + +K + S +V L++ +I +DA +Y C
Sbjct: 2198 TS-EPFVKVKWYKDGMEVHEGDK-----YRMHSDRKVHFLSILTIDTSDAEDYSC 2246
Score = 61.6 bits (148), Expect = 3e-09
Identities = 101/468 (21%), Positives = 183/468 (39%), Gaps = 64/468 (13%)
Query: 168 VLSNNYLQIRGIKKTDEGTYRCEG-RILARGEINFKDIQVIVN---VPPTIQA--RQNIV 221
+LS Y ++G+K+ D YR I+ +G+ +F + PPT+ R +
Sbjct: 16771 LLSRKYT-VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKL- 16828
Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK-KVDKN 280
T +G++ L G P+P +SW KD + + EDD +I + ++ K K ++
Sbjct: 16829 --TIRVGEAFALTGRYSGKPKPKVSWFKD--EADVLEDDRTHIKTTPATLALEKIKAKRS 16884
Query: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340
D +Y + EN G + + V +P ++ + ++ + P+
Sbjct: 16885 DSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKP---PLDDGG 16941
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT--ASNTIGQDSQSM 398
+ + I +E D M V S + + T K + + +YI A N G +
Sbjct: 16942 SKITNYIIEKKEVGKDVWMPVTSAS--AKTTCKVSKLLEGKDYIFRIHAENLYGISDPLV 16999
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--DGQLLPSSNYSNIKIY 456
++ + + P + I EV SA ++W + DG P +NY ++
Sbjct: 17000 SDSMKAKDRFRVP------DAPDQPIVTEV-TKDSALVTWNKPHDGGK-PITNYI-LEKR 17050
Query: 457 NTPSASYLEVTPDSENDFGNYN-------CTAVNRIGQESLEFILVQADTPSSPSI---- 505
T S + VT D + + + C R+ E+ E + PS P
Sbjct: 17051 ETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAEN-EIGIGDPSPPSKPVFAKDP 17109
Query: 506 ----------DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+ ++ ++ + + P GG IL Y E++ VG+E W + E+
Sbjct: 17110 IAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWR-RANHTPES 17168
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
E + GL+ TY R+ A+N G ++ P H P P
Sbjct: 17169 CPETKYKVTGLRDGQTYKFRVLAVNAAG----------ESDPAHVPEP 17206
Score = 61.2 bits (147), Expect = 3e-09
Identities = 50/180 (27%), Positives = 81/180 (45%), Gaps = 9/180 (5%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE-DDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
G + T GFP P +SW +DG+ I + FSD ++LTI V K + Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79
Query: 287 CIAENKAGEQDATIHLKVFAK-PKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRT 343
A N +G+ +T L V A+ +V+ +M + + QV L +G P P + +
Sbjct: 80 LKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYR 139
Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
I S +LD + + SL + D+G Y A+N++G+ + + L VQ
Sbjct: 140 DGAEIQS---SLD--FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 60.1 bits (144), Expect = 8e-09
Identities = 83/319 (26%), Positives = 119/319 (37%), Gaps = 49/319 (15%)
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465
PK + + V+ G + +++ P TI W + Q L SN + ++I +T A+ L
Sbjct: 22547 PKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQEL--SNTARLEIKSTDFATSLS 22602
Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDE 521
V D GNY A N G+ S+ + D P P I V T + +
Sbjct: 22603 VKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT--LAWKP 22660
Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNG 581
P GG I+ Y E R VW DA ++ VT L Y R+ A+N
Sbjct: 22661 PLQDGGSDIINYIVERRETSRLVW--TVVDANVQTLSCKVT--KLLEGNEYTFRIMAVNK 22716
Query: 582 KGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPK 641
G+GE P+ S P A P PD P AP+
Sbjct: 22717 YGVGE----------PLESEPVVAKN------PFVVPDA----------------PKAPE 22744
Query: 642 LEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLD 700
+ + + I V DGGS I Y++ R W + G + + L
Sbjct: 22745 VTTVTKD--SMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLI 22802
Query: 701 WNAEYEVYVVAENQQGKSK 719
N +YE V AEN G S+
Sbjct: 22803 ENHDYEFRVSAENAAGLSE 22821
Score = 60.1 bits (144), Expect = 8e-09
Identities = 83/356 (23%), Positives = 135/356 (37%), Gaps = 49/356 (13%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLT 328
++ I K+ ++ E + A NK G +AT + V + K+ E EL + + +
Sbjct: 23978 TRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVR 24037
Query: 329 CEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
S G P P ITW S EE + + + L++ + DA
Sbjct: 24038 AGGSARIHIPFKGRPTPEITW-------SREEGEFTDKVQIEKGVNYTQLSIDNCDRNDA 24090
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY 431
G+YI N+ G S + ++V P +++ A WE ++ +V Y
Sbjct: 24091 GKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNY 24150
Query: 432 PSATISWFRDGQLLPSSNYS--NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
R SS S + K+ N + +EN+FG +G
Sbjct: 24151 VIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFG---------VGVPV 24201
Query: 490 LEFILVQADTPSSP--SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
V+A P SP + + ++A + +++PE GG +L Y E + G E
Sbjct: 24202 ETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTE---- 24257
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG------LGEISAASEFKTQP 597
KW E+ + V + GL Y R+ A N KG LG A + QP
Sbjct: 24258 KWSIVAESKVCNAV-VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQP 24312
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/329 (23%), Positives = 120/329 (36%), Gaps = 58/329 (17%)
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNY-----SNIKIYNTPSASYLEVTPDSEN 472
EG VNI ++ P T++WF+ P + +++ L + +
Sbjct: 16130 EGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRS 16189
Query: 473 DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVP 529
D G Y TAVN +G S E L P P + ++ S +A + + P+ GG
Sbjct: 16190 DTGLYTITAVNNLGTASKEMRLNVLGRP-GPPVGPIKFESVSADQMTLSWFPPKDDGGSK 16248
Query: 530 ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 589
I Y E R + W + KE + TI L Y R+ A N G+GE
Sbjct: 16249 ITNYVIEKREANRKTWVHVSSEPKECT----YTIPKLLEGHEYVFRIMAQNKYGIGE--- 16301
Query: 590 ASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGED 649
P+ S P A S P G P P +
Sbjct: 16302 -------PLDSEPETARNLFSVP----------------------GAPDKPTVS---SVT 16329
Query: 650 GNSIKVNLIKQD-DGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEV 707
NS+ VN + + DGGSP+ Y + + S WK R P +K++ Y+V
Sbjct: 16330 RNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDP-------IKAMTLGVSYKV 16382
Query: 708 YVVAENQQGKSKAAHFVFRTSAQPTAIPA 736
+ E + + + + P ++P+
Sbjct: 16383 TGLIEGSDYQFR-VYAINAAGVGPASLPS 16410
Score = 59.3 bits (142), Expect = 1e-08
Identities = 79/317 (24%), Positives = 124/317 (39%), Gaps = 49/317 (15%)
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P+P +W + ++I + T + S S LT+K DAGEY TA+N G
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQ-----ITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSN 449
+ + + V P GPV + N++ E AT++W DG P +
Sbjct: 20460 TKVEHVKVTVLDVPGPPGPVEI-------SNVSAE-----KATLTWTPPLEDGG-SPIKS 20506
Query: 450 YSNIKIYNTPSASYLEVTPDSEN--------DFGN---YNCTAVNRIGQ------ESLEF 492
Y ++ T + V+ D ++ GN + +AVN G+ E ++
Sbjct: 20507 YI-LEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKM 20565
Query: 493 I--LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
+ P P + V +TA V + P GG I Y E R E +W
Sbjct: 20566 VDRFGPPGPPEKPEVSNVT--KNTATVSWKRPVDDGGSEITGYHVERR----EKKSLRWV 20619
Query: 551 DAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVHSPPPPASAS 608
A + + + + GL+ +TY R++A N G+G S AS+ + PP P S
Sbjct: 20620 RAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNP 20679
Query: 609 SSTPVPLSPPDTTWPLP 625
T W P
Sbjct: 20680 HVTDTTKKSASLAWGKP 20696
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/399 (21%), Positives = 157/399 (39%), Gaps = 34/399 (8%)
Query: 209 NVPPTIQARQNIVNATA-NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
NVPP ++ + G+S+ + +G P P ++W KDG +IE+ + E +D
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---ITD 28009
Query: 268 --DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
S+ L ++ ++ Y A+N +G A I +KV P + E++
Sbjct: 28010 VLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKM 28069
Query: 326 TLTCEAS-GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
TL +A D IT I E + ++ S T + + ++
Sbjct: 28070 TLWWDAPLNDGCAPITHYI----IEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFR 28125
Query: 385 CTASNTIG----QDSQSMYLEVQY-APKLQGPVAVYTWEGNQVNITCEVFAYP-----SA 434
+A N G DS + ++QY P G GN + +T +A P S
Sbjct: 28126 VSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLT---WARPESDGGSE 28182
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI- 493
+ + + S+ + + S + +VT +E + ++ A N G I
Sbjct: 28183 IQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGIS 28242
Query: 494 -LVQADTPSSPS-----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
L++ P +P + + +T +++ +P GG+ I+ Y E WH
Sbjct: 28243 RLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHK 28302
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
EA ++ T+ L+ Y R++A+NG G G+
Sbjct: 28303 V---NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGD 28338
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/345 (23%), Positives = 124/345 (35%), Gaps = 52/345 (15%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + I V P ++WF+DG + N++I + ++ L V + + G Y
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDG--VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
A N G E + DTP + + + T + + +D P G PI Y
Sbjct: 28031 VEAKNASGSAKAEIKVKVQDTPGKV-VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYII 28089
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
E R W + S I I G Y R++A+N G+G
Sbjct: 28090 EKRETSRLAWALIEDKCEAQSYTAIKLING----NEYQFRVSAVNKFGVG---------- 28135
Query: 596 QPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKV 655
+P+ S P A + P AP + GNSI +
Sbjct: 28136 RPLDSDPVVAQIQYTVP-------------------------DAPGIPEPSNITGNSITL 28170
Query: 656 NLIK-QDDGGSPIRHYLVRYRAL-SSEWKPEI-RLPSGSDHVMLKSLDWNAEYEVYVVAE 712
+ + DGGS I+ Y++ R S+ W I + P + L EYE +V+AE
Sbjct: 28171 TWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAE 28230
Query: 713 NQQGKSKAAH----FVFRTSAQPTAIPATLGGNSASYTFVSLLFS 753
N G A+ R P P + S T VSL +S
Sbjct: 28231 NAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWS 28275
Score = 58.9 bits (141), Expect = 2e-08
Identities = 121/511 (23%), Positives = 190/511 (37%), Gaps = 94/511 (18%)
Query: 273 TIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKITYVENQTAMELE--EQVTL 327
T K +++ E ++ AEN AG + AT K V +T++E++ +++ L
Sbjct: 14640 TAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIAL 14699
Query: 328 TCEASGDPIPSITWRTSTRNISSEE-KTLDGHMVVRSHARVSS-------LTLK-SIQYT 378
SG P P+ITW I EE K +V R V LT + SI +
Sbjct: 14700 DASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNS 14759
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQY---APKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
GE +++ D ++V+ K V+V G +N E S
Sbjct: 14760 KKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVL 14819
Query: 436 ISW---FRDG-------------QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
W DG + P S + I + +T VT E +
Sbjct: 14820 CKWEPPLDDGGSEIINYTLEKKDKTKPDSEW--IVVTSTLRHCKYSVTKLIEGKEYLFRV 14877
Query: 480 TAVNRIGQ--ESLEFILVQADT---PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKY 533
A NR G + LV D P +P VE +S + V+++EP+ G PIL Y
Sbjct: 14878 RAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGY 14936
Query: 534 KAEWRAVGEEVW---HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
E R V W + +A +A+++G++ GL TY R+ A N G G+ S
Sbjct: 14937 WLEKREVNSTHWSRVNKSLLNALKANVDGLLE--GL----TYVFRVCAENAAGPGKFSPP 14990
Query: 591 SEFKT--QPVHSPPPP---ASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQ 645
S+ KT P+ P PP + +SST + L W PA
Sbjct: 14991 SDPKTAHDPISPPGPPIPRVTDTSSTTIELE-----WEPPAF------------------ 15027
Query: 646 MGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEY 705
+ GG + +++ + ++EW +K + A+Y
Sbjct: 15028 ---------------NGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADY 15072
Query: 706 EVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 736
++ V A N G+ T A+P PA
Sbjct: 15073 KLRVSAVNAAGEGPPGETQPVTVAEPQEPPA 15103
Score = 58.9 bits (141), Expect = 2e-08
Identities = 95/422 (22%), Positives = 159/422 (37%), Gaps = 83/422 (19%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L +G P P+ +W + + E+ + V +H +V+ LT++ D GEY
Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESER-----VTVETHTKVAKLTIRETTIRDTGEYT 29810
Query: 385 CTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FR 440
N G S+++ + + P GP+ + ++++ T S TISW
Sbjct: 29811 LELKNVTGTTSETIKVIILDKPGPPTGPIKI-----DEIDAT-------SITISWEPPEL 29858
Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES- 489
DG P S Y + + + + S + T +E + + A NR G S
Sbjct: 29859 DGG-APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSY 29917
Query: 490 LEFILVQADT----PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEV 544
L+ +++ + P P Q+ S + + PE GG + Y E +EV
Sbjct: 29918 LQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE----RKEV 29973
Query: 545 WHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
+W + + GL Y R+ A+N +G G+ S P
Sbjct: 29974 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPS-----------RPSK 30022
Query: 604 PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL---IKQ 660
P A P++PP G+P P++ D V+L + +
Sbjct: 30023 PIVAMD----PIAPP----------------GKPQNPRV-----TDTTRTSVSLAWSVPE 30057
Query: 661 DDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
D+GGS + YL+ + + EW P+ L L AEY V+A N G +
Sbjct: 30058 DEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGE 30117
Query: 720 AA 721
A
Sbjct: 30118 PA 30119
Score = 58.5 bits (140), Expect = 2e-08
Identities = 70/334 (20%), Positives = 122/334 (36%), Gaps = 65/334 (19%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
GQ+ G P P W DG+QI + + I D + L I +D E+
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 288 IAENKAGEQDATIHLKVFA---KPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWR 342
+A+N+AG ++ L V A + K +VE + ++E ++ + A+G+P P I W
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ--SMYL 400
++ I + + + ++L + S D+ Y TA N G+D+ + +
Sbjct: 1591 KNSDIIVPHKYP---KIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Query: 401 EVQYAP-----KLQGPVAVY--------------------TWEGNQV------------- 422
EV++A KL P Y WE +
Sbjct: 1648 EVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKK 1707
Query: 423 -------------NITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
+ C + P+ + W DG+ L ++N +++ N L+
Sbjct: 1708 KLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAAN--RLRMINEFGYCSLDYG 1765
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
D G C A N+ G + L+ D S
Sbjct: 1766 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKS 1799
Score = 58.5 bits (140), Expect = 2e-08
Identities = 80/324 (24%), Positives = 121/324 (37%), Gaps = 58/324 (17%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
PKI E Q ++ +++ + G P P+ W+ +E H+ V
Sbjct: 18900 PKILMPE-QITIKAGKKLRIEAHVYGKPHPTCKWKKG-----EDEVVTSSHLAVHKADSS 18953
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTW 417
S L +K + D+G Y TA N+ G D+Q + + V AP + +W
Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 19013
Query: 418 ----EGNQVNIT------CE------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461
E NIT C+ V A S T + R G+L+P Y I+
Sbjct: 19014 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEY----IFRV--- 19066
Query: 462 SYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQF 519
+EN FG + T+ + Q PS P +V + V +
Sbjct: 19067 -------RAENRFGISEPLTSPKMVAQ-------FPFGVPSEPKNARVTKVNKDCIFVAW 19112
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
D P++ GG PI+ Y E + +W K D S E GL Y+ R+ AL
Sbjct: 19113 DRPDSDGGSPIIGYLIERKERNSLLW-VKANDTLVRSTE--YPCAGLVEGLEYSFRIYAL 19169
Query: 580 NGKGLGEISAASEFKTQPVHSPPP 603
N G S +E+ T + PP
Sbjct: 19170 NKAGSSPPSKPTEYVTARMPVDPP 19193
Score = 58.5 bits (140), Expect = 2e-08
Identities = 76/305 (24%), Positives = 124/305 (40%), Gaps = 45/305 (14%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E + + G PIP+I W + +S+ + + ++S +SL++K D+G
Sbjct: 22559 ESFKVDADIYGKPIPTIQWIKGDQELSNTAR-----LEIKSTDFATSLSVKDAVRVDSGN 22613
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW--- 438
YI A N G+ S ++ ++V P +GPV + +T E T++W
Sbjct: 22614 YILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI-------SGVTAE-----KCTLAWKPP 22661
Query: 439 FRDG-----QLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIG-QE 488
+DG + ++ ++ A+ +VT E + + AVN+ G E
Sbjct: 22662 LQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGE 22721
Query: 489 SLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
LE V A D P +P + V S V ++ P + GG IL Y E R
Sbjct: 22722 PLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI--VVWERPASDGGSEILGYVLEKRDKE 22779
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK--TQPVH 599
W K E + + GL Y R++A N GL E S S ++ P++
Sbjct: 22780 GIRWTR---CHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 22836
Query: 600 SPPPP 604
P PP
Sbjct: 22837 KPGPP 22841
Score = 58.2 bits (139), Expect = 3e-08
Identities = 108/530 (20%), Positives = 176/530 (33%), Gaps = 91/530 (17%)
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD- 278
+ T G + L G PEP ++WTK ++Q D++ + + T+ VD
Sbjct: 13697 LAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITIENVPKKSTVTIVDS 13753
Query: 279 -KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP 337
++D YI A N G A + + V KP A ++ + +C + +P P
Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDKP-----GPPAAFDITDVTNESCLLTWNP-P 13807
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNT--IGQ 393
+ N E + D + + + V K+ + EYI A N +G+
Sbjct: 13808 RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGE 13867
Query: 394 DSQSMYLEVQYAPKLQGP------------VAVYTW-----EGNQVNITCEVFAYPSATI 436
Q+ + +Y GP TW +G V T
Sbjct: 13868 PVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD 13927
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496
W R ++ +K V ++ G +S E IL++
Sbjct: 13928 KWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK---------PSKSTEPILIK 13978
Query: 497 --ADTPSSPSIDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D P P V+ T+ ++ + +PE GG I Y E G + W
Sbjct: 13979 DPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW-------- 14030
Query: 554 EASMEGIVT----IVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVHSPPPPASAS 608
EG+ T + GL Y+ R+ A+N G E S S+ + PP P
Sbjct: 14031 VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWL 14090
Query: 609 SSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR 668
+ + D W +P + DGGSPI
Sbjct: 14091 EVINITKNTADLKWTVP----------------------------------EKDGGSPIT 14116
Query: 669 HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 718
+Y+V R + + + + L + Y V AEN G+S
Sbjct: 14117 NYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS 14166
Score = 58.2 bits (139), Expect = 3e-08
Identities = 104/490 (21%), Positives = 180/490 (36%), Gaps = 88/490 (17%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---------KPKITYVENQTAM 319
++ ++ +D++ E+ A N+ GE + ++ L V K +++ + +
Sbjct: 15351 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKV 15410
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV-----RSHARVSSLTLKS 374
+ E V + + +G P+P I W ++N + EK D + RS A+ K+
Sbjct: 15411 KAGEPVHIPADVTGLPMPKIEW---SKNETVIEKPTDALQITKEEVSRSEAKTELSIPKA 15467
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNIT 425
++ D G Y TASN +G +++++EV P +AV TW+ N
Sbjct: 15468 VR-EDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGG 15526
Query: 426 CEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NY 477
E+ Y W Y K+ P+ Y E + N +G +
Sbjct: 15527 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKL--IPNGQY-EFRVRAVNKYGISD 15583
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
C + + Q+ P P + + + V + P GG PI Y E
Sbjct: 15584 ECKSDKVVIQDPYRL----PGPPGKPKV--LARTKGSMLVSWTPPLDNGGSPITGYWLEK 15637
Query: 538 RAVGEEVW-HSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS--EF 593
R G W + ++G+ + L Y R A+N G+G S S E
Sbjct: 15638 REEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEV 15697
Query: 594 KTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSI 653
P+ P PP+ D T +L PAK
Sbjct: 15698 AGDPIFPPGPPSCPEVK--------DKTKSSISLGWKPPAK------------------- 15730
Query: 654 KVNLIKQDDGGSPIRHYLVRYRAL-SSEWKPEIRLPS---GSDHVMLKSLDWNAEYEVYV 709
DGGSPI+ Y+V + +++WK + P + ++ +L +Y V
Sbjct: 15731 --------DGGSPIKGYIVEMQEEGTTDWK-RVNEPDKLITTCECVVPNLKELRKYRFRV 15781
Query: 710 VAENQQGKSK 719
A N+ G+S+
Sbjct: 15782 KAVNEAGESE 15791
Score = 57.8 bits (138), Expect = 4e-08
Identities = 87/402 (21%), Positives = 152/402 (37%), Gaps = 40/402 (9%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ + +D G Y V+ DG ++ + +K + + + Q+ EG+ ++ +
Sbjct: 2323 LTVKDVTKEDQGEYSFVI---DGKKTTCKLKMKP-RPIAILQGLSDQKVCEGD--IVQLE 2376
Query: 141 VVSSLPPTI-IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA--- 195
V SL +W G++V V ++ ++ L I + K D G Y L
Sbjct: 2377 VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLST 2436
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G ++ + VI + N++ T L C ++ W + EQI+
Sbjct: 2437 SGRVSVYSVDVITPLKDV-----NVIEGT-----KAVLECKVSVPDVTSVKWYLNDEQIK 2486
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ D + I +L I + +DE Y I G + +L V I + +
Sbjct: 2487 PD-DRVQAIVKGTKQRLVINRTHASDEGPYKLIV----GRVETNCNLSVEKIKIIRGLRD 2541
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
T E + V E S I + W + I K + +H ++ LT+ ++
Sbjct: 2542 LTCTETQN-VVFEVELSHSGI-DVLWNFKDKEIKPSSK-----YKIEAHGKIYKLTVLNM 2594
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
D G+Y A + ++ P VA E + CEV A P +
Sbjct: 2595 MKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVA----ESQEAVFECEV-ANPDSK 2649
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
W RDG+ LP +N NI+ + L + +D G Y
Sbjct: 2650 GEWLRDGKHLPLTN--NIRSESDGHKRRLIIAATKLDDIGEY 2689
Score = 57.8 bits (138), Expect = 4e-08
Identities = 98/463 (21%), Positives = 195/463 (42%), Gaps = 64/463 (13%)
Query: 35 ESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSS-TLTIYNANIDDAGI 93
ES F +++ D + + WF N ++L + SV D+ + ++T + +IDD
Sbjct: 11944 ESAVFTVELSHD--NIRVKWFK-NDQRLHTTR---SVSMQDEGKTHSITFKDLSIDDTSQ 11997
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
+ G SE++ TV + F E ++ ++ C++ + P + W
Sbjct: 11998 IRVEAMGMS-SEAKLTV---LEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFK 12052
Query: 154 KGRDV------ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-GRILARGEINFKDIQV 206
G+++ ++K D + L ++ K+D G Y C+ G G+++ +D ++
Sbjct: 12053 DGKEIKPSKNAVIKADGK-----KRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREI 12107
Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE-KYIF 265
+ P + + + + TA ++ + +W GE + Q D E K
Sbjct: 12108 KLVRP--LHSVEVMETETARFETEISE-------DDIHANWKLKGEALLQTPDCEIKEEG 12158
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QTAMELE 322
S L ++D+ ++ +A ++ HL+V KP++ + +
Sbjct: 12159 KIHSLVLHNCRLDQTGGVDF------QAANVKSSAHLRV--KPRVIGLLRPLKDVTVTAG 12210
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E T CE S + IP + W + + +K +V RS +V +LTL+ ++ DAGE
Sbjct: 12211 ETATFDCELSYEDIP-VEWYLKGKKLEPSDK-----VVPRSEGKVHTLTLRDVKLEDAGE 12264
Query: 383 YICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 439
TA + + +++++ V++ L+ EG + CEV + +A + WF
Sbjct: 12265 VQLTAKDF--KTHANLFVKEPPVEFTKPLEDQTVE---EGATAVLECEV-SRENAKVKWF 12318
Query: 440 RDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
++G ++L S Y + + TP+ D Y C A
Sbjct: 12319 KNGTEILKSKKYEIVADGRVRKLVIHDCTPE---DIKTYTCDA 12358
Score = 57.8 bits (138), Expect = 4e-08
Identities = 99/403 (24%), Positives = 159/403 (39%), Gaps = 62/403 (15%)
Query: 213 TIQARQNIV-NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ 271
TI+A IV NA + LG+ P P SW+K G+ I + D + + SS
Sbjct: 20389 TIKAGDTIVLNAISILGK-----------PLPKSSWSKAGKDI-RPSDITQITSTPTSSM 20436
Query: 272 LTIKKVDKNDEAEYICIAENKAG---EQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
LTIK + D EY A N G E L V P + N +A + T
Sbjct: 20437 LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP 20496
Query: 329 CEASGDPIPS--ITWRTSTR---NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
E G PI S + R ++R + SE+ ++S V++ ++ +Y +
Sbjct: 20497 LEDGGSPIKSYILEKRETSRLLWTVVSED--------IQSCRHVATKLIQGNEYI----F 20544
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--- 440
+A N G+ V+ + P E + V +AT+SW R
Sbjct: 20545 RVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKN-------TATVSWKRPVD 20597
Query: 441 DG---------QLLPSSNYSNIKIYNTP-SASYLEVTPDSENDFGNYNCTAVNRIG---- 486
DG + + ++ TP S +VT E + +A NR G
Sbjct: 20598 DGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPP 20657
Query: 487 QESLEFILVQ--ADTPSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543
E+ + +L++ A P PS V + +A + + +P GG+ I Y E + VG+E
Sbjct: 20658 SEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
W + +V L+ + Y R++A+N G+GE
Sbjct: 20718 AWIKDTTGTALRITQFVVP--DLQTKEKYNFRISAINDAGVGE 20758
Score = 56.6 bits (135), Expect = 8e-08
Identities = 88/424 (20%), Positives = 155/424 (36%), Gaps = 57/424 (13%)
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G I AR EI+ + + I +V+A G++ L D G P P + W+KD
Sbjct: 24694 GAITARDEIDAPNASLDPKYKDVI-----VVHA----GETFVLEADIRGKPIPDVVWSKD 24744
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
G+++E+ + + + L +K + D +YI N G + I +KV +P
Sbjct: 24745 GKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPG- 24803
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
+ +++ C + +P P + + E++ + V +L
Sbjct: 24804 ---PPEGPLKVTGVTAEKCYLAWNP-PLQDGGANISHYIIEKRETSRLSWTQVSTEVQAL 24859
Query: 371 TLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAV---YTWEGNQVNIT 425
K + EYI A N G P GPV Y G
Sbjct: 24860 NYKVTKLLPGNEYIFRVMAVNKYGIGE----------PLESGPVTACNPYKPPGPPSTPE 24909
Query: 426 CEVFAYPSATISWFR---------DGQLLPSSNYSNIK----IYNTPSASYLEVTPDSEN 472
S ++W R +G +L + ++ T + L VT +E
Sbjct: 24910 VSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 24969
Query: 473 DFGNYNCTAVNR--IGQESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPE 523
+ A N +G+ S + +A PS+P + + S+ + + +P
Sbjct: 24970 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKV--TDTSRSSVSLAWSKPI 25027
Query: 524 ATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG-IVTIVGLKPETTYAVRLAALNGK 582
GG P+ Y E + + W + ++G T+ LK T Y R+ A+N +
Sbjct: 25028 YDGGAPVKGYVVEVKEAAADEWTT---CTPPTGLQGKQFTVTKLKENTEYNFRICAINSE 25084
Query: 583 GLGE 586
G+GE
Sbjct: 25085 GVGE 25088
Score = 56.6 bits (135), Expect = 8e-08
Identities = 72/324 (22%), Positives = 121/324 (37%), Gaps = 44/324 (13%)
Query: 22 VDIVPSQGEI--SVGESKF---FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDD 76
++I P G+I +VGE ++C++ + ++W+ G + N ++ + + +D
Sbjct: 31565 IEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYF--GVRQLENSEKYEITY-ED 31621
Query: 77 SSSTLTIYNANIDDAGIYKCVVT---GEDGSESEATVN---------VKIFQKLMFKNAP 124
+ L + + D G Y+C V GED S +E V + K + +
Sbjct: 31622 GVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTD 31681
Query: 125 T------PQEFR---------EGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-KKDVRFIV 168
T P EF GE+ + P + W G+ + D ++
Sbjct: 31682 TMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTF 31741
Query: 169 LSNN---YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA-----RQNI 220
S+ L I + D+ Y R + + V ++ PPT ++ +
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
NA GQSV G P PT+ W KDG+ + + E D L I+
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861
Query: 281 DEAEYICIAENKAGEQDATIHLKV 304
D Y A N AG HL+V
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 56.6 bits (135), Expect = 8e-08
Identities = 77/402 (19%), Positives = 135/402 (33%), Gaps = 110/402 (27%)
Query: 105 ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
E T +K P EGE A CD PT+ W KG+ +L
Sbjct: 32548 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ--VLSTSA 32605
Query: 165 RFIVLSNNY---LQIRGIKKTDEGTY-----RCEGRILARGEINFKDIQV---IVNVPPT 213
R V + Y +I ++ +DEG Y EG+ A + + +V V PP
Sbjct: 32606 RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR 32665
Query: 214 IQARQNIVNATANLGQSVTL----------VCDAEGFPEPT------------------- 244
+++ + V + + + V E P PT
Sbjct: 32666 VKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLK 32725
Query: 245 -----------------------MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281
++W KDG+++++ + + +D + +L I + ++D
Sbjct: 32726 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESD 32785
Query: 282 EAEYIC-----------------------------IAENKAGEQ---DATIHLK------ 303
+ EY+C I+E K +Q ++T+ K
Sbjct: 32786 QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP 32845
Query: 304 --VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV 361
+ +KP I T + + +A+G+P P+ W + I T G +
Sbjct: 32846 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-----TQGGKYKL 32900
Query: 362 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
L + +D+G Y CT N+ G S S L ++
Sbjct: 32901 SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 2/101 (1%)
Query: 209 NVPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
NVPP I + + T G +V L G P PT+SW KDG ++ E K
Sbjct: 19290 NVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI-KMAMQR 19348
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+ L + V++ D +Y AEN +G + ATI LKV KP
Sbjct: 19349 NLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 56.2 bits (134), Expect = 1e-07
Identities = 70/304 (23%), Positives = 101/304 (33%), Gaps = 45/304 (14%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + I ++ P ISW +DG + + +I +T + + L V D G Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIISTDNHTLLTVKDCIRRDTGQYV 25861
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
T N G S+ D P P+ +E TA+ + + P+ GG I Y
Sbjct: 25862 LTLKNVAGTRSVAVNCKVLDKPGPPA-GPLEINGLTAEKCSLSWGRPQEDGGADIDYYIV 25920
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
E R E H W + + L Y R+ +N G+GE + K
Sbjct: 25921 EKR----ETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKA 25976
Query: 596 QPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKV 655
+ P P ++ T V W P
Sbjct: 25977 LDPFTVPSPPTSLEITSVTKESMTLCWSRP------------------------------ 26006
Query: 656 NLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQ 714
+ DGGS I Y++ R +S W + P V L EYE V AEN
Sbjct: 26007 ----ESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENA 26062
Query: 715 QGKS 718
G S
Sbjct: 26063 AGLS 26066
Score = 55.8 bits (133), Expect = 1e-07
Identities = 74/337 (21%), Positives = 118/337 (35%), Gaps = 58/337 (17%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE------- 471
G+Q+ I + P+ SW DG+ + +++ P + LE +S
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDG---VHDIPEDAQLETAENSSVIIIPEC 15881
Query: 472 --NDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGV 528
+ G Y+ TA N+ GQ++ + D P P +V + + ++ + P+ GG
Sbjct: 15882 KRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGD 15941
Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
I Y E R + + W D + + L E Y R+ A N G+G
Sbjct: 15942 RIKGYVIEKRTIDGKAWTKVNPDCGSTTF----VVPDLLSEQQYFFRVRAENRFGIG--- 15994
Query: 589 AASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP-ALATTEPAKGEPSAPKLEGQMG 647
PP ++ P+ PPD L L T PK
Sbjct: 15995 ------------PPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPK------ 16036
Query: 648 EDGNSIKVNLIKQDDGGSPIRHYLVRYRA------LSSEWKPEIRLPSGSDHVMLKSLDW 701
+DGGSP+ HY+V A W+ + ++ L
Sbjct: 16037 -------------NDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVE 16083
Query: 702 NAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPATL 738
EYE V A N G SK + V Q +P ++
Sbjct: 16084 GGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSI 16120
Score = 55.8 bits (133), Expect = 1e-07
Identities = 94/418 (22%), Positives = 148/418 (35%), Gaps = 81/418 (19%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L G P+P+++W+ + E + + + +L L S+ D+G+Y
Sbjct: 19313 VCLDATVFGKPMPTVSWKKDGTLLKPAEG-----IKMAMQRNLCTLELFSVNRKDSGDYT 19367
Query: 385 CTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY---- 431
TA N+ G S ++ L+V P K+ A+ +WE + E+ Y
Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427
Query: 432 -PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
++ +W + +P ++ S K+ E + A N+ G
Sbjct: 19428 RETSRPNWAQVSATVPITSCSVEKLI--------------EGHEYQFRICAENKYGVGDP 19473
Query: 491 EFILVQ-ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAEWRAVGEEV 544
F A P P P S V + P GG PI Y E R
Sbjct: 19474 VFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVN 19533
Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE--FKTQPVHSPP 602
W ++ +E + GL+ T Y R+ A+N G G+ S AS+ + P + P
Sbjct: 19534 WTKV---NRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPG 19590
Query: 603 PPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDD 662
PPA DTT +L+ +PA D
Sbjct: 19591 PPAFPKVY--------DTTRSSVSLSWGKPAY---------------------------D 19615
Query: 663 GGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLK--SLDWNAEYEVYVVAENQQGKS 718
GGSPI YLV + S+ LP + L + +Y+ V A N+ G S
Sbjct: 19616 GGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYS 19673
Score = 55.8 bits (133), Expect = 1e-07
Identities = 97/474 (20%), Positives = 170/474 (35%), Gaps = 82/474 (17%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDA-TIHLKVFAK-----PKITYVENQTAMELE 322
S Q I + + +E + +A N+ G D ++ + + AK P + + ++++
Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
+ + + SG P P+ITW + + + V +++L++K D G+
Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQTTR-----INVTDSLDLTTLSIKETHKDDGGQ 23299
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y T +N +GQ + S+ + P +GPV + ++ Y +
Sbjct: 23300 YGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGC----QI 23355
Query: 442 GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIGQE-SLEFILVQ 496
+ + +++ SA+ L+VT + A NR GQ +LE +
Sbjct: 23356 TNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIV 23415
Query: 497 ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAE--------WRAVGEE 543
A P P+++ +Q+ EP GG P++ Y E W V +
Sbjct: 23416 AQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKT 23475
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
+ H + A+ EGI Y R+ A N G+G+ S SE PP
Sbjct: 23476 IIHDTQFKAQNLE-EGI----------EYEFRVYAENIVGVGKASKNSECYVARDPCDPP 23524
Query: 604 PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDG 663
+ P+ + + T L T+P DG
Sbjct: 23525 ----GTPEPIMVKRNEIT-----LQWTKPVY---------------------------DG 23548
Query: 664 GSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
GS I Y+V R L W + L + YE V+A+N G
Sbjct: 23549 GSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG 23602
Score = 55.8 bits (133), Expect = 1e-07
Identities = 93/411 (22%), Positives = 146/411 (35%), Gaps = 65/411 (15%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ LT G P P W ++IS M+ S + L +K D+G Y
Sbjct: 30154 IRLTIPIKGKPFPICKWTKEGQDISKRA------MIATSETH-TELVIKEADRGDSGTYD 30206
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
N G+ +++Y++V+ P ++ QV + P+ G +
Sbjct: 30207 LVLENKCGK--KAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYI 30264
Query: 445 LPSSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFI---- 493
L Y S + L V EN ++ +A N+ G +S E +
Sbjct: 30265 LERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 30324
Query: 494 -LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW--HSKWY 550
L + PS+P + ++ S+ + + P+ GG + Y E + + W H+K
Sbjct: 30325 PLNPPEPPSNPP-EVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQ 30383
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSS 610
+ T+ GL P+ Y R+ A N GL E S ASE
Sbjct: 30384 ITTT-----MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASE------------------ 30420
Query: 611 TPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRH 669
PV P +PS P + +S+ + K + DGG I
Sbjct: 30421 -PVVCKDPFD---------------KPSQPGELEILSISKDSVTLQWEKPECDGGKEILG 30464
Query: 670 YLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
Y V YR S WK + + L EYE V AEN+ G S+
Sbjct: 30465 YWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSR 30515
Score = 55.5 bits (132), Expect = 2e-07
Identities = 85/378 (22%), Positives = 146/378 (38%), Gaps = 52/378 (13%)
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE---QDATI---------HLKV 304
EE+ + + S Q + K + + E + AEN+ GE + T+ L +
Sbjct: 19925 EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDL 19984
Query: 305 FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
P + Y+ + + L G P PS++W+ +++ D + V S
Sbjct: 19985 KGLPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLAT-----DTRVSVESS 20034
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVN 423
A ++L + Q +DAG+Y T N G ++ ++V P + GP+ +
Sbjct: 20035 AVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMT 20094
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA---SYLEVTPDSENDFGNYNCT 480
+ +A P +L + N K SA + VT E + +
Sbjct: 20095 LK---WAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVS 20151
Query: 481 AVNRIG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
A N+ G E L+ + A D P P+I V+ + + + +P+ TGG PI
Sbjct: 20152 AENKYGVGEGLKSEPIVARHPFDVPDAPPPPNI--VDVRHDSVSLTWTDPKKTGGSPITG 20209
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGI----VTIVGLKPETTYAVRLAALNGKGLGEIS 588
Y E++ +W K A+ I + GL Y R+ A+N G+G+ S
Sbjct: 20210 YHLEFKERNSLLW-------KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS 20262
Query: 589 AASE--FKTQPVHSPPPP 604
SE P+ P P
Sbjct: 20263 LPSEPVVALDPIDPPGKP 20280
Score = 55.5 bits (132), Expect = 2e-07
Identities = 112/556 (20%), Positives = 198/556 (35%), Gaps = 113/556 (20%)
Query: 271 QLTIKKVDKNDEAEY-ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
Q T+ K+ +N E + IC ++ + AT+ V A+ +I E + +L + V L
Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121
Query: 330 EAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS----LTLKSIQY 377
A+ G P P + W + +G + R+ V+S L + ++
Sbjct: 25122 SATLRLFVTIKGRPEPEVKWEKA-----------EGILTDRAQIEVTSSFTMLVIDNVTR 25170
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
D+G Y T N G S++ ++ V+ PV N+T S T+S
Sbjct: 25171 FDSGRYNLTLENNSG--SKTAFVNVRVLDSPSAPV----------NLTIREVKKDSVTLS 25218
Query: 438 W---FRDG-----QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN----YNCTAVNRI 485
W DG + + K Y T + + + T EN + A N
Sbjct: 25219 WEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEY 25278
Query: 486 G----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
G E+ E + V + V+ +TA +++++PE+ GG I Y E + G
Sbjct: 25279 GIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKG 25338
Query: 542 EEVWHS-KWYDAKEASMEGI-------------------------VTIVGLKPETTYAVR 575
E W + EA++ G+ V ++ E +V
Sbjct: 25339 SEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVE 25398
Query: 576 LA--ALNGKGLGEISAASEFKTQP---VHSPPPPASASSSTPVPLSPPDTTWPLPALATT 630
L N K ++ FK +P V+ + +T V +S T + +L+
Sbjct: 25399 LPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT---VTSLSIK 25455
Query: 631 EPAKGEPSAPKLEGQMGEDGNSIKVNLIKQD---------------------------DG 663
E +K + +L ++ + +I D DG
Sbjct: 25456 EASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDG 25515
Query: 664 GSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHF 723
G I +Y+V + +S + + + L +EY+ V AEN+ GKS +
Sbjct: 25516 GCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSES 25575
Query: 724 VFRTSAQPTAIPATLG 739
+ P + P G
Sbjct: 25576 SAVVAEYPFSPPGPPG 25591
Score = 55.5 bits (132), Expect = 2e-07
Identities = 88/379 (23%), Positives = 141/379 (37%), Gaps = 33/379 (8%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQE-----EDDEKYIFSDDSSQLTIKKVDKNDE 282
G SV L G P PT+ W KD ++++ E+ + D + + IK D+ +
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVEN------TTDLASILIKDADRLNS 26940
Query: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
Y N G ATI +++ KP + E++TL D + +
Sbjct: 26941 GCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGA---K 26997
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT----IGQDSQSM 398
+ + E + +V H +T I EYI IG+ +S
Sbjct: 26998 ITHYIVEKRETSRVVWSMVSEHLEECIITTTKI--IKGNEYIFRVRAVNKYGIGEPLESD 27055
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN- 457
+ + A GP + N V++ P A G L + ++ +
Sbjct: 27056 SVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKV 27115
Query: 458 ---TPSASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQ--ADTPSSPS-IDQ 507
T + +VT +EN Y AVN GQ E EF D P P+ I
Sbjct: 27116 LKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRI 27175
Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567
+ S+ + + +P GG + Y E R EE W + + + E +V+ LK
Sbjct: 27176 ADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVS--NLK 27233
Query: 568 PETTYAVRLAALNGKGLGE 586
P Y R++A+N G GE
Sbjct: 27234 PGVNYYFRVSAVNCAGQGE 27252
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 14/133 (10%)
Query: 190 EGRILARGEINFKDIQVIVNV-------PPTIQARQNIVNATANL--GQSVTLVCDAEGF 240
E R+ A EI + + +NV PPTI+ R ++ T + G+ V + D G
Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 15425
Query: 241 PEPTMSWTKDGEQIEQEED-----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
P P + W+K+ IE+ D E+ S+ ++L+I K + D+ Y A N+ G
Sbjct: 15426 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Query: 296 QDATIHLKVFAKP 308
+H++V+ +P
Sbjct: 15486 VFRNVHVEVYDRP 15498
Score = 54.7 bits (130), Expect = 3e-07
Identities = 72/339 (21%), Positives = 127/339 (37%), Gaps = 20/339 (5%)
Query: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
+W KDG I +E ++I +L I V +D EY C+ E+ +T L V
Sbjct: 11150 TWMKDGSNI-RESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208
Query: 306 AKPK--ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
P + +E + + + + L+CE + + + WR + + + G +V
Sbjct: 11209 ELPVRFVKTLEEEVTVVKGQPLYLSCELNKE--RDVVWRKDGKIVVEK----PGRIVPGV 11262
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQV 422
+ +LT+ TDAG Y T N + S V+ L P+ +
Sbjct: 11263 IGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGT 11322
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
I A + I WF+ +P+ +I + YL++ D Y AV
Sbjct: 11323 AIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY---AV 11379
Query: 483 NRIGQE-SLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
G+ + L + + I+ V Y + FD + +P +W+ G
Sbjct: 11380 EIEGKRYPAKLTLGEREVELLKPIEDVTIYEKES-ASFDAEISEADIP-----GQWKLKG 11433
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
E + S + K + +T+ +K + V ALN
Sbjct: 11434 ELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALN 11472
Score = 54.7 bits (130), Expect = 3e-07
Identities = 62/306 (20%), Positives = 122/306 (39%), Gaps = 36/306 (11%)
Query: 16 TAVSLQVDIVPSQGEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVW 73
T +++D +++V E + F C + +A ++ W G + + + ++
Sbjct: 11480 TVKEIELDFAVPLKDVTVPERRQARFECVLTREA---NVIW--SKGPDIIKSSDKFDII- 11533
Query: 74 NDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGE 133
D L I ++ DD G+Y V G+ S ++ L F + Q +EGE
Sbjct: 11534 ADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGE 11589
Query: 134 DAVIVCDVVSSLPPTIIWK-----HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYR 188
A VC++ + +K H R V++ + + + L+++ + D +
Sbjct: 11590 TATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK-----THKLEMKEVTLDDISQIK 11644
Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
+ + E++ ++ P + + + TA +TL C+ + + W
Sbjct: 11645 AQVK-----ELSSTAQLKVLEADPYFTVKLH--DKTAVEKDEITLKCEVS--KDVPVKWF 11695
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQ--LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
KDGE+I KY D + L IKK D D+ EY+C + + T+ ++
Sbjct: 11696 KDGEEIVPSP---KYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIK 11752
Query: 307 KPKITY 312
K Y
Sbjct: 11753 VEKPLY 11758
Score = 54.7 bits (130), Expect = 3e-07
Identities = 102/423 (24%), Positives = 164/423 (38%), Gaps = 88/423 (20%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E + + + +G P+P I+W I EE+ + +H + LT+K D G+
Sbjct: 25805 EVLKINADIAGRPLPVISWAKD--GIEIEERARTEIISTDNH---TLLTVKDCIRRDTGQ 25859
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR- 440
Y+ T N G S ++ +V P GP+ + +T E ++SW R
Sbjct: 25860 YVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN-------GLTAE-----KCSLSWGRP 25907
Query: 441 --DGQLLPSSNYSNIKIYNTPSASYL-----------EVTPDSENDFGNYNCTAVNRIGQ 487
DG +Y ++ T ++ +VT + + + T VN+ G
Sbjct: 25908 QEDGGA--DIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGV 25965
Query: 488 -ESLEFILVQA----DTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
E LE + ++A PS P S++ + + + PE+ GG I Y E R
Sbjct: 25966 GEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKN 26025
Query: 542 EEVW----HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
W YD + S GL+ Y R+ A N GL S SE T P
Sbjct: 26026 SLRWVRVNKKPVYDLRVKS-------TGLREGCEYEYRVYAENAAGL---SLPSE--TSP 26073
Query: 598 VHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL 657
+ + PV L P PS PK+ + +I +
Sbjct: 26074 L--------IRAEDPVFLPSP------------------PSKPKI---VDSGKTTITIAW 26104
Query: 658 IKQ-DDGGSPIRHYLVRY-RALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 715
+K DGG+PI Y V Y ++ ++WK I+ G+++ + L AEY V + N+
Sbjct: 26105 VKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYT-ISGLTTGAEYVFRVKSVNKV 26163
Query: 716 GKS 718
G S
Sbjct: 26164 GAS 26166
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/300 (23%), Positives = 110/300 (36%), Gaps = 45/300 (15%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G+ + ++ + P ++W ++ + P+ +I TP S LE+ + D G Y+
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTK----ARIDVTPVGSKLEIRNAAHEDGGIYS 17288
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
T N G +++ ++ D P P ++ E + + + EP GG I Y E
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
R V W +K+ S L Y R+AA N G G P
Sbjct: 17349 RDVASAQWSPLSATSKKKSHFA----KHLNEGNQYLFRVAAENQYGRG-----------P 17393
Query: 598 VHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL 657
P P A PL PP PK + D + +
Sbjct: 17394 FVETPKPIKALD----PLHPP-------------------GPPKDLHHVDVDKTEVSLVW 17430
Query: 658 IKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
K D DGGSPI YLV Y+ ++ + + + + V + L Y V AEN G
Sbjct: 17431 NKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV-VTGLQQGKTYRFRVKAENIVG 17489
Score = 53.9 bits (128), Expect = 5e-07
Identities = 133/640 (20%), Positives = 221/640 (34%), Gaps = 102/640 (15%)
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
G I KD + + + R IV N G++ L D G P PT+ W + ++IE+
Sbjct: 23612 GPITAKDEVELPRISMDPKFRDTIV---VNAGETFRLEADVHGKPLPTIEWLRGDKEIEE 23668
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E +D + L +K + D +YI A N AG + +++KV +P Q
Sbjct: 23669 SARCE-IKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQ 23727
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
E+ +LT P+ S + E + VV S +S LK +
Sbjct: 23728 VTGVTSEKCSLTW---SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS--LKVTK 23782
Query: 377 YTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
+ EY+ A N G ++ AP L V + +T A S
Sbjct: 23783 LLEGNEYVFRIMAVNKYGVGE-----PLESAPVLMKNPFVLPGPPKSLEVT--NIAKDSM 23835
Query: 435 TISWFRD---------GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTA 481
T+ W R G ++ + S I+ L VT +E+ + +A
Sbjct: 23836 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 23895
Query: 482 VNR--IGQESLEFILVQADTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
N +G+ S + +A P + V+ ++ + + +P GG IL Y
Sbjct: 23896 ENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYV 23955
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEF 593
E EE W + + I L Y +R+ ALN GLGE S
Sbjct: 23956 VEICKADEEEW--QIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTV 24013
Query: 594 KTQPVHSPPP-------------PASASSSTPVPLS---PPDTTWPLPALATTEPAKGEP 637
K + P A S+ +P P+ TW T+ + E
Sbjct: 24014 KPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEK 24073
Query: 638 SAP-------------------KLEGQMGEDG--------------NSIKVNLIKQD--- 661
KLE G ++ V +++D
Sbjct: 24074 GVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAF 24133
Query: 662 --------DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 713
DGG+ +++Y++ R + + + +++L A Y V+AEN
Sbjct: 24134 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 24193
Query: 714 QQGKSKAAHFVFRT-SAQPTAIPATLGGNSASYTFVSLLF 752
+ G V +A+P + P + S T SL++
Sbjct: 24194 EFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMW 24233
Score = 53.9 bits (128), Expect = 5e-07
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 9/113 (7%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ KDI + + R +++ A G+ V ++ +G P PT++W KD + +
Sbjct: 27260 VQAKDILEAPEIDLDVALRTSVI---AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGS-- 27314
Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKP 308
D +Y +D SS LTI +V +ND +YI EN GE + +T+ +KV P
Sbjct: 27315 -DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTP 27366
Score = 53.5 bits (127), Expect = 7e-07
Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 1/81 (1%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G+ + + D G P P +SW KDG +IE+ E I +D+ + LT+K + D +Y+
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTE-IISTDNHTLLTVKDCIRRDTGQYVL 25862
Query: 288 IAENKAGEQDATIHLKVFAKP 308
+N AG + ++ KV KP
Sbjct: 25863 TLKNVAGTRSVAVNCKVLDKP 25883
Score = 53.5 bits (127), Expect = 7e-07
Identities = 101/476 (21%), Positives = 166/476 (34%), Gaps = 110/476 (23%)
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+T G P+P++ W S + L V + +SLT+++ D+G+Y
Sbjct: 26205 TMTVPFRGRPVPNVLW-------SKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDG 442
T N + S ++ ++V P G NIT + SA +SW DG
Sbjct: 26258 TIQNVLSAASLTLVVKVLDTP------------GPPTNITVQDVTKESAVLSWDVPENDG 26305
Query: 443 QLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488
P NY + + + N + +VT E + + N G E
Sbjct: 26306 G-APVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAE 26364
Query: 489 SLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
+ E + + + PS P V S + + + +PE GG I+ Y E G++ W
Sbjct: 26365 TKEGVKI-TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNW-V 26422
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE--------------------- 586
K AK + GL+ + Y R+ A N GL +
Sbjct: 26423 KCAVAKSTHH----VVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDM 26478
Query: 587 ---------ISAASEFKTQ-PVHSPPPPASASSSTPVPL----------SPPDTTWPLPA 626
+ A S K P+ P P S VPL + + T L
Sbjct: 26479 KNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKE 26538
Query: 627 LATTEPAK------------------------GEPSAPKLEGQMGEDGNSIKVNLIKQDD 662
T + + G P+ P + + E+ ++K K D
Sbjct: 26539 SVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKY-D 26597
Query: 663 GGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 718
GGS + +Y++ R S+ E+ + + L EY+ + AEN+ G S
Sbjct: 26598 GGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS 26653
Score = 53.1 bits (126), Expect = 9e-07
Identities = 65/262 (24%), Positives = 99/262 (37%), Gaps = 45/262 (17%)
Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQFD 520
++L + + +D G Y+ T VN G++++ + DTP S +V + T+ V +
Sbjct: 18661 AFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWA 18720
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
PE GG + Y E R + W + + K+ S + L P Y R+ A+N
Sbjct: 18721 PPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFH----VTNLVPGNEYYFRVTAVN 18776
Query: 581 GKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAP 640
G G P P P ++ PLS PD P L TE K +
Sbjct: 18777 EYGPG----------VPTDVPKPVLASD-----PLSEPD---PPRKLEVTEMTKNSATLA 18818
Query: 641 KLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSD----HVML 696
L DGG+ I Y+ YR E +P R S +++
Sbjct: 18819 WLP---------------PLRDGGAKIDGYITSYR---EEEQPADRWTEYSVVKDLSLVV 18860
Query: 697 KSLDWNAEYEVYVVAENQQGKS 718
L +Y+ V A N G S
Sbjct: 18861 TGLKEGKKYKFRVAARNAVGVS 18882
Score = 53.1 bits (126), Expect = 9e-07
Identities = 79/349 (22%), Positives = 127/349 (36%), Gaps = 63/349 (18%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE------- 322
++ T+ + +E ++ A N AG+ D+ I V+ TA EL+
Sbjct: 28311 TRYTVTDLQAGEEYKFRVSAINGAGKGDSCE-----VTGTIKAVDRLTAPELDIDANFKQ 28365
Query: 323 -------EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ L G P P+ W N+S + + S+LT+++
Sbjct: 28366 THVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD-------IHTTDSFSTLTVENC 28418
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
DAG+Y T N G S + ++V P GP IT + SAT
Sbjct: 28419 NRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP------------ITFKDVTRGSAT 28466
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE---------NDFGN-----YNCTA 481
+ W D LL + + AS SE ND + +A
Sbjct: 28467 LMW--DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSA 28524
Query: 482 VNRIG---QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
VN G + +V + P+ P +D V+ S+A + + +P+ GG I Y E
Sbjct: 28525 VNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM 28584
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
R G + W + + + T+ L +T Y R+ A N G E
Sbjct: 28585 RQKGSDFWVEAGH-----TKQLTFTVERLVEKTEYEFRVKAKNDAGYSE 28628
Score = 52.8 bits (125), Expect = 1e-06
Identities = 130/674 (19%), Positives = 252/674 (37%), Gaps = 84/674 (12%)
Query: 14 LGTAVSLQVD---IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRIS 70
LG + L V+ I+ +++ E+ +V+ + WF + E ++ R+
Sbjct: 2784 LGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLV 2843
Query: 71 VVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR 130
++ L + N + DAG Y VV G+ +++ V K M KN P
Sbjct: 2844 ---SERKVHKLMLQNISPSDAGEYTAVV-GQLECKAKLFVETLHITKTM-KNIEVP---- 2894
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRC 189
E + A C+V P++ W G ++ + + + +V + L I D Y
Sbjct: 2895 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 2953
Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ +++ + P I + +NA + + + EG + W K
Sbjct: 2954 ---VCGNDQVS----ATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLK 3003
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G +I+ + + S L I+ V D A+Y +A AT++++
Sbjct: 3004 NGVEIKSTDKCQMRTKKLTHS-LNIRNVHFGDAADYTFVAGKATST--ATLYVEARHIEF 3060
Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
++++ +E +++ CE S +P ++ W +E + + ++ V
Sbjct: 3061 RKHIKDIKVLE-KKRAMFECEVS-EPDITVQWMKD-----DQELQITDRIKIQKEKYVHR 3113
Query: 370 LTLKSIQYTDAGEYICTASNTI--------GQD--SQSMYLEVQYAPKLQGPVAVYTWEG 419
L + S + +DAG+Y A + G+D +S+ EVQ K + AV +E
Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQR---AVVEFEV 3170
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
N+ ++ W++DG + K + ++ ++D G Y
Sbjct: 3171 NEDDVDAH----------WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF 3220
Query: 480 TAVNRIGQESLEFILVQADTPSSPSI-DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
A + + + + P P + +++P + VQ +P V + + +
Sbjct: 3221 VA-----GRNRSSVTLYVNAPEPPQVLQELQPVT----VQSGKPARFCAVISGRPQPKIS 3271
Query: 539 AVGEEVWHSKWYDAK--EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596
EE S + K E + ++ PE A N G+ SA+ +
Sbjct: 3272 WYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVP 3331
Query: 597 PVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
V SP +P+ PP PL T+E G+P+ Q G +KV+
Sbjct: 3332 EVVSP--------DQEMPVYPPAIITPLQDTVTSE---GQPA----RFQCRVSGTDLKVS 3376
Query: 657 LIKQDDGGSPIRHY 670
+D P R +
Sbjct: 3377 WYSKDKKIKPSRFF 3390
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/420 (20%), Positives = 166/420 (39%), Gaps = 38/420 (9%)
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVT 326
+ + + ++K+ + E + A NKAG + A + + + K+ + +EL + +
Sbjct: 22894 NKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIIN 22953
Query: 327 LTCEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+ S G P P + W I ++ + +SL L ++
Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAA-------IIDVTSSFTSLVLDNVNRY 23006
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE--VFAYPSATI 436
D+G+Y T N+ G S + + V P + V + V+IT E + S
Sbjct: 23007 DSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEF 492
++ + + +Y+ + + N S+ ++ E + TA N G ++ +
Sbjct: 23067 NYIVEKREATRKSYAAV-VTNCHKNSW-KIDQLQEGCSYYFRVTAENEYGIGLPAQTADP 23124
Query: 493 ILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 551
I V A+ P P V+ + ++ + + +PE GG I++Y E +A E W
Sbjct: 23125 IKV-AEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE---C 23180
Query: 552 AKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE---ISAASEFKTQPVHSPPPPASAS 608
A+ S++ ++T L Y R+ A+N KG + ++ K + PA +S
Sbjct: 23181 ARVKSLQAVIT--NLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSS 23238
Query: 609 SSTPV----PLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGG 664
S V + P + P P + T+ ++ D ++ + +DDGG
Sbjct: 23239 YSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 69/294 (23%), Positives = 114/294 (38%), Gaps = 25/294 (8%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L SG P P+I W + + + + + V + ++S+ +K ++G Y
Sbjct: 26890 VKLRAGISGKPAPTIEWYKDDKELQT-----NALVCVENTTDLASILIKDADRLNSGCYE 26944
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
N +G S ++ +++ P G P+ T ++ + P A +
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWR----PPADDGGAKITH 27000
Query: 444 LLPSSNYSNIKIYNTPSASYLE-VTPDSENDFGN---YNCTAVNRIG-QESLEFILVQAD 498
+ ++ +++ S E + ++ GN + AVN+ G E LE V A
Sbjct: 27001 YIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAK 27060
Query: 499 ----TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
TP P I +V + + V + P A GG I Y E R W K
Sbjct: 27061 NAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKV---LK 27117
Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KTQPVHSPPPPA 605
E + + GL + Y R+ A+N G G S SEF P+ P PPA
Sbjct: 27118 ETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPA 27171
Score = 52.0 bits (123), Expect = 2e-06
Identities = 65/302 (21%), Positives = 108/302 (35%), Gaps = 42/302 (13%)
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
N + I YP T +W ++L + + +K+ + + L ++P +D G Y
Sbjct: 13410 NPITILVPSTGYPRPTATWCFGDKVLETGD--RVKMKTLSAYAELVISPSERSDKGIYTL 13467
Query: 480 TAVNRIGQESLEFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
NR+ S E + PS+P + + + + ++ P+ GG P+ Y E R
Sbjct: 13468 KLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKR 13527
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598
V + W + T+ L Y ++ A N G GE + E
Sbjct: 13528 EVSRKTWTKVMDFVTDLEF----TVPDLVQGKEYLFKVCARNKCGPGEPAYVDE------ 13577
Query: 599 HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNL- 657
P + S+ VP P + W NSI +
Sbjct: 13578 -----PVNMSTPATVPDPPENVKW-----------------------RDRTANSIFLTWD 13609
Query: 658 IKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 717
++DGGS I+ Y+V S+ P + + L+ Y V A N+QG
Sbjct: 13610 PPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGA 13669
Query: 718 SK 719
SK
Sbjct: 13670 SK 13671
Score = 51.6 bits (122), Expect = 3e-06
Identities = 68/326 (20%), Positives = 111/326 (34%), Gaps = 45/326 (13%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + + P+ ++W +D +P + + +T + S L + D G+Y
Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYV 22219
Query: 479 CTAVNRIGQ--ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
N G+ E+L I++ P + + E + + + + P+ GG I Y E
Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596
R W +++ LK Y R+AA N G K+
Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKAC----RLKTGCEYQFRIAAENRYG----------KST 22325
Query: 597 PVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVN 656
++S P A P PP T P+ L++ D ++ N
Sbjct: 22326 YLNSEPTVAQYPFKVP---GPPGT--PVVTLSS------------------RDSMEVQWN 22362
Query: 657 LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
D G I ++L R S W + P L+ EYE V AEN G
Sbjct: 22363 EPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 22422
Query: 717 KSKAAH----FVFRTSAQPTAIPATL 738
K + +V R P P +
Sbjct: 22423 IGKPSKVSECYVARDPCDPPGRPEAI 22448
Score = 51.2 bits (121), Expect = 4e-06
Identities = 47/182 (25%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK---DVRFIVLSNNY-LQIRGIKKTDEGT 186
+G ++ V P T W +D ++++ V ++ N Y +I+ EG
Sbjct: 17830 DGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEG- 17888
Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMS 246
E R LA I KDI V + R I T +GQ++ ++ +G PEP ++
Sbjct: 17889 ---EPRELAESVIA-KDILHPPEVELDVTCRDVI---TVRVGQTIRILARVKGRPEPDIT 17941
Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
WTK+G+ + +E+ + I +L IK+ + D +YI A+N +G + + V
Sbjct: 17942 WTKEGKVLVREKRVD-LIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLD 18000
Query: 307 KP 308
+P
Sbjct: 18001 RP 18002
Score = 51.2 bits (121), Expect = 4e-06
Identities = 111/483 (22%), Positives = 178/483 (36%), Gaps = 61/483 (12%)
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
W R L+ + + YL R + ++G R + R LA I KD+ + +V
Sbjct: 23177 WSECARVKSLQAVITNLTQGEEYL-FRVVAVNEKG--RSDPRSLAV-PIVAKDLVIEPDV 23232
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
P + + +GQ + + G P+PT++WTKDG ++Q S D +
Sbjct: 23233 KPAFSSY------SVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ-TTRINVTDSLDLT 23285
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L+IK+ K+D +Y N G++ A+I + KP + E +TL
Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL--- 23342
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTAS 388
S +P P T N +++ + A V+ TLK + EY A
Sbjct: 23343 -SWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAE 23400
Query: 389 NTIGQD--SQSMYLEVQYAPKLQGPVA------------VYTWEGNQVNITCEVFAY--- 431
N GQ +S + QY K GP V W N V Y
Sbjct: 23401 NRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLE 23460
Query: 432 --PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
+I W + + + + + K N E +EN G V + + S
Sbjct: 23461 RKERNSILWTKVNKTI--IHDTQFKAQNLEEGIEYEFRVYAENIVG------VGKASKNS 23512
Query: 490 LEFILVQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548
++ D P +P V+ T +Q+ +P GG I Y E R + + +
Sbjct: 23513 ECYVARDPCDPPGTPEPIMVKRNEIT--LQWTKPVYDGGSMITGYIVEKRDLPD----GR 23566
Query: 549 WYDAKEAS-MEGIVTIVGLKPETTYAVRLAALNGKG--------LGEISAASEFKTQPVH 599
W A + +E T+ GL + Y R+ A N G G I+A E + +
Sbjct: 23567 WMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRIS 23626
Query: 600 SPP 602
P
Sbjct: 23627 MDP 23629
Score = 50.8 bits (120), Expect = 5e-06
Identities = 92/412 (22%), Positives = 150/412 (36%), Gaps = 60/412 (14%)
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPKLQGPVAVYTW 417
V H + + T++ + E+ A N G + ++ + P+++ P A T
Sbjct: 28593 VEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE-PTADLTG 28651
Query: 418 EGNQVNITCE----------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
NQ+ ITC+ + P+ ++W + L ++ + I T + L V
Sbjct: 28652 ITNQL-ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETD--RVSITTTKDRTTLTVK 28708
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEA 524
D G Y T N G ++ +V P P +E S +A+ + + EP+
Sbjct: 28709 DSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG-PVTGPIEVSSVSAESCVLSWGEPKD 28767
Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGL 584
GG I Y E R G W K + + L Y+ R+++ N G+
Sbjct: 28768 GGGTEITNYIVEKRESGTTAWQLVNSSVKRTQ----IKVTHLTKYMEYSFRVSSENRFGV 28823
Query: 585 GEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEG 644
++P+ S P A P PP A T P SA +
Sbjct: 28824 ----------SKPLESAPIIAEH------PFVPPS--------APTRPEVYHVSANAMSI 28859
Query: 645 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNA 703
+ E DGGS I Y V + ++ W E ++P + + L
Sbjct: 28860 RWEE----------PYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGL 28909
Query: 704 EYEVYVVAENQQGKSKAAHFVFRTSAQ-PTAIPATLGGNSASYTFVSLLFSA 754
EY+ A N G SKA+ AQ P P + + VSL++SA
Sbjct: 28910 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSA 28961
Score = 50.4 bits (119), Expect = 6e-06
Identities = 62/287 (21%), Positives = 101/287 (35%), Gaps = 45/287 (15%)
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
P I+W + L +IK +T ++L ++ D G Y T N G++
Sbjct: 19721 PPPKITWSKPNVNLRDRIGLDIK--STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYT 19778
Query: 492 FILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
++ DTP P ++ E +A V ++ P GG PI+ Y + R + W +
Sbjct: 19779 IVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTT 19838
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSS 610
+ + S + L+ +Y R+ A N G+G+ + P P
Sbjct: 19839 ECSKTSFR----VANLEEGKSYFFRVFAENEYGIGDPGETRD--AVKASQTPGPVVDLKV 19892
Query: 611 TPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHY 670
V S W P DGGS I Y
Sbjct: 19893 RSVSKSSCSIGWKKP----------------------------------HSDGGSRIIGY 19918
Query: 671 LVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 717
+V + ++W+ ++ S S K L EY V AEN+ G+
Sbjct: 19919 VVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENGE 19963
Score = 50.4 bits (119), Expect = 6e-06
Identities = 92/436 (21%), Positives = 166/436 (38%), Gaps = 79/436 (18%)
Query: 244 TMSWTK---DGE--------QIEQEEDDEKYIFSDDSS----QLTIKKVDKNDEAEYICI 288
+++WTK DG ++++++ D+ Y +++ + T+ + + +
Sbjct: 29359 SLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVA 29418
Query: 289 AENKAGEQDATIHL-KVFAKPKITYVENQTAMELEEQVTLTCEAS--------GDPIPSI 339
A N G + + + ++ +I + + A +L++ VT+ AS G P P I
Sbjct: 29419 AVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVI 29478
Query: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY 399
TW S + L ++ + S L + + DAG+Y A N G+ S ++
Sbjct: 29479 TW-------SKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVL 29531
Query: 400 LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPS-------------ATISWFRDGQLLP 446
++V P V V + V IT E+ A + F+
Sbjct: 29532 VKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKC 29591
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ--ESLEFILVQADTPSSPS 504
S I + Y V P EN +G IG+ E+ + +LV ++ P P+
Sbjct: 29592 SKTLYRISGLVEGTMYYFRVLP--ENIYG---------IGEPCETSDAVLV-SEVPLVPA 29639
Query: 505 -IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 563
++ V+ ST + +++P GG + Y E G E W K K +E T+
Sbjct: 29640 KLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERW-MKVVTLKPTVLEH--TV 29696
Query: 564 VGLKPETTYAVRLAALNGKGLGE--------------ISAASEFKTQPVHSPPPPASASS 609
L Y R+ A N KG+ E + + T P + PA
Sbjct: 29697 TSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPV 29756
Query: 610 STPVPLS---PPDTTW 622
+P++ PP +W
Sbjct: 29757 ELVIPIAGRPPPAASW 29772
Score = 50.1 bits (118), Expect = 8e-06
Identities = 103/491 (20%), Positives = 176/491 (35%), Gaps = 98/491 (19%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-----KPKITYVE--NQTAMEL 321
S + T+K + + D EY A N G+ + K P +++ ++ + +
Sbjct: 16773 SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRV 16832
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK----SIQY 377
E LT SG P P ++W ++ +++T H + + TL +
Sbjct: 16833 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRT---------HIKTTPATLALEKIKAKR 16883
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
+D+G+Y N+ G S+ + +V + PV +++ +T + IS
Sbjct: 16884 SDSGKYCVVVENSTG--SRKGFCQVNVVDRPGPPVGPVSFD----EVTKDYMV-----IS 16932
Query: 438 W---FRDGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
W DG +NY K + + + + +V+ E + A N
Sbjct: 16933 WKPPLDDGGS-KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENL 16991
Query: 485 IG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
G + L ++A D P P + +V +A V +++P GG PI Y E
Sbjct: 16992 YGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVT--KDSALVTWNKPH-DGGKPITNYILE 17048
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE--FK 594
R + W D + + L Y R++A N G+G+ S S+ F
Sbjct: 17049 KRETMSKRWARVTKDPIHPYTK--FRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFA 17106
Query: 595 TQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIK 654
P+ P PP + + + D TW P
Sbjct: 17107 KDPIAKPSPPVNPEA-IDTTCNSVDLTWQPP----------------------------- 17136
Query: 655 VNLIKQDDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVMLK--SLDWNAEYEVYVVA 711
+ DGGS I Y+V Y+ + EW+ P K L Y+ V+A
Sbjct: 17137 -----RHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLA 17191
Query: 712 ENQQGKSKAAH 722
N G+S AH
Sbjct: 17192 VNAAGESDPAH 17202
Score = 49.7 bits (117), Expect = 1e-05
Identities = 91/375 (24%), Positives = 141/375 (37%), Gaps = 58/375 (15%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ N DD G Y GE+ + + TV K + T Q E ++AV C+
Sbjct: 2589 LTVLNMMKDDEGKYT-FYAGENMTSGKLTVAGGAISKPL-----TDQTVAESQEAVFECE 2642
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
V + W G+ + L ++R + I K D+ GE
Sbjct: 2643 VANP-DSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDD-----------IGEYT 2690
Query: 201 FKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+K + ++A ++ + N T Q + + W K+G +E
Sbjct: 2691 YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLES- 2749
Query: 258 EDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHL-----KVFAKPK- 309
+EKY S + L IK DE+ Y + G A+ L K+ KPK
Sbjct: 2750 --NEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVETVKIIKKPKD 2803
Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
+T +EN T V S D +P + W S E K D H +V S +V
Sbjct: 2804 VTALENAT-------VAFEVSVSHDTVP-VKWFHK----SVEIKPSDKHRLV-SERKVHK 2850
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEV- 428
L L++I +DAGEY + +++E + K + V E + CEV
Sbjct: 2851 LMLQNISPSDAGEYTAVVGQL--ECKAKLFVETLHITKTMKNIEVP--ETKTASFECEVS 2906
Query: 429 -FAYPSATISWFRDG 442
F PS W ++G
Sbjct: 2907 HFNVPS---MWLKNG 2918
Score = 49.7 bits (117), Expect = 1e-05
Identities = 128/609 (21%), Positives = 219/609 (35%), Gaps = 127/609 (20%)
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY----- 263
++PP+I ++ + G +V +V +G P PT++W K + ++ Y
Sbjct: 16115 DMPPSIDLKEFM---EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN 16171
Query: 264 -IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTAME 320
+ DD+ L I + ++D Y A N G + L V + P + ++ ++
Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 16231
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
+Q+TL+ D S + + I E + V S + + T+ + +
Sbjct: 16232 --DQMTLSWFPPKDDGGS---KITNYVIEKREANRKTWVHVSSEPKECTYTIPKL--LEG 16284
Query: 381 GEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
EY+ A N G + + E + A L ++ G T S T++W
Sbjct: 16285 HEYVFRIMAQNKYGI-GEPLDSEPETARNL------FSVPGAPDKPTVSSVTRNSMTVNW 16337
Query: 439 FR---DGQLLPSSNYSNIKIYNTPSASYLEVTPD-------------------SENDFGN 476
DG P + Y +++ +T S + V D S+ F
Sbjct: 16338 EEPEYDGGS-PVTGYW-LEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRV 16395
Query: 477 YNCTAVNRIGQESLEFILVQAD---TPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILK 532
Y A +G SL A P P +V ++ S+A +++ P GG +
Sbjct: 16396 YAINAAG-VGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTG 16454
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV-GLKPETTYAVRLAALNGKGL---GEIS 588
Y E++ G+E W K+ + G +V GLK Y R+ A+N G+ GE++
Sbjct: 16455 YIVEYKEEGKEEWEK----GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVT 16510
Query: 589 AASEFKTQPVHSPPPPASASSSTPVPL---------------SPPDTTW-----PLPALA 628
E K + V SP AS + + PP TW LP A
Sbjct: 16511 DVIEMKDRLV-SPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEA 16569
Query: 629 TTEPAKGEPS--------------APKLEGQMGEDGNSIKVNLI---------------- 658
T E S + + + GE +I V+++
Sbjct: 16570 TIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLT 16629
Query: 659 ----------KQDDGGSPIRHYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEV 707
+DDGGSPI +Y++ R W P + + ++ L Y
Sbjct: 16630 NESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTP-VTYTVTRQNATVQGLIQGKAYFF 16688
Query: 708 YVVAENQQG 716
+ AEN G
Sbjct: 16689 RIAAENSIG 16697
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/210 (21%), Positives = 77/210 (36%), Gaps = 10/210 (4%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + + P+ TI W++D + L ++ + + + NT + + + + G Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYE 26944
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
N +G S + D P P +E + TA+ + + P GG I Y
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPG-GPIEFKTVTAEKITLLWRPPADDGGAKITHYIV 27003
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
E R VW E E I+T + Y R+ A+N G+GE +
Sbjct: 27004 EKRETSRVVWSM----VSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059
Query: 596 QPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
+ P P T + + W P
Sbjct: 27060 KNAFVTPGPPGIPEVTKITKNSMTVVWSRP 27089
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/438 (21%), Positives = 165/438 (37%), Gaps = 35/438 (7%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
DI+ ++ E VG S F C V+ I+ + +G + + + + D L
Sbjct: 11123 DIILTESEF-VGSSAIFECLVSPSTA---ITTWMKDGSNIRESPKHRFIA--DGKDRKLH 11176
Query: 83 IYNANIDDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
I + + DAG Y CV+ G S A + V+ K +G+ + C++
Sbjct: 11177 IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL 11236
Query: 142 VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
+ ++W+ G+ V+ K + V ++ L I TD GTY +
Sbjct: 11237 --NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTY-----TVTVENA 11289
Query: 200 NFKDIQVIVNVPPTIQ--ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
N + V V I+ + I + + CD P + W K ++I E
Sbjct: 11290 NNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAE 11348
Query: 258 EDDEKYIFSDDSS-QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
+D+ I D + L IK D AEY E K A + L + +E+
Sbjct: 11349 PNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGK--RYPAKLTLGEREVELLKPIEDV 11406
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
T E +E + E S IP W+ + E +++ LTL ++
Sbjct: 11407 TIYE-KESASFDAEISEADIPG-QWK-----LKGELLRPSPTCEIKAEGGKRFLTLHKVK 11459
Query: 377 YTDAGEYICTASNTIGQDSQSM-YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
AGE + A N I ++ +E+ +A L+ V E Q C + A
Sbjct: 11460 LDQAGEVLYQALNAITTAILTVKEIELDFAVPLKD---VTVPERRQARFECVLTR--EAN 11514
Query: 436 ISWFRDGQLLPSSNYSNI 453
+ W + ++ SS+ +I
Sbjct: 11515 VIWSKGPDIIKSSDKFDI 11532
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/304 (23%), Positives = 114/304 (37%), Gaps = 22/304 (7%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
I KD V ++ R IV + G + ++ G P PT++W + + QE
Sbjct: 16513 IEMKDRLVSPDLQLDASVRDRIV---VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEA 16569
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
E S S + IK ++ + Y +A+N+AGE+ TI + V P
Sbjct: 16570 TIETTAIS---SSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAH 16626
Query: 319 MELEEQVTLTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
E LT + D P + R T + V R +A V L
Sbjct: 16627 NLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAY 16686
Query: 377 YTDAGEYICTASNTIG-----QDSQSMYL-EVQYAPKLQGPVAVYTWEGNQVNITCEVFA 430
+ + A N+IG + S+++ + E P+ + V N V +T
Sbjct: 16687 F-----FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPK 16741
Query: 431 YP--SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
Y S I++ + +L+ + + + N S Y V E D Y +AVN +GQ
Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKY-TVKGLKEGDTYEYRVSAVNIVGQG 16800
Query: 489 SLEF 492
F
Sbjct: 16801 KPSF 16804
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/321 (21%), Positives = 109/321 (33%), Gaps = 47/321 (14%)
Query: 405 APKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460
APK++ V V G + +V P T+ W +DG+ L + IKI
Sbjct: 21458 APKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKI--ADF 21515
Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQ 518
++ L + D G Y TA N G F + D P P + E S +
Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLS 21575
Query: 519 FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAA 578
+ P GG I Y + R W + + + ++ + L Y R+ A
Sbjct: 21576 WFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLK----VTKLLKGNEYIFRVMA 21631
Query: 579 LNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPS 638
+N G+GE + + PP P T + W G P
Sbjct: 21632 VNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCW------------GHPD 21679
Query: 639 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSD-HVMLK 697
+ DGGS I +Y+V R + + + + +D +
Sbjct: 21680 S----------------------DGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVS 21717
Query: 698 SLDWNAEYEVYVVAENQQGKS 718
L EYE ++AEN G S
Sbjct: 21718 GLTEGHEYEFRIMAENAAGIS 21738
Score = 48.9 bits (115), Expect = 2e-05
Identities = 63/291 (21%), Positives = 113/291 (38%), Gaps = 33/291 (11%)
Query: 405 APKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY 463
AP P+ +V EG+ + +P +SWFRDGQ++ +S ++I + +
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSIDQVEPYS--STAQVQFD 520
L + ++ + G Y+ A N GQ S +LV+A+T + +++ + +QV+
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
P++K+ + G E+ S + + + I PE + + A N
Sbjct: 125 VRVTGIPTPVVKFYRD----GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 581 GKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTT---------WPLPALATTE 631
+G ++ +E Q P + + + +S T + ++AT E
Sbjct: 181 --SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVE 238
Query: 632 -----------PAKGEPSAPKLEGQMGEDGNSI--KVNLIKQDDGGSPIRH 669
P K P P SI K L +Q SPIRH
Sbjct: 239 MVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQ-QSPSPIRH 288
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/305 (22%), Positives = 119/305 (39%), Gaps = 54/305 (17%)
Query: 419 GNQVNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--DFG 475
G + + + P+ + W + DG++ ++ ++S+ + D+ N D G
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID-------VTSSFTSLVLDNVNRYDSG 23009
Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
Y T N G +S + DTPS P ++ E + + ++ P GG I Y
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 23069
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E R + + + + + S + I L+ +Y R+ A N G+G + A +
Sbjct: 23070 VEKREATRKSYAAVVTNCHKNSWK----IDQLQEGCSYYFRVTAENEYGIG-LPAQTADP 23124
Query: 595 TQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIK 654
+ P PP ++ D T +L+ T+P
Sbjct: 23125 IKVAEVPQPPGK--------ITVDDVTRNSVSLSWTKP---------------------- 23154
Query: 655 VNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 713
+ DGGS I Y+V +A SE W R+ S ++ +L EY VVA N
Sbjct: 23155 -----EHDGGSKIIQYIVEMQAKHSEKWSECARVK--SLQAVITNLTQGEEYLFRVVAVN 23207
Query: 714 QQGKS 718
++G+S
Sbjct: 23208 EKGRS 23212
Score = 47.8 bits (112), Expect = 4e-05
Identities = 75/343 (21%), Positives = 138/343 (40%), Gaps = 32/343 (9%)
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
E+ + D L ++ V+ +E I+EN + KP I + +
Sbjct: 14347 EEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPD-------CKPTIDLETHDIIVI 14399
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
E++++ P+P+++W + + + ++ + + +H V KS++ DA
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP----KSVR-ADA 14454
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT--ISW 438
G Y T N +G + S+ ++V P + + +T E + T + +
Sbjct: 14455 GIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHY 14514
Query: 439 FRDGQLLPSSNYSNIKI-YNTPSASYLEVTPDSENDFGNYNCTAVNRI-GQESLEF---- 492
+ + Y + N S + ++ P+ E F AVN++ G E +E
Sbjct: 14515 VLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFF---RVKAVNKVGGGEYIELKNPV 14571
Query: 493 ILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549
I P P +D VE ++ TA+ + + P GG I+ Y E A GEE +W
Sbjct: 14572 IAQDPKQPPDPPVD-VEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEE----RW 14626
Query: 550 YDAKEASMEGIV-TIVGLKPETTYAVRLAALNGKGLGEISAAS 591
E + + T GL+ Y R+ A N G+ E S A+
Sbjct: 14627 KRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRAT 14669
Score = 47.8 bits (112), Expect = 4e-05
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G I AR E++ I + TI +V+A G+S + D G P PT+ W K
Sbjct: 22530 GAITARDEVDPPRISMDPKYKDTI-----VVHA----GESFKVDADIYGKPIPTIQWIKG 22580
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+++ E +D ++ L++K + D YI A+N AGE+ T+++KV +P
Sbjct: 22581 DQELSNTARLE-IKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 47.8 bits (112), Expect = 4e-05
Identities = 83/397 (20%), Positives = 147/397 (37%), Gaps = 47/397 (11%)
Query: 256 QEEDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATI-HLKVFAK----- 307
Q + EK+ +S + + E ++ A N+ G+ D + + V AK
Sbjct: 24252 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQ 24311
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P + N +++ E + + G P P+I+W + + + V A
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTR-----VNVEETATS 24366
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPV---------AVYTW 417
+ L +K D G+Y TA+N+ G ++++ + V P GPV V +W
Sbjct: 24367 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISW 24426
Query: 418 EGNQVNITCEVFAY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN 472
E C++ Y + T +W + + IKI + + + +EN
Sbjct: 24427 EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTT---IKITKLKTGTEYQFRIFAEN 24483
Query: 473 DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
+G +A +++ + P +P + + VQ+ EP GG I+
Sbjct: 24484 RYGK---SAPLDSKAVIVQYPFKEPGPPGTPFVTSIS--KDQMLVQWHEPVNDGGTKIIG 24538
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E + +W K + GL Y +++A N G+G+ S SE
Sbjct: 24539 YHLEQKEKNSILWVKL---NKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSE 24595
Query: 593 -FKTQPVHSPP--PPASASSSTPVPLSPPDTTWPLPA 626
F + PP P A + V L W PA
Sbjct: 24596 CFVARDPCDPPGRPEAIVITRNNVTLK-----WKKPA 24627
Score = 47.8 bits (112), Expect = 4e-05
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
T G S+ L+ G P P ++W+K G + + ++ S L + KV++ D
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT---TESYSLLIVDKVNRYDAG 29513
Query: 284 EYICIAENKAGEQDATIHLKVFAKP 308
+Y AEN++G++ AT+ +KV+ P
Sbjct: 29514 KYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 47.4 bits (111), Expect = 5e-05
Identities = 125/611 (20%), Positives = 211/611 (34%), Gaps = 104/611 (17%)
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV 206
P ++W D+ + V S L I + D G Y + + ++ + +
Sbjct: 26216 PNVLWSKPDTDLRTRAYVD-TTDSRTSLTIENANRNDSGKYT----LTIQNVLSAASLTL 26270
Query: 207 IVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+V V PPT Q++ +A L V PE IE+ E +
Sbjct: 26271 VVKVLDTPGPPTNITVQDVTKESAVLSWDV---------PENDGGAPVKNYHIEKREASK 26321
Query: 262 KYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
K S ++ ++L+ K + + A Y +GE + + + K + E +
Sbjct: 26322 KAWVSVTNNCNRLSYKVTNLQEGAIYYF---RVSGENEFGVGIPAETKEGVKITEKPSP- 26377
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-----VSSLTLKS 374
E++ +T S D + S+TW + S H VV + + V KS
Sbjct: 26378 --PEKLGVT-SISKDSV-SLTWLKPEHDGGSRIV----HYVVEALEKGQKNWVKCAVAKS 26429
Query: 375 IQYTDAG-----EYICT--ASNTIG-QDSQSMYLEVQYAPKLQGPV---------AVYTW 417
+ +G EY A N G D + + L V +L+ P VY
Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVR 26489
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G+ + + + P ++ RDG L ++ N +I T + + D G Y
Sbjct: 26490 AGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI--TAENLTINLKESVTADAGRY 26547
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKY 533
TA N G +V D P P+ I + S T ++++ P+ GG + Y
Sbjct: 26548 EITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVT--LKWEPPKYDGGSQVTNY 26605
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASE 592
R V W + ++ ++ L Y R+ A N G+ + I +A
Sbjct: 26606 ILLKRETSTAV----WTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACV 26661
Query: 593 FKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNS 652
P +P PP S T V W P
Sbjct: 26662 TVKLPYTTPGPP-STPWVTNVTRESITVGWHEPV-------------------------- 26694
Query: 653 IKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 711
+GGS + Y + + +S W+ +L + H + ++ YE V A
Sbjct: 26695 --------SNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYA 26746
Query: 712 ENQQGKSKAAH 722
EN G K +H
Sbjct: 26747 ENAAGVGKPSH 26757
Score = 47.4 bits (111), Expect = 5e-05
Identities = 108/538 (20%), Positives = 193/538 (35%), Gaps = 83/538 (15%)
Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL---SNNYLQIRGIKKTDEGT 186
+ GED ++ PPT+ W+ ++ L D R+ + S++ L I + + D G
Sbjct: 27284 KAGEDVQVLIPFKGRPPPTVTWRKDEKN--LGSDARYSIENTDSSSLLTIPQVTRNDTGK 27341
Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPT 244
Y + G K V V V T A Q + + G +VTL+ D P
Sbjct: 27342 YILT---IENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRG-TVTLLWDPPLIDGGSPI 27397
Query: 245 MSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQDATI 300
+++ IE+ + ++ + S S + K +D +++ + +AEN+ G
Sbjct: 27398 INYV-----IEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIG------ 27446
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN---ISSEEKTLDG 357
+P T E A E+ PI ++ + ST+ +S + DG
Sbjct: 27447 ----IGEPCET-TEPVKAAEVPA-----------PIRDLSMKDSTKTSVILSWTKPDFDG 27490
Query: 358 HMVVR--------------SHARVSS---LTLKSIQYTDAGEYICTASN--------TIG 392
V+ SHA +S + + ++ E+ A N TIG
Sbjct: 27491 GSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIG 27550
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
+ + P A T G+ V++ P +ISW +DG L S +
Sbjct: 27551 PITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEF- 27609
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQ 507
++ T + L + + G Y N + + ++ ++ PS P D+
Sbjct: 27610 -VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDE 27668
Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567
++ + + + +D PE GG I Y E R + W + + + L
Sbjct: 27669 IK--ADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFK----VPNLV 27722
Query: 568 PETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLP 625
+ Y R+ A N G+ + +S + P P V TW P
Sbjct: 27723 KDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAP 27780
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 4/193 (2%)
Query: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK-DVRFIVLSNNYLQIRG 178
FK R +A +VC V P + W +G+++I R Y Q+
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 179 IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN---ATANLGQSVTLVC 235
TD+ + R +G + V VP I + + A G+ V++
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049
Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
G P+P ++W K + I+ + + +S + V++ D Y+ A+N+ G
Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI 31109
Query: 296 QDATIHLKVFAKP 308
T+ L V P
Sbjct: 31110 DQKTVELDVADVP 31122
Score = 47.0 bits (110), Expect = 7e-05
Identities = 65/307 (21%), Positives = 112/307 (36%), Gaps = 47/307 (15%)
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
E + + + P+ ++SW + P + + + + ++ + L V ++D G Y
Sbjct: 19996 ENSNFRLKIPIKGKPAPSVSWKKGED--PLATDTRVSVESSAVNTTLIVYDCQKSDAGKY 20053
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKY 533
T N G + + P P+ D+V + T +++ P+ GG I Y
Sbjct: 20054 TITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMT--LKWAPPKDDGGSEITNY 20111
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
E R + ++KW A + + L Y R++A N G+GE
Sbjct: 20112 ILEKR----DSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-----GL 20162
Query: 594 KTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSI 653
K++P+ + P P P + D +L T+P K
Sbjct: 20163 KSEPIVARHP--FDVPDAPPPPNIVDVRHDSVSLTWTDPKK------------------- 20201
Query: 654 KVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAE 712
GGSPI Y + ++ +S WK + P + L EYE V+A
Sbjct: 20202 --------TGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 20253
Query: 713 NQQGKSK 719
N G K
Sbjct: 20254 NLAGVGK 20260
Score = 47.0 bits (110), Expect = 7e-05
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
I R ++ I+V V T+ I+ A G++ L D G P PTM W+KDG+
Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTV-----ILKA----GEAFRLEADVSGRPPPTMEWSKDGK 21500
Query: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
++E E I +D S+ L K + D Y A N G ++KV +P
Sbjct: 21501 ELEGTAKLEIKI-ADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555
Score = 46.2 bits (108), Expect = 1e-04
Identities = 95/398 (23%), Positives = 149/398 (37%), Gaps = 59/398 (14%)
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
A G ++ + G P+PT++W K G+QI ++ + + S+ L I + ++D
Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTW-KKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Y A N GE I ++V P ++ +E + S DP P
Sbjct: 21136 YPLTARNIVGEVGDVITIQVHDIPG----PPTGPIKFDEVSSDFVTFSWDP-PENDGGVP 21190
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTASNT--IGQDSQSMYL 400
N E + D V V T K+ + T EY A N +G S +
Sbjct: 21191 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 21250
Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNY------S 451
Y K+ GP QV + S TISW DG P Y
Sbjct: 21251 VANYPFKVPGPPGT-----PQVTAVTK----DSMTISWHEPLSDGG-SPILGYHVERKER 21300
Query: 452 NIKIYNTPSASYL--EVTPDSENDFG---NYNCTAVNRIGQESLEFILVQADTPSSP--S 504
N ++ T S + + + S G + A N G+ + PS P +
Sbjct: 21301 NGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKS-------KPSKPSEPMLA 21353
Query: 505 IDQVEPYSS---------TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+D ++P T +++ +PE TGG I Y E R ++ + +W A +
Sbjct: 21354 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKR----DLPNGRWLKANFS 21409
Query: 556 S-MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
+ +E T+ GL + Y R+ A N G IS SE
Sbjct: 21410 NILENEFTVSGLTEDAAYEFRVIAKN--AAGAISPPSE 21445
Score = 46.2 bits (108), Expect = 1e-04
Identities = 64/315 (20%), Positives = 106/315 (33%), Gaps = 46/315 (14%)
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465
PK + + V+ G + ++ P + W +DG+ L + + ++I +T + L
Sbjct: 24711 PKYKDVIVVHA--GETFVLEADIRGKPIPDVVWSKDGKELEETA-ARMEIKSTIQKTTLV 24767
Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEP 522
V D G Y N G +S+ + D P P ++ TA+ + ++ P
Sbjct: 24768 VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPE-GPLKVTGVTAEKCYLAWNPP 24826
Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582
GG I Y E R W + + + + + L P Y R+ A+N
Sbjct: 24827 LQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYK----VTKLLPGNEYIFRVMAVNKY 24882
Query: 583 GLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKL 642
G+GE + + PP P S + + TW P
Sbjct: 24883 GIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPV---------------- 24926
Query: 643 EGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDW 701
DDGG+ I Y++ R W + + + L
Sbjct: 24927 ------------------DDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTE 24968
Query: 702 NAEYEVYVVAENQQG 716
YE V AEN G
Sbjct: 24969 GHSYEFRVAAENAAG 24983
Score = 45.8 bits (107), Expect = 1e-04
Identities = 117/581 (20%), Positives = 200/581 (34%), Gaps = 122/581 (20%)
Query: 253 QIEQEEDDEKYIFSDDS----SQLTIKKVDKNDEAEYICIAENKAG-EQDATIHLKVFAK 307
+I E+DE I + + + TI + +N E + A N G + A + A+
Sbjct: 21793 EIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAE 21852
Query: 308 PKITYVENQTAMELEEQVTLTC--------EASGDPIPSITWRTSTRNISSEEKTLDGHM 359
++ E + +L + VT+ G P P + W ++LD
Sbjct: 21853 DRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD------HGESLD-KA 21905
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419
+ S + + L + ++ D+G+YI T N+ G S + + V P G
Sbjct: 21906 SIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP------------G 21953
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY-----NTPSASYLEVTPDSEN-- 472
++ + S T++W D LL S IK Y + +Y V +
Sbjct: 21954 PPQDLKVKEVTKTSVTLTW--DPPLLDGG--SKIKNYIVEKRESTRKAYSTVATNCHKTS 22009
Query: 473 ---DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ----------VEPYSSTAQVQF 519
D C+ R+ E+ I + A+T S + ++ ++ + +
Sbjct: 22010 WKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSW 22069
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
++PE GG IL Y E + G + KW + TI GL Y+ R++A
Sbjct: 22070 EKPEHDGGSRILGYIVEMQTKGSD----KWATCATVKVTE-ATITGLIQGEEYSFRVSAQ 22124
Query: 580 NGKGLGE---------------------------ISAASEFKTQ-PVHSPPPPASASSST 611
N KG+ + + A + K P P PA
Sbjct: 22125 NEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKD 22184
Query: 612 PVPLSP-----PDTTWPLPALATTEPAKGEPS--APKLEGQMGEDGNSIKVNL------- 657
VPL ++T L + + + KL GE ++ V +
Sbjct: 22185 NVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPP 22244
Query: 658 ---IKQD----------------DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKS 698
+K D DGGS I +Y+V R S+ + +
Sbjct: 22245 TGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 22304
Query: 699 LDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPATLG 739
L EY+ + AEN+ GKS + + P +P G
Sbjct: 22305 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPG 22345
Score = 45.4 bits (106), Expect = 2e-04
Identities = 75/365 (20%), Positives = 140/365 (38%), Gaps = 51/365 (13%)
Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
+ + P+++ + N A + + + +G P+ T++W KDG+ + +E S
Sbjct: 25391 IEIKPSVELPFHTFNVKAR--EQLKIDVPFKGRPQATVNWRKDGQTL-KETTRVNVSSSK 25447
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
+ L+IK+ K D Y N AG I + V +P + ++E
Sbjct: 25448 TVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRP-----GPPGPIRIDEVSCD 25502
Query: 328 TCEASGDPIPSITWRTSTRNISSEEK---TLDGHMVVRSHARVSSLTLKSIQYTDAGEY- 383
+ S +P P N E+K + H+V ++ AR S +K ++ T EY
Sbjct: 25503 SITISWNP-PEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTS---IKIVRLTTGSEYQ 25558
Query: 384 --ICTASNTIGQD--SQSMYLEVQYAPKLQGP------------VAVYTWEGNQVNITCE 427
+C A N G+ S+S + +Y GP + TW+ +
Sbjct: 25559 FRVC-AENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSR 25617
Query: 428 VFAY-----PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
V Y ++I W + ++L + + +K+ E +EN G C+
Sbjct: 25618 VIGYHLEYKERSSILWSKANKILIAD--TQMKVSGLDEGLMYEYRVYAENIAGIGKCS-- 25673
Query: 483 NRIGQESLEFILVQ--ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
+S E + + D P P + + + +++ +P GG I Y E R +
Sbjct: 25674 -----KSCEPVPARDPCDPPGQPEVTNIT--RKSVSLKWSKPHYDGGAKITGYIVERREL 25726
Query: 541 GEEVW 545
+ W
Sbjct: 25727 PDGRW 25731
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 18/135 (13%)
Query: 176 IRGIKKTDEGTYRCE--GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
I G K D CE G I A + ++ + N T ++V A G S+ L
Sbjct: 28331 INGAGKGDS----CEVTGTIKAVDRLTAPELDIDANFKQT-----HVVRA----GASIRL 28377
Query: 234 VCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
+G P PT W+K + D +D S LT++ ++ND +Y EN +
Sbjct: 28378 FIAYQGRPTPTAVWSKPDSNLSLRADIHT---TDSFSTLTVENCNRNDAGKYTLTVENNS 28434
Query: 294 GEQDATIHLKVFAKP 308
G + T +KV P
Sbjct: 28435 GSKSITFTVKVLDTP 28449
Score = 45.1 bits (105), Expect = 3e-04
Identities = 87/395 (22%), Positives = 149/395 (37%), Gaps = 39/395 (9%)
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
+PP + N A G+ + + G P P ++W KD ++Q ++++
Sbjct: 22146 IPPAFKLLFNTFTVLA--GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAES-TENN 22202
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
S LTIK + D Y+ N AGE T+++ V KP ++++E +
Sbjct: 22203 SLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG----PPTGPVKMDEVTADSI 22258
Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTA 387
S P P +S N E++ A V+ T+K+ + EY A
Sbjct: 22259 TLSWGP-PKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 22317
Query: 388 SNTIGQDS--QSMYLEVQYAPKLQGP-----VAVYTWEGNQVNITCEVFAYPSATISWFR 440
N G+ + S QY K+ GP V + + + +V + S I +
Sbjct: 22318 ENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHL 22377
Query: 441 DGQLLPSSNYSNIKIYNTP------SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ + S + +K+ TP + LE + E N + + + S ++
Sbjct: 22378 ERKERNSILW--VKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVA 22435
Query: 495 VQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D P P V S T +Q+ +P GG I Y E + + E W
Sbjct: 22436 RDPCDPPGRPEAIIVTRNSVT--LQWKKPTYDGGSKITGYIVEKKELPEGRW-------M 22486
Query: 554 EASMEGIV----TIVGLKPETTYAVRLAALNGKGL 584
+AS I+ + GL + Y R+ A N G+
Sbjct: 22487 KASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGV 22521
Score = 43.9 bits (102), Expect = 6e-04
Identities = 107/501 (21%), Positives = 171/501 (34%), Gaps = 63/501 (12%)
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
+T++ + G+P PT +W G+++ + D K ++L I +++D+ Y E
Sbjct: 13412 ITILVPSTGYPRPTATWC-FGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLE 13470
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP--IPSITWRTSTRNI 348
N+ I + V A+P E + ++ V LT E D P + R +
Sbjct: 13471 NRVKTISGEIDVNVIARPSAP-KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREV 13529
Query: 349 SSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY---LEVQYA 405
S + T V V L +Q + +C A N G + + +
Sbjct: 13530 SRKTWTKVMDFVTDLEFTVPDL----VQGKEYLFKVC-ARNKCGPGEPAYVDEPVNMSTP 13584
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL---PSSNYSNIKIYNTPSAS 462
+ P W N + P G ++ P + + + +
Sbjct: 13585 ATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAET 13644
Query: 463 YLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQA-DTPSSPSI----DQVEPYSSTA 515
+EVT E + Y A+NR G + S +QA DT +P I + + A
Sbjct: 13645 KMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKA 13704
Query: 516 QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVR 575
+ + P G P + K W + K + + VTIV K T
Sbjct: 13705 GTKIELPATVTGKP--EPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI 13762
Query: 576 LAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKG 635
+ A+N G A + + + P PPA A T V TW P
Sbjct: 13763 IEAVNVCG----RATAVVEVNVLDKPGPPA-AFDITDVTNESCLLTWNPP---------- 13807
Query: 636 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM 695
+DDGGS I +Y+V RA SE ++ +
Sbjct: 13808 ------------------------RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFK 13843
Query: 696 LKSLDWNAEYEVYVVAENQQG 716
L N EY V AEN G
Sbjct: 13844 ATKLIPNKEYIFRVAAENMYG 13864
Score = 43.9 bits (102), Expect = 6e-04
Identities = 134/644 (20%), Positives = 220/644 (34%), Gaps = 130/644 (20%)
Query: 162 KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV 221
K +F V + N + + + + EG Y + ++L PP I + I
Sbjct: 18867 KKYKFRVAARNAVGV-SLPREAEGVYEAKEQLL----------------PPKILMPEQI- 18908
Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281
T G+ + + G P PT W K +++ + +D SS L IK V + D
Sbjct: 18909 --TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHK-ADSSSILIIKDVTRKD 18965
Query: 282 EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW 341
Y AEN +G I + V P Q ++ + C S IP
Sbjct: 18966 SGYYSLTAENSSGTDTQKIKVVVMDAPG----PPQPPFDISDIDADACSLSWH-IPLEDG 19020
Query: 342 RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMY 399
++ N E+ + V + A V+ + + + EYI A N G
Sbjct: 19021 GSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFG------I 19074
Query: 400 LEVQYAPKL--QGPVAVYTWEGN----QVNITCEVFAYP-------SATISWF-----RD 441
E +PK+ Q P V + N +VN C A+ S I + R+
Sbjct: 19075 SEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 19134
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ- 496
L +N + ++ P A +E E F Y A+N+ G + E++ +
Sbjct: 19135 SLLWVKANDTLVRSTEYPCAGLVE---GLEYSFRIY---ALNKAGSSPPSKPTEYVTARM 19188
Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
D P P + ++ ST + + P+ GG I+ Y E + + W + A
Sbjct: 19189 PVDPPGKPEV--IDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKW-VRCNTAPHQ 19245
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASAS------- 608
+ T GL+ + Y R A + S S+ T + PP S
Sbjct: 19246 IPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLL 19305
Query: 609 ---SSTPVPLSPPDTTWPLPALA------------------------------------- 628
+ T V L P+P ++
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGD 19365
Query: 629 ---TTEPAKGEPSAPKLEGQMGEDG--NSIKVNLIKQD-----------DGGSPIRHYLV 672
T E + G SA + + G S+K+N + D DGGS I +Y+V
Sbjct: 19366 YTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIV 19425
Query: 673 RYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
R S ++ ++ L EY+ + AEN+ G
Sbjct: 19426 DKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYG 19469
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTIKKVDKNDEAEY 285
G+ +++ P PT+SW KDG++++ ++ +D S+ L + K + D Y
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEVKA---SDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 286 ICIAENKAGEQDATIHLKVFAKP 308
ENK G A+I++KV P
Sbjct: 14458 TITLENKLGSATASINVKVIGLP 14480
Score = 42.7 bits (99), Expect = 0.001
Identities = 71/336 (21%), Positives = 115/336 (34%), Gaps = 88/336 (26%)
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
N ++ + + ++ +EN+ G +G S ++ + P+SP ++ +
Sbjct: 14242 NFRVTDVIEGTEVQFQVRAENEAG---------VGHPSEPTEILSIEDPTSPPSPPLDLH 14292
Query: 512 SSTA-----QVQFDEPEATGGVPILKYKAEWRAVGEEVW----HSKWYDAKEASMEGIVT 562
+ A + + PE GG PI+ Y E VG E W D K EG+V
Sbjct: 14293 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVV- 14351
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTW 622
P+ Y +R+ A+N G+ E S SE P + + + +
Sbjct: 14352 -----PDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSI 14406
Query: 623 PLPALATTEPA-----------------------KGEPSAPK------------LEGQMG 647
P+P A P PK LE ++G
Sbjct: 14407 PVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLG 14466
Query: 648 EDGNSIKVNLI-------------------------KQDDGGSPIRHYLVRYRALSSEWK 682
SI V +I + DGG+PI HY++ R +
Sbjct: 14467 SATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGR--R 14524
Query: 683 PEIRLPSGSDHV--MLKSLDWNAEYEVYVVAENQQG 716
I + SG + + +K L N EY V A N+ G
Sbjct: 14525 TYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVG 14560
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/209 (23%), Positives = 89/209 (42%), Gaps = 14/209 (6%)
Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
+ + P+++ N + A G+ + + G P P +SW KDGE ++Q +
Sbjct: 24308 LTIQPSLKLPFNTYSIQA--GEDLKIEIPVIGRPRPNISWVKDGEPLKQ-TTRVNVEETA 24364
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S+ L IK+ +K+D +Y A N AG + + V KP + + V +
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424
Query: 328 TCEASGDPIPSITWRTSTRNISSEEK---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ E P+ T N E++ T HMV + AR +++ + ++ ++
Sbjct: 24425 SWEP-----PAYTGGCQISNYIVEKRDTTTTTWHMVSATVAR-TTIKITKLKTGTEYQFR 24478
Query: 385 CTASNTIGQDS--QSMYLEVQYAPKLQGP 411
A N G+ + S + VQY K GP
Sbjct: 24479 IFAENRYGKSAPLDSKAVIVQYPFKEPGP 24507
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GEI DIQ V I A+ +V G + + +G P P SW DG+ +
Sbjct: 15797 GEIPATDIQEEPEVFIDIGAQDCLV---CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKA 15853
Query: 257 EED-------DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+D D + +++SS + I + ++ +Y A+NKAG++ A +KV P
Sbjct: 15854 MKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/343 (21%), Positives = 133/343 (38%), Gaps = 52/343 (15%)
Query: 288 IAENKAGEQD-ATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIPS 338
+A N AGE D A + V K ++ E + +++ + + L+ G P P
Sbjct: 17190 LAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPK 17249
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
+TW+ R+ ++ + +D V S L +++ + D G Y T N G + S+
Sbjct: 17250 VTWKKEDRDAPTKAR-IDVTPVG------SKLEIRNAAHEDGGIYSLTVENPAGSKTVSV 17302
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNYSNIKI 455
+ V P G ++ S ++W DG + ++ +
Sbjct: 17303 KVLVLDKP------------GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD 17350
Query: 456 YNTPSASYLEVTPDSENDF------GN---YNCTAVNRIGQ----ESLEFI--LVQADTP 500
+ S L T ++ F GN + A N+ G+ E+ + I L P
Sbjct: 17351 VASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPP 17410
Query: 501 SSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + V+ + + +++P+ GG PI Y E++ G + W ++E
Sbjct: 17411 GPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKF---KTVTNLEC 17467
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPP 602
+VT GL+ TY R+ A N GLG + Q PP
Sbjct: 17468 VVT--GLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPP 17508
Score = 42.0 bits (97), Expect = 0.002
Identities = 79/381 (20%), Positives = 137/381 (35%), Gaps = 61/381 (16%)
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE---- 314
D +I + + ++ + + +E + +A N AG V K + E
Sbjct: 21009 DQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLR 21068
Query: 315 ----NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
+ + + + G P P++TW+ + + ++ + + A + L
Sbjct: 21069 GIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQR-----VNFETTATSTIL 21123
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFA 430
+ +D+G Y TA N +G+ + ++V P GP I + +
Sbjct: 21124 NINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIP---GPPTG--------PIKFDEVS 21172
Query: 431 YPSATISWF---RDGQLLPSSNYSNIKIYNTPSASYLEV--------------TPDSEND 473
T SW DG + P SNY +++ T S +++E+ T E
Sbjct: 21173 SDFVTFSWDPPENDGGV-PISNYV-VEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQ 21230
Query: 474 FGNYNCTAVNRIGQ-ESLEFILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEAT 525
F A NR G + + A+ P +P + V S T + + EP +
Sbjct: 21231 F---RVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMT--ISWHEPLSD 21285
Query: 526 GGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG 585
GG PIL Y E + +W + +K I GL Y R+ A N G
Sbjct: 21286 GGSPILGYHVERKERNGILWQTV---SKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKS 21342
Query: 586 EISAASE--FKTQPVHSPPPP 604
+ S SE P+ P P
Sbjct: 21343 KPSKPSEPMLALDPIDPPGKP 21363
Score = 41.6 bits (96), Expect = 0.003
Identities = 54/250 (21%), Positives = 92/250 (36%), Gaps = 47/250 (18%)
Query: 476 NYNCTAVNRIGQ----ESLEFILVQADT--PSSPS-IDQVEPYSSTAQVQFDEPEATGGV 528
++ AVN+ G+ E + +L + PS P ++ + +TA +++ PE GG
Sbjct: 14054 SFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGS 14113
Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
PI Y E R V + W + K+ T+ L + Y R+AA N G + +
Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTK----CTVTPLTEGSLYVFRVAAENAIGQSDYT 14169
Query: 589 AASE-FKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMG 647
+ + + P P A + V D W EP K
Sbjct: 14170 EIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKW--------EPPK------------- 14208
Query: 648 EDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYE 706
+DGG PI+ Y++ + L + W + + + + E +
Sbjct: 14209 -------------NDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQ 14255
Query: 707 VYVVAENQQG 716
V AEN+ G
Sbjct: 14256 FQVRAENEAG 14265
Score = 41.6 bits (96), Expect = 0.003
Identities = 89/449 (19%), Positives = 165/449 (36%), Gaps = 66/449 (14%)
Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
+GE+ CQ+ G DI W+ E + + ++S +D + TLT+ +D G
Sbjct: 30546 LGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMS---SDGRTHTLTVMTEEQEDEG 30601
Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV--VSSLPPTII 150
+Y C+ T E G ++ + P +++ + + V + P +
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661
Query: 151 WKHKGRDVILKKDVRFIVLSNNY--LQIRGI-KKTDEGTYRCEGRILARGEINFKDIQVI 207
W H G+ ++ + I + +Y L ++ + +KT G Y+ + +
Sbjct: 30662 WFH-GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ----------------L 30704
Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW---TKDG---------EQIE 255
NV T+ A ++ + +V +A +SW DG E+ E
Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCE 30764
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQD------ATIHLKVFAK 307
+E E + S S T + V+ + A Y A+N G D I F K
Sbjct: 30765 AKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEK 30824
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSH 364
P TA+ + +C + P P+ RN E+K V
Sbjct: 30825 PGAPGKPTITAVTKD-----SCVVAWKP-PASDGGAKIRNYYLEKREKKQNKWISVTTEE 30878
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV--YTWEGNQV 422
R + ++K++ E+ N +G +S+ + PK P+ + E +
Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCEN-LGGESEWSEISEPITPKSDVPIQAPHFKEELRNL 30937
Query: 423 NI--------TCEVFAYPSATISWFRDGQ 443
N+ C+V +P + W+R G+
Sbjct: 30938 NVRYQSNATLVCKVTGHPKPIVKWYRQGK 30966
Score = 40.8 bits (94), Expect = 0.005
Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%)
Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
P V EG C V YP ++W+ +GQL+ S ++ YL++
Sbjct: 1847 PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHYLDIVDCK 1903
Query: 471 ENDFGNYNCTAVNRIG------------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518
D G TA N G +E +L +A P P EP +VQ
Sbjct: 1904 SYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEP-RPEFHVHEPGKLQFEVQ 1962
Query: 519 -FDEP-EATGGVPILKYKAEWRAVGEEV------WHSKWYDAKEASMEGIVTIVGLK 567
D P + T ++K K R E+V SK+ E +T V LK
Sbjct: 1963 KVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELK 2019
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 9/132 (6%)
Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQAD--TPSSPSIDQV-EPYSSTAQ 516
L+VT E + TAVN G E+ FI + TP PS +V + +
Sbjct: 29300 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 29359
Query: 517 VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRL 576
+ + +P GG I+ Y E + + W+ +A + E T+ LK Y+ R+
Sbjct: 29360 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE--FTVPDLKMGQKYSFRV 29417
Query: 577 AALNGKGLGEIS 588
AA+N KG+ E S
Sbjct: 29418 AAVNVKGMSEYS 29429
Score = 40.4 bits (93), Expect = 0.006
Identities = 134/643 (20%), Positives = 232/643 (36%), Gaps = 93/643 (14%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G+ + C++ K++D+ W +G+ + RI V LTI +A+ DAG
Sbjct: 11227 GQPLYLSCELN---KERDVVW-RKDGKIVVEKPGRI-VPGVIGLMRALTINDADDTDAGT 11281
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y V + E + V V + Q + A+ CD+ P I W
Sbjct: 11282 YTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKD-TPNIKW-F 11339
Query: 154 KGRDVILKK--DVRFIVLSNN--YLQIRGIKKTDEGTYRCE---GRILARGEINFKDIQV 206
KG D I + D I+ N YL+I+ D Y E R A+ + +++++
Sbjct: 11340 KGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVEL 11399
Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS 266
+ + + + A + ++ D G W GE + E I +
Sbjct: 11400 LKPIEDVTIYEKESASFDAEISEA-----DIPG------QWKLKGELLRPSPTCE--IKA 11446
Query: 267 DDSSQ-LTIKKVDKNDEAEYICIAEN---------KAGEQDATIHLKVFAKPKITYVENQ 316
+ + LT+ KV + E + A N K E D + LK +T E +
Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLK-----DVTVPERR 11501
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
A + LT EA ++ W I S +K + + + L + Q
Sbjct: 11502 QA---RFECVLTREA------NVIWSKGPDIIKSSDK-----FDIIADGKKHILVINDSQ 11547
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSAT 435
+ D G Y + G+ + + K P+ T EG CE+ ++
Sbjct: 11548 FDDEGVY---TAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMH 11603
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ WF++ L +S + I + LE+ + +D L+ ++
Sbjct: 11604 VVWFKNDAKLHTSR--TVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLK--VL 11659
Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDE----PEATGGVPILKYKAEWRAVGEEVWHSKWYD 551
+AD + V+ + TA V+ DE E + VP+ +W GEE+ S Y
Sbjct: 11660 EADPYFT-----VKLHDKTA-VEKDEITLKCEVSKDVPV-----KWFKDGEEIVPSPKYS 11708
Query: 552 AKEASMEGIVTI--VGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASS 609
K + I+ I LK + Y K + A +P++ ++
Sbjct: 11709 IKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETA 11768
Query: 610 STPVPLSPPDT--TWPLPALATTEPAKGEPSAPKLEGQMGEDG 650
+ LS PD W L KG+P + ++ EDG
Sbjct: 11769 HFEIELSEPDVHGQWKL---------KGQPLTASPDCEIIEDG 11802
Score = 40.4 bits (93), Expect = 0.006
Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 211 PPTIQARQNIVNATANL-GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD-- 267
PP ++ ++ + G+++ + G P PT WTK+ E E D ++ + +
Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKE----EGELDKDRVVIDNVG 15156
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
S+L IK + D Y+ A N G + A ++VF P
Sbjct: 15157 TKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197
Score = 40.0 bits (92), Expect = 0.008
Identities = 86/406 (21%), Positives = 157/406 (38%), Gaps = 75/406 (18%)
Query: 279 KNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLTCEAS----- 332
++ + ++ A NK G D + + K + K + E + +L + + L +
Sbjct: 19656 EDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYV 19715
Query: 333 ---GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 389
G P P ITW S N++ ++ + ++S + L +++ DAG+YI T N
Sbjct: 19716 PVKGRPPPKITW--SKPNVNLRDRI---GLDIKSTDFDTFLRCENVNKYDAGKYILTLEN 19770
Query: 390 TIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLP 446
+ G+ ++ ++V P G VN+T + + SA ++W DG P
Sbjct: 19771 SCGKKEYTIVVKVLDTP------------GPPVNVTVKEISKDSAYVTWEPPIIDGG-SP 19817
Query: 447 SSNY---------------------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
NY ++ ++ N +EN++G I
Sbjct: 19818 IINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYG---------I 19868
Query: 486 GQESLEFILVQADTPSSPSID-QVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEE 543
G V+A P +D +V S S+ + + +P + GG I+ Y ++ + EE
Sbjct: 19869 GDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF--LTEE 19926
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
+KW + S+ + L Y R++A N G G S + V +P
Sbjct: 19927 ---NKWQRVMK-SLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDL 19982
Query: 604 PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGED 649
L+ ++ + L P KG+P AP + + GED
Sbjct: 19983 DLKGLPDL-CYLAKENSNFRLKI-----PIKGKP-APSVSWKKGED 20021
Score = 40.0 bits (92), Expect = 0.008
Identities = 19/81 (23%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G S+ + +G P P ++WTKD ++ + E ++ + L I + ++ D +++
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIEN---TESFTLLIIPECNRYDTGKFVM 20847
Query: 288 IAENKAGEQDATIHLKVFAKP 308
EN AG++ ++++V P
Sbjct: 20848 TIENPAGKKSGFVNVRVLDTP 20868
Score = 40.0 bits (92), Expect = 0.008
Identities = 29/150 (19%), Positives = 65/150 (43%), Gaps = 8/150 (5%)
Query: 166 FIVLSNNYLQIRGIKKTDEGTYRCEGR----ILARGEINFKDIQVIVNVPPT---IQARQ 218
+ ++S+N+ + + + D +R + ++++G + + P + AR
Sbjct: 28993 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 29052
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ T G + L G PEP + WTK ++++ E ++ + IK D
Sbjct: 29053 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCE-KVSLQYTGKRATAVIKFCD 29111
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKP 308
++D +Y +N +G + ++ +KV P
Sbjct: 29112 RSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 39.3 bits (90), Expect = 0.014
Identities = 81/436 (18%), Positives = 157/436 (36%), Gaps = 66/436 (15%)
Query: 102 DGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK 161
+G+ + T + K QK P P EGE A C V P + W G+ +++
Sbjct: 1825 EGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ--LIR 1882
Query: 162 KDVRFIVLSN--NYLQIRGIKKTDEGTYRC-----EGRILARGEI------NFKDI---- 204
K RF V + +YL I K D G + EG I + ++ +F+ +
Sbjct: 1883 KSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRA 1942
Query: 205 -----QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE---Q 256
+ V+ P +Q V+ + ++ +V ++ E++ +
Sbjct: 1943 PEPRPEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFK 2002
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDE-------------AEYICIAENKAGEQDATIHLK 303
+E Y + + +L +K D++ E + + E KA ++ I +
Sbjct: 2003 RRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIP 2062
Query: 304 VFAKPKITYVENQTAMELEEQVT-----------LTCEASGDPIPSITWRTSTRNISSEE 352
F KI + A ++ E++ G P P W + I +
Sbjct: 2063 TFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSD 2122
Query: 353 KTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ------YAP 406
+ V L ++ + D+ + A N G+ S +L VQ +
Sbjct: 2123 RI----YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2178
Query: 407 KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 466
+LQ VA + CE + P + W++DG + + ++++ +L +
Sbjct: 2179 ELQDVVA--KEKDTMATFECET-SEPFVKVKWYKDGMEVHEGD--KYRMHSDRKVHFLSI 2233
Query: 467 TPDSENDFGNYNCTAV 482
+D +Y+C V
Sbjct: 2234 LTIDTSDAEDYSCVLV 2249
Score = 38.9 bits (89), Expect = 0.018
Identities = 45/217 (20%), Positives = 86/217 (39%), Gaps = 13/217 (5%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ +D++V+ + + ++ I G+ V LV G P P SW G ++ + E
Sbjct: 29727 VTVQDLRVLPTIDLSTMPQKTI---HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESE 29783
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+ ++LTI++ D EY +N G TI + + KP
Sbjct: 29784 RVTVETHT-KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG----PPTGP 29838
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
++++E + S +P P + E++ + V+ T K + T
Sbjct: 29839 IKIDEIDATSITISWEP-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLT 29897
Query: 379 DAGEYICTASNT----IGQDSQSMYLEVQYAPKLQGP 411
+ EY+ + T IG QS +E + + ++ GP
Sbjct: 29898 EGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 29934
Score = 38.5 bits (88), Expect = 0.023
Identities = 73/329 (22%), Positives = 119/329 (36%), Gaps = 59/329 (17%)
Query: 419 GNQVNITCEVFAYPSATISWFRD-GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G + I V P T W ++ G+L + + I N + S L + D G Y
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGEL----DKDRVVIDNVGTKSELIIKDALRKDHGRY 15174
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQV---QFDEPEATGGVPILKYK 534
TA N G + + D P P +D ++P + ++ + +PE GG I +
Sbjct: 15175 VITATNSCGSKFAAARVEVFDVPG-PVLD-LKPVVTNRKMCLLNWSDPEDDGGSEITGFI 15232
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E + W + + + + I GL Y R+ A N G G
Sbjct: 15233 IERKDAKMHTWRQP-IETERSKCD----ITGLLEGQEYKFRVIAKNKFGCG--------- 15278
Query: 595 TQPVHSPPPPASASSSTPV-PLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSI 653
PP V PL PP + L TE K + E
Sbjct: 15279 --------PPVEIGPILAVDPLGPPTSP---ERLTYTERTKSTITLDWKE---------- 15317
Query: 654 KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPS----GSDHVMLKSLDWNAEYEVYV 709
+ +GGSPI+ Y++ R KP+ + + ++++LD + YE V
Sbjct: 15318 -----PRSNGGSPIQGYIIEKRRHD---KPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 15369
Query: 710 VAENQQGKSKAAHFVFRTSAQPTAIPATL 738
A N+ G+S+ + Q +P T+
Sbjct: 15370 KAVNEIGESEPS-LPLNVVIQDDEVPPTI 15397
Score = 38.1 bits (87), Expect = 0.031
Identities = 47/204 (23%), Positives = 77/204 (37%), Gaps = 15/204 (7%)
Query: 117 KLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQI 176
K +F P + EG+ A VV P W H G+ ++ + ++ + +
Sbjct: 1456 KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSL 1515
Query: 177 RGIKKT--DEGTYRCEGRILARGEINFKDIQVIVNVPPT-IQARQNIVNATANL----GQ 229
+ T D G E ++A+ I VI+ V Q + V N+ G
Sbjct: 1516 IIVPATPSDSG----EWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571
Query: 230 SVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQLTIKKVDKNDEAEYICI 288
+ + A G P P + W K+ + I + + I + + L I D A Y
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631
Query: 289 AENKAGEQDATIHLKV---FAKPK 309
A NKAG + V FA+P+
Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPE 1655
Score = 38.1 bits (87), Expect = 0.031
Identities = 95/438 (21%), Positives = 176/438 (40%), Gaps = 47/438 (10%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ G F +V G D + W+ NG K+ RI W +D+ L I + +D
Sbjct: 2089 VGQGSDAHFRVRVVGKP-DPECEWYK-NGVKIE-RSDRIYWYWPEDNVCELVIRDVTAED 2145
Query: 91 AG--IYKCV-VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP- 146
+ + K + + GE S + V K Q + F +E +D + + +S P
Sbjct: 2146 SASIMVKAINIAGETSSHAFLLVQAK--QLITFTQELQDVVAKE-KDTMATFECETSEPF 2202
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
+ W G +V + ++ + S+ ++L I I +D Y C +L E
Sbjct: 2203 VKVKWYKDGMEV--HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSC---VLVEDENVKTT 2257
Query: 204 IQVIVN--VPPTIQARQNIVNATANLGQSVTLVC--DAEGFPEPTMSWTKDGEQIEQEED 259
++IV V ++ Q+I + G+ +V + EG W + +E + +
Sbjct: 2258 AKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEG------KWYHN--DVELKSN 2309
Query: 260 DEKYIFSDDSSQ-LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+ I S Q LT+K V K D+ EY + + K T LK+ +P I ++ +
Sbjct: 2310 GKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK----KTTCKLKMKPRP-IAILQGLSD 2364
Query: 319 MELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
++ E V L + S + + + W + + ++ H+V+ + + L ++ +
Sbjct: 2365 QKVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRV---HIVIDKQSHM--LLIEDMT 2418
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATI 436
DAG Y T +G S S + V + V EG + + C+V ++
Sbjct: 2419 KEDAGNYSFTIP-ALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSV 2476
Query: 437 SWF-RDGQLLPSSNYSNI 453
W+ D Q+ P I
Sbjct: 2477 KWYLNDEQIKPDDRVQAI 2494
Score = 37.7 bits (86), Expect = 0.040
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 238 EGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297
+G P P++SW K GE + S ++ L + K+D +Y +N AG ++
Sbjct: 20007 KGKPAPSVSWKK-GEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKE 20065
Query: 298 ATIHLKVFAKPKI 310
TI +KV KP I
Sbjct: 20066 GTISIKVVGKPGI 20078
Score = 37.0 bits (84), Expect = 0.068
Identities = 69/346 (19%), Positives = 126/346 (36%), Gaps = 64/346 (18%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA----MELEEQV 325
+Q + + ++ + A N AG + + P + VE + A ++ E +
Sbjct: 20731 TQFVVPDLQTKEKYNFRISAINDAGVGEPAVI------PDVEIVEREMAPDFELDAELRR 20784
Query: 326 TLTCEAS----------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
TL A G P P +TW N+ + + + + L +
Sbjct: 20785 TLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRAN-------IENTESFTLLIIPEC 20837
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
D G+++ T N G+ S + + V P GPV +N+ S T
Sbjct: 20838 NRYDTGKFVMTIENPAGKKSGFVNVRVLDTP---GPV---------LNLRPTDITKDSVT 20885
Query: 436 ISW--------FRDGQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVN 483
+ W R + + K Y+T + +VT SE + A N
Sbjct: 20886 LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAEN 20945
Query: 484 RIG----QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
G E+ E + ++ PS P S++ ++ ST + + +P+ GG I Y E +
Sbjct: 20946 EYGIGEPTETTEPVKA-SEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQ 21004
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIV-GLKPETTYAVRLAALNGKG 583
G + W +++G+ +V L Y ++ A+N G
Sbjct: 21005 RKGSDQW------THITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 21044
Score = 37.0 bits (84), Expect = 0.068
Identities = 36/187 (19%), Positives = 79/187 (42%), Gaps = 14/187 (7%)
Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSD 267
+PP I+ ++ T ++ L +G P P + W +D GE +++ + +
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES----TS 21911
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
+ L + V++ D +YI EN +G + A ++++V P ++++E
Sbjct: 21912 SYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP-----GPPQDLKVKEVTKT 21966
Query: 328 TCEASGDPIPSITWRTSTRN--ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
+ + DP P + + +N + E T + V ++ +S + +Q + +
Sbjct: 21967 SVTLTWDP-PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 22025
Query: 386 TASNTIG 392
A N G
Sbjct: 22026 LAENEYG 22032
Score = 36.6 bits (83), Expect = 0.089
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED-DEKYIFSDDSSQLTIKKVDKNDEAEYI 286
G ++ L +G P P ++W+K + D K +D + L + V+K D +YI
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKS--TDFDTFLRCENVNKYDAGKYI 19765
Query: 287 CIAENKAGEQDATIHLKVFAKP 308
EN G+++ TI +KV P
Sbjct: 19766 LTLENSCGKKEYTIVVKVLDTP 19787
Score = 36.6 bits (83), Expect = 0.089
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 5/82 (6%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS-SQLTIKKVDKNDEAEYI 286
G S T+ G P P + W+K + Y+ + DS + LTI+ ++ND +Y
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRA----YVDTTDSRTSLTIENANRNDSGKYT 26256
Query: 287 CIAENKAGEQDATIHLKVFAKP 308
+N T+ +KV P
Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTP 26278
Score = 36.2 bits (82), Expect = 0.12
Identities = 52/239 (21%), Positives = 86/239 (35%), Gaps = 26/239 (10%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN----YLQIRGIKKTDEGT 186
EG A + P + W G+ VI + + +S + L I + K + G
Sbjct: 19 EGSTATFEAHISGFPVPEVSWFRDGQ-VISTSTLPGVQISFSDGRAKLTIPAVTKANSGR 77
Query: 187 YRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
Y + G+ + E+ K PP Q + + T G V L G P
Sbjct: 78 YSLKATNGSGQATSTAELLVK----AETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
P + + +DG +I Q D + D L I + D Y A N G +T
Sbjct: 132 TPVVKFYRDGAEI-QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190
Query: 302 LKVFAKPKITYVENQTAM---ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG 357
L V + ++ + +T + ++ E E I R+I++ E +DG
Sbjct: 191 LLVQGEEEVPAKKTKTIVSTAQISESRQTRIE------KKIEAHFDARSIATVEMVIDG 243
Score = 36.2 bits (82), Expect = 0.12
Identities = 39/158 (24%), Positives = 62/158 (39%), Gaps = 33/158 (20%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAGE---------------QDATIHLKVFAKPKITYVEN 315
Q T+K++ + + + A N AGE + + L V K I +
Sbjct: 15060 QYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAG 15119
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKS 374
+T + + +G P+P+ W + EE LD VV + S L +K
Sbjct: 15120 KT-------LRIPAVVTGRPVPTKVW-------TKEEGELDKDRVVIDNVGTKSELIIKD 15165
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV 412
D G Y+ TA+N+ G + +EV P GPV
Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVP---GPV 15200
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%)
Query: 14 LGTAVSLQVDIVPSQGE-------ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ 66
L T+ L+++ P Q +S +S F C+V+ D D ++W+ E LT +Q
Sbjct: 8821 LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFD--DAIVTWYKGPTE-LTESQ 8877
Query: 67 QRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
+ ND +TI+N DD G+Y + E E+ +T + + K
Sbjct: 8878 KYN--FRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTK 8926
Score = 35.4 bits (80), Expect = 0.20
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 661 DDGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 717
DDGGS I +Y+V R S++W P H K L+ +Y V AENQ G+
Sbjct: 17335 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSH-FAKHLNEGNQYLFRVAAENQYGR 17391
Score = 34.7 bits (78), Expect = 0.34
Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 4/87 (4%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P +P + ++ S+ + +++P GG I Y E E+ W A +
Sbjct: 21759 PGNPRV--LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS- 21815
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGE 586
TI GL Y +R+ A+N +GLGE
Sbjct: 21816 -YTITGLTENQEYKIRIYAMNSEGLGE 21841
Score = 33.9 bits (76), Expect = 0.58
Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 6/93 (6%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
PS P I V+ +T + + +P GG PI Y E++ + W + +
Sbjct: 26087 PSKPKI--VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTE--- 26141
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
TI GL Y R+ ++N G + S +S+
Sbjct: 26142 -YTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173
Score = 33.9 bits (76), Expect = 0.58
Identities = 119/595 (20%), Positives = 204/595 (34%), Gaps = 92/595 (15%)
Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIF---- 115
EK + R S+ N DSSS LTI +D G Y + G +TV+VK+
Sbjct: 27309 EKNLGSDARYSIE-NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPA 27367
Query: 116 --QKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY 173
QKL K+ R + ++ P I + + RD K+ + +
Sbjct: 27368 ACQKLQVKHVS-----RGTVTLLWDPPLIDGGSPIINYVIEKRDA-TKRTWSVVSHKCSS 27421
Query: 174 LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
+ I +++ + R+LA EI + + I + + ++
Sbjct: 27422 TSFKLIDLSEKTPFFF--RVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSV 27479
Query: 234 VCDAEGFPEPTMSWTK---DGEQIEQE---------EDDEKYIFSDDSSQLTIKKVDKND 281
+ +SWTK DG + E E + + ++ + ++ +
Sbjct: 27480 I----------LSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQS 27529
Query: 282 EAEYICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASG 333
E+ A+N+ G D + K I E Q + + V L G
Sbjct: 27530 VLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKG 27589
Query: 334 DPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTL--KSIQYTDAGEYICTASNTI 391
P PSI+W + E VR + +TL K+ + G+Y N +
Sbjct: 27590 KPKPSISWLKDGLPLKESE-------FVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV 27642
Query: 392 GQDSQSMYLEVQYAP-KLQGPV---------AVYTWEGNQVN----ITCEVFAYPSATIS 437
+ + + + P K +GP+ + +W+ + N ITC ++ S
Sbjct: 27643 CRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITC--YSIEKRETS 27700
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ- 496
+ S + K+ N + + +EN +G + Q + I+V
Sbjct: 27701 QTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYG---------VSQPLVSSIIVAK 27751
Query: 497 -----ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 551
P P I V S + +D P GG + + E + +W K
Sbjct: 27752 HQFRIPGPPGKPVIYNVT--SDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILW-QKVNT 27808
Query: 552 AKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KTQPVHSPPPP 604
+ + E T GL Y R+ A N GL S S+F PV P P
Sbjct: 27809 SPISGREYRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTP 27861
Score = 33.5 bits (75), Expect = 0.76
Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 43/312 (13%)
Query: 40 LCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT 99
+C+V G K + W+ G+++ + + + L I + DDA +Y+ T
Sbjct: 30948 VCKVTGHPKPI-VKWYR-QGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRAT 31005
Query: 100 GEDGSES-----EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
+ GS S E V KI + R GE I P I W+ K
Sbjct: 31006 NQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALR-GEVVSIKIPFSGKPDPVITWQ-K 31063
Query: 155 GRDVILKKDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRILARGEINFKDIQV-IVNV 210
G+D+I ++++ ++ + G+++ D G Y + R I+ K +++ + +V
Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAK--NRFGIDQKTVELDVADV 31121
Query: 211 P------PTIQARQNIVNAT----ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
P ++ VN T A+ G S E W + G+ E
Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARE----- 31176
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
++ T+ + ++ IAENK G + ++P IT + AM
Sbjct: 31177 ---------TRYTVINLFGKTSYQFRVIAENKFGLSKPSEP----SEPTITKEDKTRAMN 31223
Query: 321 LEEQVTLTCEAS 332
+E+V T E S
Sbjct: 31224 YDEEVDETREVS 31235
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 144 bits (364), Expect = 2e-34
Identities = 179/771 (23%), Positives = 291/771 (37%), Gaps = 107/771 (13%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANI-- 88
+S GE C+ G + +I W+ N R++ V D + L + + +
Sbjct: 75 VSRGEPATLPCRAEGRPRP-NIEWYK--------NGARVATVREDPRAHRLLLPSGALFF 125
Query: 89 ----------DDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVI 137
D G+Y CV G+ + ++++ + F+ +P GE AV+
Sbjct: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185
Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
C P P++ W+ G LK++ I + L + K+D G Y C +A
Sbjct: 186 ECVPPRGHPEPSVSWRKDGAR--LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA- 242
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GE +V+V P+ R VN VT +C+ +G P P + W K+ +
Sbjct: 243 GERESAAAEVMVLERPSFLRRP--VNQVVLADAPVTFLCEVKGDPPPRLRWRKE----DG 296
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E +Y D S L I V DE Y C+AEN G +A+ L V P++
Sbjct: 297 ELPTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSHARVSSLTLK 373
E V CE G+P P+I W+ + S+ G V + L +
Sbjct: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ---LNIT 412
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
++Q DAG Y+C A + G LE++ A LQGP G+ V + C
Sbjct: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
V P ++ W +DGQ L + + T + L + E D G Y+C A + G
Sbjct: 473 RVTGNPQPSVRWKKDGQWLQGDDLQ----FKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
Query: 487 QESLEFIL-------VQADTPSSPSIDQVEP-------YSSTAQVQFDEPEATGGVPILK 532
+ + L V D P+ PS P + + +P G +
Sbjct: 529 EATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E + W + T+ GL+P T Y + A+ GL E S
Sbjct: 589 YVIE---AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPS---- 641
Query: 593 FKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPS----APKLEGQMGE 648
PV P +S S PV +P +G+ A +L+ +
Sbjct: 642 ----PVSEPVRTQDSSPSRPV----------------EDPWRGQQGLAEVAVRLQEPIVL 681
Query: 649 DGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE---WKP-EIRLPSGSDHVMLKSLDWNAE 704
+++V+ D ++ + V +R E W +++ PS +L+ L +
Sbjct: 682 GPRTLQVSW-TVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPS-QQSTVLRGLPPGTQ 739
Query: 705 YEVYVVAENQQGKSKAAHFVFRT------SAQPTAIPATLGGNSASYTFVS 749
++ V A+ Q+G + V R+ S P + LGG+ S VS
Sbjct: 740 IQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVS 790
Score = 46.6 bits (109), Expect = 9e-05
Identities = 62/278 (22%), Positives = 103/278 (37%), Gaps = 31/278 (11%)
Query: 306 AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
A P+I + E TL C A G P P+I W + +++ + H ++
Sbjct: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
Query: 366 RV--SSLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
+ + D G Y C A N +G + S+ + V Q P V G
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
Query: 421 QVNITC-EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
+ C +P ++SW +DG L I I L ++ ++D G Y C
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEE-GRITI----RGGKLMMSHTLKSDAGMYVC 236
Query: 480 TAVNRIGQE---SLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEP------EATG 526
A N G+ + E ++++ + ++QV P + +V+ D P + G
Sbjct: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG 296
Query: 527 GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV 564
+P +Y+ HS W A EG T V
Sbjct: 297 ELPTGRYEIRSD-------HSLWIGHVSAEDEGTYTCV 327
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 142 bits (359), Expect = 9e-34
Identities = 162/593 (27%), Positives = 243/593 (40%), Gaps = 80/593 (13%)
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLS 170
+K F L F + P+ G + ++ C S P I WK G + L D R LS
Sbjct: 34 IKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS 93
Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
N L I+ I K DEG Y+CE + G I + +V V P ++ V TA
Sbjct: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESV--TA 151
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
+G +V L C+ G P PT+ W K+ + + D + + S L I ++ D Y
Sbjct: 152 FMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLP-SGALQISRLQPGDIGIY 210
Query: 286 ICIAENKAGEQDAT-IHLKVFAKP----KITYVE---NQTAMELEEQVTLTCEASGDPIP 337
C A N A + +++ + P ++ +++ N A+E ++ V L C SG P P
Sbjct: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPP 269
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
S TW I K S S+L + ++ D+G Y C + S S
Sbjct: 270 SFTWLRGEEVIQLRSKKY-------SLLGGSNLLISNVTDDDSGMYTCVVTYKNENISAS 322
Query: 398 MYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456
L V P L P +Y +E + C V P T++W ++G ++ S+Y I
Sbjct: 323 AELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-- 380
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSIDQVEPYSST 514
S L + ++D G Y C A N G Q S + I+ + PSS + S+
Sbjct: 381 ---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLP-----SAP 432
Query: 515 AQVQFDEPEATGGVPILK----YKAEWRAVGEE--------VWHSKWYDAKEASMEGI-- 560
V VP+L + WR E V+ S+ D +E ++
Sbjct: 433 RDV----------VPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQP 482
Query: 561 ----VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPA---SASSSTPV 613
+T+ LKPE Y R+ A N G GE S + TQP P P A S++P
Sbjct: 483 GSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPT 542
Query: 614 PLSPPDTTWPLPALATTEPAKG------EPSAPKLEGQMGEDGNSIKVNLIKQ 660
+ TW PA A P +G E S K E + DG S K+ +K+
Sbjct: 543 SIL---ITWEPPAYA-NGPVQGYRLFCTEVSTGK-EQNIEVDGLSYKLEGLKK 590
Score = 99.0 bits (245), Expect = 1e-20
Identities = 84/324 (25%), Positives = 133/324 (41%), Gaps = 28/324 (8%)
Query: 90 DAGIYKCVVT-GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
D G+Y+C + G+ GS T V + L F + G+ ++ C+V+ PT
Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT 170
Query: 149 IIWKHKGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
I W+ +D+ + D R +VL + LQI ++ D G YRC R A + +V
Sbjct: 171 IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTG-NEAEVR 229
Query: 208 VNVPPTIQAR----QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+ P + + Q N A G+ L C G+P P+ +W + GE++ Q +
Sbjct: 230 ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS 288
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP-KITYVENQTAMELE 322
+ S L I V +D Y C+ K A+ L V P + + N A E
Sbjct: 289 LLG--GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYE-S 345
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYT 378
+ C SG P+P++ W +G +V+ S S+L + + +
Sbjct: 346 MDIEFECTVSGKPVPTVNWMK------------NGDVVIPSDYFQIVGGSNLRILGVVKS 393
Query: 379 DAGEYICTASNTIGQDSQSMYLEV 402
D G Y C A N G S L V
Sbjct: 394 DEGFYQCVAENEAGNAQTSAQLIV 417
Score = 64.7 bits (156), Expect = 3e-10
Identities = 153/702 (21%), Positives = 274/702 (39%), Gaps = 85/702 (12%)
Query: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
S L I N DD+G+Y CVVT ++ + S A+ + + F N P+ E D
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENIS-ASAELTVLVPPWFLNHPSNLYAYESMDIEFE 351
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
C V PT+ W G DV++ D F ++ + L+I G+ K+DEG Y+C +A E
Sbjct: 352 CTVSGKPVPTVNWMKNG-DVVIPSDY-FQIVGGSNLRILGVVKSDEGFYQC----VAENE 405
Query: 199 INFKDIQVIVNVP-PTIQARQNIVNATANL------GQSVTL----VCDAEGFPEP-TMS 246
+ VP P I + + +A ++ + V L +A+G + T+
Sbjct: 406 AGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 465
Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
++++G+ E+ + + S QLT+ + + +A N+ G +++ +KV
Sbjct: 466 FSREGDNRERALNTTQ----PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
Query: 307 KPKITY---VENQTAMELE-EQVTLTCE----ASGDPIPSITWRTSTRNISSEEKTLDG- 357
+P++ VEN A+ + +T E A+G + T + +DG
Sbjct: 522 QPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGL 581
Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW 417
+ + + +L+ + Y G + T T+ S +V AP P V
Sbjct: 582 SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLS-----DVPSAP----PQNVSLE 632
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLL---PSSNYSNIKIYNTPSASYLEVTPDSENDF 474
N +I PS T + F G + ++ ++ + YL + + +
Sbjct: 633 VVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQY 692
Query: 475 G-NYNCTAVNRIG-------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATG 526
+ VN G E+ E L ++ P PS V P ++ + + P
Sbjct: 693 SFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSW-TPPLNP 751
Query: 527 GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
+ + Y + VG + D+K+ +I L+ + Y + L A N G G
Sbjct: 752 NIVVRGYIIGY-GVGSPYAETVRVDSKQR----YYSIERLESSSHYVISLKAFNNAGEG- 805
Query: 587 ISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQ- 645
P ++ + S P P D L T+ P P P + Q
Sbjct: 806 -------------VPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQA 852
Query: 646 MGEDGNSIKV----NLIKQDDGGSPIRHYLVRYR---ALSSEWKPEIRLPSGSDHVMLKS 698
+ ++++V N + ++ S +R Y VR+R + S+++K E + S
Sbjct: 853 VALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE---DTTSLSYTATG 909
Query: 699 LDWNAEYEVYVVAENQQGKSKAAHFVFRTS--AQPTAIPATL 738
L N YE V+ + S + T+ A PT+ P L
Sbjct: 910 LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDL 951
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 140 bits (353), Expect = 4e-33
Identities = 181/782 (23%), Positives = 299/782 (38%), Gaps = 135/782 (17%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109
ISW NG+ L N + + + TLTI + N G Y+C+ G+ AT
Sbjct: 59 ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112
Query: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166
V+V + K+ T +E G I C V S P + ++K R L+ +
Sbjct: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168
Query: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221
++L + LQI + D+G+Y+C ++ + I +++V+ P +
Sbjct: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228
Query: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
A A L +S VTL C G P P + W KDG+ I + + S L VD
Sbjct: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283
Query: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339
D Y C+A NK+G+ + T + V I+ + L V TC+ G+P P+
Sbjct: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
Query: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY 399
TW + + I + H+ + ++S +T++ D G Y C A N IG +
Sbjct: 344 TWFHNAQPIHPSAR----HLTAGNGLKISGVTVE-----DVGMYQCVADNGIGFMHSTGR 394
Query: 400 LEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS------- 447
LE++ + P + PV+ +G+ V ++C P I W+ L+ S
Sbjct: 395 LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLR 454
Query: 448 --SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
S S + + + AS L + ++ G Y C A N G E
Sbjct: 455 SKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEAS 514
Query: 494 LV--------QADTPSSPSIDQVEPYSS-------------------------------- 513
L+ +A+T + P Q + S
Sbjct: 515 LMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGI 574
Query: 514 ---TAQVQFDEPEA--------------TGGVPILKYKAEWRAVGEEV-WHSKWYDAKEA 555
A + P+ GG+PI Y ++R + + V W+ +
Sbjct: 575 SVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVP 634
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPL 615
E + + L+P + Y V + A + G G+ A F+T + + +SS PV +
Sbjct: 635 GSENELHLAELEPSSLYEVLMVARSAAGEGQ-PAMLTFRTSKEKTASSKNTQASSPPVGI 693
Query: 616 SPPDTTWPLP------ALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH 669
L + G P AP S+ V I + +GGSPI
Sbjct: 694 PKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITA 753
Query: 670 YLVRYRAL-SSEWKPEIR-LPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRT 727
+ V Y+ + +S W +P V ++SL+ + Y+ V+A N G+S FR+
Sbjct: 754 FKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGES------FRS 807
Query: 728 SA 729
SA
Sbjct: 808 SA 809
Score = 40.4 bits (93), Expect = 0.006
Identities = 52/224 (23%), Positives = 89/224 (39%), Gaps = 34/224 (15%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P +P + S T+ P A GG PI +K E++ + W D + +
Sbjct: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPD 619
V + L+P +TY R+ A+N G S+AS Q V P + SS P+
Sbjct: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASR-PYQVVGFP----NRFSSRPI------ 827
Query: 620 TTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL-- 677
P +A TE + + +K I + +PI+ + + YR
Sbjct: 828 ---TGPHIAYTE-------------AVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDS 871
Query: 678 --SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 719
S++K ++ S H M+ L Y++ + N+ G+S+
Sbjct: 872 DNDSDYKRDVVEGSKQWH-MIGHLQPETSYDIKMQCFNEGGESE 914
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 140 bits (352), Expect = 6e-33
Identities = 112/384 (29%), Positives = 163/384 (42%), Gaps = 31/384 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P +++ G + +F C+ G+ K +I W N E R++++ DD TL I N
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKP-EIIWLRNNNELSMKTDSRLNLL--DDG--TLMIQN 306
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIF---QKLMFKNAPTPQEFREGEDAVIVCDVV 142
D GIY+C+ G V ++ F + F P E GE + C
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG--RILARGEIN 200
PP I W +G L D R + + L I+ + + D G Y C I +
Sbjct: 367 GHPPPRISWT-RGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
F +Q + T Q R I GQ+V C+A+G P P ++WTK G Q+ D
Sbjct: 426 FIIVQALPQFTVTPQDRVVIE------GQTVDFQCEAKGNPPPVIAWTKGGSQLSV---D 476
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTA 318
+++ S L I V +D+ +Y C A N G Q HL V + P + + T
Sbjct: 477 RRHLVLS-SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+E+ V L C + G+P P+ITW N + T G + LT+ +
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITW-----NKDGVQVTESGKFHISPEG---FLTINDVGPA 587
Query: 379 DAGEYICTASNTIGQDSQSMYLEV 402
DAG Y C A NTIG S SM L V
Sbjct: 588 DAGRYECVARNTIGSASVSMVLSV 611
Score = 139 bits (350), Expect = 1e-32
Identities = 108/378 (28%), Positives = 161/378 (42%), Gaps = 27/378 (7%)
Query: 124 PTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD 183
P + G C + P IIW ++ +K D R +L + L I+ ++TD
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
Query: 184 EGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV----NATANLGQSVTLVCDAEG 239
+G Y+C + +A GE+ +++ + P AR V N +G+SVTL C A G
Sbjct: 312 QGIYQCMAKNVA-GEVKTQEVTLRYFGSP---ARPTFVIQPQNTEVLVGESVTLECSATG 367
Query: 240 FPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDAT 299
P P +SWT+ G++ D I S L I+ V + D EY C A N AT
Sbjct: 368 HPPPRISWTR-GDRTPLPVDPRVNI--TPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
Query: 300 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359
+ V A P+ T + + V CEA G+P P I W +S + + H+
Sbjct: 425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR----HL 480
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ--YAPKLQGPVAVYTW 417
V+ S +L + + D G+Y C A N IG +L VQ P + T
Sbjct: 481 VLSS----GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536
Query: 418 E-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
E G V + C P I+W +DG + S K + +P +L + D G
Sbjct: 537 EVGANVQLPCSSQGEPEPAITWNKDGVQVTESG----KFHISPE-GFLTINDVGPADAGR 591
Query: 477 YNCTAVNRIGQESLEFIL 494
Y C A N IG S+ +L
Sbjct: 592 YECVARNTIGSASVSMVL 609
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/198 (28%), Positives = 82/198 (41%), Gaps = 18/198 (9%)
Query: 307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR 366
+P+IT + V TC A G+P P I W + +S + D + +
Sbjct: 245 RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMK---TDSRLNLLDD-- 299
Query: 367 VSSLTLKSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQYAPK----LQGPVAVYTWEGNQ 421
+L +++ Q TD G Y C A N G+ +Q + L +P + P G
Sbjct: 300 -GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES 358
Query: 422 VNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
V + C +P ISW R D LP NI TPS L + + D G Y C+
Sbjct: 359 VTLECSATGHPPPRISWTRGDRTPLPVDPRVNI----TPSGG-LYIQNVVQGDSGEYACS 413
Query: 481 AVNRIGQ-ESLEFILVQA 497
A N I + FI+VQA
Sbjct: 414 ATNNIDSVHATAFIIVQA 431
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 138 bits (347), Expect = 2e-32
Identities = 149/613 (24%), Positives = 249/613 (40%), Gaps = 32/613 (5%)
Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
S+ +S E +C V G I+W + L RIS + + + S L I
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPT-ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNIS 472
Query: 85 NANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVV 142
++ + D G+Y+C G +A +NV+ + KN G D I C V+
Sbjct: 473 SSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA----GRDTYIHCRVI 528
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARGEINF 201
+I W +K +++ + +N L++ ++K DEG Y C +L + +++
Sbjct: 529 GYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN--VLVQPQLST 585
Query: 202 -KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEP-TMSWTKDGEQIEQEED 259
+ + V V VPP IQ + ++GQ V + C P T++W KDG I
Sbjct: 586 SQSVHVTVKVPPFIQPFEF---PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLG 642
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
D +S L I + Y CIA N+A + L V PK
Sbjct: 643 -VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDG 701
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--TLDGHMVVRSHARVSSLTLKSIQY 377
+ V L C A G P+P+I W+ S + + L+G + V S+ SL +K +
Sbjct: 702 IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLLIKHVVE 758
Query: 378 TDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSAT 435
D+G Y+C SN +G D S+SMYL V+ + P +G + ++C
Sbjct: 759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPII 818
Query: 436 ISWFRDGQLLP---SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+ W ++ +++ + + K S L++ P D G ++C A+N G++
Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878
Query: 493 ILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552
L + P P I+ + + T +++ G PI Y E + + W S
Sbjct: 879 QLTVQEPPDPPEIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKSDS-WDSAQRTK 936
Query: 553 KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTP 612
+ TI+ + P +TY++R+ A N G E S T +P P P
Sbjct: 937 DVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTI-TADEAAPDGPPQEVHLEP 995
Query: 613 VPLSPPDTTWPLP 625
+ TW P
Sbjct: 996 ISSQSIRVTWKAP 1008
Score = 102 bits (255), Expect = 1e-21
Identities = 94/408 (23%), Positives = 159/408 (38%), Gaps = 29/408 (7%)
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT------PQEFREGEDAVIVCD 140
N D Y+C+ E+ + + ++F +AP+ ++ G+ + C
Sbjct: 188 NEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCK 247
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
+ P W + L + V L I I+ +D G+Y CE G
Sbjct: 248 ALGHPEPDYRWLKDNMPLELSGRFQKTVTG---LLIENIRPSDSGSYVCEVSNRYGTAKV 304
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G + K + TI R+ +++G V+L C G + +SW ++GE +
Sbjct: 305 IGRLYVKQ-----PLKATISPRK----VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC-IAENKAGEQDATIHLKVFAKPKITYVE 314
++ I + L + + K+D Y C + ++K QD + PKI
Sbjct: 356 PGKNVR--ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
++ + E V+L C G P+P+ITW I M+ VS L + S
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 473
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
Q D G Y CTA+N+ G + V+ ++ + G I C V YP
Sbjct: 474 SQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYY 533
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
+I W+++ LLP N+ + N + +V E D G Y C +
Sbjct: 534 SIKWYKNSNLLP-FNHRQVAFENNGTLKLSDV--QKEVDEGEYTCNVL 578
Score = 87.8 bits (216), Expect = 3e-17
Identities = 94/403 (23%), Positives = 143/403 (35%), Gaps = 21/403 (5%)
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G V++K + + Q+ G AV C + SS+ I
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Query: 154 KGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDE-GTYRCEGRILARGEINFKDIQVIVNVP 211
+D + L RF++ S L I+ ++ D YRC R GE + +
Sbjct: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219
Query: 212 PTIQARQ---NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P A + A GQ V L C A G PEP W KD +E +K +
Sbjct: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---- 275
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ L I+ + +D Y+C N+ G L V K T + + QV+L+
Sbjct: 276 -TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC--T 386
C +G ++W + ++ G V + +L + + +D G Y C
Sbjct: 335 CSVTGTEDQELSWYRNGEILN------PGKNVRITGINHENLIMDHMVKSDGGAYQCFVR 388
Query: 387 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
QD + LE + V++ C V P TI+W D +
Sbjct: 389 KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL 448
Query: 447 SSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG 486
I T SYL ++ D G Y CTA N G
Sbjct: 449 KGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/356 (23%), Positives = 133/356 (37%), Gaps = 66/356 (18%)
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQTAMEL 321
S DS I + +N + +A AG ++ T+ A +I
Sbjct: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW 1299
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
+ + L C+A GDP P++ W + S T+DG + S+ S +++++ D+G
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV-TIDGRRSIFSNG---SFIIRTVKAEDSG 1355
Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y C A+N G D + L+VQ P +Q +T S T+SW
Sbjct: 1356 YYSCIANNNWGSDEIILNLQVQVPP-------------DQPRLTVSKTTSSSITLSW--- 1399
Query: 442 GQLLPSSN-YSNIKIY-------NTPSASYLEVTPDSEN---------DFGNYNCTAVNR 484
LP N S+I+ Y N+ ++P + + + TA N
Sbjct: 1400 ---LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456
Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKY 533
+G + I ++A T EP S Q F T GG PI +
Sbjct: 1457 VGPGRISEI-IEAKTLGK------EPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSF 1509
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 589
E+R G VW + A+ S+ + L+ T Y +++ N G E A
Sbjct: 1510 TLEYRPFGTTVWTT----AQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQA 1561
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/108 (29%), Positives = 47/108 (43%), Gaps = 8/108 (7%)
Query: 207 IVNVPPTIQARQNIVNATANLG----QSVTLVCDAEGFPEPTMSWTKD--GEQIEQEEDD 260
I+ V P +A I+ + + + + L C A G P P + W KD G D
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+ IFS+ S I+ V D Y CIA N G + ++L+V P
Sbjct: 1335 RRSIFSNGS--FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 35.0 bits (79), Expect = 0.26
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 8/103 (7%)
Query: 133 EDAVIVCDVVSSLPPTIIWKH--KGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+D V+ C V P + W G ++ D R + SN IR +K D G Y C
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC- 1359
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
+A N+ ++I+N+ + Q + + S+TL
Sbjct: 1360 ---IANN--NWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITL 1397
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 135 bits (340), Expect = 1e-31
Identities = 162/685 (23%), Positives = 266/685 (38%), Gaps = 73/685 (10%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ C+V G+A +++W + L + R++ + + +L I D
Sbjct: 411 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 464
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G Y+CV + +G + A+V + + + + Q F +G + + C P I
Sbjct: 465 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 523
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
W + + L++D R V + L I+G+ D G Y C+ A E+ + + +
Sbjct: 524 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 577
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
PP++ A +V +G+ LVC+A G P P + W + G E I E
Sbjct: 578 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 628
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S +L I + D Y C A N+ G+ A I L V P++T + +EL L
Sbjct: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386
C A+G P P++TWR L RS S L +S+ D Y+C
Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746
Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442
A N G+ +++ + +AP V EG V++ C V A P W +DG
Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502
+ LP + +I+ + L + + G Y+C A N G + + LV
Sbjct: 807 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV---VQVP 858
Query: 503 PSIDQVEPYSSTAQ-VQFDEPEATGGV--PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P I + T + V P GV P + + E A+ H S EG
Sbjct: 859 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH------YNVSKEG 912
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VH-------SPPPPASASSST 611
+ I + A A N G T+P +H + P +A +
Sbjct: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
Query: 612 PVPLS-------PPDTTW-----PLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIK 659
V L PP TW P+P + S + Q+G+ G+
Sbjct: 973 EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH---YECTA 1029
Query: 660 QDDGGSPIRHYLVRYRALSSEWKPE 684
+ GS Y++ + +S W+P+
Sbjct: 1030 SNPAGSASHRYVLGVQGRTS-WQPQ 1053
Score = 107 bits (268), Expect = 3e-23
Identities = 90/366 (24%), Positives = 147/366 (40%), Gaps = 25/366 (6%)
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
++ C V S+LP + + + + L ++ F N+ +I K +EGTY C +
Sbjct: 328 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 384
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G K V+ + PP + N+ T + G++ L C G ++W +D +
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 441
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ L I + D Y C+A N G A++ L V P+++ +
Sbjct: 442 ASTGRVAQL---ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 498
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+V ++C ASG P P I+W S E + L + A+ +L ++ +
Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 550
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSA 434
DAG Y C A+N +G D +++ L P + A V G + + CE P
Sbjct: 551 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 610
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ W+R G I S+ L + E D G Y C AVN +G S E L
Sbjct: 611 RVIWYRGG-------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
Query: 495 VQADTP 500
P
Sbjct: 664 AVGHAP 669
Score = 89.0 bits (219), Expect = 2e-17
Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%)
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+E++ +S I + K +E Y C A ++AG A + V P +
Sbjct: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374
E L+C G+ ++TW D ++ S RV+ SL +
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 459
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429
I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C
Sbjct: 460 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 515
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G +
Sbjct: 516 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 570
Query: 490 LEFILVQADTPSSPSIDQV 508
L D PS +++ V
Sbjct: 571 ETVTLYYTDPPSVSAVNAV 589
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 132 bits (333), Expect = 9e-31
Identities = 152/614 (24%), Positives = 246/614 (40%), Gaps = 67/614 (10%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ ++WF +G K+ P+ RI++ + TL I + D
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFR-DGRKIPPSS-RIAITLEN----TLVILSTVAPD 177
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA----------PTPQEFREGEDAVIVCD 140
AG Y + +++ + + + + + A P G V +
Sbjct: 178 AGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC 237
Query: 141 VVSSLPPT---IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
V ++ P IIWK G V+L + N L I +D G Y CE + +
Sbjct: 238 VANARPLIKLHIIWKKDG--VLLSGGISD---HNRRLTIPNPTGSDAGYYECEAVLRSSS 292
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ + + P ++ + TA + + V + C A+G P P+++W KD +E E
Sbjct: 293 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 352
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-KPKITYVENQ 316
+ +D Q I + +D + C A N AGE + +L V + P IT
Sbjct: 353 KLTRFRQRNDGGLQ--ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD 410
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
+ + V L CE SG P P+ITW+ R ++S L + S SL +
Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES----GSLLISPTH 466
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSAT 435
+DAG Y C A+N+ G D S L V ++ P + +G Q ++ C V P T
Sbjct: 467 ISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT 526
Query: 436 IS--WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I W +DG L + ++ I++ S L ++ D G Y C ++ G +S
Sbjct: 527 IRYIWEKDGATLGTESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT------GGVPILKY-------KAEWRAV 540
L P +P P ++ + V+ T G P+++Y A W +
Sbjct: 584 LRVRQLPHAPE----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVL 639
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE---FKTQP 597
V D K S VT+ GL P +Y RL A+N G G+ S +E +P
Sbjct: 640 LASV------DPKATS----VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP 689
Query: 598 VHSPPPPASASSST 611
+PP AS T
Sbjct: 690 PTAPPQNVIASGRT 703
Score = 105 bits (261), Expect = 2e-22
Identities = 110/424 (25%), Positives = 167/424 (39%), Gaps = 37/424 (8%)
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTI 149
AG Y+C+V G+ + V++ F+ Q GE AVI ++S P P +
Sbjct: 86 AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE-INFKDIQVIV 208
W GR + R + N L I D G Y + G+ + I + V
Sbjct: 146 TWFRDGRKI--PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
Query: 209 N--------VPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQEE 258
+ PTI + A + VTL C A P + + W KDG +
Sbjct: 204 ENVGGPADPIAPTIIIPPKNTSVVAGTSE-VTLECVANARPLIKLHIIWKKDGVLLSGG- 261
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPK-ITYVE 314
SD + +LTI +D Y C A ++ + + +L V P+ + E
Sbjct: 262 ------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-VSSLTLK 373
E+E+ V + C+A G P PSITW + E+ T R R L +
Sbjct: 316 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT-------RFRQRNDGGLQIS 368
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431
+ D G + C A N G+ S YL V AP + +GP+ +G V + CE
Sbjct: 369 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 428
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
P I+W + ++L S + + S S L ++P +D G Y C A N G +
Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEAS 487
Query: 492 FILV 495
LV
Sbjct: 488 ADLV 491
Score = 65.5 bits (158), Expect = 2e-10
Identities = 100/423 (23%), Positives = 167/423 (39%), Gaps = 66/423 (15%)
Query: 120 FKNAPT-PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLSNNYLQIR 177
FK P Q EG V+ C S P W H R++ + R+++ S
Sbjct: 28 FKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS------- 80
Query: 178 GIKKTDEGTYRC-----EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
+ +T G YRC G +L R Q V V + + + + G++
Sbjct: 81 -LDRTHAGFYRCIVRNRMGALLQR--------QTEVQVAYMGSFEEGEKHQSVSHGEAAV 131
Query: 233 LVCD-AEGFPEPTMSWTKDGEQIEQEE------DDEKYIFS---DDSSQLTIKKV-DKND 281
+ FP+P ++W +DG +I ++ I S D+ + ++ V DKN
Sbjct: 132 IRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNG 191
Query: 282 E---AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
+ ++ I + G I + PK T V T+ +VTL C A+ P+
Sbjct: 192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS-----EVTLECVANARPLIK 246
Query: 339 --ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA---SNTIGQ 393
I W+ +S + H R LT+ + +DAG Y C A S+++
Sbjct: 247 LHIIWKKDGVLLSGG---------ISDHNR--RLTIPNPTGSDAGYYECEAVLRSSSVPS 295
Query: 394 DSQSMYLEVQYAPK-LQGPVAVYTWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYS 451
+ YL V P+ ++ P T E + V+I C+ P +I+W++D ++ +
Sbjct: 296 VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT 355
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
+ N + PD D G + C A N G+ L A T +P+I + P
Sbjct: 356 RFRQRNDGGLQISGLVPD---DTGMFQCFARNAAGEVQTSTYL--AVTSIAPNITR-GPL 409
Query: 512 SST 514
ST
Sbjct: 410 DST 412
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/108 (27%), Positives = 47/108 (43%), Gaps = 4/108 (3%)
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568
E ++ +V + EP G+ + Y+ W Y ++E VT GL
Sbjct: 905 EILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY-LPNVTLEYRVT--GLTA 960
Query: 569 ETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLS 616
TTY + +AA+ KG G++SA++ P P PP + S P S
Sbjct: 961 LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRS 1008
Score = 38.5 bits (88), Expect = 0.023
Identities = 45/187 (24%), Positives = 74/187 (39%), Gaps = 11/187 (5%)
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADT------ 499
++N + +++ PSA T + TA R G E+ E ++V +
Sbjct: 1344 TANTATVEVL-APSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP 1402
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
PS P + Q + + + + + EP + G P+ Y + R + W + A +
Sbjct: 1403 PSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRW--ALHSASVSHNAS 1459
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPD 619
+ LKP T+Y R+ A N G E S SE T +P + S TP +
Sbjct: 1460 SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVL 1519
Query: 620 TTWPLPA 626
W PA
Sbjct: 1520 IRWQPPA 1526
Score = 37.4 bits (85), Expect = 0.052
Identities = 74/345 (21%), Positives = 123/345 (35%), Gaps = 32/345 (9%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-------AKPKITYVENQTAMELE 322
+Q + ++K+ E N GE ++ +VF A P+ V TA +L+
Sbjct: 1582 TQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLD 1641
Query: 323 ---EQVTLTCEASGD--PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E L + +GD W N++ KTL +S+ LK++
Sbjct: 1642 VTWEPPPLDSQ-NGDIQGYKIYFWEAQRGNLTERVKTL--------FLAENSVKLKNLTG 1692
Query: 378 TDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
A A N G +S + Q AP V VN++ E +P+
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
Query: 435 TISWFR--DGQLLPSSNYSNIKIYNTPSAS--YLEVTPDSENDFGNYNCTAVNRIGQESL 490
+ +R P S I + S +L+V +E + A +
Sbjct: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812
Query: 491 EFILVQAD---TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
E + P P + + YSS + + + G PI +Y E R E +W
Sbjct: 1813 EANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKG-PITRYVIEARPSDEGLWDI 1871
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
D + ++ LKP +Y R+ A+N G G S+ S+
Sbjct: 1872 LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 132 bits (332), Expect = 1e-30
Identities = 135/558 (24%), Positives = 227/558 (40%), Gaps = 72/558 (12%)
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+++ F F P G ++ C S P I WK G + L D R +L
Sbjct: 46 SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105
Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
+ L I + K DEG Y+C + + G I + ++IV P ++ + A
Sbjct: 106 DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
G + L C+ P + W ++ + + ++ + S L I + D Y
Sbjct: 166 --GNNAILNCEVNADLVPFVRWEQNRQPLLLDDR----VIKLPSGMLVISNATEGDGGLY 219
Query: 286 ICIAENKAGEQDAT-IHLKVFAKPKI----TYVENQTAME--LEEQVTLTCEASGDPIPS 338
C+ E+ + + + LKV P++ +++ + + + + V L C ASG P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
I W + + +E +V+ + SL + + DAG Y C A N
Sbjct: 280 IKWMKNEEALDTESSE---RLVLLAGG---SLEISDVTEDDAGTYFCIADNGNETIEAQA 333
Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL-LPSSNYSNIKIY 456
L VQ P+ L+ P +Y E + CEV P+ T+ W ++G + +PS + +K +
Sbjct: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH 393
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQ---ADTPSSPSIDQVEPY 511
N L+V ++D G Y C A N +G Q + I+++ A T PS + +
Sbjct: 394 N------LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPR-DVV 446
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAV-----GEEVWHSKWYDAKEASMEGI------ 560
+S +F K WR G+ + +S +Y + + E +
Sbjct: 447 ASLVSTRF-------------IKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHP 493
Query: 561 ----VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP---VHSPPPPASASSSTPV 613
VTI L P T Y R+ A N G GE SA +TQP + P P A +++P
Sbjct: 494 GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT 553
Query: 614 PLSPPDTTWPLPALATTE 631
++ TW P E
Sbjct: 554 SIT---VTWETPVSGNGE 568
Score = 102 bits (254), Expect = 1e-21
Identities = 139/629 (22%), Positives = 226/629 (35%), Gaps = 95/629 (15%)
Query: 10 TLFFLGTAVSLQVDIV----------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG 59
T+ LGT +S ++ P + G + C+V D + W N
Sbjct: 132 TVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF-VRW-EQNR 189
Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG------EDGSESEATVNVK 113
+ L + + I + S L I NA D G+Y+CVV D E + + +
Sbjct: 190 QPLLLDDRVIKL-----PSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244
Query: 114 IFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNN 172
+ L+F P+P G+D V+ C V S LP PTI W + + R ++L+
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGG 303
Query: 173 YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
L+I + + D GTY C +A + Q + V + + N A+ +
Sbjct: 304 SLEISDVTEDDAGTYFC----IADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359
Query: 233 LVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
C+ G P PT+ W K+G+ + + Y L + + K+DE Y CIAEN
Sbjct: 360 FECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVKSDEGFYQCIAEND 415
Query: 293 AGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE 352
G A L + T +A + +TWRT + +
Sbjct: 416 VGNAQAGAQLIILEHAPATTGPLPSAPR-----DVVASLVSTRFIKLTWRTPASDPHGDN 470
Query: 353 KTLD----------GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
T + SH +T++++ + A N G S L V
Sbjct: 471 LTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530
Query: 403 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 462
+ P++Q P G N+ + S T++W + + + N K+Y
Sbjct: 531 ETQPEVQLP-------GPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKLY------ 575
Query: 463 YLEVTPDSENDFG----NYNCTAVNRIGQESLEFILVQADTP--SSP--------SIDQV 508
Y+E D E D +Y + + + S + P S+P +
Sbjct: 576 YMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSA 635
Query: 509 EPYSSTAQVQFDE---------PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + + +V+ + AT I YK +R S+ D E + G
Sbjct: 636 APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA------SRKSDVTETLVSG 689
Query: 560 I---VTIVGLKPETTYAVRLAALNGKGLG 585
I GL T Y R+AAL G G
Sbjct: 690 TQLSQLIEGLDRGTEYNFRVAALTINGTG 718
Score = 32.7 bits (73), Expect = 1.3
Identities = 40/156 (25%), Positives = 59/156 (37%), Gaps = 13/156 (8%)
Query: 492 FILVQADTPSSPSIDQVEPYSSTAQVQFDEP-EATGGVP--ILKYKAEWRAVGEEVWHSK 548
F LV P ++ E T V + P EA G + I+ Y + V E+
Sbjct: 950 FELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTD---VNAEI--HD 1004
Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS----PPPP 604
W I L +T Y ++ A N KG+G +S A +F+T S P
Sbjct: 1005 WVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQ 1064
Query: 605 ASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAP 640
AS S L + + P + P G P++P
Sbjct: 1065 ASGSGGKGSRLPDLGSDYKPPMSGSNSP-HGSPTSP 1099
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 129 bits (325), Expect = 8e-30
Identities = 145/575 (25%), Positives = 228/575 (39%), Gaps = 53/575 (9%)
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
NA +E R G + C + LP II+ K D +L K+ LQI + +
Sbjct: 270 NASNKEELR-GNVLSLEC-IAEGLPTPIIYWAK-EDGMLPKNRTVYKNFEKTLQIIHVSE 326
Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
D G Y+C + A G I+ + P I A QN+V + G+ TL+C A G P
Sbjct: 327 ADSGNYQCIAKN-ALGAIHHTISVRVKAAPYWITAPQNLVLSP---GEDGTLICRANGNP 382
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
+P +SW +G IE DD D+ + V + A Y C A N+ G A
Sbjct: 383 KPRISWLTNGVPIEIAPDDPSRKIDGDT--IIFSNVQERSSAVYQCNASNEYGYLLANAF 440
Query: 302 LKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359
+ V A+P T ++ L C G P+P+I W + + E H
Sbjct: 441 VNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH- 499
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWE 418
+L + Q G Y C A N +G ++LE++ + + P
Sbjct: 500 ------ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553
Query: 419 GNQVNITCEVFAYP--SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
G+ V+ C+V S T+ W +D + LPS + +L V S++D G
Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV------DKDHLVVADVSDDDSGT 607
Query: 477 YNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 535
Y C A + S +L D P+ P ++ + + Q+ + P PI K+
Sbjct: 608 YTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFII 666
Query: 536 EWRAVGEEVWHSK--WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
E+ E+ H W+ E S + L P Y+ R+ A+N G S ASE
Sbjct: 667 EY----EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQ 722
Query: 594 KTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKG-EPSAPKLEGQMG---ED 649
P +A S PD + T +P G E + P L+ ++ +D
Sbjct: 723 YLTKASEPDKNPTAVEGLG---SEPDN-----LVITWKPLNGFESNGPGLQYKVSWRQKD 774
Query: 650 GNS-----IKVNLIKQDDGGSP-IRHYLVRYRALS 678
G+ + N+ K G+P YL++ +AL+
Sbjct: 775 GDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALN 809
Score = 96.7 bits (239), Expect = 7e-20
Identities = 106/437 (24%), Positives = 165/437 (37%), Gaps = 55/437 (12%)
Query: 92 GIYKCVVTGEDGSESEATVNVKIFQK-LMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G+Y+C E G+ + V+ + L K P + G+ V+ C LPP II
Sbjct: 113 GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPII 172
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD-EGTYRCEGR------ILARGEINFKD 203
+ L + R N L + D Y C R I + I+ K
Sbjct: 173 FWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232
Query: 204 IQV-------IVNV--------------PPTIQARQ-NIVNATANLGQSVTLVCDAEGFP 241
I V N+ PPT + N N G ++L C AEG P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
P + W K+ + + + ++ + L I V + D Y CIA+N G TI
Sbjct: 293 TPIIYWAKEDGMLPKN----RTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTIS 348
Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI----SSEEKTLDG 357
++V A P + E TL C A+G+P P I+W T+ I + +DG
Sbjct: 349 VRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDG 408
Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPV-AVY 415
++ S ++Q + Y C ASN G + ++ V P++ P +Y
Sbjct: 409 DTIIFS----------NVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLY 458
Query: 416 TWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
N+ + C F P TI WF+ + + + IY LE+ ++
Sbjct: 459 QVIANRPALLDCAFFGSPLPTIEWFKGAK----GSALHEDIYVLHENGTLEIPVAQKDST 514
Query: 475 GNYNCTAVNRIGQESLE 491
G Y C A N++G E
Sbjct: 515 GTYTCVARNKLGMAKNE 531
Score = 96.7 bits (239), Expect = 7e-20
Identities = 117/529 (22%), Positives = 199/529 (37%), Gaps = 59/529 (11%)
Query: 80 TLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139
TL I + + D+G Y+C+ G+ T++V++ + AP GED ++C
Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALGAIHH-TISVRVKAAPYWITAPQNLVLSPGEDGTLIC 376
Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRIL 194
+ P I W G + + D + + + +++ Y+C G +L
Sbjct: 377 RANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLL 436
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
A +N V+ P + + AN + L C G P PT+ W K +
Sbjct: 437 ANAFVN-----VLAEPPRILTPANTLYQVIAN--RPALLDCAFFGSPLPTIEWFKGAKGS 489
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
ED Y+ ++ + L I K+ Y C+A NK G +HL++ I
Sbjct: 490 ALHEDI--YVLHENGT-LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQP 546
Query: 315 NQTAMELEEQVTLTCEASGDPIPSIT--WRTSTRNISSEEKTLDGHMVVRSHARVSSLTL 372
++ V+ C+ D S+T W R + S+E+ V + H L +
Sbjct: 547 EYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDER----FTVDKDH-----LVV 597
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTWEGNQV 422
+ D+G Y C A+ T+ S S L V P +L V + G+
Sbjct: 598 ADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDN 657
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
N F I + D P + ++ T + + L+++P F AV
Sbjct: 658 NSPITKF------IIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSF---RVMAV 708
Query: 483 NRIGQ----ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGV----PILKYK 534
N IG+ E+ E L +A P + VE S + G P L+YK
Sbjct: 709 NSIGKSLPSEASEQYLTKASEPDK-NPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYK 767
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
WR ++ +W A++ + + G Y +++ ALN G
Sbjct: 768 VSWR---QKDGDDEWTSVVVANVSKYI-VSGTPTFVPYLIKVQALNDMG 812
Score = 78.6 bits (192), Expect = 2e-14
Identities = 160/738 (21%), Positives = 275/738 (37%), Gaps = 126/738 (17%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDS----SSTL 81
P +S GE +C+ G+ K + ISW + N I + +D S T+
Sbjct: 361 PQNLVLSPGEDGTLICRANGNPKPR-ISWLT--------NGVPIEIAPDDPSRKIDGDTI 411
Query: 82 TIYNANIDDAGIYKCVVTGEDGSE-SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
N + +Y+C + E G + A VNV + A T + A++ C
Sbjct: 412 IFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCA 471
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI---LARG 197
S PTI W + L +D+ +++ N L+I +K GTY C R +A+
Sbjct: 472 FFGSPLPTIEWFKGAKGSALHEDI-YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKN 530
Query: 198 EINF--KDIQVIVNVPP-TIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
E++ KD IV P + R ++V+ + TL T+ W KD ++
Sbjct: 531 EVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSL--------TVLWLKDNREL 582
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
+E F+ D L + V +D Y C+A A+ L V P + +
Sbjct: 583 PSDER-----FTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPF-D 636
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+ +L++ V L+ D IT + + L H S + ++ LK
Sbjct: 637 LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTA-QLKL 695
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---------------VYTWEG 419
Y + + A N+IG+ S E QY K P V TW+
Sbjct: 696 SPYVNYS-FRVMAVNSIGKSLPSEASE-QYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 753
Query: 420 -NQVNITCEVFAYPSATISWF-RDGQ----LLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
N Y +SW +DG + +N S + TP+ + + ND
Sbjct: 754 LNGFESNGPGLQYK---VSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALND 810
Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY 533
G AV +G + +V P + ++ V S+ A+V +D VP+
Sbjct: 811 MGFAPEPAVV-MGHSGEDLPMV---APGNVRVNVVN--STLAEVHWDP------VPLKSI 858
Query: 534 KAE--------WRAVGEEVWHSKWYDAKEASMEGIVT---IVGLKPETTYAVRLAALNGK 582
+ W+ + + + K + +G T + GL+P + Y + + +NGK
Sbjct: 859 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 918
Query: 583 GLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKL 642
G G PAS PD + P +G PSAP
Sbjct: 919 GEG------------------PAS-----------PDRVFNTP--------EGVPSAPSS 941
Query: 643 EGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS--EWKP--EIRLPSGSDHVMLKS 698
+ +S+ + + Y ++Y+ ++S E P ++++P+ LK+
Sbjct: 942 LKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKN 1001
Query: 699 LDWNAEYEVYVVAENQQG 716
L+++ Y+ Y A+ G
Sbjct: 1002 LNFSTRYKFYFYAQTSAG 1019
Score = 62.4 bits (150), Expect = 2e-09
Identities = 92/410 (22%), Positives = 147/410 (35%), Gaps = 59/410 (14%)
Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN-----YLQIRGIKKTDEGTY 187
E+ VI C+ PP+ W G + KD + + G +T EG Y
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 115
Query: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE-GFPEPTMS 246
+C R RG +I V + P + ++ + T GQS+ L C G P P +
Sbjct: 116 QCTAR-NERGAAVSNNIVVRPSRSP-LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF 173
Query: 247 WTKDG-EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE-YICIA---ENKAGEQDATIH 301
W + +++ Q E + + D L V D E YIC A + +Q I
Sbjct: 174 WMDNSFQRLPQSERVSQGLNGD----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPIS 229
Query: 302 LKVFA-------------------------KPKITYVENQTAMELEE----QVTLTCEAS 332
+KV + +P A EE ++L C A
Sbjct: 230 VKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE 289
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P I W + E+ L + V + +L + + D+G Y C A N +G
Sbjct: 290 GLPTPIIYW-------AKEDGMLPKNRTVYKNFE-KTLQIIHVSEADSGNYQCIAKNALG 341
Query: 393 QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
++ + V+ AP + P + G + C P ISW +G + +
Sbjct: 342 AIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD 401
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTP 500
+ + + + V E Y C A N G + F+ V A+ P
Sbjct: 402 PSRKIDGDTIIFSNV---QERSSAVYQCNASNEYGYLLANAFVNVLAEPP 448
Score = 52.8 bits (125), Expect = 1e-06
Identities = 74/324 (22%), Positives = 124/324 (38%), Gaps = 69/324 (21%)
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPTI +Q+ + + +++ + C+A+G P P+ SWT++G + ++ D +
Sbjct: 39 PPTI-TQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK-DPLVTMKPGTG 96
Query: 271 QLTIKKVDKND----EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-----L 321
L I + + E Y C A N+ G A + + +P + + + +E
Sbjct: 97 TLIINIMSEGKAETYEGVYQCTARNERG---AAVSNNIVVRPSRSPLWTKEKLEPITLQS 153
Query: 322 EEQVTLTCEAS-GDPIPSITWR-TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ + L C G P P I W S + + E+ S L ++ D
Sbjct: 154 GQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERV--------SQGLNGDLYFSNVLPED 205
Query: 380 AGE-YICTA----SNTIGQDSQSMYLEVQYAPKLQGPVAV-------------------- 414
E YIC A + TI Q Q + ++V +L +A
Sbjct: 206 TREDYICYARFNHTQTI-QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF 264
Query: 415 YTWEGNQVN----------ITCEVFAYPSATISWFRDGQLLPSSN--YSNIKIYNTPSAS 462
T EGN N + C P+ I W ++ +LP + Y N +
Sbjct: 265 LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-------K 317
Query: 463 YLEVTPDSENDFGNYNCTAVNRIG 486
L++ SE D GNY C A N +G
Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALG 341
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 127 bits (320), Expect = 3e-29
Identities = 164/721 (22%), Positives = 267/721 (37%), Gaps = 88/721 (12%)
Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
QV + P+ G + C V + +++W NG++L + + V+ + T
Sbjct: 37 QVTVQPASTVQKPGGTVILGCVV--EPPRMNVTW-RLNGKELNGSDDALGVLI---THGT 90
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK-NAPTPQEFREGEDAVIVC 139
L I N G Y+CV G+ + V + FK + E EG AVI C
Sbjct: 91 LVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIAC 150
Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
+ S P + ++ + ++++ + LQI + DEG Y+C E+
Sbjct: 151 HLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEV 210
Query: 200 NFKDIQVIVNVPPTIQARQNIV------NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
+ V + I+ GQS+ L C A G P P ++W KDG
Sbjct: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSS 270
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPKI 310
+ + S L I + D Y C+A+N G+ A + +++VF P++
Sbjct: 271 VTGYNKTRFLL-----SNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEV 325
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITW-RTSTRNISSEEKTLDGHMVVRSHARVSS 369
T +Q + + LTCE G+P PS+ W R + ISS+ L +
Sbjct: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR----------A 375
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVF 429
L + S+ D G Y C A N +G + L
Sbjct: 376 LRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT--------------------------- 408
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY--LEVTPDSENDFGNYNCTAVNRIGQ 487
+ PS T ++D +L + + P P G + GQ
Sbjct: 409 SRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQ 468
Query: 488 ESLEFILVQADTP---SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEV 544
+ A+ P SSP + + Y V E +G PIL Y + R V
Sbjct: 469 GA------PAEAPIILSSPRTSKTDSYE---LVWRPRHEGSGRAPILYYVVKHRKVTNS- 518
Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPP 604
W + + + +T+ L P + Y V +AA N G G+ +A F+T P P
Sbjct: 519 -SDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQ-TAMVTFRTG--RRPKPE 574
Query: 605 ASASSSTPVPLSPPDTTWPLPALATTEPAKGE---PSAPKLEGQMGEDGNSIKVNLIKQD 661
AS + P + ++++P G P AP S+ V I +
Sbjct: 575 IMASKEQQIQRDDPGAS----PQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRG 630
Query: 662 DGGSPIRHYLVRYRALS--SEW-KPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 718
+GG PI+ + V Y+ L +W +P V + L+ Y+ V A N G+S
Sbjct: 631 NGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGES 690
Query: 719 K 719
+
Sbjct: 691 E 691
Score = 75.9 bits (185), Expect = 1e-13
Identities = 116/555 (20%), Positives = 208/555 (37%), Gaps = 84/555 (15%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G +V L C E P ++W +G+++ +D + + + L I ++ + Y C
Sbjct: 50 GGTVILGCVVEP-PRMNVTWRLNGKELNGSDDALGVLITHGT--LVITALNNHTVGRYQC 106
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT--LTCEASGDPIPSITWRTST 345
+A AG + A + ++ Q +E++E T + C + P R S
Sbjct: 107 VARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP-ESHPKAQVRYSV 165
Query: 346 RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD----------- 394
+ E + ++++ S +L + + D G Y C A N + Q+
Sbjct: 166 KQ-EWLEASRGNYLIMPS----GNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLR 220
Query: 395 ---SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
S + + Y P+ Q + +G + + C P ++W +DG + N +
Sbjct: 221 VRRSTAEAARIIYPPEAQ---TIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKT 277
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ---- 507
+ N L + SE D G Y C A N +GQ IL P +
Sbjct: 278 RFLLSN------LLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQ 331
Query: 508 -VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL 566
V P+ +A++ E G P W + S+ ++ ++ +
Sbjct: 332 LVIPWGQSAKLTC---EVRGNPP---PSVLWLRNAVPLISSQRLRLSRRALR----VLSM 381
Query: 567 KPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPP---PPASASSSTPVPLSPPDTTWP 623
PE + A N +G A + +T P A ++ TP P+SP P
Sbjct: 382 GPEDEGVYQCMAEN--EVGSAHAVVQLRTSRPSITPRLWQDAELATGTP-PVSPSKLGNP 438
Query: 624 ------LPALATTEPAKGEPSAPKLEGQMGE------------------DGNSIKVNLIK 659
PAL + G P++P+ G+ G+ D +
Sbjct: 439 EQMLRGQPALPRPPTSVG-PASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRH 497
Query: 660 QDDGGSPIRHYLVRYRAL---SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 716
+ G +PI +Y+V++R + S +W +P+ + L LD + YEV + A N G
Sbjct: 498 EGSGRAPILYYVVKHRKVTNSSDDWTIS-GIPANQHRLTLTRLDPGSLYEVEMAAYNCAG 556
Query: 717 KSKAAHFVFRTSAQP 731
+ + A FRT +P
Sbjct: 557 EGQTAMVTFRTGRRP 571
Score = 36.2 bits (82), Expect = 0.12
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRA---VGEEVWHSKWYDAKEAS 556
P +P + S T+ P GG PI ++ E++ VG+ + + S
Sbjct: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591
+E I GL+ T+Y R+ ALN G E SA S
Sbjct: 666 VE----ITGLEKGTSYKFRVRALNMLGESEPSAPS 696
Score = 32.7 bits (73), Expect = 1.3
Identities = 26/90 (28%), Positives = 35/90 (38%), Gaps = 23/90 (25%)
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
G++ WHS I L+PET+Y +++ N G E S +T+
Sbjct: 770 GDKYWHS---------------ISHLQPETSYDIKMQCFNEGGESEFSNVMICETK---- 810
Query: 601 PPPPASASSSTPVPLSPPDTTWPLPALATT 630
A SS P L PP P P L T
Sbjct: 811 ----ARKSSGQPGRLPPPTLAPPQPPLPET 836
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 127 bits (318), Expect = 5e-29
Identities = 123/503 (24%), Positives = 207/503 (41%), Gaps = 41/503 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPN-GEKLTPNQ--QRISVVWNDDSSSTLT 82
P ++ F C+ G K ++W + G +TPN QR V+ N TL
Sbjct: 1860 PQTVSVTAETDTVFPCEATGKPKPF-VTWTKVSTGALMTPNTRIQRFEVLKN----GTLV 1914
Query: 83 IYNANIDDAGIYKCVVTGEDGSESEATV-NVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
I + D G Y C + G + + +V + Q + + G+ + C
Sbjct: 1915 IRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLA 1974
Query: 142 VSSLPPTIIWKHKGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
+ P I W R V + + R + N L I+ +D G Y+C A +
Sbjct: 1975 KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGAD 2034
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQIEQE 257
+ V +PP I ++ + N + G S+ + C A+ P P++ W DG QI
Sbjct: 2035 SLAIRLHVAA-LPPVIH-QEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPS 2092
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV---FAKPKITYVE 314
+ +F + L I+ + D Y C+A N G T+ L V A +IT
Sbjct: 2093 QFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTS 2152
Query: 315 -NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK 373
+T + + L C ASGDP P I WR ++ + + D + V ++ +L +K
Sbjct: 2153 PRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG---TLVVK 2209
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP-----KLQGPVAVYTWEGNQVNITCEV 428
S+ DAG+Y+C A N +G D + ++V P K + V+ G + + C
Sbjct: 2210 SVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY--GGDLKVDCVA 2267
Query: 429 FAYPSATISW-FRDGQLLPSSNYSNIK--------IYNTPSASYLEVTPDSENDFGNYNC 479
P+ ISW DG L+ S S+ ++N + + EV E G+Y C
Sbjct: 2268 TGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREE---GDYTC 2324
Query: 480 TAVNRIGQESLEFILVQADTPSS 502
A N++G++ + + P++
Sbjct: 2325 FAENQVGKDEMRVRVKVVTAPAT 2347
Score = 114 bits (286), Expect = 3e-25
Identities = 94/385 (24%), Positives = 162/385 (42%), Gaps = 25/385 (6%)
Query: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR---FIVLSNNYLQIRGIKKTDEGTYRCE 190
D V C+ P + W ++ + R F VL N L IR ++ D G Y C
Sbjct: 1870 DTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCT 1929
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
L + + V V P + + V T LG ++ + C A+G P P +SW
Sbjct: 1930 ASNLHGLDRMVVLLSVTVQQPQILASHYQDV--TVYLGDTIAMECLAKGTPAPQISWIFP 1987
Query: 251 GEQIEQEEDD-EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
++ Q E I ++ L+IK+ +D Y C+A N AG I L V A P
Sbjct: 1988 DRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPP 2047
Query: 310 ITYVENQTAMELEE--QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+ + E + L + + C A P+PS+ W + L G++ V +
Sbjct: 2048 VIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPN--- 2104
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA---PKLQG--PVAVYTWEGNQV 422
+L ++++ D+G Y C A+N +G +++ L VQ A ++ G P G +
Sbjct: 2105 GTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTL 2164
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNY---SNIKIYNTPSASYLEVTPDSENDFGNYNC 479
+ C P I W + + + + S IK++ + VT + D G+Y C
Sbjct: 2165 KLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVT---DKDAGDYLC 2221
Query: 480 TAVNRIGQESLEFILVQADTPSSPS 504
A N++G ++++++ D P+
Sbjct: 2222 VARNKVGD---DYVVLKVDVVMKPA 2243
Score = 111 bits (278), Expect = 2e-24
Identities = 109/464 (23%), Positives = 191/464 (41%), Gaps = 45/464 (9%)
Query: 52 ISWFSPNG---EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEA 108
ISW P+ + ++P + RI++ N TL+I A+ D G+YKCV + G++S A
Sbjct: 1982 ISWIFPDRRVWQTVSPVEGRITLHEN----RTLSIKEASFSDRGVYKCVASNAAGADSLA 2037
Query: 109 T-VNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV--- 164
++V ++ + G I C ++ P++ W I
Sbjct: 2038 IRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
Query: 165 RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG-----EINFKDIQVIVNVPPTIQARQN 219
V N L IR + D G Y C L ++N + + T R +
Sbjct: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS-------SQL 272
+ G ++ L C A G P P + W +++ +FS DS L
Sbjct: 2158 V-----RYGGTLKLDCSASGDPWPRILWRLPSKRMIDA------LFSFDSRIKVFANGTL 2206
Query: 273 TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP-KITY-VENQTAMELEEQVTLTCE 330
+K V D +Y+C+A NK G+ + + V KP KI + EN + + + C
Sbjct: 2207 VVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCV 2266
Query: 331 ASGDPIPSITWRTSTRN-ISSEEKTLDGHMVVRSHARVSSLTL--KSIQYTDAGEYICTA 387
A+G P P I+W + ++S ++ D + + ++ TL + + G+Y C A
Sbjct: 2267 ATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFA 2326
Query: 388 SNTIGQDSQSMYLEVQYAP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
N +G+D + ++V AP + + +AV G+ V + CE P ++W
Sbjct: 2327 ENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNK 2386
Query: 445 LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
+ ++ +IY + L + +D GNY C N G++
Sbjct: 2387 VIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTCLVRNSAGED 2427
Score = 108 bits (269), Expect = 2e-23
Identities = 109/481 (22%), Positives = 187/481 (38%), Gaps = 38/481 (7%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
++ G+ C+ G+ K ++W SP + + + ++ + TL I A
Sbjct: 2357 QVPYGDVVTVACEAKGEPMPK-VTWLSPTNKVIPTSSEKYQIY----QDGTLLIQKAQRS 2411
Query: 90 DAGIYKCVVTGEDGSESEAT-VNVKIFQKLMFKNAPTPQEFRE----GEDAVIVCDVVSS 144
D+G Y C+V G + + ++V + + N RE G +I C
Sbjct: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGI 2471
Query: 145 LPPTIIWKHKGRDVILKKDV---RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF 201
P ++W V+L R V N L IR ++K+D C R
Sbjct: 2472 PTPRVLWAFP-EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI 2530
Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDD 260
+ V+ + I TA G +++L C A G P P++ W +G ++ +
Sbjct: 2531 LQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL 2590
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT-YVENQTAM 319
+++ D L I + D Y C+A N AG + + LKV KP+ N ++
Sbjct: 2591 QRFYHKADG-MLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSI 2649
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E + L C G +W T + E G + + + +LT++ D
Sbjct: 2650 INGETLKLPCTPPGAGQGRFSW-TLPNGMHLEGPQTLGRVSLLDN---GTLTVREASVFD 2705
Query: 380 AGEYICTASNTIGQDSQSM-YLEVQYAPKL--QGPVAVYTWEGNQVNITCEVFAYPSATI 436
G Y+C G S+ + + Y P++ + +YT GN V + C P A I
Sbjct: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765
Query: 437 SWFRDGQLLPSSNY----SNIKIYNT----PSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
+W LP ++ ++Y P S L + ++ D G Y C A N +G +
Sbjct: 2766 TW-----ELPDKSHLKAGVQARLYGNRFLHPQGS-LTIQHATQRDAGFYKCMAKNILGSD 2819
Query: 489 S 489
S
Sbjct: 2820 S 2820
Score = 87.8 bits (216), Expect = 3e-17
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 6/185 (3%)
Query: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK----DVRFIVLSNNYLQIRGIKKT 182
Q EG + C+V +S P+I W ++ D +F +LS+ +L+I+ ++ +
Sbjct: 489 QTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPS 548
Query: 183 DEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPE 242
D G Y+C ++ R E++ +V+V P T A ++ V N G+SVTL C+A PE
Sbjct: 549 DSGLYQCIAQV--RDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPE 606
Query: 243 PTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHL 302
+SW +I + + +++ + L+I KV +D Y C+A N+ G T+ +
Sbjct: 607 AHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGI 666
Query: 303 KVFAK 307
V K
Sbjct: 667 TVTKK 671
Score = 78.6 bits (192), Expect = 2e-14
Identities = 93/387 (24%), Positives = 158/387 (40%), Gaps = 27/387 (6%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ--QRISVVWNDDSSSTLTIYNAN 87
EI+ G S+ + A + W P G L RI+V N +L I +
Sbjct: 2454 EIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN----GSLDIRSLR 2509
Query: 88 IDDAGIYKCVVTGEDGSESEATVNVKIFQ---KLMFKNAPTPQEFRE--GEDAVIVCDVV 142
D+ C+ E G E+ + + + + K +F + P ++ G + C
Sbjct: 2510 KSDSVQLVCMARNE-GGEARLILQLTVLEPMEKPIFHD-PISEKITAMAGHTISLNCSAA 2567
Query: 143 SSLPPTIIWK-HKGRDVILKKDV-RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ P+++W G D+ + + RF ++ L I G+ D G YRC R A
Sbjct: 2568 GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER 2627
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEED 259
++V + P + N+V+ G+++ L C G + SWT +G +E +
Sbjct: 2628 LVSLKVGLK-PEANKQYHNLVSIIN--GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQT 2684
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+ D+ + LT+++ D Y+C E + G +I + V A P E +
Sbjct: 2685 LGRVSLLDNGT-LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVI 2743
Query: 320 ELE--EQVTLTCEASGDPIPSITWRTSTRNI--SSEEKTLDGHMVVRSHARVSSLTLKSI 375
V L C A G P ITW ++ + + L G+ + SLT++
Sbjct: 2744 YTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQG---SLTIQHA 2800
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEV 402
DAG Y C A N +G DS++ Y+ V
Sbjct: 2801 TQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Score = 67.0 bits (162), Expect = 6e-11
Identities = 63/218 (28%), Positives = 95/218 (43%), Gaps = 19/218 (8%)
Query: 293 AGEQDATIHLKVFAKPKITYVENQT-AMELEEQVTLTCEASGDPIPSITW-RTSTRNISS 350
AG A+ + KP+I QT ++ E CEA+G P P +TW + ST + +
Sbjct: 1838 AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMT 1897
Query: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYA 405
+ V+++ +L ++ +Q D G+Y+CTASN G D + L V Q
Sbjct: 1898 PNTRIQRFEVLKN----GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQIL 1953
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQL--LPSSNYSNIKIYNTPSAS 462
V VY G+ + + C P+ ISW F D ++ S I ++ + S
Sbjct: 1954 ASHYQDVTVYL--GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLS 2011
Query: 463 YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
E S +D G Y C A N G +SL L A P
Sbjct: 2012 IKEA---SFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/279 (25%), Positives = 105/279 (37%), Gaps = 28/279 (10%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C AG + W PNG L QQ D L I + DAG Y+CV
Sbjct: 2564 CSAAG-TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM--LHISGLSSVDAGAYRCVARN 2620
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV-IVCDVVSSLPPTIIWKHKGR-DV 158
G +E V++K+ K P+ ++ + V I+ LP T +GR
Sbjct: 2621 AAG-HTERLVSLKVGLK--------PEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW 2671
Query: 159 ILKKDV---------RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
L + R +L N L +R D GTY C + + +++
Sbjct: 2672 TLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPV-IVIA 2730
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKY--IFS 266
PP I + V T G +V L C A G P+ ++W D ++ Y F
Sbjct: 2731 YPPRITSEPTPVIYTRP-GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFL 2789
Query: 267 DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
LTI+ + D Y C+A+N G T ++ VF
Sbjct: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/221 (24%), Positives = 85/221 (38%), Gaps = 8/221 (3%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
Q T KKV + +Y K Q A V +P +QT +E L+C
Sbjct: 445 QSTAKKVLLSYYTQYSQTISTKDTRQ-ARGRSWVMIEPSGAVQRDQTVLE-GGPCQLSCN 502
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
PSI W +I + +D S L +KS++ +D+G Y C A
Sbjct: 503 VKASESPSIFWVLPDGSIL--KAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVR 560
Query: 391 IGQDSQSMYLEVQYA---PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS 447
D + VQ P + V + G V + C A P A +SW + + +
Sbjct: 561 DEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIIN 620
Query: 448 SNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
+ +Y P+ + L + +D G Y C AVN+ G +
Sbjct: 621 DLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQGAD 660
Score = 38.9 bits (89), Expect = 0.018
Identities = 36/161 (22%), Positives = 65/161 (40%), Gaps = 18/161 (11%)
Query: 41 CQVAGDAKDKD---ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCV 97
CQ++ + K + I W P+G L ++ SS L I + D+G+Y+C+
Sbjct: 497 CQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCI 556
Query: 98 VTGEDGSESEATVNVKIFQKLMFKNAPTPQE-------FREGEDAVIVCDVVSSLPPTII 150
D ++ +++ L+ + P E GE + C+ ++ +
Sbjct: 557 AQVRD------EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
Query: 151 WKHKGRDVI--LKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
W R +I L +L N L I ++ +D G YRC
Sbjct: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
Score = 32.0 bits (71), Expect = 2.2
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 8/86 (9%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTP--NQQRISVVWNDDSSSTLTIYNANIDDA 91
GES C + +SW PN + N + ++ N TL+I + D+
Sbjct: 592 GESVTLPCNALA-IPEAHLSWILPNRRIINDLANTSHVYMLPN----GTLSIPKVQVSDS 646
Query: 92 GIYKCVVTGEDGSESEATVNVKIFQK 117
G Y+CV + G++ TV + + +K
Sbjct: 647 GYYRCVAVNQQGAD-HFTVGITVTKK 671
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 126 bits (317), Expect = 7e-29
Identities = 163/732 (22%), Positives = 278/732 (37%), Gaps = 87/732 (11%)
Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
S+ ++ GE +C G A ++W + + R + D + S + +
Sbjct: 475 SEKVVNPGEQFSLMCAAKG-APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVT 533
Query: 85 NANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIV 138
I D G+Y+C GS E +A +NV+ P+ + R G D +I
Sbjct: 534 GPQIRDGGVYRCTARNLVGSAEYQARINVR--------GPPSIRAMRNITAVAGRDTLIN 585
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARG 197
C V+ +I W ++L + R +V N L++ ++K DEG Y C I +
Sbjct: 586 CRVIGYPYYSIKWYKDA--LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT-MSWTKDGEQIEQ 256
I+ + + V V VPP IQ + A++GQ + + C P ++W KDG+ I
Sbjct: 644 SIS-QSVHVAVKVPPLIQPFEF---PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699
Query: 257 EE----DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
+ ++++ S L I V Y CIA N A L V P+
Sbjct: 700 GSGVTIESKEFM-----SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754
Query: 313 VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGHMVVRSHARVSS 369
N + L C G P P + W+ + + + ++ L G + + + SS
Sbjct: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN---SS 811
Query: 370 LTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCE 427
L ++ + D G Y+C ASN +G D S+SM+L V+ + P +G+ + C
Sbjct: 812 LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCT 871
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS----ASYLEVTPDSENDFGNYNCTAVN 483
I W + ++ I + S L++ P D ++C A+N
Sbjct: 872 ARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAIN 931
Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543
G++ L + P P ++ E + + +++ + G I + E++ +
Sbjct: 932 SYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDS 990
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPP 603
W K + IV L P + Y++R+ + N G E S T+ P
Sbjct: 991 -WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGP 1049
Query: 604 PASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDG 663
P + PV TW APK E Q G
Sbjct: 1050 PMDVTLQ-PVTSQSIQVTW---------------KAPKKELQNG---------------- 1077
Query: 664 GSPIRHYLVRYRALSSEWK-----PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 718
IR Y + YR S E++ S+ L +L A+Y V V A N+ G
Sbjct: 1078 --VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG 1135
Query: 719 KAAHFVFRTSAQ 730
++ + T+ +
Sbjct: 1136 PSSSEINATTLE 1147
Score = 108 bits (270), Expect = 2e-23
Identities = 121/509 (23%), Positives = 197/509 (38%), Gaps = 54/509 (10%)
Query: 66 QQRISVV-WNDDSSSTLT-----------IYNANI---DDAGIYKCVVTGEDGSESEATV 110
Q+ +SVV W D+ S + +Y +++ D Y+C+ + E+ +
Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272
Query: 111 NVKIFQKLMFKNAPT------PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
++ ++ PT QE G + C P I W GR L D
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--LPADS 330
Query: 165 RFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQN 219
R+ L I ++ D GTY CE G A G + D + P ++
Sbjct: 331 RWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT--- 386
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
+G +V L C G PE T+ W ++ E + +E S+++ L I K
Sbjct: 387 ------GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET--LLITSAQK 438
Query: 280 NDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
+ Y C A KA QD I P+I ++ + EQ +L C A G P P+
Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
+TW I + + +S + + Q D G Y CTA N +G
Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNT 458
+ V+ P ++ + G I C V YP +I W++D LLP N+ + N
Sbjct: 559 RINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFEN- 616
Query: 459 PSASYLEVTPDSEN-DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE-PYSSTAQ 516
L++T + D G Y C+ + + + + V P P I E P +S Q
Sbjct: 617 ---GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP--PLIQPFEFPPASIGQ 671
Query: 517 VQFDE-PEATGGVPILKYKAEWRAVGEEV 544
+ + ++G +PI + WR G+ +
Sbjct: 672 LLYIPCVVSSGDMPI---RITWRKDGQVI 697
Score = 67.4 bits (163), Expect = 5e-11
Identities = 75/307 (24%), Positives = 125/307 (40%), Gaps = 51/307 (16%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
+ V L C + GDP P++ W + + S+ ++DGH ++ ++ +L L++++ D+G
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSED-SAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGY 1420
Query: 383 YICTASNTIGQDSQSMYLEVQYAP--------KLQGPVAVYTW---EGNQVNITCEVFAY 431
Y CTA+NT G D+ + L VQ P K TW + +I V Y
Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY 1480
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
++D + SS+ + K+ + ++ +V ++N G+ RI +
Sbjct: 1481 SVDNSEEWKD--VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS------GRISE---- 1528
Query: 492 FILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKYKAEWRAV 540
+++A T EP S Q F +T GG PI E+R
Sbjct: 1529 --IIEAKTHGR------EPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPK 1580
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
G W A+ G V + L+ T Y +R+ A N G G +A +
Sbjct: 1581 GTWAW-----QGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGST 1635
Query: 601 PPPPASA 607
PP SA
Sbjct: 1636 IPPIKSA 1642
Score = 56.2 bits (134), Expect = 1e-07
Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 33/298 (11%)
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSW-TKDGEQIEQEEDDEKYIFSDDSSQLTIKKV 277
++ T + V + C A G P + W G+ I + +++ ++ + QL
Sbjct: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDI-YDVPHIRHVHANGTLQLYPFSP 149
Query: 278 DKND----EAEYICIAENKAGE-QDATIHLK-VFAKPKITYVENQTAMELEEQV--TLTC 329
+ + +Y C AEN AG+ + I +K VF +P VE+Q +M V L
Sbjct: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIP 209
Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA-GEYIC-TA 387
+ + + ++W T +I E + + H L + +Q DA Y C T
Sbjct: 210 SSVQEYVSVVSWEKDTVSIIPEHR-----FFITYH---GGLYISDVQKEDALSTYRCITK 261
Query: 388 SNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440
G+ QS + L G + W G+ V + C YP I W +
Sbjct: 262 HKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK 321
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
DG+ LP+ + +I + L ++ D G Y C N G IL+ D
Sbjct: 322 DGRPLPADSRWTKRI------TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/213 (23%), Positives = 86/213 (40%), Gaps = 21/213 (9%)
Query: 392 GQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWFRDGQ- 443
G S+ + +E P + P + ++ G V + C P+ + W +D +
Sbjct: 1334 GNSSEKVTIE----PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED 1389
Query: 444 -LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502
+P S + I+ + V + D G Y CTA N G +++ L+ P
Sbjct: 1390 SAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYYTCTATNTGGFDTIIVNLLVQVPPDQ 1446
Query: 503 PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562
P + + +S+ + + P GG I + ++ E W + + E S +
Sbjct: 1447 PRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFK---- 1501
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
+ LK T Y V+LAA N G G IS E KT
Sbjct: 1502 LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKT 1534
Score = 44.3 bits (103), Expect = 4e-04
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 50/328 (15%)
Query: 208 VNVPPTIQARQNIVN----ATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ--IEQEEDDE 261
V + P +A I++ T + V L C++ G P P + WTKD E I D
Sbjct: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---KPKITYVENQTA 318
+ I ++ + L ++ V D Y C A N G ++L V +P++T + +
Sbjct: 1400 RLIHTNGT--LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSAS 1457
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+TLT + SI ++ + E+ D + + S R S L S++
Sbjct: 1458 -----SITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKD--VFISSSER--SFKLDSLKCG 1508
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQ---YAPKLQGPVAVYT-------------WEGNQV 422
+ A N++G S +E + P ++T W
Sbjct: 1509 TWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGC 1568
Query: 423 NITCEVFAY-PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
IT V Y P T +W Q L +++ + + A++ E+ + N G
Sbjct: 1569 PITAIVLEYRPKGTWAW----QGLRANSSGEVFLTELREATWYELRMRACNSAG------ 1618
Query: 482 VNRIGQESLEFILVQADTPSSPSIDQVE 509
G E+ +F + D + P I +
Sbjct: 1619 ---CGNETAQFATLDYDGSTIPPIKSAQ 1643
Score = 38.1 bits (87), Expect = 0.031
Identities = 24/88 (27%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 637 PSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVML 696
P P+L +SI + I D+GGS IR ++++Y +SE ++ + S L
Sbjct: 1444 PDQPRLTVSK-TSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKL 1502
Query: 697 KSLDWNAEYEVYVVAENQQGKSKAAHFV 724
SL Y+V + A+N G + + +
Sbjct: 1503 DSLKCGTWYKVKLAAKNSVGSGRISEII 1530
Score = 34.3 bits (77), Expect = 0.44
Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 8/103 (7%)
Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRD--VILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+D + C+ V P + W D + + D ++ +N L +R +K D G Y C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
G + + ++V VPP Q R + +A+ S+TL
Sbjct: 1425 A--TNTGGFDTIIVNLLVQVPPD-QPRLTVSKTSAS---SITL 1461
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 125 bits (315), Expect = 1e-28
Identities = 169/738 (22%), Positives = 276/738 (37%), Gaps = 105/738 (14%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
++WF G K+ P+ RI++ + L I DAG Y E E++ +
Sbjct: 223 VTWFR-EGHKIIPSN-RIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGENKTSPF 276
Query: 112 VKIFQKLMFKNAPTPQEFRE------GEDAVIV------CDVVSSLPP----TIIWKHKG 155
+ + + ++ TP+ G +V+ + ++S P ++ WK G
Sbjct: 277 IHLS---IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG 333
Query: 156 RDVI--LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPT 213
+ L R + +SN D G Y CE + + + + P
Sbjct: 334 VRITSGLHSFGRRLTISNP-------TSADTGPYVCEAALPGSAFEPARATAFLFIIEPP 386
Query: 214 IQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
+ +A + ++V + C A G P PT+ W KD I + ++ + + S L
Sbjct: 387 YFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA--SGGLR 444
Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPKITYVENQTAMELEEQVTLTCEAS 332
I+K+ D + C A N+ GE +L V P T T + L CE S
Sbjct: 445 IQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVS 504
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P+ITW+ ++S + M++ S L + + DAG Y C A+NT G
Sbjct: 505 GAPKPAITWKRENHILASGSVRIPRFMLLES----GGLQIAPVFIQDAGNYTCYAANTEG 560
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS--WFRDGQLLPSSN 449
+ S L V + P + +G + C P ++ W +D L S+
Sbjct: 561 SLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS 620
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE 509
S I + S L ++ D G+Y+C V+ G +S L + P SP V
Sbjct: 621 TSRIVVEKDGS---LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
Query: 510 PYSSTAQV-------QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562
P SS + FD G PIL Y E + W + M G VT
Sbjct: 678 PNSSHSHAVVLSWVRPFD-----GNSPILYYIVEL-SENNSPWKVHLSNVGP-EMTG-VT 729
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASE---FKTQPVHSPPPPASASSSTPVPLSPPD 619
+ GL P TY R+ A+N G G+ SA + +P +PP AS T +
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIM--- 786
Query: 620 TTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR--AL 677
W P + + +R Y++RYR L
Sbjct: 787 VQWQPP---------------------------------PETEHNGVLRGYILRYRLAGL 813
Query: 678 SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIP 735
E++ ++ ++ L +YE+ V A N G + V + Q PTA P
Sbjct: 814 PGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPP 873
Query: 736 ATLGGNSASYTFVSLLFS 753
+ + + T + L++
Sbjct: 874 QNVQTEAVNSTTIQFLWN 891
Score = 106 bits (264), Expect = 9e-23
Identities = 149/622 (23%), Positives = 244/622 (39%), Gaps = 65/622 (10%)
Query: 14 LGTAVSLQVDIVPSQGEISV--GESKFFLCQVAG--DAKDKDISWFSPNGEKLTPNQQRI 69
+GT ++ IV G SV G S+ L +A +D ++W NG ++T
Sbjct: 285 VGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW-KRNGVRITSGLHSF 343
Query: 70 SVVWNDDSSSTLTIYNANIDDAGIYKC--VVTGEDGSESEATVNVKIFQKLMFKNAPTPQ 127
LTI N D G Y C + G + AT + I + F P +
Sbjct: 344 G--------RRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESR 395
Query: 128 EFREGEDAV-IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
E E+ V I C + PT+ W + ++ R+ VL++ L+I+ ++ D G
Sbjct: 396 ISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGI 455
Query: 187 YRC----EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPE 242
++C EG GEI + N+ P R V+ T G + L C+ G P+
Sbjct: 456 FQCFASNEG-----GEIQTHTYLDVTNIAPVFTQRP--VDTTVTDGMTAILRCEVSGAPK 508
Query: 243 PTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHL 302
P ++W ++ + +S L I V D Y C A N G +A+ L
Sbjct: 509 PAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATL 568
Query: 303 KVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVR 362
V+ + I + + TL C A+ DP S+ + N++ + +V +
Sbjct: 569 TVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEK 628
Query: 363 SHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
SL + D G+Y C + G DS+ LEV P + V +
Sbjct: 629 D----GSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHS- 683
Query: 423 NITCEVFAYPSATISWFR--DGQ-------LLPSSNYSNIKIYNT---PSASYLEVTPDS 470
+ +SW R DG + S N S K++ + P + + V+ +
Sbjct: 684 ---------HAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLT 734
Query: 471 ENDFGNYNCTAVNRI--GQESLEF--ILVQADTPSSPSIDQVEP--YSSTAQVQFDEPEA 524
+ AVN + GQ S E +++ + PS+P + V + + VQ+ P
Sbjct: 735 PARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPE 794
Query: 525 TGGVPILK-YKAEWRAVGEEVWHSKWYDAKEASME-GIVTIVGLKPETTYAVRLAALNGK 582
T +L+ Y +R G ++ S E + L T Y +++AA NG
Sbjct: 795 TEHNGVLRGYILRYRLAG---LPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGA 851
Query: 583 GLGEIS-AASEFKTQPVHSPPP 603
GLG S A +E+ Q V + PP
Sbjct: 852 GLGVFSRAVTEYTLQGVPTAPP 873
Score = 105 bits (261), Expect = 2e-22
Identities = 104/415 (25%), Positives = 170/415 (40%), Gaps = 35/415 (8%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PT 148
DAG Y+CVV G+ + V++ F + + +G A++ ++S P P
Sbjct: 163 DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222
Query: 149 IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN-------- 200
+ W +G +I R + N L I +D G Y + GE
Sbjct: 223 VTWFREGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
Query: 201 -FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQE 257
+D+ + PTI + A ++ TL C A P + +++W ++G +I
Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSET-TLECIASARPVEDLSVTWKRNGVRITSG 339
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKIT-YV 313
+LTI D Y+C A + AT L + P T
Sbjct: 340 -------LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP 392
Query: 314 ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK 373
E++ + E+EE V + C+A G P+P++ W +IS + + V+ S L ++
Sbjct: 393 ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQN--PRYKVLAS----GGLRIQ 446
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431
++ D+G + C ASN G+ YL+V AP Q PV +G + CEV
Sbjct: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
P I+W R+ +L S + I + + L++ P D GNY C A N G
Sbjct: 507 PKPAITWKRENHILASGSV-RIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEG 560
Score = 40.8 bits (94), Expect = 0.005
Identities = 58/281 (20%), Positives = 103/281 (36%), Gaps = 62/281 (22%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G + L C AEG W +D ++ + KYI I + K D Y C
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI---------IPSLQKLDAGFYRC 169
Query: 288 IAENKAGEQDATIHLKVFAKPKITYV-------ENQTAMELEEQVTLTCEASGDPIPSIT 340
+ N+ G A + K ++ ++ Y+ + +T + + + P P +T
Sbjct: 170 VVRNRMG---ALLQRK--SEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVT 224
Query: 341 WRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYTDAGEYICTASN-TIGQDS 395
W +GH ++ S+ + L + + +DAG Y A N G++
Sbjct: 225 W------------FREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENK 272
Query: 396 QSMYLEVQYA-----PKLQGPVAVYTWEGN--------QVNITCEVFAYP--SATISWFR 440
S ++ + A P+ P V GN + + C A P +++W R
Sbjct: 273 TSPFIHLSIARDVGTPETMAPTIVVP-PGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+G + S +S L ++ + D G Y C A
Sbjct: 332 NGVRITSGLHS--------FGRRLTISNPTSADTGPYVCEA 364
Score = 37.7 bits (86), Expect = 0.040
Identities = 36/145 (24%), Positives = 61/145 (42%), Gaps = 11/145 (7%)
Query: 488 ESLEFILVQADTPSSPS------IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
E LE ++ + P+ + Q E + + ++Q+ P + G PI + + R +
Sbjct: 1462 EPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW-VPGSDGASPIRYFTMQVRELP 1520
Query: 542 EEVWHSKWYDAKEASMEGIVTIVG-LKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
W + + S E +V L+P T+Y +RL A N G + S+ +E T
Sbjct: 1521 RGEWQTY---SSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDV 1577
Query: 601 PPPPASASSSTPVPLSPPDTTWPLP 625
P P + S+TP S W P
Sbjct: 1578 PGEPPGSVSATPHTTSSVLIQWQPP 1602
Score = 35.8 bits (81), Expect = 0.15
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 1/103 (0%)
Query: 499 TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558
+P SP V +S +Q+ E + G P Y E R E +W D ++
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEGHS-GDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960
Query: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSP 601
+++ L+ TY R+ A+N G GE S S + V +P
Sbjct: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
Score = 34.3 bits (77), Expect = 0.44
Identities = 36/171 (21%), Positives = 60/171 (35%), Gaps = 38/171 (22%)
Query: 513 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 572
++ ++ + PE G+ IL Y+ +R + + T L PE+ Y
Sbjct: 1392 TSVRIVWQPPEEPNGI-ILGYQIAYRLASSSPHTFTTVEVGATVRQ--FTATDLAPESAY 1448
Query: 573 AVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATTEP 632
RL+A +G GE A+ T+ P PP
Sbjct: 1449 IFRLSAKTRQGWGEPLEATVITTEKRERPAPPREL------------------------- 1483
Query: 633 AKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL-SSEWK 682
L Q S+++ + DG SPIR++ ++ R L EW+
Sbjct: 1484 ---------LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQ 1525
Score = 32.7 bits (73), Expect = 1.3
Identities = 28/130 (21%), Positives = 55/130 (42%), Gaps = 11/130 (8%)
Query: 491 EFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE---VWH 546
+ + Q D P + + E ++ +V + EP G+ I Y+ W G + H
Sbjct: 963 QLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGI-ITGYQISWEVYGRNDSRLTH 1021
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPAS 606
+ E ++G+ ++ TTY + +AA+ G G +++++ P P P++
Sbjct: 1022 TLNSTTHEYKIQGLSSL------TTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN 1075
Query: 607 ASSSTPVPLS 616
S P S
Sbjct: 1076 LVISNISPRS 1085
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,773,998
Number of Sequences: 37866
Number of extensions: 1529468
Number of successful extensions: 17362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 301
Number of HSP's successfully gapped in prelim test: 380
Number of HSP's that attempted gapping in prelim test: 8103
Number of HSP's gapped (non-prelim): 4639
length of query: 761
length of database: 18,247,518
effective HSP length: 110
effective length of query: 651
effective length of database: 14,082,258
effective search space: 9167549958
effective search space used: 9167549958
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.