Search of human proteins with 227430289

Search of human proteins with 227430289

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
         (728 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ...  1528   0.0  
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ...  1446   0.0  
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H...  1406   0.0  
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1...   451   e-126
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ...   449   e-126
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi...   380   e-105
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi...   344   1e-94
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo...   149   1e-35
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor...   148   2e-35
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ...   143   5e-34
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ...   132   1e-30
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ...   130   4e-30
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo...   126   6e-29
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo...   122   9e-28
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo...   117   3e-26
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo...   106   7e-23
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho...    98   2e-20
gi|239755724 PREDICTED: hypothetical protein [Homo sapiens]            48   4e-05
gi|148727370 immediate early response 5-like [Homo sapiens]            44   7e-04
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    42   0.003
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       41   0.003
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       41   0.003
gi|47132519 Ras association and pleckstrin homology domains 1 is...    41   0.004
gi|46409434 hypothetical protein LOC388759 [Homo sapiens]              40   0.008
gi|126116581 retina and anterior neural fold homeobox [Homo sapi...    39   0.013
gi|239754489 PREDICTED: hypothetical protein [Homo sapiens]            38   0.038
gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo ...    38   0.038
gi|239508715 PREDICTED: hypothetical protein [Homo sapiens]            38   0.038
gi|65288071 tensin 3 [Homo sapiens]                                    38   0.038
gi|206597556 kelch domain containing 7B [Homo sapiens]                 38   0.038

>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
           [Homo sapiens]
          Length = 728

 Score = 1528 bits (3956), Expect = 0.0
 Identities = 728/728 (100%), Positives = 728/728 (100%)

Query: 1   MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM 60
           MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM
Sbjct: 1   MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM 60

Query: 61  EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEF 120
           EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEF
Sbjct: 61  EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEF 120

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 180
           FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN
Sbjct: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 180

Query: 181 SDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLR 240
           SDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLR
Sbjct: 181 SDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLR 240

Query: 241 GTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTY 300
           GTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTY
Sbjct: 241 GTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTY 300

Query: 301 SSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPM 360
           SSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPM
Sbjct: 301 SSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPM 360

Query: 361 YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAF 420
           YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAF
Sbjct: 361 YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAF 420

Query: 421 MDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCF 480
           MDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCF
Sbjct: 421 MDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCF 480

Query: 481 QESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSV 540
           QESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSV
Sbjct: 481 QESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSV 540

Query: 541 TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPS 600
           TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPS
Sbjct: 541 TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPS 600

Query: 601 VTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRG 660
           VTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRG
Sbjct: 601 VTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRG 660

Query: 661 AQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASS 720
           AQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASS
Sbjct: 661 AQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASS 720

Query: 721 STCPLGGP 728
           STCPLGGP
Sbjct: 721 STCPLGGP 728


>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
           [Homo sapiens]
          Length = 692

 Score = 1446 bits (3743), Expect = 0.0
 Identities = 688/689 (99%), Positives = 689/689 (100%)

Query: 40  MKGNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQ 99
           +KGNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQ
Sbjct: 4   IKGNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQ 63

Query: 100 PTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYW 159
           PTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYW
Sbjct: 64  PTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYW 123

Query: 160 QFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFD 219
           QFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFD
Sbjct: 124 QFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFD 183

Query: 220 LYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 279
           LYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK
Sbjct: 184 LYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 243

Query: 280 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIF 339
           DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIF
Sbjct: 244 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIF 303

Query: 340 ACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFI 399
           ACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFI
Sbjct: 304 ACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFI 363

Query: 400 PLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSD 459
           PLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSD
Sbjct: 364 PLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSD 423

Query: 460 VPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKL 519
           VPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKL
Sbjct: 424 VPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKL 483

Query: 520 QVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNG 579
           QVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNG
Sbjct: 484 QVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNG 543

Query: 580 VAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIM 639
           VAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIM
Sbjct: 544 VAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIM 603

Query: 640 FLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP 699
           FLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP
Sbjct: 604 FLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP 663

Query: 700 PPAYATLGPRPSPGGSAGASSSTCPLGGP 728
           PPAYATLGPRPSPGGSAGASSSTCPLGGP
Sbjct: 664 PPAYATLGPRPSPGGSAGASSSTCPLGGP 692


>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
           sapiens]
          Length = 669

 Score = 1406 bits (3639), Expect = 0.0
 Identities = 669/669 (100%), Positives = 669/669 (100%)

Query: 60  MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 119
           MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
Sbjct: 1   MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 60

Query: 120 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 179
           FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
Sbjct: 61  FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 120

Query: 180 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 239
           NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
Sbjct: 121 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 180

Query: 240 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 299
           RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
Sbjct: 181 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 240

Query: 300 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 359
           YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
Sbjct: 241 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 300

Query: 360 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 419
           MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
Sbjct: 301 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 360

Query: 420 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 479
           FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
Sbjct: 361 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 420

Query: 480 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 539
           FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
Sbjct: 421 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 480

Query: 540 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 599
           VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
Sbjct: 481 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 540

Query: 600 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 659
           SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
Sbjct: 541 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 600

Query: 660 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 719
           GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
Sbjct: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 660

Query: 720 SSTCPLGGP 728
           SSTCPLGGP
Sbjct: 661 SSTCPLGGP 669


>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
           [Homo sapiens]
          Length = 704

 Score =  451 bits (1160), Expect = e-126
 Identities = 242/657 (36%), Positives = 358/657 (54%), Gaps = 38/657 (5%)

Query: 26  LDPDPCSPQSTPGLMK---GNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKG 82
           L P   S ++  G  K   G  L  + P P+ P         L+     P Q      +G
Sbjct: 32  LPPQWLSTEAWTGEWKQPHGGALTSRSPGPVAP----QRPCHLKGWQHRPTQHNAACKQG 87

Query: 83  NKREEQGLGP-EPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHN 139
               +    P  P+AP  P  E  +E L+E   S+REL  FFC N TIHGAIRLVCS+ N
Sbjct: 88  QAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGN 147

Query: 140 RMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRY 199
           R+KT  W +L L     + WQ GLLF  ++  PV + ++++S++ + P VT+C  NP R 
Sbjct: 148 RLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRP 207

Query: 200 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 259
             +   LE LD    + +  LY  +        S+ R  L  T+P      R  PP H  
Sbjct: 208 SPVLRHLELLDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLD 254

Query: 260 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 319
           R  R     L  +  +V     ++GF+LCN    DCFY+ Y+SGV AV++WY FHY++IL
Sbjct: 255 REIR--LQRLSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDIL 307

Query: 320 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 379
           + LP           G+F+ +C ++ + C    +  FHHP YG+CYT +      +W + 
Sbjct: 308 ALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQ 362

Query: 380 MPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMR 439
            PGI +G+ L+LR EQ   +PLLST+ G RVMVHG++   F+    F++RPG E +IS+R
Sbjct: 363 RPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIR 422

Query: 440 KETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ 499
           ++ + RLG  YG CT  G  V VE L+ + YT+Q C+ SCFQ+ M++ C C Y  +P P 
Sbjct: 423 EDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPA 482

Query: 500 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQE 559
             EYC   +H +WG+C+Y+L  D  +  L C ++C +PC  ++++LS G SRWPS  S  
Sbjct: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542

Query: 560 WVFQMLSRQN-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWF 618
           W    L  Q   +  + +R+ +AK+NI ++ELNY++  E+P  ++  LLS +GS  SLWF
Sbjct: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602

Query: 619 GSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 673
           G+SVLS++E+ EL+ D   +  ++  RR R  +  W       GA  +    +  PP
Sbjct: 603 GASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 659


>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
           [Homo sapiens]
          Length = 638

 Score =  449 bits (1155), Expect = e-126
 Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)

Query: 91  GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 148
           GP P+AP  P  E  +E L+E   S+REL  FFC N TIHGAIRLVCS+ NR+KT  W +
Sbjct: 32  GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 90

Query: 149 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 208
           L L     + WQ GLLF  ++  PV + ++++S++ + P VT+C  NP R   +   LE 
Sbjct: 91  LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 150

Query: 209 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 268
           LD    + +  LY  +        S+ R  L  T+P      R  PP H  R  R     
Sbjct: 151 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 195

Query: 269 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 328
           L  +  +V     ++GF+LCN    DCFY+ Y+SGV AV++WY FHY++IL+ LP     
Sbjct: 196 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 250

Query: 329 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 388
                 G+F+ +C ++ + C    +  FHHP YG+CYT +      +W +  PGI +G+ 
Sbjct: 251 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 305

Query: 389 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 448
           L+LR EQ   +PLLST+ G RVMVHG++   F+    F++RPG E +IS+R++ + RLG 
Sbjct: 306 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 365

Query: 449 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 508
            YG CT  G  V VE L+ + YT+Q C+ SCFQ+ M++ C C Y  +P P   EYC   +
Sbjct: 366 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 425

Query: 509 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 568
           H +WG+C+Y+L  D  +  L C ++C +PC  ++++LS G SRWPS  S  W    L  Q
Sbjct: 426 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 485

Query: 569 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 627
              +  + +R+ +AK+NI ++ELNY++  E+P  ++  LLS +GS  SLWFG+SVLS++E
Sbjct: 486 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 545

Query: 628 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 673
           + EL+ D   +  ++  RR R  +  W       GA  +    +  PP
Sbjct: 546 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 593


>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
           sapiens]
          Length = 649

 Score =  380 bits (977), Expect = e-105
 Identities = 211/611 (34%), Positives = 331/611 (54%), Gaps = 24/611 (3%)

Query: 115 RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVS 174
           +EL  ++C NT  HG  R+V S+  R++   W    L    ++ WQ  LL   +  Y VS
Sbjct: 26  KELMRWYCLNTNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALLVFSF--YTVS 82

Query: 175 LNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKY---------SS 225
           ++I ++  KL FPAVTIC +NPY+Y  ++  L +L++ T + L  LY +          S
Sbjct: 83  VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAES 142

Query: 226 FTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWK--I 283
           + ++  G + R   R  L    Q  +         R R V  S+      V   + K  +
Sbjct: 143 WNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202

Query: 284 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRF 343
           GFQLC+ + SDC   T+SSG++A++EWY+ HY+NI++++P         +    +  C F
Sbjct: 203 GFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF 262

Query: 344 NQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLS 403
           + VSC+  N++ FHHPM+GNCYTFN++ N  +  +SM G   GL ++L   + ++ P L 
Sbjct: 263 DGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLV 322

Query: 404 TVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVE 463
           + TGA+V++H QDE  F++D G  +   + TSI M      +L   Y  CT++GSDVP+ 
Sbjct: 323 SSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIR 382

Query: 464 NLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDF 523
           N+Y + Y+ Q+C+HSCFQ  M+++CGCA    P P    YC+Y++H +W YCYY+L   F
Sbjct: 383 NIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAF 442

Query: 524 SSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN--GVA 581
             + LGC + C++ CS   + L+   ++WPSV S++W+  +L+      VN K N   +A
Sbjct: 443 VQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLA 502

Query: 582 KVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL 641
           K+ IF+K+LN ++  ESP+ ++  LLSN G Q  LW   SV+ V+E+ E+ F    I F 
Sbjct: 503 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF----IDFF 558

Query: 642 MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPP 701
            ++ R   R W   +    A + A     +P S       +L +    P  + AL  PP 
Sbjct: 559 SIIAR---RQWQKAKEW-WAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA 614

Query: 702 AYATLGPRPSP 712
               +   P P
Sbjct: 615 LGTQVPGTPPP 625


>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
           sapiens]
          Length = 640

 Score =  344 bits (883), Expect = 1e-94
 Identities = 198/624 (31%), Positives = 317/624 (50%), Gaps = 43/624 (6%)

Query: 113 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP 172
           +Y+EL  ++C+NT  HG  R++C      K A W +L L    ++ WQ+G+    Y S+ 
Sbjct: 21  TYKELLVWYCDNTNTHGPKRIICE--GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78

Query: 173 VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 232
           VS+++++    + FPAVTIC  +P++Y +IK  L++LD + E  L  +         ++ 
Sbjct: 79  VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERI-----LAPELSH 133

Query: 233 SRSRRDLRGTL-------------PHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 279
           + + R+L  ++             PH    L +    H    + S +  + + +      
Sbjct: 134 ANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAH------ 187

Query: 280 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN-FI 338
             K+  +LC+ N++ C ++ ++S   A+ EWY     NI +++P+    +E    G   I
Sbjct: 188 GCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQ-ELVEMSYPGEQMI 246

Query: 339 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 398
            AC F    CN  N++   +P YGNCY FN         S+ PG   GL L+L   Q D+
Sbjct: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306

Query: 399 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 458
           +P L++  G R+M+H Q    F+ D G     G ETSI +  + L R+G  Y  CT NGS
Sbjct: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366

Query: 459 DVPVENLYP---SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYC 515
           +VPV+N Y    + Y+ Q C+ SCFQ+ MI+ C C +  YP P+  +YC+ R    W +C
Sbjct: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426

Query: 516 YYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN- 574
           Y  LQ+  +     C   C++ C+ T Y+++   + WPS  S++W+F +LS++ + + N 
Sbjct: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485

Query: 575 -NKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 633
              R G+ K+NI+F+E NY+T  ES +  +V LLSNLG Q+  W G SVL ++E  E++ 
Sbjct: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545

Query: 634 D---LLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGP 690
           D   + +I  + L +  R R       G     VA  + +     F P     S    GP
Sbjct: 546 DFVWITIIKLVALAKSLRQRRAQASYAG-PPPTVAELVEAHTNFGFQPDTAPRS-PNTGP 603

Query: 691 APS----PALTAPPPAYATLGPRP 710
            PS    P    PPP Y +L  +P
Sbjct: 604 YPSEQALPIPGTPPPNYDSLRLQP 627


>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
           1 [Homo sapiens]
          Length = 563

 Score =  149 bits (375), Expect = 1e-35
 Identities = 118/512 (23%), Positives = 220/512 (42%), Gaps = 88/512 (17%)

Query: 142 KTAFWAVLWLCTFGMMY-WQFGLLFGEYFSYPVSLNINLN-SDKLVFPAVTICTLNPYRY 199
           + A W + +  +FG++  W    L   + S+P    ++   S +L FPAVT+C  NP R+
Sbjct: 85  RRALWVLAFCTSFGLLLSWSSNRLL-YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143

Query: 200 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 259
           P + +              DLY    +  L+  +R+ R L                    
Sbjct: 144 PRLSKG-------------DLYYAGHWLGLLLPNRTARPL-------------------- 170

Query: 260 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 319
                V+  LR + P+  W      F+L    +                     H+  I 
Sbjct: 171 -----VSELLRGDEPRRQWFRKLADFRLFLPPR---------------------HFEGIS 204

Query: 320 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 379
           +   + L    ED L     +C++    C   N+S      YG CY FN   +    +++
Sbjct: 205 AAFMDRLGHQLEDML----LSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTT 259

Query: 380 MPG-INNGLSLMLRAEQNDFIPLLSTV------TGARVMVHGQDEPAFMDDGGFNLRPGV 432
           + G   NGL +ML  +Q++++P+           G +V +H Q EP F+ + GF + PG 
Sbjct: 260 VKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGF 319

Query: 433 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY 492
           +T ++ +++ L  L   +G+C  +   +   + +P  Y+   C   C    +++ C C  
Sbjct: 320 QTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-YSITACRIDCETRYIVENCNCRM 375

Query: 493 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRW 552
           +  P   +  +C   +H         L  +  S++  C   CR PC++T Y       + 
Sbjct: 376 VHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--CL--CRTPCNLTRYNKELSMVKI 429

Query: 553 PSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGS 612
           PS TS +++ +  ++   Y   N    +  ++IFF+ LNY+T  +  +  +  LL ++G 
Sbjct: 430 PSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485

Query: 613 QWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 644
           Q  L+ G+S+L+++E+ + +++L+    L LL
Sbjct: 486 QMGLFIGASILTILELFDYIYELIKEKLLDLL 517


>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
           [Homo sapiens]
          Length = 512

 Score =  148 bits (374), Expect = 2e-35
 Identities = 121/534 (22%), Positives = 228/534 (42%), Gaps = 93/534 (17%)

Query: 119 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN 178
           + F N +T+HG   +       ++   WAV ++ + G++  +       YFSY     ++
Sbjct: 18  QIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVD 77

Query: 179 -LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRR 237
            + +  LVFPAVT+C LN +             R +  T  DLY       L+       
Sbjct: 78  EVVAQSLVFPAVTLCNLNGF-------------RFSRLTTNDLYHAGELLALL------- 117

Query: 238 DLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 297
           D+   +P P   L  P          SV  +LR    + ++K +K               
Sbjct: 118 DVNLQIPDP--HLADP----------SVLEALRQ---KANFKHYKPK------------- 149

Query: 298 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFH 357
                         +F  +  L R+   L  +        +  C+F    C   +++   
Sbjct: 150 --------------QFSMLEFLHRVGHDLKDM--------MLYCKFKGQECGHQDFTTVF 187

Query: 358 HPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAEQNDFIPLLSTV------TGARV 410
              YG CY FN   +    ++++ G   NGL +ML  +Q++++P+           G +V
Sbjct: 188 -TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKV 246

Query: 411 MVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKY 470
            +H Q EP F+ + GF + PG +T ++ +++ L  L   +G+C  +   +   + +P  Y
Sbjct: 247 QIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-Y 302

Query: 471 TQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGC 530
           +   C   C    +++ C C  +  P   +  +C   +H         L  +  S++  C
Sbjct: 303 SITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--C 358

Query: 531 FTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL 590
              CR PC++T Y       + PS TS +++ +  ++   Y   N    +  ++IFF+ L
Sbjct: 359 L--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEAL 412

Query: 591 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 644
           NY+T  +  +  +  LL ++G Q  L+ G+S+L+++E+ + +++L+    L LL
Sbjct: 413 NYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 466


>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
           sapiens]
          Length = 549

 Score =  143 bits (361), Expect = 5e-34
 Identities = 114/419 (27%), Positives = 186/419 (44%), Gaps = 49/419 (11%)

Query: 333 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 391
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214

Query: 392 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 445
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274

Query: 446 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 493
           L   +GDC+            SD P+ +  PS    YT   C  +C    + ++CGC  +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333

Query: 494 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 553
           +   P +V  C  +++ +  +      +   S        C  PC+ T Y       R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385

Query: 554 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 613
           S  +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441

Query: 614 WSLWFGSSVLSVVEMAELVFDLLVIMFL-MLLRRFRSRYWSPGRGGRGAQEVASTLASSP 672
             L+ G+S+L+++E    + D L  +F   +L  F +R  S         +       + 
Sbjct: 442 MGLFIGASLLTILE----ILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQ 497

Query: 673 PSHFCPHPMSLSLSQ---PGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 728
             H    P +L  S+   P P PSP L+ PP A ATL     P        + C LG P
Sbjct: 498 VPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP--------AVCVLGAP 548



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 178
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78

Query: 179 LNSDKLVFPAVTICTLNPYR 198
             S +L+FPAVT+C +NP R
Sbjct: 79  RESHRLIFPAVTLCNINPLR 98


>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
           sapiens]
          Length = 543

 Score =  132 bits (332), Expect = 1e-30
 Identities = 106/397 (26%), Positives = 179/397 (45%), Gaps = 48/397 (12%)

Query: 333 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 391
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214

Query: 392 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 445
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274

Query: 446 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 493
           L   +GDC+            SD P+ +  PS    YT   C  +C    + ++CGC  +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333

Query: 494 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 553
           +   P +V  C  +++ +  +      +   S        C  PC+ T Y       R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385

Query: 554 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 613
           S  +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441

Query: 614 WSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPP 673
             L+ G+S+L+++E+ + + ++           FR +        + +Q  +ST  +S P
Sbjct: 442 MGLFIGASLLTILEILDYLCEV-----------FRDKVLGYFWNRQHSQRHSSTNLTSHP 490

Query: 674 SHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRP 710
           S  C H  SL L    P   P  TA      +  PRP
Sbjct: 491 S-LCRHQDSLRLP---PHLLPCHTALDLLSVSSEPRP 523



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 178
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78

Query: 179 LNSDKLVFPAVTICTLNPYR 198
             S +L+FPAVT+C +NP R
Sbjct: 79  RESHRLIFPAVTLCNINPLR 98


>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
           sapiens]
          Length = 531

 Score =  130 bits (327), Expect = 4e-30
 Identities = 99/380 (26%), Positives = 173/380 (45%), Gaps = 40/380 (10%)

Query: 333 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 391
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214

Query: 392 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 445
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274

Query: 446 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 493
           L   +GDC+            SD P+ +  PS    YT   C  +C    + ++CGC  +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333

Query: 494 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 553
           +   P +V  C  +++ +  +      +   S        C  PC+ T Y       R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385

Query: 554 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 613
           S  +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441

Query: 614 WSLWFGSSVLSVVEMAELVFDLL--VIMFLMLLRRFRSRYWS-----PGRGGRGAQEVAS 666
             L+ G+S+L+++E+ + + ++    ++     R+   R+ S      G G    Q    
Sbjct: 442 MGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHL 501

Query: 667 TLASSPPSHFCPHPMSLSLS 686
           +L   PP+  C    +LS S
Sbjct: 502 SLGPRPPTPPCAVTKTLSAS 521



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 178
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78

Query: 179 LNSDKLVFPAVTICTLNPYR 198
             S +L+FPAVT+C +NP R
Sbjct: 79  RESHRLIFPAVTLCNINPLR 98


>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
           b [Homo sapiens]
          Length = 528

 Score =  126 bits (317), Expect = 6e-29
 Identities = 76/308 (24%), Positives = 147/308 (47%), Gaps = 20/308 (6%)

Query: 336 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 394
           + + +C F    C+  ++       YG CYTFN   +    + +M G   NGL +ML  +
Sbjct: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225

Query: 395 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 448
           Q++++P+       S   G +V +H QDEP F+D  GF + PG +T ++ +++ L  L  
Sbjct: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285

Query: 449 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 508
            +G C     D  ++  +   Y+   C   C    +++ C C  +    P +  YC   +
Sbjct: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341

Query: 509 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 568
           +           +DF  +    +  C  PC++T Y       + PS  S +++ +  ++ 
Sbjct: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397

Query: 569 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEM 628
             Y   N    +  ++IFF+ LNY+T  +  +  +  LL ++G Q  L+ G+S+L+V+E+
Sbjct: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL 453

Query: 629 AELVFDLL 636
            +  ++++
Sbjct: 454 FDYAYEVI 461



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 179
           F +++T+HG   +   +   +K A WA+ +L +  ++          YF Y     ++ +
Sbjct: 21  FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80

Query: 180 NSDKLVFPAVTICTLNPYRYPEIKE 204
            + +L FPAVT+C LN +R+ ++ +
Sbjct: 81  AASQLTFPAVTLCNLNEFRFSQVSK 105


>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
           sapiens]
          Length = 666

 Score =  122 bits (307), Expect = 9e-28
 Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 30/314 (9%)

Query: 334 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 393
           L + + +C F+   C+ +N+S  +   YG CYTFN    S+L  S   G+ +GL +ML  
Sbjct: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357

Query: 394 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 447
           +Q +++P+       S   G RV +H Q+EP ++   GF + PG +T +S +++ L  L 
Sbjct: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417

Query: 448 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 507
             +G+C         E    S Y+   C   C +E++++ C C  +  P  + +  C   
Sbjct: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETI--CPPN 475

Query: 508 KHSSWGYCYYKLQVDFSSDHLG------CFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWV 561
                    Y    D + D LG      CF  C  PC++T Y       R P+  S  ++
Sbjct: 476 --------IYIECADHTLDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARYL 525

Query: 562 FQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 621
            +  +R   Y     R     +++FF+ L  +   +  +  +  LL +LG Q  L+ G+S
Sbjct: 526 ARKYNRNETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGAS 581

Query: 622 VLSVVEMAELVFDL 635
           +L+++E+ + ++++
Sbjct: 582 ILTLLEILDYIYEV 595



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/201 (24%), Positives = 80/201 (39%), Gaps = 18/201 (8%)

Query: 13  GVMGEGTQGPELSLDPDPCSPQSTPGLMK-GNKLEEQD--PRPLQPIPGLMEGNKLEEQD 69
           G  G G+  P          P   P L      LEEQ   P PL   PGL+       + 
Sbjct: 66  GAAGSGSDSPT-------SGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREA 118

Query: 70  SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEE----ALIEFHRSYRELFEFFCNNT 125
            + P S  G M      +     E A P++  A +E      +    + R+L  F  + +
Sbjct: 119 LASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATF-ASTS 176

Query: 126 TIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNINLNSDK 183
           T+HG  R      + ++   WA+  L +     +Q   L   Y + P  V+++    +  
Sbjct: 177 TLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPV 236

Query: 184 LVFPAVTICTLNPYRYPEIKE 204
             FPAVT+C +N +R+  + +
Sbjct: 237 AGFPAVTLCNINRFRHSALSD 257


>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
           sapiens]
          Length = 647

 Score =  117 bits (294), Expect = 3e-26
 Identities = 77/308 (25%), Positives = 142/308 (46%), Gaps = 37/308 (12%)

Query: 334 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 393
           L + + +C F+   C+ +N+S  +   YG CYTFN    S+L  S   G+ +GL +ML  
Sbjct: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357

Query: 394 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 447
           +Q +++P+       S   G RV +H Q+EP ++   GF + PG +T +S +++ L  L 
Sbjct: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417

Query: 448 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 507
             +G+C         E    S Y+   C   C +E++++ C C  +  P        D  
Sbjct: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--------DSL 469

Query: 508 KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR 567
                G C+                 C  PC++T Y       R P+  S  ++ +  +R
Sbjct: 470 GGGPEGPCF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNR 512

Query: 568 QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 627
              Y     R     +++FF+ L  +   +  +  +  LL +LG Q  L+ G+S+L+++E
Sbjct: 513 NETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568

Query: 628 MAELVFDL 635
           + + ++++
Sbjct: 569 ILDYIYEV 576



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/201 (24%), Positives = 80/201 (39%), Gaps = 18/201 (8%)

Query: 13  GVMGEGTQGPELSLDPDPCSPQSTPGLMK-GNKLEEQD--PRPLQPIPGLMEGNKLEEQD 69
           G  G G+  P          P   P L      LEEQ   P PL   PGL+       + 
Sbjct: 66  GAAGSGSDSPT-------SGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREA 118

Query: 70  SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEE----ALIEFHRSYRELFEFFCNNT 125
            + P S  G M      +     E A P++  A +E      +    + R+L  F  + +
Sbjct: 119 LASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATF-ASTS 176

Query: 126 TIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNINLNSDK 183
           T+HG  R      + ++   WA+  L +     +Q   L   Y + P  V+++    +  
Sbjct: 177 TLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPV 236

Query: 184 LVFPAVTICTLNPYRYPEIKE 204
             FPAVT+C +N +R+  + +
Sbjct: 237 AGFPAVTLCNINRFRHSALSD 257


>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
           a [Homo sapiens]
          Length = 574

 Score =  106 bits (265), Expect = 7e-23
 Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%)

Query: 336 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 394
           + + +C F    C+  ++       YG CYTFN   +    + +M G   NGL +ML  +
Sbjct: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225

Query: 395 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 448
           Q++++P+       S   G +V +H QDEP F+D  GF + PG +T ++ +++ L  L  
Sbjct: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285

Query: 449 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 508
            +G C     D  ++  +   Y+   C   C    +++ C C  +    P +  YC   +
Sbjct: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341

Query: 509 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 568
           +           +DF  +    +  C  PC++T Y       + PS  S +++ +  ++ 
Sbjct: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397

Query: 569 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNL 610
             Y   N    +  ++IFF+ LNY+T  +  +  +  LL  L
Sbjct: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 179
           F +++T+HG   +   +   +K A WA+ +L +  ++          YF Y     ++ +
Sbjct: 21  FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80

Query: 180 NSDKLVFPAVTICTLNPYRYPEIKE 204
            + +L FPAVT+C LN +R+ ++ +
Sbjct: 81  AASQLTFPAVTLCNLNEFRFSQVSK 105


>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
           sapiens]
          Length = 505

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 79/324 (24%), Positives = 145/324 (44%), Gaps = 28/324 (8%)

Query: 341 CRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINN-GLSLMLRAEQNDFI 399
           C F    C+  +++H     YGNC+TFN  +   L       ++  GLSL+    Q  F 
Sbjct: 185 CEFFGKPCSPKDFAHVFTE-YGNCFTFN--HGETLQAKRKVSVSGRGLSLLFNVNQEAFT 241

Query: 400 --PLLSTV-TGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKN 456
             P L  V  G   ++H   +    D  G     G+   +++R+         +G+C  N
Sbjct: 242 DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN 301

Query: 457 GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSW---- 512
              + ++N   S Y+   C+  C  + + K+CGC     P    +E CD +K+ S     
Sbjct: 302 ---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFLLPG-YGIE-CDLQKYFSCVSPV 354

Query: 513 -GYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNY 571
             +  +K      + +  C   C +      Y  +  YS +PS  + +++ + L++   Y
Sbjct: 355 LDHIEFKDLCTVGTHNSSCPVSCEE----IEYPATISYSSFPSQKALKYLSKKLNQSRKY 410

Query: 572 TVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 631
                R  + K+ I + +LNYK   +  +V++  LL++LG Q  L+ G+S+++++E+ E 
Sbjct: 411 I----RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466

Query: 632 VF-DLLVIMFLMLLRRFRSRYWSP 654
           +F +   I    LL+      W+P
Sbjct: 467 LFTNFYWICIFFLLKISEMTQWTP 490



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 2/79 (2%)

Query: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 180
           F  +T+ HG I  +    ++++   W V+ L +  ++ WQ  +    YF++P + +I + 
Sbjct: 41  FAISTSFHG-IHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99

Query: 181 -SDKLVFPAVTICTLNPYR 198
             +K+ FPAVT C LN ++
Sbjct: 100 YVEKMEFPAVTFCNLNRFQ 118


>gi|239755724 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 481

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 20/22 (90%), Positives = 21/22 (95%)

Query: 288 CNQNKSDCFYQTYSSGVDAVRE 309
           CNQNKSDCFYQTYSSGVDA R+
Sbjct: 215 CNQNKSDCFYQTYSSGVDAGRQ 236


>gi|148727370 immediate early response 5-like [Homo sapiens]
          Length = 404

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 31/81 (38%), Positives = 37/81 (45%), Gaps = 10/81 (12%)

Query: 657 GGRGAQEVASTLASSPPSHFCPHP-MSLSLSQPGPAPSPALTAPPPAYATLGPR------ 709
           GG GA       A+  P H  PH    L   QPGPAP P L  PPPA A L PR      
Sbjct: 148 GGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLP-LPLPPPAPAALCPRDPRAPA 206

Query: 710 --PSPGGSAGASSSTCPLGGP 728
              +P G+A  +++  P   P
Sbjct: 207 ACSAPPGAAPPAAAASPPASP 227


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/80 (35%), Positives = 38/80 (47%), Gaps = 13/80 (16%)

Query: 660 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSP------- 712
           GA    +  A SPP+   P P + + + P P P+PA  A PP +    P  +P       
Sbjct: 245 GAAAPPAPAAPSPPA--APAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAA 302

Query: 713 ---GGSAGASSSTCP-LGGP 728
              GGSAGA+ +  P  GGP
Sbjct: 303 AQNGGSAGAAPAPAPAAGGP 322



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 27/66 (40%), Positives = 33/66 (50%), Gaps = 4/66 (6%)

Query: 653 SPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSP 712
           SP R  + A   A TLA+S P+      M +  +  G  PSPA   PPPA  T  P   P
Sbjct: 346 SPKRVVQAAPPAAQTLAASGPASTAAS-MVIGPTMQGALPSPA-AVPPPAPGT--PTGLP 401

Query: 713 GGSAGA 718
            G+AGA
Sbjct: 402 KGAAGA 407



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 8/68 (11%)

Query: 665 ASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLG--------PRPSPGGSA 716
           A+  A+ PP    P  ++     P   P+ A   PPPA A  G        P P+ GG A
Sbjct: 264 AAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPA 323

Query: 717 GASSSTCP 724
           G S    P
Sbjct: 324 GVSGQPGP 331


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 17/111 (15%)

Query: 627 EMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTL---------ASSPPSHFC 677
           E  +L+ +L+V      L R R R  SPGRG  G       L          + PP+   
Sbjct: 401 EDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQR 460

Query: 678 PHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 728
           P P       P P P P    PP     L  RP P G    S    P G P
Sbjct: 461 PPPQG---GPPQPGPGPQRQGPP-----LQQRPPPQGQQHLSGLGPPAGSP 503



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 28/80 (35%), Positives = 31/80 (38%), Gaps = 1/80 (1%)

Query: 648 RSRYWSPGRGGRGAQEVASTLAS-SPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL 706
           + R   P  GG GA   A   AS SP     P   +   S  GPAP  A  APP      
Sbjct: 529 QGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQ 588

Query: 707 GPRPSPGGSAGASSSTCPLG 726
           GP   P G AG +      G
Sbjct: 589 GPPQKPPGPAGPTRQASQAG 608



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 25/69 (36%), Positives = 28/69 (40%), Gaps = 15/69 (21%)

Query: 654 PGRGG--RGAQEVASTLASSPPSHFCPHPMSLSLSQPGPA--PSPALT------APPPAY 703
           PG  G  R A +      + PP+   P P     S PGPA  P P L        PPPA 
Sbjct: 595 PGPAGPTRQASQAGPVPRTGPPTTQQPRP-----SGPGPAGRPKPQLAQKPSQDVPPPAT 649

Query: 704 ATLGPRPSP 712
           A  G  P P
Sbjct: 650 AAAGGPPHP 658


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 17/111 (15%)

Query: 627 EMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTL---------ASSPPSHFC 677
           E  +L+ +L+V      L R R R  SPGRG  G       L          + PP+   
Sbjct: 401 EDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQR 460

Query: 678 PHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 728
           P P       P P P P    PP     L  RP P G    S    P G P
Sbjct: 461 PPPQG---GPPQPGPGPQRQGPP-----LQQRPPPQGQQHLSGLGPPAGSP 503



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 28/80 (35%), Positives = 31/80 (38%), Gaps = 1/80 (1%)

Query: 648 RSRYWSPGRGGRGAQEVASTLAS-SPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL 706
           + R   P  GG GA   A   AS SP     P   +   S  GPAP  A  APP      
Sbjct: 529 QGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQ 588

Query: 707 GPRPSPGGSAGASSSTCPLG 726
           GP   P G AG +      G
Sbjct: 589 GPPQKPPGPAGPTRQASQAG 608



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 25/69 (36%), Positives = 28/69 (40%), Gaps = 15/69 (21%)

Query: 654 PGRGG--RGAQEVASTLASSPPSHFCPHPMSLSLSQPGPA--PSPALT------APPPAY 703
           PG  G  R A +      + PP+   P P     S PGPA  P P L        PPPA 
Sbjct: 595 PGPAGPTRQASQAGPVPRTGPPTTQQPRP-----SGPGPAGRPKPQLAQKPSQDVPPPAT 649

Query: 704 ATLGPRPSP 712
           A  G  P P
Sbjct: 650 AAAGGPPHP 658


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 21/50 (42%), Positives = 22/50 (44%)

Query: 672 PPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSS 721
           P   F P P   SL  P P PSP    PPP   T  P P   GS G  +S
Sbjct: 912 PSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTS 961


>gi|46409434 hypothetical protein LOC388759 [Homo sapiens]
          Length = 237

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 34/92 (36%), Positives = 44/92 (47%), Gaps = 16/92 (17%)

Query: 641 LMLLRRFRSRYWSPGRGGRG---AQEVASTLASSPPSHFCPHPMSLSLSQ-----PGPAP 692
           ++LL+   S  W+ GRG RG   +   A++ + S          SL   +     P P P
Sbjct: 76  VLLLQPEPSLTWAQGRGCRGHFRSLPAAASRSGSRTLRCASSDRSLREQKQRRAGPDPTP 135

Query: 693 SPALTAPPPAYATLGPRPSPGGSAGASSSTCP 724
           SPA   PPPA    GPRPSP GS G S+   P
Sbjct: 136 SPA---PPPA----GPRPSP-GSLGPSAPAAP 159


>gi|126116581 retina and anterior neural fold homeobox [Homo
           sapiens]
          Length = 346

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 27/73 (36%), Positives = 32/73 (43%), Gaps = 4/73 (5%)

Query: 656 RGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGP---RPSP 712
           RG RGA+E    L + P     P   S     P PAP+P   AP P Y    P   RPSP
Sbjct: 55  RGARGAKERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRP-YCPKEPGEARPSP 113

Query: 713 GGSAGASSSTCPL 725
           G   G ++    L
Sbjct: 114 GLPVGPATGEAKL 126


>gi|239754489 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 228

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)

Query: 644 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 697
           LRR R +    GRGGRGA               S P+H  P      L++P   PS A  
Sbjct: 124 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 178

Query: 698 APPPAYATLGPRPSPGGSAGASSS 721
           A   A A LG RP PGG AG   S
Sbjct: 179 AR--ASAGLGARPVPGGPAGPRES 200


>gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo
           sapiens]
          Length = 231

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)

Query: 644 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 697
           LRR R +    GRGGRGA               S P+H  P      L++P   PS A  
Sbjct: 127 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 181

Query: 698 APPPAYATLGPRPSPGGSAGASSS 721
           A   A A LG RP PGG AG   S
Sbjct: 182 AR--ASAGLGARPVPGGPAGPRES 203


>gi|239508715 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 231

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)

Query: 644 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 697
           LRR R +    GRGGRGA               S P+H  P      L++P   PS A  
Sbjct: 127 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 181

Query: 698 APPPAYATLGPRPSPGGSAGASSS 721
           A   A A LG RP PGG AG   S
Sbjct: 182 AR--ASAGLGARPVPGGPAGPRES 203


>gi|65288071 tensin 3 [Homo sapiens]
          Length = 1445

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 3/101 (2%)

Query: 10  RVPGVMGEGTQGPELSLDPDPCSP--QSTPGLMKGNKLEEQDPRPLQPIPGLMEGNKLEE 67
           R PG       GPELS  P P SP       + + N+L  +     +PIP  M     + 
Sbjct: 668 RFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQA 727

Query: 68  QDSSPPQSTPGLMKGNKR-EEQGLGPEPAAPQQPTAEEEAL 107
             S  P S  G ++ + R  + G GP  A  +Q ++ E+ L
Sbjct: 728 NGSVSPDSVGGGLRASSRLPDTGEGPSRATGRQGSSAEQPL 768


>gi|206597556 kelch domain containing 7B [Homo sapiens]
          Length = 594

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 29/99 (29%), Positives = 40/99 (40%), Gaps = 7/99 (7%)

Query: 12  PGVMGEGTQGPELSLDPDPCS-----PQSTPGLMKGNKLEEQDPRPLQPIPGLMEGNKLE 66
           PG+ GEGT+  E SLDP P +     P   P             R  QP+P L + ++ E
Sbjct: 80  PGLRGEGTR--EKSLDPLPQAAMPRGPAQPPAQRPPGPAASSSARRSQPVPQLRKRSRCE 137

Query: 67  EQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEE 105
              SS  +  P      + E  G G  PA       E++
Sbjct: 138 IAPSSEQEVRPAASGDPQGEAPGEGGSPAGRSGALTEKQ 176


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,544,269
Number of Sequences: 37866
Number of extensions: 1893429
Number of successful extensions: 14666
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 109
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 12322
Number of HSP's gapped (non-prelim): 2319
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.