Search of human proteins with 226437581

Search of human proteins with 226437581

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
sapiens]
         (623 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...  1260   0.0  
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...  1260   0.0  
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         877   0.0  
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   466   e-131
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         441   e-123
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        440   e-123
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   407   e-113
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         399   e-111
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   310   2e-84
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         295   6e-80
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            288   1e-77
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            272   6e-73
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   260   3e-69
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   222   7e-58
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   210   4e-54
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   210   4e-54
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   210   4e-54
gi|171184408 solute carrier family 6 (neurotransmitter transport...   209   6e-54
gi|171184406 solute carrier family 6 (neurotransmitter transport...   209   6e-54
gi|171184404 solute carrier family 6 (neurotransmitter transport...   209   6e-54
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   205   9e-53
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   205   1e-52
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   201   2e-51
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   200   3e-51
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   198   1e-50
gi|188528618 solute carrier family 6 (neurotransmitter transport...   198   1e-50
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   190   3e-48
gi|197276623 solute carrier family 6 (neurotransmitter transport...   188   1e-47
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   188   1e-47
gi|197276625 solute carrier family 6 (neurotransmitter transport...    80   4e-15

>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score = 1260 bits (3261), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF
Sbjct: 108 MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 167

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK
Sbjct: 168 YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 227

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
           MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT
Sbjct: 228 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 287

Query: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
           PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL
Sbjct: 288 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 347

Query: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300
           ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY
Sbjct: 348 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 407

Query: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360
           DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML
Sbjct: 408 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 467

Query: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420
           VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY
Sbjct: 468 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 527

Query: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480
           SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA
Sbjct: 528 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 587

Query: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540
           SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD
Sbjct: 588 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 647

Query: 541 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 600
           SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA
Sbjct: 648 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 707

Query: 601 PNGRYGIGYLMADIMPDMPESDL 623
           PNGRYGIGYLMADIMPDMPESDL
Sbjct: 708 PNGRYGIGYLMADIMPDMPESDL 730


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score = 1260 bits (3261), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
           MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT
Sbjct: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180

Query: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
           PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL
Sbjct: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240

Query: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300
           ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY
Sbjct: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300

Query: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360
           DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML
Sbjct: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360

Query: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420
           VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY
Sbjct: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420

Query: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480
           SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA
Sbjct: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480

Query: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540
           SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD
Sbjct: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540

Query: 541 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 600
           SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA
Sbjct: 541 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 600

Query: 601 PNGRYGIGYLMADIMPDMPESDL 623
           PNGRYGIGYLMADIMPDMPESDL
Sbjct: 601 PNGRYGIGYLMADIMPDMPESDL 623


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  877 bits (2265), Expect = 0.0
 Identities = 414/626 (66%), Positives = 519/626 (82%), Gaps = 8/626 (1%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           ++IGIPLFFLEL+VGQRIRRGSIGVW+YI P+LGGIGF+SC+VC FV LYYNVIIGWS+F
Sbjct: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           YF +SFQ PLPW +CP+V+N S   VE ECE+SSATTY+WYREAL+IS SISESGGLNWK
Sbjct: 167 YFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWK 226

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
           MT+CLL AW +V +A++KGIQSSGK++YFSSLFPYVVL CFL+R  LL G++DGI HMFT
Sbjct: 227 MTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFT 286

Query: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
           PKL+ ML+P+VWREAATQVFFALGLGFGGVIAFSSYNK+DNNCHFDA LVSFINFFTSVL
Sbjct: 287 PKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346

Query: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300
           ATLVVFAVLGFKAN++NEKC+ +N+E I+ +L    +S+D+IP H+N S +T +DY  +Y
Sbjct: 347 ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMY 406

Query: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360
           ++I  VKE++F AL L+ C +E+EL+K+VQGTGLAFIAFTEAMTHFPASPFWSVMFFLML
Sbjct: 407 NVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 466

Query: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420
           +NLGLGSM GT+ GI TPI+DTFKV KE+ TV CC+ AF +GL+FVQRSGNYFVTMFDDY
Sbjct: 467 INLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDY 526

Query: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480
           SATLPL ++VILENIAV ++YG  KFM++L +MLGF P R+Y+YMWK++SPL +  L  A
Sbjct: 527 SATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTA 586

Query: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540
           S++ +G++PPGY+AWI+++A+E +L +P W + + ++L+V A LP+PVVF++R F+L+ D
Sbjct: 587 SIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSD 646

Query: 541 SSGNLASVTYKRGRVLKEPVNL-EGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDT 599
            S N  SV+YK+GR++K+  NL E D+T  I  K+PSE PSP      Y     +  L+T
Sbjct: 647 GS-NTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLET 705

Query: 600 A--PNGRYGIGYLMADIMPDMPESDL 623
           +  PNGRYG GYL+A      PES+L
Sbjct: 706 SGNPNGRYGSGYLLA----STPESEL 727


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  466 bits (1198), Expect = e-131
 Identities = 239/550 (43%), Positives = 349/550 (63%), Gaps = 35/550 (6%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           +V G+PL +LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +
Sbjct: 52  IVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFW 111

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           Y   SFQ PLPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+
Sbjct: 112 YLFHSFQDPLPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWE 169

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
             +CLL AW++V L +++G +S+GK++YF++  PY VLI +LIR   L+G+ +G+ +MFT
Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFT 229

Query: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
           PK+E +  PK W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ 
Sbjct: 230 PKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 289

Query: 241 ATLVVFAVLGFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTA 293
           A++V F++ GFKA    E C+ + S  +         FL   N+ Q        +    A
Sbjct: 290 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLA 341

Query: 294 EDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 353
             Y   Y        E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WS
Sbjct: 342 SAYPSKY-------SEMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWS 392

Query: 354 VMFFLMLVNLGLGSMFGTIEGIVTPIVD----TFKVRKEILTVICCLLAFCIGLIFVQRS 409
           V++F ML+ LG+GSM G    I+TP+ D    +  + KE ++ + CL+   IG++F   +
Sbjct: 393 VLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEA 452

Query: 410 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 469
           GNY+  +F+DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +
Sbjct: 453 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGV 512

Query: 470 SPLMLLSLLIASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 528
           SPL+++SL +  + +  L+    Y AW   +       YP + L V   LV  + + +P+
Sbjct: 513 SPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572

Query: 529 ----VFIVRR 534
                F+ RR
Sbjct: 573 AALGTFVQRR 582


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  441 bits (1134), Expect = e-123
 Identities = 229/538 (42%), Positives = 326/538 (60%), Gaps = 35/538 (6%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIPL +LE ++GQR+RRGS+GVW+ I P L G+G AS +  + V LYYN II W ++Y  
Sbjct: 82  GIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLF 141

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTI 123
            SFQ+PLPW  CPL  N + T    EC +SS   Y+WYRE LNIS+SIS+SG + W M +
Sbjct: 142 NSFQEPLPWSDCPL--NENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLL 199

Query: 124 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 183
           CL  AW ++ +  I+GI+++GK +Y +S  PYVVL  FLIR   L G+ +GI  +FTP +
Sbjct: 200 CLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNV 259

Query: 184 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 243
             + +P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+V+VS IN FTSV   +
Sbjct: 260 TELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAI 319

Query: 244 VVFAVLGFKANVINEKCITQNSETIMK--FLKMGNISQDIIPHHINLSTVTAEDYHLVYD 301
           VV++V+GF+A    + C + N  T++    L  GN++Q+                    D
Sbjct: 320 VVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF-----------------VD 362

Query: 302 IIQKVKEEE---FPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFL 358
           + Q+    +   +  L   +C I   L++AV+GTGLAFI FTEA+T  P SP WSV+FF+
Sbjct: 363 MQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFI 422

Query: 359 MLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFV 414
           ML  LGL SMFG +EG+V P+ D      K  KE+LT + CL  F IG IF   SG Y++
Sbjct: 423 MLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWL 482

Query: 415 TMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLML 474
           ++ D Y+ ++PLLI+   E  +V +VYG+D+F +D++ M+G  P+ ++   W+ +SPL++
Sbjct: 483 SLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLM 542

Query: 475 LSLLIASVVNMGLSPPGYNAWIEDKASEEF-----LSYPTWGLVVCVSLVVFAILPVP 527
           L + +   V        Y+ W  D   EEF     +SYP W  VV V +     L +P
Sbjct: 543 LIIFLFFFVVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIP 598


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  440 bits (1131), Expect = e-123
 Identities = 219/537 (40%), Positives = 335/537 (62%), Gaps = 22/537 (4%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIP+F +EL++GQR+R+GS+GVW  ISP L G+G     + + ++LYYN I+ W L+Y  
Sbjct: 68  GIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLL 127

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTI 123
            SFQ PLPW  CP   N +  FVE EC+ SSA +Y+WYR+ LNI++ I++SG + W + I
Sbjct: 128 NSFQHPLPWSSCPPDLNRTG-FVE-ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLI 185

Query: 124 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 183
           CL A+W +V + +I+GI+++GK+IYF++LFPY+VL  FLIR   L G+  G+ ++FTP +
Sbjct: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245

Query: 184 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 243
            I+  P+VW +AATQ+FF+L L FGG IAF+SYN   N+C  DAV+++ +N  TS+ A++
Sbjct: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305

Query: 244 VVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDII 303
            VF+VLGFKA    E C+ +N  +++                    +++ +DY  V   +
Sbjct: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPE------------QSISRDDYPAVLMHL 353

Query: 304 QKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNL 363
                +    L L +C +E+ L+K+  G GLAF+ FTE   H P +P W+++FF ML  L
Sbjct: 354 NATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTL 413

Query: 364 GLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDD 419
           GL +MFGT+E ++TP++D       V KE LT + CL+ F     F  +SGNY++ +FD+
Sbjct: 414 GLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDN 473

Query: 420 YSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLI 479
           ++A+  LL++  LE + V +VYG+ +F +D+  M G  PS Y+   W+ +SPL LL++ +
Sbjct: 474 FAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPL-LLTIFV 532

Query: 480 ASVVNMGLSPPGYNAW---IEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
           A ++ +   P  Y AW    E   S +   YP W    CV L +  +L VPV  + +
Sbjct: 533 AYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  407 bits (1045), Expect = e-113
 Identities = 222/550 (40%), Positives = 321/550 (58%), Gaps = 72/550 (13%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           +V G+PL +LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +
Sbjct: 52  IVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFW 111

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           Y   SFQ PLPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+
Sbjct: 112 YLFHSFQDPLPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWE 169

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
             +CLL AW++V L +++G +S+GKI                                  
Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKI---------------------------------- 195

Query: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
              E +  PK W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ 
Sbjct: 196 ---EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 252

Query: 241 ATLVVFAVLGFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTA 293
           A++V F++ GFKA    E C+ + S  +         FL   N+ Q        +    A
Sbjct: 253 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLA 304

Query: 294 EDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 353
             Y   Y        E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WS
Sbjct: 305 SAYPSKYS-------EMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWS 355

Query: 354 VMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVR----KEILTVICCLLAFCIGLIFVQRS 409
           V++F ML+ LG+GSM G    I+TP+ D+  +     KE ++ + CL+   IG++F   +
Sbjct: 356 VLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEA 415

Query: 410 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 469
           GNY+  +F+DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +
Sbjct: 416 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGV 475

Query: 470 SPLMLLSLLIASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 528
           SPL+++SL +  + +  L+    Y AW   +       YP + L V   LV  + + +P+
Sbjct: 476 SPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535

Query: 529 ----VFIVRR 534
                F+ RR
Sbjct: 536 AALGTFVQRR 545


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  399 bits (1026), Expect = e-111
 Identities = 197/540 (36%), Positives = 315/540 (58%), Gaps = 7/540 (1%)

Query: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
           ++G+PL FLE++ GQ +R+G +GVW  I+P +GG+G++S +VC+ + LY+NV+  W +FY
Sbjct: 151 LVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFY 210

Query: 62  FSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKM 121
            SQSFQ P+PW++CPL  N+S    +PECE+++ + Y+WY++AL  S  I + G   + +
Sbjct: 211 MSQSFQFPVPWEKCPLTMNSSG--FDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSL 268

Query: 122 TICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTP 181
            +     W +V   MI G++S+GK+IY   L P  +++ F IR  LL G+  G++ +   
Sbjct: 269 VLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVA 328

Query: 182 KLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLA 241
           K+  +    VW  A  QV    G+G G V + +SY  + NNC  DA LVS IN  T ++ 
Sbjct: 329 KISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVF 388

Query: 242 TLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYD 301
           T   F VLGF A VI  +C  +N+E ++K + +G +  D  P    L   T+     +  
Sbjct: 389 TSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSG 448

Query: 302 IIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLV 361
           + Q +K        +  C IE +  KA +G   AF++F EAM+  P S FWS +FFLML+
Sbjct: 449 LPQHIK--SMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLL 506

Query: 362 NLGLGSMFGTIEGIVTPIVDT---FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 418
            +GL S  G ++GI+TP+ DT   F+   ++L V   LL F  GL F + SG+YF+ +  
Sbjct: 507 AMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLS 566

Query: 419 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 478
           DY    P+++VV+ E +AV + YG  +F+ DL  +LG   S  + ++W ++ P++LL + 
Sbjct: 567 DYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIF 626

Query: 479 IASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLI 538
           +  +V++ + P  Y +W    + E    YP W L++ ++L    ILP+P  F+  R + I
Sbjct: 627 VTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRI 686


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  310 bits (795), Expect = 2e-84
 Identities = 151/172 (87%), Positives = 159/172 (92%), Gaps = 3/172 (1%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF
Sbjct: 108 MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 167

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
           YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK
Sbjct: 168 YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 227

Query: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSI 172
           MTICLLAAWVMVCLAMIKGIQSSGK+   S L P+++L+  +     L+ S+
Sbjct: 228 MTICLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLITISGFIPLSNSV 276


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  295 bits (756), Expect = 6e-80
 Identities = 181/550 (32%), Positives = 273/550 (49%), Gaps = 97/550 (17%)

Query: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
           + GIPLFFLELS+GQ    G + VW  ISP   G G A  ++   VA+YYN+II + LFY
Sbjct: 85  ICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFY 143

Query: 62  FSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTYYWYREALNISS 109
              S    LPW+ C    N          +              S +  YW R  L+I  
Sbjct: 144 LFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQG 203

Query: 110 S--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 167
           S  I   G + W + +CLL AWV+V L ++KG++SSGK++YF++ FPY++L+  L+R   
Sbjct: 204 SQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVT 263

Query: 168 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 227
           L G+  GI+   TP+   +L  KVW EAA Q+F++LG+GFGG++ F+SYN    N + D 
Sbjct: 264 LPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDT 323

Query: 228 VLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDI-IPHHI 286
                   F   L   +   + GF                   F  +G +SQ++ +P   
Sbjct: 324 --------FIVTLGNAITSILAGFAI-----------------FSVLGYMSQELGVP--- 355

Query: 287 NLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHF 346
                                               +++ KA  G GLAF+ + +AMT  
Sbjct: 356 -----------------------------------VDQVAKA--GPGLAFVVYPQAMTML 378

Query: 347 PASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIG 402
           P SPFWS +FF ML+ LGL S F  +E IVT + D F    + +K + + + C+  + +G
Sbjct: 379 PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMG 438

Query: 403 LIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYY 462
           LI     G Y++ + DDYSA+  L++VVI   +AV  VYGI +F  D+  MLGF P  Y+
Sbjct: 439 LILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYF 498

Query: 463 YYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFA 522
              W ++SP  LL+L++ S+V     P  Y ++           +P W  ++ + + + +
Sbjct: 499 RACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPPWAELLGILMGLLS 546

Query: 523 ILPVPVVFIV 532
            L +P   +V
Sbjct: 547 CLMIPAGMLV 556


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  288 bits (736), Expect = 1e-77
 Identities = 170/557 (30%), Positives = 274/557 (49%), Gaps = 107/557 (19%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           ++ G+PLF++EL++GQ  R G+  VW  I P   G+G+A  ++  +V  YYNVII WSL+
Sbjct: 103 IIAGMPLFYMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLY 161

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQ---------SSATTYYWYREA------- 104
           Y   SF   LPW  C       HT+  P C            + T Y  Y+         
Sbjct: 162 YLFSSFTLNLPWTDC------GHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYE 215

Query: 105 -----LNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLI 159
                L+ SS I + G   W++ +CL+   +++  ++ KG+++SGK+++ ++  PY VL 
Sbjct: 216 RGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLF 275

Query: 160 CFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKR 219
             L+    L G+ +GI          + E  VW +AATQ+FF+LG GFG +IAF+SYNK 
Sbjct: 276 VLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKF 335

Query: 220 DNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQ 279
           DNNC+ DA+L S IN  TS ++   +F++LG+ A+                         
Sbjct: 336 DNNCYRDALLTSSINCITSFVSGFAIFSILGYMAH------------------------- 370

Query: 280 DIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAF 339
               H +N+  V  E                                    G GL FI +
Sbjct: 371 ---EHKVNIEDVATE------------------------------------GAGLVFILY 391

Query: 340 TEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRK---EILTVICCL 396
            EA++    S FW+V+FF+ML+ LGL S  G +E ++T + D F+V K   ++ T     
Sbjct: 392 PEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTF 451

Query: 397 LAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGF 456
             F + L  + + G Y +T+ D ++A   +L  V++E I V + YG+D+F  D++ M+GF
Sbjct: 452 STFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGF 511

Query: 457 APSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCV 516
            P  Y+   WK++SP  LL +++ S++N    P  Y+ +I          +P W   V  
Sbjct: 512 RPGLYWRLCWKFVSPAFLLFVVVVSIIN--FKPLTYDDYI----------FPPWANWVGW 559

Query: 517 SLVVFAILPVPVVFIVR 533
            + + +++ VP+  I +
Sbjct: 560 GIALSSMVLVPIYVIYK 576


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  272 bits (696), Expect = 6e-73
 Identities = 160/542 (29%), Positives = 273/542 (50%), Gaps = 90/542 (16%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIPLF++EL++GQ  R G I +W  I P   GIG+A C++ +++A YYN I+ W+L+Y  
Sbjct: 129 GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLI 188

Query: 64  QSFQQPLPWDQCPL---VKNASHTFVEPEC----EQSSATTYYWYREALNI--SSSISES 114
            SF   LPW  C       N ++ F E         +S    ++ R  L I  S  + + 
Sbjct: 189 SSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDL 248

Query: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174
           GG++W++ +C++  + ++  ++ KG+++SGK+++ ++ FPY++L   L+R   L G+  G
Sbjct: 249 GGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRG 308

Query: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234
           +     P  + +LE  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC           
Sbjct: 309 VLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNC----------- 357

Query: 235 FFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAE 294
            +   L T VV              C+T      + F  +G +++               
Sbjct: 358 -YQDALVTSVV-------------NCMTSFVSGFVIFTVLGYMAE--------------- 388

Query: 295 DYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSV 354
                      ++ E+          + E    A  G  L FI + EA+ + PAS F+++
Sbjct: 389 -----------MRNED----------VSEVAKDA--GPSLLFITYAEAIANMPASTFFAI 425

Query: 355 MFFLMLVNLGLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSG 410
           +FFLML+ LGL S F  +EG++T ++D F      R+E   +   +  F   L+ +   G
Sbjct: 426 IFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGG 485

Query: 411 NYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYIS 470
            Y V + ++Y+    +L V ++E +AV + YGI +F  D+K+MLGF+P  ++   W  IS
Sbjct: 486 AYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAIS 545

Query: 471 PLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVV--CVSLVVFAILPVPV 528
           PL LL ++ + +    +SPP    +          +YP W +++  C+    F  +P  +
Sbjct: 546 PLFLLFIICSFL----MSPPQLRLF--------QYNYPYWSIILGYCIGTSSFICIPTYI 593

Query: 529 VF 530
            +
Sbjct: 594 AY 595


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  260 bits (664), Expect = 3e-69
 Identities = 164/551 (29%), Positives = 266/551 (48%), Gaps = 106/551 (19%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           ++ G+PLF++EL++GQ  R G+ GVW  I P L G+GF   ++  +V  +YNVII W+L 
Sbjct: 107 VIAGMPLFYMELALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALH 165

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------------SATTYYWYR 102
           Y   SF   LPW  C      ++++  P C  +                  +    Y+ R
Sbjct: 166 YLFSSFTTELPWIHC------NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFER 219

Query: 103 EALNISSS--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLIC 160
             L++  S  I + G   W++T CL+   V++  ++ KG+++SGK+++ ++  PYVVL  
Sbjct: 220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTA 279

Query: 161 FLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRD 220
            L+R   L G+IDGIR   +     + E  VW +AATQV F+LG+GFG +IAFSSYNK  
Sbjct: 280 LLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFT 339

Query: 221 NNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQD 280
           N            N +   + T  + ++  F +  +           +  FL  G ++Q 
Sbjct: 340 N------------NCYRDAIVTTSINSLTSFSSGFV-----------VFSFL--GYMAQK 374

Query: 281 IIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFT 340
              H + +  V                                    A  G GL FI + 
Sbjct: 375 ---HSVPIGDV------------------------------------AKDGPGLIFIIYP 395

Query: 341 EAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKV---RKEILTVICCLL 397
           EA+   P S  W+V+FF+ML+ LG+ S  G +E ++T ++D F++    +E+ T+   L 
Sbjct: 396 EAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLA 455

Query: 398 AFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFA 457
            F + L  V   G Y  T+ D ++A   +L  V++E I V + YG+ +F +D++ M G  
Sbjct: 456 TFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQR 515

Query: 458 PSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVS 517
           PS Y+   WK +SP  LL +++ S+V     PP Y A+I          +P W   +   
Sbjct: 516 PSLYWRLCWKLVSPCFLLFVVVVSIVT--FRPPHYGAYI----------FPDWANALGWV 563

Query: 518 LVVFAILPVPV 528
           +   ++  VP+
Sbjct: 564 IATSSMAMVPI 574


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  222 bits (566), Expect = 7e-58
 Identities = 108/276 (39%), Positives = 164/276 (59%), Gaps = 30/276 (10%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           +V GIP+FFLE+S+GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +
Sbjct: 99  LVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFY 157

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPEC-----------------------EQSSATT 97
           Y  +SF   LPW  C       HT+  P+C                       ++ S   
Sbjct: 158 YLVKSFTTTLPWATC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVI 211

Query: 98  YYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVV 157
            +W  + L +S  +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVV
Sbjct: 212 EFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVV 271

Query: 158 LICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYN 217
           L+  L+R  LL G++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN
Sbjct: 272 LVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYN 331

Query: 218 KRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 253
           + +NNC+ DA++++ IN  TS  A  VVF++LGF A
Sbjct: 332 RFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMA 367



 Score =  125 bits (315), Expect = 9e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 378 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 437

Query: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 438 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 497

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 498 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 546

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528
                 YP WG  +  +  + ++L VP+
Sbjct: 547 YNNTYVYPWWGEAMGWAFALSSMLCVPL 574


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  210 bits (534), Expect = 4e-54
 Identities = 108/276 (39%), Positives = 159/276 (57%), Gaps = 27/276 (9%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIPLFF+ELS GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF 
Sbjct: 77  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 135

Query: 64  QSFQQPLPWDQC-------------------------PLVKNASHTFVEPECEQSSATTY 98
            S    LPW  C                          L  N SH  +    +++S +  
Sbjct: 136 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEE 194

Query: 99  YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVL 158
           YW    L +S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL
Sbjct: 195 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 254

Query: 159 ICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNK 218
               +R   L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK
Sbjct: 255 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNK 314

Query: 219 RDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254
             NNC+ D+V++S  N  TSV A  V+F++LGF AN
Sbjct: 315 FHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 350



 Score =  127 bits (319), Expect = 3e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 360 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 419

Query: 383 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 442
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 420 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 479

Query: 443 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 502
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 480 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 530

Query: 503 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
               YP W + +   + + ++L +P+  + R
Sbjct: 531 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 558


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  210 bits (534), Expect = 4e-54
 Identities = 108/276 (39%), Positives = 159/276 (57%), Gaps = 27/276 (9%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIPLFF+ELS GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF 
Sbjct: 150 GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 208

Query: 64  QSFQQPLPWDQC-------------------------PLVKNASHTFVEPECEQSSATTY 98
            S    LPW  C                          L  N SH  +    +++S +  
Sbjct: 209 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEE 267

Query: 99  YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVL 158
           YW    L +S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL
Sbjct: 268 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 327

Query: 159 ICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNK 218
               +R   L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK
Sbjct: 328 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNK 387

Query: 219 RDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254
             NNC+ D+V++S  N  TSV A  V+F++LGF AN
Sbjct: 388 FHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 423



 Score =  127 bits (319), Expect = 3e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 433 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 492

Query: 383 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 442
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 493 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 552

Query: 443 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 502
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 553 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 603

Query: 503 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
               YP W + +   + + ++L +P+  + R
Sbjct: 604 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 631


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  210 bits (534), Expect = 4e-54
 Identities = 108/276 (39%), Positives = 159/276 (57%), Gaps = 27/276 (9%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIPLFF+ELS GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF 
Sbjct: 96  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 154

Query: 64  QSFQQPLPWDQC-------------------------PLVKNASHTFVEPECEQSSATTY 98
            S    LPW  C                          L  N SH  +    +++S +  
Sbjct: 155 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEE 213

Query: 99  YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVL 158
           YW    L +S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL
Sbjct: 214 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 273

Query: 159 ICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNK 218
               +R   L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK
Sbjct: 274 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNK 333

Query: 219 RDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254
             NNC+ D+V++S  N  TSV A  V+F++LGF AN
Sbjct: 334 FHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 369



 Score =  127 bits (319), Expect = 3e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 379 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 438

Query: 383 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 442
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 439 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 498

Query: 443 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 502
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 499 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 549

Query: 503 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
               YP W + +   + + ++L +P+  + R
Sbjct: 550 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 577


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  209 bits (532), Expect = 6e-54
 Identities = 103/260 (39%), Positives = 152/260 (58%), Gaps = 10/260 (3%)

Query: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
           V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ W+LFY
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 62  FSQSFQQPLPWDQCPLVKNASHTF----------VEPECEQSSATTYYWYREALNISSSI 111
              SF   LPW  C    N  H            V P    +S    +W R  L I+S I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 112 SESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGS 171
            + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 172 IDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVS 231
             GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 232 FINFFTSVLATLVVFAVLGF 251
           F+N  TS +A  VVF++LGF
Sbjct: 324 FLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 4e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 384 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 440
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 532
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  209 bits (532), Expect = 6e-54
 Identities = 103/260 (39%), Positives = 152/260 (58%), Gaps = 10/260 (3%)

Query: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
           V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ W+LFY
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 62  FSQSFQQPLPWDQCPLVKNASHTF----------VEPECEQSSATTYYWYREALNISSSI 111
              SF   LPW  C    N  H            V P    +S    +W R  L I+S I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 112 SESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGS 171
            + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 172 IDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVS 231
             GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 232 FINFFTSVLATLVVFAVLGF 251
           F+N  TS +A  VVF++LGF
Sbjct: 324 FLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 4e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 384 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 440
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 532
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  209 bits (532), Expect = 6e-54
 Identities = 103/260 (39%), Positives = 152/260 (58%), Gaps = 10/260 (3%)

Query: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
           V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ W+LFY
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 62  FSQSFQQPLPWDQCPLVKNASHTF----------VEPECEQSSATTYYWYREALNISSSI 111
              SF   LPW  C    N  H            V P    +S    +W R  L I+S I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 112 SESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGS 171
            + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 172 IDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVS 231
             GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 232 FINFFTSVLATLVVFAVLGF 251
           F+N  TS +A  VVF++LGF
Sbjct: 324 FLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 4e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 384 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 440
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 532
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  205 bits (522), Expect = 9e-53
 Identities = 104/276 (37%), Positives = 156/276 (56%), Gaps = 40/276 (14%)

Query: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
           +V GIP+FFLE+S+GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +
Sbjct: 99  LVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFY 157

Query: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPEC-----------------------EQSSATT 97
           Y  +SF   LPW  C       HT+  P+C                       ++ S   
Sbjct: 158 YLVKSFTTTLPWATC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVI 211

Query: 98  YYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVV 157
            +W  + L +S  +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVV
Sbjct: 212 EFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVV 271

Query: 158 LICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYN 217
           L+  L+R  LL G++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN
Sbjct: 272 LVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYN 331

Query: 218 KRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 253
           + +NNC+            TS  A  VVF++LGF A
Sbjct: 332 RFNNNCYNG----------TSFFAGFVVFSILGFMA 357



 Score =  125 bits (315), Expect = 9e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427

Query: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 536

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528
                 YP WG  +  +  + ++L VP+
Sbjct: 537 YNNTYVYPWWGEAMGWAFALSSMLCVPL 564


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  205 bits (521), Expect = 1e-52
 Identities = 110/291 (37%), Positives = 161/291 (55%), Gaps = 40/291 (13%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+PLFFLE S+GQ    G + VW  I P   G+G    ++  FV +YYNVII +SL+Y  
Sbjct: 86  GLPLFFLECSLGQFASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMF 144

Query: 64  QSFQQPLPWDQCPLV--KNASHTFVEPECEQSSA-------------------------- 95
            SFQ  LPW  C     KN S + +   C  S+                           
Sbjct: 145 ASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGS 204

Query: 96  ---------TTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKI 146
                    +  YW + AL  SS ++E+G + W + +CLL AW++V  A+ KGI+SSGK+
Sbjct: 205 EIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKV 264

Query: 147 IYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEI--MLEPKVWREAATQVFFALG 204
           +YF++LFPYVVL+  L+R   L G+  GI +    +     + E +VW++AATQ+F++L 
Sbjct: 265 VYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLS 324

Query: 205 LGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANV 255
           + +GG++A SSYNK  NNC  DA++V   N  TSV A   +F++LG  A++
Sbjct: 325 VAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHI 375


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  201 bits (510), Expect = 2e-51
 Identities = 109/296 (36%), Positives = 159/296 (53%), Gaps = 52/296 (17%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+P+FFLE+S+GQ   +G + VW  I P L G G A  ++   +A+YYNVII ++LFY  
Sbjct: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQS------------------------------ 93
            SF   LPW  C      ++ +  PEC+                                
Sbjct: 300 ASFVSVLPWGSC------NNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPN 353

Query: 94  ---------------SATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIK 138
                          S +  Y+    L IS+ I   G + W + +CL  AWV+V  ++ K
Sbjct: 354 VTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAK 413

Query: 139 GIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQ 198
           GI++SGK++YF++ FPYVVL+  LIR   L G+  GI +  TPK E + +  VW++AATQ
Sbjct: 414 GIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQ 473

Query: 199 VFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254
           +FF+L   +GG+I  SSYNK  NNC+ D ++V+  N  TS+ A  V+F+V+GF AN
Sbjct: 474 IFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529



 Score =  151 bits (381), Expect = 2e-36
 Identities = 75/221 (33%), Positives = 128/221 (57%), Gaps = 17/221 (7%)

Query: 317 NSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIV 376
           N  K+  E N A QG G+AF+ + EA+T  P SPFW+++FFLML+ LGL +MF TIE IV
Sbjct: 529 NERKVNIE-NVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIV 587

Query: 377 TPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVIL 432
           T I D F    +  K + T+ CC+  F +G   + + G Y   + D Y+A+  L+I+ I 
Sbjct: 588 TSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIF 647

Query: 433 ENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGY 492
           E + + +VYG+ +F ED++ M+GF P+ ++   W +++P +L  +L  S       P  Y
Sbjct: 648 ELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTY 705

Query: 493 NAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
            ++           YP W +V+   ++  +++ +P++F+++
Sbjct: 706 GSY----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  200 bits (509), Expect = 3e-51
 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%)

Query: 18  IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 77
           ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW  C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57

Query: 78  VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 114
                HT+  P+C                       ++ S    +W  + L +S  +   
Sbjct: 58  ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113

Query: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174
           G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G++DG
Sbjct: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173

Query: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234
           I +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA++++ IN
Sbjct: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233

Query: 235 FFTSVLATLVVFAVLGFKA 253
             TS  A  VVF++LGF A
Sbjct: 234 SGTSFFAGFVVFSILGFMA 252



 Score =  125 bits (315), Expect = 9e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322

Query: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528
                 YP WG  +  +  + ++L VP+
Sbjct: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  198 bits (504), Expect = 1e-50
 Identities = 95/257 (36%), Positives = 144/257 (56%), Gaps = 9/257 (3%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIP+F LE ++GQ   +G +  W  I P   GIG+AS ++   + +YY +++ W+LFY  
Sbjct: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQS---------SATTYYWYREALNISSSISES 114
            SF   LPW  C    N  H     +   S         S    +W R  L IS  I   
Sbjct: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHL 201

Query: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174
           G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+  G
Sbjct: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261

Query: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234
           I+    P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + F+N
Sbjct: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321

Query: 235 FFTSVLATLVVFAVLGF 251
             TS +A   +F++LGF
Sbjct: 322 SGTSFVAGFAIFSILGF 338



 Score =  120 bits (300), Expect = 5e-27
 Identities = 69/213 (32%), Positives = 117/213 (54%), Gaps = 18/213 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383
           A  G GLAFIA+  A+   P SP W+  FF M+V LGL S F  +E +VT +VD +    
Sbjct: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410

Query: 384 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
             K R+E+L +   +++F +GLI +   G Y   +FD Y+A+ + LL V I E++ V +V
Sbjct: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG  +F ++++DM+G+ P     Y W +++P +  +  + S++    +P  YN       
Sbjct: 471 YGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN------- 521

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
             +  +YP WG  +   L + +++ +P   + R
Sbjct: 522 --KKYTYPWWGDALGWLLALSSMVCIPAWSLYR 552


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  198 bits (503), Expect = 1e-50
 Identities = 95/256 (37%), Positives = 149/256 (58%), Gaps = 5/256 (1%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+PLF LE S+GQ    G +GVW  ++P   G+G A+ V+ +++ +YY VII W+++Y  
Sbjct: 94  GVPLFLLECSLGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLY 152

Query: 64  QSFQQPLPWDQCPLVKNASHTF----VEPECEQSSATTYYWYREALNISSSISESGGLNW 119
            SF   LPW QC    N    F    +      +SA   +W R    ++  + + G + W
Sbjct: 153 NSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRW 212

Query: 120 KMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMF 179
            + I L  AW++V   + KG+  +GK++YFS+ +PY++LI    R   L G+ +GI    
Sbjct: 213 PLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272

Query: 180 TPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSV 239
           TP    + + +VW +AATQ+FF+ GLG G +IA  SYN   NN + D+++V  IN  TS+
Sbjct: 273 TPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSM 332

Query: 240 LATLVVFAVLGFKANV 255
            A  V+F+++GF A+V
Sbjct: 333 FAGFVIFSIVGFMAHV 348



 Score =  125 bits (314), Expect = 1e-28
 Identities = 57/163 (34%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383
           A  G GLAF+A+ EA+T  P SP W+++FF ML+ LG+ S F T+EG +T +VD +    
Sbjct: 357 AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLL 416

Query: 384 KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFVYG 442
           + R+E+     C++++ IGL  + + G Y   +FD YSA+ + LL +V  E +++ + YG
Sbjct: 417 RNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYG 476

Query: 443 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNM 485
           +++F +++++M+G  P  ++   W + +P+++  + I S V M
Sbjct: 477 VNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQM 519


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  190 bits (483), Expect = 3e-48
 Identities = 95/264 (35%), Positives = 146/264 (55%), Gaps = 17/264 (6%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           GIP+FFLE ++GQ    G I  W  + P   GIG+A+ V+   + +YY +I+ W++FY S
Sbjct: 100 GIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLS 159

Query: 64  QSFQQPLPWDQCPL--------------VKNASHTFVEPECEQSSATTYYWYREALNISS 109
             F   LPW  C                V N SH  ++     +S    +W    L IS 
Sbjct: 160 NCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQ---NATSPVMEFWEHRVLAISD 216

Query: 110 SISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLN 169
            I   G L W++ +CLLAAW +    + KG +S+GK++Y ++ FPY++L+  LIR   L 
Sbjct: 217 GIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLP 276

Query: 170 GSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVL 229
           G+ +GI+    P L  + +P+VW +A TQ+FF+  +  G + A  SYN  +NNC+ D ++
Sbjct: 277 GASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIM 336

Query: 230 VSFINFFTSVLATLVVFAVLGFKA 253
           +  +N  TS +A   +F+VLGF A
Sbjct: 337 LCCLNSGTSFVAGFAIFSVLGFMA 360



 Score =  121 bits (303), Expect = 2e-27
 Identities = 65/208 (31%), Positives = 115/208 (55%), Gaps = 18/208 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 384
           A  G GLAFIA+ +A+T  P SP W+ +FF+ML+ LGL S F  +E +VT +VD +    
Sbjct: 371 AESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVF 430

Query: 385 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
               R+E+L +   ++++ +GL+ +   G Y   +FD Y+A+ + LL V I E I + +V
Sbjct: 431 RRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWV 490

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG ++F ++++DM+G+ P     + W  ++P +   + I  ++     P  YN       
Sbjct: 491 YGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIK--YKPLKYN------- 541

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528
                +YP WG  +   + + ++L +P+
Sbjct: 542 --NIYTYPAWGYGIGWLMALSSMLCIPL 567


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  188 bits (478), Expect = 1e-47
 Identities = 91/268 (33%), Positives = 149/268 (55%), Gaps = 24/268 (8%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ +Y  
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTY------YWYREAL 105
           QSFQ+ LPW  C      +H++  P C +             S+T +      +W R  L
Sbjct: 151 QSFQKELPWAHC------NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVL 204

Query: 106 NISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRA 165
           ++S  I   G L W + +CLL  W++    + KG++S+GK++YF++ FP+ +L+  L+R 
Sbjct: 205 SLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 264

Query: 166 FLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHF 225
             L G+  GI+    P +  + +P+VW +A TQ+FF+  +  G + +  SYNK   N + 
Sbjct: 265 LTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYR 324

Query: 226 DAVLVSFINFFTSVLATLVVFAVLGFKA 253
           D +L+  +N  TS ++   +F++LGF A
Sbjct: 325 DCMLLGCLNSGTSFVSGFAIFSILGFMA 352



 Score =  127 bits (319), Expect = 3e-29
 Identities = 72/213 (33%), Positives = 115/213 (53%), Gaps = 18/213 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 384
           A  G GLAFIA+ +A+T  P   FWS++FF+ML+ LGL S F  +EG +T +VD +    
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 385 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
               R+EI     C +++ +GL  V   G Y   +FD Y+A+ + LL V   E   + ++
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D   + ++DM+G+ P  +  Y W  I+P++ +   I S+V     P  YN       
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVK--YVPLTYN------- 533

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
             +   YP W + +  SL + ++L VP+V ++R
Sbjct: 534 --KTYVYPNWAIGLGWSLALSSMLCVPLVIVIR 564


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  188 bits (478), Expect = 1e-47
 Identities = 91/268 (33%), Positives = 149/268 (55%), Gaps = 24/268 (8%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ +Y  
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTY------YWYREAL 105
           QSFQ+ LPW  C      +H++  P C +             S+T +      +W R  L
Sbjct: 151 QSFQKELPWAHC------NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVL 204

Query: 106 NISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRA 165
           ++S  I   G L W + +CLL  W++    + KG++S+GK++YF++ FP+ +L+  L+R 
Sbjct: 205 SLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 264

Query: 166 FLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHF 225
             L G+  GI+    P +  + +P+VW +A TQ+FF+  +  G + +  SYNK   N + 
Sbjct: 265 LTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYR 324

Query: 226 DAVLVSFINFFTSVLATLVVFAVLGFKA 253
           D +L+  +N  TS ++   +F++LGF A
Sbjct: 325 DCMLLGCLNSGTSFVSGFAIFSILGFMA 352



 Score =  127 bits (319), Expect = 3e-29
 Identities = 72/213 (33%), Positives = 115/213 (53%), Gaps = 18/213 (8%)

Query: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 384
           A  G GLAFIA+ +A+T  P   FWS++FF+ML+ LGL S F  +EG +T +VD +    
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 385 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440
               R+EI     C +++ +GL  V   G Y   +FD Y+A+ + LL V   E   + ++
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500
           YG D   + ++DM+G+ P  +  Y W  I+P++ +   I S+V     P  YN       
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVK--YVPLTYN------- 533

Query: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533
             +   YP W + +  SL + ++L VP+V ++R
Sbjct: 534 --KTYVYPNWAIGLGWSLALSSMLCVPLVIVIR 564


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 36/91 (39%), Positives = 53/91 (58%), Gaps = 6/91 (6%)

Query: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63
           G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ +Y  
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQSS 94
           QSFQ+ LPW  C      +H++  P C + +
Sbjct: 151 QSFQKELPWAHC------NHSWNTPHCMEDT 175


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.142    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,742,569
Number of Sequences: 37866
Number of extensions: 1007024
Number of successful extensions: 2919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2767
Number of HSP's gapped (non-prelim): 63
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.