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Search of human proteins with 231569235
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
(207 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] 424 e-119
gi|33598916 claudin 10 isoform a [Homo sapiens] 412 e-116
gi|5921465 claudin 10 isoform b [Homo sapiens] 332 1e-91
gi|7656981 claudin 15 [Homo sapiens] 138 3e-33
gi|183979973 claudin 19 isoform a [Homo sapiens] 135 2e-32
gi|183979975 claudin 19 isoform b [Homo sapiens] 135 2e-32
gi|153792186 claudin 7 [Homo sapiens] 129 2e-30
gi|50345279 claudin 18 isoform 2 [Homo sapiens] 114 6e-26
gi|40788011 claudin 8 [Homo sapiens] 113 1e-25
gi|10863887 claudin 1 [Homo sapiens] 112 3e-25
gi|7705961 claudin 18 isoform 1 [Homo sapiens] 110 8e-25
gi|4502875 claudin 3 [Homo sapiens] 108 3e-24
gi|195947374 claudin 5 [Homo sapiens] 105 2e-23
gi|195947372 claudin 5 [Homo sapiens] 105 2e-23
gi|4502877 claudin 4 [Homo sapiens] 100 9e-22
gi|6912316 claudin 17 [Homo sapiens] 99 3e-21
gi|225703142 claudin 14 [Homo sapiens] 94 1e-19
gi|21536294 claudin 14 [Homo sapiens] 94 1e-19
gi|153792768 claudin 6 [Homo sapiens] 94 1e-19
gi|225703138 claudin 14 [Homo sapiens] 94 1e-19
gi|6912314 claudin 14 [Homo sapiens] 94 1e-19
gi|225703140 claudin 14 [Homo sapiens] 94 1e-19
gi|47716519 claudin 20 [Homo sapiens] 94 1e-19
gi|11141861 claudin 9 [Homo sapiens] 92 4e-19
gi|9966781 claudin 2 [Homo sapiens] 89 2e-18
gi|10938016 claudin 11 [Homo sapiens] 70 1e-12
gi|162417973 claudin 22 [Homo sapiens] 64 9e-11
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 64 1e-10
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 64 1e-10
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 64 1e-10
>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
Length = 207
Score = 424 bits (1090), Expect = e-119
Identities = 207/207 (100%), Positives = 207/207 (100%)
Query: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGYIQACRG 60
MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGYIQACRG
Sbjct: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGYIQACRG 60
Query: 61 LMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANK 120
LMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANK
Sbjct: 61 LMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANK 120
Query: 121 ITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVM 180
ITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVM
Sbjct: 121 ITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVM 180
Query: 181 SSRTKYHGGEDFKTTNPSKQFDKNAYV 207
SSRTKYHGGEDFKTTNPSKQFDKNAYV
Sbjct: 181 SSRTKYHGGEDFKTTNPSKQFDKNAYV 207
>gi|33598916 claudin 10 isoform a [Homo sapiens]
Length = 226
Score = 412 bits (1060), Expect = e-116
Identities = 207/226 (91%), Positives = 207/226 (91%), Gaps = 19/226 (8%)
Query: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAG------- 53
MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAG
Sbjct: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH 60
Query: 54 ------------YIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 101
YIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI
Sbjct: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 120
Query: 102 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 161
VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS
Sbjct: 121 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 180
Query: 162 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 207
ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV
Sbjct: 181 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226
>gi|5921465 claudin 10 isoform b [Homo sapiens]
Length = 228
Score = 332 bits (851), Expect = 1e-91
Identities = 168/223 (75%), Positives = 180/223 (80%), Gaps = 19/223 (8%)
Query: 4 AQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCA----------- 52
++I A + + G+ + + ++ WKV+T +VIT + LW C
Sbjct: 6 SEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKD 65
Query: 53 --------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI
Sbjct: 66 FPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 125
Query: 105 LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD
Sbjct: 126 LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD 185
Query: 165 NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 207
NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV
Sbjct: 186 NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 228
>gi|7656981 claudin 15 [Homo sapiens]
Length = 228
Score = 138 bits (348), Expect = 3e-33
Identities = 80/218 (36%), Positives = 117/218 (53%), Gaps = 32/218 (14%)
Query: 17 GALVAATT--SNEWKVTTRASSVITATWVYQGLWMNCA-------------------GYI 55
G L+ T ++ W+V+T +VIT +++ LW +CA GYI
Sbjct: 16 GLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSMLALSGYI 75
Query: 56 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA-KAKIACLAGIVFILSGLCSMTGC 114
QACR LMI A+ LGF G + + G++CT +GG + + KAK+A AG + IL+G+C M
Sbjct: 76 QACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAGICGMVAI 135
Query: 115 SLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCF-----SISDNNKTP 169
S YA IT +FFDPL+ KYELG AL++GW+ + + I+GG+ C S D +
Sbjct: 136 SWYAFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGGLCLCSACCCGSDEDPAASA 195
Query: 170 RYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 207
R Y SVM T G+ + ++ +NAYV
Sbjct: 196 RRPYQAPVSVMPVATSDQEGD-----SSFGKYGRNAYV 228
>gi|183979973 claudin 19 isoform a [Homo sapiens]
Length = 224
Score = 135 bits (341), Expect = 2e-32
Identities = 72/180 (40%), Positives = 106/180 (58%), Gaps = 22/180 (12%)
Query: 2 SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA-------- 52
S Q+ +GG+ ++A+T +WK ++ A ++ITA +Y+GLWM+CA
Sbjct: 4 SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
Query: 53 -----------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 100
G+IQ+ R LM+ AV LGF + ++ GMKCT+VG S+ AK ++A G
Sbjct: 64 CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
Query: 101 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 159
+FIL+GLC++T S YA +T EFF+P V +YE G ALF+GWA A L ++GG C
Sbjct: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183
>gi|183979975 claudin 19 isoform b [Homo sapiens]
Length = 211
Score = 135 bits (341), Expect = 2e-32
Identities = 72/180 (40%), Positives = 106/180 (58%), Gaps = 22/180 (12%)
Query: 2 SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA-------- 52
S Q+ +GG+ ++A+T +WK ++ A ++ITA +Y+GLWM+CA
Sbjct: 4 SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
Query: 53 -----------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 100
G+IQ+ R LM+ AV LGF + ++ GMKCT+VG S+ AK ++A G
Sbjct: 64 CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
Query: 101 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 159
+FIL+GLC++T S YA +T EFF+P V +YE G ALF+GWA A L ++GG C
Sbjct: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183
>gi|153792186 claudin 7 [Homo sapiens]
Length = 211
Score = 129 bits (323), Expect = 2e-30
Identities = 70/179 (39%), Positives = 103/179 (57%), Gaps = 22/179 (12%)
Query: 15 GFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNC-------------------AGY 54
G+ LVA T +W++++ A ++ITA +Y+GLWM+C +
Sbjct: 17 GWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAA 76
Query: 55 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA-KAKIACLAGIVFILSGLCSMTG 113
+QA R LM+ ++ LGF A GMKCT+ GG DK KA+IA GI+FI++GL ++
Sbjct: 77 LQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVA 136
Query: 114 CSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY 171
CS Y ++I T+F++PL KYE G A+FIGWAG++L I+GG + S N Y
Sbjct: 137 CSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGY 195
>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
Length = 261
Score = 114 bits (285), Expect = 6e-26
Identities = 77/241 (31%), Positives = 114/241 (47%), Gaps = 56/241 (23%)
Query: 15 GFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCA----------GY---------I 55
G ++AAT ++W ++ +TA + YQGLW +C GY +
Sbjct: 17 GIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAML 76
Query: 56 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFILSGLCSMTGC 114
QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI+SGLC++ G
Sbjct: 77 QAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGV 136
Query: 115 SLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCIIGGVIFCFSI 162
S++AN + T F+ V+ +Y GAALF+GW L +IGGV+ C +
Sbjct: 137 SVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIAC 196
Query: 163 ------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG---EDFKTTNPS 198
N K Y +G A++ S TK Y GG ED + PS
Sbjct: 197 RGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPS 256
Query: 199 K 199
K
Sbjct: 257 K 257
>gi|40788011 claudin 8 [Homo sapiens]
Length = 225
Score = 113 bits (283), Expect = 1e-25
Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 24/214 (11%)
Query: 10 VSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY-------------- 54
+ GVG G VA T +W+V+ ++++ ++GLWMNC
Sbjct: 13 LGGVGMVGT-VAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLL 71
Query: 55 -----IQACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGL 108
+QA RGLM AA + F + A+ GMKCT+ G ++K KA I AGI+FI++G+
Sbjct: 72 ALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGM 131
Query: 109 CSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNK 167
+ S AN I +F++ + V QK ELG AL++GW A + I+GG +FC N K
Sbjct: 132 VVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEK 191
Query: 168 TPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQF 201
+ Y Y+ S +++ YH G+ + Q+
Sbjct: 192 SSSYRYS-IPSHRTTQKSYHTGKKSPSVYSRSQY 224
>gi|10863887 claudin 1 [Homo sapiens]
Length = 211
Score = 112 bits (279), Expect = 3e-25
Identities = 61/175 (34%), Positives = 96/175 (54%), Gaps = 23/175 (13%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGY------------- 54
+++ +G GA+V+ T +W++ + A +++TA +Y+GLWM+C
Sbjct: 12 ILAFLGWIGAIVS-TALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA-KAKIACLAGIVFILSG 107
+QA R LM+ + LG A GMKC K D+ K ++A + G +F+L+G
Sbjct: 71 LNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAG 130
Query: 108 LCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFS 161
L + + Y N+I EF+DP+ V +YE G ALF GWA ASLC++GG + C S
Sbjct: 131 LAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCS 185
>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
Length = 261
Score = 110 bits (275), Expect = 8e-25
Identities = 75/251 (29%), Positives = 114/251 (45%), Gaps = 56/251 (22%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCA------------ 52
Q+ A + + G +AAT + W + +T+ + Y+GLW +C
Sbjct: 7 QVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPY 66
Query: 53 -------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFI 104
+QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI
Sbjct: 67 FTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFI 126
Query: 105 LSGLCSMTGCSLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCI 152
+SGLC++ G S++AN + T F+ V+ +Y GAALF+GW L +
Sbjct: 127 VSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTL 186
Query: 153 IGGVIFCFSI------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG-- 189
IGGV+ C + N K Y +G A++ S TK Y GG
Sbjct: 187 IGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGAR 246
Query: 190 -EDFKTTNPSK 199
ED + PSK
Sbjct: 247 TEDEVQSYPSK 257
>gi|4502875 claudin 3 [Homo sapiens]
Length = 220
Score = 108 bits (270), Expect = 3e-24
Identities = 68/197 (34%), Positives = 105/197 (53%), Gaps = 27/197 (13%)
Query: 13 VGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGY----------------- 54
+G G +V W+V+ S++IT+ +++GLWMNC
Sbjct: 15 LGWLGTIVCCALPM-WRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALP 73
Query: 55 --IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMT 112
+QA R L++ A+ L FG + AL G +CT D AKAKI +AG++F+L+ L ++
Sbjct: 74 QDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLV 133
Query: 113 GCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY 171
S AN I +F++P+ E QK E+GA L++GWA A+L ++GG + C S K +Y
Sbjct: 134 PVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREK--KY 191
Query: 172 TYNGATSVMSSRTKYHG 188
T AT V+ S + G
Sbjct: 192 T---ATKVVYSAPRSTG 205
>gi|195947374 claudin 5 [Homo sapiens]
Length = 303
Score = 105 bits (263), Expect = 2e-23
Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 21/176 (11%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA----GY----- 54
+I LV + G+G L+ A W+VT +++TA ++GLWM+C G+
Sbjct: 92 EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
+QA R L ++AV L F L G +CT AKA++A G++++
Sbjct: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211
Query: 105 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 159
GL ++ +AN + EF+DP + V QKYELGAAL+IGWA +L ++GG + C
Sbjct: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267
>gi|195947372 claudin 5 [Homo sapiens]
Length = 303
Score = 105 bits (263), Expect = 2e-23
Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 21/176 (11%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA----GY----- 54
+I LV + G+G L+ A W+VT +++TA ++GLWM+C G+
Sbjct: 92 EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
+QA R L ++AV L F L G +CT AKA++A G++++
Sbjct: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211
Query: 105 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 159
GL ++ +AN + EF+DP + V QKYELGAAL+IGWA +L ++GG + C
Sbjct: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267
>gi|4502877 claudin 4 [Homo sapiens]
Length = 209
Score = 100 bits (249), Expect = 9e-22
Identities = 60/200 (30%), Positives = 102/200 (51%), Gaps = 22/200 (11%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGY--------- 54
Q+ + V G+ A++ W+VT S+++T+ +++GLWMNC
Sbjct: 7 QVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKV 66
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
+QA R L+I ++ + G + ++ G KCT + AKAK +AG+VF+
Sbjct: 67 YDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFL 126
Query: 105 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 163
L+GL + S A+ I +F++PL QK E+GA+L++GWA + L ++GG + C +
Sbjct: 127 LAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCP 186
Query: 164 DNNKTP-RYTYNGATSVMSS 182
P Y+ A S +S
Sbjct: 187 PRTDKPYSAKYSAARSAAAS 206
>gi|6912316 claudin 17 [Homo sapiens]
Length = 224
Score = 98.6 bits (244), Expect = 3e-21
Identities = 65/193 (33%), Positives = 98/193 (50%), Gaps = 26/193 (13%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY--------- 54
QI LV G G +A T +W+V+ S++I +++GLWMNC
Sbjct: 7 QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKF 66
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMK---CTKVGGSDKAKAKIACLAGI 101
++ R LM AV+L + + GMK CT G +++AKA + +G+
Sbjct: 67 YSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYLLGTSGV 124
Query: 102 VFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFCF 160
+FIL+G+ + S AN I +F++P + + QK ELGAALF+GWA A++ IGG + C
Sbjct: 125 LFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCG 184
Query: 161 SISDNNKTPRYTY 173
N K Y Y
Sbjct: 185 FCCCNRKKQGYRY 197
>gi|225703142 claudin 14 [Homo sapiens]
Length = 239
Score = 93.6 bits (231), Expect = 1e-19
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 22/177 (12%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY------------- 54
L+S +G G L+ T W+ T ++++TA +GLWM C +
Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 108
+QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL
Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130
Query: 109 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D
Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187
>gi|21536294 claudin 14 [Homo sapiens]
Length = 239
Score = 93.6 bits (231), Expect = 1e-19
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 22/177 (12%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY------------- 54
L+S +G G L+ T W+ T ++++TA +GLWM C +
Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 108
+QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL
Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130
Query: 109 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D
Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187
>gi|153792768 claudin 6 [Homo sapiens]
Length = 220
Score = 93.6 bits (231), Expect = 1e-19
Identities = 52/153 (33%), Positives = 83/153 (54%), Gaps = 21/153 (13%)
Query: 28 WKVTTR-ASSVITATWVYQGLWMNCAGY-------------------IQACRGLMIAAVS 67
WKVT +S++ A V++GLWM+C +QA R L + A+
Sbjct: 30 WKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALL 89
Query: 68 LGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD 127
+ FG + L G KCT +KA++ +GIVF++SG+ ++ A+ I +F++
Sbjct: 90 VALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYN 149
Query: 128 PLFVE-QKYELGAALFIGWAGASLCIIGGVIFC 159
PL E QK ELGA+L++GWA + L ++GG + C
Sbjct: 150 PLVAEAQKRELGASLYLGWAASGLLLLGGGLLC 182
>gi|225703138 claudin 14 [Homo sapiens]
Length = 239
Score = 93.6 bits (231), Expect = 1e-19
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 22/177 (12%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY------------- 54
L+S +G G L+ T W+ T ++++TA +GLWM C +
Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 108
+QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL
Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130
Query: 109 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D
Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187
>gi|6912314 claudin 14 [Homo sapiens]
Length = 239
Score = 93.6 bits (231), Expect = 1e-19
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 22/177 (12%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY------------- 54
L+S +G G L+ T W+ T ++++TA +GLWM C +
Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 108
+QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL
Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130
Query: 109 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D
Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187
>gi|225703140 claudin 14 [Homo sapiens]
Length = 239
Score = 93.6 bits (231), Expect = 1e-19
Identities = 57/177 (32%), Positives = 85/177 (48%), Gaps = 22/177 (12%)
Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY------------- 54
L+S +G G L+ T W+ T ++++TA +GLWM C +
Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70
Query: 55 ------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 108
+QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL
Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130
Query: 109 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 164
M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D
Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187
>gi|47716519 claudin 20 [Homo sapiens]
Length = 219
Score = 93.6 bits (231), Expect = 1e-19
Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 21/187 (11%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY--------- 54
Q+ A + + G ++ AT WKV S++ITA GLWM+C Y
Sbjct: 7 QLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTGMFSCAL 66
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
+QA R M+ A L G + GMKCT++GG + K+ + G+ F+
Sbjct: 67 KHSILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGGDRETKSHASFAGGVCFM 126
Query: 105 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 163
+G+ S+ Y +I F D E K+E G A++IG+ A L I G+IFC S
Sbjct: 127 SAGISSLISTVWYTKEIIANFLDLTVPESNKHEPGGAIYIGFISAMLLFISGMIFCTSCI 186
Query: 164 DNNKTPR 170
N R
Sbjct: 187 KRNPEAR 193
>gi|11141861 claudin 9 [Homo sapiens]
Length = 217
Score = 91.7 bits (226), Expect = 4e-19
Identities = 55/168 (32%), Positives = 88/168 (52%), Gaps = 22/168 (13%)
Query: 13 VGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGY----------------- 54
+G G LV+ WKVT +S++ A V++GLWM+C
Sbjct: 16 LGWLGTLVSCALPL-WKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALP 74
Query: 55 --IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMT 112
+QA R L + A+ L G + A+ G +CT + AKA+I AG++ +L+G+ +
Sbjct: 75 QDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLI 134
Query: 113 GCSLYANKITTEFFDPLFVEQ-KYELGAALFIGWAGASLCIIGGVIFC 159
A+ I +F++PL E K ELGA+L++GWA A+L ++GG + C
Sbjct: 135 PVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLC 182
>gi|9966781 claudin 2 [Homo sapiens]
Length = 230
Score = 89.4 bits (220), Expect = 2e-18
Identities = 56/224 (25%), Positives = 99/224 (44%), Gaps = 21/224 (9%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY--------- 54
Q+ + G+ G + A WK ++ +S++TA +GLWM CA +
Sbjct: 7 QLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDI 66
Query: 55 ----------IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 104
IQA + +M+ + ++ I ++ GM+CT +AK ++A G+ FI
Sbjct: 67 YSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFI 126
Query: 105 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 163
L GL + + I +F+ PL + K+E+G AL++G + +I G+I CFS S
Sbjct: 127 LGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCS 186
Query: 164 DNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 207
Y +++R+ G+ K + + YV
Sbjct: 187 SQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV 230
>gi|10938016 claudin 11 [Homo sapiens]
Length = 207
Score = 70.1 bits (170), Expect = 1e-12
Identities = 55/182 (30%), Positives = 85/182 (46%), Gaps = 38/182 (20%)
Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQ----GLWMNCA-------- 52
Q+ V+ G+ ++ T++N+W VT ++ T + + GLW +C
Sbjct: 7 QVVGFVTSFVGWIGVIVTTSTNDWVVTC-GYTIPTCRKLDELGSKGLWADCVMATGLYHC 65
Query: 53 ----------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGS-DKAKAKIACLAGI 101
GY+QACR LMIAA LG + L + C ++G AK + A LAG+
Sbjct: 66 KPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGV 125
Query: 102 VFILSGLCSMTGCSLY---ANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGG-VI 157
+ IL LC++ + A++ TT G +L+ GW GA LC++GG VI
Sbjct: 126 LLILLALCALVATIWFPVCAHRETT----------IVSFGYSLYAGWIGAVLCLVGGCVI 175
Query: 158 FC 159
C
Sbjct: 176 LC 177
>gi|162417973 claudin 22 [Homo sapiens]
Length = 220
Score = 63.9 bits (154), Expect = 9e-11
Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 6/116 (5%)
Query: 55 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAGIVFILSGLCSMTG 113
++ R LM + LGF G + + FG+ C ++G S + K ++ L GI+ SG+ ++
Sbjct: 77 LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILSWASGVTALVP 136
Query: 114 CSLYANKITTEFFD---PLFVEQKYELGAALFIGW-AGASLCIIGGVIFCFSISDN 165
S A+K EF+D P FV ++E G ALF+GW AG SL + G ++ C + S +
Sbjct: 137 VSWVAHKTVQEFWDENVPDFV-PRWEFGEALFLGWFAGLSLLLGGCLLHCAACSSH 191
>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 63.5 bits (153), Expect = 1e-10
Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 6/116 (5%)
Query: 55 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAGIVFILSGLCSMTG 113
++ R LM + LGF G + + FG+ C ++G S + K ++ L GI+ SG+ ++
Sbjct: 77 LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILSWASGITALVP 136
Query: 114 CSLYANKITTEFFD---PLFVEQKYELGAALFIGW-AGASLCIIGGVIFCFSISDN 165
S A+K EF+D P FV ++E G ALF+GW AG SL + G ++ C + S +
Sbjct: 137 VSWVAHKTVQEFWDENVPDFV-PRWEFGEALFLGWFAGLSLLLGGCLLNCAACSSH 191
>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 63.5 bits (153), Expect = 1e-10
Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 6/116 (5%)
Query: 55 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAGIVFILSGLCSMTG 113
++ R LM + LGF G + + FG+ C ++G S + K ++ L GI+ SG+ ++
Sbjct: 77 LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILSWASGITALVP 136
Query: 114 CSLYANKITTEFFD---PLFVEQKYELGAALFIGW-AGASLCIIGGVIFCFSISDN 165
S A+K EF+D P FV ++E G ALF+GW AG SL + G ++ C + S +
Sbjct: 137 VSWVAHKTVQEFWDENVPDFV-PRWEFGEALFLGWFAGLSLLLGGCLLNCAACSSH 191
>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 63.5 bits (153), Expect = 1e-10
Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 6/116 (5%)
Query: 55 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAGIVFILSGLCSMTG 113
++ R LM + LGF G + + FG+ C ++G S + K ++ L GI+ SG+ ++
Sbjct: 77 LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILSWASGITALVP 136
Query: 114 CSLYANKITTEFFD---PLFVEQKYELGAALFIGW-AGASLCIIGGVIFCFSISDN 165
S A+K EF+D P FV ++E G ALF+GW AG SL + G ++ C + S +
Sbjct: 137 VSWVAHKTVQEFWDENVPDFV-PRWEFGEALFLGWFAGLSLLLGGCLLNCAACSSH 191
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,097,031
Number of Sequences: 37866
Number of extensions: 265025
Number of successful extensions: 852
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 741
Number of HSP's gapped (non-prelim): 62
length of query: 207
length of database: 18,247,518
effective HSP length: 98
effective length of query: 109
effective length of database: 14,536,650
effective search space: 1584494850
effective search space used: 1584494850
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.