Search of human proteins with 223942069

Search of human proteins with 223942069

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223942069 enterokinase precursor [Homo sapiens]
         (1019 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223942069 enterokinase precursor [Homo sapiens]                   2120   0.0  
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   247   5e-65
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   247   5e-65
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   246   8e-65
gi|11415040 matriptase [Homo sapiens]                                 243   7e-64
gi|29244926 corin [Homo sapiens]                                      234   4e-61
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   215   2e-55
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         213   1e-54
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   211   3e-54
gi|33695155 hepsin [Homo sapiens]                                     211   4e-54
gi|4504481 hepsin [Homo sapiens]                                      211   4e-54
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             207   3e-53
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           205   2e-52
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          205   2e-52
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          201   3e-51
gi|4503627 coagulation factor XI precursor [Homo sapiens]             196   1e-49
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        195   2e-49
gi|4506153 prostasin preproprotein [Homo sapiens]                     194   3e-49
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           194   4e-49
gi|58218970 protease, serine, 36 [Homo sapiens]                       191   2e-48
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          191   4e-48
gi|32698940 transmembrane protease, serine 12 [Homo sapiens]          185   2e-46
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         184   5e-46
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       184   5e-46
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        182   2e-45
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   177   3e-44
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   177   3e-44
gi|4505881 plasminogen [Homo sapiens]                                 177   6e-44
gi|117956391 protease, serine, 33 [Homo sapiens]                      177   6e-44
gi|110815798 ovochymase 1 [Homo sapiens]                              177   6e-44

>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score = 2120 bits (5494), Expect = 0.0
 Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)

Query: 1    MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA 60
            MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA
Sbjct: 1    MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA 60

Query: 61   TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII 120
            TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII
Sbjct: 61   TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII 120

Query: 121  VVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV 180
            VVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV
Sbjct: 121  VVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV 180

Query: 181  SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA 240
            SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA
Sbjct: 181  SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA 240

Query: 241  THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN 300
            THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN
Sbjct: 241  THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN 300

Query: 301  PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL 360
            PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL
Sbjct: 301  PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL 360

Query: 361  NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP 420
            NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP
Sbjct: 361  NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP 420

Query: 421  ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN 480
            ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN
Sbjct: 421  ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN 480

Query: 481  AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST 540
            AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST
Sbjct: 481  AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST 540

Query: 541  NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG 600
            NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG
Sbjct: 541  NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG 600

Query: 601  PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN 660
            PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN
Sbjct: 601  PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN 660

Query: 661  LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG 720
            LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG
Sbjct: 661  LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG 720

Query: 721  LGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD 780
            LGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD
Sbjct: 721  LGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD 780

Query: 781  ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI 840
            ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI
Sbjct: 781  ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI 840

Query: 841  LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE 900
            LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE
Sbjct: 841  LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE 900

Query: 901  NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE 960
            NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE
Sbjct: 901  NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE 960

Query: 961  EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH 1019
            EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
Sbjct: 961  EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH 1019


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
            sapiens]
          Length = 529

 Score =  247 bits (630), Expect = 5e-65
 Identities = 137/379 (36%), Positives = 204/379 (53%), Gaps = 14/379 (3%)

Query: 643  CKADHFQC-KNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHT 701
            C     +C  +G C+   N CDG  HC  G DE  CVR +    N    V    +  WH 
Sbjct: 150  CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYG--PNFILQVYSSQRKSWHP 207

Query: 702  ACAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGP--FVKLNTAP---DGHLILTPSQQ 756
             C ++W        C+ +G  +   S      D G   F+KLNT+    D +  L  S  
Sbjct: 208  VCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 267

Query: 757  CLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVS 816
            C   +++ L+C   +CG  L +   + +IVGG +A  GAWPW V L+     +CG S+++
Sbjct: 268  CSSKAVVSLRCI--ACGVNLNSSRQS-RIVGGESALPGAWPWQVSLHVQNVHVCGGSIIT 324

Query: 817  SDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDND 876
             +W+V+AAHCV      P  WTA  G+  +S +         +++++ +P+Y+ + K+ND
Sbjct: 325  PEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQ--VEKVISHPNYDSKTKNND 382

Query: 877  IAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLL 936
            IA+M L+  + + D ++P+CLP    +  P + C I+GWG    +G T+ +L  A V L+
Sbjct: 383  IALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLI 442

Query: 937  SNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKC 995
              +RC  +    N IT  MICAG+ +G +DSCQGDSGGPL+  +NN W+L G TS+G  C
Sbjct: 443  ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGC 502

Query: 996  ALPNRPGVYARVSRFTEWI 1014
            A   RPGVY  V  FT+WI
Sbjct: 503  AKAYRPGVYGNVMVFTDWI 521



 Score = 37.7 bits (86), Expect = 0.056
 Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 14/125 (11%)

Query: 183 ECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATH 242
           +C      C  + TCI    +CDG  +CP G DE+   C  +    F+L   S   ++ H
Sbjct: 149 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENR--CVRLYGPNFILQVYSSQRKSWH 206

Query: 243 YPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPG 302
                    VCQ     N G +        N +Y+    I +  GS+  ++ +   T+ G
Sbjct: 207 --------PVCQDDWNENYGRAACRDMGYKNNFYSS-QGIVDDSGSTSFMKLN---TSAG 254

Query: 303 TIRIF 307
            + I+
Sbjct: 255 NVDIY 259


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
            sapiens]
          Length = 492

 Score =  247 bits (630), Expect = 5e-65
 Identities = 137/379 (36%), Positives = 204/379 (53%), Gaps = 14/379 (3%)

Query: 643  CKADHFQC-KNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHT 701
            C     +C  +G C+   N CDG  HC  G DE  CVR +    N    V    +  WH 
Sbjct: 113  CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYG--PNFILQVYSSQRKSWHP 170

Query: 702  ACAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGP--FVKLNTAP---DGHLILTPSQQ 756
             C ++W        C+ +G  +   S      D G   F+KLNT+    D +  L  S  
Sbjct: 171  VCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 230

Query: 757  CLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVS 816
            C   +++ L+C   +CG  L +   + +IVGG +A  GAWPW V L+     +CG S+++
Sbjct: 231  CSSKAVVSLRCI--ACGVNLNSSRQS-RIVGGESALPGAWPWQVSLHVQNVHVCGGSIIT 287

Query: 817  SDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDND 876
             +W+V+AAHCV      P  WTA  G+  +S +         +++++ +P+Y+ + K+ND
Sbjct: 288  PEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQ--VEKVISHPNYDSKTKNND 345

Query: 877  IAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLL 936
            IA+M L+  + + D ++P+CLP    +  P + C I+GWG    +G T+ +L  A V L+
Sbjct: 346  IALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLI 405

Query: 937  SNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKC 995
              +RC  +    N IT  MICAG+ +G +DSCQGDSGGPL+  +NN W+L G TS+G  C
Sbjct: 406  ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGC 465

Query: 996  ALPNRPGVYARVSRFTEWI 1014
            A   RPGVY  V  FT+WI
Sbjct: 466  AKAYRPGVYGNVMVFTDWI 484



 Score = 37.7 bits (86), Expect = 0.056
 Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 14/125 (11%)

Query: 183 ECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATH 242
           +C      C  + TCI    +CDG  +CP G DE+   C  +    F+L   S   ++ H
Sbjct: 112 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENR--CVRLYGPNFILQVYSSQRKSWH 169

Query: 243 YPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPG 302
                    VCQ     N G +        N +Y+    I +  GS+  ++ +   T+ G
Sbjct: 170 --------PVCQDDWNENYGRAACRDMGYKNNFYSS-QGIVDDSGSTSFMKLN---TSAG 217

Query: 303 TIRIF 307
            + I+
Sbjct: 218 NVDIY 222


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sapiens]
          Length = 454

 Score =  246 bits (628), Expect = 8e-65
 Identities = 146/393 (37%), Positives = 213/393 (54%), Gaps = 30/393 (7%)

Query: 637  LGIPEPCKADHFQCKNG-ECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRI 695
            LGI   C    ++C++  +C+ L+  CDG   C+DG DE  CVR        N +++   
Sbjct: 67   LGIHFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRCVR----VGGQNAVLQVFT 121

Query: 696  QSIWHTACAENWTTQISNDVCQLLGLGSGNSSKP--IFSTDGG---PFVKLN-TAPDG-- 747
             + W T C+++W    +N  C  LG  S  SS    + S +G     FV ++   PD   
Sbjct: 122  AASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKV 181

Query: 748  ---HLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYY 804
               H  +   + C    ++ LQC   +CG +   +  + +IVGG+ +    WPW   L +
Sbjct: 182  TALHHSVYVREGCASGHVVTLQCT--ACGHR---RGYSSRIVGGNMSLLSQWPWQASLQF 236

Query: 805  GGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVI 864
             G  LCG S+++  W+++AAHCVY   L P  WT  +GL    +  +P     L+++IV 
Sbjct: 237  QGYHLCGGSVITPLWIITAAHCVYDLYL-PKSWTIQVGLVSLLDNPAPS---HLVEKIVY 292

Query: 865  NPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGT 923
            +  Y  +R  NDIA+M L   + + + IQP+CLP   + FP G+ C  +GWG T    G 
Sbjct: 293  HSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGD 352

Query: 924  TANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEEGGIDSCQGDSGGPLMCQENN 981
             + +L  A VPL+SN+ C  +   Y   I+ +M+CAGY  GG+DSCQGDSGGPL+CQE  
Sbjct: 353  ASPVLNHAAVPLISNKICNHR-DVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR 411

Query: 982  RWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
             W L G TSFG  CA  N+PGVY RV+ F +WI
Sbjct: 412  LWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  243 bits (620), Expect = 7e-64
 Identities = 170/533 (31%), Positives = 251/533 (47%), Gaps = 59/533 (11%)

Query: 522  TDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENIN---- 577
            + CGG   L +   TF+S  +P  YP    C W +     +++++ F+ F L        
Sbjct: 338  SSCGG--RLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAG 395

Query: 578  ----DVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTT 633
                D VEI +GE+        Y G      V S +N++TV   ++      GF A + +
Sbjct: 396  TCPKDYVEI-NGEK--------YCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLS 446

Query: 634  GYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEAD--CVRFFNGTTNNNGLV 691
                   +PC    F C+ G C+     CDG   C D SDE +  C      T  N    
Sbjct: 447  ---YDSSDPCPGQ-FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKN---- 498

Query: 692  RFRIQSIWH----TACAEN----------WTTQISNDVCQLLGLGSGNSSKPIFSTDGGP 737
            +F     W       C +N           T + SN  C                +D   
Sbjct: 499  KFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEAS 558

Query: 738  FVKLNTAP---------DGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGG 788
              K+N            +G  +   + +C          + K C   L +     ++VGG
Sbjct: 559  CPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGG 618

Query: 789  SNAKEGAWPWVVGLYYGGR-LLCGASLVSSDWLVSAAHCVYG----RNLEPSKWTAILGL 843
            ++A EG WPW V L+  G+  +CGASL+S +WLVSAAHC       R  +P++WTA LGL
Sbjct: 619  TDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGL 678

Query: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903
            H +S  ++P    R +  I+ +P +N    D DIA++ LE    Y+  ++PICLP+ + V
Sbjct: 679  HDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHV 738

Query: 904  FPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGG 963
            FP G+   + GWG   Y GT A ILQ+ ++ +++   C+  +P+  IT  M+C G+  GG
Sbjct: 739  FPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ-QITPRMMCVGFLSGG 797

Query: 964  IDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015
            +DSCQGDSGGPL   E + R F AGV S+G  CA  N+PGVY R+  F +WI+
Sbjct: 798  VDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIK 850



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 9/104 (8%)

Query: 537 FSSTNFPNS-YPNLAFCVWILNAQKGKNIQLHFQEFDL----ENINDVVEIRD---GEEA 588
           F++  FP+S YP  A C W L       + L F+ FDL    E  +D+V + +     E 
Sbjct: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287

Query: 589 DSLLLAVYTGPGPVKDVF-STTNRMTVLLITNDVLARGGFKANF 631
            +L+    T P      F S+ N + + LITN      GF+A F
Sbjct: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATF 331



 Score = 33.9 bits (76), Expect = 0.80
 Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 28/127 (22%)

Query: 225 CDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDF---------NTY 275
           C GR  L  + G+F + +YP     ++ C W I V     +K+ F  F          T 
Sbjct: 340 CGGR--LRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTC 397

Query: 276 YTDILDI----YEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATY 331
             D ++I    Y G  S  ++ ++            SN++T  F  +   +D  GF A Y
Sbjct: 398 PKDYVEINGEKYCGERSQFVVTSN------------SNKITVRFHSDQSYTD-TGFLAEY 444

Query: 332 TAFNSSE 338
            +++SS+
Sbjct: 445 LSYDSSD 451



 Score = 33.9 bits (76), Expect = 0.80
 Identities = 17/39 (43%), Positives = 20/39 (51%), Gaps = 5/39 (12%)

Query: 188 SSPCTDALTC-----IKADLFCDGEVNCPDGSDEDNKMC 221
           S PC    TC     I+ +L CDG  +C D SDE N  C
Sbjct: 450 SDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSC 488



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 182 IECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMC 221
           + C   +  C + L   K +  CDG+ +C DGSDE +  C
Sbjct: 565 VTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  234 bits (596), Expect = 4e-61
 Identities = 137/386 (35%), Positives = 202/386 (52%), Gaps = 22/386 (5%)

Query: 643  CKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTA 702
            C+ D  +C N  CV     CDG   C D SDE DCV       +++ L+  R  +  H  
Sbjct: 655  CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHV- 713

Query: 703  CAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGP-FVKLNTAPDG------HLILTPSQ 755
            CA+ W   +S   C+ +GLG  + +K I   +  P ++ L++  +       H +L   Q
Sbjct: 714  CADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQ 773

Query: 756  QCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG-GRLLCGASL 814
             C   S I L C  + CG++ AA+ +  +I+GG  ++ G WPW   L       +CG  L
Sbjct: 774  SCESRSKISLLCTKQDCGRRPAAR-MNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVL 832

Query: 815  VSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTV--PRLIDEIVINPHYNRRR 872
            ++  W+++ AHC  GR    + W  +LG++   NL  P      R +  I+++P Y+R  
Sbjct: 833  IAKKWVLTVAHCFEGRE-NAAVWKVVLGIN---NLDHPSVFMQTRFVKTIILHPRYSRAV 888

Query: 873  KDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANI-LQEA 931
             D DI+++ L   ++ T Y++P+CLP   Q   P   C I GWG   + G      LQE 
Sbjct: 889  VDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG---HMGNKMPFKLQEG 945

Query: 932  DVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTS 990
            +V ++S E CQ       IT  MICAGYE G +DSC GDSGGPL+C++   RW L G+TS
Sbjct: 946  EVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTS 1005

Query: 991  FGYKC-ALPNRPGVYARVSRFTEWIQ 1015
            +G  C +    PGVY+ VS F EWI+
Sbjct: 1006 WGSVCFSKVLGPGVYSNVSYFVEWIK 1031



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 17/37 (45%), Positives = 23/37 (62%)

Query: 641 EPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
           E C   HF+C++G+CV     CDG   C+D SDE +C
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 15/29 (51%), Positives = 21/29 (72%)

Query: 649 QCKNGECVPLVNLCDGHLHCEDGSDEADC 677
           +C+NG+C+P    CDG   C+DGSDE +C
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENC 414



 Score = 37.4 bits (85), Expect = 0.073
 Identities = 14/34 (41%), Positives = 22/34 (64%)

Query: 644 KADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
           + ++F C +G C+P    C+G+  C+D SDEA C
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC 304



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)

Query: 183 ECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMC 221
           EC P    C     C+ A   CDG+ +C D SDE+N  C
Sbjct: 579 ECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGC 616



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 14/35 (40%), Positives = 20/35 (57%)

Query: 643 CKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
           C  + F C  G+C+    +CDG+  C D SDE +C
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340



 Score = 35.0 bits (79), Expect = 0.36
 Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 7/46 (15%)

Query: 197 CIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATH 242
           C+  DL+CDGE +C D SDE +  C T+      +  +S SF   H
Sbjct: 667 CVSRDLWCDGEADCSDSSDEWD--CVTLS-----INVNSSSFLMVH 705



 Score = 34.3 bits (77), Expect = 0.61
 Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 6/46 (13%)

Query: 649 QCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFR 694
           +C +G C+ +  +CDG   C D SDE +C      + ++ GLV  R
Sbjct: 349 RCGDGRCIAMEWVCDGDHDCVDKSDEVNC------SCHSQGLVECR 388



 Score = 34.3 bits (77), Expect = 0.61
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 12/61 (19%)

Query: 158 DLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDED 217
           D + VD  D++  + H        +EC  G         CI +   CDG+ +C DGSDE+
Sbjct: 365 DHDCVDKSDEVNCSCH----SQGLVECRNGQ--------CIPSTFQCDGDEDCKDGSDEE 412

Query: 218 N 218
           N
Sbjct: 413 N 413



 Score = 30.8 bits (68), Expect = 6.8
 Identities = 12/28 (42%), Positives = 15/28 (53%)

Query: 191 CTDALTCIKADLFCDGEVNCPDGSDEDN 218
           C     C+K  + CDG  +CPD  DE N
Sbjct: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKN 651


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sapiens]
          Length = 437

 Score =  215 bits (547), Expect = 2e-55
 Identities = 133/376 (35%), Positives = 198/376 (52%), Gaps = 34/376 (9%)

Query: 656  VPLVNLCDGHLHCEDGSDEADCVRFF-NGTTNNNGLVRFR--IQSI------WHTACAEN 706
            +P   LCDG L C  G DE  CV+ F  G      L + R  +Q +      W +AC +N
Sbjct: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130

Query: 707  WTTQISNDVCQLLGLGSGNSSKPIF-STDGGP-----FVKLNTAPDGHLILTPSQQCLQD 760
            +T  ++   C+ +G     SSKP F + + GP      V++        +   S  CL  
Sbjct: 131  FTEALAETACRQMGY----SSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSG 186

Query: 761  SLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWL 820
            SL+ L C   +CGK L     TP++VGG  A   +WPW V + Y  + +CG S++   W+
Sbjct: 187  SLVSLHC--LACGKSLK----TPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV 240

Query: 821  VSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMM 880
            ++AAHC + ++ +   W    G     +  S      +I  I  NP Y    KDNDIA+M
Sbjct: 241  LTAAHC-FRKHTDVFNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMY---PKDNDIALM 294

Query: 881  HLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNE 939
             L+F + ++  ++PICLP  ++   P     I GWG T    G  ++IL +A V ++ + 
Sbjct: 295  KLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDST 354

Query: 940  RCQ-QQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALP 998
            RC      +  +TE M+CAG  EGG+D+CQGDSGGPLM Q +++W + G+ S+GY C  P
Sbjct: 355  RCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGP 413

Query: 999  NRPGVYARVSRFTEWI 1014
            + PGVY +VS +  WI
Sbjct: 414  STPGVYTKVSAYLNWI 429


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  213 bits (541), Expect = 1e-54
 Identities = 127/363 (34%), Positives = 182/363 (50%), Gaps = 25/363 (6%)

Query: 662  CDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSI--WHTACAENWTTQISNDVCQLL 719
            CDG + C+  SDE  CVRF      +  L++    S   W   C+ NW    S   CQ L
Sbjct: 211  CDGVVDCKLKSDELGCVRF----DWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQL 266

Query: 720  GLGSGNSSKPIFSTDGG---PFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKL 776
            G  S + +  +   D       ++ N+     L      +C     I LQC+H  CG + 
Sbjct: 267  GFESAHRTTEVAHRDFANSFSILRYNSTIQESL---HRSECPSQRYISLQCSH--CGLRA 321

Query: 777  AAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY-GRNLEPS 835
                +T +IVGG+ A +  WPW V L++G   +CG +L+ + W+++AAHC +  R     
Sbjct: 322  ----MTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLE 377

Query: 836  KWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPI 895
             W    G      L    ++     EI+IN +Y     D DIA+M L   +  + +I P 
Sbjct: 378  GWKVYAGTSNLHQLPEAASIA----EIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPA 433

Query: 896  CLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNERCQQQMP-EYNITEN 953
            CLP   Q F     C I G+G T      T+  L+E  V L+  ++C   +  +  +T  
Sbjct: 434  CLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPR 493

Query: 954  MICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEW 1013
            M+CAG   GG DSCQGDSGGPL+C++NNRW+LAGVTS+G  C   N+PGVY +V+    W
Sbjct: 494  MMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPW 553

Query: 1014 IQS 1016
            I S
Sbjct: 554  IYS 556


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
            sapiens]
          Length = 432

 Score =  211 bits (537), Expect = 3e-54
 Identities = 128/370 (34%), Positives = 191/370 (51%), Gaps = 27/370 (7%)

Query: 656  VPLVNLCDGHLHCEDGSDEADCVRFF-NGTTNNNGLVRFR--IQSI------WHTACAEN 706
            +P   LCDG L C  G DE  CV+ F  G      L + R  +Q +      W +AC +N
Sbjct: 71   IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130

Query: 707  WTTQISNDVCQLLGLGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQ 766
            +T  ++   C+ +G        P    D    V++        +   S  CL  SL+ L 
Sbjct: 131  FTEALAETACRQMGYSRAVEIGPDQDLD---VVEITENSQELRMRNSSGPCLSGSLVSLH 187

Query: 767  CNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHC 826
            C   +CGK L     TP++VGG  A   +WPW V + Y  + +CG S++   W+++AAHC
Sbjct: 188  C--LACGKSLK----TPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC 241

Query: 827  VYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKV 886
             + ++ +   W    G     +  S      +I  I  NP Y    KDNDIA+M L+F +
Sbjct: 242  -FRKHTDVFNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMY---PKDNDIALMKLQFPL 295

Query: 887  NYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNERCQ-QQ 944
             ++  ++PICLP  ++   P     I GWG T    G  ++IL +A V ++ + RC    
Sbjct: 296  TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 355

Query: 945  MPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVY 1004
              +  +TE M+CAG  EGG+D+CQGDSGGPLM Q +++W + G+ S+GY C  P+ PGVY
Sbjct: 356  AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ-SDQWHVVGIVSWGYGCGGPSTPGVY 414

Query: 1005 ARVSRFTEWI 1014
             +VS +  WI
Sbjct: 415  TKVSAYLNWI 424


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  211 bits (536), Expect = 4e-54
 Identities = 108/256 (42%), Positives = 145/256 (56%), Gaps = 17/256 (6%)

Query: 770  KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYG 829
            + CG++    D   +IVGG +   G WPW V L Y G  LCG SL+S DW+++AAHC   
Sbjct: 151  QDCGRRKLPVD---RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE 207

Query: 830  RNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHY------NRRRKDNDIAMMHLE 883
            RN   S+W    G   ++   SP  +   +  +V +  Y      N     NDIA++HL 
Sbjct: 208  RNRVLSRWRVFAGAVAQA---SPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLS 264

Query: 884  FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQ- 942
              +  T+YIQP+CLP   Q    G+ C++ GWG   Y G  A +LQEA VP++SN+ C  
Sbjct: 265  SPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNG 324

Query: 943  QQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQEN----NRWFLAGVTSFGYKCALP 998
                   I   M CAGY EGGID+CQGDSGGP +C+++     RW L G+ S+G  CAL 
Sbjct: 325  ADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384

Query: 999  NRPGVYARVSRFTEWI 1014
             +PGVY +VS F EWI
Sbjct: 385  QKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  211 bits (536), Expect = 4e-54
 Identities = 108/256 (42%), Positives = 145/256 (56%), Gaps = 17/256 (6%)

Query: 770  KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYG 829
            + CG++    D   +IVGG +   G WPW V L Y G  LCG SL+S DW+++AAHC   
Sbjct: 151  QDCGRRKLPVD---RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE 207

Query: 830  RNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHY------NRRRKDNDIAMMHLE 883
            RN   S+W    G   ++   SP  +   +  +V +  Y      N     NDIA++HL 
Sbjct: 208  RNRVLSRWRVFAGAVAQA---SPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLS 264

Query: 884  FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQ- 942
              +  T+YIQP+CLP   Q    G+ C++ GWG   Y G  A +LQEA VP++SN+ C  
Sbjct: 265  SPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNG 324

Query: 943  QQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQEN----NRWFLAGVTSFGYKCALP 998
                   I   M CAGY EGGID+CQGDSGGP +C+++     RW L G+ S+G  CAL 
Sbjct: 325  ADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384

Query: 999  NRPGVYARVSRFTEWI 1014
             +PGVY +VS F EWI
Sbjct: 385  QKPGVYTKVSDFREWI 400


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  207 bits (528), Expect = 3e-53
 Identities = 98/234 (41%), Positives = 147/234 (62%), Gaps = 5/234 (2%)

Query: 784  KIVGGSNAKEGAWPWVVGLYY---GGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI 840
            +IVGG+N+  G WPW V L       R LCG SL+   W+++AAHC  G  L+   W   
Sbjct: 390  RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQ-DVWRIY 448

Query: 841  LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE 900
             G+   S++T      + I EI+I+ +Y     ++DIA++ L+  +NYT++ +PICLP +
Sbjct: 449  SGILNLSDITKDTPFSQ-IKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSK 507

Query: 901  NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE 960
                    NC + GWG    +G   NILQ+ ++PL++NE CQ++  +Y IT+ M+CAGY+
Sbjct: 508  GDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYK 567

Query: 961  EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
            EGG D+C+GDSGGPL+C+ N  W L G+TS+G  CA   +PGVY +V+ + +WI
Sbjct: 568  EGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  205 bits (522), Expect = 2e-52
 Identities = 134/413 (32%), Positives = 195/413 (47%), Gaps = 47/413 (11%)

Query: 621  VLARGGFKANFTTGYHLGIP------------EPCKADHFQCKNGECVPLVNLCDGHLHC 668
            V+A  G   NFT+   L  P            +PC  +     NG CVP    CDG   C
Sbjct: 424  VVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPA---CDGVKDC 480

Query: 669  EDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVC--QLLGLGSGNS 726
             +G DE +CV             R   Q      C E+ T      VC  Q   L   + 
Sbjct: 481  PNGLDERNCV------------CRATFQ------CKEDSTCISLPKVCDGQPDCLNGSDE 522

Query: 727  SKPIFSTDGGPFVKLNTAPDGHLILTPSQQC--LQDSLIRLQCNHKSCGKKLAAQDITPK 784
             +       G F       D   +  P+ QC    D        H  CG     Q  + +
Sbjct: 523  EQCQEGVPCGTFTF--QCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCG----LQGPSSR 576

Query: 785  IVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSK-WTAILGL 843
            IVGG+ + EG WPW   L   GR +CG +L++  W+++AAHC    ++  +  WT  LG 
Sbjct: 577  IVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLG- 635

Query: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903
             +  N   P  V   +  ++++P++     D D+A++ L+  V  +  ++P+CLP  +  
Sbjct: 636  KVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHF 695

Query: 904  FPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGG 963
            F PG +C I GWG +   G  +N LQ+ DV L+  + C  ++  Y +T  M+CAGY +G 
Sbjct: 696  FEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLC-SEVYRYQVTPRMLCAGYRKGK 754

Query: 964  IDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015
             D+CQGDSGGPL+C+  + RWFLAG+ S+G  C  PN  GVY R++    WIQ
Sbjct: 755  KDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQ 807



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 4/43 (9%)

Query: 179 NVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMC 221
           N S  C PG   C+    C+ A   CDG  +CP+G DE N +C
Sbjct: 453 NQSDPC-PGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVC 491



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 12/27 (44%), Positives = 17/27 (62%)

Query: 191 CTDALTCIKADLFCDGEVNCPDGSDED 217
           C +  TCI     CDG+ +C +GSDE+
Sbjct: 497 CKEDSTCISLPKVCDGQPDCLNGSDEE 523


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  205 bits (522), Expect = 2e-52
 Identities = 115/331 (34%), Positives = 173/331 (52%), Gaps = 18/331 (5%)

Query: 694  RIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFSTD-----GGPFVKLNTAPDGH 748
            R Q  W   C E W+  +   +C  LG       K +  TD        F +L+    G 
Sbjct: 126  RDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGF 185

Query: 749  L--ILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGG 806
            L     P   C    ++ L+C+   CG    A+ +  +IVGG +   G WPW   +  G 
Sbjct: 186  LEEAWQPRNNCTSGQVVSLRCSE--CG----ARPLASRIVGGQSVAPGRWPWQASVALGF 239

Query: 807  RLLCGASLVSSDWLVSAAHCVYGRNLEP-SKWTAILGLHMKSNLTSPQTVPRLIDEIVIN 865
            R  CG S+++  W+V+AAHC++   L   S W    GL   S +   Q    L++ I+ +
Sbjct: 240  RHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGA--LVERIIPH 297

Query: 866  PHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGT-T 924
            P Y+ +  D D+A++ L+  +N++D +  +CLP + Q FP G  C ++GWG      T +
Sbjct: 298  PLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYS 357

Query: 925  ANILQEADVPLLSNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMCQENNRW 983
            +++LQ+  VPL S + C         +T  M+CAGY +G  D+CQGDSGGPL+C + + W
Sbjct: 358  SDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTW 417

Query: 984  FLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
             L GV S+G  CA PN PGVYA+V+ F +WI
Sbjct: 418  RLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  201 bits (511), Expect = 3e-51
 Identities = 135/401 (33%), Positives = 191/401 (47%), Gaps = 62/401 (15%)

Query: 639  IPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVR-----FFNGTTNNNGLV-- 691
            I +PC    F+C +G CVP    CDG   C D SDE  CV        +    +  L+  
Sbjct: 354  ISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICD 413

Query: 692  RFRI-------QSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGPFVKLNTA 744
             FR        Q+   +    N T +  ND+C                     F K N  
Sbjct: 414  GFRDCENGRDEQNCTQSIPCNNRTFKCGNDIC---------------------FRKQNAK 452

Query: 745  PDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYY 804
             DG +       C  D      C   +C +  +A     +I+GG++  EG WPW V L++
Sbjct: 453  CDGTV------DC-PDGSDEEGC---TCSRSSSALH---RIIGGTDTLEGGWPWQVSLHF 499

Query: 805  GGRLLCGASLVSSDWLVSAAHCVYGRNL-EPSKWTAILGLHMKSNLTSPQTVPRLIDEIV 863
             G   CGAS++S +WL+SAAHC +G  L +P+ WTA LG++++ N      V R    IV
Sbjct: 500  VGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRR----IV 555

Query: 864  INPHYNRRRKDNDIAMMHLEFKVNYT--DYIQPICLPEENQVFPPGRNCSIAGWGTVVYQ 921
            ++ +YN +  D DIA++ L      T    IQPIC+P   Q    G  C + GWG     
Sbjct: 556  VHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEA 615

Query: 922  GTTAN-ILQEADVPLLSNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMC-- 977
                + +LQ+A+V L+    C   +  Y  IT  M+CAG   G  D+C+GDSGGPL C  
Sbjct: 616  DNKGSLVLQQAEVELIDQTLC---VSTYGIITSRMLCAGIMSGKRDACKGDSGGPLSCRR 672

Query: 978  QENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFL 1018
            + + +W L G+ S+G+    PN PGVY RVS F  WI  ++
Sbjct: 673  KSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYV 713



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 18/59 (30%), Positives = 29/59 (49%)

Query: 181 SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQ 239
           SI C   +  C + +   K +  CDG V+CPDGSDE+   C+        + G + + +
Sbjct: 430 SIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLE 488


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  196 bits (497), Expect = 1e-49
 Identities = 98/237 (41%), Positives = 136/237 (57%), Gaps = 5/237 (2%)

Query: 781  ITPKIVGGSNAKEGAWPWVVGLYYGG---RLLCGASLVSSDWLVSAAHCVYGRNLEPSKW 837
            I P+IVGG+ +  G WPW V L+      R LCG S++ + W+++AAHC YG  +E  K 
Sbjct: 384  IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG--VESPKI 441

Query: 838  TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICL 897
              +    +  +     T    + EI+I+  Y       DIA++ LE  VNYTD  +PICL
Sbjct: 442  LRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501

Query: 898  PEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICA 957
            P +        +C + GWG    +    N LQ+A +PL++NE CQ++   + IT  MICA
Sbjct: 502  PSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICA 561

Query: 958  GYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
            GY EGG D+C+GDSGGPL C+ N  W L G+TS+G  CA   RPGVY  V  + +WI
Sbjct: 562  GYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  195 bits (496), Expect = 2e-49
 Identities = 100/271 (36%), Positives = 162/271 (59%), Gaps = 11/271 (4%)

Query: 751  LTPSQQCLQDSLIRLQCNHK--SCGKKLAAQDITPKIVGG-SNAKEGAWPWVVGLYY-GG 806
            LTP       +L+  +C  +  S    L A   T +IV G   A EG WPW   L   G 
Sbjct: 170  LTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGS 229

Query: 807  RLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINP 866
               CGASL+S+ WL++AAHC + +N +P++W A  G  +     +P  V R + +I+++ 
Sbjct: 230  GHQCGASLISNTWLLTAAHCFW-KNKDPTQWIATFGATI-----TPPAVKRNVRKIILHE 283

Query: 867  HYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTAN 926
            +Y+R   +NDIA++ L   V +++ +Q +CLP+ +   PP  +  + G+G++V  G   N
Sbjct: 284  NYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQN 343

Query: 927  ILQEADVPLLSNERCQQQ-MPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL 985
             L++A V  +S + C ++ + +  IT  M+CAG+ EG ID+C+GDSGGPL+   ++ W++
Sbjct: 344  TLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYI 403

Query: 986  AGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016
             G+ S+G  CALP +PGVY RV+++ +WI S
Sbjct: 404  VGIVSWGQSCALPKKPGVYTRVTKYRDWIAS 434


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  194 bits (494), Expect = 3e-49
 Identities = 101/242 (41%), Positives = 138/242 (57%), Gaps = 11/242 (4%)

Query: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGL 843
            +I GGS+A  G WPW V + Y G  +CG SLVS  W++SAAHC    + + + +   LG 
Sbjct: 44   RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEA-YEVKLGA 102

Query: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903
            H   + +    V  L D I+ +P Y +     DIA++ L   + ++ YI+PICLP  N  
Sbjct: 103  HQLDSYSEDAKVSTLKD-IIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANAS 161

Query: 904  FPPGRNCSIAGWGTVVYQGT--TANILQEADVPLLSNERCQ-----QQMPE--YNITENM 954
            FP G +C++ GWG V    +  T   LQ+ +VPL+S E C         PE  + + E+M
Sbjct: 162  FPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDM 221

Query: 955  ICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
            +CAGY EGG D+CQGDSGGPL C     W+L G+ S+G  C   NRPGVY   S +  WI
Sbjct: 222  VCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWI 281

Query: 1015 QS 1016
            QS
Sbjct: 282  QS 283


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  194 bits (493), Expect = 4e-49
 Identities = 102/248 (41%), Positives = 149/248 (60%), Gaps = 6/248 (2%)

Query: 769  HKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY 828
            H  CG + A + +  +IVGG  A  G +PW   L       CGA+++++ WLVSAAHC +
Sbjct: 188  HCECGLQPAWR-MAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHC-F 245

Query: 829  GRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888
                +P+KW A +G    S  +   TV   + +IV +P YN    D D+A++ L   + +
Sbjct: 246  NEFQDPTKWVAYVGATYLSG-SEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPF 304

Query: 889  TDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQG-TTANILQEADVPLLSNERCQQQMPE 947
              +IQP+CLP    +FPP + C I+GWG +         +LQ+A V LL    C   +  
Sbjct: 305  GRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC-ASLYG 363

Query: 948  YNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYAR 1006
            +++T+ M+CAGY +G +DSCQGDSGGPL+C+E + R+FLAG+ S+G  CA   RPGVYAR
Sbjct: 364  HSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYAR 423

Query: 1007 VSRFTEWI 1014
            V+R  +WI
Sbjct: 424  VTRLRDWI 431



 Score =  189 bits (481), Expect = 9e-48
 Identities = 109/247 (44%), Positives = 142/247 (57%), Gaps = 14/247 (5%)

Query: 772  CGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRL-LCGASLVSSDWLVSAAHC--VY 828
            CG   AA     +IVGGS A  G WPW V L+   R   CGA LV+  WL+SAAHC  VY
Sbjct: 817  CGLAPAA---LTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVY 873

Query: 829  GRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888
            G   +P +W A LG      L+  +     +  I  +P YN    D D+A++ L   V  
Sbjct: 874  G---DPKQWAAFLGTPF---LSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRR 927

Query: 889  TDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEY 948
            +  ++PICLPE     P G  C I GWG+V   G+ A  LQ+A V LLS + C++  P  
Sbjct: 928  SRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYP-V 986

Query: 949  NITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARV 1007
             I+  M+CAG+ +GG+DSC GD+GGPL C+E + RW L GVTS+GY C  P+ PGVY RV
Sbjct: 987  QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV 1046

Query: 1008 SRFTEWI 1014
            +    WI
Sbjct: 1047 AAVRGWI 1053



 Score =  181 bits (459), Expect = 3e-45
 Identities = 117/330 (35%), Positives = 171/330 (51%), Gaps = 20/330 (6%)

Query: 699  WHTACAENWTTQISNDVCQLLGL---GSGNSSKPIFST----DGGPFVKLNTAPDGHLIL 751
            W   CAE     +   V +L       +  +S P+  T       P     T+P+  ++ 
Sbjct: 408  WGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVS 467

Query: 752  TPSQQCLQDSLIRLQC----NHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGR 807
            TP++     S + L        + CG + A +  T ++VGG  A  G  PW V L  G R
Sbjct: 468  TPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPT-RVVGGFGAASGEVPWQVSLKEGSR 526

Query: 808  LLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLT-SPQTVPRLIDEIVINP 866
              CGA++V   WL+SAAHC     +E  +  A LG      L  SP  +   +  +V++P
Sbjct: 527  HFCGATVVGDRWLLSAAHCFNHTKVEQVR--AHLGTASLLGLGGSPVKIG--LRRVVLHP 582

Query: 867  HYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTA 925
             YN    D D+A++ L   + +  YIQP+CLP   Q FP GR C I+GWG T     T  
Sbjct: 583  LYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKP 642

Query: 926  NILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWF 984
             +LQ+A V ++  + C   +  +++T+ MICAG+ EG +DSCQGDSGGPL C+E    ++
Sbjct: 643  ELLQKASVGIIDQKTC-SVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFY 701

Query: 985  LAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
            LAG+ S+G  CA   +PGVY R++R   WI
Sbjct: 702  LAGIVSWGIGCAQVKKPGVYTRITRLKGWI 731



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 1/36 (2%)

Query: 643 CKADHFQCKNGECVPLVNL-CDGHLHCEDGSDEADC 677
           C  + F C N +CV  VN  CD    C DGSDEA C
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  191 bits (486), Expect = 2e-48
 Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 21/282 (7%)

Query: 749  LILTPSQQCLQDSLI---RLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG 805
            L+++P     QDS +   + +     CG+     + + +IVGGSNA+ G WPW V L++G
Sbjct: 12   LVISPIPGAFQDSALSPTQEEPEDLDCGRP----EPSARIVGGSNAQPGTWPWQVSLHHG 67

Query: 806  GRLLCGASLVSSDWLVSAAHC-VYGRNLEPS-KWTAILGLHMKSN-LTSPQTVPRLIDEI 862
            G  +CG SL++  W++SAAHC +    LEP+ +W+ +LG+H +   L    T  R +  I
Sbjct: 68   GGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHT--RAVAAI 125

Query: 863  VINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQG 922
            V+  +Y++     D+A++ L    +    + P+CLP  +  F  G  C   GWG V    
Sbjct: 126  VVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEAD 185

Query: 923  TTAN--ILQEADVPLLSNERCQ---QQMPEYNIT----ENMICAGYEEGGIDSCQGDSGG 973
                  +LQE ++ LL    CQ    Q   +N+T      M+CAGY EG  D+CQGDSGG
Sbjct: 186  PLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGG 245

Query: 974  PLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015
            PL+C+E  RWF AG+TSFG+ C   NRPGV+  V+ +  WI+
Sbjct: 246  PLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIR 287



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 70/245 (28%), Positives = 101/245 (41%), Gaps = 38/245 (15%)

Query: 788  GSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSK------WTAIL 841
            G   + GAWPW   +   G   C  +LVS  W+++ A C    N   S       W  +L
Sbjct: 326  GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385

Query: 842  GLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKD-NDIAMMHLEFKVNYTDYIQPICLPEE 900
                ++     + V RL+       H N    + +D+A++ L   VN +   +P+CLP  
Sbjct: 386  PSRPRA-----ERVARLVQ------HENASWDNASDLALLQLRTPVNLSAASRPVCLPHP 434

Query: 901  NQVFPPGRNCSIAGWGTVVYQGTTA---NILQEADVPLLSNERCQ-------QQMPEYNI 950
               F PG  C +A WG    +G  A     L EA+  LL    C          +P    
Sbjct: 435  EHYFLPGSRCRLARWG----RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488

Query: 951  TENMICAGYEE-GGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSR 1009
              + +C  Y+E   + SC  DS   L+CQE   WFLAG+  F   C    RP  +  +  
Sbjct: 489  PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQT 545

Query: 1010 FTEWI 1014
               WI
Sbjct: 546  HGPWI 550



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 32/230 (13%)

Query: 769 HKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY 828
           H +CG +L A  +              WPW+  ++  G  +C   L++  W+++A HCV 
Sbjct: 585 HGACGLRLEAAPVGV-----------LWPWLAEVHVAGDRVCTGILLAPGWVLAATHCV- 632

Query: 829 GRNLEPSKWT-----AILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLE 883
              L P   T       LG    S+L     V RL+  I +  H   R     +A++ L 
Sbjct: 633 ---LRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLR---PPLALLELS 686

Query: 884 FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ 943
            +V  +    PICL       PPG +C + GW     +     +   A V +L+   C  
Sbjct: 687 SRVEPSPSALPICLHPAG--IPPGASCWVLGW-----KEPQDRVPVAAAVSILTQRIC-D 738

Query: 944 QMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLAGVTSFG 992
            + +  +    +C  Y EG  + C+  S  PL+CQ     W L G+   G
Sbjct: 739 CLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  191 bits (484), Expect = 4e-48
 Identities = 118/354 (33%), Positives = 180/354 (50%), Gaps = 54/354 (15%)

Query: 669  EDGSD-EADCVRFFNGTTNNNGL-VRFRIQSIWHTACAENWTTQI--SNDVCQLLGLGSG 724
            +DGS   AD V  F  T NNNG  ++ RI+S+       +   +I  S ++  L    + 
Sbjct: 107  QDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAA 166

Query: 725  NSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPK 784
            N               +N    G  ++T S+Q                           +
Sbjct: 167  NWL-------------INECGAGPDLITLSEQ---------------------------R 186

Query: 785  IVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLH 844
            I+GG+ A+EG+WPW V L       CG SL+++ W+++AAHC +  N  P  W A  G+ 
Sbjct: 187  ILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHC-FRSNSNPRDWIATSGI- 244

Query: 845  MKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVF 904
               + T P+   R +  I+I+ +Y     +NDIA++ LE  V +T  I  +CLP   Q  
Sbjct: 245  ---STTFPKLRMR-VRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI 300

Query: 905  PPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEEG 962
            PPG    + GWG   Y G T   L++  V ++SN+ C      YN  I   M+CAG  +G
Sbjct: 301  PPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAP-HSYNGAILSGMLCAGVPQG 359

Query: 963  GIDSCQGDSGGPLMCQENNR-WFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015
            G+D+CQGDSGGPL+ +++ R WF+ G+ S+G +C LP++PGVY RV+ + +WI+
Sbjct: 360  GVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIR 413



 Score = 35.0 bits (79), Expect = 0.36
 Identities = 23/113 (20%), Positives = 57/113 (50%), Gaps = 10/113 (8%)

Query: 7   ISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITS 66
           ++S    L+ Y + F  +  ++++     + V  L   +        +S+  R++F++ +
Sbjct: 7   VTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQ--------KSYFYRSSFQLLN 58

Query: 67  GVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQF-ENGS 118
            V YN  L    + +++ L+  ++ +I + F  SNL+N++  + V +  ++GS
Sbjct: 59  -VEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGS 110


>gi|32698940 transmembrane protease, serine 12 [Homo sapiens]
          Length = 348

 Score =  185 bits (470), Expect = 2e-46
 Identities = 102/245 (41%), Positives = 143/245 (58%), Gaps = 11/245 (4%)

Query: 784  KIVGGSNAKEGAWPWVVGLYYG-GRLL---CGASLVSSDWLVSAAHCVYGRNLEPSKWTA 839
            +I+GG+ A+ GAWPWVV L    GR+L   CG +LV   W+++AAHC    + +P  WTA
Sbjct: 77   RIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDAS-DPLMWTA 135

Query: 840  ILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLP- 898
            ++G +   +   P T    I  I+I+P++      NDIA+ HL+  V Y DYIQPICLP 
Sbjct: 136  VIGTN-NIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPF 194

Query: 899  EENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITEN-MICA 957
            +  Q+      C I+GWG    +G   NILQ+A+V  +S E C  +     I  N   CA
Sbjct: 195  DVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCA 254

Query: 958  GYEEGGIDSCQGDSGGPLMC--QENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI- 1014
            G E+G  D+C+GDSGGPLMC   E  R+F+ G+TS+G+ C     PGVY   S + +W+ 
Sbjct: 255  GDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLT 314

Query: 1015 QSFLH 1019
            + F H
Sbjct: 315  EHFFH 319


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 5e-46
 Identities = 94/236 (39%), Positives = 139/236 (58%), Gaps = 10/236 (4%)

Query: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGL 843
            +IVGG+  +EG WPW   L + G   CGA+L+++ WLVSAAHC +     P++WTA  G+
Sbjct: 191  RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHC-FTTYKNPARWTASFGV 249

Query: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903
             +K     P  + R +  I+++  Y     D DI++  L   V YT+ +  +CLP+ +  
Sbjct: 250  TIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304

Query: 904  FPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEE 961
            F PG    + G+G +   G + N L++A V L+    C +    YN  IT  M+CAG  E
Sbjct: 305  FQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQ-AYNDAITPRMLCAGSLE 363

Query: 962  GGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016
            G  D+CQGDSGGPL+  +  + W+LAG+ S+G +CA PN+PGVY RV+   +WI S
Sbjct: 364  GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITS 419


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  184 bits (466), Expect = 5e-46
 Identities = 94/236 (39%), Positives = 139/236 (58%), Gaps = 10/236 (4%)

Query: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGL 843
            +IVGG+  +EG WPW   L + G   CGA+L+++ WLVSAAHC +     P++WTA  G+
Sbjct: 191  RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHC-FTTYKNPARWTASFGV 249

Query: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQV 903
             +K     P  + R +  I+++  Y     D DI++  L   V YT+ +  +CLP+ +  
Sbjct: 250  TIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304

Query: 904  FPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEE 961
            F PG    + G+G +   G + N L++A V L+    C +    YN  IT  M+CAG  E
Sbjct: 305  FQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQ-AYNDAITPRMLCAGSLE 363

Query: 962  GGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016
            G  D+CQGDSGGPL+  +  + W+LAG+ S+G +CA PN+PGVY RV+   +WI S
Sbjct: 364  GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITS 419


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  182 bits (461), Expect = 2e-45
 Identities = 95/248 (38%), Positives = 141/248 (56%), Gaps = 9/248 (3%)

Query: 772  CGKKLAAQDITP-KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGR 830
            CG+++A   IT  KIV G ++ EGAWPW   + + GR  CGASL+SS WL+SAAHC   +
Sbjct: 171  CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230

Query: 831  NLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTD 890
            N     WT   G+     + +   + R +  I+ + +Y+     +DIA++ L  +V++T+
Sbjct: 231  N-NSKDWTVNFGI-----VVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTE 284

Query: 891  YIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYN- 949
            YI+ ICLPE         N  + GWGT+   G+   ILQE  + ++ N+ C         
Sbjct: 285  YIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGF 344

Query: 950  ITENMICAGYEEGGIDSCQGDSGGPLMCQEN-NRWFLAGVTSFGYKCALPNRPGVYARVS 1008
            +T+ M+CAG+  G  D+CQ DSGGPL   ++ N W L G+ S+G  C   N+PGVY RV+
Sbjct: 345  VTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVT 404

Query: 1009 RFTEWIQS 1016
             +  WI S
Sbjct: 405  SYRNWITS 412



 Score = 34.7 bits (78), Expect = 0.47
 Identities = 36/129 (27%), Positives = 64/129 (49%), Gaps = 8/129 (6%)

Query: 29  VVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFD 88
           + +  G+ A+  +TI       A+ +++  +  F I SGVTYN N ++  S     L+ D
Sbjct: 18  IFIFLGVAAILGVTIGLLVHFLAVEKTYYYQGDFHI-SGVTYNDNCENAASQASTNLSKD 76

Query: 89  LQQMIDEIFLSSNLKNEYKNSRVLQF---ENGSII---VVFDLFFAQWVS-DENVKEELI 141
           ++  +   F +S++  EY  S V++     NGS +   + F    A+ VS    +K +L 
Sbjct: 77  IETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKFKFPPAEGVSMRTKIKAKLH 136

Query: 142 QGLEANKSS 150
           Q L+ N +S
Sbjct: 137 QMLKNNMAS 145


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
            sapiens]
          Length = 418

 Score =  177 bits (450), Expect = 3e-44
 Identities = 91/248 (36%), Positives = 145/248 (58%), Gaps = 9/248 (3%)

Query: 771  SCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGR 830
            SCGK++   ++  +I  G  A + AWPW   L Y     CGA+L+S+ WLV+AAHC + +
Sbjct: 174  SCGKRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHC-FQK 231

Query: 831  NLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTD 890
               P +WT   G  +     +P  + R +   +I+  Y    ++ DIA++ +  +V ++D
Sbjct: 232  YKNPHQWTVSFGTKI-----NPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 286

Query: 891  YIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ-QMPEYN 949
             I+ ICLPE +  F P     I G+G + Y G + N L+EA V ++S++ C+Q Q+   +
Sbjct: 287  DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 346

Query: 950  ITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVS 1008
            I   M CAGY EG  D+C+GDSGGPL+ ++  + W+L G+ S+G  C   ++PGVY +V+
Sbjct: 347  IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 406

Query: 1009 RFTEWIQS 1016
             +  WI S
Sbjct: 407  YYRNWIAS 414



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 8/167 (4%)

Query: 24  LFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEA-RATFKITSGVTYNPNLQDKLSVDF 82
           + A+L+VL   ++AV   TI          Q  E    +FKI      N N     +   
Sbjct: 19  MIAVLIVLSLTVVAV---TIGLLVHFLVFDQKKEYYHGSFKILDP-QINNNFGQSNTYQL 74

Query: 83  KVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQF---ENGSIIVVFDLFFAQWVSDENVKEE 139
           K L    + ++DEIF+ S  K  Y  ++V++    E+G  + V  +F         V+E+
Sbjct: 75  KDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK 134

Query: 140 LIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLP 186
            IQ +   K   L    I+ +SV +    ++T  L    +     +P
Sbjct: 135 KIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVVP 181


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
            sapiens]
          Length = 421

 Score =  177 bits (450), Expect = 3e-44
 Identities = 91/248 (36%), Positives = 145/248 (58%), Gaps = 9/248 (3%)

Query: 771  SCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGR 830
            SCGK++   ++  +I  G  A + AWPW   L Y     CGA+L+S+ WLV+AAHC + +
Sbjct: 177  SCGKRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHC-FQK 234

Query: 831  NLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTD 890
               P +WT   G  +     +P  + R +   +I+  Y    ++ DIA++ +  +V ++D
Sbjct: 235  YKNPHQWTVSFGTKI-----NPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 289

Query: 891  YIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ-QMPEYN 949
             I+ ICLPE +  F P     I G+G + Y G + N L+EA V ++S++ C+Q Q+   +
Sbjct: 290  DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 349

Query: 950  ITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPGVYARVS 1008
            I   M CAGY EG  D+C+GDSGGPL+ ++  + W+L G+ S+G  C   ++PGVY +V+
Sbjct: 350  IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 409

Query: 1009 RFTEWIQS 1016
             +  WI S
Sbjct: 410  YYRNWIAS 417



 Score = 34.3 bits (77), Expect = 0.61
 Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 3/109 (2%)

Query: 81  DFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQF---ENGSIIVVFDLFFAQWVSDENVK 137
           D +    +L   +DEIF+ S  K  Y  ++V++    E+G  + V  +F         V+
Sbjct: 76  DLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVR 135

Query: 138 EELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLP 186
           E+ IQ +   K   L    I+ +SV +    ++T  L    +     +P
Sbjct: 136 EKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVVP 184


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  177 bits (448), Expect = 6e-44
 Identities = 110/284 (38%), Positives = 152/284 (53%), Gaps = 20/284 (7%)

Query: 745  PDGHL----ILTPSQQCLQDSLIRLQCNHKS--CGKKLAAQDITP-KIVGGSNAKEGAWP 797
            PDG +      T + + L D     QC   S  CGK        P ++VGG  A   +WP
Sbjct: 534  PDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWP 593

Query: 798  WVVGLYYG-GRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVP 856
            W V L    G   CG +L+S +W+++AAHC+  ++  PS +  ILG H + NL  P    
Sbjct: 594  WQVSLRTRFGMHFCGGTLISPEWVLTAAHCLE-KSPRPSSYKVILGAHQEVNL-EPHVQE 651

Query: 857  RLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG 916
              +  + + P     RKD  IA++ L      TD + P CLP  N V      C I GWG
Sbjct: 652  IEVSRLFLEP----TRKD--IALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWG 705

Query: 917  TVVYQGTT-ANILQEADVPLLSNERCQQ-QMPEYNITENMICAGYEEGGIDSCQGDSGGP 974
                QGT  A +L+EA +P++ N+ C + +     +    +CAG+  GG DSCQGDSGGP
Sbjct: 706  ET--QGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGP 763

Query: 975  LMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFL 1018
            L+C E +++ L GVTS+G  CA PN+PGVY RVSRF  WI+  +
Sbjct: 764  LVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVM 807


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  177 bits (448), Expect = 6e-44
 Identities = 97/274 (35%), Positives = 149/274 (54%), Gaps = 17/274 (6%)

Query: 757  CLQDSLIRLQCNHKSCGKKLAA---QDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGAS 813
            CLQ  L+ +     + G+K AA     ++ +IVGG + ++G WPW   + + G  +CG S
Sbjct: 6    CLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGS 65

Query: 814  LVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK 873
            L++  W+++AAHC + R   P+++   LG  ++   TSP+T+   +  +++ P Y+    
Sbjct: 66   LIAPQWVLTAAHC-FPRRALPAEYRVRLGA-LRLGSTSPRTLSVPVRRVLLPPDYSEDGA 123

Query: 874  DNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTA---NILQE 930
              D+A++ L   V  +  +QP+CLP      PPG  C + GWG++   G        LQ 
Sbjct: 124  RGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSL-RPGVPLPEWRPLQG 182

Query: 931  ADVPLLSNERCQQ--------QMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNR 982
              VPLL +  C             E  +    +CAGY +G  D+CQGDSGGPL C ++  
Sbjct: 183  VRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGS 242

Query: 983  WFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016
            W L GV S+G  CALPNRPGVY  V+ ++ WIQ+
Sbjct: 243  WVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQA 276


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  177 bits (448), Expect = 6e-44
 Identities = 96/254 (37%), Positives = 142/254 (55%), Gaps = 8/254 (3%)

Query: 769  HKSCG-KKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCV 827
            H  CG    + Q ++ +I GG  A    WPW VGL + G   CG ++++  W+++AAHCV
Sbjct: 558  HDVCGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCV 617

Query: 828  YGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVN 887
              +N  P  WT I G H ++   S + V R    I+++  +N    D+DIA++ L   + 
Sbjct: 618  QLKN-NPLSWTIIAGDHDRNLKESTEQVRRA-KHIIVHEDFNTLSYDSDIALIQLSSPLE 675

Query: 888  YTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPE 947
            Y   ++P+CLP   +       C++ GWG++   G  A+ LQ+  V +L  E C+     
Sbjct: 676  YNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYS 735

Query: 948  YN---ITENMICAGYEEGG-IDSCQGDSGGPLMCQ-ENNRWFLAGVTSFGYKCALPNRPG 1002
             +   ITE MICAG+   G  D CQGDSGGPL+C+ EN  + L G+ S+G  C  P +PG
Sbjct: 736  AHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPG 795

Query: 1003 VYARVSRFTEWIQS 1016
            V+ARV  F +WIQS
Sbjct: 796  VFARVMIFLDWIQS 809



 Score =  139 bits (350), Expect = 1e-32
 Identities = 80/250 (32%), Positives = 130/250 (52%), Gaps = 23/250 (9%)

Query: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILG- 842
            +I    N+     PW V L       CG SL+  D +V+AAHC+   + +  K   +   
Sbjct: 46   RISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSG 105

Query: 843  ---LHMKSNLTSPQTVPRLIDEIVINPHYNRRR-KDNDIAMMHLEFKVNYTDYIQPICLP 898
               L  K      Q +P  + +I+ +P YN R     DIA+++L+ KV + + +QPICLP
Sbjct: 106  EYSLFQKDK--QEQNIP--VSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLP 161

Query: 899  EENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNIT---ENMI 955
            + +    PG  C  +GWG +      +N+LQE ++P++ +  C   +   N+      M+
Sbjct: 162  DSDDKVEPGILCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTML 221

Query: 956  CAGYEEGGIDSCQGDSGGPLMCQENNR-WFLAGVTSFGYKCALPNRP----------GVY 1004
            CAG+ + G+D+CQGDSGGPL+C+     W LAG+TS+   CA  + P          G++
Sbjct: 222  CAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIF 281

Query: 1005 ARVSRFTEWI 1014
            ++VS   ++I
Sbjct: 282  SKVSELMDFI 291



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 41/129 (31%), Positives = 62/129 (48%), Gaps = 8/129 (6%)

Query: 509 EPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHF 568
           E T+      E  + CG    L E  T  S+  +P+ YP+   C W + A +   I+L F
Sbjct: 404 ELTVTAVQKSEAGSGCGSLAILVEEGTNHSA-KYPDLYPSNTRCHWFICAPEKHIIKLTF 462

Query: 569 QEFDLE----NINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLAR 624
           ++F ++     I D V I  G+  +   LA   G   +  +FS++N MTV+   +D   R
Sbjct: 463 EDFAVKFSPNCIYDAVVIY-GDSEEKHKLAKLCGMLTITSIFSSSN-MTVIYFKSDGKNR 520

Query: 625 -GGFKANFT 632
             GFKA FT
Sbjct: 521 LQGFKARFT 529



 Score = 37.7 bits (86), Expect = 0.056
 Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 6/122 (4%)

Query: 227 GRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYT-----DILD 281
           G   +    G+  +  YP    ++  C W I   +   IKL+F+DF   ++     D + 
Sbjct: 420 GSLAILVEEGTNHSAKYPDLYPSNTRCHWFICAPEKHIIKLTFEDFAVKFSPNCIYDAVV 479

Query: 282 IYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNN 341
           IY G    K   A +      T    S+ +T  +     ++   GF A +T   S  LN 
Sbjct: 480 IY-GDSEEKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQGFKARFTILPSESLNK 538

Query: 342 YE 343
           +E
Sbjct: 539 FE 540



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 11/98 (11%)

Query: 544  NSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVK 603
            NS+     C W L A     IQL+   F ++    V             L VY G GP K
Sbjct: 999  NSHRTTMGCQWRLVAPLNHIIQLNIINFPMKPTTFVCHGH---------LRVYEGFGPGK 1049

Query: 604  DVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPE 641
             + ++      +++T D+L R   K NF   Y + I E
Sbjct: 1050 KLIASFAGTLAMILTKDILKRE--KLNFINTYIMHIWE 1085


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,103,374
Number of Sequences: 37866
Number of extensions: 2138148
Number of successful extensions: 7070
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 274
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 5048
Number of HSP's gapped (non-prelim): 1388
length of query: 1019
length of database: 18,247,518
effective HSP length: 112
effective length of query: 907
effective length of database: 14,006,526
effective search space: 12703919082
effective search space used: 12703919082
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.