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Search of human proteins with 229892270
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|229892270 WD repeats and SOF1 domain containing [Homo
sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens] 1240 0.0
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 66 1e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 66 1e-10
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 66 1e-10
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 66 1e-10
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 65 1e-10
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 65 1e-10
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 65 2e-10
gi|89886480 zinedin isoform 2 [Homo sapiens] 63 7e-10
gi|89886477 zinedin isoform 1 [Homo sapiens] 63 7e-10
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 62 2e-09
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 62 2e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens] 61 3e-09
gi|19913365 transducin beta-like 1Y [Homo sapiens] 61 3e-09
gi|15150805 transducin beta-like 1Y [Homo sapiens] 61 3e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 61 3e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 61 3e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 60 4e-09
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 60 4e-09
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 60 4e-09
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 60 4e-09
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 59 1e-08
gi|5902034 periodic tryptophan protein 1 [Homo sapiens] 59 1e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 58 2e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 58 2e-08
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 57 6e-08
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 57 6e-08
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 57 6e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 56 8e-08
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 55 2e-07
>gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens]
Length = 597
Score = 1240 bits (3209), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MQWPPPWRRSPLVSATPPPGPTRGLLCPRRVSEAGDSSTEGARTGHRHYVTPAESAMEGR 60
MQWPPPWRRSPLVSATPPPGPTRGLLCPRRVSEAGDSSTEGARTGHRHYVTPAESAMEGR
Sbjct: 1 MQWPPPWRRSPLVSATPPPGPTRGLLCPRRVSEAGDSSTEGARTGHRHYVTPAESAMEGR 60
Query: 61 SQPLPSLRPASPTNAPAHGRGSDCTAKEPPLANVCRQNYGAAQDPVEPAGRRSASHVTGS 120
SQPLPSLRPASPTNAPAHGRGSDCTAKEPPLANVCRQNYGAAQDPVEPAGRRSASHVTGS
Sbjct: 61 SQPLPSLRPASPTNAPAHGRGSDCTAKEPPLANVCRQNYGAAQDPVEPAGRRSASHVTGS 120
Query: 121 SLGKAEVACGRRWRWAELLADTSWSPAGRATEMKVKMLSRNPDNYVRETKLDLQRVPRNY 180
SLGKAEVACGRRWRWAELLADTSWSPAGRATEMKVKMLSRNPDNYVRETKLDLQRVPRNY
Sbjct: 121 SLGKAEVACGRRWRWAELLADTSWSPAGRATEMKVKMLSRNPDNYVRETKLDLQRVPRNY 180
Query: 181 DPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACD 240
DPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACD
Sbjct: 181 DPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACD 240
Query: 241 GEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEE 300
GEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEE
Sbjct: 241 GEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEE 300
Query: 301 PLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIE 360
PLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIE
Sbjct: 301 PLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIE 360
Query: 361 TFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDM 420
TFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDM
Sbjct: 361 TFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDM 420
Query: 421 RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHV 480
RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHV
Sbjct: 421 RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHV 480
Query: 481 ICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIK 540
ICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIK
Sbjct: 481 ICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIK 540
Query: 541 RIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK 597
RIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK
Sbjct: 541 RIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK 597
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/338 (24%), Positives = 136/338 (40%), Gaps = 47/338 (13%)
Query: 192 EYIRALNATKLERVFAKPFLASLDGHRDGVN--CLAKHPEKLATVLSGACDGEVRIWNLT 249
E+I N T L R+ +P H D V C ++ +++A S D ++++
Sbjct: 596 EWINKKNITNLSRLVVRP-------HTDAVYHACFSEDGQRIA---SCGADKTLQVFKAE 645
Query: 250 QRNCIRTIQAHEGFVRGICTRFCGTSFF--TVGDDKTVKQWK-MDGP---GYGDEEEPLH 303
+ I+AHE V +C F F T DK VK W M G Y + E ++
Sbjct: 646 TGEKLLEIKAHEDEV--LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 703
Query: 304 TILGKTVYTGIDHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSISSVKFNPIET 361
+T HH + AT + +WD + +M +S++ +F+P +
Sbjct: 704 CCH----FTNSSHH---LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK 756
Query: 362 FLLGSCASDRNIVLYDMRQATPLKKVIL------------DMRTNTIC--WNPMEAFIFT 407
LL SC++D + L+D A K + + DM C W+ A I
Sbjct: 757 -LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 815
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSR 467
AA ++ FD+ +H H S + D+SP V A + ++ D SR
Sbjct: 816 AAKN--KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD-SR 872
Query: 468 SREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWK 505
S+ + V V ++ D + SD+ IRLW+
Sbjct: 873 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/62 (32%), Positives = 29/62 (46%)
Query: 230 KLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
K + +LS + DG V++WN+ N + H+G V T F + DKT K W
Sbjct: 1054 KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
Query: 290 MD 291
D
Sbjct: 1114 FD 1115
Score = 35.0 bits (79), Expect = 0.20
Identities = 17/83 (20%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 428 MVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTS 487
+V H AV +S G+ S DK++++F + + + + V+C +++
Sbjct: 609 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE-TGEKLLEIKAHEDEVLCCAFST 667
Query: 488 DSKYIMCGSDEMNIRLWKANASE 510
D ++I S + +++W + E
Sbjct: 668 DDRFIATCSVDKKVKIWNSMTGE 690
Score = 33.9 bits (76), Expect = 0.44
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 5/82 (6%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH--VICVKWTSDSK 490
H VL D S +F S S DK+ +I+ D H R + V C ++ DS
Sbjct: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP---LHELRGHNGCVRCSAFSVDST 1140
Query: 491 YIMCGSDEMNIRLWKANASEKL 512
+ G D IR+W + E L
Sbjct: 1141 LLATGDDNGEIRIWNVSNGELL 1162
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/338 (24%), Positives = 136/338 (40%), Gaps = 47/338 (13%)
Query: 192 EYIRALNATKLERVFAKPFLASLDGHRDGVN--CLAKHPEKLATVLSGACDGEVRIWNLT 249
E+I N T L R+ +P H D V C ++ +++A S D ++++
Sbjct: 585 EWINKKNITNLSRLVVRP-------HTDAVYHACFSEDGQRIA---SCGADKTLQVFKAE 634
Query: 250 QRNCIRTIQAHEGFVRGICTRFCGTSFF--TVGDDKTVKQWK-MDGP---GYGDEEEPLH 303
+ I+AHE V +C F F T DK VK W M G Y + E ++
Sbjct: 635 TGEKLLEIKAHEDEV--LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 692
Query: 304 TILGKTVYTGIDHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSISSVKFNPIET 361
+T HH + AT + +WD + +M +S++ +F+P +
Sbjct: 693 CCH----FTNSSHH---LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK 745
Query: 362 FLLGSCASDRNIVLYDMRQATPLKKVIL------------DMRTNTIC--WNPMEAFIFT 407
LL SC++D + L+D A K + + DM C W+ A I
Sbjct: 746 -LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 804
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSR 467
AA ++ FD+ +H H S + D+SP V A + ++ D SR
Sbjct: 805 AAKN--KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD-SR 861
Query: 468 SREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWK 505
S+ + V V ++ D + SD+ IRLW+
Sbjct: 862 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/62 (32%), Positives = 29/62 (46%)
Query: 230 KLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
K + +LS + DG V++WN+ N + H+G V T F + DKT K W
Sbjct: 1043 KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
Query: 290 MD 291
D
Sbjct: 1103 FD 1104
Score = 35.0 bits (79), Expect = 0.20
Identities = 17/83 (20%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 428 MVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTS 487
+V H AV +S G+ S DK++++F + + + + V+C +++
Sbjct: 598 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE-TGEKLLEIKAHEDEVLCCAFST 656
Query: 488 DSKYIMCGSDEMNIRLWKANASE 510
D ++I S + +++W + E
Sbjct: 657 DDRFIATCSVDKKVKIWNSMTGE 679
Score = 33.9 bits (76), Expect = 0.44
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 5/82 (6%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH--VICVKWTSDSK 490
H VL D S +F S S DK+ +I+ D H R + V C ++ DS
Sbjct: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP---LHELRGHNGCVRCSAFSVDST 1129
Query: 491 YIMCGSDEMNIRLWKANASEKL 512
+ G D IR+W + E L
Sbjct: 1130 LLATGDDNGEIRIWNVSNGELL 1151
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 65.9 bits (159), Expect = 1e-10
Identities = 69/304 (22%), Positives = 132/304 (43%), Gaps = 33/304 (10%)
Query: 221 VNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVG 280
V L+ HP++ +L+ +G +++W+ I H+G VRGI F + G
Sbjct: 12 VKGLSFHPKR-PWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGG 70
Query: 281 DDKTVKQWKMDGPGYGDEEEPLHTILGKTVY---TGIDHHWKEAVFATCGQQVDIWDEQR 337
DD +K W L T+LG Y T H + + A+ Q + +W+ Q
Sbjct: 71 DDYKIKVWNY------KLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
Query: 338 TNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTIC 397
+C +T + +F+P E L+ S + D+ + ++D I +R +
Sbjct: 125 RTCVCVLTGHNHYVMCAQFHPTED-LVVSASLDQTVRVWD----------ISGLRKKNLS 173
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFD 455
+E+ + + D+ V+ H+ H V + PT VS + D
Sbjct: 174 PGAVESDV-------RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADD 226
Query: 456 KSIRIFPVDKSRSREVYHTK-RMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGV 514
+ ++I+ +++S++ EV + +V C + + I+ S++ +IR+W + S++ GV
Sbjct: 227 RQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW--DMSKRTGV 284
Query: 515 LTSR 518
T R
Sbjct: 285 QTFR 288
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/201 (25%), Positives = 84/201 (41%), Gaps = 33/201 (16%)
Query: 211 LASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTR 270
L +L GH D + H E +LS + D +R+WN R C+ + H +V +C +
Sbjct: 86 LFTLLGHLDYIRTTFFHHE-YPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYV--MCAQ 142
Query: 271 FCGTSFFTVGD--DKTVKQWKMDG-----PGYGDEEEPLHTILG-----------KTVYT 312
F T V D+TV+ W + G G E + I G K V
Sbjct: 143 FHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLE 202
Query: 313 GIDHHWKEAVF---------ATCGQQVDIW--DEQRTNPICSMTWGFDSISSVKFNPIET 361
G D A F +QV IW +E + + + ++++S F+P +
Sbjct: 203 GHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQE 262
Query: 362 FLLGSCASDRNIVLYDMRQAT 382
+L S + D++I ++DM + T
Sbjct: 263 LIL-SNSEDKSIRVWDMSKRT 282
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 65.9 bits (159), Expect = 1e-10
Identities = 69/304 (22%), Positives = 132/304 (43%), Gaps = 33/304 (10%)
Query: 221 VNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVG 280
V L+ HP++ +L+ +G +++W+ I H+G VRGI F + G
Sbjct: 12 VKGLSFHPKR-PWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGG 70
Query: 281 DDKTVKQWKMDGPGYGDEEEPLHTILGKTVY---TGIDHHWKEAVFATCGQQVDIWDEQR 337
DD +K W L T+LG Y T H + + A+ Q + +W+ Q
Sbjct: 71 DDYKIKVWNY------KLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
Query: 338 TNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTIC 397
+C +T + +F+P E L+ S + D+ + ++D I +R +
Sbjct: 125 RTCVCVLTGHNHYVMCAQFHPTED-LVVSASLDQTVRVWD----------ISGLRKKNLS 173
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFD 455
+E+ + + D+ V+ H+ H V + PT VS + D
Sbjct: 174 PGAVESDV-------RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADD 226
Query: 456 KSIRIFPVDKSRSREVYHTK-RMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGV 514
+ ++I+ +++S++ EV + +V C + + I+ S++ +IR+W + S++ GV
Sbjct: 227 RQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW--DMSKRTGV 284
Query: 515 LTSR 518
T R
Sbjct: 285 QTFR 288
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/201 (25%), Positives = 84/201 (41%), Gaps = 33/201 (16%)
Query: 211 LASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTR 270
L +L GH D + H E +LS + D +R+WN R C+ + H +V +C +
Sbjct: 86 LFTLLGHLDYIRTTFFHHE-YPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYV--MCAQ 142
Query: 271 FCGTSFFTVGD--DKTVKQWKMDG-----PGYGDEEEPLHTILG-----------KTVYT 312
F T V D+TV+ W + G G E + I G K V
Sbjct: 143 FHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLE 202
Query: 313 GIDHHWKEAVF---------ATCGQQVDIW--DEQRTNPICSMTWGFDSISSVKFNPIET 361
G D A F +QV IW +E + + + ++++S F+P +
Sbjct: 203 GHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQE 262
Query: 362 FLLGSCASDRNIVLYDMRQAT 382
+L S + D++I ++DM + T
Sbjct: 263 LIL-SNSEDKSIRVWDMSKRT 282
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 65.5 bits (158), Expect = 1e-10
Identities = 87/329 (26%), Positives = 143/329 (43%), Gaps = 53/329 (16%)
Query: 213 SLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQR-----------NCIRTIQAHE 261
+L H DGV LA HP + V + D +++WNL + I T +AH
Sbjct: 475 TLRSHFDGVRALAFHPVEPVLVTASE-DHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHI 533
Query: 262 GFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYG--DEEEP---LHTILGKT------V 310
G V + G F+ G D T++ W M P D EP T++G T
Sbjct: 534 GPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLA 593
Query: 311 YTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDS----ISSVKFNPIETFLLGS 366
Y+GI + + + + V +W+ Q P C T+ D +SV F + + +
Sbjct: 594 YSGIKN---QLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPTSVDFIGCDPAHMVT 649
Query: 367 CASDRNIVLYDMRQATPLKKVILDMRT----------NTICWNPMEAFIFTAANEDYNLY 416
+ + V+YD+ + L VIL + N + +P T A+ED ++
Sbjct: 650 SFNTGSAVIYDLETSQSL--VILSSQVDSGLQSNNHINRVVSHPTLPVTIT-AHEDRHIK 706
Query: 417 TFDMRALDTPVMVH--MDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVD-KSRSREV-Y 472
FD + T M+H + H+ AV + P G +S S D SIR++ +D K+ +E+
Sbjct: 707 FFDNK---TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA 763
Query: 473 HTKRM-QHVICVKWTSDSKYI-MCGSDEM 499
H K++ + + V + S YI G+D +
Sbjct: 764 HRKKLDESIYDVAFHSSKAYIASAGADAL 792
Score = 32.7 bits (73), Expect = 0.97
Identities = 49/238 (20%), Positives = 102/238 (42%), Gaps = 35/238 (14%)
Query: 339 NPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKK-VILDMR----- 392
NP ++ FD + ++ F+P+E L+ + + D + L+++++ P KK LD+
Sbjct: 471 NPKYTLRSHFDGVRALAFHPVEPVLV-TASEDHTLKLWNLQKTVPAKKSASLDVEPIYTF 529
Query: 393 --------TNTICWNPMEAFI--FTAANEDYNLYTFDMRALDT--PVMVH---MDHVSAV 437
+ I N + F A + +N+ + + DT P ++ + H AV
Sbjct: 530 RAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAV 589
Query: 438 LDVDYSPTGKEFVSASFDKSIRIF-PVDKSRSREVYHTKRMQHV-ICVKWTS-DSKYIMC 494
+ YS + +S S D ++R++ P +K Y+ + + V + D +++
Sbjct: 590 WGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVT 649
Query: 495 GSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSI 552
+ + ++ S+ L +L+S+ + N HI R+ H LP +I
Sbjct: 650 SFNTGSAVIYDLETSQSLVILSSQVDSGLQSNN----------HINRVVSHPTLPVTI 697
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 65.5 bits (158), Expect = 1e-10
Identities = 87/329 (26%), Positives = 143/329 (43%), Gaps = 53/329 (16%)
Query: 213 SLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQR-----------NCIRTIQAHE 261
+L H DGV LA HP + V + D +++WNL + I T +AH
Sbjct: 391 TLRSHFDGVRALAFHPVEPVLVTASE-DHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHI 449
Query: 262 GFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYG--DEEEP---LHTILGKT------V 310
G V + G F+ G D T++ W M P D EP T++G T
Sbjct: 450 GPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLA 509
Query: 311 YTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDS----ISSVKFNPIETFLLGS 366
Y+GI + + + + V +W+ Q P C T+ D +SV F + + +
Sbjct: 510 YSGIKN---QLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHGIPTSVDFIGCDPAHMVT 565
Query: 367 CASDRNIVLYDMRQATPLKKVILDMRT----------NTICWNPMEAFIFTAANEDYNLY 416
+ + V+YD+ + L VIL + N + +P T A+ED ++
Sbjct: 566 SFNTGSAVIYDLETSQSL--VILSSQVDSGLQSNNHINRVVSHPTLPVTIT-AHEDRHIK 622
Query: 417 TFDMRALDTPVMVH--MDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVD-KSRSREV-Y 472
FD + T M+H + H+ AV + P G +S S D SIR++ +D K+ +E+
Sbjct: 623 FFDNK---TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA 679
Query: 473 HTKRM-QHVICVKWTSDSKYI-MCGSDEM 499
H K++ + + V + S YI G+D +
Sbjct: 680 HRKKLDESIYDVAFHSSKAYIASAGADAL 708
Score = 32.7 bits (73), Expect = 0.97
Identities = 49/238 (20%), Positives = 102/238 (42%), Gaps = 35/238 (14%)
Query: 339 NPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKK-VILDMR----- 392
NP ++ FD + ++ F+P+E L+ + + D + L+++++ P KK LD+
Sbjct: 387 NPKYTLRSHFDGVRALAFHPVEPVLV-TASEDHTLKLWNLQKTVPAKKSASLDVEPIYTF 445
Query: 393 --------TNTICWNPMEAFI--FTAANEDYNLYTFDMRALDT--PVMVH---MDHVSAV 437
+ I N + F A + +N+ + + DT P ++ + H AV
Sbjct: 446 RAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAV 505
Query: 438 LDVDYSPTGKEFVSASFDKSIRIF-PVDKSRSREVYHTKRMQHV-ICVKWTS-DSKYIMC 494
+ YS + +S S D ++R++ P +K Y+ + + V + D +++
Sbjct: 506 WGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVT 565
Query: 495 GSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSI 552
+ + ++ S+ L +L+S+ + N HI R+ H LP +I
Sbjct: 566 SFNTGSAVIYDLETSQSLVILSSQVDSGLQSNN----------HINRVVSHPTLPVTI 613
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/259 (20%), Positives = 103/259 (39%), Gaps = 13/259 (5%)
Query: 207 AKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRG 266
++ LA+L GH V + HP + V S + D +RIW++ +C++ ++AHE V G
Sbjct: 253 SEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTG 311
Query: 267 ICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVF--A 324
+ G + DD + W G + T H +F
Sbjct: 312 LSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG 368
Query: 325 TCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPL 384
T Q+ IWD + + + I+S+ F+ + L + A D ++ L+D+R+
Sbjct: 369 TMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE-NGYYLATAADDSSVKLWDLRKLKNF 427
Query: 385 KKVILD--MRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDY 442
K + LD ++ ++ ++ D +Y T ++ +H V +
Sbjct: 428 KTLQLDNNFEVKSLIFDQSGTYL-ALGGTDVQIYICKQW---TEILHFTEHSGLTTGVAF 483
Query: 443 SPTGKEFVSASFDKSIRIF 461
K S D+S++ +
Sbjct: 484 GHHAKFIASTGMDRSLKFY 502
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 63.2 bits (152), Expect = 7e-10
Identities = 75/298 (25%), Positives = 123/298 (41%), Gaps = 37/298 (12%)
Query: 213 SLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNL-----TQRNC------IRTIQAHE 261
+L H DG+ LA H + A +L+ + DG +++WNL ++N I +AH
Sbjct: 440 TLRSHYDGIRSLAFHHSQSA-LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHR 498
Query: 262 GFVRGICTRFCGTSFFTVGDDKTVKQWKMDG----PGYGDEEEPLHTIL---GKTVYTGI 314
G V + ++ G D + WK+ P G + L +L G V+ G+
Sbjct: 499 GPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW-GL 557
Query: 315 DHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSI----SSVKFNPIETFLLGSCA 368
A+C V IWD ++P C T+ S +SV F E + +
Sbjct: 558 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 617
Query: 369 SDRNIVLYDMRQATPLKKVILDMR-------TNTICWNPMEAFIFTAANEDYNLYTFDMR 421
+ VLYDM + L + L+ R N + +P + TA ++D + D R
Sbjct: 618 RSGDTVLYDMEVGSAL--LTLESRGSSGPTQINQVVSHPNQPLTITA-HDDRGIRFLDNR 674
Query: 422 ALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH 479
PV + H+ AV + P G +S S D S+R++ +D + R +H
Sbjct: 675 T-GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKH 731
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 63.2 bits (152), Expect = 7e-10
Identities = 75/298 (25%), Positives = 123/298 (41%), Gaps = 37/298 (12%)
Query: 213 SLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNL-----TQRNC------IRTIQAHE 261
+L H DG+ LA H + A +L+ + DG +++WNL ++N I +AH
Sbjct: 433 TLRSHYDGIRSLAFHHSQSA-LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHR 491
Query: 262 GFVRGICTRFCGTSFFTVGDDKTVKQWKMDG----PGYGDEEEPLHTIL---GKTVYTGI 314
G V + ++ G D + WK+ P G + L +L G V+ G+
Sbjct: 492 GPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW-GL 550
Query: 315 DHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSI----SSVKFNPIETFLLGSCA 368
A+C V IWD ++P C T+ S +SV F E + +
Sbjct: 551 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 610
Query: 369 SDRNIVLYDMRQATPLKKVILDMR-------TNTICWNPMEAFIFTAANEDYNLYTFDMR 421
+ VLYDM + L + L+ R N + +P + TA ++D + D R
Sbjct: 611 RSGDTVLYDMEVGSAL--LTLESRGSSGPTQINQVVSHPNQPLTITA-HDDRGIRFLDNR 667
Query: 422 ALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH 479
PV + H+ AV + P G +S S D S+R++ +D + R +H
Sbjct: 668 T-GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKH 724
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 61.6 bits (148), Expect = 2e-09
Identities = 75/298 (25%), Positives = 124/298 (41%), Gaps = 47/298 (15%)
Query: 192 EYIRALNATKLERVFAKPFLASLDGHRDGVN--CLAKHPEKLATVLSGACDGEVRIWNLT 249
E+I N T L R+ +P H D V C ++ +++A S D ++++
Sbjct: 596 EWINKKNITNLSRLVVRP-------HTDAVYHACFSEDGQRIA---SCGADKTLQVFKAE 645
Query: 250 QRNCIRTIQAHEGFVRGICTRFCGTSFF--TVGDDKTVKQWK-MDGP---GYGDEEEPLH 303
+ I+AHE V +C F F T DK VK W M G Y + E ++
Sbjct: 646 TGEKLLEIKAHEDEV--LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 703
Query: 304 TILGKTVYTGIDHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSISSVKFNPIET 361
+T HH + AT + +WD + +M +S++ +F+P +
Sbjct: 704 CCH----FTNSSHH---LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK 756
Query: 362 FLLGSCASDRNIVLYDMRQATPLKKVIL------------DMRTNTIC--WNPMEAFIFT 407
LL SC++D + L+D A K + + DM C W+ A I
Sbjct: 757 -LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 815
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDK 465
AA L+ D R+ H+ V V+ +SP G F+++S D++IR++ K
Sbjct: 816 AAKNKIFLWNTDSRSKVADCRGHLSWVHGVM---FSPDGSSFLTSSDDQTIRLWETKK 870
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/62 (32%), Positives = 29/62 (46%)
Query: 230 KLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
K + +LS + DG V++WN+ N + H+G V T F + DKT K W
Sbjct: 1011 KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1070
Query: 290 MD 291
D
Sbjct: 1071 FD 1072
Score = 35.0 bits (79), Expect = 0.20
Identities = 17/83 (20%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 428 MVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTS 487
+V H AV +S G+ S DK++++F + + + + V+C +++
Sbjct: 609 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE-TGEKLLEIKAHEDEVLCCAFST 667
Query: 488 DSKYIMCGSDEMNIRLWKANASE 510
D ++I S + +++W + E
Sbjct: 668 DDRFIATCSVDKKVKIWNSMTGE 690
Score = 33.9 bits (76), Expect = 0.44
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 5/82 (6%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH--VICVKWTSDSK 490
H VL D S +F S S DK+ +I+ D H R + V C ++ DS
Sbjct: 1041 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP---LHELRGHNGCVRCSAFSVDST 1097
Query: 491 YIMCGSDEMNIRLWKANASEKL 512
+ G D IR+W + E L
Sbjct: 1098 LLATGDDNGEIRIWNVSNGELL 1119
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 61.6 bits (148), Expect = 2e-09
Identities = 75/298 (25%), Positives = 124/298 (41%), Gaps = 47/298 (15%)
Query: 192 EYIRALNATKLERVFAKPFLASLDGHRDGVN--CLAKHPEKLATVLSGACDGEVRIWNLT 249
E+I N T L R+ +P H D V C ++ +++A S D ++++
Sbjct: 585 EWINKKNITNLSRLVVRP-------HTDAVYHACFSEDGQRIA---SCGADKTLQVFKAE 634
Query: 250 QRNCIRTIQAHEGFVRGICTRFCGTSFF--TVGDDKTVKQWK-MDGP---GYGDEEEPLH 303
+ I+AHE V +C F F T DK VK W M G Y + E ++
Sbjct: 635 TGEKLLEIKAHEDEV--LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 692
Query: 304 TILGKTVYTGIDHHWKEAVFATCGQQ--VDIWDEQRTNPICSMTWGFDSISSVKFNPIET 361
+T HH + AT + +WD + +M +S++ +F+P +
Sbjct: 693 CCH----FTNSSHH---LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK 745
Query: 362 FLLGSCASDRNIVLYDMRQATPLKKVIL------------DMRTNTIC--WNPMEAFIFT 407
LL SC++D + L+D A K + + DM C W+ A I
Sbjct: 746 -LLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 804
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDK 465
AA L+ D R+ H+ V V+ +SP G F+++S D++IR++ K
Sbjct: 805 AAKNKIFLWNTDSRSKVADCRGHLSWVHGVM---FSPDGSSFLTSSDDQTIRLWETKK 859
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/62 (32%), Positives = 29/62 (46%)
Query: 230 KLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
K + +LS + DG V++WN+ N + H+G V T F + DKT K W
Sbjct: 1000 KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1059
Query: 290 MD 291
D
Sbjct: 1060 FD 1061
Score = 35.0 bits (79), Expect = 0.20
Identities = 17/83 (20%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 428 MVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTS 487
+V H AV +S G+ S DK++++F + + + + V+C +++
Sbjct: 598 LVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE-TGEKLLEIKAHEDEVLCCAFST 656
Query: 488 DSKYIMCGSDEMNIRLWKANASE 510
D ++I S + +++W + E
Sbjct: 657 DDRFIATCSVDKKVKIWNSMTGE 679
Score = 33.9 bits (76), Expect = 0.44
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 5/82 (6%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH--VICVKWTSDSK 490
H VL D S +F S S DK+ +I+ D H R + V C ++ DS
Sbjct: 1030 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP---LHELRGHNGCVRCSAFSVDST 1086
Query: 491 YIMCGSDEMNIRLWKANASEKL 512
+ G D IR+W + E L
Sbjct: 1087 LLATGDDNGEIRIWNVSNGELL 1108
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.2 bits (147), Expect = 3e-09
Identities = 63/265 (23%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 211 LASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTR 270
+ SLD + DG + G+ DG RIW N T+ H+G + +
Sbjct: 238 VTSLDWNSDGT-----------LLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWN 285
Query: 271 FCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAV-FATCGQQ 329
G + G DKT W G ++ P H+ +D W+ + FA+C
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAH-TGEAKQQFPFHSA------PALDVDWQNNMTFASCSTD 338
Query: 330 --VDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKV 387
+ + +P+ + + ++++K++P LL SC+ D + ++ M+Q + +
Sbjct: 339 MCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDL 397
Query: 388 ILDMRT-NTICW--------NPMEAFIFTAANEDYNLYTFDMRALDTPVMVH--MDHVSA 436
+ TI W NP + + +A+ D + +D+ + V H M H
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV---EQGVCTHTLMKHQEP 454
Query: 437 VLDVDYSPTGKEFVSASFDKSIRIF 461
V V +SP GK S SFDK + I+
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 52.4 bits (124), Expect = 1e-06
Identities = 75/334 (22%), Positives = 117/334 (35%), Gaps = 64/334 (19%)
Query: 214 LDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFC- 272
L GH V A +P + SG+ D RIWNL + + G + R C
Sbjct: 175 LRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENS--------NGGSTQLVLRHCI 225
Query: 273 --GTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEA--VFATCGQ 328
G D T W DG T+L Y G W E + +T GQ
Sbjct: 226 REGGHDVPSNKDVTSLDWNSDG-----------TLLAMGSYDGFARIWTENGNLASTLGQ 274
Query: 329 Q--------------------VD----IWDEQRTNPICSMTWGFDSISSVKFNPIETFLL 364
VD IWD + F S ++ +
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE--AKQQFPFHSAPALDVDWQNNMTF 332
Query: 365 GSCASDRNIVLYDMRQATPLKKVILDMR-TNTICWNPMEAFIFTAANEDYNLYTFDMRAL 423
SC++D I + + P+K N I W+P + + ++D L + M+
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQ- 390
Query: 424 DTPVMVHMDHVSAVLDVDYSPTGKE---------FVSASFDKSIRIFPVDKSRSREVYHT 474
D V H + + +SPTG SASFD ++R++ V++
Sbjct: 391 DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL-M 449
Query: 475 KRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANA 508
K + V V ++ D KY+ GS + + +W +
Sbjct: 450 KHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.2 bits (147), Expect = 3e-09
Identities = 63/265 (23%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 211 LASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTR 270
+ SLD + DG + G+ DG RIW N T+ H+G + +
Sbjct: 238 VTSLDWNSDGT-----------LLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWN 285
Query: 271 FCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAV-FATCGQQ 329
G + G DKT W G ++ P H+ +D W+ + FA+C
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAH-TGEAKQQFPFHSA------PALDVDWQNNMTFASCSTD 338
Query: 330 --VDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKV 387
+ + +P+ + + ++++K++P LL SC+ D + ++ M+Q + +
Sbjct: 339 MCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDL 397
Query: 388 ILDMRT-NTICW--------NPMEAFIFTAANEDYNLYTFDMRALDTPVMVH--MDHVSA 436
+ TI W NP + + +A+ D + +D+ + V H M H
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV---EQGVCTHTLMKHQEP 454
Query: 437 VLDVDYSPTGKEFVSASFDKSIRIF 461
V V +SP GK S SFDK + I+
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 52.4 bits (124), Expect = 1e-06
Identities = 75/334 (22%), Positives = 117/334 (35%), Gaps = 64/334 (19%)
Query: 214 LDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFC- 272
L GH V A +P + SG+ D RIWNL + + G + R C
Sbjct: 175 LRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENS--------NGGSTQLVLRHCI 225
Query: 273 --GTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEA--VFATCGQ 328
G D T W DG T+L Y G W E + +T GQ
Sbjct: 226 REGGHDVPSNKDVTSLDWNSDG-----------TLLAMGSYDGFARIWTENGNLASTLGQ 274
Query: 329 Q--------------------VD----IWDEQRTNPICSMTWGFDSISSVKFNPIETFLL 364
VD IWD + F S ++ +
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE--AKQQFPFHSAPALDVDWQNNMTF 332
Query: 365 GSCASDRNIVLYDMRQATPLKKVILDMR-TNTICWNPMEAFIFTAANEDYNLYTFDMRAL 423
SC++D I + + P+K N I W+P + + ++D L + M+
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQ- 390
Query: 424 DTPVMVHMDHVSAVLDVDYSPTGKE---------FVSASFDKSIRIFPVDKSRSREVYHT 474
D V H + + +SPTG SASFD ++R++ V++
Sbjct: 391 DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL-M 449
Query: 475 KRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANA 508
K + V V ++ D KY+ GS + + +W +
Sbjct: 450 KHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.2 bits (147), Expect = 3e-09
Identities = 63/265 (23%), Positives = 110/265 (41%), Gaps = 37/265 (13%)
Query: 211 LASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTR 270
+ SLD + DG + G+ DG RIW N T+ H+G + +
Sbjct: 238 VTSLDWNSDGT-----------LLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWN 285
Query: 271 FCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAV-FATCGQQ 329
G + G DKT W G ++ P H+ +D W+ + FA+C
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAH-TGEAKQQFPFHSA------PALDVDWQNNMTFASCSTD 338
Query: 330 --VDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKV 387
+ + +P+ + + ++++K++P LL SC+ D + ++ M+Q + +
Sbjct: 339 MCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDL 397
Query: 388 ILDMRT-NTICW--------NPMEAFIFTAANEDYNLYTFDMRALDTPVMVH--MDHVSA 436
+ TI W NP + + +A+ D + +D+ + V H M H
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV---EQGVCTHTLMKHQEP 454
Query: 437 VLDVDYSPTGKEFVSASFDKSIRIF 461
V V +SP GK S SFDK + I+
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 52.4 bits (124), Expect = 1e-06
Identities = 75/334 (22%), Positives = 117/334 (35%), Gaps = 64/334 (19%)
Query: 214 LDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFC- 272
L GH V A +P + SG+ D RIWNL + + G + R C
Sbjct: 175 LRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENS--------NGGSTQLVLRHCI 225
Query: 273 --GTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEA--VFATCGQ 328
G D T W DG T+L Y G W E + +T GQ
Sbjct: 226 REGGHDVPSNKDVTSLDWNSDG-----------TLLAMGSYDGFARIWTENGNLASTLGQ 274
Query: 329 Q--------------------VD----IWDEQRTNPICSMTWGFDSISSVKFNPIETFLL 364
VD IWD + F S ++ +
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE--AKQQFPFHSAPALDVDWQNNMTF 332
Query: 365 GSCASDRNIVLYDMRQATPLKKVILDMR-TNTICWNPMEAFIFTAANEDYNLYTFDMRAL 423
SC++D I + + P+K N I W+P + + ++D L + M+
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQ- 390
Query: 424 DTPVMVHMDHVSAVLDVDYSPTGKE---------FVSASFDKSIRIFPVDKSRSREVYHT 474
D V H + + +SPTG SASFD ++R++ V++
Sbjct: 391 DACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL-M 449
Query: 475 KRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANA 508
K + V V ++ D KY+ GS + + +W +
Sbjct: 450 KHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 60.8 bits (146), Expect = 3e-09
Identities = 65/260 (25%), Positives = 107/260 (41%), Gaps = 34/260 (13%)
Query: 216 GHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFC--G 273
GH+D V C+ P + SG+ D VRIW + +AH VR + FC G
Sbjct: 21 GHKDAVTCVNFSPSG-HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV--HFCSDG 77
Query: 274 TSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDH-HW----------KEAV 322
SF T DDKTVK W T K +++ H +W + V
Sbjct: 78 QSFVTASDDKTVKVWA--------------THRQKFLFSLSQHINWVRCAKFSPDGRLIV 123
Query: 323 FATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQAT 382
A+ + V +WD+ + S ++ V F+P T + + D + ++D+R
Sbjct: 124 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHR 182
Query: 383 PLKKVIL-DMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVD 441
L+ L N + ++P ++ TA++ D L D+ +H H V
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASS-DSTLKILDLMEGRLLYTLH-GHQGPATTVA 240
Query: 442 YSPTGKEFVSASFDKSIRIF 461
+S TG+ F S D+ + ++
Sbjct: 241 FSRTGEYFASGGSDEQVMVW 260
Score = 47.0 bits (110), Expect = 5e-05
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 210 FLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICT 269
FL SL H + V C P+ ++S + D V++W+ + R C+ + H GFV +
Sbjct: 99 FLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 157
Query: 270 RFCGTSFFTVGDDKTVKQW 288
GT G D TVK W
Sbjct: 158 HPSGTCIAAAGMDNTVKVW 176
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 7/81 (8%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH---VICVKWTSDS 489
H + V V + G+ FV+AS DK+++++ + R+ + QH V C K++ D
Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVW----ATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 490 KYIMCGSDEMNIRLWKANASE 510
+ I+ SD+ ++LW ++ E
Sbjct: 120 RLIVSASDDKTVKLWDKSSRE 140
Score = 37.7 bits (86), Expect = 0.030
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYI 492
H AV V++SP+G S S DK++RI+ V + V V + SD +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 493 MCGSDEMNIRLWKANASEKL 512
+ SD+ +++W + + L
Sbjct: 81 VTASDDKTVKVWATHRQKFL 100
Score = 33.9 bits (76), Expect = 0.44
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 1/92 (1%)
Query: 198 NATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTI 257
N K+ V L H VN L+ HP +++ + D ++I +L + + T+
Sbjct: 171 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-NYLITASSDSTLKILDLMEGRLLYTL 229
Query: 258 QAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
H+G + G F + G D+ V WK
Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 60.8 bits (146), Expect = 3e-09
Identities = 58/244 (23%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 236 SGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGY 295
+G+ DG RIW N T+ H+G + + G + G DKT W G
Sbjct: 242 TGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAH-TGE 299
Query: 296 GDEEEPLHTILGKTVYTGIDHHWKEA-VFATCGQQ--VDIWDEQRTNPICSMTWGFDSIS 352
++ P H+ +D W+ FA+C + + + PI + + ++
Sbjct: 300 AKQQFPFHSA------PALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVN 353
Query: 353 SVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTN-----TICW--------N 399
++K++P LL SC+ D + ++ M+Q + D++ + TI W N
Sbjct: 354 AIKWDPTGN-LLASCSDDMTLKIWSMKQ----DNCVHDLQAHNKEIYTIKWSPTGPGTNN 408
Query: 400 PMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFDKS 457
P + +A+ D + +D+ D + +H H V V +SP G+ S SFDK
Sbjct: 409 PNANLMLASASFDSTVRLWDV---DRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
Query: 458 IRIF 461
+ I+
Sbjct: 466 VHIW 469
Score = 53.5 bits (127), Expect = 5e-07
Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 58/327 (17%)
Query: 214 LDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCG 273
L GH V A +P + SG+ D RIWNL++ + + Q V C R G
Sbjct: 165 LRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQ----LVLRHCIREGG 219
Query: 274 TSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEA--VFATCGQQ-- 329
+ D T W +G T+L Y G W + + +T GQ
Sbjct: 220 QDVPS-NKDVTSLDWNSEG-----------TLLATGSYDGFARIWTKDGNLASTLGQHKG 267
Query: 330 ------------------VD----IWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSC 367
VD IWD + F S ++ + SC
Sbjct: 268 PIFALKWNKKGNFILSAGVDKTTIIWDAHTGE--AKQQFPFHSAPALDVDWQSNNTFASC 325
Query: 368 ASDRNIVLYDMRQATPLKKVILDMR-TNTICWNPMEAFIFTAANEDYNLYTFDMRALDTP 426
++D I + + Q P+K N I W+P + + ++D L + M+ D
Sbjct: 326 STDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMKQ-DNC 383
Query: 427 VMVHMDHVSAVLDVDYSPTGKE---------FVSASFDKSIRIFPVDKSRSREVYHTKRM 477
V H + + +SPTG SASFD ++R++ VD+ TK
Sbjct: 384 VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTL-TKHQ 442
Query: 478 QHVICVKWTSDSKYIMCGSDEMNIRLW 504
+ V V ++ D +Y+ GS + + +W
Sbjct: 443 EPVYSVAFSPDGRYLASGSFDKCVHIW 469
Score = 35.4 bits (80), Expect = 0.15
Identities = 42/195 (21%), Positives = 78/195 (40%), Gaps = 8/195 (4%)
Query: 233 TVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDG 292
T S + D + + L Q I+T Q H V I G + DD T+K W M
Sbjct: 321 TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ 380
Query: 293 PGYGDE----EEPLHTILGKTVYTGIDHHWKEAVFATCG--QQVDIWDEQRTNPICSMTW 346
+ + ++TI G ++ + A+ V +WD R I ++T
Sbjct: 381 DNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTK 440
Query: 347 GFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIF 406
+ + SV F+P + L S + D+ + +++ + + +CWN +
Sbjct: 441 HQEPVYSVAFSPDGRY-LASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVG 499
Query: 407 TAANEDYNLYTFDMR 421
+A+ D ++ D+R
Sbjct: 500 ASAS-DGSVCVLDLR 513
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 60.5 bits (145), Expect = 4e-09
Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 236 SGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGY 295
+G+ DG RIW N T+ H+G + + G + G DKT W G
Sbjct: 254 TGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAH-TGE 311
Query: 296 GDEEEPLHTILGKTVYTGIDHHWKE-AVFATCGQQ--VDIWDEQRTNPICSMTWGFDSIS 352
++ P H+ +D W+ FA+C + + P+ + + ++
Sbjct: 312 AKQQFPFHSA------PALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVN 365
Query: 353 SVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVIL-DMRTNTICW--------NPMEA 403
++K++P LL SC+ D + ++ M+Q + + + TI W NP
Sbjct: 366 AIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN 424
Query: 404 FIFTAANEDYNLYTFDM-RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFP 462
+ +A+ D + +D+ R + T + H V V +SP GK S SFDK + I+
Sbjct: 425 IMLASASFDSTVRLWDIERGVCTHTLTK--HQEPVYSVAFSPDGKYLASGSFDKCVHIW- 481
Query: 463 VDKSRSREVYHTKR 476
++S + H+ R
Sbjct: 482 --NTQSGNLVHSYR 493
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 60.5 bits (145), Expect = 4e-09
Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 236 SGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGY 295
+G+ DG RIW N T+ H+G + + G + G DKT W G
Sbjct: 254 TGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAH-TGE 311
Query: 296 GDEEEPLHTILGKTVYTGIDHHWKE-AVFATCGQQ--VDIWDEQRTNPICSMTWGFDSIS 352
++ P H+ +D W+ FA+C + + P+ + + ++
Sbjct: 312 AKQQFPFHSA------PALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVN 365
Query: 353 SVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVIL-DMRTNTICW--------NPMEA 403
++K++P LL SC+ D + ++ M+Q + + + TI W NP
Sbjct: 366 AIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN 424
Query: 404 FIFTAANEDYNLYTFDM-RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFP 462
+ +A+ D + +D+ R + T + H V V +SP GK S SFDK + I+
Sbjct: 425 IMLASASFDSTVRLWDIERGVCTHTLTK--HQEPVYSVAFSPDGKYLASGSFDKCVHIW- 481
Query: 463 VDKSRSREVYHTKR 476
++S + H+ R
Sbjct: 482 --NTQSGNLVHSYR 493
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 60.5 bits (145), Expect = 4e-09
Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 236 SGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGY 295
+G+ DG RIW N T+ H+G + + G + G DKT W G
Sbjct: 305 TGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAH-TGE 362
Query: 296 GDEEEPLHTILGKTVYTGIDHHWKE-AVFATCGQQ--VDIWDEQRTNPICSMTWGFDSIS 352
++ P H+ +D W+ FA+C + + P+ + + ++
Sbjct: 363 AKQQFPFHSA------PALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVN 416
Query: 353 SVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVIL-DMRTNTICW--------NPMEA 403
++K++P LL SC+ D + ++ M+Q + + + TI W NP
Sbjct: 417 AIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN 475
Query: 404 FIFTAANEDYNLYTFDM-RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFP 462
+ +A+ D + +D+ R + T + H V V +SP GK S SFDK + I+
Sbjct: 476 IMLASASFDSTVRLWDIERGVCTHTLTK--HQEPVYSVAFSPDGKYLASGSFDKCVHIW- 532
Query: 463 VDKSRSREVYHTKR 476
++S + H+ R
Sbjct: 533 --NTQSGNLVHSYR 544
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 60.5 bits (145), Expect = 4e-09
Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 236 SGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGY 295
+G+ DG RIW N T+ H+G + + G + G DKT W G
Sbjct: 305 TGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAH-TGE 362
Query: 296 GDEEEPLHTILGKTVYTGIDHHWKE-AVFATCGQQ--VDIWDEQRTNPICSMTWGFDSIS 352
++ P H+ +D W+ FA+C + + P+ + + ++
Sbjct: 363 AKQQFPFHSA------PALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVN 416
Query: 353 SVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVIL-DMRTNTICW--------NPMEA 403
++K++P LL SC+ D + ++ M+Q + + + TI W NP
Sbjct: 417 AIKWDP-SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN 475
Query: 404 FIFTAANEDYNLYTFDM-RALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFP 462
+ +A+ D + +D+ R + T + H V V +SP GK S SFDK + I+
Sbjct: 476 IMLASASFDSTVRLWDIERGVCTHTLTK--HQEPVYSVAFSPDGKYLASGSFDKCVHIW- 532
Query: 463 VDKSRSREVYHTKR 476
++S + H+ R
Sbjct: 533 --NTQSGNLVHSYR 544
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 59.3 bits (142), Expect = 1e-08
Identities = 67/304 (22%), Positives = 119/304 (39%), Gaps = 69/304 (22%)
Query: 216 GHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLT-QRNCIRTIQAHEGFVRGICTRFCGT 274
GH GV+ + P +LS + D ++++W + +R C+RT H VR IC GT
Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
Query: 275 SFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWD 334
F + D+ +K W + GQ + +
Sbjct: 346 QFLSAAYDRYLKLWDTE----------------------------------TGQCISRFT 371
Query: 335 EQRTNPICSMTWGFDSISSVKFNPIE----TFLLGSCASDRNIVLYDMRQATPLKKVILD 390
++ P C VKFNP E F+ G SD+ IV +D+R +++
Sbjct: 372 NRKV-PYC-----------VKFNPDEDKQNLFVAG--MSDKKIVQWDIRSGEIVQEYDRH 417
Query: 391 M-RTNTICW-NPMEAFIFTAANEDYNLYTFDM----RALDTPVMVHMDHVSAVLDVDYSP 444
+ NTI + + F+ T+ ++ ++ +D+ + + P M M V+ SP
Sbjct: 418 LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVT------LSP 471
Query: 445 TGKEFVSASFDKSIRIFPVD---KSRSREVYHTKRMQHVIC-VKWTSDSKYIMCGSDEMN 500
GK S D I IF + ++++ + C V ++ D Y++ G
Sbjct: 472 NGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGK 531
Query: 501 IRLW 504
+ +W
Sbjct: 532 LNIW 535
Score = 40.8 bits (94), Expect = 0.004
Identities = 38/159 (23%), Positives = 70/159 (44%), Gaps = 4/159 (2%)
Query: 350 SISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPME--AFIFT 407
++ + FN T L S A DR + L+D + + + +NP E +F
Sbjct: 334 AVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV 392
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSR 467
A D + +D+R+ + V + H+ AV + + + FVS S DKS+R++ D
Sbjct: 393 AGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPV 451
Query: 468 SREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKA 506
+ M + V + + K++ C S + I ++ A
Sbjct: 452 DFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGA 490
Score = 36.2 bits (82), Expect = 0.088
Identities = 19/114 (16%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 400 PMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIR 459
P+ + + + D + +++ + + H AV D+ ++ G +F+SA++D+ ++
Sbjct: 298 PLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLK 357
Query: 460 IFPVDKSRSREVYHTKRMQHVICVKWTSD---SKYIMCGSDEMNIRLWKANASE 510
++ + + + +++ + CVK+ D + G + I W + E
Sbjct: 358 LWDTETGQCISRFTNRKVPY--CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE 409
>gi|5902034 periodic tryptophan protein 1 [Homo sapiens]
Length = 501
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/185 (24%), Positives = 81/185 (43%), Gaps = 5/185 (2%)
Query: 324 ATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATP 383
A+ V +WD P S+ D + +++F+P E L S + D+++ LYD R
Sbjct: 275 ASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPDE 334
Query: 384 LKKV-ILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDY 442
++ + + WN F A+ +D +Y D R+ D P+ H + +D
Sbjct: 335 SHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS-DKPIFTLNAHNDEISGLDL 393
Query: 443 SPTGKE-FVSASFDKSIRIFPVDKSRSREVY-HTKRMQHVICVKWTSDSKYIMC-GSDEM 499
S K V+AS DK ++I+ + R V+ +M + C D +I G +
Sbjct: 394 SSQIKGCLVTASADKYVKIWDILGDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKE 453
Query: 500 NIRLW 504
+R+W
Sbjct: 454 GLRVW 458
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.2 bits (139), Expect = 2e-08
Identities = 64/303 (21%), Positives = 127/303 (41%), Gaps = 29/303 (9%)
Query: 216 GHRDGVNCL--AKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCG 273
GHRD V C+ + + ++LA SG+ D + +W++ ++ H+ V + G
Sbjct: 17 GHRDAVTCVDFSINTKQLA---SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 274 TSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIW 333
+ DKTV+ W + G HT ++V+ D + V A+ + V +W
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDG--QSFVTASDDKTVKVW 130
Query: 334 DEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKK------- 386
R + S++ + + KF+P + L+ S + D+ + L+D +
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 387 -VILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMD-HVSAVLDVDYSP 444
+D + C AA D + +D+R ++ H H +AV + + P
Sbjct: 190 VTYVDFHPSGTC--------IAAAGMDNTVKVWDVRT--HRLLQHYQLHSAAVNGLSFHP 239
Query: 445 TGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLW 504
+G ++AS D +++I + + R H + V ++ +Y G + + +W
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP-ATTVAFSRTGEYFASGGSDEQVMVW 298
Query: 505 KAN 507
K+N
Sbjct: 299 KSN 301
Score = 47.0 bits (110), Expect = 5e-05
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 210 FLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICT 269
FL SL H + V C P+ ++S + D V++W+ + R C+ + H GFV +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195
Query: 270 RFCGTSFFTVGDDKTVKQW 288
GT G D TVK W
Sbjct: 196 HPSGTCIAAAGMDNTVKVW 214
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 7/81 (8%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH---VICVKWTSDS 489
H + V V + G+ FV+AS DK+++++ + R+ + QH V C K++ D
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVW----ATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 490 KYIMCGSDEMNIRLWKANASE 510
+ I+ SD+ ++LW ++ E
Sbjct: 158 RLIVSASDDKTVKLWDKSSRE 178
Score = 37.7 bits (86), Expect = 0.030
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYI 492
H AV V++SP+G S S DK++RI+ V + V V + SD +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 493 MCGSDEMNIRLWKANASEKL 512
+ SD+ +++W + + L
Sbjct: 119 VTASDDKTVKVWATHRQKFL 138
Score = 33.9 bits (76), Expect = 0.44
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 1/92 (1%)
Query: 198 NATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTI 257
N K+ V L H VN L+ HP +++ + D ++I +L + + T+
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-NYLITASSDSTLKILDLMEGRLLYTL 267
Query: 258 QAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
H+G + G F + G D+ V WK
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.2 bits (139), Expect = 2e-08
Identities = 64/303 (21%), Positives = 127/303 (41%), Gaps = 29/303 (9%)
Query: 216 GHRDGVNCL--AKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCG 273
GHRD V C+ + + ++LA SG+ D + +W++ ++ H+ V + G
Sbjct: 17 GHRDAVTCVDFSINTKQLA---SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 274 TSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIW 333
+ DKTV+ W + G HT ++V+ D + V A+ + V +W
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDG--QSFVTASDDKTVKVW 130
Query: 334 DEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKK------- 386
R + S++ + + KF+P + L+ S + D+ + L+D +
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 387 -VILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMD-HVSAVLDVDYSP 444
+D + C AA D + +D+R ++ H H +AV + + P
Sbjct: 190 VTYVDFHPSGTC--------IAAAGMDNTVKVWDVRT--HRLLQHYQLHSAAVNGLSFHP 239
Query: 445 TGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLW 504
+G ++AS D +++I + + R H + V ++ +Y G + + +W
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP-ATTVAFSRTGEYFASGGSDEQVMVW 298
Query: 505 KAN 507
K+N
Sbjct: 299 KSN 301
Score = 47.0 bits (110), Expect = 5e-05
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 210 FLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICT 269
FL SL H + V C P+ ++S + D V++W+ + R C+ + H GFV +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDG-RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195
Query: 270 RFCGTSFFTVGDDKTVKQW 288
GT G D TVK W
Sbjct: 196 HPSGTCIAAAGMDNTVKVW 214
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 7/81 (8%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQH---VICVKWTSDS 489
H + V V + G+ FV+AS DK+++++ + R+ + QH V C K++ D
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVW----ATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 490 KYIMCGSDEMNIRLWKANASE 510
+ I+ SD+ ++LW ++ E
Sbjct: 158 RLIVSASDDKTVKLWDKSSRE 178
Score = 37.7 bits (86), Expect = 0.030
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Query: 433 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYI 492
H AV V++SP+G S S DK++RI+ V + V V + SD +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 493 MCGSDEMNIRLWKANASEKL 512
+ SD+ +++W + + L
Sbjct: 119 VTASDDKTVKVWATHRQKFL 138
Score = 33.9 bits (76), Expect = 0.44
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 1/92 (1%)
Query: 198 NATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTI 257
N K+ V L H VN L+ HP +++ + D ++I +L + + T+
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-NYLITASSDSTLKILDLMEGRLLYTL 267
Query: 258 QAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 289
H+G + G F + G D+ V WK
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 56.6 bits (135), Expect = 6e-08
Identities = 38/145 (26%), Positives = 75/145 (51%), Gaps = 10/145 (6%)
Query: 169 TKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKP---FLASLDGHRDGVNCLA 225
T + L+RV + A++ + +YI + + + +V++ F+ +L+GH+ G+ CL
Sbjct: 351 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL- 409
Query: 226 KHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTV 285
++ ++L V+SG+ D +R+W++ C+R ++ HE VR C RF + D +
Sbjct: 410 QYRDRL--VVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKI 465
Query: 286 KQWKMDGPGYGDEEEPLHTILGKTV 310
K W + D P T+ +T+
Sbjct: 466 KVWDLQAA--LDPRAPASTLCLRTL 488
Score = 53.1 bits (126), Expect = 7e-07
Identities = 62/294 (21%), Positives = 122/294 (41%), Gaps = 66/294 (22%)
Query: 220 GVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTV 279
GV CL EK ++SG D ++IW+ T C++ + H G V +C ++ T
Sbjct: 242 GVYCLQYDDEK---IISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTG 296
Query: 280 GDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN 339
D TV+ W ++ G+ + T I H+
Sbjct: 297 SSDSTVRVWDVN--------------TGEVLNTLIHHN---------------------- 320
Query: 340 PICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQAT--PLKKVILDMRTNTIC 397
+++ ++F+ L+ +C+ DR+I ++DM AT L++V++ R
Sbjct: 321 ---------EAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 368
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFD 455
+ + +I +A+ + T + + T V H + + Y + VS S D
Sbjct: 369 VDFDDKYIVSASGD----RTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSD 422
Query: 456 KSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANAS 509
+IR++ ++ V + V C+++ D+K I+ G+ + I++W A+
Sbjct: 423 NTIRLWDIECGACLRVLEGHE-ELVRCIRF--DNKRIVSGAYDGKIKVWDLQAA 473
Score = 29.6 bits (65), Expect = 8.2
Identities = 35/167 (20%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 370 DRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDT-PVM 428
D +I ++D LK +L T ++ + + + D + +D+ + +
Sbjct: 259 DNSIKIWDKTSLECLK--VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 316
Query: 429 VHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPV----DKSRSREVYHTKRMQHVICVK 484
+H H AVL + +S V+ S D+SI ++ + D + R + + +V+
Sbjct: 317 IH--HNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV--- 369
Query: 485 WTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREK--AAKDYNQKL 529
D KYI+ S + I++W + E + L ++ A Y +L
Sbjct: 370 -DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL 415
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 56.6 bits (135), Expect = 6e-08
Identities = 38/145 (26%), Positives = 75/145 (51%), Gaps = 10/145 (6%)
Query: 169 TKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKP---FLASLDGHRDGVNCLA 225
T + L+RV + A++ + +YI + + + +V++ F+ +L+GH+ G+ CL
Sbjct: 317 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL- 375
Query: 226 KHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTV 285
++ ++L V+SG+ D +R+W++ C+R ++ HE VR C RF + D +
Sbjct: 376 QYRDRL--VVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKI 431
Query: 286 KQWKMDGPGYGDEEEPLHTILGKTV 310
K W + D P T+ +T+
Sbjct: 432 KVWDLQAA--LDPRAPASTLCLRTL 454
Score = 53.1 bits (126), Expect = 7e-07
Identities = 62/294 (21%), Positives = 122/294 (41%), Gaps = 66/294 (22%)
Query: 220 GVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTV 279
GV CL EK ++SG D ++IW+ T C++ + H G V +C ++ T
Sbjct: 208 GVYCLQYDDEK---IISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTG 262
Query: 280 GDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN 339
D TV+ W ++ G+ + T I H+
Sbjct: 263 SSDSTVRVWDVN--------------TGEVLNTLIHHN---------------------- 286
Query: 340 PICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQAT--PLKKVILDMRTNTIC 397
+++ ++F+ L+ +C+ DR+I ++DM AT L++V++ R
Sbjct: 287 ---------EAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFD 455
+ + +I +A+ + T + + T V H + + Y + VS S D
Sbjct: 335 VDFDDKYIVSASGD----RTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSD 388
Query: 456 KSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANAS 509
+IR++ ++ V + V C+++ D+K I+ G+ + I++W A+
Sbjct: 389 NTIRLWDIECGACLRVLEGHE-ELVRCIRF--DNKRIVSGAYDGKIKVWDLQAA 439
Score = 29.6 bits (65), Expect = 8.2
Identities = 35/167 (20%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 370 DRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDT-PVM 428
D +I ++D LK +L T ++ + + + D + +D+ + +
Sbjct: 225 DNSIKIWDKTSLECLK--VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282
Query: 429 VHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPV----DKSRSREVYHTKRMQHVICVK 484
+H H AVL + +S V+ S D+SI ++ + D + R + + +V+
Sbjct: 283 IH--HNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV--- 335
Query: 485 WTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREK--AAKDYNQKL 529
D KYI+ S + I++W + E + L ++ A Y +L
Sbjct: 336 -DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL 381
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 56.6 bits (135), Expect = 6e-08
Identities = 38/145 (26%), Positives = 75/145 (51%), Gaps = 10/145 (6%)
Query: 169 TKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKP---FLASLDGHRDGVNCLA 225
T + L+RV + A++ + +YI + + + +V++ F+ +L+GH+ G+ CL
Sbjct: 338 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL- 396
Query: 226 KHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTV 285
++ ++L V+SG+ D +R+W++ C+R ++ HE VR C RF + D +
Sbjct: 397 QYRDRL--VVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKI 452
Query: 286 KQWKMDGPGYGDEEEPLHTILGKTV 310
K W + D P T+ +T+
Sbjct: 453 KVWDLQAA--LDPRAPASTLCLRTL 475
Score = 53.1 bits (126), Expect = 7e-07
Identities = 62/294 (21%), Positives = 122/294 (41%), Gaps = 66/294 (22%)
Query: 220 GVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTV 279
GV CL EK ++SG D ++IW+ T C++ + H G V +C ++ T
Sbjct: 229 GVYCLQYDDEK---IISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQYDERVIVTG 283
Query: 280 GDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN 339
D TV+ W ++ G+ + T I H+
Sbjct: 284 SSDSTVRVWDVN--------------TGEVLNTLIHHN---------------------- 307
Query: 340 PICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQAT--PLKKVILDMRTNTIC 397
+++ ++F+ L+ +C+ DR+I ++DM AT L++V++ R
Sbjct: 308 ---------EAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFD 455
+ + +I +A+ + T + + T V H + + Y + VS S D
Sbjct: 356 VDFDDKYIVSASGD----RTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSD 409
Query: 456 KSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANAS 509
+IR++ ++ V + V C+++ D+K I+ G+ + I++W A+
Sbjct: 410 NTIRLWDIECGACLRVLEGHE-ELVRCIRF--DNKRIVSGAYDGKIKVWDLQAA 460
Score = 29.6 bits (65), Expect = 8.2
Identities = 35/167 (20%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 370 DRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDT-PVM 428
D +I ++D LK +L T ++ + + + D + +D+ + +
Sbjct: 246 DNSIKIWDKTSLECLK--VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303
Query: 429 VHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPV----DKSRSREVYHTKRMQHVICVK 484
+H H AVL + +S V+ S D+SI ++ + D + R + + +V+
Sbjct: 304 IH--HNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV--- 356
Query: 485 WTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREK--AAKDYNQKL 529
D KYI+ S + I++W + E + L ++ A Y +L
Sbjct: 357 -DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL 402
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 56.2 bits (134), Expect = 8e-08
Identities = 30/109 (27%), Positives = 56/109 (51%), Gaps = 2/109 (1%)
Query: 408 AANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSR 467
+ +ED ++ +D+ + T +++ H V D+D SP F S S D++ R++ D++
Sbjct: 359 SCSEDMSIRYWDLGSF-TNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTY 417
Query: 468 SREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLT 516
+Y + V CVK+ +S Y+ GS + +RLW A + + T
Sbjct: 418 PLRIY-AGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT 465
Score = 43.5 bits (101), Expect = 6e-04
Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 5/77 (6%)
Query: 216 GHRDGVNCLAKHPEK--LATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCG 273
GH V+C+ HP LAT G+ D VR+W+ Q N +R H G V + G
Sbjct: 424 GHLADVDCVKFHPNSNYLAT---GSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480
Query: 274 TSFFTVGDDKTVKQWKM 290
+ G+D+ +K W +
Sbjct: 481 KYLASAGEDQRLKLWDL 497
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/181 (22%), Positives = 82/181 (45%), Gaps = 16/181 (8%)
Query: 332 IWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDM 391
+W RT P+ + VKF+P + L + ++D+ + L+ +Q + ++
Sbjct: 410 LWSFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSAQQGNSV-RLFTGH 467
Query: 392 R--TNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEF 449
R ++ ++P ++ +A ED L +D+ A T H + + +SP
Sbjct: 468 RGPVLSLAFSPNGKYL-ASAGEDQRLKLWDL-ASGTLYKELRGHTDNITSLTFSPDSGLI 525
Query: 450 VSASFDKSIRIF---------PVDKSRSREV-YHTKRMQHVICVKWTSDSKYIMCGSDEM 499
SAS D S+R++ P D S S V +T +M +V+ V++ + + ++ G +
Sbjct: 526 ASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQE 585
Query: 500 N 500
N
Sbjct: 586 N 586
Score = 31.6 bits (70), Expect = 2.2
Identities = 25/105 (23%), Positives = 48/105 (45%), Gaps = 16/105 (15%)
Query: 427 VMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKR--MQHVICVK 484
V + H VL + +SP GK SA D+ ++++ + S +Y R ++ +
Sbjct: 461 VRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL---ASGTLYKELRGHTDNITSLT 517
Query: 485 WTSDSKYIMCGSDEMNIRLW-----------KANASEKLGVLTSR 518
++ DS I S + ++R+W ++SE +GV T +
Sbjct: 518 FSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQ 562
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/125 (27%), Positives = 67/125 (53%), Gaps = 8/125 (6%)
Query: 169 TKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKP---FLASLDGHRDGVNCLA 225
T + L+RV + A++ + +YI + + + +V+ F+ +L+GH+ G+ CL
Sbjct: 378 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACL- 436
Query: 226 KHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTV 285
++ ++L V+SG+ D +R+W++ C+R ++ HE VR C RF + D +
Sbjct: 437 QYRDRL--VVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDGKI 492
Query: 286 KQWKM 290
K W +
Sbjct: 493 KVWDL 497
Score = 45.8 bits (107), Expect = 1e-04
Identities = 59/287 (20%), Positives = 118/287 (41%), Gaps = 62/287 (21%)
Query: 220 GVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTV 279
GV CL +K ++SG D ++IW+ C R + H G V +C ++ T
Sbjct: 269 GVYCLQYDDQK---IVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITG 323
Query: 280 GDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN 339
D TV+ W ++ E L+T++ HH
Sbjct: 324 SSDSTVRVWDVN------TGEMLNTLI---------HHC--------------------- 347
Query: 340 PICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQAT--PLKKVILDMRTNTIC 397
+++ ++FN ++ +C+ DR+I ++DM T L++V++ R
Sbjct: 348 ---------EAVLHLRFN---NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 398 WNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKS 457
+ + +I +A+ D + ++ + V H + + Y + VS S D +
Sbjct: 396 VDFDDKYIVSASG-DRTIKVWNTSTCEF-VRTLNGHKRGIACLQY--RDRLVVSGSSDNT 451
Query: 458 IRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLW 504
IR++ ++ V + V C+++ D+K I+ G+ + I++W
Sbjct: 452 IRLWDIECGACLRVLEGHE-ELVRCIRF--DNKRIVSGAYDGKIKVW 495
Score = 38.1 bits (87), Expect = 0.023
Identities = 37/167 (22%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 214 LDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCG 273
L GH V CL ++ E++ +++G+ D VR+W++ + T+ H V + RF
Sbjct: 303 LTGHTGSVLCL-QYDERV--IITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNN 357
Query: 274 TSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTIL--GKTVYTGIDHHWKEAVFATCGQQVD 331
T D+++ W M P + L +L + +D K V A+ + +
Sbjct: 358 GMMVTCSKDRSIAVWDMASP----TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 413
Query: 332 IWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDM 378
+W+ + ++ I+ +++ L+ S +SD I L+D+
Sbjct: 414 VWNTSTCEFVRTLNGHKRGIACLQY---RDRLVVSGSSDNTIRLWDI 457
Score = 32.7 bits (73), Expect = 0.97
Identities = 36/168 (21%), Positives = 74/168 (44%), Gaps = 19/168 (11%)
Query: 370 DRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMV 429
D I ++D + K+++ + +C E I T +++ T + ++T M+
Sbjct: 286 DNTIKIWD-KNTLECKRILTGHTGSVLCLQYDERVIITGSSDS----TVRVWDVNTGEML 340
Query: 430 H--MDHVSAVLDVDYSPTGKEFVSASFDKSIRIF----PVDKSRSREVYHTKRMQHVICV 483
+ + H AVL + ++ V+ S D+SI ++ P D + R + + +V+
Sbjct: 341 NTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV-- 396
Query: 484 KWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREK--AAKDYNQKL 529
D KYI+ S + I++W + E + L ++ A Y +L
Sbjct: 397 --DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRL 442
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,509,698
Number of Sequences: 37866
Number of extensions: 1237164
Number of successful extensions: 6356
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 204
Number of HSP's that attempted gapping in prelim test: 5001
Number of HSP's gapped (non-prelim): 1231
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.