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Search of human proteins with 222537747
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
(673 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222537747 hypothetical protein LOC342979 [Homo sapiens] 1342 0.0
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 119 9e-27
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 108 2e-23
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 77 5e-14
gi|8923243 palmdelphin [Homo sapiens] 74 4e-13
gi|82617626 paralemmin 2 isoform b [Homo sapiens] 71 3e-12
gi|82524851 paralemmin 2 isoform a [Homo sapiens] 71 3e-12
gi|22325356 PALM2-AKAP2 protein isoform 2 [Homo sapiens] 71 3e-12
gi|6005709 PALM2-AKAP2 protein isoform 1 [Homo sapiens] 71 3e-12
gi|93141029 paralemmin isoform 2 [Homo sapiens] 70 5e-12
gi|93141031 paralemmin isoform 1 [Homo sapiens] 70 5e-12
gi|119220598 apolipoprotein B48 receptor [Homo sapiens] 69 1e-11
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 68 3e-11
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 67 5e-11
gi|157738619 smoothelin-like 1 [Homo sapiens] 65 2e-10
gi|55741677 SET domain containing 1A [Homo sapiens] 64 6e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 64 6e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 64 6e-10
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 64 6e-10
gi|33286446 opioid growth factor receptor [Homo sapiens] 63 1e-09
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 62 2e-09
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 61 4e-09
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 58 2e-08
gi|38176300 nestin [Homo sapiens] 58 3e-08
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 58 3e-08
gi|210032580 SET domain containing 1B [Homo sapiens] 57 4e-08
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 57 6e-08
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 57 7e-08
gi|17975763 myelin transcription factor 1 [Homo sapiens] 57 7e-08
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 55 2e-07
>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
Length = 673
Score = 1342 bits (3474), Expect = 0.0
Identities = 673/673 (100%), Positives = 673/673 (100%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE
Sbjct: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGH 120
PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGH
Sbjct: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGH 120
Query: 121 RPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDS 180
RPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDS
Sbjct: 121 RPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDS 180
Query: 181 SEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPEL 240
SEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPEL
Sbjct: 181 SEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPEL 240
Query: 241 EAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQ 300
EAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQ
Sbjct: 241 EAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQ 300
Query: 301 TSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEG 360
TSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEG
Sbjct: 301 TSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEG 360
Query: 361 LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMS 420
LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMS
Sbjct: 361 LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMS 420
Query: 421 PVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEE 480
PVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEE
Sbjct: 421 PVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEE 480
Query: 481 EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNL 540
EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNL
Sbjct: 481 EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNL 540
Query: 541 EQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQG 600
EQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQG
Sbjct: 541 EQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQG 600
Query: 601 PLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEAS 660
PLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEAS
Sbjct: 601 PLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEAS 660
Query: 661 GPKQKTCQCCAVM 673
GPKQKTCQCCAVM
Sbjct: 661 GPKQKTCQCCAVM 673
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 119 bits (298), Expect = 9e-27
Identities = 158/583 (27%), Positives = 226/583 (38%), Gaps = 62/583 (10%)
Query: 125 QSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEAN 184
Q I++ TD + A + G T P S + G PG Q PG
Sbjct: 1690 QQILQRKRGEHTD-GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEG 1748
Query: 185 GPCPSPIPTPEQGLSQRAVPSEGRVGE------AKGGGVVSVVWEGLRATEDCATGATGP 238
+ P+ G ++ ++ R G+ + G + EG +E TG G
Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
Query: 239 ELEAKVEEVVL----EAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGR 294
E ++ + G GA +E P E G + EGV +AE G
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAP----EAEGEAQPESEGVEAPEAE-----GD 1859
Query: 295 VPEVVQTSSPRLQE----RLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLS 350
E + P ++ E A E EDV E + Q S G E E +
Sbjct: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
Query: 351 EEWEELLVEGLEGPEVAGRE--RGDESPLGAEGAKTGGGE--ETWEAEKRKAEES----- 401
E E L EG + PE G E +E+ AEG E E+ EAE+ ES
Sbjct: 1920 ESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979
Query: 402 --MGIGSEEKPGTGRDEAEMSPVVERKG----GEKKLELESRGSAEKLGTEREGGEEPLG 455
+ + ++E G + E+E E +G E++ + ES G + +E E +E G
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG 2039
Query: 456 IERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETL 515
+K EG + E +G E AEEE E V++ GE PE+ E ++A+ GE
Sbjct: 2040 ETQKTEGDAQPESDGVEAPE-AEEEAQEAEGEVQEAEGEAHPES--EDVDAQEAEGEAQP 2096
Query: 516 EAEK-RGGEESLETEKTQG-----TEGDLNLEQGSREGSESQAEEM--NEAGPPLEANTE 567
E+E E E +K +G TEG+ E E E++ E +E +A E
Sbjct: 2097 ESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGE 2156
Query: 568 TRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQG 627
+PE EG + QE EEE E G+A P APE E QP L+G
Sbjct: 2157 AQPESEGIEAQEA-----EEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEG 2211
Query: 628 -EGPSANPSAHPVPTYAPA------RQPEPSAPTEGEEASGPK 663
E P A A P P QPE T+GE+ P+
Sbjct: 2212 VEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
Score = 97.8 bits (242), Expect = 3e-20
Identities = 156/600 (26%), Positives = 220/600 (36%), Gaps = 74/600 (12%)
Query: 68 KDPQSPEGQAQARIRNLEDSLFTLQSQL--QLLQSASTGAQHKPSGRPSWRRQGHRPLSQ 125
KDP+ E + A + E ++ +L ++ G G + GH Q
Sbjct: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
Query: 126 SIVEAGS---VGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSE 182
AG GQ+D + P PES + P A GD+ E
Sbjct: 1816 GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV-------------EAPEAEGDAQE 1862
Query: 183 ANG---PCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPE 239
A G P + PE A P V + V EG A E A PE
Sbjct: 1863 AEGEAQPESEDVEAPEA--EGEAQPESEDVETPEAEWEVQPESEGAEAPE--AEKEAQPE 1918
Query: 240 LEA-KVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEV 298
E+ + E E + +GA + E +E G + E + +AE + PE
Sbjct: 1919 TESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ----PES 1974
Query: 299 VQTSSPRLQ---ERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEE 355
+ ++ + E A E EDV EG+ Q + VE SE E
Sbjct: 1975 EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEA 2034
Query: 356 LLVEG----LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPG 411
VEG EG + G E+P E A+ GE EAE ES + ++E G
Sbjct: 2035 QEVEGETQKTEG-DAQPESDGVEAPEAEEEAQEAEGE-VQEAEGEAHPESEDVDAQEAEG 2092
Query: 412 TGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIER-KVEGHLRAEKEG 470
+ E+E E +G +K E E TE E E GIE + EG + E EG
Sbjct: 2093 EAQPESEGVEAPEAEGEAQKAE-----GIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147
Query: 471 DEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGE-----ETLEAEKRGGEES 525
E + AE E E G+E + EEE + E +EA GE E +EA + GE
Sbjct: 2148 -VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206
Query: 526 LETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGAL 585
E E + E +E +A+ E EA E +PE EG EK
Sbjct: 2207 PELEGVEAPE------------AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK---- 2250
Query: 586 EEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPA 645
PQ + G G +A+ + +P PE P G+ P P + P+ + A
Sbjct: 2251 ----GSPQVSL-GDGQSEEASE--SSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRA 2303
Score = 82.0 bits (201), Expect = 2e-15
Identities = 115/432 (26%), Positives = 160/432 (37%), Gaps = 78/432 (18%)
Query: 290 GEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGE------------ 337
GE V + P ++ A G + QG +G+ G G +
Sbjct: 1703 GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGE 1762
Query: 338 -EGSFIWVER--------VTLSEEWEELLVEG---LEGPEVAGRERGDESPLGAEGAKTG 385
EG + ER + E E EG E E G+ G E L E A
Sbjct: 1763 AEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAA--A 1820
Query: 386 GGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGT 445
GG++ + +++ + GI + E G + E+E E +G ++ E E++ +E +
Sbjct: 1821 GGDQ----DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV-- 1874
Query: 446 EREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLE 505
E P + EG + E E D E AE E E G E E+E + E +E
Sbjct: 1875 -----EAP-----EAEGEAQPESE-DVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE 1923
Query: 506 AERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGP--PLE 563
A GE+ E E G E E Q EG E E E++ E E+ LE
Sbjct: 1924 ALETEGED--EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALE 1981
Query: 564 ANTETRPEKEGPQPQEKPVGALEEE---------------GVKPQTAAEG---------- 598
ET+ + QP+ + V A E E GV+ Q +EG
Sbjct: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041
Query: 599 QGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGE- 657
Q GDA P APE E Q +GE A AHP A++ E A E E
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Query: 658 ----EASGPKQK 665
EA G QK
Sbjct: 2101 VEAPEAEGEAQK 2112
Score = 62.8 bits (151), Expect = 1e-09
Identities = 129/576 (22%), Positives = 216/576 (37%), Gaps = 110/576 (19%)
Query: 53 DGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGR 112
+G A E P S+D ++PE + +A+ + + + T +++ ++ Q S GA+ + +
Sbjct: 1857 EGDAQEAEGEAQPESEDVEAPEAEGEAQPES--EDVETPEAEWEV-QPESEGAEAPEAEK 1913
Query: 113 PSWRRQGHRPLSQSIVEAGSVGQTDLNKRAS--LPAGLVGTPPESPSEPREDVLGFLPGP 170
+ +P ++S+ + G+ + + A E ++P +V+
Sbjct: 1914 EA------QPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE----S 1963
Query: 171 RQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATED 230
++ A SE + T E + + EA+G E A E+
Sbjct: 1964 QEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG--------EMQEAEEE 2015
Query: 231 CATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMG 290
+ G E + K E G + E+ ++ G + +GV +AE
Sbjct: 2016 AQPESDGVEAQPKSE-----------GEEAQEVEGETQKTEGDAQPESDGVEAPEAE--- 2061
Query: 291 EIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGG-----EEGSFIWVE 345
E Q + +QE E A E EDV EG+ Q S G EG E
Sbjct: 2062 ------EEAQEAEGEVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 346 RVTLSEEWEELLVE--GLEGPEVAGRERGDESPLGAEGAK-----TGGGEETWEAEKRKA 398
+ E E E G+E PE G + + + A+ A+ G E EAE+
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
Query: 399 EESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIER 458
E G+ + E G + E+E E +G E + ELE + E E E EP G+E
Sbjct: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEG-EAQPELEGVEAPE---AEEEAQPEPEGVET 2230
Query: 459 -KVEGHLRAEKEGDE--EKRGA--------EEEEVEE---------PLGVEKKGGE---E 495
+ EG + E EG+ EK+G+ + EE E P GG+ +
Sbjct: 2231 PEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
Query: 496 EPEATKEPLEAE--------RKGGEE----------------TLEAEKRGGE---ESLET 528
P + P + +K E T AE++ ES +
Sbjct: 2291 RPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350
Query: 529 EKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEA 564
E+ + G EQG+ EG + Q ++ + P EA
Sbjct: 2351 EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEA 2386
Score = 58.9 bits (141), Expect = 1e-08
Identities = 60/208 (28%), Positives = 96/208 (46%), Gaps = 25/208 (12%)
Query: 466 AEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATK-EPLEAERKGGEETLEAEKRGGEE 524
AE++ +E++ + E++ E E+ EE E T+ E L+ E EET + E+ EE
Sbjct: 1276 AERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEET-KTEEGLQEE 1334
Query: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPP--LEANTETRPEKEGPQ---PQE 579
++ E+T+ TEG+ E+ E+Q EE+ E G E + KEGP+ E
Sbjct: 1335 GVQLEETKETEGEGQQEE------EAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
Query: 580 KPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPV 639
L+EEG+ + + GQ L +A+ +P + E P+ + E A+ SA P
Sbjct: 1389 ALEEGLKEEGLPEEGSVHGQ-ELSEAS-----SPDGKGSQEDDPVQEEEAGRASASAEPC 1442
Query: 640 PTYAPARQPEPSA------PTEGEEASG 661
P EP + P+ E SG
Sbjct: 1443 PAEGTEEPTEPPSHLSETDPSASERQSG 1470
Score = 44.3 bits (103), Expect = 4e-04
Identities = 59/209 (28%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 345 ERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGI 404
E V L E E EGL+ V E E L EG + +ET E E ++ EE+
Sbjct: 1299 EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKET-EGEGQQEEEAQLE 1357
Query: 405 GSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHL 464
EE G G E + ++G E L+ G A + G + EG E E V G
Sbjct: 1358 EIEETGGEGLQEEGVQLEEVKEGPEGGLQ----GEALEEGLKEEGLPE----EGSVHGQE 1409
Query: 465 RAEKEGDEEKRGAEEEEV-EEPLGVEKKGGEEEP-EATKEPLE------------AERKG 510
+E + K E++ V EE G E P E T+EP E +ER+
Sbjct: 1410 LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQS 1469
Query: 511 GEETLEAEKRG------GEESLETEKTQG 533
G + ++ G+E + + TQG
Sbjct: 1470 GSQLEPGLEKPPGATMMGQEHTQAQPTQG 1498
Score = 33.5 bits (75), Expect = 0.66
Identities = 66/321 (20%), Positives = 103/321 (32%), Gaps = 28/321 (8%)
Query: 365 EVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEA---EMSP 421
+V E+G P + G + EA++ + E+ + P R S
Sbjct: 809 QVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSS 868
Query: 422 VVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEE 481
G + G + + GT R+ G P + +G + +EE+
Sbjct: 869 SCGSTGSSHQSTARGPGGSPQEGT-RQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKT 927
Query: 482 VEE---PLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDL 538
+ P G E+ G + EA + + + E L E T G L
Sbjct: 928 LRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGL 987
Query: 539 N---LEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTA 595
++ G E E LE + PE EG G EGV A
Sbjct: 988 RGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAA 1047
Query: 596 AEGQGPLGDATPLLAETPAP-----EQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEP 650
EG ++E PA E PA C+ L+ + S + ++Q P
Sbjct: 1048 PEG----------VSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRP 1097
Query: 651 SAPTEGEEASGPKQKTCQCCA 671
S+ E S P + C A
Sbjct: 1098 SSV---PEVSRPMARRLSCSA 1115
Score = 33.1 bits (74), Expect = 0.86
Identities = 27/125 (21%), Positives = 39/125 (31%), Gaps = 6/125 (4%)
Query: 476 GAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTE 535
G + +G E+K G E ++ GG E +GG + +G
Sbjct: 479 GVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPE------QGGRLTPRARSEEGAS 532
Query: 536 GDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTA 595
D + GS EGS A T + EG P + Q
Sbjct: 533 SDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAE 592
Query: 596 AEGQG 600
+GQG
Sbjct: 593 TQGQG 597
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 108 bits (269), Expect = 2e-23
Identities = 134/415 (32%), Positives = 173/415 (41%), Gaps = 51/415 (12%)
Query: 198 LSQRAVPSEGR---VGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGD 254
L+ +A SEG+ VGEA+ G EG R C G++G E E E
Sbjct: 630 LTDKAEVSEGKAKSVGEAEDGP------EG-RGDGTCEEGSSGAEHWQDEER---EKGEK 679
Query: 255 RKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAA 314
KG G +E P +++ E + G + E G E Q +E
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE 739
Query: 315 SIEGEDVPQGSPEGDGQGGSGGEE---------GSFIWVERVTLSEEWEELLVEGLEGPE 365
EG+ + EG+G+ GEE G ER E+ EE +G EG E
Sbjct: 740 EEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG-EGEE 798
Query: 366 VAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER 425
RG+E EG + GGE +R+ EE G G EE+ G G +E E
Sbjct: 799 EETEGRGEEKE---EGGEVEGGEVEEGKGEREEEEEEGEGEEEE-GEGEEE-------EG 847
Query: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
+G E+ E G E+ G E EG EE G E + EG E EG+ E+ G E E EE
Sbjct: 848 EGEEE----EGEGKGEEEGEEGEGEEE--GEEGEGEGE-EEEGEGEGEEEGEGEGEEEEG 900
Query: 486 LGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSR 545
G GEEE E E E E KG EE E E G EE E E G EG+ E+G
Sbjct: 901 EG----EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG-EGEGEEEEGEW 955
Query: 546 EGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQG 600
EG E + E E E E EG +E+ G EEE + + EG+G
Sbjct: 956 EGEEEEGEGEGE-----EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEG 1005
Score = 97.1 bits (240), Expect = 5e-20
Identities = 124/454 (27%), Positives = 179/454 (39%), Gaps = 72/454 (15%)
Query: 249 LEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRV----PEVVQTSSP 304
+EA D + +E+P +E G + G+ + EA E +V E + S
Sbjct: 576 IEAFSDEE----VEIP---EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD 628
Query: 305 RLQERLEA----AASI-EGEDVPQGSPEGDGQGGSGGEEGSFIWVER------------- 346
L ++ E A S+ E ED P+G +G + GS G E W +
Sbjct: 629 DLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEH---WQDEEREKGEKDKGRGE 685
Query: 347 ----------VTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKR 396
+ EEW++ E E E RE+G + E + GG EE E E+
Sbjct: 686 MERPGEGEKELAEKEEWKKRDGEEQEQKE---REQGHQKERNQE-MEEGGEEEHGEGEEE 741
Query: 397 KAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREG---GEEP 453
+ + EEK G G++E E V GE++ E R E+ G E +G G++
Sbjct: 742 EGDREE---EEEKEGEGKEEGEGEEVE----GEREKEEGERKKEERAGKEEKGEEEGDQG 794
Query: 454 LGIERKVEGHLRAEKEGDEEKRG------AEEEEVEEPLGVEKKGGEEEPEATKEPLEAE 507
G E + EG ++EG E + G E EE EE E +G EEE E +E E E
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE----EGEGEEEEGEGEEEEGEGE 850
Query: 508 RKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREG---SESQAEEMNEAGPPLEA 564
+ GE E E GEE E+ + EG+ E+G EG E + EE G E
Sbjct: 851 EEEGEGKGEEE---GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
Query: 565 NTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPL 624
E+EG E+ E EG + + EG+ G+ E E+ E +
Sbjct: 908 GEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967
Query: 625 LQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEE 658
+GEG E EGEE
Sbjct: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEE 1001
Score = 83.6 bits (205), Expect = 6e-16
Identities = 104/325 (32%), Positives = 135/325 (41%), Gaps = 54/325 (16%)
Query: 283 GSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEG----EDVPQGSPE-GDGQGGSGGE 337
G + E GE+ EV + R +E E E E+ +G E G+G+G GE
Sbjct: 805 GEEKEEGGEV-EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
Query: 338 EGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGA--EGAKTGGGEETWEAEK 395
EG EE EE EG EG E G G+E G E G GEE E E
Sbjct: 864 EGEG--------EEEGEE--GEG-EGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912
Query: 396 RKAEESMGIGSEE-KPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPL 454
+ EE G G EE + G G E E GE + E + G E+ E EG EE
Sbjct: 913 EE-EEGEGKGEEEGEEGEGEGEEE--------EGEGEGE-DGEGEGEEEEGEWEGEEE-- 960
Query: 455 GIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEET 514
E EG+EE G EE E +G EEE E E E E +G EE
Sbjct: 961 ----------EGEGEGEEEGEGEGEEG-------EGEGEEEEGEGEGEEEEGEEEGEEEG 1003
Query: 515 LEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEG 574
E E+ G E E E+ + EG++ E+G EG E EE E G E E +
Sbjct: 1004 -EGEEEGEGEGEEEEEGE-VEGEVEGEEGEGEGEE---EEGEEEGEEREKEGEGEENRRN 1058
Query: 575 PQPQEKPVGALEEEGVKPQTAAEGQ 599
+ +E+ G +E G + +G+
Sbjct: 1059 REEEEEEEGKYQETGEEENERQDGE 1083
Score = 82.0 bits (201), Expect = 2e-15
Identities = 116/372 (31%), Positives = 150/372 (40%), Gaps = 54/372 (14%)
Query: 205 SEGRVGEAKGGGVVS--VVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDR-KGAGSL 261
+EGR E + GG V V EG E+ G E E + EE E + +G G
Sbjct: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860
Query: 262 ELPAWVKEDRGIV------EVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAAS 315
E E+ G E EG G + E GE +E E
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE---------------EEEGEGEGE 905
Query: 316 IEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGL-EGPEVAGRERGDE 374
EGE + EG+G+G GEEG E EE E +G EG E G G+E
Sbjct: 906 EEGEGEGE-EEEGEGKGEEEGEEG-----EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEE 959
Query: 375 SPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKG-GEKKLE 433
EG + G GE + + EE G G EE+ G +E E E +G GE + E
Sbjct: 960 EEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEE---GEEEGEEEGEGEEEGEGEGEEE 1016
Query: 434 LESRGSAEKLGTEREG-GEEPLGIERKVEGHLRA-EKEGDEEKRGAEEEEVEEPLGVEKK 491
E E G E EG GEE G E EG R E EG+E +R EEEE EE G ++
Sbjct: 1017 EEGEVEGEVEGEEGEGEGEEEEGEE---EGEEREKEGEGEENRRNREEEEEEE--GKYQE 1071
Query: 492 GGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSES- 550
GEE E ER+ GEE + K G KT + N + +E
Sbjct: 1072 TGEE---------ENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKM 1122
Query: 551 --QAEEMNEAGP 560
Q++ + + GP
Sbjct: 1123 PVQSKRLLKNGP 1134
Score = 81.3 bits (199), Expect = 3e-15
Identities = 99/307 (32%), Positives = 126/307 (41%), Gaps = 26/307 (8%)
Query: 245 EEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSP 304
EE E G+ K G V+E +G E E G + E GE +
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856
Query: 305 RLQERLEAAASIEGEDVPQGSPEGDGQG------GSGGEEGSFIWVERVTLSEEWEELLV 358
+ +E E EGE +G EG+G+G G G EEG E E EE
Sbjct: 857 KGEEEGE-----EGEGEEEGE-EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910
Query: 359 EGLEGP-EVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEA 417
EG E E G E G+E EG + G E + E EE EE+ G G E
Sbjct: 911 EGEEEEGEGKGEEEGEEGE--GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
Query: 418 EMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIER-------KVEGHLRAEKEG 470
E E GE + E E G E+ E EG EE G E + EG + E EG
Sbjct: 969 EGEGEGEEGEGEGEEE-EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG 1027
Query: 471 DE-EKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEET--LEAEKRGGEESLE 527
+E E G EEE EE EK+G EE +E E E +ET E E++ GEE +
Sbjct: 1028 EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKK 1087
Query: 528 TEKTQGT 534
K +G+
Sbjct: 1088 VSKIKGS 1094
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 77.0 bits (188), Expect = 5e-14
Identities = 78/332 (23%), Positives = 141/332 (42%), Gaps = 32/332 (9%)
Query: 347 VTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGS 406
+ + E + +VE E V E+ +E+ + E + EE EA++ + +E G G
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTE----EEEKEAKEEEGKEEEG-GE 490
Query: 407 EEKPGTGRDEAEMSPVVERKGGEKK----LELESRGSAEKLGTEREGGEEPLGIE--RKV 460
EE+ G +E + P E EK+ ++ E++ AE E+E + P ++ K
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 461 EGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKR 520
+ + E + E + E+EE + P V+ PE K P + E K E EK
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKS------PEKAKSPAKEEAKSPAEAKSPEK- 603
Query: 521 GGEESLETEKTQGTEGDLNLEQGSREGSESQAEE------MNEAGPPLEANTETRPEKEG 574
+ ++ E E +++ ++ +E ++ E EA P +A + + E +
Sbjct: 604 -AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 575 PQPQEKPV--GALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSA 632
P+ + PV A E K AE + P +P+ E +PE+ P+ + +
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK--SPVKE---EAK 717
Query: 633 NPSAHPVPTYAPARQPEPSAPTEGEEASGPKQ 664
+P P A+ PE + EEA P++
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
Score = 64.3 bits (155), Expect = 3e-10
Identities = 90/358 (25%), Positives = 137/358 (38%), Gaps = 43/358 (12%)
Query: 319 EDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLG 378
E+ + + E +G+ GGEE E T S EE A E+ +SP+
Sbjct: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE----------AASPEKEAKSPVK 521
Query: 379 AEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRG 438
E E EK +A+ + S EK + E SP E K EK+ E++
Sbjct: 522 EEAKSPA---EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP-EAKSPEKE---EAKS 574
Query: 439 SAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEE--- 495
AE E+ + P K E AE + E+ + +EE + P + EE
Sbjct: 575 PAEVKSPEK--AKSPA----KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 496 -----EPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSES 550
PE K P + E K E+ EK EE+ EK + + E S E ++S
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEK---EEAKSPEK---AKSPVKAEAKSPEKAKS 682
Query: 551 QAEEMNEAGPPLEANTETRPEKEGPQPQEKPV--GALEEEGVKPQTAAEGQGPLGDATPL 608
+ EA P +A + + E + P+ + PV A E K E + P +P+
Sbjct: 683 PVKA--EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740
Query: 609 LAETPAPE--QPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQ 664
E +PE + E L + P A A + PE + EE P++
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Score = 58.2 bits (139), Expect = 2e-08
Identities = 123/604 (20%), Positives = 237/604 (39%), Gaps = 65/604 (10%)
Query: 13 VIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQS 72
VI E++ + ++ E EE++ + E K + E +G E ++ P +++ S
Sbjct: 455 VIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE---EETKSPPAEEAAS 511
Query: 73 PEGQAQARIRNLEDSLFTLQS----------QLQLLQSASTGAQHKPSGRPSWRR-QGHR 121
PE +A++ ++ S +S +++ + A + A+ + P + +
Sbjct: 512 PEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE 571
Query: 122 PLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSS 181
S + V++ ++ + A PA +P ++ S +E+ V A +
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAE-AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630
Query: 182 EANGPCPSPIPTPEQGLSQRAVPS----EGRVGEAKGGGVVSVVWEGLRATEDCATGATG 237
E P + PT E+ S S E + E V + +A A
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 238 PELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPE 297
PE K + V E + K + P VKE+ E V + E + P
Sbjct: 691 PE---KAKSPVKE---EAKSPEKAKSP--VKEEAKSPEKAKSPV--KEEAKTPEKAKSPV 740
Query: 298 VVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELL 357
+ SP + E A +++ + P+ + S ++ E+ + +
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKS-PEAKTPAKEEARSPADK----------FPEKAKSPV 789
Query: 358 VEGLEGPEVAGRERGDESPLGAEGAKTGGGE----ETWEAEKRKAEESMGIGSEEKPGTG 413
E ++ PE A +SPL E AK E E ++ ++ E+ + +E P
Sbjct: 790 KEEVKSPEKA------KSPL-KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA 842
Query: 414 RDE-AEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDE 472
+E A +P E K KK E + + + E+ +EP +E+ E + A+KE E
Sbjct: 843 EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK---KEP-AVEKPKESKVEAKKEEAE 898
Query: 473 EKRGAEEEEVEEPLGVEKKGGEEEPEAT----KEPLEAERKGGEETLEAEKRGGE-ESLE 527
+K+ E E P VE K + E T KEP +A+ K + E ++ E + +
Sbjct: 899 DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958
Query: 528 TEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEE 587
EK + E E ++E ++ ++E ++ + + +K+ P++ A E+
Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK----ATED 1014
Query: 588 EGVK 591
+ K
Sbjct: 1015 KAAK 1018
Score = 55.1 bits (131), Expect = 2e-07
Identities = 70/308 (22%), Positives = 122/308 (39%), Gaps = 32/308 (10%)
Query: 374 ESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLE 433
+SP+ AE + +AE + E++ EE E SPV E +K +
Sbjct: 667 KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP---EKAKSPVKEEAKSPEKAK 723
Query: 434 LESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEK---EGDEEKRGAEEE---------- 480
+ A+ + +E K + +A+ + E K A+EE
Sbjct: 724 SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
Query: 481 EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNL 540
+ + P+ E K PE K PL+ + K E+ + ++ E EK Q ++ +
Sbjct: 784 KAKSPVKEEVKS----PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ----EVKV 835
Query: 541 EQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQP--QEKPVGALEEEGVKPQTAAEG 598
++ ++ E +A + ++ E P+KE P+P +EK A+E+ A +
Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895
Query: 599 QGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEE 658
+ P TP E PA+ + + A P A A+ EPS P E +E
Sbjct: 896 EAEDKKKVP----TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK--EPSKPAEKKE 949
Query: 659 ASGPKQKT 666
A+ K+ T
Sbjct: 950 AAPEKKDT 957
Score = 46.2 bits (108), Expect = 1e-04
Identities = 96/493 (19%), Positives = 177/493 (35%), Gaps = 40/493 (8%)
Query: 57 AVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWR 116
A E P +K P+ E ++ A +++ E + + + + A + + K + +
Sbjct: 554 AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 117 R--QGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEP-REDVLGFLPGPRQV 173
+ P+ + EA S + ++A P PE P +E+ V
Sbjct: 614 SPAEAKSPVKE---EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 174 PGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCAT 233
A +A P + +PE+ S V E + E V +A
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSP--VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 234 GATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIG 293
A PE K + V E + A S E + + + S A+ E
Sbjct: 729 EAKTPE---KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 294 RVPEVVQTSSP-RLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEE 352
+ P + SP + + L+ A +++P+ + + EE
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV------------------KSPVKEE 827
Query: 353 WEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEET--WEAEKRKAEE----SMGIGS 406
+ V+ E P+ A E+ +P E K EE EA K K EE ++
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPK-TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPK 886
Query: 407 EEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRA 466
E K ++EAE V E ++E + A+ +EP + K
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 467 EKEGDEEKRGAEEEEV---EEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGE 523
+KE EK+ +EE+ EE E K E++ +KEP + + + E++ +++ +
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Query: 524 ESLETEKTQGTEG 536
+ + + +G
Sbjct: 1007 PPEKATEDKAAKG 1019
>gi|8923243 palmdelphin [Homo sapiens]
Length = 551
Score = 73.9 bits (180), Expect = 4e-13
Identities = 39/101 (38%), Positives = 64/101 (63%), Gaps = 6/101 (5%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
M E+ L + RL+ I +KR++QEEI R ++EE+KL+ + LK+K+LRE+WL+DG ++ E
Sbjct: 1 MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKKALREKWLLDGISSGKE 60
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSA 101
E + Q Q +I+ LE S+ L+ ++Q L+ A
Sbjct: 61 QEE------MKKQNQQDQHQIQVLEQSILRLEKEIQDLEKA 95
>gi|82617626 paralemmin 2 isoform b [Homo sapiens]
Length = 379
Score = 71.2 bits (173), Expect = 3e-12
Identities = 38/100 (38%), Positives = 66/100 (66%), Gaps = 4/100 (4%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
MAE+ L+++RL+ IAEKR+ Q EI R++++E+ L ++ K K LRE+WL+ G A
Sbjct: 3 MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA--G 60
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQS 100
+E+ ++ QS E + R++ LED++ L+ ++Q L+S
Sbjct: 61 TAEEEEARRRQSEED--EFRVKQLEDNIQRLEQEIQTLES 98
>gi|82524851 paralemmin 2 isoform a [Homo sapiens]
Length = 413
Score = 71.2 bits (173), Expect = 3e-12
Identities = 38/100 (38%), Positives = 66/100 (66%), Gaps = 4/100 (4%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
MAE+ L+++RL+ IAEKR+ Q EI R++++E+ L ++ K K LRE+WL+ G A
Sbjct: 3 MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA--G 60
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQS 100
+E+ ++ QS E + R++ LED++ L+ ++Q L+S
Sbjct: 61 TAEEEEARRRQSEED--EFRVKQLEDNIQRLEQEIQTLES 98
>gi|22325356 PALM2-AKAP2 protein isoform 2 [Homo sapiens]
Length = 1090
Score = 71.2 bits (173), Expect = 3e-12
Identities = 38/100 (38%), Positives = 66/100 (66%), Gaps = 4/100 (4%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
MAE+ L+++RL+ IAEKR+ Q EI R++++E+ L ++ K K LRE+WL+ G A
Sbjct: 1 MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA--G 58
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQS 100
+E+ ++ QS E + R++ LED++ L+ ++Q L+S
Sbjct: 59 TAEEEEARRRQSEED--EFRVKQLEDNIQRLEQEIQTLES 96
>gi|6005709 PALM2-AKAP2 protein isoform 1 [Homo sapiens]
Length = 1103
Score = 71.2 bits (173), Expect = 3e-12
Identities = 38/100 (38%), Positives = 66/100 (66%), Gaps = 4/100 (4%)
Query: 1 MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60
MAE+ L+++RL+ IAEKR+ Q EI R++++E+ L ++ K K LRE+WL+ G A
Sbjct: 1 MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA--G 58
Query: 61 PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQS 100
+E+ ++ QS E + R++ LED++ L+ ++Q L+S
Sbjct: 59 TAEEEEARRRQSEED--EFRVKQLEDNIQRLEQEIQTLES 96
>gi|93141029 paralemmin isoform 2 [Homo sapiens]
Length = 343
Score = 70.5 bits (171), Expect = 5e-12
Identities = 35/98 (35%), Positives = 63/98 (64%), Gaps = 4/98 (4%)
Query: 2 AESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEP 61
AE++ ++RL+ IAEKR+ Q EI RR++E+E+ +++ LK K+LRERWL++G +
Sbjct: 6 AETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASE 65
Query: 62 SEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQ 99
++ + Q E + R LEDS+ L+ ++++L+
Sbjct: 66 GDEDLRRQMQDDE----QKTRLLEDSVSRLEKEIEVLE 99
Score = 38.9 bits (89), Expect = 0.016
Identities = 51/183 (27%), Positives = 69/183 (37%), Gaps = 27/183 (14%)
Query: 497 PEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSRE--GSESQAEE 554
P ++ E E K E TL G + E EG RE G ++Q E
Sbjct: 182 PLSSSEVDELIHKADEVTLS---EAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGE 238
Query: 555 MNEAGPPLEANTETRPEKEGPQP-QEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETP 613
+GPP G QP QE PV + + AE + LG + AE
Sbjct: 239 AT-SGPP------------GIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELV 285
Query: 614 APEQPAECQPLLQGEGPSANPSAHPVPTYAPAR---QPEPSAPTEGEEASGPKQKTCQCC 670
E AE + G +A P PT A +R Q P A T + K+ C+CC
Sbjct: 286 VIEDAAEPKEPAPPNGSAAEP-----PTEAASREENQAGPEATTSDPQDLDMKKHRCKCC 340
Query: 671 AVM 673
++M
Sbjct: 341 SIM 343
>gi|93141031 paralemmin isoform 1 [Homo sapiens]
Length = 387
Score = 70.5 bits (171), Expect = 5e-12
Identities = 35/98 (35%), Positives = 63/98 (64%), Gaps = 4/98 (4%)
Query: 2 AESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEP 61
AE++ ++RL+ IAEKR+ Q EI RR++E+E+ +++ LK K+LRERWL++G +
Sbjct: 6 AETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASE 65
Query: 62 SEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQ 99
++ + Q E + R LEDS+ L+ ++++L+
Sbjct: 66 GDEDLRRQMQDDE----QKTRLLEDSVSRLEKEIEVLE 99
Score = 40.4 bits (93), Expect = 0.005
Identities = 84/368 (22%), Positives = 129/368 (35%), Gaps = 50/368 (13%)
Query: 319 EDVPQGSPEGDG---QGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDES 375
E P + EGD + E+ + + + V+ E+ E+L G P A S
Sbjct: 57 EGTPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPS 116
Query: 376 PLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEK-PGTGRDEAEMSPVVERKGGEKKLEL 434
P+ A E E + +G +++ T + SP+++ ++ +
Sbjct: 117 PVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITV 176
Query: 435 ES---RGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKK 491
E G L + +PL + KV E + V G +
Sbjct: 177 EKDKVTGETRVLSSTTLLPRQPLPLGIKVYED--------------ETKVVHAVDGTAEN 222
Query: 492 GGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSRE--GSE 549
G P ++ E E K E TL G + E EG RE G +
Sbjct: 223 G--IHPLSSSEVDELIHKADEVTLS---EAGSTAGAAETRGAVEGAARTTPSRREITGVQ 277
Query: 550 SQAEEMNEAGPPLEANTETRPEKEGPQP-QEKPVGALEEEGVKPQTAAEGQGPLGDATPL 608
+Q E +GPP G QP QE PV + + AE + LG +
Sbjct: 278 AQPGEAT-SGPP------------GIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTI 324
Query: 609 LAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPAR---QPEPSAPTEGEEASGPKQK 665
AE E AE + G +A P PT A +R Q P A T + K+
Sbjct: 325 TAELVVIEDAAEPKEPAPPNGSAAEP-----PTEAASREENQAGPEATTSDPQDLDMKKH 379
Query: 666 TCQCCAVM 673
C+CC++M
Sbjct: 380 RCKCCSIM 387
>gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
Length = 1088
Score = 69.3 bits (168), Expect = 1e-11
Identities = 122/441 (27%), Positives = 179/441 (40%), Gaps = 82/441 (18%)
Query: 222 WEGLRATEDCATGATGPELEA---KVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVV- 277
W G TE A GA GP+ ++E+ V EA AG E P +G VV
Sbjct: 202 WHG--ETEGKA-GAVGPKAAGDNREMEQGVREA-----DAGETEEPGAEGAGKGEEVVVV 253
Query: 278 ---------WEGVG-GSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPE 327
W G G++ E G +GR E +T+ R EA A ++GE+ S
Sbjct: 254 EKACESTRAWGTWGPGAEPEDWGILGR--EEARTTPGRE----EARAILDGEEARTISGG 307
Query: 328 GDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTG-- 385
+ + SGGEE E + EE G E AG G E+ + G + G
Sbjct: 308 EEAETASGGEE-----AETASGGEE-----AGTASGGEEAGIASGGEAGTASGGEEAGTA 357
Query: 386 -GGEETWEAEKRKAEESMGIGSEE---KPGTGRDEAEMSPVVERKGGEKKLELESR---G 438
GG+E W ++ + +G+ E PG EA V + G+++ E E
Sbjct: 358 SGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPK 417
Query: 439 SAEKLGTER--EGGEEPLGIERKVEGHLRAEK-EGDEEKRGAEEEEVEEPLGV------- 488
+ LGTER E E V G E EG + RG +E E+ + LG+
Sbjct: 418 QPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRG-KEAEMRQDLGIRADRARM 476
Query: 489 ----------EKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESL---ETEKTQGTE 535
E++G +P A + P + E +G + + EE L E+E Q +
Sbjct: 477 EELVQAEEAQEERGSSRDPVA-ELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSC 535
Query: 536 GDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTA 595
G L +E G S ++ + GP L +T P K QP+E+ G +E GV +
Sbjct: 536 GLLGVEWGGLTHSVTKGQ-----GPELMGGAQT-PTK---QPEEREAGEVELMGVLALSK 586
Query: 596 AEGQGPLGDATPLLAETPAPE 616
E + L +A P A + PE
Sbjct: 587 EEQERSL-EAGPRHAGSVKPE 606
Score = 57.4 bits (137), Expect = 4e-08
Identities = 99/400 (24%), Positives = 146/400 (36%), Gaps = 60/400 (15%)
Query: 314 ASIEGEDVPQGSPEGD-GQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPE------- 365
A+ + ++ QG E D G+ G EG+ E V + + E G GP
Sbjct: 217 AAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWG 276
Query: 366 VAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER 425
+ GRE +P E GEE + E+ G E + +G +EA + E
Sbjct: 277 ILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEE 336
Query: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
G E + E+ GT GG+E K E L ++ E E + E
Sbjct: 337 AGIASGGEAGTASGGEEAGT-ASGGDEAWTTSGKEEADLLGVRQ--TEYGAVPGERLLEA 393
Query: 486 LG----VEKKGGEE-EPEATKEPLEAERKGGEETLEA--------EKRGGEESLETEKTQ 532
G +E++G EE E E + P + + G E T EA E GG+E+ E+ + Q
Sbjct: 394 TGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQ 453
Query: 533 ----GTEGDLNLEQGSR----------EGSESQAEEMNEAGP--------------PLEA 564
G E ++ + G R + E+Q E + P LEA
Sbjct: 454 VDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEA 513
Query: 565 NTETRPEK----EGPQPQEKPVGALEEE-GVKPQTAAEGQGPL---GDATPLLAETPAPE 616
E RPE+ E + + G L E G + +GQGP G TP
Sbjct: 514 TPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREA 573
Query: 617 QPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEG 656
E +L S P +A + +PE S G
Sbjct: 574 GEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPG 613
Score = 57.0 bits (136), Expect = 6e-08
Identities = 167/661 (25%), Positives = 244/661 (36%), Gaps = 82/661 (12%)
Query: 8 RQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTS 67
RQ L + A++ R++E ++A E +EE R S R D A +P E +
Sbjct: 464 RQDLGIRADRARMEELVQA--EEAQEE--------RGSSR-----DPVAELPSDGEAEGT 508
Query: 68 KDPQS-PEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQS 126
D ++ PE + + + E Q+ LL G H + G
Sbjct: 509 ADLEATPEARPEEELTGEESE--AAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTK 566
Query: 127 IVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEA-NG 185
E G+ +L G++ E E GPR ++SEA G
Sbjct: 567 QPEEREAGEVEL-------MGVLALSKEEQERSLE------AGPRHAGSVKPEASEAFPG 613
Query: 186 PCPSPIPTP-EQGLSQR-AVPSEGRVGEAKGGG-VVSVVWEGLRATEDCATGATGPELEA 242
+ E+G +Q A E R E GG ++ EG R +E G E
Sbjct: 614 AWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLT 673
Query: 243 KVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEV---V 299
+ G+ + + EL D G + E + E R +
Sbjct: 674 TQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRL 733
Query: 300 QTSSPRLQERLEA-----AASIEGEDV-PQGSPEGDGQGGSG--GEEGSFIWVERVTLSE 351
Q + L +R +A AA I G DV P S G G+ G G+ E E
Sbjct: 734 QAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGE 793
Query: 352 E--WEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEK 409
+E +EG EV GR E+ EG GG E E AE+S G+ +
Sbjct: 794 HAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEA--EESAGAEDSCGL---DP 848
Query: 410 PGTGRDEAE-MSPVVERKGGEKK---LELESRGSAEKLGTEREGGEEPLGI---ERKVEG 462
G+ AE M +VE G +K LE E+ G E+ +RE E G E +
Sbjct: 849 AGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQER--EQREDSEGRCGDYHPEGEAPR 906
Query: 463 HLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEA--ERKGGEETLEA--E 518
L AE R AE +E E P +E G+EE + P EA E G ET EA
Sbjct: 907 LLDAEGLMVTGGRRAEAKETE-PESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGS 965
Query: 519 KRGGEESLETE-KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQP 577
RGG + +E G+ D+++ + S S ++ + E + E P P
Sbjct: 966 ARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNP 1025
Query: 578 QEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAH 637
E+ + A E+ ++ + E D TP+ PA +PL G G AH
Sbjct: 1026 PEEELSAPEQRPLQLEEPLEPSPLRHDGTPV---------PARRRPLGHGFG-----LAH 1071
Query: 638 P 638
P
Sbjct: 1072 P 1072
Score = 49.3 bits (116), Expect = 1e-05
Identities = 126/520 (24%), Positives = 190/520 (36%), Gaps = 78/520 (15%)
Query: 160 REDVLGFLPGPRQVPGAAG------DSSEANGPCPSPIPTPEQGL----SQRAVPSEGRV 209
R+ G +PG R + + E SP P Q L ++ A S+
Sbjct: 378 RQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAG 437
Query: 210 GEAKGGGVVSVVWEG---LRATEDCATGATGPELE-AKVEEVVLEAIGDRKGAGSLELPA 265
EA GG +EG LR E G + A++EE+V + S + A
Sbjct: 438 REAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVA 497
Query: 266 WVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGS 325
+ D E G +D EA E E+ S Q +E +
Sbjct: 498 ELPSDG-------EAEGTADLEATPEARPEEELTGEESEAAQTSC-GLLGVEWGGLTHSV 549
Query: 326 PEGDGQGGSGG-----------EEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDE 374
+G G GG E G + + LS+E +E +E GP AG + +
Sbjct: 550 TKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEA--GPRHAGSVKPEA 607
Query: 375 SPL--GAEGAKT-------GGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER 425
S GA +T E+ + E+R+ EE+ G + G E+E+S V E
Sbjct: 608 SEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPE- 666
Query: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAE-----KEGDEEKRGAEEE 480
GGE + + G E GE + ++++G A+ G+ R E+E
Sbjct: 667 AGGEGL-------TTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDE 719
Query: 481 EVEEP--------LGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQ 532
E E L G + +A + A GG+ G E+LE Q
Sbjct: 720 EAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQ 779
Query: 533 GTEGDLNLEQGSRE---GSE-----SQAEEMNEAGPPLEANTETRPEKEGPQPQ-EKPVG 583
G + E + E G E S EE+ G +EA G + + E+ G
Sbjct: 780 GWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAG 839
Query: 584 ALEEEGVKP---QTA-AEGQGPLGDATPLLAETPAPEQPA 619
A + G+ P QTA AEG G + +A LL + E+ A
Sbjct: 840 AEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEA 879
Score = 42.7 bits (99), Expect = 0.001
Identities = 79/287 (27%), Positives = 105/287 (36%), Gaps = 44/287 (15%)
Query: 369 RERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSE-EKPGTGRDEAEMSPVVERKG 427
R+ E + E +E E E R E M G+E E G E + V +
Sbjct: 159 RQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAA 218
Query: 428 GEKKLELE------SRGSAEKLGTEREG-GEEPLGIERKVEGHLRAEKEGDEEKRGAEEE 480
G+ + E+E G E+ G E G GEE + +E+ E G GAE E
Sbjct: 219 GDNR-EMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGP----GAEPE 273
Query: 481 EVEEPLGVEK---KGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEK------T 531
+ LG E+ G EE A + EA G E EAE G E ET T
Sbjct: 274 D-WGILGREEARTTPGREEARAILDGEEARTISGGE--EAETASGGEEAETASGGEEAGT 330
Query: 532 QGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTET----------RPEKEGPQPQEK- 580
+ + G G+ S EE A EA T + R + G P E+
Sbjct: 331 ASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERL 390
Query: 581 -----PVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQ 622
V LEEEG + + A P P + T E+ AE Q
Sbjct: 391 LEATGKVWVLEEEGDEEREAEVSPFP---KQPQVLGTERTEEAAESQ 434
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 67.8 bits (164), Expect = 3e-11
Identities = 128/544 (23%), Positives = 201/544 (36%), Gaps = 72/544 (13%)
Query: 168 PGPRQVPGAAGDSSEANGPCPSPI---------PTPEQGLSQRAVPSEGRVGEAKGGGVV 218
PGP PG + EA+ P SP+ P E LSQ S + ++
Sbjct: 464 PGPGLGPGPPDEKLEAS-PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSS--- 519
Query: 219 SVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAG------SLELPAWVKEDRG 272
W G E A G ++ + + + G G S+E P +D
Sbjct: 520 EPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPL---DDLS 576
Query: 273 IVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRL-QERLEAAASIEGEDVP----QGSPE 327
+ E + V ++ G PEV + + + + + + G P GS E
Sbjct: 577 LDEAQF--VLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLE 634
Query: 328 GDGQG------GSGGEEGSFIWVERVTLSEEWEELLV-EGLEG-PEV---AGRERGDESP 376
G+ G G GGEE + V +E L + E EG PE AG+ D
Sbjct: 635 GEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGE 694
Query: 377 LGAEGA-----KTGGGEETWEAEKR----KAEESMGIGSEEKPGTGRDEAEMSPVVERKG 427
G + G EET E++ K +SM E+PG E +ER+
Sbjct: 695 AGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREE 754
Query: 428 GEKKLE--LESRGSAEKLGTEREGGEEPLGIERKVEGH-LRAEKEGDEEKRGAEEEEVEE 484
E++ E +E+ E+ E + EE + +K E +R +++ + ++G E ++
Sbjct: 755 DEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQ 814
Query: 485 PLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGS 544
G + + E E + ER+ G+ E ++R G LE + G +LE
Sbjct: 815 GDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDC 874
Query: 545 REGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGD 604
+ + EM E P +PE+ P+ Q P G L + G G +G
Sbjct: 875 AKEGNPHSSEMEEVAP-----QPPQPEEMEPEGQPSPDGCL-------CPCSLGLGGVG- 921
Query: 605 ATPLLAETPAPEQPAECQPLLQ-----GEGPSANPSAHPVPTYAPARQPEPSAPTEGEEA 659
LA T Q P++ + PSA S V P +P T GE A
Sbjct: 922 --MRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERA 979
Query: 660 SGPK 663
G +
Sbjct: 980 WGSR 983
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 67.0 bits (162), Expect = 5e-11
Identities = 90/322 (27%), Positives = 133/322 (41%), Gaps = 38/322 (11%)
Query: 362 EGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDE-AEMS 420
EGPE G E +E+P GA K GG + +A + G E + G E AE+
Sbjct: 39 EGPE--GSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVP 96
Query: 421 PVVERKGGEKKLELESRG---SAEKLGTEREGGEEPLGIERKVEGHLRAE-KEGDEEKRG 476
E G +++E S G E G + E+ ER+ E R E EG
Sbjct: 97 QGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEA 156
Query: 477 AEEEEVEEPLG--VEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETE----- 529
+ + E PLG +E +G + +EAE + G ++++AE G +S++ E
Sbjct: 157 GDSVDAEGPLGDNIEAEG------PAGDSVEAEGRVG-DSVDAEGPAG-DSVDAEGPLGD 208
Query: 530 --KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEE 587
+ +G GD +++ R G AE AG ++A E P G E
Sbjct: 209 NIQAEGPAGD-SVDAEGRVGDSVDAE--GPAGDSVDAEGRVGDSVEAGD----PAGDGVE 261
Query: 588 EGVKPQTAAEGQGPLGDATPLLAETPAPE-QPAECQPLLQGEGPSANPSAHPVPTYA--- 643
GV + E +GP GD+ + AE PA + +P G+G S +P A + A
Sbjct: 262 AGVPAGDSVEAEGPAGDS--MDAEGPAGRARRVSGEPQQSGDG-SLSPQAEAIEVAAGES 318
Query: 644 PARQPEPSAPTEGEEASGPKQK 665
R P A EEA P K
Sbjct: 319 AGRSPGELAWDAAEEAEVPGVK 340
Score = 65.9 bits (159), Expect = 1e-10
Identities = 129/491 (26%), Positives = 181/491 (36%), Gaps = 82/491 (16%)
Query: 142 ASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQR 201
A+ P G+ P P P L PG PGAAG +E P +G ++
Sbjct: 4 AAEPEGVAPGPQGPPEVPAP--LAERPGE---PGAAGGEAEG--------PEGSEG-AEE 49
Query: 202 AVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSL 261
A V EA GGG R E A G G E + EE G +GA
Sbjct: 50 APRGAAAVKEAGGGGPD-------RGPEAEARGTRGAHGETEAEE------GAPEGA--- 93
Query: 262 ELPAWVKEDRGIVEVVWEGVG-GSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGED 320
E+P +E G +V G G+ E GE R PE +++P QE E + +
Sbjct: 94 EVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPE--DSAAPERQEEAE-----QRPE 146
Query: 321 VPQGSPEGDGQGG--SGGEEGSFIWVERVTL-SEEWEELLVEGLEGPEVAGRERGDESPL 377
VP+GS G+ + G G I E S E E + + ++ AG E PL
Sbjct: 147 VPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPL 206
Query: 378 GAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRD-EAEMSPVVER-----KGGEKK 431
G G ++ +AE R + + +E G D E + VE G E
Sbjct: 207 GDNIQAEGPAGDSVDAEGRVGDS---VDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAG 263
Query: 432 LELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKK 491
+ AE + E P G R+V G ++ GD G+ + E +E
Sbjct: 264 VPAGDSVEAEGPAGDSMDAEGPAGRARRVSGE--PQQSGD----GSLSPQAE---AIEVA 314
Query: 492 GGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQ 551
GE A + P E EE +G EE+ GD + G +
Sbjct: 315 AGES---AGRSPGELAWDAAEEAEVPGVKGSEEA--------APGDARADAGEDRVGDGP 363
Query: 552 AEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATP--LL 609
+E E E R E+ P+E+ EEE P ++ G+ G A P L
Sbjct: 364 QQEPGE--------DEERRERSPEGPREEEAAGGEEE--SPDSSPHGEASRGAAEPEAQL 413
Query: 610 AETPAPEQPAE 620
+ A E PAE
Sbjct: 414 SNHLAEEGPAE 424
Score = 50.8 bits (120), Expect = 4e-06
Identities = 97/391 (24%), Positives = 138/391 (35%), Gaps = 90/391 (23%)
Query: 175 GAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGE---AKGGGVVSVVWEGLRATEDC 231
G AGDS +A GP I +G + +V +EGRVG+ A+G SV EG
Sbjct: 154 GEAGDSVDAEGPLGDNIEA--EGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQ 211
Query: 232 ATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGE 291
A G G ++A+ +GD A EG G +A G
Sbjct: 212 AEGPAGDSVDAEGR------VGDSVDA--------------------EGPAGDSVDAEGR 245
Query: 292 IGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSE 351
+G + V+ P G+ V G P GD G S
Sbjct: 246 VG---DSVEAGDPA------------GDGVEAGVPAGDSVEAEGPAGDSM---------- 280
Query: 352 EWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRK--AEESMGIGSEEK 409
EGP AGR R + E ++G G + +AE + A ES G E
Sbjct: 281 --------DAEGP--AGRARR----VSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGEL 326
Query: 410 PGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKE 469
+EAE+ V KG E+ ++R A GE+ +G +G + E
Sbjct: 327 AWDAAEEAEVPGV---KGSEEAAPGDARADA---------GEDRVG-----DGPQQEPGE 369
Query: 470 GDEEK-RGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLET 528
+E + R E EE G E++ + P AE + AE+ E S E
Sbjct: 370 DEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEA 429
Query: 529 EKTQGTEGDLNLEQGSREGSESQAEEMNEAG 559
+ G D + G E +AG
Sbjct: 430 ARVNGRREDGEASEPRALGQEHDITLFVKAG 460
Score = 49.7 bits (117), Expect = 9e-06
Identities = 47/157 (29%), Positives = 64/157 (40%), Gaps = 39/157 (24%)
Query: 466 AEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEES 525
AE+ G+ GA E E P G E G EE P EA G + EAE RG
Sbjct: 25 AERPGEP---GAAGGEAEGPEGSE--GAEEAPRGAAAVKEAGGGGPDRGPEAEARG---- 75
Query: 526 LETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGAL 585
T+G G+ E+G+ EG+E PQ E+ GA
Sbjct: 76 -----TRGAHGETEAEEGAPEGAEV------------------------PQGGEETSGAQ 106
Query: 586 EEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQ 622
+ EG P A+G+ P G+A ++ APE+ E +
Sbjct: 107 QVEGASPGRGAQGE-PRGEAQREPEDSAAPERQEEAE 142
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/398 (25%), Positives = 142/398 (35%), Gaps = 66/398 (16%)
Query: 303 SPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGG----EE-----GSFIWVERVTLSEEW 353
S +E++E ED SP D SGG EE G I T S +
Sbjct: 12 SAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQ 71
Query: 354 EELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAE---ESMGIGSEEKP 410
E+ E E+ G G + + E + GG+E EAE +K + E +GS+E
Sbjct: 72 EKAPAEDGMSAELQGEANGLDE-VKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM- 129
Query: 411 GTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKE- 469
TGR E S E + E L E + + EK G + K E E+E
Sbjct: 130 -TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEED 188
Query: 470 ---GDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESL 526
+E+ G +E EP ++K +EE +A + E + E E + G EE+
Sbjct: 189 AKTASQEETGQRKECSTEP---KEKATDEEAKAESQKAVVEDEAKAEPKEPD--GKEEAK 243
Query: 527 ETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEG------PQPQEK 580
K E+ + AEE P E + E EG P+E
Sbjct: 244 HGAK----------EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEW 293
Query: 581 PVGA------LEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANP 634
P L +G+ P A GQ T A +P + P E PS+
Sbjct: 294 PESPTGEGHNLSTDGLGPDCVASGQ------TSPSASESSPSDVPQSPP----ESPSSGE 343
Query: 635 SAHPVP---TYAPARQPEPSAPTE-------GEEASGP 662
P APAR P A G ASGP
Sbjct: 344 KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGP 381
Score = 51.2 bits (121), Expect = 3e-06
Identities = 65/307 (21%), Positives = 116/307 (37%), Gaps = 27/307 (8%)
Query: 283 GSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFI 342
G AE GE + EV S + +A A ++ ED G +E + +
Sbjct: 79 GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED--------------GEKEETTV 124
Query: 343 WVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESM 402
+ +T +E E E E E ++ + AK G++ ++ K E
Sbjct: 125 GSQEMTGRKE--ETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
Query: 403 GIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEG 462
+ E+ ++E + EK + E++ ++K E E EP + K E
Sbjct: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
Query: 463 HLRAEKEGD--EEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKR 520
A++E D EE AEE E P +++ E+EPE + + + E+ E
Sbjct: 243 KHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGH 302
Query: 521 G------GEESLETEKTQGTEGDLNLEQGSREGSESQAE-EMNEAGPPLEANTETRPEKE 573
G + + + +T + + + + ES + E E P + RP
Sbjct: 303 NLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARP--R 360
Query: 574 GPQPQEK 580
GP+ Q +
Sbjct: 361 GPRAQNR 367
Score = 29.6 bits (65), Expect = 9.5
Identities = 33/152 (21%), Positives = 58/152 (38%), Gaps = 23/152 (15%)
Query: 26 AARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQAR----- 80
A++ E + K K K+ E + AV E D +P+ P+G+ +A+
Sbjct: 192 ASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE---DEAKAEPKEPDGKEEAKHGAKE 248
Query: 81 ----------IRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRR----QGHRPLSQS 126
E + + + + + GA PS W +GH +
Sbjct: 249 EADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDG 308
Query: 127 I-VEAGSVGQTDLNKRASLPAGLVGTPPESPS 157
+ + + GQT + S P+ + +PPESPS
Sbjct: 309 LGPDCVASGQTSPSASESSPSDVPQSPPESPS 340
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 63.5 bits (153), Expect = 6e-10
Identities = 76/279 (27%), Positives = 107/279 (38%), Gaps = 35/279 (12%)
Query: 395 KRKAEESMGIGSEEK---PGTGRDEAEMSPVVERKGGEK-------KLELESRGSAEKLG 444
KRK + SEEK P T +E E P E++ GE E RG + G
Sbjct: 896 KRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQ--G 953
Query: 445 TEREG-GEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKG-------GEEE 496
R+ + G E E ++E DEE E+E+ EE + KK EE
Sbjct: 954 KHRKSFALDSEGEEASQESSSEKDEEDDEEDE--EDEDREEAVDTTKKETEVSDGEDEES 1011
Query: 497 PEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMN 556
++K L A+ G E + ES + + + + S SES +E+
Sbjct: 1012 DSSSKCSLYADSDG-----ENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEE 1066
Query: 557 EAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPL--GDATPLLAETPA 614
E P + + P +E P P PV E V + A PL +A+P P
Sbjct: 1067 EEERPAALPSASPPPREVPVPTPAPV----EVPVPERVAGSPVTPLPEQEASPARPAGPT 1122
Query: 615 PEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAP 653
E P PL E P+ P+ P P P+ P P P
Sbjct: 1123 EESPPSA-PLRPPEPPAGPPAPAPRPDERPS-SPIPLLP 1159
Score = 46.6 bits (109), Expect = 7e-05
Identities = 70/316 (22%), Positives = 117/316 (37%), Gaps = 49/316 (15%)
Query: 380 EGAKTGGGEETWEAEKRKAEESMGIGS-----EEKPGTGRDEAEMSPVVE--RKGGEKKL 432
E G ++ WE+++ KA+ E+K T E + +V+ + GG +
Sbjct: 816 ENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGI 875
Query: 433 ELESRGS----AEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGV 488
E + GS A +L + + +EP I E EEKR EE
Sbjct: 876 EAFAFGSGLRGALRLPSFKVKRKEPSEIS-----------EASEEKRPRPSTPAEED--- 921
Query: 489 EKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEK-TQGTEGDLNLEQGSREG 547
E++PE KE E R G + E+RG + + +EG+ ++ S E
Sbjct: 922 -----EDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEK 976
Query: 548 SESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGA-------LEEEGVKPQTA----- 595
E EE E EA T+ E E +++ + + +G T+
Sbjct: 977 DEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESS 1036
Query: 596 AEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHP------VPTYAPARQPE 649
+ ++ + + + + + + E P+A PSA P VPT AP P
Sbjct: 1037 SSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPV 1096
Query: 650 PSAPTEGEEASGPKQK 665
P P+Q+
Sbjct: 1097 PERVAGSPVTPLPEQE 1112
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 63.5 bits (153), Expect = 6e-10
Identities = 62/198 (31%), Positives = 90/198 (45%), Gaps = 26/198 (13%)
Query: 471 DEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAER-KGGEETLEAEKRGGEESLETE 529
+E+K AEE+E EEP + EEE A K P++A + EE E E+ G+E E E
Sbjct: 486 EEKKEAAEEKE-EEP-----EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE-EEE 538
Query: 530 KTQGTEGDLNLEQGS-REGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEE 588
+ +G + D E GS +EGS + E E G ET E EG + + K +EE+
Sbjct: 539 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG-------ETEAEAEGEEAEAKEEKKVEEK 591
Query: 589 GVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQP 648
+ T E P A++P P+ P E +G S P + P + P
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVE------EKGKSPVPKS---PVEEKGKSP 642
Query: 649 EPSAPTEGEEASGPKQKT 666
P +P E E+ P K+
Sbjct: 643 VPKSPVE-EKGKSPVPKS 659
Score = 59.3 bits (142), Expect = 1e-08
Identities = 66/241 (27%), Positives = 114/241 (47%), Gaps = 27/241 (11%)
Query: 392 EAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGE 451
E EK + EE++ +EE + ++E + + E K E + E E +A+K + E
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEA--AEEKEEEPEAE-EEEVAAKKSPVKATAPE 519
Query: 452 --EPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEP--LEAE 507
E G + + EG ++E +EE GA+ ++ EE G EK+G E+ E +E EAE
Sbjct: 520 VKEEEGEKEEEEG----QEEEEEEDEGAKSDQAEEG-GSEKEGSSEKEEGEQEEGETEAE 574
Query: 508 RKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGS---ESQAEEMNEAGPPLEA 564
+G E + EK+ E+S E + D +E+ + S +S EE ++ P
Sbjct: 575 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP--- 631
Query: 565 NTETRPEKEGPQPQEKPVGALEEEGVKP----QTAAEGQGPLGDA-TPLLAETPAPEQPA 619
++ E++G P P +EE+G P +G+ P+ + A++P P+ P
Sbjct: 632 --KSPVEEKGKSP--VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 687
Query: 620 E 620
E
Sbjct: 688 E 688
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/204 (26%), Positives = 87/204 (42%), Gaps = 26/204 (12%)
Query: 472 EEKRGAEEEEVEEPLGVEKKGGEEE-------PEATKEPLEAERKGGEETLEAEKRGGEE 524
EEK+ A EE+ EEP E++ ++ PE +E E E + G+E E E G +
Sbjct: 486 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 545
Query: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGA 584
E EG E+G +E E++AE G EA E + E++ + K
Sbjct: 546 DQAEEGGSEKEGSSEKEEGEQEEGETEAE---AEGEEAEAKEEKKVEEKSEEVATKEELV 602
Query: 585 LEEEGVKPQTAAE--GQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTY 642
+ + KP+ A + P+ + ++P P+ P E +G S P + P
Sbjct: 603 ADAKVEKPEKAKSPVPKSPVEEK----GKSPVPKSPVE------EKGKSPVPKS---PVE 649
Query: 643 APARQPEPSAPTEGEEASGPKQKT 666
+ P P +P E E+ P K+
Sbjct: 650 EKGKSPVPKSPVE-EKGKSPVSKS 672
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)
Query: 452 EPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEE---------PLGVEKKGGEEEPEATKE 502
E L + K E AE++ EE+ AEEEEV P E++G +EE E +E
Sbjct: 478 EELAVSMKEEKKEAAEEK--EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 535
Query: 503 PLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQA-------EEM 555
E E G ++ +AE+ G E+ +EK +G + + E EG E++A E+
Sbjct: 536 --EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE-AEAEGEEAEAKEEKKVEEKS 592
Query: 556 NEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKP----QTAAEGQGPLGDA-TPLLA 610
E E + + EK P +EE+G P +G+ P+ +
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 652
Query: 611 ETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTE 655
++P P+ P E +G+ P + P A+ P P +P E
Sbjct: 653 KSPVPKSPVE----EKGKSPVSKS-----PVEEKAKSPVPKSPVE 688
Score = 52.4 bits (124), Expect = 1e-06
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 67/291 (23%)
Query: 347 VTLSEEWEELLVEGLEGPEVAGRE-RGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIG 405
V++ EE +E E E PE E +SP+ A + E E E+ + EE
Sbjct: 482 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE---- 537
Query: 406 SEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLR 465
EE G D+AE +GG +K GS+EK E+E GE E + EG
Sbjct: 538 -EEDEGAKSDQAE-------EGGSEK-----EGSSEKEEGEQEEGET----EAEAEGEEA 580
Query: 466 AEKEGDEEKRGAEEEEVEEPL-------------------GVEKKGGEEEPEA------- 499
KE + + +EE +E L VE+KG P++
Sbjct: 581 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGK 640
Query: 500 ---TKEPLEAERKGGEETLEAEKRGG--------EESLET--EKTQGTEGDLNLEQGSRE 546
K P+E + K E++G EE ++ K+ E E G E
Sbjct: 641 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 700
Query: 547 GSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAE 597
E + +E+ EA P E E + EK P++K E VK + AE
Sbjct: 701 QKEEEEKEVKEA--PKEEKVEKKEEKPKDVPEKKKA----ESPVKEEAVAE 745
Score = 47.4 bits (111), Expect = 4e-05
Identities = 99/411 (24%), Positives = 160/411 (38%), Gaps = 58/411 (14%)
Query: 244 VEEVVLEA-IGDRKG-------AGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRV 295
VEE++ E + D K A + EL +KE++ E E +AE E+
Sbjct: 453 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK--EAAEEKEEEPEAEEE-EVAAK 509
Query: 296 PEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEE 355
V+ ++P ++E EG++ + E +G EEG SE+
Sbjct: 510 KSPVKATAPEVKEEEGEKEEEEGQE--EEEEEDEGAKSDQAEEGG---------SEK--- 555
Query: 356 LLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKA----EESMGIGSEEKPG 411
EG E +E G E+ AEG + EE EK + EE + EKP
Sbjct: 556 ---EGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 611
Query: 412 TGRDEAEMSPVVER-KGGEKKLELESRG-SAEKLGTEREGGEEPLG---IERKVEGHLRA 466
+ SPV E+ K K +E +G S E G+ P+ +E K + +
Sbjct: 612 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 671
Query: 467 EKEGDEEKRGAEEEEVEEPLGVEKKG-GEEEPEATKEPLEAER-----------KGGEET 514
++ K + VEE + G GE++ E KE EA + K E
Sbjct: 672 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK 731
Query: 515 LEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEG 574
+AE EE++ T ++LE+ ++E + +E + E +E +G
Sbjct: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG 791
Query: 575 PQPQEKPVGALE-----EEGVKPQTAAEGQG---PLGDATPLLAETPAPEQ 617
+ K A+ +E V+ +T +G G G T L +PA E+
Sbjct: 792 AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEK 842
Score = 45.8 bits (107), Expect = 1e-04
Identities = 96/471 (20%), Positives = 167/471 (35%), Gaps = 104/471 (22%)
Query: 12 EVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQ 71
EV E+ +EE E E+E + ++ + + + E E + +
Sbjct: 519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 72 SPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAG 131
E + + ++ + + T + + + P + +G P+ +S VE
Sbjct: 579 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE-- 636
Query: 132 SVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPI 191
++ P P+SP E + G P P+ G S + P
Sbjct: 637 --------EKGKSPV------PKSPVEEK----GKSPVPKSPVEEKGKSPVSKSPVEEKA 678
Query: 192 PTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEA 251
+P S+ VG+ G E E +V+E E
Sbjct: 679 KSPVPKSPVEEAKSKAEVGK----------------------GEQKEEEEKEVKEAPKEE 716
Query: 252 IGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLE 311
++K ++P K + + E EA+ E+ + + V+ LE
Sbjct: 717 KVEKKEEKPKDVPEKKKAESPVKE-----------EAVAEVVTITKSVKV-------HLE 758
Query: 312 AAASIEGEDVPQGSPEGDGQGGSGG--EEGSFIWVERVTLSEEWEELLVEGLEGPEVAGR 369
EG+ + Q E + GG GG EEGS ++ E++ V G EV G+
Sbjct: 759 KETKEEGKPLQQ-EKEKEKAGGEGGSEEEGS----DKGAKGSRKEDIAVNG----EVEGK 809
Query: 370 ERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGE 429
E E E+ E+ G G EE+ G + ++SP E+KGG+
Sbjct: 810 E---------------------EVEQETKEK--GSGREEEKGVVTNGLDLSPADEKKGGD 846
Query: 430 KKLE-LESRGSAEKLGTEREGG-----EEPLGIERKVEGHLRAEKEGDEEK 474
K E + + EK+ +E G + + + +KVE H +E EEK
Sbjct: 847 KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH----EETFEEK 893
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/204 (27%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 382 AKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAE 441
A+ G GE+ E EK E E+K +D E E E+ + +
Sbjct: 694 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 753
Query: 442 KLGTEREGGEE--PLGIERKVE---GHLRAEKEG-DEEKRGAEEEEVEEPLGVEKKGGEE 495
K+ E+E EE PL E++ E G +E+EG D+ +G+ +E++ + E +G EE
Sbjct: 754 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI--AVNGEVEGKEE 811
Query: 496 EPEATKEPLEA--ERKG----GEETLEA-EKRGGEESLETEKTQGTEGDLNLEQGSREGS 548
+ TKE E KG G + A EK+GG++S E T + E G +G+
Sbjct: 812 VEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGG--DGA 869
Query: 549 ESQAEEMNEAGPPLEANTETRPEK 572
+ +E + ET EK
Sbjct: 870 TKYITKSVTVTQKVEEHEETFEEK 893
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 63.5 bits (153), Expect = 6e-10
Identities = 62/198 (31%), Positives = 90/198 (45%), Gaps = 26/198 (13%)
Query: 471 DEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAER-KGGEETLEAEKRGGEESLETE 529
+E+K AEE+E EEP + EEE A K P++A + EE E E+ G+E E E
Sbjct: 110 EEKKEAAEEKE-EEP-----EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE-EEE 162
Query: 530 KTQGTEGDLNLEQGS-REGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEE 588
+ +G + D E GS +EGS + E E G ET E EG + + K +EE+
Sbjct: 163 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG-------ETEAEAEGEEAEAKEEKKVEEK 215
Query: 589 GVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQP 648
+ T E P A++P P+ P E +G S P + P + P
Sbjct: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVE------EKGKSPVPKS---PVEEKGKSP 266
Query: 649 EPSAPTEGEEASGPKQKT 666
P +P E E+ P K+
Sbjct: 267 VPKSPVE-EKGKSPVPKS 283
Score = 59.3 bits (142), Expect = 1e-08
Identities = 66/241 (27%), Positives = 114/241 (47%), Gaps = 27/241 (11%)
Query: 392 EAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGE 451
E EK + EE++ +EE + ++E + + E K E + E E +A+K + E
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEA--AEEKEEEPEAE-EEEVAAKKSPVKATAPE 143
Query: 452 --EPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEP--LEAE 507
E G + + EG ++E +EE GA+ ++ EE G EK+G E+ E +E EAE
Sbjct: 144 VKEEEGEKEEEEG----QEEEEEEDEGAKSDQAEEG-GSEKEGSSEKEEGEQEEGETEAE 198
Query: 508 RKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGS---ESQAEEMNEAGPPLEA 564
+G E + EK+ E+S E + D +E+ + S +S EE ++ P
Sbjct: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP--- 255
Query: 565 NTETRPEKEGPQPQEKPVGALEEEGVKP----QTAAEGQGPLGDA-TPLLAETPAPEQPA 619
++ E++G P P +EE+G P +G+ P+ + A++P P+ P
Sbjct: 256 --KSPVEEKGKSP--VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 311
Query: 620 E 620
E
Sbjct: 312 E 312
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/204 (26%), Positives = 87/204 (42%), Gaps = 26/204 (12%)
Query: 472 EEKRGAEEEEVEEPLGVEKKGGEEE-------PEATKEPLEAERKGGEETLEAEKRGGEE 524
EEK+ A EE+ EEP E++ ++ PE +E E E + G+E E E G +
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
Query: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGA 584
E EG E+G +E E++AE G EA E + E++ + K
Sbjct: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAE---AEGEEAEAKEEKKVEEKSEEVATKEELV 226
Query: 585 LEEEGVKPQTAAE--GQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTY 642
+ + KP+ A + P+ + ++P P+ P E +G S P + P
Sbjct: 227 ADAKVEKPEKAKSPVPKSPVEEK----GKSPVPKSPVE------EKGKSPVPKS---PVE 273
Query: 643 APARQPEPSAPTEGEEASGPKQKT 666
+ P P +P E E+ P K+
Sbjct: 274 EKGKSPVPKSPVE-EKGKSPVSKS 296
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)
Query: 452 EPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEE---------PLGVEKKGGEEEPEATKE 502
E L + K E AE++ EE+ AEEEEV P E++G +EE E +E
Sbjct: 102 EELAVSMKEEKKEAAEEK--EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 159
Query: 503 PLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQA-------EEM 555
E E G ++ +AE+ G E+ +EK +G + + E EG E++A E+
Sbjct: 160 --EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE-AEAEGEEAEAKEEKKVEEKS 216
Query: 556 NEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKP----QTAAEGQGPLGDA-TPLLA 610
E E + + EK P +EE+G P +G+ P+ +
Sbjct: 217 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276
Query: 611 ETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTE 655
++P P+ P E +G+ P + P A+ P P +P E
Sbjct: 277 KSPVPKSPVE----EKGKSPVSKS-----PVEEKAKSPVPKSPVE 312
Score = 52.4 bits (124), Expect = 1e-06
Identities = 77/291 (26%), Positives = 112/291 (38%), Gaps = 67/291 (23%)
Query: 347 VTLSEEWEELLVEGLEGPEVAGRE-RGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIG 405
V++ EE +E E E PE E +SP+ A + E E E+ + EE
Sbjct: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE---- 161
Query: 406 SEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLR 465
EE G D+AE +GG +K GS+EK E+E GE E + EG
Sbjct: 162 -EEDEGAKSDQAE-------EGGSEK-----EGSSEKEEGEQEEGET----EAEAEGEEA 204
Query: 466 AEKEGDEEKRGAEEEEVEEPL-------------------GVEKKGGEEEPEA------- 499
KE + + +EE +E L VE+KG P++
Sbjct: 205 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGK 264
Query: 500 ---TKEPLEAERKGGEETLEAEKRGG--------EESLET--EKTQGTEGDLNLEQGSRE 546
K P+E + K E++G EE ++ K+ E E G E
Sbjct: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 324
Query: 547 GSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAE 597
E + +E+ EA P E E + EK P++K E VK + AE
Sbjct: 325 QKEEEEKEVKEA--PKEEKVEKKEEKPKDVPEKKKA----ESPVKEEAVAE 369
Score = 47.4 bits (111), Expect = 4e-05
Identities = 99/411 (24%), Positives = 160/411 (38%), Gaps = 58/411 (14%)
Query: 244 VEEVVLEA-IGDRKG-------AGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRV 295
VEE++ E + D K A + EL +KE++ E E +AE E+
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK--EAAEEKEEEPEAEEE-EVAAK 133
Query: 296 PEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEE 355
V+ ++P ++E EG++ + E +G EEG SE+
Sbjct: 134 KSPVKATAPEVKEEEGEKEEEEGQE--EEEEEDEGAKSDQAEEGG---------SEK--- 179
Query: 356 LLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKA----EESMGIGSEEKPG 411
EG E +E G E+ AEG + EE EK + EE + EKP
Sbjct: 180 ---EGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 412 TGRDEAEMSPVVER-KGGEKKLELESRG-SAEKLGTEREGGEEPLG---IERKVEGHLRA 466
+ SPV E+ K K +E +G S E G+ P+ +E K + +
Sbjct: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
Query: 467 EKEGDEEKRGAEEEEVEEPLGVEKKG-GEEEPEATKEPLEAER-----------KGGEET 514
++ K + VEE + G GE++ E KE EA + K E
Sbjct: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK 355
Query: 515 LEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEG 574
+AE EE++ T ++LE+ ++E + +E + E +E +G
Sbjct: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG 415
Query: 575 PQPQEKPVGALE-----EEGVKPQTAAEGQG---PLGDATPLLAETPAPEQ 617
+ K A+ +E V+ +T +G G G T L +PA E+
Sbjct: 416 AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEK 466
Score = 45.8 bits (107), Expect = 1e-04
Identities = 96/471 (20%), Positives = 167/471 (35%), Gaps = 104/471 (22%)
Query: 12 EVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQ 71
EV E+ +EE E E+E + ++ + + + E E + +
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
Query: 72 SPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAG 131
E + + ++ + + T + + + P + +G P+ +S VE
Sbjct: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE-- 260
Query: 132 SVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPI 191
++ P P+SP E + G P P+ G S + P
Sbjct: 261 --------EKGKSPV------PKSPVEEK----GKSPVPKSPVEEKGKSPVSKSPVEEKA 302
Query: 192 PTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEA 251
+P S+ VG+ G E E +V+E E
Sbjct: 303 KSPVPKSPVEEAKSKAEVGK----------------------GEQKEEEEKEVKEAPKEE 340
Query: 252 IGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLE 311
++K ++P K + + E EA+ E+ + + V+ LE
Sbjct: 341 KVEKKEEKPKDVPEKKKAESPVKE-----------EAVAEVVTITKSVKV-------HLE 382
Query: 312 AAASIEGEDVPQGSPEGDGQGGSGG--EEGSFIWVERVTLSEEWEELLVEGLEGPEVAGR 369
EG+ + Q E + GG GG EEGS ++ E++ V G EV G+
Sbjct: 383 KETKEEGKPLQQ-EKEKEKAGGEGGSEEEGS----DKGAKGSRKEDIAVNG----EVEGK 433
Query: 370 ERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGE 429
E E E+ E+ G G EE+ G + ++SP E+KGG+
Sbjct: 434 E---------------------EVEQETKEK--GSGREEEKGVVTNGLDLSPADEKKGGD 470
Query: 430 KKLE-LESRGSAEKLGTEREGG-----EEPLGIERKVEGHLRAEKEGDEEK 474
K E + + EK+ +E G + + + +KVE H +E EEK
Sbjct: 471 KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH----EETFEEK 517
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/204 (27%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 382 AKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAE 441
A+ G GE+ E EK E E+K +D E E E+ + +
Sbjct: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
Query: 442 KLGTEREGGEE--PLGIERKVE---GHLRAEKEG-DEEKRGAEEEEVEEPLGVEKKGGEE 495
K+ E+E EE PL E++ E G +E+EG D+ +G+ +E++ + E +G EE
Sbjct: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI--AVNGEVEGKEE 435
Query: 496 EPEATKEPLEA--ERKG----GEETLEA-EKRGGEESLETEKTQGTEGDLNLEQGSREGS 548
+ TKE E KG G + A EK+GG++S E T + E G +G+
Sbjct: 436 VEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGG--DGA 493
Query: 549 ESQAEEMNEAGPPLEANTETRPEK 572
+ +E + ET EK
Sbjct: 494 TKYITKSVTVTQKVEEHEETFEEK 517
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/335 (29%), Positives = 144/335 (42%), Gaps = 57/335 (17%)
Query: 345 ERVTLSEEWEELLVE-GLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMG 403
ER + W EL + + E A + R +E L A E+R EE+
Sbjct: 220 ERRRQEDYWRELEAKCKRQKAEAAEKRRLEEQRLQA-------------LERRLWEENRR 266
Query: 404 IGSEEKPGTGRD---EAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKV 460
E+ G G++ EAE +P R+ ++ LE AE+ E E R++
Sbjct: 267 QELLEEEGEGQEPPLEAERAP---REEQQRSLEAPGWEDAERREREERERLEAEEERRRL 323
Query: 461 EGHLRAEK----EGD---EEKRGAEEEE--VEEPLGVEKKGGEEEPEATK--EPLEAERK 509
+ +AE+ E D EE+R EEEE E L K+ EEE E + E EAE +
Sbjct: 324 QAQAQAEERRRLEEDARLEERRRQEEEEGRCAEEL---KRQEEEEAEGWEELEQQEAEVQ 380
Query: 510 GGEETLEAE---KRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANT 566
G E LE +RG EE E+ + EG +LE + SE +N+ LE
Sbjct: 381 GPPEALEETGEGRRGAEEEDLGEEEE--EGQAHLEDWRGQLSEL----LNDFEERLEDQE 434
Query: 567 ETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAE---CQP 623
+P EG + + G EE+ + + E QG GD A+ P PE+ E +P
Sbjct: 435 RLKP--EGQREHSEEPGICEEQNPEAERRREQQGRSGDFQG--ADRPGPEEKREEGDTEP 490
Query: 624 LLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEE 658
LL+ EGP +A P P + E +A +G +
Sbjct: 491 LLKQEGPV--EAAQP-----PVERKEAAALEQGRK 518
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/202 (28%), Positives = 80/202 (39%), Gaps = 21/202 (10%)
Query: 421 PVVERKGGEKKLELESRGS-AEKLGTEREGGEEPLGIE----------RKVEGHLRAEKE 469
P E+ G E + L+ G E T E PL E R++E + +K
Sbjct: 181 PQHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKA 240
Query: 470 GDEEKRGAEEEEV---EEPLGVEKKGGE---EEPEATKEPLEAERKGGEETLEAEKRGGE 523
EKR EE+ + E L E + E EE E + PLEAER EE + + G
Sbjct: 241 EAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGW 300
Query: 524 ESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVG 583
E E + + E E+ R +++QAEE R E+E + E+
Sbjct: 301 EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKR 360
Query: 584 ALEEEG----VKPQTAAEGQGP 601
EEE Q AE QGP
Sbjct: 361 QEEEEAEGWEELEQQEAEVQGP 382
Score = 38.5 bits (88), Expect = 0.020
Identities = 154/766 (20%), Positives = 251/766 (32%), Gaps = 171/766 (22%)
Query: 8 RQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTS 67
R+RLE E+RRLQ + +A R EE R+E +R+ E G A E+
Sbjct: 311 RERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEE-----GRCA-----EELKR 360
Query: 68 KDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSI 127
++ + EG + LE +Q + L+ G R+G + +
Sbjct: 361 QEEEEAEGWEE-----LEQQEAEVQGPPEALEETGEG------------RRGAE--EEDL 401
Query: 128 VEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPC 187
E GQ L + L+ E + R P + SE G C
Sbjct: 402 GEEEEEGQAHLEDWRGQLSELLNDFEERLEDQE----------RLKPEGQREHSEEPGIC 451
Query: 188 PSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEV 247
P E+ Q +GR G+ +G + E G T P L+ +
Sbjct: 452 EEQNPEAERRREQ-----QGRSGDFQGA-------DRPGPEEKREEGDTEPLLKQEGPVE 499
Query: 248 VLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGS---------DAEAMGEIGRVPEV 298
+ +RK A +LE + R + E+ W+ V + G+ P+V
Sbjct: 500 AAQPPVERKEAAALE------QGRKVEELRWQEVDERQTMPRPYTFQVSSGGKQILFPKV 553
Query: 299 -VQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWV-------ERVTLS 350
+ +P L AA + P+ SP S + I V V LS
Sbjct: 554 NLSPVTPAKDTGLTAAP--QEPKAPKASPVQHALPSSLSVPHTAILVTGAQLCGPAVNLS 611
Query: 351 EEWEELL--VEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEE 408
+ + + GLE + A G+ P G A+ G G+ E + ++ +
Sbjct: 612 QIKDTACKSLLGLEEKKHAEAPAGENPPRGPGDARAGSGKAKPRQESPSSASALAEWASI 671
Query: 409 KPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEK 468
+ ++ ER E RG + G +R+ P+ + + +
Sbjct: 672 RSRILKNAESDPRSSERDQLRPGDESTPRGRCDSRGNQRK--TPPVNAKFSIMPAWQKFS 729
Query: 469 EGDEE--KRGAEEEEVEE---------------PLGVEKKG-GEEEPEATKEPL------ 504
+G E K+ E E + + P GV + G G E+ E +EP
Sbjct: 730 DGGTETSKQSTEAESIRKRPMLGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGC 789
Query: 505 -------------------------------EAERKGGEETLEAEKRGGEESL------- 526
++E G + GGEE
Sbjct: 790 KFAKDLPSFLVPSLPYPPQKVVAHTEFTTSSDSETANGIAKPDPVMPGGEEKASPFGIKL 849
Query: 527 -ETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEG-------PQPQ 578
T + D EQ ++ S + +AGPP + E EG PQ
Sbjct: 850 RRTNYSLRFNCDQQAEQKKKKRHSSTGDSA-DAGPPAAGSARGEKEMEGVALKHGPSLPQ 908
Query: 579 E-KPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPE-------QPAECQPLLQGEGP 630
E K + + +P ++ P ++TPAPE P +P L +
Sbjct: 909 ERKQAPSTRRDSAEPSSSRSVPVAHPGPPPASSQTPAPEHDKAANKMPLAQKPALAPKPT 968
Query: 631 SANPSAHPVPTY------------APARQPEPSAPTEGEEASGPKQ 664
S P A P+ A PEPS P++ ++ S ++
Sbjct: 969 SQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRR 1014
Score = 33.5 bits (75), Expect = 0.66
Identities = 47/220 (21%), Positives = 84/220 (38%), Gaps = 38/220 (17%)
Query: 372 GDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKK 431
GD + G A + GE+ E K S+ ++ P T RD AE S +
Sbjct: 876 GDSADAGPPAAGSARGEKEMEGVALKHGPSLPQERKQAPSTRRDSAEPS-------SSRS 928
Query: 432 LELESRG----SAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLG 487
+ + G S++ E + + + +K A K + + ++ P
Sbjct: 929 VPVAHPGPPPASSQTPAPEHDKAANKMPLAQK---PALAPKPTSQTPPASPLSKLSRPYL 985
Query: 488 VE---KKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGS 544
VE ++ G +PE + EP + +++ + G EE +G
Sbjct: 986 VELLSRRAGRPDPEPS-EPSKEDQESSDRR-PPSPPGPEE----------------RKGQ 1027
Query: 545 REGSESQAEEMNEAGPPLEANTETRPEKEGPQP--QEKPV 582
+ E +A E A PPL A + +P + P+ +EKP+
Sbjct: 1028 KRDEEEEATERKPASPPLPATQQEKP-SQTPEAGRKEKPM 1066
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 62.8 bits (151), Expect = 1e-09
Identities = 83/322 (25%), Positives = 120/322 (37%), Gaps = 43/322 (13%)
Query: 362 EGPEVAGRERGDESPLG-AEGAKTGG-GEETWE--AEKRKAEESMGIGSEEKPGTGRDEA 417
EGP+ E D PL ++G + GG GE+ E + K + + + E+P T
Sbjct: 343 EGPQPRSVEPQDAGPLERSQGDEAGGHGEDRPEPLSPKESKKRKLELSRREQPPT----- 397
Query: 418 EMSPVVERKGGEKKLELE----SRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEE 473
E P + + L LE S+GS + GT+ GG++P + L A
Sbjct: 398 EPGPQSASEVEKIALNLEGCALSQGSL-RTGTQEVGGQDPGEAVQPCRQPLGARVADKVR 456
Query: 474 KRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQG 533
KR +E + V G + A K G + G EE
Sbjct: 457 KRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHS-----ENGVEED-------- 503
Query: 534 TEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQ 593
TEG ++G+ GS S+ + AGP + E+ E GP+P P G E
Sbjct: 504 TEGRTGPKEGT-PGSPSETPGPSPAGPAGDEPAESPSETPGPRPAG-PAGDEPAESPSET 561
Query: 594 TAAEGQGPLGDA---TPLLAETPAPEQPAECQPLLQGEGPSANPSAHPV------PTYAP 644
GP GD +P P+P P +P E PS P P P +P
Sbjct: 562 PGPRPAGPAGDEPAESPSETPGPSPAGPTRDEP---AESPSETPGPRPAGPAGDEPAESP 618
Query: 645 ARQP--EPSAPTEGEEASGPKQ 664
+ P P+ P E A P +
Sbjct: 619 SETPGPRPAGPAGDEPAESPSE 640
Score = 35.0 bits (79), Expect = 0.23
Identities = 32/112 (28%), Positives = 44/112 (39%), Gaps = 12/112 (10%)
Query: 99 QSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSE 158
Q+ + PSG P + GH S++ VE + G+T + P TP SP+
Sbjct: 477 QTLALAGSPAPSGHP---KAGH---SENGVEEDTEGRT--GPKEGTPGSPSETPGPSPAG 528
Query: 159 PREDVLGF----LPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSE 206
P D PGPR A + +E+ P P P G PSE
Sbjct: 529 PAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSE 580
Score = 30.8 bits (68), Expect = 4.3
Identities = 36/115 (31%), Positives = 40/115 (34%), Gaps = 17/115 (14%)
Query: 103 TGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPRED 162
TG + G PS G P + E R + PAG P ESPSE
Sbjct: 508 TGPKEGTPGSPS-ETPGPSPAGPAGDEPAESPSETPGPRPAGPAG--DEPAESPSET--- 561
Query: 163 VLGFLPGPRQVPGAAGDS-----SEANGPCPSPIPTPEQGLSQRAVPSEGRVGEA 212
PGPR G AGD SE GP P+ E S P G A
Sbjct: 562 -----PGPRPA-GPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPAGPA 610
Score = 30.0 bits (66), Expect = 7.3
Identities = 23/51 (45%), Positives = 25/51 (49%), Gaps = 11/51 (21%)
Query: 145 PAGLVGTPP-ESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTP 194
PAG G P ESPSE PGPR G AGD A P +P P+P
Sbjct: 606 PAGPAGDEPAESPSET--------PGPRPA-GPAGD-EPAESPSETPGPSP 646
Score = 29.6 bits (65), Expect = 9.5
Identities = 19/55 (34%), Positives = 22/55 (40%), Gaps = 8/55 (14%)
Query: 152 PPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSE 206
P ESPSE PGPR A + +E+ P P P G PSE
Sbjct: 594 PAESPSET--------PGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSE 640
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 61.6 bits (148), Expect = 2e-09
Identities = 84/314 (26%), Positives = 116/314 (36%), Gaps = 44/314 (14%)
Query: 376 PLGAEGAKTGGGEETWEAEKRKAEESMG----IGSEEKPGTGRDEAEMSPVVERKGGEKK 431
PL AEGA E + E EE++ + EE P E ++S +E E
Sbjct: 398 PLPAEGALE---EAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAP 454
Query: 432 LELES----RGSAEKLGTERE--GGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
E +S +AE+ E + EP E E +E E+ AE V+ P
Sbjct: 455 TEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAE---VQSP 511
Query: 486 LGVEKKGGEEEPE----------ATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTE 535
L E E E A + P EA+ EET E +S + E
Sbjct: 512 LAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEE 571
Query: 536 GDLNLEQGSREGSESQAEEMNEAGPPL---EANTETRPEKEGPQPQEKPVGALEEEGVKP 592
L L+ S G E+ AEE + A L EA+ E P + P P E+ ++ +
Sbjct: 572 APLELQPPS--GEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEE 629
Query: 593 QTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSA 652
A P +A + PA E PAE QP P A P QP P+
Sbjct: 630 APAEVQPPPAEEAPAEVQPPPAEEAPAEVQP----------PPAEEAPAEV---QPPPAE 676
Query: 653 PTEGEEASGPKQKT 666
E S P ++T
Sbjct: 677 EAPAEVQSLPAEET 690
Score = 51.6 bits (122), Expect = 2e-06
Identities = 148/648 (22%), Positives = 221/648 (34%), Gaps = 75/648 (11%)
Query: 35 KLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQ 94
+L+++R ++ S W M P + K+ Q+ +++ + + DS T
Sbjct: 125 QLKMDRSQQTSRTGYWTMMNI-----PPVEKVDKEQQTYFSESEIVVISRPDSSST---- 175
Query: 95 LQLLQSASTGAQHKPSGRP-SWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPP 153
+S +HK SG+ + +P + S E +GQ ++++ + G P
Sbjct: 176 ----KSKEDALKHKSSGKIFASEHPEFQPATNSNEE---IGQKNISRTSFTQETKKGPPV 228
Query: 154 ESPSEPREDVLGFLPGPRQVPGAAGD---SSEANGPCPSPIPTPEQG--LSQRAVPSEGR 208
E RE+V P G+A S+E P P Q + + +E R
Sbjct: 229 LLEDELREEVTV----PVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPR 284
Query: 209 VGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVK 268
E V E T D E KV+ E A +E PA ++
Sbjct: 285 PAEETHVQVQPSTEE----TPDAEAATAVAENSVKVQPPPAEE------APLVEFPAEIQ 334
Query: 269 ----EDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQG 324
E+ VE++ E + S E+ E P + +E I +
Sbjct: 335 PPSAEESPSVELLAEILPPSAEESPSE--EPPAEILPPPAEKSPSVELLGEIRSPSAQKA 392
Query: 325 SPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKT 384
E G E + VE T+ E + V+ L PE A RE E L +T
Sbjct: 393 PIEVQPLPAEGALEEAPAKVEPPTVEETLAD--VQPLL-PEEAPREEARELQLST-AMET 448
Query: 385 GGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLG 444
E E + +E+ +EE + A P + E + L SAE+
Sbjct: 449 PAEEAPTEFQSPLPKETT---AEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAH 505
Query: 445 TEREG--GEEPLGIERKVEGHLRA--EKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEAT 500
E + EE E E L A E DE A+ EE E + P A
Sbjct: 506 AEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAK 565
Query: 501 -----KEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEM 555
+ PLE + GEET E + L + E ++ E E+ AE
Sbjct: 566 GVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAE--EAPAEVQ 623
Query: 556 NEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAP 615
A + P +E P + P V+P A E A + PA
Sbjct: 624 PPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEE-------APAEVQPPPAE 676
Query: 616 EQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPK 663
E PAE Q L E P T A P P+ EEAS K
Sbjct: 677 EAPAEVQSLPAEETPIEE-------TLAAVHSP-PADDVPAEEASVDK 716
Score = 40.4 bits (93), Expect = 0.005
Identities = 59/249 (23%), Positives = 84/249 (33%), Gaps = 50/249 (20%)
Query: 460 VEGHLRAE------KEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEE 513
+E LR E +EG K+ A E +E E+ P + PL E E
Sbjct: 230 LEDELREEVTVPVVQEGSAVKKVASAE-------IEPPSTEKFPAKIQPPLVEEATAKAE 282
Query: 514 TLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEE-------------MNEAGP 560
AE+ + TE+T E + + S + AEE E P
Sbjct: 283 PRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESP 342
Query: 561 PLEANTETRPEKEGPQPQEKPVGAL----EEEGVKPQTAAEGQGPLGDATPL-------- 608
+E E P P E+P + E+ + E + P P+
Sbjct: 343 SVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAE 402
Query: 609 --LAETPAPEQP-------AECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEA 659
L E PA +P A+ QPLL E P A + P APTE +
Sbjct: 403 GALEEAPAKVEPPTVEETLADVQPLLPEEAP--REEARELQLSTAMETPAEEAPTEFQSP 460
Query: 660 SGPKQKTCQ 668
PK+ T +
Sbjct: 461 L-PKETTAE 468
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 60.8 bits (146), Expect = 4e-09
Identities = 63/213 (29%), Positives = 88/213 (41%), Gaps = 18/213 (8%)
Query: 444 GTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEP 503
GT GG L + V +++E +EE+ EEEE EE E++ EEE E +E
Sbjct: 864 GTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEE---EEEDFEEEEEDEEEY 920
Query: 504 LEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLE 563
E E + EE E + E E E+ + E + LE+ + E+ E PP
Sbjct: 921 FEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPP 980
Query: 564 ANTETRPEKEGP---QPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAE 620
P E P QP+ +P L E +P T E D P LA P Q
Sbjct: 981 TLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERG---ADTAPTLAPEALPSQG-- 1035
Query: 621 CQPLLQGEGPSANPSAHPVPTYAPARQPEPSAP 653
+ +GE P+A P + + EPSAP
Sbjct: 1036 -EVEREGESPAAGPPPQELV------EEEPSAP 1061
Score = 55.1 bits (131), Expect = 2e-07
Identities = 123/475 (25%), Positives = 160/475 (33%), Gaps = 71/475 (14%)
Query: 152 PPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGE 211
PPE+PS R PGP G S + GP PS P P G A P
Sbjct: 653 PPEAPSPFRAPPF-HPPGPMPSVG----SMPSAGPMPSAGPMPSAGPVPSARPGPPTTAN 707
Query: 212 AKG---GGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWV- 267
G G+VSV L E+ G+ + A D G + PA+V
Sbjct: 708 HLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVH 767
Query: 268 --KEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGS 325
KE+ VE+ E SD++ I VPE + P G P +
Sbjct: 768 YDKEEASDVEISLE----SDSDDSVVI--VPEGLPPLPP---------PPPSGATPPPIA 812
Query: 326 PEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEG-------LEGPEVAGRERGDESPLG 378
P G V EE EEL P V G L
Sbjct: 813 PTGPPTASPP-----------VPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLV 861
Query: 379 AEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRG 438
EG GGG E + + EE+ +E E E + E+ E E
Sbjct: 862 PEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEE-----EEEEEEEDFEEEEED 916
Query: 439 SAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPE 498
E E E EE + EG L E+E ++E+ E EEVE+ L GGE E
Sbjct: 917 EEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVED-LEFGTAGGEVEEG 975
Query: 499 ATKEPL----------------EAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQ 542
A P E E + G LE E+ G EE E+ T L E
Sbjct: 976 APPPPTLPPALPPPESPPKVQPEPEPEPG-LLLEVEEPGTEE----ERGADTAPTLAPEA 1030
Query: 543 GSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAE 597
+G + E AGPP + E P +E+ ++ P+T AE
Sbjct: 1031 LPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAE 1085
Score = 32.0 bits (71), Expect = 1.9
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 11/65 (16%)
Query: 601 PLGDATPLLAETPAPEQPAECQ--------PLLQ-GEGPSANP--SAHPVPTYAPARQPE 649
P+G P A P PE P+ + P+ G PSA P SA P+P+ P
Sbjct: 640 PMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSAR 699
Query: 650 PSAPT 654
P PT
Sbjct: 700 PGPPT 704
Score = 31.2 bits (69), Expect = 3.3
Identities = 31/115 (26%), Positives = 39/115 (33%), Gaps = 22/115 (19%)
Query: 553 EEMNEAGPPLEANTETR----PEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPL 608
EE ++ LE++++ PE P P P GA P+ P
Sbjct: 771 EEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPP-------------PIAPTGPP 817
Query: 609 LAETPAP--EQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASG 661
A P P E+P E L GP P P P P P P EG G
Sbjct: 818 TASPPVPAKEEPEE---LPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGG 869
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/253 (23%), Positives = 105/253 (41%), Gaps = 18/253 (7%)
Query: 299 VQTSSPRLQERLEAAASIEGEDVPQGSPEGD-GQGGSGGEEGSFIWVERVTLSEEWEELL 357
++T S ++E ++ +A E + E D + GE ++T + E+ +
Sbjct: 45 MKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEA-------KITEAPASEKEI 97
Query: 358 VEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEA 417
VE E E+G E E+ E E+ + EE G E+K G ++
Sbjct: 98 VEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDG 157
Query: 418 EMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGA 477
+ KG + K + + + + G +G E+ G + K E + +G E + G
Sbjct: 158 KEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEK--GEDEKEEEDRKETGDGKENEDGK 215
Query: 478 EEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGD 537
E+ + +E V+ K E+E E KE + G EE EK E L+ E+ E +
Sbjct: 216 EKGDKKEGKDVKVKEDEKEREDGKE----DEGGNEEEAGKEK----EDLKEEEEGKEEDE 267
Query: 538 LNLEQGSREGSES 550
+ + G +E +S
Sbjct: 268 IKEDDGKKEEPQS 280
Score = 47.4 bits (111), Expect = 4e-05
Identities = 48/181 (26%), Positives = 81/181 (44%), Gaps = 27/181 (14%)
Query: 426 KGGEKK--LELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVE 483
KGGEKK + E + E + E E G K + + E++G E+K G E+ E
Sbjct: 111 KGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDA 170
Query: 484 EPLGVEKKG---------GEEEPEATKEPLEAERKG-GEETLEAEKRGGEESLETEKTQG 533
+ KKG G+E+ E KE + + G G+E + +++G +K +G
Sbjct: 171 KEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKG-------DKKEG 223
Query: 534 TEGDLNLEQGSRE-GSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKP 592
+ + ++ RE G E + EAG E + + E+EG + E E++G K
Sbjct: 224 KDVKVKEDEKEREDGKEDEGGNEEEAGKEKE---DLKEEEEGKEEDE----IKEDDGKKE 276
Query: 593 Q 593
+
Sbjct: 277 E 277
Score = 47.0 bits (110), Expect = 6e-05
Identities = 55/231 (23%), Positives = 90/231 (38%), Gaps = 30/231 (12%)
Query: 388 EETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVER------KGGEKKLELESRGSAE 441
+ T + K K + M + + E + VVE K GE K+ E
Sbjct: 37 KRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKE 96
Query: 442 KLGTERE--------GGEEPLGIERKVEGHLRAEKEGDE---EKRGA----EEEEVEEPL 486
+ + E GGE+ + +V+ +KE +E E++G +++E E
Sbjct: 97 IVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEED 156
Query: 487 GVEKKGGEEEPEATKEPLEAER-KGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSR 545
G E K G E+ E KE + ++ + G+ E K GE+ E E + T E G
Sbjct: 157 GKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKE 216
Query: 546 EGSESQA--------EEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEE 588
+G + + E+ E G E E KE +E+ G E+E
Sbjct: 217 KGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDE 267
Score = 45.8 bits (107), Expect = 1e-04
Identities = 54/229 (23%), Positives = 89/229 (38%), Gaps = 31/229 (13%)
Query: 395 KRKAEESMGIGSEEKPGTGRDEAEMSPVV-----ERKGGEKKLELESRGSAEKLGT---- 445
KRKA + E K + R A + PV +R +K++ +S E + T
Sbjct: 3 KRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQA 62
Query: 446 ----------EREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEE 495
E + E E K+ +EKE E K EE +E+ +KGGE+
Sbjct: 63 VAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVK----EENIED---ATEKGGEK 115
Query: 496 EPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEM 555
+ E E E+ + + GE E + +G E + G+ +G +++ +E
Sbjct: 116 KEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKED 175
Query: 556 NEAGPPLEANTET-----RPEKEGPQPQEKPVGALEEEGVKPQTAAEGQ 599
+ G + N E EKE +E G E+G + EG+
Sbjct: 176 GKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGK 224
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 57.8 bits (138), Expect = 3e-08
Identities = 159/633 (25%), Positives = 244/633 (38%), Gaps = 75/633 (11%)
Query: 18 RRLQEEIRAARREVEEEKLRVERLKRKSLRE--RWLMDGAAAVPEPSEDPTSKDPQSPEG 75
R L +E + R +E+E R K +E + L + ++ P E K +S E
Sbjct: 690 RPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEE 749
Query: 76 QAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQ 135
Q Q +R LE T Q + L G Q + + RP + PL E + +
Sbjct: 750 QDQETLRTLEKE--TQQRRRSL------GEQDQMTLRPP-EKVDLEPLKSLDQE---IAR 797
Query: 136 TDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPE 195
N+ L E+ ++L L Q S E +P+ TPE
Sbjct: 798 PLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQ----APLWTPE 853
Query: 196 QGLSQRAV-PSEGRVGEAKGGGVVSVVWEGLRATED------CATGATGPELEAKVEEVV 248
+ ++Q A+ P E + E V V E R E+ + GA E EEV
Sbjct: 854 E-INQGAMNPLEKEIQEPLES--VEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVD 910
Query: 249 LEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQE 308
E+ + + +L + + R + E G + ++ R + V+ QE
Sbjct: 911 KESQRNLEEEENLGKGEYQESLRSLEEE------GQELPQSADVQRWEDTVEKDQELAQE 964
Query: 309 RLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAG 368
A +E ED + + + G +G EE VE+ L+ EE+ + G PE
Sbjct: 965 SPPGMAGVENEDEAELNLR-EQDGFTGKEEV----VEQGELNAT-EEVWIPGEGHPE--S 1016
Query: 369 RERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVE---R 425
E ++ L EGA GG E + + ++++ +G + P G EA + P+VE
Sbjct: 1017 PEPKEQRGL-VEGASVKGGAEGLQDPEGQSQQ-VGAPGLQAP-QGLPEA-IEPLVEDDVA 1072
Query: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKV-----EGHLRAEK--EGDEEKRGAE 478
GG++ GS +G E G EP G + V GHL E+ E E+ E
Sbjct: 1073 PGGDQASPEVMLGSEPAMG-ESAAGAEP-GPGQGVGGLGDPGHLTREEVMEPPLEEESLE 1130
Query: 479 EEEVEEPLG----VEKKGG-----EEEPEATKEPLEAERKGGEETLEAEKRGGEESL--E 527
+ V+ G +E+ GG E P +++P E R+G EE+ RG EE+ E
Sbjct: 1131 AKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAE 1190
Query: 528 TEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEE 587
T G++ GS E E + P E P GPQPQ + +E
Sbjct: 1191 TLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAP---GPQPQAE---GSQE 1244
Query: 588 EGVKPQTAAEGQGPLGDATPLLAETPAPEQPAE 620
Q AE G + L PE P E
Sbjct: 1245 ASWGVQGRAEALGKVESEQEELGSGEIPEGPQE 1277
Score = 54.7 bits (130), Expect = 3e-07
Identities = 129/588 (21%), Positives = 214/588 (36%), Gaps = 115/588 (19%)
Query: 56 AAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSW 115
A P + P PQ+P A IR + L LQ+Q
Sbjct: 380 ARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQ-------------------GG 420
Query: 116 RRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPG 175
R+Q PL R ++PA ++ P E PG ++
Sbjct: 421 RKQAPEPLR-------------AEARVAIPASVLPGPEE-------------PGGQRQEA 454
Query: 176 AAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSV--------VWEGLRA 227
+ G S E + P+ L E + GE+ G V S+ +W GL
Sbjct: 455 STGQSPEDHASLAPPLSPDHSSL-------EAKDGESGGSRVFSICRGEGEGQIW-GLVE 506
Query: 228 TEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAE 287
E G L+ ++ E E +RK ++P + + + E + E + + +
Sbjct: 507 KETAIEGKVVSSLQQEIWE---EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQ 563
Query: 288 AMGEIGRVPEVVQTSSPRLQERLEAAASIEGE------DVPQGSP---EGDGQGGSGGEE 338
+ + R + S L+E LE S+E E DV P E GQ G+E
Sbjct: 564 SHETLERENQECPRS---LEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKE 620
Query: 339 GSFIWVE--------RVTLSEEWEELLVEGLEGPEVAGR--------------------- 369
+ +L E L G E E+
Sbjct: 621 DTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRS 680
Query: 370 -ERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEE--KPGTGRDEAEMSPV-VER 425
E GDE L + + E E ++A S+ ++E K D++ + P+ E
Sbjct: 681 PEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETEN 740
Query: 426 KGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
+ LE + + + L E + LG + ++ LR ++ D E + ++E+ P
Sbjct: 741 HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMT--LRPPEKVDLEPLKSLDQEIARP 798
Query: 486 LGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSR 545
L E + E +E +EA + E LE+ K G+E+LET K+ T+ L +
Sbjct: 799 L--ENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEIN 856
Query: 546 EGSESQAE-EMNEAGPPLEANTET-RPEKEGPQPQEKPVGALEEEGVK 591
+G+ + E E+ E +E N ET R +E Q + +GA E ++
Sbjct: 857 QGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLR 904
Score = 50.1 bits (118), Expect = 7e-06
Identities = 107/472 (22%), Positives = 185/472 (39%), Gaps = 51/472 (10%)
Query: 188 PSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEV 247
P+ +P+P + VP+ + E ++ + T + A E+ A+ +
Sbjct: 353 PTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPL 412
Query: 248 -VLEAIGDRKGAGS-LELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPR 305
+L+ G RK A L A V ++ E GG EA G+ PE + +P
Sbjct: 413 SLLQTQGGRKQAPEPLRAEARVAIPASVLPGP-EEPGGQRQEA--STGQSPEDHASLAPP 469
Query: 306 LQERLEAAASIEGEDVPQGSPE------GDGQGGSGGEEGSFIWVERVTLS----EEWEE 355
L +S+E +D G G+G+G G +E +S E WEE
Sbjct: 470 LSPD---HSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEE 526
Query: 356 LLVEGLEGPEVAGRERGDESPLGAEGAKTGGGE--ETWEAEKRKAEESMGIGSEEKPGTG 413
E L E+ + + PL E K+ G E E+ + + ++ E++ ++E P +
Sbjct: 527 ---EDLNRKEI----QDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSL 579
Query: 414 RDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIE--------RKVEGHLR 465
++ E +E++ E ++E EK E G +P G E +K L
Sbjct: 580 EEDLETLKSLEKENKELLKDVEVVRPLEK---EAVGQLKPTGKEDTQTLQSLQKENQELM 636
Query: 466 AEKEGDEEK---RGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGG 522
EG+ E G E +E+ L + + +EPL + G EE L +
Sbjct: 637 KSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKEN 696
Query: 523 EESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPV 582
+E L + + + E +LE+ ++E ++ EE PLE Q QE +
Sbjct: 697 QEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQE-TL 755
Query: 583 GALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANP 634
LE+E + + LG+ + T P + + +PL + A P
Sbjct: 756 RTLEKE------TQQRRRSLGEQDQM---TLRPPEKVDLEPLKSLDQEIARP 798
Score = 50.1 bits (118), Expect = 7e-06
Identities = 146/642 (22%), Positives = 224/642 (34%), Gaps = 129/642 (20%)
Query: 92 QSQLQLLQSASTGAQHKPSGRPSWRRQGHR-PLSQSIVEAGSVGQTDLNKRASLPAGLVG 150
+SQ L + + G S +G P S + + D P G+ G
Sbjct: 912 ESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAG 971
Query: 151 TPPESPSEPREDVLGFLPGPRQV--PGAAGDSSEA----NGPCPSPIPTPEQGLSQRAVP 204
E +E G +V G + E G SP P ++GL + A
Sbjct: 972 VENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGA-- 1029
Query: 205 SEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAK------VEEVVLEAIGDRKGA 258
KGG EGL+ E + P L+A +E +V + +
Sbjct: 1030 ------SVKGGA------EGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQ 1077
Query: 259 GSLEL-----PAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAA 313
S E+ PA + G +GVGG +G+ G + P +E LEA
Sbjct: 1078 ASPEVMLGSEPAMGESAAGAEPGPGQGVGG-----LGDPGHLTREEVMEPPLEEESLEAK 1132
Query: 314 ASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGD 373
++G + P+ E GG G E R + WE P GRE +
Sbjct: 1133 R-VQGLEGPRKDLEE--AGGLGTEFSELPGKSR----DPWE---------PPREGREESE 1176
Query: 374 -ESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEK-----PGTGRDEAEMSPVVE--- 424
E+P GAE A ET A +GSEE P +P++E
Sbjct: 1177 AEAPRGAEEAFPA---ETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAP 1233
Query: 425 ----RKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEE 480
+ G ++ +G AE LG + E +E LG EG ++EG+E + +EE+
Sbjct: 1234 GPQPQAEGSQEASWGVQGRAEALG-KVESEQEELGSGEIPEG---PQEEGEESREESEED 1289
Query: 481 EVEE------PLGVEKKG---------GEEEPEA--------------TKEPLEAERKGG 511
E+ E PLG + GE+ P E LEA
Sbjct: 1290 ELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEK 1349
Query: 512 EETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPL--------- 562
EE E E+ G +S +E+ + DL E G + E P L
Sbjct: 1350 EEGEEGEEECGRDSDLSEEFE----DLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDR 1405
Query: 563 --EANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAE 620
E++ E+ G + +E +EEG +P G G + L+ + E
Sbjct: 1406 DGESDGFADEEESGEEGEED-----QEEGREPGAGRWGPGSSVGSLQALSSSQRGE---- 1456
Query: 621 CQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGP 662
L+ + S + A A P+ + TE ++++ P
Sbjct: 1457 ---FLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEP 1495
Score = 39.3 bits (90), Expect = 0.012
Identities = 88/387 (22%), Positives = 141/387 (36%), Gaps = 68/387 (17%)
Query: 59 PEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQ 118
P P+ P +D P+ QA+ +++ + +Q + + L + + SG Q
Sbjct: 1221 PSPTYTPILEDAPGPQPQAEGS----QEASWGVQGRAEALGKVESEQEELGSGEIPEGPQ 1276
Query: 119 GHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAG 178
S+ E +G+T + S P G SP+ PR D G Q P G
Sbjct: 1277 EEGEESREESEEDELGETLPD---STPLGFY---LRSPTSPRWDPTG-----EQRPPPQG 1325
Query: 179 DSSEANGPCPSPIPTPEQGLSQRAVPSE---GRVGEAKGG--GVVSVVWEGLRATEDCAT 233
++ + P +GL A PSE G GE + G +S +E L
Sbjct: 1326 ETGKEGW---DPAVLASEGLE--APPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLP 1380
Query: 234 GATGPELE--AKVEEVVLE-AIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMG 290
G G E +V +++L+ A DR G E G +D E G
Sbjct: 1381 GVPGEVAEPLGQVPQLLLDPAAWDRDG---------------------ESDGFADEEESG 1419
Query: 291 EIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLS 350
E G + +E E A G GS G Q S + G F+ + V++S
Sbjct: 1420 EEGEEDQ---------EEGREPGAGRWGP----GSSVGSLQALSSSQRGEFLESDSVSVS 1466
Query: 351 EEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKP 410
W++ L + G E + + A+ G EE + + E+ + G E P
Sbjct: 1467 VPWDDSLRGAVAGAPKTALETESQ-----DSAEPSGSEEESDPVSLEREDKVP-GPLEIP 1520
Query: 411 GTGRDEAEMSPVVERKGGEKKLELESR 437
D + ++ G LE +S+
Sbjct: 1521 SGMEDAGPGADIIGVNGQGPNLEGKSQ 1547
Score = 35.0 bits (79), Expect = 0.23
Identities = 50/221 (22%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 416 EAEMSPVVERKGGEKKLELESRGSAEKLGTERE---GGEEPLGIERKVEGHLRAEKEGDE 472
E E+ ++ G E L+S + L T E G PL E++++ L + + E
Sbjct: 822 ETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPL--EKEIQEPLESVEVNQE 879
Query: 473 EKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGG---EESLETE 529
R EEE E + G E + P E +++ E E G +ESL +
Sbjct: 880 TFRLLEEENQESLRSL----GAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSL 935
Query: 530 KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEG 589
+ +G E + + E + + +E+ + PP A E E E + E++G
Sbjct: 936 EEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAE--------LNLREQDG 987
Query: 590 VKPQTAAEGQGPLGDATPLLAE---TPAPEQPAECQPLLQG 627
+ QG L + P +P E + L++G
Sbjct: 988 FTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEG 1028
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 57.8 bits (138), Expect = 3e-08
Identities = 66/207 (31%), Positives = 85/207 (41%), Gaps = 29/207 (14%)
Query: 369 RERGDESPLGAEGAKTGGGE---ETWEAEKRKAEESMGI----GSEEKPGTG----RDEA 417
RER E EG K E E E EKRK E G +EK G R+
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 418 EMSPVVERKGGE-----KKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDE 472
+ E K GE KK E + RG K G ERE EE ERK + E+E +
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKER 158
Query: 473 EKR----------GAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGG 522
E++ G +EEE +E E+K E + K+ E ERK E + K+
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK--ERERKERRERKKERKKKE 216
Query: 523 EESLETEKTQGTEGDLNLEQGSREGSE 549
E E +K + T E+G RE E
Sbjct: 217 ERKKERQKDRQTNW-REKERGKRERKE 242
Score = 52.4 bits (124), Expect = 1e-06
Identities = 44/147 (29%), Positives = 68/147 (46%), Gaps = 4/147 (2%)
Query: 444 GTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEP 503
G + E E IE + EG E E +E+R E+ + E +++ G++E + ++
Sbjct: 33 GWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKK 92
Query: 504 LEAERKGGEETLEAEKRGGEESLETEKTQGTE-GDLNLEQGSREGSES-QAEEMNEAGPP 561
E ERK + E E + GEE + +K + E G + E RE E + EE E
Sbjct: 93 EERERK--KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 562 LEANTETRPEKEGPQPQEKPVGALEEE 588
E + R KE + + K VG EEE
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEE 177
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/196 (27%), Positives = 82/196 (41%), Gaps = 33/196 (16%)
Query: 391 WEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEK-KLELESRGSAEKLGTEREG 449
W++E R+ E + E G+ E E ER+ EK K E E E+ E++G
Sbjct: 34 WQSEIREREREIETRKE-----GKKERESERKKERREREKRKREREKERKRERGKKEKKG 88
Query: 450 GEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPE---ATKEPLEA 506
ERK KE E K+ E+E +E EK+ +E+ E +KE E
Sbjct: 89 -------ERK--------KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 507 ERK---GGEETLEAEKRGGEESLETEKTQGTE------GDLNLEQGSREGSESQAEEMNE 557
ERK EE E E++ E E E+ + + G+ E+ +E E + E N
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 558 AGPPLEANTETRPEKE 573
E + R E++
Sbjct: 194 KERKKERERKERRERK 209
Score = 38.5 bits (88), Expect = 0.020
Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 2/143 (1%)
Query: 359 EGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAE 418
E EG E R++ ++ G +K G E E KR+ + EE+ R+ E
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRT-SKEGKERERKEERKREERKERERKKEEREKE-RERKE 162
Query: 419 MSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAE 478
++ GEK+ E + + E+ ER E ERK + E++ EE++
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKER 222
Query: 479 EEEVEEPLGVEKKGGEEEPEATK 501
+++ + +++G E E K
Sbjct: 223 QKDRQTNWREKERGKRERKERKK 245
Score = 30.8 bits (68), Expect = 4.3
Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 9/108 (8%)
Query: 492 GGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQ 551
G + E + +E RK G++ E+E++ E K + E + E+G +E +
Sbjct: 33 GWQSEIREREREIET-RKEGKKERESERKKERREREKRKRE-REKERKRERGKKEKKGER 90
Query: 552 AEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQ 599
+E E + R EKE + +EK +E+ + +T+ EG+
Sbjct: 91 KKEERE-------RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 57.4 bits (137), Expect = 4e-08
Identities = 79/302 (26%), Positives = 121/302 (40%), Gaps = 33/302 (10%)
Query: 367 AGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERK 426
+G E ++ L E T EE E E+ + ++ ++ ++ +S E+
Sbjct: 1031 SGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKD 1090
Query: 427 GGEK-KLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEP 485
G+ + E S +++ T E E E + E +EE EEEE EE
Sbjct: 1091 EGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESS-PSSSEDEEEVVAREEEEEEE- 1148
Query: 486 LGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSR 545
E++ EE A+ P + E+ G E L A +SL E+ E D+ E +
Sbjct: 1149 ---EEEMVAEESMASAGPEDFEQDGEEAAL-APGAPAVDSLGMEE----EVDIETEAVAP 1200
Query: 546 EGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEG---VKPQTAAEGQGPL 602
E S +E PPL E + +P E+P L +EG + P+ A+
Sbjct: 1201 EERPSMLDE-----PPLPVGVEEPADSR--EPPEEP--GLSQEGAMLLSPEPPAKEV--- 1248
Query: 603 GDATPLLAETPAPEQPAECQPLLQGEGPSANPSA--HPVPTYAPARQPEPSAPTEGEEAS 660
+A P L+ APE E +P E P P P+P P R P P E +AS
Sbjct: 1249 -EARPPLSPERAPEHDLEVEP----EPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDAS 1303
Query: 661 GP 662
P
Sbjct: 1304 HP 1305
Score = 40.8 bits (94), Expect = 0.004
Identities = 78/337 (23%), Positives = 128/337 (37%), Gaps = 69/337 (20%)
Query: 389 ETWEAEKRKAEESMGIGSEEKPG----TGRDEAEMSPVVERKGGEKKLELESRGSAEKLG 444
E+W + E +G+G + + + + + P G +K+L + E
Sbjct: 934 ESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEE 993
Query: 445 TEREGGEE----PLGIER---KVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEP 497
+ERE + P + + K G R E G EE+E +E L E++ EEE
Sbjct: 994 SERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDE-KESLSEEQESTEEEE 1052
Query: 498 EATKEPLEAERKGGE-ETLEAEKRGGEESLETEKTQGTEGDLNLEQ------------GS 544
EA +E E + + + + + E++ +E ++ EGD + E+ S
Sbjct: 1053 EAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSS 1112
Query: 545 REGSESQAEEMNEAGPPLEANTE----TRPEKE----------------GPQPQEKP--- 581
E SES E + P + E R E+E GP+ E+
Sbjct: 1113 SESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEE 1172
Query: 582 ------VGALEEEGVKPQTAAEGQGPLGDATP-LLAETPAP---EQPAEC-----QPLLQ 626
A++ G++ + E + + P +L E P P E+PA+ +P L
Sbjct: 1173 AALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLS 1232
Query: 627 GEGP---SANPSAHPV---PTYAPARQPEPSAPTEGE 657
EG S P A V P +P R PE E E
Sbjct: 1233 QEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPE 1269
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 57.0 bits (136), Expect = 6e-08
Identities = 69/286 (24%), Positives = 117/286 (40%), Gaps = 44/286 (15%)
Query: 380 EGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGS 439
EG + E+ + E R +SM E++ R+E + + E K +++ ELE G+
Sbjct: 268 EGRRIEFAEQINKMEARPRRQSM---KEKEHQVVRNEEQKAEQEEGKVAQREEELEETGN 324
Query: 440 AEKLGTEREGGEEPLGIERKVE-GHLRAEKEGDEEKRGAEEE---EVEEPLGVEKKGGEE 495
E GEE E+++ H AEKE +EE++ E E E E + +K +
Sbjct: 325 QHNDVEIEEAGEEE---EKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDS 381
Query: 496 EPEATKEPLEAERK-----GGEETLEAEKRGGEESLETEKTQGTEGDLNLE-QGSREGSE 549
+PE + LE +E +E + E E E ++ E ++ E + +E
Sbjct: 382 QPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKS 441
Query: 550 SQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLL 609
+ N + +E +E + EKE +PQ +PV +PQ ++
Sbjct: 442 LSPGKENVSALDMEKESEEKEEKES-EPQPEPVA-------QPQPQSQ------------ 481
Query: 610 AETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTE 655
P + ++ QP+LQ + PS P QP P E
Sbjct: 482 ---PQLQLQSQSQPVLQSQPPS-----QPEDLSLAVLQPTPQVTQE 519
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
Length = 2524
Score = 56.6 bits (135), Expect = 7e-08
Identities = 99/391 (25%), Positives = 139/391 (35%), Gaps = 63/391 (16%)
Query: 300 QTSSPRLQERLEAAASIEGEDVPQGSPEG-DGQGGSGGEEGSFIWVERVTLSEEWEELLV 358
+ ++ R +++ AAAS E P E + G SG EE + EE E L
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEE---------EMVEEAEALHA 726
Query: 359 EGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGT-GRD-- 415
G E P RG+ S G E+ + +A + G + P T G D
Sbjct: 727 SGNEVP------RGECS--GPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGP 778
Query: 416 --------------EAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVE 461
E +P E G SA +E EE VE
Sbjct: 779 PPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVE 838
Query: 462 GHLRAEKEGDEEKRGAEEE------EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETL 515
EG+E+K A EE + EEP+ E EE A + EA E L
Sbjct: 839 -------EGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGAL 891
Query: 516 EAEKR-GGEESLETEKTQGT--EGDLNLEQGSREGSESQAEEMNE-AGPPLEANTETRPE 571
+AEK+ GG T K+ G + D + + E E++ + N P T T
Sbjct: 892 KAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDP 951
Query: 572 KEGPQPQEKPVGALE----EEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQG 627
+ PQ KP+ + + P + P DA P PAP P QP +
Sbjct: 952 RANASPQ-KPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQP--ES 1008
Query: 628 EGPSANPSAHPVPTYAPARQPEPSAPTEGEE 658
+ P P + P +R P P A E E+
Sbjct: 1009 DAPQ-QPGSSP---RGKSRSPAPPADKEAEK 1035
Score = 38.9 bits (89), Expect = 0.016
Identities = 73/325 (22%), Positives = 120/325 (36%), Gaps = 62/325 (19%)
Query: 345 ERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGI 404
E+ + + E+LL E + + +G + ++ + ++G KT + +RK + +
Sbjct: 534 EKPEVENDKEDLLKEKTD--DTSGEDNDEKEAVASKGRKTANSQG-----RRKGRITRSM 586
Query: 405 GSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREG----GEEPLGIERKV 460
+E E ++P + +L SR + E++ T ++G G I R V
Sbjct: 587 ANE-----ANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMV 641
Query: 461 EGHLRAEKEG---DEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEA 517
++ + + +KR + ++E L K E+E A ++ +A EE
Sbjct: 642 GSKTVSQCKNFYFNYKKR----QNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFP 697
Query: 518 EKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQP 577
EE +E G E EEM E L A+ P E P
Sbjct: 698 PVVEDEE-MEASGVSGNE-----------------EEMVEEAEALHASGNEVPRGECSGP 739
Query: 578 QEKPVGALEEEGVKPQT-AAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSA 636
+ E P T AA+ G G P+ PA L +GP P
Sbjct: 740 ATVNNSSDTESIPSPHTEAAKDTGQNG-----------PKPPAT----LGADGPPPGP-- 782
Query: 637 HPVPTYAPARQPEPSAPTEGEEASG 661
PT P P P+ PT EA+G
Sbjct: 783 ---PTPPPEDIPAPTEPTPASEATG 804
Score = 33.9 bits (76), Expect = 0.50
Identities = 34/133 (25%), Positives = 63/133 (47%), Gaps = 18/133 (13%)
Query: 465 RAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEE 524
R K ++++ ++++ ++ + + EE+ E KE EAE++ + +E +K E
Sbjct: 489 RRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK-EAEKEEEKPEVENDK----E 543
Query: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGA 584
L EKT T G+ N E +E S+ + AN++ R ++G + A
Sbjct: 544 DLLKEKTDDTSGEDNDE---KEAVASKGRK--------TANSQGR--RKGRITRSMANEA 590
Query: 585 LEEEGVKPQTAAE 597
EE + PQ +AE
Sbjct: 591 NSEEAITPQQSAE 603
Score = 30.8 bits (68), Expect = 4.3
Identities = 29/83 (34%), Positives = 34/83 (40%), Gaps = 12/83 (14%)
Query: 130 AGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANG-PCP 188
A GQ A+L G G PP P+ P ED+ P P + A SEA G P P
Sbjct: 759 AKDTGQNGPKPPATL--GADGPPPGPPTPPPEDI----PAPTEPTPA----SEATGAPTP 808
Query: 189 SPIPTPEQGLSQRAVPSEGRVGE 211
P P P VP E + E
Sbjct: 809 PPAP-PSPSAPPPVVPKEEKEEE 830
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/384 (23%), Positives = 143/384 (37%), Gaps = 66/384 (17%)
Query: 327 EGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEG----------PEVAG-----RER 371
EG G G E+ V+ ++S+E E L EG E PE A +
Sbjct: 85 EGYGVDSDGSEDTE---VKDASVSDESEGTL-EGAEAETSGQDEIHRPETAEGRSPVKSH 140
Query: 372 GDESPLGAEGAKTGGGEETWE-------------AEKRKAEESMGIGSEEKPGTGRDEAE 418
+P+G+ A + G +++ AE+ EE +G ++ PG E
Sbjct: 141 FGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQE 200
Query: 419 MSPVVERKGGEKKLELESRGSAE--KLGTEREGGEEPLGIE-------RKVEGHLRAEKE 469
+ + GEK L ++ + E ++ TER P +E K +G L E+E
Sbjct: 201 AAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEE 260
Query: 470 GDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETE 529
+EE+ EEEE + E++ EEE E +E E E + EE E E+ + + E
Sbjct: 261 DEEEEEEEEEEEED-----EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315
Query: 530 KTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEG 589
T T +++ E + E P E R + + + + +E
Sbjct: 316 DTSHT--------SAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDES 367
Query: 590 VKPQTAAEGQ-GPLGDATPLLAETPAPEQPAECQPLLQGEGPSANP--SAHPVPTY---- 642
G G L A L AE C P Q + P +A P+ T
Sbjct: 368 EMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSY 427
Query: 643 -----APARQPEPSAPTEGEEASG 661
+ A + E PT G + +G
Sbjct: 428 YSKDPSRAEKREIKCPTPGCDGTG 451
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
Length = 2462
Score = 55.5 bits (132), Expect = 2e-07
Identities = 95/385 (24%), Positives = 135/385 (35%), Gaps = 67/385 (17%)
Query: 300 QTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVE 359
+ ++ R +++ AAAS E P E G G E + T++ + E
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSD---TE 732
Query: 360 GLEGPEV-AGRERGDESP-----LGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTG 413
+ P A ++ G P LGA+G G E+ P
Sbjct: 733 SIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPP---------------PEDIPAP- 776
Query: 414 RDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEE 473
E +P E G SA +E EE VE EG+E+
Sbjct: 777 ---TEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVE-------EGEEQ 826
Query: 474 KRGAEEE------EVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKR-GGEESL 526
K A EE + EEP+ E EE A + EA E L+AEK+ GG
Sbjct: 827 KPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRA 886
Query: 527 ETEKTQGTEGDLNLEQGSREGSESQAEEMNEA-GPPLEANTETRPE----KEGPQPQEKP 581
T K+ G Q S + A+E++EA G RP P+ P
Sbjct: 887 TTAKSSGA------PQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASP 940
Query: 582 VGALEEEGVKPQTAA--------EGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSAN 633
L+ + +K + AA + P DA P PAP P QP + + P
Sbjct: 941 QKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQP--ESDAPQ-Q 997
Query: 634 PSAHPVPTYAPARQPEPSAPTEGEE 658
P + P +R P P A E E+
Sbjct: 998 PGSSP---RGKSRSPAPPADKEAEK 1019
Score = 37.0 bits (84), Expect = 0.059
Identities = 71/294 (24%), Positives = 112/294 (38%), Gaps = 44/294 (14%)
Query: 388 EETWEAEKRKAEESMGIGSEEKPGTGRDEAEM-SPVVERKGGEKKLELESRGSAEKLGTE 446
EE E EK K E EEKP D+ ++ + GE E E+ S + T
Sbjct: 518 EEKDEKEKEKEAEK----EEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRK-TA 572
Query: 447 REGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPL-- 504
G I R + +E E ++ AE +E L + EEE E K+ L
Sbjct: 573 NSQGRRKGRITRSMANEANSE-EAITPQQSAELASME--LNESSRWTEEEMETAKKGLLE 629
Query: 505 ------EAERKGGEETLEA---------EKRGGEESLETEKTQGTEGDLNLEQGSREGSE 549
R G +T+ +++ +E L+ K + E + N + ++
Sbjct: 630 HGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLK-MEKERNARRKKKKAPA 688
Query: 550 SQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLL 609
+ +EE A PP+ + E E G E+ + +EE +++ + T
Sbjct: 689 AASEEA--AFPPVVEDEEM--EASGVSGNEEEM--VEEAEATVNNSSDTESIPSPHTEAA 742
Query: 610 AETP--APEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASG 661
+T P+ PA L +GP P PT P P P+ PT EA+G
Sbjct: 743 KDTGQNGPKPPAT----LGADGPPPGP-----PTPPPEDIPAPTEPTPASEATG 787
Score = 33.9 bits (76), Expect = 0.50
Identities = 34/133 (25%), Positives = 63/133 (47%), Gaps = 18/133 (13%)
Query: 465 RAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEE 524
R K ++++ ++++ ++ + + EE+ E KE EAE++ + +E +K E
Sbjct: 489 RRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK-EAEKEEEKPEVENDK----E 543
Query: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGA 584
L EKT T G+ N E +E S+ + AN++ R ++G + A
Sbjct: 544 DLLKEKTDDTSGEDNDE---KEAVASKGRK--------TANSQGR--RKGRITRSMANEA 590
Query: 585 LEEEGVKPQTAAE 597
EE + PQ +AE
Sbjct: 591 NSEEAITPQQSAE 603
Score = 30.8 bits (68), Expect = 4.3
Identities = 29/83 (34%), Positives = 34/83 (40%), Gaps = 12/83 (14%)
Query: 130 AGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANG-PCP 188
A GQ A+L G G PP P+ P ED+ P P + A SEA G P P
Sbjct: 742 AKDTGQNGPKPPATL--GADGPPPGPPTPPPEDI----PAPTEPTPA----SEATGAPTP 791
Query: 189 SPIPTPEQGLSQRAVPSEGRVGE 211
P P P VP E + E
Sbjct: 792 PPAP-PSPSAPPPVVPKEEKEEE 813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.127 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,522,934
Number of Sequences: 37866
Number of extensions: 2206728
Number of successful extensions: 22455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 348
Number of HSP's successfully gapped in prelim test: 1557
Number of HSP's that attempted gapping in prelim test: 11163
Number of HSP's gapped (non-prelim): 8190
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.