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Search of human proteins with 222446611
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222446611 R-spondin family, member 2 [Homo sapiens]
(243 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222446611 R-spondin family, member 2 [Homo sapiens] 536 e-153
gi|18490982 R-spondin 3 [Homo sapiens] 228 3e-60
gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo... 210 1e-54
gi|84490388 R-spondin1 [Homo sapiens] 208 3e-54
gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo... 146 2e-35
gi|108773804 Fraser syndrome 1 [Homo sapiens] 55 4e-08
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 55 6e-08
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 53 3e-07
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 53 3e-07
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 53 3e-07
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 53 3e-07
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 52 4e-07
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 52 4e-07
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 52 4e-07
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 46 3e-05
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 43 3e-04
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 43 3e-04
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 41 8e-04
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 41 8e-04
gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens] 40 0.001
gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens] 40 0.001
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 40 0.002
gi|110347437 latent transforming growth factor beta binding prot... 39 0.003
gi|110347412 latent transforming growth factor beta binding prot... 39 0.003
gi|110347431 latent transforming growth factor beta binding prot... 39 0.003
gi|4505579 furin preproprotein [Homo sapiens] 39 0.004
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 39 0.005
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu... 39 0.005
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu... 39 0.005
gi|145309306 scavenger receptor class F, member 1 isoform 5 prec... 39 0.005
>gi|222446611 R-spondin family, member 2 [Homo sapiens]
Length = 243
Score = 536 bits (1381), Expect = e-153
Identities = 243/243 (100%), Positives = 243/243 (100%)
Query: 1 MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF 60
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
Sbjct: 1 MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF 60
Query: 61 FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH 120
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
Sbjct: 61 FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH 120
Query: 121 RGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP 180
RGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
Sbjct: 121 RGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP 180
Query: 181 VKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDR 240
VKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDR
Sbjct: 181 VKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDR 240
Query: 241 ANQ 243
ANQ
Sbjct: 241 ANQ 243
>gi|18490982 R-spondin 3 [Homo sapiens]
Length = 272
Score = 228 bits (582), Expect = 3e-60
Identities = 107/226 (47%), Positives = 143/226 (63%), Gaps = 5/226 (2%)
Query: 1 MQFRLFSFALIILNCMDYSHCQG-NRWRRSKRASYVSNPICKG-CLSCSKDNGCSRCQQK 58
M RL S+ IILN M+Y Q +R RR +R + C+G C +CS NGC C+ +
Sbjct: 1 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR 60
Query: 59 LFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFY 118
LFF L R GM+Q G CL SCPSGYYG R PD+N+C +C+ + CD+CF+K+FCTKCK GFY
Sbjct: 61 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFY 119
Query: 119 LHRGRCFDECPDGFAPLEETMECVE--GCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQI 176
LH G+C D CP+G TMECV CEV W+ W C++ +TCGFK G ETR R+I
Sbjct: 120 LHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREI 179
Query: 177 VKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKR 222
++ P LCP E+R+C + + C G+R K +E++ KK +
Sbjct: 180 IQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNK 225
>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
sapiens]
Length = 234
Score = 210 bits (534), Expect = 1e-54
Identities = 94/204 (46%), Positives = 130/204 (63%), Gaps = 6/204 (2%)
Query: 27 RRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHR 86
RR K+ C GC+ CS++NGCS CQQ+LF F+RREG+RQYG+CLH CP GY+G R
Sbjct: 22 RRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIR 81
Query: 87 APDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCE 146
++NRC +C C+SCFS+DFC +CK FYL++G+C CP G + T EC CE
Sbjct: 82 GQEVNRCKKCGA-TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE 140
Query: 147 VGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGG 206
+G W W C+ N +TCG WGLE+R R+ + ++ C ++ESR+C + R CP G
Sbjct: 141 LGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPI-QRPCP-G 198
Query: 207 KRTP---KAKEKRNKKKKRKLIER 227
+R+P K ++ R +K RKL R
Sbjct: 199 ERSPGQKKGRKDRRPRKDRKLDRR 222
>gi|84490388 R-spondin1 [Homo sapiens]
Length = 263
Score = 208 bits (530), Expect = 3e-54
Identities = 93/213 (43%), Positives = 129/213 (60%), Gaps = 3/213 (1%)
Query: 22 QGNRWRRSKRASYVSNPIC-KGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPS 80
+G + +R +R S + C KGC CS+ NGC +C KLF L R +RQ G CL SCP
Sbjct: 22 RGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPP 81
Query: 81 GYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETME 140
GY+ R PDMN+C +C+IE+C++CFS +FCTKCK G YLH+GRC+ CP+G + TME
Sbjct: 82 GYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTME 141
Query: 141 CVE--GCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKM 198
C CE+ WS WG CS+ + CGF+ G E RTR+++ PV D C E+RRC +
Sbjct: 142 CSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTV 201
Query: 199 TMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQ 231
CP G++ K + R + R L + ++
Sbjct: 202 RRVPCPEGQKRRKGGQGRRENANRNLARKESKE 234
>gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo
sapiens]
Length = 172
Score = 146 bits (368), Expect = 2e-35
Identities = 61/117 (52%), Positives = 80/117 (68%), Gaps = 1/117 (0%)
Query: 27 RRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHR 86
RR K+ C GC+ CS++NGCS CQQ+LF F+RREG+RQYG+CLH CP GY+G R
Sbjct: 22 RRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIR 81
Query: 87 APDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVE 143
++NRC +C C+SCFS+DFC +CK FYL++G+C CP G + T EC E
Sbjct: 82 GQEVNRCKKCG-ATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQE 137
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 55.5 bits (132), Expect = 4e-08
Identities = 38/125 (30%), Positives = 54/125 (43%), Gaps = 15/125 (12%)
Query: 13 LNCMD-YSHCQGNRWRRSKRASYVSNPICKG---CLSCSKDNGCSRCQQKLFFFLRREGM 68
L CMD Y G + + Y + +CK CL C + C+RC+ FL E
Sbjct: 974 LQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECTRCKGP---FLLLEA- 1029
Query: 69 RQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDEC 128
+C+ C GY+ A ++C C + C C +D C C GF+L G C C
Sbjct: 1030 ----QCVQECGKGYFADHAK--HKCTACP-QGCLQCSHRDRCHLCDHGFFLKSGLCVYNC 1082
Query: 129 PDGFA 133
GF+
Sbjct: 1083 VPGFS 1087
Score = 52.4 bits (124), Expect = 4e-07
Identities = 48/196 (24%), Positives = 72/196 (36%), Gaps = 56/196 (28%)
Query: 43 CLSCSKD-NGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENC 101
CL+CS+ + C CQ + Q G C+HSC G+Y +A + C C+ + C
Sbjct: 425 CLTCSQSPDHCDLCQDPT-------KLLQNGWCVHSCGLGFY--QAGSL--CLACQPQ-C 472
Query: 102 DSCFSKDFCTKCKVGFYLHRGRCFDECPDGFA---------------------------- 133
+C S C+ C+ + G+C C DGF
Sbjct: 473 STCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACR 532
Query: 134 -PLEETME--CVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTI 190
PL + C C G ++ GTCS +++C R +K T+
Sbjct: 533 DPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEK---------TV 583
Query: 191 AESRRCKMTMRHCPGG 206
+C M CPGG
Sbjct: 584 LHDGKC---MSECPGG 596
Score = 49.3 bits (116), Expect = 3e-06
Identities = 31/111 (27%), Positives = 49/111 (44%), Gaps = 14/111 (12%)
Query: 23 GNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGY 82
G+ + + + + V + C GC ++ + C C+ L + G C SC G+
Sbjct: 500 GDGFYQDRHSCAVCHESCAGCWGPTEKH-CLACRDPLHVL-------RDGGCESSCGKGF 551
Query: 83 YGHRAPDMNRCARCRIENCDSCF-SKDFCTKCKVGFYLHRGRCFDECPDGF 132
Y + C+ C ++CDSC S C C LH G+C ECP G+
Sbjct: 552 YNRQGT----CSACD-QSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGY 597
Score = 47.4 bits (111), Expect = 1e-05
Identities = 39/140 (27%), Positives = 54/140 (38%), Gaps = 16/140 (11%)
Query: 22 QGNRWRRSKRASYVSNPICKGC----LSC-----SKDNGCSRCQQKLFFFLRREGMRQYG 72
QG+ R Y + +CK C L+C S GC + ++ L + G
Sbjct: 634 QGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSG 693
Query: 73 ECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKD--FCTKCKVGFYLHRGRCFDECPD 130
ECL C + +Y C C ++C C K CT C L G+C +CPD
Sbjct: 694 ECLAQCRAHFY---LESTGICEACH-QSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPD 749
Query: 131 GFAPLE-ETMECVEGCEVGH 149
G+ E EC C H
Sbjct: 750 GYFHQEGSCTECHPTCRQCH 769
Score = 45.4 bits (106), Expect = 4e-05
Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 15/95 (15%)
Query: 41 KGCLSCSKDNG-CSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIE 99
+ C SC + C C +K G+C+ CP GYY A RC C
Sbjct: 563 QSCDSCGPSSPRCLTCTEKTVL--------HDGKCMSECPGGYY---ADATGRCKVCH-N 610
Query: 100 NCDSCF--SKDFCTKCKVGFYLHRGRCFDECPDGF 132
+C SC + CT C L +G C C +GF
Sbjct: 611 SCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGF 645
Score = 42.4 bits (98), Expect = 4e-04
Identities = 31/116 (26%), Positives = 45/116 (38%), Gaps = 13/116 (11%)
Query: 33 SYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLH-SCPSGYYGHRAPDMN 91
++V P C SC C+ C+ L +GEC + SC YY + N
Sbjct: 903 NHVCQPCNTHCGSCDSQASCTSCRDPNKVLL-------FGECQYESCAPQYYLDFST--N 953
Query: 92 RCARCRIENCDSCFS--KDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGC 145
C C +C +C K C +C G+ L G C ++C F +C C
Sbjct: 954 TCKECDW-SCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYC 1008
Score = 41.6 bits (96), Expect = 6e-04
Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 17/98 (17%)
Query: 39 ICKGCLSCSKDNG--CSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARC 96
+C+ C + + G C RCQ + L C+ CPSGYY R C +C
Sbjct: 812 LCQHCAADLHNTGSICLRCQNAHYLLLG-------DHCVPDCPSGYYAER----GACKKC 860
Query: 97 RIENCDSCFSKD--FCTKCKVGFYL-HRGRCFDECPDG 131
+C +C + C+ C L H G C C G
Sbjct: 861 H-SSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPG 897
Score = 35.0 bits (79), Expect = 0.059
Identities = 39/163 (23%), Positives = 56/163 (34%), Gaps = 40/163 (24%)
Query: 36 SNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQY---GECLHSCPSGYYGHRA----- 87
S IC+ C C RC K G G+CL CP GY+
Sbjct: 707 STGICEAC-----HQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTEC 761
Query: 88 -PDMNRCARCRIENCDSCF------SKDFCTKCKVGFYLHR-GRCFD---ECPDGFAPLE 136
P +C +C SC+ + + T C+ +L+ G C D C A L
Sbjct: 762 HPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLH 821
Query: 137 ETME----------------CVEGCEVGHWSEWGTCSRNNRTC 163
T CV C G+++E G C + + +C
Sbjct: 822 NTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSC 864
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 55.1 bits (131), Expect = 6e-08
Identities = 35/113 (30%), Positives = 45/113 (39%), Gaps = 10/113 (8%)
Query: 19 SHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSC 78
S C + K+ P C+ C D C C K +FL E C+ C
Sbjct: 672 SSCPPGHYHADKKRCRKCAPNCESCFGSHGDQ-CMSC--KYGYFLNEET----NSCVTHC 724
Query: 79 PSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDG 131
P G Y + N C +C ENC +C CT+C+ G L RC C DG
Sbjct: 725 PDGSY--QDTKKNLCRKCS-ENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG 774
Score = 54.7 bits (130), Expect = 7e-08
Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 13/103 (12%)
Query: 51 GCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK--D 108
G C L ++ + + + C+ SCP G+Y D RC +C NC+SCF D
Sbjct: 649 GPDHCNDCLHYYYKLKNNTRI--CVSSCPPGHY---HADKKRCRKC-APNCESCFGSHGD 702
Query: 109 FCTKCKVGFYLHR--GRCFDECPDG-FAPLEETM--ECVEGCE 146
C CK G++L+ C CPDG + ++ + +C E C+
Sbjct: 703 QCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCK 745
Score = 42.0 bits (97), Expect = 5e-04
Identities = 28/113 (24%), Positives = 46/113 (40%), Gaps = 19/113 (16%)
Query: 19 SHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGE-CLHS 77
+HC ++ +K+ + + C +C++ + C+ C R+G+ G C S
Sbjct: 722 THCPDGSYQDTKKN--LCRKCSENCKTCTEFHNCTEC---------RDGLSLQGSRCSVS 770
Query: 78 CPSGYYGHRAPDMNRCARCRIENCDSCFSK--DFCTKCKVGFYLHRGRCFDEC 128
C G Y D C R C +C D C C G+++ GRC C
Sbjct: 771 CEDGRY-FNGQDCQPCHRF----CATCAGAGADGCINCTEGYFMEDGRCVQSC 818
Score = 40.4 bits (93), Expect = 0.001
Identities = 34/130 (26%), Positives = 47/130 (36%), Gaps = 28/130 (21%)
Query: 40 CKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPD--MNRCARCR 97
C C D GC C + F + G C+ SC YY + + C +C
Sbjct: 789 CATCAGAGAD-GCINCTEGYFM--------EDGRCVQSCSISYYFDHSSENGYKSCKKCD 839
Query: 98 IENCDSCFSKDF--CTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGT 155
I +C +C F CT C G+ L G C + C + E W+E G
Sbjct: 840 I-SCLTCNGPGFKNCTSCPSGYLLDLGMC-----------QMGAICKDATEES-WAEGGF 886
Query: 156 CS--RNNRTC 163
C + N C
Sbjct: 887 CMLVKKNNLC 896
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 52.8 bits (125), Expect = 3e-07
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 14/140 (10%)
Query: 13 LNCMDYSHCQGNRWRRSKRA---SYVSNPICKGCLSCSKDNGCSRCQQKLFF--FLRREG 67
LNC+ +S R+ Y + + C C K GC C + R G
Sbjct: 700 LNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK--GCETCSSRAATQCLSCRRG 757
Query: 68 MRQYGE---CLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK-DFCTKCKVGFYLHRGR 123
+ E C+ CP+G+Y + C +C +C C + + CT CK GF L RG
Sbjct: 758 FYHHQEMNTCVTLCPAGFYADES--QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGS 814
Query: 124 CFDECPDGFAPLEETMECVE 143
C +C G E + C E
Sbjct: 815 CIPDCEPGTYFDSELIRCGE 834
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 52.8 bits (125), Expect = 3e-07
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 14/140 (10%)
Query: 13 LNCMDYSHCQGNRWRRSKRA---SYVSNPICKGCLSCSKDNGCSRCQQKLFF--FLRREG 67
LNC+ +S R+ Y + + C C K GC C + R G
Sbjct: 713 LNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK--GCETCSSRAATQCLSCRRG 770
Query: 68 MRQYGE---CLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK-DFCTKCKVGFYLHRGR 123
+ E C+ CP+G+Y + C +C +C C + + CT CK GF L RG
Sbjct: 771 FYHHQEMNTCVTLCPAGFYADES--QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGS 827
Query: 124 CFDECPDGFAPLEETMECVE 143
C +C G E + C E
Sbjct: 828 CIPDCEPGTYFDSELIRCGE 847
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 52.8 bits (125), Expect = 3e-07
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 14/140 (10%)
Query: 13 LNCMDYSHCQGNRWRRSKRA---SYVSNPICKGCLSCSKDNGCSRCQQKLFF--FLRREG 67
LNC+ +S R+ Y + + C C K GC C + R G
Sbjct: 713 LNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK--GCETCSSRAATQCLSCRRG 770
Query: 68 MRQYGE---CLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK-DFCTKCKVGFYLHRGR 123
+ E C+ CP+G+Y + C +C +C C + + CT CK GF L RG
Sbjct: 771 FYHHQEMNTCVTLCPAGFYADES--QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGS 827
Query: 124 CFDECPDGFAPLEETMECVE 143
C +C G E + C E
Sbjct: 828 CIPDCEPGTYFDSELIRCGE 847
Score = 37.0 bits (84), Expect = 0.016
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 13/81 (16%)
Query: 40 CKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNR--CARCR 97
C C+ ++ C C + F +C+ +C G+Y P + C RC
Sbjct: 852 CGTCVGPGREE-CIHCAKNFHF--------HDWKCVPACGEGFYPEEMPGLPHKVCRRCD 902
Query: 98 IENCDSCF-SKDFCTKCKVGF 117
ENC SC S C++CK GF
Sbjct: 903 -ENCLSCAGSSRNCSRCKTGF 922
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 52.8 bits (125), Expect = 3e-07
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 14/140 (10%)
Query: 13 LNCMDYSHCQGNRWRRSKRA---SYVSNPICKGCLSCSKDNGCSRCQQKLFF--FLRREG 67
LNC+ +S R+ Y + + C C K GC C + R G
Sbjct: 700 LNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK--GCETCSSRAATQCLSCRRG 757
Query: 68 MRQYGE---CLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK-DFCTKCKVGFYLHRGR 123
+ E C+ CP+G+Y + C +C +C C + + CT CK GF L RG
Sbjct: 758 FYHHQEMNTCVTLCPAGFYADES--QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGS 814
Query: 124 CFDECPDGFAPLEETMECVE 143
C +C G E + C E
Sbjct: 815 CIPDCEPGTYFDSELIRCGE 834
Score = 37.0 bits (84), Expect = 0.016
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 13/81 (16%)
Query: 40 CKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNR--CARCR 97
C C+ ++ C C + F +C+ +C G+Y P + C RC
Sbjct: 839 CGTCVGPGREE-CIHCAKNFHF--------HDWKCVPACGEGFYPEEMPGLPHKVCRRCD 889
Query: 98 IENCDSCF-SKDFCTKCKVGF 117
ENC SC S C++CK GF
Sbjct: 890 -ENCLSCAGSSRNCSRCKTGF 909
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 52.4 bits (124), Expect = 4e-07
Identities = 38/129 (29%), Positives = 56/129 (43%), Gaps = 22/129 (17%)
Query: 41 KGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHS---CPSGYYGHRAPDMNRCARCR 97
K CL+CS C+ CQ+ L M G C+ + PS Y+ AP C C
Sbjct: 416 KSCLTCSSSGTCTTCQKGLI-------MNPRGSCMANEKCSPSEYWDEDAPG---CKPCH 465
Query: 98 IENCDSCF--SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGT 155
++ C C ++D C C + L C +CP+G+ E++ C C S T
Sbjct: 466 VK-CFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAH-CH----SSCRT 519
Query: 156 C-SRNNRTC 163
C R++R C
Sbjct: 520 CEGRHSRQC 528
Score = 51.2 bits (121), Expect = 8e-07
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 31/156 (19%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSG 81
+G W R + CK C + C+ C + + + C+ SCP G
Sbjct: 162 EGKFWNDILRKLQPCHSSCKTCNGSA--TLCTSCPKGAYLLAQA--------CVSSCPQG 211
Query: 82 YYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVG----FYLHRGRCFDECPDGFAPLEE 137
+ + C C E C C D C KC++ +LH GRC+ +CP+G +
Sbjct: 212 TWP--SVRSGSCENCT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDG 268
Query: 138 TME-------CVEG-------CEVGHWSEWGTCSRN 159
E EG CE GH G C N
Sbjct: 269 ICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQEN 304
Score = 51.2 bits (121), Expect = 8e-07
Identities = 33/94 (35%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 37 NPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARC 96
N CKGC + C C + FFFL +R GEC SCP YY ++ C RC
Sbjct: 563 NRSCKGCQG-PRPTDCLSCDR--FFFL----LRSKGECHRSCPDHYYVEQS--TQTCERC 613
Query: 97 RIENCDSCFSKDF--CTKCKVGFYLHRGRCFDEC 128
CD C K C C ++L G C +C
Sbjct: 614 H-PTCDQCKGKGALNCLSCVWSYHLMGGICTSDC 646
Score = 49.3 bits (116), Expect = 3e-06
Identities = 33/127 (25%), Positives = 48/127 (37%), Gaps = 13/127 (10%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREG--MRQYGECLHSCP 79
+G + + SY + IC+ C S C C+ EG + +G C +CP
Sbjct: 252 EGRCYSKCPEGSYAEDGICERCSS-----PCRTCEGNATNCHSCEGGHVLHHGVCQENCP 306
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGF-APLEET 138
+ C C E C C + C +C F+LH C CP GF A
Sbjct: 307 ERHVAVEGV----CKHCP-EMCQDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHC 361
Query: 139 MECVEGC 145
+ C + C
Sbjct: 362 VPCHKDC 368
Score = 48.9 bits (115), Expect = 4e-06
Identities = 36/124 (29%), Positives = 50/124 (40%), Gaps = 16/124 (12%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPS 80
CQ N R V + C C + C C + FFL + C SCP
Sbjct: 301 CQENCPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPE--FFLHDD------MCHQSCPR 352
Query: 81 GYYGHRAPDMNRCARCRIENCDSCFSK--DFCTKC-KVGFYLHRGRCFDECPDGFAPLEE 137
G+Y D + C C ++C C D C C + + L+ G C +ECP G ++
Sbjct: 353 GFYA----DSHHCVPCH-KDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQ 407
Query: 138 TMEC 141
T EC
Sbjct: 408 TKEC 411
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/146 (25%), Positives = 53/146 (36%), Gaps = 31/146 (21%)
Query: 31 RASYVSNPICKGCLSCSKDN-GCSRCQQKLFFFLR----------REGMRQYGECLHSCP 79
R S ++N C +D GC C K F + + C+ CP
Sbjct: 439 RGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCP 498
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDF--CTKCKVGFYLHRGRCFDECPDGFAPLEE 137
GYY D NRCA C +C +C + C C+ G++ C +C +G+
Sbjct: 499 EGYYADE--DSNRCAHCH-SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNS 555
Query: 138 TMECVEGCEVGHWSEWGTCSRNNRTC 163
T G C R NR+C
Sbjct: 556 T---------------GRCERCNRSC 566
Score = 42.7 bits (99), Expect = 3e-04
Identities = 29/82 (35%), Positives = 34/82 (41%), Gaps = 8/82 (9%)
Query: 65 REGMRQYG-ECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK--DFCTKCKVGFYLHR 121
R G Q G ECL C GYY + RC RC +C C C C F+L R
Sbjct: 532 RPGWFQLGKECLLQCREGYYADNST--GRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLR 588
Query: 122 --GRCFDECPDGFAPLEETMEC 141
G C CPD + + T C
Sbjct: 589 SKGECHRSCPDHYYVEQSTQTC 610
Score = 42.4 bits (98), Expect = 4e-04
Identities = 40/181 (22%), Positives = 55/181 (30%), Gaps = 62/181 (34%)
Query: 20 HCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCP 79
HC ++ +Y CK C D+ CS C Q ++ G C+ C
Sbjct: 59 HC----YKTCPEKTYSEAVECKAC-----DSNCSSCDQNGCYWCEEGFFLLGGSCVRKCG 109
Query: 80 SGYYG----------HRA------PDMNRCARCRI------------------------- 98
G+YG HRA P + C+ C+
Sbjct: 110 PGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDI 169
Query: 99 --------ENCDSCF-SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEET---MECVEGCE 146
+C +C S CT C G YL C CP G P + C E C
Sbjct: 170 LRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229
Query: 147 V 147
+
Sbjct: 230 I 230
Score = 41.6 bits (96), Expect = 6e-04
Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 7/79 (8%)
Query: 67 GMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFD 126
G R C +CP Y C C NC SC ++ C C+ GF+L G C
Sbjct: 53 GNRFDHHCYKTCPEKTYSEAV----ECKACD-SNCSSC-DQNGCYWCEEGFFLLGGSCVR 106
Query: 127 ECPDGFAPLEETMECVEGC 145
+C GF +E EC E C
Sbjct: 107 KCGPGFYGDQEMGEC-ESC 124
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 52.4 bits (124), Expect = 4e-07
Identities = 38/129 (29%), Positives = 56/129 (43%), Gaps = 22/129 (17%)
Query: 41 KGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHS---CPSGYYGHRAPDMNRCARCR 97
K CL+CS C+ CQ+ L M G C+ + PS Y+ AP C C
Sbjct: 416 KSCLTCSSSGTCTTCQKGLI-------MNPRGSCMANEKCSPSEYWDEDAPG---CKPCH 465
Query: 98 IENCDSCF--SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGT 155
++ C C ++D C C + L C +CP+G+ E++ C C S T
Sbjct: 466 VK-CFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAH-CH----SSCRT 519
Query: 156 C-SRNNRTC 163
C R++R C
Sbjct: 520 CEGRHSRQC 528
Score = 51.2 bits (121), Expect = 8e-07
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 31/156 (19%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSG 81
+G W R + CK C + C+ C + + + C+ SCP G
Sbjct: 162 EGKFWNDILRKLQPCHSSCKTCNGSA--TLCTSCPKGAYLLAQA--------CVSSCPQG 211
Query: 82 YYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVG----FYLHRGRCFDECPDGFAPLEE 137
+ + C C E C C D C KC++ +LH GRC+ +CP+G +
Sbjct: 212 TWP--SVRSGSCENCT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDG 268
Query: 138 TME-------CVEG-------CEVGHWSEWGTCSRN 159
E EG CE GH G C N
Sbjct: 269 ICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQEN 304
Score = 51.2 bits (121), Expect = 8e-07
Identities = 33/94 (35%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 37 NPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARC 96
N CKGC + C C + FFFL +R GEC SCP YY ++ C RC
Sbjct: 563 NRSCKGCQG-PRPTDCLSCDR--FFFL----LRSKGECHRSCPDHYYVEQS--TQTCERC 613
Query: 97 RIENCDSCFSKDF--CTKCKVGFYLHRGRCFDEC 128
CD C K C C ++L G C +C
Sbjct: 614 H-PTCDQCKGKGALNCLSCVWSYHLMGGICTSDC 646
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/127 (25%), Positives = 49/127 (38%), Gaps = 13/127 (10%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREG--MRQYGECLHSCP 79
+G + + SY + IC+ C S C C+ EG + +G C +CP
Sbjct: 252 EGRCYSKCPEGSYAEDGICERCSS-----PCRTCEGNATNCHSCEGGHVLHHGVCQENCP 306
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGF-APLEET 138
+ + C C E C C + C +C F+LH C CP GF A
Sbjct: 307 ERHVAVKGV----CKHCP-EMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHC 361
Query: 139 MECVEGC 145
+ C + C
Sbjct: 362 VPCHKDC 368
Score = 49.7 bits (117), Expect = 2e-06
Identities = 36/124 (29%), Positives = 47/124 (37%), Gaps = 16/124 (12%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPS 80
CQ N R V + C C + C C + FFL + C SCP
Sbjct: 301 CQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPE--FFLHDD------MCHQSCPR 352
Query: 81 GYYG---HRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEE 137
G+Y H P C C D C + C + + L+ G C +ECP G +E
Sbjct: 353 GFYADSRHCVPCHKDCLECSGPKADDC---ELCLESS--WVLYDGLCLEECPAGTYYEKE 407
Query: 138 TMEC 141
T EC
Sbjct: 408 TKEC 411
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/146 (25%), Positives = 53/146 (36%), Gaps = 31/146 (21%)
Query: 31 RASYVSNPICKGCLSCSKDN-GCSRCQQKLFFFLR----------REGMRQYGECLHSCP 79
R S ++N C +D GC C K F + + C+ CP
Sbjct: 439 RGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCP 498
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDF--CTKCKVGFYLHRGRCFDECPDGFAPLEE 137
GYY D NRCA C +C +C + C C+ G++ C +C +G+
Sbjct: 499 EGYYADE--DSNRCAHCH-SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNS 555
Query: 138 TMECVEGCEVGHWSEWGTCSRNNRTC 163
T G C R NR+C
Sbjct: 556 T---------------GRCERCNRSC 566
Score = 42.7 bits (99), Expect = 3e-04
Identities = 29/82 (35%), Positives = 34/82 (41%), Gaps = 8/82 (9%)
Query: 65 REGMRQYG-ECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK--DFCTKCKVGFYLHR 121
R G Q G ECL C GYY + RC RC +C C C C F+L R
Sbjct: 532 RPGWFQLGKECLLQCREGYYADNST--GRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLR 588
Query: 122 --GRCFDECPDGFAPLEETMEC 141
G C CPD + + T C
Sbjct: 589 SKGECHRSCPDHYYVEQSTQTC 610
Score = 41.2 bits (95), Expect = 8e-04
Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 7/79 (8%)
Query: 67 GMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFD 126
G R C +CP Y C C NC SC ++ C C+ GF+L G C
Sbjct: 53 GNRFDHHCYKTCPEKTYSEAV----ECKACD-SNCGSC-DQNGCYWCEEGFFLLGGSCVR 106
Query: 127 ECPDGFAPLEETMECVEGC 145
+C GF +E EC E C
Sbjct: 107 KCGPGFYGDQEMGEC-ESC 124
Score = 40.8 bits (94), Expect = 0.001
Identities = 31/112 (27%), Positives = 42/112 (37%), Gaps = 13/112 (11%)
Query: 40 CKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIE 99
C+ C D CS CQ+ L G C+H+ + G D+ R +
Sbjct: 128 CETCTGPGHDE-CSSCQEGLQLLR--------GMCVHATKTQEEGKFWNDILRKLQPCHS 178
Query: 100 NCDSCF-SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEET---MECVEGCEV 147
+C +C S CT C G YL C CP G P + C E C +
Sbjct: 179 SCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAI 230
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 52.4 bits (124), Expect = 4e-07
Identities = 38/129 (29%), Positives = 56/129 (43%), Gaps = 22/129 (17%)
Query: 41 KGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHS---CPSGYYGHRAPDMNRCARCR 97
K CL+CS C+ CQ+ L M G C+ + PS Y+ AP C C
Sbjct: 416 KSCLTCSSSGTCTTCQKGLI-------MNPRGSCMANEKCSPSEYWDEDAPG---CKPCH 465
Query: 98 IENCDSCF--SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGT 155
++ C C ++D C C + L C +CP+G+ E++ C C S T
Sbjct: 466 VK-CFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAH-CH----SSCRT 519
Query: 156 C-SRNNRTC 163
C R++R C
Sbjct: 520 CEGRHSRQC 528
Score = 51.2 bits (121), Expect = 8e-07
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 31/156 (19%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSG 81
+G W R + CK C + C+ C + + + C+ SCP G
Sbjct: 162 EGKFWNDILRKLQPCHSSCKTCNGSA--TLCTSCPKGAYLLAQA--------CVSSCPQG 211
Query: 82 YYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVG----FYLHRGRCFDECPDGFAPLEE 137
+ + C C E C C D C KC++ +LH GRC+ +CP+G +
Sbjct: 212 TWP--SVRSGSCENCT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDG 268
Query: 138 TME-------CVEG-------CEVGHWSEWGTCSRN 159
E EG CE GH G C N
Sbjct: 269 ICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQEN 304
Score = 51.2 bits (121), Expect = 8e-07
Identities = 33/94 (35%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 37 NPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARC 96
N CKGC + C C + FFFL +R GEC SCP YY ++ C RC
Sbjct: 563 NRSCKGCQG-PRPTDCLSCDR--FFFL----LRSKGECHRSCPDHYYVEQS--TQTCERC 613
Query: 97 RIENCDSCFSKDF--CTKCKVGFYLHRGRCFDEC 128
CD C K C C ++L G C +C
Sbjct: 614 H-PTCDQCKGKGALNCLSCVWSYHLMGGICTSDC 646
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/127 (25%), Positives = 49/127 (38%), Gaps = 13/127 (10%)
Query: 22 QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREG--MRQYGECLHSCP 79
+G + + SY + IC+ C S C C+ EG + +G C +CP
Sbjct: 252 EGRCYSKCPEGSYAEDGICERCSS-----PCRTCEGNATNCHSCEGGHVLHHGVCQENCP 306
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGF-APLEET 138
+ + C C E C C + C +C F+LH C CP GF A
Sbjct: 307 ERHVAVKGV----CKHCP-EMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHC 361
Query: 139 MECVEGC 145
+ C + C
Sbjct: 362 VPCHKDC 368
Score = 49.7 bits (117), Expect = 2e-06
Identities = 36/124 (29%), Positives = 47/124 (37%), Gaps = 16/124 (12%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPS 80
CQ N R V + C C + C C + FFL + C SCP
Sbjct: 301 CQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPE--FFLHDD------MCHQSCPR 352
Query: 81 GYYG---HRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEE 137
G+Y H P C C D C + C + + L+ G C +ECP G +E
Sbjct: 353 GFYADSRHCVPCHKDCLECSGPKADDC---ELCLESS--WVLYDGLCLEECPAGTYYEKE 407
Query: 138 TMEC 141
T EC
Sbjct: 408 TKEC 411
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/146 (25%), Positives = 53/146 (36%), Gaps = 31/146 (21%)
Query: 31 RASYVSNPICKGCLSCSKDN-GCSRCQQKLFFFLR----------REGMRQYGECLHSCP 79
R S ++N C +D GC C K F + + C+ CP
Sbjct: 439 RGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCP 498
Query: 80 SGYYGHRAPDMNRCARCRIENCDSCFSKDF--CTKCKVGFYLHRGRCFDECPDGFAPLEE 137
GYY D NRCA C +C +C + C C+ G++ C +C +G+
Sbjct: 499 EGYYADE--DSNRCAHCH-SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNS 555
Query: 138 TMECVEGCEVGHWSEWGTCSRNNRTC 163
T G C R NR+C
Sbjct: 556 T---------------GRCERCNRSC 566
Score = 42.7 bits (99), Expect = 3e-04
Identities = 29/82 (35%), Positives = 34/82 (41%), Gaps = 8/82 (9%)
Query: 65 REGMRQYG-ECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSK--DFCTKCKVGFYLHR 121
R G Q G ECL C GYY + RC RC +C C C C F+L R
Sbjct: 532 RPGWFQLGKECLLQCREGYYADNST--GRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLR 588
Query: 122 --GRCFDECPDGFAPLEETMEC 141
G C CPD + + T C
Sbjct: 589 SKGECHRSCPDHYYVEQSTQTC 610
Score = 41.6 bits (96), Expect = 6e-04
Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 7/79 (8%)
Query: 67 GMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFD 126
G R C +CP Y C C NC SC ++ C C+ GF+L G C
Sbjct: 53 GNRFDHHCYKTCPEKTYSEEV----ECKACD-SNCGSC-DQNGCYWCEEGFFLLGGSCVR 106
Query: 127 ECPDGFAPLEETMECVEGC 145
+C GF +E EC E C
Sbjct: 107 KCGPGFYGDQEMGEC-ESC 124
Score = 41.6 bits (96), Expect = 6e-04
Identities = 39/181 (21%), Positives = 54/181 (29%), Gaps = 62/181 (34%)
Query: 20 HCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCP 79
HC ++ +Y CK C D+ C C Q ++ G C+ C
Sbjct: 59 HC----YKTCPEKTYSEEVECKAC-----DSNCGSCDQNGCYWCEEGFFLLGGSCVRKCG 109
Query: 80 SGYYG----------HRA------PDMNRCARCRI------------------------- 98
G+YG HRA P + C+ C+
Sbjct: 110 PGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDI 169
Query: 99 --------ENCDSCF-SKDFCTKCKVGFYLHRGRCFDECPDGFAPLEET---MECVEGCE 146
+C +C S CT C G YL C CP G P + C E C
Sbjct: 170 LRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229
Query: 147 V 147
+
Sbjct: 230 I 230
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 45.8 bits (107), Expect = 3e-05
Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 11/107 (10%)
Query: 127 ECPDGFAPLEETM--ECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDT 184
+C + +E+ M EC CE+ WS+W C N++CG G RTR I +P
Sbjct: 649 DCNEDLEQVEKCMLPECPIDCELTEWSQWSEC---NKSCG--KGHVIRTRMIQMEPQFGG 703
Query: 185 ILCPTIAESRRCKMTMRHCPGGKRTPKA--KEKRNKKKKRKLIERAQ 229
CP + ++C+ +R C K +E R ++ +L E ++
Sbjct: 704 APCPETVQRKKCR--IRKCLRNPSIQKLRWREARESRRSEQLKEESE 748
Score = 37.0 bits (84), Expect = 0.016
Identities = 22/76 (28%), Positives = 32/76 (42%), Gaps = 12/76 (15%)
Query: 134 PLEETMECV-------EGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTIL 186
P EET +C C + W EW CS TCG G++ R R I P ++
Sbjct: 541 PTEETEKCTVNEECSPSSCLMTEWGEWDECS---ATCGM--GMKKRHRMIKMNPADGSMC 595
Query: 187 CPTIAESRRCKMTMRH 202
+++ +C M H
Sbjct: 596 KAETSQAEKCMMPECH 611
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 42.7 bits (99), Expect = 3e-04
Identities = 41/126 (32%), Positives = 51/126 (40%), Gaps = 30/126 (23%)
Query: 30 KRASYVSNPICKG-CL-SCS---KDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYY- 83
KRA +N C CL SCS D C C+ + G C+ +CP Y
Sbjct: 221 KRACTENNECCHPECLGSCSAPDNDTACVACRHYYYA----------GVCVPACPPNTYR 270
Query: 84 --GHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPL-EETME 140
G R D + CA N S S D GF +H G C ECP GF ++M
Sbjct: 271 FEGWRCVDRDFCA-----NILSAESSD-----SEGFVIHDGECMQECPSGFIRNGSQSMY 320
Query: 141 CVEGCE 146
C+ CE
Sbjct: 321 CIP-CE 325
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 42.7 bits (99), Expect = 3e-04
Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 6/67 (8%)
Query: 141 CVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTM 200
C C V + W CS+ CG K L+ RTR ++ P+ + CP + ESR C +
Sbjct: 145 CPRDCVVSEFLPWSNCSKG---CGKK--LQHRTRAVIAPPLFGGLQCPNLTESRACDAPI 199
Query: 201 RHCPGGK 207
CP G+
Sbjct: 200 -SCPLGE 205
Score = 40.0 bits (92), Expect = 0.002
Identities = 50/225 (22%), Positives = 71/225 (31%), Gaps = 37/225 (16%)
Query: 7 SFALIILNCMDYSHCQGNRWRRSKRASYV--SNPICKGCLSCSKD------NGCSRCQQK 58
SF L + +C+ C+ ++W S S + G S S++ G C +
Sbjct: 292 SFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPE- 350
Query: 59 LFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFY 118
L +E GE L CP Y R + C + C G
Sbjct: 351 ---LLEKEACIVEGELLQQCPR--YSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQ 405
Query: 119 LHRGRCFDECPDGFA--------PLEETM--------------ECVEGCEVGHWSEWGTC 156
C P A P+E+ + C C V WS WG C
Sbjct: 406 TREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLC 465
Query: 157 SRNN-RTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTM 200
N K G TR R ++ + CP + ES C+ M
Sbjct: 466 IHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPM 510
Score = 38.5 bits (88), Expect = 0.005
Identities = 19/78 (24%), Positives = 32/78 (41%), Gaps = 3/78 (3%)
Query: 130 DGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPT 189
D F ++ + CE WS W CS+ R+ G +R+R + + CP
Sbjct: 291 DSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPE 350
Query: 190 IAESRRCKM---TMRHCP 204
+ E C + ++ CP
Sbjct: 351 LLEKEACIVEGELLQQCP 368
Score = 38.5 bits (88), Expect = 0.005
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 5/62 (8%)
Query: 139 MECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPT-IAESRRCK 197
+ECV C++ W+ W CS +TCG G +RTR I+ + CPT + + + C
Sbjct: 1213 VECVVNCQLSGWTAWTECS---QTCG-HGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCP 1268
Query: 198 MT 199
+T
Sbjct: 1269 VT 1270
Score = 35.4 bits (80), Expect = 0.045
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 5/60 (8%)
Query: 131 GFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTI 190
G+ + + C C++ WS WG+CS +CG G+ R++ + +KP CP +
Sbjct: 956 GYIQEKCVIPCPFDCKLSDWSSWGSCS---SSCGI--GVRIRSKWLKEKPYNGGRPCPKL 1010
Score = 34.3 bits (77), Expect = 0.10
Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 14/95 (14%)
Query: 109 FCTKCKVGFYLHRGRCFDECPDGFAPLEETME-----CVEGCEVGHWSEWGTCSRNNRTC 163
FC K VG + + CPD P ET+ C + C V +SEW C R +
Sbjct: 673 FCVKSHVGQVMTK-----RCPDSTRP--ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQ-A 724
Query: 164 GFKWGLETRTRQIVKKPVKDTILCP-TIAESRRCK 197
G ++R R I+++ CP T+ E R C+
Sbjct: 725 GNATVKQSRYRIIIQEAANGGQECPDTLYEERECE 759
Score = 32.0 bits (71), Expect = 0.50
Identities = 27/101 (26%), Positives = 44/101 (43%), Gaps = 19/101 (18%)
Query: 112 KCKVGFYLHRGRCFDE---------CPDGFAPLEETME--CVEGCEVGHWSEWGTCSRNN 160
KC +G + + C ++ CP P ++ E C C + W+EW +CS
Sbjct: 527 KCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCS--- 583
Query: 161 RTCGFK--WGLETRTRQIVKKPVKDTILCP---TIAESRRC 196
++C K G +TR+R I+ + CP + E R C
Sbjct: 584 QSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLC 624
Score = 31.2 bits (69), Expect = 0.85
Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 9/65 (13%)
Query: 138 TMECVEGCEVGHWSEWGTCSRNNRTC----GFKW-GLETRTRQIVKKPVKDTILCP-TIA 191
++ C C + WSEW TC TC F+ G ++R+R + + ++ CP +
Sbjct: 1335 SVPCPGDCHLTEWSEWSTC---ELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVL 1391
Query: 192 ESRRC 196
E+R C
Sbjct: 1392 ETRPC 1396
>gi|119395738 insulin receptor isoform Short precursor [Homo
sapiens]
Length = 1370
Score = 41.2 bits (95), Expect = 8e-04
Identities = 34/137 (24%), Positives = 53/137 (38%), Gaps = 27/137 (19%)
Query: 15 CMDYSHCQGNRWRRSKRASYVSNPIC--KGCL-SCSKDNGCSRCQQKLFFFLRREGMRQY 71
C +SHCQ K + +C CL +CS+ + ++C F+L
Sbjct: 209 CWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLD------- 261
Query: 72 GECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVG-------FYLHRGRC 124
G C+ +CP YY + RC + F +D KCK + +H +C
Sbjct: 262 GRCVETCPPPYYHFQDW---RCV-------NFSFCQDLHHKCKNSRRQGCHQYVIHNNKC 311
Query: 125 FDECPDGFAPLEETMEC 141
ECP G+ + C
Sbjct: 312 IPECPSGYTMNSSNLLC 328
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 41.2 bits (95), Expect = 8e-04
Identities = 34/137 (24%), Positives = 53/137 (38%), Gaps = 27/137 (19%)
Query: 15 CMDYSHCQGNRWRRSKRASYVSNPIC--KGCL-SCSKDNGCSRCQQKLFFFLRREGMRQY 71
C +SHCQ K + +C CL +CS+ + ++C F+L
Sbjct: 209 CWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLD------- 261
Query: 72 GECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVG-------FYLHRGRC 124
G C+ +CP YY + RC + F +D KCK + +H +C
Sbjct: 262 GRCVETCPPPYYHFQDW---RCV-------NFSFCQDLHHKCKNSRRQGCHQYVIHNNKC 311
Query: 125 FDECPDGFAPLEETMEC 141
ECP G+ + C
Sbjct: 312 IPECPSGYTMNSSNLLC 328
>gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]
Length = 331
Score = 40.4 bits (93), Expect = 0.001
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 145 CEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRC 196
CEV WS WG C + CG + G ++RTR + +P + CP + E C
Sbjct: 278 CEVSLWSSWGLCGGH---CG-RLGTKSRTRYVRVQPANNGSPCPELEEEAEC 325
>gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]
Length = 331
Score = 40.4 bits (93), Expect = 0.001
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 145 CEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRC 196
CEV WS WG C + CG + G ++RTR + +P + CP + E C
Sbjct: 278 CEVSLWSSWGLCGGH---CG-RLGTKSRTRYVRVQPANNGSPCPELEEEAEC 325
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 39.7 bits (91), Expect = 0.002
Identities = 18/52 (34%), Positives = 22/52 (42%)
Query: 145 CEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRC 196
C+V WSEW CS+ G RTR I + P+ CP E C
Sbjct: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412
Score = 39.3 bits (90), Expect = 0.003
Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 141 CVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCK 197
C + C V +S W CS+ TCG GL+ RTR +V P CP + E + C+
Sbjct: 191 CQQDCIVSEFSAWSECSK---TCGS--GLQHRTRHVVAPPQFGGSGCPNLTEFQVCQ 242
Score = 35.4 bits (80), Expect = 0.045
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 141 CVEGCEVGHWSEWGTCSRNN-RTCGFKWGLETRTRQIVKKPVKD---TILCPTIAESRRC 196
C CEV WS WG C+ N K G + R R+I +P T CP + E+ C
Sbjct: 509 CPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPC 568
Query: 197 K 197
+
Sbjct: 569 E 569
Score = 34.3 bits (77), Expect = 0.10
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 141 CVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTI 190
C C++ WS W CS ++CG G++ R++ + +KP CP +
Sbjct: 1032 CPSDCKLSEWSNWSRCS---KSCGS--GVKVRSKWLREKPYNGGRPCPKL 1076
Score = 33.9 bits (76), Expect = 0.13
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 4/57 (7%)
Query: 139 MECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRR 195
+EC C++ WS W CS +TCG G R R + + D CP++ + +
Sbjct: 1281 VECPVNCQLSDWSPWSECS---QTCGLT-GKMIRRRTVTQPFQGDGRPCPSLMDQSK 1333
Score = 33.5 bits (75), Expect = 0.17
Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 7/68 (10%)
Query: 135 LEETME--CVEGCEVGHWSEWGTCSR---NNRTCGFKWGLETRTRQIVKKPVKDTILCP- 188
LEE+ C C + WS W C N GF G++ R+R ++ + +++ LCP
Sbjct: 1403 LEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGF-GGIQVRSRPVIIQELENQHLCPE 1461
Query: 189 TIAESRRC 196
+ E++ C
Sbjct: 1462 QMLETKSC 1469
Score = 30.8 bits (68), Expect = 1.1
Identities = 13/60 (21%), Positives = 22/60 (36%), Gaps = 4/60 (6%)
Query: 139 MECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKM 198
+ C E C + W W C F+ R+ +++P + CP E C +
Sbjct: 1160 LPCPEDCVISEWGPWTQCVLPCNQSSFR----QRSADPIRQPADEGRSCPNAVEKEPCNL 1215
Score = 30.4 bits (67), Expect = 1.5
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 11/77 (14%)
Query: 128 CPDGFAPLEETME--CVEGCEVGHWSEWGTCSRNNRTCGFKW--GLETRTRQIVKKPVKD 183
C D P+ + C + C + WS W +CS TC K G + R R I+ ++
Sbjct: 616 CRDAIFPIPVACDAPCPKDCVLSTWSTWSSCS---HTCSGKTTEGKQIRARSILAYAGEE 672
Query: 184 -TILCP---TIAESRRC 196
I CP + E R C
Sbjct: 673 GGIRCPNSSALQEVRSC 689
Score = 27.7 bits (60), Expect = 9.4
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 12/61 (19%)
Query: 141 CVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIV-----KKPVKDTILCPTIAESRR 195
C + C++ WS++ +C N CG + TR R +V K+ K++ L P I E++
Sbjct: 903 CQDDCQLTSWSKFSSC---NGDCG---AVRTRKRTLVGKSKKKEKCKNSHLYPLI-ETQY 955
Query: 196 C 196
C
Sbjct: 956 C 956
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 39.3 bits (90), Expect = 0.003
Identities = 25/80 (31%), Positives = 33/80 (41%), Gaps = 16/80 (20%)
Query: 71 YGECLHS-------CPSGYY----GHRAPDMNRCAR---CRIENCDSCFSKDFCTKCKVG 116
YG C ++ CP G+ G D++ C C + C + C C G
Sbjct: 698 YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSG 757
Query: 117 FYLHRGRC--FDECPDGFAP 134
+LHRGRC DEC G P
Sbjct: 758 HHLHRGRCTDVDECSSGAPP 777
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 39.3 bits (90), Expect = 0.003
Identities = 25/80 (31%), Positives = 33/80 (41%), Gaps = 16/80 (20%)
Query: 71 YGECLHS-------CPSGYY----GHRAPDMNRCAR---CRIENCDSCFSKDFCTKCKVG 116
YG C ++ CP G+ G D++ C C + C + C C G
Sbjct: 728 YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSG 787
Query: 117 FYLHRGRC--FDECPDGFAP 134
+LHRGRC DEC G P
Sbjct: 788 HHLHRGRCTDVDECSSGAPP 807
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 39.3 bits (90), Expect = 0.003
Identities = 25/80 (31%), Positives = 33/80 (41%), Gaps = 16/80 (20%)
Query: 71 YGECLHS-------CPSGYY----GHRAPDMNRCAR---CRIENCDSCFSKDFCTKCKVG 116
YG C ++ CP G+ G D++ C C + C + C C G
Sbjct: 765 YGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSG 824
Query: 117 FYLHRGRC--FDECPDGFAP 134
+LHRGRC DEC G P
Sbjct: 825 HHLHRGRCTDVDECSSGAPP 844
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 38.9 bits (89), Expect = 0.004
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 101 CDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAP 134
C + S C C+ GF LH+ C CP GFAP
Sbjct: 587 CKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAP 620
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 38.5 bits (88), Expect = 0.005
Identities = 38/146 (26%), Positives = 50/146 (34%), Gaps = 30/146 (20%)
Query: 15 CMDYSHCQG-----NRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMR 69
C SHCQ + + R GC C C+ F
Sbjct: 204 CWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYF--------- 254
Query: 70 QYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECP 129
G CL +CP G Y + + RC E C S S F +H+G C +CP
Sbjct: 255 -QGACLWACPPGTYQYESW---RCVTA--ERCASLHSVPGRAST---FGIHQGSCLAQCP 305
Query: 130 DGFAPLEETMEC--VEG-----CEVG 148
GF ++ C EG C+VG
Sbjct: 306 SGFTRNSSSIFCHKCEGLCPKECKVG 331
>gi|33598931 scavenger receptor class F, member 1 isoform 3
precursor [Homo sapiens]
Length = 569
Score = 38.5 bits (88), Expect = 0.005
Identities = 54/223 (24%), Positives = 79/223 (35%), Gaps = 46/223 (20%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSR---CQQKLFFF-----LRREGMRQYG 72
C G WR+ + + PIC+G +C KD C + C+ K FF R G
Sbjct: 42 CAG--WRQKDQECTI--PICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGP 97
Query: 73 ECLHSCPSGYYGHRAPDMNRC--------ARCRIENC----DSCFSKDFCTKCKVGFYLH 120
+C SCP +G P C ARC C C+ G++
Sbjct: 98 DCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSS 157
Query: 121 RGRCFDECPDGFAPLEE-TMECVEGCEVGHWS---------EWGTCSRNNRTCGFK---W 167
R +C A E+ T CV C+ G W C +++ C + W
Sbjct: 158 TCRRPCQCNTAAARCEQATGACV--CKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWW 215
Query: 168 GLETRTR-QIVK---KPVKDTILCPTIAESRRCKMTMRHCPGG 206
G E + + + V+ CP RC++ CP G
Sbjct: 216 GPECQQQCECVRGRCSAASGECTCPPGFRGARCELP---CPAG 255
>gi|33598929 scavenger receptor class F, member 1 isoform 1
precursor [Homo sapiens]
Length = 830
Score = 38.5 bits (88), Expect = 0.005
Identities = 54/223 (24%), Positives = 79/223 (35%), Gaps = 46/223 (20%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSR---CQQKLFFF-----LRREGMRQYG 72
C G WR+ + + PIC+G +C KD C + C+ K FF R G
Sbjct: 42 CAG--WRQKDQECTI--PICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGP 97
Query: 73 ECLHSCPSGYYGHRAPDMNRC--------ARCRIENC----DSCFSKDFCTKCKVGFYLH 120
+C SCP +G P C ARC C C+ G++
Sbjct: 98 DCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSS 157
Query: 121 RGRCFDECPDGFAPLEE-TMECVEGCEVGHWS---------EWGTCSRNNRTCGFK---W 167
R +C A E+ T CV C+ G W C +++ C + W
Sbjct: 158 TCRRPCQCNTAAARCEQATGACV--CKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWW 215
Query: 168 GLETRTR-QIVK---KPVKDTILCPTIAESRRCKMTMRHCPGG 206
G E + + + V+ CP RC++ CP G
Sbjct: 216 GPECQQQCECVRGRCSAASGECTCPPGFRGARCELP---CPAG 255
>gi|145309306 scavenger receptor class F, member 1 isoform 5
precursor [Homo sapiens]
Length = 744
Score = 38.5 bits (88), Expect = 0.005
Identities = 54/223 (24%), Positives = 79/223 (35%), Gaps = 46/223 (20%)
Query: 21 CQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSR---CQQKLFFF-----LRREGMRQYG 72
C G WR+ + + PIC+G +C KD C + C+ K FF R G
Sbjct: 42 CAG--WRQKDQECTI--PICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGP 97
Query: 73 ECLHSCPSGYYGHRAPDMNRC--------ARCRIENC----DSCFSKDFCTKCKVGFYLH 120
+C SCP +G P C ARC C C+ G++
Sbjct: 98 DCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSS 157
Query: 121 RGRCFDECPDGFAPLEE-TMECVEGCEVGHWS---------EWGTCSRNNRTCGFK---W 167
R +C A E+ T CV C+ G W C +++ C + W
Sbjct: 158 TCRRPCQCNTAAARCEQATGACV--CKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWW 215
Query: 168 GLETRTR-QIVK---KPVKDTILCPTIAESRRCKMTMRHCPGG 206
G E + + + V+ CP RC++ CP G
Sbjct: 216 GPECQQQCECVRGRCSAASGECTCPPGFRGARCELP---CPAG 255
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.476
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,004,418
Number of Sequences: 37866
Number of extensions: 563792
Number of successful extensions: 3012
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 2644
Number of HSP's gapped (non-prelim): 362
length of query: 243
length of database: 18,247,518
effective HSP length: 99
effective length of query: 144
effective length of database: 14,498,784
effective search space: 2087824896
effective search space used: 2087824896
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.