Search of human proteins with 223646115

Search of human proteins with 223646115

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223646115 short chain dehydrogenase/reductase family 16C,
member 6 [Homo sapiens]
         (323 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223646115 short chain dehydrogenase/reductase family 16C, mem...   650   0.0  
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]          352   3e-97
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                   238   5e-63
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...   216   2e-56
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        215   4e-56
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...   186   2e-47
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...   174   7e-44
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    79   4e-15
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     78   9e-15
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    70   3e-12
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    69   6e-12
gi|40254992 carbonic reductase 4 [Homo sapiens]                        68   1e-11
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      67   2e-11
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       67   2e-11
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          65   1e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    64   1e-10
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         62   7e-10
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    62   9e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     61   2e-09
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        60   2e-09
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           59   4e-09
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    58   1e-08
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo...    54   1e-07
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ...    54   1e-07
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         53   3e-07
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    53   4e-07
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    53   4e-07
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    51   1e-06
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    50   2e-06
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    49   8e-06

>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score =  650 bits (1677), Expect = 0.0
 Identities = 323/323 (100%), Positives = 323/323 (100%)

Query: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
           MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG
Sbjct: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60

Query: 61  AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
           AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN
Sbjct: 61  AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120

Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
           NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI
Sbjct: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180

Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
           NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK
Sbjct: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240

Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT 300
           YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT
Sbjct: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT 300

Query: 301 CMASFKGRKKANELQTETEGKHQ 323
           CMASFKGRKKANELQTETEGKHQ
Sbjct: 301 CMASFKGRKKANELQTETEGKHQ 323


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score =  352 bits (903), Expect = 3e-97
 Identities = 173/302 (57%), Positives = 223/302 (73%), Gaps = 7/302 (2%)

Query: 9   VLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDV 68
           + LGK  +  LE++++ ++PK +KNVAGEIVL TGAGSGLGR LA+ FAR G++LVLWD+
Sbjct: 13  IFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDI 72

Query: 69  NQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGK 128
           N+EGN ETC++A+E G  +V  YTCDCS ++ VYRVADQV+KE GDV+IL+NNA +VTGK
Sbjct: 73  NKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGK 132

Query: 129 PFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYF 188
            FLD PD ++EKSF VN   H WT KAFLPA+I  +HGHLVCISS AG+ G+NGL+D   
Sbjct: 133 KFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD--- 189

Query: 189 VSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPIL 248
               Y ASKFAAFGFAES+F E  + K+  +K+TIVCP FI TGMFEGCT+  P LLPIL
Sbjct: 190 ----YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPIL 245

Query: 249 EQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308
           E +Y  +KI+ AIL+E++YL +PK  Y  + LK  +  K  +   +YLG+   M  F  +
Sbjct: 246 EPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQ 305

Query: 309 KK 310
           KK
Sbjct: 306 KK 307


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score =  238 bits (607), Expect = 5e-63
 Identities = 128/337 (37%), Positives = 195/337 (57%), Gaps = 35/337 (10%)

Query: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
           M+++ +  V+  K  + F+ +    ++  K+K+VAG++ L TGAGSGLGR  A+ FAR  
Sbjct: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60

Query: 61  AILVLWDVNQEGNMETCRLAKE-------------KGGK-----------KVFPYTCDCS 96
           A+LVLWD+N + N ET  + +              + G            +VF YTCD  
Sbjct: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120

Query: 97  NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAF 156
            R+ VY  A++VRKE G+V++LVNNA +V+G   L+ PD ++E++ +VN   HFWT KAF
Sbjct: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180

Query: 157 LPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKK 216
           LP +++ NHGH+V ++S  G+    G+ D       Y ASKF   GF ESL  EL   +K
Sbjct: 181 LPTMLEINHGHIVTVASSLGLFSTAGVED-------YCASKFGVVGFHESLSHELKAAEK 233

Query: 217 TEVKSTIVCPHFINTGMFEGCTSK---YPFLLPILEQEYVAKKILNAILEEQVYLMIPKF 273
             +K+T+VCP+ ++TGMF GC  +    PF LP L+ +Y  K+ + AIL +Q  +  P+ 
Sbjct: 234 DGIKTTLVCPYLVDTGMFRGCRIRKEIEPF-LPPLKPDYCVKQAMKAILTDQPMICTPRL 292

Query: 274 AYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGRKK 310
            YI   +K I+  + ++    +LG D CM  F  ++K
Sbjct: 293 MYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRK 329


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score =  216 bits (550), Expect = 2e-56
 Identities = 120/284 (42%), Positives = 176/284 (61%), Gaps = 11/284 (3%)

Query: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
           M++I +  +LL    Y +LESLV   IP+++K+VAGEIVL TGAG G+GRQ    FA+  
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
           +ILVLWD+N+ G  ET    + K G     Y  DCSNR+E+YR  +QV+KE GDVTI+VN
Sbjct: 61  SILVLWDINKRGVEETAAECR-KLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVN 119

Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
           NA  V     L   D  + K+F VN + HFW  KA LP++++ NHGH+V ++S+ G  GI
Sbjct: 120 NAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGI 179

Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
                  ++ PY S SKFAA GF   L  EL  + KT +K++ +CP F+NTG  +  +++
Sbjct: 180 P------YLIPYCS-SKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR 232

Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQII 284
              L P+LE + V + +++ IL  +  + +P +  I L L++ +
Sbjct: 233 ---LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFL 273


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score =  215 bits (548), Expect = 4e-56
 Identities = 127/299 (42%), Positives = 176/299 (58%), Gaps = 13/299 (4%)

Query: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
           M  + D  +LL       LES V   IPK++K+V GEIVL TGAG G+GR  A  FA+  
Sbjct: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60

Query: 61  AILVLWDVNQEGNMETCRLAKEKG-GKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILV 119
           + LVLWD+N+ G  ET   AK KG G KV  +  DCSNR+++Y  A +V+ E GDV+ILV
Sbjct: 61  SKLVLWDINKHGLEETA--AKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILV 118

Query: 120 NNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVG 179
           NNA +V         D  +EK+F VN + HFWT KAFLPA+ K NHGH+V ++S AG V 
Sbjct: 119 NNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVS 178

Query: 180 INGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTS 239
           +  L         Y +SKFAA GF ++L  EL  ++ T VK+T +CP+F+NTG  +  ++
Sbjct: 179 VPFLL-------AYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST 231

Query: 240 KYPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGV 298
               L P LE E V  ++++ IL EQ  + IP        L++I+  + L    + + V
Sbjct: 232 S---LGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISV 287


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score =  186 bits (473), Expect = 2e-47
 Identities = 111/294 (37%), Positives = 169/294 (57%), Gaps = 11/294 (3%)

Query: 16  YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAI-LVLWDVNQEGNM 74
           Y  +++ V  ++P K ++++ E VL TG G G+GRQLA  FA  GA  +VLW   ++   
Sbjct: 18  YLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLK 77

Query: 75  ETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIP 134
           ET    ++ G +  + + CD  NR+EVY+ A  VR++ GD+TILVNNA +V GK  +D  
Sbjct: 78  ETTEEIRQMGTECHY-FICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSD 136

Query: 135 DHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYS 194
           D  + KS  +N +  FWT KAFLP +++  +GH+VC++S+  +  I G  D       Y 
Sbjct: 137 DDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAID-------YC 189

Query: 195 ASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVA 254
            SK +AF F ESL   L ++    V +T V P   +T MF+G   ++P L P L+ E VA
Sbjct: 190 TSKASAFAFMESL--TLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVA 247

Query: 255 KKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308
           ++ + A+   Q  L++P   +  +ILK I+    L    ++ G  TCM +FKGR
Sbjct: 248 RRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGR 301


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score =  174 bits (442), Expect = 7e-44
 Identities = 105/284 (36%), Positives = 157/284 (55%), Gaps = 47/284 (16%)

Query: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
           M++I +  +LL    Y +LESLV   IP+++K+VAGEIVL TGAG G+GRQ    FA+  
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
           +ILVLWD+N                                     +V+KE GDVTI+VN
Sbjct: 61  SILVLWDIN-------------------------------------KVKKEVGDVTIVVN 83

Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
           NA  V     L   D  + K+F VN + HFW  KA LP++++ NHGH+V ++S+ G  GI
Sbjct: 84  NAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGI 143

Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
                  ++ PY S SKFAA GF   L  EL  + KT +K++ +CP F+NTG  +  +++
Sbjct: 144 P------YLIPYCS-SKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR 196

Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQII 284
              L P+LE + V + +++ IL  +  + +P +  I L L++ +
Sbjct: 197 ---LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFL 237


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 76/244 (31%), Positives = 112/244 (45%), Gaps = 26/244 (10%)

Query: 1   MDVIADTSVL------LGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAI 54
           MD I  T++L      LG F  + L   V     + K  +   +V+ TGA SGLG++ A 
Sbjct: 16  MDFITSTAILPLLFGCLGVFGLFRLLQWV-----RGKAYLRNAVVVITGATSGLGKECAK 70

Query: 55  YFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVF---PY--TCDCSNRQEVYRVADQVR 109
            F   GA LVL   N     E  R        KV    PY  T D ++   +   A ++ 
Sbjct: 71  VFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEIL 130

Query: 110 KEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLV 169
           + FG V ILVNNA +      +D    + ++    N        KA LP++IK   GH+V
Sbjct: 131 QCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIV 190

Query: 170 CISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFI 229
            ISSI G + I   S        Y+ASK A   F + L  E+   ++ E++ T++ P +I
Sbjct: 191 AISSIQGKMSIPFRS-------AYAASKHATQAFFDCLRAEM---EQYEIEVTVISPGYI 240

Query: 230 NTGM 233
           +T +
Sbjct: 241 HTNL 244


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 26/232 (11%)

Query: 36  GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQE------GNMETCRLAKE---KGGK 86
           G +VL TGAG+GLGR  A+ FA  GA++V+ D+  +      G++   ++ +E   +GGK
Sbjct: 9   GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68

Query: 87  KVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
            V  Y     + +E  +V       FG + ++VNNA ++  + F  I D   +    V+ 
Sbjct: 69  AVANY----DSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHL 124

Query: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
              F   +A    + K  +G ++  SS +G+ G  G ++       YSA+K    G A S
Sbjct: 125 RGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQAN-------YSAAKLGLLGLANS 177

Query: 207 LFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVAKKIL 258
           L  E    +K+ +    + P   N G     T     L+  L+ EYVA  +L
Sbjct: 178 LAIE---GRKSNIHCNTIAP---NAGSRMTQTVMPEDLVEALKPEYVAPLVL 223


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 56/205 (27%), Positives = 96/205 (46%), Gaps = 16/205 (7%)

Query: 33  NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
           +V G++ L TGA  G+GR  A      GA + L D N E  ++ C+ A ++    +K   
Sbjct: 2   HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60

Query: 91  YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
             CD +++Q++     +V   FG + ILVNNA +   K +        EK+  +N ++  
Sbjct: 61  IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112

Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
                 L  + K N G    I +++ + G+  ++ +    P Y ASK    GF  S    
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRSAALA 168

Query: 211 LTMIKKTEVKSTIVCPHFINTGMFE 235
             ++  + V+   +CP F+NT + E
Sbjct: 169 ANLM-NSGVRLNAICPGFVNTAILE 192


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 33/293 (11%)

Query: 16  YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNME 75
           +  L  +V  +I  K   + G  V+ TG  SG+G+ +AI   + GA + L   N++  ++
Sbjct: 12  FVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQ 71

Query: 76  T---CRLAKEKGGKKVFPYTCDCS-NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFL 131
                 +      + V   + D S +  +V  V  Q +++ G V +LVN A +     F 
Sbjct: 72  AKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFE 131

Query: 132 DIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSP 191
           D+     E+   +N +   +  +A +  + +   G +V +SS AG +G+ G +       
Sbjct: 132 DLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFT------- 184

Query: 192 YYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQE 251
            YSASKFA  G AE+L  E   +K   V  T+  P   +T              P   +E
Sbjct: 185 AYSASKFAIRGLAEALQME---VKPYNVYITVAYPPDTDT--------------PGFAEE 227

Query: 252 YVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMAS 304
              K +   ++ E   +  P+      + KQI+   +   F   LG D  M S
Sbjct: 228 NRTKPLETRLISETTSVCKPE-----QVAKQIVKDAIQGNFNSSLGSDGYMLS 275


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 14/191 (7%)

Query: 43  GAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVY 102
           G   G+GR +A   AR G  L +   N EG       A + GG  +  ++CD +   +V 
Sbjct: 9   GGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAA---AGDLGGDHL-AFSCDVAKEHDVQ 64

Query: 103 RVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIK 162
              +++ K  G V  LVN A +      +      +      N +    TCKA +  +I+
Sbjct: 65  NTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQ 124

Query: 163 ANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKST 222
              G +V + SI G+ G +G S        YSASK    GF+ +L  E   + + +++  
Sbjct: 125 QQGGSIVNVGSIVGLKGNSGQS-------VYSASKGGLVGFSRALAKE---VARKKIRVN 174

Query: 223 IVCPHFINTGM 233
           +V P F++T M
Sbjct: 175 VVAPGFVHTDM 185


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 13/259 (5%)

Query: 10  LLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVN 69
           +LG F  Y+  S   +  P+    + G+ V+ TGA  G+GR++A + A+ GA +V+   +
Sbjct: 11  ILGLFMAYYYYSANEEFRPEM---LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS 67

Query: 70  QEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKP 129
           +E   +      E G            +     +   Q  K  G + +L+ N    T   
Sbjct: 68  KETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLN 127

Query: 130 FLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFV 189
                 H V KS  VN +++     A LP ++K ++G +V +SS+AG V        Y +
Sbjct: 128 LFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVA-------YPM 179

Query: 190 SPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILE 249
              YSASKFA  GF  S+  E + + +  V  T+     I+T       S    +    +
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYS-VSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPK 238

Query: 250 QEYVAKKIL-NAILEEQVY 267
           +E   + I   A+ +E+VY
Sbjct: 239 EECALEIIKGGALRQEEVY 257


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 13/259 (5%)

Query: 10  LLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVN 69
           +LG F  Y+  S   +  P+    + G+ V+ TGA  G+GR++A + A+ GA +V+   +
Sbjct: 11  ILGLFMAYYYYSANEEFRPEM---LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS 67

Query: 70  QEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKP 129
           +E   +      E G            +     +   Q  K  G + +L+ N    T   
Sbjct: 68  KETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLN 127

Query: 130 FLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFV 189
                 H V KS  VN +++     A LP ++K ++G +V +SS+AG V        Y +
Sbjct: 128 LFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVA-------YPM 179

Query: 190 SPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILE 249
              YSASKFA  GF  S+  E + + +  V  T+     I+T       S    +    +
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYS-VSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPK 238

Query: 250 QEYVAKKIL-NAILEEQVY 267
           +E   + I   A+ +E+VY
Sbjct: 239 EECALEIIKGGALRQEEVY 257


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 52/182 (28%), Positives = 85/182 (46%), Gaps = 17/182 (9%)

Query: 35  AGEIVLTTGAGSGLGRQLAIYFA-----RFGAILVLWDVNQEGNMETCRLAKEKGGKKVF 89
           A   VL +G  SG+G +LA+  A     R+  +  + D+ ++  +E    A E  G+ + 
Sbjct: 4   APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAA--AGEALGQTLT 61

Query: 90  PYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITH 149
               D  + + V +    ++   G+V +LVNNA +    P   +    ++  F  N    
Sbjct: 62  VAQLDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGA 118

Query: 150 FWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
               KA LP + +   GH+V ISS+ G+ G+         +  Y+ASKFA  GF ESL  
Sbjct: 119 VRLVKAVLPGMKRRRQGHIVVISSVMGLQGV-------IFNDVYAASKFALEGFFESLAI 171

Query: 210 EL 211
           +L
Sbjct: 172 QL 173


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 64/205 (31%), Positives = 92/205 (44%), Gaps = 14/205 (6%)

Query: 31  KKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEG--NMETCRLAKEKGGKKV 88
           K  V  ++V+ T A SGLG++ A  F   GA LVL   N E   N+    ++     K  
Sbjct: 32  KSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTF 91

Query: 89  FP--YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
            P     D S+   V  VA +V   +G V IL+NNA +    P   I   + +K    N 
Sbjct: 92  TPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANY 151

Query: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
                  KA LP +I    G +V +++I G  GI            Y+ASK AA GF + 
Sbjct: 152 FGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIP-------FRTTYAASKHAALGFFDC 204

Query: 207 LFFELTMIKKTEVKSTIVCPHFINT 231
           L  E   +++ +V  + V P FI +
Sbjct: 205 LRAE---VEEYDVVISTVSPTFIRS 226


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 6/145 (4%)

Query: 34  VAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQE------GNMETCRLAKEKGGKK 87
           +AG  V  TGA  G+G+ +A+  A+ GA +V+     +      G + T     E  G K
Sbjct: 8   LAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGK 67

Query: 88  VFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAI 147
             P   D  + Q++    ++  K+FG + ILVNNA  ++    LD P   ++    VN  
Sbjct: 68  ALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTR 127

Query: 148 THFWTCKAFLPAVIKANHGHLVCIS 172
             +   KA +P + K+   H++ IS
Sbjct: 128 GTYLASKACIPYLKKSKVAHILNIS 152


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 12/201 (5%)

Query: 38  IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGG---KKVFPYTCD 94
           +V  TGA SG+G +LA   ++ G  LVL            R   E G    K +     D
Sbjct: 52  VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111

Query: 95  CSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCK 154
            ++          V +EFG + ILVNN  +      +D    +  K   +N +      K
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171

Query: 155 AFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMI 214
             LP +I+   G +V ++SI G++ +        +S  Y ASK A  GF   L  EL   
Sbjct: 172 CVLPHMIERKQGKIVTVNSILGIISVP-------LSIGYCASKHALRGFFNGLRTELATY 224

Query: 215 KKTEVKSTIVCPHFINTGMFE 235
               V +  +CP  + + + E
Sbjct: 225 PGIIVSN--ICPGPVQSNIVE 243


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 48/196 (24%), Positives = 95/196 (48%), Gaps = 19/196 (9%)

Query: 36  GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
           G++++ T A  G+G+  A+ FAR GA ++  D+N+    E   L K  G   +     D 
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE---LEKYPG---IQTRVLDV 59

Query: 96  SNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKA 155
           + ++++ + A++V +    + +L N A  V     LD  +   + S  +N  + +   KA
Sbjct: 60  TKKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKA 115

Query: 156 FLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIK 215
           FLP ++    G+++ +SS+A    + G+ +       YS +K A  G  +S+  +     
Sbjct: 116 FLPKMLAQKSGNIINMSSVAS--SVKGVVNRC----VYSTTKAAVIGLTKSVAADFI--- 166

Query: 216 KTEVKSTIVCPHFINT 231
           +  ++   VCP  ++T
Sbjct: 167 QQGIRCNCVCPGTVDT 182


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 53/202 (26%), Positives = 93/202 (46%), Gaps = 19/202 (9%)

Query: 38  IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMET----CRLAKEKGGKKVFPYTC 93
           + L TGA  G+G  +A    + G + V+      GN+E     C+ A   G   + PY C
Sbjct: 13  LALVTGASGGIGAAVARALVQQG-LKVVGCARTVGNIEELAAECKSAGYPG--TLIPYRC 69

Query: 94  DCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTC 153
           D SN +++  +   +R +   V I +NNA L      L       +  F VN +      
Sbjct: 70  DLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICT 129

Query: 154 KAFLPAVIKAN--HGHLVCISSIAG--VVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
           +    ++ + N   GH++ I+S++G  V+ ++       V+ +YSA+K+A     E L  
Sbjct: 130 REAYQSMKERNVDDGHIININSMSGHRVLPLS-------VTHFYSATKYAVTALTEGLRQ 182

Query: 210 ELTMIKKTEVKSTIVCPHFINT 231
           EL    +T +++T + P  + T
Sbjct: 183 ELRE-AQTHIRATCISPGVVET 203


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 57/211 (27%), Positives = 95/211 (45%), Gaps = 18/211 (8%)

Query: 38  IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFP------Y 91
           + L TGAGSG+GR +++  A  GA +   D+++    ET RL    G K+  P      +
Sbjct: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72

Query: 92  TCDCSNRQEVYRVADQVRKEFG-DVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
             D S  +    + +QV+  F    +++V+ A +   +  L + +   +K   VN    F
Sbjct: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132

Query: 151 WTCKAFLPAVIKAN-HGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
              +A   A++     G ++ ISSI G VG  G ++       Y+ASK    G  ++   
Sbjct: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN-------YAASKAGVIGLTQTAAR 185

Query: 210 ELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
           EL    +  ++   V P FI T M +    K
Sbjct: 186 EL---GRHGIRCNSVLPGFIATPMTQKVPQK 213


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 49/176 (27%), Positives = 82/176 (46%), Gaps = 15/176 (8%)

Query: 33  NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
           +V G++ L TGA  G+GR  A      GA + L D N E  ++ C+ A ++    +K   
Sbjct: 2   HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60

Query: 91  YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
             CD +++Q++     +V   FG + ILVNNA +   K +        EK+  +N ++  
Sbjct: 61  IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112

Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
                 L  + K N G    I +++ + G+  ++ +    P Y ASK    GF  S
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRS 164


>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 21/224 (9%)

Query: 36  GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
           G++ + TGA  G+GR +A+   + GA + +   + +      + A+  GG+ V P  CD 
Sbjct: 7   GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65

Query: 96  SNRQEVYRVADQV-RKEFGDVTILVNNADL-------VTGKPFLDIPDHMVEKSFLVNAI 147
           S   EV  + +QV R++ G + +LVNNA            K F + P  M +    V   
Sbjct: 66  SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125

Query: 148 THFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
            H++        ++ A  G +V ISS   +        +Y  +  Y   K A    A   
Sbjct: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL--------QYMFNVPYGVGKAACDKLAADC 177

Query: 208 FFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLL-PILEQ 250
             EL   ++  V    + P  + T + +   +K   L  P+L+Q
Sbjct: 178 AHEL---RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ 218


>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 21/224 (9%)

Query: 36  GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
           G++ + TGA  G+GR +A+   + GA + +   + +      + A+  GG+ V P  CD 
Sbjct: 7   GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65

Query: 96  SNRQEVYRVADQV-RKEFGDVTILVNNADL-------VTGKPFLDIPDHMVEKSFLVNAI 147
           S   EV  + +QV R++ G + +LVNNA            K F + P  M +    V   
Sbjct: 66  SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125

Query: 148 THFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
            H++        ++ A  G +V ISS   +        +Y  +  Y   K A    A   
Sbjct: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL--------QYMFNVPYGVGKAACDKLAADC 177

Query: 208 FFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLL-PILEQ 250
             EL   ++  V    + P  + T + +   +K   L  P+L+Q
Sbjct: 178 AHEL---RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ 218


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 17/188 (9%)

Query: 31  KKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCR-LAKEKGGKKVF 89
           K  + G+ V+ TGA +G+G+Q A+  AR G  ++L       +ME C   AK+  G+ + 
Sbjct: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIIL----ACRDMEKCEAAAKDIRGETLN 88

Query: 90  PYT----CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVN 145
            +      D ++ + +   A ++ +E   V IL+NNA  V   P     D   E  F VN
Sbjct: 89  HHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAG-VMRCPHWTTEDGF-EMQFGVN 146

Query: 146 AITHFWTCKAFLPAVIKANHGHLVCISSIAGVVG------INGLSDEYFVSPYYSASKFA 199
            + HF      L  +  +    ++ +SS+A V G      +N  + +Y     Y  SK A
Sbjct: 147 HLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLA 206

Query: 200 AFGFAESL 207
              F + L
Sbjct: 207 IVLFTKEL 214


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 54/181 (29%), Positives = 84/181 (46%), Gaps = 12/181 (6%)

Query: 33  NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYT 92
           ++ G  VL TGA +G+G +LA ++AR G+ LVL    +    +     ++ G  KVF   
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 93  CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL--VNAITHF 150
            D ++ +    V      + G +  LV N   + G P            +L  VN +++ 
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNH--IGGAPAGTRARSPQATRWLMQVNFVSYV 143

Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
                 LP++  +  G LV +SS+ G V  +      F +P YSA+KFA  GF  SL  E
Sbjct: 144 QLTSRALPSLTDSK-GSLVVVSSLLGRVPTS------FSTP-YSAAKFALDGFFGSLRRE 195

Query: 211 L 211
           L
Sbjct: 196 L 196


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 54/181 (29%), Positives = 84/181 (46%), Gaps = 12/181 (6%)

Query: 33  NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYT 92
           ++ G  VL TGA +G+G +LA ++AR G+ LVL    +    +     ++ G  KVF   
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 93  CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL--VNAITHF 150
            D ++ +    V      + G +  LV N   + G P            +L  VN +++ 
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNH--IGGAPAGTRARSPQATRWLMQVNFVSYV 143

Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
                 LP++  +  G LV +SS+ G V  +      F +P YSA+KFA  GF  SL  E
Sbjct: 144 QLTSRALPSLTDSK-GSLVVVSSLLGRVPTS------FSTP-YSAAKFALDGFFGSLRRE 195

Query: 211 L 211
           L
Sbjct: 196 L 196


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 48/179 (26%), Positives = 75/179 (41%), Gaps = 14/179 (7%)

Query: 34  VAGEIVLTTGAGSGLGRQLAIYFAR-----FGAILVLWDVNQEGNMETCRLAKEKGGKKV 88
           +A  +VL TG  SG+G  LA+  A      F     L D+  +G +     A       +
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60

Query: 89  FPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAIT 148
                D  + + V    ++V +  G V +LV NA L    P   + +  V     VN + 
Sbjct: 61  ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118

Query: 149 HFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
                +AFLP + +   G ++   S+ G++G+         +  Y ASKFA  G  ESL
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP-------FNDVYCASKFALEGLCESL 170


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 13/149 (8%)

Query: 35  AGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCD 94
           AG++V+ TG G G+G  +   F   GA +V+ D ++ G     R  +++    VF   CD
Sbjct: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPGAVF-ILCD 62

Query: 95  CSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL----VNAITHF 150
            +   +V  +  +  + FG +  +VNNA      P    P+    + F     +N +  +
Sbjct: 63  VTQEDDVKTLVSETIRRFGRLDCVVNNAG---HHPPPQRPEETSAQGFRQLLELNLLGTY 119

Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVG 179
              K  LP  ++ + G+++ ISS+ G +G
Sbjct: 120 TLTKLALP-YLRKSQGNVINISSLVGAIG 147


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 52/202 (25%), Positives = 100/202 (49%), Gaps = 20/202 (9%)

Query: 36  GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
           GE  + TG+  G+G+  A   A+ G  +VL   +++   +     KEK   +      D 
Sbjct: 50  GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109

Query: 96  SNRQEVYRVADQVRKEFG--DVTILVNNADLVTGKP--FLDIP--DHMVEKSFLVNAITH 149
           ++ +++Y   D+++      ++ ILVNN  +    P  FLD+P  D++++K   +N ++ 
Sbjct: 110 AS-EDIY---DKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165

Query: 150 FWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
               +  LP +++ + G ++ ISS +G++ +  L+        YSA+K     F++ L  
Sbjct: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLT-------IYSATKTFVDFFSQCLHE 218

Query: 210 ELTMIKKTEVKSTIVCPHFINT 231
           E    K   V+S  V P+F+ T
Sbjct: 219 EYRS-KGVFVQS--VLPYFVAT 237


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,007,736
Number of Sequences: 37866
Number of extensions: 445796
Number of successful extensions: 954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 870
Number of HSP's gapped (non-prelim): 69
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.