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Search of human proteins with 229892306
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens]
(1265 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens] 2507 0.0
gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens] 2498 0.0
gi|229892308 shugoshin-like 2 isoform 2 [Homo sapiens] 2398 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 74 9e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 70 1e-11
gi|71061468 centromere protein E [Homo sapiens] 69 2e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 67 8e-11
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 67 1e-10
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 67 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 62 3e-09
gi|87299628 biorientation of chromosomes in cell division 1-like... 61 6e-09
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 61 6e-09
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 60 1e-08
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 60 1e-08
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 59 2e-08
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 59 2e-08
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 58 7e-08
gi|38044112 restin isoform b [Homo sapiens] 57 9e-08
gi|4506751 restin isoform a [Homo sapiens] 57 9e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 55 4e-07
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 54 7e-07
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 54 7e-07
gi|9910266 kinesin family member 15 [Homo sapiens] 54 7e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 54 9e-07
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 53 2e-06
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 52 4e-06
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 52 5e-06
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 51 6e-06
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 51 8e-06
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 50 1e-05
>gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens]
Length = 1265
Score = 2507 bits (6498), Expect = 0.0
Identities = 1265/1265 (100%), Positives = 1265/1265 (100%)
Query: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
Sbjct: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
Query: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
Sbjct: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
Query: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
Sbjct: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
Query: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
Sbjct: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
Query: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
Sbjct: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
Query: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
Sbjct: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
Query: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
Sbjct: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
Query: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
Sbjct: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
Query: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
Sbjct: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
Query: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
Sbjct: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
Sbjct: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
Sbjct: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
Query: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
Sbjct: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
Query: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
Sbjct: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
Query: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
Sbjct: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
Query: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
Sbjct: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
Query: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
Sbjct: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
Query: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
Sbjct: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
Sbjct: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
Query: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
Sbjct: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
Query: 1201 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1260
VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
Sbjct: 1201 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1260
Query: 1261 DKMRR 1265
DKMRR
Sbjct: 1261 DKMRR 1265
>gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens]
Length = 1261
Score = 2498 bits (6474), Expect = 0.0
Identities = 1260/1261 (99%), Positives = 1261/1261 (100%)
Query: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
Sbjct: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
Query: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
Sbjct: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
Query: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
Sbjct: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
Query: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
Sbjct: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
Query: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
Sbjct: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
Query: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
Sbjct: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
Query: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
Sbjct: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
Query: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
Sbjct: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
Query: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
Sbjct: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
Query: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
Sbjct: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
Sbjct: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
Sbjct: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
Query: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
Sbjct: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
Query: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
Sbjct: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
Query: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
Sbjct: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
Query: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
Sbjct: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
Query: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
Sbjct: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
Query: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
Sbjct: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
Sbjct: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
Query: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
Sbjct: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
Query: 1201 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1260
VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
Sbjct: 1201 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR 1260
Query: 1261 D 1261
+
Sbjct: 1261 E 1261
>gi|229892308 shugoshin-like 2 isoform 2 [Homo sapiens]
Length = 1260
Score = 2398 bits (6214), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
Sbjct: 1 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA 60
Query: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
Sbjct: 61 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT 120
Query: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
Sbjct: 121 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI 180
Query: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
Sbjct: 181 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS 240
Query: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
Sbjct: 241 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI 300
Query: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
Sbjct: 301 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV 360
Query: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
Sbjct: 361 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS 420
Query: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
Sbjct: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE 480
Query: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
Sbjct: 481 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI 540
Query: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
Sbjct: 541 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
Sbjct: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
Sbjct: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
Query: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
Sbjct: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
Query: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
Sbjct: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
Query: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
Sbjct: 841 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE 900
Query: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
Sbjct: 901 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK 960
Query: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
Sbjct: 961 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE 1020
Query: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
Sbjct: 1021 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
Sbjct: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS 1140
Query: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
Sbjct: 1141 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
Query: 1201 VNRRTQKSGI 1210
VNRRTQKSGI
Sbjct: 1201 VNRRTQKSGI 1210
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 73.9 bits (180), Expect = 9e-13
Identities = 197/969 (20%), Positives = 383/969 (39%), Gaps = 159/969 (16%)
Query: 316 NETNTE-MQRNKQDLPGL----SSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTAS 370
N+T TE + + +QD L + ES + N + +D D QLQ L+AS
Sbjct: 304 NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSR-------LSAS 356
Query: 371 EVS-KIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKI 429
E S + V K ++ +K E + K + +E K+ + +R+ K + + +I
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416
Query: 430 EN------RTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGD 483
TER L G ++E+L +Q+A + +LK L+ ++
Sbjct: 417 NQLHSKLLETERQ--LGEAHGRLKEQRQLSSEKLMDKEQQVADL-QLKLSRLEEQLKEKV 473
Query: 484 RENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKL 543
+ + + + +E +L QS+ +K + QN L + + I L
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQST-----TAKLREAQNDLEQVLRQIGDKDQKIQNL 528
Query: 544 E------KDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVT 597
E K+N+ +K++ +Y + E TA L+ N H L++ VT
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQA-GEGETAVLNQLQEKN------HT---LQEQVT 578
Query: 598 DIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPI 657
+ +N+S +K ++ N ++ H+ D+ + + E KE +
Sbjct: 579 QLTEKLKNQSESHKQAQE-NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 658 SE---NIEVSKELQIPALSTR-----DNENQCDYRTQNVLGLQKQITNMYPVQQNESKVN 709
S+ I+ EL + A + + D +N D QN L ++Q N Q ++ V
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD-TAQNALQDKQQELNKITTQLDQ--VT 694
Query: 710 KKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPAL 769
KL+ K +++ S + EY K L L QK +E+ G ++ + E +L
Sbjct: 695 AKLQDKQEHCSQLESHLK--------EY--KEKYLSLEQKTEEL-EGQIK---KLEADSL 740
Query: 770 STKDSGN--LYDSEIQNVLGVK---HGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQ 824
K S L D + Q L ++ + + +I RL++ +KSE + Q
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 825 IYENDNKGVHDLEKDNFFSLTPKDK---ETISENLQVT---------------NEFQTV- 865
+ L++D F +L+ + K E ++ +Q T E TV
Sbjct: 801 KLTKQEEEKQILKQD-FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 866 DLLIKDNGNL----CDYDTQN------ILELKKYVTD-------------------RKSA 896
D L K + +L +++ +N IL+L+K + +KS
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 897 EQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQD 956
E+ + ++L+ ++N E + + + N+K+ + L +N+ KQ E
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE-------EQQLQGNINELKQSSE--- 969
Query: 957 IINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTS 1016
+K+ + + K+ +K E K + LT+A +LA++ + S
Sbjct: 970 -----------QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 1017 ISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMT 1076
+ E + G EL T++ + K L E++ Q+ NK+
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA-QEDLISNRNQIGNQNKLI 1077
Query: 1077 SKSKKRKTSI--DPSPESHEVMER--ILDSVQGKSTVSEQADKENNLENEK-MVKNKPDF 1131
+ K K ++ D + + ++ ER L +Q E++ KE L NEK + +
Sbjct: 1078 QELKTAKATLEQDSAKKEQQLQERCKALQDIQ-----KEKSLKEKELVNEKSKLAEIEEI 1132
Query: 1132 YTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEH 1191
+ + +++++ ++ +S++E ++ K ++I++ L+ + E
Sbjct: 1133 KCRQEKEITKLNE-ELKSHKLESIKE---ITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 1192 EKMNKMKFK 1200
EK N+ K
Sbjct: 1189 EKRNQQILK 1197
Score = 40.0 bits (92), Expect = 0.014
Identities = 173/993 (17%), Positives = 380/993 (38%), Gaps = 198/993 (19%)
Query: 37 SKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFL 96
+++ K+ N S S K L + +K + R + L+ V +LN +
Sbjct: 578 TQLTEKLKNQSE----SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 97 RLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPF 156
+ K++ L DI+ L+ + E + ++ L ++ KQ +L ++
Sbjct: 634 KEKVSQL-----DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 157 ARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQ------DNSEVLFLK 210
+T+ +D+ + Q ++++K + S T+ L Q D+ EV K
Sbjct: 689 QLDQVTAKL-QDKQEHCSQLESHLKEYKEKYL-SLEQKTEELEGQIKKLEADSLEVKASK 746
Query: 211 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQ------SSKTSLMSEMRNAQSIGRRWEK 264
E Q + L +++ +++ E + S++ L + +SI ++ K
Sbjct: 747 E--QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 265 PSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQR 324
E +K+ + LS +T QH E+N T TE+Q+
Sbjct: 805 Q------EEEKQILKQDFETLSQETKI------QH---------EELNNRIQTTVTELQK 843
Query: 325 NKQDLPGLSSE--SAREPNAECMNQIEDN-DDFQLQKTVYDA---DMDLTASEVSKIVTV 378
K + L +E + ++ ++ + ++++ +F+ + A D++ T E+ + V
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 379 STGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDV 438
K K+ K+ K K++S + K E + Q E + +
Sbjct: 904 QMENTLKEQKELK----KSLEKEKEASHQLKLELNSMQ-------------EQLIQAQNT 946
Query: 439 LDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
L E +QL +L Q +E KK ++ QG+ + + K E
Sbjct: 947 LKQNEKEE--------QQLQGNINELKQSSEQKKKQIEA--LQGELKIAVLQKTELENKL 996
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKD------NLLPNQ 552
+Q+ T + QE +K + S+ N + S++TF +L+ D LL +
Sbjct: 997 QQQLTQAA--------QELAAEKEKISVLQNNYEKSQETF--KQLQSDFYGRESELLATR 1046
Query: 553 KDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQN-ESNINK 611
+D ++ E L + E +N + N N K + +++ ++ E + K
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQN-------------KLIQELKTAKATLEQDSAK 1093
Query: 612 LRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPA 671
+++ + + + + +K++V+ ++ K E I+ +E +I
Sbjct: 1094 KEQQLQERCKALQDIQKEKSLKEKELVN-----------EKSKLAEIEEIKCRQEKEI-- 1140
Query: 672 LSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDN 731
T+ NE ++ +++ K+ITN+ +Q + +K E+ + + L
Sbjct: 1141 --TKLNEELKSHKLESI----KEITNLKDAKQ----------LLIQQKLELQGKADSL-- 1182
Query: 732 DKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHG 791
++E ++ + Q KE E E + L+ + +G+K
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKE----------EEELKKEFIEKEAKLHSEIKEKEVGMKK- 1231
Query: 792 HDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKET 851
H+ +N++K+ + + +E + + +++ + V +LEK
Sbjct: 1232 HE-----ENEAKL----TMQITALNENLGTVKKEWQSSQRRVSELEK------------- 1269
Query: 852 ISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVN 911
+ + E ++ +++N D + L L++ + E+ ++K+ +L+ K++
Sbjct: 1270 --QTDDLRGEIAVLEATVQNN-----QDERRAL-LERCLKGEGEIEKLQTKVLELQRKLD 1321
Query: 912 WKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKE 971
T + E+ + ++ +Q +T+ L+ K + + C + V +
Sbjct: 1322 NTTAAVQELGR------ENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCR 1375
Query: 972 SCDQILDSYKVVKKRKKESSCKAKNILTKAKNK 1004
C I + C AKN LT + K
Sbjct: 1376 QCGNIFC-----------AECSAKNALTPSSKK 1397
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 70.1 bits (170), Expect = 1e-11
Identities = 226/1289 (17%), Positives = 496/1289 (38%), Gaps = 197/1289 (15%)
Query: 21 KDKRISKTTKLNVSLASKIKTKILNNSSIFKI--SLKHNNRALAQALSREKENSRRITTE 78
+ ++ + K N+ L +K+ + K L N L A + + S + E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 79 KMLLQKEVEKLNFENTFLRLKLNNL-NKKLIDIEALMNNNLITAIEMSSLS----EFHQS 133
+ + E L ++N L + +L+ +E + N +L +E + E + S
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE-MENQSLTKTVEELRTTVDSVEGNAS 491
Query: 134 SFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGS 193
L + +R+SK+ +++ ++ ++K+ +Q N+ + +
Sbjct: 492 KILKMEKENQRLSKKVEILE-----------NEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 194 TTQPLSTQDNSEVLFLKENN----QNVYGLDDSEHISS---IVDVPPRESHSHSDQSSKT 246
T + L ++ L++ N Q V L IS+ + D+ H +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 247 SLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELN 306
S +S++ +R K + E+ +R E N L +L K+ I++ ++
Sbjct: 601 SKLSKIE----FEKRQIKKELEHYKEKGERAEELE-NELHHLEKENELLQKK-ITNLKIT 654
Query: 307 CNN--EINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDAD 364
C + +E E ++ K+ L + + + + E N D ++ +L++ V
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES-- 712
Query: 365 MDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVD 424
L + + + +S K+ + G++ + +S KK ER + ++
Sbjct: 713 --LKCASMKMAQLQLENKELESEKEQLKKGLELLK-----ASFKKTERLEVSYQ------ 759
Query: 425 IGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDR 484
G IEN+ + + + +N+++ Q+ +L + E++ TLQ E+
Sbjct: 760 -GLDIENQRLQKTLEN------------SNKKIQQLESELQDL-EMENQTLQKNLEELKI 805
Query: 485 ENVLCNKKEKRITNEQEETYSLSQSSGKFHQESK----------------------FDKG 522
+ + EK + ++ET L + + +E+K +K
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 523 QNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLC 582
+L+ + +LEK+N ++ + I + + + + L T+ N
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 583 DYGTHNI----LDLKKYVTDIQPSEQN----ESNI-NKLRKKVNRKTEIISGMNHMYEDN 633
+ TH + L+ ++ + D Q ++ ES + + L+K + K E I+ + E++
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 634 DKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQ--------IPALSTRDN--ENQCDY 683
N+ + +++ + + +N E K+ Q P +S DN E +
Sbjct: 986 T----------NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1035
Query: 684 RTQNVLGLQKQI----TNMYPVQQNESKVNKKLRQ-------------KVNRKTEIISEV 726
T+ +L ++ ++ N +Q + + +L+Q + R+T + E
Sbjct: 1036 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
Query: 727 NHLDNDKSIEY-----TVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSE 781
N ++ + T+ S S L ++ +++ +E E+ +D +LYDS
Sbjct: 1096 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155
Query: 782 IQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKS------EIIPETNQIYENDNKGVHD 835
I++ ++ H+ Q A + +S I K L K+ ++ NQ+ + + + D
Sbjct: 1156 IKDHEKLELLHERQ-ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ-LED 1213
Query: 836 LEK-------------DNFFSLTPKDKETISENLQVTNEF----QTVDLLIKDNGNLCDY 878
LEK N ++ + K+ EN ++ + + + ++L D+ NL
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1273
Query: 879 DTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYT 938
+ LE + + ++ +++ K+N + E++S++ E+ ++ H+ +
Sbjct: 1274 LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR--HLLDQIQ 1331
Query: 939 KDLDFKVNKSKQKLECQDIIN---KHYM----EVNSNEKESCDQILDSYK---------- 981
+ +Q +E +D+ + + Y+ E+ +++ ++I+D YK
Sbjct: 1332 TLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391
Query: 982 ----VVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNP 1037
+K RK S K N + L ++SS+ + L +S S+
Sbjct: 1392 GNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1451
Query: 1038 VELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSI------DPSPE 1091
+ T+K S L K LPF+ + + ++K + + S+ S E
Sbjct: 1452 GQTLGTKKSSMVAL--KRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTE 1509
Query: 1092 SHEVMERILDSVQ----GKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNI 1147
+ EV + I + G S A + + + ++K K S +I +
Sbjct: 1510 NLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGV 1569
Query: 1148 QDSSFDSVR-EGLVPLSVSSGKNVIIKEN 1175
D S R P S+ SG+ N
Sbjct: 1570 SDDSSTGSRVHASRPASLDSGRTSTSNSN 1598
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 69.3 bits (168), Expect = 2e-11
Identities = 245/1335 (18%), Positives = 528/1335 (39%), Gaps = 206/1335 (15%)
Query: 26 SKTTKLNVSLASKIKTKILNNSSIF--------KISLKHNNRALAQALSREKENSRRITT 77
+KT KL+++L +I + + S +F +I + L Q + NS R
Sbjct: 448 TKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADY 507
Query: 78 EKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEAL-----MNNNLITAIEMSSLSEFHQ 132
+ ++L + E+L E + LKL N L + EAL + + E+S+L +
Sbjct: 508 DNLVL--DYEQLRTEKEEMELKLKEKND-LDEFEALERKTKKDQEMQLIHEISNLKNLVK 564
Query: 133 SSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSG 192
+ + + + +S + +L+R E ED+ K + I S+ L +I
Sbjct: 565 HAEVYNQDLENELSSKVELLR-------------EKEDQIK-KLQEYIDSQKLENIKMDL 610
Query: 193 STTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEM 252
S + S +D K+ Q ++ D+E ++ +D + S+ M E+
Sbjct: 611 SYSLE-SIEDP------KQMKQTLF---DAETVA--LDAKRESAFLRSENLELKEKMKEL 658
Query: 253 RNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSAD---TPCATVLDKQHISSPELNCNN 309
+ S + +KK E SA T +++D + +L CN
Sbjct: 659 ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNL 716
Query: 310 EINGHTNETNTEMQRNKQDLPGLSSESAREPNAECM-NQIEDNDDFQLQKTVYDA--DMD 366
E+ G + E+ + ++ L E + + +++E +L+K + D ++
Sbjct: 717 ELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVE-----RLRKEIQDKSEELH 771
Query: 367 LTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKN------- 419
+ SE K+ + + + E G S+ K ++ + FK
Sbjct: 772 IITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ 831
Query: 420 ------SSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQ----MNEQLAQVNE 469
+ + ++I N ++ + D GA + ++L + + E+L ++ +
Sbjct: 832 KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ 891
Query: 470 LKKM------TLQTGFEQGDRENVLCNKK-------EKRITNEQEETYSLSQSSGKFHQE 516
LK+ TLQT +RE L +K K +T E+++ L +S +
Sbjct: 892 LKEQLENRDSTLQTV----EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 517 SKFD----KGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVT----IYENLDVT-NE 567
K D N T + + + ++ H+ + L ++V+ + EN T +E
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 568 FHTA--------NLSTKDNGNL-CDYGTHNILDLKKYVTDI--QPSEQNESNINKLRKKV 616
F +L K+ L D + I++ ++ + + + +E + + + +K
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 617 NRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTR- 675
KT++ + E+ ++ + G + K Q++ +N + KE ++ R
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDE-----LKKQQEIVAQEKNHAIKKEGELSRTCDRL 1122
Query: 676 -DNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKS 734
+ E + ++Q + Q+Q+ N VQ+ S++ KK+ + N K E+ ++ L++
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLN---VQEEMSEMQKKINEIENLKNELKNKELTLEH--- 1176
Query: 735 IEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDM 794
+++ L L QK E N E+ K+ +++E ++ G + ++
Sbjct: 1177 ----METERLELAQKLNE----NYEEVKSITKERKVLKELQKSFETERDHLRG--YIREI 1226
Query: 795 QPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGV---HDLEKDNF---------- 841
+ + K +++ + E I E + + DLEK +
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 842 --FSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQN 899
L P KE +SE + NE + L+ + D T +E+++ + K E
Sbjct: 1287 EEQELLPNVKE-VSETQETMNELE----LLTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 900 ESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIIN 959
E + + + N KT I E ++ D K+ H++E+ K + +K +Q L ++ N
Sbjct: 1342 EEIKSLTKERDNLKT--IKEALEVKHDQLKE-HIRETLAK-IQESQSKQEQSLNMKEKDN 1397
Query: 960 KHYMEVNSNE----KESC------------DQILDSYKVVKK--RKKESSCKAKNILTKA 1001
+ V+ E K+S ++ +S+ +K ++K+ + + +L
Sbjct: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 1002 KNKLASQLTESSQTSISLESDLK--HITSEADSDPGNPVELCKTQKQSTTTLNKKDLPF- 1058
++L + E + E +LK H + + N + + ++K++ + +K L
Sbjct: 1458 SDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI 1517
Query: 1059 -------VEEI--KEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTV 1109
++EI KE + +K+++++ K + K E + + L S++ K
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK----QFKEHRKAKDSALQSIESKMLE 1573
Query: 1110 SEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKN 1169
+E+ E + M+K K + K + +I +D ++ +E + + S K
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEEM--KRVQEALQIE----RDQLKENTKEIVAKMKESQEKE 1627
Query: 1170 VIIKENFALECSPAFQVSDDEHEKMNKMK-FKVNRRTQKSGIGDRPLQDLSNTSFVSNNT 1228
+ A+ ++ EKM +++ K TQK + + +++ T + N
Sbjct: 1628 YQFLKMTAV---------NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678
Query: 1229 AESENKSEDLSSERT 1243
E + +++ R+
Sbjct: 1679 EEMRSVTKERDDLRS 1693
Score = 61.6 bits (148), Expect = 5e-09
Identities = 207/1047 (19%), Positives = 413/1047 (39%), Gaps = 171/1047 (16%)
Query: 321 EMQRNKQDLPGLSSESAR-----EPNAECMNQI-EDNDDFQLQKTVYDADMDLTASEVSK 374
+ + K +L + +E+ R N E M + ++ DD + + + D + +
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711
Query: 375 IVTVSTGIKKKSNKKT-----NEHGMKTFRKVKDSSSEKKRERSKRQFK--------NSS 421
T++ ++K+ K EH +T K++ SEK E S Q +
Sbjct: 1712 --TITRDLEKQEELKIVHMHLKEH-QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 422 DVDIGEKIE----NRTERSDVLDGKRG--AEDPGFIFN------------NEQLAQMNEQ 463
D+ I E++ + E+ + +D RG +E + N E++ ++
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
Query: 464 LAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQ 523
Q+ LKK +T + + E + K++ +T + E +L+ + K H+ + K
Sbjct: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQ-KLHENLEEMKSV 1887
Query: 524 NSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCD 583
N + KLE+D L + ++ T +L++ E TA + +K++ D
Sbjct: 1888 MKERDNLRRVEETL----KLERDQLKESLQE--TKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 584 YGTHNILDLKKYVTDIQPS-----EQNESNINKLRKK----------VNRKTEIISGMNH 628
I + ++DIQ ++ + I +L+KK VN + I+ M
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001
Query: 629 MYEDNDKD--VVHGLKKGNFFF--KTQEDKEPISENIEVSKELQIPALSTRDNENQCDYR 684
+ + + + ++ NF K E E I + EL+ S + +Q
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIAT 2061
Query: 685 TQNVLGLQKQITNMYP----VQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVK 740
+ ++ +Q + P + + + + LR+K +R E++ + +D+
Sbjct: 2062 LREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD--------- 2112
Query: 741 SHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQN 800
H L + + LE EF+ LS + NL +Q KH + A Q
Sbjct: 2113 -HYECLNRLSLD-----LEKEIEFQKE-LSMRVKANLSLPYLQT----KHIEKLFTANQR 2161
Query: 801 DS----KIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETIS--E 854
S +I KK + ++ +I E ++ ++ E D F K KE + +
Sbjct: 2162 CSMEFHRIMKKLKY-------VLSYVTKIKEEQHESINKFEMD-FIDEVEKQKELLIKIQ 2213
Query: 855 NLQVTNEFQTVDLL-IKDNGNLCDYDTQNIL------ELKKYVTDRKSAEQNESKINK-L 906
+LQ + + +L +K N N+ D + IL E T+ + N ++ + L
Sbjct: 2214 HLQQDCDVPSRELRDLKLNQNM-DLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFL 2272
Query: 907 RNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVN 966
+N + +I N I ++ND+ V + + +N+S + E I+K + +
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDL 2332
Query: 967 SNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHI 1026
+ KE +++ +Y+ + K + A+ T NK + ++Q + +L++
Sbjct: 2333 KSLKEKNEKLFKNYQTL---KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENS 2389
Query: 1027 TSEA-DSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKR--- 1082
EA +S ++ K QK+ T D+ I + + +V + NK K+K+
Sbjct: 2390 LHEAKESAMHKESKIIKMQKELEVT---NDI-----IAKLQAKVHESNKCLEKTKETIQV 2441
Query: 1083 ---KTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMV---KNKPDFYTKAF 1136
K ++ P E+ + ++ K + +N E EK + K ++ +
Sbjct: 2442 LQDKVALGAKPYKEEI-----EDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI 2496
Query: 1137 RSLSE--IHSPNIQDSSFDSVREGLVPLS---VSSGKNVIIKENFALECSPAFQVSDDEH 1191
R L E S QD+S S P + G + I++ AL + EH
Sbjct: 2497 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL-------ILKSEH 2549
Query: 1192 EKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNN-----------------TAESENK 1234
++ K K+ ++ ++ + + + LSN +SN T E+ K
Sbjct: 2550 IRLEKEISKLKQQNEQ--LIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607
Query: 1235 SEDLSSERTSRRRRCTPFYFKEPSLRD 1261
S ++ S++++ TP KE +L+D
Sbjct: 2608 SPKVTG-TASKKKQITPSQCKERNLQD 2633
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 67.4 bits (163), Expect = 8e-11
Identities = 227/1304 (17%), Positives = 505/1304 (38%), Gaps = 209/1304 (16%)
Query: 21 KDKRISKTTKLNVSLASKIKTKILNNSSIFKI--SLKHNNRALAQALSREKENSRRITTE 78
+ ++ + K N+ L +K+ + K L N L A + + S + E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 79 KMLLQKEVEKLNFENTFLRLKLNNL-NKKLIDIEALMNNNLITAIEMSSLS----EFHQS 133
+ + E L ++N L + +L+ +E + N +L +E + E + S
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE-MENQSLTKTVEELRTTVDSVEGNAS 491
Query: 134 SFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGS 193
L + +R+SK+ +++ ++ ++K+ +Q N+ + +
Sbjct: 492 KILKMEKENQRLSKKVEILE-----------NEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 194 TTQPLSTQDNSEVLFLKENN----QNVYGLDDSEHISS---IVDVPPRESHSHSDQSSKT 246
T + L ++ L++ N Q V L IS+ + D+ H +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 247 SLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELN 306
S +S++ +R K + E+ +R E N L +L K+ I++ ++
Sbjct: 601 SKLSKIE----FEKRQIKKELEHYKEKGERAEELE-NELHHLEKENELLQKK-ITNLKIT 654
Query: 307 CNN--EINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDAD 364
C + +E E ++ K+ L + + + + E N D ++ +L++ V
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES-- 712
Query: 365 MDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVD 424
L + + + +S K+ + G++ + +S KK ER + ++
Sbjct: 713 --LKCASMKMAQLQLENKELESEKEQLKKGLELLK-----ASFKKTERLEVSYQ------ 759
Query: 425 IGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDR 484
G IEN+ + + + +N+++ Q+ +L + E++ TLQ E+
Sbjct: 760 -GLDIENQRLQKTLEN------------SNKKIQQLESELQDL-EMENQTLQKNLEELKI 805
Query: 485 ENVLCNKKEKRITNEQEETYSLSQSSGKFHQESK----------------------FDKG 522
+ + EK + ++ET L + + +E+K +K
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 523 QNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLC 582
+L+ + +LEK+N ++ + I + + + + L T+ N
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 583 DYGTHNI----LDLKKYVTDIQPSEQNESNI------NKLRKKVNRKTEIISGMNHMYED 632
+ TH + L+ ++ + D Q ++ + + + L+K + K E I+ + E+
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985
Query: 633 NDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQ--------IPALSTRDN--ENQCD 682
+ N+ + +++ + + +N E K+ Q P +S DN E +
Sbjct: 986 ST----------NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 683 YRTQNVLGLQKQI----TNMYPVQQNESKVNKKLRQ-------------KVNRKTEIISE 725
T+ +L ++ ++ N +Q + + +L+Q + R+T + E
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095
Query: 726 VNHLDNDKSIEY-----TVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS 780
N ++ + T+ S S L ++ +++ +E E+ +D +LYDS
Sbjct: 1096 QNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDS 1155
Query: 781 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKS------EIIPETNQIYENDNKGVH 834
I++ ++ H+ Q A + +S I K L K+ ++ NQ+ + + +
Sbjct: 1156 LIKDHEKLELLHERQ-ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ-LE 1213
Query: 835 DLEK-------------DNFFSLTPKDKETISENLQVTNEF----QTVDLLIKDNGNLCD 877
DLEK N ++ + K+ EN ++ + + + ++L D+ NL
Sbjct: 1214 DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 878 YDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESY 937
+ LE + + ++ +++ K+N + E++S++ E+ ++ H+ +
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR--HLLDQI 1331
Query: 938 TKDLDFKVNKSKQKLECQDIIN---KHYM----EVNSNEKESCDQILDSYK--------- 981
+ +Q +E +D+ + + Y+ E+ +++ ++I+D YK
Sbjct: 1332 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRR 1391
Query: 982 -----VVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGN 1036
+K RK S K N + L ++SS+ + L +S S+
Sbjct: 1392 RGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE 1451
Query: 1037 PVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRK---------TSID 1087
+ T+K ST + + + G + +V S K+RK T+I+
Sbjct: 1452 DGQTLGTKKSSTMNDLVQSMVLAGQ-WTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1510
Query: 1088 PSPESHEVMERILDSVQGKST-----VSEQADKENNLENEKMVKNKPDFYTKAFRSLSEI 1142
S + R V K T +S Q +++ ++ ++P S S
Sbjct: 1511 FSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNS 1570
Query: 1143 HSPNIQDSSFDSVREGLV-----PLSVSSGKNVIIKENFALECS 1181
++ ++S V+ G V P S SSG+ ++ ++ A S
Sbjct: 1571 NN----NASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSS 1610
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 67.0 bits (162), Expect = 1e-10
Identities = 210/1093 (19%), Positives = 422/1093 (38%), Gaps = 169/1093 (15%)
Query: 202 DNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRR 261
D +++L + N GLDD D P +S S + L+ N +
Sbjct: 209 DVAKILIAAGADVNTQGLDD--------DTPLHDSASSGHRDIVKLLLRHGGNPFQANKH 260
Query: 262 WEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTE 321
E+P TE + E LS D T ++ +P + + I+ T E ++
Sbjct: 261 GERPVDVAETEELELLLKREVP-LSDDDESYTDSEEAQSVNPS-SVDENIDSET-EKDSL 317
Query: 322 MQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDAD-MDLTASEVSKIVTVST 380
+ +KQ LP + P+A + +D+DD ++ K + D + + ++ T
Sbjct: 318 ICESKQILPSKTPL----PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 373
Query: 381 GIKKKSNKKTNEHGMKTFR----KVKDSSSEKKRERSKRQFKNSSDVDIGEKIEN---RT 433
+ K K K+ + +V SS+E E + + K S+ + + N +T
Sbjct: 374 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQT 433
Query: 434 ERSDVLDGKRGAEDPGFI---FNNEQLAQMNEQLAQVNELKK------MTLQTGFEQGDR 484
++ V+ G+ + G + N+ + N++L Q E K+ +T+ TG + ++
Sbjct: 434 KKEYVVSGEH--KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEK 491
Query: 485 ENVLCNKKEKRITNEQEETYSLSQSSGKF--------HQESKFDKGQNSLTCNKSKASRQ 536
N ++ + + S+GK ++S K +++ TC +S
Sbjct: 492 TREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM 551
Query: 537 TFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYV 596
+ L+ D + + + + E+ V + H + + +L ++G + +K
Sbjct: 552 S-----LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL-EFGEKSNAKIKD-- 603
Query: 597 TDIQPS-EQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKE 655
D P+ E ++ + K+ K+ + ++ K + G K+ +KT++ +
Sbjct: 604 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK---YKTKDSAK 660
Query: 656 PISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQK 715
+ ++E +E ++N + D L ++ + + + +SK+ K ++
Sbjct: 661 ELQRSVEFDREFW------KENFFKSDETEDLFLNMEHESLTL----EKKSKLEKNIKDD 710
Query: 716 VNRKTEIISEVNHLDND-----KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALS 770
+ K + +S+ + + K E + + + ++++E IP + + SEF + +S
Sbjct: 711 KSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD--SEFTSLGMS 768
Query: 771 TKDSG---NLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYE 827
+ +L + EI KH + + + S+I +K +I + +E
Sbjct: 769 AIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK---------DIEKMERKTFE 819
Query: 828 NDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYD---TQNIL 884
+ K H+ + + KDK +SE ++ + D L + C + ++N
Sbjct: 820 KEKKIKHEHKSE-------KDKLDLSE---CVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 869
Query: 885 ELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFK 944
+KK KS E+ + K +K E +K+ H+ ES K L K
Sbjct: 870 AIKKTDDREKSREKMDRKHDK-------------------EKPEKERHLAESKEKHLMEK 910
Query: 945 VNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESS--CKAKNILTKAK 1002
NK N Y + + + D+ LD K K R KES +K+I + K
Sbjct: 911 KNKQSD--------NSEYSKSEKGKNKEKDRELD--KKEKSRDKESINITNSKHIQEEKK 960
Query: 1003 NKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEI 1062
+ + + +SL+ K E KT KD+ +E
Sbjct: 961 SSIVDGNKAQHEKPLSLKEKTKD-------------EPLKTPDGKEKDKKDKDIDRYKER 1007
Query: 1063 KE--GECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLE 1120
+ + Q+ + K+ S++ K K P+ + E+ L + T E+ +LE
Sbjct: 1008 DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLE 1067
Query: 1121 NEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVRE-GLVPLSVSSGKNV----IIKEN 1175
E+ K H I+ + +R + L + + +N
Sbjct: 1068 IEQWHKK---------------HKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1112
Query: 1176 FALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNN----TAES 1231
L S + +V+D + K + K V+ R+Q + + + L +SFVS+N + S
Sbjct: 1113 KELTRSKSSEVTD-AYTKEKQPKDAVSNRSQS--VDTKNVMTLGKSSFVSDNSLNRSPRS 1169
Query: 1232 ENKSEDLSSERTS 1244
EN+ LSS S
Sbjct: 1170 ENEKPGLSSRSVS 1182
Score = 55.1 bits (131), Expect = 4e-07
Identities = 235/1268 (18%), Positives = 471/1268 (37%), Gaps = 185/1268 (14%)
Query: 30 KLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKL 89
K+ ++ + + T+ L++ + S +R + + L R N + ++ V+
Sbjct: 212 KILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHG---ERPVDVA 268
Query: 90 NFENTFLRLK----LNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRI 145
E L LK L++ ++ D E + N ++++ + SE + S L+ SK+
Sbjct: 269 ETEELELLLKREVPLSDDDESYTDSEEAQSVNP-SSVDENIDSETEKDS-LICESKQILP 326
Query: 146 SKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI--KSKTLPDIPSSGST--------- 194
SK LP A DD+DE+ KM D +I K + + P + T
Sbjct: 327 SKT----PLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKA 382
Query: 195 ----TQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMS 250
+ Q S VL+ + + L + + IS+ V P S+S + +
Sbjct: 383 FYPKSFKSKKQKPSRVLYSSTESSDEEALQNKK-ISTSCSVIPETSNSDMQTKKEYVVSG 441
Query: 251 EMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNE 310
E + + R+ + + + + K+ + N + T LD + E N
Sbjct: 442 EHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKS 501
Query: 311 INGHTNET----NTEMQRNKQDLPGLSSESA----REPNAECMNQIEDNDDFQLQKTVYD 362
+ + + + ++ + GLS + + +E C++ Q YD
Sbjct: 502 FSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 561
Query: 363 ADMDLTASEVSKIVTVSTGIKKKSNKKTN-EHGMKTFRKVKDSSSEKKRERSKRQFKNSS 421
E S + + K K K + E G K+ K+KD E S K
Sbjct: 562 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK-KM 620
Query: 422 DVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQ 481
D + +++ + + K E G + E V ++ + F+
Sbjct: 621 DKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKS 680
Query: 482 GDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIH 541
+ E++ N + + +T E++ + K +E K +N + K +++
Sbjct: 681 DETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN-FKEERDKIKKESEKSF 739
Query: 542 KLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNI---LDLKKYVTD 598
+ EK L +++ + D +EF + +S + G H + +D++K
Sbjct: 740 REEKIKDLKEERENIP----TDKDSEFTSLGMSAIEE----SIGLHLVEKEIDIEKQEKH 791
Query: 599 IQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPIS 658
I+ S++ K K+ K + I M + +K + H K+++DK +S
Sbjct: 792 IKESKE------KPEKRSQIKEKDIEKMERKTFEKEKKIKHE-------HKSEKDKLDLS 838
Query: 659 ENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR 718
E ++ KE + + T+ ++ N +++ + + +K R+K++R
Sbjct: 839 ECVDKIKE----------KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR--EKSREKMDR 886
Query: 719 K--TEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGN 776
K E + HL K K + Q D + + ++ + L K+
Sbjct: 887 KHDKEKPEKERHLAESKEKHLMEKKNK----QSDNSEYSKSEKGKNKEKDRELDKKEKSR 942
Query: 777 LYDSEIQNVLGVKH-GHDMQPACQNDSKIGKKPRLNVCQKSEIIP-ETNQIYENDNKGVH 834
D E N+ KH + + + + +K + L++ +K++ P +T E D K
Sbjct: 943 --DKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK--- 997
Query: 835 DLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRK 894
D + D + K+++ + +Q+ ++L+LK K
Sbjct: 998 DKDIDRY-----KERDKHKDKIQI----------------------NSLLKLKSEADKPK 1030
Query: 895 SAEQNESKINKLRNK--VNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKL 952
SK + + K VN D +Q S+ + L K L
Sbjct: 1031 PKSSPASKDTRPKEKRLVN------------------DDLMQTSFERMLSLK------DL 1066
Query: 953 ECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTES 1012
E + KH ++ EKE L + ++ + K+ K K+ T++KNK ++ S
Sbjct: 1067 EIEQWHKKHKEKIKQKEKER----LRNRNCLELKIKDKE-KTKHTPTESKNKELTRSKSS 1121
Query: 1013 SQT-SISLESDLKHITSEADS--DPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQV 1069
T + + E K S D N + L K+ S +LN+ E+ V
Sbjct: 1122 EVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSV 1181
Query: 1070 KKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQ---------ADKENNLE 1120
++ +S+ T P P + +L+S + + + S+ A E L+
Sbjct: 1182 SMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELD 1241
Query: 1121 N--EKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFAL 1178
+ + + KP + + S S + S +++D V L +S G+ I ++
Sbjct: 1242 SLADLPERIKPPYANRL--STSHLRSSSVED----------VKLIISEGRPTIEVRRCSM 1289
Query: 1179 -----ECSPAFQVSDDEHEKMNKMKFKVNRRTQK-----SGIGDRPLQDLSN--TSFVSN 1226
E + FQ +E + + + + S + +R L ++SN +SF ++
Sbjct: 1290 PSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATS 1349
Query: 1227 NTAESENK 1234
T S +K
Sbjct: 1350 PTGASNSK 1357
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 67.0 bits (162), Expect = 1e-10
Identities = 210/1093 (19%), Positives = 422/1093 (38%), Gaps = 169/1093 (15%)
Query: 202 DNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRR 261
D +++L + N GLDD D P +S S + L+ N +
Sbjct: 232 DVAKILIAAGADVNTQGLDD--------DTPLHDSASSGHRDIVKLLLRHGGNPFQANKH 283
Query: 262 WEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTE 321
E+P TE + E LS D T ++ +P + + I+ T E ++
Sbjct: 284 GERPVDVAETEELELLLKREVP-LSDDDESYTDSEEAQSVNPS-SVDENIDSET-EKDSL 340
Query: 322 MQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDAD-MDLTASEVSKIVTVST 380
+ +KQ LP + P+A + +D+DD ++ K + D + + ++ T
Sbjct: 341 ICESKQILPSKTPL----PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 396
Query: 381 GIKKKSNKKTNEHGMKTFR----KVKDSSSEKKRERSKRQFKNSSDVDIGEKIEN---RT 433
+ K K K+ + +V SS+E E + + K S+ + + N +T
Sbjct: 397 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQT 456
Query: 434 ERSDVLDGKRGAEDPGFI---FNNEQLAQMNEQLAQVNELKK------MTLQTGFEQGDR 484
++ V+ G+ + G + N+ + N++L Q E K+ +T+ TG + ++
Sbjct: 457 KKEYVVSGEH--KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEK 514
Query: 485 ENVLCNKKEKRITNEQEETYSLSQSSGKF--------HQESKFDKGQNSLTCNKSKASRQ 536
N ++ + + S+GK ++S K +++ TC +S
Sbjct: 515 TREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM 574
Query: 537 TFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYV 596
+ L+ D + + + + E+ V + H + + +L ++G + +K
Sbjct: 575 S-----LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL-EFGEKSNAKIKD-- 626
Query: 597 TDIQPS-EQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKE 655
D P+ E ++ + K+ K+ + ++ K + G K+ +KT++ +
Sbjct: 627 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK---YKTKDSAK 683
Query: 656 PISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQK 715
+ ++E +E ++N + D L ++ + + + +SK+ K ++
Sbjct: 684 ELQRSVEFDREFW------KENFFKSDETEDLFLNMEHESLTL----EKKSKLEKNIKDD 733
Query: 716 VNRKTEIISEVNHLDND-----KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALS 770
+ K + +S+ + + K E + + + ++++E IP + + SEF + +S
Sbjct: 734 KSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD--SEFTSLGMS 791
Query: 771 TKDSG---NLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYE 827
+ +L + EI KH + + + S+I +K +I + +E
Sbjct: 792 AIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK---------DIEKMERKTFE 842
Query: 828 NDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYD---TQNIL 884
+ K H+ + + KDK +SE ++ + D L + C + ++N
Sbjct: 843 KEKKIKHEHKSE-------KDKLDLSE---CVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
Query: 885 ELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFK 944
+KK KS E+ + K +K E +K+ H+ ES K L K
Sbjct: 893 AIKKTDDREKSREKMDRKHDK-------------------EKPEKERHLAESKEKHLMEK 933
Query: 945 VNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESS--CKAKNILTKAK 1002
NK N Y + + + D+ LD K K R KES +K+I + K
Sbjct: 934 KNKQSD--------NSEYSKSEKGKNKEKDRELD--KKEKSRDKESINITNSKHIQEEKK 983
Query: 1003 NKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEI 1062
+ + + +SL+ K E KT KD+ +E
Sbjct: 984 SSIVDGNKAQHEKPLSLKEKTKD-------------EPLKTPDGKEKDKKDKDIDRYKER 1030
Query: 1063 KE--GECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLE 1120
+ + Q+ + K+ S++ K K P+ + E+ L + T E+ +LE
Sbjct: 1031 DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLE 1090
Query: 1121 NEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVRE-GLVPLSVSSGKNV----IIKEN 1175
E+ K H I+ + +R + L + + +N
Sbjct: 1091 IEQWHKK---------------HKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1135
Query: 1176 FALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNN----TAES 1231
L S + +V+D + K + K V+ R+Q + + + L +SFVS+N + S
Sbjct: 1136 KELTRSKSSEVTD-AYTKEKQPKDAVSNRSQS--VDTKNVMTLGKSSFVSDNSLNRSPRS 1192
Query: 1232 ENKSEDLSSERTS 1244
EN+ LSS S
Sbjct: 1193 ENEKPGLSSRSVS 1205
Score = 55.1 bits (131), Expect = 4e-07
Identities = 235/1268 (18%), Positives = 471/1268 (37%), Gaps = 185/1268 (14%)
Query: 30 KLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKL 89
K+ ++ + + T+ L++ + S +R + + L R N + ++ V+
Sbjct: 235 KILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHG---ERPVDVA 291
Query: 90 NFENTFLRLK----LNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRI 145
E L LK L++ ++ D E + N ++++ + SE + S L+ SK+
Sbjct: 292 ETEELELLLKREVPLSDDDESYTDSEEAQSVNP-SSVDENIDSETEKDS-LICESKQILP 349
Query: 146 SKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI--KSKTLPDIPSSGST--------- 194
SK LP A DD+DE+ KM D +I K + + P + T
Sbjct: 350 SKT----PLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKA 405
Query: 195 ----TQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMS 250
+ Q S VL+ + + L + + IS+ V P S+S + +
Sbjct: 406 FYPKSFKSKKQKPSRVLYSSTESSDEEALQNKK-ISTSCSVIPETSNSDMQTKKEYVVSG 464
Query: 251 EMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNE 310
E + + R+ + + + + K+ + N + T LD + E N
Sbjct: 465 EHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKS 524
Query: 311 INGHTNET----NTEMQRNKQDLPGLSSESA----REPNAECMNQIEDNDDFQLQKTVYD 362
+ + + + ++ + GLS + + +E C++ Q YD
Sbjct: 525 FSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 584
Query: 363 ADMDLTASEVSKIVTVSTGIKKKSNKKTN-EHGMKTFRKVKDSSSEKKRERSKRQFKNSS 421
E S + + K K K + E G K+ K+KD E S K
Sbjct: 585 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK-KM 643
Query: 422 DVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQ 481
D + +++ + + K E G + E V ++ + F+
Sbjct: 644 DKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKS 703
Query: 482 GDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIH 541
+ E++ N + + +T E++ + K +E K +N + K +++
Sbjct: 704 DETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN-FKEERDKIKKESEKSF 762
Query: 542 KLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNI---LDLKKYVTD 598
+ EK L +++ + D +EF + +S + G H + +D++K
Sbjct: 763 REEKIKDLKEERENIP----TDKDSEFTSLGMSAIEE----SIGLHLVEKEIDIEKQEKH 814
Query: 599 IQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPIS 658
I+ S++ K K+ K + I M + +K + H K+++DK +S
Sbjct: 815 IKESKE------KPEKRSQIKEKDIEKMERKTFEKEKKIKHE-------HKSEKDKLDLS 861
Query: 659 ENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR 718
E ++ KE + + T+ ++ N +++ + + +K R+K++R
Sbjct: 862 ECVDKIKE----------KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR--EKSREKMDR 909
Query: 719 K--TEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGN 776
K E + HL K K + Q D + + ++ + L K+
Sbjct: 910 KHDKEKPEKERHLAESKEKHLMEKKNK----QSDNSEYSKSEKGKNKEKDRELDKKEKSR 965
Query: 777 LYDSEIQNVLGVKH-GHDMQPACQNDSKIGKKPRLNVCQKSEIIP-ETNQIYENDNKGVH 834
D E N+ KH + + + + +K + L++ +K++ P +T E D K
Sbjct: 966 --DKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK--- 1020
Query: 835 DLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRK 894
D + D + K+++ + +Q+ ++L+LK K
Sbjct: 1021 DKDIDRY-----KERDKHKDKIQI----------------------NSLLKLKSEADKPK 1053
Query: 895 SAEQNESKINKLRNK--VNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKL 952
SK + + K VN D +Q S+ + L K L
Sbjct: 1054 PKSSPASKDTRPKEKRLVN------------------DDLMQTSFERMLSLK------DL 1089
Query: 953 ECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTES 1012
E + KH ++ EKE L + ++ + K+ K K+ T++KNK ++ S
Sbjct: 1090 EIEQWHKKHKEKIKQKEKER----LRNRNCLELKIKDKE-KTKHTPTESKNKELTRSKSS 1144
Query: 1013 SQT-SISLESDLKHITSEADS--DPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQV 1069
T + + E K S D N + L K+ S +LN+ E+ V
Sbjct: 1145 EVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSV 1204
Query: 1070 KKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQ---------ADKENNLE 1120
++ +S+ T P P + +L+S + + + S+ A E L+
Sbjct: 1205 SMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELD 1264
Query: 1121 N--EKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFAL 1178
+ + + KP + + S S + S +++D V L +S G+ I ++
Sbjct: 1265 SLADLPERIKPPYANRL--STSHLRSSSVED----------VKLIISEGRPTIEVRRCSM 1312
Query: 1179 -----ECSPAFQVSDDEHEKMNKMKFKVNRRTQK-----SGIGDRPLQDLSN--TSFVSN 1226
E + FQ +E + + + + S + +R L ++SN +SF ++
Sbjct: 1313 PSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATS 1372
Query: 1227 NTAESENK 1234
T S +K
Sbjct: 1373 PTGASNSK 1380
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 62.4 bits (150), Expect = 3e-09
Identities = 160/869 (18%), Positives = 329/869 (37%), Gaps = 112/869 (12%)
Query: 318 TNTEMQRNKQDLPGLSSESAREPNAECMNQIED---NDDF----QLQKTVYDADMDLTA- 369
T++ N+ DL SS ++ +P ++ ++ ED N D QL + + + L++
Sbjct: 96 TSSRESLNRLDLD--SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSY 153
Query: 370 -SEVSKIVTVSTGI---KKKSNKKTNEHGMKTFRKVKDSSSEKKRER-SKRQFKNSSDVD 424
+ S++VT + KKK ++ K+ R++ + E + ++ +K+ + D
Sbjct: 154 RGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDAS 213
Query: 425 IGEK-----------------IENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQV 467
+ EK + N DVL E +F E+ + + +
Sbjct: 214 LEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVE 273
Query: 468 NELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLT 527
+ TL+T ++ R+ L + ++ I + +E+ L+ S K + + D+ L
Sbjct: 274 DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT--SEKEALQEQLDERLQELE 331
Query: 528 CNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTH 587
K +H EK L+ +D + E L+ +D G +
Sbjct: 332 KIKD--------LHMAEKTKLITQLRDAKNLIEQLE------------QDKGMV------ 365
Query: 588 NILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFF 647
I + K+ + + E E I +LR ++ + T + E +++ L+K
Sbjct: 366 -IAETKRQMHETL--EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA--- 419
Query: 648 FKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESK 707
T + E ++ + QI + E + + + Q+ + M + +
Sbjct: 420 LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA 479
Query: 708 VNKKLRQK--VNRKTEIISEVNHLDNDKSIEYTV---KSHSLFLT-QKDKEIIPGNLEDP 761
+KL +K ++ E+ ++ + + + V KS S +L ++KE +
Sbjct: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 762 SEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPE 821
E + A+ T+ L D L + + +S + K + N Q ++
Sbjct: 540 LELQKKAILTESENKLRD------LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH 593
Query: 822 TNQIYENDNKGVH---DLEKDNFFSLTPKDKETISENLQVTNE-FQTVDLLIKDNGNLCD 877
NK + + K SL + +E LQV + +QT +++ C+
Sbjct: 594 LEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK---CE 650
Query: 878 YDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESY 937
+ + +L+ K+ + E NE + KL K + SE++++ K H E
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL----KARHKLEEE 706
Query: 938 TKDLDFKVNKSKQKLECQ-------------DIINKHYMEVNSNEKESCDQILDSYKVVK 984
L + +K KQ+LE + II +H + + EK DQI ++K
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 985 KRK---KESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELC 1041
+R KE +N+ K E Q S L+ + ++ + +L
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEG----ELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 1042 KTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSI--DPSPESHEVMERI 1099
+ Q Q L + + +++ E E Q K V K + + ++ E+ +++
Sbjct: 823 QLQ-QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV 881
Query: 1100 LDSVQGKSTVSEQADKENNLENEKMVKNK 1128
Q + E +KE + +V+ +
Sbjct: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Score = 58.9 bits (141), Expect = 3e-08
Identities = 209/1205 (17%), Positives = 471/1205 (39%), Gaps = 193/1205 (16%)
Query: 16 IKRHLKDKRISKTTKLNVS--------LASKIKTKILNNSSIFKISLKHNNRALAQALSR 67
+ + +++I+K KL+ L K++T+ K++L+ + + +S+
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK-ISQ 527
Query: 68 EKENSRRITTEKMLLQKEVEKLNFENTF--LRLKLNNLNKKLIDIEALMNNNLIT----- 120
EKE + E++ LQK+ EN L+ + +++++E+ + +L
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 121 ---AIEMSSLSEFHQSSFLLSASKKKRISKQCK------------LMRLPFARVPLTSND 165
A+ + + H + K K + K +++ + +
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 166 DEDEDKEKMQCDNNI---------KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNV 216
+++KE + D I KTL + + + LS++ SEVL + +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE-LSEVLKARHKLEEE 706
Query: 217 YGL--DDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVT--- 271
+ D ++ + ++ E +H Q + + + Q R EK +
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ----RTEKALKDQINQLE 762
Query: 272 ----ERKKRGSSWESN--NLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRN 325
ER K +++ NL AD + +Q +S +L+ T+E +
Sbjct: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQ--ASAKLDVFQSYQSATHEQTKAYEEQ 820
Query: 326 KQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKK 385
L + + E + + + + QK ++D +V ++ ++K+
Sbjct: 821 LAQL----QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ---LEKQ 873
Query: 386 SNKKTNEHGMKTFRKVKDSSSE---KKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGK 442
+++ E +K+ +V +S E K++E++K+ ++ I + E + + ++L K
Sbjct: 874 NSEM--EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM-ILQMREGQKKEIEILTQK 930
Query: 443 RGA-EDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQE 501
A ED I N E + Q ++ ++K+ + ++ ++ +L +E ++ E E
Sbjct: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE--MQETLKKKLL--DQEAKLKKELE 986
Query: 502 ET-YSLSQSSGKFHQESKFDKGQNS---------LTCNKSKASRQTFVIHKLEKDNLLPN 551
T LSQ +F+ + NS L N+ + +H+ E ++++
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI 1046
Query: 552 QKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNIL------DLKKYVTDI-QPSEQ 604
+ K+ + + E H L K+ + + +L ++ K +T + + +
Sbjct: 1047 WEKKLN--QQAEELQEIHEIQLQEKEQ-EVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
Query: 605 NESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQED-KEPISENIEV 663
++ +N+L++++ +K+ + +N + +D K H K + D + + EN +
Sbjct: 1104 QDTTLNELQEQLKQKS---AHVNSLAQDETKLKAH-------LEKLEVDLNKSLKENTFL 1153
Query: 664 SKEL-QIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEI 722
++L ++ L+ D ++T+ E + K +K N+ E
Sbjct: 1154 QEQLVELKMLAEEDKRKV------------SELTSKLKTTDEEFQSLKSSHEKSNKSLE- 1200
Query: 723 ISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEI 782
DKS+E+ S L + +I E E +T L N+ S+
Sbjct: 1201 ---------DKSLEFKKLSEELAI---QLDICCKKTEALLEAKTNELI-----NISSSKT 1243
Query: 783 QNVLG-VKHGHDMQPACQN-DSKIGKKPRLNVCQKSEIIPETNQIYENDN-------KGV 833
+L + H CQ+ +K+ + + C SE+ + Q+ E N +
Sbjct: 1244 NAILSRISH-------CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
Query: 834 HDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDR 893
H LE+ K+ + S + + + L K+ GN +
Sbjct: 1297 HQLEE--------KENQIKSMKADIESLVTEKEALQKEGGN-----------------QQ 1331
Query: 894 KSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLE 953
++A + ES I +L+ +++ ++ M + ++ + DL+ ++ S E
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE 1391
Query: 954 CQDIINKHYMEVNSNEKESCDQILD-SYKVVKKRKKESSCKAK-----NILTKAKNKLAS 1007
+ I+ + + + E DQ+ D S+KV K++ S + N ++ K K S
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS 1451
Query: 1008 QLTESSQTSISLESDLKHITSEA-DSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGE 1066
+ T+ T L+ L+ + EA + D E K+ NK+ E+++ +
Sbjct: 1452 RFTQHQNTVKELQIQLELKSKEAYEKD-----EQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 1067 CQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVK 1126
+++K K +T+ E H + I ++ + V + +++ ++E++++V+
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTI--EIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 1127 NKPDF 1131
F
Sbjct: 1565 KLQHF 1569
Score = 52.8 bits (125), Expect = 2e-06
Identities = 189/1078 (17%), Positives = 392/1078 (36%), Gaps = 198/1078 (18%)
Query: 158 RVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVY 217
R P+ + KE + ++ +S D+ SS ++ P S D+ +++
Sbjct: 77 RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEA--------EDLV 128
Query: 218 GLDDSEHISSIVDVPPRESHSHSDQSSKTS--------LMSEMRNAQSIGRRWEKPSPSN 269
G DS + ++ R S S K S L E + Q I + + S
Sbjct: 129 GNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRR 188
Query: 270 VTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDL 329
+ E ++ L D L ++ +S E E + + + T++ KQ L
Sbjct: 189 IAELREE--------LQMDQQAKKHLQEEFDASLE-----EKDQYISVLQTQVSLLKQRL 235
Query: 330 PG-------LSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGI 382
L EP AE + E+N + + V D T + + V +
Sbjct: 236 RNGPMNVDVLKPLPQLEPQAEVFTK-EENPESDGEPVVEDGTSVKTLETLQQRVKRQENL 294
Query: 383 KKKSNKKTNEHGMK-TFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDG 441
K+ + H + T + + +++ + ++ + D+ + EK + T+ D +
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL 354
Query: 442 KRGAE-DPGFIFN------NEQLAQMNEQLAQV-NELKKMTLQTGFEQGDRENVLCNKKE 493
E D G + +E L E++AQ+ + +K+MT Q G+ K E
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ-----GEELREQKEKSE 409
Query: 494 KRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQK 553
+ E E+ S +Q + + ++ K + + T K+ +++
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT-------------------SEE 450
Query: 554 DKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLR 613
+++++ + L + ++D+ K ++ Q ++ + + +L
Sbjct: 451 ERISLQQELSRVKQ--------------------EVVDVMKKSSEEQIAKLQKLHEKELA 490
Query: 614 KKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALS 673
+K T+ + +++ K + K + + K ++KE ELQ A+
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALE--KSQSEYLKISQEKEQQESLALEELELQKKAIL 548
Query: 674 T------RDNENQCDYRTQNVLGLQKQITNMYPVQQNESKV------------NKKLRQK 715
T RD + + + +L L+ + +N+SK NK++
Sbjct: 549 TESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
Query: 716 VNR------------------KTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEII-PG 756
V + K +++ + + +K E + L KDKEII
Sbjct: 609 VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL--KDKEIIFQA 666
Query: 757 NLEDPSEFETPALSTKDSG-NLYDSEIQNVLGVKHGHDMQPACQND----------SKIG 805
++E+ +E L K + SE+ VL +H + + + D +K+
Sbjct: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
Query: 806 KKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTV 865
++ + Q II E + K + D L +DK V N +
Sbjct: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
Query: 866 DLLIKDNGNLCDYDTQ-NILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIY 924
+ G L + ++ + + T ++ E + ++ +TE I Q+
Sbjct: 787 K---RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVA 843
Query: 925 EDN--------DKDAH-VQ-ESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCD 974
E + DAH +Q + + L+ + ++ +QK++ + + +E + E+E
Sbjct: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 975 QILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDP 1034
QIL + + + +E K ILT+ +S + D HI +E
Sbjct: 904 QILVEKENMILQMREGQKKEIEILTQ---------------KLSAKEDSIHILNEEYETK 948
Query: 1035 GNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKK--RKTSIDPSPES 1092
K Q++ + +K E +K KK+ +K KK T+++ S +
Sbjct: 949 ------FKNQEKKMEKVKQKAKEMQETLK------KKLLDQEAKLKKELENTALELSQKE 996
Query: 1093 HEVMERILDSVQGKST-VSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQD 1149
+ ++L+ Q S +S+ + + E++ SL+E+H + D
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQI------------ESLTEVHRRELND 1042
Score = 37.7 bits (86), Expect = 0.070
Identities = 208/1150 (18%), Positives = 430/1150 (37%), Gaps = 199/1150 (17%)
Query: 37 SKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEK--MLLQ------KEVEK 88
S+++ K+ + + +++ L+ N+ E+E +++I EK M+LQ KE+E
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNK--------EQEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 89 LNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQ 148
L + + ++ LN+ + E N + + + Q + + + KK++ Q
Sbjct: 927 LTQKLSAKEDSIHILNE---EYETKFKN------QEKKMEKVKQKAKEMQETLKKKLLDQ 977
Query: 149 CKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEV-- 206
++ L + E + KM S + D S T Q + +EV
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 207 --------LFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLM----SEMRN 254
++ K+ NQ +E + I ++ +E + + L+ E N
Sbjct: 1038 RELNDVISIWEKKLNQQ------AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 255 AQSIGRRWE---KPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEI 311
+ + E + + N + + + S N+L+ D T L K H+ E++ N +
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE---TKL-KAHLEKLEVDLNKSL 1147
Query: 312 NGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASE 371
+ NT +Q +L L+ E R+ + +++FQ K+ ++
Sbjct: 1148 -----KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE--------- 1193
Query: 372 VSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEK-----KRERSKRQFKNSSDVDIG 426
KSNK + ++ F+K+ + + + K+ + + K + ++I
Sbjct: 1194 -------------KSNKSLEDKSLE-FKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 427 EKIENRT-ERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRE 485
N R + + ++++ QL Q+ E ++ TL F+Q +
Sbjct: 1240 SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE-EQNTLNISFQQATHQ 1298
Query: 486 NVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEK 545
+KE +I + + + SL +E G N + AS + I +L+K
Sbjct: 1299 ---LEEKENQIKSMKADIESLVTEKEALQKE-----GGNQ----QQAASEKESCITQLKK 1346
Query: 546 DNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQN 605
+ + EN++ K I L K +TD+ QN
Sbjct: 1347 E-----------LSENINAVTLMKEELKEKKVE----------ISSLSKQLTDLNVQLQN 1385
Query: 606 ESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSK 665
++++ K IS + Y++ +++ ++ +F T KE IS +V
Sbjct: 1386 SISLSE-------KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS-KEKISALEQVDD 1437
Query: 666 ELQIPALSTRDNENQCDYRTQNVLGLQKQIT----NMYPVQQNESKVNKKLRQKVNR--- 718
+ + +++ V LQ Q+ Y + + + ++L Q+ R
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
Query: 719 -KTEIISEVNHLDNDKS-IEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGN 776
K E+ + + ++ +S +E +KS + + + + I +E S E K+
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV----LKNYNQ 1553
Query: 777 LYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDL 836
D E + ++ K H + + D+++ + + +I+ NQ+Y +
Sbjct: 1554 QKDIEHKELVQ-KLQHFQELGEEKDNRVKEA-------EEKILTLENQVYSMKAE----- 1600
Query: 837 EKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSA 896
L K KE NL V ++ + + L L + ELK+ + +A
Sbjct: 1601 -------LETKKKELEHVNLSVKSKEEELKAL---EDRLESESAAKLAELKRKAEQKIAA 1650
Query: 897 EQNE--SKINKLRNKVNWKTEI-ISEMNQIYEDNDKDAHVQESYTKDLDFKVNKS----- 948
+ + S++ + + TE +SE+N ++ +++ H+ E K ++ +++
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 949 ----------KQKLECQDIINKHY------MEVNSNEKESCDQILDSYK-VVKKRKKESS 991
+++ + Q + K Y ++ N EKE Q + K E
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR 1770
Query: 992 CKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVEL--CKTQKQSTT 1049
C+ + L K ++ A Q + S L+ +L+ + VE K Q+
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIG-HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQ 1829
Query: 1050 TLNK--KDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKS 1107
L D+ + KE CQ+ + K K+ + + E H V L S K
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQI-----LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
Query: 1108 TVSEQADKEN 1117
+Q D N
Sbjct: 1885 QALQQMDGRN 1894
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 61.2 bits (147), Expect = 6e-09
Identities = 187/1038 (18%), Positives = 393/1038 (37%), Gaps = 139/1038 (13%)
Query: 138 SASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQP 197
SA++ + K ++P D DKE+ D K K+ D G T P
Sbjct: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP 275
Query: 198 LS----------------TQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHS--- 238
S T++++ ++ L ++ Q + SE + D ++ S
Sbjct: 276 KSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQ----ESSEQKNKSTDKGEKKPDSNEK 331
Query: 239 ----------------HSDQSSKTSLMSEMRNA-QSIGRRWEKPSPSNVTERKK-RGSSW 280
HS +S T + + + A + + PS N + K G+
Sbjct: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKE 391
Query: 281 ESNNLSADTPCATVLDKQHISSPELNCNNE------INGHTNE----TNTEMQRNKQDLP 330
+ + + +D T + + + +L+ E + + E T+ + ++NKQ+
Sbjct: 392 DFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKT 451
Query: 331 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTG---IKKKSN 387
+ + E + + + + K D+D +LT + + + ++++ N
Sbjct: 452 KTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQIN 511
Query: 388 KKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEK---IENRTERSDVLDGKRG 444
++ E K + SS K + RS + SS + K I+ + VL+ K+
Sbjct: 512 REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLE-KKV 570
Query: 445 AEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETY 504
A ++ + + +++ Q E K TL+T E ++E + +K+ K + + E +
Sbjct: 571 ALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTS-EHCEKEKISSSKELKHVHAKSEPSK 629
Query: 505 SLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDV 564
+ S H + +K ++ L + + ++ ++++ + K +V E
Sbjct: 630 PARRLSESLHVVDE-NKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTE 688
Query: 565 TNEFHTANLSTKDNGNLCDYGTHNILD-LKKYVTDIQPSEQNESNINKLRKKVNRKTEII 623
+ + L + + D T ++ LKK V + + E ++ + V K +
Sbjct: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYK-- 746
Query: 624 SGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDY 683
+ M++ D+ +H +KG K +E+ + S+ ++S + + S NE
Sbjct: 747 --GDCMHKTGDETELHSSEKG---LKVEENIQKQSQQTKLSSDDKTERKSKHRNE----- 796
Query: 684 RTQNVLGLQKQITNMYPVQQNES--KVNKKLRQKVNRKTEIISEVNHLDNDKSIE---YT 738
R +VLG + + Y ++ +E+ K N K ++++ + + +D I+
Sbjct: 797 RKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLG 856
Query: 739 VKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPAC 798
K H + L ++ E SE + ST NL E V H +
Sbjct: 857 SKQHGITLQRRS--------ESYSEDKCDMDSTNMDSNLKPEE------VVHKEKRRTKS 902
Query: 799 QNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQV 858
+ K+ K + K + ET ++ E K + D K+K T + +
Sbjct: 903 LLEEKLVLKSKSKTQGKQVKVVET-ELQEGATKQATTPKPD-------KEKNTEENDSEK 954
Query: 859 TNEFQTVDLLIKDNGNLCDYDTQNILEL---KKYVTDRKSAEQNESKINKLRNKVNWKTE 915
+ + D ++ G + +LE + T + S+ + + + K + K + K
Sbjct: 955 QRKSKVEDKPFEETG------VEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSD-KDS 1007
Query: 916 IISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQ 975
+ + + D K ++ S +KD+ K + +++ + H EK +
Sbjct: 1008 TSTRLERKLSDGHKSRSLKHS-SKDIKKKDENKSDDKDGKEVDSSH-------EKARGNS 1059
Query: 976 ILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLK---------HI 1026
L K+ ++ + + K + KLA+ T S+ + SL+ K
Sbjct: 1060 SLMEKKLSRRLCENRRGSLSQEMAKGEEKLAAN-TLSTPSGSSLQRPKKSGDMTLIPEQE 1118
Query: 1027 TSEADSDPG--NPVELCKTQ-KQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKK-- 1081
E DS+PG N E+ KTQ ++ + D +++ Q ++ T+ SK
Sbjct: 1119 PMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATA 1178
Query: 1082 ------RKTSIDPSPESH 1093
R T ++ + E H
Sbjct: 1179 PAYKPGRGTGVNSNSEKH 1196
Score = 61.2 bits (147), Expect = 6e-09
Identities = 164/907 (18%), Positives = 347/907 (38%), Gaps = 151/907 (16%)
Query: 315 TNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSK 374
T +T+T+ +R +D+ +S + E + +++F + + T E +
Sbjct: 242 TTDTSTDKERTSEDMAD-KEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYT-KEHNN 299
Query: 375 IVTVSTGIKKKS----NKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKI- 429
++ ++ ++++S NK T++ K K ++K+E+++++F +S + +K+
Sbjct: 300 LILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVK 359
Query: 430 ------ENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQT----GF 479
E E + K + E + ++ + + ++ ++ T F
Sbjct: 360 DEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSF 419
Query: 480 EQGDRENVLC--NKKEKRITNEQEE--------TYSLSQSSGK--------FHQESKFDK 521
E+ E V+ + +E IT++ EE T + S GK H+ + K
Sbjct: 420 EEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSK 479
Query: 522 ----GQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKD 577
+ LT + + S I K +++ LL Q ++ + E E T + TK
Sbjct: 480 YYSDSDDELTVEQRRQS-----IAKEKEERLLRRQINREKLEEKRKQKAE-KTKSSKTKG 533
Query: 578 NGNLCDYGTHNILDLKKYVT-DIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKD 636
G + +DL++ T ++P + K RK + +K ++ + + ++
Sbjct: 534 QG-------RSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKV----ALSKKRKKDSRN 582
Query: 637 VVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQIT 696
V K K Q+ +E E ++ S+ + +S+ +++ ++
Sbjct: 583 VEENSK------KKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSE 636
Query: 697 NMYPVQQNESKVNKKLRQKVNRKTEIISE-VNHLDNDKSIEYTVKSHSLFLTQKDKEIIP 755
+++ V +N+++ + K T +I E V + + ++ V+ + + K+
Sbjct: 637 SLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQ--K 694
Query: 756 GNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQK 815
L++ + T +L E+++ K + P ++ K+ K + K
Sbjct: 695 STLKNEKHLKKDDSETPHLKSLLKKEVKS-SKEKPEREKTP---SEDKLSVKHK----YK 746
Query: 816 SEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNL 875
+ + +T D +H EK + EN+Q + Q L D
Sbjct: 747 GDCMHKT-----GDETELHSSEKG----------LKVEENIQ--KQSQQTKLSSDDK--- 786
Query: 876 CDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEII--SEMNQIYEDNDKDAHV 933
T+RKS +NE K++ L +E I ++ N E+N K+ +
Sbjct: 787 ---------------TERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRL 831
Query: 934 QESYTKDLDFKVNKSKQKLECQDIINKHY-----MEVNSNEKESCDQILDSYKVVKKRKK 988
TK S K++ + +K + S ++ CD +DS +
Sbjct: 832 SAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCD--MDSTNM------ 883
Query: 989 ESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQST 1048
+S+ K + ++ K K + S L E K + G V++ +T+ Q
Sbjct: 884 DSNLKPEEVVHKEKRRTKSLLEE------------KLVLKSKSKTQGKQVKVVETELQEG 931
Query: 1049 TTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKST 1108
T ++ + +K + K+RK+ ++ P +E +L++ S
Sbjct: 932 AT---------KQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETA-SSSA 981
Query: 1109 VSEQADKENN----LENEKMVKNKPDFYTKAFRSLSEIH-SPNIQDSSFDSVREGLVPLS 1163
S Q D + L EK +K T+ R LS+ H S +++ SS D ++
Sbjct: 982 HSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSD 1041
Query: 1164 VSSGKNV 1170
GK V
Sbjct: 1042 DKDGKEV 1048
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 61.2 bits (147), Expect = 6e-09
Identities = 158/836 (18%), Positives = 324/836 (38%), Gaps = 118/836 (14%)
Query: 321 EMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVST 380
E +RN L E R + ++E +L + ++ S ++++V
Sbjct: 800 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERN 859
Query: 381 GIKKKSNKKTN----EHGMKT--FRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTE 434
+++ +++ N + G+ T K K+ +K+ S+ + + D+ K E
Sbjct: 860 DAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQE 919
Query: 435 RS-------DVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGD---- 483
D + + ++ + + + + NE L + + + TL Q +
Sbjct: 920 EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLS 979
Query: 484 ---RENVLCNKKEKRITNEQEETYSLSQSSGKFHQE---SKFDKGQNSLTCNKSKASRQT 537
EN + N K + NE++ L +H + D+ Q+ + R+
Sbjct: 980 VLTAENAMLNSK---LENEKQSKERLEAEVESYHSRLAAAIHDRDQSETS------KREL 1030
Query: 538 FVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANL-STKDNGNLCDYGTHNILDLKKYV 596
+ + +D Q NL NE + L T+ N + H+ D +
Sbjct: 1031 ELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK 1090
Query: 597 TDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEP 656
T + +++K +++ + M Y++ +K + K + +E
Sbjct: 1091 T---------LGLERVQKDLSQTQCQMKEMEQKYQNEQ------VKVNKYIGKQESVEER 1135
Query: 657 ISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKV 716
+S+ + E + D N+ D + + V+ +Q Q + Q ES+ L ++
Sbjct: 1136 LSQ---LQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1192
Query: 717 NRKTEIISEVNHL-------DNDKSIEYTV---KSHSLFLTQKDKEIIPGNLEDPSEF-- 764
N+ E+ISE NHL +N+K+ V L T K + + +LE S +
Sbjct: 1193 NK--ELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRI 1250
Query: 765 ----ETPALSTK---DSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSE 817
ET L K L +++ ++ V+ MQ Q K K ++ V ++ +
Sbjct: 1251 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD 1310
Query: 818 IIPETNQIYENDNKGVHDLEK-----DNFFSLTPKDKETISENLQVTNEFQTVDLLIK-D 871
I E + N N + E+ + SL + + +N+++ E L+K
Sbjct: 1311 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1370
Query: 872 NGNLCDYDTQNILELKKYVTDRKSAE-QNESKINKLRNKVNWKT-EIISEMNQIYEDNDK 929
L +Y+ + D K+++ + + +INKL++K++ T E+ + ++ + K
Sbjct: 1371 RKKLNEYENGEF----SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK 1426
Query: 930 DAHVQESY-----TKDLDFKVNKSKQKLECQDIIN-KHYMEVN------------SNEKE 971
+ +QE + K+ K+K+KLE Q++IN + ++E N E+
Sbjct: 1427 NQILQEELLSMKTVQKKCEKLQKNKKKLE-QEVINLRSHIERNMVELGQVKQYKQEIEER 1485
Query: 972 SCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHI-TSEA 1030
+ +I + K V + + +N+ +N AS ++ LES+L I TS+
Sbjct: 1486 ARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQE 1545
Query: 1031 DSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSI 1086
D + T L K ++EE+K + K+ K + + T +
Sbjct: 1546 DF--------------NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKL 1587
Score = 43.1 bits (100), Expect = 0.002
Identities = 88/439 (20%), Positives = 178/439 (40%), Gaps = 59/439 (13%)
Query: 856 LQVTNEFQTVDLLIKDNGNLCDYDTQNI--LELKKYVTDRKSAEQNESKINKLRNKVNWK 913
L++ + + + L++ N C+ T I +E K V R+ +E E K KV W+
Sbjct: 726 LKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWE 785
Query: 914 TEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKS---------KQKLECQ-DIINKHYM 963
E+ S + ++ +K + Y K + K KQ+LE +
Sbjct: 786 RELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELR 845
Query: 964 EVNSNEKESCDQILDSYKVVKKRKKESSCK---AKNILTKAKNKLASQLTESSQTSIS-- 1018
V SN + + D+ + + + + + N L+K K +Q +S+ S S
Sbjct: 846 TVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 905
Query: 1019 LESDLKHITSEADSDPGN---PVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKM 1075
E DL H S + ++ K Q Q +K+ E++K VK+ N+
Sbjct: 906 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLK----IVKEKNED 955
Query: 1076 TSKSKKRKTSIDPSPESHEVMERILDSVQGKSTV--SEQADKENNLENEKMVKNKPDFYT 1133
K+ K ++ E + + + G+ +V +E A + LENEK K + +
Sbjct: 956 LQKTIK---------QNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEV 1006
Query: 1134 KAFRS--LSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSD--D 1189
+++ S + IH +D S S RE + L+ ++ E L+ F VS+ D
Sbjct: 1007 ESYHSRLAAAIHD---RDQSETSKRE--LELAFQRARD----ECSRLQDKMNFDVSNLKD 1057
Query: 1190 EHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSF-----VSNNTAESENKSEDLSSERTS 1244
+E +++ FK + I +D V + ++++ + +++ + +
Sbjct: 1058 NNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQN 1117
Query: 1245 RRRRCTPFYFKEPSLRDKM 1263
+ + + K+ S+ +++
Sbjct: 1118 EQVKVNKYIGKQESVEERL 1136
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 60.1 bits (144), Expect = 1e-08
Identities = 85/442 (19%), Positives = 188/442 (42%), Gaps = 58/442 (13%)
Query: 733 KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGH 792
K + ++SH + L I+ G +E + + + D G L +++++G +
Sbjct: 207 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGML--EYLEDIIGCGRLN 264
Query: 793 DMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETI 852
+ P +C++ EI+ N+++G EK N + K+K+ +
Sbjct: 265 E--------------PIKVLCRRVEIL--------NEHRG----EKLNRVKMVEKEKDAL 298
Query: 853 SENLQVTNEFQTVDL-LIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVN 911
+ EF T++ + + ++C Y I EL+K + + E + KI++ ++N
Sbjct: 299 EGEKNIAIEFLTLENEIFRKKNHVCQY---YIYELQKRIAEM---ETQKEKIHEDTKEIN 352
Query: 912 WKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQK---LECQDIINKHYMEVNSN 968
K+ I+S N++ N KD E + + ++K+K L+ +D+ + ++ ++
Sbjct: 353 EKSNILS--NEMKAKN-KDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATS 409
Query: 969 EKESCDQILDSYKVVKKRKKESSCKAKNIL--TKAKNKLASQLTESSQTSI-----SLES 1021
+ + ++ L K + K K+ NI+ T +N + E + + SL+
Sbjct: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQ 469
Query: 1022 DLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKK 1081
+ + + E +S EL K +K D+ E + + + N S+ K
Sbjct: 470 ETQGLQKEKES---REKELMGFSKSVNEARSKMDVAQ----SELDIYLSRHNTAVSQLTK 522
Query: 1082 RKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYT---KAFRS 1138
K ++ + E+ + + + ++GK +EQ KE E +K+ + + +F + F+
Sbjct: 523 AKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQK 582
Query: 1139 LSEIHSPNIQDSSFDSVREGLV 1160
+ E S + S V + ++
Sbjct: 583 VEEAKSSLAMNRSRGKVLDAII 604
Score = 35.8 bits (81), Expect = 0.27
Identities = 53/212 (25%), Positives = 97/212 (45%), Gaps = 42/212 (19%)
Query: 542 KLEKDNLLPNQKDKVTIYENLDVTNEFHTA-NLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
KL + ++ +KD + +N+ + EF T N + ++C Y I +L+K + ++
Sbjct: 284 KLNRVKMVEKEKDALEGEKNIAI--EFLTLENEIFRKKNHVCQY---YIYELQKRIAEM- 337
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
E + I++ K++N K+ I+S N M N KDV KK N K I EN
Sbjct: 338 --ETQKEKIHEDTKEINEKSNILS--NEMKAKN-KDVKDTEKKLNKITKF------IEEN 386
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
E +L + + R+ + + T L+KQ+ +K ++KV
Sbjct: 387 KEKFTQLDLEDVQVRE---KLKHATSKAKKLEKQL--------------QKDKEKVEEFK 429
Query: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKE 752
I ++ N++ N E T ++++L +K+KE
Sbjct: 430 SIPAKSNNIIN----ETTTRNNAL---EKEKE 454
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 60.1 bits (144), Expect = 1e-08
Identities = 85/442 (19%), Positives = 188/442 (42%), Gaps = 58/442 (13%)
Query: 733 KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGH 792
K + ++SH + L I+ G +E + + + D G L +++++G +
Sbjct: 207 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGML--EYLEDIIGCGRLN 264
Query: 793 DMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETI 852
+ P +C++ EI+ N+++G EK N + K+K+ +
Sbjct: 265 E--------------PIKVLCRRVEIL--------NEHRG----EKLNRVKMVEKEKDAL 298
Query: 853 SENLQVTNEFQTVDL-LIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVN 911
+ EF T++ + + ++C Y I EL+K + + E + KI++ ++N
Sbjct: 299 EGEKNIAIEFLTLENEIFRKKNHVCQY---YIYELQKRIAEM---ETQKEKIHEDTKEIN 352
Query: 912 WKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQK---LECQDIINKHYMEVNSN 968
K+ I+S N++ N KD E + + ++K+K L+ +D+ + ++ ++
Sbjct: 353 EKSNILS--NEMKAKN-KDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATS 409
Query: 969 EKESCDQILDSYKVVKKRKKESSCKAKNIL--TKAKNKLASQLTESSQTSI-----SLES 1021
+ + ++ L K + K K+ NI+ T +N + E + + SL+
Sbjct: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQ 469
Query: 1022 DLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKK 1081
+ + + E +S EL K +K D+ E + + + N S+ K
Sbjct: 470 ETQGLQKEKES---REKELMGFSKSVNEARSKMDVAQ----SELDIYLSRHNTAVSQLTK 522
Query: 1082 RKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYT---KAFRS 1138
K ++ + E+ + + + ++GK +EQ KE E +K+ + + +F + F+
Sbjct: 523 AKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQK 582
Query: 1139 LSEIHSPNIQDSSFDSVREGLV 1160
+ E S + S V + ++
Sbjct: 583 VEEAKSSLAMNRSRGKVLDAII 604
Score = 35.8 bits (81), Expect = 0.27
Identities = 53/212 (25%), Positives = 97/212 (45%), Gaps = 42/212 (19%)
Query: 542 KLEKDNLLPNQKDKVTIYENLDVTNEFHTA-NLSTKDNGNLCDYGTHNILDLKKYVTDIQ 600
KL + ++ +KD + +N+ + EF T N + ++C Y I +L+K + ++
Sbjct: 284 KLNRVKMVEKEKDALEGEKNIAI--EFLTLENEIFRKKNHVCQY---YIYELQKRIAEM- 337
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
E + I++ K++N K+ I+S N M N KDV KK N K I EN
Sbjct: 338 --ETQKEKIHEDTKEINEKSNILS--NEMKAKN-KDVKDTEKKLNKITKF------IEEN 386
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT 720
E +L + + R+ + + T L+KQ+ +K ++KV
Sbjct: 387 KEKFTQLDLEDVQVRE---KLKHATSKAKKLEKQL--------------QKDKEKVEEFK 429
Query: 721 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKE 752
I ++ N++ N E T ++++L +K+KE
Sbjct: 430 SIPAKSNNIIN----ETTTRNNAL---EKEKE 454
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 59.3 bits (142), Expect = 2e-08
Identities = 168/857 (19%), Positives = 338/857 (39%), Gaps = 109/857 (12%)
Query: 260 RRWEKPSPSNVTERKKRG---SSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTN 316
+R +K ER+K+G + E A + + + + + +NE+N
Sbjct: 576 KRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAK 635
Query: 317 E----------TNTEMQRNKQDLPGLSSESAREPNAECMNQIE---DNDDFQLQKTVYDA 363
+ + +E+++ K++L + ++ A+ E Q++ + +L K + +
Sbjct: 636 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITEL 695
Query: 364 DM--DLTASEVSKIVTVSTGIKKKSNKKTNEHGMKT-FRKVKDSSSEKKRERSKRQFKNS 420
+ E+ K+ + +K++++ T E MK + +K S KK + N
Sbjct: 696 TLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE--MKNHYVPLKVSEDMKKSHDAIIDDLNR 753
Query: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKK--MTLQTG 478
+D+ +K E+ +M + L + + L K L+T
Sbjct: 754 KLLDVTQKY------------------------TEKKLEMEKLLLENDSLSKDVSRLETV 789
Query: 479 FEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTF 538
F ++ + I +++ L + G+ ++ +N T K S Q
Sbjct: 790 FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN--TNLKKMMSNQYV 847
Query: 539 VIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTAN---LSTKDNGNLCDYGTHNILDLKK- 594
+ E+ + N T E LDV +F N + KD + N + K
Sbjct: 848 PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 907
Query: 595 -YVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQED 653
Y++ + + S +RK + EI++ Y +++V + +
Sbjct: 908 EYISLAEHEAKMSSLSQSMRKVQDSNAEILAN----YRKGQEEIV------TLHAEIKAQ 957
Query: 654 KEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLR 713
K+ + E K P +S + E + + + + T Y V + E K NK+
Sbjct: 958 KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1017
Query: 714 QKVNRKTEIISEVNHLDNDKSIEYTVKSHSL--FLTQKDKEIIPGNLEDPSEFETPALST 771
K+ K EI + L DK++ KSH + L++K E+ L+D S+ T +
Sbjct: 1018 DKL--KKEIFTLQKDL-RDKTV-LIEKSHEMERALSRKTDELNK-QLKDLSQKYTEVKNV 1072
Query: 772 KDS----GNLYDSEI---QNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQ 824
K+ SEI QN+L +H Q S G L E + +
Sbjct: 1073 KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLK-----EELKSMQR 1127
Query: 825 IYENDNKGV---HDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQ 881
YE + + V H L ++ S P ++E+LQ+ F+ +IK + + ++Q
Sbjct: 1128 CYEKEQQTVTKLHQLLENQKNSSVP-----LAEHLQIKEAFEKEVGIIKASLREKEEESQ 1182
Query: 882 NILE-LKKYVTDRKSAEQNESKIN--KLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYT 938
N +E + K ++ ++ +Q K+ ++ + +K QI N+K A++ Y
Sbjct: 1183 NKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYE 1242
Query: 939 KDLDFKVNKSKQKLECQD---IINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAK 995
+ + ++ K+++ +D +++ + ++KE CD+ L + +++R +ES AK
Sbjct: 1243 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES---AK 1299
Query: 996 NILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKD 1055
I K NK+ L + + +L S+ GNP K Q Q TL +
Sbjct: 1300 QIEAK-DNKITELLNDVERLKQALNG-----LSQLTYTSGNPT---KRQSQLIDTLQHQV 1350
Query: 1056 LPFVEEIKEGECQVKKV 1072
+++ + + Q ++V
Sbjct: 1351 KSLEQQLADADRQHQEV 1367
Score = 39.7 bits (91), Expect = 0.018
Identities = 87/466 (18%), Positives = 193/466 (41%), Gaps = 51/466 (10%)
Query: 691 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD 750
LQK+++ + K +K+ + + E+ +++ + E S S + +K
Sbjct: 578 LQKELSMC---EMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKA 634
Query: 751 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL 810
K+++ E ++ N+ Q+V +H Q ++GKK
Sbjct: 635 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE 694
Query: 811 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKE-----TISENLQVTNEFQTV 865
+ + E ++Y DNK L K+ +LT + K +SE+++ +++
Sbjct: 695 LTLKNQTLQKEIEKVYL-DNK----LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 749
Query: 866 DLLIKDNGNLCDYD---TQNILELKKYVTDRKSAEQNESKINKLR-NKVNWKTEIISEMN 921
DL N L D T+ LE++K + + S ++ S++ + + EII+ +
Sbjct: 750 DL----NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 805
Query: 922 QIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNE--KESCDQIL-- 977
I E + + +++ +D + + + + +++ Y+ V ++E K + + L
Sbjct: 806 NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865
Query: 978 DSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE-----------SDLKHI 1026
+ +++ +KK + + K KN++ + E++Q I E S L
Sbjct: 866 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 925
Query: 1027 TSEADSDPGNPVELCKTQKQSTTTLN------KKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
+ + + ++ TL+ KK+L ++E +VK ++ +
Sbjct: 926 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC----IKVKYAPIVSFEEC 981
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVK 1126
+RK E+ +++ + Q K +VSE+ K+N EN+K+ K
Sbjct: 982 ERKFKATEK----ELKDQLSEQTQ-KYSVSEEEVKKNKQENDKLKK 1022
Score = 38.1 bits (87), Expect = 0.054
Identities = 136/653 (20%), Positives = 254/653 (38%), Gaps = 136/653 (20%)
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKG--NFFFKTQEDKEPIS 658
P+E+ E+ + L +VN K + + M +E + ++ LK+ N K + +P
Sbjct: 615 PAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI-RQLKRELENVKAKLAQHVKP-E 672
Query: 659 ENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR 718
E+ +V L+ + + + Q LQK+I +Y NK L+++ +
Sbjct: 673 EHEQVKSRLEQKSGELGKKITELTLKNQT---LQKEIEKVY-------LDNKLLKEQAHN 722
Query: 719 KTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGN---LEDPSEFETPALSTKDSG 775
T I NH K E KSH + +++++ E E E L DS
Sbjct: 723 LT--IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN-DSL 779
Query: 776 NLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHD 835
+ S ++ V H+ + + KS I+ Q+ E K D
Sbjct: 780 SKDVSRLETVFVPPEKHEKEI---------------IALKSNIVELKKQLSELKKKCGED 824
Query: 836 LEKDNFFSLTPKD---KETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTD 892
EK +LT ++ K+ +S + V + + D + +L++KK D
Sbjct: 825 QEK--IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDT---LAKTNRELLDVKKKFED 879
Query: 893 R-----KSAEQNESKINKLRNKVNW-KTEIIS------EMNQIYED----NDKDAHVQES 936
K ++NE L N N K E IS +M+ + + D +A + +
Sbjct: 880 INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILAN 939
Query: 937 YTKD------LDFKVNKSKQKLEC-QDIINKHYMEVNS----------NEKESCDQILD- 978
Y K L ++ K++L+ Q+ I Y + S EKE DQ+ +
Sbjct: 940 YRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQ 999
Query: 979 ------SYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADS 1032
S + VKK K+E+ K I T L+ DL+ T +
Sbjct: 1000 TQKYSVSEEEVKKNKQENDKLKKEIFT-------------------LQKDLRDKTVLIEK 1040
Query: 1033 DPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPES 1092
E+ + + T LNK+ ++++ + +VK V + + ++TS
Sbjct: 1041 SH----EMERALSRKTDELNKQ----LKDLSQKYTEVKNVKEKLVEENAKQTS------- 1085
Query: 1093 HEVMERILDSVQGKSTVSEQADK-----ENNLEN-EKMVKNKPDFYTKAFRSLSEIHSPN 1146
E++ + + +Q + EQ + +EN ++ +K+ Y K ++++++H
Sbjct: 1086 -EIL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH--- 1140
Query: 1147 IQDSSFDSVREGLVPLSVSSGKNVIIKENFALECS-PAFQVSDDEHEKMNKMK 1198
++ + VPL+ +++ IKE F E + + E E NKM+
Sbjct: 1141 ---QLLENQKNSSVPLA----EHLQIKEAFEKEVGIIKASLREKEEESQNKME 1186
Score = 37.0 bits (84), Expect = 0.12
Identities = 59/285 (20%), Positives = 118/285 (41%), Gaps = 42/285 (14%)
Query: 878 YDTQNIL--ELKKYVTDRKSAEQNESKI-NKLRNKVNWKTEIISEMNQIYEDNDKDAHVQ 934
Y IL EL+ T +SA+Q+ K+ N+L +KV + E ++ ED+D+
Sbjct: 423 YSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL 482
Query: 935 ESYTKDLDFKVNKSKQKLECQD----IINKHY-MEVNSNEKESCDQILDSYKVVKKRKKE 989
E KD+ ++ +S+ K++ + +H E S +++ D K +K + +
Sbjct: 483 EDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEG 542
Query: 990 SSCKAKNI--------------------LTKAKNKLASQLT-------ESSQTSISLESD 1022
+S + + L + +L +L+ + + +E
Sbjct: 543 ASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQ 602
Query: 1023 LKHITSE-ADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVN--KMTSKS 1079
K ++++ A S P E K+ + +N+K VE +E E + ++ K ++
Sbjct: 603 AKELSAKLALSIPAEKFENMKS--SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELEN 660
Query: 1080 KKRKTSIDPSPESHEVMERILDSVQGK--STVSEQADKENNLENE 1122
K K + PE HE ++ L+ G+ ++E K L+ E
Sbjct: 661 VKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 705
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 59.3 bits (142), Expect = 2e-08
Identities = 168/857 (19%), Positives = 338/857 (39%), Gaps = 109/857 (12%)
Query: 260 RRWEKPSPSNVTERKKRG---SSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTN 316
+R +K ER+K+G + E A + + + + + +NE+N
Sbjct: 589 KRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAK 648
Query: 317 E----------TNTEMQRNKQDLPGLSSESAREPNAECMNQIE---DNDDFQLQKTVYDA 363
+ + +E+++ K++L + ++ A+ E Q++ + +L K + +
Sbjct: 649 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITEL 708
Query: 364 DM--DLTASEVSKIVTVSTGIKKKSNKKTNEHGMKT-FRKVKDSSSEKKRERSKRQFKNS 420
+ E+ K+ + +K++++ T E MK + +K S KK + N
Sbjct: 709 TLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE--MKNHYVPLKVSEDMKKSHDAIIDDLNR 766
Query: 421 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKK--MTLQTG 478
+D+ +K E+ +M + L + + L K L+T
Sbjct: 767 KLLDVTQKY------------------------TEKKLEMEKLLLENDSLSKDVSRLETV 802
Query: 479 FEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTF 538
F ++ + I +++ L + G+ ++ +N T K S Q
Sbjct: 803 FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN--TNLKKMMSNQYV 860
Query: 539 VIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTAN---LSTKDNGNLCDYGTHNILDLKK- 594
+ E+ + N T E LDV +F N + KD + N + K
Sbjct: 861 PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 920
Query: 595 -YVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQED 653
Y++ + + S +RK + EI++ Y +++V + +
Sbjct: 921 EYISLAEHEAKMSSLSQSMRKVQDSNAEILAN----YRKGQEEIV------TLHAEIKAQ 970
Query: 654 KEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLR 713
K+ + E K P +S + E + + + + T Y V + E K NK+
Sbjct: 971 KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1030
Query: 714 QKVNRKTEIISEVNHLDNDKSIEYTVKSHSL--FLTQKDKEIIPGNLEDPSEFETPALST 771
K+ K EI + L DK++ KSH + L++K E+ L+D S+ T +
Sbjct: 1031 DKL--KKEIFTLQKDL-RDKTV-LIEKSHEMERALSRKTDELNK-QLKDLSQKYTEVKNV 1085
Query: 772 KDS----GNLYDSEI---QNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQ 824
K+ SEI QN+L +H Q S G L E + +
Sbjct: 1086 KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLK-----EELKSMQR 1140
Query: 825 IYENDNKGV---HDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQ 881
YE + + V H L ++ S P ++E+LQ+ F+ +IK + + ++Q
Sbjct: 1141 CYEKEQQTVTKLHQLLENQKNSSVP-----LAEHLQIKEAFEKEVGIIKASLREKEEESQ 1195
Query: 882 NILE-LKKYVTDRKSAEQNESKIN--KLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYT 938
N +E + K ++ ++ +Q K+ ++ + +K QI N+K A++ Y
Sbjct: 1196 NKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYE 1255
Query: 939 KDLDFKVNKSKQKLECQD---IINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAK 995
+ + ++ K+++ +D +++ + ++KE CD+ L + +++R +ES AK
Sbjct: 1256 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES---AK 1312
Query: 996 NILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKD 1055
I K NK+ L + + +L S+ GNP K Q Q TL +
Sbjct: 1313 QIEAK-DNKITELLNDVERLKQALNG-----LSQLTYTSGNPT---KRQSQLIDTLQHQV 1363
Query: 1056 LPFVEEIKEGECQVKKV 1072
+++ + + Q ++V
Sbjct: 1364 KSLEQQLADADRQHQEV 1380
Score = 39.7 bits (91), Expect = 0.018
Identities = 87/466 (18%), Positives = 193/466 (41%), Gaps = 51/466 (10%)
Query: 691 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD 750
LQK+++ + K +K+ + + E+ +++ + E S S + +K
Sbjct: 591 LQKELSMC---EMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKA 647
Query: 751 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL 810
K+++ E ++ N+ Q+V +H Q ++GKK
Sbjct: 648 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE 707
Query: 811 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKE-----TISENLQVTNEFQTV 865
+ + E ++Y DNK L K+ +LT + K +SE+++ +++
Sbjct: 708 LTLKNQTLQKEIEKVYL-DNK----LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
Query: 866 DLLIKDNGNLCDYD---TQNILELKKYVTDRKSAEQNESKINKLR-NKVNWKTEIISEMN 921
DL N L D T+ LE++K + + S ++ S++ + + EII+ +
Sbjct: 763 DL----NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 922 QIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNE--KESCDQIL-- 977
I E + + +++ +D + + + + +++ Y+ V ++E K + + L
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878
Query: 978 DSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE-----------SDLKHI 1026
+ +++ +KK + + K KN++ + E++Q I E S L
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 1027 TSEADSDPGNPVELCKTQKQSTTTLN------KKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
+ + + ++ TL+ KK+L ++E +VK ++ +
Sbjct: 939 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC----IKVKYAPIVSFEEC 994
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVK 1126
+RK E+ +++ + Q K +VSE+ K+N EN+K+ K
Sbjct: 995 ERKFKATEK----ELKDQLSEQTQ-KYSVSEEEVKKNKQENDKLKK 1035
Score = 38.1 bits (87), Expect = 0.054
Identities = 136/653 (20%), Positives = 254/653 (38%), Gaps = 136/653 (20%)
Query: 601 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKG--NFFFKTQEDKEPIS 658
P+E+ E+ + L +VN K + + M +E + ++ LK+ N K + +P
Sbjct: 628 PAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI-RQLKRELENVKAKLAQHVKP-E 685
Query: 659 ENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR 718
E+ +V L+ + + + Q LQK+I +Y NK L+++ +
Sbjct: 686 EHEQVKSRLEQKSGELGKKITELTLKNQT---LQKEIEKVY-------LDNKLLKEQAHN 735
Query: 719 KTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGN---LEDPSEFETPALSTKDSG 775
T I NH K E KSH + +++++ E E E L DS
Sbjct: 736 LT--IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN-DSL 792
Query: 776 NLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHD 835
+ S ++ V H+ + + KS I+ Q+ E K D
Sbjct: 793 SKDVSRLETVFVPPEKHEKEI---------------IALKSNIVELKKQLSELKKKCGED 837
Query: 836 LEKDNFFSLTPKD---KETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTD 892
EK +LT ++ K+ +S + V + + D + +L++KK D
Sbjct: 838 QEK--IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDT---LAKTNRELLDVKKKFED 892
Query: 893 R-----KSAEQNESKINKLRNKVNW-KTEIIS------EMNQIYED----NDKDAHVQES 936
K ++NE L N N K E IS +M+ + + D +A + +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Query: 937 YTKD------LDFKVNKSKQKLEC-QDIINKHYMEVNS----------NEKESCDQILD- 978
Y K L ++ K++L+ Q+ I Y + S EKE DQ+ +
Sbjct: 953 YRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQ 1012
Query: 979 ------SYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADS 1032
S + VKK K+E+ K I T L+ DL+ T +
Sbjct: 1013 TQKYSVSEEEVKKNKQENDKLKKEIFT-------------------LQKDLRDKTVLIEK 1053
Query: 1033 DPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPES 1092
E+ + + T LNK+ ++++ + +VK V + + ++TS
Sbjct: 1054 SH----EMERALSRKTDELNKQ----LKDLSQKYTEVKNVKEKLVEENAKQTS------- 1098
Query: 1093 HEVMERILDSVQGKSTVSEQADK-----ENNLEN-EKMVKNKPDFYTKAFRSLSEIHSPN 1146
E++ + + +Q + EQ + +EN ++ +K+ Y K ++++++H
Sbjct: 1099 -EIL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH--- 1153
Query: 1147 IQDSSFDSVREGLVPLSVSSGKNVIIKENFALECS-PAFQVSDDEHEKMNKMK 1198
++ + VPL+ +++ IKE F E + + E E NKM+
Sbjct: 1154 ---QLLENQKNSSVPLA----EHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Score = 37.0 bits (84), Expect = 0.12
Identities = 59/285 (20%), Positives = 118/285 (41%), Gaps = 42/285 (14%)
Query: 878 YDTQNIL--ELKKYVTDRKSAEQNESKI-NKLRNKVNWKTEIISEMNQIYEDNDKDAHVQ 934
Y IL EL+ T +SA+Q+ K+ N+L +KV + E ++ ED+D+
Sbjct: 436 YSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL 495
Query: 935 ESYTKDLDFKVNKSKQKLECQD----IINKHY-MEVNSNEKESCDQILDSYKVVKKRKKE 989
E KD+ ++ +S+ K++ + +H E S +++ D K +K + +
Sbjct: 496 EDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEG 555
Query: 990 SSCKAKNI--------------------LTKAKNKLASQLT-------ESSQTSISLESD 1022
+S + + L + +L +L+ + + +E
Sbjct: 556 ASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQ 615
Query: 1023 LKHITSE-ADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVN--KMTSKS 1079
K ++++ A S P E K+ + +N+K VE +E E + ++ K ++
Sbjct: 616 AKELSAKLALSIPAEKFENMKS--SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELEN 673
Query: 1080 KKRKTSIDPSPESHEVMERILDSVQGK--STVSEQADKENNLENE 1122
K K + PE HE ++ L+ G+ ++E K L+ E
Sbjct: 674 VKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 718
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 57.8 bits (138), Expect = 7e-08
Identities = 148/718 (20%), Positives = 295/718 (41%), Gaps = 96/718 (13%)
Query: 356 LQKTVYDADMDL-----TASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKR 410
LQKT+Y + L E+ + S K K+ +E G + R ++ + S+ ++
Sbjct: 428 LQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-RNLESTVSQIEK 486
Query: 411 ER-------SKRQFKNSSDVDIGEKIENR--TERSDVLDGKRGAEDPGFIFNNEQLAQMN 461
E+ ++ Q K + + +EN T + + D K+ +++ NE+L+Q+
Sbjct: 487 EKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLA--NEKLSQLQ 544
Query: 462 EQLAQVNELKKMTLQTG--FEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKF 519
+QL + N+L + T + E + + + E +E + ++S K + +
Sbjct: 545 KQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENS-KSQTDKDY 603
Query: 520 DKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLD-VTNEFHTA----NLS 574
+ Q L + + +I L+ + Q++ + NL+ V E A N S
Sbjct: 604 YQLQAILEAERRDRGHDSEMIGDLQA-RITSLQEEVKHLKHNLEKVEGERKEAQDMLNHS 662
Query: 575 TKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDND 634
K+ NL +DL + +Q + E N +K+ K R T+ H +
Sbjct: 663 EKEKNNL-------EIDLNYKLKSLQQRLEQEVNEHKVTKA--RLTD-----KHQSIEEA 708
Query: 635 KDVVHGLKKGNFFFKTQEDKEPISEN--IEVSKELQIPALSTRDNENQCDYRTQNVLGLQ 692
K V + + K + + +EN +++ K+ + + + ++ + ++ T N ++
Sbjct: 709 KSV--AMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERME 766
Query: 693 KQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKE 752
++ N+ Q E + NK+L + KT+ DN K +E +K L + +
Sbjct: 767 DEVKNL--TLQLEQESNKRLLLQNELKTQAF----EADNLKGLEKQMKQEINTLLEAKRL 820
Query: 753 IIPGNLEDPSEFETPALSTKDSGNLYD-SEIQNVLGVKHGHDMQPACQ---NDSKIGKKP 808
+ EFE L+ + GN E+Q+ L + Q +I +K
Sbjct: 821 L---------EFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKN 871
Query: 809 RLNVCQKSEI------------IPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENL 856
R N+ + E+ + ET E +G L ++ +F LT + K+ S N
Sbjct: 872 RENLKKIQELQNEKETLATQLDLAETKAESEQLARG---LLEEQYFELTQESKKAASRNR 928
Query: 857 Q-VTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTE 915
Q +T++ TV L + N L D + + + +T++ + E K+ K N K
Sbjct: 929 QEITDKDHTVSRLEEANSMLTK-DIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAA 987
Query: 916 IISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSK---QKLECQDIINKHYMEVNSNEKES 972
+N + + DFK+++ K Q L ++ N+ + E+E
Sbjct: 988 FEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREK 1047
Query: 973 CDQILDSYKVVKKRKKESSCKAKNILTKA-KNKLASQLTESSQTSISLESDLKHITSE 1029
+Q+ VVK +K+ + +A+ + A +N+L QL S ESD++ + ++
Sbjct: 1048 FNQM-----VVKHQKELNDMQAQLVEECAHRNELQMQLA-------SKESDIEQLRAK 1093
Score = 37.7 bits (86), Expect = 0.070
Identities = 112/653 (17%), Positives = 262/653 (40%), Gaps = 77/653 (11%)
Query: 587 HNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNF 646
HN + LK + Q + ++K+ K+++ + + +K+ + + N
Sbjct: 440 HNEMQLKDEME--QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINE 497
Query: 647 FFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG-LQKQITNMYPVQQNE 705
+ + E + N+E L +Q L LQKQ+ + + E
Sbjct: 498 YQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE 557
Query: 706 SKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFE 765
S +LR+ ++ IS++ L+ + + +S T KD + LE
Sbjct: 558 SDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILE------ 611
Query: 766 TPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQI 825
+D G +DSE+ D+Q + + K + N+ + E +
Sbjct: 612 ---AERRDRG--HDSEMIG--------DLQARITSLQEEVKHLKHNLEKVEGERKEAQDM 658
Query: 826 YENDNKGVHDLEKDNFFSLTPKDKETISENL-QVTNEFQTVDLLIKD-NGNLCDYDTQNI 883
+ K ++LE D + L +++ + L Q NE + + D + ++ + + +
Sbjct: 659 LNHSEKEKNNLEIDLNYKL-----KSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAM 713
Query: 884 LEL-KKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLD 942
E+ KK +R++ E+ E+++ ++ + + + + Q E + E K+L
Sbjct: 714 CEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT 773
Query: 943 FKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAK 1002
++ + NK + N + ++ + D+ K ++K+ K+ N L +AK
Sbjct: 774 LQLEQES---------NKRLLLQNELKTQAFE--ADNLKGLEKQMKQEI----NTLLEAK 818
Query: 1003 NKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQ----KQSTTTLNKKDLPF 1058
L +L + ++ E ++ + + +++ L KTQ K+ N+++L
Sbjct: 819 RLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFST-LYKTQVKELKEEIEEKNRENLKK 877
Query: 1059 VEEIKEGE---------CQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKS-T 1108
++E++ + + K ++ ++ + + + ES + R + K T
Sbjct: 878 IQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHT 937
Query: 1109 VS--EQAD-----------KENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSV 1155
VS E+A+ +EN EKM K + ++ + +S + + ++ + +
Sbjct: 938 VSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERT 997
Query: 1156 REGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMN-KMKFKVNRRTQK 1207
L +V+ ++ +++F ++ A + EK N K++ ++N+ +K
Sbjct: 998 ---LKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREK 1047
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.4 bits (137), Expect = 9e-08
Identities = 140/779 (17%), Positives = 303/779 (38%), Gaps = 99/779 (12%)
Query: 16 IKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRI 75
++R L+ + + +++SL +I + + + + + +L + +E ++
Sbjct: 483 LRRRLESNKPAGDVDMSLSLLQEISS-LQEKLEVTRTDHQREITSLKEHFGAREETHQK- 540
Query: 76 TTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAI-----EMSSLSEF 130
E L EKL+ EN L+ KL + NK+ D+ AL + L TAI M L
Sbjct: 541 --EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 598
Query: 131 HQSSFLLSASKKKRISKQCKLMRLPFA-RVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIP 189
++ + Q + MRL + + N + E + +++K + I
Sbjct: 599 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 658
Query: 190 SSGSTTQPL-STQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSL 248
++ + + S D +E L E + L ++E + ++ ++ + +
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE--IKVKELEVLQAKCNEQTKVIDNF 716
Query: 249 MSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCN 308
S+++ + EK + + E L A ++ I E+ N
Sbjct: 717 TSQLKATE------EKLLDLDALRKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKN 766
Query: 309 NEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQ---KTVYDADM 365
E + + E+Q + L L + N ++Q+++ + +LQ + +A
Sbjct: 767 AE-SSKASSITRELQGRELKLTNL------QENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 366 DLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDI 425
+ + + S TV+ +K+ ++ R+ K RE+ +R+ +
Sbjct: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE---EQLIKA 876
Query: 426 GEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRE 485
EK+EN D+ + + + D N+ QL +MN++L ++ E LQ + +
Sbjct: 877 KEKLEN-----DIAEIMKMSGD-----NSSQLTKMNDEL-RLKERDVEELQLKLTKANEN 925
Query: 486 NVLCNKKEKRITNEQEETYSLSQSSGKFHQ-------------ESKFDKGQNSLTCNKSK 532
K + +T + E++ Q + K H+ E K + N K++
Sbjct: 926 ASFLQKSIEDMTVKAEQS---QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
Query: 533 ASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDL 592
R T K + + +L N + + LD ++ A ++N L + +L
Sbjct: 983 YERATSET-KTKHEEILQNLQKTL-----LDTEDKLKGAR---EENSGL----LQELEEL 1029
Query: 593 KKYVTDIQPSEQNESNINKLRKKVNRKTEIISG--------------MNHMYEDNDKDVV 638
+K + ++ E + + + KTE ++ ++ + E+N K+V
Sbjct: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
Query: 639 HGLKKGNFFFKTQEDKEPISENIEVSKEL---QIPALSTRDNENQCDYRTQNVLGLQK-Q 694
K + E + IE K+ + LS EN + LG + +
Sbjct: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEEN---VKLAEELGRSRDE 1146
Query: 695 ITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEI 753
+T+ +++ S +N +L + R+++ I + + + S++ ++ S LT+KD E+
Sbjct: 1147 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD--EEKASLQKSISITSALLTEKDAEL 1203
Score = 51.6 bits (122), Expect = 5e-06
Identities = 157/844 (18%), Positives = 303/844 (35%), Gaps = 169/844 (20%)
Query: 335 ESAREPNAECMNQIEDN----DDFQL---QKTVYDADMDL-TASEVSKIVTVSTGI---- 382
E+A E +NQ+E+ +D Q ++++ D+++ T SE S+I+ + +
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRV 477
Query: 383 --------KKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTE 434
+ +SNK + M + SS ++K E ++ D +I + E
Sbjct: 478 QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR--------TDHQREITSLKE 529
Query: 435 RSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEK 494
+ E E+L++ NE L K E D + +K E
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESL------KSKLEHANKENSDVIALWKSKLET 583
Query: 495 RITNEQE--ETYSLSQSSGKFHQESKFDK------------------------GQNSLTC 528
I + Q+ E +S S G + ++F + + +
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 529 NKSKASRQTFVIHKLEKDNLLPNQKDKVT------IYENLDVTNEFHTANLSTKDNGNLC 582
+ +A R + EK+N L + K+ + E D N+ A + K+ L
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 583 DYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVH--- 639
+ + + ++ +E+ +++ LRK + + + E +K + H
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 640 -------------------GLKKGNF---FFKTQEDKEPISENIEVSKELQIPALSTRDN 677
LK N + + KE + + +++ KE A +
Sbjct: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 678 ENQCDYRTQNVLGLQKQITNMYP-----VQQNESKVNKKLRQKVNRKTEIISEVNHLDND 732
+ T N L +++ NM +++N + + K R+K R+ ++I L+ND
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 733 ----------KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEI 782
S + T + L L ++D E + L +E + + + + +
Sbjct: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943
Query: 783 QNVLGVKHGHDMQPACQNDSKIGKKPRL--NVCQKSEIIPETNQIYENDNKGVHDLEKDN 840
Q KH + + + S + KK N CQ E YE
Sbjct: 944 QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ------ELKARYERAT---------- 987
Query: 841 FFSLTPKDKETISENLQVTNEFQTVDLLI---KDNGNLCDYDTQNILELKKYVTDRKSAE 897
S T E I +NLQ T T D L ++N L Q + EL+K K+A+
Sbjct: 988 --SETKTKHEEILQNLQKTL-LDTEDKLKGAREENSGLL----QELEELRKQADKAKAAQ 1040
Query: 898 QNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAH----VQESYTKDLDFKVNKSKQKLE 953
E + + KTE ++ + + N K + ++E+ K+++ ++NKSK+ L
Sbjct: 1041 TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELL- 1098
Query: 954 CQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESS 1013
V+ +K E K L +A + + QL+
Sbjct: 1099 ----------------------------TVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1130
Query: 1014 QTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVN 1073
+ ++ L +L E S E Q + K++ F+++ E + ++K
Sbjct: 1131 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ-LLEMKKRESKFIKDADEEKASLQKSI 1189
Query: 1074 KMTS 1077
+TS
Sbjct: 1190 SITS 1193
Score = 39.7 bits (91), Expect = 0.018
Identities = 102/472 (21%), Positives = 197/472 (41%), Gaps = 72/472 (15%)
Query: 781 EIQNVLGV-KHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLE-K 838
EI+ L + + GHD Q + ++K+ + + E + NQ+ E K V DL+ +
Sbjct: 387 EIEQELALARDGHD-QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK-VEDLQFR 444
Query: 839 DNFFSLTPKDKE--TISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSA 896
S+T D E T+SE ++ + + L +++ L + LE K D +
Sbjct: 445 VEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAEL-----RRRLESNKPAGDVDMS 499
Query: 897 EQNESKINKLRNKVN-WKTEIISEMNQIYED-------NDKDAHVQESYTKDLDFKVNKS 948
+I+ L+ K+ +T+ E+ + E + K+ + T+ L +
Sbjct: 500 LSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559
Query: 949 KQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQ 1008
K KLE NK +V + K + + S++ + K S K T +L +Q
Sbjct: 560 KSKLEHA---NKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 616
Query: 1009 LTESSQTSISLESDLKHITSEADSDPG-----------NPVELCKTQKQSTTTLNKK--- 1054
+ + + + +++++ ++ DS+ +++ K ++ S + K
Sbjct: 617 I---EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673
Query: 1055 --DLPFVE------EIKEGECQVKKVNKMTSKSKKRKTSIDP-SPESHEVMERILD---- 1101
D VE +++E E +VK++ + +K ++ ID + + E++LD
Sbjct: 674 AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 733
Query: 1102 ---SVQGKSTVS------EQADKE-NNLENEKMVKN-KPDFYTKAFRSLSEIHSPNIQD- 1149
S +GKS + E A+K+ +LE EK ++ K T+ + E+ N+Q+
Sbjct: 734 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG-RELKLTNLQEN 792
Query: 1150 -SSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
S V+E L + I+KE FA A V E +NK+ K
Sbjct: 793 LSEVSQVKETL------EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.4 bits (137), Expect = 9e-08
Identities = 140/779 (17%), Positives = 303/779 (38%), Gaps = 99/779 (12%)
Query: 16 IKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRI 75
++R L+ + + +++SL +I + + + + + +L + +E ++
Sbjct: 518 LRRRLESNKPAGDVDMSLSLLQEISS-LQEKLEVTRTDHQREITSLKEHFGAREETHQK- 575
Query: 76 TTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAI-----EMSSLSEF 130
E L EKL+ EN L+ KL + NK+ D+ AL + L TAI M L
Sbjct: 576 --EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
Query: 131 HQSSFLLSASKKKRISKQCKLMRLPFA-RVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIP 189
++ + Q + MRL + + N + E + +++K + I
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
Query: 190 SSGSTTQPL-STQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSL 248
++ + + S D +E L E + L ++E + ++ ++ + +
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE--IKVKELEVLQAKCNEQTKVIDNF 751
Query: 249 MSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCN 308
S+++ + EK + + E L A ++ I E+ N
Sbjct: 752 TSQLKATE------EKLLDLDALRKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKN 801
Query: 309 NEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQ---KTVYDADM 365
E + + E+Q + L L + N ++Q+++ + +LQ + +A
Sbjct: 802 AE-SSKASSITRELQGRELKLTNL------QENLSEVSQVKETLEKELQILKEKFAEASE 854
Query: 366 DLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDI 425
+ + + S TV+ +K+ ++ R+ K RE+ +R+ +
Sbjct: 855 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE---EQLIKA 911
Query: 426 GEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRE 485
EK+EN D+ + + + D N+ QL +MN++L ++ E LQ + +
Sbjct: 912 KEKLEN-----DIAEIMKMSGD-----NSSQLTKMNDEL-RLKERDVEELQLKLTKANEN 960
Query: 486 NVLCNKKEKRITNEQEETYSLSQSSGKFHQ-------------ESKFDKGQNSLTCNKSK 532
K + +T + E++ Q + K H+ E K + N K++
Sbjct: 961 ASFLQKSIEDMTVKAEQS---QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 533 ASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDL 592
R T K + + +L N + + LD ++ A ++N L + +L
Sbjct: 1018 YERATSET-KTKHEEILQNLQKTL-----LDTEDKLKGAR---EENSGL----LQELEEL 1064
Query: 593 KKYVTDIQPSEQNESNINKLRKKVNRKTEIISG--------------MNHMYEDNDKDVV 638
+K + ++ E + + + KTE ++ ++ + E+N K+V
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
Query: 639 HGLKKGNFFFKTQEDKEPISENIEVSKEL---QIPALSTRDNENQCDYRTQNVLGLQK-Q 694
K + E + IE K+ + LS EN + LG + +
Sbjct: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEEN---VKLAEELGRSRDE 1181
Query: 695 ITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEI 753
+T+ +++ S +N +L + R+++ I + + + S++ ++ S LT+KD E+
Sbjct: 1182 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD--EEKASLQKSISITSALLTEKDAEL 1238
Score = 50.8 bits (120), Expect = 8e-06
Identities = 154/800 (19%), Positives = 298/800 (37%), Gaps = 151/800 (18%)
Query: 342 AECMNQIEDNDDFQLQKTVYDADMDLTA-SEVSKI-----VTVS------TGIKKK--SN 387
AE ++E N K D DM L+ E+S + VT + T +K+ +
Sbjct: 516 AELRRRLESN------KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 388 KKTNEHGMKT-FRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAE 446
++T++ +K + + S E + +SK + N + D+ +++ E + + ++ E
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA-IASHQQAME 628
Query: 447 DPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSL 506
+ F+ + E +++KM L Q + EN L N+++ +E +L
Sbjct: 629 ELKVSFSKGLGTETAEFAELKTQIEKMRLDY---QHEIEN-LQNQQDSERAAHAKEMEAL 684
Query: 507 SQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTN 566
K +E +NSL +SK + K E +L+ E D N
Sbjct: 685 RAKLMKVIKEK-----ENSLEAIRSK-------LDKAEDQHLV----------EMEDTLN 722
Query: 567 EFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGM 626
+ A + K+ L + + + ++ +E+ +++ LRK + + +
Sbjct: 723 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 782
Query: 627 NHMYEDNDKDVVH----------------------GLKKGNF---FFKTQEDKEPISENI 661
E +K + H LK N + + KE + + +
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842
Query: 662 EVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYP-----VQQNESKVNKKLRQKV 716
++ KE A + + T N L +++ NM +++N + + K R+K
Sbjct: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902
Query: 717 NRKTEIISEVNHLDND----------KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFET 766
R+ ++I L+ND S + T + L L ++D E + L +E +
Sbjct: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 962
Query: 767 PALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL--NVCQKSEIIPETNQ 824
+ + + + Q KH + + + S + KK N CQ E
Sbjct: 963 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ------ELKA 1016
Query: 825 IYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLI---KDNGNLCDYDTQ 881
YE S T E I +NLQ T T D L ++N L Q
Sbjct: 1017 RYERAT------------SETKTKHEEILQNLQKTL-LDTEDKLKGAREENSGLL----Q 1059
Query: 882 NILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAH----VQESY 937
+ EL+K K+A+ E + + KTE ++ + + N K + ++E+
Sbjct: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1119
Query: 938 TKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNI 997
K+++ ++NKSK+ L V+ +K E K
Sbjct: 1120 LKNVE-ELNKSKELL-----------------------------TVENQKMEEFRKEIET 1149
Query: 998 LTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLP 1057
L +A + + QL+ + ++ L +L E S E Q + K++
Sbjct: 1150 LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ-LLEMKKRESK 1208
Query: 1058 FVEEIKEGECQVKKVNKMTS 1077
F+++ E + ++K +TS
Sbjct: 1209 FIKDADEEKASLQKSISITS 1228
Score = 37.0 bits (84), Expect = 0.12
Identities = 115/535 (21%), Positives = 219/535 (40%), Gaps = 99/535 (18%)
Query: 701 VQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLED 760
V + E+K+++ E + +N L+ +K K L +++ I G+LE
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKR-----KVEDLQFRVEEESITKGDLET 457
Query: 761 PSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIP 820
++ E + + L++ + L + S+I + + + E+
Sbjct: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517
Query: 821 ETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTN-EFQTVDLLIKDNGNLCDYD 879
++ N G D+ SL ++ ++ E L+VT + Q +K++ +
Sbjct: 518 LRRRLESNKPAGDVDMS----LSLL-QEISSLQEKLEVTRTDHQREITSLKEHFGAREET 572
Query: 880 TQNILELKK-YVTDRKSAEQNESKINKLR--NKVN------WKTEI---ISEMNQIYEDN 927
Q E+K Y K +++NES +KL NK N WK+++ I+ Q E+
Sbjct: 573 HQK--EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE- 629
Query: 928 DKDAHVQESYTKDLDFKVNKS---KQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVK 984
++ S++K L + + K ++E + +H +E N+++S
Sbjct: 630 -----LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS------------ 672
Query: 985 KRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEAD-SDPGNPVELCKT 1043
E + AK + + KL + E E+ L+ I S+ D ++ + VE+
Sbjct: 673 ----ERAAHAKE-MEALRAKLMKVIKEK-------ENSLEAIRSKLDKAEDQHLVEM--- 717
Query: 1044 QKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDP-SPESHEVMERILD- 1101
TLNK ++E E +VK++ + +K ++ ID + + E++LD
Sbjct: 718 ----EDTLNK--------LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 765
Query: 1102 ------SVQGKSTVS------EQADKE-NNLENEKMVKN-KPDFYTKAFRSLSEIHSPNI 1147
S +GKS + E A+K+ +LE EK ++ K T+ + E+ N+
Sbjct: 766 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG-RELKLTNL 824
Query: 1148 QD--SSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK 1200
Q+ S V+E L + I+KE FA A V E +NK+ K
Sbjct: 825 QENLSEVSQVKETL------EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 55.1 bits (131), Expect = 4e-07
Identities = 139/740 (18%), Positives = 296/740 (40%), Gaps = 123/740 (16%)
Query: 453 NNEQLAQMNEQLAQVNELKKMTLQTGFE---------QGDRENVLCNKKEKRITNEQEET 503
+ ++++++NE +E +K+TL + Q +++ + N + R E +T
Sbjct: 433 HQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492
Query: 504 YSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHK---LEKDNLLPNQKDKVTIYE 560
L +S+GK QE + K Q + ++ + +T K LE N L + +K+ +
Sbjct: 493 -ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 551
Query: 561 NLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKT 620
L E NL K+ L + + ++ E IN L ++ K
Sbjct: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTM-----------LKELEGKINSLTEE---KD 597
Query: 621 EIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDK-------EPISENIEVSKELQIPALS 673
+ I+ + + +E+ D NF K + ++ + + + I+ + EL+
Sbjct: 598 DFINKLKNSHEEMD----------NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNE 647
Query: 674 -TRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDND 732
T E + QN L+K + M + +++ ++ +++ ++ SE L D
Sbjct: 648 LTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD 707
Query: 733 KSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGN-LYDSEIQNVLGVK-- 789
+ FL+QK+ I+ ++ + + +D+ N L ++E L VK
Sbjct: 708 LEV---------FLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQ 758
Query: 790 -HGHDMQPACQNDSKIGKKPRLNVCQK-SEIIPETNQ-----IYENDNKGVHDLEKDNFF 842
+G + + +K +NV Q E + + N+ ++ D K V +LEK+
Sbjct: 759 LYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEK-VLELEKE--- 814
Query: 843 SLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESK 902
+ LQ + Q +L L DY+ + +L K+ + E +S
Sbjct: 815 ----------IKCLQEESVVQCEEL----KSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
Query: 903 INKLRNKVNWKTEI--------ISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLEC 954
+ +++N N KT + + E++Q ++ ++ + K+ + +QK E
Sbjct: 861 LLEMKN-ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK-EL 918
Query: 955 QD-----IINKHYMEVNSNEK-------ESCDQILDSYKVVKKRKKESSCKAKNILTKAK 1002
+D I+ K + + + K + ++ +++ + K K+E K K + KAK
Sbjct: 919 RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978
Query: 1003 NKLASQLTESSQTSISLES----------DLKHITSEADSDPGNPVELCK------TQKQ 1046
+L S E+ LES ++ + A+S +E K +K+
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 1047 STTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGK 1106
+ +++ Q + +N R ++ + + EV +IL+ + K
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV--QILEVQRAK 1096
Query: 1107 STVSEQADKENNLENEKMVK 1126
+ V ++ + E L+ E+ +K
Sbjct: 1097 AMVDKELEAE-KLQKEQKIK 1115
Score = 47.8 bits (112), Expect = 7e-05
Identities = 103/531 (19%), Positives = 217/531 (40%), Gaps = 85/531 (16%)
Query: 78 EKMLLQKEVEKLNFENTFLR---LKLNNLNKKLIDIEALMNNNLITAIE----MSSLSEF 130
EK+LL+KE+E++ E L+ L++ N N+K L N NL+ +E S SE
Sbjct: 839 EKVLLRKELEEIQSEKEALQSDLLEMKNANEKT----RLENQNLLIQVEEVSQTCSKSEI 894
Query: 131 H---QSSFLLSASKKKRISKQCKL---------MRLPFARVPLTSNDDEDEDKEKMQCDN 178
H + F+ K + +Q +L ++ A+ P ND KE +
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 179 NIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHS 238
N++ K + + + ++ + E+ ++ Q V E + S+ S
Sbjct: 955 NLE-KECKEKEEKINKIKLVAVKAKKELDSSRKETQTV-----KEELESL--------RS 1000
Query: 239 HSDQ--SSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCAT-VL 295
DQ +S L+ + +++ +EK S E+++ +NN T L
Sbjct: 1001 EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKER------ANNFEHRIEDLTRQL 1054
Query: 296 DKQHISSPELNCNNE---INGHTNETNT--------EMQRNKQ------DLPGLSSESAR 338
+ +N +NE T ++N E+QR K + L E
Sbjct: 1055 RNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI 1114
Query: 339 EPNAECMNQIED------NDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNE 392
+ +A +N++E+ + QLQKT+ + ++ ++ + ++ + ++ K+ N+
Sbjct: 1115 KEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQ 1174
Query: 393 HGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIF 452
K++D E K ++ K++ + ++ E++ + +
Sbjct: 1175 KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQL-------LVK 1227
Query: 453 NNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGK 512
++LA ++Q + + + +L+ E ++ + + IT+E+ + + ++S +
Sbjct: 1228 TKKELAD-SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAE 1286
Query: 513 FHQE--SKFDKGQNSL--TCNKSKASRQT----FVIHKLEKDNLLPNQKDK 555
HQ S + + +L C +KA + T F +K+ N+L QK+K
Sbjct: 1287 QHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337
Score = 45.8 bits (107), Expect = 3e-04
Identities = 143/830 (17%), Positives = 303/830 (36%), Gaps = 122/830 (14%)
Query: 377 TVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERS 436
T+ ++ K N T E K+K+S E K + + +++G+K+E + +
Sbjct: 580 TMLKELEGKINSLTEEKD-DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYN 638
Query: 437 DVLDGK--------------------------------------RGAEDPGFIFNNEQLA 458
L+ K AE N +L+
Sbjct: 639 SELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLS 698
Query: 459 QMNEQLAQ-----------------VNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQE 501
+QL++ + +L+K LQ E+ D N L ++ + +
Sbjct: 699 SEKKQLSRDLEVFLSQKEDVILKEHITQLEK-KLQLMVEEQDNLNKLLENEQVQKLFVKT 757
Query: 502 ETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYEN 561
+ Y + G E +K N +A ++ EK NL + +KV E
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKD----VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEK 813
Query: 562 LDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKT- 620
+ + + L DY +L L+K + +IQ ++ + K N KT
Sbjct: 814 EIKCLQEESVVQCEELKSLLRDYEQEKVL-LRKELEEIQSEKEALQSDLLEMKNANEKTR 872
Query: 621 ----EIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEV---SKELQIPALS 673
++ + + + K +H +K F K E+ +P+ E E+ EL + S
Sbjct: 873 LENQNLLIQVEEVSQTCSKSEIHN-EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDS 931
Query: 674 TRDNENQCDYRTQNVLGLQKQITNM-YPVQQNESKVNKKLRQKVNRKTEIISEVNHLDND 732
+ + + +V L+++I N+ ++ E K+NK V K E+ S
Sbjct: 932 LAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
Query: 733 KSIEYTVKSHSLFLTQKDKEIIPG-----NLEDPSEFETPALST-KDSGNLYDSEIQNVL 786
K +++S L+ +++I G NL E ++ L K+ N ++ I+++
Sbjct: 992 KEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLT 1051
Query: 787 GVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTP 846
+Q N R+ Q + + E + K + D E + +
Sbjct: 1052 RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE---AEKL 1108
Query: 847 KDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKL 906
+ ++ I E+ NE + + + ++ Q + +KK + +L
Sbjct: 1109 QKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERL 1168
Query: 907 RNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNK--------SKQKLECQDII 958
++N K ++ N ED +++ +Q+ + L ++ ++ + + ++
Sbjct: 1169 MKELNQK---LTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLL 1225
Query: 959 NKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNI-------LTKAKNKLASQL-T 1010
K E+ +++ D ++ + K + E+S + + +T K+K+ L T
Sbjct: 1226 VKTKKELADSKQAETDHLI--LQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT 1283
Query: 1011 ESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVK 1070
+ Q +L + + +T+ E C+ K T+ E + + +V
Sbjct: 1284 SAEQHQRTLSAYQQRVTALQ--------EECRAAKAEQATV-------TSEFESYKVRVH 1328
Query: 1071 KVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLE 1120
V K + + + + E +E ++D ++ K D +NNL+
Sbjct: 1329 NVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIK-----LQDSQNNLQ 1373
Score = 42.0 bits (97), Expect = 0.004
Identities = 98/501 (19%), Positives = 203/501 (40%), Gaps = 78/501 (15%)
Query: 659 ENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMY--------PVQQNESKVNK 710
ENI++ +E++ D + + Q+ + K+I N+ ++++ + K
Sbjct: 98 ENIKMKQEVEDSVTKMGDAHKELE---QSHINYVKEIENLKNELMAVRSKYSEDKANLQK 154
Query: 711 KLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALS 770
+L + +N + E+ ++ +N E VK L ++ ++I PG E + +
Sbjct: 155 QLEEAMNTQLELSEQLKFQNNS---EDNVKK----LQEEIEKIRPGFEEQILYLQKQLDA 207
Query: 771 TKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDN 830
T D +++QN++ H + N+ E + + I++ +
Sbjct: 208 TTDEKKETVTQLQNIIEANSQHYQK---------------NINSLQEELLQLKAIHQEE- 251
Query: 831 KGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYV 890
K+ + KE +E + NE + + L+K C+ +NI KKY
Sbjct: 252 ------VKELMCQIEASAKEHEAE-INKLNELK--ENLVKQ----CEASEKNIQ--KKYE 296
Query: 891 TDRKSAEQNESKINK-------LRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDF 943
+ ++ + S N+ L + + ++++E + ED K+ Q S KD
Sbjct: 297 CELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 356
Query: 944 KVNKSKQKLE--CQDIINKHYMEVNSNEKESCDQILDSYK---VVKKRKKESSCKAKNI- 997
+N K KLE Q I ++ + E E + + +L + V++K K E + K
Sbjct: 357 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFC 416
Query: 998 -LTKAKNKLASQLTESSQTSISLESDLKHITSEADS-----DPGNPVELCKT--QKQSTT 1049
+ N+ L E Q IS ++ SE + + E C+ Q++
Sbjct: 417 YTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA 476
Query: 1050 TLNKKDLPFVEEIKEGEC--QVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKS 1107
LN + L + EI + E K+++ K+++ S + HE+ +++ + K
Sbjct: 477 ILNYESLREIMEILQTELGESAGKISQEFESMKQQQAS-----DVHELQQKLRTAFTEKD 531
Query: 1108 TVSEQADKENNLENEKMVKNK 1128
+ E ++ ENEK++ +
Sbjct: 532 ALLETVNRLQG-ENEKLLSQQ 551
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 54.3 bits (129), Expect = 7e-07
Identities = 97/498 (19%), Positives = 214/498 (42%), Gaps = 62/498 (12%)
Query: 649 KTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKV 708
K + KE +S E +L T +NEN+ ++ L++ + N + NE +
Sbjct: 860 KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQN----KDNEFAL 915
Query: 709 NKKLRQKV----NRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEF 764
K ++ V N K + + E+ ++ + ++ E S + +D + + ++ +
Sbjct: 916 VKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQL 975
Query: 765 ETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQ 824
L + + +L E+++ L V+H Q K+ R+++ E+ E Q
Sbjct: 976 LRAELQSLEQSHL--KELEDTLQVRH-------IQEFEKVMTDHRVSL---EELKKENQQ 1023
Query: 825 IYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQT-----VDLLIKDNGNLCDYD 879
I ++ +++ + + K+K+ L+V++ T V+L +K+ +
Sbjct: 1024 I-------INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEA------E 1070
Query: 880 TQNILELKKYVTDRKSAEQNESKINKLRNKV-NWKTEIISEMNQIYEDNDKDAHVQESYT 938
T I K + + A+Q E+ + L + N +TEI S++NQ +DN+++ V +
Sbjct: 1071 TDEI----KILLEESRAQQKETLKSLLEQETENLRTEI-SKLNQKIQDNNENYQVGLAEL 1125
Query: 939 KDLDFKVNKSKQKLEC-QDIINKHYMEVN--SNEKESCDQILDSYKVVKKRKKESSCKAK 995
+ L + +K +C ++I++H E N E + + ++K KE + +
Sbjct: 1126 RTL-----MTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQ 1180
Query: 996 -------NILTKAKNKLASQLTESSQTSI-SLESDLKHITSEADSDPGNPVELCKTQKQS 1047
+ L + K++ +Q E + I +LE D + + S + D ++ +K
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE 1240
Query: 1048 TTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQ-GK 1106
K+ E+ E E ++KV + ++ K +S ++ + + +Q K
Sbjct: 1241 AIQTALKEFKLEREVVEKEL-LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
Query: 1107 STVSEQADKENNLENEKM 1124
+ EQ +++ +NE+M
Sbjct: 1300 AKFLEQLEEQEKRKNEEM 1317
Score = 41.2 bits (95), Expect = 0.006
Identities = 79/395 (20%), Positives = 167/395 (42%), Gaps = 40/395 (10%)
Query: 745 FLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKI 804
F++ ++ +I NL P+ P +LY S I N + + D + D
Sbjct: 732 FMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVI-NAIDSRRMQDTNVCGKED--F 788
Query: 805 GKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKD--NFFSLTPKDKETISENLQVTN-E 861
G LNV + + ++ + + +++D +F + K++ S +L+ T E
Sbjct: 789 GDHTSLNVQ-----LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVE 843
Query: 862 FQTVDLLIKDNGNLC--DYDTQNILELKKYVTDR-----KSAEQNESKINKLRNKVNWKT 914
+ + +K + + + + +L LK + K E+NE+KI KL+ ++
Sbjct: 844 IRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
Query: 915 EIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCD 974
E++ +DN+ A V+ + + K ++ LE ++I++ E+ K+S +
Sbjct: 904 EVLQN-----KDNE-FALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEI-KELKQSRE 956
Query: 975 QILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDP 1034
+L+ +KK E+ K + + + ++ S L E T ++HI
Sbjct: 957 IVLED---LKKLHVENDEKLQLLRAELQSLEQSHLKELEDT-----LQVRHIQEFEKVMT 1008
Query: 1035 GNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSID-----PS 1089
+ V L + +K++ +N+ E I+E E Q++++ S + ++
Sbjct: 1009 DHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKE 1068
Query: 1090 PESHEVMERILDS-VQGKSTVSEQADKE-NNLENE 1122
E+ E+ + +S Q K T+ ++E NL E
Sbjct: 1069 AETDEIKILLEESRAQQKETLKSLLEQETENLRTE 1103
Score = 41.2 bits (95), Expect = 0.006
Identities = 107/538 (19%), Positives = 215/538 (39%), Gaps = 64/538 (11%)
Query: 599 IQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPIS 658
I+ +E+NE+ I KL+ ++ E++ +DN+ +V K+ + ++D++ +
Sbjct: 882 IKETEENENKIKKLKGELVCLEEVLQN-----KDNEFALVKHEKEAVICLQNEKDQKLLE 936
Query: 659 -ENIEVSKELQIPALSTRDN---ENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQ 714
ENI S+ +I L E+ +N LQ + ++Q+ K + Q
Sbjct: 937 MENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQ 996
Query: 715 --------KVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFET 766
KV + E +N + I +SH+ + +K+K++ L+ +T
Sbjct: 997 VRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT 1056
Query: 767 PA-----LSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPE 821
L+ K++ EI+ +L + + + R + + ++ I +
Sbjct: 1057 RCKLEVELALKEAET---DEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQD 1113
Query: 822 TNQIYE---NDNKGVHDLEKDNFFSLTPKDKETISENLQVTN----EFQTVDLLIKDNGN 874
N+ Y+ + + + +EKD S E IS + + +N E V L
Sbjct: 1114 NNENYQVGLAELRTLMTIEKDQCIS------ELISRHEEESNILKAELNKVTSLHNQAFE 1167
Query: 875 LCDYDTQNILELKKYVTDRKSA--EQNESKINKLRNKVNWKTEIISEMNQ---IYEDNDK 929
+ + I+EL+ + SA Q + KI + K + + + Q ++ D+
Sbjct: 1168 IEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDR 1227
Query: 930 DAHVQE-SYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKK 988
+ +Q+ + KD + + KLE ++++ K +E K +QI S + R
Sbjct: 1228 EQLIQKLNCEKDEAIQTALKEFKLE-REVVEKELLE---KVKHLENQIAKSPAIDSTRGD 1283
Query: 989 ESSCKA--KNILTKAKNKLASQLTESS----------QTSISLE--SDLKHITSEADSDP 1034
SS A + L + K K QL E +TS+ E ++ + +
Sbjct: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRK 1343
Query: 1035 GNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSK--SKKRKTSIDPSP 1090
N + + +ST ++D +E + E ++ + K + SK R +S PSP
Sbjct: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
Score = 38.1 bits (87), Expect = 0.054
Identities = 99/534 (18%), Positives = 209/534 (39%), Gaps = 66/534 (12%)
Query: 52 ISLKHNNRALAQALSREKENS----RRITTEKMLLQKEVEKLNFENTFLRLK-------- 99
+SLK+ L +E E + +++ E + L++ ++ N +N F +K
Sbjct: 868 LSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQ--NKDNEFALVKHEKEAVIC 925
Query: 100 -LNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQS-SFLLSASKKKRISKQCKLMRLPFA 157
N ++KL+++E +M++ + + E QS +L KK + KL L
Sbjct: 926 LQNEKDQKLLEMENIMHS------QNCEIKELKQSREIVLEDLKKLHVENDEKLQLL--- 976
Query: 158 RVPLTSNDD------ED-------EDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNS 204
R L S + ED ++ EK+ D+ + +L ++ + ++
Sbjct: 977 RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRV---SLEELKKENQQIINQIQESHA 1033
Query: 205 EVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQ--SIGRRW 262
E++ KE L S+ + + + ++ L+ E R Q ++
Sbjct: 1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLL 1093
Query: 263 EKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEM 322
E+ + + TE K + NN + A + I + C +E+ E + +
Sbjct: 1094 EQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ--CISELISRHEEESNIL 1151
Query: 323 QRNKQDLPGLSSESAR-EPNA-ECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVST 380
+ + L +++ E N E + +++ D +L D +T E K +
Sbjct: 1152 KAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE-EKYEAIIQ 1210
Query: 381 GIKKKSNKKTNEHGMKTFRKVKDSSSEKKR--ERSKRQFKNSSDV---DIGEKI---ENR 432
++K K + + ++ + EK + + ++FK +V ++ EK+ EN+
Sbjct: 1211 NLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
Query: 433 TERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKK 492
+S +D RG ++ +A++ E+L E K L+ EQ R+N
Sbjct: 1271 IAKSPAIDSTRGD-------SSSLVAELQEKL---QEEKAKFLEQLEEQEKRKNEEMQNV 1320
Query: 493 EKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKD 546
+ EQ+ ++ + K +E+ + + L + R +I L +D
Sbjct: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED 1374
Score = 34.3 bits (77), Expect = 0.77
Identities = 75/413 (18%), Positives = 160/413 (38%), Gaps = 68/413 (16%)
Query: 294 VLDKQHISSPELNCNNE-INGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDND 352
V+ +S EL N+ I E++ E+ + K+ + E ++ D
Sbjct: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE-----------KQLQELKLKVSDLS 1054
Query: 353 DFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRER 412
D + + V A + E+ ++ S +K++ K E + R ++K ++
Sbjct: 1055 DTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDN 1114
Query: 413 SKRQ----------FKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNE 462
++ D I E I E S++L + N+ + N+
Sbjct: 1115 NENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL----------NKVTSLHNQ 1164
Query: 463 QLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKG 522
LK+ ++ + + L +K+++IT ++E+ ++ Q+ K Q+ +
Sbjct: 1165 AFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQE 1224
Query: 523 QN------SLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTK 576
Q+ L C K +A + KLE++ + +KV EN + + +
Sbjct: 1225 QDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSP--AIDSTRG 1282
Query: 577 DNGNLCDYGTHNILDLK-KYVTDIQPSE----------------QNESNINK-LRKKVNR 618
D+ +L + + K K++ ++ E + ++N N L ++ R
Sbjct: 1283 DSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMR 1342
Query: 619 KTEIISGMNH------MYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSK 665
K II+ ++ ++ DKD++ L + + E+K+ + E EVSK
Sbjct: 1343 KENIINDLSDKLKSTMQQQERDKDLIESLSEDR--ARLLEEKKKLEE--EVSK 1391
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 54.3 bits (129), Expect = 7e-07
Identities = 97/498 (19%), Positives = 214/498 (42%), Gaps = 62/498 (12%)
Query: 649 KTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKV 708
K + KE +S E +L T +NEN+ ++ L++ + N + NE +
Sbjct: 860 KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQN----KDNEFAL 915
Query: 709 NKKLRQKV----NRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEF 764
K ++ V N K + + E+ ++ + ++ E S + +D + + ++ +
Sbjct: 916 VKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQL 975
Query: 765 ETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQ 824
L + + +L E+++ L V+H Q K+ R+++ E+ E Q
Sbjct: 976 LRAELQSLEQSHL--KELEDTLQVRH-------IQEFEKVMTDHRVSL---EELKKENQQ 1023
Query: 825 IYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQT-----VDLLIKDNGNLCDYD 879
I ++ +++ + + K+K+ L+V++ T V+L +K+ +
Sbjct: 1024 I-------INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEA------E 1070
Query: 880 TQNILELKKYVTDRKSAEQNESKINKLRNKV-NWKTEIISEMNQIYEDNDKDAHVQESYT 938
T I K + + A+Q E+ + L + N +TEI S++NQ +DN+++ V +
Sbjct: 1071 TDEI----KILLEESRAQQKETLKSLLEQETENLRTEI-SKLNQKIQDNNENYQVGLAEL 1125
Query: 939 KDLDFKVNKSKQKLEC-QDIINKHYMEVN--SNEKESCDQILDSYKVVKKRKKESSCKAK 995
+ L + +K +C ++I++H E N E + + ++K KE + +
Sbjct: 1126 RTL-----MTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQ 1180
Query: 996 -------NILTKAKNKLASQLTESSQTSI-SLESDLKHITSEADSDPGNPVELCKTQKQS 1047
+ L + K++ +Q E + I +LE D + + S + D ++ +K
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE 1240
Query: 1048 TTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQ-GK 1106
K+ E+ E E ++KV + ++ K +S ++ + + +Q K
Sbjct: 1241 AIQTALKEFKLEREVVEKEL-LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
Query: 1107 STVSEQADKENNLENEKM 1124
+ EQ +++ +NE+M
Sbjct: 1300 AKFLEQLEEQEKRKNEEM 1317
Score = 41.2 bits (95), Expect = 0.006
Identities = 79/395 (20%), Positives = 167/395 (42%), Gaps = 40/395 (10%)
Query: 745 FLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKI 804
F++ ++ +I NL P+ P +LY S I N + + D + D
Sbjct: 732 FMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVI-NAIDSRRMQDTNVCGKED--F 788
Query: 805 GKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKD--NFFSLTPKDKETISENLQVTN-E 861
G LNV + + ++ + + +++D +F + K++ S +L+ T E
Sbjct: 789 GDHTSLNVQ-----LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVE 843
Query: 862 FQTVDLLIKDNGNLC--DYDTQNILELKKYVTDR-----KSAEQNESKINKLRNKVNWKT 914
+ + +K + + + + +L LK + K E+NE+KI KL+ ++
Sbjct: 844 IRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
Query: 915 EIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCD 974
E++ +DN+ A V+ + + K ++ LE ++I++ E+ K+S +
Sbjct: 904 EVLQN-----KDNE-FALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEI-KELKQSRE 956
Query: 975 QILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDP 1034
+L+ +KK E+ K + + + ++ S L E T ++HI
Sbjct: 957 IVLED---LKKLHVENDEKLQLLRAELQSLEQSHLKELEDT-----LQVRHIQEFEKVMT 1008
Query: 1035 GNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSID-----PS 1089
+ V L + +K++ +N+ E I+E E Q++++ S + ++
Sbjct: 1009 DHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKE 1068
Query: 1090 PESHEVMERILDS-VQGKSTVSEQADKE-NNLENE 1122
E+ E+ + +S Q K T+ ++E NL E
Sbjct: 1069 AETDEIKILLEESRAQQKETLKSLLEQETENLRTE 1103
Score = 41.2 bits (95), Expect = 0.006
Identities = 107/538 (19%), Positives = 215/538 (39%), Gaps = 64/538 (11%)
Query: 599 IQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPIS 658
I+ +E+NE+ I KL+ ++ E++ +DN+ +V K+ + ++D++ +
Sbjct: 882 IKETEENENKIKKLKGELVCLEEVLQN-----KDNEFALVKHEKEAVICLQNEKDQKLLE 936
Query: 659 -ENIEVSKELQIPALSTRDN---ENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQ 714
ENI S+ +I L E+ +N LQ + ++Q+ K + Q
Sbjct: 937 MENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQ 996
Query: 715 --------KVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFET 766
KV + E +N + I +SH+ + +K+K++ L+ +T
Sbjct: 997 VRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT 1056
Query: 767 PA-----LSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPE 821
L+ K++ EI+ +L + + + R + + ++ I +
Sbjct: 1057 RCKLEVELALKEAET---DEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQD 1113
Query: 822 TNQIYE---NDNKGVHDLEKDNFFSLTPKDKETISENLQVTN----EFQTVDLLIKDNGN 874
N+ Y+ + + + +EKD S E IS + + +N E V L
Sbjct: 1114 NNENYQVGLAELRTLMTIEKDQCIS------ELISRHEEESNILKAELNKVTSLHNQAFE 1167
Query: 875 LCDYDTQNILELKKYVTDRKSA--EQNESKINKLRNKVNWKTEIISEMNQ---IYEDNDK 929
+ + I+EL+ + SA Q + KI + K + + + Q ++ D+
Sbjct: 1168 IEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDR 1227
Query: 930 DAHVQE-SYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKK 988
+ +Q+ + KD + + KLE ++++ K +E K +QI S + R
Sbjct: 1228 EQLIQKLNCEKDEAIQTALKEFKLE-REVVEKELLE---KVKHLENQIAKSPAIDSTRGD 1283
Query: 989 ESSCKA--KNILTKAKNKLASQLTESS----------QTSISLE--SDLKHITSEADSDP 1034
SS A + L + K K QL E +TS+ E ++ + +
Sbjct: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRK 1343
Query: 1035 GNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSK--SKKRKTSIDPSP 1090
N + + +ST ++D +E + E ++ + K + SK R +S PSP
Sbjct: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
Score = 38.1 bits (87), Expect = 0.054
Identities = 99/534 (18%), Positives = 209/534 (39%), Gaps = 66/534 (12%)
Query: 52 ISLKHNNRALAQALSREKENS----RRITTEKMLLQKEVEKLNFENTFLRLK-------- 99
+SLK+ L +E E + +++ E + L++ ++ N +N F +K
Sbjct: 868 LSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQ--NKDNEFALVKHEKEAVIC 925
Query: 100 -LNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQS-SFLLSASKKKRISKQCKLMRLPFA 157
N ++KL+++E +M++ + + E QS +L KK + KL L
Sbjct: 926 LQNEKDQKLLEMENIMHS------QNCEIKELKQSREIVLEDLKKLHVENDEKLQLL--- 976
Query: 158 RVPLTSNDD------ED-------EDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNS 204
R L S + ED ++ EK+ D+ + +L ++ + ++
Sbjct: 977 RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRV---SLEELKKENQQIINQIQESHA 1033
Query: 205 EVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQ--SIGRRW 262
E++ KE L S+ + + + ++ L+ E R Q ++
Sbjct: 1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLL 1093
Query: 263 EKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEM 322
E+ + + TE K + NN + A + I + C +E+ E + +
Sbjct: 1094 EQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ--CISELISRHEEESNIL 1151
Query: 323 QRNKQDLPGLSSESAR-EPNA-ECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVST 380
+ + L +++ E N E + +++ D +L D +T E K +
Sbjct: 1152 KAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE-EKYEAIIQ 1210
Query: 381 GIKKKSNKKTNEHGMKTFRKVKDSSSEKKR--ERSKRQFKNSSDV---DIGEKI---ENR 432
++K K + + ++ + EK + + ++FK +V ++ EK+ EN+
Sbjct: 1211 NLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
Query: 433 TERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKK 492
+S +D RG ++ +A++ E+L E K L+ EQ R+N
Sbjct: 1271 IAKSPAIDSTRGD-------SSSLVAELQEKL---QEEKAKFLEQLEEQEKRKNEEMQNV 1320
Query: 493 EKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKD 546
+ EQ+ ++ + K +E+ + + L + R +I L +D
Sbjct: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED 1374
Score = 34.3 bits (77), Expect = 0.77
Identities = 75/413 (18%), Positives = 160/413 (38%), Gaps = 68/413 (16%)
Query: 294 VLDKQHISSPELNCNNE-INGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDND 352
V+ +S EL N+ I E++ E+ + K+ + E ++ D
Sbjct: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE-----------KQLQELKLKVSDLS 1054
Query: 353 DFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRER 412
D + + V A + E+ ++ S +K++ K E + R ++K ++
Sbjct: 1055 DTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDN 1114
Query: 413 SKRQ----------FKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNE 462
++ D I E I E S++L + N+ + N+
Sbjct: 1115 NENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL----------NKVTSLHNQ 1164
Query: 463 QLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKG 522
LK+ ++ + + L +K+++IT ++E+ ++ Q+ K Q+ +
Sbjct: 1165 AFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQE 1224
Query: 523 QN------SLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTK 576
Q+ L C K +A + KLE++ + +KV EN + + +
Sbjct: 1225 QDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSP--AIDSTRG 1282
Query: 577 DNGNLCDYGTHNILDLK-KYVTDIQPSE----------------QNESNINK-LRKKVNR 618
D+ +L + + K K++ ++ E + ++N N L ++ R
Sbjct: 1283 DSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMR 1342
Query: 619 KTEIISGMNH------MYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSK 665
K II+ ++ ++ DKD++ L + + E+K+ + E EVSK
Sbjct: 1343 KENIINDLSDKLKSTMQQQERDKDLIESLSEDR--ARLLEEKKKLEE--EVSK 1391
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 54.3 bits (129), Expect = 7e-07
Identities = 162/854 (18%), Positives = 325/854 (38%), Gaps = 135/854 (15%)
Query: 308 NNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDN--DDFQLQKTVYDADM 365
N + G+ ++ E++R K+ L L+S + ++ + N + FQ +
Sbjct: 370 NEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSE 429
Query: 366 DLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDI 425
S + K+ + KK + + FR+ + EK + S+ F +
Sbjct: 430 QEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRL 489
Query: 426 GEKIEN--RTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGD 483
++ N +T R + R A+ + N L + N +L + +K+ ++ D
Sbjct: 490 LSELRNEIQTLREQIEHHPRVAK---YAMENHSLREENRRLRLLEPVKRA------QEMD 540
Query: 484 RENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSK-----ASRQTF 538
+ + K EK + S+ SG K DK Q + K A+ +
Sbjct: 541 AQTIA--KLEK----------AFSEISGM----EKSDKNQQGFSPKAQKEPCLFANTEKL 584
Query: 539 VIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT-ANLSTKDNGNLCDYGTHNILDLKKYVT 597
L+ L N K + ++ L + + L + NL N+L+ K
Sbjct: 585 KAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANL---NLENLLEATKAC- 640
Query: 598 DIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPI 657
Q S +NK+ + +II+ Y+ + + V + F I
Sbjct: 641 ----KRQEVSQLNKIHAET---LKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSI 693
Query: 658 SENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVN 717
+N ++ E P + NE + ++ + +Q+Q++ + E N KL+Q V+
Sbjct: 694 LDN-DILNEPVPPEM----NEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVD 748
Query: 718 RKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNL 777
+ +++ L + + I++T + L L + E T+ +
Sbjct: 749 KLEHHSTQMQELFSSERIDWTKQQEEL-------------LSQLNVLEKQLQETQTKNDF 795
Query: 778 YDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLE 837
SE+ ++ V H D + S + E + N K + L
Sbjct: 796 LKSEVHDLRVVLHSADK-------------------ELSSVKLEYSSFKTNQEKEFNKLS 836
Query: 838 KDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCD-YDTQNILELKKYVTDRKSA 896
+ + D NL++ NE L++ L D YD N+ E+ K+ D+ S
Sbjct: 837 ERHMHVQLQLD------NLRLENE-----KLLESKACLQDSYD--NLQEIMKFEIDQLSR 883
Query: 897 E-QNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQ 955
QN K N+ K+++ + M + + +++ + + +D K N SK+ L+
Sbjct: 884 NLQNFKKENE-----TLKSDLNNLMELLEAEKERNNKLSLQFEED---KENSSKEILKVL 935
Query: 956 DIINKHYMEVNSNEKESCDQ-----------ILDSYKVVK--KRKKESSCKAKNILTKAK 1002
+ + + E C+Q +L + KV+ ++ ++S K L
Sbjct: 936 EAVRQE----KQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQI 991
Query: 1003 NKLASQLTESSQTSISLESDLKHITSEADSDPGNPVE-LCKTQKQSTTTLNKKD---LPF 1058
+L + + E ++T +L+ +LK I + +S + E +KQ L+ K+ L
Sbjct: 992 QELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRI 1051
Query: 1059 VEEIKEGE--CQ-----VKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGK-STVS 1110
+ E E + C+ +++N +T SKK + + E E ++ +Q K +
Sbjct: 1052 LSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKK 1111
Query: 1111 EQADKENNLENEKM 1124
E+ +++ N N KM
Sbjct: 1112 EEVEQKKNEYNFKM 1125
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 53.9 bits (128), Expect = 9e-07
Identities = 72/331 (21%), Positives = 142/331 (42%), Gaps = 32/331 (9%)
Query: 896 AEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQ 955
+E ++ +L N + KT+ SE+ E +D + + L+F+V + +Q L +
Sbjct: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163
Query: 956 DIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQT 1015
D KH+ V + + S + L + + RK++ + L + + +L ++ E Q
Sbjct: 2164 D--RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221
Query: 1016 SISLESDLKHITSEAD---------SDPGNPVELCKTQKQSTTTLNKKDL--PFVEEIKE 1064
+ LE K T+ D + L + + +T ++ L F + I+E
Sbjct: 2222 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQE 2281
Query: 1065 GECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILD-SVQGKSTVSEQADKENNLENEK 1123
E ++ ++N+ +K +++ + E E I D Q + +S+Q + N E E
Sbjct: 2282 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE- 2340
Query: 1124 MVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPA 1183
++ + K + L+ I Q +S ++ S+ +V+I E ALE
Sbjct: 2341 -IEQLNEVIEKLQQELANIG----QKTSMNAHSLSEEADSLKHQLDVVIAEKLALE---- 2391
Query: 1184 FQVSDDEHEKMNKMK-------FKVNRRTQK 1207
Q + +E+M MK FK+N+ TQ+
Sbjct: 2392 -QQVETANEEMTFMKNVLKETNFKMNQLTQE 2421
Score = 52.8 bits (125), Expect = 2e-06
Identities = 189/1066 (17%), Positives = 421/1066 (39%), Gaps = 165/1066 (15%)
Query: 27 KTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA--LAQALSREKENSRRITTEKMLL-- 82
++ KL + ++ L NS+ H++ A L QA + + +++ + LL
Sbjct: 234 QSQKLQIQFQQLQASETLRNST-------HSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Query: 83 -QKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASK 141
QK+ E + +FL+ K+ K+ ++E +E S+ E + ++
Sbjct: 287 YQKKKEDFTMQISFLQEKI-----KVYEMEQDKK------VENSNKEEIQEKETIIEELN 335
Query: 142 KKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQ 201
K I ++ K + L + LT+ D + ++ N + K + ++ + S++
Sbjct: 336 TKIIEEEKKTLEL---KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 202 DNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRR 261
+ +++ E Q DS+ + IV +E+ +Q + EM Q + +
Sbjct: 393 EIKQLMGTVEELQK-RNHKDSQFETDIVQRMEQETQRKLEQLRAE--LDEMYGQQIVQMK 449
Query: 262 WE--KPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETN 319
E + + + E K R N L + + D+ + + +N E+N +TN
Sbjct: 450 QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN---ELNIKLQDTN 506
Query: 320 TEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVS 379
++ ++ K++L GL E + LQ+ + D +L+ S +I
Sbjct: 507 SQKEKLKEEL-GLILE----------------EKCALQRQLEDLVEELSFSR-EQIQRAR 548
Query: 380 TGIKKKSNKKTNEH-GMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDV 438
I ++ +K H + T +K R + + K+ ++V N + ++
Sbjct: 549 QTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV------TNYKIKLEM 602
Query: 439 LDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
L+ ++ N L +M E +Q EL+++ Q F E L KE
Sbjct: 603 LEKEK----------NAVLDRMAE--SQEAELERLRTQLLF---SHEEELSKLKEDLEIE 647
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTI 558
+ L + G H + + D QN ++ Q + EKDNL+ Q +
Sbjct: 648 HRINIEKLKDNLG-IHYKQQIDGLQNEMS--------QKIETMQFEKDNLITKQNQLILE 698
Query: 559 YENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNR 618
L + + +++K + T I +L+K + ++ E+ + + + +++
Sbjct: 699 ISKL---KDLQQSLVNSKS-----EEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 619 KTEIISGMNHMYEDNDKDVVHGLKKGNFFF----KTQED----KEPISENIEV------- 663
KTE++ E++ ++ L+ N KT ED P+S+ +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 664 --------SKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVN-KKLRQ 714
KE++I D + QC + + +KQ N + + +VN ++L++
Sbjct: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI---EKQ-RNTFSFAEKNFEVNYQELQE 866
Query: 715 KVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPS----EFETPALS 770
+ ++ ++ N + +EY K +L + I P ++ S E +T
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
Query: 771 TKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQK-SEIIPETNQIYEND 829
T + G + + + ++ ++ K+ +L + Q+ S++ + Q
Sbjct: 927 TLEMGEVVEKDTTELM-------------EKLEVTKREKLELSQRLSDLSEQLKQ----- 968
Query: 830 NKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK----DNGNLCDYDTQNILE 885
+ L + K E QV+ + ++++I +N CD ++L+
Sbjct: 969 -------KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 886 LKKYVTDRKSAEQNESKINKL---RNKVNWKTEIISEMNQIYEDNDKDAHVQE---SYTK 939
+T R AE + SK+NK +K+ + ++ E + E++ ++ + + S TK
Sbjct: 1022 GVVTMTSR-GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 940 DLDFKVNKSKQKLECQDIIN-----KHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKA 994
+ + + + + Q +N ++ + + + C ++ S V + R+ + K
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 995 KNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVEL 1040
K + + + + +Q + + + +L+ + ++ D G P+ L
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Score = 43.5 bits (101), Expect = 0.001
Identities = 87/476 (18%), Positives = 180/476 (37%), Gaps = 77/476 (16%)
Query: 821 ETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDT 880
E ++ EN NK ++ L K E + L++ ++ T D L+ +
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 881 QNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKD 940
Q I +K +T+ K E+ S+ K +++ + ++ + N KD+ + +
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIK---------QLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 941 LDFKVNKSKQKLEC--------------QDIINKHYM---EVNSNEKESCDQILDSYKVV 983
++ + + ++L Q++I +H E+ + K + L SY +
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
Query: 984 KKRKKESSCKAKNI-----------LTKAKNKLASQLTESSQTSISLESDLKHITSEADS 1032
E K N+ K KL +L + +L+ L+ + E
Sbjct: 482 --TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 1033 DPGNPVELCKTQKQSTTTLNK--KDLPFVEEIK-----------------EGECQVKKVN 1073
+T + + LN+ K L VE++K E E K+
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI- 598
Query: 1074 KMTSKSKKRKTSIDPSPESHEV-MERILDSV-----QGKSTVSEQADKENNLENEKMVKN 1127
K+ K++ +D ES E +ER+ + + S + E + E+ + EK+ N
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 658
Query: 1128 KPDFYTKAFRSLSEIHSPNIQDSSFDS----VREGLVPLSVSSGKNVIIKENFALECSPA 1183
Y + L S I+ F+ ++ + L +S K+ ++++ S
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKD--LQQSLVNSKSEE 716
Query: 1184 FQVSDDEHEKMNKMKFKVNRRTQK-SGIGDRPLQDLS-NTSFVSNNTAESENKSED 1237
+ +E +K + ++ R+ +K G ++ +Q+L T + E EN ++
Sbjct: 717 MTLQINELQK----EIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Score = 38.1 bits (87), Expect = 0.054
Identities = 188/1108 (16%), Positives = 436/1108 (39%), Gaps = 150/1108 (13%)
Query: 21 KDKRISKTTKLNVSLASKIKT--KILNNSSIFKISLKHNNRALAQALSREKENSRRITTE 78
KD I+K +L + + SK+K + L NS +++L+ N L +E E R+ E
Sbjct: 685 KDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE------LQKEIEILRQEEKE 737
Query: 79 KMLLQKEVEKLNFENTFLRLKL----NNLNKKLIDIEA---LMNNNLITAIEM----SSL 127
K L++EV++L + L ++ N+L +K +EA ++ + T +M + +
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV 797
Query: 128 SEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPD 187
S+ + FL S K + S K + + ++ED ++ +Q + I+ +
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEK-------EIEILIEENEDLKQQCIQLNEEIEKQR--- 847
Query: 188 IPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIV----DVPPRESHSHSDQS 243
E N V + E + ++ D+ ++ +
Sbjct: 848 -----------------NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
Query: 244 SKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSP 303
SK ++E + Q I K S E K + + +++K ++
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 304 ELNCNNEINGHTNETNTEMQRNKQDLPGLSSE-----SAREPNAECMNQIEDNDDFQLQK 358
E E++ ++ + ++++ ++ L+ E +E + ++E + +
Sbjct: 951 E---KLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAE 1007
Query: 359 TVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKR---ERSKR 415
V D +++ + S G + +K G ++ V+D S + E SK+
Sbjct: 1008 NVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ 1067
Query: 416 Q---------FKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQ 466
+ S + + EN + ++ K D +++
Sbjct: 1068 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 467 VNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQ-ESKFDKGQNS 525
V+++++ + + +++ LC+ KE+ I ++E+ L K HQ E + K Q
Sbjct: 1128 VDQVRE------YMENEKDKALCSLKEELIFAQEEKIKELQ----KIHQLELQTMKTQE- 1176
Query: 526 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT----ANLSTKDNGNL 581
T ++ K +I KL+K +++ + V E++T ++ +D N
Sbjct: 1177 -TGDEGKPLH--LLIGKLQK---AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS 1230
Query: 582 CDYGTHN-ILDLKKYVTDIQPSEQN-ESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVH 639
DY + N +L+ Y ++Q ++N + +NK+ ++ N+ + + ++ ++
Sbjct: 1231 GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIW--------- 1281
Query: 640 GLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVL---GLQKQIT 696
G + + E+ P E +S Q+ L D ++ + L L++Q+
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQ 1341
Query: 697 NMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD------ 750
+ + + + K+ Q + + + ++ ++ ++ S+ +T+ D
Sbjct: 1342 ELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMY 1401
Query: 751 -----KEIIPGNLEDPSEF------ETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQ 799
K+ I G +E EF L K + E+ V+ V +
Sbjct: 1402 PGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVI-VSMSIAFAQQTE 1460
Query: 800 NDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVT 859
G K +++ + + Q Y N+ K L +D T ET+ +++
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMK----LSQDQIGFQT---FETV--DVKFK 1511
Query: 860 NEFQTVDLLIKDNGN---LCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEI 916
EF+ + + ++G L + D +I E K V ++ K +R ++
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH----- 1566
Query: 917 ISEMNQIYEDNDKDAHVQESYTKDLDFK-VNKSKQKLECQDIINKHYMEVNSNEKESCDQ 975
E++ D + + E +D+ + V + ++ + +++ + +M ++E +Q
Sbjct: 1567 -DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ 1625
Query: 976 ILDSYKVVKKR-KKESSCKAKNILTKAKNKLASQLTESSQTSIS----LESDLKHITSEA 1030
+ + K + ++ + SS +N++++ + L +L Q S++ L +L++ +++
Sbjct: 1626 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQT 1685
Query: 1031 DSDPGNPVEL-CKTQKQSTTTLNKKDLP 1057
+ N E+ +T K+ +D+P
Sbjct: 1686 QNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Score = 35.0 bits (79), Expect = 0.45
Identities = 187/1055 (17%), Positives = 405/1055 (38%), Gaps = 139/1055 (13%)
Query: 62 AQALSREKENSRR----ITTEKMLLQKEVEKLNFENTFLR-------LKLNNLNKKLID- 109
A +LS E ++ + + EK+ L+++VE N E TF++ K+N L ++L
Sbjct: 2366 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425
Query: 110 ---------IEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQC----------- 149
I+++ N++ AI+ S + + +L+ K + Q
Sbjct: 2426 KRERESVEKIQSIPENSVNVAIDHLS-KDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2484
Query: 150 KLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFL 209
++ L + L S +D E QC IK D+ G Q +E+L
Sbjct: 2485 SIINLETRLLQLESTVSA-KDLELTQCYKQIK-----DMQEQG--------QFETEMLQK 2530
Query: 210 K-ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKT-SLMSEMRNAQSIGRRWEKPSP 267
K N Q + + + S + + + ++ Q ++T S E N Q++ + E
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2590
Query: 268 SNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTN-----ETNTEM 322
S+++ R S ES + T + +L+K+ + E N + E N +
Sbjct: 2591 SDISALTLRISELESQVVEMHT--SLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2648
Query: 323 QRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGI 382
QR K+ + E + E++ F + A+ T +E++ + +
Sbjct: 2649 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFN-ELEALRAESVATKAELASYKEKAEKL 2707
Query: 383 KKK-SNKKTNEHGM-KTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLD 440
+++ K+TN + K +V+D +E K + S + ++ ++V +K L
Sbjct: 2708 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2767
Query: 441 GKRGAEDPGFIFNNEQLAQMNE--QLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
++ G + +++ N+ Q+ N ++ LQ+ + ++ EK
Sbjct: 2768 KSIASQTDGTL----KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM 2823
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCN--KSKASRQTFVIHKLEKDNLLPNQKDKV 556
++ + + E++ K ++ + K + VI L K+
Sbjct: 2824 QELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL-------RSKEGS 2876
Query: 557 TIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKV 616
+I E L ++ + T + + D+G+ G + + E++ES + KK+
Sbjct: 2877 SIPE-LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKI 2935
Query: 617 --------NRKTEIISGMNHMYEDNDKDVVH-----GLKKGNFFFKTQEDKEPISENIEV 663
N +++S Y D + + L++ + T + + +++
Sbjct: 2936 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 2995
Query: 664 SKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR--KTE 721
+E ++ S++ +E+ D+R + +L LQ+ + S + R ++ T+
Sbjct: 2996 QREAEVYD-SSQSHESFSDWRGELLLALQQVFL------EERSVLLAAFRTELTALGTTD 3048
Query: 722 IISEVNHLD---NDKSIEYTVKSHSLFLTQKDKEIIPGNLE--------DPSEFETPALS 770
+ +N L+ ++ +EY L + D+ + ++ + S
Sbjct: 3049 AVGLLNCLEQRIQEQGVEYQAAMEC--LQKADRRSLLSEIQALHAQMNGRKITLKREQES 3106
Query: 771 TKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLN-----VCQKSEIIPETNQI 825
K S L + IQ ++ + D + +L+ V + + +T
Sbjct: 3107 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3166
Query: 826 YENDNKGVH-DLEKDNFFSLTPKDK--------ETISENLQVTNEFQTVDLLIKDNGNLC 876
E K H L++ F L KDK +T++ + + E Q L K+ L
Sbjct: 3167 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA--LEKEKAKLG 3224
Query: 877 DYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDK--DAHVQ 934
+ ++ EL+ +S +Q ++N L + + ++++E Q E DA +
Sbjct: 3225 RSEERDKEELEDLKFSLESQKQRNLQLNLL---LEQQKQLLNESQQKIESQRMLYDAQLS 3281
Query: 935 ESYTKDLDFKVNKSKQKLECQDIINK-------HYMEVNSNEKESCDQILDSYKVVKKRK 987
E ++L+ +V +K+ +++ + H +S+ L S ++K+ +
Sbjct: 3282 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3341
Query: 988 KESSCKAKNILTKAKNKLASQLTESSQTSISLESD 1022
K+ K I+ + N+ +S QT +E D
Sbjct: 3342 KQLEEKHSRIV-ELLNETEKYKLDSLQTRQQMEKD 3375
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 52.8 bits (125), Expect = 2e-06
Identities = 189/1066 (17%), Positives = 421/1066 (39%), Gaps = 165/1066 (15%)
Query: 27 KTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA--LAQALSREKENSRRITTEKMLL-- 82
++ KL + ++ L NS+ H++ A L QA + + +++ + LL
Sbjct: 234 QSQKLQIQFQQLQASETLRNST-------HSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Query: 83 -QKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASK 141
QK+ E + +FL+ K+ K+ ++E +E S+ E + ++
Sbjct: 287 YQKKKEDFTMQISFLQEKI-----KVYEMEQDKK------VENSNKEEIQEKETIIEELN 335
Query: 142 KKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQ 201
K I ++ K + L + LT+ D + ++ N + K + ++ + S++
Sbjct: 336 TKIIEEEKKTLEL---KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 202 DNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRR 261
+ +++ E Q DS+ + IV +E+ +Q + EM Q + +
Sbjct: 393 EIKQLMGTVEELQK-RNHKDSQFETDIVQRMEQETQRKLEQLRAE--LDEMYGQQIVQMK 449
Query: 262 WE--KPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETN 319
E + + + E K R N L + + D+ + + +N E+N +TN
Sbjct: 450 QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN---ELNIKLQDTN 506
Query: 320 TEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVS 379
++ ++ K++L GL E + LQ+ + D +L+ S +I
Sbjct: 507 SQKEKLKEEL-GLILE----------------EKCALQRQLEDLVEELSFSR-EQIQRAR 548
Query: 380 TGIKKKSNKKTNEH-GMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDV 438
I ++ +K H + T +K R + + K+ ++V N + ++
Sbjct: 549 QTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV------TNYKIKLEM 602
Query: 439 LDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
L+ ++ N L +M E +Q EL+++ Q F E L KE
Sbjct: 603 LEKEK----------NAVLDRMAE--SQEAELERLRTQLLF---SHEEELSKLKEDLEIE 647
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTI 558
+ L + G H + + D QN ++ Q + EKDNL+ Q +
Sbjct: 648 HRINIEKLKDNLG-IHYKQQIDGLQNEMS--------QKIETMQFEKDNLITKQNQLILE 698
Query: 559 YENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNR 618
L + + +++K + T I +L+K + ++ E+ + + + +++
Sbjct: 699 ISKL---KDLQQSLVNSKS-----EEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 619 KTEIISGMNHMYEDNDKDVVHGLKKGNFFF----KTQED----KEPISENIEV------- 663
KTE++ E++ ++ L+ N KT ED P+S+ +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 664 --------SKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVN-KKLRQ 714
KE++I D + QC + + +KQ N + + +VN ++L++
Sbjct: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI---EKQ-RNTFSFAEKNFEVNYQELQE 866
Query: 715 KVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPS----EFETPALS 770
+ ++ ++ N + +EY K +L + I P ++ S E +T
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
Query: 771 TKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQK-SEIIPETNQIYEND 829
T + G + + + ++ ++ K+ +L + Q+ S++ + Q
Sbjct: 927 TLEMGEVVEKDTTELM-------------EKLEVTKREKLELSQRLSDLSEQLKQ----- 968
Query: 830 NKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK----DNGNLCDYDTQNILE 885
+ L + K E QV+ + ++++I +N CD ++L+
Sbjct: 969 -------KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 886 LKKYVTDRKSAEQNESKINKL---RNKVNWKTEIISEMNQIYEDNDKDAHVQE---SYTK 939
+T R AE + SK+NK +K+ + ++ E + E++ ++ + + S TK
Sbjct: 1022 GVVTMTSR-GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 940 DLDFKVNKSKQKLECQDIIN-----KHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKA 994
+ + + + + Q +N ++ + + + C ++ S V + R+ + K
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 995 KNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVEL 1040
K + + + + +Q + + + +L+ + ++ D G P+ L
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Score = 48.1 bits (113), Expect = 5e-05
Identities = 72/339 (21%), Positives = 143/339 (42%), Gaps = 40/339 (11%)
Query: 896 AEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKL--- 952
+E ++ +L N + KT+ SE+ E +D + + L+F+V + +Q L
Sbjct: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS 2163
Query: 953 -----ECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLAS 1007
+ +D KH+ V + + S + L + + RK++ + L + + +L +
Sbjct: 2164 ADTFQKVED--RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
Query: 1008 QLTESSQTSISLESDLKHITSEAD---------SDPGNPVELCKTQKQSTTTLNKKDL-- 1056
+ E Q + LE K T+ D + L + + +T ++ L
Sbjct: 2222 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2281
Query: 1057 PFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILD-SVQGKSTVSEQADK 1115
F + I+E E ++ ++N+ +K +++ + E E I D Q + +S+Q
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2341
Query: 1116 ENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKEN 1175
+ N E E ++ + K + L+ I Q +S ++ S+ +V+I E
Sbjct: 2342 KRNREEE--IEQLNEVIEKLQQELANIG----QKTSMNAHSLSEEADSLKHQLDVVIAEK 2395
Query: 1176 FALECSPAFQVSDDEHEKMNKMK-------FKVNRRTQK 1207
ALE Q + +E+M MK FK+N+ TQ+
Sbjct: 2396 LALE-----QQVETANEEMTFMKNVLKETNFKMNQLTQE 2429
Score = 43.5 bits (101), Expect = 0.001
Identities = 87/476 (18%), Positives = 180/476 (37%), Gaps = 77/476 (16%)
Query: 821 ETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDT 880
E ++ EN NK ++ L K E + L++ ++ T D L+ +
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 881 QNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKD 940
Q I +K +T+ K E+ S+ K +++ + ++ + N KD+ + +
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIK---------QLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 941 LDFKVNKSKQKLEC--------------QDIINKHYM---EVNSNEKESCDQILDSYKVV 983
++ + + ++L Q++I +H E+ + K + L SY +
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
Query: 984 KKRKKESSCKAKNI-----------LTKAKNKLASQLTESSQTSISLESDLKHITSEADS 1032
E K N+ K KL +L + +L+ L+ + E
Sbjct: 482 --TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 1033 DPGNPVELCKTQKQSTTTLNK--KDLPFVEEIK-----------------EGECQVKKVN 1073
+T + + LN+ K L VE++K E E K+
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI- 598
Query: 1074 KMTSKSKKRKTSIDPSPESHEV-MERILDSV-----QGKSTVSEQADKENNLENEKMVKN 1127
K+ K++ +D ES E +ER+ + + S + E + E+ + EK+ N
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 658
Query: 1128 KPDFYTKAFRSLSEIHSPNIQDSSFDS----VREGLVPLSVSSGKNVIIKENFALECSPA 1183
Y + L S I+ F+ ++ + L +S K+ ++++ S
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKD--LQQSLVNSKSEE 716
Query: 1184 FQVSDDEHEKMNKMKFKVNRRTQK-SGIGDRPLQDLS-NTSFVSNNTAESENKSED 1237
+ +E +K + ++ R+ +K G ++ +Q+L T + E EN ++
Sbjct: 717 MTLQINELQK----EIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Score = 38.1 bits (87), Expect = 0.054
Identities = 188/1108 (16%), Positives = 436/1108 (39%), Gaps = 150/1108 (13%)
Query: 21 KDKRISKTTKLNVSLASKIKT--KILNNSSIFKISLKHNNRALAQALSREKENSRRITTE 78
KD I+K +L + + SK+K + L NS +++L+ N L +E E R+ E
Sbjct: 685 KDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE------LQKEIEILRQEEKE 737
Query: 79 KMLLQKEVEKLNFENTFLRLKL----NNLNKKLIDIEA---LMNNNLITAIEM----SSL 127
K L++EV++L + L ++ N+L +K +EA ++ + T +M + +
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV 797
Query: 128 SEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPD 187
S+ + FL S K + S K + + ++ED ++ +Q + I+ +
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEK-------EIEILIEENEDLKQQCIQLNEEIEKQR--- 847
Query: 188 IPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIV----DVPPRESHSHSDQS 243
E N V + E + ++ D+ ++ +
Sbjct: 848 -----------------NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
Query: 244 SKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSP 303
SK ++E + Q I K S E K + + +++K ++
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 304 ELNCNNEINGHTNETNTEMQRNKQDLPGLSSE-----SAREPNAECMNQIEDNDDFQLQK 358
E E++ ++ + ++++ ++ L+ E +E + ++E + +
Sbjct: 951 E---KLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAE 1007
Query: 359 TVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKR---ERSKR 415
V D +++ + S G + +K G ++ V+D S + E SK+
Sbjct: 1008 NVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ 1067
Query: 416 Q---------FKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQ 466
+ S + + EN + ++ K D +++
Sbjct: 1068 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 467 VNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQ-ESKFDKGQNS 525
V+++++ + + +++ LC+ KE+ I ++E+ L K HQ E + K Q
Sbjct: 1128 VDQVRE------YMENEKDKALCSLKEELIFAQEEKIKELQ----KIHQLELQTMKTQE- 1176
Query: 526 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT----ANLSTKDNGNL 581
T ++ K +I KL+K +++ + V E++T ++ +D N
Sbjct: 1177 -TGDEGKPLH--LLIGKLQK---AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS 1230
Query: 582 CDYGTHN-ILDLKKYVTDIQPSEQN-ESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVH 639
DY + N +L+ Y ++Q ++N + +NK+ ++ N+ + + ++ ++
Sbjct: 1231 GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIW--------- 1281
Query: 640 GLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVL---GLQKQIT 696
G + + E+ P E +S Q+ L D ++ + L L++Q+
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQ 1341
Query: 697 NMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD------ 750
+ + + + K+ Q + + + ++ ++ ++ S+ +T+ D
Sbjct: 1342 ELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMY 1401
Query: 751 -----KEIIPGNLEDPSEF------ETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQ 799
K+ I G +E EF L K + E+ V+ V +
Sbjct: 1402 PGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVI-VSMSIAFAQQTE 1460
Query: 800 NDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVT 859
G K +++ + + Q Y N+ K L +D T ET+ +++
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMK----LSQDQIGFQT---FETV--DVKFK 1511
Query: 860 NEFQTVDLLIKDNGN---LCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEI 916
EF+ + + ++G L + D +I E K V ++ K +R ++
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH----- 1566
Query: 917 ISEMNQIYEDNDKDAHVQESYTKDLDFK-VNKSKQKLECQDIINKHYMEVNSNEKESCDQ 975
E++ D + + E +D+ + V + ++ + +++ + +M ++E +Q
Sbjct: 1567 -DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ 1625
Query: 976 ILDSYKVVKKR-KKESSCKAKNILTKAKNKLASQLTESSQTSIS----LESDLKHITSEA 1030
+ + K + ++ + SS +N++++ + L +L Q S++ L +L++ +++
Sbjct: 1626 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQT 1685
Query: 1031 DSDPGNPVEL-CKTQKQSTTTLNKKDLP 1057
+ N E+ +T K+ +D+P
Sbjct: 1686 QNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Score = 35.0 bits (79), Expect = 0.45
Identities = 187/1055 (17%), Positives = 405/1055 (38%), Gaps = 139/1055 (13%)
Query: 62 AQALSREKENSRR----ITTEKMLLQKEVEKLNFENTFLR-------LKLNNLNKKLID- 109
A +LS E ++ + + EK+ L+++VE N E TF++ K+N L ++L
Sbjct: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
Query: 110 ---------IEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQC----------- 149
I+++ N++ AI+ S + + +L+ K + Q
Sbjct: 2434 KRERESVEKIQSIPENSVNVAIDHLS-KDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2492
Query: 150 KLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFL 209
++ L + L S +D E QC IK D+ G Q +E+L
Sbjct: 2493 SIINLETRLLQLESTVSA-KDLELTQCYKQIK-----DMQEQG--------QFETEMLQK 2538
Query: 210 K-ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKT-SLMSEMRNAQSIGRRWEKPSP 267
K N Q + + + S + + + ++ Q ++T S E N Q++ + E
Sbjct: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598
Query: 268 SNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTN-----ETNTEM 322
S+++ R S ES + T + +L+K+ + E N + E N +
Sbjct: 2599 SDISALTLRISELESQVVEMHT--SLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656
Query: 323 QRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGI 382
QR K+ + E + E++ F + A+ T +E++ + +
Sbjct: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFN-ELEALRAESVATKAELASYKEKAEKL 2715
Query: 383 KKK-SNKKTNEHGM-KTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLD 440
+++ K+TN + K +V+D +E K + S + ++ ++V +K L
Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2775
Query: 441 GKRGAEDPGFIFNNEQLAQMNE--QLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
++ G + +++ N+ Q+ N ++ LQ+ + ++ EK
Sbjct: 2776 KSIASQTDGTL----KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM 2831
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCN--KSKASRQTFVIHKLEKDNLLPNQKDKV 556
++ + + E++ K ++ + K + VI L K+
Sbjct: 2832 QELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL-------RSKEGS 2884
Query: 557 TIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKV 616
+I E L ++ + T + + D+G+ G + + E++ES + KK+
Sbjct: 2885 SIPE-LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKI 2943
Query: 617 --------NRKTEIISGMNHMYEDNDKDVVH-----GLKKGNFFFKTQEDKEPISENIEV 663
N +++S Y D + + L++ + T + + +++
Sbjct: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
Query: 664 SKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNR--KTE 721
+E ++ S++ +E+ D+R + +L LQ+ + S + R ++ T+
Sbjct: 3004 QREAEVYD-SSQSHESFSDWRGELLLALQQVFL------EERSVLLAAFRTELTALGTTD 3056
Query: 722 IISEVNHLD---NDKSIEYTVKSHSLFLTQKDKEIIPGNLE--------DPSEFETPALS 770
+ +N L+ ++ +EY L + D+ + ++ + S
Sbjct: 3057 AVGLLNCLEQRIQEQGVEYQAAMEC--LQKADRRSLLSEIQALHAQMNGRKITLKREQES 3114
Query: 771 TKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLN-----VCQKSEIIPETNQI 825
K S L + IQ ++ + D + +L+ V + + +T
Sbjct: 3115 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
Query: 826 YENDNKGVH-DLEKDNFFSLTPKDK--------ETISENLQVTNEFQTVDLLIKDNGNLC 876
E K H L++ F L KDK +T++ + + E Q L K+ L
Sbjct: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA--LEKEKAKLG 3232
Query: 877 DYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDK--DAHVQ 934
+ ++ EL+ +S +Q ++N L + + ++++E Q E DA +
Sbjct: 3233 RSEERDKEELEDLKFSLESQKQRNLQLNLL---LEQQKQLLNESQQKIESQRMLYDAQLS 3289
Query: 935 ESYTKDLDFKVNKSKQKLECQDIINK-------HYMEVNSNEKESCDQILDSYKVVKKRK 987
E ++L+ +V +K+ +++ + H +S+ L S ++K+ +
Sbjct: 3290 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
Query: 988 KESSCKAKNILTKAKNKLASQLTESSQTSISLESD 1022
K+ K I+ + N+ +S QT +E D
Sbjct: 3350 KQLEEKHSRIV-ELLNETEKYKLDSLQTRQQMEKD 3383
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 52.0 bits (123), Expect = 4e-06
Identities = 143/767 (18%), Positives = 298/767 (38%), Gaps = 94/767 (12%)
Query: 493 EKRITNEQEETYSLSQSSGKFHQE-------------------SKFDKGQNSLTCNKSKA 533
E + NE+EE L++ F QE S +D L KSK
Sbjct: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
Query: 534 SRQTFVIHKLEKD---------------NLLPNQKDKVTIYENLDVTNEFHTANLSTKDN 578
Q I KL + L+ + D++ +++ + NL N
Sbjct: 915 QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSN 974
Query: 579 GNLCDYGTHNILDL--KKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKD 636
G+ D + LDL Y+ Q E ++ NR+ S + ++E+ +
Sbjct: 975 GSEEDNLPNTQLDLLGNDYLVSKQVKEYR-------IQEPNRENSFHSSIEAIWEECKEI 1027
Query: 637 VVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQ---- 692
V KK + + ++ E + ++ K+ + L ++++NQ D + +Q
Sbjct: 1028 VKASSKKSHQIEELEQQIEKLQAEVKGYKD-ENNRLKEKEHKNQDDLLKEKETLIQQLKE 1086
Query: 693 ----KQITNMYPVQQ--NESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFL 746
K +T +Q + +L Q V I E+ + + +E SHS L
Sbjct: 1087 ELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVEC---SHSAKL 1143
Query: 747 TQK--DKEII----PGNLEDPSEFETPALSTKDSGNLYDSEIQNVLG--VKHGHDMQPAC 798
Q +KE I NL++ E ++ N+ + +++ + + DM+
Sbjct: 1144 EQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLL 1203
Query: 799 QNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQV 858
Q + + R + E + ++ +N + E+D + L KE +++ +
Sbjct: 1204 QLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED-YADL----KEKLTDAKKQ 1258
Query: 859 TNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIIS 918
+ Q +++D L N LE KK ++ + + I +L+ ++N + +
Sbjct: 1259 IKQVQKEVSVMRDEDKLLRIKI-NELEKKKNQCSQE-LDMKQRTIQQLKEQLN--NQKVE 1314
Query: 919 EMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILD 978
E Q YE KD +V+E +D+ + + +Q QD + +E E E L+
Sbjct: 1315 EAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV----LEAKLEEVERLATELE 1370
Query: 979 SYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPV 1038
+K +K + + KN + NK T+ +L+ +L+ + ++D +
Sbjct: 1371 KWK-----EKCNDLETKN--NQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWL 1423
Query: 1039 E----LCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHE 1094
E L K++ NK+ + E+ + Q ++ +T++ ++ + + E +
Sbjct: 1424 EEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERD 1483
Query: 1095 VMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDS 1154
+ L+ +Q K+ +S K+N +E K + ++ +K + +I I + D
Sbjct: 1484 QLVAALE-IQLKALISSNVQKDNEIEQLKRIISET---SKIETQIMDIKPKRISSADPDK 1539
Query: 1155 VREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKV 1201
++ + S +N I + L+ S +D+ + K + ++
Sbjct: 1540 LQTEPLSTSFEISRNKIEDGSVVLD-SCEVSTENDQSTRFPKPELEI 1585
Score = 39.3 bits (90), Expect = 0.024
Identities = 48/259 (18%), Positives = 113/259 (43%), Gaps = 21/259 (8%)
Query: 881 QNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKD 940
++++E + V + ++AE+ ++ KL ++ KT ++ +E+ K + E K
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKK 586
Query: 941 LDFKVNKSKQKLECQDIINKHYMEVNSN-----EKESCDQILDSYKVVKKRKKESSCKAK 995
L +N+ K+KL + I + + + E + + +L +++++ + K
Sbjct: 587 L---INEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFK 643
Query: 996 NILTK------AKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTT 1049
+++ K A + + E+ + + LE I +E G EL KT+++
Sbjct: 644 DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKG---ELIKTKEELKK 700
Query: 1050 TLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTV 1109
N+ D I+E E KK+ + K+ ID ++ + + ++
Sbjct: 701 RENESD----SLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKC 756
Query: 1110 SEQADKENNLENEKMVKNK 1128
+++AD + + N K++ N+
Sbjct: 757 NDKADTSSLIINNKLICNE 775
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 51.6 bits (122), Expect = 5e-06
Identities = 149/821 (18%), Positives = 327/821 (39%), Gaps = 123/821 (14%)
Query: 220 DDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMR-NAQSIGRR----WEKPSPSNVTER- 273
+D+ + S DV RE ++ + SL R + Q+I + + K SP ++ +
Sbjct: 144 EDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSD 203
Query: 274 -KKRGSSWESNNLSADTPCATVLDKQHIS--SPELNCNNEINGHTNETNTEMQRNKQDLP 330
+ R +SW NL + P +S +P+ + + H + + ++ + D+
Sbjct: 204 IEARLNSW---NLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMK 260
Query: 331 GLSSESAREPNAECMNQIED----------NDDFQLQKTVYDADMDLTASEVSKIVT-VS 379
E+ + Q D N++ + KT+Y + T + K+ V
Sbjct: 261 TKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQ 320
Query: 380 TGIKK-KSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDV 438
T I+ + ++T E + +K+ + S+E +++ N+ EK + + + ++
Sbjct: 321 TLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTEN 380
Query: 439 LDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITN 498
+ + ED N + M + + + +K++ + G+ EN N + +++
Sbjct: 381 I--QELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAEN--SNLQRQKLIQ 436
Query: 499 EQEETYSLSQSSGKFHQESKFDKGQNSLTCNKS---KASRQTFVIHKLEKDNLLPNQKDK 555
E+ E Q +TC++ KA R T +HK EKD+L+ + +
Sbjct: 437 EKAELERCYQ-----------------ITCSELQEVKARRNT--LHK-EKDHLVNDYEQN 476
Query: 556 VTIYE-----NLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNIN 610
+ + + ++++ + H LS ++ + N+ LK+ +Q SE
Sbjct: 477 MKLLQTKYDADINLLKQEHA--LSASKASSMIEELEQNVCQLKQ---QLQESELQRKQ-- 529
Query: 611 KLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGN---------FFFKTQEDKEPISENI 661
+LR + N+ S + H+YE D+ L KG F +E +E ++
Sbjct: 530 QLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVT 589
Query: 662 EVSK-ELQIPALSTRDNENQCDYRTQNVLGLQKQ--------ITNMYPVQQNESK----- 707
EV + + Q + + + Q + ++ V K+ +T +++ +SK
Sbjct: 590 EVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ 649
Query: 708 ---VNKKLRQK-VNRKTEIISEVNHLDNDKSIEYT--VKSHSLFLTQKDKEIIPGNLEDP 761
+ ++ Q+ V K E E HL + E V+ H + +K++ N+E
Sbjct: 650 LEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHE 709
Query: 762 SEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPE 821
++ + +D+ + D E Q H ++ N + Q+ + + E
Sbjct: 710 NQIQE--FKKRDAQVIADMEAQV-------HKLREELINVNS----------QRKQQLVE 750
Query: 822 TNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYD-- 879
+ E + + E + + + E + L+ T+ +T L K N L +
Sbjct: 751 LGLLREEEKQRA-TREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKE 809
Query: 880 --------TQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDA 931
+Q I EL+ ++ K E ++ ++ R + + + E Q+ DND+
Sbjct: 810 YTQKLAKSSQIIAELQTTISSLKE-ENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAI 868
Query: 932 HVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKES 972
V + ++ +V +++KL+ +++ ++ + E E+
Sbjct: 869 KVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYET 909
Score = 47.0 bits (110), Expect = 1e-04
Identities = 128/735 (17%), Positives = 278/735 (37%), Gaps = 109/735 (14%)
Query: 69 KENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAI-----E 123
+E+ + IT + + + ++ +++ + +LN+ N + + L + ++
Sbjct: 177 REDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFS 236
Query: 124 MSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSK 183
+ S FH FL S ++K + + K+M F L D D +K+ N + +
Sbjct: 237 LRKSSSFHDDHFL-SRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIE 295
Query: 184 TLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQS 243
L T S Q +E K + + D + I + DQ
Sbjct: 296 EL--------KTLYRSKQHETEETIRKLEKKVQTLIRDCQVI----------RETKEDQI 337
Query: 244 SKTSLMSEMRNAQSIGRRWEKPSPSNVTERKK-----------------RGSSWESNNLS 286
++ + E ++ +S+ WEK + V E ++ ++ N +
Sbjct: 338 AELKKICE-QSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKME 396
Query: 287 ADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLS------------- 333
++ T I E ++ G +N + Q+ Q+ L
Sbjct: 397 SEYMAQTQSTNHMIKELEARV-QQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV 455
Query: 334 ---SESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT 390
+ + +N E N +L +T YDAD++L E + + ++ + ++ +
Sbjct: 456 KARRNTLHKEKDHLVNDYEQN--MKLLQTKYDADINLLKQEHALSASKASSMIEELEQNV 513
Query: 391 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF 450
+ + + + + +K Q + S I EK + +S++ GK +
Sbjct: 514 CQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEK-KAHDLQSELDKGKEDTQKKIH 572
Query: 451 IFNNEQLAQMNEQLAQVNELKKMTLQ---TGFEQGDRENVLCNKKEKRITNEQEETY--S 505
F E L + EQL +V E++++ Q E+ R+ L ++K EQ E
Sbjct: 573 KF-EEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEAD 631
Query: 506 LSQSSGKFHQESK------------FDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQK 553
L++S ++SK +++ L + H EKD+L+ + +
Sbjct: 632 LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
Query: 554 DKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLR 613
++ ENL+ + AN+ + + I + KK D Q E+ ++KLR
Sbjct: 692 REI---ENLE--KQLRAANMEHE----------NQIQEFKK--RDAQVIADMEAQVHKLR 734
Query: 614 KKV-----NRKTEIIS-GMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKEL 667
+++ RK +++ G+ E H + ++++ K + + E+
Sbjct: 735 EELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEM 794
Query: 668 QIPALSTRDNENQCDY------RTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTE 721
+ +++ + + +Y +Q + LQ I+++ + ++ Q V +K E
Sbjct: 795 TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFE 854
Query: 722 IISEVNHLDNDKSIE 736
+ DND++I+
Sbjct: 855 DEKKQLIRDNDQAIK 869
Score = 41.2 bits (95), Expect = 0.006
Identities = 79/391 (20%), Positives = 165/391 (42%), Gaps = 47/391 (12%)
Query: 761 PSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIP 820
P TP S + S + +D + + K DM+ ++K ++ +L + QK +
Sbjct: 227 PVSLMTPKFSLRKSSSFHDDHFLSRIREKE-LDMKTKMM-EAKFHEE-KLKLQQKHDA-- 281
Query: 821 ETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDT 880
+ +I E N + +L K + S + +ETI + + + QT LI+D + +
Sbjct: 282 DVQKILERKNNEIEEL-KTLYRSKQHETEETIRK---LEKKVQT---LIRDCQVIRETKE 334
Query: 881 QNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD--AHVQESYT 938
I ELKK + ++ + N KL N V +EM Q D K ++QE
Sbjct: 335 DQIAELKK-ICEQSTESLNNDWEKKLHNAV-------AEMEQEKFDLQKQHTENIQE-LL 385
Query: 939 KDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNIL 998
+D + ++NK + + Q H ++ E E+ Q L +++ + K L
Sbjct: 386 EDTNVRLNKMESEYMAQTQSTNHMIK----ELEARVQQLTGEAENSNLQRQKLIQEKAEL 441
Query: 999 TKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKD--- 1055
+ S+L E +L + H+ ++ + + ++L +T+ + L K++
Sbjct: 442 ERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQN----MKLLQTKYDADINLLKQEHAL 497
Query: 1056 -----LPFVEEIKEGECQVKK-------VNKMTSKSKKRKTSIDPSPESHEVMERILDSV 1103
+EE+++ CQ+K+ K + ++ K ++ S H + E+ +
Sbjct: 498 SASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKH-IYEKKAHDL 556
Query: 1104 QGKSTVSEQADKENNLENEKMVKNKPDFYTK 1134
Q + ++ ++ + E+ +K K + T+
Sbjct: 557 QSELDKGKEDTQKKIHKFEEALKEKEEQLTR 587
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 51.2 bits (121), Expect = 6e-06
Identities = 184/988 (18%), Positives = 381/988 (38%), Gaps = 186/988 (18%)
Query: 306 NCNNEINGHTNETNTEMQR-NKQDLP---------GLSSESAREPNAECMNQIEDNDDFQ 355
NC N+I E + NK +L L EP ++ E +
Sbjct: 467 NCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKT-MIDLTEFRNSKH 525
Query: 356 LQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFR--------------KV 401
L++ Y A+ + E+ + +KKK + E G ++
Sbjct: 526 LKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ 585
Query: 402 KDSSSEKK------RERSKRQFKNS-SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNN 454
D SE+K + S+ Q KN ++ EK E ERS + K + + N
Sbjct: 586 GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEEN 644
Query: 455 EQLAQ-MNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKF 513
+QL + M E L + E++K G E L +R+ N E +
Sbjct: 645 KQLEEGMKEILQAIKEMQKDPDVKG-----GETSLIIPSLERLVNAIESKNAEGIFDASL 699
Query: 514 HQESKFDK--GQNSLTCNKSKASRQTFV------------IHKLEKD-NLLPNQKDKVTI 558
H +++ D+ G+N + + SR+ + I LEK+ +LL + +
Sbjct: 700 HLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
Query: 559 YENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINK------- 611
++ +D+ + ++ S ++ N +Y H + +L+ ++ E + + N+
Sbjct: 760 FKGIDLPDGIAPSSASIINSQN--EYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH 817
Query: 612 ---------LRKKVNRKTE--IISGMNHMYEDN-DKDVVHGLKKGNFFFKTQED----KE 655
L +K KTE I ED +D + + N Q D K+
Sbjct: 818 QQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKK 877
Query: 656 PISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQN-----ESKVNK 710
++EN LQ+ NE + ++ L++Q+ Q+N E++V +
Sbjct: 878 ILAENSRKITVLQV-------NEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
Query: 711 KL----------------RQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEII 754
K+ QKV + +SE+ L N + E T K + QKD ++
Sbjct: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSEL-ELANKQYNELTAKYRDIL--QKDNMLV 987
Query: 755 --PGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNV 812
NLE E +S K+ + E++ + + H ++ A + ++K+G + ++
Sbjct: 988 QRTSNLE---HLECENISLKEQVESINKELE--ITKEKLHTIEQAWEQETKLGNESSMDK 1042
Query: 813 CQK----SEIIPETNQI--------------------YENDNKGVHDLEKDNFFSLTPKD 848
+K S+I+ + +I YE+ + +E+ N F L K
Sbjct: 1043 AKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERN-FELETKF 1101
Query: 849 KETISENLQVTNEFQTVDLLIKD------NGNLCDYDTQNILELKKYVTDRKSAEQNESK 902
E NL + Q V+ +++D + + D D Q ILEL+K + + SK
Sbjct: 1102 AELTKINL----DAQKVEQMLRDELADSVSKAVSDADRQRILELEK---NEMELKVEVSK 1154
Query: 903 INKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHY 962
+ ++ + + EI++ Q +D V+ + LD++ ++ L + +++H
Sbjct: 1155 LREISDIARRQVEILNAQQQ-----SRDKEVESLRMQLLDYQAQSDEKSLIAK--LHQHN 1207
Query: 963 MEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESD 1022
+ + +E + + L+S ++ + + + + L + + L E + L
Sbjct: 1208 VSLQLSEATALGK-LESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT 1266
Query: 1023 LKHITSEADSDPGNPVELCKTQKQSTT--TLNKKDLPFVEEIKEGECQVKKVNKMTSKSK 1080
++ + + + L + +K S T L L ++E+K + + + + T + +
Sbjct: 1267 IQSLRRQF----SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
Query: 1081 KRKTSIDPSPESHEVMERILDSVQGKSTVS-----EQADKENNLENEKMVKNKPD----- 1130
+ ++ E++ + D+ + ++ E+ + N ++VK+K +
Sbjct: 1323 LKLKGLE------ELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLN 1376
Query: 1131 -FYTKAFRSLSEIHSPNIQDSSFDSVRE 1157
++ R++S + +Q + F R+
Sbjct: 1377 NIISEYERTISSLEEEIVQQNKFHEERQ 1404
Score = 44.3 bits (103), Expect = 7e-04
Identities = 186/999 (18%), Positives = 376/999 (37%), Gaps = 187/999 (18%)
Query: 125 SSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDE-----------DEDKEK 173
SSL++F Q+++ L + +RL + DD +D E+
Sbjct: 1594 SSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLER 1653
Query: 174 MQCDNNIKSKTLPDIPSSGSTTQPLSTQDN--SEVLFLKENNQNV-YGLDDSEHISSIVD 230
+ +K K +I L Q+N EV +K +++ Y LD S+ S +
Sbjct: 1654 QREITELKVKEFENIK--------LQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
Query: 231 VP---PRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTE-RKKRGSSWESNNLS 286
+E++S + ++ +L+ +++ ++ + +K + E R + ++ E +S
Sbjct: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
Query: 287 ADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMN 346
A + L+ Q I ++ HT E T+++ ++L L N E N
Sbjct: 1766 ATSQKEAHLNVQQI----------VDRHTRELKTQVEDLNENLLKLKEALKTSKNRE--N 1813
Query: 347 QIEDN-----DDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKV 401
+ DN ++ Q ++ Y+ + E +I + +K++ + T+ K
Sbjct: 1814 SLTDNLNDLNNELQKKQKAYNKIL----REKEEIDQENDELKRQIKRLTSGLQGKPLTDN 1869
Query: 402 KDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMN 461
K S E+ + + K K+EN+ L+GK D L M
Sbjct: 1870 KQSLIEELQRKVK-------------KLENQ------LEGKVEEVD---------LKPMK 1901
Query: 462 EQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDK 521
E+ A+ ++ +E+G + ++ ++ E ++L+ K
Sbjct: 1902 EKNAKEELIR-------WEEGKKWQAKIEGIRNKLKEKEGEVFTLT-------------K 1941
Query: 522 GQNSLTCNKSKASRQTFVIH-KLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGN 580
N+L +KA ++ + KL+ + +Q + E+ E NL +++
Sbjct: 1942 QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEND-- 1999
Query: 581 LCDYGTHNILDLKKYVTDIQPSEQN-ESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVH 639
+ H L V D+ + + ++ L K+ ++ T ++ + D+
Sbjct: 2000 ILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059
Query: 640 GLKKGNFFFKTQEDKEPISENIEVSKELQ-----IPALST--RDNENQCDYRTQNVLGLQ 692
L+K N SENIE+ +L+ +P L RD + C++ + +Q
Sbjct: 2060 ELQKENLKLS--------SENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111
Query: 693 KQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKE 752
+++ ++ ++ K +L + + +++ +V + E K+ + ++K
Sbjct: 2112 RKLGHVRGSGRS-GKTIPELEKTIGLMKKVVEKVQ-----RENEQLKKASGILTSEKMAN 2165
Query: 753 IIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNV 812
I N + +E E L GH + ++ +K +K
Sbjct: 2166 IEQENEKLKAELEK-------------------LKAHLGHQLSMHYESKTKGTEK----- 2201
Query: 813 CQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDN 872
II E ++ + K EK NL++ NE TV L ++
Sbjct: 2202 -----IIAENERLRKELKKETDAAEK----------LRIAKNNLEILNEKMTVQL--EET 2244
Query: 873 GNLCDYDTQNILELKKYVTDRKS------AEQNESKINKLRNKVNWKTEIISEMNQIYED 926
G + +L+ D KS E+K+ +L + K + I+++ Q+
Sbjct: 2245 GKRLQFAESRGPQLEG--ADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLV-- 2300
Query: 927 NDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKR 986
K+A +E KVNK + LE Q I KH E + ++ + L ++ +
Sbjct: 2301 --KEATEREQ-------KVNKYNEDLEQQIKILKHVPE-GAETEQGLKRELQVLRLANHQ 2350
Query: 987 KKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQ 1046
+ KA+ I NK S + + L+ +K + ++ L + K+
Sbjct: 2351 LDKE--KAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
Query: 1047 STTTLNKKDLPFVEEIKEGEC----QVKKVNKMTSKSKK 1081
L D F EEI++ + +VKK + K KK
Sbjct: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447
Score = 43.5 bits (101), Expect = 0.001
Identities = 157/867 (18%), Positives = 334/867 (38%), Gaps = 124/867 (14%)
Query: 406 SEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLA 465
+E +++K+ NS V I +KI + L+ ++ AE ++ + + L
Sbjct: 1036 NESSMDKAKKSITNSDIVSISKKITMLEMKE--LNERQRAEHCQKMYEH-----LRTSLK 1088
Query: 466 QVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNS 525
Q+ E + L+T F + + N+ K E+ + +E ++ S + S + + +K +
Sbjct: 1089 QMEE-RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEME 1147
Query: 526 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYG 585
L SK R+ I + + + L Q+ + E+L + + A K +
Sbjct: 1148 LKVEVSKL-REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSL--IAKLH 1204
Query: 586 THNILDLKKYVTDIQPSEQNESNINK-------LRKKVNRKTEII-----SGMNHMYEDN 633
HN+ T + E S + K L +K++ K + + G N +
Sbjct: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA--KH 1262
Query: 634 DKDVVHGLKK---GNFFFKTQE--DKEPI---SENIEVSKELQIPALSTRDNENQCDYRT 685
+ + L++ G QE K I ++ +++ +E++ R+ EN+
Sbjct: 1263 LRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
Query: 686 QNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYT---VKSH 742
+ GL++ I+ + + + +N ++ + R E+ + + + I+Y + +
Sbjct: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEY 1382
Query: 743 SLFLTQKDKEIIPGNL---EDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQ 799
++ ++EI+ N E ++ + + +++D + +L +
Sbjct: 1383 ERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSI 1442
Query: 800 NDSKIGKKPRLNVCQKS-----EIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISE 854
D + +L + + II ET K + + K+ +L ++ +S
Sbjct: 1443 PDPSLPLPNQLEIALRKIKENIRIILETRATC----KSLEEKLKEKESALRLAEQNILSR 1498
Query: 855 NLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKT 914
+ +V NE + + L + +E K + T K A Q I ++ ++N K
Sbjct: 1499 D-KVINELRLRLPATAEREKLIAELGRKEMEPKSHHT-LKIAHQT---IANMQARLNQKE 1553
Query: 915 EIIS-----------EMNQIYEDNDKDAHVQESYTK-DLDFKVNKSKQKLECQDII---- 958
E++ E +I + +++D H+ + D +NK KQ D++
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT--AWDLMKQSP 1611
Query: 959 -----NKHYMEVNSNEKESCDQILD-SYKVVKKRKKESSCKAKNILTKAKNK----LASQ 1008
NKH++ + E+ +Q S +VK +K + + +T+ K K + Q
Sbjct: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQ 1671
Query: 1009 LTESSQTSISLES----DLKHITSEADSDPGNPVELCKTQKQS-----TTTLNKKDLPFV 1059
L E+ + + DLK++ ++ + + QK++ TTT+
Sbjct: 1672 LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLK 1731
Query: 1060 EEIKEGECQVKKVNK--------MTSKSKKRKTSIDPSPESHEVMERILDS--------- 1102
++ E Q K +++ MT+ +++R S E+H +++I+D
Sbjct: 1732 SQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQV 1791
Query: 1103 --------------VQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQ 1148
K+ + D N+L NE K K Y K R EI N +
Sbjct: 1792 EDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKA--YNKILREKEEIDQENDE 1849
Query: 1149 -DSSFDSVREGLVPLSVSSGKNVIIKE 1174
+ GL ++ K +I+E
Sbjct: 1850 LKRQIKRLTSGLQGKPLTDNKQSLIEE 1876
Score = 40.4 bits (93), Expect = 0.011
Identities = 58/303 (19%), Positives = 126/303 (41%), Gaps = 29/303 (9%)
Query: 835 DLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRK 894
+L+K+N L+ ++ E + Q + + ++D +C++ + E+++ + +
Sbjct: 2060 ELQKENL-KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVR 2118
Query: 895 SAEQNESKINKLRNKVNWKTEIISEMNQIYED---------NDKDAHVQESYTKDLDFKV 945
+ ++ I +L + +++ ++ + E ++K A++++ K K
Sbjct: 2119 GSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEK---LKA 2175
Query: 946 NKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCK-----AKNILTK 1000
K K ++ HY S K + I ++ ++ K+ KKE+ AKN L
Sbjct: 2176 ELEKLKAHLGHQLSMHY---ESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI 2232
Query: 1001 AKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQ----KQSTTTLNKKDL 1056
K+ QL E+ + ES + ADS + + + K+ T + KK+
Sbjct: 2233 LNEKMTVQLEETGKRLQFAESRGPQLEG-ADSKSWKSIVVTRMYETKLKELETDIAKKNQ 2291
Query: 1057 PFVEE---IKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQA 1113
+ +KE + +KVNK +++ + PE E + + +Q + Q
Sbjct: 2292 SITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQL 2351
Query: 1114 DKE 1116
DKE
Sbjct: 2352 DKE 2354
Score = 38.1 bits (87), Expect = 0.054
Identities = 149/807 (18%), Positives = 302/807 (37%), Gaps = 139/807 (17%)
Query: 447 DPGFIFNNEQLAQ---MNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEET 503
DP + E+LA ++ +VNELK + L K + + EE
Sbjct: 14 DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73
Query: 504 YSLSQSSGKFHQE--SKFDKGQNSLT-CNKSKASRQT-FVIHKL--------EKDNLLPN 551
+ KF + +K K +N L +S R T F+ +++ +KD L +
Sbjct: 74 EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELED 133
Query: 552 QKDKVT----IYENLDVTNEFHTANLST---------KDNGNLCDYGTHNILDLKKYV-- 596
+ ++ + E L + NE S K N LC +I+D +K +
Sbjct: 134 MEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ----DIIDYQKQIDS 189
Query: 597 ---TDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQED 653
T + ++ ++L KK + + + + E N+K V + ++ ++
Sbjct: 190 QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQE 249
Query: 654 KEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLR 713
E +++ K + +N D + Q Q+ + + +++++ + +
Sbjct: 250 MEKMTDEYNRMKAI------VHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIM 303
Query: 714 QKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKD 773
VN K E + +D+ IEY H+L K+ ++
Sbjct: 304 VAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQL-------------------- 343
Query: 774 SGNLYDSEIQNVLGVKHG-----HDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYEN 828
D++ NV+ ++ G ++ + + K+ N C ++ E +
Sbjct: 344 -----DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---- 394
Query: 829 DNKGVHDLEKDNFFSLTP-----KDKETISENLQVTNEFQTVDLLIKDN------GNLCD 877
NKG L + + K+K +E T E D KD L D
Sbjct: 395 -NKGASTLSQQTHMKIQSTLDILKEKTKEAER---TAELAEADAREKDKELVEALKRLKD 450
Query: 878 YDT------QNILELKKYVTDRKSAEQNESKINKLRNKVNWK-TEIISEMNQIYEDNDKD 930
Y++ ++E+K K ++ + K NK+ K ++ + E + E +
Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLE 510
Query: 931 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES 990
T+ + K K +Q I+ K E+ S E+E D ++ ++R K S
Sbjct: 511 PKTMIDLTEFRNSKHLKQQQYRAENQILLK---EIESLEEERLDLKKKIRQMAQERGKRS 567
Query: 991 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNP------VELCKTQ 1044
A + LT L +++ + S + DL + + +++ N +E +
Sbjct: 568 ---ATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEFLSRELIEKERDL 623
Query: 1045 KQSTTTLNK---KDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEV------ 1095
++S T + K K VEE K+ E +K++ + + +K DP + E
Sbjct: 624 ERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQK-----DPDVKGGETSLIIPS 678
Query: 1096 MERILDSVQGKST---------VSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPN 1146
+ER++++++ K+ + Q D+ NE++ + + +A ++ N
Sbjct: 679 LERLVNAIESKNAEGIFDASLHLKAQVDQLTG-RNEELRQELRESRKEAINYSQQLAKAN 737
Query: 1147 IQDSSFDSVREGLVPLSVSSGKNVIIK 1173
++ D + + L S G NV+ K
Sbjct: 738 LK---IDHLEKETSLLRQSEGSNVVFK 761
Score = 36.2 bits (82), Expect = 0.20
Identities = 64/327 (19%), Positives = 130/327 (39%), Gaps = 49/327 (14%)
Query: 835 DLEKDNFFS-LTPKDKETISENLQVTNEFQT--VDLLIKDNGNLCDYDTQNILELKKYVT 891
DLE+ + L K+ E I LQ +E + V ++D L D + LK +
Sbjct: 1650 DLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ 1709
Query: 892 DRKSAEQNESKINKLRNKVN-WKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKV----N 946
+K A + + +RN V K+++ + Q + ++ T + ++ +
Sbjct: 1710 AQKEAN-SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATS 1768
Query: 947 KSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNI--------- 997
+ + L Q I+++H E+ + ++ + +L + +K K + N+
Sbjct: 1769 QKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
Query: 998 LTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLP 1057
KA NK+ + E Q + L+ +K +TS P T NK+ L
Sbjct: 1829 KQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP--------------LTDNKQSL- 1873
Query: 1058 FVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSP-ESHEVMERILDSVQGKSTVSEQADKE 1116
+EE++ +KV K+ ++ + + +D P + E ++ +GK ++
Sbjct: 1874 -IEELQ------RKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926
Query: 1117 NNLENE--------KMVKNKPDFYTKA 1135
N L+ + K + D + KA
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKA 1953
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 50.8 bits (120), Expect = 8e-06
Identities = 93/501 (18%), Positives = 206/501 (41%), Gaps = 54/501 (10%)
Query: 650 TQEDKEPISENIEVSKELQIPALSTRD-NENQCDYRTQNVLGLQKQITNMYPV-----QQ 703
T++ + P +E+ ++ + T++ N+N T N L+ ++ N+ + +
Sbjct: 427 TKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRT 486
Query: 704 NESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSE 763
+E ++++L+Q + + +EVN L+ + +K + L + +E + + + +E
Sbjct: 487 SEVYLHEELQQDMQK---FKNEVNTLEEEF---LALKKEDVQLHKDVEEEMEKHRSNSTE 540
Query: 764 FETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETN 823
GN D Q + ++G +PA D +K + K++I PE +
Sbjct: 541 LSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPA---DKTSNEKNEV----KNQIYPEAD 593
Query: 824 --------QIYENDNKGVHDLEKDNFFSLTPKDKETISENL---QVTNEFQTVDLLIKDN 872
+I D + H + +NF L + + ++ ++ + F + L+K
Sbjct: 594 FADSMEPSEIASEDCELSHSVY-ENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLK 652
Query: 873 GNLCDYDTQNILELKKYVTDRKSAEQNESKINKLR---NKVNWKTEIISEMNQIYEDNDK 929
N CD T + +++ V+ ++ E +E+K KL+ K+ W+ E+ + ++N++
Sbjct: 653 NNHCDQLTVKLKQMENMVSVLQN-ELSETKKTKLQLELQKIEWEKELYDLRLALKQENEE 711
Query: 930 DAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKE 989
+ Y KD + K + EC ++ E K + +++ + V+
Sbjct: 712 KRNADMLYNKDSEQLRIKEE---ECGKVV-----ETKQQLKWNLRRLVKELRTVRNN--- 760
Query: 990 SSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTT 1049
+++ + +N QL+E I + L E + + Q
Sbjct: 761 -----LDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEK 815
Query: 1050 TLNKKDLPFVEEIKEGECQVKKV-NKMTSKSKKRKTSIDPSPESHEVMERI--LDSVQGK 1106
L +D EEI ++ + N+ K KK I+ E ++ +++I L+
Sbjct: 816 DLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLT 875
Query: 1107 STVSEQADKENNLENEKMVKN 1127
T+ + + + NNL E + N
Sbjct: 876 ETILQYSGQLNNLTAENKILN 896
Score = 31.6 bits (70), Expect = 5.0
Identities = 83/428 (19%), Positives = 160/428 (37%), Gaps = 74/428 (17%)
Query: 84 KEVEKLNFEN---TFLRL--KLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSF--- 135
+++ KLN E T L+ +LNNL + ++N+ L + E S+
Sbjct: 864 QKIIKLNEETLTETILQYSGQLNNLTAE----NKILNSELENGKQNQERLEIEMESYRCR 919
Query: 136 LLSASKKKRISKQCKLMRLPFARVP---LTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSG 192
L +A + S+ + ++L F R + +D D +Q N I S+ L + S
Sbjct: 920 LAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKI 979
Query: 193 STTQ-----------------PLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRE 235
++ Q +D S+ K+ + +Y ++ S+ I E
Sbjct: 980 NSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVE 1039
Query: 236 SHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVL 295
QS L ++ +A EK S S + ++ + NL A++
Sbjct: 1040 ERLSQLQSENMLLRQQLDDAHKKANSQEKTS-STIQDQFHSAAK----NLQAES------ 1088
Query: 296 DKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLS---SESAREPNAECMNQIEDND 352
+KQ +S E N E+ N M + +++ G +E+ + C++ +N+
Sbjct: 1089 EKQILSLQEKN--KELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENE 1146
Query: 353 DFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRER 412
QLQ+T++ E + K K K +K++ + ++ K E
Sbjct: 1147 VLQLQQTLFSMKAIQKQCETLQ--------KNKKQLKQEVVNLKSYME-RNMLERGKAEW 1197
Query: 413 SKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKK 472
K + + +I EK+ + + +Q A +EQL Q+ E
Sbjct: 1198 HKLLIEERARKEIEEKL-----------------NEAILTLQKQAAVSHEQLVQLREDNT 1240
Query: 473 MTLQTGFE 480
+++T E
Sbjct: 1241 TSIKTQME 1248
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 50.4 bits (119), Expect = 1e-05
Identities = 121/593 (20%), Positives = 224/593 (37%), Gaps = 98/593 (16%)
Query: 626 MNHMYEDNDKDVVHGLKK-GNFFFKTQEDKEPISENIE--------VSKELQIPALSTRD 676
MN YE + +V G+++ + + + + N+ + +EL A ++
Sbjct: 628 MNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687
Query: 677 NENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVN--------- 727
E++ + +L L+KQ+ + + N +L Q++ K E I +
Sbjct: 688 LESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEK 747
Query: 728 -----------HLDNDKSIEYTVKSHSLFLTQKDKEIIPG----------------NLED 760
HL+ K +E ++ L +KD++ +LE
Sbjct: 748 ICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLES 807
Query: 761 PSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIP 820
T + N+ E L + + Q DS L +C K E++
Sbjct: 808 LDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA------LEIC-KEELVL 860
Query: 821 ETNQIYENDNKGVHDLEK--DNFFSLTPKDK-------ETISENLQVTNEFQTVDLLIKD 871
NQ+ N K L+K + + L + K ET +N+ + + Q +++
Sbjct: 861 HLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
Query: 872 ----NGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDN 927
NG L DTQ LE + +++ +Q ES KLR K+ K E + +E +
Sbjct: 921 ETIRNGEL--EDTQTKLEKQVSKLEQELQKQRESSAEKLR-KMEEKCE-----SAAHEAD 972
Query: 928 DKDAHVQE--SYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKK 985
K V E + + ++++ K++L + H N+ Q LD K
Sbjct: 973 LKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ-LDMILDQTK 1031
Query: 986 RKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQK 1045
+ E A L K ++ ++LTE+ Q LE++L++ E S EL +
Sbjct: 1032 TELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
Query: 1046 QSTTTLNK-----KDLPF------------VEEIKEGECQVKKVNKMTSKSKKRKTSIDP 1088
++ +L + KDL +E+ E + +K+ N + + T +D
Sbjct: 1092 KAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDM 1151
Query: 1089 SPESHE-VMERILDSVQGKSTVSEQADKENNLE----NEKMVKNKPDFYTKAF 1136
+ H ME+ + ++G SE KE N + N+K+ K K F
Sbjct: 1152 TIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEF 1204
Score = 42.0 bits (97), Expect = 0.004
Identities = 47/243 (19%), Positives = 106/243 (43%), Gaps = 24/243 (9%)
Query: 913 KTEIISEMNQIYEDNDK-----DAHVQESYTKDLDFKV-NKSKQKLECQDIINKHYMEVN 966
K E++ +NQ+ + +K +E Y + K+ N S Q+ Q++I +H ++
Sbjct: 855 KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ 914
Query: 967 SNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHI 1026
Q+L + +++ K + ++K + +L Q S++ +E +
Sbjct: 915 Q-------QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967
Query: 1027 TSEADSDPGNPVELCKTQKQSTTTLN--KKDLPFVEE-----IKEGECQVKKVNKMTSKS 1079
EAD +EL T +Q ++ K++L +E+ ++GE + ++++
Sbjct: 968 AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027
Query: 1080 KKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSL 1139
+ KT ++ + + +E++ S + + ++E K LE E ++N R L
Sbjct: 1028 DQTKTELEKKTNAVKELEKLQHSTE--TELTEALQKREVLETE--LQNAHGELKSTLRQL 1083
Query: 1140 SEI 1142
E+
Sbjct: 1084 QEL 1086
Score = 34.7 bits (78), Expect = 0.59
Identities = 123/711 (17%), Positives = 269/711 (37%), Gaps = 120/711 (16%)
Query: 82 LQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASK 141
+ K+ EK E L + L KLI IEA ++ + +S + Q L AS
Sbjct: 628 MNKQYEK---ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASN 684
Query: 142 KKRI----SKQC-KLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTL---PDIPSSGS 193
++ +K+C +L+ L E + +EK+ ++I +K ++
Sbjct: 685 SSKLESEMTKKCSQLLTL------------EKQLEEKIVAYSSIAAKNAELEQELMEKNE 732
Query: 194 TTQPLSTQDNSE-----VLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKT-- 246
+ L T N+E + F K ++ + E ++ + + KT
Sbjct: 733 KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMS 792
Query: 247 ----SLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWES--NNLSADTPCATVLDKQ-H 299
++ + + +S+ R + E K+ + ++ N +S +T LD
Sbjct: 793 MLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE 852
Query: 300 ISSPELNCN-NEINGHTNETNTEMQRNKQDLPGLSSE---------SAREPNAECMNQIE 349
I EL + N++ G+ + ++++ +++ L E E N + ++
Sbjct: 853 ICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ 912
Query: 350 DNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKK 409
Q+T+ + +++ T +++ K V+ +K + + E K K + ++ E
Sbjct: 913 QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEAD 972
Query: 410 RERSK--------RQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF------IFNNE 455
+R K RQ K D K E +++ KR E+ + ++
Sbjct: 973 LKRQKVIELTGTARQVKIEMD---QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
Query: 456 QLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQ 515
++ ++ V EL+K+ T + E +K + + E + + +S+ + Q
Sbjct: 1030 TKTELEKKTNAVKELEKLQHST-----ETELTEALQKREVLETELQNAHGELKSTLRQLQ 1084
Query: 516 ESK--FDKGQNSLTCNKSKASRQTFVIHK------------LEKDNLLPNQ----KDKVT 557
E + K Q SL + T + + LE D L + K +
Sbjct: 1085 ELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAA 1144
Query: 558 IYENLDVTNEFHTANLSTKD---NGNL---------CDYGTHNILD-LKKYVTDIQPSE- 603
+LD+T H + K G L C+ ++ D L+ ++ E
Sbjct: 1145 QVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEF 1204
Query: 604 ---QNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN 660
QNE I++L+K++ R + + M + ++ ++ + TQ E
Sbjct: 1205 IMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ-----------YIATQ-----YKEA 1248
Query: 661 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKK 711
I++ +EL++ +++ + + Q++I + ++ +++K+
Sbjct: 1249 IDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299
Score = 33.9 bits (76), Expect = 1.0
Identities = 39/212 (18%), Positives = 93/212 (43%), Gaps = 13/212 (6%)
Query: 879 DTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIIS------EMNQIYEDNDKDAH 932
+ +N LE + + K ESK ++ KV+ + + N+ + ++ +
Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368
Query: 933 VQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSC 992
+ Y K + K+ K + + E + + + N +E C +++K++ ++
Sbjct: 369 AFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKE 428
Query: 993 KAKN------ILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQ 1046
+ N I+ +++ +QLTES Q+ + LES+L++ E D + + + K
Sbjct: 429 ENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN-KDEILRDKFSLMNENRELKV 487
Query: 1047 STTTLNKKDLPFVEEIKEGECQVKKVNKMTSK 1078
N++ +EI+ +++ + K+ S+
Sbjct: 488 RVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,609,759
Number of Sequences: 37866
Number of extensions: 2021051
Number of successful extensions: 9124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 440
Number of HSP's that attempted gapping in prelim test: 7899
Number of HSP's gapped (non-prelim): 1541
length of query: 1265
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1151
effective length of database: 13,930,794
effective search space: 16034343894
effective search space used: 16034343894
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.