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Search of human proteins with 115511036
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115511036 alpha-kinase 3 [Homo sapiens]
(1907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115511036 alpha-kinase 3 [Homo sapiens] 3859 0.0
gi|148596992 heart alpha-kinase [Homo sapiens] 330 6e-90
gi|157785645 SPEG complex locus [Homo sapiens] 79 4e-14
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 70 2e-11
gi|16950625 myosin light chain kinase isoform 8 [Homo sapiens] 69 4e-11
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 69 4e-11
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 69 4e-11
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 69 4e-11
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 69 4e-11
gi|140560917 myomesin 1 isoform b [Homo sapiens] 68 7e-11
gi|140560919 myomesin 1 isoform a [Homo sapiens] 68 7e-11
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 67 1e-10
gi|16950623 myosin light chain kinase isoform 7 [Homo sapiens] 66 4e-10
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 65 6e-10
gi|155969693 myomesin family, member 3 [Homo sapiens] 64 1e-09
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 63 3e-09
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 63 3e-09
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 62 4e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 62 7e-09
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens] 61 9e-09
gi|110349721 titin isoform novex-3 [Homo sapiens] 60 2e-08
gi|110349719 titin isoform N2-A [Homo sapiens] 60 2e-08
gi|110349717 titin isoform novex-2 [Homo sapiens] 60 2e-08
gi|110349713 titin isoform novex-1 [Homo sapiens] 60 2e-08
gi|110349715 titin isoform N2-B [Homo sapiens] 60 2e-08
gi|153792294 myopalladin [Homo sapiens] 60 2e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 59 5e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 59 5e-08
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 59 6e-08
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 59 6e-08
>gi|115511036 alpha-kinase 3 [Homo sapiens]
Length = 1907
Score = 3859 bits (10007), Expect = 0.0
Identities = 1907/1907 (100%), Positives = 1907/1907 (100%)
Query: 1 MEVAWLVYVLGQQPLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPARPRG 60
MEVAWLVYVLGQQPLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPARPRG
Sbjct: 1 MEVAWLVYVLGQQPLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPARPRG 60
Query: 61 PLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLG 120
PLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLG
Sbjct: 61 PLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLG 120
Query: 121 AGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPG 180
AGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPG
Sbjct: 121 AGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPG 180
Query: 181 AGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASRS 240
AGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASRS
Sbjct: 181 AGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASRS 240
Query: 241 YLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTC 300
YLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTC
Sbjct: 241 YLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTC 300
Query: 301 IVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
IVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSK
Sbjct: 301 IVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
Query: 361 GIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSP 420
GIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSP
Sbjct: 361 GIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSP 420
Query: 421 DRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNG 480
DRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNG
Sbjct: 421 DRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNG 480
Query: 481 EAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQS 540
EAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQS
Sbjct: 481 EAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQS 540
Query: 541 RRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDK 600
RRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDK
Sbjct: 541 RRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDK 600
Query: 601 AQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEG 660
AQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEG
Sbjct: 601 AQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEG 660
Query: 661 VPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPP 720
VPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPP
Sbjct: 661 VPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPP 720
Query: 721 QASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVST 780
QASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVST
Sbjct: 721 QASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVST 780
Query: 781 SGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRK 840
SGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRK
Sbjct: 781 SGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRK 840
Query: 841 TQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRM 900
TQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRM
Sbjct: 841 TQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRM 900
Query: 901 QGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQ 960
QGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQ
Sbjct: 901 QGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQ 960
Query: 961 TPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERC 1020
TPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERC
Sbjct: 961 TPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERC 1020
Query: 1021 RGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTAS 1080
RGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTAS
Sbjct: 1021 RGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTAS 1080
Query: 1081 PKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQ 1140
PKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQ
Sbjct: 1081 PKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQ 1140
Query: 1141 VPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLT 1200
VPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLT
Sbjct: 1141 VPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLT 1200
Query: 1201 PTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAA 1260
PTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAA
Sbjct: 1201 PTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAA 1260
Query: 1261 RGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEA 1320
RGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEA
Sbjct: 1261 RGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEA 1320
Query: 1321 GGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDG 1380
GGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDG
Sbjct: 1321 GGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDG 1380
Query: 1381 EATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDL 1440
EATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDL
Sbjct: 1381 EATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDL 1440
Query: 1441 GPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQF 1500
GPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQF
Sbjct: 1441 GPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQF 1500
Query: 1501 FNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTD 1560
FNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTD
Sbjct: 1501 FNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTD 1560
Query: 1561 FCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEELRGGGYGC 1620
FCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEELRGGGYGC
Sbjct: 1561 FCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEELRGGGYGC 1620
Query: 1621 GLRKASQAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLVGRNYDVTIQGCKIQNMS 1680
GLRKASQAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLVGRNYDVTIQGCKIQNMS
Sbjct: 1621 GLRKASQAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLVGRNYDVTIQGCKIQNMS 1680
Query: 1681 REYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEEDLGKPLESYCSREWGCA 1740
REYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEEDLGKPLESYCSREWGCA
Sbjct: 1681 REYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEEDLGKPLESYCSREWGCA 1740
Query: 1741 EAPTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATKLRGYQGLKES 1800
EAPTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATKLRGYQGLKES
Sbjct: 1741 EAPTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATKLRGYQGLKES 1800
Query: 1801 CFPALLDRFASSHQCNAYCELLGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQPQK 1860
CFPALLDRFASSHQCNAYCELLGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQPQK
Sbjct: 1801 CFPALLDRFASSHQCNAYCELLGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQPQK 1860
Query: 1861 KGLPSPQGTRKSAPSSKATPQASEPVTTQLLGQPPTQEEGSKAQGMR 1907
KGLPSPQGTRKSAPSSKATPQASEPVTTQLLGQPPTQEEGSKAQGMR
Sbjct: 1861 KGLPSPQGTRKSAPSSKATPQASEPVTTQLLGQPPTQEEGSKAQGMR 1907
>gi|148596992 heart alpha-kinase [Homo sapiens]
Length = 2170
Score = 330 bits (847), Expect = 6e-90
Identities = 199/509 (39%), Positives = 286/509 (56%), Gaps = 20/509 (3%)
Query: 1365 ARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKAS 1424
A++ R K A G++ P + T S RK PGS G + R A+
Sbjct: 1681 AKKSREREKSLEARAGKS--PGTLTAVTGSEEVKRKPEAPGS-GHLAEGVKKKILSRVAA 1737
Query: 1425 MLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRV 1484
L + E+E + K L+T ++ E KQ+ K K +AP +++KI+
Sbjct: 1738 -LRLKLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDP--KKPSCKREGRAPVLLKKIQA 1794
Query: 1485 EQFPDASGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCG 1544
E FP+ SG++KL CQF I DS + W KD + + +V RSAGD + AIVQASP D G
Sbjct: 1795 EMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQG 1854
Query: 1545 VYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKL 1604
+Y C I N +G + +F L+ EVL SR++ + EEIE + ++F + +G +L
Sbjct: 1855 LYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRL 1914
Query: 1605 FGRLVSEELRGGGYGCGL-RKASQAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLV 1663
G++ +EEL +G G+ RKA ++ V++GL P+F+ G C++KV + + +G + L+
Sbjct: 1915 RGQIATEELH---FGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELI 1971
Query: 1664 GRNYDVTIQGCKIQNMSREYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEE 1723
RNY + Q C +QN +R Y KI+AAEA+ GFGEVPEIIP++LI+RP NNIPYAT+EE
Sbjct: 1972 QRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEE 2031
Query: 1724 DLGKPLESYCSREWGCAEAPTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMT 1783
+L Y R+ E SEA QKC TFQHW+YQ T+G LVTD+ GV K+T
Sbjct: 2032 ELIGEFVKYSIRDG--KEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLT 2089
Query: 1784 DVQIATKLRGYQGLKESCFPALLDRFASSHQCNAYCELLGLTPLKGPEAAHPQAKAKGSK 1843
DV IAT +GY+G K +C +D+F + HQCN YC++LGL L Q + K
Sbjct: 2090 DVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSL--------QNNNQKQK 2141
Query: 1844 SPSAGRKGSQLSPQPQKKGLPSPQGTRKS 1872
PS G+ Q + KK P G +K+
Sbjct: 2142 QPSIGKSKVQTNSMTIKKAGPETPGEKKT 2170
Score = 80.9 bits (198), Expect = 1e-14
Identities = 41/96 (42%), Positives = 56/96 (58%)
Query: 281 FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQ 340
F +TL S+ V E SD CI++G P+PEVTWYK+ +D + YE H L
Sbjct: 14 FLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLH 73
Query: 341 LYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
L C + DAA+YQ SA+NS G++ CS +EV +E
Sbjct: 74 LSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSE 109
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 79.0 bits (193), Expect = 4e-14
Identities = 93/313 (29%), Positives = 120/313 (38%), Gaps = 66/313 (21%)
Query: 97 PRPPG--PLQTRRYCRHQGRQGSGLGAGPGAGTWAPAP---PGVSKPRCP-GRARPGEGQ 150
PR PG PL +R R S A P + + A P PG + R P GR PGEG
Sbjct: 527 PREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGP 586
Query: 151 QQ---------------VTTARPPAINRGARQPRAGAAAAG---RGPGAGA-----WRTG 187
QQ + R P A P A A R P A A W T
Sbjct: 587 QQEVRRRDQFPLTRSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWATP 646
Query: 188 EAAASAGPAVGEGGAMGS------RRAPSRG--WGAGGRSGAGGDGEDDGPVWIPSPASR 239
+A P E G RR P WG R GA G+
Sbjct: 647 GLEGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGR----------- 695
Query: 240 SYLLSVRPET-SLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRF 298
RP + L S+ S+ S+G P+FE L++ V+ +DV
Sbjct: 696 ----RARPTSPELESSDDSYVSAGEEPL----------EAPVFEIPLQNVVVAPGADVLL 741
Query: 299 TCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQN 358
CI+T P P+V+W+KD + L R G + + +G RHTL L R DA Y A+A N
Sbjct: 742 KCIITANPPPQVSWHKDGSAL-RSEG--RLLLRAEGERHTLLLREARAADAGSYMATATN 798
Query: 359 SKGIVSCSGVLEV 371
G +C+ L V
Sbjct: 799 ELGQATCAASLTV 811
Score = 71.6 bits (174), Expect = 7e-12
Identities = 178/793 (22%), Positives = 279/793 (35%), Gaps = 133/793 (16%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P+F LK+ +V SDVR +V+G P+P + W++D L P
Sbjct: 43 PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPS----------C 92
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREI 398
L L RC +DA +Y AQN +G SC VL V + + + + + ++ +LR+
Sbjct: 93 LWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDDISDVQGTQRLELRDD 152
Query: 399 EQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETE 458
G DTL S D P SV E ++ W G+T
Sbjct: 153 GAF----STPTGGSDTLVGTSLD------------TPPTSVTGTSEE--QVSWWGSGQTV 194
Query: 459 TAQHSGLG-----LINSFASGEVTTNGE-----------------AAPENGEDGEHGLLT 496
Q +G G L S + T G A ED
Sbjct: 195 LEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASD 254
Query: 497 YICDAMELGPQRALK-----EESGAKKKKKD------EESKQGLRKPELEKAA----QSR 541
A L RAL +SG ++++ D E+ + +P K+A S
Sbjct: 255 LYGSAFSLYRGRALSIHVSVPQSGLRREEPDLQPQLASEAPRRPAQPPPSKSALLPPPSP 314
Query: 542 RSSENCIPSSDEPDSC-------GTQGPVGVEQVQT-QPRGRAAR--GPGSSGTDSTRKP 591
R + P + TQ PV E T + RG+ ++ GP +GT +R P
Sbjct: 315 RVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESR-P 373
Query: 592 ASAVGTPDKAQKAPGPGP-----GQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGE 646
+ + A G P G + L+ + E + + P L P
Sbjct: 374 QTPLSEASGRLSALGRSPRLVRAGSRILDKLQ--FFEERRRSLERSDSPPAPLRPWVP-- 429
Query: 647 SPKGKAPLRARSE-GVP-GAPGQPTHSLTPQPTRPFNRKRFAPPKPKG--EATTDSKPIS 702
K ++ + +SE G P G PG L P R+R K E T P S
Sbjct: 430 LRKARSLEQPKSERGAPWGTPGASQEELR-APGSVAERRRLFQQKAASLDERTRQRSPAS 488
Query: 703 SLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTA 762
L AQ LG+ S + R H + +TLQ R PGE
Sbjct: 489 DLELR---FAQELGRIRRSTSRE----ELVRSHESLRATLQRAPSPREPGE--------- 532
Query: 763 PTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRT-GSKKNVQADGKIQVD 821
P + + S+ S VS + +Q P ++ G R+ G + Q +
Sbjct: 533 PPLFSRPSTPKTSRAVSPAAAQ---PPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQE 589
Query: 822 GRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAET---------Q 872
R R T R+RA ++ + + P++ A G + A+
Sbjct: 590 VRRRDQFPLT--RSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWATPG 647
Query: 873 LETTQAGEKIQEDRKA-QADKGTQEDRRMQGEKGMQGEKGTQSEG----SAPTAMEGQSE 927
LE + ++++R +A+K + G G +G +S+G + PT+ E +S
Sbjct: 648 LEGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGRRARPTSPELESS 707
Query: 928 QEVATSLG------PPSRTPKLPPTAGPRAPLNIECFV-QTPEGSCFPKKPGCLPRSEEA 980
+ S G P P P A + ++C + P K G RSE
Sbjct: 708 DDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGR 767
Query: 981 VVTASRNHEQTVL 993
++ + T+L
Sbjct: 768 LLLRAEGERHTLL 780
Score = 56.2 bits (134), Expect = 3e-07
Identities = 32/105 (30%), Positives = 49/105 (46%), Gaps = 5/105 (4%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CS+ +L E P FE+ ++ V RF +V G P P++ WYKD+ L +
Sbjct: 1475 CSVTLELAEA--PRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHV- 1531
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
++ N +L + +D +Y +AQN G VSC L V
Sbjct: 1532 --SFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAV 1574
Score = 51.2 bits (121), Expect = 9e-06
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 3/105 (2%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CS + PLF L+ V E RF C ++G P P VTW ++ L
Sbjct: 1052 CSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENL- 1110
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ G H+L + ED +Y SA N+ G CS L V
Sbjct: 1111 --RLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYV 1153
Score = 40.4 bits (93), Expect = 0.017
Identities = 73/329 (22%), Positives = 115/329 (34%), Gaps = 47/329 (14%)
Query: 79 SSTKGPVLHDQDTRCAFLPRPPG-PLQ-TRRYCRHQGRQGSGLGAGPG---------AGT 127
S +GP ++ + P P G PL+ RR R + Q PG +
Sbjct: 2357 SEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAVGEPGLVRRLSLSLSQR 2416
Query: 128 WAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAI------------NRGARQPRAGAA-- 173
PP P R GE + ++AR + +R R+G++
Sbjct: 2417 LRRTPPAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFTLERLSSRLQRSGSSED 2476
Query: 174 ---AAGRG-PGAGAWRT----GEAAASAGPAVGEGGAMGSRRAPSR---GWGAGGRSGAG 222
A+GR P G R GE+ G + A PS G A SG+
Sbjct: 2477 SGGASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQAGATTPSAESLGSEASATSGSS 2536
Query: 223 GDGEDDGPVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFE 282
GE + R R + LS LS +S + + + P+F
Sbjct: 2537 APGESRSRL-------RWGFSRPRKDKGLSPPNLS--ASVQEELGHQYVRSESDFPPVFH 2587
Query: 283 TTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLY 342
LK + + E C+ P P ++W KD L + ++ + R L +
Sbjct: 2588 IKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSV--IIVSCKDGRQLLSIP 2645
Query: 343 RCREEDAAIYQASAQNSKGIVSCSGVLEV 371
R + A +Y+ SA N G ++ S + V
Sbjct: 2646 RAGKRHAGLYECSATNVLGSITSSCTVAV 2674
Score = 40.0 bits (92), Expect = 0.022
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 2/93 (2%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F+ +L +SV E DV + V G P+P V+W ++ + ++ +G
Sbjct: 869 PTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRP--DQRRFAEEAEGGLCR 926
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L++ DA Y A N G C LEV
Sbjct: 927 LRILAAERGDAGFYTCKAVNEYGARQCEARLEV 959
Score = 39.3 bits (90), Expect = 0.037
Identities = 55/233 (23%), Positives = 89/233 (38%), Gaps = 33/233 (14%)
Query: 853 PQSDRSAQKGM-MTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKG 911
P +R QK +QG AE + +AG ++ + QE + + +
Sbjct: 2119 PLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALS--EAQPS 2176
Query: 912 TQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFP--- 968
+ + SAP +S + AT+ PS P+ PP P + PE P
Sbjct: 2177 SPARPSAPKPSTPKSAEPSATT---PSDAPQ-PPAPQPAQD-------KAPEPRPEPVRA 2225
Query: 969 KKPGCLPRSEEAVVTASRNHEQTVLG-PLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSG 1027
KP P++ + + + Q + LSG+ P+Q P E P+
Sbjct: 2226 SKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSE---------PKPHA 2276
Query: 1028 PVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTAS 1080
V A+ P P++ P GG P+ VPT+P PG+ L++S
Sbjct: 2277 AVFARVASPPPGAPEKRVPSA------GGPPVLAEKARVPTVPPRPGSSLSSS 2323
Score = 35.4 bits (80), Expect = 0.54
Identities = 60/249 (24%), Positives = 81/249 (32%), Gaps = 63/249 (25%)
Query: 528 GLRKPELEKAA-------QSRRSSENCIPSSDEP-DSCGTQGPVGVEQVQTQPRGRAARG 579
GLR P LE +R +S P P ++ G Q Q + +PRGR R
Sbjct: 2086 GLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRA 2145
Query: 580 -----------------------------PGSSGTDSTRKPAS------AVGTPDKAQKA 604
P S S KP++ + TP A +
Sbjct: 2146 GAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQP 2205
Query: 605 PGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGA 664
P P P Q+ + E +A +P PQ L A +P + + G
Sbjct: 2206 PAPQPAQD---KAPEPRPEPVRASKP--APPPQALQTLALPLTPYAQIIQSLQLSGHAQG 2260
Query: 665 PGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQA-S 723
P Q P P P +PK A ++ S APE S G P A
Sbjct: 2261 PSQ-------GPAAP-------PSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPVLAEK 2306
Query: 724 VQVPTPPAR 732
+VPT P R
Sbjct: 2307 ARVPTVPPR 2315
Score = 32.7 bits (73), Expect = 3.5
Identities = 46/172 (26%), Positives = 64/172 (37%), Gaps = 27/172 (15%)
Query: 142 GRARPGEGQQQVTTARPPAINRGARQPRAGAA-----AAGRGPGAGAWRTGEAAASAGPA 196
G A P + Q+Q R P+ ++ A P A + AAG P G R G +A SA P
Sbjct: 1966 GAATPMDWQEQ---GRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPR 2022
Query: 197 VGE-----------GGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASRSYLLSV 245
G + RR+PS G R G G +G A R LL
Sbjct: 2023 AGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLG-----EGEYAQRLQALRQRLLRG 2077
Query: 246 RPETSLSS---NRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDS 294
PE S L GR+ + + E P + L++R + + S
Sbjct: 2078 GPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSS 2129
Score = 32.3 bits (72), Expect = 4.5
Identities = 45/162 (27%), Positives = 62/162 (38%), Gaps = 24/162 (14%)
Query: 621 YLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPF 680
+ +++ V G + + A E+P P RAR P PT SL P P P
Sbjct: 2759 FSNSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARAR------PPDSPT-SLAP-PLAP- 2809
Query: 681 NRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRR--HGTR 738
A P P + S P + SQA +++G PPQ TPP R R R
Sbjct: 2810 -----AAPTPPSVTVSPSSPPTPPSQALS-SLKAVG-PPPQ------TPPRRHRGLQAAR 2856
Query: 739 DSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVST 780
+ + H TP E T + AS+ V + ST
Sbjct: 2857 PAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSSST 2898
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 2/74 (2%)
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F C+V G + EV W L L K ++ G + L L E+D+ +Y
Sbjct: 987 FECLVAGPTDVEVDWLCRGRLLQP--ALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLS 1044
Query: 358 NSKGIVSCSGVLEV 371
+K ++CS L V
Sbjct: 1045 TAKDELTCSARLTV 1058
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 70.1 bits (170), Expect = 2e-11
Identities = 141/694 (20%), Positives = 245/694 (35%), Gaps = 86/694 (12%)
Query: 443 EPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAM 502
E EG +A +EG+T ++ S + GE GE E GE G G
Sbjct: 1762 EAEGDAMAQEREGKTHNSETSAGSEL-----GEAEQEGEGISERGETGGQGS-------- 1808
Query: 503 ELGPQRALKEES--GAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQ 560
G + L+ E+ G + + +G+ PE E AQ P S+ ++ +
Sbjct: 1809 --GHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ---------PESEGVEAPEAE 1857
Query: 561 GPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDM 620
G + + QP P + G + + V TP+ + G E + K+
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEG--EAQPESEDVETPEAEWEVQPESEGAEAPEAEKEA 1915
Query: 621 Y--LENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTR 678
E+ +A+ GE+ P++ A + E A GQ T+
Sbjct: 1916 QPETESVEALETEGEDEPESEGAEA-----------QEAEEAAQEAEGQ---------TQ 1955
Query: 679 PFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQAS-VQVPTPPARRRHGT 737
P + + + EA +S+ + +L E ++ G+A P++ V+ P +
Sbjct: 1956 P-ESEVIESQEAEEEAQPESEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAE 2013
Query: 738 RDSTLQGQAGHRTP-GEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQE 796
++ + P E E Q T + S GV ++ + + E QE
Sbjct: 2014 EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073
Query: 797 DGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSD 856
A+ + +A+G+ Q + +G + + +K + + Q +
Sbjct: 2074 -AEGEAHPESEDVDAQEAEGEAQPES----EGVEAPEAEGEAQKAEGIEAPETEGEAQPE 2128
Query: 857 RSAQKGMMTQGRAETQLETTQA----GEKIQEDRKAQADKGTQEDR-RMQGEKG--MQGE 909
+ +G A+ + E +A GE E +A + +E + ++G + +GE
Sbjct: 2129 SEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188
Query: 910 KGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPK 969
+SEG EG+++ E+ P + P G P EG +
Sbjct: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGE 2248
Query: 970 KPGCLP------RSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGP 1023
K G +SEEA ++S E P S PH+ Q G R
Sbjct: 2249 KKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPG----GDTPHQRPGSQTGPSSSRA- 2303
Query: 1024 QSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKA 1083
S G K ++ P G P A E P + T+ +
Sbjct: 2304 SSWGNCWQKDSENDHVLGDTRSPDA----KSTGTPHA----ERKATRMYPESS-TSEQEE 2354
Query: 1084 GPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLG 1117
P + T + G++ + EDQ L S APT +G
Sbjct: 2355 APLGSRTPEQGASEGYDLQEDQALGSLAPTEAVG 2388
Score = 64.3 bits (155), Expect = 1e-09
Identities = 168/757 (22%), Positives = 250/757 (33%), Gaps = 119/757 (15%)
Query: 695 TTDSKPISSLSQAPECGAQSLGK--APPQASVQV---PTPPARRRHGTR---------DS 740
T + +P S + + G ++ G+ P +A V+ P P TR
Sbjct: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQ 1691
Query: 741 TLQGQAGHRTPGEVLEC---QTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQED 797
LQ + G T GE E +T T PT + + +G S G+ E ED
Sbjct: 1692 ILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEG------ED 1745
Query: 798 GRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDR 857
G S + N D K+ G GD +R ++ AG++ +
Sbjct: 1746 GEGS------QRLNRDKDPKL---GEAEGDA-MAQEREGKTHNSETSAGSELGE------ 1789
Query: 858 SAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGS 917
+ Q+G R ET + + + +Q + A D+ + +G + + E Q E
Sbjct: 1790 AEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESE 1849
Query: 918 APTAMEGQSE-QEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPR 976
A E + + QE P S + P G P + + V+TPE + P
Sbjct: 1850 GVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESED--VETPEAEWEVQ-----PE 1902
Query: 977 SEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDS 1036
SE A + Q P SVE + E P+S G + E++
Sbjct: 1903 SEGAEAPEAEKEAQ----------------PETESVEALETEGEDEPESEGAEAQEAEEA 1946
Query: 1037 PFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGST 1096
+ + +P Q A E + A +A P S +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006
Query: 1097 ATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDP 1156
+E++ S G Q SEG AQ +VEG T
Sbjct: 2007 GEMQEAEEEAQPESD-------GVEAQP--------KSEGEEAQ--EVEGETQKTEGDAQ 2049
Query: 1157 GLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRI 1216
D ++ E E +V A G P + E G + S +
Sbjct: 2050 PESDGVE--------APEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGV 2101
Query: 1217 LERVENNHLVQSAQTLLL-------SPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPS 1269
E E Q A+ + P + + E Q + + A P
Sbjct: 2102 -EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE 2160
Query: 1270 SLTVPAIVVDEE-DPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQ 1328
S + A +EE P L A E EGE PE G+ E GEA + +
Sbjct: 2161 SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE-------GEAQPELEGVE 2213
Query: 1329 GPSAESIAQ-EPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEAT---- 1383
P AE AQ EP E E A PE K+ P+V + GDG++
Sbjct: 2214 APEAEEEAQPEPEGVETPEAEG-----EAQPESEGETQGEKKGSPQV-SLGDGQSEEASE 2267
Query: 1384 ----TPEERESPTVSPRGPRKSLVPGSPGTPGRERRS 1416
PE+R +P SP G PGS P R S
Sbjct: 2268 SSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
Score = 55.5 bits (132), Expect = 5e-07
Identities = 142/689 (20%), Positives = 236/689 (34%), Gaps = 120/689 (17%)
Query: 102 PLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAI 161
P TR +G G GL GPG GEG Q++ + P +
Sbjct: 1717 PTSTRTVQGAEGGLGPGLSQGPGV----------------DEGEDGEGSQRLNRDKDPKL 1760
Query: 162 NRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMG---SRRAPSRGWGAG-- 216
G A A G +T + SAG +GE G S R + G G+G
Sbjct: 1761 GEA-----EGDAMAQEREG----KTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHE 1811
Query: 217 ----GRSGAGGD---GEDDGPVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSI 269
G + AGGD G+ DG I +P + +PE S + + G +
Sbjct: 1812 DNLQGEAAAGGDQDPGQSDGAEGIEAPEAEG---EAQPE---SEGVEAPEAEGDAQEAEG 1865
Query: 270 IAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
AQ E E +++ SED + PE W + P+ E
Sbjct: 1866 EAQPESEDVEAPEAEGEAQPESEDVET-----------PEAEW--EVQPESEGAEAPEAE 1912
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKR 389
Q +++ ED ++ ++ + E T E ++ + A+
Sbjct: 1913 KEAQPETESVEALETEGEDEP--ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAE--- 1967
Query: 390 KAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTRE---PEG 446
E + + +A+ EV+T ++ + + +A G E PE
Sbjct: 1968 ------EEAQPESEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPES 2020
Query: 447 GTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGP 506
+ A + E E AQ + + ++G APE E+ + E P
Sbjct: 2021 DGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
Query: 507 QRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSD---EPDSCGTQGPV 563
+ + A+ + + E +G+ PE E AQ E P ++ +P+S G + P
Sbjct: 2081 ESEDVDAQEAEGEAQPE--SEGVEAPEAEGEAQKAEGIE--APETEGEAQPESEGIEAPE 2136
Query: 564 GVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLE 623
+ Q + G A+ + +P S +A++ P LE
Sbjct: 2137 AEGEAQPESEGVEAQ-----DAEGEAQPESEGIEAQEAEEEAQP-------------ELE 2178
Query: 624 NTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRK 683
+A GE P++ + E+P+ + + EGV + P+ +
Sbjct: 2179 GVEAPEAEGEAQPESEGI----EAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE 2234
Query: 684 RFAPPKPKGEATTDSK--PISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDST 741
A P+ +GE + K P SL A P+ PTPP +
Sbjct: 2235 GEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE---DRPTPP---------PS 2282
Query: 742 LQGQAGHRTPGEVLECQTTTAPTMSASSS 770
G H+ PG + T P+ S +SS
Sbjct: 2283 PGGDTPHQRPG------SQTGPSSSRASS 2305
Score = 43.9 bits (102), Expect = 0.002
Identities = 156/732 (21%), Positives = 254/732 (34%), Gaps = 163/732 (22%)
Query: 806 TGSKKNVQADGKIQVDGRTRGDGTQTAQRT---RADRKTQVDAGTQESKRP--------- 853
+GS + ++ +DG GT+ +T R D +T G E+++
Sbjct: 1205 SGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNA 1264
Query: 854 ----------QSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQED----RR 899
+++R +++ + + T Q +++E ++ +G QE+
Sbjct: 1265 RACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEE 1324
Query: 900 MQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAG---PRAPLNIE 956
+ E+G+Q E+G Q E + T EGQ E+E ++ ++ T G + +E
Sbjct: 1325 TKTEEGLQ-EEGVQLEETKETEGEGQQEEE--------AQLEEIEETGGEGLQEEGVQLE 1375
Query: 957 CFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVG 1016
+ PEG EA+ + P EGSV
Sbjct: 1376 EVKEGPEGGL----------QGEALEEGLKEEGL----------------PEEGSVHGQE 1409
Query: 1017 GERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTG 1076
P G QED P Q E G CP G + L T
Sbjct: 1410 LSEASSPDGKG----SQEDDPVQ----EEEAGRASASAEPCPAEGTEEPTEPPSHLSETD 1461
Query: 1077 LTASPK-AGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMA-TSS 1134
+AS + +G P + AT + E TQ+ P + A SS
Sbjct: 1462 PSASERQSGSQLEPGLEKPPGATMMGQEH-----------------TQAQPTQGAAERSS 1504
Query: 1135 EGACAQVPDVEGRTPGPRSCDPGLIDSL--KNYLLLLLKLSSTETSGAGGESQVGAATGG 1192
AC+ D CDP + L K L L+S + A ++ G
Sbjct: 1505 SVACSAALD----------CDPIWVSVLLKKTEKAFLAHLAS---AVAELRARWGLQDND 1551
Query: 1193 LVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQA 1252
L+ +VA +++R L++++ A ++L P LTG L + Q
Sbjct: 1552 LLDQMAAELQQDVAQRLQDSTKRELQKLQGR-----AGRMVLEP-PREALTGELLLQTQQ 1605
Query: 1253 GRQALAAARG-------SWGPGPSSLTVPAIVVDEEDPGLA----SEGASEGEGE----- 1296
R L R + G GP S T+ E++P L+ S+ E EGE
Sbjct: 1606 RRHRLRGLRNLSAFSERTLGLGPLSFTL------EDEPALSTALGSQLGEEAEGEEFCPC 1659
Query: 1297 -------VSPEGP-GLLGASQ---------ESSMAGRLGE----AGGQAAPGQGPSAESI 1335
VSP P +GA++ + + + GE + APG+ + +
Sbjct: 1660 EACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTS 1719
Query: 1336 AQEPSQEEKFPGEALTGLPAATPEELALGARR--KRFLPKVRAAGDGEATTPEERESPTV 1393
+ E G L+ P E G++R + PK+ A +G+A E
Sbjct: 1720 TRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEA-EGDAMAQEREGKTHN 1778
Query: 1394 SPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAG---DLGPSPKAGGLD 1450
S L G R T G+ + + E AAG D G S A G++
Sbjct: 1779 SETSAGSELGEAEQEGEGISERGETGGQGSG--HEDNLQGEAAAGGDQDPGQSDGAEGIE 1836
Query: 1451 TEVALDEGKQET 1462
A E + E+
Sbjct: 1837 APEAEGEAQPES 1848
Score = 41.6 bits (96), Expect = 0.007
Identities = 76/326 (23%), Positives = 120/326 (36%), Gaps = 44/326 (13%)
Query: 1186 VGAATGGLVPSATLTPTVEVAGLSPRTSRRI-------LERVENNHLVQSAQTLLLSPCT 1238
V A GGL P + P V+ G S+R+ L E + + Q + + T
Sbjct: 1723 VQGAEGGLGPGLSQGPGVD-EGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET 1781
Query: 1239 SRRLTGLLDREVQAGRQALAAARGSWGPG-PSSLTVPAIVVDEEDPGLA--SEG--ASEG 1293
S + L + E + + G G G +L A ++DPG + +EG A E
Sbjct: 1782 SAG-SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEA 1840
Query: 1294 EGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFP------- 1346
EGE PE G+ E GEA ++ + P AE AQ S++ + P
Sbjct: 1841 EGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ 1900
Query: 1347 -----GEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEER----------ESP 1391
EA A PE ++ A + + G EA EE ES
Sbjct: 1901 PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEG-AEAQEAEEAAQEAEGQTQPESE 1959
Query: 1392 TVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASM------LEVPRAEEELAAGDLGPSPK 1445
+ + + P S E TQ + +E P AE E+ + P+
Sbjct: 1960 VIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE 2019
Query: 1446 AGGLDTEVALD-EGKQETLAKPRKAK 1470
+ G++ + + E QE + +K +
Sbjct: 2020 SDGVEAQPKSEGEEAQEVEGETQKTE 2045
Score = 37.4 bits (85), Expect = 0.14
Identities = 43/178 (24%), Positives = 58/178 (32%), Gaps = 3/178 (1%)
Query: 1268 PSSLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPG 1327
P S V A + E A E EGE PE G+ E Q A G
Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEG 2155
Query: 1328 QG-PSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPE 1386
+ P +E I + ++EE P L G+ A E A P+ E E
Sbjct: 2156 EAQPESEGIEAQEAEEEAQP--ELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
Query: 1387 ERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSP 1444
E+ + P P + G E TQG K +V + + SP
Sbjct: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSP 2271
Score = 35.4 bits (80), Expect = 0.54
Identities = 80/351 (22%), Positives = 116/351 (33%), Gaps = 54/351 (15%)
Query: 414 TLRKLSPDRFQRKRRLSGAQAP---GPSVPTREPEGGTLAAWQEGETETAQHSGLG---- 466
++ K P +R+R P G S TR G L G + G
Sbjct: 681 SVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATV 740
Query: 467 ---LINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALK-EESGAKKKKKD 522
+ + F SG N AP G G+ G T C + P + +SGA ++
Sbjct: 741 TPAVHSDFVSGVSPHN---APSAGWAGDAGSRT--CSPAPIPPHTSDSCSKSGAASLGEE 795
Query: 523 EESKQGLRKPEL------EKAAQSRRSSENCIPSSDEPDSCGTQGP------VGVEQVQT 570
P + E+ A S C +P +GP + T
Sbjct: 796 ARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPT 855
Query: 571 QPRGRA-----ARGPGSSGTDSTRKPASAVGTPDKAQKAPG--PGPGQEVYFSLKDMYLE 623
PRGR + GS+G+ G+P + + PG P PG S + +
Sbjct: 856 PPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQ 915
Query: 624 NTQAVRPLGEE-------GPQTLSVRAPGESPKG------KAPLRARSEGVPGAPGQPTH 670
+ R L EE GPQ A G SP +A +R + +P P T+
Sbjct: 916 GAGS-RGLSEEKTLRSGGGPQG-QEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTY 973
Query: 671 SLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQ 721
L + T P G D + L + + G QSL P Q
Sbjct: 974 ELADETTGAAGGGLRGPEVDPG----DDHSLEGLGEPAQAGQQSLEGDPGQ 1020
Score = 34.7 bits (78), Expect = 0.92
Identities = 141/658 (21%), Positives = 222/658 (33%), Gaps = 135/658 (20%)
Query: 770 SSDVASIGVSTSGSQGIIEPMDM---ETQEDGRTSANQRTGSKKNVQADGKIQ------V 820
S D AS ST +G EP T EDG SA+ +A G + +
Sbjct: 449 SQDSASPASSTGLPEGS-EPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCI 507
Query: 821 DGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQG-----RAET-QLE 874
DG G Q + T R + + + + S++ G QG RAET Q E
Sbjct: 508 DGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQE 567
Query: 875 TTQAGEKIQEDRKAQADKGT--QEDRRMQGEKGMQGEKGTQ------------SEGSAPT 920
++ G+ + + Q + + QG + G T+ SEG++ T
Sbjct: 568 ASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASST 627
Query: 921 AMEGQSEQEV-------ATSLGPPSRTP--KLPPTAGPR---------APLNIECFVQTP 962
S Q+ A+++ PS ++ P PR +PL+ Q P
Sbjct: 628 PSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVP 687
Query: 963 EGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRG 1022
+ P ++ V + SGNL +PP GS+ + G
Sbjct: 688 ------RPPERRRACQDGSVPRYSGSSSSTRTQASGNL----RPPSSGSLPS---QDLLG 734
Query: 1023 PQSSGPVEAKQED-----SPFQCPKEE----------RPGGVPCMDQGGCPLAG---LSQ 1064
S+ A D SP P P +P C +G L +
Sbjct: 735 TSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGE 794
Query: 1065 EV-----PTMPSLPGTGLTASPKAGP-----CSTPTSQHGSTATFLPSEDQVLMSS--AP 1112
E P+ P + G GP CS P +Q A PS + + P
Sbjct: 795 EARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCP 854
Query: 1113 TLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKL 1172
T G P + SS + A+ P G +P + PG S +
Sbjct: 855 TPPRGRPCPQRRSSSCGSTGSSHQSTARGP---GGSPQEGTRQPGPTPSPGPNSGASRRS 911
Query: 1173 SSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSP----RTS-----RRILERVENN 1223
S+++ +G+ G S+ G P E +G+SP R+S R L+ +
Sbjct: 912 SASQGAGSRGLSEEKTLRSGGGPQGQ----EEASGVSPSSLPRSSPEAVVREWLDNIPEE 967
Query: 1224 HLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDP 1283
++ + + L T GL EV G G +P
Sbjct: 968 PILMTYE--LADETTGAAGGGLRGPEVDPGDDHSLEGLG-------------------EP 1006
Query: 1284 GLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQ 1341
A + + EG+ PE G L S ++ G G+ P QG + E +++ P++
Sbjct: 1007 AQAGQQSLEGDPGQDPEPEGALLGSSDT------GPQSGEGVP-QGAAPEGVSEAPAE 1057
Score = 34.7 bits (78), Expect = 0.92
Identities = 47/192 (24%), Positives = 64/192 (33%), Gaps = 15/192 (7%)
Query: 1280 EEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLG----EAGGQAAPG----QGPS 1331
E P A E EGE PE G+ E G E G+A P + P
Sbjct: 2077 EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPE 2136
Query: 1332 AESIAQEPSQEEKFPGEALTGLPAATPEELALGAR--RKRFLPKVRAAGDGEATTPEERE 1389
AE AQ S+ EA A PE + A+ + P++ EA + E
Sbjct: 2137 AEGEAQPESEGV----EAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192
Query: 1390 SPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGL 1449
S + P G E Q +E P AE E G +
Sbjct: 2193 SEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEG-VETPEAEGEAQPESEGETQGEKKG 2251
Query: 1450 DTEVALDEGKQE 1461
+V+L +G+ E
Sbjct: 2252 SPQVSLGDGQSE 2263
Score = 33.9 bits (76), Expect = 1.6
Identities = 51/202 (25%), Positives = 77/202 (38%), Gaps = 19/202 (9%)
Query: 1268 PSSLTVPAIVVDEEDPGLASEGASEG-EGEVSPEGPGLLG--ASQESSMA-GRLGEAGGQ 1323
P S V A E + EG ++ EG+ PE G+ A +E+ A G + EA G+
Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE 2077
Query: 1324 AAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDG--- 1380
A P S + AQE E + E + A + A G + + +G
Sbjct: 2078 AHP---ESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEA 2134
Query: 1381 -EATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGD 1439
EA + ES V + P S G +E Q + +E P AE E
Sbjct: 2135 PEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ-PELEGVEAPEAEGE----- 2188
Query: 1440 LGPSPKAGGLDTEVALDEGKQE 1461
P++ G++ A E + E
Sbjct: 2189 --AQPESEGIEAPEAEGEAQPE 2208
Score = 32.3 bits (72), Expect = 4.5
Identities = 44/162 (27%), Positives = 67/162 (41%), Gaps = 26/162 (16%)
Query: 1281 EDPGLASEGAS----EGEGEVSPEGPGLLGASQESSMAGRLGEA----GG--QAAPGQGP 1330
EDPGL +GA E G ++P GAS +SS + E GG Q PG+
Sbjct: 501 EDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKA- 559
Query: 1331 SAESIAQEPSQ--EEKFPGEALTGLPA----------ATPEELALGARRKRFLPKVRAAG 1378
AE+ QE S+ + P +L+ L + T + R+ + + +
Sbjct: 560 RAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSW 619
Query: 1379 D--GEATTPEERESPTVSPRGPR-KSLVPGSPGTPGRERRSP 1417
D G ++TP S R R ++ SP +PG R +P
Sbjct: 620 DSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAP 661
>gi|16950625 myosin light chain kinase isoform 8 [Homo sapiens]
Length = 154
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/130 (31%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L F +A+ +P F T++ V E S RF C + GYP
Sbjct: 17 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 76
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 77 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 134
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 135 AELIVETMEE 144
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/130 (31%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L F +A+ +P F T++ V E S RF C + GYP
Sbjct: 1726 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1785
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 1786 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 1843
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 1844 AELIVETMEE 1853
Score = 68.6 bits (166), Expect = 6e-11
Identities = 36/110 (32%), Positives = 59/110 (53%), Gaps = 2/110 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P FE+ +S+ V E+ V+F C V+G P+PEV W+ + T + R G E+ H
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEG--SIEVYEDAGSHY 471
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
L L + R D+ Y +A N++G +SCS L+V + ++ + + LK
Sbjct: 472 LCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLK 521
Score = 53.1 bits (126), Expect = 2e-06
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
SS +S + +A ++ T P+F L V + S V T V+G P PEV W + E+
Sbjct: 605 SSRKSEYLLPVAP-SKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI 663
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKI 379
+ +G +H+L + ED Y A NS G V VL V +
Sbjct: 664 QE---SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV--QEPHDG 718
Query: 380 HQRWFAKLKRKAAAKL 395
Q WF R A L
Sbjct: 719 TQPWFISKPRSVTASL 734
Score = 50.8 bits (120), Expect = 1e-05
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F T L V E RF+C +TG P+P+VTW K + L + ++ +
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSA---RVSVSEKNG 214
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L+++ ++D +Y N G S S L +
Sbjct: 215 MQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 43.5 bits (101), Expect = 0.002
Identities = 39/149 (26%), Positives = 58/149 (38%), Gaps = 11/149 (7%)
Query: 228 DGPVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTF-CSIIAQLTE----ETQPLFE 282
+G + + A YL ++ T S S+ + CS Q+ E P F
Sbjct: 458 EGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFS 517
Query: 283 TTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLY 342
+ LK +V E D C V G P P +TW + + +Y T + L +
Sbjct: 518 SVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI-QYA-----RSTCEAGVAELHIQ 571
Query: 343 RCREEDAAIYQASAQNSKGIVSCSGVLEV 371
ED Y A+N+ G VSCS + V
Sbjct: 572 DALPEDHGTYTCLAENALGQVSCSAWVTV 600
Score = 39.3 bits (90), Expect = 0.037
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
TQP F + +S + S V +C + G P P V W +D L + G +E+ +
Sbjct: 719 TQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG--HFEVLQNEDV 776
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSC 365
TL L + + A Y+ +N G SC
Sbjct: 777 FTLVLKKVQPWHAGQYEILLKNRVGECSC 805
Score = 37.4 bits (85), Expect = 0.14
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD---TELDRY---CGLPKYEITH 332
P F ++ + E + +F V GYPEP+VTW+++ T R+ CG+
Sbjct: 33 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGI------- 85
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKG 361
+L ++ EED Y A N G
Sbjct: 86 -RGTFSLVIHAVHEEDRGKYTCEATNGSG 113
Score = 35.0 bits (79), Expect = 0.70
Identities = 48/219 (21%), Positives = 81/219 (36%), Gaps = 26/219 (11%)
Query: 1376 AAGDGEATTPEERESP----TVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASM--LEVP 1429
AA ++P+ SP P+ PR+S + +P ++P + +S L+
Sbjct: 291 AAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAA 350
Query: 1430 RAEEELAAGDLG-----------PSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQV 1478
R + E A LG P+P G Q+ ++K + ++ +
Sbjct: 351 RVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRD 410
Query: 1479 IRKIRVEQFPDA-----SGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAG---DEGP 1530
+ E P + + ++K C+ I V W + PV S D G
Sbjct: 411 SAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEV-AWFLEGTPVRRQEGSIEVYEDAGS 469
Query: 1531 AALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLS 1569
L +++A D G Y CT N G S + L E L+
Sbjct: 470 HYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLA 508
Score = 33.5 bits (75), Expect = 2.0
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 5/94 (5%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
++ T P F+ L+ V+E + C V+ P + W + L K+ I Q
Sbjct: 1093 SQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT----TKFIILSQ 1148
Query: 334 -GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
G+ ++ + + ED +Y+ A+N G CS
Sbjct: 1149 EGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182
Score = 32.7 bits (73), Expect = 3.5
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 1509 LTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAS 1558
+TW + +P+ + RS + G A L I A P D G Y C N G S
Sbjct: 545 ITWLLNGQPI-QYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVS 593
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/130 (31%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L F +A+ +P F T++ V E S RF C + GYP
Sbjct: 1777 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1836
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 1837 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 1894
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 1895 AELIVETMEE 1904
Score = 68.6 bits (166), Expect = 6e-11
Identities = 36/110 (32%), Positives = 59/110 (53%), Gaps = 2/110 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P FE+ +S+ V E+ V+F C V+G P+PEV W+ + T + R G E+ H
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEG--SIEVYEDAGSHY 471
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
L L + R D+ Y +A N++G +SCS L+V + ++ + + LK
Sbjct: 472 LCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLK 521
Score = 53.1 bits (126), Expect = 2e-06
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
SS +S + +A ++ T P+F L V + S V T V+G P PEV W + E+
Sbjct: 605 SSRKSEYLLPVAP-SKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI 663
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKI 379
+ +G +H+L + ED Y A NS G V VL V +
Sbjct: 664 QE---SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV--QEPHDG 718
Query: 380 HQRWFAKLKRKAAAKL 395
Q WF R A L
Sbjct: 719 TQPWFISKPRSVTASL 734
Score = 50.8 bits (120), Expect = 1e-05
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F T L V E RF+C +TG P+P+VTW K + L + ++ +
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSA---RVSVSEKNG 214
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L+++ ++D +Y N G S S L +
Sbjct: 215 MQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 43.5 bits (101), Expect = 0.002
Identities = 39/149 (26%), Positives = 58/149 (38%), Gaps = 11/149 (7%)
Query: 228 DGPVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTF-CSIIAQLTE----ETQPLFE 282
+G + + A YL ++ T S S+ + CS Q+ E P F
Sbjct: 458 EGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFS 517
Query: 283 TTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLY 342
+ LK +V E D C V G P P +TW + + +Y T + L +
Sbjct: 518 SVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI-QYA-----RSTCEAGVAELHIQ 571
Query: 343 RCREEDAAIYQASAQNSKGIVSCSGVLEV 371
ED Y A+N+ G VSCS + V
Sbjct: 572 DALPEDHGTYTCLAENALGQVSCSAWVTV 600
Score = 39.3 bits (90), Expect = 0.037
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
TQP F + +S + S V +C + G P P V W +D L + G +E+ +
Sbjct: 719 TQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG--HFEVLQNEDV 776
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSC 365
TL L + + A Y+ +N G SC
Sbjct: 777 FTLVLKKVQPWHAGQYEILLKNRVGECSC 805
Score = 37.4 bits (85), Expect = 0.14
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD---TELDRY---CGLPKYEITH 332
P F ++ + E + +F V GYPEP+VTW+++ T R+ CG+
Sbjct: 33 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGI------- 85
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKG 361
+L ++ EED Y A N G
Sbjct: 86 -RGTFSLVIHAVHEEDRGKYTCEATNGSG 113
Score = 35.0 bits (79), Expect = 0.70
Identities = 48/219 (21%), Positives = 81/219 (36%), Gaps = 26/219 (11%)
Query: 1376 AAGDGEATTPEERESP----TVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASM--LEVP 1429
AA ++P+ SP P+ PR+S + +P ++P + +S L+
Sbjct: 291 AAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAA 350
Query: 1430 RAEEELAAGDLG-----------PSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQV 1478
R + E A LG P+P G Q+ ++K + ++ +
Sbjct: 351 RVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRD 410
Query: 1479 IRKIRVEQFPDA-----SGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAG---DEGP 1530
+ E P + + ++K C+ I V W + PV S D G
Sbjct: 411 SAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEV-AWFLEGTPVRRQEGSIEVYEDAGS 469
Query: 1531 AALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLS 1569
L +++A D G Y CT N G S + L E L+
Sbjct: 470 HYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLA 508
Score = 33.5 bits (75), Expect = 2.0
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 5/94 (5%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
++ T P F+ L+ V+E + C V+ P + W + L K+ I Q
Sbjct: 1093 SQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT----TKFIILSQ 1148
Query: 334 -GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
G+ ++ + + ED +Y+ A+N G CS
Sbjct: 1149 EGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182
Score = 32.7 bits (73), Expect = 3.5
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 1509 LTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAS 1558
+TW + +P+ + RS + G A L I A P D G Y C N G S
Sbjct: 545 ITWLLNGQPI-QYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVS 593
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/130 (31%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L F +A+ +P F T++ V E S RF C + GYP
Sbjct: 1657 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1716
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 1717 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 1774
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 1775 AELIVETMEE 1784
Score = 53.1 bits (126), Expect = 2e-06
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
SS +S + +A ++ T P+F L V + S V T V+G P PEV W + E+
Sbjct: 536 SSRKSEYLLPVAP-SKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI 594
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKI 379
+ +G +H+L + ED Y A NS G V VL V +
Sbjct: 595 QE---SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV--QEPHDG 649
Query: 380 HQRWFAKLKRKAAAKL 395
Q WF R A L
Sbjct: 650 TQPWFISKPRSVTASL 665
Score = 50.8 bits (120), Expect = 1e-05
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F T L V E RF+C +TG P+P+VTW K + L + ++ +
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSA---RVSVSEKNG 214
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L+++ ++D +Y N G S S L +
Sbjct: 215 MQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 41.6 bits (96), Expect = 0.007
Identities = 29/96 (30%), Positives = 40/96 (41%), Gaps = 6/96 (6%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F + LK +V E D C V G P P +TW + + +Y T +
Sbjct: 442 EVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI-QYA-----RSTCEAG 495
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED Y A+N+ G VSCS + V
Sbjct: 496 VAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 531
Score = 39.3 bits (90), Expect = 0.037
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
TQP F + +S + S V +C + G P P V W +D L + G +E+ +
Sbjct: 650 TQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG--HFEVLQNEDV 707
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSC 365
TL L + + A Y+ +N G SC
Sbjct: 708 FTLVLKKVQPWHAGQYEILLKNRVGECSC 736
Score = 37.4 bits (85), Expect = 0.14
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD---TELDRY---CGLPKYEITH 332
P F ++ + E + +F V GYPEP+VTW+++ T R+ CG+
Sbjct: 33 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGI------- 85
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKG 361
+L ++ EED Y A N G
Sbjct: 86 -RGTFSLVIHAVHEEDRGKYTCEATNGSG 113
Score = 37.4 bits (85), Expect = 0.14
Identities = 54/212 (25%), Positives = 84/212 (39%), Gaps = 34/212 (16%)
Query: 1373 KVRAAGDGEATTPE----ERESPTVSPRGPRKSLVPGSPGT-----PGRERRSPTQGRKA 1423
K+ + D T P+ ++ S +++ + R P +PG G ER+ P R A
Sbjct: 321 KLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPA 380
Query: 1424 SMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIR 1483
+ P + L + D+ + E D + +KP+ + +K Q + K R
Sbjct: 381 TF---PTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQE--VKENQTV-KFR 434
Query: 1484 VEQF------PDASGSLK----LWCQFFNILSDSV-------LTWAKDQRPVGEVGRSAG 1526
E P S LK + Q F +L SV +TW + +P+ + RS
Sbjct: 435 CEGLAVMEVAPSFSSVLKDCAVIEGQDF-VLQCSVRGTPVPRITWLLNGQPI-QYARSTC 492
Query: 1527 DEGPAALAIVQASPVDCGVYRCTIHNEHGSAS 1558
+ G A L I A P D G Y C N G S
Sbjct: 493 EAGVAELHIQDALPEDHGTYTCLAENALGQVS 524
Score = 33.5 bits (75), Expect = 2.0
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 5/94 (5%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
++ T P F+ L+ V+E + C V+ P + W + L K+ I Q
Sbjct: 1024 SQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT----TKFIILSQ 1079
Query: 334 -GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
G+ ++ + + ED +Y+ A+N G CS
Sbjct: 1080 EGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1113
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/130 (31%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L F +A+ +P F T++ V E S RF C + GYP
Sbjct: 1708 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1767
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 1768 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 1825
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 1826 AELIVETMEE 1835
Score = 53.1 bits (126), Expect = 2e-06
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
SS +S + +A ++ T P+F L V + S V T V+G P PEV W + E+
Sbjct: 536 SSRKSEYLLPVAP-SKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI 594
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKI 379
+ +G +H+L + ED Y A NS G V VL V +
Sbjct: 595 QE---SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV--QEPHDG 649
Query: 380 HQRWFAKLKRKAAAKL 395
Q WF R A L
Sbjct: 650 TQPWFISKPRSVTASL 665
Score = 50.8 bits (120), Expect = 1e-05
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F T L V E RF+C +TG P+P+VTW K + L + ++ +
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSA---RVSVSEKNG 214
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L+++ ++D +Y N G S S L +
Sbjct: 215 MQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 41.6 bits (96), Expect = 0.007
Identities = 29/96 (30%), Positives = 40/96 (41%), Gaps = 6/96 (6%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F + LK +V E D C V G P P +TW + + +Y T +
Sbjct: 442 EVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI-QYA-----RSTCEAG 495
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED Y A+N+ G VSCS + V
Sbjct: 496 VAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV 531
Score = 39.3 bits (90), Expect = 0.037
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
TQP F + +S + S V +C + G P P V W +D L + G +E+ +
Sbjct: 650 TQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG--HFEVLQNEDV 707
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSC 365
TL L + + A Y+ +N G SC
Sbjct: 708 FTLVLKKVQPWHAGQYEILLKNRVGECSC 736
Score = 37.4 bits (85), Expect = 0.14
Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD---TELDRY---CGLPKYEITH 332
P F ++ + E + +F V GYPEP+VTW+++ T R+ CG+
Sbjct: 33 PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGI------- 85
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKG 361
+L ++ EED Y A N G
Sbjct: 86 -RGTFSLVIHAVHEEDRGKYTCEATNGSG 113
Score = 37.4 bits (85), Expect = 0.14
Identities = 54/212 (25%), Positives = 84/212 (39%), Gaps = 34/212 (16%)
Query: 1373 KVRAAGDGEATTPE----ERESPTVSPRGPRKSLVPGSPGT-----PGRERRSPTQGRKA 1423
K+ + D T P+ ++ S +++ + R P +PG G ER+ P R A
Sbjct: 321 KLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPA 380
Query: 1424 SMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIR 1483
+ P + L + D+ + E D + +KP+ + +K Q + K R
Sbjct: 381 TF---PTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQE--VKENQTV-KFR 434
Query: 1484 VEQF------PDASGSLK----LWCQFFNILSDSV-------LTWAKDQRPVGEVGRSAG 1526
E P S LK + Q F +L SV +TW + +P+ + RS
Sbjct: 435 CEGLAVMEVAPSFSSVLKDCAVIEGQDF-VLQCSVRGTPVPRITWLLNGQPI-QYARSTC 492
Query: 1527 DEGPAALAIVQASPVDCGVYRCTIHNEHGSAS 1558
+ G A L I A P D G Y C N G S
Sbjct: 493 EAGVAELHIQDALPEDHGTYTCLAENALGQVS 524
Score = 33.5 bits (75), Expect = 2.0
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 5/94 (5%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
++ T P F+ L+ V+E + C V+ P + W + L K+ I Q
Sbjct: 1024 SQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT----TKFIILSQ 1079
Query: 334 -GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
G+ ++ + + ED +Y+ A+N G CS
Sbjct: 1080 EGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1113
>gi|140560917 myomesin 1 isoform b [Homo sapiens]
Length = 1589
Score = 68.2 bits (165), Expect = 7e-11
Identities = 50/169 (29%), Positives = 76/169 (44%), Gaps = 23/169 (13%)
Query: 235 SPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLT-----EETQ----------- 278
S ASR ++S + ++L S S + +L+ EET+
Sbjct: 214 STASRQSVVSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHL 273
Query: 279 ---PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
P F +S +V E +V+ C + G+PEP VTWYK+ ++ + KY I +
Sbjct: 274 LHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYG 333
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV----GTMTEYKIH 380
HTL++ C ED A Y+ASA N KG +S + V G E + H
Sbjct: 334 MHTLEINGCDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFH 382
Score = 34.7 bits (78), Expect = 0.92
Identities = 16/60 (26%), Positives = 29/60 (48%)
Query: 1496 LWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
L C+ NI ++ + W KD+R + + +G L I + S D G+Y + ++ G
Sbjct: 1280 LKCKVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1339
Score = 32.7 bits (73), Expect = 3.5
Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 3/43 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYE 329
++ E + TC V G P PEV+W K++ L D +C L K+E
Sbjct: 1487 TIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNL-KFE 1528
>gi|140560919 myomesin 1 isoform a [Homo sapiens]
Length = 1685
Score = 68.2 bits (165), Expect = 7e-11
Identities = 50/169 (29%), Positives = 76/169 (44%), Gaps = 23/169 (13%)
Query: 235 SPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLT-----EETQ----------- 278
S ASR ++S + ++L S S + +L+ EET+
Sbjct: 214 STASRQSVVSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHL 273
Query: 279 ---PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
P F +S +V E +V+ C + G+PEP VTWYK+ ++ + KY I +
Sbjct: 274 LHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYG 333
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV----GTMTEYKIH 380
HTL++ C ED A Y+ASA N KG +S + V G E + H
Sbjct: 334 MHTLEINGCDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFH 382
Score = 34.7 bits (78), Expect = 0.92
Identities = 16/60 (26%), Positives = 29/60 (48%)
Query: 1496 LWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
L C+ NI ++ + W KD+R + + +G L I + S D G+Y + ++ G
Sbjct: 1376 LKCKVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1435
Score = 32.7 bits (73), Expect = 3.5
Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 3/43 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYE 329
++ E + TC V G P PEV+W K++ L D +C L K+E
Sbjct: 1583 TIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNL-KFE 1624
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 67.4 bits (163), Expect = 1e-10
Identities = 225/1083 (20%), Positives = 362/1083 (33%), Gaps = 202/1083 (18%)
Query: 506 PQRALKEESGAKKKKKDEESKQGLRKPELEKAA-----QSRRSSENCIP----------- 549
P+R K+ S KK + + ESK+ + K+ + R+ S + P
Sbjct: 205 PRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRST 264
Query: 550 SSDEPDSCGT----QGPVGVEQVQTQPRGRA------ARGPGSS-----GTDSTRKPASA 594
S+D S T + T GR+ RG G + GT ST++P+S
Sbjct: 265 SADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSS- 323
Query: 595 VGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPL 654
P+ A K P P ++ KD + A RP P+ S G P PL
Sbjct: 324 ---PETATKQPS-SPYED-----KDKDKKEKSATRP--SPSPERSST---GPEPPAPTPL 369
Query: 655 RARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQS 714
A G G+P P T P +++ PP + T D P S + P+ +
Sbjct: 370 LAERHG--GSP-------QPLATTPLSQEPVNPPS-EASPTRDRSPPKSPEKLPQSSSSE 419
Query: 715 LGKAPPQ---------ASVQVPTP-PARRRHGTRDSTLQGQAGHRTPGEVLECQT---TT 761
PQ +S + P P PA H R+ + + +R+ G ++ T
Sbjct: 420 SSPPSPQPTKVSRHASSSPESPKPAPAPGSH--REISSSPTSKNRSHGRAKRDKSHSHTP 477
Query: 762 APTMSASSSSDVASIGVSTS------GSQGIIEPM---DMETQEDGRTSANQRTGSKKNV 812
+ M S S A G S S G P Q GR+ + QR G ++
Sbjct: 478 SRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSP 537
Query: 813 QADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQ 872
Q G + R +++A+R R+ ++ G S+ P ++ + R+ ++
Sbjct: 538 QRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSR 597
Query: 873 LETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVAT 932
T + R+ ++ T RR + ++ +S +P G+S
Sbjct: 598 TPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVR----RRSRSRSPARRSGRSRSRTPA 653
Query: 933 SLG-PPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQT 991
G SRTP + R P G + P RS R+ ++
Sbjct: 654 RRGRSRSRTPARRGRSRSRTPAR-------RSGRSRSRTPARRGRSRSRTPRRGRSRSRS 706
Query: 992 VLGPLSGNLMLPAQPPHEGSVEQVGGE----RCRGPQSSGPVEAKQEDS-----PFQCPK 1042
++ + P + GS + + + R +S P K S P+
Sbjct: 707 LVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPR 766
Query: 1043 EERPGGVPCMD--QGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTA--- 1097
+ + G P + P S G ++ PKA + P S++
Sbjct: 767 SKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSG---SSQPKAKSRTPPRRSRSSSSPPP 823
Query: 1098 ---TFLPSEDQVLMSSAPTLHLGLGTP------TQSHPPETMATSSEGACAQV---PDVE 1145
+ PS Q SS+P + GTP T E T +C + P+++
Sbjct: 824 KQKSKTPSR-QSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELK 882
Query: 1146 GRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEV 1205
RTP SC +K+ S + + ++ + S++ +P+
Sbjct: 883 SRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVT 942
Query: 1206 AGLSPRTSRRI--LERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGS 1263
+ +PR SR + VE+ L + + + SP T + + +
Sbjct: 943 SRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ 1002
Query: 1264 WGPGPS-----------------------SLTVPAIVVDEEDPGLASEGAS----EGEGE 1296
PGPS SL++ A V PG + G S +G+ +
Sbjct: 1003 TPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQ 1062
Query: 1297 VSP----------------EGPGLLGASQESSMAGR-------------------LGE-- 1319
SP E P L SQ S GR GE
Sbjct: 1063 TSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFS 1122
Query: 1320 AGGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGD 1379
A G P + S +L G E ++ K LP D
Sbjct: 1123 ASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAE----SKEKMALPPQE---D 1175
Query: 1380 GEATTPEERE--SPTVSPRGPRKSLV-PGSPGTPGRER----RSPTQGRKASMLEVPRAE 1432
A+ P +++ SP P SLV + TP RER SP + S L +
Sbjct: 1176 ATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQD 1235
Query: 1433 EEL 1435
EEL
Sbjct: 1236 EEL 1238
Score = 67.4 bits (163), Expect = 1e-10
Identities = 253/1114 (22%), Positives = 382/1114 (34%), Gaps = 231/1114 (20%)
Query: 506 PQRALKEESGAKKKKKDEESKQGLRK---PELEKAA-QSRRSSENCIPSSDEPD------ 555
PQR + S +++K K S++ R PE++K+ SRRS P S
Sbjct: 718 PQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRR 777
Query: 556 SCGTQGPVGVEQVQTQPR---GRAARGPGSSGTDSTRKPASAVGTPDKAQKAP------- 605
S P ++ QT PR +++ S T R +S+ P + K P
Sbjct: 778 SLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSS 837
Query: 606 ---------GPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQT-LSVRAPGE-SPKGKAPL 654
G P Q S + T R E P L R P S G +P
Sbjct: 838 SSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPP 897
Query: 655 RARSEGVPGAPGQPTHSLTPQPT-----RPFNRKRFAPPKPK-GEATTDSKPISSLSQAP 708
R +S P P+ S +PQP P R P T+ + P S S +P
Sbjct: 898 RVKSSTPPRQ--SPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSP 955
Query: 709 ECGAQSL--------GKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTT 760
+S G + P V+ TPP Q +G +P ++ QT
Sbjct: 956 CSNVESRLLPRYSHSGSSSPDTKVKPETPPR-----------QSHSGSISPYPKVKAQTP 1004
Query: 761 TAPTMSASSS-------------------SDVASIGVSTSGSQGIIEPMDMETQEDGRTS 801
P++S S S S A + ST + ++ + +TS
Sbjct: 1005 PGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTS 1064
Query: 802 ANQRTGSK---------KNVQADGKIQVD---GRTRGDG--TQTAQRT--RADR-----K 840
+ R+ + ++ K Q GR+R T+ A R+ R DR
Sbjct: 1065 PDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSAS 1124
Query: 841 TQVDAG-TQESKRPQSDRSAQKGMMTQGR-AETQLETTQAGEKI----QEDRKA----QA 890
+ +G + E R QSD S+ + + +++LET ++ EK+ QED A Q
Sbjct: 1125 PMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQK 1184
Query: 891 DKGTQ---EDRRMQG-------------EKGMQGEKGTQSEGSA-PTAMEGQSEQEVATS 933
DK + +DR G T+ + SA PT+ + + EV
Sbjct: 1185 DKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEK 1244
Query: 934 LGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSE-----EAVVTASR-- 986
P+ L + ++ F +PE P L +S+ EAV S
Sbjct: 1245 SEEPAGQI-LSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMAS 1303
Query: 987 ---------NHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQS------SGPVEA 1031
H++ PL N P + +G E G S +GP
Sbjct: 1304 SWGGPHFSPEHKELSNSPLRENSF--GSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLN 1361
Query: 1032 KQEDSPFQCPKEE--RPGGVPC--MDQGGCPLAGLSQEV----PTMPSLPGTGLTASPKA 1083
+ E P KE+ R G + AG+S P + ++P T + ++
Sbjct: 1362 QLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRT--PSRERS 1419
Query: 1084 GPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQ-----SHP-----PETMATS 1133
S+P + G T PS + S+P L G GTP++ S P P T +
Sbjct: 1420 SSASSPEMKDGLPRT--PSR-RSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRG 1476
Query: 1134 -SEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGG 1192
SE + P +TP PRS P + L N K + + +G ES V T
Sbjct: 1477 RSECDSSPEPKALPQTPRPRSRSPSSPE-LNN------KCLTPQRERSGSESSVDQKTVA 1529
Query: 1193 LVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQA 1252
P + + L + S ER E++ S + +P R +G
Sbjct: 1530 RTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDS-KAKTRTPLRQRSRSGSSPEVDSK 1588
Query: 1253 GRQALAAARGSWGP--------------GPSSLTVPAIVVDEEDPGLASEGASEGEGEVS 1298
R + +R P G S P P + G+S S
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS 1648
Query: 1299 PEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATP 1358
PEG +S E R G +++P EP + + P + +
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSP-----------EPKTKSRTPPRRRSSRSSPEL 1697
Query: 1359 EELALGARRKRFL---PKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRERR 1415
A +RR R P+ R+ T P R SP+VS SP P + R
Sbjct: 1698 TRKARLSRRSRSASSSPETRS-----RTPPRHRRSPSVS-----------SP-EPAEKSR 1740
Query: 1416 SPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGL 1449
S + R AS PR + G PSPK GL
Sbjct: 1741 SSRRRRSASS---PRTKTTSRRG-RSPSPKPRGL 1770
Score = 48.1 bits (113), Expect = 8e-05
Identities = 211/1040 (20%), Positives = 350/1040 (33%), Gaps = 97/1040 (9%)
Query: 424 QRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAA 483
+R R S ++ GPS PEG + E E S S +S E T
Sbjct: 1634 RRSRSGSSSKGRGPS-----PEGSSST---ESSPEHPPKSRTARRGSRSSPEPKTKSRTP 1685
Query: 484 PENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRS 543
P LT + E+ ++ + S EK+ SRR
Sbjct: 1686 PRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRR 1745
Query: 544 SENCIPSSDEPDSCG---TQGPVGVEQVQTQPRGRAARGP------GSSGTDSTRKPASA 594
P + G + P G+++ +++ R R GSS + S R+ S
Sbjct: 1746 RSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSR 1805
Query: 595 VGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGES---PKGK 651
+ ++ G G Y S P +E +T S R G S P +
Sbjct: 1806 SRSRVTRRRRGGSG-----YHSRS-----------PARQESSRTSSRRRRGRSRTPPTSR 1849
Query: 652 APLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPIS---SLSQAP 708
R+RS P AP + + S T +R R P + + + + P+S S S+
Sbjct: 1850 K--RSRSRTSP-APWKRSRSRASPATHRRSRSR-TPLISRRRSRSRTSPVSRRRSRSRTS 1905
Query: 709 ECGAQSLGKAPP--QASVQVPTPPA-RRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTM 765
+S +A P + + TPP RRR +R T + ++ RTP + P +
Sbjct: 1906 VTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPV 1965
Query: 766 SASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTR 825
+ S S ++ S+ P+ RTS R S+ V R
Sbjct: 1966 TRRRSRSRTS-PITRRRSRSRTSPVTRRRSRS-RTSPVTRRRSRSRTSP-----VTRRRS 2018
Query: 826 GDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQED 885
T A R R+ +T + + R + T A + T++ I
Sbjct: 2019 RSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAI--- 2075
Query: 886 RKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPK--- 942
R+ A + + R + G+++ A + + S P R
Sbjct: 2076 RRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGM 2135
Query: 943 LPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLG-PLSGNLM 1001
L P R P+++ +Q GS +P + V NH Q+ + L+ +
Sbjct: 2136 LEPLGSSRTPMSV---LQQAGGSMMDGPGPRIPDHQRTSVP--ENHAQSRIALALTAISL 2190
Query: 1002 LPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAG 1061
A+PP S G R Q PV S P +P LA
Sbjct: 2191 GTARPPPSMSA---AGLAARMSQVPAPVPLM---SLRTAPAANLASRIPAASAAAMNLA- 2243
Query: 1062 LSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHL-GLGT 1120
S P +P+ + +P A S + A + +AP ++L G T
Sbjct: 2244 -SARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGART 2302
Query: 1121 PTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGA 1180
P + + A P P S + L+ + + ++ + T+ A
Sbjct: 2303 PAALAALSLTGSGTPPTAANYPSSSRTPQAPASAN--LVGPRSAHATAPVNIAGSRTAAA 2360
Query: 1181 -GGESQVGAATGGLVPSATLT-PTVEVAG---LSPRTSRRILERVENNHLVQSAQTLLLS 1235
S A + A LT P V ++ +S RTS +L+R + + S
Sbjct: 2361 LAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQ---S 2417
Query: 1236 PCTSRRLTGLLDREVQAGRQALA--AARGSWGPGPSSLTVPA-IVVDEEDPGLASEGASE 1292
TS R R QA Q+L A P PS+ + + ++ + P S+ S
Sbjct: 2418 RMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSS 2477
Query: 1293 GEGEVSPEGPG----LLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFPGE 1348
G + G +L +GE Q PSA + A +P++E +
Sbjct: 2478 GAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTG-AQQPSALA-ALQPAKERRSSSS 2535
Query: 1349 ALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEER----ESPTVSPRGPRKSLVP 1404
+ + +++ + + + G PE SPT +P+ + P
Sbjct: 2536 SSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRP 2595
Query: 1405 GSPGTPGRERRSPTQGRKAS 1424
P R+RRS + +S
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSS 2615
Score = 46.6 bits (109), Expect = 2e-04
Identities = 96/468 (20%), Positives = 159/468 (33%), Gaps = 59/468 (12%)
Query: 505 GPQRALKEESGAKKKKKDEESKQGL----RKPELEKAAQSRRSSENCIPSSDEPDSCGTQ 560
G L++ SG + S G+ R P ++ +P + P S
Sbjct: 1442 GSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPS 1501
Query: 561 GPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDM 620
P + T R R SG++S+ + TP + G QE+
Sbjct: 1502 SPELNNKCLTPQRER-------SGSESSVDQKTVARTP--LGQRSRSGSSQEL------- 1545
Query: 621 YLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPF 680
V+P ++ S +P K + PLR RS L+P+ +R
Sbjct: 1546 ------DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSG 1599
Query: 681 NR---KRFAPPKPKGEATTDSKP------ISSLSQAPECGAQSLGKAP-PQASVQVPT-- 728
+ K P+ ++ +DS P +L + G+ S G+ P P+ S +
Sbjct: 1600 SSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSP 1659
Query: 729 --PPARR--RHGTRDS--------TLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVAS- 775
PP R R G+R S T + R+ E+ + + SASSS + S
Sbjct: 1660 EHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSR 1719
Query: 776 IGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRT 835
S + P E E R+S +R+ S + + GR+ + QR+
Sbjct: 1720 TPPRHRRSPSVSSP---EPAEKSRSSRRRRSASSPRTKTTSR---RGRSPSPKPRGLQRS 1773
Query: 836 RADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQ 895
R+ + + T+ R S +S + + G A+ +
Sbjct: 1774 RSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRT 1833
Query: 896 EDRRMQGEKGM--QGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTP 941
RR +G K ++S S +S AT SRTP
Sbjct: 1834 SSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTP 1881
Score = 39.7 bits (91), Expect = 0.028
Identities = 48/192 (25%), Positives = 70/192 (36%), Gaps = 21/192 (10%)
Query: 35 LPGLPRS---SPSWPAVDLAPLAPARPRGPLICHTGHEQAGREPGPGSSTKGPVLHDQDT 91
LP PR SPS P ++ L P R R + R P G ++ + D
Sbjct: 1489 LPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP-LGQRSRSGSSQELDV 1547
Query: 92 RCAFLPR--------PPGPLQTRRYCRHQGRQGSGLGA------GPGAGTWAPAPPGVSK 137
+ + P+ P +TR R + R GS P +P K
Sbjct: 1548 KPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDK 1607
Query: 138 PRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAV 197
PR RA+ G A PA R+ R+G+++ GRGP + E++ P
Sbjct: 1608 PRAAPRAQSGSDSSPEPKA--PAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPE-HPPK 1664
Query: 198 GEGGAMGSRRAP 209
GSR +P
Sbjct: 1665 SRTARRGSRSSP 1676
Score = 37.7 bits (86), Expect = 0.11
Identities = 77/380 (20%), Positives = 128/380 (33%), Gaps = 47/380 (12%)
Query: 409 PGEVDTLRKLSPDRFQRKRRLSGAQAPGPS-----VPTR--------EPEGGTLAAW-QE 454
P +D R +P + R++ +AP PS P++ +P +A+ +
Sbjct: 2399 PPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQ 2458
Query: 455 GETETAQHSGLGLINSFASGEV-TTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEE 513
AQ + + S +SG V TT A NG D E ++
Sbjct: 2459 SRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQP 2518
Query: 514 S--GAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQ 571
S A + K+ S ++ S SS + S DS G+ PV Q
Sbjct: 2519 SALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPV-------Q 2571
Query: 572 PRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPL 631
P R P T P AV + + P P P + K ++ +
Sbjct: 2572 PEVALKRVP-----SPTPAPKEAV----REGRPPEPTPAKR-----KRRSSSSSSSSSSS 2617
Query: 632 GEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPK 691
+ S + S + + S +P +P P+P P PP +
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKK-----PPPGE 2672
Query: 692 GEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAG-HRT 750
+ + KPI SL + + + P P+P ++ + + +GQ G R+
Sbjct: 2673 RRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQ---PSPRDQQSSSSERGSRRGQRGDSRS 2729
Query: 751 PGEVLECQTTTAPTMSASSS 770
P +T + M SS
Sbjct: 2730 PSHKRRRETPSPRPMRHRSS 2749
Score = 35.4 bits (80), Expect = 0.54
Identities = 57/269 (21%), Positives = 91/269 (33%), Gaps = 28/269 (10%)
Query: 435 PGPSVP---TREPEGGT-------LAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAP 484
P P VP EP T LAA Q + + S +S +S +++ ++
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556
Query: 485 ENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSS 544
+ G ++ + P+ ALK K E ++G R PE A + RRSS
Sbjct: 2557 GSSSSDSEG------SSLPVQPEVALKRVPSPTPAPK-EAVREG-RPPEPTPAKRKRRSS 2608
Query: 545 ENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKA 604
+ SS S + + ++ SS + S KP + K
Sbjct: 2609 SSS-SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKK 2667
Query: 605 PGPG-----PGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSE 659
P PG ++ SL+D + + P+ P +S + R
Sbjct: 2668 PPPGERRSRSPRKPIDSLRD---SRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQR 2724
Query: 660 GVPGAPGQPTHSLTPQPTRPFNRKRFAPP 688
G +P TP P RP + P
Sbjct: 2725 GDSRSPSHKRRRETPSP-RPMRHRSSRSP 2752
Score = 32.7 bits (73), Expect = 3.5
Identities = 86/455 (18%), Positives = 159/455 (34%), Gaps = 49/455 (10%)
Query: 507 QRALKEESGAKKKKKDEESKQGLRK----------PELEKAAQSRRSSENCIPSSDEPDS 556
QR L G + ++ D + ++ LR+ P++ + RR C+ + +
Sbjct: 20 QRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEE 79
Query: 557 CGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVG-TPDKAQKAPGPGPGQEVYF 615
G + E+V T + G + T AV T A+ F
Sbjct: 80 QGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAF 139
Query: 616 SLKDMYLENT---------QAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPG 666
+ D Y++ + +A +P E P+ S+ S + P + + + G
Sbjct: 140 GISDSYVDGSSFDPQRRAREAKQP-APEPPKPYSLVRESSSSRSPTPKQKKKKKKKDR-G 197
Query: 667 QPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQV 726
+ + S +P+ R + K K K + ++SK S P+ +S K ++
Sbjct: 198 RRSESSSPRRERKKSSK-----KKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTT 252
Query: 727 PTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGI 786
P P +RR H R ++ + T + + +A+ + A G S S + G
Sbjct: 253 PAPKSRRAH--RSTSADSASSSDT--------SRSRSRSAAAKTHTTALAGRSPSPASGR 302
Query: 787 IEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAG 846
D E G TS QR S + + + + ++A TR + +
Sbjct: 303 RGEGDAPFSEPGTTS-TQRPSSPETATKQPSSPYEDKDKDKKEKSA--TRPSPSPERSST 359
Query: 847 TQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGM 906
E P + + G Q A T L QE ++ D R +
Sbjct: 360 GPEPPAPTPLLAERHGGSPQPLATTPLS--------QEPVNPPSEASPTRD-RSPPKSPE 410
Query: 907 QGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTP 941
+ + + SE S P+ + + ++S P P
Sbjct: 411 KLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAP 445
Score = 31.6 bits (70), Expect = 7.7
Identities = 59/285 (20%), Positives = 95/285 (33%), Gaps = 43/285 (15%)
Query: 508 RALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDS-CGTQGPVGVE 566
R E + + + + Q L P AQ + S +PS+ S C V
Sbjct: 2418 RMTSERAPSPSSRMGQAPSQSLLPP-----AQDQPRSP--VPSAFSDQSRCLIAQTTPVA 2470
Query: 567 QVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQ 626
Q+ G A S+G + A G P P G + +L
Sbjct: 2471 GSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALA-------- 2522
Query: 627 AVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFA 686
A++P E + S + S + + S + SL QP R
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582
Query: 687 PPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQA 746
P PK EA + +P PE PTP R+R + S+ +
Sbjct: 2583 TPAPK-EAVREGRP-------PE-----------------PTPAKRKRRSSSSSSSSSSS 2617
Query: 747 GHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTS--GSQGIIEP 789
+ ++++ + S+SSSS +S S + G Q + +P
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKP 2662
>gi|16950623 myosin light chain kinase isoform 7 [Homo sapiens]
Length = 153
Score = 65.9 bits (159), Expect = 4e-10
Identities = 41/130 (31%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 247 PETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYP 306
P + L++ +L ++ F +A+ +P F T++ V E S RF C + GYP
Sbjct: 17 PTSPLNAEKLESEDVSQA-FLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 75
Query: 307 EPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+PEV W+KDD + R + + GN + C ++DA Y A NS G +C+
Sbjct: 76 DPEVVWFKDDQSI-RESRHFQIDYDEDGNCSLIISDVCGDDDAK-YTCKAVNSLGEATCT 133
Query: 367 GVLEVGTMTE 376
L V TM E
Sbjct: 134 AELIVETMEE 143
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 65.1 bits (157), Expect = 6e-10
Identities = 254/1081 (23%), Positives = 354/1081 (32%), Gaps = 190/1081 (17%)
Query: 485 ENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSS 544
E GE G G D +GP A G K +K D G P Q R
Sbjct: 1532 EKGEPGRPG------DPAVVGPAVA-----GPKGEKGDV----GPAGPRGATGVQGERGP 1576
Query: 545 ENCIPSSDE--PDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVG------ 596
+ D G +GP+G+ + P G + PG G P VG
Sbjct: 1577 PGLVLPGDPGPKGDPGDRGPIGLTG-RAGPPGDSGP-PGEKGDPGRPGPPGPVGPRGRDG 1634
Query: 597 -TPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVR-PLGEEGPQTLSVRAPGESPKGKAPL 654
+K + P PG + + L VR P+GE+G Q PGE + +P
Sbjct: 1635 EVGEKGDEGPPGDPG--LPGKAGERGLRGAPGVRGPVGEKGDQG----DPGEDGRNGSPG 1688
Query: 655 RARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAP-ECGAQ 713
+ +G G PG P T P R++ P E K L AP E G +
Sbjct: 1689 SSGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDPGLPGAPGERGIE 1748
Query: 714 SLGKAP-PQASVQVPTPPARRRHGTRDST-LQGQAG-HRTPGEVLECQTTTAPTMSASSS 770
P PQ V P + G R L G++G PG + P +A +
Sbjct: 1749 GFRGPPGPQGDPGVRGPAGEK--GDRGPPGLDGRSGLDGKPGAA----GPSGPNGAAGKA 1802
Query: 771 SDVASIGV-STSGSQGIIEP-----MDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRT 824
D G+ G QG+ P + + EDG+ N + G + DG+ G +
Sbjct: 1803 GDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEKGDS 1862
Query: 825 RGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQE 884
G + + +R G PQ + G+ G +
Sbjct: 1863 GASGREGRDGPKGER------GAPGILGPQGPPGLPGPVGPPGQG---FPGVPGGTGPKG 1913
Query: 885 DRKAQADKGTQEDRRMQGEKGMQGEKGT--------------------------QSEGS- 917
DR KG Q + GE+G++GE G+ +S GS
Sbjct: 1914 DRGETGSKGEQG---LPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSF 1970
Query: 918 APTAMEGQSEQEVATSLGPPSRTPKL-----------PPTAGPRAPLNIECFVQTPEG-- 964
P + + + GPP + + GP+ P + + P G
Sbjct: 1971 LPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPPGLALGERGPPGPS 2030
Query: 965 --SCFPKKPGC--LPRSEEAVVTASRNHEQTVLGP--------------LSGNLMLPAQP 1006
+ P KPG LP V A R E+ G L G P P
Sbjct: 2031 GLAGEPGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPP 2090
Query: 1007 PHEGSVEQVG----GERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCM--DQGGCPLA 1060
+ SV++ G GE +GP + + + Q PK +R GVP + D+G
Sbjct: 2091 GPKVSVDEPGPGLSGE--QGPPGLKGAKGEPGSNGDQGPKGDR--GVPGIKGDRGEPGPR 2146
Query: 1061 GLSQEVPTMPSLPGTGLTASPKA-----GPCSTPTSQHGSTATFLPSEDQVLMSSAPTLH 1115
G P LPG A P+ GP P G P + + P
Sbjct: 2147 GQDGN----PGLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAGPQGP 2202
Query: 1116 LGL-GTPTQSHPPETMATSSEGACAQVPDVEGRT--PGPRSCDPGLIDSLKNYLLLLLKL 1172
GL G P ++ PP T GA +P G + GP+ PGL + K
Sbjct: 2203 SGLKGEPGETGPPGRGLTGPTGAVG-LPGPPGPSGLVGPQG-SPGLPGQVGE----TGKP 2256
Query: 1173 SSTETSGAGGESQVGAATG-----GL--------VPSATLTPTVEVAGLSPRTSRRILER 1219
+ GA G+ + G GL P T P V GL +
Sbjct: 2257 GAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGAPG 2316
Query: 1220 VENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWG----PGPSSLTVPA 1275
LV R L G + +AGR G G PGP
Sbjct: 2317 GLAGDLVGEP-----GAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKGAPGPKGF---- 2367
Query: 1276 IVVDEEDPGLASEGASEGEGEVSPEG----PGLLGASQESSMAGRLGEAGGQAAPGQGPS 1331
+ DPG+ G+ G +G PGL GA G+ G G P GPS
Sbjct: 2368 ----KGDPGVGVPGSPGPPGPPGVKGDLGLPGLPGAPGVVGFPGQTGPRGEMGQP--GPS 2421
Query: 1332 AESIAQEPSQEEKFPGE-ALTGLPAATPEELALGARRKRFLPKVRAAGD-GEATTPEER- 1388
E P E PG G P + A G + + P V G GE P R
Sbjct: 2422 GERGLAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIRG 2481
Query: 1389 ESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGG 1448
E GPR + G PG+ G G ++ L+ + + + G GP G
Sbjct: 2482 EDGRPGQEGPRG--LTGPPGSRGERGEKGDVG--SAGLKGDKGDSAVILGPPGPRGAKGD 2537
Query: 1449 L 1449
+
Sbjct: 2538 M 2538
Score = 52.0 bits (123), Expect = 6e-06
Identities = 61/194 (31%), Positives = 69/194 (35%), Gaps = 37/194 (19%)
Query: 55 PARPRGPLICHTGHEQAGREPGP-GSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQG 113
PA P+GP +G + E GP G GP T LP PPGP
Sbjct: 2196 PAGPQGP----SGLKGEPGETGPPGRGLTGP------TGAVGLPGPPGP----------- 2234
Query: 114 RQGSGLGAGPGAGTWAPAPPG-VSKPRCPGR----ARPGEGQQQVTTARP----PAINRG 164
SGL GP P G KP PGR + G+ P P +G
Sbjct: 2235 ---SGL-VGPQGSPGLPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKG 2290
Query: 165 ARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPS-RG-WGAGGRSGAG 222
P A G G AG VGE GA G R P RG G GR+G
Sbjct: 2291 EPGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEP 2350
Query: 223 GDGEDDGPVWIPSP 236
GD +DG P P
Sbjct: 2351 GDPGEDGQKGAPGP 2364
Score = 49.3 bits (116), Expect = 4e-05
Identities = 125/530 (23%), Positives = 175/530 (33%), Gaps = 87/530 (16%)
Query: 435 PGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGL 494
PGP V EP G GE G A GE +NG+ P+ G+ G+
Sbjct: 2090 PGPKVSVDEPGPGL-----SGEQGPPGLKG-------AKGEPGSNGDQGPK----GDRGV 2133
Query: 495 LTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEP 554
D E GP+ + ++G+ PE + Q R + +P
Sbjct: 2134 PGIKGDRGEPGPR--------GQDGNPGLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDP 2185
Query: 555 DS---------CGTQGPVGV--EQVQTQPRGRAARGP-------GSSGTDSTRKPASAVG 596
G QGP G+ E +T P GR GP G G P + G
Sbjct: 2186 GPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPG 2245
Query: 597 TPDKAQKAPGPGPGQEVYFSLKDMYLENTQA---------VRPLGEEGPQTLSVRAPGES 647
P + + PG S KD + V P GE GP APG++
Sbjct: 2246 LPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGP----TGAPGQA 2301
Query: 648 PKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQA 707
G ++G GAPG L +P +R P KGEA +P
Sbjct: 2302 VVGLPG----AKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDG 2357
Query: 708 PECGAQSLG-KAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEV-LECQTTTAPTM 765
+ G K P V P D L G G PG V QT M
Sbjct: 2358 QKGAPGPKGFKGDPGVGVPGSPGPPGPPGVKGDLGLPGLPG--APGVVGFPGQTGPRGEM 2415
Query: 766 SASSSSDVASIGVSTSGSQGIIEPMDMETQED--GRTSANQRTGSK----------KNVQ 813
S + G +GI P+ G A+ G K + +
Sbjct: 2416 GQPGPSGERGLA-GPPGREGIPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGER 2474
Query: 814 ADGKIQ-VDGRTRGDGTQTAQR---TRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRA 869
+ I+ DGR +G + +R +R + D G+ K + D + G A
Sbjct: 2475 GEPGIRGEDGRPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGA 2534
Query: 870 ETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAP 919
+ + GE+ R DKG + D G+KG +GE G + P
Sbjct: 2535 KGDM-----GER--GPRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLP 2577
Score = 48.1 bits (113), Expect = 8e-05
Identities = 65/234 (27%), Positives = 87/234 (37%), Gaps = 37/234 (15%)
Query: 1251 QAGRQALAAARGSWGP-GPSSLTVPAIVVDEEDPGLASEGASEGE-------GEVSPEG- 1301
+ G L + G GP GP ++ PGL + S GE G + P+G
Sbjct: 1422 EPGLPGLPGSPGPQGPVGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGD 1481
Query: 1302 ---PGLLGASQESSMAGRLGEAGGQAAPG----------QGPSAESIAQEPSQEEKFPGE 1348
PG LG + E G G AG + PG +GP + Q E PG+
Sbjct: 1482 RGFPGPLGEAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGEPGRPGD 1541
Query: 1349 -ALTGLPAATPE-----------ELALGARRKRFLPKVRAAGD-GEATTPEERESPTVSP 1395
A+ G A P+ A G + +R P + GD G P +R ++
Sbjct: 1542 PAVVGPAVAGPKGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTG 1601
Query: 1396 RG--PRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAG 1447
R P S PG G PGR G + EV +E GD G KAG
Sbjct: 1602 RAGPPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAG 1655
Score = 45.1 bits (105), Expect = 7e-04
Identities = 70/230 (30%), Positives = 85/230 (36%), Gaps = 39/230 (16%)
Query: 27 PGRGLVLWLPGLP--RSSPSWPAVDLAPLAPARPRGP---------LICHTGHEQAGREP 75
PGR PG P + SP P P PRGP +I G GR+
Sbjct: 1310 PGRAGNPGTPGAPGLKGSPGLPGPRGDP-GERGPRGPKGEPGAPGQVIGGEGPGLPGRKG 1368
Query: 76 GPGSS----TKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPA 131
PG S +GP L D PR P L +G +G GPG G AP
Sbjct: 1369 DPGPSGPPGPRGP-LGDPG------PRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPG 1421
Query: 132 PPGV-SKPRCPGRARP-----GEGQQQVTTARPPAINRGARQPRAGAAAAGRGPGAGAWR 185
PG+ P PG P +G++ + P + QP + RGP
Sbjct: 1422 EPGLPGLPGSPGPQGPVGPPGKKGEKGDSEDGAPGL---PGQPGSPGEQGPRGPPGAIGP 1478
Query: 186 TGEAAASAGPAVGEGGAMGSRRAP----SRGW-GAGGRSGAGGDGEDDGP 230
G+ GP +GE G G R P SRG G GR GA G GP
Sbjct: 1479 KGD-RGFPGP-LGEAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGP 1526
Score = 45.1 bits (105), Expect = 7e-04
Identities = 67/240 (27%), Positives = 82/240 (34%), Gaps = 43/240 (17%)
Query: 1253 GRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEG----EGEVSPEG-PGLLGA 1307
G + + G GP VP I D +PG + + G G PEG PGL G
Sbjct: 2114 GAKGEPGSNGDQGP-KGDRGVPGIKGDRGEPGPRGQDGNPGLPGERGMAGPEGKPGLQGP 2172
Query: 1308 SQESSMAGRLGEAGGQAAPG-------QGPSAESIAQEPSQEEKFPGEALTGLPAATPEE 1360
G G+ G APG QGPS + EP + PG LTG
Sbjct: 2173 RGPPGPVGGHGDPGPPGAPGLAGPAGPQGPSG--LKGEPGETGP-PGRGLTG-------- 2221
Query: 1361 LALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQG 1420
A G P P SP P + G PG PGR+ S G
Sbjct: 2222 ------------PTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGAPGRDGASGKDG 2269
Query: 1421 RKASMLEVPRAEEELAAGDLGPSPKAGGL----DTEVALDEGKQETLAKPRKAKDLLKAP 1476
+ S VP + G +GP + G V L K E A A DL+ P
Sbjct: 2270 DRGSP-GVPGSPG--LPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVGEP 2326
Score = 43.1 bits (100), Expect = 0.003
Identities = 53/181 (29%), Positives = 64/181 (35%), Gaps = 31/181 (17%)
Query: 72 GREPGPGSSTKGPVLHDQDTRCAFLPRPPGP----LQTRRYCRHQGRQGSGLGAGPGAGT 127
GR PGSS GP + P PPGP + T R +G G GP
Sbjct: 1682 GRNGSPGSS--GPKGDRGE------PGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPK 1733
Query: 128 WAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQP-----RAG-----AAAAGR 177
P PG R R G Q R PA +G R P R+G AA
Sbjct: 1734 GDPGLPGAPGERGIEGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAAGPS 1793
Query: 178 GPGAGAWRTGEAAASAGPAV-GEGGAMGSRRAPSRGW--------GAGGRSGAGGDGEDD 228
GP A + G+ P + GE G G P G G++G GD +D
Sbjct: 1794 GPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGED 1853
Query: 229 G 229
G
Sbjct: 1854 G 1854
Score = 42.0 bits (97), Expect = 0.006
Identities = 63/231 (27%), Positives = 72/231 (31%), Gaps = 50/231 (21%)
Query: 36 PGLPRSS----PSWPAVDLAPLAPARPRGP-------LICHTGHEQAGREPGPGSSTKGP 84
PGLP PS P PL PRGP + G PGPG P
Sbjct: 1361 PGLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAP 1420
Query: 85 VLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRA 144
+ LP PGP +G +G PG P PG PR P A
Sbjct: 1421 ----GEPGLPGLPGSPGPQGPVGPPGKKGEKGDSEDGAPGL-PGQPGSPGEQGPRGPPGA 1475
Query: 145 RPGEGQQQVTTARPPAINRGARQPRAGAAAAG-------------RGPGAGAWRTGEAA- 190
+G + A +G R P A + G GP R GE
Sbjct: 1476 IGPKGDRGFPGPLGEAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGE 1535
Query: 191 -------ASAGPAV----GEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGP 230
A GPAV GE G +G AG R G GE P
Sbjct: 1536 PGRPGDPAVVGPAVAGPKGEKGDVGP---------AGPRGATGVQGERGPP 1577
Score = 40.4 bits (93), Expect = 0.017
Identities = 60/219 (27%), Positives = 74/219 (33%), Gaps = 62/219 (28%)
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAK--------KKKKDEESKQGLRKPELEKAA 538
G+DG G+ D +GP R LK E G K K K E G +P L A
Sbjct: 2602 GKDGVPGIRGEKGDVGFMGP-RGLKGERGVKGACGLDGEKGDKGEAGPPG--RPGL--AG 2656
Query: 539 QSRRSSENCIPS-SDEPDSCGTQGPVGVEQVQTQPRGRAARG-------------PGSSG 584
E +P S P G GP G QP + +G PG SG
Sbjct: 2657 HKGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQGEKGERGTPGIGGFPGPSG 2716
Query: 585 TDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAP 644
D + P PGP PG +G GP+ L +
Sbjct: 2717 NDGSAGP-------------PGP-PGS-------------------VGPRGPEGLQGQKG 2743
Query: 645 GESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRK 683
P G+ + A GVPGAPG+ P P P K
Sbjct: 2744 ERGPPGERVVGA--PGVPGAPGERGEQGRPGPAGPRGEK 2780
Score = 40.0 bits (92), Expect = 0.022
Identities = 59/207 (28%), Positives = 72/207 (34%), Gaps = 20/207 (9%)
Query: 1244 GLLDREVQAGRQALAAARGSWGP----GPSSLTVPAIVVDEEDPGLASEGASEGEGEVSP 1299
GL R+ G RG G GP L A+ D+ D G GEG ++P
Sbjct: 1362 GLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGLPGTAMKGDKGDRGERGP-PGPGEGGIAP 1420
Query: 1300 EGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPE 1359
PGL G G +G G + +G S + P Q PG P P
Sbjct: 1421 GEPGLPGLPGSPGPQGPVGPPGKKGE--KGDSEDGAPGLPGQ----PGSPGEQGPRGPPG 1474
Query: 1360 ELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPR-KSLVPGSPGTPGRERRSPT 1418
A+G + R P GEA ER P P G R V G PG G E
Sbjct: 1475 --AIGPKGDRGFP----GPLGEAGEKGERGPP--GPAGSRGLPGVAGRPGAKGPEGPPGP 1526
Query: 1419 QGRKASMLEVPRAEEELAAGDLGPSPK 1445
GR+ E R + G PK
Sbjct: 1527 TGRQGEKGEPGRPGDPAVVGPAVAGPK 1553
Score = 39.7 bits (91), Expect = 0.028
Identities = 61/225 (27%), Positives = 79/225 (35%), Gaps = 48/225 (21%)
Query: 1242 LTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGE------- 1294
L GLL + Q G + GS P VP I ++ D G +GE
Sbjct: 2579 LRGLLGPQGQPGAAGIPGDPGS----PGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGAC 2634
Query: 1295 ---GEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQG--PSAESIAQEPSQEEKFPGEA 1349
GE +G G +AG GE G PGQ P E + P + F G+
Sbjct: 2635 GLDGEKGDKGEA--GPPGRPGLAGHKGEMGEPGVPGQSGAPGKEGLIG-PKGDRGFDGQ- 2690
Query: 1350 LTGLPAATPEELALGARRKRFLPKVR-----AAGDGEATTPEERESPTVSPRGPRK---- 1400
P ++ G + +R P + + DG A P S V PRGP
Sbjct: 2691 ----PGPKGDQ---GEKGERGTPGIGGFPGPSGNDGSAGPPGPPGS--VGPRGPEGLQGQ 2741
Query: 1401 --------SLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAA 1437
V G+PG PG QGR PR E+ AA
Sbjct: 2742 KGERGPPGERVVGAPGVPGAPGERGEQGRPGP--AGPRGEKGEAA 2784
Score = 38.5 bits (88), Expect = 0.063
Identities = 99/423 (23%), Positives = 137/423 (32%), Gaps = 80/423 (18%)
Query: 554 PDSCGTQGPVGVEQVQTQPRGRAARG-------PGSSGTDSTRKPASAVGTPDKAQKAPG 606
P S G QGPVG + + +G + G PGS G R P A+G P + PG
Sbjct: 1429 PGSPGPQGPVGPPGKKGE-KGDSEDGAPGLPGQPGSPGEQGPRGPPGAIG-PKGDRGFPG 1486
Query: 607 PGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPG 666
P LGE G + R P P A S G+PG G
Sbjct: 1487 P-----------------------LGEAGEK--GERGP--------PGPAGSRGLPGVAG 1513
Query: 667 QPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKP--ISSLSQAPECGAQSLGKAPPQASV 724
+P P P R+ KGE P + P+ +G A P+ +
Sbjct: 1514 RPGAKGPEGPPGPTGRQ-----GEKGEPGRPGDPAVVGPAVAGPKGEKGDVGPAGPRGAT 1568
Query: 725 QVP---TPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTS 781
V PP G D +G G R P + P + + G
Sbjct: 1569 GVQGERGPPGLVLPG--DPGPKGDPGDRGP---IGLTGRAGPPGDSGPPGEKGDPG--RP 1621
Query: 782 GSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKT 841
G G + P DG G + GK G G + + D+
Sbjct: 1622 GPPGPVGPRG----RDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQGD 1677
Query: 842 QVD---AGTQESKRPQSDRSAQKGMMTQGR-AETQLETTQAGEKIQEDRKAQADKGTQED 897
+ G+ S P+ DR GR +T + GE DR + +G + D
Sbjct: 1678 PGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKGE--PGDRGQEGPRGPKGD 1735
Query: 898 RRM---QGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPP-----SRTPKLPPTAGP 949
+ GE+G++G +G P E+ GPP S P AGP
Sbjct: 1736 PGLPGAPGERGIEGFRGPPGPQGDPGVRGPAGEK---GDRGPPGLDGRSGLDGKPGAAGP 1792
Query: 950 RAP 952
P
Sbjct: 1793 SGP 1795
Score = 38.5 bits (88), Expect = 0.063
Identities = 62/231 (26%), Positives = 75/231 (32%), Gaps = 53/231 (22%)
Query: 14 PLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLA--PARPRGPLICHTGHEQA 71
PL GE R PG P S P V P A P P GP TG +
Sbjct: 1487 PLGEAGEKGERGPPG----------PAGSRGLPGVAGRPGAKGPEGPPGP----TGRQGE 1532
Query: 72 GREPG-PGS-STKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWA 129
EPG PG + GP + GP +G +G AGP T
Sbjct: 1533 KGEPGRPGDPAVVGPAV-------------AGP---------KGEKGDVGPAGPRGATGV 1570
Query: 130 PA---PPGVSKPRCPG-RARPGEGQQQVTTAR--------PPAINRGARQPRAGAAAAGR 177
PPG+ P PG + PG+ T R PP +P R
Sbjct: 1571 QGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPGPPGPVGPR 1630
Query: 178 GPGAGAWRTGEAAASAGPAV-GEGGAMGSRRAPSRGWGAGGRSGAGGDGED 227
G G+ P + G+ G G R AP G + G GED
Sbjct: 1631 GRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQGDPGED 1681
Score = 37.0 bits (84), Expect = 0.18
Identities = 53/184 (28%), Positives = 72/184 (39%), Gaps = 27/184 (14%)
Query: 1253 GRQALAAARGSWG-PGPSSLT-VPAIVVDEEDPGLASEGASEGE----GEV-SPEGPGLL 1305
GR G+ G PG L P + DPG +GE G+V EGPGL
Sbjct: 1305 GRPGSPGRAGNPGTPGAPGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLP 1364
Query: 1306 GASQESSMAGR------LGEAGGQAAPG---------QGPSAESIAQEPSQEEKFPGE-A 1349
G + +G LG+ G + PG +G E P + PGE
Sbjct: 1365 GRKGDPGPSGPPGPRGPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPG 1424
Query: 1350 LTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESP-TVSPRGPRKSLVP-GSP 1407
L GLP + + +G K+ + + DG P + SP PRGP ++ P G
Sbjct: 1425 LPGLPGSPGPQGPVGPPGKK--GEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDR 1482
Query: 1408 GTPG 1411
G PG
Sbjct: 1483 GFPG 1486
Score = 33.5 bits (75), Expect = 2.0
Identities = 47/179 (26%), Positives = 57/179 (31%), Gaps = 45/179 (25%)
Query: 1282 DPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQ 1341
DPGL + G PG+ G E G GE G +PG + P
Sbjct: 1647 DPGLPGKAGERG----LRGAPGVRGPVGEKGDQGDPGEDGRNGSPG--------SSGPKG 1694
Query: 1342 EEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKS 1401
+ PG P P L G G E + PRGP+
Sbjct: 1695 DRGEPG------PPGPPGRLV-------------DTGPGAREKGEPGDRGQEGPRGPKGD 1735
Query: 1402 LVPGSPGTPGRER----RSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALD 1456
PG PG PG R P + + P E+ GD GP GLD LD
Sbjct: 1736 --PGLPGAPGERGIEGFRGPPGPQGDPGVRGPAGEK----GDRGPP----GLDGRSGLD 1784
Score = 33.1 bits (74), Expect = 2.7
Identities = 39/129 (30%), Positives = 44/129 (34%), Gaps = 16/129 (12%)
Query: 113 GRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPA----INRGARQP 168
G QG GP G P PPG PG A P Q P RG P
Sbjct: 2168 GLQGPRGPPGPVGGHGDPGPPG-----APGLAGPAGPQGPSGLKGEPGETGPPGRGLTGP 2222
Query: 169 RAGAAAAGRGPGAGAWRTGEAAASAGPAV-GEGGAMGSRRAPSRGWGAGGRSGAGGDGED 227
GA PG +G P + G+ G G AP R GA G+ G G
Sbjct: 2223 -TGAVGLPGPPGP----SGLVGPQGSPGLPGQVGETGKPGAPGRD-GASGKDGDRGSPGV 2276
Query: 228 DGPVWIPSP 236
G +P P
Sbjct: 2277 PGSPGLPGP 2285
Score = 32.7 bits (73), Expect = 3.5
Identities = 44/166 (26%), Positives = 59/166 (35%), Gaps = 37/166 (22%)
Query: 100 PGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPR---------CPG----RARP 146
PGP R GR+G GP + PPG S + PG R P
Sbjct: 2418 PGPSGERGLAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEP 2477
Query: 147 G-------EGQQQVTTARPPAINRGARQPRAGAAAAG-RGPGAGAWRTGEAAASAGP--- 195
G GQ+ P +RG R + +AG +G G++A GP
Sbjct: 2478 GIRGEDGRPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGD------KGDSAVILGPPGP 2531
Query: 196 --AVGEGGAMGSR-----RAPSRGWGAGGRSGAGGDGEDDGPVWIP 234
A G+ G G R + P G G G+ G+ D G +P
Sbjct: 2532 RGAKGDMGERGPRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLP 2577
Score = 32.3 bits (72), Expect = 4.5
Identities = 54/207 (26%), Positives = 63/207 (30%), Gaps = 20/207 (9%)
Query: 39 PRSSPSWPAVDLAPLAPARPRGPLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAFLPR 98
P P P AP P P G G + PGS + A P
Sbjct: 1270 PPGDPGLPGRTGAP-GPQGPPGSATAKGERGFPGADGRPGSPGR-----------AGNPG 1317
Query: 99 PPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGV----SKPRCPGRARPGEGQQQVT 154
PG + G +G GP P PG P PGR + G
Sbjct: 1318 TPGAPGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLPGR-KGDPGPSGPP 1376
Query: 155 TARPPAINRGARQPRAGAAAAGRGP-GAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGW 213
R P + G R P A +G G R G A GE G G +P
Sbjct: 1377 GPRGPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQG 1436
Query: 214 GAG--GRSGAGGDGEDDGPVWIPSPAS 238
G G+ G GD ED P P S
Sbjct: 1437 PVGPPGKKGEKGDSEDGAPGLPGQPGS 1463
Score = 31.6 bits (70), Expect = 7.7
Identities = 39/158 (24%), Positives = 53/158 (33%), Gaps = 15/158 (9%)
Query: 97 PRP-PGPLQTRRYCRHQ-GRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVT 154
PRP P P+ + + + G G GP P G P+ P + +G++
Sbjct: 1242 PRPEPCPVYCPKGQKGEPGEMGLRGQVGPPGDPGLPGRTGAPGPQGPPGSATAKGERGFP 1301
Query: 155 TA--RPPAINRGARQPRAGAAAAGRGPGAGAWR-----------TGEAAASAGPAVGEGG 201
A RP + R GA PG R GE A GEG
Sbjct: 1302 GADGRPGSPGRAGNPGTPGAPGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGP 1361
Query: 202 AMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASR 239
+ R+ G G G GD GP +P A +
Sbjct: 1362 GLPGRKGDPGPSGPPGPRGPLGDPGPRGPPGLPGTAMK 1399
>gi|155969693 myomesin family, member 3 [Homo sapiens]
Length = 1437
Score = 64.3 bits (155), Expect = 1e-09
Identities = 35/87 (40%), Positives = 48/87 (55%), Gaps = 1/87 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD-RYCGLPKYEITHQGNRH 337
P F L+S +V E + V TC V P P+VTWYK+DT +D R KY IT+
Sbjct: 154 PWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLL 213
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVS 364
+L++ RC ED+A Y +N+ G S
Sbjct: 214 SLEIRRCAIEDSATYTVRVKNAHGQAS 240
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 9/76 (11%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDD---TELDRYCGLPKYEITHQGNRHTLQLYRCR 345
++ ED + TCIV+G P PE++W K+D T LDRY + E+ +G T+ + +
Sbjct: 1345 TIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRY----RMEV--RGTEVTITIEKVN 1398
Query: 346 EEDAAIYQASAQNSKG 361
ED+ Y +N G
Sbjct: 1399 SEDSGRYGVFVKNKYG 1414
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 62.8 bits (151), Expect = 3e-09
Identities = 210/1023 (20%), Positives = 355/1023 (34%), Gaps = 176/1023 (17%)
Query: 474 GEVTTNGEAAPENGEDGEHGLL-TYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKP 532
G+ + E++ E D G + T + A E L+ + + K + K G
Sbjct: 539 GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAV 597
Query: 533 ELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARG---PGSSGTDSTR 589
++ KA + +SE+ SSD DS + P + Q +P + + P + T ++
Sbjct: 598 QV-KAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASA 654
Query: 590 KPASA-VGT--PDKAQKAPGP-GPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPG 645
K A VGT P KA A P G V + +++ + EE L+V
Sbjct: 655 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 714
Query: 646 ESPKGKA-PLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSL 704
GK ++A S V G+ GQ T + P T P + A + E++ +
Sbjct: 715 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 774
Query: 705 SQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDS-----TLQGQAGHRTPGEVLE-CQ 758
+ +P S+ K +A+ P+ + GT + T QA R+P +V +
Sbjct: 775 AASPAQVKTSVKKTQAKANPAAARAPSAK--GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 759 TTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKI 818
T+ A + V S+G + + T+A +TG +++ G
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVA------------------TAAQAQTGPEED---SGSS 871
Query: 819 QVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQA 878
+ + + + AQ + + Q+ A +K S +KG +T QA
Sbjct: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKE-----SPRKGAAPTPPGKTGPSAAQA 926
Query: 879 GEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPS 938
G+ Q D G+ + + S+G AP A+ + P+
Sbjct: 927 GK--------QDDSGSSSEE-------------SDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 939 RTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSG 998
R+P AGP A TP + P SE ++S E + P +
Sbjct: 966 RSP-----AGPAA---------TPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQ 1011
Query: 999 NLM---------LPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGV 1049
L +P P + G +SS + K+++ P ++ P +
Sbjct: 1012 CLTPGIRTNVVTMPTAHPRIAPKASMAGASS-SKESSRISDGKKQEGPATQVSKKNPASL 1070
Query: 1050 PCMDQGGCPLAGLSQEV--PTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLPSEDQVL 1107
P LA + E P + P +G+ ++ P ++P S
Sbjct: 1071 PLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQS---------------- 1114
Query: 1108 MSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLL 1167
T GT P ++P+V+ T P S D S +
Sbjct: 1115 -----TSVQAKGTNKLRKP-------------KLPEVQQATKAPESSDDSEDSSDSS--- 1153
Query: 1168 LLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQ 1227
S +E G G + A T G PS T T E A S + +V
Sbjct: 1154 -----SGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES-----------SEDDVVA 1197
Query: 1228 SAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDP-GLA 1286
+Q+LL T GL QA + SS +V + + ++DP G
Sbjct: 1198 PSQSLLSGYMT----PGLTPANSQASKATPKL--------DSSPSVSSTLAAKDDPDGKQ 1245
Query: 1287 SEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFP 1346
+ G +SP+ G AS + R + G P A ++A + + +
Sbjct: 1246 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG-----AGNPQASTLALQSNITQCLL 1300
Query: 1347 GE-------ALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPR 1399
G+ + EL R+K ++ G + + + R PR
Sbjct: 1301 GQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPR 1360
Query: 1400 -KSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEG 1458
K G G SP K S +A+ + A+GD+ G L ++ A DE
Sbjct: 1361 SKKKKKLGAGEGGEASVSP---EKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEP 1417
Query: 1459 KQE 1461
++E
Sbjct: 1418 EEE 1420
Score = 50.4 bits (119), Expect = 2e-05
Identities = 237/1159 (20%), Positives = 390/1159 (33%), Gaps = 202/1159 (17%)
Query: 385 AKLKRKAAAKLREIEQSWKHEKAVPGEVD--TLRKLSPDRFQRKRRLSGAQAPGPSVPTR 442
+ +K KA A E E++ K ++P T+ L + RK S + ++ +
Sbjct: 119 SSMKEKAKA---ETEKAGKTGNSMPHPATGKTVANLLSGKSPRK---SAEPSANTTLVSE 172
Query: 443 EPEGGTL----AAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYI 498
E G++ AA + G Q S +S E G+ + + + + T
Sbjct: 173 TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232
Query: 499 CDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCG 558
A + P + + K + +KPE E++ S SE S+E G
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE-EESESSEEGSE-----SEEEAPAG 286
Query: 559 TQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLK 618
T+ V + Q R +A G+ G +T P G KA P E
Sbjct: 287 TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346
Query: 619 DMYLENTQAVRPLGEEGPQTLSVRAPGE-SPKGKAPLRARSEGVPGAPGQPTHSLTPQPT 677
E T A + L L +A G+ S G A A+ GA P P T
Sbjct: 347 SDSEEETPAAKAL-------LQAKASGKTSQVGAASAPAKESPRKGAAPAP-----PGKT 394
Query: 678 RPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGT 737
P K A K + ++ + S+ S +AP A+ GKAP + P
Sbjct: 395 GPAVAKAQA-GKREEDSQSSSEESDSEEEAP-AQAKPSGKAPQVRAASAP---------A 443
Query: 738 RDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQED 797
++S +G A AP ++ +G + +ED
Sbjct: 444 KESPRKGAA--------------PAPPRKTGPAAAQVQVG---------------KQEED 474
Query: 798 GRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDR 857
R+S+ + ++ + A QV K PQ
Sbjct: 475 SRSSSEESDSDREALAAMNAAQV--------------------------KPLGKSPQVKP 508
Query: 858 SAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGS 917
++ GM G+ + + G AQ K +ED E E S+G
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPATP---SAQVGK-WEEDSESSSE-----ESSDSSDGE 559
Query: 918 APTAMEGQSEQEVATSL--GPPSRTPKLPP-TAGPRA-------PL-NIECFVQTPEGSC 966
PTA+ E+ + L P S K PP AGP A P+ N E ++ + +
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSAD 619
Query: 967 FPKKPGCLPRSE---------------EAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGS 1011
+ P + ++ + TAS +G + A P S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679
Query: 1012 VEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPS 1071
GG + SS E+ E EE+ G + Q GL + ++P
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSE--------EEKTGLAVTVGQAKSVGKGLQVKAASVPV 731
Query: 1072 LPGTGLTASP----KAGPCSTPT---SQHGSTATFLPSEDQVLMSSAPTLHLGL-GTPTQ 1123
G +P K GP T Q S ++ S+ + +S + + T +
Sbjct: 732 KGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 1124 SHPPETMATSSEGACAQVPDV-----EGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETS 1178
++P A S++G + V + + P P + + +N +L +S +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSV 850
Query: 1179 GAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCT 1238
G + A TG E +G S E + + A+TL
Sbjct: 851 GKAVATAAQAQTG----------PEEDSGSSE----------EESDSEEEAETL-----A 885
Query: 1239 SRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVP--AIVVDEEDPGLASEGA-SEGEG 1295
+ +G + A A + R P P T P A ++D G +SE + S+GE
Sbjct: 886 QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEA 945
Query: 1296 EVSPEG-----PGLLGASQESSMAGRL---GEAGGQAAPGQGPSAESIAQ----EPSQEE 1343
+ P L+ S AG +A + P + ++ES A+ E E+
Sbjct: 946 PAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDED 1005
Query: 1344 KFPG-EALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSL 1402
P + LT P + + R PK AG ++ R S GP +
Sbjct: 1006 VIPATQCLT--PGIRTNVVTMPTAHPRIAPKASMAG-ASSSKESSRISDGKKQEGPATQV 1062
Query: 1403 VPGSPGT-PGRERRSPTQGRKASMLEVPRAEEELAAG---DLGPSPKAGGLDTEVALDEG 1458
+P + P + +KAS + P A + ++G +G P T V
Sbjct: 1063 SKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGT 1122
Query: 1459 KQETLAKPRKAKDLLKAPQ 1477
+ K + + KAP+
Sbjct: 1123 NKLRKPKLPEVQQATKAPE 1141
Score = 46.2 bits (108), Expect = 3e-04
Identities = 97/454 (21%), Positives = 164/454 (36%), Gaps = 85/454 (18%)
Query: 484 PENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRS 543
P +G D G L PQ + G K LRKP+L + Q+ ++
Sbjct: 1096 PSSGVDSAVGTLP------ATSPQSTSVQAKGTNK----------LRKPKLPEVQQATKA 1139
Query: 544 SENCIPSSDEPDSCG-----TQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTP 598
E+ S D DS +GP G + T GP S T++ + +A +
Sbjct: 1140 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT-------LGPTPSRTETLVEETAAESSE 1192
Query: 599 DKAQKAPGPGPGQEVY--FSLKDMYLENTQAVR--PLGEEGPQTLSVRAPGESPKGK--- 651
D P Q + + + N+QA + P + P S A + P GK
Sbjct: 1193 DDV-----VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEA 1247
Query: 652 APLRARSEGVPGAPGQPTHS-LTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPEC 710
P +A P G+ S TPQ +R PK KG + ++ S +C
Sbjct: 1248 KPQQAAGMLSPKTGGKEAASGTTPQKSR--------KPK-KGAGNPQASTLALQSNITQC 1298
Query: 711 ---GAQSLGKAPPQAS-VQVPTPPARRRH-----GTRDSTLQGQAGHRTPGEVLECQTTT 761
L +A QAS V+V T + T++S+ +G + +
Sbjct: 1299 LLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGD 1352
Query: 762 APTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVD 821
P S +G G + + P T G+ ++ +G K + G +
Sbjct: 1353 QPAARTPRSKKKKKLGAG-EGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL--- 1408
Query: 822 GRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEK 881
G+Q A + + + Q GT E D+S K + E + + +K
Sbjct: 1409 ------GSQGA-KDEPEEELQKGMGTVEG----GDQSNPK-----SKKEKKKSDKRKKDK 1452
Query: 882 IQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSE 915
++++K +A K + +D +K + +K T +
Sbjct: 1453 EKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1486
Score = 37.7 bits (86), Expect = 0.11
Identities = 112/548 (20%), Positives = 176/548 (32%), Gaps = 88/548 (16%)
Query: 410 GEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLIN 469
G + K+ Q K+R P P R P+ T+ A + + +
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKP----PVRNPQNSTVLARGPASVPSVGKA-VATAA 858
Query: 470 SFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGL 529
+G +G + E+ + E L + + + RA + +K + G
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 530 RKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTR 589
P +A + S SS+E DS G + P V Q P D R
Sbjct: 919 TGPSAAQAGKQDDSGS----SSEESDSDG-EAPAAVTSAQVIK-------PPLIFVDPNR 966
Query: 590 KPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPK 649
PA TP +AQ A P RA + +
Sbjct: 967 SPAGPAATPAQAQAASTP-------------------------------RKARASESTAR 995
Query: 650 GKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLS--QA 707
+ + +P T T P R A PK + SK S +S +
Sbjct: 996 SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA-PKASMAGASSSKESSRISDGKK 1054
Query: 708 PECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSA 767
E A + K P AS+ + T A + + S Q P ++ T P S
Sbjct: 1055 QEGPATQVSKKNP-ASLPL-TQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSP 1112
Query: 768 SSSSDVASIGVSTSGSQGIIEPMDMETQ---------EDGRTSANQRTGSKKNVQADGKI 818
S+S V G+ + +P E Q +D S++ +GS++ DG
Sbjct: 1113 QSTS------VQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEE----DG-- 1160
Query: 819 QVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQ---SDRSAQKGMMTQGRAETQLET 875
+G T T + +T V+ ES +S G MT G +
Sbjct: 1161 --EGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQA 1218
Query: 876 TQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLG 935
++A K+ + ++D G Q K Q+ G G +E A+
Sbjct: 1219 SKATPKLDSSPSVSSTLAAKDD-----PDGKQEAKPQQAAGMLSPKTGG---KEAASGTT 1270
Query: 936 P-PSRTPK 942
P SR PK
Sbjct: 1271 PQKSRKPK 1278
Score = 33.9 bits (76), Expect = 1.6
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 412 VDTLRKLSPDRFQ-RKRRLSGAQAPGPSVPTREPEGGTLAAWQEGET-----ETAQHSGL 465
VDT ++ S ++ RKR+LSG Q P P R + L A + GE +T+ S
Sbjct: 1331 VDTTKESSRKGWESRKRKLSGDQ-PAARTP-RSKKKKKLGAGEGGEASVSPEKTSTTSKG 1388
Query: 466 GLINSFASGEVTTN---GEAAPENGEDGEHGLLTYICDAMELGPQ---RALKEESGAKKK 519
ASG+V G + +D L +E G Q ++ KE+ + K+
Sbjct: 1389 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1448
Query: 520 KKDEESKQGLRKPELEKAAQSRRSSE 545
KKD+E K+ +K + S S+
Sbjct: 1449 KKDKEKKEKKKKAKKASTKDSESPSQ 1474
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 62.8 bits (151), Expect = 3e-09
Identities = 210/1023 (20%), Positives = 355/1023 (34%), Gaps = 176/1023 (17%)
Query: 474 GEVTTNGEAAPENGEDGEHGLL-TYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKP 532
G+ + E++ E D G + T + A E L+ + + K + K G
Sbjct: 462 GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAV 520
Query: 533 ELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARG---PGSSGTDSTR 589
++ KA + +SE+ SSD DS + P + Q +P + + P + T ++
Sbjct: 521 QV-KAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASA 577
Query: 590 KPASA-VGT--PDKAQKAPGP-GPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPG 645
K A VGT P KA A P G V + +++ + EE L+V
Sbjct: 578 KVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQ 637
Query: 646 ESPKGKA-PLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSL 704
GK ++A S V G+ GQ T + P T P + A + E++ +
Sbjct: 638 AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697
Query: 705 SQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDS-----TLQGQAGHRTPGEVLE-CQ 758
+ +P S+ K +A+ P+ + GT + T QA R+P +V +
Sbjct: 698 AASPAQVKTSVKKTQAKANPAAARAPSAK--GTISAPGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 759 TTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKI 818
T+ A + V S+G + + T+A +TG +++ G
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVA------------------TAAQAQTGPEED---SGSS 794
Query: 819 QVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQA 878
+ + + + AQ + + Q+ A +K S +KG +T QA
Sbjct: 795 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKE-----SPRKGAAPTPPGKTGPSAAQA 849
Query: 879 GEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPS 938
G+ Q D G+ + + S+G AP A+ + P+
Sbjct: 850 GK--------QDDSGSSSEE-------------SDSDGEAPAAVTSAQVIKPPLIFVDPN 888
Query: 939 RTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSG 998
R+P AGP A TP + P SE ++S E + P +
Sbjct: 889 RSP-----AGPAA---------TPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQ 934
Query: 999 NLM---------LPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGV 1049
L +P P + G +SS + K+++ P ++ P +
Sbjct: 935 CLTPGIRTNVVTMPTAHPRIAPKASMAGASS-SKESSRISDGKKQEGPATQVSKKNPASL 993
Query: 1050 PCMDQGGCPLAGLSQEV--PTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLPSEDQVL 1107
P LA + E P + P +G+ ++ P ++P S
Sbjct: 994 PLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQS---------------- 1037
Query: 1108 MSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLL 1167
T GT P ++P+V+ T P S D S +
Sbjct: 1038 -----TSVQAKGTNKLRKP-------------KLPEVQQATKAPESSDDSEDSSDSS--- 1076
Query: 1168 LLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQ 1227
S +E G G + A T G PS T T E A S + +V
Sbjct: 1077 -----SGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES-----------SEDDVVA 1120
Query: 1228 SAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDP-GLA 1286
+Q+LL T GL QA + SS +V + + ++DP G
Sbjct: 1121 PSQSLLSGYMT----PGLTPANSQASKATPKL--------DSSPSVSSTLAAKDDPDGKQ 1168
Query: 1287 SEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFP 1346
+ G +SP+ G AS + R + G P A ++A + + +
Sbjct: 1169 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG-----AGNPQASTLALQSNITQCLL 1223
Query: 1347 GE-------ALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPR 1399
G+ + EL R+K ++ G + + + R PR
Sbjct: 1224 GQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPR 1283
Query: 1400 -KSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEG 1458
K G G SP K S +A+ + A+GD+ G L ++ A DE
Sbjct: 1284 SKKKKKLGAGEGGEASVSP---EKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEP 1340
Query: 1459 KQE 1461
++E
Sbjct: 1341 EEE 1343
Score = 61.6 bits (148), Expect = 7e-09
Identities = 168/786 (21%), Positives = 261/786 (33%), Gaps = 141/786 (17%)
Query: 753 EVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNV 812
E E +T A AS++S V + P M+ + T +TG+
Sbjct: 92 EEAEAETAKATPRLASTNSSVLGADL----------PSSMKEKAKAETEKAGKTGNSMPH 141
Query: 813 QADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQ 872
A GK V G + + A+ T V +E P +A+ GM++ G+A++
Sbjct: 142 PATGKT-VANLLSGKSPRKSAEPSANT-TLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 873 LETT-----------QAGEKIQEDRKAQAD-KGTQEDRRMQGEKGMQGEKGTQ------- 913
E T +A EKI + R A A KGT G G +Q
Sbjct: 200 SEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE 259
Query: 914 --SEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKP 971
SE S+ + + + E A +L + K AP ++P P P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK-----ESPRKGAAPAPP 314
Query: 972 GCL-PRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQV------------GGE 1018
G P +A Q+ PAQ G QV G
Sbjct: 315 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA 374
Query: 1019 RCRGPQSSGPVEA-----KQEDSPFQCPKEERPG--GVPCMDQGGCPLAGLSQEV---PT 1068
P+ +GP A KQE+ +E + M+ G S +V T
Sbjct: 375 APAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 434
Query: 1069 M---PSLPGTGLTASPKAGPCSTPTSQHG---------STATFLPSEDQVLMSSAPTLHL 1116
M P G G K GP +TP++Q G S + S+ +V + AP
Sbjct: 435 MGMGPLGKGAGPVPPGKVGP-ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 493
Query: 1117 GLGTPTQSHPPETMATSSEGACAQVP-DVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSST 1175
LG Q+ P + A V V+ P S SS
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS------------------ESSE 535
Query: 1176 ETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLS 1235
E+S + + AA + +A P +++ P+T
Sbjct: 536 ESSDSADSEEAPAA----MTAAQAKPALKI----PQTK--------------------AC 567
Query: 1236 PCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGE- 1294
P + V+ G QA A + P SS PA+ + P S + E +
Sbjct: 568 PKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS---PAVAGGTQRPAEDSSSSEESDS 624
Query: 1295 -----------GEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQ-GPSAESI-AQEPSQ 1341
G+ G GL + + G LG+ PG+ GP+ + A++
Sbjct: 625 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 684
Query: 1342 EEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKS 1401
E E+ + AA+P ++ ++ + AA A V+ K
Sbjct: 685 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 744
Query: 1402 LVPGSPGTPGRERRSPTQGRK--ASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGK 1459
P P R ++ T + AS+ V +A A GP +G + E +E +
Sbjct: 745 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE-E 803
Query: 1460 QETLAK 1465
ETLA+
Sbjct: 804 AETLAQ 809
Score = 51.2 bits (121), Expect = 9e-06
Identities = 211/1007 (20%), Positives = 337/1007 (33%), Gaps = 189/1007 (18%)
Query: 531 KPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRK 590
KP + A Q+ SSE+ SSDE D V + Q R +A G+ G +T
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDV-----EVKASEKILQVRAASAPAKGTPGKGATPA 241
Query: 591 PASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGE-SPK 649
P G KA P E E T A + L L +A G+ S
Sbjct: 242 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL-------LQAKASGKTSQV 294
Query: 650 GKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPE 709
G A A+ GA P P T P K A K + ++ + S+ S +AP
Sbjct: 295 GAASAPAKESPRKGAAPAP-----PGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAP- 347
Query: 710 CGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASS 769
A+ GKAP + P ++S +G A AP
Sbjct: 348 AQAKPSGKAPQVRAASAP---------AKESPRKGAA--------------PAPPRKTGP 384
Query: 770 SSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGT 829
++ +G + +ED R+S+ + ++ + A QV
Sbjct: 385 AAAQVQVG---------------KQEEDSRSSSEESDSDREALAAMNAAQV--------- 420
Query: 830 QTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQ 889
K PQ ++ GM G+ + + G AQ
Sbjct: 421 -----------------KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATP---SAQ 460
Query: 890 ADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSL--GPPSRTPKLPP-T 946
K +ED E E S+G PTA+ E+ + L P S K PP
Sbjct: 461 VGK-WEEDSESSSE-----ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 514
Query: 947 AGPRA-------PL-NIECFVQTPEGSCFPKKPGCLPRSE---------------EAVVT 983
AGP A P+ N E ++ + + + P + ++ + T
Sbjct: 515 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 984 ASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKE 1043
AS +G + A P S GG + SS E+ E E
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSE--------E 626
Query: 1044 ERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASP----KAGPCSTPT---SQHGST 1096
E+ G + Q GL + ++P G +P K GP T Q S
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 1097 ATFLPSEDQVLMSSAPTLHLGL-GTPTQSHPPETMATSSEGACAQVPDV-----EGRTPG 1150
++ S+ + +S + + T +++P A S++G + V + +
Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 746
Query: 1151 PRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSP 1210
P P + + +N +L +S + G + A TG E +G S
Sbjct: 747 PSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQAQTG----------PEEDSGSSE 795
Query: 1211 RTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSS 1270
E + + A+TL + +G + A A + R P P
Sbjct: 796 ----------EESDSEEEAETL-----AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPG 840
Query: 1271 LTVP--AIVVDEEDPGLASEGA-SEGEGEVSPEG-----PGLLGASQESSMAGRL---GE 1319
T P A ++D G +SE + S+GE + P L+ S AG +
Sbjct: 841 KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ 900
Query: 1320 AGGQAAPGQGPSAESIAQ----EPSQEEKFPG-EALTGLPAATPEELALGARRKRFLPKV 1374
A + P + ++ES A+ E E+ P + LT P + + R PK
Sbjct: 901 AQAASTPRKARASESTARSSSSESEDEDVIPATQCLT--PGIRTNVVTMPTAHPRIAPKA 958
Query: 1375 RAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGT-PGRERRSPTQGRKASMLEVPRAEE 1433
AG ++ R S GP + +P + P + +KAS + P A
Sbjct: 959 SMAG-ASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVART 1017
Query: 1434 ELAAG---DLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQ 1477
+ ++G +G P T V + K + + KAP+
Sbjct: 1018 QPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPE 1064
Score = 46.2 bits (108), Expect = 3e-04
Identities = 97/454 (21%), Positives = 164/454 (36%), Gaps = 85/454 (18%)
Query: 484 PENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRS 543
P +G D G L PQ + G K LRKP+L + Q+ ++
Sbjct: 1019 PSSGVDSAVGTLP------ATSPQSTSVQAKGTNK----------LRKPKLPEVQQATKA 1062
Query: 544 SENCIPSSDEPDSCG-----TQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTP 598
E+ S D DS +GP G + T GP S T++ + +A +
Sbjct: 1063 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT-------LGPTPSRTETLVEETAAESSE 1115
Query: 599 DKAQKAPGPGPGQEVY--FSLKDMYLENTQAVR--PLGEEGPQTLSVRAPGESPKGK--- 651
D P Q + + + N+QA + P + P S A + P GK
Sbjct: 1116 DDV-----VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEA 1170
Query: 652 APLRARSEGVPGAPGQPTHS-LTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPEC 710
P +A P G+ S TPQ +R PK KG + ++ S +C
Sbjct: 1171 KPQQAAGMLSPKTGGKEAASGTTPQKSR--------KPK-KGAGNPQASTLALQSNITQC 1221
Query: 711 ---GAQSLGKAPPQAS-VQVPTPPARRRH-----GTRDSTLQGQAGHRTPGEVLECQTTT 761
L +A QAS V+V T + T++S+ +G + +
Sbjct: 1222 LLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGD 1275
Query: 762 APTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVD 821
P S +G G + + P T G+ ++ +G K + G +
Sbjct: 1276 QPAARTPRSKKKKKLGAG-EGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL--- 1331
Query: 822 GRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEK 881
G+Q A + + + Q GT E D+S K + E + + +K
Sbjct: 1332 ------GSQGA-KDEPEEELQKGMGTVEG----GDQSNPK-----SKKEKKKSDKRKKDK 1375
Query: 882 IQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSE 915
++++K +A K + +D +K + +K T +
Sbjct: 1376 EKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1409
Score = 33.9 bits (76), Expect = 1.6
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 412 VDTLRKLSPDRFQ-RKRRLSGAQAPGPSVPTREPEGGTLAAWQEGET-----ETAQHSGL 465
VDT ++ S ++ RKR+LSG Q P P R + L A + GE +T+ S
Sbjct: 1254 VDTTKESSRKGWESRKRKLSGDQ-PAARTP-RSKKKKKLGAGEGGEASVSPEKTSTTSKG 1311
Query: 466 GLINSFASGEVTTN---GEAAPENGEDGEHGLLTYICDAMELGPQ---RALKEESGAKKK 519
ASG+V G + +D L +E G Q ++ KE+ + K+
Sbjct: 1312 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1371
Query: 520 KKDEESKQGLRKPELEKAAQSRRSSE 545
KKD+E K+ +K + S S+
Sbjct: 1372 KKDKEKKEKKKKAKKASTKDSESPSQ 1397
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 62.4 bits (150), Expect = 4e-09
Identities = 189/950 (19%), Positives = 313/950 (32%), Gaps = 127/950 (13%)
Query: 537 AAQSRRSSENCIPSSDEP-DSCGTQGPVGVEQVQTQPRGRAARG-PGSSGTDSTRKPASA 594
+AQ + E+ SS+E DS + P V Q + G + P SS + A
Sbjct: 535 SAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGP 594
Query: 595 VGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGK--- 651
V KA+K E D E A + P L + PK
Sbjct: 595 VAVQVKAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKP-ALKIPQTKACPKKTNTT 651
Query: 652 -----APLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQ 706
AP+R ++ P G T P +R A E + + + L+
Sbjct: 652 ASAKVAPVRVGTQA-PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710
Query: 707 APECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMS 766
A+S+GK + VP ++G G T + T +
Sbjct: 711 TVG-QAKSVGKGLQVKAASVP--------------VKGSLGQGTAPVLPGKTGPTVTQVK 755
Query: 767 ASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRG 826
A D S + + P ++T +T A + + A G I G+
Sbjct: 756 AEKQEDSESSEEESDSEEAAASPAQVKTSVK-KTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 827 DGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDR 886
Q QR+ + K V + PQ+ +G + + T
Sbjct: 815 AAAQAKQRSPSKVKPPV-------RNPQNSTVLARGPASVPSVGKAVATA---------- 857
Query: 887 KAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPK---L 943
AQA G +ED G + + ++E A G++ Q + +L P +P+
Sbjct: 858 -AQAQTGPEED---SGSSEEESDSEEEAETLAQVKPSGKTHQ-IRAALAPAKESPRKGAA 912
Query: 944 PPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLP 1003
P G P + Q GS + + A+ Q + PL + P
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEES------DSDGEAPAAVTSAQVIKPPLI--FVDP 964
Query: 1004 AQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLS 1063
+ P + + P+ + E+ S + E+ C+ G +
Sbjct: 965 NRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG------IR 1018
Query: 1064 QEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQ 1123
V TMP TA P+ P ++ S + S+ + A + +GT
Sbjct: 1019 TNVVTMP-------TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPA 1071
Query: 1124 SHPPETMATS---SEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGA 1180
+ P T + ++ ++P+V+ T P S D S + S +E G
Sbjct: 1072 TSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS--------SGSEEDGE 1123
Query: 1181 GGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSR 1240
G + A T G PS T T E A S + +V +Q+LL T
Sbjct: 1124 GPQGAKSAHTLGPTPSRTETLVEETAAES-----------SEDDVVAPSQSLLSGYMT-- 1170
Query: 1241 RLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDP-GLASEGASEGEGEVSP 1299
GL QA + SS +V + + ++DP G + G +SP
Sbjct: 1171 --PGLTPANSQASKATPKL--------DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1220
Query: 1300 EGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFPGE-------ALTG 1352
+ G AS + R + G P A ++A + + + G+ +
Sbjct: 1221 KTGGKEAASGTTPQKSRKPKKG-----AGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1275
Query: 1353 LPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPR-KSLVPGSPGTPG 1411
EL R+K ++ G + + + R PR K G G
Sbjct: 1276 SVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGG 1335
Query: 1412 RERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQE 1461
SP K S +A+ + A+GD+ G L ++ A DE ++E
Sbjct: 1336 EASVSP---EKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEE 1382
Score = 57.4 bits (137), Expect = 1e-07
Identities = 160/779 (20%), Positives = 262/779 (33%), Gaps = 134/779 (17%)
Query: 752 GEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIE--PMDMETQEDGRTSANQRTGSK 809
G V P M ++ +D +S S+S + +E P Q + + + + ++
Sbjct: 177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Query: 810 KNVQADGKI-QVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGR 868
K A GK+ V + +G A+R + K + ++ + E + +S+ A G +Q
Sbjct: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAK---KPEEESESSE-EGSESEEEAPAGTRSQ-- 290
Query: 869 AETQLETTQAGEKIQEDRKAQAD-KGTQEDRRMQGEKGMQGEKGTQ---------SEGSA 918
+A EKI + R A A KGT G G +Q SE S+
Sbjct: 291 -------VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSS 343
Query: 919 PTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCL-PRS 977
+ + + E A +L + K AP ++P P PG P
Sbjct: 344 EESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK-----ESPRKGAAPAPPGKTGPAV 398
Query: 978 EEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVG------------GERCRGPQS 1025
+A Q+ PAQ G QV G P+
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 1026 SGPVEA-----KQEDSPFQCPKEERPG--GVPCMDQGGCPLAGLSQEVPTMPSL------ 1072
+GP A KQE+ +E + M+ G S +V ++
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 1073 PGTGLTASPKAGPCSTPTSQHG---------STATFLPSEDQVLMSSAPTLHLGLGTPTQ 1123
G G K GP +TP++Q G S + S+ +V + AP LG Q
Sbjct: 519 KGAGPVPPGKVGP-ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577
Query: 1124 SHPPETMATSSEGACAQVP-DVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGG 1182
+ P + A V V+ P S SS E+S +
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS------------------ESSEESSDSAD 619
Query: 1183 ESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRL 1242
+ AA + +A P +++ P+T P +
Sbjct: 620 SEEAPAA----MTAAQAKPALKI----PQTKA--------------------CPKKTNTT 651
Query: 1243 TGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGE-------- 1294
V+ G QA A + P SS PA+ + P S + E +
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSS---PAVAGGTQRPAEDSSSSEESDSEEEKTGL 708
Query: 1295 ----GEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQ-GPSAESI-AQEPSQEEKFPGE 1348
G+ G GL + + G LG+ PG+ GP+ + A++ E E
Sbjct: 709 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 768
Query: 1349 ALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPG 1408
+ + AA+P ++ ++ + AA A V+ K P
Sbjct: 769 SDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
Query: 1409 TPGRERRSPTQGRK--ASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAK 1465
P R ++ T + AS+ V +A A GP +G + E +E + ETLA+
Sbjct: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE-EAETLAQ 886
Score = 48.5 bits (114), Expect = 6e-05
Identities = 228/1123 (20%), Positives = 378/1123 (33%), Gaps = 203/1123 (18%)
Query: 385 AKLKRKAAAKLREIEQSWKHEKAVPGEVD--TLRKLSPDRFQRKRRLSGAQAPGPSVPTR 442
+ +K KA A E E++ K ++P T+ L + RK S + ++ +
Sbjct: 119 SSMKEKAKA---ETEKAGKTGNSMPHPATGKTVANLLSGKSPRK---SAEPSANTTLVSE 172
Query: 443 EPEGGTL----AAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYI 498
E G++ AA + G Q S +S E G+ + + + + T
Sbjct: 173 TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232
Query: 499 CDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCG 558
A + P + + K + +KPE E++ S SE S+E G
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE-EESESSEEGSE-----SEEEAPAG 286
Query: 559 TQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLK 618
T+ V + Q R +A G+ G +T P G KA P E
Sbjct: 287 TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346
Query: 619 DMYLENTQAVRPLGEEGPQTLSVRAPGE-SPKGKAPLRARSEGVPGAPGQPTHSLTPQPT 677
E T A + L L +A G+ S G A A+ GA P P T
Sbjct: 347 SDSEEETPAAKAL-------LQAKASGKTSQVGAASAPAKESPRKGAAPAP-----PGKT 394
Query: 678 RPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGT 737
P K A K + ++ + S+ S +AP A+ GKAP + P
Sbjct: 395 GPAVAKAQA-GKREEDSQSSSEESDSEEEAP-AQAKPSGKAPQVRAASAP---------A 443
Query: 738 RDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQED 797
++S +G A AP ++ +G + +ED
Sbjct: 444 KESPRKGAA--------------PAPPRKTGPAAAQVQVG---------------KQEED 474
Query: 798 GRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDR 857
R+S+ + ++ + A QV K PQ
Sbjct: 475 SRSSSEESDSDREALAAMNAAQV--------------------------KPLGKSPQVKP 508
Query: 858 SAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGS 917
++ GM G+ + + G AQ K +ED E E S+G
Sbjct: 509 ASTMGMGPLGKGAGPVPPGKVGPATP---SAQVGK-WEEDSESSSE-----ESSDSSDGE 559
Query: 918 APTAMEGQSEQEVATSL--GPPSRTPKLPP-TAGPRA-------PL-NIECFVQTPEGSC 966
PTA+ E+ + L P S K PP AGP A P+ N E ++ + +
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSAD 619
Query: 967 FPKKPGCLPRSE---------------EAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGS 1011
+ P + ++ + TAS +G + A P S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679
Query: 1012 VEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPS 1071
GG + SS E+ E EE+ G + Q GL + ++P
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSE--------EEKTGLAVTVGQAKSVGKGLQVKAASVPV 731
Query: 1072 LPGTGLTASP----KAGPCSTPT---SQHGSTATFLPSEDQVLMSSAPTLHLGL-GTPTQ 1123
G +P K GP T Q S ++ S+ + +S + + T +
Sbjct: 732 KGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 1124 SHPPETMATSSEGACAQVPDV-----EGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETS 1178
++P A S++G + V + + P P + + +N +L +S +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSV 850
Query: 1179 GAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCT 1238
G + A TG E +G S E + + A+TL
Sbjct: 851 GKAVATAAQAQTG----------PEEDSGSSE----------EESDSEEEAETL-----A 885
Query: 1239 SRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVP--AIVVDEEDPGLASEGA-SEGEG 1295
+ +G + A A + R P P T P A ++D G +SE + S+GE
Sbjct: 886 QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEA 945
Query: 1296 EVSPEG-----PGLLGASQESSMAGRL---GEAGGQAAPGQGPSAESIAQ----EPSQEE 1343
+ P L+ S AG +A + P + ++ES A+ E E+
Sbjct: 946 PAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDED 1005
Query: 1344 KFPG-EALTGLPAATPEELALGARRKRFLPKVRAAG------DGEATTPEERESPTVSPR 1396
P + LT P + + R PK AG + +++E P
Sbjct: 1006 VIPATQCLT--PGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063
Query: 1397 GPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGD 1439
+L SP + + + + RK + EV +A + + D
Sbjct: 1064 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSD 1106
Score = 45.8 bits (107), Expect = 4e-04
Identities = 88/409 (21%), Positives = 153/409 (37%), Gaps = 69/409 (16%)
Query: 529 LRKPELEKAAQSRRSSENCIPSSDEPDSCG-----TQGPVGVEQVQTQPRGRAARGPGSS 583
LRKP+L + Q+ ++ E+ S D DS +GP G + T GP S
Sbjct: 1087 LRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT-------LGPTPS 1139
Query: 584 GTDSTRKPASAVGTPDKAQKAPGPGPGQEVY--FSLKDMYLENTQAVR--PLGEEGPQTL 639
T++ + +A + D P Q + + + N+QA + P + P
Sbjct: 1140 RTETLVEETAAESSEDDV-----VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1194
Query: 640 SVRAPGESPKGK---APLRARSEGVPGAPGQPTHS-LTPQPTRPFNRKRFAPPKPKGEAT 695
S A + P GK P +A P G+ S TPQ +R PK KG
Sbjct: 1195 STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSR--------KPK-KGAGN 1245
Query: 696 TDSKPISSLSQAPEC---GAQSLGKAPPQAS-VQVPTPPARRRH-----GTRDSTLQGQA 746
+ ++ S +C L +A QAS V+V T + T++S+ +G
Sbjct: 1246 PQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWE 1305
Query: 747 GHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRT 806
+ + P S +G G + + P T G+ ++ +
Sbjct: 1306 SRKRK------LSGDQPAARTPRSKKKKKLGAG-EGGEASVSPEKTSTTSKGKAKRDKAS 1358
Query: 807 GSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQ 866
G K + G + G+Q A + + + Q GT E D+S K
Sbjct: 1359 GDVKEKKGKGSL---------GSQGA-KDEPEEELQKGMGTVEG----GDQSNPK----- 1399
Query: 867 GRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSE 915
+ E + + +K ++++K +A K + +D +K + +K T +
Sbjct: 1400 SKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1448
Score = 34.7 bits (78), Expect = 0.92
Identities = 102/482 (21%), Positives = 163/482 (33%), Gaps = 72/482 (14%)
Query: 410 GEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLIN 469
G + K+ Q K+R P P R P+ T+ A + + +
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKP----PVRNPQNSTVLARGPASVPSVGKA-VATAA 858
Query: 470 SFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGL 529
+G +G + E+ + E L + + + RA + +K + G
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 530 RKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTR 589
P +A + S SS+E DS G + P V Q P D R
Sbjct: 919 TGPSAAQAGKQDDSGS----SSEESDSDG-EAPAAVTSAQVIK-------PPLIFVDPNR 966
Query: 590 KPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLEN--------TQAVRPLGEEGPQTLSV 641
PA TP +AQ A P + + + E+ TQ + P G +T V
Sbjct: 967 SPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP----GIRTNVV 1022
Query: 642 RAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPI 701
P P+ A + GA S + + +R + K+ P + ++ + P
Sbjct: 1023 TMPTAHPR-----IAPKASMAGA------SSSKESSRISDGKKQEGPATQVDSAVGTLPA 1071
Query: 702 SSLSQAPECGAQSLGK--APPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGE------ 753
+S Q+ A+ K P VQ T + DS+ +G GE
Sbjct: 1072 TS-PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS-DSSSGSEEDGEGPQGAK 1129
Query: 754 ------VLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTG 807
+T T +A+ SS+ + S S G + P G T AN +
Sbjct: 1130 SAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP--------GLTPANSQ-A 1180
Query: 808 SKKNVQADGKIQVD----GRTRGDGTQTAQRTRADRKTQVDAGTQES---KRPQSDRSAQ 860
SK + D V + DG Q A+ +A G +E+ PQ R +
Sbjct: 1181 SKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1240
Query: 861 KG 862
KG
Sbjct: 1241 KG 1242
Score = 33.9 bits (76), Expect = 1.6
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 412 VDTLRKLSPDRFQ-RKRRLSGAQAPGPSVPTREPEGGTLAAWQEGET-----ETAQHSGL 465
VDT ++ S ++ RKR+LSG Q P P R + L A + GE +T+ S
Sbjct: 1293 VDTTKESSRKGWESRKRKLSGDQ-PAARTP-RSKKKKKLGAGEGGEASVSPEKTSTTSKG 1350
Query: 466 GLINSFASGEVTTN---GEAAPENGEDGEHGLLTYICDAMELGPQ---RALKEESGAKKK 519
ASG+V G + +D L +E G Q ++ KE+ + K+
Sbjct: 1351 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1410
Query: 520 KKDEESKQGLRKPELEKAAQSRRSSE 545
KKD+E K+ +K + S S+
Sbjct: 1411 KKDKEKKEKKKKAKKASTKDSESPSQ 1436
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 61.6 bits (148), Expect = 7e-09
Identities = 168/786 (21%), Positives = 261/786 (33%), Gaps = 141/786 (17%)
Query: 753 EVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNV 812
E E +T A AS++S V + P M+ + T +TG+
Sbjct: 92 EEAEAETAKATPRLASTNSSVLGADL----------PSSMKEKAKAETEKAGKTGNSMPH 141
Query: 813 QADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQ 872
A GK V G + + A+ T V +E P +A+ GM++ G+A++
Sbjct: 142 PATGKT-VANLLSGKSPRKSAEPSANT-TLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 873 LETT-----------QAGEKIQEDRKAQAD-KGTQEDRRMQGEKGMQGEKGTQ------- 913
E T +A EKI + R A A KGT G G +Q
Sbjct: 200 SEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE 259
Query: 914 --SEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKP 971
SE S+ + + + E A +L + K AP ++P P P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK-----ESPRKGAAPAPP 314
Query: 972 GCL-PRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQV------------GGE 1018
G P +A Q+ PAQ G QV G
Sbjct: 315 GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA 374
Query: 1019 RCRGPQSSGPVEA-----KQEDSPFQCPKEERPG--GVPCMDQGGCPLAGLSQEV---PT 1068
P+ +GP A KQE+ +E + M+ G S +V T
Sbjct: 375 APAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 434
Query: 1069 M---PSLPGTGLTASPKAGPCSTPTSQHG---------STATFLPSEDQVLMSSAPTLHL 1116
M P G G K GP +TP++Q G S + S+ +V + AP
Sbjct: 435 MGMGPLGKGAGPVPPGKVGP-ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 493
Query: 1117 GLGTPTQSHPPETMATSSEGACAQVP-DVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSST 1175
LG Q+ P + A V V+ P S SS
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS------------------ESSE 535
Query: 1176 ETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLS 1235
E+S + + AA + +A P +++ P+T
Sbjct: 536 ESSDSADSEEAPAA----MTAAQAKPALKI----PQTK--------------------AC 567
Query: 1236 PCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGE- 1294
P + V+ G QA A + P SS PA+ + P S + E +
Sbjct: 568 PKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS---PAVAGGTQRPAEDSSSSEESDS 624
Query: 1295 -----------GEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQ-GPSAESI-AQEPSQ 1341
G+ G GL + + G LG+ PG+ GP+ + A++
Sbjct: 625 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 684
Query: 1342 EEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKS 1401
E E+ + AA+P ++ ++ + AA A V+ K
Sbjct: 685 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 744
Query: 1402 LVPGSPGTPGRERRSPTQGRK--ASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGK 1459
P P R ++ T + AS+ V +A A GP +G + E +E +
Sbjct: 745 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE-E 803
Query: 1460 QETLAK 1465
ETLA+
Sbjct: 804 AETLAQ 809
Score = 58.5 bits (140), Expect = 6e-08
Identities = 107/546 (19%), Positives = 186/546 (34%), Gaps = 65/546 (11%)
Query: 538 AQSRRSSENCIPSSDEPDSCGTQGPV--GVEQVQTQPRGRAARGPGSSGTDSTRKPASAV 595
A+ + SE+ SD ++ + V V++ Q + AAR P + GT S
Sbjct: 679 AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS-------- 730
Query: 596 GTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPK-GKAPL 654
PG+ V + + ++ P+ T+ R P P GKA
Sbjct: 731 ------------APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV- 777
Query: 655 RARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQS 714
A + P + + S + + A KP G+ ++ ++P GA
Sbjct: 778 -ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP 836
Query: 715 L--GKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSD 772
GK P A+ A ++ + S+ + + P V Q P + +
Sbjct: 837 TPPGKTGPSAA------QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRS 890
Query: 773 VASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTA 832
A + + +Q P E S++ + + + A + RT TA
Sbjct: 891 PAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTA 950
Query: 833 QRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQ--GRAETQLETTQAGEKIQEDRKAQA 890
A + + A + + SD Q+G TQ + L TQA K+ + ++A
Sbjct: 951 HPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA 1010
Query: 891 DKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPT-AGP 949
R Q G+ GT T+ + S Q T+ R PKLP
Sbjct: 1011 QPPV---ARTQPSSGVDSAVGT----LPATSPQSTSVQAKGTN---KLRKPKLPEVQQAT 1060
Query: 950 RAPLNIECFVQTPEGSCFPKKPGCLPRSEEAV----------------VTASRNHEQTVL 993
+AP + + + + S ++ G P+ ++ TA+ + E V+
Sbjct: 1061 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVV 1120
Query: 994 GP---LSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVP 1050
P L M P P + + P S + AK + Q K ++ G+
Sbjct: 1121 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1180
Query: 1051 CMDQGG 1056
GG
Sbjct: 1181 SPKTGG 1186
Score = 51.2 bits (121), Expect = 9e-06
Identities = 211/1007 (20%), Positives = 337/1007 (33%), Gaps = 189/1007 (18%)
Query: 531 KPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRK 590
KP + A Q+ SSE+ SSDE D V + Q R +A G+ G +T
Sbjct: 187 KPGMVSAGQADSSSEDTSSSSDETDV-----EVKASEKILQVRAASAPAKGTPGKGATPA 241
Query: 591 PASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGE-SPK 649
P G KA P E E T A + L L +A G+ S
Sbjct: 242 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL-------LQAKASGKTSQV 294
Query: 650 GKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPE 709
G A A+ GA P P T P K A K + ++ + S+ S +AP
Sbjct: 295 GAASAPAKESPRKGAAPAP-----PGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAP- 347
Query: 710 CGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASS 769
A+ GKAP + P ++S +G A AP
Sbjct: 348 AQAKPSGKAPQVRAASAP---------AKESPRKGAA--------------PAPPRKTGP 384
Query: 770 SSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGT 829
++ +G + +ED R+S+ + ++ + A QV
Sbjct: 385 AAAQVQVG---------------KQEEDSRSSSEESDSDREALAAMNAAQV--------- 420
Query: 830 QTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQ 889
K PQ ++ GM G+ + + G AQ
Sbjct: 421 -----------------KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATP---SAQ 460
Query: 890 ADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSL--GPPSRTPKLPP-T 946
K +ED E E S+G PTA+ E+ + L P S K PP
Sbjct: 461 VGK-WEEDSESSSE-----ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 514
Query: 947 AGPRA-------PL-NIECFVQTPEGSCFPKKPGCLPRSE---------------EAVVT 983
AGP A P+ N E ++ + + + P + ++ + T
Sbjct: 515 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 984 ASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKE 1043
AS +G + A P S GG + SS E+ E E
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSE--------E 626
Query: 1044 ERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASP----KAGPCSTPT---SQHGST 1096
E+ G + Q GL + ++P G +P K GP T Q S
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 1097 ATFLPSEDQVLMSSAPTLHLGL-GTPTQSHPPETMATSSEGACAQVPDV-----EGRTPG 1150
++ S+ + +S + + T +++P A S++G + V + +
Sbjct: 687 SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 746
Query: 1151 PRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSP 1210
P P + + +N +L +S + G + A TG E +G S
Sbjct: 747 PSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQAQTG----------PEEDSGSSE 795
Query: 1211 RTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSS 1270
E + + A+TL + +G + A A + R P P
Sbjct: 796 ----------EESDSEEEAETL-----AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPG 840
Query: 1271 LTVP--AIVVDEEDPGLASEGA-SEGEGEVSPEG-----PGLLGASQESSMAGRL---GE 1319
T P A ++D G +SE + S+GE + P L+ S AG +
Sbjct: 841 KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ 900
Query: 1320 AGGQAAPGQGPSAESIAQ----EPSQEEKFPG-EALTGLPAATPEELALGARRKRFLPKV 1374
A + P + ++ES A+ E E+ P + LT P + + R PK
Sbjct: 901 AQAASTPRKARASESTARSSSSESEDEDVIPATQCLT--PGIRTNVVTMPTAHPRIAPKA 958
Query: 1375 RAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGT-PGRERRSPTQGRKASMLEVPRAEE 1433
AG ++ R S GP + +P + P + +KAS + P A
Sbjct: 959 SMAG-ASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVART 1017
Query: 1434 ELAAG---DLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQ 1477
+ ++G +G P T V + K + + KAP+
Sbjct: 1018 QPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPE 1064
Score = 45.8 bits (107), Expect = 4e-04
Identities = 97/454 (21%), Positives = 164/454 (36%), Gaps = 84/454 (18%)
Query: 484 PENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRS 543
P +G D G L PQ + G K LRKP+L + Q+ ++
Sbjct: 1019 PSSGVDSAVGTLP------ATSPQSTSVQAKGTNK----------LRKPKLPEVQQATKA 1062
Query: 544 SENCIPSSDEPDSCG-----TQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTP 598
E+ S D DS +GP G + T GP S T++ + +A +
Sbjct: 1063 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT------LVGPTPSRTETLVEETAAESSE 1116
Query: 599 DKAQKAPGPGPGQEVY--FSLKDMYLENTQAVR--PLGEEGPQTLSVRAPGESPKGK--- 651
D P Q + + + N+QA + P + P S A + P GK
Sbjct: 1117 DDV-----VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEA 1171
Query: 652 APLRARSEGVPGAPGQPTHS-LTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPEC 710
P +A P G+ S TPQ +R PK KG + ++ S +C
Sbjct: 1172 KPQQAAGMLSPKTGGKEAASGTTPQKSR--------KPK-KGAGNPQASTLALQSNITQC 1222
Query: 711 ---GAQSLGKAPPQAS-VQVPTPPARRRH-----GTRDSTLQGQAGHRTPGEVLECQTTT 761
L +A QAS V+V T + T++S+ +G + +
Sbjct: 1223 LLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGD 1276
Query: 762 APTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVD 821
P S +G G + + P T G+ ++ +G K + G +
Sbjct: 1277 QPAARTPRSKKKKKLGAG-EGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSL--- 1332
Query: 822 GRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEK 881
G+Q A + + + Q GT E D+S K + E + + +K
Sbjct: 1333 ------GSQGA-KDEPEEELQKGMGTVEG----GDQSNPK-----SKKEKKKSDKRKKDK 1376
Query: 882 IQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSE 915
++++K +A K + +D +K + +K T +
Sbjct: 1377 EKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1410
Score = 33.9 bits (76), Expect = 1.6
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 412 VDTLRKLSPDRFQ-RKRRLSGAQAPGPSVPTREPEGGTLAAWQEGET-----ETAQHSGL 465
VDT ++ S ++ RKR+LSG Q P P R + L A + GE +T+ S
Sbjct: 1255 VDTTKESSRKGWESRKRKLSGDQ-PAARTP-RSKKKKKLGAGEGGEASVSPEKTSTTSKG 1312
Query: 466 GLINSFASGEVTTN---GEAAPENGEDGEHGLLTYICDAMELGPQ---RALKEESGAKKK 519
ASG+V G + +D L +E G Q ++ KE+ + K+
Sbjct: 1313 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1372
Query: 520 KKDEESKQGLRKPELEKAAQSRRSSE 545
KKD+E K+ +K + S S+
Sbjct: 1373 KKDKEKKEKKKKAKKASTKDSESPSQ 1398
>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
Length = 1499
Score = 61.2 bits (147), Expect = 9e-09
Identities = 240/999 (24%), Positives = 305/999 (30%), Gaps = 210/999 (21%)
Query: 558 GTQGPVGVEQVQTQPRGRAA-RGPGSSGTDSTRKPASAVGTPDKAQKAPGPGP-GQEVYF 615
G+QGP G + P+GR RGP G D G P PGP G F
Sbjct: 138 GSQGPRG----ERGPKGRPGPRGP--QGIDGEPGVPGQPGAPGPPGHPSHPGPDGLSRPF 191
Query: 616 SLKDMYLENTQ-----------AVRPLGEEGPQTLSVRAPGESPKGK----------APL 654
S + L+ +V P+G GPQ L + G P G P+
Sbjct: 192 SAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPI 251
Query: 655 RARS-EGVPGAPGQ---PTHSLTPQ-------------------PTRPFNRKRFAPPKPK 691
+R EG PG PG+ P + P P +R PK
Sbjct: 252 GSRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPK 311
Query: 692 GEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAG-HRT 750
GE P S P ++G P+ P R R G + + GQ G H
Sbjct: 312 GEV---GAPGSKGEAGPTGPMGAMGPLGPRGM-----PGERGRLGPQGAP--GQRGAHGM 361
Query: 751 PGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKK 810
PG+ P S + +G++G P + E G G
Sbjct: 362 PGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGARGPEGPQG-QRGETGPPGPVGSPGLPG 420
Query: 811 NVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQG-RA 869
+ DG G T GT + + G Q S PQ R G +
Sbjct: 421 AIGTDGTPGAKGPTGSPGTSGPPGSAGPPGSP---GPQGSTGPQGIRGQPGDPGVPGFKG 477
Query: 870 ETQLETTQAGEKIQED---------RKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPT 920
E + IQ R + D GT GE+G G +G P
Sbjct: 478 EAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPG 537
Query: 921 AMEGQSEQEVATSLGP------PSRTPKLPPTAGPRAPLNIECFVQTPEGSCFP-KKPG- 972
Q E+ S GP P R P P G R L VQ PEG P PG
Sbjct: 538 PKGAQGERGPVGSSGPKGSQGDPGR-PGEPGLPGARG-LTGNPGVQGPEGKLGPLGAPGE 595
Query: 973 -CLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQS----SG 1027
P ++ + + GP G+ P +P G+ G G SG
Sbjct: 596 DGRPGPPGSIGIRGQPGSMGLPGP-KGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSG 654
Query: 1028 PV-------EAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTAS 1080
PV E ++ P + PG +GG P Q VP P G
Sbjct: 655 PVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKP---GDQGVPGDPGAVG---PLG 708
Query: 1081 PKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLG----LGTPTQSHPPETMATSSEG 1136
P+ G P + T LP E + P G GTP + PP E
Sbjct: 709 PR-GERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGER 767
Query: 1137 ACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPS 1196
A TPGP+ G + G G G L P
Sbjct: 768 GIA-------GTPGPKGDRGG--------------IGEKGAEGTAGNDGARGLPGPLGPP 806
Query: 1197 ATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQA 1256
PT E PR L+ P SR G G
Sbjct: 807 GPAGPTGEKGEPGPRG--------------------LVGPPGSRGNPG------SRGENG 840
Query: 1257 LAAARGSWGP-GPSSLTVPAIVVDEEDPGLASEGASEG----EGEVSPEGP--------- 1302
A G GP GP P + + +PG + S G G P GP
Sbjct: 841 PTGAVGFAGPQGPDG--QPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGG 898
Query: 1303 ----GLLGASQESSMAGRLGEAGGQAAPG-QGPSAESIAQEPSQEEKFPGEALTGLPAAT 1357
G GA+ AGR+G G APG GP E + P PG L G P +
Sbjct: 899 RGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGP------PG--LRGDPGSH 950
Query: 1358 PEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRER--R 1415
+G R P G G+ P E P P GP PG GT G+
Sbjct: 951 GR---VGDRG----PAGPPGGPGDKGDPGEDGQP--GPDGP-----PGPAGTTGQRGIVG 996
Query: 1416 SPTQGRKASMLEVP-------RAEEELAAGDLGPSPKAG 1447
P Q + M +P + A GD GP G
Sbjct: 997 MPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVG 1035
Score = 48.1 bits (113), Expect = 8e-05
Identities = 194/843 (23%), Positives = 248/843 (29%), Gaps = 219/843 (25%)
Query: 630 PLGEEGPQTLSVRAPGESPKGKAPLRARSE----GVPGAPGQPTHSLTPQP---TRPFNR 682
P G +GP+ R P P + P E G PGAPG P H P P +RPF
Sbjct: 136 PPGSQGPR--GERGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGLSRPF-- 191
Query: 683 KRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTL 742
S ++ L + G+Q +G P P P L
Sbjct: 192 ---------------SAQMAGLDEKSGLGSQ-VGLMPGSVGPVGPRGP---------QGL 226
Query: 743 QGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSA 802
QGQ G P T P + IG + G +G + EDG
Sbjct: 227 QGQQGGAGP---------TGPPGEPGDPGPMGPIG--SRGPEG----PPGKPGEDGEPGR 271
Query: 803 NQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKG 862
N G + G G G + + + + + G SK
Sbjct: 272 NGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGA 331
Query: 863 MMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAM 922
M G R M GE+G G +G + A
Sbjct: 332 M-----------------------------GPLGPRGMPGERGRLGPQGAPGQRGA---- 358
Query: 923 EGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVV 982
+P GP PL I P S FP PG EA
Sbjct: 359 ------------------HGMPGKPGPMGPLGI------PGSSGFPGNPG---MKGEAGP 391
Query: 983 TASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRG-PQSSGPVEAKQEDSPFQCP 1041
T +R E GP G P GS G G P + GP + P P
Sbjct: 392 TGARGPE----GP-QGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGTSGP---P 443
Query: 1042 KEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLP 1101
P G P QG G+ + P P +PG A PK P HG P
Sbjct: 444 GSAGPPGSP-GPQGSTGPQGIRGQ-PGDPGVPGFKGEAGPKGEP-----GPHGIQGPIGP 496
Query: 1102 SEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSC--DPGLI 1159
++ G P PP + P +G PGP+ + G +
Sbjct: 497 PGEEGKRGPR-------GDPGTVGPPGPVGERGAPGNRGFPGSDG-LPGPKGAQGERGPV 548
Query: 1160 DSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILER 1219
S S G GE + A G
Sbjct: 549 GSSG-------PKGSQGDPGRPGEPGLPGARG---------------------------- 573
Query: 1220 VENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWG-PGPSSLTVPAIVV 1278
+ N VQ + L G L + GR + G G PG S+ +P
Sbjct: 574 LTGNPGVQGPEGKL----------GPLGAPGEDGRPGPPGSIGIRGQPG--SMGLPGPKG 621
Query: 1279 DEEDPGLASEGASEG----------EGEVSPEGP-GLLGASQESSMAGRLGEAGGQAAPG 1327
DPG E + G +GEV P GP G G + E G G G Q PG
Sbjct: 622 SSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPG 681
Query: 1328 -QGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPE 1386
GP P + K + + G P A LG R +R P R E
Sbjct: 682 PPGP--------PGEGGKPGDQGVPGDPGAVG---PLGPRGERGNPGERGEPGITGLPGE 730
Query: 1387 ERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKA 1446
+ + P GP+ S PG GTPG QG E AG GP
Sbjct: 731 KGMAGGHGPDGPKGS--PGPSGTPGDTGPPGLQGMPG---------ERGIAGTPGPKGDR 779
Query: 1447 GGL 1449
GG+
Sbjct: 780 GGI 782
Score = 45.8 bits (107), Expect = 4e-04
Identities = 106/437 (24%), Positives = 134/437 (30%), Gaps = 100/437 (22%)
Query: 553 EPDSCGTQGPVGVEQVQTQPRGRAARG-PGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQ 611
EP G G G + + P G PG G T+ P A G P A + PGP
Sbjct: 865 EPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAG 924
Query: 612 EVYFSLKDMYLENTQAVRPLGE---EGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQP 668
PLGE EGP L PG + A G PG G P
Sbjct: 925 A------------PGPAGPLGEPGKEGPPGLR-GDPGSHGRVGDRGPAGPPGGPGDKGDP 971
Query: 669 THSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPT 728
P P PP P G TT + I V
Sbjct: 972 GEDGQPGPD--------GPPGPAG--TTGQRGI------------------------VGM 997
Query: 729 PPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIE 788
P R G L G AG TPG+V PT + +G GS G +
Sbjct: 998 PGQRGERGMPG--LPGPAG--TPGKV-------GPTGATGDKGPPGPVG--PPGSNGPVG 1044
Query: 789 PMDME--TQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAG 846
E DG + G + + G + G GT D + D G
Sbjct: 1045 EPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPG 1104
Query: 847 TQESKRPQSDRSAQKGMM-TQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKG 905
++ P R+ ++G+ QG + DKG DR +G+KG
Sbjct: 1105 SRGPIGPPG-RAGKRGLPGPQG--------------------PRGDKGDHGDRGDRGQKG 1143
Query: 906 MQGEKGTQSEGSAPTAMEGQSEQEVATSLGP--------PSRTPKLPPTAGPRAPLNIEC 957
+G G Q P Q + GP PS P GP P +
Sbjct: 1144 HRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRG 1203
Query: 958 FV--QTPEGSCFPKKPG 972
V PEG P +PG
Sbjct: 1204 SVGEAGPEGP--PGEPG 1218
Score = 38.5 bits (88), Expect = 0.063
Identities = 59/230 (25%), Positives = 79/230 (34%), Gaps = 32/230 (13%)
Query: 14 PLARQGEGQSRLVPGRGLVLWLPGLPRSS--PSWPAV--DLAPLAPARPRGPLICHTGHE 69
P G+ + +PG+ + G+P SS P P + + P P GP G
Sbjct: 349 PQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGARGPEGP----QGQR 404
Query: 70 QAGREPGPGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWA 129
PGP S P PG + T +G GS +GP
Sbjct: 405 GETGPPGPVGS----------------PGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAGP 448
Query: 130 PAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEA 189
P PG P R G V + A +G P +GP G+
Sbjct: 449 PGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPH-----GIQGPIGPPGEEGKR 503
Query: 190 AASAGP-AVGEGGAMGSRRAP-SRGW-GAGGRSGAGGDGEDDGPVWIPSP 236
P VG G +G R AP +RG+ G+ G G G + GPV P
Sbjct: 504 GPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGP 553
Score = 37.4 bits (85), Expect = 0.14
Identities = 70/252 (27%), Positives = 92/252 (36%), Gaps = 47/252 (18%)
Query: 14 PLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPARPRGPLICHTGHEQAGR 73
P+ +G +R PG GLP P + P+ + P+G G
Sbjct: 517 PVGERGAPGNRGFPGSD------GLP--GPKGAQGERGPVGSSGPKGS----QGDPGRPG 564
Query: 74 EPG-PGSS--TKGPVLHDQDTRCAFL--------PRPPGPLQTRRYCRHQGRQGSGLGAG 122
EPG PG+ T P + + + L P PPG + R G+ GS G
Sbjct: 565 EPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIR------GQPGSMGLPG 618
Query: 123 PGAGTWAPAPPG-VSKPRCPG-RARPGEGQQQVTTAR--PPAI--NRGARQPRAGAAAAG 176
P + P PG PG R PG+ + + PP + RG + P G
Sbjct: 619 PKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQG 678
Query: 177 R----GPGAGAWRTGEAAASAGP-AVGEGGAMGSRRAPS-RG----WGAGGRSG-AGGDG 225
GP + G+ P AVG G G R P RG G G G AGG G
Sbjct: 679 LPGPPGPPGEGGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHG 738
Query: 226 EDDGPVWIPSPA 237
DGP P P+
Sbjct: 739 -PDGPKGSPGPS 749
Score = 37.4 bits (85), Expect = 0.14
Identities = 53/202 (26%), Positives = 72/202 (35%), Gaps = 25/202 (12%)
Query: 1266 PGPSSLTVPAIVVDEED----PGLASEGASEGE-GEVSPEGPGLLGASQESSMAGRLGEA 1320
PGP+ PA + E PGL + S G G+ P GP G + G G+
Sbjct: 920 PGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPP--GGPGDKGDPGEDGQP 977
Query: 1321 GGQAAPGQGPSA--ESIAQEPSQEEKFPGEALTGLPAATPEELA-LGARRKRFLP-KVRA 1376
G PG + I P Q + L G PA TP ++ GA + P V
Sbjct: 978 GPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPG-PAGTPGKVGPTGATGDKGPPGPVGP 1036
Query: 1377 AGDGEATTPEERESPT-----------VSPRGPRKSLVPGSPGTPGRERRSPTQGRKASM 1425
G E P V RG R PG G PG + T G +
Sbjct: 1037 PGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGD--PGPAGLPGSQGAPGTPGPVGAP 1094
Query: 1426 LEVPRAEEELAAGDLGPSPKAG 1447
+ + + + G +GP +AG
Sbjct: 1095 GDAGQRGDPGSRGPIGPPGRAG 1116
Score = 36.2 bits (82), Expect = 0.31
Identities = 61/221 (27%), Positives = 74/221 (33%), Gaps = 31/221 (14%)
Query: 36 PGLPRSSPSWPAVDLAPLAPARPRGPLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAF 95
P P+ P V P AP P P H G + R P ++
Sbjct: 154 PRGPQGIDGEPGVPGQPGAPGPPGHP--SHPGPDGLSR-PFSAQMAGLDEKSGLGSQVGL 210
Query: 96 LPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKP---RCP--GRARPGEGQ 150
+P GP+ R QG QG GAGP P PG P R P +PGE
Sbjct: 211 MPGSVGPVGPRG---PQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDG 267
Query: 151 QQVTTARPPAINRGARQPRAGAAAAGRGPGAGAWR--------TGEAAA-----SAGPA- 196
+ P + G A PG R GE A AGP
Sbjct: 268 EPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTG 327
Query: 197 -VGEGGAMGSRRAP-SRG----WGAGGRSGAGGDGEDDGPV 231
+G G +G R P RG GA G+ GA G GP+
Sbjct: 328 PMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPM 368
Score = 35.8 bits (81), Expect = 0.41
Identities = 45/152 (29%), Positives = 57/152 (37%), Gaps = 16/152 (10%)
Query: 99 PPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGE-GQQQVTTAR 157
PPGP+ R ++G GS GP P G S P+ + PG G+ + AR
Sbjct: 514 PPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPK-GSQGDPGRPGEPGLPGAR 572
Query: 158 PPAINRGARQPRAGAAAAGR-------GPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPS 210
N G + P G GP G+ + P G G+ G P
Sbjct: 573 GLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLP--GPKGSSGDPGKPG 630
Query: 211 RGWGAG--GRSGA-GGDGE--DDGPVWIPSPA 237
AG G+ GA G DGE GPV P A
Sbjct: 631 EAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLA 662
Score = 35.0 bits (79), Expect = 0.70
Identities = 41/143 (28%), Positives = 46/143 (32%), Gaps = 21/143 (14%)
Query: 96 LPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPG--RARPGEGQQQV 153
LP PPGP G G PG P PG P P R PGE +
Sbjct: 679 LPGPPGP--------------PGEGGKPG-DQGVPGDPGAVGPLGPRGERGNPGERGEPG 723
Query: 154 TTARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGW 213
T P G + GP TG P GE G G+ P
Sbjct: 724 ITGLPGEKGMAGGHGPDGPKGSP-GPSGTPGDTGPPGLQGMP--GERGIAGTP-GPKGDR 779
Query: 214 GAGGRSGAGGDGEDDGPVWIPSP 236
G G GA G +DG +P P
Sbjct: 780 GGIGEKGAEGTAGNDGARGLPGP 802
Score = 34.3 bits (77), Expect = 1.2
Identities = 36/128 (28%), Positives = 45/128 (35%), Gaps = 13/128 (10%)
Query: 113 GRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGA 172
G +G G GP +P P G P + G++ + P +RG +
Sbjct: 729 GEKGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAE 788
Query: 173 AAAGR----------GPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAG 222
AG GP A TGE GP G G GSR P G G +GA
Sbjct: 789 GTAGNDGARGLPGPLGPPGPAGPTGE-KGEPGPR-GLVGPPGSRGNPG-SRGENGPTGAV 845
Query: 223 GDGEDDGP 230
G GP
Sbjct: 846 GFAGPQGP 853
Score = 33.9 bits (76), Expect = 1.6
Identities = 58/223 (26%), Positives = 77/223 (34%), Gaps = 26/223 (11%)
Query: 1242 LTGLLDREVQAGRQALAAARGSWGP-------GPSSLTVPAIVVDEEDPGLASE-GASEG 1293
+TG+ R AG RG GP GP + + +PG+ + GA
Sbjct: 124 VTGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGI--------DGEPGVPGQPGAPGP 175
Query: 1294 EGEVSPEGPGLLGASQESSMAGR-----LGEAGGQAAPGQGPSAESIAQEPSQEEKFPGE 1348
G S GP L + MAG LG G GP Q ++ G
Sbjct: 176 PGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQG--GA 233
Query: 1349 ALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESP-TVSPRG-PRKSLVPGS 1406
TG P + +G R P+ GE P +P V G P PG+
Sbjct: 234 GPTGPPGEPGDPGPMGPIGSRG-PEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGFPGA 292
Query: 1407 PGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGL 1449
PG PG + +G + EV + AG GP G L
Sbjct: 293 PGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPL 335
Score = 33.1 bits (74), Expect = 2.7
Identities = 51/195 (26%), Positives = 59/195 (30%), Gaps = 19/195 (9%)
Query: 52 PLAPARPRGPLICHTGHEQAGREPGP--------GSSTKGPVLHDQDTRCAFLPRPPGPL 103
PL P P GP TG + EPGP G + T P GP
Sbjct: 802 PLGPPGPAGP----TGEKG---EPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPD 854
Query: 104 QTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINR 163
G G AG PG P + G G Q A +
Sbjct: 855 GQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSA 914
Query: 164 GARQPRAGAAAAG-RGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAG 222
G P A A G GP + G P G G +G R G G + G
Sbjct: 915 GRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDP--GSHGRVGDRGPAGPPGGPGDKGDPG 972
Query: 223 GDGEDDGPVWIPSPA 237
DG+ GP P PA
Sbjct: 973 EDGQP-GPDGPPGPA 986
Score = 32.0 bits (71), Expect = 5.9
Identities = 59/201 (29%), Positives = 64/201 (31%), Gaps = 33/201 (16%)
Query: 56 ARPRGPLICHTGHEQAGREPG-PGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGR 114
A P+GP G EPG PG KG A P P GP +G
Sbjct: 848 AGPQGP----DGQPGVKGEPGEPGQ--KGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGT 901
Query: 115 QG---------SGLGAGPGAGTWAPAPPGV----SKPRCPG-RARPGEGQQ--QVTTARP 158
QG S GP AP P G K PG R PG + A P
Sbjct: 902 QGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGP 961
Query: 159 PAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAG-- 216
P P GP A TG+ VG G G R P AG
Sbjct: 962 PGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGI-----VGMPGQRGERGMPGLPGPAGTP 1016
Query: 217 ---GRSGAGGDGEDDGPVWIP 234
G +GA GD GPV P
Sbjct: 1017 GKVGPTGATGDKGPPGPVGPP 1037
Score = 31.6 bits (70), Expect = 7.7
Identities = 42/147 (28%), Positives = 54/147 (36%), Gaps = 14/147 (9%)
Query: 100 PGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRA----RPGEGQQQVTT 155
PGP + G G GP P P G+S+P A + G G Q
Sbjct: 152 PGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQ--VG 209
Query: 156 ARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGA 215
P ++ G PR G+ GAG TG P G G +GS R P G
Sbjct: 210 LMPGSV--GPVGPRGPQGLQGQQGGAGP--TGPPGEPGDP--GPMGPIGS-RGPEGPPGK 262
Query: 216 GGRSGAGGDGEDDGPV-WIPSPASRSY 241
G G G + G V + SP +R +
Sbjct: 263 PGEDGEPGRNGNPGEVGFAGSPGARGF 289
Score = 31.6 bits (70), Expect = 7.7
Identities = 40/163 (24%), Positives = 57/163 (34%), Gaps = 20/163 (12%)
Query: 1251 QAGRQALAAARGSWGP-GPS----SLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLL 1305
Q G + +G GP GP+ S +P PG EG PG L
Sbjct: 1141 QKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGN-------PGPL 1193
Query: 1306 GASQESSMAGRLGEAGGQAAPGQ-------GPSAESIAQEPSQEEKFPGEALTGLPAATP 1358
G + G +GEAG + PG+ GP A + LP T
Sbjct: 1194 GPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDESMPDPLPEFTE 1253
Query: 1359 EELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKS 1401
++ A + K P V A ++ E SP S + P ++
Sbjct: 1254 DQAAPDDKNKTD-PGVHATLKSLSSQIETMRSPDGSKKHPART 1295
>gi|110349721 titin isoform novex-3 [Homo sapiens]
Length = 5604
Score = 60.1 bits (144), Expect = 2e-08
Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 9/141 (6%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
T P + LK+ +V E V C ++GYP P VTWY++D +++ ++IT Q
Sbjct: 941 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI---DFQITFQSGI 997
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK-----IHQRWFAKLKRKA 391
L + ED+ + SA N G VS S L V E++ + +++ + KR
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFV 1057
Query: 392 AAK-LREIEQSWKHEKAVPGE 411
++ + + S E+A PGE
Sbjct: 1058 ESRDVVMTDTSLTEEQAGPGE 1078
Score = 57.8 bits (138), Expect = 1e-07
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
Q+ +E QP+ +V RF +++G P+P+++WYK++ L K +
Sbjct: 3240 QVLQELQPV--------TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF---KCKFL 3288
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
H G +TL L EDAA+Y A+N G+ + S L V
Sbjct: 3289 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 55.8 bits (133), Expect = 4e-07
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH- 332
+E + F++ +K+ + E V F C ++GYP P++ WYKD + +Y++
Sbjct: 1286 SEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG---ERYQMDFL 1342
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Q R +L++ ED IY A A N KG CSG L V
Sbjct: 1343 QDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1381
Score = 55.8 bits (133), Expect = 4e-07
Identities = 35/100 (35%), Positives = 46/100 (46%), Gaps = 8/100 (8%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP---KYEITH 332
E P F + + E+SD F C V G P PEV WYK + C P KY I+
Sbjct: 5377 EMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYK-----EYMCIEPDNIKYVISE 5431
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVG 372
+ HTL++ D+A Y+ A N G C G L +G
Sbjct: 5432 EKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMG 5471
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 243 LSVRPETSLSSNRLSHPS---SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFT 299
L++ T +S R S + SG++T + + E P F L+S +V + S VR
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
VTG P P V +Y+D E+ ++I+ +G+ ++L + ED+ Y +A NS
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSL---DFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 360 KGIVSCSGVLEV 371
G + + L V
Sbjct: 182 VGRATSTAELLV 193
Score = 48.1 bits (113), Expect = 8e-05
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E RF C VTGYP+P+V WY + + + ++ + + G H L + C+ D
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRK---SKRFRVRYDG-IHYLDIVDCKSYDT 1907
Query: 350 AIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
+ +A+N +G++ LE+ +++
Sbjct: 1908 GEVKVTAENPEGVIEHKVKLEIQQREDFR 1936
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/106 (22%), Positives = 47/106 (44%), Gaps = 3/106 (2%)
Query: 270 IAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
++ +T E + + K E + C+++G P+P VTW+++ L + K++
Sbjct: 4150 LSDITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQN---QKFQ 4206
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
H L + +D+ Y+ A+N+ G V L V +T
Sbjct: 4207 FEEVNCSHQLYIKDVNSQDSGKYKCVAENNSGAVESVSDLTVEPVT 4252
Score = 43.1 bits (100), Expect = 0.003
Identities = 35/126 (27%), Positives = 57/126 (45%), Gaps = 10/126 (7%)
Query: 253 SNRLSHPSSGRSTFCSIIAQLT---EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPE 309
S + H S + S I+ + E +P F L + V E V FTC + P PE
Sbjct: 3475 SEDIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPE 3534
Query: 310 VTWYKDD----TELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSC 365
+TW+ ++ T L R + K E + +L++ R ++ D+ Y+ A NS+G
Sbjct: 3535 MTWFHNNRPIPTGLRR---IIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAES 3591
Query: 366 SGVLEV 371
+ L V
Sbjct: 3592 TASLLV 3597
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+S V E S F ++G+P PEV+W++D + LP +I+ R
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-STLPGVQISFSDGRAK 64
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
L + + ++ Y A N G + + L V T
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAET 101
Score = 42.4 bits (98), Expect = 0.004
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 20/293 (6%)
Query: 261 SGRSTFCSIIA--QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+GRS+ I+ + + +P+F LK+ ++ E S + TG P P++ W K+
Sbjct: 1536 AGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1595
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG--IVSCSGVLEV---GT 373
+ + PK I L++ +D+A Y A+A N G C +EV
Sbjct: 1596 IVPH-KYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1654
Query: 374 MTEYK-IHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGA 432
E K I R + K AA +L + + E+ G++ K F++K
Sbjct: 1655 EPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRL 1714
Query: 433 QAPGPS------VPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPEN 486
+ GP+ P +P + W + L +IN F + + ++
Sbjct: 1715 KRFGPAHFECRLTPIGDPT--MVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDS 1772
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRK-PELEKAA 538
G Y D +K+E ++ + E ++GL++ ELE+ A
Sbjct: 1773 GIITCRATNKYGTD--HTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMA 1823
Score = 40.8 bits (94), Expect = 0.013
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F ++S+ V E F C GYP+P VTWY +D + R + I N
Sbjct: 3944 PSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRN---QNFIIHSLENYSI 4000
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKI 379
L L ++ N G V + +L+V ++ +
Sbjct: 4001 LTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDV 4041
Score = 40.4 bits (93), Expect = 0.017
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 236 PASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFET-----TLKSRSV 290
P+ + L+S R L +S +G T +++ QL + + ET T+K+ V
Sbjct: 2836 PSDKHRLVSERKVHKLMLQNISPSDAGEYT--AVVGQLECKAKLFVETLHITKTMKNIEV 2893
Query: 291 SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAA 350
E F C V+ + P + W K+ E++ K++I QG H L + ED+A
Sbjct: 2894 PETKTASFECEVSHFNVPSM-WLKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSA 2949
Query: 351 IY 352
Y
Sbjct: 2950 EY 2951
Score = 40.0 bits (92), Expect = 0.022
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E +FE ++S++V + SD F V G P+PE WYK+ +++R + Y + N
Sbjct: 2076 EAPKIFER-IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRI--YWYWPEDN 2132
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED+A A N G S L V
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2168
Score = 40.0 bits (92), Expect = 0.022
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 9/106 (8%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEITHQGNR 336
P T L+ SE RF C V+G + +V+WY D ++ R+ + ++E T+Q
Sbjct: 3345 PAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ--- 3400
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQR 382
L++ ED Y A N+ G VS + L + E +H+R
Sbjct: 3401 --LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL-EAPESILHER 3443
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 1476 PQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQR--PVGEVGRSAGDEGPAAL 1533
PQV++++ + SG +C + ++W K+++ G + D L
Sbjct: 3239 PQVLQEL--QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 1534 AIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPM 1588
+++A P D VY C N++G A+T LS EV +E V +TP+
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3351
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL-DRYCGLPKYE 329
+QL +P+F S E RF V G P PE W+ D ++ + Y K
Sbjct: 1449 SQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY--THKVV 1506
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
I G + +L + D+ + AQN G S S +L V + E+++ + KLK
Sbjct: 1507 IKEDGTQ-SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV-EHQVKPMFVEKLK 1563
Score = 33.9 bits (76), Expect = 1.6
Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F L R V E++ + F V G P P V WY++ + L+ + ++ GN
Sbjct: 5180 EMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPD---ERIKMERVGN 5236
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKG 361
+L++ ++ + Y A N G
Sbjct: 5237 VCSLEISNIQKGEGGEYMCHAVNIIG 5262
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 284 TLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYR 343
TLK+ +V+E D FT +T V W K+ L+ KY I+ +G ++L++
Sbjct: 2712 TLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLE---SNEKYAISVKGTIYSLRIKN 2768
Query: 344 CREEDAAIY 352
C D ++Y
Sbjct: 2769 CAIVDESVY 2777
Score = 32.7 bits (73), Expect = 3.5
Identities = 29/98 (29%), Positives = 35/98 (35%), Gaps = 7/98 (7%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD---RYCGLPKYEIT 331
E P F T + + E V F C V G P+P V W K L RY K
Sbjct: 1078 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRY----KVSYN 1133
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
Q L + +DA Y +N G S S L
Sbjct: 1134 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 32.3 bits (72), Expect = 4.5
Identities = 20/73 (27%), Positives = 29/73 (39%), Gaps = 5/73 (6%)
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR-HTLQLYRCREEDAAIYQASA 356
F C+V G P P V WYKD + ++ + G H L + + D Y+ A
Sbjct: 5533 FQCLVRGSPRPTVYWYKDGKLVQG----RRFTVEESGTGFHNLFITSLVKSDEGEYRCVA 5588
Query: 357 QNSKGIVSCSGVL 369
N G+ L
Sbjct: 5589 TNKSGMAESFAAL 5601
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 60.1 bits (144), Expect = 2e-08
Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 9/141 (6%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
T P + LK+ +V E V C ++GYP P VTWY++D +++ ++IT Q
Sbjct: 941 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI---DFQITFQSGI 997
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK-----IHQRWFAKLKRKA 391
L + ED+ + SA N G VS S L V E++ + +++ + KR
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFV 1057
Query: 392 AAK-LREIEQSWKHEKAVPGE 411
++ + + S E+A PGE
Sbjct: 1058 ESRDVVMTDTSLTEEQAGPGE 1078
Score = 57.8 bits (138), Expect = 1e-07
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
Q+ +E QP+ +V RF +++G P+P+++WYK++ L K +
Sbjct: 3240 QVLQELQPV--------TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF---KCKFL 3288
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
H G +TL L EDAA+Y A+N G+ + S L V
Sbjct: 3289 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 55.8 bits (133), Expect = 4e-07
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH- 332
+E + F++ +K+ + E V F C ++GYP P++ WYKD + +Y++
Sbjct: 1286 SEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG---ERYQMDFL 1342
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Q R +L++ ED IY A A N KG CSG L V
Sbjct: 1343 QDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1381
Score = 55.5 bits (132), Expect = 5e-07
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Query: 262 GRSTFCSIIAQLTEETQ-----PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
G S + I +T ++ P F+ L++ +V S+ C VTG+P+P V WY+
Sbjct: 30906 GESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQG 30965
Query: 317 TELDRYCGLPKYEITH-QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ GL KY I +G H L + ++DA +YQ A N G VS + LEV
Sbjct: 30966 KEIIA-DGL-KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 31019
Score = 55.1 bits (131), Expect = 7e-07
Identities = 36/100 (36%), Positives = 47/100 (47%), Gaps = 5/100 (5%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CSI +L + P F LK V + SDV C VTG P EVTW K++ E+
Sbjct: 4945 CSI--ELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIR---SSK 4999
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
KY +T + + L + +C D YQ N G SCS
Sbjct: 5000 KYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCS 5039
Score = 55.1 bits (131), Expect = 7e-07
Identities = 35/105 (33%), Positives = 53/105 (50%), Gaps = 4/105 (3%)
Query: 268 SIIAQLTEETQPLFETTLK-SRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
S AQL + P F L+ SR V +D R+ C + G PE +V WYKD+TE+
Sbjct: 7294 SCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQE---SS 7350
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
K+ ++ + L+++ ED+ Y A N+ G S S L+V
Sbjct: 7351 KFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV 7395
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 243 LSVRPETSLSSNRLSHPS---SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFT 299
L++ T +S R S + SG++T + + E P F L+S +V + S VR
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
VTG P P V +Y+D E+ ++I+ +G+ ++L + ED+ Y +A NS
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSL---DFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 360 KGIVSCSGVLEV 371
G + + L V
Sbjct: 182 VGRATSTAELLV 193
Score = 52.4 bits (124), Expect = 4e-06
Identities = 32/106 (30%), Positives = 43/106 (40%), Gaps = 3/106 (2%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYC 323
S C+ +TE P F + KS + +F C VTG P E W KD L
Sbjct: 3536 SVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALS--- 3592
Query: 324 GLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
P + I+ N+H L+L +D +Y A N G C L
Sbjct: 3593 PSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAEL 3638
Score = 51.6 bits (122), Expect = 7e-06
Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 17/141 (12%)
Query: 261 SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD 320
+GR ++++ L P F T L+ + V C V G PE V+WYK DT+L
Sbjct: 6064 AGRDVCGALVSTLEP---PYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLR 6120
Query: 321 RYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIH 380
P+Y N TL + D+ Y A+NS G S + T ++I
Sbjct: 6121 ---PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTAS--------SKTVFRIQ 6169
Query: 381 QRWFAKLKRKAAAKLREIEQS 401
+R +L A +L++IEQ+
Sbjct: 6170 ER---QLPPSFARQLKDIEQT 6187
Score = 51.6 bits (122), Expect = 7e-06
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 249 TSLSSNRLSHPSSGRSTFCSIIAQLTEET-QPLFETTLKSRSVSEDSDVRFTCIVTGYPE 307
T ++ N+ S ++ T+ T +P+F+ L + E V F V+G P
Sbjct: 31764 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPP 31823
Query: 308 PEVTWYKDDTELDRYCGLPKYEITHQG-NRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
P + W KD L P EI H+G + + L + ED Y+ +A N+ G SC
Sbjct: 31824 PTLKWEKDGQPLSLG---PNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880
Query: 367 GVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVD-TLR 416
L+V + K +E + +HE+ V ++D TLR
Sbjct: 31881 AHLQV-----------------ERLRYKKQEFKSKEEHERHVQKQIDKTLR 31914
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
S R T SI +LT P +K + + +C + G P P++ WY+ EL
Sbjct: 30514 SRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL 30573
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
+ KY+++ G HTL + +ED +Y A N G V S L
Sbjct: 30574 IQ---SRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 30620
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F + +S++++E +V FTC ++G P PE+ W+K++ + + I+ N ++
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNV---SISRSRNVYS 33190
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
L++ D+ Y A+N +G S + L V + E
Sbjct: 33191 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVE 33228
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/110 (30%), Positives = 47/110 (42%), Gaps = 3/110 (2%)
Query: 262 GRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR 321
GRS+ + I L P F LK + S + CIV G + W+KDD E+
Sbjct: 4658 GRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEIS- 4716
Query: 322 YCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
KY+ + N L++ + D+ Y SA N G CSG L V
Sbjct: 4717 --ASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTV 4764
Score = 49.7 bits (117), Expect = 3e-05
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 4/102 (3%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSD-VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
AQL+ + P F L++ V++ + ++ C ++G PE +V+W+++D+EL KY
Sbjct: 6356 AQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESW---KYN 6412
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
++ + L + ED+ Y A N G SCS L V
Sbjct: 6413 MSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTV 6454
Score = 49.3 bits (116), Expect = 4e-05
Identities = 37/148 (25%), Positives = 67/148 (45%), Gaps = 8/148 (5%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
++P+ T L+ +VS DS +F TG P P W KD + + KY+++
Sbjct: 32850 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG---GKYKLSEDKGG 32906
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIH----QRWFAKLKRKAA 392
L++++ D+ +Y + +NS G VS S L + + + + Q+ +K A
Sbjct: 32907 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKA 32966
Query: 393 AKLREIEQ-SWKHEKAVPGEVDTLRKLS 419
EI Q + + E+ E + KL+
Sbjct: 32967 VVQEEISQKALRSEEIKMSEAKSQEKLA 32994
Score = 48.1 bits (113), Expect = 8e-05
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E RF C VTGYP+P+V WY + + + ++ + + G H L + C+ D
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRK---SKRFRVRYDG-IHYLDIVDCKSYDT 1907
Query: 350 AIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
+ +A+N +G++ LE+ +++
Sbjct: 1908 GEVKVTAENPEGVIEHKVKLEIQQREDFR 1936
Score = 48.1 bits (113), Expect = 8e-05
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 9/133 (6%)
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F C +TG P+ V+WY D E+ + K+ I+ T Q+ R E++ Y A+
Sbjct: 4881 FECQITGTPKIRVSWYLDGNEI---TAIQKHGISFIDGLATFQISGARVENSGTYVCEAR 4937
Query: 358 NSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRK 417
N G SCS L+V K + +LK K ++E + P EV L+
Sbjct: 4938 NDAGTASCSIELKV------KEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKN 4991
Query: 418 LSPDRFQRKRRLS 430
R +K L+
Sbjct: 4992 NREIRSSKKYTLT 5004
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/96 (30%), Positives = 41/96 (42%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F L +++ +VRF +T +PEP VTWYK ++ KY
Sbjct: 31687 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG 31746
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ L + +D A Y A+N G SC L V
Sbjct: 31747 LYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782
Score = 47.0 bits (110), Expect = 2e-04
Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 268 SIIAQLTEETQPL-FETTLKSRSVSEDSDVRFTC-IVTGYPEPEVTWYKDDTELDRYCGL 325
S I Q +T+P+ +++++V +D+D F I YPE +++WYK +L+
Sbjct: 8644 SFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPS--- 8700
Query: 326 PKYEITHQGNRHTLQLYRCREEDAAIYQ 353
K+EI+ G+RHTL++ C+ +D Y+
Sbjct: 8701 DKFEISIDGDRHTLRVKNCQLKDQGNYR 8728
Score = 45.1 bits (105), Expect = 7e-04
Identities = 37/112 (33%), Positives = 51/112 (45%), Gaps = 6/112 (5%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
+SG+ + CS AQ+ P F L+ VS C + G PE V+WYK DT+L
Sbjct: 7945 ASGKDS-CS--AQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKL 8001
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Y++ + N TL + D+ Y A+NS G VS S L V
Sbjct: 8002 R---PTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTV 8050
Score = 44.7 bits (104), Expect = 9e-04
Identities = 34/103 (33%), Positives = 45/103 (43%), Gaps = 5/103 (4%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYC 323
S CS I + E P F K V ++ DV V G P E+TW+KD+T L
Sbjct: 4380 SDHCSSIVIVKES--PYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILR--- 4434
Query: 324 GLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
KY+ Q + +LQ+ + DA YQ N G CS
Sbjct: 4435 SGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICS 4477
Score = 44.7 bits (104), Expect = 9e-04
Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
C V G PE ++WYK+ T+L P Y++ + N +L + + D Y A NS
Sbjct: 7041 CKVDGTPEIRISWYKEHTKLR---SAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNS 7097
Query: 360 KGIVSCSGVLEV 371
G V+ S VL +
Sbjct: 7098 VGAVASSAVLVI 7109
Score = 44.3 bits (103), Expect = 0.001
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 6/104 (5%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDV-RFTCIVTGYPEPEVTWYKDDTELDRY 322
S C+ + +TE P F L++ + + D R C + G PE V W++++ EL
Sbjct: 5410 SDSCTTMLLVTEP--PKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELP-- 5465
Query: 323 CGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
KY +T + +Q+ ED+ + AQN G SCS
Sbjct: 5466 -ASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCS 5508
Score = 43.9 bits (102), Expect = 0.002
Identities = 47/154 (30%), Positives = 64/154 (41%), Gaps = 13/154 (8%)
Query: 248 ETSLS-SNRLSHPSSGRSTFCSIIAQLTE---ETQPLFETTLKSRSVSEDSDVRFTCIVT 303
+T LS S + S +S S A+LT + P F+ S V F C VT
Sbjct: 6236 QTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVT 6295
Query: 304 GYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
G +TW KD+ E+ R G Y IT GN L++ + + D+ Y A N G
Sbjct: 6296 GAQPMRITWSKDNKEI-RPGG--NYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKD 6352
Query: 364 SCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLRE 397
CS L V K ++ KL+ AK E
Sbjct: 6353 MCSAQLSV------KEPPKFVKKLEASKVAKQGE 6380
Score = 43.5 bits (101), Expect = 0.002
Identities = 31/99 (31%), Positives = 41/99 (41%), Gaps = 3/99 (3%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
LT + P F + DS V F I+ G P ++ W+KDD EL PK I
Sbjct: 5324 LTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVEL---VSGPKCFIGL 5380
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+G+ L LY Y N G SC+ +L V
Sbjct: 5381 EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLV 5419
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
T + P ++S V + RF V P EV WY + EL K T+
Sbjct: 32369 TLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNT 32425
Query: 334 GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV--GTMTEYKIHQR 382
TL++ C +D+ Y+A N KG S L+V G T Y +R
Sbjct: 32426 SGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRR 32476
Score = 43.1 bits (100), Expect = 0.003
Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 16/141 (11%)
Query: 236 PASRSYLLSVRPETS-LSSNRLSHPSSGR----------STFCSIIAQLTEETQPLFETT 284
PAS Y ++ + + N LS SG ST CS ++ + P+F +
Sbjct: 5465 PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCS--TKVIVKEPPVFSSF 5522
Query: 285 LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRC 344
++++V C ++G P EV WYKD +L KY+I + ++ +
Sbjct: 5523 PPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLR---SSKKYKIASKNFHTSIHILNV 5579
Query: 345 REEDAAIYQASAQNSKGIVSC 365
D Y AQN G +C
Sbjct: 5580 DTSDIGEYHCKAQNEVGSDTC 5600
Score = 43.1 bits (100), Expect = 0.003
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREED 348
++ SD+ V G PEP++ W K D ELD K + + G R T + C D
Sbjct: 29058 TIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL---CEKVSLQYTGKRATAVIKFCDRSD 29114
Query: 349 AAIYQASAQNSKGIVSCSGVLEV 371
+ Y + +N+ G + S +++V
Sbjct: 29115 SGKYTLTVKNASGTKAVSVMVKV 29137
Score = 42.7 bits (99), Expect = 0.003
Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 257 SHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
S+P S+ +I E P F+ S ++ F C VTG ++TW KD+
Sbjct: 7191 SNPLGTASSSAKLILS-EHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDN 7249
Query: 317 TELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ R G Y++T N TL + + + DA Y A N G SCS L V
Sbjct: 7250 REI-RPGG--NYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGV 7301
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+S V E S F ++G+P PEV+W++D + LP +I+ R
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-STLPGVQISFSDGRAK 64
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
L + + ++ Y A N G + + L V T
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAET 101
Score = 42.4 bits (98), Expect = 0.004
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 20/293 (6%)
Query: 261 SGRSTFCSIIA--QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+GRS+ I+ + + +P+F LK+ ++ E S + TG P P++ W K+
Sbjct: 1536 AGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1595
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG--IVSCSGVLEV---GT 373
+ + PK I L++ +D+A Y A+A N G C +EV
Sbjct: 1596 IVPH-KYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1654
Query: 374 MTEYK-IHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGA 432
E K I R + K AA +L + + E+ G++ K F++K
Sbjct: 1655 EPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRL 1714
Query: 433 QAPGPS------VPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPEN 486
+ GP+ P +P + W + L +IN F + + ++
Sbjct: 1715 KRFGPAHFECRLTPIGDPT--MVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDS 1772
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRK-PELEKAA 538
G Y D +K+E ++ + E ++GL++ ELE+ A
Sbjct: 1773 GIITCRATNKYGTD--HTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMA 1823
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 8/101 (7%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEI 330
L +E + E KS V+E + C+V G PE +V W KD ++ RY + +
Sbjct: 5136 LVQEPAQIVEKA-KSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRY-----FSM 5189
Query: 331 THQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ + N + ++ ++D+ Y +N G SC L V
Sbjct: 5190 SFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV 5230
Score = 42.4 bits (98), Expect = 0.004
Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 273 LTEETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
L E P + ++ +S V ++V V G P P V+W KD T L G+ +
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI---K 19343
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ Q N TL+L+ +D+ Y +A+NS G S + L+V
Sbjct: 19344 MAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 19385
Score = 42.0 bits (97), Expect = 0.006
Identities = 31/106 (29%), Positives = 43/106 (40%), Gaps = 4/106 (3%)
Query: 267 CSIIAQLTEET-QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGL 325
C+ Q+++ T P F LK + S V C V G P V+W+ + E+
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEIS---SG 7725
Query: 326 PKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
KY+ T N L + E D+ Y A N G CS L V
Sbjct: 7726 RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV 7771
Score = 42.0 bits (97), Expect = 0.006
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E + +F L + VSE ++ C V+ P EV WYK D E+ +YEI +G
Sbjct: 12460 EEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIE---TGRYEILTEGR 12515
Query: 336 RHTLQLYRCREEDAAIYQASAQNSK 360
+ L + EDA Y +S+
Sbjct: 12516 KRILVIQNAHLEDAGNYNCRLPSSR 12540
Score = 41.6 bits (96), Expect = 0.007
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 5/88 (5%)
Query: 271 AQLTEETQPL-FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
A+L E +P+ F +++ VSE F C V+ + + VTWYK TEL KY
Sbjct: 8825 AELRIEAEPIQFTKRIQNIVVSEHQSATFECEVS-FDDAIVTWYKGPTELTE---SQKYN 8880
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQ 357
+ G H + ++ +D +Y A+
Sbjct: 8881 FRNDGRCHYMTIHNVTPDDEGVYSVIAR 8908
Score = 41.2 bits (95), Expect = 0.010
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
C V G PE V WYKD L K++ + +L++ +DA Y QN+
Sbjct: 5725 CKVAGTPELSVEWYKDGKLLT---SSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNN 5781
Query: 360 KGIVSCSGVLEV 371
G SC+ V++V
Sbjct: 5782 VGKSSCTAVVDV 5793
Score = 41.2 bits (95), Expect = 0.010
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCR 345
+S V+ C V G PE W+KD EL KY+I+ L++
Sbjct: 7593 ESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSD---NKYKISFFNKVSGLKIINVA 7649
Query: 346 EEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
D+ +Y QN G SC+ L+V T
Sbjct: 7650 PSDSGVYSFEVQNPVGKDSCTASLQVSDRT 7679
Score = 40.8 bits (94), Expect = 0.013
Identities = 37/153 (24%), Positives = 60/153 (39%), Gaps = 12/153 (7%)
Query: 257 SHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
+H ++G + S L + P+F + +DV C + G P V+WYKD
Sbjct: 7380 AHNAAGSA---SSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDK 7436
Query: 317 TELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
EL KY+I + ++ + D YQ A N G +C G + +
Sbjct: 7437 RELR---SGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIAL----- 7488
Query: 377 YKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVP 409
K R+ KL + +E++ E A P
Sbjct: 7489 -KAPPRFVKKLSDISTVVGKEVQLQTTIEGAEP 7520
Score = 40.4 bits (93), Expect = 0.017
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 236 PASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFET-----TLKSRSV 290
P+ + L+S R L +S +G T +++ QL + + ET T+K+ V
Sbjct: 2836 PSDKHRLVSERKVHKLMLQNISPSDAGEYT--AVVGQLECKAKLFVETLHITKTMKNIEV 2893
Query: 291 SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAA 350
E F C V+ + P + W K+ E++ K++I QG H L + ED+A
Sbjct: 2894 PETKTASFECEVSHFNVPSM-WLKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSA 2949
Query: 351 IY 352
Y
Sbjct: 2950 EY 2951
Score = 40.4 bits (93), Expect = 0.017
Identities = 28/110 (25%), Positives = 42/110 (38%), Gaps = 3/110 (2%)
Query: 262 GRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR 321
G S+ + + L + P F L S + C V+G W+KD E+
Sbjct: 5220 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIST 5279
Query: 322 YCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
KY + +L++ ED A Y N G +CSG+L V
Sbjct: 5280 SA---KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTV 5326
Score = 40.0 bits (92), Expect = 0.022
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E +FE ++S++V + SD F V G P+PE WYK+ +++R + Y + N
Sbjct: 2076 EAPKIFER-IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRI--YWYWPEDN 2132
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED+A A N G S L V
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2168
Score = 40.0 bits (92), Expect = 0.022
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 9/106 (8%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEITHQGNR 336
P T L+ SE RF C V+G + +V+WY D ++ R+ + ++E T+Q
Sbjct: 3345 PAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ--- 3400
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQR 382
L++ ED Y A N+ G VS + L + E +H+R
Sbjct: 3401 --LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL-EAPESILHER 3443
Score = 40.0 bits (92), Expect = 0.022
Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 3/97 (3%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQG 334
+E E S+ + + + C VTG P ++TW+ +D E+ K+ ++
Sbjct: 4296 KEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKE---SSKHRMSFVE 4352
Query: 335 NRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ L+L ED+ Y AQN G CS ++ V
Sbjct: 4353 STAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIV 4389
Score = 40.0 bits (92), Expect = 0.022
Identities = 33/113 (29%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 260 SSGRSTFCSIIAQLTEE-TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
S G+S C++ +++ P F LK + + V C V+G V W++D E
Sbjct: 6722 SVGKSN-CTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNE 6780
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ PK + + N TL L D IY A N G CS VL V
Sbjct: 6781 I---VSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTV 6830
Score = 40.0 bits (92), Expect = 0.022
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 257 SHPSSGRSTFCSIIAQLTE-ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKD 315
++P S+ +I LTE + P F+ L F C VTG +V+W KD
Sbjct: 8132 TNPIGSASSSARLI--LTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKD 8189
Query: 316 DTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ R G KY+I++ N L + + + D+ Y A N G SC+ L +
Sbjct: 8190 SREI-RSGG--KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI 8242
Score = 39.7 bits (91), Expect = 0.028
Identities = 26/94 (27%), Positives = 39/94 (41%), Gaps = 3/94 (3%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
LT + P+F + SDV C ++G P EV W KD ++ K++IT
Sbjct: 6452 LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVR---NSKKFKITS 6508
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+ +L + D Y A N G +CS
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCS 6542
Score = 39.7 bits (91), Expect = 0.028
Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 11/96 (11%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEI 330
A++ E+ +P+ TT + C+VTG PE W+KD EL K+ I
Sbjct: 6645 ARIIEKPEPMTVTT--------GNPFALECVVTGTPELSAKWFKDGRELS---ADSKHHI 6693
Query: 331 THQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
T +L++ D +Y +NS G +C+
Sbjct: 6694 TFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCT 6729
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 13/124 (10%)
Query: 248 ETSLSSNRLSHPSSGRSTFCSIIAQLTEE--TQPLFETTLKSR--------SVSEDSDVR 297
ET S + H +S ++ + EE T +TTL +R +V E R
Sbjct: 32520 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESAR 32579
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F+C G P P VTW + L ++++T + T ++ + D Y +
Sbjct: 32580 FSCDTDGEPVPTVTWLRKGQVLSTSA---RHQVTTTKYKSTFEISSVQASDEGNYSVVVE 32636
Query: 358 NSKG 361
NS+G
Sbjct: 32637 NSEG 32640
Score = 38.9 bits (89), Expect = 0.049
Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 3/110 (2%)
Query: 262 GRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR 321
G S+ + L + P F L++ + R C + G V+W+KD E+
Sbjct: 4096 GSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEI-- 4153
Query: 322 YCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+Y I +L++ R DA + A NS G SG L V
Sbjct: 4154 -AASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIV 4202
Score = 38.5 bits (88), Expect = 0.063
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 7/98 (7%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKY 328
A LT + P FE T S V + FT ++ G P +V W+K EL C +
Sbjct: 6826 AVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLE 6885
Query: 329 EITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+ + L+L+ + ++ Y N G SC+
Sbjct: 6886 DFVTE-----LELFEVQPLESGDYSCLVTNDAGSASCT 6918
Score = 38.1 bits (87), Expect = 0.083
Identities = 33/116 (28%), Positives = 48/116 (41%), Gaps = 8/116 (6%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYC 323
S+ CS A++T P F ++S S F + G VTW KD E+
Sbjct: 4473 SSICS--ARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDD 4530
Query: 324 GLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV---GTMTE 376
+ +T + N +L L + Y A+N GI CS +L V T+TE
Sbjct: 4531 NI---RMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITE 4583
Score = 38.1 bits (87), Expect = 0.083
Identities = 29/110 (26%), Positives = 41/110 (37%), Gaps = 3/110 (2%)
Query: 262 GRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR 321
G+S+ +++ P F LK+ + C V G V W+ + T++
Sbjct: 5783 GKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKI-- 5840
Query: 322 YCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
KY+ T N TLQL D Y A N G C VL V
Sbjct: 5841 -VSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTV 5889
Score = 37.7 bits (86), Expect = 0.11
Identities = 38/162 (23%), Positives = 58/162 (35%), Gaps = 26/162 (16%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYC 323
STF ++ Q + P F L+ + V F C ++G V+WYKD L
Sbjct: 8045 STFLTVQEQ---KLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLK--- 8098
Query: 324 GLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL-------------- 369
P + + N TL +++ A Y +A N G S S L
Sbjct: 8099 DSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIR 8158
Query: 370 ------EVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHE 405
VG +++ H +K A REI K++
Sbjct: 8159 LAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQ 8200
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCR 345
+ + + +R + I+ G P P+VTW K+D + + ++T G++ L++
Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKA---RIDVTPVGSK--LEIRNAA 17280
Query: 346 EEDAAIYQASAQNSKG 361
ED IY + +N G
Sbjct: 17281 HEDGGIYSLTVENPAG 17296
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
+ +R +V G P P VTW+KD E+++ + EIT +L + +
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM---EITDVLGSTSLFVRDATRDHR 28026
Query: 350 AIYQASAQNSKG 361
+Y A+N+ G
Sbjct: 28027 GVYTVEAKNASG 28038
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 1476 PQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQR--PVGEVGRSAGDEGPAAL 1533
PQV++++ + SG +C + ++W K+++ G + D L
Sbjct: 3239 PQVLQEL--QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 1534 AIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPM 1588
+++A P D VY C N++G A+T LS EV +E V +TP+
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3351
Score = 37.4 bits (85), Expect = 0.14
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 3/105 (2%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CS ++ + P F +++ + S F V G P +TW KDD LD
Sbjct: 5036 CSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDED---D 5092
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
I+ + TLQ+ + Y A+N G+ C L V
Sbjct: 5093 NVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLV 5137
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/110 (26%), Positives = 42/110 (38%), Gaps = 3/110 (2%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
S G +++ + P F LK + V F C + G +V+WYKD L
Sbjct: 7097 SVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLL 7156
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
L + + N TLQ+ + + Y SA N G S S L
Sbjct: 7157 KDDANL---QTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 3/142 (2%)
Query: 230 PVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRS 289
P W S A ++L + T S +S + A+L +P F L+
Sbjct: 3595 PNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQ 3654
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
+ + V C V + VTW KD +L Y+I + TL++ + +D+
Sbjct: 3655 SAINKKVHLECQVDEDRKVTVTWSKDGQKLPPG---KDYKICFEDKIATLEIPLAKLKDS 3711
Query: 350 AIYQASAQNSKGIVSCSGVLEV 371
Y +A N G SCS + V
Sbjct: 3712 GTYVCTASNEAGSSSCSATVTV 3733
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 14/145 (9%)
Query: 237 ASRSYLLSVRPETS-LSSNRLSHPSSGRSTFCSII---------AQLTEETQPLFETTLK 286
AS Y S T+ L ++L SG T CS LT + P F +
Sbjct: 4717 ASEKYKFSFHDNTAFLEISQLEGTDSGTYT-CSATNKAGHNQCSGHLTVKEPPYFVEKPQ 4775
Query: 287 SRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCRE 346
S+ V+ ++ V+ +V G + W+KD+ EL + G + + +L+L+ +
Sbjct: 4776 SQDVNPNTRVQLKALVGGTAPMTIKWFKDNKEL--HSGAAR-SVWKDDTSTSLELFAAKA 4832
Query: 347 EDAAIYQASAQNSKGIVSCSGVLEV 371
D+ Y N G + L V
Sbjct: 4833 TDSGTYICQLSNDVGTATSKATLFV 4857
Score = 36.2 bits (82), Expect = 0.31
Identities = 36/133 (27%), Positives = 47/133 (35%), Gaps = 30/133 (22%)
Query: 250 SLSSNRLSHPSSGRSTFCSI--IAQLTEETQ-----------PLFETTLKSRSVSEDSDV 296
S+SS + S S+F I + QL T P E S+ E +
Sbjct: 33287 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 33346
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH--------TLQLYRCREED 348
C TG P PEVTW CG K QG H TL + +++D
Sbjct: 33347 TVACAFTGEPTPEVTW---------SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQD 33397
Query: 349 AAIYQASAQNSKG 361
+Y S N G
Sbjct: 33398 GGLYTLSLGNEFG 33410
Score = 35.8 bits (81), Expect = 0.41
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASA 356
R C + G P +VTW+K++ EL + Y + + L + + ED+ Y A
Sbjct: 3756 RLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEA---ILDITDVKVEDSGSYSCEA 3812
Query: 357 QNSKGIVSCS 366
N G SCS
Sbjct: 3813 VNDVGSDSCS 3822
Score = 35.8 bits (81), Expect = 0.41
Identities = 25/102 (24%), Positives = 38/102 (37%), Gaps = 2/102 (1%)
Query: 270 IAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
+ + + P F L S +V+ + G V W+KD E+ R
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIW 7540
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
I++ N TLQ R +A Y +N G+ C L V
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 35.8 bits (81), Expect = 0.41
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 7/96 (7%)
Query: 275 EETQPLFETTLKSRS----VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR---YCGLPK 327
+E P + L R V V VTG P P++ W K++T +++ + K
Sbjct: 15391 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 15450
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
E++ + L + + ED Y +A N G V
Sbjct: 15451 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSV 15486
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/100 (23%), Positives = 40/100 (40%), Gaps = 3/100 (3%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
++ + P+ + ++ V+ +FTC + P W+K E+ K I
Sbjct: 3449 EMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE---SDKCSIR 3505
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+L++ R + D Y A N G VSC+ L V
Sbjct: 3506 SSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 3545
Score = 35.4 bits (80), Expect = 0.54
Identities = 21/98 (21%), Positives = 40/98 (40%), Gaps = 3/98 (3%)
Query: 268 SIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPK 327
S ++ + P F TL+ + ++ C V+G E++W+KD ++ K
Sbjct: 3820 SCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIR---SSKK 3876
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSC 365
Y + Q + L+++ D Y+ N G C
Sbjct: 3877 YRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGC 3914
Score = 35.4 bits (80), Expect = 0.54
Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 20/143 (13%)
Query: 237 ASRSYLLSVRPET-SLSSNRLSHPSSGRSTF----------CSIIAQLTEETQPLFETTL 285
+ R Y ++ T +L+ N L SG T CS A LT P F
Sbjct: 7724 SGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECS--APLTVREPPSFVQKP 7781
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP--KYEITHQGNRHTLQLYR 343
V ++V FT IV G P V+W+K +EL +P + ++ + + L+L+
Sbjct: 7782 DPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSEL-----VPGDRCNVSLEDSVAELELFD 7836
Query: 344 CREEDAAIYQASAQNSKGIVSCS 366
+ Y N G SC+
Sbjct: 7837 VDTSQSGEYTCIVSNEAGKASCT 7859
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 281 FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQ 340
F LK +V E RF C++T E V W K D K++I G +H L
Sbjct: 11488 FAVPLKDVTVPERRQARFECVLT--REANVIWSKGP---DIIKSSDKFDIIADGKKHILV 11542
Query: 341 LYRCREEDAAIYQASAQNSK 360
+ + +D +Y A + K
Sbjct: 11543 INDSQFDDEGVYTAEVEGKK 11562
Score = 35.4 bits (80), Expect = 0.54
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 268 SIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPK 327
S+ L E F L+ ++V+E D F+C ++ + V WY++ E+ K
Sbjct: 12812 SVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEG---KK 12867
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
Y+ G+ H L + CR +D Y ++ K
Sbjct: 12868 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRK 12900
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R V G PEP++TW K+ L R + ++ R LQ+ D Y S
Sbjct: 17926 IRILARVKGRPEPDITWTKEGKVLVRE---KRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982
Query: 356 AQNSKGIVSCSGVLEV 371
A+NS G S ++ V
Sbjct: 17983 AKNSSGHAQGSAIVNV 17998
Score = 35.4 bits (80), Expect = 0.54
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1457 EGKQETLAKPRKAKDLLKAPQVIRKI--RVEQFPDASGSLKLWCQFFNILSDSVLTWAKD 1514
+G+ + +P +AKD+L+AP++ + R A +++ F +V TW KD
Sbjct: 27250 QGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV-TWRKD 27308
Query: 1515 QRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
++ +G R + + + L I Q + D G Y TI N G
Sbjct: 27309 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVG 27351
Score = 35.0 bits (79), Expect = 0.70
Identities = 22/70 (31%), Positives = 27/70 (38%), Gaps = 3/70 (4%)
Query: 302 VTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG 361
V G PE + WYKD L KY I+ + N L+ Y D+ Y N G
Sbjct: 4040 VAGTPELKPKWYKDGRPL---VASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVG 4096
Query: 362 IVSCSGVLEV 371
SC V
Sbjct: 4097 SSSCETTFTV 4106
Score = 35.0 bits (79), Expect = 0.70
Identities = 32/108 (29%), Positives = 40/108 (37%), Gaps = 4/108 (3%)
Query: 264 STFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYC 323
S CS + E P F L S V IV G+ V W KD E+ R
Sbjct: 6538 SDTCSCSVKFKEP--PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRES 6595
Query: 324 GLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
I+ N TLQL ++ Y +N G+ CS VL V
Sbjct: 6596 --ENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Score = 34.7 bits (78), Expect = 0.92
Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 3/88 (3%)
Query: 1473 LKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSA--GDEGP 1530
+KA VI++ ++E A G L + + W K R + E + + +
Sbjct: 3452 MKAAPVIKR-KIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI 3510
Query: 1531 AALAIVQASPVDCGVYRCTIHNEHGSAS 1558
++L I++ VDCG Y C NE+GS S
Sbjct: 3511 SSLEILRTQVVDCGEYTCKASNEYGSVS 3538
Score = 34.7 bits (78), Expect = 0.92
Identities = 40/162 (24%), Positives = 57/162 (35%), Gaps = 21/162 (12%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
L + P F T S+ V S V G + W+K + EL G Y IT
Sbjct: 4200 LIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKEL--VSGGSCY-ITK 4256
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSG------------------VLEVGTM 374
+ +L+LY + D+ Y N G V CS +L+ G
Sbjct: 4257 EALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDA 4316
Query: 375 TEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLR 416
T+ +K A REI++S KH + LR
Sbjct: 4317 TQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLR 4358
Score = 34.7 bits (78), Expect = 0.92
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
+P + S SV D++ ++G P+P +TW KD L + + +T +
Sbjct: 23229 EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ---TTRINVTDSLDLT 23285
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
TL + ++D Y + N G + S +E+ T+
Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTAS--IEIVTL 23320
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL-DRYCGLPKYE 329
+QL +P+F S E RF V G P PE W+ D ++ + Y K
Sbjct: 1449 SQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY--THKVV 1506
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
I G + +L + D+ + AQN G S S +L V + E+++ + KLK
Sbjct: 1507 IKEDGTQ-SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV-EHQVKPMFVEKLK 1563
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 3/84 (3%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
QP + + S+ D++ V G P P ++W KD L + + +
Sbjct: 24311 QPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQ---TTRVNVEETATST 24367
Query: 338 TLQLYRCREEDAAIYQASAQNSKG 361
L + ++D Y +A NS G
Sbjct: 24368 VLHIKEGNKDDFGKYTVTATNSAG 24391
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R +VTG P P W K++ ELD+ + I + G + L + +D Y +
Sbjct: 15122 LRIPAVVTGRPVPTKVWTKEEGELDK----DRVVIDNVGTKSELIIKDALRKDHGRYVIT 15177
Query: 356 AQNSKGIVSCSGVLEV 371
A NS G + +EV
Sbjct: 15178 ATNSCGSKFAAARVEV 15193
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDD--TELDRYCGLPKYEITHQGNRHTLQLYRCRE 346
+V +R V G P PEV W KD T+L R P+ +I + + L + +
Sbjct: 18212 TVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTR---SPRVKIDTRADSSKFSLTKAKR 18268
Query: 347 EDAAIYQASAQNSKG 361
D Y +A N+ G
Sbjct: 18269 SDGGKYVVTATNTAG 18283
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 284 TLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYR 343
TLK+ +V+E D FT +T V W K+ L+ KY I+ +G ++L++
Sbjct: 2712 TLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLE---SNEKYAISVKGTIYSLRIKN 2768
Query: 344 CREEDAAIY 352
C D ++Y
Sbjct: 2769 CAIVDESVY 2777
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 2/68 (2%)
Query: 1509 LTWAKDQR--PVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPE 1566
+TW+KD + P G+ + ++ A L I A D G Y CT NE GS+S ++
Sbjct: 3675 VTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVR 3734
Query: 1567 VLSGFISR 1574
F+ +
Sbjct: 3735 EPPSFVKK 3742
Score = 33.5 bits (75), Expect = 2.0
Identities = 19/72 (26%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + VRF I+ G P P W D +E+ Y + L + C D
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD---EHYTVETDNFSSVLTIKNCLRRDT 17578
Query: 350 AIYQASAQNSKG 361
YQ + N+ G
Sbjct: 17579 GEYQITVSNAAG 17590
Score = 33.5 bits (75), Expect = 2.0
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1511 WAKDQRPVGEVGRS--AGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAST 1559
W KD + + + G+ + D+G L I + D G+Y CT+ N GS S+
Sbjct: 32885 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 32935
Score = 33.1 bits (74), Expect = 2.7
Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 8/84 (9%)
Query: 1511 WAKDQ-RPVGEVGR----SAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSP 1565
W K + R + + GR GDE A L I + D G+YRC NEHG ++ L
Sbjct: 8487 WTKGKWRQLNQGGRVFIHQKGDE--AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Query: 1566 EVLSGFISREEGEVGEEIEMTPMV 1589
+ + EG++ ++ TP++
Sbjct: 8545 DERKK-QEKIEGDLRAMLKKTPIL 8567
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/146 (22%), Positives = 58/146 (39%), Gaps = 19/146 (13%)
Query: 252 SSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDV-RFTCIVTGYPEPEV 310
+++ +S PS ST I+ E + + + + V + +V + + G P P +
Sbjct: 25764 AADSVSEPSE--STGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVI 25821
Query: 311 TWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG----IVSC- 365
+W KD E++ + EI N L + C D Y + +N G V+C
Sbjct: 25822 SWAKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 25878
Query: 366 --------SGVLEVGTMTEYKIHQRW 383
+G LE+ +T K W
Sbjct: 25879 VLDKPGPPAGPLEINGLTAEKCSLSW 25904
Score = 32.7 bits (73), Expect = 3.5
Identities = 29/98 (29%), Positives = 35/98 (35%), Gaps = 7/98 (7%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD---RYCGLPKYEIT 331
E P F T + + E V F C V G P+P V W K L RY K
Sbjct: 1078 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRY----KVSYN 1133
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
Q L + +DA Y +N G S S L
Sbjct: 1134 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 32.7 bits (73), Expect = 3.5
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 274 TEETQPLFETT--LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
T+E +F L +V + + VTG PEP++TW K D L + + I
Sbjct: 13684 TQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQD---KRITIE 13740
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
+ + T+ + + D Y A N G + V+EV +
Sbjct: 13741 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCG--RATAVVEVNVL 13781
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 292 EDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAI 351
E+S+ R + G P P V+W K + D + + TL +Y C++ DA
Sbjct: 19996 ENSNFRLKIPIKGKPAPSVSWKKGE---DPLATDTRVSVESSAVNTTLIVYDCQKSDAGK 20052
Query: 352 YQASAQNSKG 361
Y + +N G
Sbjct: 20053 YTITLKNVAG 20062
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1489 DASGSLKLWCQFFNILSDSVLTWAKDQRPV--GEVGRSAGDEGPAALAIVQASPVDCGVY 1546
+ G +K C+ N + +TW R + E ++G A L + + +D G Y
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 1547 RCTIHNEHGSAST 1559
RC + N++G S+
Sbjct: 31640 RCKVVNDYGEDSS 31652
Score = 32.3 bits (72), Expect = 4.5
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 304 GYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
G P PE+TW +++ E K +I N L + C DA Y +NS G
Sbjct: 24050 GRPTPEITWSREEGEF-----TDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 24104
Query: 364 SCSGVLEV 371
S ++V
Sbjct: 24105 SAFVTVKV 24112
Score = 32.0 bits (71), Expect = 5.9
Identities = 23/96 (23%), Positives = 39/96 (40%), Gaps = 3/96 (3%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEI 330
A LT + P F + V +V FT ++ G P +V W++ EL + + I
Sbjct: 5885 AVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKG---DRCNI 5941
Query: 331 THQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
+ L+L+ + Y N+ G SC+
Sbjct: 5942 YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCT 5977
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/83 (25%), Positives = 31/83 (37%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F+ + +V D++ G P P VTW+KD+ L + + N
Sbjct: 22148 PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQ---TTRVNAESTENNSL 22204
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + ED Y NS G
Sbjct: 22205 LTIKDACREDVGHYVVKLTNSAG 22227
Score = 32.0 bits (71), Expect = 5.9
Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 8/99 (8%)
Query: 276 ETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
E +PLF+ + R V + T G P P V W K DT+L + +
Sbjct: 26181 EEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL-----RTRAYVDT 26235
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+R +L + D+ Y + QN S + V++V
Sbjct: 26236 TDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 26274
Score = 31.6 bits (70), Expect = 7.7
Identities = 37/163 (22%), Positives = 61/163 (37%), Gaps = 29/163 (17%)
Query: 936 PPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGC----LPRSEEAVVTASRNHEQT 991
PP + P++PPT P P + PE P KP +P + + VV +
Sbjct: 10541 PPPKKPEVPPTKVPEVPKAAVPEKKVPE--AIPPKPESPPPEVPEAPKEVVPEKK----- 10593
Query: 992 VLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPK--EERPGGV 1049
+PA PP + V V + P++ V ++ P PK E P V
Sbjct: 10594 ----------VPAAPPKKPEVTPV-----KVPEAPKEV-VPEKKVPVPPPKKPEVPPTKV 10637
Query: 1050 PCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQ 1092
P + + P + + +P P P + P+ P ++
Sbjct: 10638 PEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAE 10680
Score = 31.6 bits (70), Expect = 7.7
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + +R G P P W K D+ L + +I + TL + C DA
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL-----RADIHTTDSFSTLTVENCNRNDA 28423
Query: 350 AIYQASAQNSKGIVSCSGVLEV 371
Y + +N+ G S + ++V
Sbjct: 28424 GKYTLTVENNSGSKSITFTVKV 28445
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 60.1 bits (144), Expect = 2e-08
Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 9/141 (6%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
T P + LK+ +V E V C ++GYP P VTWY++D +++ ++IT Q
Sbjct: 895 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI---DFQITFQSGI 951
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK-----IHQRWFAKLKRKA 391
L + ED+ + SA N G VS S L V E++ + +++ + KR
Sbjct: 952 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFV 1011
Query: 392 AAK-LREIEQSWKHEKAVPGE 411
++ + + S E+A PGE
Sbjct: 1012 ESRDVVMTDTSLTEEQAGPGE 1032
Score = 57.8 bits (138), Expect = 1e-07
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
Q+ +E QP+ +V RF +++G P+P+++WYK++ L K +
Sbjct: 3194 QVLQELQPV--------TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF---KCKFL 3242
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
H G +TL L EDAA+Y A+N G+ + S L V
Sbjct: 3243 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 3282
Score = 55.8 bits (133), Expect = 4e-07
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH- 332
+E + F++ +K+ + E V F C ++GYP P++ WYKD + +Y++
Sbjct: 1240 SEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG---ERYQMDFL 1296
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Q R +L++ ED IY A A N KG CSG L V
Sbjct: 1297 QDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1335
Score = 55.5 bits (132), Expect = 5e-07
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Query: 262 GRSTFCSIIAQLTEETQ-----PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
G S + I +T ++ P F+ L++ +V S+ C VTG+P+P V WY+
Sbjct: 24601 GESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQG 24660
Query: 317 TELDRYCGLPKYEITH-QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ GL KY I +G H L + ++DA +YQ A N G VS + LEV
Sbjct: 24661 KEIIA-DGL-KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24714
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 243 LSVRPETSLSSNRLSHPS---SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFT 299
L++ T +S R S + SG++T + + E P F L+S +V + S VR
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
VTG P P V +Y+D E+ ++I+ +G+ ++L + ED+ Y +A NS
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSL---DFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 360 KGIVSCSGVLEV 371
G + + L V
Sbjct: 182 VGRATSTAELLV 193
Score = 51.6 bits (122), Expect = 7e-06
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 249 TSLSSNRLSHPSSGRSTFCSIIAQLTEET-QPLFETTLKSRSVSEDSDVRFTCIVTGYPE 307
T ++ N+ S ++ T+ T +P+F+ L + E V F V+G P
Sbjct: 25459 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPP 25518
Query: 308 PEVTWYKDDTELDRYCGLPKYEITHQG-NRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
P + W KD L P EI H+G + + L + ED Y+ +A N+ G SC
Sbjct: 25519 PTLKWEKDGQPLSLG---PNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 25575
Query: 367 GVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVD-TLR 416
L+V + K +E + +HE+ V ++D TLR
Sbjct: 25576 AHLQV-----------------ERLRYKKQEFKSKEEHERHVQKQIDKTLR 25609
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
S R T SI +LT P +K + + +C + G P P++ WY+ EL
Sbjct: 24209 SRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL 24268
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
+ KY+++ G HTL + +ED +Y A N G V S L
Sbjct: 24269 IQ---SRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24315
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F + +S++++E +V FTC ++G P PE+ W+K++ + + I+ N ++
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNV---SISRSRNVYS 26885
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
L++ D+ Y A+N +G S + L V + E
Sbjct: 26886 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVE 26923
Score = 49.3 bits (116), Expect = 4e-05
Identities = 37/148 (25%), Positives = 67/148 (45%), Gaps = 8/148 (5%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
++P+ T L+ +VS DS +F TG P P W KD + + KY+++
Sbjct: 26545 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG---GKYKLSEDKGG 26601
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIH----QRWFAKLKRKAA 392
L++++ D+ +Y + +NS G VS S L + + + + Q+ +K A
Sbjct: 26602 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKA 26661
Query: 393 AKLREIEQ-SWKHEKAVPGEVDTLRKLS 419
EI Q + + E+ E + KL+
Sbjct: 26662 VVQEEISQKALRSEEIKMSEAKSQEKLA 26689
Score = 48.1 bits (113), Expect = 8e-05
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E RF C VTGYP+P+V WY + + + ++ + + G H L + C+ D
Sbjct: 1806 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRK---SKRFRVRYDG-IHYLDIVDCKSYDT 1861
Query: 350 AIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
+ +A+N +G++ LE+ +++
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQQREDFR 1890
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/96 (30%), Positives = 41/96 (42%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F L +++ +VRF +T +PEP VTWYK ++ KY
Sbjct: 25382 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG 25441
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ L + +D A Y A+N G SC L V
Sbjct: 25442 LYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
T + P ++S V + RF V P EV WY + EL K T+
Sbjct: 26064 TLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNT 26120
Query: 334 GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV--GTMTEYKIHQR 382
TL++ C +D+ Y+A N KG S L+V G T Y +R
Sbjct: 26121 SGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRR 26171
Score = 43.1 bits (100), Expect = 0.003
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREED 348
++ SD+ V G PEP++ W K D ELD K + + G R T + C D
Sbjct: 22753 TIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL---CEKVSLQYTGKRATAVIKFCDRSD 22809
Query: 349 AAIYQASAQNSKGIVSCSGVLEV 371
+ Y + +N+ G + S +++V
Sbjct: 22810 SGKYTLTVKNASGTKAVSVMVKV 22832
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+S V E S F ++G+P PEV+W++D + LP +I+ R
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-STLPGVQISFSDGRAK 64
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
L + + ++ Y A N G + + L V T
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAET 101
Score = 42.4 bits (98), Expect = 0.004
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 20/293 (6%)
Query: 261 SGRSTFCSIIA--QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+GRS+ I+ + + +P+F LK+ ++ E S + TG P P++ W K+
Sbjct: 1490 AGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1549
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG--IVSCSGVLEV---GT 373
+ + PK I L++ +D+A Y A+A N G C +EV
Sbjct: 1550 IVPH-KYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Query: 374 MTEYK-IHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGA 432
E K I R + K AA +L + + E+ G++ K F++K
Sbjct: 1609 EPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRL 1668
Query: 433 QAPGPS------VPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPEN 486
+ GP+ P +P + W + L +IN F + + ++
Sbjct: 1669 KRFGPAHFECRLTPIGDPT--MVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDS 1726
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRK-PELEKAA 538
G Y D +K+E ++ + E ++GL++ ELE+ A
Sbjct: 1727 GIITCRATNKYGTD--HTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMA 1777
Score = 42.4 bits (98), Expect = 0.004
Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 273 LTEETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
L E P + ++ +S V ++V V G P P V+W KD T L G+ +
Sbjct: 12982 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI---K 13038
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ Q N TL+L+ +D+ Y +A+NS G S + L+V
Sbjct: 13039 MAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 13080
Score = 42.0 bits (97), Expect = 0.006
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E + +F L + VSE ++ C V+ P EV WYK D E+ +YEI +G
Sbjct: 6155 EEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIE---TGRYEILTEGR 6210
Query: 336 RHTLQLYRCREEDAAIYQASAQNSK 360
+ L + EDA Y +S+
Sbjct: 6211 KRILVIQNAHLEDAGNYNCRLPSSR 6235
Score = 41.6 bits (96), Expect = 0.007
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 3/102 (2%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQG 334
E T P+F + + +S + V G P+P++ W+ + L Y+ G
Sbjct: 3645 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSAD---YKFVFDG 3701
Query: 335 NRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
+ H+L + + ED Y A N G CS L++ + E
Sbjct: 3702 DDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGE 3743
Score = 40.8 bits (94), Expect = 0.013
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN-RH 337
P F LK ++ F V G P P VTW+K++ +L C Y I H N
Sbjct: 3767 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQL---CTSVYYTIIHNPNGSG 3823
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
T + + ED+ +Y A+N G +C+ L V
Sbjct: 3824 TFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3857
Score = 40.4 bits (93), Expect = 0.017
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 236 PASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFET-----TLKSRSV 290
P+ + L+S R L +S +G T +++ QL + + ET T+K+ V
Sbjct: 2790 PSDKHRLVSERKVHKLMLQNISPSDAGEYT--AVVGQLECKAKLFVETLHITKTMKNIEV 2847
Query: 291 SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAA 350
E F C V+ + P + W K+ E++ K++I QG H L + ED+A
Sbjct: 2848 PETKTASFECEVSHFNVPSM-WLKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSA 2903
Query: 351 IY 352
Y
Sbjct: 2904 EY 2905
Score = 40.0 bits (92), Expect = 0.022
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E +FE ++S++V + SD F V G P+PE WYK+ +++R + Y + N
Sbjct: 2030 EAPKIFER-IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRI--YWYWPEDN 2086
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED+A A N G S L V
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2122
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 13/124 (10%)
Query: 248 ETSLSSNRLSHPSSGRSTFCSIIAQLTEE--TQPLFETTLKSR--------SVSEDSDVR 297
ET S + H +S ++ + EE T +TTL +R +V E R
Sbjct: 26215 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESAR 26274
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F+C G P P VTW + L ++++T + T ++ + D Y +
Sbjct: 26275 FSCDTDGEPVPTVTWLRKGQVLSTSA---RHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26331
Query: 358 NSKG 361
NS+G
Sbjct: 26332 NSEG 26335
Score = 39.3 bits (90), Expect = 0.037
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 8/95 (8%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEITHQGNR 336
P T L+ SE RF C V+G + +V+WY D ++ R+ + ++E T+Q
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ--- 3354
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L++ ED Y A N+ G VS + L +
Sbjct: 3355 --LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL 3387
Score = 39.3 bits (90), Expect = 0.037
Identities = 35/121 (28%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 1452 EVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTW 1511
E D GK T AK K +A VI++ ++E A G L + + W
Sbjct: 4507 EALNDSGKTATSAKLTVVK---RAAPVIKR-KIEPLEVALGHLAKFTCEIQSAPNVRFQW 4562
Query: 1512 AKDQRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLS 1569
K R + E + + + ++L I++ VDCG Y C NE+GS S L+ V
Sbjct: 4563 FKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPG 4622
Query: 1570 G 1570
G
Sbjct: 4623 G 4623
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCR 345
+ + + +R + I+ G P P+VTW K+D + + ++T G++ L++
Sbjct: 10921 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKA---RIDVTPVGSK--LEIRNAA 10975
Query: 346 EEDAAIYQASAQNSKG 361
ED IY + +N G
Sbjct: 10976 HEDGGIYSLTVENPAG 10991
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
+ +R +V G P P VTW+KD E+++ + EIT +L + +
Sbjct: 21665 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM---EITDVLGSTSLFVRDATRDHR 21721
Query: 350 AIYQASAQNSKG 361
+Y A+N+ G
Sbjct: 21722 GVYTVEAKNASG 21733
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 1476 PQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQR--PVGEVGRSAGDEGPAAL 1533
PQV++++ + SG +C + ++W K+++ G + D L
Sbjct: 3193 PQVLQEL--QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3250
Query: 1534 AIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPM 1588
+++A P D VY C N++G A+T LS EV +E V +TP+
Sbjct: 3251 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Score = 36.2 bits (82), Expect = 0.31
Identities = 36/133 (27%), Positives = 47/133 (35%), Gaps = 30/133 (22%)
Query: 250 SLSSNRLSHPSSGRSTFCSI--IAQLTEETQ-----------PLFETTLKSRSVSEDSDV 296
S+SS + S S+F I + QL T P E S+ E +
Sbjct: 26982 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 27041
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH--------TLQLYRCREED 348
C TG P PEVTW CG K QG H TL + +++D
Sbjct: 27042 TVACAFTGEPTPEVTW---------SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQD 27092
Query: 349 AAIYQASAQNSKG 361
+Y S N G
Sbjct: 27093 GGLYTLSLGNEFG 27105
Score = 35.8 bits (81), Expect = 0.41
Identities = 38/177 (21%), Positives = 71/177 (40%), Gaps = 10/177 (5%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
+ + P+ + ++ V+ +FTC + P W+K E+ K I
Sbjct: 4523 VVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE---SDKCSIRS 4579
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAA 392
+L++ R + D Y A N G VSC+ L V K ++ +RK
Sbjct: 4580 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLP--ERKPE 4637
Query: 393 AKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTL 449
K + +S ++ P E + K+ P + ++ ++ + + P P P E E T+
Sbjct: 4638 PKEEVVLKSVLRKR--PEEEEP--KVEPKKLEKVKKPAVPEPPPPK-PVEEVEVPTV 4689
Score = 35.8 bits (81), Expect = 0.41
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 7/96 (7%)
Query: 275 EETQPLFETTLKSRS----VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR---YCGLPK 327
+E P + L R V V VTG P P++ W K++T +++ + K
Sbjct: 9086 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 9145
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
E++ + L + + ED Y +A N G V
Sbjct: 9146 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSV 9181
Score = 35.4 bits (80), Expect = 0.54
Identities = 28/92 (30%), Positives = 38/92 (41%), Gaps = 5/92 (5%)
Query: 1499 QFFNILSDSV---LTWAKDQRPVGEVGRSAGDEGPAA--LAIVQASPVDCGVYRCTIHNE 1553
QF +L D +TW + + E R + L I VD G+Y C +HN+
Sbjct: 3507 QFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHND 3566
Query: 1554 HGSASTDFCLSPEVLSGFISREEGEVGEEIEM 1585
G +T LS E I E E E+EM
Sbjct: 3567 CGERTTSAVLSVEGAPESILHERIEQEIEMEM 3598
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 281 FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQ 340
F LK +V E RF C++T E V W K D K++I G +H L
Sbjct: 5183 FAVPLKDVTVPERRQARFECVLT--REANVIWSKGP---DIIKSSDKFDIIADGKKHILV 5237
Query: 341 LYRCREEDAAIYQASAQNSK 360
+ + +D +Y A + K
Sbjct: 5238 INDSQFDDEGVYTAEVEGKK 5257
Score = 35.4 bits (80), Expect = 0.54
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 268 SIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPK 327
S+ L E F L+ ++V+E D F+C ++ + V WY++ E+ K
Sbjct: 6507 SVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEG---KK 6562
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
Y+ G+ H L + CR +D Y ++ K
Sbjct: 6563 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRK 6595
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R V G PEP++TW K+ L R + ++ R LQ+ D Y S
Sbjct: 11621 IRILARVKGRPEPDITWTKEGKVLVRE---KRVDLIQDLPRVELQIKEAVRADHGKYIIS 11677
Query: 356 AQNSKGIVSCSGVLEV 371
A+NS G S ++ V
Sbjct: 11678 AKNSSGHAQGSAIVNV 11693
Score = 35.4 bits (80), Expect = 0.54
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1457 EGKQETLAKPRKAKDLLKAPQVIRKI--RVEQFPDASGSLKLWCQFFNILSDSVLTWAKD 1514
+G+ + +P +AKD+L+AP++ + R A +++ F +V TW KD
Sbjct: 20945 QGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV-TWRKD 21003
Query: 1515 QRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
++ +G R + + + L I Q + D G Y TI N G
Sbjct: 21004 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVG 21046
Score = 34.7 bits (78), Expect = 0.92
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
+P + S SV D++ ++G P+P +TW KD L + + +T +
Sbjct: 16924 EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ---TTRINVTDSLDLT 16980
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
TL + ++D Y + N G + S +E+ T+
Sbjct: 16981 TLSIKETHKDDGGQYGITVANVVGQKTAS--IEIVTL 17015
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL-DRYCGLPKYE 329
+QL +P+F S E RF V G P PE W+ D ++ + Y K
Sbjct: 1403 SQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY--THKVV 1460
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
I G + +L + D+ + AQN G S S +L V + E+++ + KLK
Sbjct: 1461 IKEDGTQ-SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV-EHQVKPMFVEKLK 1517
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 3/84 (3%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
QP + + S+ D++ V G P P ++W KD L + + +
Sbjct: 18006 QPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQ---TTRVNVEETATST 18062
Query: 338 TLQLYRCREEDAAIYQASAQNSKG 361
L + ++D Y +A NS G
Sbjct: 18063 VLHIKEGNKDDFGKYTVTATNSAG 18086
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R +VTG P P W K++ ELD+ + I + G + L + +D Y +
Sbjct: 8817 LRIPAVVTGRPVPTKVWTKEEGELDK----DRVVIDNVGTKSELIIKDALRKDHGRYVIT 8872
Query: 356 AQNSKGIVSCSGVLEV 371
A NS G + +EV
Sbjct: 8873 ATNSCGSKFAAARVEV 8888
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDD--TELDRYCGLPKYEITHQGNRHTLQLYRCRE 346
+V +R V G P PEV W KD T+L R P+ +I + + L + +
Sbjct: 11907 TVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTR---SPRVKIDTRADSSKFSLTKAKR 11963
Query: 347 EDAAIYQASAQNSKG 361
D Y +A N+ G
Sbjct: 11964 SDGGKYVVTATNTAG 11978
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 284 TLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYR 343
TLK+ +V+E D FT +T V W K+ L+ KY I+ +G ++L++
Sbjct: 2666 TLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLE---SNEKYAISVKGTIYSLRIKN 2722
Query: 344 CREEDAAIY 352
C D ++Y
Sbjct: 2723 CAIVDESVY 2731
Score = 33.5 bits (75), Expect = 2.0
Identities = 19/72 (26%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + VRF I+ G P P W D +E+ Y + L + C D
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD---EHYTVETDNFSSVLTIKNCLRRDT 11273
Query: 350 AIYQASAQNSKG 361
YQ + N+ G
Sbjct: 11274 GEYQITVSNAAG 11285
Score = 33.5 bits (75), Expect = 2.0
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1511 WAKDQRPVGEVGRS--AGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAST 1559
W KD + + + G+ + D+G L I + D G+Y CT+ N GS S+
Sbjct: 26580 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26630
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/146 (22%), Positives = 58/146 (39%), Gaps = 19/146 (13%)
Query: 252 SSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDV-RFTCIVTGYPEPEV 310
+++ +S PS ST I+ E + + + + V + +V + + G P P +
Sbjct: 19459 AADSVSEPSE--STGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVI 19516
Query: 311 TWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG----IVSC- 365
+W KD E++ + EI N L + C D Y + +N G V+C
Sbjct: 19517 SWAKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19573
Query: 366 --------SGVLEVGTMTEYKIHQRW 383
+G LE+ +T K W
Sbjct: 19574 VLDKPGPPAGPLEINGLTAEKCSLSW 19599
Score = 32.7 bits (73), Expect = 3.5
Identities = 29/98 (29%), Positives = 35/98 (35%), Gaps = 7/98 (7%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD---RYCGLPKYEIT 331
E P F T + + E V F C V G P+P V W K L RY K
Sbjct: 1032 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRY----KVSYN 1087
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
Q L + +DA Y +N G S S L
Sbjct: 1088 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 3.5
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 274 TEETQPLFETT--LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
T+E +F L +V + + VTG PEP++TW K D L + + I
Sbjct: 7379 TQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQD---KRITIE 7435
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
+ + T+ + + D Y A N G + V+EV +
Sbjct: 7436 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCG--RATAVVEVNVL 7476
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 292 EDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAI 351
E+S+ R + G P P V+W K + D + + TL +Y C++ DA
Sbjct: 13691 ENSNFRLKIPIKGKPAPSVSWKKGE---DPLATDTRVSVESSAVNTTLIVYDCQKSDAGK 13747
Query: 352 YQASAQNSKG 361
Y + +N G
Sbjct: 13748 YTITLKNVAG 13757
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1489 DASGSLKLWCQFFNILSDSVLTWAKDQRPV--GEVGRSAGDEGPAALAIVQASPVDCGVY 1546
+ G +K C+ N + +TW R + E ++G A L + + +D G Y
Sbjct: 25275 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25334
Query: 1547 RCTIHNEHGSAST 1559
RC + N++G S+
Sbjct: 25335 RCKVVNDYGEDSS 25347
Score = 32.3 bits (72), Expect = 4.5
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 304 GYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
G P PE+TW +++ E K +I N L + C DA Y +NS G
Sbjct: 17745 GRPTPEITWSREEGEF-----TDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 17799
Query: 364 SCSGVLEV 371
S ++V
Sbjct: 17800 SAFVTVKV 17807
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/83 (25%), Positives = 31/83 (37%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F+ + +V D++ G P P VTW+KD+ L + + N
Sbjct: 15843 PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQ---TTRVNAESTENNSL 15899
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + ED Y NS G
Sbjct: 15900 LTIKDACREDVGHYVVKLTNSAG 15922
Score = 32.0 bits (71), Expect = 5.9
Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 8/99 (8%)
Query: 276 ETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
E +PLF+ + R V + T G P P V W K DT+L + +
Sbjct: 19876 EEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL-----RTRAYVDT 19930
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+R +L + D+ Y + QN S + V++V
Sbjct: 19931 TDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 19969
Score = 31.6 bits (70), Expect = 7.7
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + +R G P P W K D+ L + +I + TL + C DA
Sbjct: 22064 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL-----RADIHTTDSFSTLTVENCNRNDA 22118
Query: 350 AIYQASAQNSKGIVSCSGVLEV 371
Y + +N+ G S + ++V
Sbjct: 22119 GKYTLTVENNSGSKSITFTVKV 22140
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 60.1 bits (144), Expect = 2e-08
Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 9/141 (6%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
T P + LK+ +V E V C ++GYP P VTWY++D +++ ++IT Q
Sbjct: 895 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI---DFQITFQSGI 951
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK-----IHQRWFAKLKRKA 391
L + ED+ + SA N G VS S L V E++ + +++ + KR
Sbjct: 952 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFV 1011
Query: 392 AAK-LREIEQSWKHEKAVPGE 411
++ + + S E+A PGE
Sbjct: 1012 ESRDVVMTDTSLTEEQAGPGE 1032
Score = 57.8 bits (138), Expect = 1e-07
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
Q+ +E QP+ +V RF +++G P+P+++WYK++ L K +
Sbjct: 3194 QVLQELQPV--------TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF---KCKFL 3242
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
H G +TL L EDAA+Y A+N G+ + S L V
Sbjct: 3243 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 3282
Score = 55.8 bits (133), Expect = 4e-07
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH- 332
+E + F++ +K+ + E V F C ++GYP P++ WYKD + +Y++
Sbjct: 1240 SEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG---ERYQMDFL 1296
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Q R +L++ ED IY A A N KG CSG L V
Sbjct: 1297 QDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1335
Score = 55.5 bits (132), Expect = 5e-07
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Query: 262 GRSTFCSIIAQLTEETQ-----PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
G S + I +T ++ P F+ L++ +V S+ C VTG+P+P V WY+
Sbjct: 24534 GESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQG 24593
Query: 317 TELDRYCGLPKYEITH-QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ GL KY I +G H L + ++DA +YQ A N G VS + LEV
Sbjct: 24594 KEIIA-DGL-KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24647
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 243 LSVRPETSLSSNRLSHPS---SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFT 299
L++ T +S R S + SG++T + + E P F L+S +V + S VR
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
VTG P P V +Y+D E+ ++I+ +G+ ++L + ED+ Y +A NS
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSL---DFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 360 KGIVSCSGVLEV 371
G + + L V
Sbjct: 182 VGRATSTAELLV 193
Score = 51.6 bits (122), Expect = 7e-06
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 249 TSLSSNRLSHPSSGRSTFCSIIAQLTEET-QPLFETTLKSRSVSEDSDVRFTCIVTGYPE 307
T ++ N+ S ++ T+ T +P+F+ L + E V F V+G P
Sbjct: 25392 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPP 25451
Query: 308 PEVTWYKDDTELDRYCGLPKYEITHQG-NRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
P + W KD L P EI H+G + + L + ED Y+ +A N+ G SC
Sbjct: 25452 PTLKWEKDGQPLSLG---PNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 25508
Query: 367 GVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVD-TLR 416
L+V + K +E + +HE+ V ++D TLR
Sbjct: 25509 AHLQV-----------------ERLRYKKQEFKSKEEHERHVQKQIDKTLR 25542
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
S R T SI +LT P +K + + +C + G P P++ WY+ EL
Sbjct: 24142 SRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL 24201
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
+ KY+++ G HTL + +ED +Y A N G V S L
Sbjct: 24202 IQ---SRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24248
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F + +S++++E +V FTC ++G P PE+ W+K++ + + I+ N ++
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNV---SISRSRNVYS 26818
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
L++ D+ Y A+N +G S + L V + E
Sbjct: 26819 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVE 26856
Score = 49.3 bits (116), Expect = 4e-05
Identities = 37/148 (25%), Positives = 67/148 (45%), Gaps = 8/148 (5%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
++P+ T L+ +VS DS +F TG P P W KD + + KY+++
Sbjct: 26478 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG---GKYKLSEDKGG 26534
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIH----QRWFAKLKRKAA 392
L++++ D+ +Y + +NS G VS S L + + + + Q+ +K A
Sbjct: 26535 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKA 26594
Query: 393 AKLREIEQ-SWKHEKAVPGEVDTLRKLS 419
EI Q + + E+ E + KL+
Sbjct: 26595 VVQEEISQKALRSEEIKMSEAKSQEKLA 26622
Score = 48.1 bits (113), Expect = 8e-05
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E RF C VTGYP+P+V WY + + + ++ + + G H L + C+ D
Sbjct: 1806 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRK---SKRFRVRYDG-IHYLDIVDCKSYDT 1861
Query: 350 AIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
+ +A+N +G++ LE+ +++
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQQREDFR 1890
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/96 (30%), Positives = 41/96 (42%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F L +++ +VRF +T +PEP VTWYK ++ KY
Sbjct: 25315 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG 25374
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ L + +D A Y A+N G SC L V
Sbjct: 25375 LYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
T + P ++S V + RF V P EV WY + EL K T+
Sbjct: 25997 TLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNT 26053
Query: 334 GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV--GTMTEYKIHQR 382
TL++ C +D+ Y+A N KG S L+V G T Y +R
Sbjct: 26054 SGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRR 26104
Score = 43.1 bits (100), Expect = 0.003
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREED 348
++ SD+ V G PEP++ W K D ELD K + + G R T + C D
Sbjct: 22686 TIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL---CEKVSLQYTGKRATAVIKFCDRSD 22742
Query: 349 AAIYQASAQNSKGIVSCSGVLEV 371
+ Y + +N+ G + S +++V
Sbjct: 22743 SGKYTLTVKNASGTKAVSVMVKV 22765
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+S V E S F ++G+P PEV+W++D + LP +I+ R
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-STLPGVQISFSDGRAK 64
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
L + + ++ Y A N G + + L V T
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAET 101
Score = 42.4 bits (98), Expect = 0.004
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 20/293 (6%)
Query: 261 SGRSTFCSIIA--QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+GRS+ I+ + + +P+F LK+ ++ E S + TG P P++ W K+
Sbjct: 1490 AGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1549
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG--IVSCSGVLEV---GT 373
+ + PK I L++ +D+A Y A+A N G C +EV
Sbjct: 1550 IVPH-KYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Query: 374 MTEYK-IHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGA 432
E K I R + K AA +L + + E+ G++ K F++K
Sbjct: 1609 EPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRL 1668
Query: 433 QAPGPS------VPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPEN 486
+ GP+ P +P + W + L +IN F + + ++
Sbjct: 1669 KRFGPAHFECRLTPIGDPT--MVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDS 1726
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRK-PELEKAA 538
G Y D +K+E ++ + E ++GL++ ELE+ A
Sbjct: 1727 GIITCRATNKYGTD--HTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMA 1777
Score = 42.4 bits (98), Expect = 0.004
Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 273 LTEETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
L E P + ++ +S V ++V V G P P V+W KD T L G+ +
Sbjct: 12915 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI---K 12971
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ Q N TL+L+ +D+ Y +A+NS G S + L+V
Sbjct: 12972 MAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 13013
Score = 42.0 bits (97), Expect = 0.006
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E + +F L + VSE ++ C V+ P EV WYK D E+ +YEI +G
Sbjct: 6088 EEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIE---TGRYEILTEGR 6143
Query: 336 RHTLQLYRCREEDAAIYQASAQNSK 360
+ L + EDA Y +S+
Sbjct: 6144 KRILVIQNAHLEDAGNYNCRLPSSR 6168
Score = 41.6 bits (96), Expect = 0.007
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 3/102 (2%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQG 334
E T P+F + + +S + V G P+P++ W+ + L Y+ G
Sbjct: 3578 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSAD---YKFVFDG 3634
Query: 335 NRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
+ H+L + + ED Y A N G CS L++ + E
Sbjct: 3635 DDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGE 3676
Score = 40.8 bits (94), Expect = 0.013
Identities = 32/130 (24%), Positives = 55/130 (42%), Gaps = 14/130 (10%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
+P F L S V VRF V+G P+PE+ W+ + + LP ++
Sbjct: 3418 KPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLI-----LPTKDVVFHFEES 3472
Query: 338 T----LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT-EYKIHQRWFAKLKRKAA 392
T + + E A Y A NS G +C+ L V E +H+R ++++
Sbjct: 3473 TGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHER----IEQEIE 3528
Query: 393 AKLREIEQSW 402
+++E S+
Sbjct: 3529 MEMKEFSSSF 3538
Score = 40.8 bits (94), Expect = 0.013
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN-RH 337
P F LK ++ F V G P P VTW+K++ +L C Y I H N
Sbjct: 3700 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQL---CTSVYYTIIHNPNGSG 3756
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
T + + ED+ +Y A+N G +C+ L V
Sbjct: 3757 TFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790
Score = 40.4 bits (93), Expect = 0.017
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 236 PASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFET-----TLKSRSV 290
P+ + L+S R L +S +G T +++ QL + + ET T+K+ V
Sbjct: 2790 PSDKHRLVSERKVHKLMLQNISPSDAGEYT--AVVGQLECKAKLFVETLHITKTMKNIEV 2847
Query: 291 SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAA 350
E F C V+ + P + W K+ E++ K++I QG H L + ED+A
Sbjct: 2848 PETKTASFECEVSHFNVPSM-WLKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSA 2903
Query: 351 IY 352
Y
Sbjct: 2904 EY 2905
Score = 40.0 bits (92), Expect = 0.022
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E +FE ++S++V + SD F V G P+PE WYK+ +++R + Y + N
Sbjct: 2030 EAPKIFER-IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRI--YWYWPEDN 2086
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED+A A N G S L V
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2122
Score = 40.0 bits (92), Expect = 0.022
Identities = 28/102 (27%), Positives = 49/102 (48%), Gaps = 8/102 (7%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEITHQGNR 336
P T L+ SE RF C V+G + +V+WY D ++ R+ + ++E T+Q
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ--- 3354
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
L++ ED Y A N+ G VS + L + ++++
Sbjct: 3355 --LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEGFSKFE 3394
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 13/124 (10%)
Query: 248 ETSLSSNRLSHPSSGRSTFCSIIAQLTEE--TQPLFETTLKSR--------SVSEDSDVR 297
ET S + H +S ++ + EE T +TTL +R +V E R
Sbjct: 26148 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESAR 26207
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F+C G P P VTW + L ++++T + T ++ + D Y +
Sbjct: 26208 FSCDTDGEPVPTVTWLRKGQVLSTSA---RHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26264
Query: 358 NSKG 361
NS+G
Sbjct: 26265 NSEG 26268
Score = 39.3 bits (90), Expect = 0.037
Identities = 35/121 (28%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 1452 EVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTW 1511
E D GK T AK K +A VI++ ++E A G L + + W
Sbjct: 4440 EALNDSGKTATSAKLTVVK---RAAPVIKR-KIEPLEVALGHLAKFTCEIQSAPNVRFQW 4495
Query: 1512 AKDQRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLS 1569
K R + E + + + ++L I++ VDCG Y C NE+GS S L+ V
Sbjct: 4496 FKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPG 4555
Query: 1570 G 1570
G
Sbjct: 4556 G 4556
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCR 345
+ + + +R + I+ G P P+VTW K+D + + ++T G++ L++
Sbjct: 10854 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKA---RIDVTPVGSK--LEIRNAA 10908
Query: 346 EEDAAIYQASAQNSKG 361
ED IY + +N G
Sbjct: 10909 HEDGGIYSLTVENPAG 10924
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
+ +R +V G P P VTW+KD E+++ + EIT +L + +
Sbjct: 21598 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM---EITDVLGSTSLFVRDATRDHR 21654
Query: 350 AIYQASAQNSKG 361
+Y A+N+ G
Sbjct: 21655 GVYTVEAKNASG 21666
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 1476 PQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQR--PVGEVGRSAGDEGPAAL 1533
PQV++++ + SG +C + ++W K+++ G + D L
Sbjct: 3193 PQVLQEL--QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3250
Query: 1534 AIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPM 1588
+++A P D VY C N++G A+T LS EV +E V +TP+
Sbjct: 3251 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Score = 36.2 bits (82), Expect = 0.31
Identities = 36/133 (27%), Positives = 47/133 (35%), Gaps = 30/133 (22%)
Query: 250 SLSSNRLSHPSSGRSTFCSI--IAQLTEETQ-----------PLFETTLKSRSVSEDSDV 296
S+SS + S S+F I + QL T P E S+ E +
Sbjct: 26915 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 26974
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH--------TLQLYRCREED 348
C TG P PEVTW CG K QG H TL + +++D
Sbjct: 26975 TVACAFTGEPTPEVTW---------SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQD 27025
Query: 349 AAIYQASAQNSKG 361
+Y S N G
Sbjct: 27026 GGLYTLSLGNEFG 27038
Score = 35.8 bits (81), Expect = 0.41
Identities = 38/177 (21%), Positives = 71/177 (40%), Gaps = 10/177 (5%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
+ + P+ + ++ V+ +FTC + P W+K E+ K I
Sbjct: 4456 VVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE---SDKCSIRS 4512
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAA 392
+L++ R + D Y A N G VSC+ L V K ++ +RK
Sbjct: 4513 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLP--ERKPE 4570
Query: 393 AKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTL 449
K + +S ++ P E + K+ P + ++ ++ + + P P P E E T+
Sbjct: 4571 PKEEVVLKSVLRKR--PEEEEP--KVEPKKLEKVKKPAVPEPPPPK-PVEEVEVPTV 4622
Score = 35.8 bits (81), Expect = 0.41
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 7/96 (7%)
Query: 275 EETQPLFETTLKSRS----VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR---YCGLPK 327
+E P + L R V V VTG P P++ W K++T +++ + K
Sbjct: 9019 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 9078
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
E++ + L + + ED Y +A N G V
Sbjct: 9079 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSV 9114
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 281 FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQ 340
F LK +V E RF C++T E V W K D K++I G +H L
Sbjct: 5116 FAVPLKDVTVPERRQARFECVLT--REANVIWSKGP---DIIKSSDKFDIIADGKKHILV 5170
Query: 341 LYRCREEDAAIYQASAQNSK 360
+ + +D +Y A + K
Sbjct: 5171 INDSQFDDEGVYTAEVEGKK 5190
Score = 35.4 bits (80), Expect = 0.54
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 268 SIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPK 327
S+ L E F L+ ++V+E D F+C ++ + V WY++ E+ K
Sbjct: 6440 SVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEG---KK 6495
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
Y+ G+ H L + CR +D Y ++ K
Sbjct: 6496 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRK 6528
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R V G PEP++TW K+ L R + ++ R LQ+ D Y S
Sbjct: 11554 IRILARVKGRPEPDITWTKEGKVLVRE---KRVDLIQDLPRVELQIKEAVRADHGKYIIS 11610
Query: 356 AQNSKGIVSCSGVLEV 371
A+NS G S ++ V
Sbjct: 11611 AKNSSGHAQGSAIVNV 11626
Score = 35.4 bits (80), Expect = 0.54
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1457 EGKQETLAKPRKAKDLLKAPQVIRKI--RVEQFPDASGSLKLWCQFFNILSDSVLTWAKD 1514
+G+ + +P +AKD+L+AP++ + R A +++ F +V TW KD
Sbjct: 20878 QGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV-TWRKD 20936
Query: 1515 QRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
++ +G R + + + L I Q + D G Y TI N G
Sbjct: 20937 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVG 20979
Score = 34.7 bits (78), Expect = 0.92
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
+P + S SV D++ ++G P+P +TW KD L + + +T +
Sbjct: 16857 EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ---TTRINVTDSLDLT 16913
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
TL + ++D Y + N G + S +E+ T+
Sbjct: 16914 TLSIKETHKDDGGQYGITVANVVGQKTAS--IEIVTL 16948
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL-DRYCGLPKYE 329
+QL +P+F S E RF V G P PE W+ D ++ + Y K
Sbjct: 1403 SQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY--THKVV 1460
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
I G + +L + D+ + AQN G S S +L V + E+++ + KLK
Sbjct: 1461 IKEDGTQ-SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV-EHQVKPMFVEKLK 1517
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 3/84 (3%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
QP + + S+ D++ V G P P ++W KD L + + +
Sbjct: 17939 QPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQ---TTRVNVEETATST 17995
Query: 338 TLQLYRCREEDAAIYQASAQNSKG 361
L + ++D Y +A NS G
Sbjct: 17996 VLHIKEGNKDDFGKYTVTATNSAG 18019
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R +VTG P P W K++ ELD+ + I + G + L + +D Y +
Sbjct: 8750 LRIPAVVTGRPVPTKVWTKEEGELDK----DRVVIDNVGTKSELIIKDALRKDHGRYVIT 8805
Query: 356 AQNSKGIVSCSGVLEV 371
A NS G + +EV
Sbjct: 8806 ATNSCGSKFAAARVEV 8821
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDD--TELDRYCGLPKYEITHQGNRHTLQLYRCRE 346
+V +R V G P PEV W KD T+L R P+ +I + + L + +
Sbjct: 11840 TVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTR---SPRVKIDTRADSSKFSLTKAKR 11896
Query: 347 EDAAIYQASAQNSKG 361
D Y +A N+ G
Sbjct: 11897 SDGGKYVVTATNTAG 11911
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 284 TLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYR 343
TLK+ +V+E D FT +T V W K+ L+ KY I+ +G ++L++
Sbjct: 2666 TLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLE---SNEKYAISVKGTIYSLRIKN 2722
Query: 344 CREEDAAIY 352
C D ++Y
Sbjct: 2723 CAIVDESVY 2731
Score = 33.5 bits (75), Expect = 2.0
Identities = 19/72 (26%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + VRF I+ G P P W D +E+ Y + L + C D
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD---EHYTVETDNFSSVLTIKNCLRRDT 11206
Query: 350 AIYQASAQNSKG 361
YQ + N+ G
Sbjct: 11207 GEYQITVSNAAG 11218
Score = 33.5 bits (75), Expect = 2.0
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1511 WAKDQRPVGEVGRS--AGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAST 1559
W KD + + + G+ + D+G L I + D G+Y CT+ N GS S+
Sbjct: 26513 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26563
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/146 (22%), Positives = 58/146 (39%), Gaps = 19/146 (13%)
Query: 252 SSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDV-RFTCIVTGYPEPEV 310
+++ +S PS ST I+ E + + + + V + +V + + G P P +
Sbjct: 19392 AADSVSEPSE--STGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVI 19449
Query: 311 TWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG----IVSC- 365
+W KD E++ + EI N L + C D Y + +N G V+C
Sbjct: 19450 SWAKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19506
Query: 366 --------SGVLEVGTMTEYKIHQRW 383
+G LE+ +T K W
Sbjct: 19507 VLDKPGPPAGPLEINGLTAEKCSLSW 19532
Score = 32.7 bits (73), Expect = 3.5
Identities = 29/98 (29%), Positives = 35/98 (35%), Gaps = 7/98 (7%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD---RYCGLPKYEIT 331
E P F T + + E V F C V G P+P V W K L RY K
Sbjct: 1032 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRY----KVSYN 1087
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
Q L + +DA Y +N G S S L
Sbjct: 1088 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 3.5
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 274 TEETQPLFETT--LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
T+E +F L +V + + VTG PEP++TW K D L + + I
Sbjct: 7312 TQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQD---KRITIE 7368
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
+ + T+ + + D Y A N G + V+EV +
Sbjct: 7369 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCG--RATAVVEVNVL 7409
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 292 EDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAI 351
E+S+ R + G P P V+W K + D + + TL +Y C++ DA
Sbjct: 13624 ENSNFRLKIPIKGKPAPSVSWKKGE---DPLATDTRVSVESSAVNTTLIVYDCQKSDAGK 13680
Query: 352 YQASAQNSKG 361
Y + +N G
Sbjct: 13681 YTITLKNVAG 13690
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1489 DASGSLKLWCQFFNILSDSVLTWAKDQRPV--GEVGRSAGDEGPAALAIVQASPVDCGVY 1546
+ G +K C+ N + +TW R + E ++G A L + + +D G Y
Sbjct: 25208 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25267
Query: 1547 RCTIHNEHGSAST 1559
RC + N++G S+
Sbjct: 25268 RCKVVNDYGEDSS 25280
Score = 32.3 bits (72), Expect = 4.5
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 304 GYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
G P PE+TW +++ E K +I N L + C DA Y +NS G
Sbjct: 17678 GRPTPEITWSREEGEF-----TDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 17732
Query: 364 SCSGVLEV 371
S ++V
Sbjct: 17733 SAFVTVKV 17740
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/83 (25%), Positives = 31/83 (37%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F+ + +V D++ G P P VTW+KD+ L + + N
Sbjct: 15776 PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQ---TTRVNAESTENNSL 15832
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + ED Y NS G
Sbjct: 15833 LTIKDACREDVGHYVVKLTNSAG 15855
Score = 32.0 bits (71), Expect = 5.9
Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 8/99 (8%)
Query: 276 ETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
E +PLF+ + R V + T G P P V W K DT+L + +
Sbjct: 19809 EEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL-----RTRAYVDT 19863
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+R +L + D+ Y + QN S + V++V
Sbjct: 19864 TDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 19902
Score = 31.6 bits (70), Expect = 7.7
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + +R G P P W K D+ L + +I + TL + C DA
Sbjct: 21997 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL-----RADIHTTDSFSTLTVENCNRNDA 22051
Query: 350 AIYQASAQNSKGIVSCSGVLEV 371
Y + +N+ G S + ++V
Sbjct: 22052 GKYTLTVENNSGSKSITFTVKV 22073
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 60.1 bits (144), Expect = 2e-08
Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 9/141 (6%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
T P + LK+ +V E V C ++GYP P VTWY++D +++ ++IT Q
Sbjct: 895 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI---DFQITFQSGI 951
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYK-----IHQRWFAKLKRKA 391
L + ED+ + SA N G VS S L V E++ + +++ + KR
Sbjct: 952 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFV 1011
Query: 392 AAK-LREIEQSWKHEKAVPGE 411
++ + + S E+A PGE
Sbjct: 1012 ESRDVVMTDTSLTEEQAGPGE 1032
Score = 57.8 bits (138), Expect = 1e-07
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 11/100 (11%)
Query: 272 QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
Q+ +E QP+ +V RF +++G P+P+++WYK++ L K +
Sbjct: 3194 QVLQELQPV--------TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF---KCKFL 3242
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
H G +TL L EDAA+Y A+N G+ + S L V
Sbjct: 3243 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 3282
Score = 55.8 bits (133), Expect = 4e-07
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH- 332
+E + F++ +K+ + E V F C ++GYP P++ WYKD + +Y++
Sbjct: 1240 SEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHG---ERYQMDFL 1296
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
Q R +L++ ED IY A A N KG CSG L V
Sbjct: 1297 QDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1335
Score = 55.5 bits (132), Expect = 5e-07
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Query: 262 GRSTFCSIIAQLTEETQ-----PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDD 316
G S + I +T ++ P F+ L++ +V S+ C VTG+P+P V WY+
Sbjct: 24409 GESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQG 24468
Query: 317 TELDRYCGLPKYEITH-QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
E+ GL KY I +G H L + ++DA +YQ A N G VS + LEV
Sbjct: 24469 KEIIA-DGL-KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24522
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 243 LSVRPETSLSSNRLSHPS---SGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFT 299
L++ T +S R S + SG++T + + E P F L+S +V + S VR
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 300 CIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNS 359
VTG P P V +Y+D E+ ++I+ +G+ ++L + ED+ Y +A NS
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSL---DFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 360 KGIVSCSGVLEV 371
G + + L V
Sbjct: 182 VGRATSTAELLV 193
Score = 51.6 bits (122), Expect = 7e-06
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 249 TSLSSNRLSHPSSGRSTFCSIIAQLTEET-QPLFETTLKSRSVSEDSDVRFTCIVTGYPE 307
T ++ N+ S ++ T+ T +P+F+ L + E V F V+G P
Sbjct: 25267 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPP 25326
Query: 308 PEVTWYKDDTELDRYCGLPKYEITHQG-NRHTLQLYRCREEDAAIYQASAQNSKGIVSCS 366
P + W KD L P EI H+G + + L + ED Y+ +A N+ G SC
Sbjct: 25327 PTLKWEKDGQPLSLG---PNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 25383
Query: 367 GVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVD-TLR 416
L+V + K +E + +HE+ V ++D TLR
Sbjct: 25384 AHLQV-----------------ERLRYKKQEFKSKEEHERHVQKQIDKTLR 25417
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL 319
S R T SI +LT P +K + + +C + G P P++ WY+ EL
Sbjct: 24017 SRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKEL 24076
Query: 320 DRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
+ KY+++ G HTL + +ED +Y A N G V S L
Sbjct: 24077 IQ---SRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24123
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F + +S++++E +V FTC ++G P PE+ W+K++ + + I+ N ++
Sbjct: 26637 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNV---SISRSRNVYS 26693
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
L++ D+ Y A+N +G S + L V + E
Sbjct: 26694 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVE 26731
Score = 49.3 bits (116), Expect = 4e-05
Identities = 37/148 (25%), Positives = 67/148 (45%), Gaps = 8/148 (5%)
Query: 277 TQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNR 336
++P+ T L+ +VS DS +F TG P P W KD + + KY+++
Sbjct: 26353 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG---GKYKLSEDKGG 26409
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIH----QRWFAKLKRKAA 392
L++++ D+ +Y + +NS G VS S L + + + + Q+ +K A
Sbjct: 26410 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKA 26469
Query: 393 AKLREIEQ-SWKHEKAVPGEVDTLRKLS 419
EI Q + + E+ E + KL+
Sbjct: 26470 VVQEEISQKALRSEEIKMSEAKSQEKLA 26497
Score = 48.1 bits (113), Expect = 8e-05
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E RF C VTGYP+P+V WY + + + ++ + + G H L + C+ D
Sbjct: 1806 VLEGETARFRCRVTGYPQPKVNWYLNGQLIRK---SKRFRVRYDG-IHYLDIVDCKSYDT 1861
Query: 350 AIYQASAQNSKGIVSCSGVLEVGTMTEYK 378
+ +A+N +G++ LE+ +++
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQQREDFR 1890
Score = 47.4 bits (111), Expect = 1e-04
Identities = 29/96 (30%), Positives = 41/96 (42%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F L +++ +VRF +T +PEP VTWYK ++ KY
Sbjct: 25190 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG 25249
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ L + +D A Y A+N G SC L V
Sbjct: 25250 LYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25285
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 274 TEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQ 333
T + P ++S V + RF V P EV WY + EL K T+
Sbjct: 25872 TLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNT 25928
Query: 334 GNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV--GTMTEYKIHQR 382
TL++ C +D+ Y+A N KG S L+V G T Y +R
Sbjct: 25929 SGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRR 25979
Score = 43.1 bits (100), Expect = 0.003
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREED 348
++ SD+ V G PEP++ W K D ELD K + + G R T + C D
Sbjct: 22561 TIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL---CEKVSLQYTGKRATAVIKFCDRSD 22617
Query: 349 AAIYQASAQNSKGIVSCSGVLEV 371
+ Y + +N+ G + S +++V
Sbjct: 22618 SGKYTLTVKNASGTKAVSVMVKV 22640
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+S V E S F ++G+P PEV+W++D + LP +I+ R
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIST-STLPGVQISFSDGRAK 64
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMT 375
L + + ++ Y A N G + + L V T
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAET 101
Score = 42.4 bits (98), Expect = 0.004
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 20/293 (6%)
Query: 261 SGRSTFCSIIA--QLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+GRS+ I+ + + +P+F LK+ ++ E S + TG P P++ W K+
Sbjct: 1490 AGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1549
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG--IVSCSGVLEV---GT 373
+ + PK I L++ +D+A Y A+A N G C +EV
Sbjct: 1550 IVPH-KYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Query: 374 MTEYK-IHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGA 432
E K I R + K AA +L + + E+ G++ K F++K
Sbjct: 1609 EPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRL 1668
Query: 433 QAPGPS------VPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPEN 486
+ GP+ P +P + W + L +IN F + + ++
Sbjct: 1669 KRFGPAHFECRLTPIGDPT--MVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDS 1726
Query: 487 GEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRK-PELEKAA 538
G Y D +K+E ++ + E ++GL++ ELE+ A
Sbjct: 1727 GIITCRATNKYGTD--HTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMA 1777
Score = 42.4 bits (98), Expect = 0.004
Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 273 LTEETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYE 329
L E P + ++ +S V ++V V G P P V+W KD T L G+ +
Sbjct: 12790 LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI---K 12846
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+ Q N TL+L+ +D+ Y +A+NS G S + L+V
Sbjct: 12847 MAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 12888
Score = 42.0 bits (97), Expect = 0.006
Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E + +F L + VSE ++ C V+ P EV WYK D E+ +YEI +G
Sbjct: 5963 EEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIE---TGRYEILTEGR 6018
Query: 336 RHTLQLYRCREEDAAIYQASAQNSK 360
+ L + EDA Y +S+
Sbjct: 6019 KRILVIQNAHLEDAGNYNCRLPSSR 6043
Score = 41.6 bits (96), Expect = 0.007
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 3/102 (2%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQG 334
E T P+F + + +S + V G P+P++ W+ + L Y+ G
Sbjct: 3453 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSAD---YKFVFDG 3509
Query: 335 NRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTE 376
+ H+L + + ED Y A N G CS L++ + E
Sbjct: 3510 DDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGE 3551
Score = 40.8 bits (94), Expect = 0.013
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 13/126 (10%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL--DRYCGLPKYEITHQGNR 336
P T L+ SE RF C V+G + +V+WY D ++ R+ + ++E T+Q
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ--- 3354
Query: 337 HTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLR 396
L++ ED Y A N+ G VS + L + E +H+R ++++ +++
Sbjct: 3355 --LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL-EAPESILHER----IEQEIEMEMK 3407
Query: 397 EIEQSW 402
E S+
Sbjct: 3408 EFSSSF 3413
Score = 40.8 bits (94), Expect = 0.013
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN-RH 337
P F LK ++ F V G P P VTW+K++ +L C Y I H N
Sbjct: 3575 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQL---CTSVYYTIIHNPNGSG 3631
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
T + + ED+ +Y A+N G +C+ L V
Sbjct: 3632 TFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 40.4 bits (93), Expect = 0.017
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 236 PASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFET-----TLKSRSV 290
P+ + L+S R L +S +G T +++ QL + + ET T+K+ V
Sbjct: 2790 PSDKHRLVSERKVHKLMLQNISPSDAGEYT--AVVGQLECKAKLFVETLHITKTMKNIEV 2847
Query: 291 SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAA 350
E F C V+ + P + W K+ E++ K++I QG H L + ED+A
Sbjct: 2848 PETKTASFECEVSHFNVPSM-WLKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSA 2903
Query: 351 IY 352
Y
Sbjct: 2904 EY 2905
Score = 40.0 bits (92), Expect = 0.022
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E +FE ++S++V + SD F V G P+PE WYK+ +++R + Y + N
Sbjct: 2030 EAPKIFER-IQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRI--YWYWPEDN 2086
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + ED+A A N G S L V
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLV 2122
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 13/124 (10%)
Query: 248 ETSLSSNRLSHPSSGRSTFCSIIAQLTEE--TQPLFETTLKSR--------SVSEDSDVR 297
ET S + H +S ++ + EE T +TTL +R +V E R
Sbjct: 26023 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESAR 26082
Query: 298 FTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQ 357
F+C G P P VTW + L ++++T + T ++ + D Y +
Sbjct: 26083 FSCDTDGEPVPTVTWLRKGQVLSTSA---RHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26139
Query: 358 NSKG 361
NS+G
Sbjct: 26140 NSEG 26143
Score = 39.3 bits (90), Expect = 0.037
Identities = 35/121 (28%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 1452 EVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTW 1511
E D GK T AK K +A VI++ ++E A G L + + W
Sbjct: 4315 EALNDSGKTATSAKLTVVK---RAAPVIKR-KIEPLEVALGHLAKFTCEIQSAPNVRFQW 4370
Query: 1512 AKDQRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLS 1569
K R + E + + + ++L I++ VDCG Y C NE+GS S L+ V
Sbjct: 4371 FKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPG 4430
Query: 1570 G 1570
G
Sbjct: 4431 G 4431
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 286 KSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCR 345
+ + + +R + I+ G P P+VTW K+D + + ++T G++ L++
Sbjct: 10729 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKA---RIDVTPVGSK--LEIRNAA 10783
Query: 346 EEDAAIYQASAQNSKG 361
ED IY + +N G
Sbjct: 10784 HEDGGIYSLTVENPAG 10799
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
+ +R +V G P P VTW+KD E+++ + EIT +L + +
Sbjct: 21473 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM---EITDVLGSTSLFVRDATRDHR 21529
Query: 350 AIYQASAQNSKG 361
+Y A+N+ G
Sbjct: 21530 GVYTVEAKNASG 21541
Score = 37.4 bits (85), Expect = 0.14
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 4/115 (3%)
Query: 1476 PQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQR--PVGEVGRSAGDEGPAAL 1533
PQV++++ + SG +C + ++W K+++ G + D L
Sbjct: 3193 PQVLQEL--QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3250
Query: 1534 AIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPM 1588
+++A P D VY C N++G A+T LS EV +E V +TP+
Sbjct: 3251 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Score = 36.2 bits (82), Expect = 0.31
Identities = 36/133 (27%), Positives = 47/133 (35%), Gaps = 30/133 (22%)
Query: 250 SLSSNRLSHPSSGRSTFCSI--IAQLTEETQ-----------PLFETTLKSRSVSEDSDV 296
S+SS + S S+F I + QL T P E S+ E +
Sbjct: 26790 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 26849
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH--------TLQLYRCREED 348
C TG P PEVTW CG K QG H TL + +++D
Sbjct: 26850 TVACAFTGEPTPEVTW---------SCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQD 26900
Query: 349 AAIYQASAQNSKG 361
+Y S N G
Sbjct: 26901 GGLYTLSLGNEFG 26913
Score = 35.8 bits (81), Expect = 0.41
Identities = 38/177 (21%), Positives = 71/177 (40%), Gaps = 10/177 (5%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
+ + P+ + ++ V+ +FTC + P W+K E+ K I
Sbjct: 4331 VVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE---SDKCSIRS 4387
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAA 392
+L++ R + D Y A N G VSC+ L V K ++ +RK
Sbjct: 4388 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLP--ERKPE 4445
Query: 393 AKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTL 449
K + +S ++ P E + K+ P + ++ ++ + + P P P E E T+
Sbjct: 4446 PKEEVVLKSVLRKR--PEEEEP--KVEPKKLEKVKKPAVPEPPPPK-PVEEVEVPTV 4497
Score = 35.8 bits (81), Expect = 0.41
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 7/96 (7%)
Query: 275 EETQPLFETTLKSRS----VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDR---YCGLPK 327
+E P + L R V V VTG P P++ W K++T +++ + K
Sbjct: 8894 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITK 8953
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
E++ + L + + ED Y +A N G V
Sbjct: 8954 EEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSV 8989
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 5/80 (6%)
Query: 281 FETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQ 340
F LK +V E RF C++T E V W K D K++I G +H L
Sbjct: 4991 FAVPLKDVTVPERRQARFECVLT--REANVIWSKGP---DIIKSSDKFDIIADGKKHILV 5045
Query: 341 LYRCREEDAAIYQASAQNSK 360
+ + +D +Y A + K
Sbjct: 5046 INDSQFDDEGVYTAEVEGKK 5065
Score = 35.4 bits (80), Expect = 0.54
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 268 SIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPK 327
S+ L E F L+ ++V+E D F+C ++ + V WY++ E+ K
Sbjct: 6315 SVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEG---KK 6370
Query: 328 YEITHQGNRHTLQLYRCREEDAAIYQASAQNSK 360
Y+ G+ H L + CR +D Y ++ K
Sbjct: 6371 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRK 6403
Score = 35.4 bits (80), Expect = 0.54
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R V G PEP++TW K+ L R + ++ R LQ+ D Y S
Sbjct: 11429 IRILARVKGRPEPDITWTKEGKVLVRE---KRVDLIQDLPRVELQIKEAVRADHGKYIIS 11485
Query: 356 AQNSKGIVSCSGVLEV 371
A+NS G S ++ V
Sbjct: 11486 AKNSSGHAQGSAIVNV 11501
Score = 35.4 bits (80), Expect = 0.54
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1457 EGKQETLAKPRKAKDLLKAPQVIRKI--RVEQFPDASGSLKLWCQFFNILSDSVLTWAKD 1514
+G+ + +P +AKD+L+AP++ + R A +++ F +V TW KD
Sbjct: 20753 QGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV-TWRKD 20811
Query: 1515 QRPVGEVGRSA--GDEGPAALAIVQASPVDCGVYRCTIHNEHG 1555
++ +G R + + + L I Q + D G Y TI N G
Sbjct: 20812 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVG 20854
Score = 34.7 bits (78), Expect = 0.92
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
+P + S SV D++ ++G P+P +TW KD L + + +T +
Sbjct: 16732 EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ---TTRINVTDSLDLT 16788
Query: 338 TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
TL + ++D Y + N G + S +E+ T+
Sbjct: 16789 TLSIKETHKDDGGQYGITVANVVGQKTAS--IEIVTL 16823
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 271 AQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTEL-DRYCGLPKYE 329
+QL +P+F S E RF V G P PE W+ D ++ + Y K
Sbjct: 1403 SQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY--THKVV 1460
Query: 330 ITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLK 388
I G + +L + D+ + AQN G S S +L V + E+++ + KLK
Sbjct: 1461 IKEDGTQ-SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV-EHQVKPMFVEKLK 1517
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 3/84 (3%)
Query: 278 QPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH 337
QP + + S+ D++ V G P P ++W KD L + + +
Sbjct: 17814 QPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQ---TTRVNVEETATST 17870
Query: 338 TLQLYRCREEDAAIYQASAQNSKG 361
L + ++D Y +A NS G
Sbjct: 17871 VLHIKEGNKDDFGKYTVTATNSAG 17894
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 296 VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQAS 355
+R +VTG P P W K++ ELD+ + I + G + L + +D Y +
Sbjct: 8625 LRIPAVVTGRPVPTKVWTKEEGELDK----DRVVIDNVGTKSELIIKDALRKDHGRYVIT 8680
Query: 356 AQNSKGIVSCSGVLEV 371
A NS G + +EV
Sbjct: 8681 ATNSCGSKFAAARVEV 8696
Score = 33.9 bits (76), Expect = 1.6
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 289 SVSEDSDVRFTCIVTGYPEPEVTWYKDD--TELDRYCGLPKYEITHQGNRHTLQLYRCRE 346
+V +R V G P PEV W KD T+L R P+ +I + + L + +
Sbjct: 11715 TVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTR---SPRVKIDTRADSSKFSLTKAKR 11771
Query: 347 EDAAIYQASAQNSKG 361
D Y +A N+ G
Sbjct: 11772 SDGGKYVVTATNTAG 11786
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 284 TLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYR 343
TLK+ +V+E D FT +T V W K+ L+ KY I+ +G ++L++
Sbjct: 2666 TLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLE---SNEKYAISVKGTIYSLRIKN 2722
Query: 344 CREEDAAIY 352
C D ++Y
Sbjct: 2723 CAIVDESVY 2731
Score = 33.5 bits (75), Expect = 2.0
Identities = 19/72 (26%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + VRF I+ G P P W D +E+ Y + L + C D
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD---EHYTVETDNFSSVLTIKNCLRRDT 11081
Query: 350 AIYQASAQNSKG 361
YQ + N+ G
Sbjct: 11082 GEYQITVSNAAG 11093
Score = 33.5 bits (75), Expect = 2.0
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1511 WAKDQRPVGEVGRS--AGDEGPAALAIVQASPVDCGVYRCTIHNEHGSAST 1559
W KD + + + G+ + D+G L I + D G+Y CT+ N GS S+
Sbjct: 26388 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26438
Score = 33.1 bits (74), Expect = 2.7
Identities = 33/146 (22%), Positives = 58/146 (39%), Gaps = 19/146 (13%)
Query: 252 SSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDV-RFTCIVTGYPEPEV 310
+++ +S PS ST I+ E + + + + V + +V + + G P P +
Sbjct: 19267 AADSVSEPSE--STGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVI 19324
Query: 311 TWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG----IVSC- 365
+W KD E++ + EI N L + C D Y + +N G V+C
Sbjct: 19325 SWAKDGIEIEERA---RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19381
Query: 366 --------SGVLEVGTMTEYKIHQRW 383
+G LE+ +T K W
Sbjct: 19382 VLDKPGPPAGPLEINGLTAEKCSLSW 19407
Score = 32.7 bits (73), Expect = 3.5
Identities = 29/98 (29%), Positives = 35/98 (35%), Gaps = 7/98 (7%)
Query: 275 EETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD---RYCGLPKYEIT 331
E P F T + + E V F C V G P+P V W K L RY K
Sbjct: 1032 EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRY----KVSYN 1087
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
Q L + +DA Y +N G S S L
Sbjct: 1088 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 3.5
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 274 TEETQPLFETT--LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEIT 331
T+E +F L +V + + VTG PEP++TW K D L + + I
Sbjct: 7187 TQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQD---KRITIE 7243
Query: 332 HQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
+ + T+ + + D Y A N G + V+EV +
Sbjct: 7244 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCG--RATAVVEVNVL 7284
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 292 EDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAI 351
E+S+ R + G P P V+W K + D + + TL +Y C++ DA
Sbjct: 13499 ENSNFRLKIPIKGKPAPSVSWKKGE---DPLATDTRVSVESSAVNTTLIVYDCQKSDAGK 13555
Query: 352 YQASAQNSKG 361
Y + +N G
Sbjct: 13556 YTITLKNVAG 13565
Score = 32.7 bits (73), Expect = 3.5
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1489 DASGSLKLWCQFFNILSDSVLTWAKDQRPV--GEVGRSAGDEGPAALAIVQASPVDCGVY 1546
+ G +K C+ N + +TW R + E ++G A L + + +D G Y
Sbjct: 25083 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25142
Query: 1547 RCTIHNEHGSAST 1559
RC + N++G S+
Sbjct: 25143 RCKVVNDYGEDSS 25155
Score = 32.3 bits (72), Expect = 4.5
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 304 GYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIV 363
G P PE+TW +++ E K +I N L + C DA Y +NS G
Sbjct: 17553 GRPTPEITWSREEGEF-----TDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 17607
Query: 364 SCSGVLEV 371
S ++V
Sbjct: 17608 SAFVTVKV 17615
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/83 (25%), Positives = 31/83 (37%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F+ + +V D++ G P P VTW+KD+ L + + N
Sbjct: 15651 PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQ---TTRVNAESTENNSL 15707
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + ED Y NS G
Sbjct: 15708 LTIKDACREDVGHYVVKLTNSAG 15730
Score = 32.0 bits (71), Expect = 5.9
Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 8/99 (8%)
Query: 276 ETQPLFETTLKSRS---VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
E +PLF+ + R V + T G P P V W K DT+L + +
Sbjct: 19684 EEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL-----RTRAYVDT 19738
Query: 333 QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
+R +L + D+ Y + QN S + V++V
Sbjct: 19739 TDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 19777
Score = 31.6 bits (70), Expect = 7.7
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 5/82 (6%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V + +R G P P W K D+ L + +I + TL + C DA
Sbjct: 21872 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL-----RADIHTTDSFSTLTVENCNRNDA 21926
Query: 350 AIYQASAQNSKGIVSCSGVLEV 371
Y + +N+ G S + ++V
Sbjct: 21927 GKYTLTVENNSGSKSITFTVKV 21948
>gi|153792294 myopalladin [Homo sapiens]
Length = 1320
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/93 (36%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L+SR V E + V+ CIV G P P+V WY + EL+ P I GN H+
Sbjct: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIHIVQAGNLHS 325
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L + EED Y A N G S S + +
Sbjct: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
Score = 54.7 bits (130), Expect = 9e-07
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 1/96 (1%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P+F+ LK V+E S V FTC + G P P+V W+KD ++ + K G +
Sbjct: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT-CS 1003
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTM 374
L + +D Y A N +G +SCSG L V ++
Sbjct: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
Score = 47.0 bits (110), Expect = 2e-04
Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 261 SGRSTFCSIIAQLTEETQ--PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTE 318
+G+++F ++ + +E + P+ L++ V E VR C V G P P W KD+
Sbjct: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNET 1211
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYR-CREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEY 377
+ C + + + L + ++ DA Y SA+N GIVSC+ L++ +
Sbjct: 1212 IP--CTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHH 1269
Query: 378 KI 379
+I
Sbjct: 1270 QI 1271
Score = 44.7 bits (104), Expect = 9e-04
Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH- 337
P+F L++ S SE V F C V G P P+V WY++ T ++ P + I + R
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIE---DSPDFRILQKKPRSM 491
Query: 338 -------TLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
TL + ED+ + +A N G VS L V
Sbjct: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
Score = 32.0 bits (71), Expect = 5.9
Identities = 46/192 (23%), Positives = 73/192 (38%), Gaps = 22/192 (11%)
Query: 1393 VSPRGPRKSL-VPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDT 1451
+S R R S+ +P T E + ++A E +A E A GD P L
Sbjct: 202 LSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYY 261
Query: 1452 EVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTW 1511
E E L +P P+ +K+R + P+ + ++L C I V +
Sbjct: 262 E--------EPLGQP---------PRFTQKLRSREVPEGT-RVQLDCIVVGIPPPQVRWY 303
Query: 1512 AKDQRPVGEVGRSAGDEGPA-ALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSG 1570
+ + G +L I +A D G Y C N +G+ ST + E +S
Sbjct: 304 CEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
Query: 1571 FISREEGEVGEE 1582
S EG+ +E
Sbjct: 364 --SDSEGDPNKE 373
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 58.9 bits (141), Expect = 5e-08
Identities = 157/776 (20%), Positives = 240/776 (30%), Gaps = 110/776 (14%)
Query: 400 QSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQ----EG 455
Q K++K P ++ ++ R ++ P P P + G L
Sbjct: 48 QCKKYDKCCPDYESFCAEVKDNKKNRTKK-----KPTPKPPVVDEAGSGLDNGDFKVTTP 102
Query: 456 ETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEESG 515
+T T QH+ + + + + P N + + LT + +E+
Sbjct: 103 DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLT-------------VNKETT 149
Query: 516 AKKKKKDEESKQ-GLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRG 574
+ K+ +KQ E +A+ +S E P S P + +T +G
Sbjct: 150 VETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT--PKAETTTKG 207
Query: 575 RAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEE 634
A P + ++PAS TP K P P + + K+ T++ +E
Sbjct: 208 PALTTPKEPTPTTPKEPAST--TP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 261
Query: 635 GPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEA 694
T + +PK AP + PT P PT P K+ AP PK A
Sbjct: 262 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP---KKPAPTTPKEPA 318
Query: 695 ---------TTDSKPISSLSQ-APECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQG 744
TT +P + + AP + AP + + P PA T
Sbjct: 319 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378
Query: 745 QAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQ 804
+ TP E T +APT + + +T EP T+E T+ +
Sbjct: 379 EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK-----EPSPTTTKEPAPTTPKE 433
Query: 805 RTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMM 864
+ A T + T + A T+ A T K P +
Sbjct: 434 PAPTTPKKPAP-------TTPKEPAPTTPKEPAPTTTKKPAPT-TPKEPAPTTPKETAPT 485
Query: 865 TQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAME- 923
T + T EK+ T E APT E
Sbjct: 486 TPKKL-----TPTTPEKLAP---------------------------TTPEKPAPTTPEE 513
Query: 924 -GQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVV 982
+ E T P P P A P P PK+P E A
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTP--------KEPAPTTPKEPAPTTPKEPAPT 565
Query: 983 TASRNHEQTVLGPLSGNLMLPA-QPPHEGSVEQVGGERCRGPQSS---GPVEAKQEDSPF 1038
T T G L PA P + + +++ + P S+ P + +
Sbjct: 566 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 625
Query: 1039 QCPKEERP----GGVPCMDQGGCPLAGLSQEVPTMPSLPG-TGLTASPKAGPCSTPTSQH 1093
PKE P P +G P L + PT P P L + GP ST TS
Sbjct: 626 TTPKEPAPTTPKEPAPTTPKGTAPTT-LKEPAPTTPKKPAPKELAPTTTKGPTST-TSDK 683
Query: 1094 GSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTP 1149
+ T + APT T PP T + S + P ++P
Sbjct: 684 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP 739
Score = 56.2 bits (134), Expect = 3e-07
Identities = 112/480 (23%), Positives = 166/480 (34%), Gaps = 86/480 (17%)
Query: 511 KEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQT 570
KE + KK + + L EK A + + E P++ E + T E T
Sbjct: 480 KETAPTTPKKLTPTTPEKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPE----EPAPT 533
Query: 571 QPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRP 630
P+ A P + ++PA TP K P P +E + T
Sbjct: 534 TPKAAAPNTPKEPAPTTPKEPAPT--TP----KEPAPTTPKETAPTTPKGTAPTT----- 582
Query: 631 LGEEGPQTLSVRAPGE--------------------SPKGKAPLRARSEGVPGAPGQPTH 670
L E P T AP E +PKG AP + E P P +P
Sbjct: 583 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAP 641
Query: 671 SLTPQPTRPFNRKRFAPPKPKGEA------TTDSKPISSLSQ-------------APECG 711
+ TP+ T P K AP PK A TT P S+ S P+
Sbjct: 642 T-TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 700
Query: 712 AQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSS 771
A + K P + + P PP T +T + H++P E + + PT A +S
Sbjct: 701 APTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDESTP-ELSAEPTPKALENS 758
Query: 772 DVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQT 831
GV T+ + +P T +D T + RT + + A K+ + T + T
Sbjct: 759 P-KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPETTTAAPKMTKETATTTEKTTE 816
Query: 832 AQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQAD 891
++ T TQV + T + P T L+TT K+ +K
Sbjct: 817 SKITAT--TTQVTSTTTQDTTPFK--------------ITTLKTTTLAPKVTTTKKTIT- 859
Query: 892 KGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPS-----RTPKLPPT 946
T E E ++ T S+ + P + + TS P R PK PT
Sbjct: 860 --TTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 917
Score = 35.0 bits (79), Expect = 0.70
Identities = 74/351 (21%), Positives = 104/351 (29%), Gaps = 46/351 (13%)
Query: 829 TQTAQRTRADRKTQVDAGTQESKRPQ----SDRSAQKGMMTQGRAETQLETTQAGEKIQE 884
T T Q + ++ + RP SD S + + ET +ET +E
Sbjct: 104 TSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVN--KETTVET-------KE 154
Query: 885 DRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTA--MEGQSEQEVATSLGPPSRTPK 942
T + K Q + T ++ APT+ + + + T+ GP TPK
Sbjct: 155 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 214
Query: 943 LPPTAGPRAPLNIECFVQTP-------------------EGSCFPKKPGCLPRSEEAVVT 983
P P+ P + TP PK+P E A T
Sbjct: 215 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 274
Query: 984 ASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKE 1043
T P P E + P+ P K E +P PKE
Sbjct: 275 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-EPTP-TTPKE 332
Query: 1044 ERP---GGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFL 1100
P P + P A + PT P P +PK P T T + T
Sbjct: 333 PAPTTKEPAPTTPKEPAPTAP-KKPAPTTPKEPA---PTTPKE-PAPTTTKEPSPTTPKE 387
Query: 1101 PSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGP 1151
P+ SAPT T P T S + + P P
Sbjct: 388 PA--PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 58.9 bits (141), Expect = 5e-08
Identities = 157/776 (20%), Positives = 240/776 (30%), Gaps = 110/776 (14%)
Query: 400 QSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQ----EG 455
Q K++K P ++ ++ R ++ P P P + G L
Sbjct: 89 QCKKYDKCCPDYESFCAEVKDNKKNRTKK-----KPTPKPPVVDEAGSGLDNGDFKVTTP 143
Query: 456 ETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEESG 515
+T T QH+ + + + + P N + + LT + +E+
Sbjct: 144 DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLT-------------VNKETT 190
Query: 516 AKKKKKDEESKQ-GLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRG 574
+ K+ +KQ E +A+ +S E P S P + +T +G
Sbjct: 191 VETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT--PKAETTTKG 248
Query: 575 RAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEE 634
A P + ++PAS TP K P P + + K+ T++ +E
Sbjct: 249 PALTTPKEPTPTTPKEPAST--TP----KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 302
Query: 635 GPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEA 694
T + +PK AP + PT P PT P K+ AP PK A
Sbjct: 303 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP---KKPAPTTPKEPA 359
Query: 695 ---------TTDSKPISSLSQ-APECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQG 744
TT +P + + AP + AP + + P PA T
Sbjct: 360 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419
Query: 745 QAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQ 804
+ TP E T +APT + + +T EP T+E T+ +
Sbjct: 420 EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPK-----EPSPTTTKEPAPTTPKE 474
Query: 805 RTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMM 864
+ A T + T + A T+ A T K P +
Sbjct: 475 PAPTTPKKPAP-------TTPKEPAPTTPKEPAPTTTKKPAPT-TPKEPAPTTPKETAPT 526
Query: 865 TQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAME- 923
T + T EK+ T E APT E
Sbjct: 527 TPKKL-----TPTTPEKLAP---------------------------TTPEKPAPTTPEE 554
Query: 924 -GQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVV 982
+ E T P P P A P P PK+P E A
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTP--------KEPAPTTPKEPAPTTPKEPAPT 606
Query: 983 TASRNHEQTVLGPLSGNLMLPA-QPPHEGSVEQVGGERCRGPQSS---GPVEAKQEDSPF 1038
T T G L PA P + + +++ + P S+ P + +
Sbjct: 607 TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 666
Query: 1039 QCPKEERP----GGVPCMDQGGCPLAGLSQEVPTMPSLPG-TGLTASPKAGPCSTPTSQH 1093
PKE P P +G P L + PT P P L + GP ST TS
Sbjct: 667 TTPKEPAPTTPKEPAPTTPKGTAPTT-LKEPAPTTPKKPAPKELAPTTTKGPTST-TSDK 724
Query: 1094 GSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTP 1149
+ T + APT T PP T + S + P ++P
Sbjct: 725 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP 780
Score = 56.2 bits (134), Expect = 3e-07
Identities = 112/480 (23%), Positives = 166/480 (34%), Gaps = 86/480 (17%)
Query: 511 KEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQT 570
KE + KK + + L EK A + + E P++ E + T E T
Sbjct: 521 KETAPTTPKKLTPTTPEKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPE----EPAPT 574
Query: 571 QPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRP 630
P+ A P + ++PA TP K P P +E + T
Sbjct: 575 TPKAAAPNTPKEPAPTTPKEPAPT--TP----KEPAPTTPKETAPTTPKGTAPTT----- 623
Query: 631 LGEEGPQTLSVRAPGE--------------------SPKGKAPLRARSEGVPGAPGQPTH 670
L E P T AP E +PKG AP + E P P +P
Sbjct: 624 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAP 682
Query: 671 SLTPQPTRPFNRKRFAPPKPKGEA------TTDSKPISSLSQ-------------APECG 711
+ TP+ T P K AP PK A TT P S+ S P+
Sbjct: 683 T-TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 741
Query: 712 AQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSS 771
A + K P + + P PP T +T + H++P E + + PT A +S
Sbjct: 742 APTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDESTP-ELSAEPTPKALENS 799
Query: 772 DVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQT 831
GV T+ + +P T +D T + RT + + A K+ + T + T
Sbjct: 800 P-KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT-TPETTTAAPKMTKETATTTEKTTE 857
Query: 832 AQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQAD 891
++ T TQV + T + P T L+TT K+ +K
Sbjct: 858 SKITAT--TTQVTSTTTQDTTPFK--------------ITTLKTTTLAPKVTTTKKTIT- 900
Query: 892 KGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPS-----RTPKLPPT 946
T E E ++ T S+ + P + + TS P R PK PT
Sbjct: 901 --TTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPT 958
Score = 35.0 bits (79), Expect = 0.70
Identities = 74/351 (21%), Positives = 104/351 (29%), Gaps = 46/351 (13%)
Query: 829 TQTAQRTRADRKTQVDAGTQESKRPQ----SDRSAQKGMMTQGRAETQLETTQAGEKIQE 884
T T Q + ++ + RP SD S + + ET +ET +E
Sbjct: 145 TSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVN--KETTVET-------KE 195
Query: 885 DRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTA--MEGQSEQEVATSLGPPSRTPK 942
T + K Q + T ++ APT+ + + + T+ GP TPK
Sbjct: 196 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 255
Query: 943 LPPTAGPRAPLNIECFVQTP-------------------EGSCFPKKPGCLPRSEEAVVT 983
P P+ P + TP PK+P E A T
Sbjct: 256 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 315
Query: 984 ASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKE 1043
T P P E + P+ P K E +P PKE
Sbjct: 316 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPK-EPTP-TTPKE 373
Query: 1044 ERP---GGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFL 1100
P P + P A + PT P P +PK P T T + T
Sbjct: 374 PAPTTKEPAPTTPKEPAPTAP-KKPAPTTPKEPA---PTTPKE-PAPTTTKEPSPTTPKE 428
Query: 1101 PSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGP 1151
P+ SAPT T P T S + + P P
Sbjct: 429 PA--PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/153 (29%), Positives = 69/153 (45%), Gaps = 10/153 (6%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
LT + P+F T L+++ V + V F C+VTG P P V W+KD L+ Y I
Sbjct: 5120 LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEED---DHYMINE 5176
Query: 333 -QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVG-TMTEY-----KIHQRWFA 385
Q H L + D +Y+ A+NS G+ S L V T T+Y +
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 386 KLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKL 418
+ +++ +E +S E +P V+ LR L
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDL 5269
Score = 50.1 bits (118), Expect = 2e-05
Identities = 31/96 (32%), Positives = 40/96 (41%), Gaps = 1/96 (1%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F S V E S+ F C V G P P V+W KD L G P+ + G
Sbjct: 107 EQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDG-PRVRVEELGE 165
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L++ R D Y+ A+N G S + L V
Sbjct: 166 ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 47.0 bits (110), Expect = 2e-04
Identities = 42/179 (23%), Positives = 71/179 (39%), Gaps = 14/179 (7%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CS + ++ + P F +++ E D +FTC + G P P++ WYKD L
Sbjct: 6096 CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQ 6155
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGT---MTEYKIHQRW 383
G L + +ED +Y+ N G S L + + + + H+
Sbjct: 6156 TLSEPRSG-LLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQ 6214
Query: 384 FAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTR 442
AA ++ E E + + E T SP R +R S +++P S P+R
Sbjct: 6215 LV-----AAVEVTEQETKVPKKTVIIEETITTVVKSP----RGQRRSPSKSPSRS-PSR 6263
Score = 42.4 bits (98), Expect = 0.004
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 22/89 (24%)
Query: 283 TTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH----- 337
T ++ +V+E R +C VTG P+PE W KD ++ +G RH
Sbjct: 242 TGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDG------------QLVTEGRRHVVYED 289
Query: 338 -----TLQLYRCREEDAAIYQASAQNSKG 361
L++ C++ D +Y +A N G
Sbjct: 290 AQENFVLKILFCKQSDRGLYTCTASNLVG 318
Score = 40.0 bits (92), Expect = 0.022
Identities = 82/357 (22%), Positives = 131/357 (36%), Gaps = 68/357 (19%)
Query: 1253 GRQALAAARGSWGPGPSSLTV---PAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQ 1309
G A+GS P ++ V PA V + P L E A EG+ + E L +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEA---LARKR 4747
Query: 1310 ESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQE---EKFPGEALTGLPA-----ATPEEL 1361
S + P+ +SI++ P ++ ++ P EA P +T +EL
Sbjct: 4748 RMS---------------REPTLDSISELPEEDGRSQRLPQEAEEVAPDLSEGYSTADEL 4792
Query: 1362 ALGARRKRFLPKVRAAGDGEAT-TPEERESPTVSPRGPRKSLVP--GSPGTPGRERRSPT 1418
A GD + + T + ES +P SLV G PG +
Sbjct: 4793 A-------------RTGDADLSHTSSDDESRAGTP-----SLVTYLKKAGRPGTSPLASK 4834
Query: 1419 QGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQV 1478
G A+ P+ ++E A P G L T+ D + K + A K +
Sbjct: 4835 VGAPAAPSVKPQQQQEPLAA---VRPPLGDLSTKDLGDPSMDKAAVKIQAAFKGYKVRKE 4891
Query: 1479 IRKIRVEQFPDASG--------SLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDE-- 1528
+++ F G +L+L C + +D W KD + + D+
Sbjct: 4892 MKQQEGPMFSHTFGDTEAQVGDALRLECVVAS-KADVRARWLKDGVELTDGRHHHIDQLG 4950
Query: 1529 -GPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIE 1584
G +L I D G Y C + N+ G + C+ V+SG S E G E++
Sbjct: 4951 DGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACV---VVSGSESEAESSSGGELD 5004
Score = 38.9 bits (89), Expect = 0.049
Identities = 24/98 (24%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 288 RSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD-RYCG--LPKYEITHQGNRHTLQLYRC 344
+ V + S + F+ V G P P V W +++ E + G P Y + +H+L L
Sbjct: 5380 KKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDV 5439
Query: 345 REEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQR 382
+ Y A N+ G CS L V + + + ++
Sbjct: 5440 GRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEEQEK 5477
Score = 38.5 bits (88), Expect = 0.063
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 29/159 (18%)
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASA 356
+F V GYP P + W+KD L + +T + HTL++ ED+ Y A
Sbjct: 5279 KFQLKVKGYPAPRLYWFKDGQPLTASAHI---RMTDKKILHTLEIISVTREDSGQYAAYI 5335
Query: 357 QNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLR 416
N+ G S A+L + + E S HE+ VP + L
Sbjct: 5336 SNAMGAAYSS------------------ARLLVRGPDEPEEKPASDVHEQLVPPRM--LE 5375
Query: 417 KLSPDRFQRKRRLS-GAQAPGPSVPT-----REPEGGTL 449
+ +P + ++ ++ + G VPT E E G L
Sbjct: 5376 RFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVL 5414
Score = 37.7 bits (86), Expect = 0.11
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 22/107 (20%)
Query: 274 TEETQPLFETT----LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKY- 328
TE T E T L+ +E+ F+C ++ + + EV W + G+P Y
Sbjct: 2549 TEVTVEAREVTVTGPLQDAEATEEGWASFSCELS-HEDEEVEWSLN--------GMPLYN 2599
Query: 329 ----EITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
EI+H+G RHTL L + DA I +AS+ VS S LEV
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVRASSLK----VSTSARLEV 2642
Score = 37.4 bits (85), Expect = 0.14
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F T K+ VS D +C + G P P+V+W KD + ++ + G+ +
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV---AAGARFRLAQDGDLYR 66
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + D+ Y A+N+ G
Sbjct: 67 LTILDLALGDSGQYVCRARNAIG 89
Score = 37.4 bits (85), Expect = 0.14
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E D+ T + VTW KD E+ R ++E QG+ HTL ++ + D+
Sbjct: 1730 VKEHEDIILTATLATPSAATVTWLKDGVEIRRS---KRHETASQGDTHTLTVHGAQVLDS 1786
Query: 350 AIY 352
AIY
Sbjct: 1787 AIY 1789
Score = 36.2 bits (82), Expect = 0.31
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 18/147 (12%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPE-VTWYKDDTE 318
SS R I LT +P +T + +SV D R P P+ V WYKDDT
Sbjct: 2458 SSARLVVSDIPVVLTRPLEP--KTGRELQSVVLSCDFR--------PAPKAVQWYKDDTP 2507
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASA----QNSKGIVSCSGVLEVGTM 374
L K++++ +G L++ R DA +Y+ A +++ V V G +
Sbjct: 2508 LS---PSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPL 2564
Query: 375 TEYKIHQRWFAKLKRKAAAKLREIEQS 401
+ + + +A + + + E+E S
Sbjct: 2565 QDAEATEEGWASFSCELSHEDEEVEWS 2591
Score = 35.0 bits (79), Expect = 0.70
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKD 315
P FE L + V+ C VTG P+P ++WYKD
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKD 6050
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 1493 SLKLWCQFFNILSDSVLTWAKDQRPVG--EVGRSAGDEGPAALAIVQASPVDCGVYRCTI 1550
S+ L C F + + W KD P+ E + + + A L I++ P D GVYRC
Sbjct: 2485 SVVLSCDFRP--APKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1551 HNEHGS 1556
+ H S
Sbjct: 2543 GSAHSS 2548
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 58.5 bits (140), Expect = 6e-08
Identities = 45/153 (29%), Positives = 69/153 (45%), Gaps = 10/153 (6%)
Query: 273 LTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITH 332
LT + P+F T L+++ V + V F C+VTG P P V W+KD L+ Y I
Sbjct: 5120 LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEED---DHYMINE 5176
Query: 333 -QGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVG-TMTEY-----KIHQRWFA 385
Q H L + D +Y+ A+NS G+ S L V T T+Y +
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 386 KLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKL 418
+ +++ +E +S E +P V+ LR L
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDL 5269
Score = 54.3 bits (129), Expect = 1e-06
Identities = 43/172 (25%), Positives = 74/172 (43%), Gaps = 20/172 (11%)
Query: 267 CSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP 326
CS + ++ + P F +++ E D +FTC + G P P++ WYKD L
Sbjct: 6096 CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTG---N 6152
Query: 327 KYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAK 386
K++ + L L + +A+++ G+ C V +G+ R A+
Sbjct: 6153 KFQTLSEPRSGLLVL---------VIRAASKEDLGLYECELVNRLGS-------ARASAE 6196
Query: 387 LKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPS 438
L R + L+ EQ + + E TL + + +RL G +APGPS
Sbjct: 6197 L-RIQSPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPS 6247
Score = 53.1 bits (126), Expect = 2e-06
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P + T++ +F I+ G P+P VTWYKD +L L + + +G ++
Sbjct: 6357 PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQ---EGTTYS 6413
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L L +DA +Y AQN+ G V C L V
Sbjct: 6414 LVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 6446
Score = 50.1 bits (118), Expect = 2e-05
Identities = 31/96 (32%), Positives = 40/96 (41%), Gaps = 1/96 (1%)
Query: 276 ETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGN 335
E P F S V E S+ F C V G P P V+W KD L G P+ + G
Sbjct: 107 EQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDG-PRVRVEELGE 165
Query: 336 RHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
L++ R D Y+ A+N G S + L V
Sbjct: 166 ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 44.7 bits (104), Expect = 9e-04
Identities = 72/296 (24%), Positives = 103/296 (34%), Gaps = 43/296 (14%)
Query: 647 SPKGKAPLR--ARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSL 704
+P G AP+R +G P H T QP RP + P P S P
Sbjct: 6988 APSGGAPIRDMGHPQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGC 7047
Query: 705 SQAPECGAQSLGKAPPQASVQVP------------TPPARRRHGTRDSTLQGQAGHRTPG 752
S P G PP + + P PPA + + G PG
Sbjct: 7048 SPHPAVAPCPPGSFPPGSCKEAPLVPSSPFLGQPQAPPAPAKASPPLDSKMGPGDISLPG 7107
Query: 753 EVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEP---MDME--TQEDGRTSANQRTG 807
++ + S +SSS V+S+ V + SQ EP +D E TQE S + T
Sbjct: 7108 RPKPGPCSSPGSASQASSSQVSSLRVGS--SQVGTEPGPSLDAEGWTQEAEDLSDSTPTL 7165
Query: 808 SKKNVQAD-GKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQ 866
+ QA K + GR G DAG GM+ Q
Sbjct: 7166 QRPQEQATMRKFSLGGR----GGYAGVAGYGTFAFGGDAG---------------GMLGQ 7206
Query: 867 GR--AETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPT 920
G A +Q+ E+ QE+ +A++ Q++ R + + G APT
Sbjct: 7207 GPMWARIAWAVSQSEEEEQEEARAESQSEEQQEARAESPLPQVSARPVPEVGRAPT 7262
Score = 42.4 bits (98), Expect = 0.004
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 22/89 (24%)
Query: 283 TTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRH----- 337
T ++ +V+E R +C VTG P+PE W KD ++ +G RH
Sbjct: 242 TGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDG------------QLVTEGRRHVVYED 289
Query: 338 -----TLQLYRCREEDAAIYQASAQNSKG 361
L++ C++ D +Y +A N G
Sbjct: 290 AQENFVLKILFCKQSDRGLYTCTASNLVG 318
Score = 40.0 bits (92), Expect = 0.022
Identities = 82/357 (22%), Positives = 131/357 (36%), Gaps = 68/357 (19%)
Query: 1253 GRQALAAARGSWGPGPSSLTV---PAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQ 1309
G A+GS P ++ V PA V + P L E A EG+ + E L +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEA---LARKR 4747
Query: 1310 ESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQE---EKFPGEALTGLPA-----ATPEEL 1361
S + P+ +SI++ P ++ ++ P EA P +T +EL
Sbjct: 4748 RMS---------------REPTLDSISELPEEDGRSQRLPQEAEEVAPDLSEGYSTADEL 4792
Query: 1362 ALGARRKRFLPKVRAAGDGEAT-TPEERESPTVSPRGPRKSLVP--GSPGTPGRERRSPT 1418
A GD + + T + ES +P SLV G PG +
Sbjct: 4793 A-------------RTGDADLSHTSSDDESRAGTP-----SLVTYLKKAGRPGTSPLASK 4834
Query: 1419 QGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQV 1478
G A+ P+ ++E A P G L T+ D + K + A K +
Sbjct: 4835 VGAPAAPSVKPQQQQEPLAA---VRPPLGDLSTKDLGDPSMDKAAVKIQAAFKGYKVRKE 4891
Query: 1479 IRKIRVEQFPDASG--------SLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDE-- 1528
+++ F G +L+L C + +D W KD + + D+
Sbjct: 4892 MKQQEGPMFSHTFGDTEAQVGDALRLECVVAS-KADVRARWLKDGVELTDGRHHHIDQLG 4950
Query: 1529 -GPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIE 1584
G +L I D G Y C + N+ G + C+ V+SG S E G E++
Sbjct: 4951 DGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACV---VVSGSESEAESSSGGELD 5004
Score = 38.9 bits (89), Expect = 0.049
Identities = 24/98 (24%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 288 RSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELD-RYCG--LPKYEITHQGNRHTLQLYRC 344
+ V + S + F+ V G P P V W +++ E + G P Y + +H+L L
Sbjct: 5380 KKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDV 5439
Query: 345 REEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQR 382
+ Y A N+ G CS L V + + + ++
Sbjct: 5440 GRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEEQEK 5477
Score = 38.5 bits (88), Expect = 0.063
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 29/159 (18%)
Query: 297 RFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASA 356
+F V GYP P + W+KD L + +T + HTL++ ED+ Y A
Sbjct: 5279 KFQLKVKGYPAPRLYWFKDGQPLTASAHI---RMTDKKILHTLEIISVTREDSGQYAAYI 5335
Query: 357 QNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLR 416
N+ G S A+L + + E S HE+ VP + L
Sbjct: 5336 SNAMGAAYSS------------------ARLLVRGPDEPEEKPASDVHEQLVPPRM--LE 5375
Query: 417 KLSPDRFQRKRRLS-GAQAPGPSVPT-----REPEGGTL 449
+ +P + ++ ++ + G VPT E E G L
Sbjct: 5376 RFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVL 5414
Score = 37.7 bits (86), Expect = 0.11
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 22/107 (20%)
Query: 274 TEETQPLFETT----LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKY- 328
TE T E T L+ +E+ F+C ++ + + EV W + G+P Y
Sbjct: 2549 TEVTVEAREVTVTGPLQDAEATEEGWASFSCELS-HEDEEVEWSLN--------GMPLYN 2599
Query: 329 ----EITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV 371
EI+H+G RHTL L + DA I +AS+ VS S LEV
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVRASSLK----VSTSARLEV 2642
Score = 37.4 bits (85), Expect = 0.14
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F T K+ VS D +C + G P P+V+W KD + ++ + G+ +
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV---AAGARFRLAQDGDLYR 66
Query: 339 LQLYRCREEDAAIYQASAQNSKG 361
L + D+ Y A+N+ G
Sbjct: 67 LTILDLALGDSGQYVCRARNAIG 89
Score = 37.4 bits (85), Expect = 0.14
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 290 VSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA 349
V E D+ T + VTW KD E+ R ++E QG+ HTL ++ + D+
Sbjct: 1730 VKEHEDIILTATLATPSAATVTWLKDGVEIRRS---KRHETASQGDTHTLTVHGAQVLDS 1786
Query: 350 AIY 352
AIY
Sbjct: 1787 AIY 1789
Score = 36.2 bits (82), Expect = 0.31
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 18/147 (12%)
Query: 260 SSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPE-VTWYKDDTE 318
SS R I LT +P +T + +SV D R P P+ V WYKDDT
Sbjct: 2458 SSARLVVSDIPVVLTRPLEP--KTGRELQSVVLSCDFR--------PAPKAVQWYKDDTP 2507
Query: 319 LDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASA----QNSKGIVSCSGVLEVGTM 374
L K++++ +G L++ R DA +Y+ A +++ V V G +
Sbjct: 2508 LS---PSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPL 2564
Query: 375 TEYKIHQRWFAKLKRKAAAKLREIEQS 401
+ + + +A + + + E+E S
Sbjct: 2565 QDAEATEEGWASFSCELSHEDEEVEWS 2591
Score = 35.0 bits (79), Expect = 0.70
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKD 315
P FE L + V+ C VTG P+P ++WYKD
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKD 6050
Score = 35.0 bits (79), Expect = 0.70
Identities = 25/91 (27%), Positives = 35/91 (38%), Gaps = 2/91 (2%)
Query: 279 PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHT 338
P F L +V V C V+ P + TW KD L+ + N
Sbjct: 7463 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRV--LISATLKNFQL 7520
Query: 339 LQLYRCREEDAAIYQASAQNSKGIVSCSGVL 369
L + ED +Y S N+ G V+ +GVL
Sbjct: 7521 LTILVVVAEDLGVYTCSVSNALGTVTTTGVL 7551
Score = 33.5 bits (75), Expect = 2.0
Identities = 50/204 (24%), Positives = 68/204 (33%), Gaps = 61/204 (29%)
Query: 993 LGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKE--------- 1043
+G G+ LP+ H G+ + P+ P + +PF PK+
Sbjct: 6998 MGHPQGSKQLPSTGGHPGTAQ---------PERPSPDSPWGQPAPFCHPKQGSAPQEGCS 7048
Query: 1044 ERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTG-------------------------LT 1078
P PC G P G +E P +PS P G L
Sbjct: 7049 PHPAVAPC-PPGSFP-PGSCKEAPLVPSSPFLGQPQAPPAPAKASPPLDSKMGPGDISLP 7106
Query: 1079 ASPKAGPCSTPTSQHGSTATFLPS----EDQVLMSSAPTL----------HLGLGTPTQS 1124
PK GPCS+P S ++++ + S QV P+L L TPT
Sbjct: 7107 GRPKPGPCSSPGSASQASSSQVSSLRVGSSQVGTEPGPSLDAEGWTQEAEDLSDSTPTLQ 7166
Query: 1125 HPPE--TMATSSEGACAQVPDVEG 1146
P E TM S G V G
Sbjct: 7167 RPQEQATMRKFSLGGRGGYAGVAG 7190
Score = 32.0 bits (71), Expect = 5.9
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 4/66 (6%)
Query: 1493 SLKLWCQFFNILSDSVLTWAKDQRPVG--EVGRSAGDEGPAALAIVQASPVDCGVYRCTI 1550
S+ L C F + + W KD P+ E + + + A L I++ P D GVYRC
Sbjct: 2485 SVVLSCDFRP--APKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1551 HNEHGS 1556
+ H S
Sbjct: 2543 GSAHSS 2548
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,606,574
Number of Sequences: 37866
Number of extensions: 5720381
Number of successful extensions: 41855
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 1721
Number of HSP's that attempted gapping in prelim test: 25814
Number of HSP's gapped (non-prelim): 15336
length of query: 1907
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1790
effective length of database: 13,817,196
effective search space: 24732780840
effective search space used: 24732780840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.