Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 224465231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224465231 solute carrier family 9, member 11 [Homo sapiens]
(1124 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224465231 solute carrier family 9, member 11 [Homo sapiens] 2231 0.0
gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens] 492 e-139
gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens] 56 2e-07
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 55 4e-07
gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),... 54 1e-06
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 52 3e-06
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 52 3e-06
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 52 3e-06
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 52 3e-06
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 52 3e-06
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 52 3e-06
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 52 4e-06
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 52 4e-06
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 52 4e-06
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 52 4e-06
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 52 4e-06
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 52 4e-06
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 52 4e-06
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 51 5e-06
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 51 7e-06
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 50 9e-06
gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger)... 48 6e-05
gi|221316609 sperm-associated cation channel 1 [Homo sapiens] 47 1e-04
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 47 1e-04
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 45 5e-04
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 45 5e-04
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 45 5e-04
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 44 7e-04
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 44 7e-04
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 44 7e-04
>gi|224465231 solute carrier family 9, member 11 [Homo sapiens]
Length = 1124
Score = 2231 bits (5781), Expect = 0.0
Identities = 1124/1124 (100%), Positives = 1124/1124 (100%)
Query: 1 MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTIL 60
MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTIL
Sbjct: 1 MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTIL 60
Query: 61 SLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQV 120
SLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQV
Sbjct: 61 SLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQV 120
Query: 121 LLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIY 180
LLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIY
Sbjct: 121 LLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIY 180
Query: 181 IDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDILGSIIFGYWCAKIIQ 240
IDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDILGSIIFGYWCAKIIQ
Sbjct: 181 IDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDILGSIIFGYWCAKIIQ 240
Query: 241 CILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVIT 300
CILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVIT
Sbjct: 241 CILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVIT 300
Query: 301 KFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPIL 360
KFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPIL
Sbjct: 301 KFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPIL 360
Query: 361 MHSNYEYNWRWGVVITWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGI 420
MHSNYEYNWRWGVVITWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGI
Sbjct: 361 MHSNYEYNWRWGVVITWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGI 420
Query: 421 NSYVMTQSARKLDLCVLSLPRQMILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDK 480
NSYVMTQSARKLDLCVLSLPRQMILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDK
Sbjct: 421 NSYVMTQSARKLDLCVLSLPRQMILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDK 480
Query: 481 TRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILI 540
TRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILI
Sbjct: 481 TRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILI 540
Query: 541 GAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFI 600
GAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFI
Sbjct: 541 GAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFI 600
Query: 601 FHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKII 660
FHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKII
Sbjct: 601 FHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKII 660
Query: 661 ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLF 720
ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLF
Sbjct: 661 ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLF 720
Query: 721 KIIVPILIRIADVQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETN 780
KIIVPILIRIADVQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETN
Sbjct: 721 KIIVPILIRIADVQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETN 780
Query: 781 KQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVL 840
KQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVL
Sbjct: 781 KQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVL 840
Query: 841 LKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEM 900
LKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEM
Sbjct: 841 LKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEM 900
Query: 901 PQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEY 960
PQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEY
Sbjct: 901 PQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEY 960
Query: 961 TVICETSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNC 1020
TVICETSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNC
Sbjct: 961 TVICETSLQACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNC 1020
Query: 1021 VMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTS 1080
VMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTS
Sbjct: 1021 VMFNQAYVETLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTS 1080
Query: 1081 DLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS 1124
DLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS
Sbjct: 1081 DLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS 1124
>gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]
Length = 1177
Score = 492 bits (1267), Expect = e-139
Identities = 316/1080 (29%), Positives = 570/1080 (52%), Gaps = 45/1080 (4%)
Query: 41 LGGLLKMCLKNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLI 100
+G L L++ + V IL L G +++ S +V + + S + F+P++
Sbjct: 28 IGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVV 87
Query: 101 IFMVALDVEFYTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLG 160
F A D++ Y L+K+FWQ+LL + F I++ + + N+ LLFS L
Sbjct: 88 FFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILV 147
Query: 161 IIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRG------NRIHFSIFRD 214
DP+ + +++ +G+S+ I LI GESL+ I+ I F + ++ + ++ +
Sbjct: 148 SSDPMLTAAAIRDLGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEE 207
Query: 215 LHVGIELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMS 274
+ GI SY I+ S +FG +K+IQ ++ VF + + +I L FS++Y+ FYI E +GMS
Sbjct: 208 IVGGI-CSY-IIASFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMS 265
Query: 275 GTLALAAVGLNLDSLTFKPKIE-LVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFH 333
G LA VGL L+S +FK IE ++ +F S + +++ FFG++I + EF
Sbjct: 266 GIFTLAIVGLLLNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFV 325
Query: 334 TIPFIFILFTTVNLVRLLTILLVSPILMHSNYEYNWRWGVVITWSGIKGVFN-----LLW 388
I + ++ T+ ++R LT+LL+SP+L +E++WRW ++ S +KG+ N LL
Sbjct: 326 DIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLA 385
Query: 389 APDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNA 448
D+Y ++++ + + ++ L+T+ +N +++ + L L + + +
Sbjct: 386 YSDLYFGSDKE---KSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCT 442
Query: 449 TQHIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFS------------HVSHNDM 496
QH QE+ ++ + K +K L N +W ++E +E P+ H +
Sbjct: 443 FQHFQELTKSAASALKFDKDLANADWNMIEKAITLEN-PYMLNEEETTEHQKVKCPHCNK 501
Query: 497 KTESTTDEALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSI 556
+ + + ME A + + Q++S+++Q N IL A ++L+GAA+ + +GK MS+
Sbjct: 502 EIDEIFNTEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSL 561
Query: 557 YDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFH-IVFSEEFEYTGQI 615
+ Y ++ + + +L Y K P S F I H IVF+EEFE+ G +
Sbjct: 562 DTIKNYSESQKTVTFARKLLLNWVYNTRKEKEGP--SKYFFFRICHTIVFTEEFEHVGYL 619
Query: 616 INLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLE 675
+ L+ I+P II + S L NY F+ LY+LE+ LKI +++ +F WN E
Sbjct: 620 VILMNIFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFE 679
Query: 676 FFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRF---LPLFKIIVPILIRIAD 732
I +IGI+ + + ++ + T ++ ++++++F L +FK+I P L++I D
Sbjct: 680 LAITLIGILHVILIEIDTIK----YIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIID 735
Query: 733 VQIKKRLSLMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLME 792
++ + + Y I KGY++ + D +I QI + I Q L + + N + A+KEL +E
Sbjct: 736 KRMSHQKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLE 795
Query: 793 HEGRDVVIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVLLKKLKALNNFPK 852
++ ++ + +KTK+ I ++ A + L +GII K E INK+++ K K + +
Sbjct: 796 YDHPEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQS 855
Query: 853 AIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMA 912
I P T + L++I WL+ I+F +E+AK+ FD G+ I + G+ P+GIY+IISGM
Sbjct: 856 IIRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGMV 915
Query: 913 ILHSLSPTFGIESNQRCDRGSRD---MFTEFCTTGDIIGELSCLLKREIEYTVICETSLQ 969
L P GI+ Q + +D + T++ +G+IIGE++CL ++Y+ C+T ++
Sbjct: 916 KLEKSKPGLGID--QMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVVE 973
Query: 970 ACFISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVE 1029
CFI LY+ F+ P ++ K+WLKL L+ + L ED + + + YV
Sbjct: 974 TCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNIYVV 1033
Query: 1030 TLSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLIIQ 1089
+ + I + + +VI+++G+V D + Y AP +IP TC Q+Q D +K++IIQ
Sbjct: 1034 DIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTKVVIIQ 1093
>gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]
Length = 815
Score = 56.2 bits (134), Expect = 2e-07
Identities = 72/294 (24%), Positives = 127/294 (43%), Gaps = 39/294 (13%)
Query: 83 PLLRTSSFSLY---------SYFSPLIIFMVALD-VEFYTLKKMFWQVLLTGLISFSTAS 132
P L++ F L+ YF PL F L + + + W G + ++
Sbjct: 154 PFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVC- 212
Query: 133 IIIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKTIGISKIYIDLIRGESLIIC 192
++G I ++ L LLF + +DP+ + + I I+++ L+ GESL+
Sbjct: 213 -LVGGEQI----NNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLND 267
Query: 193 SIASIFFGNFR--GNRIHFSIFRDLHVGIELSYDI--LGSIIFGYWCAKIIQCILADVFS 248
++ + + F N H I D+ +G LS+ + LG ++ G ++ ++A S
Sbjct: 268 AVTVVLYHLFEEFANYEHVGIV-DIFLGF-LSFFVVALGGVLVG-----VVYGVIAAFTS 320
Query: 249 NMLTNI-----ILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLD---SLTFKPKIELVIT 300
++I + F YM + E +SG +AL A G+ + K I
Sbjct: 321 RFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIK 380
Query: 301 KFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTIL 354
FL+++SSV E LI+ F G+ G SH+ T +LF + R+L +L
Sbjct: 381 YFLKMWSSVSETLIFIFLGVSTVAG--SHHWNWTFVISTLLFCLI--ARVLGVL 430
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 55.1 bits (131), Expect = 4e-07
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N ++ +V + F+ T I+ + + M++ ++ L V L +IN F+
Sbjct: 1335 IPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQ-LKVDILYNINMIFI 1393
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E LK++ L++ YF WN +F ++++ I+ D+ YFV P +I+
Sbjct: 1394 IIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVS--PTLFRVIR 1451
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1452 LARIGRVLRLIR 1463
Score = 34.7 bits (78), Expect = 0.52
Identities = 29/124 (23%), Positives = 55/124 (44%), Gaps = 14/124 (11%)
Query: 600 IFHIVFSEEFEYTGQIINLIY-IYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLK 658
I H++ + F G I ++ M + +PM + + L N F ++ E LK
Sbjct: 570 IIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFD-NVLTVGNLVFTGIFTAEMVLK 628
Query: 659 IIILKR-KYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFL 717
+I + +YFQQ WN + I+ + ++++ LA +Q ++ R++R
Sbjct: 629 LIAMDPYEYFQQGWNIFDSIIVTLSLVEL-----------GLANVQGLSVLRSFRLLRVF 677
Query: 718 PLFK 721
L K
Sbjct: 678 KLAK 681
Score = 33.5 bits (75), Expect = 1.2
Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++++ + FV L
Sbjct: 159 NVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMA----YLTEFVDL-- 212
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 213 GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMI 255
>gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),
member 2 [Homo sapiens]
Length = 812
Score = 53.5 bits (127), Expect = 1e-06
Identities = 69/330 (20%), Positives = 132/330 (40%), Gaps = 41/330 (12%)
Query: 50 KNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLY---------SYFSPLI 100
++C +I++ +L L G + G V + P ++T F LY YF P
Sbjct: 110 ESCLLIMVGLL-LGGIIFG--------VDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTR 160
Query: 101 IFMVALDVEF-YTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITL 159
F + F Y + W + G+ F I F L LLF +
Sbjct: 161 PFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEA------FGLSDITLLQNLLFGSLI 214
Query: 160 GIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFR-DLHVG 218
+DP+ + + I +++ L+ GESL+ ++ + + F+ +I D+ G
Sbjct: 215 SAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAG 274
Query: 219 IELSYDI-LGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTL 277
I + + +G ++ G + I + + + F Y+++ E +SG +
Sbjct: 275 IANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIM 334
Query: 278 ALAAVGLNLDSL---TFKPKIELVITKFLRIFSSVYEHLIYAFFGI-VIGCGELSHYEF- 332
A+ A + ++ K I F+++ SSV E LI+ F G+ +G ++ F
Sbjct: 335 AITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFV 394
Query: 333 -HTIPF--------IFILFTTVNLVRLLTI 353
T+ F +F+L +N R + +
Sbjct: 395 CFTLAFCLMWRALGVFVLTQVINRFRTIPL 424
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1456 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1514
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1515 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1572
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1573 LARIGRILRLIR 1584
Score = 35.0 bits (79), Expect = 0.40
Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + ++
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLG 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
NL+ ++ ++ L+ I +P K IV LI ++ADV +
Sbjct: 214 NLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMV 255
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 6/85 (7%)
Query: 644 NYYFMFLYVLESTLKIIILKRKY-FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI 702
N F ++ E T KII L Y FQQ WN + I+++ ++++ R NL+++
Sbjct: 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGL-----SRMSNLSVL 807
Query: 703 QLTVIMGYLRIIRFLPLFKIIVPIL 727
+ ++ ++ + P ++ I+
Sbjct: 808 RSFRLLRVFKLAKSWPTLNTLIKII 832
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1568
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1569 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1626
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1627 LARIGRILRLIR 1638
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 6/85 (7%)
Query: 644 NYYFMFLYVLESTLKIIILKRKY-FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI 702
N F ++ E T KII L Y FQQ WN + I+++ ++++ R NL+++
Sbjct: 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGL-----SRMSNLSVL 807
Query: 703 QLTVIMGYLRIIRFLPLFKIIVPIL 727
+ ++ ++ + P ++ I+
Sbjct: 808 RSFRLLRVFKLAKSWPTLNTLIKII 832
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + FV L
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA----YTTEFVDL--G 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I + K IV LI ++ADV +
Sbjct: 214 NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMV 255
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1509 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1567
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1568 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1625
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1626 LARIGRILRLIR 1637
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 6/85 (7%)
Query: 644 NYYFMFLYVLESTLKIIILKRKY-FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI 702
N F ++ E T KII L Y FQQ WN + I+++ ++++ R NL+++
Sbjct: 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGL-----SRMSNLSVL 807
Query: 703 QLTVIMGYLRIIRFLPLFKIIVPIL 727
+ ++ ++ + P ++ I+
Sbjct: 808 RSFRLLRVFKLAKSWPTLNTLIKII 832
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + FV L
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA----YTTEFVDL--G 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I + K IV LI ++ADV +
Sbjct: 214 NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMV 255
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1492 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1550
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1551 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1608
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1609 LARIGRILRLIR 1620
Score = 35.0 bits (79), Expect = 0.40
Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + ++
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLG 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
NL+ ++ ++ L+ I +P K IV LI ++ADV +
Sbjct: 214 NLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMV 255
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 6/85 (7%)
Query: 644 NYYFMFLYVLESTLKIIILKRKY-FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI 702
N F ++ E T KII L Y FQQ WN + I+++ ++++ R NL+++
Sbjct: 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGL-----SRMSNLSVL 807
Query: 703 QLTVIMGYLRIIRFLPLFKIIVPIL 727
+ ++ ++ + P ++ I+
Sbjct: 808 RSFRLLRVFKLAKSWPTLNTLIKII 832
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1568
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1569 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1626
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1627 LARIGRILRLIR 1638
Score = 35.0 bits (79), Expect = 0.40
Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + ++
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLG 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
NL+ ++ ++ L+ I +P K IV LI ++ADV +
Sbjct: 214 NLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMV 255
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 6/85 (7%)
Query: 644 NYYFMFLYVLESTLKIIILKRKY-FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALI 702
N F ++ E T KII L Y FQQ WN + I+++ ++++ R NL+++
Sbjct: 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGL-----SRMSNLSVL 807
Query: 703 QLTVIMGYLRIIRFLPLFKIIVPIL 727
+ ++ ++ + P ++ I+
Sbjct: 808 RSFRLLRVFKLAKSWPTLNTLIKII 832
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/132 (27%), Positives = 62/132 (46%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N + FIF IV + F+ T + + + M++ + ++ L IN F+
Sbjct: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE-KINILAKINLLFV 1177
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGII-----DIFCVYFVKLRPDNLALIQ 703
++ E +K+ L+ YF WN +F ++++ I+ DI YF P +I+
Sbjct: 1178 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIR 1235
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1236 LARIGRILRLIR 1247
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
+ Y F +Y ES +KI+ + + + WN L+F ++++ + FV L
Sbjct: 160 VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMA----YTTEFVDL--G 213
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I + K IV LI ++ADV +
Sbjct: 214 NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMV 255
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 6/132 (4%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N F F+F IV + F+ T ++ + + M++ + L IN +F+
Sbjct: 1458 IPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEE-KTKILGKINQFFV 1516
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK-----LRPDNLALIQ 703
++ E +K+ L++ YF WN +F ++V+ I + +K P +I+
Sbjct: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
Query: 704 LTVIMGYLRIIR 715
L I LR+IR
Sbjct: 1577 LARIGRILRLIR 1588
Score = 33.1 bits (74), Expect = 1.5
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 15/102 (14%)
Query: 643 INYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPD 697
I Y F +Y E+ +KI+ + + Y + WN L+F ++ + + + LR
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGT----AIDLR-- 209
Query: 698 NLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
++ ++ ++ L+ + +P K+IV LI ++ADV I
Sbjct: 210 GISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTI 251
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 7/86 (8%)
Query: 647 FMFLYVLESTLKIIILK-RKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLT 705
F F++V E LK + +KYF W L+F I+ I +I + L +A I+
Sbjct: 1193 FTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKI---LEYSEVAPIKAL 1249
Query: 706 VIMGYLRIIRFLPLF---KIIVPILI 728
+ LR +R L F +++V L+
Sbjct: 1250 RTLRALRPLRALSRFEGMRVVVDALV 1275
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ ++ + + L IN F+
Sbjct: 1513 IPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT-NILYWINLVFI 1571
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK+I L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLA 1631
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1632 RIGRILRLIK 1641
Score = 32.7 bits (73), Expect = 2.0
Identities = 26/103 (25%), Positives = 49/103 (47%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++ + FV L
Sbjct: 157 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA----YVTEFVNL-- 210
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 253
Score = 31.6 bits (70), Expect = 4.4
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 18/109 (16%)
Query: 615 IINLIYIYPMIIHLWPMARGLNVSALISI-NYYFMFLYVLESTLKIIILKRKY-FQQCWN 672
++N ++ M + +PM S+++S+ N F ++ E LKII + Y FQ+ WN
Sbjct: 770 VLNTLF---MAMEHYPMTE--QFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 673 TLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFK 721
+ FI+ + ++++ LA ++ ++ R++R L K
Sbjct: 825 IFDGFIVSLSLMEL-----------GLANVEGLSVLRSFRLLRVFKLAK 862
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ ++ + + L IN F+
Sbjct: 1513 IPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT-NILYWINLVFI 1571
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK+I L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLA 1631
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1632 RIGRILRLIK 1641
Score = 32.3 bits (72), Expect = 2.6
Identities = 26/103 (25%), Positives = 49/103 (47%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++ + FV L
Sbjct: 157 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA----YVTEFVDL-- 210
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 253
Score = 31.6 bits (70), Expect = 4.4
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 18/109 (16%)
Query: 615 IINLIYIYPMIIHLWPMARGLNVSALISI-NYYFMFLYVLESTLKIIILKRKY-FQQCWN 672
++N ++ M + +PM S+++S+ N F ++ E LKII + Y FQ+ WN
Sbjct: 770 VLNTLF---MAMEHYPMTE--QFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 673 TLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFK 721
+ FI+ + ++++ LA ++ ++ R++R L K
Sbjct: 825 IFDGFIVSLSLMEL-----------GLANVEGLSVLRSFRLLRVFKLAK 862
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ ++ + + L IN F+
Sbjct: 1513 IPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT-NILYWINLVFI 1571
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK+I L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLA 1631
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1632 RIGRILRLIK 1641
Score = 32.3 bits (72), Expect = 2.6
Identities = 26/103 (25%), Positives = 49/103 (47%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++ + FV L
Sbjct: 157 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFA----YVTEFVDL-- 210
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 253
Score = 31.6 bits (70), Expect = 4.4
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 18/109 (16%)
Query: 615 IINLIYIYPMIIHLWPMARGLNVSALISI-NYYFMFLYVLESTLKIIILKRKY-FQQCWN 672
++N ++ M + +PM S+++S+ N F ++ E LKII + Y FQ+ WN
Sbjct: 770 VLNTLF---MAMEHYPMTE--QFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
Query: 673 TLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFK 721
+ FI+ + ++++ LA ++ ++ R++R L K
Sbjct: 825 IFDGFIVSLSLMEL-----------GLANVEGLSVLRSFRLLRVFKLAK 862
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ + + + L IN F+
Sbjct: 1459 IPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTL-VLSRINLVFI 1517
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK++ L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1518 VLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1577
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1578 RIGRILRLIK 1587
Score = 34.7 bits (78), Expect = 0.52
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++V+ + FV L
Sbjct: 156 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA----YVTEFVSL-- 209
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 252
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ + + + L IN F+
Sbjct: 1459 IPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTL-VLSRINLVFI 1517
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK++ L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1518 VLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1577
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1578 RIGRILRLIK 1587
Score = 34.3 bits (77), Expect = 0.68
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++V+ + FV L
Sbjct: 156 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA----YVTEFVDL-- 209
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 252
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP +N F +F V + F+ + I+ + + M++ + + + L IN F+
Sbjct: 1508 IPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTL-VLSRINLVFI 1566
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK++ L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1567 VLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1626
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1627 RIGRILRLIK 1636
Score = 34.3 bits (77), Expect = 0.68
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + WN L+F ++V+ + FV L
Sbjct: 156 NVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMA----YVTEFVDL-- 209
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 252
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 51.2 bits (121), Expect = 5e-06
Identities = 35/132 (26%), Positives = 64/132 (48%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N IF +V ++ F+ + ++ + + M++ ++ + L IN F+
Sbjct: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT-EVLYWINVVFI 1544
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFC-----VYFVKLRPDNLALIQ 703
L+ E LK+I L+ YF WN +F +++I I+ +F YFV P +I+
Sbjct: 1545 ILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVS--PTLFRVIR 1602
Query: 704 LTVIMGYLRIIR 715
L I LR+++
Sbjct: 1603 LARIGRILRLVK 1614
Score = 35.0 bits (79), Expect = 0.40
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KI+ + + + + WN L+F ++V + FV L
Sbjct: 154 NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFA----YLTEFVNL-- 207
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 208 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 250
Score = 32.7 bits (73), Expect = 2.0
Identities = 47/230 (20%), Positives = 94/230 (40%), Gaps = 53/230 (23%)
Query: 504 EALMEEARLHVAAIQMSSFEKQRNNGILEIEAARILIGAAKC---YYSIQGKFMSIYDVS 560
E ++ + L A+ +S N + E+E +R KC +Y KF+ I++ S
Sbjct: 666 EDMLNDPNLRQRAMSRASI---LTNTVEELEESR-----QKCPPWWYRFAHKFL-IWNCS 716
Query: 561 TYMRTRSWLIKFKNVLTFL--EYCIEKIHFIPPESNTFLTFIFHIVFSEEFEYTGQIINL 618
Y W IKFK + F+ + ++ I NT + H +EEF+ I NL
Sbjct: 717 PY-----W-IKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNL 770
Query: 619 IYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKR-KYFQQCWNTLEFF 677
+ F ++ E LK+I + +YFQ WN +
Sbjct: 771 V---------------------------FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSL 803
Query: 678 ILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIVPIL 727
I+ + ++++F + L++++ ++ ++ + P +++ I+
Sbjct: 804 IVTLSLVELFLA-----DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKII 848
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 50.8 bits (120), Expect = 7e-06
Identities = 33/130 (25%), Positives = 63/130 (48%), Gaps = 4/130 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N F +F V + F+ + I+ + + M++ + + + L IN F+
Sbjct: 1512 IPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVT-TILSRINLVFI 1570
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK---LRPDNLALIQLT 705
L+ E LK+I L+ YF WN +F ++++ I+ +F ++ + P +I+L
Sbjct: 1571 VLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLA 1630
Query: 706 VIMGYLRIIR 715
I LR+I+
Sbjct: 1631 RIGRILRLIK 1640
Score = 34.3 bits (77), Expect = 0.68
Identities = 54/236 (22%), Positives = 93/236 (39%), Gaps = 58/236 (24%)
Query: 499 ESTTDEALMEEARLHVAAIQMSSFE----KQR--------NNGILEIEAARILIGAAKCY 546
E TT E M + R + M E +QR N + E+E +R C+
Sbjct: 670 EGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQK--CPPCW 727
Query: 547 YSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFHIVFS 606
Y F+ I+D S Y WL K K+V+ + + P + +T
Sbjct: 728 YKFSNIFL-IWDCSPY-----WL-KVKHVVNLV--------VMDPFVDLAITICI----- 767
Query: 607 EEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKY 666
++N ++ M + +PM N + L N F ++ E LKII + Y
Sbjct: 768 --------VLNTLF---MAMEHYPMTDHFN-NVLTVGNLVFTGIFTAEMFLKIIAMDPYY 815
Query: 667 -FQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFK 721
FQ+ WN + FI+ + ++++ LA ++ ++ R++R L K
Sbjct: 816 YFQEGWNIFDGFIVTLSLVEL-----------GLANVEGLSVLRSFRLLRVFKLAK 860
Score = 33.1 bits (74), Expect = 1.5
Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KII + + + WN L+F ++ + FV L
Sbjct: 156 NVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFA----YVTEFVDL-- 209
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 252
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 50.4 bits (119), Expect = 9e-06
Identities = 37/146 (25%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
+P N FIF +V S+ F ++ M+I + +++ AL IN F+
Sbjct: 1233 VPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSI-ALYWINSIFV 1291
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDI---FCVYFVKLRPDNLALIQLT 705
LY +E LK+I + YF WN +F +++ I + V + P + LI L+
Sbjct: 1292 MLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLS 1351
Query: 706 VIMGYLRIIRFLPLF-KIIVPILIRI 730
I+ LR+ + +F +++P+++ +
Sbjct: 1352 RIIHMLRLGKGPKVFHNLMLPLMLSL 1377
Score = 37.0 bits (84), Expect = 0.11
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 16/169 (9%)
Query: 563 MRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLT---FIFHIV---FSEEFEYTGQII 616
+R + L K K + Y K I S +L F+ I+ F++ F I+
Sbjct: 458 LRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIIL 517
Query: 617 NLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRK-YFQQCWNTLE 675
N+ ++ + +PM++ N I N F+ ++ E KII + YFQ WN +
Sbjct: 518 NVCFL---TLEHYPMSKQTNTLLNIG-NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFD 573
Query: 676 FFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIV 724
I+ G+I++ C+ V +AL++L ++ ++ ++ P F+I++
Sbjct: 574 SMIVFHGLIEL-CLANVA----GMALLRLFRMLRIFKLGKYWPTFQILM 617
Score = 33.1 bits (74), Expect = 1.5
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 14/88 (15%)
Query: 647 FMFLYVLESTLKIIILKRK-YFQQCWNTLEFFILVIGIIDIFCVYFV-KLRPDNLALIQL 704
F ++++LE LK + K YF W L+F +++ +FC+ + K R + LI
Sbjct: 975 FTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVI-----VFCLSLIGKTREELKPLIS- 1028
Query: 705 TVIMGYLRIIRFLPLF---KIIVPILIR 729
M +LR +R L F K++V LI+
Sbjct: 1029 ---MKFLRPLRVLSQFERMKVVVRALIK 1053
>gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger),
member 4 [Homo sapiens]
Length = 798
Score = 47.8 bits (112), Expect = 6e-05
Identities = 88/410 (21%), Positives = 174/410 (42%), Gaps = 65/410 (15%)
Query: 59 ILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLII---FMVALDVEFYTLKK 115
+L L G ++G + + + P++ +S + LY P+++ + + F +
Sbjct: 102 LLILVGALVGGIIFGTDHKSP---PVMDSSIYFLY-LLPPIVLEGGYFMPTRPFFENIGS 157
Query: 116 MFWQVLLTGLISFSTASIIIGYV--VIKFNKDSWDLQSCLLFSITLGIIDPLRSVNSLKT 173
+ W +L LI+ + + + V F +L LLF + +DP+ + +
Sbjct: 158 ILWWAVLGALINALGIGLSLYLICQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEE 217
Query: 174 IGISKIYIDLIRGESLIICSIASIF------------FGNFRGNRIHFSIFRDLHVGIEL 221
+++ +I GE+L+ I + F + I R + VG+
Sbjct: 218 ARVNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLG- 276
Query: 222 SYDILGSIIFGYWCAKIIQCILADVFSNMLTNI--ILCFSMVYMTFYIVEFLGMSGTLAL 279
+L I+FG+ A I + F+ ++ I ++ F Y+++ E L +SG LA+
Sbjct: 277 --GVLFGIVFGFISAFITR------FTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAI 328
Query: 280 AAVGLNLDSLTFKPKIE--------LVITKFLRIFSSVYEHLIYAFFGI-VIGCGELSHY 330
A ++T K +E I F+++ SSV E LI+ F G+ +G
Sbjct: 329 TAC-----AVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVG------- 376
Query: 331 EFHTIPFIFILFTTVNLVRLLTILLVSPILMHSN----YEYNWRWGVVITWSGIKGV--F 384
+ H + FI F T+ ++ + V + SN + ++ + +I +SG++G F
Sbjct: 377 KNHEWNWAFICF-TLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSF 435
Query: 385 NLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDL 434
+L + + +L RK +MF+ V+ T+ I + R LD+
Sbjct: 436 SLAFLLPL-SLFPRK----KMFVTATLVVIYFTVFIQGITVGPLVRYLDV 480
>gi|221316609 sperm-associated cation channel 1 [Homo sapiens]
Length = 780
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/105 (27%), Positives = 56/105 (53%), Gaps = 16/105 (15%)
Query: 641 ISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNLA 700
++++ F +YV+E+ LKII L YF WN L+FFI+ + ++D F+ ++ + A
Sbjct: 481 MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLD-----FLLMQTHSFA 535
Query: 701 LIQLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIKKRLSLMYSI 745
+ + + R L +FK L + +++ +RLS + S+
Sbjct: 536 IY-------HQSLFRILKVFK----SLRALRAIRVLRRLSFLTSV 569
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/132 (24%), Positives = 60/132 (45%), Gaps = 8/132 (6%)
Query: 589 IPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFM 648
IP N +F V + F+ ++ + + M++ ++ + + L IN F+
Sbjct: 1504 IPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQME-NILYWINLVFV 1562
Query: 649 FLYVLESTLKIIILKRKYFQQCWNTLEFFILVIGIIDIFCV-----YFVKLRPDNLALIQ 703
+ E LK+ L+ YF WN +F ++++ I+ +F YFV P +I+
Sbjct: 1563 IFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVS--PTLFRVIR 1620
Query: 704 LTVIMGYLRIIR 715
L I LR+I+
Sbjct: 1621 LARIGRILRLIK 1632
Score = 34.3 bits (77), Expect = 0.68
Identities = 29/103 (28%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 642 SINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRP 696
++ Y F +Y ES +KII I + + WN L+F ++++ I FV L
Sbjct: 160 NVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYI----TEFVNL-- 213
Query: 697 DNLALIQLTVIMGYLRIIRFLPLFKIIVPILI----RIADVQI 735
N++ ++ ++ L+ I +P K IV LI +++DV I
Sbjct: 214 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMI 256
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 44.7 bits (104), Expect = 5e-04
Identities = 35/149 (23%), Positives = 67/149 (44%), Gaps = 7/149 (4%)
Query: 573 KNVLTFLEYCIEKI---HFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLW 629
KN +EY ++ +IP N + +++V S FEY ++ ++ + + +
Sbjct: 1170 KNQRQCVEYALKARPLRRYIP--KNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY 1227
Query: 630 PMARGLNVSALISINYYFMFLYVLESTLKIIILKRK-YFQQCWNTLEFFILVIGIIDIFC 688
++ N A+ +N F ++ +E LK+I K K YF WNT + I++ IID+
Sbjct: 1228 EQSKMFN-DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVAL 1286
Query: 689 VYFVKLRPDNLALIQLTVIMGYLRIIRFL 717
N I + +R+++ L
Sbjct: 1287 SEADNSEESNRISITFFRLFRVMRLVKLL 1315
Score = 35.0 bits (79), Expect = 0.40
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 640 LISINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK 693
L + Y F+ ++ +E+ LKII + Y + WN L+F I+++G+ + K
Sbjct: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTK 219
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 44.7 bits (104), Expect = 5e-04
Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)
Query: 644 NYYFMFLYVLESTLKIIIL----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNL 699
++ F+F + +E LK++ L K+ Y WN L+FFI++ G+++ Y + L+ NL
Sbjct: 120 DFIFIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVE----YSLDLQNINL 174
Query: 700 ALIQLTVIMGYLRIIRFLPLFKIIVPILI 728
+ I+ ++ L+ I +P +I+V +L+
Sbjct: 175 SAIRTVRVLRPLKAINRVPSMRILVNLLL 203
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 14/79 (17%)
Query: 644 NYYFMFLYVLESTLKIIIL-----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDN 698
NY F ++V E TLK++ L ++ Y + WN L+ F++ + IIDI +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVV---------S 1223
Query: 699 LALIQLTVIMGYLRIIRFL 717
LA I+G LR++R L
Sbjct: 1224 LASAGGAKILGVLRVLRLL 1242
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 638 SALISINYYFMFLYVLESTLKIIIL-KRKYFQQCWNTLEFFILVIGIIDIFC--VYFVKL 694
+AL NY F ++VLE+ LK++ R++F+ WN L+ I+++ ++ I +
Sbjct: 1482 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1541
Query: 695 RPDNLALIQLTVIMGYLRIIRFLPLFKI 722
P N +I+ IM LRI R L L K+
Sbjct: 1542 LPINPTIIR---IMRVLRIARVLKLLKM 1566
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 44.7 bits (104), Expect = 5e-04
Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)
Query: 644 NYYFMFLYVLESTLKIIIL----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNL 699
++ F+F + +E LK++ L K+ Y WN L+FFI++ G+++ Y + L+ NL
Sbjct: 120 DFIFIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVE----YSLDLQNINL 174
Query: 700 ALIQLTVIMGYLRIIRFLPLFKIIVPILI 728
+ I+ ++ L+ I +P +I+V +L+
Sbjct: 175 SAIRTVRVLRPLKAINRVPSMRILVNLLL 203
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 14/79 (17%)
Query: 644 NYYFMFLYVLESTLKIIIL-----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDN 698
NY F ++V E TLK++ L ++ Y + WN L+ F++ + IIDI +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVV---------S 1258
Query: 699 LALIQLTVIMGYLRIIRFL 717
LA I+G LR++R L
Sbjct: 1259 LASAGGAKILGVLRVLRLL 1277
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 638 SALISINYYFMFLYVLESTLKIIIL-KRKYFQQCWNTLEFFILVIGIIDIFC--VYFVKL 694
+AL NY F ++VLE+ LK++ R++F+ WN L+ I+++ ++ I +
Sbjct: 1517 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
Query: 695 RPDNLALIQLTVIMGYLRIIRFLPLFKI 722
P N +I+ IM LRI R L L K+
Sbjct: 1577 LPINPTIIR---IMRVLRIARVLKLLKM 1601
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 44.3 bits (103), Expect = 7e-04
Identities = 32/89 (35%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 639 ALISINYYFMFLYVLESTLKIIILK-RKYFQQCWNTLEFFILVIGIIDIFC--VYFVKLR 695
AL NY F ++VLES K++ R++FQ WN L+ I+++ I+ I +
Sbjct: 1642 ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASL 1701
Query: 696 PDNLALIQLTVIMGYLRIIRFLPLFKIIV 724
P N +I+ IM LRI R L L K+ V
Sbjct: 1702 PINPTIIR---IMRVLRIARVLKLLKMAV 1727
Score = 40.4 bits (93), Expect = 0.010
Identities = 23/89 (25%), Positives = 50/89 (56%), Gaps = 9/89 (10%)
Query: 644 NYYFMFLYVLESTLKIIIL----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDNL 699
++ F F + +E +K++ L K+ Y WN L+FFI++ G+++ Y + L+ +
Sbjct: 122 DFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE----YSLDLQNVSF 176
Query: 700 ALIQLTVIMGYLRIIRFLPLFKIIVPILI 728
+ ++ ++ LR I +P +I+V +L+
Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLL 205
Score = 39.7 bits (91), Expect = 0.016
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 14/79 (17%)
Query: 644 NYYFMFLYVLESTLKIIIL-----KRKYFQQCWNTLEFFILVIGIIDIFCVYFVKLRPDN 698
NY F +++ E T+K++ L ++ Y + WN L+ +++I +IDI V + D+
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI----LVSMVSDS 1369
Query: 699 LALIQLTVIMGYLRIIRFL 717
T I+G LR++R L
Sbjct: 1370 -----GTKILGMLRVLRLL 1383
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 44.3 bits (103), Expect = 7e-04
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 7/118 (5%)
Query: 573 KNVLTFLEYCIEKI---HFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLW 629
KN +EY ++ +IP N + +++V S FEY ++ ++ + + +
Sbjct: 1170 KNQRQCVEYALKARPLRRYIP--KNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY 1227
Query: 630 PMARGLNVSALISINYYFMFLYVLESTLKIIILKRK-YFQQCWNTLEFFILVIGIIDI 686
++ N A+ +N F ++ +E LK+I K K YF WNT + I++ IID+
Sbjct: 1228 EQSKMFN-DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1284
Score = 35.0 bits (79), Expect = 0.40
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 640 LISINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK 693
L + Y F+ ++ +E+ LKII + Y + WN L+F I+++G+ + K
Sbjct: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTK 219
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 44.3 bits (103), Expect = 7e-04
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 7/118 (5%)
Query: 573 KNVLTFLEYCIEKI---HFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLW 629
KN +EY ++ +IP N + +++V S FEY ++ ++ + + +
Sbjct: 1190 KNQRQCVEYALKARPLRRYIP--KNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY 1247
Query: 630 PMARGLNVSALISINYYFMFLYVLESTLKIIILKRK-YFQQCWNTLEFFILVIGIIDI 686
++ N A+ +N F ++ +E LK+I K K YF WNT + I++ IID+
Sbjct: 1248 EQSKMFN-DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV 1304
Score = 35.0 bits (79), Expect = 0.40
Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 640 LISINYYFMFLYVLESTLKII-----ILKRKYFQQCWNTLEFFILVIGIIDIFCVYFVK 693
L + Y F+ ++ +E+ LKII + Y + WN L+F I+++G+ + K
Sbjct: 161 LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTK 219
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.142 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,871,225
Number of Sequences: 37866
Number of extensions: 1507679
Number of successful extensions: 4433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 4089
Number of HSP's gapped (non-prelim): 343
length of query: 1124
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1011
effective length of database: 13,968,660
effective search space: 14122315260
effective search space used: 14122315260
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.