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Search of human proteins with 22749117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749117 hypothetical protein LOC152405 [Homo sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749117 hypothetical protein LOC152405 [Homo sapiens] 1068 0.0
gi|153251865 hypothetical protein LOC84226 [Homo sapiens] 62 2e-09
gi|62122917 filaggrin family member 2 [Homo sapiens] 52 2e-06
gi|60097902 filaggrin [Homo sapiens] 48 2e-05
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 47 4e-05
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 45 1e-04
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 45 1e-04
gi|14149902 hypothetical protein LOC84167 [Homo sapiens] 45 2e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 44 3e-04
gi|199559779 coiled-coil domain containing 8 [Homo sapiens] 44 3e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 44 5e-04
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 44 5e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 44 5e-04
gi|52426743 cisplatin resistance-associated overexpressed protei... 43 6e-04
gi|19923485 cisplatin resistance-associated overexpressed protei... 43 6e-04
gi|56606114 trichohyalin-like 1 [Homo sapiens] 43 6e-04
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens] 42 0.001
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 42 0.001
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 42 0.002
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 41 0.003
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 41 0.003
gi|24415404 MDN1, midasin homolog [Homo sapiens] 41 0.003
gi|115430241 SCY1-like 1 isoform A [Homo sapiens] 40 0.005
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 40 0.005
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 40 0.005
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 40 0.005
gi|112821681 G protein-regulated inducer of neurite outgrowth 1 ... 40 0.005
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 40 0.007
gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo ... 40 0.007
gi|47578107 delangin isoform B [Homo sapiens] 40 0.007
>gi|22749117 hypothetical protein LOC152405 [Homo sapiens]
Length = 536
Score = 1068 bits (2762), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVP 60
MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVP
Sbjct: 1 MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVP 60
Query: 61 SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASS 120
SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASS
Sbjct: 61 SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASS 120
Query: 121 QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDH 180
QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDH
Sbjct: 121 QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDH 180
Query: 181 RMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSV 240
RMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSV
Sbjct: 181 RMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSV 240
Query: 241 QIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDH 300
QIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDH
Sbjct: 241 QIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDH 300
Query: 301 KTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQL 360
KTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQL
Sbjct: 301 KTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQL 360
Query: 361 SYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATTIPP 420
SYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATTIPP
Sbjct: 361 SYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATTIPP 420
Query: 421 YNPVDARFTSNFQAKDQALFPRLPSILSKLNYTSSQEKTQAIVTKSDEFSEIDQGKGYHI 480
YNPVDARFTSNFQAKDQALFPRLPSILSKLNYTSSQEKTQAIVTKSDEFSEIDQGKGYHI
Sbjct: 421 YNPVDARFTSNFQAKDQALFPRLPSILSKLNYTSSQEKTQAIVTKSDEFSEIDQGKGYHI 480
Query: 481 RNQTYRRFPSIVYEDPYQVSLQYMEKHHILQIFQQITENLVYEKPEDPLNFMLCQV 536
RNQTYRRFPSIVYEDPYQVSLQYMEKHHILQIFQQITENLVYEKPEDPLNFMLCQV
Sbjct: 481 RNQTYRRFPSIVYEDPYQVSLQYMEKHHILQIFQQITENLVYEKPEDPLNFMLCQV 536
>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
Length = 1984
Score = 61.6 bits (148), Expect = 2e-09
Identities = 66/291 (22%), Positives = 118/291 (40%), Gaps = 28/291 (9%)
Query: 5 PQEALAEPLKHESPAAPSSAGHT-KGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQA 63
P E L +PS H Q ++ ++ + +HR + + R PSQ
Sbjct: 1617 PPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQR 1676
Query: 64 ESSIFSQATNGVAEQNGHSTPGQAG------RRASNPADVSDLRADDQVNQTPSEQTKGK 117
S+ ++ + H +P Q RR +P+ S + +++PSE++
Sbjct: 1677 SHRGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHS 1736
Query: 118 ASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQ 177
S +++ H S+ + +E +ER + +ERR + R PS++
Sbjct: 1737 PSERSH---HSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSP 1793
Query: 178 TDHRMAGQSERRASEQMDRRMSGEAERR---TSEQITHRLSKLSERRPSVQIDSGSSVPS 234
++ SERR ++R ER SE+ +HR + S RR I S PS
Sbjct: 1794 SERSHHSPSERRRHSPLERSRHSLLERSHRSPSERRSHRSFERSHRR----ISERSHSPS 1849
Query: 235 DQSPSVQIDSGSSVPSDQR-----------PSVQIDRRMSGKVRRRSSEKT 274
++S ++ PS++R PS + R SG + R+SE++
Sbjct: 1850 EKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQGRTSERS 1900
Score = 59.7 bits (143), Expect = 7e-09
Identities = 61/272 (22%), Positives = 113/272 (41%), Gaps = 20/272 (7%)
Query: 20 APSSAGHTKGQEEDDQKNQAER-KADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQ 78
+PS H E + + R ++ + +HR + + PS+ SQ ++ +
Sbjct: 1648 SPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSE 1707
Query: 79 NGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLT 138
H +P + R +PA S ++ + +PSE++ S + + H S+ +
Sbjct: 1708 RRHHSPSKRSHR--SPARRSHRSPSERSHHSPSERSHHSPSERRH---HSPSERSHCSPS 1762
Query: 139 EERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRM 198
E +ERR + +ERR + PS++ ++ R ER ++R
Sbjct: 1763 ERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLER-- 1820
Query: 199 SGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQI 258
+ R SE+ +HR + S RR I S PS++S ++ PS++R
Sbjct: 1821 ---SHRSPSERRSHRSFERSHRR----ISERSHSPSEKSHLSPLERSRCSPSERR----- 1868
Query: 259 DRRMSGKVRRRSSEKTDYRLAGLADPGTSEQT 290
SGK SE++ +G+ TSE++
Sbjct: 1869 GHSSSGKTCHSPSERSHRSPSGMRQGRTSERS 1900
Score = 55.5 bits (132), Expect = 1e-07
Identities = 50/244 (20%), Positives = 104/244 (42%), Gaps = 19/244 (7%)
Query: 14 KHESPAAPSSAGHTKGQEEDDQKN------QAERKADNHTAHRIADQTALRVPSQAESSI 67
+H SP+ S G ++ + K + ++ + +H + + PS+
Sbjct: 1693 RHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHS 1752
Query: 68 FSQATNGVAEQNGHSTPGQ------AGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQ 121
S+ ++ + H +P + + RR +P++ S ++ + +PSE+ + +
Sbjct: 1753 PSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLER 1812
Query: 122 ANNVQHEQSDGQVSGLTEERTAEQTERRLPTQA----ERRTSGQIDGRLAMPSDQRG--- 174
+ + E+S S R+ E++ RR+ ++ E+ ++ PS++RG
Sbjct: 1813 SRHSLLERSHRSPSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSS 1872
Query: 175 SRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPS 234
S +T H + +S R S R S + R + E+ H S++ RPS + S S
Sbjct: 1873 SGKTCHSPSERSHRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHCSPSERS 1932
Query: 235 DQSP 238
+SP
Sbjct: 1933 RRSP 1936
Score = 53.9 bits (128), Expect = 4e-07
Identities = 74/366 (20%), Positives = 147/366 (40%), Gaps = 44/366 (12%)
Query: 15 HESPAAPSSAGHTKGQEED-DQKNQAERKADNHTAHRIADQTALRVPSQA------ESSI 67
H SP+ S + + Q++ NH++ + + R PSQ E S
Sbjct: 1566 HRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSS---PSERSWRSPSQRNHCSPPERSC 1622
Query: 68 FSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQH 127
S + G+ + S G + RR +P++ S +++PSE++ +S + +
Sbjct: 1623 HSLSERGLHSPSQRSHRGPSQRRHHSPSERS--------HRSPSERSHRSSSERRHRSPS 1674
Query: 128 EQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSE 187
++S G +E +ERR + ++R G + R P S+++ A +S
Sbjct: 1675 QRSH---RGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSP-----SKRSHRSPARRSH 1726
Query: 188 RRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSS 247
R SE+ S + SE+ H S+ S PS + S +SPS + S
Sbjct: 1727 RSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPS 1786
Query: 248 VPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTH 307
S PS + S + R E++ + L + SE+ H++ ++H
Sbjct: 1787 EKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERR--------SHRSFERSH 1838
Query: 308 HQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHK-DQLSYYETR 366
++ ++ H +++H + P++ + + S++ H + + H + S+
Sbjct: 1839 RRISERS-----HSPSEKSHLS----PLERSRCSPSERRGHSSSGKTCHSPSERSHRSPS 1889
Query: 367 GQSEDR 372
G + R
Sbjct: 1890 GMRQGR 1895
Score = 29.6 bits (65), Expect = 7.2
Identities = 48/256 (18%), Positives = 90/256 (35%), Gaps = 17/256 (6%)
Query: 110 PSEQTKGKASSQAN------NVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQID 163
P++ G A A+ VQ + S T+ Q + L T R Q
Sbjct: 1457 PTDSQSGIAFQTASVGQPLRTVQKDSSSRSKKNFYRNETSSQESKNLSTPGTRV---QAR 1513
Query: 164 GRL--AMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERR 221
GR+ P + R ++ + S +R G +ER H S + R
Sbjct: 1514 GRILPGSPVKRTWHRHLKDKLTHKEHNHPSFYRERTPRGPSERTR-----HNPSWRNHRS 1568
Query: 222 PSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGL 281
PS + S SPS + S + PS + R S + E++ + L+
Sbjct: 1569 PSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRNHCSPPERSCHSLSER 1628
Query: 282 ADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYT 341
S+++ H S ++H ++ + + + + P + +H +
Sbjct: 1629 GLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSHCS 1688
Query: 342 ESDQTDHLADRQANHK 357
S++ H + Q +H+
Sbjct: 1689 PSERR-HRSPSQRSHR 1703
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 51.6 bits (122), Expect = 2e-06
Identities = 86/380 (22%), Positives = 135/380 (35%), Gaps = 61/380 (16%)
Query: 17 SPAAPSSAGHTKGQEEDDQKNQAERKADNH-TAHRIADQTALRVPSQAESSIFSQATNGV 75
S + + GHT GQ + H T H QT +++ + +G+
Sbjct: 1663 SGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTH---GQTG-------DTTRHAHYHHGL 1712
Query: 76 AEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQ---ANNVQHEQSDG 132
Q G T GRR S ++ SD V+ T S T G+A SQ + ++ HE+ G
Sbjct: 1713 TTQTGSRT---TGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHER-HG 1768
Query: 133 QVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASE 192
+ G T + T+ GQ S Q GSR T R +G SE SE
Sbjct: 1769 TIHGQTGD----------TTRHAHSGHGQ--------STQTGSRTTGRRSSGHSEYSDSE 1810
Query: 193 QMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQ 252
SG ++R S TH + +D Q+ D+ S
Sbjct: 1811 ----GHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTG----DTSGHSQSGH 1862
Query: 253 RPSVQIDRRMSGKVRRRSSEKTDYRL--AGLADPGTSEQTDLRLYGLVDHKTSVKTHHQV 310
S Q +G+ R SE +D + G + R T K H
Sbjct: 1863 GQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTT 1922
Query: 311 YGQATELAEH------QAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYE 364
+GQ + EH Q I + ++ Y++S+ ++ + H
Sbjct: 1923 HGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGH-------- 1974
Query: 365 TRGQSEDRIFPQLGNSKEDK 384
T GQ+ +P+ G+S ++
Sbjct: 1975 THGQAGSH-YPESGSSVHER 1993
Score = 50.4 bits (119), Expect = 4e-06
Identities = 80/323 (24%), Positives = 117/323 (36%), Gaps = 68/323 (21%)
Query: 17 SPAAPSSAGHTKGQEEDDQKNQAERKADNH-TAHRIADQTALRVPSQAESSIFSQATNGV 75
S + + +GHT GQ + H T H QTA +++ + +G
Sbjct: 1965 SGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTH---GQTA-------DTTRHGHSGHGQ 2014
Query: 76 AEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQV- 134
+ Q G T GRRAS ++ SD V+ T S G+A S QH +S V
Sbjct: 2015 STQRGSRT---TGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGS-----QHGESGSSVH 2066
Query: 135 --SGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASE 192
G T +T + T + S QRGSR R +G SE
Sbjct: 2067 ERHGTTHGQTGDTTRHAHSGHGQ--------------STQRGSRTAGRRGSGHSE----- 2107
Query: 193 QMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSV---P 249
S ++E + TH + R S +SGS++ Q ++ +G +
Sbjct: 2108 ------SSDSEVHSGVSHTHSGHTYGQAR-SQHGESGSAIHGRQG-TIHGQTGDTTRHGQ 2159
Query: 250 SDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRL------YGLVDHKTS 303
S S Q R +G+ R SE +D + A P S T + G H
Sbjct: 2160 SGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQ 2219
Query: 304 VKTH----------HQVYGQATE 316
TH H YGQ+T+
Sbjct: 2220 GTTHGQTGDTTRHAHYGYGQSTQ 2242
Score = 47.4 bits (111), Expect = 3e-05
Identities = 88/369 (23%), Positives = 131/369 (35%), Gaps = 50/369 (13%)
Query: 21 PSSAGHTKGQEEDDQKNQAERKADNH-TAH-RIADQTALRVPSQAESSIFSQATNGVAEQ 78
P S HT GQ + + H T H +I D T S + +G + Q
Sbjct: 1592 PHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTG-----------HSHSGHGQSTQ 1640
Query: 79 NGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQV---S 135
G T GR+ S+ ++ SD V+ T + T G+A S QH QS+ V
Sbjct: 1641 RGSRT---TGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGS-----QHGQSESIVPERH 1692
Query: 136 GLTEERTAEQTERR-----LPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRA 190
G T +T + T L TQ RT+G+ + SD G H +G + +A
Sbjct: 1693 GTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQA 1752
Query: 191 SEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPS 250
R GE+E E+ + + G S + + + SG S S
Sbjct: 1753 -----RSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYS 1807
Query: 251 DQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQV 310
D SG +R S + AG + G SE +G +T + H
Sbjct: 1808 DSEGH-------SGFSQRPHSRGHTHGQAG-SQHGESESIVDERHGTTHGQTGDTSGHSQ 1859
Query: 311 --YGQATELAEHQA--IDQAHSNADQPPV-DNAHYTESDQTDHLADRQANHKDQL---SY 362
+GQ+T+ HS + V +T S T A Q + +
Sbjct: 1860 SGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRH 1919
Query: 363 YETRGQSED 371
T GQ+ D
Sbjct: 1920 QTTHGQTGD 1928
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/267 (25%), Positives = 99/267 (37%), Gaps = 38/267 (14%)
Query: 116 GKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGS 175
G S Q+ + +S SG T E T + SGQ S Q GS
Sbjct: 1209 GSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQ------STQTGS 1262
Query: 176 RQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSK-LSERRPSVQIDSGSSVPS 234
R T R + QSE SE +++HR S+ + + S SGS+V
Sbjct: 1263 RVTRRRRSSQSENSDSE-------------VHSKVSHRHSEHIHTQAGSHYPKSGSTVRR 1309
Query: 235 DQSPS--VQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRL-AGLAD-PGTSEQT 290
Q + + D+ S S Q R SG+ R S+ TD + +G++ P + EQT
Sbjct: 1310 RQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQT 1369
Query: 291 DLRLYGLVDHKTSV--KTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYT------E 342
+ S + H YGQ E H HS Q + T
Sbjct: 1370 HSQAGSQHGESESTVHERHETTYGQTGEATGH-----GHSGHGQSTQRGSRTTGRRGSGH 1424
Query: 343 SDQTDHLADRQANHKDQLSYYETRGQS 369
S+ +D +H+ Q S +T GQ+
Sbjct: 1425 SESSDSEVHSGGSHRPQ-SQEQTHGQA 1450
Score = 41.2 bits (95), Expect = 0.002
Identities = 86/369 (23%), Positives = 139/369 (37%), Gaps = 53/369 (14%)
Query: 17 SPAAPSSAGHTKGQEEDDQKNQAERKADNH-TAHRIADQTALRVPSQAESSIFSQATNGV 75
S + + +GH GQ + H T H QT +++ + + +G
Sbjct: 2040 SGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTH---GQTG-------DTTRHAHSGHGQ 2089
Query: 76 AEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQ---ANNVQHEQSDG 132
+ Q G T AGRR S ++ SD V+ T S T G+A SQ + + H + G
Sbjct: 2090 STQRGSRT---AGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGR-QG 2145
Query: 133 QVSGLTEERTAE-QTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRA- 190
+ G T + T Q+ TQ RT+G+ + SD + +G + +A
Sbjct: 2146 TIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAG 2205
Query: 191 SEQMDRRMSGEAERRTSE---------------QITHRLSKLSERRPSVQIDSG-SSVPS 234
S SG + T+ Q T R S+ + RR S +S S V S
Sbjct: 2206 SRHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHS 2265
Query: 235 DQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRL 294
S + S QR Q + G++ + D G + G S QT R
Sbjct: 2266 WGSHTHSGHIQGQAGSQQR---QPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSR- 2321
Query: 295 YGLVDHKTSVKTHHQVYGQATELAEHQAIDQAH----------SNADQPPVDNAHYTESD 344
H S + Q +G ++++ +H + A S + + N+H + S
Sbjct: 2322 SSRASHFQSHSSERQRHG-SSQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWS- 2379
Query: 345 QTDHLADRQ 353
TD A++Q
Sbjct: 2380 -TDSTANKQ 2387
Score = 33.9 bits (76), Expect = 0.38
Identities = 81/375 (21%), Positives = 125/375 (33%), Gaps = 47/375 (12%)
Query: 14 KHESPAAPSSAG-HTKGQEEDDQKNQ-AERKADNHTAHRIADQTALRVPSQAESSIFSQA 71
+HES + SS G H+ G + Q R+ H ++S+ F Q
Sbjct: 760 QHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHG---------SGSSQSTGFGQY 810
Query: 72 TNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNV-QHEQS 130
+G + G G+ S S + + S G SSQ++ QH S
Sbjct: 811 GSGSGQSAGF------GQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSS 864
Query: 131 DGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRA 190
GQ SG + R++ SGQ G Q G+ + GQ E R
Sbjct: 865 SGQTSGFGQHRSSSGQYSGFGQHGS--GSGQSSG-----FGQHGTGSGQYSGFGQHESR- 916
Query: 191 SEQMDRRMSGEAERRTSEQITHRLSK-----LSERRPSVQIDSGSSVPSDQSPSVQIDSG 245
S Q G ++S H S + R SG S Q S SG
Sbjct: 917 SHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSG----SGQSSGFGQHGS---GSG 969
Query: 246 SSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVK 305
S Q S G+ RSS+ G G+S+ + +G +T+
Sbjct: 970 QSSGFGQHESGSGKSSGFGQHESRSSQSN----YGQHGSGSSQSSGYGQHGSSSGQTTGF 1025
Query: 306 THHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYET 365
H+ + ++ Q S +DQ H T S Q+ ++ +
Sbjct: 1026 GQHR-----SSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHG 1080
Query: 366 RGQSEDRIFPQLGNS 380
G S+ + Q G++
Sbjct: 1081 SGSSQSSGYGQHGSN 1095
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 48.1 bits (113), Expect = 2e-05
Identities = 104/510 (20%), Positives = 161/510 (31%), Gaps = 81/510 (15%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQK--NQAERKADNHTA--HRIADQTA-LRVP 60
QE + +H + AGH E Q + AE + A H A +A R
Sbjct: 3568 QEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHG 3627
Query: 61 SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPS--------- 111
S + S S +G+ S +G R S+ + SD + + T S
Sbjct: 3628 SHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGP 3687
Query: 112 ------EQTKGKASSQANN--------VQHEQSDGQVSGLTEERTAEQTERRLPTQAERR 157
E T+G+++ ++ HEQS+ Q R + R
Sbjct: 3688 HQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSR 3747
Query: 158 TSGQIDGRLAM---PSDQRGSRQTDH----------------RMAGQSERRASEQMDRRM 198
S +G+ + P +RG RQ + Q AS
Sbjct: 3748 HSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSR 3807
Query: 199 SGEAERRTSEQI--THRLSKLSERRPSVQIDSGSSVPSDQSPSV----QIDSGSSVPSDQ 252
S E R EQ R S S Q DS S Q S GSSV D
Sbjct: 3808 SASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDS 3867
Query: 253 RPSV---QIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQ 309
+RR R + G PG+S + D + S + +
Sbjct: 3868 DSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHR-DTASHVQSSPVQSDSSTAK 3926
Query: 310 VYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYETRGQS 369
+G + L++ A + P ++++ +S+ T +RQ + + + G
Sbjct: 3927 EHGHFSSLSQDSAYHSGIQSRGSPHSSSSYHYQSEGT----ERQKGQSGLVWRHGSYG-- 3980
Query: 370 EDRIFPQLGNSKEDKEADYRVQPCKFEDSQ---VDLNSKPSVEMETQNATTIPPYNPVDA 426
ADY F SQ V NS P V E + +
Sbjct: 3981 ---------------SADYDYGESGFRHSQHGSVSYNSNPVVFKERSDICKASAFGKDHP 4025
Query: 427 RFTSNFQAKDQALFPRLPSILSKLNYTSSQ 456
R+ + + KD L I +L ++ SQ
Sbjct: 4026 RYYATYINKDPGLCGHSSDISKQLGFSQSQ 4055
Score = 42.4 bits (98), Expect = 0.001
Identities = 88/439 (20%), Positives = 136/439 (30%), Gaps = 68/439 (15%)
Query: 3 EPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTA---HRIADQTALRV 59
E + P H+ A S GH+ AE + A + R
Sbjct: 1624 EQSRHGSRNPRSHQEDRA--SHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERH 1681
Query: 60 PSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKAS 119
S+ + S S +G + S G +G R S+ + SD + + T S G+A
Sbjct: 1682 GSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAG 1741
Query: 120 SQANNVQH-------EQSDGQVSGLTEERTAEQTE----RRLPTQAERRTSGQIDGR--- 165
+ Q E+S S L + T EQ+E R P+ R+ S R
Sbjct: 1742 PHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSS 1801
Query: 166 ------------LAMPSDQRGSRQTDHR-------------------------MAGQSER 188
P RG RQ H GQS
Sbjct: 1802 RHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGS 1861
Query: 189 RASEQMDR--RMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGS 246
R+ + R + SG+ R + + H S ++ Q+ G S P + GS
Sbjct: 1862 RSVSRQTRNEKQSGDGSRHSGSR-HHEASSRADSSRHSQVGQGQS----SGPRTSRNQGS 1916
Query: 247 SV--PSDQRPSVQIDRRMSGKV-RRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTS 303
SV SD + + R SG R + G PG+ + D
Sbjct: 1917 SVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQ 1976
Query: 304 VKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYY 363
T H + A +QA S+A + + +D + H +
Sbjct: 1977 SGTRHTESSSRGQAASSH--EQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDS 2034
Query: 364 ETRGQSEDRIFPQLGNSKE 382
RG S + G+S++
Sbjct: 2035 GHRGYSGSQASDSEGHSED 2053
Score = 41.2 bits (95), Expect = 0.002
Identities = 94/443 (21%), Positives = 135/443 (30%), Gaps = 79/443 (17%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQ-------TALR 58
QE L + +H AGH G D + R + + A R
Sbjct: 2596 QEQLRDGSRHPRSHQEDRAGH--GHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGER 2653
Query: 59 VPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKA 118
S + S S +G+ S +G R + + SD + + T S G+A
Sbjct: 2654 HGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQA 2713
Query: 119 SSQANNVQ-----------------------HEQSDGQVSGLTEERTAEQTERRLPTQAE 155
S + Q HEQS+ Q R Q
Sbjct: 2714 GSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDS 2773
Query: 156 RRTSGQIDGRLAM---PSDQRGSRQTDHR-------------------------MAGQSE 187
R S DG+ + P RG RQ H GQS
Sbjct: 2774 SRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSG 2833
Query: 188 RRASEQMDR--RMSGEAER----RTSEQITHRLSKLSERRPSVQIDS-GSSVPSDQSPSV 240
R++ + R SG+ R R E TH + +S +VQ S GS Q SV
Sbjct: 2834 SRSASRTTRNEEQSGDGSRHSGSRHHEASTH--ADISRHSQAVQGQSEGSRRSRRQGSSV 2891
Query: 241 QIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYG-LVD 299
DS S S+ R SG R +L + S Q D +G D
Sbjct: 2892 SQDSDSEGHSED------SERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSAD 2945
Query: 300 HKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQ 359
T H + A +QA S+A + + H +D + H
Sbjct: 2946 SSRQSGTRHTQTSSGGQAASSH--EQARSSAGERH-GSHHQQSADSSRHSGIGHGQASSA 3002
Query: 360 LSYYETRGQSEDRIFPQLGNSKE 382
+ RG S + G+S++
Sbjct: 3003 VRDSGHRGYSGSQASDNEGHSED 3025
Score = 40.4 bits (93), Expect = 0.004
Identities = 87/445 (19%), Positives = 136/445 (30%), Gaps = 80/445 (17%)
Query: 3 EPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQ 62
E ++ P H+ A S GH+ AE + TA + + A P +
Sbjct: 327 EQSRDGSRHPRSHDEDRA--SHGHSADSSRQSGTRHAETSSRGQTAS--SHEQARSSPGE 382
Query: 63 AESSIFSQATNGVAEQNGHSTPGQA---------GRRASNPADVSDLRADDQVNQTPSEQ 113
S Q+ A+ + HS G+ G R S+ + SD + + T S
Sbjct: 383 RHGSGHQQS----ADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVS 438
Query: 114 TKGKAS--SQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAM--- 168
GKA Q++ G+ SG + + + P A RT GR
Sbjct: 439 GHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHE 498
Query: 169 ---------------------PSDQRGSRQTDHR-------------------------M 182
P RG RQ H
Sbjct: 499 QARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDAS 558
Query: 183 AGQSERRASEQMDR--RMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSV 240
GQS R++ + R SG+ R + + H S ++ Q+ G S P
Sbjct: 559 HGQSGSRSASRQTRNEEQSGDGTRHSGSR-HHEASSQADSSRHSQVGQGQS----SGPRT 613
Query: 241 QIDSGSSV--PSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYG-L 297
+ GSSV SD + + R SG R + + S D +G
Sbjct: 614 SRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHS 673
Query: 298 VDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHK 357
D T H + + A +QA S+A + +D + H
Sbjct: 674 ADSSRKSGTRHTQNSSSGQAASSH--EQARSSAGERHGSRHQLQSADSSRHSGTGHGQAS 731
Query: 358 DQLSYYETRGQSEDRIFPQLGNSKE 382
+ RG S + G+S++
Sbjct: 732 SAVRDSGHRGSSGSQATDSEGHSED 756
Score = 37.4 bits (85), Expect = 0.035
Identities = 74/332 (22%), Positives = 104/332 (31%), Gaps = 71/332 (21%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQ-------TALR 58
QE L + +H AGH G D + R + + A R
Sbjct: 2920 QEQLRDGSRHPRSHQEDRAGH--GHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGER 2977
Query: 59 VPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKA 118
S + S S +G+ S +G R + + SD + + T S G+A
Sbjct: 2978 HGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQA 3037
Query: 119 SSQANNVQ-----------------------HEQSDGQVSGLTEERTAEQTERRLPTQAE 155
S + Q HEQS+ Q R Q
Sbjct: 3038 GSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDS 3097
Query: 156 RRTSGQIDGRLAM---PSDQRGSRQTDHR-------------------------MAGQSE 187
R S G+ + P RG RQ H GQS
Sbjct: 3098 SRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSG 3157
Query: 188 RRASEQMDR--RMSGEAER----RTSEQITHRLSKLSERRPSVQIDS-GSSVPSDQSPSV 240
R++ + R SG++ R R E TH + +S +VQ S GS Q SV
Sbjct: 3158 SRSASRTTRNEEQSGDSSRHSVSRHHEASTH--ADISRHSQAVQGQSEGSRRSRRQGSSV 3215
Query: 241 QIDSGSSVPSD--QRPSVQIDRRMSGKVRRRS 270
DS S S+ +R S R G V+ +S
Sbjct: 3216 SQDSDSEGHSEDSERWSGSASRNHRGSVQEQS 3247
Score = 36.6 bits (83), Expect = 0.059
Identities = 78/379 (20%), Positives = 131/379 (34%), Gaps = 26/379 (6%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQK--NQAERKADNHTA--HRIADQTA-LRVP 60
QE + +H AGH E Q + AE + A H A +A R
Sbjct: 2272 QEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHG 2331
Query: 61 SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASS 120
S + S S +G+ S +G R S+ + SD + + T S G+A
Sbjct: 2332 SHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAG- 2390
Query: 121 QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQ-TD 179
H+QS + T R+A ++ R + T Q + G RQ +
Sbjct: 2391 -----PHQQSHQE---STRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSH 2442
Query: 180 HRMAGQSERRASEQMDR-RMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSP 238
H+ A S R ++ Q + + G + + +L +R + +S
Sbjct: 2443 HKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSD 2502
Query: 239 SVQIDSGSSVPSDQRPSVQID---RRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLY 295
+ SGS S Q + + R SG +S + D +G + G + R
Sbjct: 2503 ASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRAD--SSGHSQVGQGQSEGPRTS 2560
Query: 296 GLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTD-----HLA 350
S + Q + + +E A H +A + D + + S Q D H A
Sbjct: 2561 RNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSA 2620
Query: 351 DRQANHKDQLSYYETRGQS 369
D + + + GQ+
Sbjct: 2621 DSSRQSGTRHTQTSSGGQA 2639
Score = 36.2 bits (82), Expect = 0.077
Identities = 92/437 (21%), Positives = 141/437 (32%), Gaps = 100/437 (22%)
Query: 22 SSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGH 81
SS G E + + ER +H S S I + +GH
Sbjct: 1985 SSRGQAASSHEQARSSAGERHGSHHQLQS--------ADSSRHSGIGHGQASSAVRDSGH 2036
Query: 82 STPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSG----- 136
G +G +AS+ S+ ++D Q+ S Q K Q++ G+ SG
Sbjct: 2037 R--GYSGSQASD----SEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSF 2090
Query: 137 LTEERTAEQTE----RRLPTQAER------------RTSGQIDGRLAM---PSDQRGSRQ 177
L + T EQ+E + P+ R R S +G+ + P RG RQ
Sbjct: 2091 LYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQ 2150
Query: 178 TDHR-------------------------MAGQSERRASEQM--DRRMSGEAERRTSEQI 210
H+ GQS R++ + D+ SG+ R +
Sbjct: 2151 GSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHH 2210
Query: 211 THRLSKLSERRPSVQIDSGSSVPSDQSP---SVQIDSGSSVPSD--QRPSVQIDRRMSGK 265
S R S+ SS P P SV DS S S+ +R S R G
Sbjct: 2211 HEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGS 2270
Query: 266 VRRRSSEKTDYRLAGLADPG-------TSEQTDLRLYGLVDHKTSVKTHHQV-------- 310
+ +S + + + + D +S Q+ + +H Q
Sbjct: 2271 AQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERH 2330
Query: 311 ---YGQATELAEHQAI----------DQAH--SNADQPPVDNAHYTESDQTDHLADRQAN 355
+ Q+ + + H I D H S+ Q H +SD A QA
Sbjct: 2331 GSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAG 2390
Query: 356 HKDQLSYYETRGQSEDR 372
Q TRG+S R
Sbjct: 2391 PHQQSHQESTRGRSAGR 2407
Score = 34.7 bits (78), Expect = 0.23
Identities = 75/369 (20%), Positives = 114/369 (30%), Gaps = 41/369 (11%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAE- 64
QE + +H AGH G D + R N ++ + A S E
Sbjct: 650 QEQSRDGSRHPRSHHEDRAGH--GHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGER 707
Query: 65 -------SSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGK 117
S S +G S +G R S+ + +D + + T S G+
Sbjct: 708 HGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQ 767
Query: 118 ASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQ 177
A H Q Q S +R+ E++ R + T Q + G RQ
Sbjct: 768 AG-------HHQQSHQES--ARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQ 818
Query: 178 TDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQS 237
H + R S D G+ R + R + S SV S +
Sbjct: 819 GSHHEQARDNSRHSASQD----GQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHT 874
Query: 238 PSVQIDSGSSVPSDQRPSVQIDR---------RMSGKVRRRSSEKTDYRLAGLADPGTSE 288
S S S R + + R R SG +S D A G SE
Sbjct: 875 TSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSE 934
Query: 289 --QTDLRLYGLVDHKTSVKTH----HQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTE 342
+T R V + + H + G A+ A +Q+ + P +H+ +
Sbjct: 935 GSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHP---RSHHED 991
Query: 343 SDQTDHLAD 351
H AD
Sbjct: 992 RAGHGHSAD 1000
Score = 33.9 bits (76), Expect = 0.38
Identities = 81/421 (19%), Positives = 143/421 (33%), Gaps = 71/421 (16%)
Query: 24 AGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATN-----GVAEQ 78
A H + Q ++ +H + + A P + S Q+ + G+ +
Sbjct: 1317 ASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHR 1376
Query: 79 NGHSTPGQAGRRASNPADVSDLRADDQVNQT----------PSEQT--------KGKASS 120
S +G R S+ + V++ + + T P +Q+ G++S
Sbjct: 1377 QASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSG 1436
Query: 121 QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAER-----RTSGQIDGRLAM---PSDQ 172
++ + ++ S + S T +TA T R ++ E+ R S DG+ + P
Sbjct: 1437 RSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSS 1496
Query: 173 RGSRQTDHR-------------------------MAGQSERRASEQMDR--RMSGEAERR 205
RG RQ + GQS R++ + R SG+ R
Sbjct: 1497 RGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRH 1556
Query: 206 TSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSD---QRPSVQIDRRM 262
+ + ++ R S Q+ G S S S GSSV D + S +RR
Sbjct: 1557 SGSRHHEPSTRAGSSRHS-QVGQGESAGSKTSRR----QGSSVSQDRDSEGHSEDSERRS 1611
Query: 263 SGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYG-LVDHKTSVKTHHQVYGQATELAEHQ 321
R + G +P S Q D +G + T H + A Q
Sbjct: 1612 ESASRNHYGSAREQSRHGSRNP-RSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQ 1670
Query: 322 AIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYETRGQSEDRIFPQLGNSK 381
+QA S+ + + H +D + + + RG S + G+S+
Sbjct: 1671 --EQARSSPGERH-GSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSE 1727
Query: 382 E 382
E
Sbjct: 1728 E 1728
Score = 33.5 bits (75), Expect = 0.50
Identities = 64/312 (20%), Positives = 111/312 (35%), Gaps = 38/312 (12%)
Query: 96 DVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAE 155
D +D ++ S + GK+SSQ N +HE + ++P Q E
Sbjct: 245 DTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTS-----------------QVPLQ-E 286
Query: 156 RRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERR---ASEQMDRRMSGEAERRTSEQITH 212
RT + R++ D G + R +G + R ++ + R S ++ +H
Sbjct: 287 SRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASH 346
Query: 213 RLSKLSERRPSVQIDSGSSVPSDQSPSVQIDS--GSSVPSDQRPSVQIDRRMSGKVRRRS 270
S S R+ + SS S Q S G S + S R + + S
Sbjct: 347 GHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQAS 406
Query: 271 SEKTDYRLAGLA------DPGTSEQTDLRLYGLVDHKTSVKTHHQ--VYGQATELAEHQA 322
S +D G + G SE +D + + HQ G++ E +
Sbjct: 407 SAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSG 466
Query: 323 IDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQL---SYYETRGQSEDRIFPQLGN 379
+ + P D+AH T RQ +H +Q S + + +D I G+
Sbjct: 467 SSLYQVSTHEQP-DSAHGRTGTST---GGRQGSHHEQARDSSRHSASQEGQDTIRGHPGS 522
Query: 380 SKEDKEADYRVQ 391
S+ ++ + Q
Sbjct: 523 SRGGRQGSHHEQ 534
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 47.0 bits (110), Expect = 4e-05
Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 36/276 (13%)
Query: 23 SAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHS 82
S H+KG+ ++ + ++ N + R PS+ S S++++ + G S
Sbjct: 332 SRSHSKGKSQNQSRTPRRGRSHNWS----------RNPSKERSHSHSRSSSKERDHRGSS 381
Query: 83 TP---------GQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQ 133
+P G ++ + S +A D+ + + ++ S++ N + S +
Sbjct: 382 SPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSR 441
Query: 134 VSGLTEERTAEQTERRLPTQAERRTSGQID--GRLAMPSDQRG-------SRQTDHRMAG 184
+R+ ++ + + R+ + R PS +R S++ DHR +
Sbjct: 442 SPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSR 501
Query: 185 QSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQID-SGSSVPSDQSPSVQID 243
+ + R S E + R S + + R P+ + D S S PS++ Q
Sbjct: 502 SPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR 561
Query: 244 SGSSVPSDQR---PSVQIDRRMSGKVRRRSSEKTDY 276
S S +R PS + +RR S R SSE+ D+
Sbjct: 562 SPSKERDRRRWRSPSKERERRQS----RSSSEERDH 593
Score = 45.4 bits (106), Expect = 1e-04
Identities = 70/334 (20%), Positives = 124/334 (37%), Gaps = 28/334 (8%)
Query: 2 EEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPS 61
+E + P K + S + + +A ++ + + ++ D + R P
Sbjct: 385 KESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPY 444
Query: 62 QAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQ 121
+A S++ N + + +P +A R S S R Q+ E+ ++ S
Sbjct: 445 KARDRSRSRSPNKARDHSRSRSPNKA-RDRSRSRSPSKERDHSQLGSPSKERDHRRSRSP 503
Query: 122 ANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHR 181
+ Q QS R+ ++ R Q+ + + PS++R RQ+
Sbjct: 504 SKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQS--- 560
Query: 182 MAGQSERRASEQMDRRM----SGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQS 237
R S++ DRR S E ERR S + R P+ Q SG S P S
Sbjct: 561 ------RSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQ--SGYSRPRASS 612
Query: 238 PSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGL 297
+ S S PS + Q R SS+++D + + +++ R L
Sbjct: 613 KE-KAHSRSRTPSKEGNHSQ---------SRTSSKESDPSQSTVPRSPDWKRSPTRTSSL 662
Query: 298 VDHKTSVKTHHQVYGQATELAEHQAIDQAHSNAD 331
++T KT + +T + Q + Q S AD
Sbjct: 663 SQNRTPSKT--SSHSPSTFPSGGQTLSQDDSQAD 694
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/260 (20%), Positives = 103/260 (39%), Gaps = 18/260 (6%)
Query: 26 HTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIF-------SQATNGVAEQ 78
H K EE+ Q+ + K N H+ + +L +A+ + ++ T+ + +
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
Query: 79 NGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLT 138
H + GR S + ++ + + T S + SS + + + +
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSS-----S 551
Query: 139 EERTAEQTERRLPT-QAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRR 197
+R + R PT +A R S R+ + S++ + D R + ++ + +R
Sbjct: 552 PKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRS 611
Query: 198 MSGEAER---RTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRP 254
S E R R+ ++ T+R S+ S R +ID S S + ++ +R
Sbjct: 612 PSRERRRSRSRSRDRRTNRASR-SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
Query: 255 -SVQIDRRMSGKVRRRSSEK 273
S+ DR+ K R R +K
Sbjct: 671 RSIDKDRKKKDKEREREQDK 690
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/260 (20%), Positives = 103/260 (39%), Gaps = 18/260 (6%)
Query: 26 HTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIF-------SQATNGVAEQ 78
H K EE+ Q+ + K N H+ + +L +A+ + ++ T+ + +
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496
Query: 79 NGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLT 138
H + GR S + ++ + + T S + SS + + + +
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSS-----S 551
Query: 139 EERTAEQTERRLPT-QAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRR 197
+R + R PT +A R S R+ + S++ + D R + ++ + +R
Sbjct: 552 PKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRS 611
Query: 198 MSGEAER---RTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRP 254
S E R R+ ++ T+R S+ S R +ID S S + ++ +R
Sbjct: 612 PSRERRRSRSRSRDRRTNRASR-SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERS 670
Query: 255 -SVQIDRRMSGKVRRRSSEK 273
S+ DR+ K R R +K
Sbjct: 671 RSIDKDRKKKDKEREREQDK 690
>gi|14149902 hypothetical protein LOC84167 [Homo sapiens]
Length = 657
Score = 44.7 bits (104), Expect = 2e-04
Identities = 68/291 (23%), Positives = 111/291 (38%), Gaps = 47/291 (16%)
Query: 8 ALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSI 67
A P S A PS H D+ + R ++ ++ TA PS + +
Sbjct: 260 AFTVPSVELSSAKPSQTSHLPTSLAADRTLHSTRSRADYPQSHVSSDTASHTPSVSITGA 319
Query: 68 FSQATNGVAEQNGH----STPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQAN 123
FS N V+ + GH S+PG++ A + ADD +++
Sbjct: 320 FS---NSVSLKMGHVKLVSSPGRS--EAETVDEPVSEGADDSLDEF-------------- 360
Query: 124 NVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMA 183
+ DG ++E EQ E Q +T+G+I R + Q RQ R
Sbjct: 361 RINILSLDGLAPAVSENSDLEQEEESAQRQ---KTAGKI-FRAEASTGQDAPRQAQARSW 416
Query: 184 GQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSV-PSDQSPSVQ- 241
+ AS + D E SE ++ + ++Q DS SS+ P ++P V
Sbjct: 417 ASQGKAASAEGD-------ESEVSEHLS------ASSASAIQQDSTSSMQPPSEAPMVNT 463
Query: 242 IDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDL 292
+ S S + PS+ + + S E D L L++ +S +TDL
Sbjct: 464 VSSAYSEDFENSPSL-----TASEPTAHSKESLDRTLDALSESSSSVKTDL 509
Score = 30.8 bits (68), Expect = 3.3
Identities = 86/411 (20%), Positives = 150/411 (36%), Gaps = 64/411 (15%)
Query: 35 QKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQAGRRAS-- 92
Q+N ++ ++D+ TA + A R+ S + SQ T+ ++ P +
Sbjct: 110 QRNLSDTESDSMTADAGLPKRADRILSGGALELASQNTDKTSQNQARELPVTENNAQNAK 169
Query: 93 -------NPADVSDLRAD-----DQVNQTPSEQTKGKASSQANNVQHE------------ 128
A V ++ + ++ QTP ++ + ++ + E
Sbjct: 170 VSRFLKKKQAPVENISPEAPAGKERTLQTPKQKEPARTFDSPDSDEEEMKVLLGSLMDSS 229
Query: 129 QSDGQVSGLTEERTAEQTERRL---PTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQ 185
+ G + +E+ ER+L P+Q T ++ A PS QT H
Sbjct: 230 REKNTNQGFSSANVSEEEERKLFSVPSQLRAFTVPSVELSSAKPS------QTSHLPT-- 281
Query: 186 SERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSG 245
S DR + R Q +H S + PSV I S S S+++
Sbjct: 282 -----SLAADRTLHSTRSRADYPQ-SHVSSDTASHTPSVSITGAFS----NSVSLKMGHV 331
Query: 246 SSVPSDQRPSVQ-IDRRMSGKVRRRSSEKTDYR-----LAGLADPGTSEQTDLRLYGLVD 299
V S R + +D +S ++R L GLA P SE +DL +
Sbjct: 332 KLVSSPGRSEAETVDEPVS---EGADDSLDEFRINILSLDGLA-PAVSENSDLEQEE--E 385
Query: 300 HKTSVKTHHQVY-GQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKD 358
KT +++ +A+ + QA S A Q +A ES+ ++HL+ A+
Sbjct: 386 SAQRQKTAGKIFRAEASTGQDAPRQAQARSWASQGKAASAEGDESEVSEHLSASSASAIQ 445
Query: 359 QLSYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVE 409
Q S + SE P + D+ P S+ +SK S++
Sbjct: 446 QDSTSSMQPPSE---APMVNTVSSAYSEDFENSP-SLTASEPTAHSKESLD 492
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 44.3 bits (103), Expect = 3e-04
Identities = 78/418 (18%), Positives = 151/418 (36%), Gaps = 50/418 (11%)
Query: 1 MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVP 60
+E P E A+P + E P + + + E + +AE++A T A +T
Sbjct: 1874 VEAPEAEGEAQP-ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDE 1932
Query: 61 SQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASS 120
++E + +A E G + P ++V + + ++ Q SE + +
Sbjct: 1933 PESEGAEAQEAEEAAQEAEGQTQP---------ESEVIESQEAEEEAQPESEDVE----A 1979
Query: 121 QANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDH 180
V+ ++++G+ +E+ A + E + +AE + DG A P + Q
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEM-QEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038
Query: 181 RMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSV 240
++E A + D + EAE + E VQ G + P +
Sbjct: 2039 GETQKTEGDAQPESDGVEAPEAE-----------EEAQEAEGEVQEAEGEAHPESEDVDA 2087
Query: 241 QIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDH 300
Q G + P S V +E + G+ P T + G+
Sbjct: 2088 QEAEGEAQPE------------SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135
Query: 301 KTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQL 360
+ + + G + AE +A ++ A E + L +A +
Sbjct: 2136 EAEGEAQPESEGVEAQDAEGEAQPESEG-------IEAQEAEEEAQPELEGVEAPEAEGE 2188
Query: 361 SYYETRG----QSEDRIFPQL-GNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQ 413
+ E+ G ++E P+L G + E + + +P E + + ++P E ETQ
Sbjct: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
Score = 39.3 bits (90), Expect = 0.009
Identities = 53/268 (19%), Positives = 93/268 (34%), Gaps = 17/268 (6%)
Query: 3 EPPQEALAEPLKHESPAAPSSAG------HTKGQEEDDQKNQAERKADNHTAHRIADQTA 56
E QE E K E A P S G + QE + + +AE +A + A +
Sbjct: 2032 EEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE 2091
Query: 57 LRVPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKG 116
++E +A + G P G + A+ + +++G
Sbjct: 2092 GEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQP----ESEG 2147
Query: 117 KASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSR 176
+ A +S+G + EE + E +AE + +G A ++
Sbjct: 2148 VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQP 2207
Query: 177 QTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQ 236
+ + A ++E A + + + EAE + + P V + G S + +
Sbjct: 2208 ELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASE 2267
Query: 237 SPS-VQIDSGSSVPS------DQRPSVQ 257
S S V D + PS QRP Q
Sbjct: 2268 SSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
Score = 30.8 bits (68), Expect = 3.3
Identities = 37/191 (19%), Positives = 66/191 (34%), Gaps = 13/191 (6%)
Query: 29 GQEEDDQKNQAERKADNHT-----------AHRIADQTALRVPSQAESSIFSQATNGVAE 77
G+ E D Q ER+ H A + + + R + + S G A
Sbjct: 1761 GEAEGDAMAQ-EREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAA 1819
Query: 78 QNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGL 137
G PGQ+ A ++ A + + + +G A Q E D +
Sbjct: 1820 AGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEA 1879
Query: 138 TEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRR 197
E E + P +AE + +G A +++ +T+ A ++E + +
Sbjct: 1880 EGEAQPESEDVETP-EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGA 1938
Query: 198 MSGEAERRTSE 208
+ EAE E
Sbjct: 1939 EAQEAEEAAQE 1949
>gi|199559779 coiled-coil domain containing 8 [Homo sapiens]
Length = 538
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/219 (22%), Positives = 80/219 (36%), Gaps = 15/219 (6%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAES 65
+EA+A+ + E A AG Q + NQ E ADN A A++ A +Q E
Sbjct: 305 EEAIAD--QREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREE 362
Query: 66 SIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNV 125
+ +Q A+Q T + AD+Q + P++Q +Q
Sbjct: 363 AADNQRAEAPADQRSQGTDNH-----------REEAADNQRAEAPADQGSEVTDNQREEA 411
Query: 126 QHEQSD--GQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMA 183
H+Q + V G +R + +R +R + + Q + A
Sbjct: 412 VHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARA 471
Query: 184 GQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRP 222
+ + Q R S +RR + T RL L +R P
Sbjct: 472 RKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVP 510
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/166 (22%), Positives = 62/166 (37%), Gaps = 8/166 (4%)
Query: 29 GQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQ-A 87
GQ D + +Q AD+ IADQ +Q + Q Q + Q A
Sbjct: 286 GQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRA 345
Query: 88 GRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTE 147
G A A+ +D + ++ + +E + S +N + E +D Q + ++ +E T+
Sbjct: 346 GAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTD 405
Query: 148 RRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQ 193
+R D R P+ Q Q AGQ A Q
Sbjct: 406 -------NQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQ 444
Score = 35.8 bits (81), Expect = 0.10
Identities = 44/221 (19%), Positives = 79/221 (35%), Gaps = 18/221 (8%)
Query: 60 PSQAESSIFSQATN--GVAEQNGHSTPGQAGRRASNPADV-----SDLRADDQVNQTPSE 112
P E+ + S A GV+ ++PG R N DV S R ++N
Sbjct: 219 PGVGEARLASTAVESAGVSSAPEGTSPGD---RLGNAGDVCVPQASPRRWRPKINWASFR 275
Query: 113 QTKGKASS---QANNVQHEQSDGQVSGLTEERTAEQTE-----RRLPTQAERRTSGQIDG 164
+ + + ++ Q +++ +Q EE A+Q E +R A++ +
Sbjct: 276 RRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQ 335
Query: 165 RLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSV 224
R +QR + +R ++R A++R+ HR +R
Sbjct: 336 REEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEA 395
Query: 225 QIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGK 265
D GS V +Q D P+ Q Q + +G+
Sbjct: 396 PADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQ 436
Score = 32.3 bits (72), Expect = 1.1
Identities = 29/179 (16%), Positives = 54/179 (30%), Gaps = 1/179 (0%)
Query: 169 PSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDS 228
P+ Q + D +R D+R +R +R +
Sbjct: 284 PTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQ 343
Query: 229 GSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSE 288
+ P+++ + +QR D+R G R + R AD G+
Sbjct: 344 RAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEV 403
Query: 289 QTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAIDQAHS-NADQPPVDNAHYTESDQT 346
+ R + D + Q + Q + AH+ A P + A + + T
Sbjct: 404 TDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGT 462
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/158 (24%), Positives = 71/158 (44%), Gaps = 9/158 (5%)
Query: 76 AEQNGHSTPGQAGRRAS--NPADVSDLRAD----DQVNQTPSEQTKGKASSQANNV-QHE 128
+E+ P Q G +S N S LR D Q N+ SE + + Q + + E
Sbjct: 326 SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQE 385
Query: 129 QSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSER 188
+ Q+ ++R +Q E+R + ++R + + R +QR Q + R + ER
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRR--EREARRQQEREQRRREQEEKRRLEELER 443
Query: 189 RASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQI 226
R E+ +RR + E +RR + + +L E + +++
Sbjct: 444 RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/158 (24%), Positives = 71/158 (44%), Gaps = 9/158 (5%)
Query: 76 AEQNGHSTPGQAGRRAS--NPADVSDLRAD----DQVNQTPSEQTKGKASSQANNV-QHE 128
+E+ P Q G +S N S LR D Q N+ SE + + Q + + E
Sbjct: 326 SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQE 385
Query: 129 QSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSER 188
+ Q+ ++R +Q E+R + ++R + + R +QR Q + R + ER
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRR--EREARRQQEREQRRREQEEKRRLEELER 443
Query: 189 RASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQI 226
R E+ +RR + E +RR + + +L E + +++
Sbjct: 444 RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/158 (24%), Positives = 71/158 (44%), Gaps = 9/158 (5%)
Query: 76 AEQNGHSTPGQAGRRAS--NPADVSDLRAD----DQVNQTPSEQTKGKASSQANNV-QHE 128
+E+ P Q G +S N S LR D Q N+ SE + + Q + + E
Sbjct: 326 SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQE 385
Query: 129 QSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSER 188
+ Q+ ++R +Q E+R + ++R + + R +QR Q + R + ER
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRR--EREARRQQEREQRRREQEEKRRLEELER 443
Query: 189 RASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQI 226
R E+ +RR + E +RR + + +L E + +++
Sbjct: 444 RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 43.1 bits (100), Expect = 6e-04
Identities = 43/173 (24%), Positives = 73/173 (42%), Gaps = 12/173 (6%)
Query: 103 DDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQI 162
D+++ + E+ + + + + E+ + E+ A ERR +++ R S +
Sbjct: 244 DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRT 303
Query: 163 DGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRP 222
SD+R SR DH+ + ERR S DRR S +R + HR S+ +RR
Sbjct: 304 -------SDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR---SERKHR-SRSRDRRR 352
Query: 223 SVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTD 275
S D S +S + D S ++R S + R + SE T+
Sbjct: 353 SKSRDRKSYKHRSKSRDREQDR-KSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Score = 32.0 bits (71), Expect = 1.5
Identities = 34/181 (18%), Positives = 65/181 (35%), Gaps = 8/181 (4%)
Query: 112 EQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSD 171
E+ K K + ++ + EER E+ R + +RR + +
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE-------ERE 280
Query: 172 QRGSRQTDHRMAGQSE-RRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGS 230
+ +R + R +S R +S DRR S + + S R S+ +RR S D
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 231 SVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQT 290
+S + S + S DR K + + +D + + + +Q+
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 291 D 291
+
Sbjct: 401 E 401
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 43.1 bits (100), Expect = 6e-04
Identities = 43/173 (24%), Positives = 73/173 (42%), Gaps = 12/173 (6%)
Query: 103 DDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQI 162
D+++ + E+ + + + + E+ + E+ A ERR +++ R S +
Sbjct: 244 DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRT 303
Query: 163 DGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRP 222
SD+R SR DH+ + ERR S DRR S +R + HR S+ +RR
Sbjct: 304 -------SDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR---SERKHR-SRSRDRRR 352
Query: 223 SVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTD 275
S D S +S + D S ++R S + R + SE T+
Sbjct: 353 SKSRDRKSYKHRSKSRDREQDR-KSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Score = 32.0 bits (71), Expect = 1.5
Identities = 34/181 (18%), Positives = 65/181 (35%), Gaps = 8/181 (4%)
Query: 112 EQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSD 171
E+ K K + ++ + EER E+ R + +RR + +
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE-------ERE 280
Query: 172 QRGSRQTDHRMAGQSE-RRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGS 230
+ +R + R +S R +S DRR S + + S R S+ +RR S D
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 231 SVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQT 290
+S + S + S DR K + + +D + + + +Q+
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 291 D 291
+
Sbjct: 401 E 401
>gi|56606114 trichohyalin-like 1 [Homo sapiens]
Length = 904
Score = 43.1 bits (100), Expect = 6e-04
Identities = 89/465 (19%), Positives = 176/465 (37%), Gaps = 57/465 (12%)
Query: 1 MEEPPQEALAEPLKHES--PAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALR 58
++EPP + EP + P ++ ++ Q+ D K+ R D + ADQT +
Sbjct: 288 IQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVC-RMFDTQEPGKDADQTPAK 346
Query: 59 VPSQAESSIFSQATNGVAEQ-NGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQ-TKG 116
+ E + + + ++ P Q G R N ++ SD+R + + + P T G
Sbjct: 347 TKNLGEPEDYGRTSETQEKECETKDLPVQYGSR--NGSETSDMRDERKERRGPEAHGTAG 404
Query: 117 KASSQANN----VQHEQSDG---QVSGLTEERTAEQTERR--LPTQAERRTSGQIDGRLA 167
+ ++ + DG ++ GL++ + AE+ L ++ +T +++G
Sbjct: 405 QKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAV 464
Query: 168 MPSDQRGSRQ------TDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERR 221
+ +++ + + A +ER + + E+++ + T R++K ++
Sbjct: 465 SGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENT-RVTKTHDQ- 522
Query: 222 PSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPS-------------VQIDRRMSGKVRR 268
V+ + G +SP Q D GSS + S VQ D + G
Sbjct: 523 -PVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHG 581
Query: 269 RSSEKTDYRLAGLADPGTSEQTDLRLYGLV------------DHKTSVKTHHQVYGQATE 316
S + GT + + L +V D + + H+ G T+
Sbjct: 582 ESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTK 641
Query: 317 LAEHQAIDQAHSNADQPPV--DNAHYTESDQTDHLADRQANHKDQLSYYET--RGQSEDR 372
H A + +N E + T L + + DQLS + +G S +
Sbjct: 642 GPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDE---DFTDQLSLMQLPGKGDSRNE 698
Query: 373 IFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATT 417
+ Q +SKE+K Q E D ++ +++ET+ T
Sbjct: 699 LKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVT 743
>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
Length = 330
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/195 (19%), Positives = 91/195 (46%), Gaps = 18/195 (9%)
Query: 27 TKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQ 86
++G+EED+ ++ ++ K D AD + + + E + +N + S+ +
Sbjct: 153 SEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSR 212
Query: 87 AGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQT 146
+ R+S+P+ S R+ + + S Q++ ++SS+ + +S G ++ R++ ++
Sbjct: 213 SSSRSSSPSS-SRSRSRSRSRSSSSSQSRSRSSSR----ERSRSRG-----SKSRSSSRS 262
Query: 147 ERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRT 206
R + +R S + S +R +++ R + +R+ ++ R S E R+
Sbjct: 263 HRGSSSPRKRSYSS------SSSSPERNRKRSRSRSSSSGDRK--KRRTRSRSPERRHRS 314
Query: 207 SEQITHRLSKLSERR 221
S +H S+ S ++
Sbjct: 315 SSGSSHSGSRSSSKK 329
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 42.0 bits (97), Expect = 0.001
Identities = 85/409 (20%), Positives = 137/409 (33%), Gaps = 62/409 (15%)
Query: 15 HESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESS-IFSQATN 73
H+S SS E D ++QA R + H D+ R Q SS I Q N
Sbjct: 593 HDSWETRSSYPERDRYPERDNRDQA-RDSSFERRHGERDRRDNRERDQRPSSPIRHQGRN 651
Query: 74 GVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQ 133
E++ RR D D R D++ + E+ + + + + ++ +
Sbjct: 652 DELERDE--------RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREK 703
Query: 134 VSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQ 193
L ER E+ R + ER D+ R DH + ER +
Sbjct: 704 ERELERERARERERER---EKER--------------DRERDRDRDHDRERERERERDRE 746
Query: 194 MDR-RMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQ 252
+R R E ER + + ER + + D D D G ++
Sbjct: 747 KEREREREERERERERERERERERERERERARERDKERERQRDWEDK---DKGRDDRREK 803
Query: 253 RPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTS------EQTDLRLYGLVDHKTSVKT 306
R ++ DR R S+K YR G P S D Y D K
Sbjct: 804 REEIREDRNPRDGHDERKSKKR-YRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNE--- 859
Query: 307 HHQVYGQATELAEHQAIDQAHSNAD------------QPPVDNAHYTESDQTDHLA--DR 352
H++ Q E +++ +H D + + Y E + + ++ D+
Sbjct: 860 KHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDK 919
Query: 353 QANHKDQLSYYETRG-------QSEDRIFPQLGNSKEDKEADYRVQPCK 394
Q + L R QSEDR + + K+A + +P K
Sbjct: 920 QREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIK 968
Score = 29.3 bits (64), Expect = 9.5
Identities = 56/299 (18%), Positives = 110/299 (36%), Gaps = 30/299 (10%)
Query: 5 PQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAE 64
P +L+ P + +SP S KG+ + ++ +Q+ + H R E
Sbjct: 375 PSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDR--RHERREDTRGKRDREKDSRE 432
Query: 65 SSIFSQATNGVAEQNGHSTP--GQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQA 122
+ Q + + P G+ R A + D +LR + + + + + ++
Sbjct: 433 EREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKES 492
Query: 123 NNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRM 182
+ + +S +R T R+ T E S GR + + S +T+ R
Sbjct: 493 RDPRDSRSTRDAHDY-RDREGRDTHRKEDTYPEESRS---YGRNHLREE---SSRTEIRN 545
Query: 183 AGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQI 242
++E R+ + DR R+ ++ K S QIDS S S+ +
Sbjct: 546 ESRNESRSEIRNDRM------GRSRGRVPELPEKGSRGSRGSQIDSHS---SNSNYHDSW 596
Query: 243 DSGSSVPS----------DQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTD 291
++ SS P DQ +RR + RR + E+ + + G +++ +
Sbjct: 597 ETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELE 655
Score = 29.3 bits (64), Expect = 9.5
Identities = 30/134 (22%), Positives = 52/134 (38%), Gaps = 14/134 (10%)
Query: 101 RADDQVNQTPSEQTKGKASSQ-----ANNVQHEQSDGQVSGLTEERTAEQTER------- 148
R+ +V + P + ++G SQ +N+ H+ + + S +R E+ R
Sbjct: 562 RSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSS 621
Query: 149 --RLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRT 206
R + +RR + + D R + P +G R + ERR DRR ER
Sbjct: 622 FERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDR 681
Query: 207 SEQITHRLSKLSER 220
+ + ER
Sbjct: 682 ERERDRERERERER 695
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 41.6 bits (96), Expect = 0.002
Identities = 41/201 (20%), Positives = 73/201 (36%), Gaps = 19/201 (9%)
Query: 27 TKGQEEDDQKNQAERKADNHTAHRIAD---QTALRVPSQAESSIFSQATNGVAEQNGHST 83
T+ + + D+K ER+ +R D QT + + E +Q G
Sbjct: 88 TEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDRERE------------KQKGRER 135
Query: 84 PGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTA 143
GR D R + Q + Q + + + + + +Q + + + +
Sbjct: 136 ERDRGRERERDRDREKER-ERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRD 194
Query: 144 EQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAE 203
+ ER T ER + +D+ G R+TD R Q +R ++ DR + E
Sbjct: 195 TEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEE 254
Query: 204 R---RTSEQITHRLSKLSERR 221
R R E+ R K E +
Sbjct: 255 RKKERKKERKKERKEKKKEEK 275
Score = 32.3 bits (72), Expect = 1.1
Identities = 33/174 (18%), Positives = 62/174 (35%), Gaps = 11/174 (6%)
Query: 104 DQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQID 163
D+ + E+ + + + N + +Q++ + E++ + ER + ER
Sbjct: 93 DRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRD---- 148
Query: 164 GRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPS 223
++ RQT+ GQ E + DR + ER T + ER
Sbjct: 149 ------REKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQ 202
Query: 224 VQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYR 277
+ + + D +D+R Q DR GK R R ++ + R
Sbjct: 203 TDRERDRQRKTQTERQRETDREGERETDRRRERQRDRD-RGKERDRERDRKEER 255
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/210 (17%), Positives = 88/210 (41%), Gaps = 14/210 (6%)
Query: 2 EEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPS 61
+ P+ +A+ + E A S+ + DD+ + +++ D+
Sbjct: 1226 DNDPENRIAKKMLLEEIKANLSSD--EDGSSDDEPEEGKKRTGKQNEENPGDE------- 1276
Query: 62 QAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSE--QTKGKAS 119
+A++ + S++ + E P R + VSD + ++ P E + KG+
Sbjct: 1277 EAKNQVNSESDSDSEESK---KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1333
Query: 120 SQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTD 179
+ ++ E SD Q SG++EE + + E+R T++ ++ + + R +R +
Sbjct: 1334 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQ 1393
Query: 180 HRMAGQSERRASEQMDRRMSGEAERRTSEQ 209
+ +++ + E+ + + E E E+
Sbjct: 1394 EDSSSENKSNSEEEEEEKEEEEEEEEEEEE 1423
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/257 (14%), Positives = 98/257 (38%), Gaps = 12/257 (4%)
Query: 1 MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALR-- 58
++E + +L K + SS+ + E+DDQ + E +D + + L
Sbjct: 1143 VKEKKRNSLRTSTKRKQADITSSS--SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1200
Query: 59 ---VPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTK 115
S + ++ V + + + P + ++ + D+ + E +
Sbjct: 1201 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 116 GKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGS 175
GK + N ++ + + + E ++ E + P R ++ +++ +
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1320
Query: 176 RQTDHR-MAGQSERRA----SEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGS 230
+ +H+ + G++ R+ SE D + SG +E + + R S ++ ++ + S
Sbjct: 1321 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS 1380
Query: 231 SVPSDQSPSVQIDSGSS 247
+ +++ SS
Sbjct: 1381 YKQKKKRRRIKVQEDSS 1397
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/210 (17%), Positives = 88/210 (41%), Gaps = 14/210 (6%)
Query: 2 EEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPS 61
+ P+ +A+ + E A S+ + DD+ + +++ D+
Sbjct: 1264 DNDPENRIAKKMLLEEIKANLSSD--EDGSSDDEPEEGKKRTGKQNEENPGDE------- 1314
Query: 62 QAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSE--QTKGKAS 119
+A++ + S++ + E P R + VSD + ++ P E + KG+
Sbjct: 1315 EAKNQVNSESDSDSEESK---KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1371
Query: 120 SQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTD 179
+ ++ E SD Q SG++EE + + E+R T++ ++ + + R +R +
Sbjct: 1372 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQ 1431
Query: 180 HRMAGQSERRASEQMDRRMSGEAERRTSEQ 209
+ +++ + E+ + + E E E+
Sbjct: 1432 EDSSSENKSNSEEEEEEKEEEEEEEEEEEE 1461
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/257 (14%), Positives = 98/257 (38%), Gaps = 12/257 (4%)
Query: 1 MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALR-- 58
++E + +L K + SS+ + E+DDQ + E +D + + L
Sbjct: 1181 VKEKKRNSLRTSTKRKQADITSSS--SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1238
Query: 59 ---VPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTK 115
S + ++ V + + + P + ++ + D+ + E +
Sbjct: 1239 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 116 GKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGS 175
GK + N ++ + + + E ++ E + P R ++ +++ +
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1358
Query: 176 RQTDHR-MAGQSERRA----SEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGS 230
+ +H+ + G++ R+ SE D + SG +E + + R S ++ ++ + S
Sbjct: 1359 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS 1418
Query: 231 SVPSDQSPSVQIDSGSS 247
+ +++ SS
Sbjct: 1419 YKQKKKRRRIKVQEDSS 1435
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 40.8 bits (94), Expect = 0.003
Identities = 72/426 (16%), Positives = 163/426 (38%), Gaps = 60/426 (14%)
Query: 14 KHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAH--RIADQTALRVPSQAESSIFSQA 71
K E+ A G K E+ D+++ E + D + + ++ + AL +P + ++ S+
Sbjct: 4834 KEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPD--DLNLDSED 4891
Query: 72 TNGVAEQNGHS-----------TPGQAGR----RASNPADVSDLRADDQVNQTPSEQTKG 116
NG + + P +AG R D ++ ++ + + PSE K
Sbjct: 4892 KNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKA 4951
Query: 117 KASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSR 176
+ + + +Q DG + EE + EQ + E G +G P+DQ
Sbjct: 4952 EGEEEMDTGADDQ-DGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENG----PADQGFQP 5006
Query: 177 QTDH-RMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSD 235
Q + R +E + E ++R+ + E + + + ++ + P
Sbjct: 5007 QEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQN----------TQAMELAGAAPEK 5056
Query: 236 QSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLY 295
+ + SG++ + Q + S + + +S+K + + Q+ R
Sbjct: 5057 EQGKEEHGSGAA------DANQAEGHESNFIAQLASQKHTRK---------NTQSFKRKP 5101
Query: 296 GLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVD--NAHYTESDQTDHLADRQ 353
G D++ S+ H++ + + S+A+Q P A ++D +H+ +Q
Sbjct: 5102 GQADNERSMGDHNERVHKRLRTVD------TDSHAEQGPAQQPQAQVEDADAFEHI--KQ 5153
Query: 354 ANHKDQLSYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQ 413
+ Y+ + + + G +E++E + + + ++ + + E +
Sbjct: 5154 GSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIK 5213
Query: 414 NATTIP 419
+ TT P
Sbjct: 5214 SGTTAP 5219
Score = 30.0 bits (66), Expect = 5.5
Identities = 67/350 (19%), Positives = 124/350 (35%), Gaps = 42/350 (12%)
Query: 25 GHTKGQEEDDQKNQAE-RKADNHTAH---RIADQTALRVPSQAESSIFSQATNGVAEQNG 80
G + QEEDD+K+ +E D H AD+ R+ + + + E+ G
Sbjct: 4740 GELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETG 4799
Query: 81 HSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEE 140
PG + A +L + + N+ S+Q K + +A Q + +++ +E
Sbjct: 4800 ---PGMDEEDSELVAKDDNLDSGNS-NKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDE 4855
Query: 141 RTAEQTE--------RRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASE 192
R ++ E ++P E D D+ G TD+ + +
Sbjct: 4856 RDYDENEVDPYHGNQEKVP---EPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIK 4912
Query: 193 QMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGS---SVP 249
+ EAE R E T + S + P + G S ++D+G+
Sbjct: 4913 EKPEEAGHEAEER-GETETDQNESQSPQEP----EEGPSEDDKAEGEEEMDTGADDQDGD 4967
Query: 250 SDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQ 309
+ Q P + + + + G AD G Q + + + T Q
Sbjct: 4968 AAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE-------EEREDSDTEEQ 5020
Query: 310 VYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQ 359
V +A E E H++ Q V+N T++ + A + K++
Sbjct: 5021 V-PEALERKE-------HASCGQTGVENMQNTQAMELAGAAPEKEQGKEE 5062
>gi|115430241 SCY1-like 1 isoform A [Homo sapiens]
Length = 808
Score = 40.0 bits (92), Expect = 0.005
Identities = 30/88 (34%), Positives = 44/88 (50%), Gaps = 13/88 (14%)
Query: 2 EEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPS 61
+ P E + P PA P+++GH + QEED K+ AE D+ TA R D+ +
Sbjct: 600 QRPTPEGVPAPAPTPVPATPTTSGHWETQEED--KDTAE---DSSTADRWDDEDWGSLEQ 654
Query: 62 QAESSIFSQATNGVAEQNGHSTPGQAGR 89
+AES + A+Q+ ST GQ R
Sbjct: 655 EAESVL--------AQQDDWSTGGQVSR 674
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 7/123 (5%)
Query: 110 PSEQTKGKASSQANNVQHEQSDGQ--VSGLTEERTAEQTER-----RLPTQAERRTSGQI 162
P E T A+ + V + Q +S E + + ER R T+++ R+S +
Sbjct: 263 PPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKS 322
Query: 163 DGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRP 222
R + SR + + Q +RR S+ ++ S ERR S +H K + R
Sbjct: 323 HSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE 382
Query: 223 SVQ 225
++
Sbjct: 383 KIK 385
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 7/123 (5%)
Query: 110 PSEQTKGKASSQANNVQHEQSDGQ--VSGLTEERTAEQTER-----RLPTQAERRTSGQI 162
P E T A+ + V + Q +S E + + ER R T+++ R+S +
Sbjct: 147 PPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKS 206
Query: 163 DGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRP 222
R + SR + + Q +RR S+ ++ S ERR S +H K + R
Sbjct: 207 HSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE 266
Query: 223 SVQ 225
++
Sbjct: 267 KIK 269
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 40.0 bits (92), Expect = 0.005
Identities = 58/325 (17%), Positives = 119/325 (36%), Gaps = 45/325 (13%)
Query: 4 PPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQA 63
PP A+ P K E P + Q+ + + +R + T++ ++ L+ +
Sbjct: 329 PPLTAIHTPCKTEPSKFPFPT--KESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKL 386
Query: 64 ESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKAS-SQA 122
SS S + STPG + + ++ +D DD + + SE + G S S++
Sbjct: 387 SSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESES 446
Query: 123 NNVQHEQSDGQVSGLTEER----------------------TAEQTERRLPTQAERRTSG 160
++ E ++ S E A + +P+ + G
Sbjct: 447 SSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEG 506
Query: 161 QIDGRLAMPSDQRGSRQTDHRMAGQSER---------RASEQMDRRMSGEAERRT-SEQI 210
+ G +D G ++T G+ + R ++ + +RRT ++
Sbjct: 507 REQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ 566
Query: 211 THRLSKLSERRP--------SVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRM 262
+ K + P +D SS+PS + + GS P+ ++ S R
Sbjct: 567 PKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAA--TKGSRKPNIKKESKSSPRPT 624
Query: 263 SGKVRRRSSEKTDYRLAGLADPGTS 287
+ K + +S+ K+ + + + TS
Sbjct: 625 AEKKKYKSTSKSSQKSREIIETDTS 649
Score = 29.6 bits (65), Expect = 7.2
Identities = 27/145 (18%), Positives = 58/145 (40%), Gaps = 9/145 (6%)
Query: 112 EQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGR----LA 167
+Q K S++ + D + S + +T ++ + R +S Q + L
Sbjct: 754 KQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLP 813
Query: 168 MPSDQRGSR--QTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQ 225
P+ S+ +T+H G +R S+ + S + + TS + S +++ +
Sbjct: 814 SPAGPVPSKDPKTEH---GSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGK 870
Query: 226 IDSGSSVPSDQSPSVQIDSGSSVPS 250
S S +++PS + S P+
Sbjct: 871 TSSSSKEVKEKAPSSSSNCPPSAPT 895
>gi|112821681 G protein-regulated inducer of neurite outgrowth 1
[Homo sapiens]
Length = 1008
Score = 40.0 bits (92), Expect = 0.005
Identities = 57/260 (21%), Positives = 100/260 (38%), Gaps = 31/260 (11%)
Query: 78 QNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGL 137
++ H +P AG AS SD +P+ + ++ S+ H S +SG
Sbjct: 68 ESRHRSPSGAGEGAS----CSDGPRGSLACPSPTCFSPQESPSKETLEAHGAS---ISGT 120
Query: 138 TEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRR 197
E T+ + E + E ++S + D + S+Q D G+ + +S + D
Sbjct: 121 PEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPM 180
Query: 198 MSGEAE----RRTSEQITHRLSKLSERRPSV--------------------QIDSGSSVP 233
+G+AE + R+ ++ R+ + + D GS
Sbjct: 181 FTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRK 240
Query: 234 SDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLR 293
D S ++D + R S + S KV S+EK D L+G DPG S + D
Sbjct: 241 VDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPM 300
Query: 294 LYGLVDHKTSVKTHHQVYGQ 313
+D ++ KT + G+
Sbjct: 301 PLESMDSASTGKTEPGLLGK 320
Score = 34.3 bits (77), Expect = 0.29
Identities = 56/263 (21%), Positives = 102/263 (38%), Gaps = 19/263 (7%)
Query: 21 PSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGV----- 75
P SAG K E + N N + D +L + AT G
Sbjct: 466 PISAGSRKTSSE--KVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLS 523
Query: 76 AEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVS 135
+E+ G G+A AS A+ + +D V+ KGKA + + S G+V
Sbjct: 524 SEKAGLVASGKAAPTASGKAEPLAVGKEDPVS-------KGKADAGPSGQGDSVSIGKVV 576
Query: 136 GLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQT----DHRMAGQSERRAS 191
T +T ++ + + +G++ ++GS T D R +G+++ ++
Sbjct: 577 S-TPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSG 635
Query: 192 EQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSD 251
+ + ++ G+ + K + S ++D GS ++ S + + S +D
Sbjct: 636 GKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKAD 695
Query: 252 QRPSVQIDRRMSGKVRRRSSEKT 274
PS + + GKV S EKT
Sbjct: 696 SAPSRKTESPSLGKVVPLSLEKT 718
Score = 32.0 bits (71), Expect = 1.5
Identities = 73/370 (19%), Positives = 137/370 (37%), Gaps = 39/370 (10%)
Query: 8 ALAEPLKHESPAAPSSAGHTKGQEED-DQKNQAERKADNHTAHRIADQTALRVPSQAESS 66
A+ + + A+P+ HT Q + ++++ A + + +L PS S
Sbjct: 41 AMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFS 100
Query: 67 IFSQATNGVAEQNGHSTPGQAGRRASN-PADVSDLRAD----DQVNQTPSEQTKGKASSQ 121
+ E +G S G S P VS ++ + D N E+ K+S Q
Sbjct: 101 PQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQ 160
Query: 122 ANNV--------QHEQSDGQVSGLTEERTAEQTERRLPTQAERRT--------SGQIDGR 165
A++ ++D +G E + + P + + T G++D
Sbjct: 161 ADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPL 220
Query: 166 LAMPSDQRGSRQTDHRMAGQSERRASEQMD--------RRMSGEAERRTSEQITHRLSKL 217
+ + R+ D + + +S+++D R SG+ +SE++ ++
Sbjct: 221 CSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEK 280
Query: 218 SERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYR 277
+ S + D G S +D P +DS S+ ++ + GK+ SS K
Sbjct: 281 VDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEP--------GLLGKLIPGSSGKNGPV 332
Query: 278 LAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDN 337
+G PG+ + D G+ D SV V + +D A S +P +
Sbjct: 333 SSGTGAPGSLGRLDPTCLGMAD-PASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGH 391
Query: 338 AHYTESDQTD 347
T S +TD
Sbjct: 392 TDTTASAKTD 401
Score = 31.2 bits (69), Expect = 2.5
Identities = 48/218 (22%), Positives = 84/218 (38%), Gaps = 25/218 (11%)
Query: 85 GQAGRRASNPADVSDLRADDQVN----QTPSEQTKGKASSQANNVQHEQSDGQVSGLTEE 140
G+AG + D R +D ++ +T SE+ ++S + N V D + G
Sbjct: 446 GKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGP 505
Query: 141 RTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSG 200
+A +AE T G+ D + + S + +G++E A + D G
Sbjct: 506 PSA--------VKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKG 557
Query: 201 EAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSP--SVQIDSGSSVPSDQRPSVQI 258
+A+ S Q SV I S P P S ++D S ++ P ++
Sbjct: 558 KADAGPSGQ-----------GDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKV 606
Query: 259 DRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYG 296
K ++ K D R +G A P + + + +L G
Sbjct: 607 GSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPG 644
Score = 29.3 bits (64), Expect = 9.5
Identities = 74/394 (18%), Positives = 141/394 (35%), Gaps = 48/394 (12%)
Query: 2 EEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPS 61
E P +E L H + + + T G+ E + E K+ + ++ +
Sbjct: 103 ESPSKETLEA---HGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSK 159
Query: 62 QAESSIFSQATNGVAEQNGHSTPGQAGRRASNPAD-VSDLRADDQVNQTPSEQTKGKA-- 118
QA+S+ + G + + G+A D V+ R D + + GK
Sbjct: 160 QADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDP 219
Query: 119 --SSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQ---IDGRLAMPSDQR 173
SS+ V + D + ++++ + P + E R SG+ + P+
Sbjct: 220 LCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAE 279
Query: 174 G-----SRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDS 228
S + D +G+++ E MD +G+ E ++ S + P + S
Sbjct: 280 KVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSS--GKNGP---VSS 334
Query: 229 GSSVP-------------SDQSPSVQIDSGSSVPSDQRPSVQID-------RRMSGKVRR 268
G+ P +D + +++ + D R ++D R +SG
Sbjct: 335 GTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDT 394
Query: 269 RSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQA------ 322
+S KTD DP +S + D G +D S K GQA ++ +A
Sbjct: 395 TASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPG 454
Query: 323 -IDQAHSNADQPPVDNAHYTESDQTDHLADRQAN 355
D S + P + T S++ + + + N
Sbjct: 455 KEDPVSSRREDPISAGSRKTSSEKVNPESSGKTN 488
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 39.7 bits (91), Expect = 0.007
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 7/143 (4%)
Query: 83 TPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQS---DGQVSGLTE 139
T GQ R A+ R D+ Q +E+ + K + N Q + + TE
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTE 202
Query: 140 ERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSER-RASEQMDRRM 198
+R +E+ R + ER T + + + ++ R+T+ Q+ER RASE+ R
Sbjct: 203 DRHSERGRER---ERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERD 259
Query: 199 SGEAERRTSEQITHRLSKLSERR 221
R ++ R K ER+
Sbjct: 260 KERERERDRDRDRDRRQKERERQ 282
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 126 QHEQSDGQVSGLTEERTAEQTERRLPTQAE------RRTSGQIDGRLAMPSDQRGSRQTD 179
+ Q+D + E+ Q ER T+ E R+T GQ + +++ RQTD
Sbjct: 105 RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD 164
Query: 180 HRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSER 220
Q+ER ++ +R + + ERR E+ + +K +R
Sbjct: 165 RERQRQTERNRQKEREREKNRQ-ERRERERQREKENKTEDR 204
Score = 32.7 bits (73), Expect = 0.86
Identities = 42/218 (19%), Positives = 77/218 (35%), Gaps = 27/218 (12%)
Query: 27 TKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQ-------- 78
T GQ E +++ AE++ + T QT + E Q Q
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTE 202
Query: 79 NGHSTPGQAGRRASNPADVSDL-----RADDQVNQTPSEQTKG----KASSQANNVQHEQ 129
+ HS G+ R ++ R D+ +T E+ K +AS + E+
Sbjct: 203 DRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER 262
Query: 130 SDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERR 189
+ +R ++ ER+ + +RRT D+ R+ + + + ER
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTE----------RDRETERKRERQRERERERE 312
Query: 190 ASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQID 227
+ + +R E ER + K ER+ Q +
Sbjct: 313 RNRKRERERERERERERQRETERDREKERERKRKRQTE 350
Score = 32.3 bits (72), Expect = 1.1
Identities = 38/181 (20%), Positives = 67/181 (37%), Gaps = 7/181 (3%)
Query: 101 RADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAE-QTERRLPTQAERRTS 159
R D+ Q +E+ + + + E+ + ER E + ER+ T+ +R
Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKE 340
Query: 160 GQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSE 219
+ + D+ +RQT Q+ER + +R ER E+ R + E
Sbjct: 341 RERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR-DRQKE 399
Query: 220 RRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLA 279
R + D +++ + D S +R + R K R R E+ R A
Sbjct: 400 RERQTEKDRDGQRETEKQREREKDRES-----ERGRERGREREKQKGRERDRERQTDRQA 454
Query: 280 G 280
G
Sbjct: 455 G 455
Score = 31.6 bits (70), Expect = 1.9
Identities = 26/116 (22%), Positives = 44/116 (37%), Gaps = 4/116 (3%)
Query: 94 PADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQ 153
P D S R Q ++P + G+A A+ E++ + R QTER +
Sbjct: 23 PLDFSRRRPGSQ--ESPRRRGLGQAHKDADGDDRERN--RQKERERRREKRQTERETDRK 78
Query: 154 AERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQ 209
ERR + +++ R+ + ER + +R E ER T +
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETERE 134
Score = 29.3 bits (64), Expect = 9.5
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Query: 139 EERTAEQTERRLPTQAERRTSGQIDG-RLAMPSDQRG-SRQTDHRMAGQSERRASEQMDR 196
E+ QT+R Q E+ + Q + R +RG RQTD + + +R A ++ +R
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161
Query: 197 RMSGEAERRT 206
+ E +R+T
Sbjct: 162 QTDRERQRQT 171
>gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo
sapiens]
Length = 1045
Score = 39.7 bits (91), Expect = 0.007
Identities = 68/346 (19%), Positives = 127/346 (36%), Gaps = 44/346 (12%)
Query: 30 QEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQAGR 89
Q DD N ++ +DN A R P E S S+ + T Q
Sbjct: 462 QTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQS 521
Query: 90 RASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERR 149
+S +DVS + V + KG S T ++ ++ +R
Sbjct: 522 YSSGDSDVSRCSSPHSVLGKDEQINKGHCDSS----------------TRIKSKKEEKRS 565
Query: 150 LPTQAERRTSGQIDG-RLAMPSDQR-----GSRQTDHRMAGQSERRASEQMDRRMSGEAE 203
+ R + + G R+ P + R SR +D R QS ++ R+ G+
Sbjct: 566 TSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSR--SQSRSGHDQKNHRKHHGKKR 623
Query: 204 RRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMS 263
++ + S+ RR + + S S +S ++ + S S+ S R S
Sbjct: 624 MKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDH------ 677
Query: 264 GKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAI 323
GK R RS + Y L + G+ + + Y + ++ ++ + +
Sbjct: 678 GKRRSRSRNRDRYYLRN--NYGSRYKWEYTYYSRNKDRDGYESSYR----------RRTL 725
Query: 324 DQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYETRGQS 369
+AH + + + S++T+ A ++ NH ++ YY R +S
Sbjct: 726 SRAHYSRQSSSPEFRVQSFSERTN--ARKKNNHSERKYYYYERHRS 769
>gi|47578107 delangin isoform B [Homo sapiens]
Length = 2697
Score = 39.7 bits (91), Expect = 0.007
Identities = 68/330 (20%), Positives = 128/330 (38%), Gaps = 43/330 (13%)
Query: 6 QEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAES 65
+ LAE +E+ + + K + + + + + ++ ++ T +++ + P Q E+
Sbjct: 617 ESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNEN 676
Query: 66 SIFSQATNGVAEQNGHS--------TPGQAGR-RASNPADVSDLRAD------------- 103
+ N + NG S TP Q G R P SD +
Sbjct: 677 RLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETP 736
Query: 104 DQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQID 163
Q ++ E K K + +H + + SG TE++ ++ +
Sbjct: 737 KQKGESRPETPKQKNEGRPETPKHRHDNRRDSG------KPSTEKKPEVSKHKQDTKSDS 790
Query: 164 GRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMS-GEAERRTSEQITHRLSKLSERRP 222
RL + ++ D R +S RR + + GE+ER +Q R+ + R
Sbjct: 791 PRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ--SRVRRPETLRS 848
Query: 223 SVQIDSGSSVPSDQSPSVQID---SGSSVPSDQRPS--VQIDRRMSGKVRRRSSEKTDYR 277
S + + G + SD S + +++ S S +RPS Q R S +V++ S K+
Sbjct: 849 SSRNEHG--IKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSD 906
Query: 278 LAGLADPGTSEQTDLRLYGLVDHKTSVKTH 307
G P + + D R G +K+ V T+
Sbjct: 907 KLGFKSP--TSKDDKRTEG---NKSKVDTN 931
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.123 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,370,117
Number of Sequences: 37866
Number of extensions: 901826
Number of successful extensions: 4099
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 259
Number of HSP's that attempted gapping in prelim test: 3532
Number of HSP's gapped (non-prelim): 586
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.