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Search of human proteins with 222352164
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
(810 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 1786 0.0
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 1615 0.0
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 1047 0.0
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 1047 0.0
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens] 1047 0.0
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens] 1047 0.0
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 1046 0.0
gi|56237021 fibrillin 3 precursor [Homo sapiens] 162 9e-40
gi|66346695 fibrillin 2 precursor [Homo sapiens] 157 4e-38
gi|24430141 fibrillin 1 precursor [Homo sapiens] 155 1e-37
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 148 2e-35
gi|40807489 egf-like module containing, mucin-like, hormone rece... 145 1e-34
gi|118572606 hemicentin 1 [Homo sapiens] 144 4e-34
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 141 2e-33
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 139 1e-32
gi|148833508 notch1 preproprotein [Homo sapiens] 135 2e-31
gi|134244285 Notch homolog 3 [Homo sapiens] 135 2e-31
gi|34734066 fibulin 1 isoform D [Homo sapiens] 135 2e-31
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 135 2e-31
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 134 3e-31
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 133 8e-31
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 133 8e-31
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 133 8e-31
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 131 2e-30
gi|4557733 latent transforming growth factor beta binding protei... 131 3e-30
gi|19743803 fibulin 5 precursor [Homo sapiens] 130 4e-30
gi|110347437 latent transforming growth factor beta binding prot... 130 4e-30
gi|110347412 latent transforming growth factor beta binding prot... 130 4e-30
gi|110347431 latent transforming growth factor beta binding prot... 130 4e-30
gi|55770876 notch4 preproprotein [Homo sapiens] 129 1e-29
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 1786 bits (4626), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF
Sbjct: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
Query: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG
Sbjct: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
Query: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT
Sbjct: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
Query: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI
Sbjct: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
Query: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG
Sbjct: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
Query: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV
Sbjct: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
Query: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS
Sbjct: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
Query: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC
Sbjct: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
Query: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG
Sbjct: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
Query: 541 FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC
Sbjct: 541 FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
Query: 601 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 660
ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK
Sbjct: 601 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 660
Query: 661 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 720
DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE
Sbjct: 661 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 720
Query: 721 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 780
GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV
Sbjct: 721 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 780
Query: 781 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 810
WTMAGSPCTTCKCKNGRVCCSVDFECLQNN
Sbjct: 781 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 810
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 1615 bits (4181), Expect = 0.0
Identities = 747/810 (92%), Positives = 750/810 (92%), Gaps = 47/810 (5%)
Query: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF
Sbjct: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
Query: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG
Sbjct: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
Query: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT
Sbjct: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
Query: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI
Sbjct: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
Query: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG
Sbjct: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
Query: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV
Sbjct: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
Query: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS
Sbjct: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
Query: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC
Sbjct: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
Query: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG
Sbjct: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
Query: 541 FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
FTGSHCEKDIDEC+ C N S C+NL G + C C S
Sbjct: 541 FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPS--------------------- 579
Query: 601 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 660
GPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK
Sbjct: 580 --------------------------GPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 613
Query: 661 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 720
DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE
Sbjct: 614 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 673
Query: 721 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 780
GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV
Sbjct: 674 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 733
Query: 781 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 810
WTMAGSPCTTCKCKNGRVCCSVDFECLQNN
Sbjct: 734 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 763
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 1047 bits (2707), Expect = 0.0
Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 28 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 87
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 88 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 147
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 148 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 207
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 208 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 267
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 268 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 325
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 326 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 385
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 386 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 444
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 445 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 504
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 505 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 564
Query: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
CP GFTG CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC
Sbjct: 565 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 624
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 625 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 684
Query: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 685 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 744
Query: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 745 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 804
Query: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 805 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 837
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 1047 bits (2707), Expect = 0.0
Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
Query: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
CP GFTG CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC
Sbjct: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
Query: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
Query: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
Query: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
Length = 866
Score = 1047 bits (2707), Expect = 0.0
Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 55 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 114
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 115 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 174
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 175 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 234
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 235 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 294
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 295 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 352
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 353 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 412
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 413 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 471
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 472 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 531
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 532 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 591
Query: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
CP GFTG CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC
Sbjct: 592 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 651
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 652 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 711
Query: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 712 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 771
Query: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 772 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 831
Query: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 832 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 864
>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 1047 bits (2707), Expect = 0.0
Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
Query: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
CP GFTG CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC
Sbjct: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
Query: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
Query: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
Query: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 1046 bits (2705), Expect = 0.0
Identities = 449/800 (56%), Positives = 581/800 (72%), Gaps = 12/800 (1%)
Query: 18 TVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKL 77
+V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD R I A+ +E+
Sbjct: 17 SVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 76
Query: 78 IQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNG-KPR 136
Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E+R HY +P
Sbjct: 77 FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 136
Query: 137 TEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQK 196
TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP G WLGQRN
Sbjct: 137 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 196
Query: 197 HGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNY 256
HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+LQ++LAK +AKL+
Sbjct: 197 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 256
Query: 257 AETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSP 316
AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++C + CP +C
Sbjct: 257 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQCETLICPNPDCPL 314
Query: 317 DSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECRGGVLVKITEM--C 368
S ++ G+CCK C+ C + G+ EG+R S EC+ + K+ E C
Sbjct: 315 KSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTM-KLVESSGC 373
Query: 369 PPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGD 428
P L+C E I + CC+VC+G++FC+E C ENS C+N N +A C C+ G+ +++ D
Sbjct: 374 PALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED 433
Query: 429 SAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCD 488
+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCTEHDEC + QHNCD
Sbjct: 434 NAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 493
Query: 489 ENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEK 548
ENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C CP GFTG CE
Sbjct: 494 ENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET 553
Query: 549 DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCW 608
DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC DIDEC H+C
Sbjct: 554 DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 613
Query: 609 NDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRR 668
ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCSVCSC++G + CRR
Sbjct: 614 NDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 673
Query: 669 TACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL 728
CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQCRCL+GEVDCWPL
Sbjct: 674 MVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 733
Query: 729 TCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPC 788
CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R +GS W G+ C
Sbjct: 734 PCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTEC 793
Query: 789 TTCKCKNGRVCCSVDFECLQ 808
T C+CKNG +CCSVD +CLQ
Sbjct: 794 TLCQCKNGHICCSVDPQCLQ 813
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 162 bits (411), Expect = 9e-40
Identities = 181/658 (27%), Positives = 256/658 (38%), Gaps = 150/658 (22%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN-CS 315
E+ ++NC C LL R + + D C C G + + +C ++ CS
Sbjct: 1060 ESGFMLMKNCMDVDECARDPLLCRG-GTCTNTDGSYKCQCPPGHELTAKGTACEDIDECS 1118
Query: 316 -PDSLPVHIAGQCCKVC---RPKCIYGGKVLAEGQRILT-KSCRECRGGVLVKI--TEMC 368
D L H GQC V + C G + + Q + CR GG V TE
Sbjct: 1119 LSDGLCPH--GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
Query: 369 PPLNCSEKDHILPENQCC----------RVC-RGH----------------------NFC 395
+C + ++P+ + C RVC +GH C
Sbjct: 1177 YRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
Query: 396 AEGPKCGEN------SECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANT 449
+ +C N +C+N C C+ GY+ +G + C D+DEC H C ++
Sbjct: 1237 VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATG-CSDVDECEVGGHNCDSHA 1295
Query: 450 VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
C+N+PG + C C+PG++ D F C + DEC S +H C C N + CTC+ G+
Sbjct: 1296 SCLNIPGSFSCRCLPGWVG-DGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA 1354
Query: 510 GNGTIC--RAFCEEG---CRYGGTCVAPN--KCVCPSGF--TGSH--CEKDIDECSEGII 558
G+G C R C E C G AP +C C GF T H C+ D+DEC++G +
Sbjct: 1355 GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ-DVDECAQGNL 1413
Query: 559 ECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAG 618
C S C NLPG + C C G+ D G +C DI+ECA + C N CIN G
Sbjct: 1414 -CAFGS-CENLPGMFRCICNGGYELD----RGGGNCTDINECADPVN-CIN-GVCINTPG 1465
Query: 619 GFDCLC-------PSGPSC----SGDCPHEGGLKHNGQVWTLKEDRCSV----CSCKDGK 663
+ C C PSG C +G+C E + + + E V C C G+
Sbjct: 1466 SYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGR 1525
Query: 664 IFCRR-TACDCQNPSADLFCCPECD----TRVT------SQCLDQNGHKLYRSGDNW-TH 711
+ C N + CP + R+T +C + G L + GD T
Sbjct: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPG--LCQGGDCVNTF 1583
Query: 712 SCQQCRCLEG-----------EVD--------CWPLTCPNLSCEYTAILEGE-------- 744
QC C G ++D C P TC N YT + E
Sbjct: 1584 GSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGN 1643
Query: 745 --------CCPRCVSDPC---LADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC 791
C R + C LA N+T RK C SY + G W PC C
Sbjct: 1644 NCMDMRKSVCFRHYNGTCQNELAFNVT---RKMCCCSYNI----GQAW---NRPCEAC 1691
Score = 136 bits (342), Expect = 9e-32
Identities = 128/440 (29%), Positives = 173/440 (39%), Gaps = 96/440 (21%)
Query: 259 TRLSQLENCHCEKTCQVSGLLYRDQDSWVDGD---HCRNCTCKS--GAVECRRMSCPPLN 313
T S L C T + G + RD D DG H R CK+ G C
Sbjct: 2184 TEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV-------- 2235
Query: 314 CSPDSLPVHIAGQCC---KVCRPK---CIYGGKVLAEGQ------------RILTKSCRE 355
C P P+ +G+ C C + C+ G V G LT+ C +
Sbjct: 2236 CPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTE-CHD 2294
Query: 356 CRGGVLVK--ITEMCPPLNCSEKDHILPENQC---------CRVC-------------RG 391
R G + MC L+ S + E C C +C G
Sbjct: 2295 IRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG 2354
Query: 392 HNFCAEGPKCGE---------NSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKM 442
+ AEG E + EC N C C++GY + + C D+DEC+
Sbjct: 2355 SGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGY-TPDATATTCLDMDECSQVP 2413
Query: 443 HYCHANTVCVNLPGLYRCDCVPGYIRVDDF-SCTEHDECGSGQHNCDENAICTNTVQGHS 501
C +C N G + C C GY+ +D +C + DEC S QHNC +C NTV +
Sbjct: 2414 KPC--TFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFT 2469
Query: 502 CTCKPGYVGNGTICRAFCEEGCR-YGGTCVAPN---------KCVCPSGFT----GSHCE 547
C C PG+ + C F + C G C A +C C GFT G CE
Sbjct: 2470 CRCPPGFTQHHQAC--FDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
Query: 548 KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTC 607
D++EC +G C + C N G Y C C GF ++ C+D +ECAL TC
Sbjct: 2528 -DVNEC-DGPHRCQHG--CQNQLGGYRCSCPQGFTQHSQWA----QCVDENECALSPPTC 2579
Query: 608 WNDSACINLAGGFDCLCPSG 627
++C N GGF C+CPSG
Sbjct: 2580 -GSASCRNTLGGFRCVCPSG 2598
Score = 134 bits (336), Expect = 4e-31
Identities = 89/320 (27%), Positives = 129/320 (40%), Gaps = 45/320 (14%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C E P N C N CEC +G+ + CED+DEC ++ C N C+N+
Sbjct: 1725 CGEIPAICANGICINQIGSFRCECPAGF-NYNSILLACEDVDECGSRESPCQQNADCINI 1783
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG-- 512
PG YRC C GY +C +EC + C + C +T + C C G+ +
Sbjct: 1784 PGSYRCKCTRGYKLSPGGACVGRNECREIPNVC-SHGDCMDTEGSYMCLCHRGFQASADQ 1842
Query: 513 TICRAF--CEEGCRYGGTC---VAPNKCVCPSGFTGSH---CEKDIDECSEGIIECHNHS 564
T+C C+ GTC + C+C GF +H C D DEC+ + +
Sbjct: 1843 TLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFG 1901
Query: 565 RCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLC 624
C+N G +HC C+ GF + G++C+D +EC TC C NL G F C+C
Sbjct: 1902 HCLNTAGSFHCLCQDGFE----LTADGKNCVDTNECLSLAGTCL-PGTCQNLEGSFRCIC 1956
Query: 625 PSGPSCSGDCPHEGGLKHNGQVWTLKEDRC-SVCSCKDGKIFCRRTACDCQNPSADLFCC 683
P G + ++ D C + C + C C S C
Sbjct: 1957 PPG-------------------FQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCP 1997
Query: 684 PECDTRVTSQCLDQNGHKLY 703
P L NGH+ +
Sbjct: 1998 P-------GFVLSDNGHRCF 2010
Score = 127 bits (320), Expect = 3e-29
Identities = 110/373 (29%), Positives = 157/373 (42%), Gaps = 60/373 (16%)
Query: 325 GQCCKVC--------RPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNC--- 373
G C++C R C +G AEG+ + ECR + +C C
Sbjct: 2333 GPRCELCPLPGTSAYRKLCPHGSGYTAEGRDV-----DECR-----MLAHLCAHGECINS 2382
Query: 374 --SEKDHI---LPENQCCRVCRGHNFCAEGPK-CGENSECKNWNTKATCECKSGYISVQG 427
S + H + C + C++ PK C CKN C C GY+ ++
Sbjct: 2383 LGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFLCSCPRGYL-LEE 2439
Query: 428 DSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNC 487
D C+D+DEC ++ H C +CVN G + C C PG+ + +C ++DEC + C
Sbjct: 2440 DGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQ-ACFDNDECSAQPGPC 2496
Query: 488 DENAICTNTVQGHSCTCKPGY--VGNGTICRAF--------CEEGCRYGGTCVAPNKCVC 537
+ C NT C C G+ V +G C C+ GC+ + +C C
Sbjct: 2497 GAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQ---NQLGGYRCSC 2553
Query: 538 PSGFTGSHCE----KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGES 593
P GFT H + D +EC+ C + S C N G + C C SGF D +L G
Sbjct: 2554 PQGFT-QHSQWAQCVDENECALSPPTCGSAS-CRNTLGGFRCVCPSGFDFD--QALGG-- 2607
Query: 594 CIDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSCSGDCPHEGGLKHNGQVWTLKE 651
C ++DECA R C +C N GGF C CP G + G C G Q KE
Sbjct: 2608 CQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKE 2665
Query: 652 DRCSVCSCKDGKI 664
+ S +C + KI
Sbjct: 2666 ELLSSEACYECKI 2678
Score = 126 bits (316), Expect = 9e-29
Identities = 130/463 (28%), Positives = 172/463 (37%), Gaps = 83/463 (17%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C P + C+N C C G+ ++ C DIDEC C T CV
Sbjct: 988 NECKVFPGLCTHGTCRNTVGSFHCACAGGF-ALDAQERNCTDIDECRISPDLCGQGT-CV 1045
Query: 453 NLPGLYRCDCVPGYIRVDDF----SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
N PG + C+C PGY F +C + DEC C CTNT + C C PG+
Sbjct: 1046 NTPGSFECECFPGY--ESGFMLMKNCMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGH 1102
Query: 509 --VGNGTICRAFCE----EGCRYGGTCV---APNKCVCPSGFTGSHCEK---DIDECSEG 556
GT C E +G G CV +C C +GF + + DI+EC
Sbjct: 1103 ELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQ 1162
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSL--SGESCIDIDECALRTHTCWNDSACI 614
C H C+N G Y C C G YSL G +C D+DEC C + C
Sbjct: 1163 NGGCDVH--CINTEGSYRCSCGQG------YSLMPDGRACADVDECEENPRVC-DQGHCT 1213
Query: 615 NLAGGFDCLCPSGPSCSGD---------CPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIF 665
N+ GG CLC G + D C + +G K VC C+ G
Sbjct: 1214 NMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS--FVCHCQLG-YM 1270
Query: 666 CRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC----RCLEG 721
R+ A C + CD+ + CL+ G R W +C C+
Sbjct: 1271 VRKGATGCSDVDECEVGGHNCDSH--ASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQ 1328
Query: 722 EVDCWPL-TCPNL------SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVS 774
E C P C N+ +C +G C D C A+N+ CL++ G
Sbjct: 1329 EHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCED--RDEC-AENVDLCDNGQCLNAPGGY 1385
Query: 775 RLSGSVWTMAGSPCTTCKCKNG-------RVCCSVDFECLQNN 810
R C+C+ G R C VD EC Q N
Sbjct: 1386 R---------------CECEMGFDPTEDHRACQDVD-ECAQGN 1412
Score = 113 bits (282), Expect = 8e-25
Identities = 125/479 (26%), Positives = 175/479 (36%), Gaps = 111/479 (23%)
Query: 371 LNCSEKD-----HILPENQCCRVCRGHNF-CAEG------------PKCGENS-----EC 407
+NC + D H + C V G CA+G +C N C
Sbjct: 2122 INCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRC 2181
Query: 408 KNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTV-CVNLPGLYRCDCVPGY 466
N C C +GY +++ D A C D+DECA CHA + C NL G + C C PG
Sbjct: 2182 HNTEGSYLCTCPAGY-TLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGM 2240
Query: 467 --IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY-----------VGNG- 512
+ CT+ +EC + C N C NT C C G+ + G
Sbjct: 2241 RPLPGSGEGCTDDNECHAQPDLC-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Query: 513 -------TICRAFCE--------EGCRYGGTCVAPNKCVCP--------------SGFTG 543
T+CR+ E C GG P +CP SG+T
Sbjct: 2300 CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTA 2359
Query: 544 SHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALR 603
+D+DEC C H C+N G + C C++G+ D T +C+D+DEC+
Sbjct: 2360 E--GRDVDECRMLAHLC-AHGECINSLGSFRCHCQAGYTPDAT----ATTCLDMDECSQV 2412
Query: 604 THTCWNDSACINLAGGFDCLCP-------SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
C C N G F C CP G +C D +HN Q +
Sbjct: 2413 PKPC--TFLCKNTKGSFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFT 2469
Query: 657 CSCKDGKIFCRRTACDCQNPSADLFCC---PEC-DTRVTSQCLDQNGHKLYRSGDNWTHS 712
C C G + D SA C C +T + +C G L SG H
Sbjct: 2470 CRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSG----HG 2525
Query: 713 CQ---QC----RCLEG---EVDCWPLTCPNLSCEYT----AILEGECC---PRCVSDPC 754
C+ +C RC G ++ + +CP +++ + E EC P C S C
Sbjct: 2526 CEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
Score = 111 bits (278), Expect = 2e-24
Identities = 147/551 (26%), Positives = 195/551 (35%), Gaps = 115/551 (20%)
Query: 287 VDGDHCRNCTCKSGAVECRRM-SCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEG 345
+D D C + C G +C + C P C V +CI G + G
Sbjct: 448 IDVDECTSSPCHHG--DCVNIPGTYHCRCYPGFQATPTRQACVDV--DECIVSGGLCHLG 503
Query: 346 QRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENS 405
+ + T+ +C C+ + P+ + C HN CA C N
Sbjct: 504 RCVNTEGSFQCV---------------CNAGFELSPDG---KNCVDHNECATSTMC-VNG 544
Query: 406 ECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 465
C N + +C CK G++ G YC DIDEC C N C N G +RC C+ G
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGH-YCMDIDECQTP-GIC-VNGHCTNTEGSFRCQCLGG 601
Query: 466 Y-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCK-PGYVGNGTICRAFCEEGC 523
+ D C + + C ++ SC PG V C A + G
Sbjct: 602 LAVGTDGRVCVD----------THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG- 650
Query: 524 RYGGTC-VAPNK------CVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCE 576
+G C + P K +C SG + +DI+EC+ C N C NL G Y C
Sbjct: 651 -FGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCAN-GVCENLRGSYRCV 708
Query: 577 CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
C G+ SG+ C D+DECAL + C N C N G + C CP G
Sbjct: 709 CNLGYEAGA----SGKDCTDVDECALNSLLCDN-GWCQNSPGSYSCSCPPG--------- 754
Query: 637 EGGLKHNGQVWTLKE-----DRCSVCSCKDGKIFCRRTA----CDCQNPSADLFCCPECD 687
W E D C C G CR A C C P + L D
Sbjct: 755 -------FHFWQDTEICKDVDECLSSPCVSG--VCRNLAGSYTCKC-GPGSRL------D 798
Query: 688 TRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCP 747
T CLD G W Q+ RC EV+ + + C G C
Sbjct: 799 PSGTF-CLDST------KGTCWL-KIQESRC---EVNLQGASLRSECCATLGAAWGSPCE 847
Query: 748 RCVSDPCLA------DNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKC-------K 794
RC DP A +T D C GV +G AGS C+C
Sbjct: 848 RCEIDPACARGFARMTGVTCDDVNECESFPGVCP-NGRCVNTAGS--FRCECPEGLMLDA 904
Query: 795 NGRVCCSVDFE 805
+GR+C V E
Sbjct: 905 SGRLCVDVRLE 915
Score = 108 bits (271), Expect = 2e-23
Identities = 116/422 (27%), Positives = 148/422 (35%), Gaps = 114/422 (27%)
Query: 433 EDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENA 491
EDIDEC C CVN G ++C+C PGY + C + DEC + C
Sbjct: 1562 EDIDECQELPGLCQGGD-CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1620
Query: 492 ICTNTVQGHSCTCKPGY--VGNGTICRAFCEEGC--RYGGTC-------VAPNKCVC--- 537
C NT+ ++C C Y V G C + C Y GTC V C C
Sbjct: 1621 -CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYN 1679
Query: 538 ----------------------------PSGFTGSHCEK--DIDECSEGIIECHNHSRCV 567
P T H K DIDEC E C N C+
Sbjct: 1680 IGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICAN-GICI 1738
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
N G + CEC +GF+ Y+ +C D+DEC R C ++ CIN+ G + C C G
Sbjct: 1739 NQIGSFRCECPAGFN----YNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRG 1794
Query: 628 PSCS--------------------GDCPHEGG----LKHNG------QVWTLKEDRCSVC 657
S GDC G L H G Q + D C
Sbjct: 1795 YKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ 1854
Query: 658 SCKDG--KIFCRRTACDC-----QNPSADLFCCPECDTRV--------------TSQCLD 696
C +G K C C + D EC T V + CL
Sbjct: 1855 PCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLC 1914
Query: 697 QNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCP---RCVSDP 753
Q+G +L G N + +C L G C P TC NL + I CP + SD
Sbjct: 1915 QDGFELTADGKNCVDT-NECLSLAG--TCLPGTCQNLEGSFRCI-----CPPGFQVQSDH 1966
Query: 754 CL 755
C+
Sbjct: 1967 CI 1968
Score = 105 bits (262), Expect = 2e-22
Identities = 75/238 (31%), Positives = 94/238 (39%), Gaps = 44/238 (18%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N CAE P N C N + CEC GY S+ C D DEC+ H C T C
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGY-SLDFTGINCVDTDECSVG-HPCGQGT-CT 2142
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--G 510
N+ G + C C G+ +C + DEC C C NT + CTC GY
Sbjct: 2143 NVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCTCPAGYTLRE 2200
Query: 511 NGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHS-RCVNL 569
+G +CR D+DEC++G +CH C NL
Sbjct: 2201 DGAMCR--------------------------------DVDECADGQQDCHARGMECKNL 2228
Query: 570 PGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
G + C C G SGE C D +EC + C N C+N AG F C C G
Sbjct: 2229 IGTFACVCPPGMR---PLPGSGEGCTDDNECHAQPDLCVN-GRCVNTAGSFRCDCDEG 2282
Score = 104 bits (260), Expect = 3e-22
Identities = 105/396 (26%), Positives = 143/396 (36%), Gaps = 52/396 (13%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C G N C E P + +C + C C G+ D C DIDEC + C N
Sbjct: 1803 CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGF-QASADQTLCMDIDECDRQP--C-GN 1858
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C N+ G Y C C PG++ + C + DEC + C NT C C+ G+
Sbjct: 1859 GTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGF 1918
Query: 509 --VGNGTICRAFCEEGCRYGGTCVAPN--------KCVCPSGF--TGSHCEKDIDECSEG 556
+G C E GTC+ +C+CP GF HC DIDECSE
Sbjct: 1919 ELTADGKNC-VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHC-IDIDECSEE 1976
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINL 616
C C N PG + C C GF S +G C D + T ++ ++
Sbjct: 1977 PNLC-LFGTCTNSPGSFQCLCPPGF----VLSDNGHRCFDTRQSFCFTRF---EAGKCSV 2028
Query: 617 AGGFD-----CLCPSGPSCS-GD----CPHEGGLKH-------NGQVWTLKEDRCSVCSC 659
F+ C C P GD CP EG +G V + R V C
Sbjct: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNEC 2088
Query: 660 KDGKIFCRRTACDCQNPSADLFCCPECDTRVTS-QCLDQN----GHKLYRSGDNWTHSCQ 714
+ C C + S C T C+D + GH +
Sbjct: 2089 AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGF 2148
Query: 715 QCRCLEGEVDCWPLTCPNL-SCEYTAILEGECCPRC 749
+C C +G +TC ++ C +L C RC
Sbjct: 2149 ECACADGFEPGLMMTCEDIDECSLNPLL---CAFRC 2181
Score = 85.9 bits (211), Expect = 1e-16
Identities = 60/197 (30%), Positives = 79/197 (40%), Gaps = 49/197 (24%)
Query: 460 CDCVPGYIRVDDFSCTEHDECG-SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G T CG S C + + T +G SC C+ GY G T+C +
Sbjct: 101 CTCADG---------TLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTG--TVCGQP 149
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDI-----------DECSEGI--------I 558
C+ GC GG C+ PN+C C GF G CE+D + C + +
Sbjct: 150 ICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKAL 209
Query: 559 ECHNHSRCVNLPGWYHCE--------CRSGFHDDGTYSLSGESCIDIDECALRTHTCWND 610
C R LP CE CR GF ++ +C D+DEC C
Sbjct: 210 CCATVGRAWGLP----CELCPAQPHPCRRGF----IPNIHTGACQDVDECQAVPGLCQGG 261
Query: 611 SACINLAGGFDCLCPSG 627
S C+N+ G F C CP G
Sbjct: 262 S-CVNMVGSFHCRCPVG 277
Score = 85.1 bits (209), Expect = 2e-16
Identities = 141/566 (24%), Positives = 200/566 (35%), Gaps = 104/566 (18%)
Query: 294 NCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKS- 352
+C G+ CR L+ S + + AG C V ++GG+ + T+
Sbjct: 262 SCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSV-----LFGGRCAGDLAGHYTRRQ 316
Query: 353 --CRECRGGVLVKITEMCPPLN-------CSEKDHILPENQ-CCRVCRGHNFCAEGPKCG 402
C R + E+CPP C+++ +LP + G GP G
Sbjct: 317 CCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLG 376
Query: 403 ENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
+ + S G + + ID C + C N C+ P YRC+C
Sbjct: 377 PARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLC-LNGRCLPTPSSYRCEC 435
Query: 463 VPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGT------IC 515
GY + C + DEC S H+ D C N + C C PG+ T +
Sbjct: 436 NVGYTQDVRGECIDVDECTSSPCHHGD----CVNIPGTYHCRCYPGFQATPTRQACVDVD 491
Query: 516 RAFCEEGCRYGGTCVAPN---KCVCPSGF----TGSHCEKDIDECSEGIIECHNHSRCVN 568
G + G CV +CVC +GF G +C D +EC+ + C N C+N
Sbjct: 492 ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTM-CVN-GVCLN 548
Query: 569 LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 628
G + C C+ GF + G C+DIDEC +T + C N G F C C G
Sbjct: 549 EDGSFSCLCKPGF----LLAPGGHYCMDIDEC--QTPGICVNGHCTNTEGSFRCQCLGGL 602
Query: 629 SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRR--------TACDCQNP---- 676
+ D G+V R S C K C R + C C NP
Sbjct: 603 AVGTD----------GRVCVDTHVR-STCYGAIEKGSCARPFPGTVTKSECCCANPDHGF 651
Query: 677 SADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCE 736
CP D+ Q L +G + G +C L+ EV C C NL
Sbjct: 652 GEPCQLCPAKDS-AEFQALCSSGLGITTDG----RDINEC-ALDPEV-CANGVCENLRGS 704
Query: 737 YTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGV------SRLSGSVWTMAGSPCTT 790
Y RCV N+ Y+ + D V S L + W +
Sbjct: 705 Y----------RCVC------NLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS 748
Query: 791 CKCKNG-------RVCCSVDFECLQN 809
C C G +C VD ECL +
Sbjct: 749 CSCPPGFHFWQDTEICKDVD-ECLSS 773
Score = 55.1 bits (131), Expect = 3e-07
Identities = 58/228 (25%), Positives = 79/228 (34%), Gaps = 34/228 (14%)
Query: 272 TCQVSGLLYRDQDSWVDGDHCRN--------CTCKSGAVECRRMSCPPL----------- 312
+C LL D + D D C + C GA CR CPP
Sbjct: 2430 SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCR---CPPGFTQHHQACFDN 2486
Query: 313 -NCSPDSLPVHIAGQCCKV---CRPKCIYGGKVLAEGQRILTKSCRECRGGVLVK--ITE 366
CS P G C R +C G +++ G + EC G +
Sbjct: 2487 DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC--EDVNECDGPHRCQHGCQN 2544
Query: 367 MCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQ 426
CS +Q + C N CA P ++ C+N C C SG+ Q
Sbjct: 2545 QLGGYRCSCPQGFTQHSQWAQ-CVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQ 2603
Query: 427 GDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSC 474
C+++DECA + C + C N PG + C C GY R C
Sbjct: 2604 ALGG-CQEVDECAGRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGHC 2648
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/94 (29%), Positives = 39/94 (41%), Gaps = 7/94 (7%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH 477
C+ G+I A C+D+DEC A C + CVN+ G + C C G+ R+ D S
Sbjct: 232 CRRGFIPNIHTGA-CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGH-RLSDSSAACE 288
Query: 478 DECGSGQHNCDENAICTNTVQGH----SCTCKPG 507
D + C + GH C C G
Sbjct: 289 DYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
Score = 36.2 bits (82), Expect = 0.13
Identities = 34/123 (27%), Positives = 41/123 (33%), Gaps = 29/123 (23%)
Query: 514 ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWY 573
ICR C EG C PN C C G C + S + C N C
Sbjct: 85 ICRRACGEGF-----CSQPNLCTCADGTLAPSC--GVSRGSGCSVSCMNGGTCRGA---- 133
Query: 574 HCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP---SGPSC 630
C C+ G+ T ++ G+ D C N CI G C C GP C
Sbjct: 134 SCLCQKGY----TGTVCGQPICD--------RGCHNGGRCI---GPNRCACVYGFMGPQC 178
Query: 631 SGD 633
D
Sbjct: 179 ERD 181
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 157 bits (397), Expect = 4e-38
Identities = 116/387 (29%), Positives = 167/387 (43%), Gaps = 30/387 (7%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLNCSP 316
E+ ++NC C+ + LL R + V+ + C C G + R C +N
Sbjct: 1147 ESGFMMMKNCMDIDECERNPLLCRG-GTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
Query: 317 DSLPVHIAGQCCKVC---RPKCIYGGKVLAEGQRILT-KSCRECRGGVLVKIT--EMCPP 370
S + G+C + + C G + + Q C GG + T E
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
Query: 371 LNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSA 430
+CSE ++P+ R C + C P + +C N + C C G+++ D
Sbjct: 1266 CSCSEGYALMPDG---RSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM-DMK 1321
Query: 431 YCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDE 489
C D++EC + C C N G + C C GY ++ CT+ DEC G HNCD
Sbjct: 1322 TCIDVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM 1380
Query: 490 NAICTNTVQGHSCTCKPGYVGNGTICRAF--CEEG---CRYGGTCV---APNKCVCPSGF 541
+A C N C+C+ G++GNG C C G C CV +C C GF
Sbjct: 1381 HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440
Query: 542 TGSHCE-KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
TG D+DEC+E I C N +C+N+PG Y CEC GF T + SC DIDEC
Sbjct: 1441 TGDGFTCSDVDECAENINLCEN-GQCLNVPGAYRCECEMGF----TPASDSRSCQDIDEC 1495
Query: 601 ALRTHTCWNDSACINLAGGFDCLCPSG 627
+ + + C NL G F C+C G
Sbjct: 1496 SFQNICVF--GTCNNLPGMFHCICDDG 1520
Score = 130 bits (327), Expect = 5e-30
Identities = 79/242 (32%), Positives = 111/242 (45%), Gaps = 16/242 (6%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C E P N C N CEC +G+ S CEDIDEC+ + C N C+N
Sbjct: 1812 CKEIPGICANGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCINS 1870
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG--NG 512
PG YRC+C G+ + +C + +EC + C + +C + + C C G+ +
Sbjct: 1871 PGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQ 1929
Query: 513 TICRAF--CEEGCRYGGTC---VAPNKCVCPSGFTGSHCEK--DIDECSEGIIECHNHSR 565
T+C CE GTC V C+C GF +H DIDECS + + R
Sbjct: 1930 TMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGR 1989
Query: 566 CVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP 625
C N G + C C G+ + G++CID +EC +C + C NL G F C+CP
Sbjct: 1990 CFNEIGSFKCLCNEGYE----LTPDGKNCIDTNECVALPGSC-SPGTCQNLEGSFRCICP 2044
Query: 626 SG 627
G
Sbjct: 2045 PG 2046
Score = 125 bits (314), Expect = 2e-28
Identities = 91/291 (31%), Positives = 130/291 (44%), Gaps = 39/291 (13%)
Query: 395 CAEGPK-CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C++ PK C N CKN C C GY+ +Q D C+D+DEC K H C +CVN
Sbjct: 2495 CSQSPKPC--NYICKNTEGSYQCSCPRGYV-LQEDGKTCKDLDECQTKQHNCQF--LCVN 2549
Query: 454 LPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--GN 511
G + C C PG+ + +C +++ECGS C IC NT SC C+ G+
Sbjct: 2550 TLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT 2608
Query: 512 GTICRAF--------CEEGCRYGGTCVAPNKCVCPSG----FTGSHCEKDIDECSEGIIE 559
G C C+ GC+ + +C CP G + + C D +ECS
Sbjct: 2609 GLNCEDVDECDGNHRCQHGCQ---NILGGYRCGCPQGYIQHYQWNQC-VDENECSNP--N 2662
Query: 560 CHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGG 619
+ C N G Y C C SGF ++ +C D++EC+ + C + C N GG
Sbjct: 2663 ACGSASCYNTLGSYKCACPSGF----SFDQFSSACHDVNECSSSKNPC--NYGCSNTEGG 2716
Query: 620 FDCLCPSGPSCSGDCPHEGGLKHN-GQVWTL-----KEDRCSVCSCKDGKI 664
+ C CP G G G+ N GQ +L +E+ S +C + KI
Sbjct: 2717 YLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKI 2767
Score = 116 bits (290), Expect = 1e-25
Identities = 127/472 (26%), Positives = 172/472 (36%), Gaps = 112/472 (23%)
Query: 392 HNFCAEGPKCGE-------NSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHY 444
+N C + +C N C N C C GY + D C D +EC A
Sbjct: 1968 NNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY-ELTPDGKNCIDTNECVALPGS 2026
Query: 445 CHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTC 504
C T C NL G +RC C PGY V +C + +EC + C + CTNT G C C
Sbjct: 2027 CSPGT-CQNLEGSFRCICPPGY-EVKSENCIDINECDEDPNICLFGS-CTNTPGGFQCLC 2083
Query: 505 KPGYV--GNGTIC----RAFCEEGCRYGGTCVAPN-------KCVC---PSGFTGSHCE- 547
PG+V NG C ++FC G C P KC C P G CE
Sbjct: 2084 PPGFVLSDNGRRCFDTRQSFCFTNFE-NGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCEL 2142
Query: 548 ---------------------------KDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
+D++EC E C N +C+N G + CEC G
Sbjct: 2143 CPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSN-GQCINTDGSFRCECPMG 2201
Query: 581 FHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGL 640
++ D T G C+D DEC++ + C N + C N+ G F+C C G E G
Sbjct: 2202 YNLDYT----GVRCVDTDECSIG-NPCGNGT-CTNVIGSFECNCNEG--------FEPGP 2247
Query: 641 KHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFC-CPECDTRVTSQCLDQNG 699
N + + C + C A C N C CP L ++
Sbjct: 2248 MMNCE---------DINECAQNPLLC---AFRCMNTFGSYECTCP------IGYALRED- 2288
Query: 700 HKLYRSGDNWTHSCQQCRCLEGEVDCWP--LTCPNLSCEYTAILEGECCPRCVSDPCLAD 757
K+ + D C EG DC + C NL + I R + C+ +
Sbjct: 2289 QKMCKDLDE---------CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339
Query: 758 NITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQN 809
N C G+ +G + GS C+C G S ECL N
Sbjct: 2340 N-------ECRTKPGICE-NGRCVNIIGS--YRCECNEGFQSSSSGTECLDN 2381
Score = 115 bits (287), Expect = 2e-25
Identities = 104/352 (29%), Positives = 133/352 (37%), Gaps = 79/352 (22%)
Query: 390 RGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANT 449
R N CA P N C+N C C SGY C DIDEC C N
Sbjct: 767 RDINECALDPDICANGICENLRGSYRCNCNSGY-EPDASGRNCIDIDECLVNRLLCD-NG 824
Query: 450 VCVNLPGLYRCDCVPGYI-RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG- 507
+C N PG Y C C PGY+ R + +C + +EC S N N C N + +C C PG
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES---NPCVNGACRNNLGSFNCECSPGS 881
Query: 508 -YVGNGTIC-------------RAFCEE---------------GCRYGGTCVAPNKC--- 535
G IC + CE G +G C +C
Sbjct: 882 KLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC---ERCELD 938
Query: 536 -VCPSGFT---GSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSG 591
CP G G CE D++EC C N RCVN G +HCEC G DGT G
Sbjct: 939 TACPRGLARIKGVTCE-DVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGT----G 992
Query: 592 ESCIDI--DECALRTHTCWNDSACIN-LAGGF---DCLCPSGPSCSGD------------ 633
C+DI ++C L+ W++ CI+ + G F C C G + +
Sbjct: 993 RVCLDIRMEQCYLK----WDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEY 1048
Query: 634 ---CPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFC 682
CP G + G V T + + CK C T C+N C
Sbjct: 1049 ETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC--TYGKCRNTIGSFKC 1098
Score = 111 bits (278), Expect = 2e-24
Identities = 113/426 (26%), Positives = 159/426 (37%), Gaps = 84/426 (19%)
Query: 387 RVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCH 446
+ C + C + +N C N + C C +G+ + D C D DEC + C
Sbjct: 571 QACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGF-ELTTDGKNCVDHDECTT-TNMC- 627
Query: 447 ANTVCVNLPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAICTNTVQGHSCTCK 505
N +C+N G ++C C PG++ + CT+ DEC + N C N+ C C
Sbjct: 628 LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRCDCP 685
Query: 506 PGY-VG-NGTIC-----RAFCEEGCRYGGTCVAP-------NKCVC--PSGFTGSHCE-- 547
PG VG +G +C R+ C G + G CV P ++C C P G C+
Sbjct: 686 PGLAVGMDGRVCVDTHMRSTCYGGIK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPC 744
Query: 548 ----------------------KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDG 585
+DI+EC+ C N C NL G Y C C SG+ D
Sbjct: 745 PAKNSAEFHGLCSSGVGITVDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDA 803
Query: 586 TYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQ 645
SG +CIDIDEC + C ++ C N G + C CP G
Sbjct: 804 ----SGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCTCPP-----------------GY 841
Query: 646 VWTLKEDRC-SVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQ-CLDQNGHKLY 703
V+ + + C + C+ C AC S + C P T C+D
Sbjct: 842 VFRTETETCEDINECESNP--CVNGACRNNLGSFNCECSPGSKLSSTGLICIDS------ 893
Query: 704 RSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDI 763
G W + Q RC EV+ T + C G C RC D +
Sbjct: 894 LKGTCWL-NIQDSRC---EVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIK 949
Query: 764 RKTCLD 769
TC D
Sbjct: 950 GVTCED 955
Score = 105 bits (263), Expect = 1e-22
Identities = 83/272 (30%), Positives = 113/272 (41%), Gaps = 32/272 (11%)
Query: 380 LPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQG-----DSAYCED 434
LP N R+C C N C+ T T + K+ ++ G + D
Sbjct: 1753 LPFNVTKRMC----CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808
Query: 435 IDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAIC 493
IDEC C AN VC+N G +RC+C G+ D C + DEC +G + C NA C
Sbjct: 1809 IDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
Query: 494 TNTVQGHSCTCKPGYV---GNGTICRAFCEE---GCRYGGTCV---APNKCVCPSGFTGS 544
N+ + C C G+ + R C E C +G CV +C+C +GF S
Sbjct: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG-LCVDLQGSYQCICHNGFKAS 1926
Query: 545 HCEK---DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECA 601
+ D+DEC C N + C N G Y+C C GF C+DIDEC+
Sbjct: 1927 QDQTMCMDVDECERH--PCGNGT-CKNTVGSYNCLCYPGFE-----LTHNNDCLDIDECS 1978
Query: 602 LRTHTCWNDSACINLAGGFDCLCPSGPSCSGD 633
+ C N G F CLC G + D
Sbjct: 1979 SFFGQVCRNGRCFNEIGSFKCLCNEGYELTPD 2010
Score = 105 bits (261), Expect = 2e-22
Identities = 111/446 (24%), Positives = 165/446 (36%), Gaps = 93/446 (20%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C P +C+N C C SG+ ++ + C DIDEC C + +CV
Sbjct: 1075 NECKAFPGMCTYGKCRNTIGSFKCRCNSGF-ALDMEERNCTDIDECRISPDLCGSG-ICV 1132
Query: 453 NLPGLYRCDCVPGYIR--VDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG 510
N PG + C+C GY + +C + DEC C C NT C C G+
Sbjct: 1133 NTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHE- 1190
Query: 511 NGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLP 570
++P++ C DI+ECS C N +CVN+
Sbjct: 1191 -------------------LSPSREDC----------VDINECSLSDNLCRN-GKCVNMI 1220
Query: 571 GWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLC------ 624
G Y C C G+ + + C DIDEC + C D+ C N G ++C C
Sbjct: 1221 GTYQCSCNPGYQ----ATPDRQGCTDIDECMIMNGGC--DTQCTNSEGSYECSCSEGYAL 1274
Query: 625 -PSGPSCS--GDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKI--FCRRTACDCQNPSAD 679
P G SC+ +C + + GQ + + C C DG + +T D +
Sbjct: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGE--YRCLCYDGFMASMDMKTCIDVNECDLN 1332
Query: 680 LFCC--PECD-TRVTSQCLDQNGHKLYRSGDNWT---------HSCQ---QCRCLEGEVD 724
C EC+ T+ + C Q G+ + + T H+C C + G
Sbjct: 1333 SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFK 1392
Query: 725 CWPLTCPNLSCEYTAILEGECCPRCVS-DPCLADNITYDIRKTCLDSYGVSRLSGSVWTM 783
C SC I G +C+ D C I C+++ G R +
Sbjct: 1393 C--------SCREGWIGNG---IKCIDLDECSNGTHQCSINAQCVNTPGSYRCA------ 1435
Query: 784 AGSPCTTCKCKNGRVCCSVDFECLQN 809
C+ +G C VD EC +N
Sbjct: 1436 ----CSEGFTGDGFTCSDVD-ECAEN 1456
Score = 102 bits (255), Expect = 1e-21
Identities = 100/363 (27%), Positives = 137/363 (37%), Gaps = 45/363 (12%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C E P N +C N + CEC GY ++ C D DEC+ + C N C
Sbjct: 2173 NECLESPGICSNGQCINTDGSFRCECPMGY-NLDYTGVRCVDTDECSIG-NPC-GNGTCT 2229
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--G 510
N+ G + C+C G+ +C + +EC C C NT + CTC GY
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALRE 2287
Query: 511 NGTICRAF--CEEG---CRYGG----TCVAPNKCVCPSGFT----GSHCEKDIDECSEGI 557
+ +C+ C EG C G + C+CP G G C D +EC
Sbjct: 2288 DQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCV-DENECRTKP 2346
Query: 558 IECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDE----CALRTHTCWNDSAC 613
C N RCVN+ G Y CEC GF S SG C+D + + C S+
Sbjct: 2347 GICEN-GRCVNIIGSYRCECNEGFQS----SSSGTECLDNRQGLCFAEVLQTICQMASSS 2401
Query: 614 INLAGGFDCLCPSGPSCSGD---CPHEGGLKH-----NGQVWTLKEDRCSVCSCKDGKIF 665
NL +C C G CP G ++ +G +T D + CK
Sbjct: 2402 RNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYT--TDGRDIDECKVMPNL 2459
Query: 666 CRRTACDCQNPSADLFCCPECDTRVT-SQCLDQNGHKLYRSGDNW----THSCQQCRCLE 720
C C S FC T ++ + C+D + N+ T QC C
Sbjct: 2460 CTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPR 2519
Query: 721 GEV 723
G V
Sbjct: 2520 GYV 2522
Score = 95.9 bits (237), Expect = 1e-19
Identities = 100/365 (27%), Positives = 131/365 (35%), Gaps = 98/365 (26%)
Query: 460 CDCVPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G I CGS C + T C C+ GY+G T C +
Sbjct: 130 CTCSSGQIS---------STCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIG--TYCGQP 178
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDI----------DECSEGI---IECHNHS 564
CE GC+ GG C+ PN+C C GFTG CE+D ++ +G I C
Sbjct: 179 VCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTL 238
Query: 565 RCVNL-PGWYH-CE--------CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACI 614
C + W H CE CR GF ++ +C D+DEC C + CI
Sbjct: 239 CCATIGRAWGHPCEMCPAQPQPCRRGF----IPNIRTGACQDVDECQAIPGICQGGN-CI 293
Query: 615 NLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQ 674
N G F+C CP+G H T K + CS G C +C
Sbjct: 294 NTVGSFECRCPAG--------------HKQSETTQKCEDIDECSIIPG--ICE--TGECS 335
Query: 675 NPSADLFC-CPECDTRVT--SQCLDQ----------NGHKLYRSGDNWTHSCQQCRCLEG 721
N FC CP T S+C+DQ NG T QC C G
Sbjct: 336 NTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTK--MQCCCEPG 393
Query: 722 EVDCWPL-TCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 780
CW + T P E CP S+ + R+ C+D + + GS
Sbjct: 394 R--CWGIGTIP------------EACPVRGSE---------EYRRLCMDGLPMGGIPGSA 430
Query: 781 WTMAG 785
+ G
Sbjct: 431 GSRPG 435
Score = 94.4 bits (233), Expect = 4e-19
Identities = 133/537 (24%), Positives = 186/537 (34%), Gaps = 89/537 (16%)
Query: 272 TCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRR-MSCPPLNCSPDSLPVHIAGQCCKV 330
TC + + ++ D + C + C +GA CR + CSP S C
Sbjct: 836 TCPPGYVFRTETETCEDINECESNPCVNGA--CRNNLGSFNCECSPGSKLSSTGLICIDS 893
Query: 331 CRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCS--------EKDHILPE 382
+ C I C G +K +E C L + E D P
Sbjct: 894 LKGTCWLN---------IQDSRCEVNINGATLK-SECCATLGAAWGSPCERCELDTACPR 943
Query: 383 NQCCRV----CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDEC 438
R+ C N C P N C N CEC G +++ G C DI
Sbjct: 944 G-LARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEG-LTLDGTGRVCLDI--- 998
Query: 439 AAKMHYCHA---NTVCVN-LPGLYRCD-CVPGYIRVDDFSCTEHDECGSGQHN--CDENA 491
+M C+ C++ +PG +R D C C E + G+ ++ C A
Sbjct: 999 --RMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGA 1056
Query: 492 ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG--GTCVAPNKCVCPSGFTGSHCEK- 548
N +G T +P Y C+AF C YG + KC C SGF E+
Sbjct: 1057 GFAN--RGDVLTGRPFYKDINE-CKAF-PGMCTYGKCRNTIGSFKCRCNSGFALDMEERN 1112
Query: 549 --DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHT 606
DIDEC C CVN PG + CEC G+ + ++C+DIDEC
Sbjct: 1113 CTDIDECRISPDLC-GSGICVNTPGSFECECFEGYESG---FMMMKNCMDIDECERNPLL 1168
Query: 607 CWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFC 666
C C+N G F C CP G S +ED + C C
Sbjct: 1169 C-RGGTCVNTEGSFQCDCPLGHELSPS----------------REDCVDINECSLSDNLC 1211
Query: 667 RRTACDCQNPSADLFCCPECDTRVTSQ-CLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDC 725
R C + C P Q C D + + G + QC EG +C
Sbjct: 1212 RNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD-----TQCTNSEGSYEC 1266
Query: 726 WPLTCPNLSCEYTAILEGECC---PRCVSDPCLAD-----NITYDIRKTCLDSYGVS 774
+ S Y + +G C C ++P + D NI + R C D + S
Sbjct: 1267 ------SCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMAS 1317
Score = 94.4 bits (233), Expect = 4e-19
Identities = 107/393 (27%), Positives = 143/393 (36%), Gaps = 96/393 (24%)
Query: 395 CAEGP-KCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C+ G +C N++C N C C G+ GD C D+DECA ++ C N C+N
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT---GDGFTCSDVDECAENINLCE-NGQCLN 1467
Query: 454 LPGLYRCDCVPGYIRVDDF-SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--- 509
+PG YRC+C G+ D SC + DEC S Q+ C C N C C GY
Sbjct: 1468 VPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNICVFGT-CNNLPGMFHCICDDGYELDR 1525
Query: 510 --GNGTICRAFCEEGCRYGGTCV-APNK--CVCPSGF----TGSHC-EKDIDEC------ 553
GN T + G CV P + C CP F TG C + + C
Sbjct: 1526 TGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGP 1585
Query: 554 -SEGIIECHNH--------SRCVNL-PGWYH-CECRSGFHDDGTYSL--SGES------- 593
+G + C+ S C +L W + CE + Y+L GE
Sbjct: 1586 RGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPIT 1645
Query: 594 --CIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGD---------CPHEGGLKH 642
DIDEC C + CIN G F C CP G S D C G+
Sbjct: 1646 IILEDIDECQELPGLCQGGN-CINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCG 1704
Query: 643 NGQVWTLKEDRCSVC-----------SCKD-GKIFCRR----TACDCQ---NPSADLFCC 683
G + + +C +C D K FC R T C+ + N + + CC
Sbjct: 1705 PGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCC 1764
Query: 684 PECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC 716
Y G W C+ C
Sbjct: 1765 ------------------TYNVGKAWNKPCEPC 1779
Score = 91.7 bits (226), Expect = 3e-18
Identities = 136/542 (25%), Positives = 192/542 (35%), Gaps = 117/542 (21%)
Query: 267 CHCEK--TCQVSGLLYRDQDSWVDGDHCRNCTCKS--GAVECRRMSC-------PPLNCS 315
C C +G+ D D G+ C N TC + G+ EC +C P +NC
Sbjct: 2196 CECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFEC---NCNEGFEPGPMMNCE 2252
Query: 316 PDSLPVHIAGQCCKVCRPKCI--YG--------GKVLAEGQRILTKSCRECRGGV----- 360
++ Q +C +C+ +G G L E Q+ + K EC G+
Sbjct: 2253 D----INECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK-MCKDLDECAEGLHDCES 2307
Query: 361 --------LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNT 412
+ +CPP D C N C P EN C N
Sbjct: 2308 RGMMCKNLIGTFMCICPPGMARRPDG--------EGCVDENECRTKPGICENGRCVNIIG 2359
Query: 413 KATCECKSGYISVQGDSAYCEDIDE----CAAKM--HYCHANTVCVNLPGLYRCDCVPGY 466
CEC G+ Q S+ E +D C A++ C + NL C C G
Sbjct: 2360 SYRCECNEGF---QSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGR 2416
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG-TICRAFCEEGCRY 525
G G H C+ + C PGY +G I
Sbjct: 2417 --------------GWG-HQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCT 2461
Query: 526 GGTCV---APNKCVCPSGFT----GSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECR 578
G C+ +C C G+T G+ C D+DECS+ C + C N G Y C C
Sbjct: 2462 NGQCINTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSPKPC--NYICKNTEGSYQCSCP 2518
Query: 579 SGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEG 638
G+ G++C D+DEC + H C C+N GGF C CP G + H
Sbjct: 2519 RGY----VLQEDGKTCKDLDECQTKQHNC--QFLCVNTLGGFTCKCPPGFT-----QHHT 2567
Query: 639 GLKHNGQVWTLKEDRCSVCSCKDGKIFCRRT----ACDCQN----PSADLFC--CPECDT 688
N + + + S+C K C+ T +C+CQ + L C ECD
Sbjct: 2568 ACIDNNECGS----QPSLCGAKG---ICQNTPGSFSCECQRGFSLDATGLNCEDVDECDG 2620
Query: 689 RVTSQCLDQNGHKLYRSG--DNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGEC- 745
Q QN YR G + Q +C++ P C + SC Y + +C
Sbjct: 2621 NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASC-YNTLGSYKCA 2679
Query: 746 CP 747
CP
Sbjct: 2680 CP 2681
Score = 87.4 bits (215), Expect = 5e-17
Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 44/217 (20%)
Query: 433 EDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAI 492
+ ID C + C N C+ YRC+C GY + + C + DEC S N N
Sbjct: 493 QTIDICKHHANLC-LNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTS---NPCTNGD 548
Query: 493 CTNTVQGHSCTCKPGY---------------VGNGTICRAFCEEGCRYGGTCVAPN---K 534
C NT + C C G+ + NG +C+ G CV + +
Sbjct: 549 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCK---------NGRCVNTDGSFQ 599
Query: 535 CVCPSGF----TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLS 590
C+C +GF G +C D DEC+ + C N C+N G + C C+ GF + +
Sbjct: 600 CICNAGFELTTDGKNC-VDHDECTTTNM-CLN-GMCINEDGSFKCICKPGF----VLAPN 652
Query: 591 GESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
G C D+DEC +T + CIN G F C CP G
Sbjct: 653 GRYCTDVDEC--QTPGICMNGHCINSEGSFRCDCPPG 687
Score = 84.0 bits (206), Expect = 5e-16
Identities = 77/257 (29%), Positives = 96/257 (37%), Gaps = 51/257 (19%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C G C N C C GY + C DIDECA ++ N
Sbjct: 1495 CSFQNICVFGT-------CNNLPGMFHCICDDGY-ELDRTGGNCTDIDECADPINC--VN 1544
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEH--DEC-------GSGQHNCDENAICTNTVQ 498
+CVN PG Y C+C P + + C ++ C G G +C N V
Sbjct: 1545 GLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSC--NTEIGVGVS 1602
Query: 499 GHSCTCKPGYV-GNGTICRAFCEEGCRYGGTCVAPNK----CVCP--SGFTGSHCE---K 548
SC C G GN CE TC N +CP GF + +
Sbjct: 1603 RSSCCCSLGKAWGNP------CE-------TCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
Query: 549 DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCW 608
DIDEC E C C+N G + CEC G++ S C DIDEC C
Sbjct: 1650 DIDECQELPGLCQG-GNCINTFGSFQCECPQGYY----LSEDTRICEDIDECFAHPGVC- 1703
Query: 609 NDSACINLAGGFDCLCP 625
C N G + C+CP
Sbjct: 1704 GPGTCYNTLGNYTCICP 1720
Score = 84.0 bits (206), Expect = 5e-16
Identities = 109/431 (25%), Positives = 149/431 (34%), Gaps = 102/431 (23%)
Query: 387 RVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCH 446
R+C + C P C N TC C Y+ V G C D+ + Y
Sbjct: 1688 RICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNG-GHNCMDMRKSFCYRSY-- 1744
Query: 447 ANTVCVN-----------------------------LPGLYR----CDCVPGY-IRVDDF 472
T C N PG C +PG+ +
Sbjct: 1745 NGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTG 1804
Query: 473 SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG--TICRAF--CEEG---CRY 525
+ DEC C N +C N + C C G+ N +C C G C+
Sbjct: 1805 KAVDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQR 1863
Query: 526 GGTCV---APNKCVCPSGFTGSHCEKDID--ECSEGIIECHNHSRCVNLPGWYHCECRSG 580
C+ +C C +GF S +D EC E I +H CV+L G Y C C +G
Sbjct: 1864 NADCINSPGSYRCECAAGFKLSPNGACVDRNECLE-IPNVCSHGLCVDLQGSYQCICHNG 1922
Query: 581 FHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGL 640
F ++ C+D+DEC H C N C N G ++CLC G L
Sbjct: 1923 FKASQDQTM----CMDVDEC--ERHPCGN-GTCKNTVGSYNCLCYPGFE----------L 1965
Query: 641 KHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGH 700
HN + E CS G++ CR C + S +CL G+
Sbjct: 1966 THNNDCLDIDE-----CSSFFGQV-CRNGRCFNEIGS--------------FKCLCNEGY 2005
Query: 701 KLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAI------LEGECC---PRCVS 751
+L G N + +C L G C P TC NL + I ++ E C C
Sbjct: 2006 ELTPDGKNCIDT-NECVALPG--SCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDE 2062
Query: 752 DP--CLADNIT 760
DP CL + T
Sbjct: 2063 DPNICLFGSCT 2073
Score = 76.6 bits (187), Expect = 8e-14
Identities = 118/500 (23%), Positives = 164/500 (32%), Gaps = 126/500 (25%)
Query: 366 EMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISV 425
EMCP + +P N C+ + C P + C N C C +G+
Sbjct: 252 EMCPAQPQPCRRGFIP-NIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQS 310
Query: 426 QGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFS-CTEH--DECGS 482
+ + CEDIDEC+ C C N G Y C C GY+ D S C + C S
Sbjct: 311 E-TTQKCEDIDECSIIPGICETGE-CSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFS 368
Query: 483 GQHNCDENAICTNTVQGH----SCTCKPGYV-GNGTI-----------CRAFCEEGCRYG 526
G N C + G C C+PG G GTI R C +G G
Sbjct: 369 GL----VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMG 424
Query: 527 GTCVAPNKCVCPSGFTGSH----------------------------------------- 545
G P G TG +
Sbjct: 425 G---IPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQ 481
Query: 546 ---------CEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCID 596
+ ID C C N RC+ Y CEC G+ D + CID
Sbjct: 482 GPIITGLTILNQTIDICKHHANLCLN-GRCIPTVSSYRCECNMGYKQD-----ANGDCID 535
Query: 597 IDECALRTHTCWNDSACINLAGGFDCLC-------PSGPSC--SGDCPHEGGLKHNGQVW 647
+DEC ++ C N C+N G + C C P+ +C +C G L NG+
Sbjct: 536 VDECT--SNPCTNGD-CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR-- 590
Query: 648 TLKEDRCSVCSCK-------DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGH 700
+ D C C DGK C N + C E + +C+ + G
Sbjct: 591 CVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG---SFKCICKPGF 647
Query: 701 KLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNIT 760
L +G + +C+ P C N C + E RC P LA +
Sbjct: 648 VLAPNG-RYCTDVDECQT--------PGICMNGHC-----INSEGSFRCDCPPGLAVGMD 693
Query: 761 YDIRKTCLDSYGVSRLSGSV 780
+ C+D++ S G +
Sbjct: 694 ---GRVCVDTHMRSTCYGGI 710
Score = 71.2 bits (173), Expect = 4e-12
Identities = 80/308 (25%), Positives = 108/308 (35%), Gaps = 59/308 (19%)
Query: 335 CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNF 394
C G K L G + + CR G MC CS Q C +
Sbjct: 97 CCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMC---TCSS-------GQISSTCGSKSI 146
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
+C C + + C+C+ GYI CE + C C+
Sbjct: 147 QQCSVRCMNGGTCADDH----CQCQKGYIGTYCGQPVCE---------NGCQNGGRCI-- 191
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTI 514
G RC CV G+ E D N +C + G CT T+
Sbjct: 192 -GPNRCACVYGFTGPQ----CERDYRTGPCFTQVNNQMCQGQLTGIVCT--------KTL 238
Query: 515 CRAFCEEGCRYGGTC----VAPNKC---VCPSGFTGSHCEKDIDECS--EGIIECHNHSR 565
C A G +G C P C P+ TG+ C+ D+DEC GI + N
Sbjct: 239 CCATI--GRAWGHPCEMCPAQPQPCRRGFIPNIRTGA-CQ-DVDECQAIPGICQGGN--- 291
Query: 566 CVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP 625
C+N G + C C +G T + C DIDEC++ C C N G + C+CP
Sbjct: 292 CINTVGSFECRCPAGHKQSET----TQKCEDIDECSIIPGIC-ETGECSNTVGSYFCVCP 346
Query: 626 SGPSCSGD 633
G S D
Sbjct: 347 RGYVTSTD 354
Score = 50.1 bits (118), Expect = 8e-06
Identities = 48/184 (26%), Positives = 67/184 (36%), Gaps = 36/184 (19%)
Query: 492 ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHC-EKDI 550
+C + + C G C C G C PN C C SG S C K I
Sbjct: 88 VCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG-DGFCSRPNMCTCSSGQISSTCGSKSI 146
Query: 551 DECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWND 610
+CS + C N C + HC+C+ G+ GTY G+ + + C N
Sbjct: 147 QQCS---VRCMNGGTCAD----DHCQCQKGY--IGTY--CGQPVCE--------NGCQNG 187
Query: 611 SACINLAGGFDCLCP---SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCR 667
CI G C C +GP C D G +T ++ +C + I C
Sbjct: 188 GRCI---GPNRCACVYGFTGPQCERD-------YRTGPCFTQVNNQ--MCQGQLTGIVCT 235
Query: 668 RTAC 671
+T C
Sbjct: 236 KTLC 239
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 155 bits (393), Expect = 1e-37
Identities = 117/399 (29%), Positives = 171/399 (42%), Gaps = 54/399 (13%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPP------ 311
E+ ++NC CQ LL R G C N G+ C CPP
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCR-------GGVCHNT---EGSYRCE---CPPGHQLSP 1148
Query: 312 -----LNCSPDSLPVHIA--GQCCKVC-RPKCIYGGKVLAEGQRILTKSCREC---RGGV 360
++ + L H+ G+C + + +C + R+ EC GG
Sbjct: 1149 NISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC 1208
Query: 361 LVKITEMCPPLNCSEKDH--ILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCEC 418
T CS + ++P+ R C + C + P + +C N + C C
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPDQ---RSCTDIDECEDNPNICDGGQCTNIPGEYRCLC 1265
Query: 419 KSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYI-RVDDFSCTEH 477
G+++ + D C D++EC + C + T C N G + C C GY + CT+
Sbjct: 1266 YDGFMASE-DMKTCVDVNECDLNPNICLSGT-CENTKGSFICHCDMGYSGKKGKTGCTDI 1323
Query: 478 DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF--CEEG---CRYGGTC--- 529
+EC G HNC ++A+CTNT C+C PG++G+G C C G C C
Sbjct: 1324 NECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNT 1383
Query: 530 VAPNKCVCPSGFTGSHCE-KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYS 588
+ +C+C G+TG D+DECSE + C N +C+N PG Y CEC GF S
Sbjct: 1384 MGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGN-GQCLNAPGGYRCECDMGF----VPS 1438
Query: 589 LSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
G++C DIDEC+L + C NL G F C C G
Sbjct: 1439 ADGKACEDIDECSLPNICVF--GTCHNLPGLFRCECEIG 1475
Score = 150 bits (378), Expect = 6e-36
Identities = 163/576 (28%), Positives = 216/576 (37%), Gaps = 110/576 (19%)
Query: 292 CRN------CTCKSG-AVECRRMSCPPLNCSPDSLPVHIAGQCCKV---CRPKCIYGGKV 341
CRN C C SG A++ +C ++ S + GQC KC G
Sbjct: 1044 CRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEG--- 1100
Query: 342 LAEGQRILTKSCRE----------CRGGVLVKITEM----CPPLNCSEKDHILPENQCCR 387
E ++ K+C + CRGGV CPP H L N
Sbjct: 1101 -YESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPP------GHQLSPN--IS 1151
Query: 388 VCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C N C N C N K C C GY S D +C DIDEC+ C
Sbjct: 1152 ACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTP-DRLFCVDIDECSIMNGGCE- 1209
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
T C N G Y C C PG+ + D SCT+ DEC + CD CTN + C C
Sbjct: 1210 -TFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQ-CTNIPGEYRCLCYD 1267
Query: 507 GYVGNGTICRAFCEEGCRYG------GTCVAPNK---CVCPSGFTGSHCEK---DIDECS 554
G++ + + C GTC C C G++G + DI+EC
Sbjct: 1268 GFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECE 1327
Query: 555 EGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACI 614
G C H+ C N G + C C G+ DG C D+DEC+ TH C + C
Sbjct: 1328 IGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGI------KCTDLDECSNGTHMCSQHADCK 1381
Query: 615 NLAGGFDCLCPSGPSCSG-------DCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKI-FC 666
N G + CLC G + G +C L NGQ L C C G +
Sbjct: 1382 NTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQ--CLNAPGGYRCECDMGFVPSA 1439
Query: 667 RRTAC----DCQNPSADLF-CCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG 721
AC +C P+ +F C +C + G++L RSG N T + CL+
Sbjct: 1440 DGKACEDIDECSLPNICVFGTCHNLPGLFRCEC--EIGYELDRSGGNCTDVNE---CLD- 1493
Query: 722 EVDCWPLTCPNLSCEYT-AILEGECCPRCVSDP----CL---ADNITYDIR-------KT 766
P TC + +C T +C P +P C+ + N DIR
Sbjct: 1494 -----PTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTA 1548
Query: 767 CLD--SYGVSRLS-----GSVWTMAGSPCTTCKCKN 795
C + GVS+ S G W G+PC C N
Sbjct: 1549 CSNEIGVGVSKASCCCSLGKAW---GTPCEMCPAVN 1581
Score = 144 bits (364), Expect = 3e-34
Identities = 121/446 (27%), Positives = 168/446 (37%), Gaps = 66/446 (14%)
Query: 314 CSPDSLPVHIAGQCCKVCRPKCI---YGGKVLAEGQRILTKSCRECR-----GGVLVKIT 365
C PD + V+ C + R C Y +G+ + + + C G K
Sbjct: 1674 CPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPC 1733
Query: 366 EMCPPLNCSEKDHILPENQCCRVCRGH-------NFCAEGPKCGENSECKNWNTKATCEC 418
E CP + E + + V + + C E P EN C N CEC
Sbjct: 1734 EQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCEC 1793
Query: 419 KSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHD 478
G+ CEDIDEC C N C+N G YRCDC PGY C + +
Sbjct: 1794 PVGFF-YNDKLLVCEDIDECQ-NGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRN 1851
Query: 479 ECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG--TICRAF--CEEGCRYGGTC---VA 531
EC + C C +TV C C G+ N T+C CE GTC +
Sbjct: 1852 ECQEIPNICSHGQ-CIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIG 1910
Query: 532 PNKCVCPSGFTGSHCEK--DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSL 589
C C GF SH D+DEC+ G + +C+N G + C+C G+ +
Sbjct: 1911 SFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYE----VAP 1966
Query: 590 SGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTL 649
G +C+DI+EC L C C NL G + C+CP G ++L
Sbjct: 1967 DGRTCVDINECLLEPRKC-APGTCQNLDGSYRCICPPG-------------------YSL 2006
Query: 650 KEDRC-SVCSCKDGKIFCRRTACDCQNPSADLFC-CPE----------CDTRVTSQCLDQ 697
+ ++C + C + C C N C CPE C S C +
Sbjct: 2007 QNEKCEDIDECVEEPEIC--ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAK 2064
Query: 698 NGHKLYRSGDNWTHSCQQCRC-LEGE 722
S + HS Q+C C L+GE
Sbjct: 2065 FEGGKCSSPKSRNHSKQECCCALKGE 2090
Score = 128 bits (321), Expect = 2e-29
Identities = 153/603 (25%), Positives = 218/603 (36%), Gaps = 123/603 (20%)
Query: 276 SGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKV---CR 332
SG++ DS VD D C+ PD V GQC R
Sbjct: 2115 SGIIVGPDDSAVDMDECK---------------------EPD---VCKHGQCINTDGSYR 2150
Query: 333 PKCIYGGKVLAEGQRILTKSC---RECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVC 389
+C + G +LA + + T C C G + C+ ++ P C
Sbjct: 2151 CECPF-GYILAGNECVDTDECSVGNPCGNGTCKNV---IGGFECTCEEGFEPGPM--MTC 2204
Query: 390 RGHNFCAEGP-KCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
N CA+ P C C N C+C GY+ ++ D C+D DEC H C
Sbjct: 2205 EDINECAQNPLLCA--FRCVNTYGSYECKCPVGYV-LREDRRMCKDEDECEEGKHDCTEK 2261
Query: 449 TV-CVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
+ C NL G Y C C PGY R D C + +EC + C EN C NT ++C C
Sbjct: 2262 QMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECND 2320
Query: 507 GYVG--NGTIC----RAFC-----EEGCRYGGT---CVAPNKCVCPSG-FTGSHCE---- 547
G+ N C +C + C+ G + V ++C C G G HCE
Sbjct: 2321 GFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPF 2380
Query: 548 --------------------KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTY 587
DIDEC C N CVN G YHC C++G+ D
Sbjct: 2381 QGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRN-GECVNDRGSYHCICKTGYTPD--- 2436
Query: 588 SLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP-------SGPSCSGDCPHEGGL 640
++G SC+D++EC C + C N G + C CP G SC D
Sbjct: 2437 -ITGTSCVDLNECNQAPKPC--NFICKNTEGSYQCSCPKGYILQEDGRSCK-DLDECATK 2492
Query: 641 KHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPE---C-DTRVTSQCLD 696
+HN Q + C C G + D ++D+ C C +T + C
Sbjct: 2493 QHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCEC 2552
Query: 697 QNGHKLYRSGDN--------WTHSCQQ-CRCLEGEVDCWPLTCPNLSCEY----TAILEG 743
Q G L ++G + H CQ C+ + G C +CP ++ + E
Sbjct: 2553 QRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRC---SCPQGYLQHYQWNQCVDEN 2609
Query: 744 ECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTM-----AGSPCT-TCKCKNGR 797
EC + N + C + + SG + A +PC+ C G
Sbjct: 2610 ECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGG 2669
Query: 798 VCC 800
C
Sbjct: 2670 YLC 2672
Score = 123 bits (309), Expect = 6e-28
Identities = 85/253 (33%), Positives = 111/253 (43%), Gaps = 31/253 (12%)
Query: 389 CRGHNFCAEGPK-CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C N C + PK C N CKN C C GYI +Q D C+D+DECA K H C
Sbjct: 2442 CVDLNECNQAPKPC--NFICKNTEGSYQCSCPKGYI-LQEDGRSCKDLDECATKQHNCQF 2498
Query: 448 NTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
+CVN G + C C PG+ + SC +++EC S + C IC NT +C C+ G
Sbjct: 2499 --LCVNTIGGFTCKCPPGFTQ-HHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRG 2555
Query: 508 YV--GNGTICRAF--------CEEGCRYGGTCVAPNKCVCPSGFTGSHCEK---DIDECS 554
+ G+ C C+ GC+ + +C CP G+ + D +EC
Sbjct: 2556 FSLDQTGSSCEDVDECEGNHRCQHGCQ---NIIGGYRCSCPQGYLQHYQWNQCVDENECL 2612
Query: 555 EGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACI 614
I C S C N G Y C C +GF Y C DI+EC C C
Sbjct: 2613 SAHI-CGGAS-CHNTLGSYKCMCPAGFQ----YEQFSGGCQDINECGSAQAPC--SYGCS 2664
Query: 615 NLAGGFDCLCPSG 627
N GG+ C CP G
Sbjct: 2665 NTEGGYLCGCPPG 2677
Score = 120 bits (301), Expect = 5e-27
Identities = 157/609 (25%), Positives = 212/609 (34%), Gaps = 155/609 (25%)
Query: 278 LLYRDQDSWVDGDHC-RNCTC--KSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPK 334
L+ D D +G C RN C +G+ C +C P GQC R +
Sbjct: 1804 LVCEDIDECQNGPVCQRNAECINTAGSYRC--------DCKP-GYRFTSTGQCND--RNE 1852
Query: 335 CIYGGKVLAEGQRILTKSCRECRGGVLVKITE---MCPPLNCSEKDHILPENQCCRVCRG 391
C + + GQ I T C K + MC +N E+D N CR G
Sbjct: 1853 CQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDAC--GNGTCRNTIG 1910
Query: 392 --------------HNFCAEGPKCGE-------NSECKNWNTKATCECKSGYISVQGDSA 430
+N C + +C N +C N C+C GY V D
Sbjct: 1911 SFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGY-EVAPDGR 1969
Query: 431 YCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDEN 490
C DI+EC + C T C NL G YRC C PGY + + C + DEC C
Sbjct: 1970 TCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGY-SLQNEKCEDIDECVEEPEICALG 2027
Query: 491 AICTNTVQGHSCTCKPGYV--GNGTICRAFCEEGCRY---GGTCVAPNK---------CV 536
C+NT C C G+ +G C+ C GG C +P C
Sbjct: 2028 T-CSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCA 2086
Query: 537 CPSGFTGSHCEK----------------------------DIDECSEGIIECHNHSRCVN 568
G CE D+DEC E + C H +C+N
Sbjct: 2087 LKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDV-C-KHGQCIN 2144
Query: 569 LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 628
G Y CEC G Y L+G C+D DEC++ + C N + C N+ GGF+C C G
Sbjct: 2145 TDGSYRCECPFG------YILAGNECVDTDECSVG-NPCGNGT-CKNVIGGFECTCEEG- 2195
Query: 629 SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFC-CP--- 684
G + T ++ + C + C A C N C CP
Sbjct: 2196 ------------FEPGPMMTCED----INECAQNPLLC---AFRCVNTYGSYECKCPVGY 2236
Query: 685 --ECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWP--LTCPNLSCEYTAI 740
D R+ C D++ C EG+ DC + C NL Y I
Sbjct: 2237 VLREDRRM---CKDED------------------ECEEGKHDCTEKQMECKNLIGTYMCI 2275
Query: 741 LEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 800
R + C+ +N C G+ +G GS TC+C +G
Sbjct: 2276 CGPGYQRRPDGEGCVDEN-------ECQTKPGICE-NGRCLNTRGS--YTCECNDGFTAS 2325
Query: 801 SVDFECLQN 809
ECL N
Sbjct: 2326 PNQDECLDN 2334
Score = 117 bits (294), Expect = 3e-26
Identities = 159/656 (24%), Positives = 236/656 (35%), Gaps = 140/656 (21%)
Query: 261 LSQLENCHCEKTCQV--SGLLYRDQDSWVDGDHC--RNCTCKSGAVECRRMSCPP---LN 313
L L C CE ++ SG D + +D C NC G+ C CPP LN
Sbjct: 1464 LPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYIC---DCPPDFELN 1520
Query: 314 CSPDSLPVHIAGQCCKVCRPKCIYGGKVLAE--GQRILTKSCRECRGGVLVKITEMCPPL 371
+ +G C RP+ G + G + SC G EMCP +
Sbjct: 1521 PTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAV 1580
Query: 372 NCSEKDHILPENQCCR------VCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISV 425
N SE + P + R + + C E P + +C N C C +GY +
Sbjct: 1581 NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYY-L 1639
Query: 426 QGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVD-DFSCTE------HD 478
D+ C+D++EC C T C N G Y C C P Y++V+ +C + +
Sbjct: 1640 NEDTRVCDDVNECETP-GICGPGT-CYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYR 1697
Query: 479 ECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN--------------GTICRA------- 517
+ CD + T + C+ G N T+C +
Sbjct: 1698 NYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVI 1757
Query: 518 -----------FCEE--GCRYGGTC---VAPNKCVCPSGFTGSH----CEKDIDECSEGI 557
C E G G C V +C CP GF + CE DIDEC G
Sbjct: 1758 DIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCE-DIDECQNGP 1816
Query: 558 IECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLA 617
+ C ++ C+N G Y C+C+ G+ ++ +G+ C D +EC + C + CI+
Sbjct: 1817 V-CQRNAECINTAGSYRCDCKPGYR----FTSTGQ-CNDRNECQEIPNIC-SHGQCIDTV 1869
Query: 618 GGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS----------------VCSCKD 661
G F CLC H G ++ Q L + C C C
Sbjct: 1870 GSFYCLC-----------HTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNH 1918
Query: 662 GKIFCRRTAC----DCQNPSADLFCCPECDTRVTS-QCLDQNGHKLYRSGDNWTHSCQQC 716
G I C +C + + +L +C V S QC G+++ G +C
Sbjct: 1919 GFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDG----RTCVDI 1974
Query: 717 -RCLEGEVDCWPLTCPNLSCEYTAI------LEGECC---PRCVSDPCL-----ADNITY 761
CL C P TC NL Y I L+ E C CV +P + N
Sbjct: 1975 NECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEG 2034
Query: 762 DIRKTCLDSYGVS---------RLSGSVWTMAGSPCTTCKCKN---GRVCCSVDFE 805
+ C + + +S R+S G C++ K +N CC++ E
Sbjct: 2035 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE 2090
Score = 115 bits (289), Expect = 1e-25
Identities = 142/540 (26%), Positives = 202/540 (37%), Gaps = 153/540 (28%)
Query: 316 PDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR-ECRGGVLVKITEMCPPLNCS 374
P LPV++ C ++ R C G + G SCR EC G + + C ++
Sbjct: 442 PRVLPVNVTDYC-QLVRYLCQNGRCIPTPG------SCRCECNKGFQLDLRGECIDVDEC 494
Query: 375 EKDHILPENQC----------CRV----------CRGHNFCAEGPKCGENSECKNWNTKA 414
EK+ +C CR CR + C + + N C N +
Sbjct: 495 EKNPCAG-GECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSF 553
Query: 415 TCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFS 473
C C +G+ V D CED+DEC+ + + C N +C+N G ++C C PG+ + D
Sbjct: 554 HCVCNAGF-HVTRDGKNCEDMDECSIR-NMC-LNGMCINEDGSFKCICKPGFQLASDGRY 610
Query: 474 CTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY-VG-NGTIC-----RAFCEEGCRYG 526
C + +EC + N C NT + C C PG VG +G +C R+ C G + G
Sbjct: 611 CKDINECETP--GICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRG 668
Query: 527 GTCVAP-------NKCVCPSG--FTGSHCE------------------------KDIDEC 553
C+ P ++C C S G C+ DI+EC
Sbjct: 669 -QCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINEC 727
Query: 554 SEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSAC 613
+ C N C NL G Y C C SG+ D T G++C+DI+EC L + C N C
Sbjct: 728 ALDPDICPN-GICENLRGTYKCICNSGYEVDST----GKNCVDINECVLNSLLCDNGQ-C 781
Query: 614 INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDC 673
N G F C CP G D LK + D C C +G C
Sbjct: 782 RNTPGSFVCTCPKGFIYKPD------LKTCEDI-----DECESSPCINGV---------C 821
Query: 674 QNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG-EVDCWPLTCPN 732
+N C EC + T LD + C+E + CW
Sbjct: 822 KNSPGSFIC--ECSSEST---LDPT----------------KTICIETIKGTCWQ----- 855
Query: 733 LSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCK 792
+++G C +I L S S L G+ W GSPCT C+
Sbjct: 856 ------TVIDGRC--------------EININGATLKSQCCSSL-GAAW---GSPCTLCQ 891
Score = 114 bits (286), Expect = 3e-25
Identities = 137/557 (24%), Positives = 180/557 (32%), Gaps = 164/557 (29%)
Query: 353 CRE----CRGGVLVKITEM--CP-PLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENS 405
CRE C GV + + C P+ D +L VC + C GP C N+
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLL-------VCEDIDECQNGPVCQRNA 1822
Query: 406 ECKNWNTKATCECKSGY----------------------------------------ISV 425
EC N C+CK GY
Sbjct: 1823 ECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882
Query: 426 QGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQH 485
D C DI+EC + C N C N G + C C G+I + C + DEC SG
Sbjct: 1883 NDDQTMCLDINEC--ERDAC-GNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNG 1939
Query: 486 NCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSH 545
N N C NTV C C GY E G TCV N+C+
Sbjct: 1940 NLCRNGQCINTVGSFQCQCNEGY------------EVAPDGRTCVDINECLL-------- 1979
Query: 546 CEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTH 605
+ +C+ G C NL G Y C C G YSL E C DIDEC
Sbjct: 1980 ---EPRKCAPG--------TCQNLDGSYRCICPPG------YSLQNEKCEDIDECVEEPE 2022
Query: 606 TCWNDSACINLAGGFDCLCPSGPSCS--------------------GDCPHEGGLKHN-- 643
C C N G F CLCP G S S G C H+
Sbjct: 2023 IC-ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQ 2081
Query: 644 -------GQVWTLKEDRCSVCSCKDGKIFCRRTACDC--------QNPSADLFCCPECDT 688
G+ W D C +C + + F R C + + D+ C E D
Sbjct: 2082 ECCCALKGEGW---GDPCELCPTEPDEAF--RQICPYGSGIIVGPDDSAVDMDECKEPDV 2136
Query: 689 RVTSQCLDQNGHKLYRSGDNWTHSCQQC----RCLEGEVDCWPLTCPNL------SCEY- 737
QC++ +G + + +C C G C TC N+ +CE
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGN-PCGNGTCKNVIGGFECTCEEG 2195
Query: 738 ---TAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCK-- 792
++ E C +P L C+++YG V + CK
Sbjct: 2196 FEPGPMMTCEDINECAQNPLLC-------AFRCVNTYGSYECKCPVGYVLREDRRMCKDE 2248
Query: 793 --CKNGR-VCCSVDFEC 806
C+ G+ C EC
Sbjct: 2249 DECEEGKHDCTEKQMEC 2265
Score = 112 bits (279), Expect = 2e-24
Identities = 135/526 (25%), Positives = 190/526 (36%), Gaps = 110/526 (20%)
Query: 366 EMCPPLNCSEKDHILPENQ---CCRVCRGHNF------CAEGPKCGENSECKNWNTKATC 416
E CP N E + + P + G F C P + +C+N C
Sbjct: 994 EECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKC 1053
Query: 417 ECKSGYISVQGDSAYCEDIDECAAKMHYCH----ANT----------------------- 449
C SG+ ++ + C DIDEC C NT
Sbjct: 1054 RCDSGF-ALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCM 1112
Query: 450 ---------------VCVNLPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAIC 493
VC N G YRC+C PG+ + S C + +EC H C N C
Sbjct: 1113 DIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLC-PNGRC 1171
Query: 494 TNTVQGHSCTCKPGYVGNGTICRAFCEE---------GCR-YGGTCVAPNKCVCPSGFTG 543
N + + C C PGY + T R FC + GC + +C C GF
Sbjct: 1172 VNLIGKYQCACNPGY--HSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL 1229
Query: 544 SHCEK---DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
++ DIDEC + C + +C N+PG Y C C GF S ++C+D++EC
Sbjct: 1230 MPDQRSCTDIDECEDNPNIC-DGGQCTNIPGEYRCLCYDGF----MASEDMKTCVDVNEC 1284
Query: 601 ALRTHTCWNDSACINLAGGFDCLCPSGPS-------CSGDCPHEGGLKHNGQVWTLKEDR 653
L + C + C N G F C C G S C+ E G + G+
Sbjct: 1285 DLNPNICLS-GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTA 1343
Query: 654 CSV-CSCKDGKIFCRRTACDCQNPSADLFCC---PEC-DTRVTSQCLDQNGHKLYRSGDN 708
S CSC G I D S C +C +T + +CL + G+ +GD
Sbjct: 1344 GSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY----TGDG 1399
Query: 709 WT----HSCQQCRCLEGEVDCWPLTCP-NLSCE----YTAILEGECCPRCVSDPCLADNI 759
+T C + L G C L P CE + +G+ C D C NI
Sbjct: 1400 FTCTDLDECSENLNLCGNGQC--LNAPGGYRCECDMGFVPSADGKACEDI--DECSLPNI 1455
Query: 760 TYDIRKTCLDSYGVSRLS---GSVWTMAGSPCTTC-KCKNGRVCCS 801
+ TC + G+ R G +G CT +C + C S
Sbjct: 1456 C--VFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCIS 1499
Score = 110 bits (274), Expect = 7e-24
Identities = 138/548 (25%), Positives = 190/548 (34%), Gaps = 102/548 (18%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVEC-RRMSCPPLNCSPDSLPVHIAG 325
C C K Q+ + +D D C C G EC C
Sbjct: 474 CECNKGFQLDL-----RGECIDVDECEKNPCAGG--ECINNQGSYTCQCRAGYQSTLTRT 526
Query: 326 QCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQC 385
+C + +C+ G++ G+ I T C +T NC + D N C
Sbjct: 527 ECRDI--DECLQNGRICNNGRCINTDGSFHCVCNAGFHVTR--DGKNCEDMDECSIRNMC 582
Query: 386 CRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYC 445
N C N + C CK G+ + D YC+DI+EC C
Sbjct: 583 L-----------------NGMCINEDGSFKCICKPGF-QLASDGRYCKDINECETP-GIC 623
Query: 446 HANTVCVNLPGLYRCDCVPGY-IRVDDFSCTE---HDECGSGQHNCDENAICTNTVQGHS 501
N CVN G YRC+C PG + +D C + C G V
Sbjct: 624 -MNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSE 682
Query: 502 CTCKPGYVGNGTICRAFCEEGCRYGGTCVAPN----KCVCPSGFTGSHCEKDIDECSEGI 557
C C G C+ C A N + +C SG + DI+EC+
Sbjct: 683 CCCASTEYAFGEPCQ-----------PCPAQNSAEYQALCSSGPGMTSAGSDINECALDP 731
Query: 558 IECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLA 617
C N C NL G Y C C SG+ D T G++C+DI+EC L + C ++ C N
Sbjct: 732 DICPN-GICENLRGTYKCICNSGYEVDST----GKNCVDINECVLNSLLC-DNGQCRNTP 785
Query: 618 GGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRC--SVCSCKDGKIFCRRTACDCQN 675
G F C CP G D LK + + C VC G C ++ +
Sbjct: 786 GSFVCTCPKGFIYKPD------LKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLD 839
Query: 676 PSADLFCCPEC------DTRVTSQC-LDQNGHKLYRS-----GDNWTHSCQQCR----CL 719
P+ + C E T + +C ++ NG L G W C C+ C
Sbjct: 840 PTKTI--CIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICG 897
Query: 720 EG-------------EVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCL--ADNITYDIR 764
+G E + +P C N C T G +C S L I DIR
Sbjct: 898 KGYSRIKGTQCEDIDECEVFPGVCKNGLCVNT---RGSFKCQCPSGMTLDATGRICLDIR 954
Query: 765 -KTCLDSY 771
+TC Y
Sbjct: 955 LETCFLRY 962
Score = 89.7 bits (221), Expect = 1e-17
Identities = 98/366 (26%), Positives = 132/366 (36%), Gaps = 79/366 (21%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY----------- 466
C GY ++G CEDIDEC C N +CVN G ++C C G
Sbjct: 896 CGKGYSRIKGTQ--CEDIDECEVFPGVCK-NGLCVNTRGSFKCQCPSGMTLDATGRICLD 952
Query: 467 IRVDD-FSCTEHDECG---SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEG 522
IR++ F E +EC +G+H D +C C G C E
Sbjct: 953 IRLETCFLRYEDEECTLPIAGRHRMD------------ACCCSVGAAWGTEEC-----EE 995
Query: 523 CRYGGTCVAPNKCVCPSGFT------GSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCE 576
C T C GF G KDI+EC C H +C N G + C
Sbjct: 996 CPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLC-THGKCRNTIGSFKCR 1054
Query: 577 CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
C SGF D +C DIDEC + C C+N G F+C C G +
Sbjct: 1055 CDSGFALDS----EERNCTDIDECRISPDLC-GRGQCVNTPGDFECKCDEG--------Y 1101
Query: 637 EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVT-SQCL 695
E G + + ++ + C+ + CR C S C P S C+
Sbjct: 1102 ESG-------FMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACI 1154
Query: 696 DQNGHKLYRSGDNWTHSCQQCRC--LEGEVDC-----WPLTCPNLSC---EYTAILEGEC 745
D N +L H C RC L G+ C + T L C + +I+ G C
Sbjct: 1155 DINECELS------AHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC 1208
Query: 746 CPRCVS 751
C +
Sbjct: 1209 ETFCTN 1214
Score = 87.4 bits (215), Expect = 5e-17
Identities = 89/315 (28%), Positives = 118/315 (37%), Gaps = 79/315 (25%)
Query: 460 CDCVPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G I CGS +C+ + + C C+ GY+G T C +
Sbjct: 100 CTCPSGQIA---------PSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIG--THCGQP 148
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDI----------DECSEGI---IECHNHS 564
CE GC GG CVAPN+C C GFTG CE+D ++ +G I C
Sbjct: 149 VCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTL 208
Query: 565 RCVNL-PGWYH-CE--------CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACI 614
C + W H CE CR GF ++ +C D+DEC C + CI
Sbjct: 209 CCATVGRAWGHPCEMCPAQPHPCRRGF----IPNIRTGACQDVDECQAIPGLCQGGN-CI 263
Query: 615 NLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQ 674
N G F+C CP+G H + K + CS G C +C
Sbjct: 264 NTVGSFECKCPAG--------------HKLNEVSQKCEDIDECSTIPG--ICE--GGECT 305
Query: 675 NPSADLFC-CPE--CDTRVTSQCLDQNGHKLYRSGDNWTHSCQ--------QCRCLEGEV 723
N + FC CP + ++C+D Y + N S Q QC C G
Sbjct: 306 NTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGR- 364
Query: 724 DCW-------PLTCP 731
CW P CP
Sbjct: 365 -CWSPGVTVAPEMCP 378
Score = 60.5 bits (145), Expect = 6e-09
Identities = 76/306 (24%), Positives = 101/306 (33%), Gaps = 55/306 (17%)
Query: 335 CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNF 394
C G K L G + + CR G MC P Q C +
Sbjct: 67 CCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMC----------TCPSGQIAPSCGSRSI 116
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
+C C + + C C+ GYI CE C CV
Sbjct: 117 QHCNIRCMNGGSCSDDH----CLCQKGYIGTHCGQPVCES---------GCLNGGRCV-- 161
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTI 514
RC C G+ E D N +C + G CT T+
Sbjct: 162 -APNRCACTYGFTGPQ----CERDYRTGPCFTVISNQMCQGQLSGIVCT--------KTL 208
Query: 515 CRAFCEEGCRYGGTC----VAPNKC---VCPSGFTGSHCEKDIDECSEGIIECHNHSRCV 567
C A G +G C P+ C P+ TG+ C+ D+DEC + I C+
Sbjct: 209 CCA--TVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGA-CQ-DVDEC-QAIPGLCQGGNCI 263
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
N G + C+C +G H S + C DIDEC+ C C N + C CP G
Sbjct: 264 NTVGSFECKCPAG-HKLNEVS---QKCEDIDECSTIPGIC-EGGECTNTVSSYFCKCPPG 318
Query: 628 PSCSGD 633
S D
Sbjct: 319 FYTSPD 324
Score = 52.4 bits (124), Expect = 2e-06
Identities = 72/284 (25%), Positives = 97/284 (34%), Gaps = 40/284 (14%)
Query: 268 HCEKTCQVSGLLYRD----QDSWVDGDHCRNCTCKSGA------VECRRMSCPPLNCSPD 317
HC C G D Q ++ G HC C+SG V R +C P
Sbjct: 118 HCNIRCMNGGSCSDDHCLCQKGYI-GTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQ 176
Query: 318 SLPVHIAGQCCKVCRPKCIYGGKVLAEGQR---ILTKS-CRECRGGVLVKITEMCPPLNC 373
+ G C V + + +GQ + TK+ C G EMCP
Sbjct: 177 CERDYRTGPCFTVISNQ-------MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPH 229
Query: 374 SEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE 433
+ +P N C+ + C P + C N C+C +G+ + S CE
Sbjct: 230 PCRRGFIP-NIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGH-KLNEVSQKCE 287
Query: 434 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG-YIRVDDFSCTEHDECGSGQHNCDENAI 492
DIDEC+ C C N Y C C PG Y D C D + N
Sbjct: 288 DIDECSTIPGICEGGE-CTNTVSSYFCKCPPGFYTSPDGTRCI--DVRPGYCYTALTNGR 344
Query: 493 CTNTVQGHSCTCKPGYVGNGTICRAFCEEG-CRYGGTCVAPNKC 535
C+N + P + C C+ G C G VAP C
Sbjct: 345 CSNQL--------PQSITKMQCC---CDAGRCWSPGVTVAPEMC 377
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/95 (31%), Positives = 38/95 (40%), Gaps = 4/95 (4%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C CG + C N C C +G+ + S C+DI+EC + C
Sbjct: 2605 CVDENECLSAHICG-GASCHNTLGSYKCMCPAGF-QYEQFSGGCQDINECGSAQAPCSYG 2662
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSG 483
C N G Y C C PGY R+ C G G
Sbjct: 2663 --CSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRG 2695
Score = 44.3 bits (103), Expect = 5e-04
Identities = 35/132 (26%), Positives = 49/132 (37%), Gaps = 21/132 (15%)
Query: 481 GSGQHNCDENA-ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPS 539
G G H+ + +C + + C G C C G C PN C CPS
Sbjct: 46 GGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCG-DGFCSRPNMCTCPS 104
Query: 540 GFTGSHC-EKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTY---------SL 589
G C + I C+ I C N C + HC C+ G+ GT+ L
Sbjct: 105 GQIAPSCGSRSIQHCN---IRCMNGGSCSD----DHCLCQKGY--IGTHCGQPVCESGCL 155
Query: 590 SGESCIDIDECA 601
+G C+ + CA
Sbjct: 156 NGGRCVAPNRCA 167
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 148 bits (373), Expect = 2e-35
Identities = 166/670 (24%), Positives = 238/670 (35%), Gaps = 178/670 (26%)
Query: 271 KTCQVSGL-LYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN---CSPDSLPVHIA- 324
K CQ L + + S G+ C CK V+CR + CPP+ C PDS +
Sbjct: 220 KVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRL 279
Query: 325 ----------------------------------------GQCCKV------CRPKCIYG 338
G+CC V +P C++
Sbjct: 280 TADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFN 339
Query: 339 GKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCA 396
+G +CR CR GGV + T C +NC + +PE +CC VC +
Sbjct: 340 NVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCER--YYVPEGECCPVCEDPVY-- 395
Query: 397 EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDID--ECAAKMHYCHANTVC--- 451
+N A C +G I GD +D +C +C A TVC
Sbjct: 396 ------------PFNNPAGCYA-NGLILAHGDRWREDDCTFCQCVNGERHCVA-TVCGQT 441
Query: 452 ----VNLPGLYRCDCV-PGYIRVDDFSCTEHDECGSGQHNC------DENA--------- 491
V +PG C P I VD +C E C +C D N
Sbjct: 442 CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINT 501
Query: 492 --ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC--VCPSGFTGSHCE 547
+C+ QG + C G++ + C CE CR P C CP G +
Sbjct: 502 EELCSERKQGCTLNCPFGFLTDAQNCE-ICE--CRPRPKKCRPIICDKYCPLGLLKNKHG 558
Query: 548 KDIDECSEGIIECHNHSRCVNLP--------GWYHCECRSGFHDDGTYSLSGESCIDIDE 599
DI C + C S P G C+CR G LSG +C+ +D
Sbjct: 559 CDICRCKK----CPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSG-TCLTVDG 613
Query: 600 CALRTHTCWNDSA--CINLAGGFDCL---CPSG-------------PSCSGD-------- 633
+ W+D C L G C CP PSC+ D
Sbjct: 614 HHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPEL 673
Query: 634 -----CPHEGGLKH-NGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADL-FCC 683
C GG G+ W + D C+ C+C G++ C C CQNPS CC
Sbjct: 674 STPSICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCC 731
Query: 684 PEC-----------DTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCP 731
P+C + V + C + G ++ + ++W C C C++ + C+ +CP
Sbjct: 732 PQCTDQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSCICIDSVISCFSESCP 790
Query: 732 NLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC 791
++SCE + +G+CCP C+ D T + C S G + W + CT C
Sbjct: 791 SVSCERPVLRKGQCCPYCIED-------TIPKKVVCHFS-GKAYADEERWDL--DSCTHC 840
Query: 792 KCKNGRVCCS 801
C G+ CS
Sbjct: 841 YCLQGQTLCS 850
Score = 115 bits (289), Expect = 1e-25
Identities = 136/562 (24%), Positives = 198/562 (35%), Gaps = 109/562 (19%)
Query: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR 332
C + + Y D D + D+CR C C+ G C C +NC +P G+CC VC
Sbjct: 336 CVFNNVEYYDGDMF-RMDNCRFCRCQGGVAICFTAQCGEINCERYYVP---EGECCPVCE 391
Query: 333 PK---------CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEK--DHILP 381
C G +LA G R C C+ V C C + + +
Sbjct: 392 DPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQ---CVNGERHCVATVCGQTCTNPVKV 448
Query: 382 ENQCCRVCRGHNFCA-EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE--- 437
+CC VC + P CGE S C T +C +G+ C+ I+
Sbjct: 449 PGECCPVCEEPTIITVDPPACGELSNC----TLTGKDCINGFKRDHNGCRTCQCINTEEL 504
Query: 438 CAAKMHYCHANT---VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG--SGQHNCDENAI 492
C+ + C N + C+C P + C ++ G +H CD I
Sbjct: 505 CSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCD---I 561
Query: 493 CT-NTVQGHSCT--CKPGYVGNG---TICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHC 546
C SC+ C G+ + IC+ C E G + C+ G H
Sbjct: 562 CRCKKCPELSCSKICPLGFQQDSHGCLICK--CREASASAGPPILSGTCLTVDG----HH 615
Query: 547 EKDIDECSEGIIECH---NHSRCVNL---------PGWYHCECRSGFHDD---------- 584
K+ + +G EC+ C + P + +C DD
Sbjct: 616 HKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELST 675
Query: 585 --------GTYSLSGESCIDIDECA----------LRTHTCWNDSACINLAGGFDCLCPS 626
G Y + GE+ +ID C T C C N + D CP
Sbjct: 676 PSICHAPGGEYFVEGETW-NIDSCTQCTCHSGRVLCETEVC-PPLLCQNPSRTQDSCCPQ 733
Query: 627 ------GPSCSGD------CPH-EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC-- 671
PS S + C + EG + + W K D C+ C C D I C +C
Sbjct: 734 CTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESW--KPDVCTSCICIDSVISCFSESCPS 791
Query: 672 -DCQNPSADLF-CCPEC-DTRVTSQCLDQNGHKLYRSGDNWT-HSCQQCRCLEGEVDCWP 727
C+ P CCP C + + + + K Y + W SC C CL+G+ C
Sbjct: 792 VSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCST 851
Query: 728 LTCPNLSCEYTAILEGECCPRC 749
++CP L C +EG CCP C
Sbjct: 852 VSCPPLPCVEPINVEGSCCPMC 873
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/147 (27%), Positives = 53/147 (36%), Gaps = 29/147 (19%)
Query: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLP 320
LS CH G + + ++W + D C CTC SG V C CPPL C P
Sbjct: 673 LSTPSICHAP-----GGEYFVEGETW-NIDSCTQCTCHSGRVLCETEVCPPLLCQN---P 723
Query: 321 VHIAGQCCKVC-----RPKCIYGGKV-------------LAEGQRILTKSCRECRGGVLV 362
CC C RP V AE + + C V+
Sbjct: 724 SRTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVIS 783
Query: 363 KITEMCPPLNCSEKDHILPENQCCRVC 389
+E CP ++C +L + QCC C
Sbjct: 784 CFSESCPSVSCERP--VLRKGQCCPYC 808
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 145 bits (366), Expect = 1e-34
Identities = 93/299 (31%), Positives = 131/299 (43%), Gaps = 45/299 (15%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAY------CEDIDECAAKMHYCH 446
N C + C + C N C CK G++S G + + C+DIDEC+ C
Sbjct: 33 NNCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCG 92
Query: 447 ANTVCVNLPGLYRCDCVPGYI----------RVDDFSCTEHDECGSGQHNCDENAICTNT 496
N+ C NL G Y+C C+ G+ + +FSCT+ +EC + C E++ C N+
Sbjct: 93 PNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSS-VCPEHSDCVNS 151
Query: 497 VQGHSCTCKPGYVGNGTICRAFCE----EGCRYGGTC---VAPNKCVCPSGFTGS----- 544
+ +SC+C+ G++ + C E C TC V C C GF S
Sbjct: 152 MGSYSCSCQVGFISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLS 211
Query: 545 ------HCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDG---TYSLSGESCI 595
CE DIDEC+E C +S C N PG Y C C GF ++ G C
Sbjct: 212 FQGLKASCE-DIDECTE---MCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECR 267
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSCSGDCPHEGGLKHNGQVWTLKED 652
DIDEC TC +S C N G + C C +G P+ G +G ++ KED
Sbjct: 268 DIDECRQDPSTCGPNSICTNALGSYSCGCIAGFHPNPEGS-QKDGNFSCQRVLFKCKED 325
Score = 99.4 bits (246), Expect = 1e-20
Identities = 66/203 (32%), Positives = 88/203 (43%), Gaps = 40/203 (19%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C C E+S+C N +C C+ G+IS ++ CED+DEC A C +
Sbjct: 130 CTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFIS---RNSTCEDVDEC-ADPRACPEH 185
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDF--------SCTEHDECGSGQHNCDENAICTNTVQGH 500
C N G Y C C PG+ SC + DEC C N+ CTNT +
Sbjct: 186 ATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDEC---TEMCPINSTCTNTPGSY 242
Query: 501 SCTCKPGYV-GNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIE 559
CTC PG+ NG + F ++G +C +DIDEC +
Sbjct: 243 FCTCHPGFAPSNGQL--NFTDQGV----------EC------------RDIDECRQDPST 278
Query: 560 CHNHSRCVNLPGWYHCECRSGFH 582
C +S C N G Y C C +GFH
Sbjct: 279 CGPNSICTNALGSYSCGCIAGFH 301
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 144 bits (362), Expect = 4e-34
Identities = 124/426 (29%), Positives = 166/426 (38%), Gaps = 84/426 (19%)
Query: 394 FCAEGPKCGENSECKN--WNTKAT--CECKSGYISVQGDSAYCEDIDECAAKMHYCHANT 449
FCA+ +C + C + N T C C G +++ D C+DIDECA H CHA
Sbjct: 5104 FCADEDECAAGNPCSHSCHNAMGTYYCSCPKG-LTIAADGRTCQDIDECALGRHTCHAGQ 5162
Query: 450 VCVNLPGLYRC--DCVPGYIRVDD-FSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
C N G YRC C G+ R D SC + +EC Q + + C N + C C+P
Sbjct: 5163 DCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC---QESSPCHQRCFNAIGSFHCGCEP 5219
Query: 507 GYVGNGTICRAF--CEEG-CRYGGTCVAPN---KCV--CPSGFTGSHCEK--DIDECSEG 556
GY G C C + CR C KC+ CP+G T + DIDEC +G
Sbjct: 5220 GYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDG 5279
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINL 616
+C + C N G Y C C G+ G G C+DI+EC C + C N
Sbjct: 5280 THQCRYNQICENTRGSYRCVCPRGYRSQGV----GRPCMDINECEQVPKPCAHQ--CSNT 5333
Query: 617 AGGFDCLCPSGPSCSGDCPHEGGLK----------------------------------- 641
G F C+CP G GD GL+
Sbjct: 5334 PGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSH 5393
Query: 642 --------HNGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADLFCCPEC-DTR 689
N + + R +C +G T D C+N A C EC +T
Sbjct: 5394 LYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDA---CQHECKNTF 5450
Query: 690 VTSQCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWP-LTCPNLSCEYTAILEGECCP 747
+ QC+ G++L +G +CQ CLE V C P C N+ Y I + C P
Sbjct: 5451 GSYQCICPPGYQLTHNG----KTCQDIDECLEQNVHCGPNRMCFNMRGSYQCI-DTPCPP 5505
Query: 748 RCVSDP 753
DP
Sbjct: 5506 NYQRDP 5511
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 141 bits (356), Expect = 2e-33
Identities = 162/631 (25%), Positives = 215/631 (34%), Gaps = 142/631 (22%)
Query: 259 TRLSQLENCH-----CEKTCQVSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPL 312
+ L+ LE+C C C G + W GD CR C C G ++CR+ C L
Sbjct: 174 SELNCLESCTPPGECCPICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASL 233
Query: 313 NCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKS-CRECR--GGVLVKITEMCP 369
C + P + G CC VC C G+ G+ + + C CR G + CP
Sbjct: 234 -CPYPARP--LPGTCCPVC-DGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCP 289
Query: 370 PLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDS 429
P+ C I QCC VC G + + E + C C++G +S +
Sbjct: 290 PVPCRHPGKI--PGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQE 347
Query: 430 AYCEDIDECAAKMHYCHAN--------------------TVCVNLPGLYRCDCV------ 463
A+ C A T CV G+ +C V
Sbjct: 348 CPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAP 407
Query: 464 -------PGYIRVDDFSCTEHDEC-GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 515
PG SCT H + +GQ+ D ++ C H+C C+ G V T
Sbjct: 408 CQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTV---TCS 458
Query: 516 RAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGII----ECHNHSR-----C 566
C P C P G C + D E + E +H R C
Sbjct: 459 LVDCP-----------PTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQEC 507
Query: 567 VNLPGWYHCECRSGFHDDGTYSLSGESCI-DIDECALR----------THTCWNDSACIN 615
G HC+ R + L G C D CA H C
Sbjct: 508 RCQEGHAHCQPRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRC 567
Query: 616 LAGGFDCL-------------------CPSGPSCSGDCPHEGGLKHNGQVW-TLKEDRCS 655
L+G CL CP P+ +G CP G Q + + D C
Sbjct: 568 LSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAPAG-CPRPGAAHARHQEYFSPPGDPCR 626
Query: 656 VCSCKDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNW--- 709
C C DG + C+R C C +P CCP CD CL Q K + SG+ +
Sbjct: 627 RCLCLDGSVSCQRLPCPPAPCAHPRQGP-CCPSCDG-----CLYQG--KEFASGERFPSP 678
Query: 710 THSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLD 769
T +C C C EG V C P C C + A G+CCP C D C +
Sbjct: 679 TAACHLCLCWEGSVSCEPKACAPALCPFPA--RGDCCPDC--DGC--------------E 720
Query: 770 SYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 800
G S LS + PC C C G V C
Sbjct: 721 YLGESYLSNQEFPDPREPCNLCTCLGGFVTC 751
Score = 134 bits (338), Expect = 3e-31
Identities = 151/571 (26%), Positives = 213/571 (37%), Gaps = 96/571 (16%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVDGDH-CRNCTCKSGAVECRRMSCPPLNCS-PDSLPVHIA 324
C +C +Y + ++ D D C C C+ G V C + CPP C+ P S P
Sbjct: 419 CPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGP---- 474
Query: 325 GQCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECR--GGVLVKITEMCPPLNCSEKDHIL 380
GQCC C P CI +V +G+ C+ECR G CP C+ H L
Sbjct: 475 GQCCPRC-PDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCA---HPL 530
Query: 381 PENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAA 440
P C C G F + G + + + C C SG + +C A
Sbjct: 531 PGTCCPNDCSGCAFGGKEYPSGADFPHPS-DPCRLCRCLSGNV-------------QCLA 576
Query: 441 KMHYCHANTVCVNLPGLYRCDC-VPGYIRVDDFSCTEHDECGSGQHNCDENAICTN-TVQ 498
+ V LPG C P + H E S + +C + +V
Sbjct: 577 RRCVPLPCPEPVLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVS 636
Query: 499 GHSCTCKPG---YVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSE 555
C P + G C + +GC Y G A + PS H + C E
Sbjct: 637 CQRLPCPPAPCAHPRQGPCCPSC--DGCLYQGKEFASGERF-PSPTAACH----LCLCWE 689
Query: 556 GIIECHNHSRCVNL---PGWYHC--ECRSGFHDDGTYSLSGESCIDIDECALRTHTCWND 610
G + C + L P C +C DG L GES + E C
Sbjct: 690 GSVSCEPKACAPALCPFPARGDCCPDC------DGCEYL-GESYLSNQEFPDPREPC--- 739
Query: 611 SACINLAGGFDC-------------LCPSG---PSCSGDCPHEGGLKHNGQVWTLKED-R 653
+ C L G C L PSG P+C G C + G +G+ D
Sbjct: 740 NLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQG-CRYHGVTTASGETLPDPLDPT 798
Query: 654 CSVCSCKDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWT 710
CS+C+C++G + C++ C C +PS CP C + ++ Q+G + +
Sbjct: 799 CSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQDGEEF----EGPA 854
Query: 711 HSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDS 770
SC+ CRC G+V C L CP L C+ G CCPRC + CL +
Sbjct: 855 GSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRC---------------RGCL-A 898
Query: 771 YGVSRLSGSVWTMAGSPCTTCKCKNGRVCCS 801
+G GS W S C++C C G V C+
Sbjct: 899 HGEEHPEGSRWVPPDSACSSCVCHEGVVTCA 929
Score = 132 bits (332), Expect = 1e-30
Identities = 153/567 (26%), Positives = 206/567 (36%), Gaps = 97/567 (17%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQC 327
HC + C +G Y + +++ D C C C +GAV+C+ SC LNC P G+C
Sbjct: 134 HC-RGCSQNGQTYGNGETF-SPDACTTCRCLTGAVQCQGPSCSELNCLESCTP---PGEC 188
Query: 328 CKVCRPKCIYGGKVLAEGQRILTKS--CRECR---GGVLVKITEMCPPLNCSEKDHILPE 382
C +C C GG GQ T CR CR G + + E C L C LP
Sbjct: 189 CPIC---CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE-CASL-CPYPARPLP- 242
Query: 383 NQCCRVCRGHNFCAEGPKCGEN-------SECKNWNTKATCE--------CKS-GYISVQ 426
CC VC G + GE S C+ N CE C+ G I Q
Sbjct: 243 GTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQ 302
Query: 427 GDSAYCEDIDECAAKMH-YCHANTVCVNLPGL-YRCDCVPGYIRVDDFSC--TEHDECGS 482
C D C + H Y T + GL RC C G + ++ C T S
Sbjct: 303 ----CCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 358
Query: 483 GQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRA-FCEEGC-RYGGTCVAPNKCVCPSG 540
G+ C + G + +G C A C++G + G P C P+
Sbjct: 359 GRQLCPACEL-----DGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQ 413
Query: 541 FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYH-CECRSGFHDDGTYSLSGESCIDIDE 599
G+ C D C+ N + H C C+ DGT + S C
Sbjct: 414 PPGACCPS-CDSCTYHSQVYANGQNFTDADSPCHACHCQ-----DGTVTCSLVDC----- 462
Query: 600 CALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC 659
+ C G CP P DC E + +G+ ++ D C C C
Sbjct: 463 ---------PPTTCARPQSGPGQCCPRCP----DCILEEEVFVDGESFSHPRDPCQECRC 509
Query: 660 KDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS---C 713
++G C+ C C +P C +C S C G K Y SG ++ H C
Sbjct: 510 QEGHAHCQPRPCPRAPCAHPLPGTCCPNDC-----SGCAF--GGKEYPSGADFPHPSDPC 562
Query: 714 QQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGV 773
+ CRCL G V C C L C +L GECCP+C P A C
Sbjct: 563 RLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQC---PAPAG---------CPRPGAA 610
Query: 774 SRLSGSVWTMAGSPCTTCKCKNGRVCC 800
++ G PC C C +G V C
Sbjct: 611 HARHQEYFSPPGDPCRRCLCLDGSVSC 637
Score = 124 bits (312), Expect = 3e-28
Identities = 141/601 (23%), Positives = 199/601 (33%), Gaps = 162/601 (26%)
Query: 258 ETRLSQLENCHCEKT---CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNC 314
+TR+ QLE+C C C G + + W + D C C C+ GA +C
Sbjct: 78 QTRVRQLESCECHPASPQCWGLGRAWPEGARW-EPDACTACVCQDGAA----------HC 126
Query: 315 SPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLN 372
P + H G C G+ G+ +C CR G + C LN
Sbjct: 127 GPQAHLPHCRG---------CSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELN 177
Query: 373 CSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKA----TCECKSGYISVQGD 428
C E P +CC +C C EG E+ + W T C C G+I +
Sbjct: 178 CLES--CTPPGECCPIC-----CTEGGSHWEHGQ--EWTTPGDPCRICRCLEGHIQCRQ- 227
Query: 429 SAYCEDIDECAAKMHYCH---ANTVCVNLPGLY-------------------RCDCVPGY 466
ECA+ Y T C G + C C G
Sbjct: 228 -------RECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGS 280
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTN-TVQGHS-----------------CTCKPGY 508
++ + C G+ +C QGH C+C+ G
Sbjct: 281 VQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGE 340
Query: 509 VGNGTICRAFCEEGCRYGGTCVAP--NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRC 566
V CEE C P + +CP+ CE D +E +EG+ + C
Sbjct: 341 VS--------CEEQECPVTPCALPASGRQLCPA------CELDGEEFAEGVQWEPDGRPC 386
Query: 567 VNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPS 626
C C+ G G C H AC CPS
Sbjct: 387 T------ACVCQDGVPKCGAVLCPPAPC---------QHPTQPPGAC----------CPS 421
Query: 627 GPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC---DCQNP-SADLFC 682
SC+ + + NGQ +T + C C C+DG + C C C P S C
Sbjct: 422 CDSCT----YHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQC 477
Query: 683 CPECDTRVTSQCLDQNGHKLYRSGDNWTH---SCQQCRCLEGEVDCWPLTCPNLSCEYTA 739
CP C + + +++ G++++H CQ+CRC EG C P CP C +
Sbjct: 478 CPRCPDCILEE-------EVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHP- 529
Query: 740 ILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 799
L G CCP S G SG+ + PC C+C +G V
Sbjct: 530 -LPGTCCPNDCSGCAFG---------------GKEYPSGADFPHPSDPCRLCRCLSGNVQ 573
Query: 800 C 800
C
Sbjct: 574 C 574
Score = 100 bits (249), Expect = 5e-21
Identities = 130/518 (25%), Positives = 183/518 (35%), Gaps = 118/518 (22%)
Query: 273 CQVSGLLYRDQDSWVDG-DHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
C+ G Y + D + C CTC G V C R C P CS +P +G CC C
Sbjct: 719 CEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIP---SGHCCPTC 775
Query: 332 RPKCIYGGKVLAEGQRI---LTKSCR--ECRGGVLVKITEMCPPLNCSEKDHILPENQCC 386
+ C Y G A G+ + L +C C+ G + + CPP C H P C
Sbjct: 776 QG-CRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCP---HPSPGPCFC 831
Query: 387 RVCRGHNFCAEGPKCGENSECKN-WNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYC 445
VC H+ ++G + + E + + C C++G +S
Sbjct: 832 PVC--HSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVS--------------------- 868
Query: 446 HANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCK 505
CV L +C +P ++V TE C C C + H
Sbjct: 869 -----CVRL----QCPPLPCKLQV-----TERGSC------CPRCRGCLAHGEEHP---- 904
Query: 506 PGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSR 565
EG R+ A + CVC G + I C++ H
Sbjct: 905 ---------------EGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQP--RQGPHDC 947
Query: 566 CVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC--------ALRTHTCWNDSACINLA 617
C P CE ++ G G ++ C +LR H C +L
Sbjct: 948 C---PQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHR----RQCPSLV 1000
Query: 618 GGFDC----LCPSGPS-CSGDCPHEGGLKHNGQVWT--LKEDRCSVCSCKDGKIFCRRTA 670
G C L P GP C C G + + D C C C+D C A
Sbjct: 1001 G---CPPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQA 1057
Query: 671 C-DCQNPSADLF-----CCPECDTRVTSQCLDQNGHKLYRSGDNWT-HSCQQCRCLEGEV 723
C + P ++ CCP C T C+ Q + SG+ WT +C C C+ G V
Sbjct: 1058 CPELSCPLSERHTPPGSCCPVCRAP-TQSCVHQG--REVASGERWTVDTCTSCSCMAGTV 1114
Query: 724 DCWPLTCPNLSC---EYTAILEGECCPRCVSDP--CLA 756
C C LSC + A+ G CCPRC+ P C+A
Sbjct: 1115 RCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRPASCMA 1152
Score = 100 bits (248), Expect = 7e-21
Identities = 92/319 (28%), Positives = 120/319 (37%), Gaps = 55/319 (17%)
Query: 494 TNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG-GTCVAPNKCVCPSGFTGSHCEKDIDE 552
T Q SC C P + RA+ EG R+ C A CVC G +HC
Sbjct: 79 TRVRQLESCECHPASPQCWGLGRAW-PEGARWEPDACTA---CVCQDG--AAHCGPQ--- 129
Query: 553 CSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSA 612
+LP C + +G + S ++C C C S
Sbjct: 130 --------------AHLPHCRGCSQNGQTYGNGE-TFSPDACTTC-RCLTGAVQCQGPS- 172
Query: 613 CINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD 672
C L C P G C C G +GQ WT D C +C C +G I CR+ C
Sbjct: 173 CSELNCLESCT-PPGECCPICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECA 231
Query: 673 --CQNPSADL--FCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL 728
C P+ L CCP CD + ++G + SGD C CRC G V C PL
Sbjct: 232 SLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGD----PCSHCRCANGSVQCEPL 286
Query: 729 TCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC-LDSYGVSRLSGSVWTMAGSP 787
CP + C + + G+CCP C D C Y ++T L G+
Sbjct: 287 PCPPVPCRHPGKIPGQCCPVC--DGCEYQGHQYQSQETFRLQERGL-------------- 330
Query: 788 CTTCKCKNGRVCCSVDFEC 806
C C C+ G V C + EC
Sbjct: 331 CVRCSCQAGEVSCE-EQEC 348
Score = 99.8 bits (247), Expect = 9e-21
Identities = 132/552 (23%), Positives = 185/552 (33%), Gaps = 97/552 (17%)
Query: 289 GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRI 348
GD CR C C G+V C+R+ CPP C+ G CC C C+Y GK A G+R
Sbjct: 622 GDPCRRCLCLDGSVSCQRLPCPPAPCAHPR-----QGPCCPSC-DGCLYQGKEFASGERF 675
Query: 349 L--TKSCRECRGGVLVKITEMCPPLNCSEKDHILP-ENQCCRVCRGHNFCAEGPKCGENS 405
T +C C + + + C P C+ P CC C G + E N
Sbjct: 676 PSPTAACHLC---LCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYL--SNQ 730
Query: 406 ECKNWNTKAT-CECKSGYISV-------QGDSAYCEDIDECAAKMHYCHANTVCVNLPGL 457
E + C C G+++ G S C C + V
Sbjct: 731 EFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTASG-- 788
Query: 458 YRCDCVPGYIRVDDFSCTEHDECGSGQHNCDEN----AICTNTVQGHSCTCKPGYVGNGT 513
+ +P + CT C G C + A+C + G C C
Sbjct: 789 ---ETLPDPLDPTCSLCT----CQEGSMRCQKKPCPPALCPHPSPG-PCFCP-------- 832
Query: 514 ICRAFC------EEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCV 567
+C + ++G + G + C C +G C + +C + R
Sbjct: 833 VCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVS--CVRL--QCPPLPCKLQVTERGS 888
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLA----GGFDCL 623
P C H +G+ + +S C TC + A G DC
Sbjct: 889 CCPRCRGCLAHGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCC 948
Query: 624 CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDG-----KIFCRRTACD----CQ 674
P CS DC HEG G+ + D C VC C+ + C R C C
Sbjct: 949 ----PQCS-DCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCP 1003
Query: 675 N----PSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTC 730
P CCP C ++ L L S C C+C + C C
Sbjct: 1004 PSQLLPPGPQHCCPTC-----AEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQAC 1058
Query: 731 PNLSCEYTA--ILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPC 788
P LSC + G CCP C + ++C+ G SG WT+ C
Sbjct: 1059 PELSCPLSERHTPPGSCCPVCRAPT-----------QSCVHQ-GREVASGERWTV--DTC 1104
Query: 789 TTCKCKNGRVCC 800
T+C C G V C
Sbjct: 1105 TSCSCMAGTVRC 1116
Score = 82.8 bits (203), Expect = 1e-15
Identities = 93/339 (27%), Positives = 123/339 (36%), Gaps = 74/339 (21%)
Query: 501 SCTCKPGYVG-NGTICRAF-CEEGCRYGGTCVAPNKCVCPSGFTGSHCEKD--------- 549
+C C G V G C C E C G C C G GSH E
Sbjct: 158 TCRCLTGAVQCQGPSCSELNCLESCTPPGECCP---ICCTEG--GSHWEHGQEWTTPGDP 212
Query: 550 --IDECSEGIIECHNHSRCVNL--------PGWYHCECRSGFHDDGTYSLSGESCIDIDE 599
I C EG I+C C +L PG C G +G SGE D
Sbjct: 213 CRICRCLEGHIQCRQRE-CASLCPYPARPLPGTC-CPVCDGCFLNGREHRSGEPVGSGDP 270
Query: 600 CALRTHT-CWNDSA-CINL-AGGFDCLCPSG------PSCSGDCPHEGGLKHNGQVWTLK 650
C+ H C N S C L C P P C G C ++G + + + L+
Sbjct: 271 CS---HCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDG-CEYQGHQYQSQETFRLQ 326
Query: 651 E-DRCSVCSCKDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSG 706
E C CSC+ G++ C C C P++ CP C+ +G + + G
Sbjct: 327 ERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPACEL---------DGEE-FAEG 376
Query: 707 DNWT---HSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDI 763
W C C C +G C + CP C++ G CCP C D C + Y
Sbjct: 377 VQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSC--DSCTYHSQVY-- 432
Query: 764 RKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSV 802
+G +T A SPC C C++G V CS+
Sbjct: 433 ------------ANGQNFTDADSPCHACHCQDGTVTCSL 459
Score = 57.0 bits (136), Expect = 7e-08
Identities = 48/183 (26%), Positives = 68/183 (37%), Gaps = 16/183 (8%)
Query: 257 AETRLSQLENCHCEKTCQVSGLLYRDQDSWVDG-DHCRNCTCKSG-----AVECRRMSCP 310
A+ R + C C+ G Y +S+ G D C C C+ ++ C R CP
Sbjct: 938 AQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCP 997
Query: 311 PL-NCSPDSLPVHIAGQCCKVCRP---KCIYG--GKVLAEGQRILTKSCRECRGGVLVKI 364
L C P L CC C C G G LA T C++ + I
Sbjct: 998 SLVGCPPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDL---TWLCI 1054
Query: 365 TEMCPPLNCSEKDHILPENQCCRVCRG-HNFCAEGPKCGENSECKNWNTKATCECKSGYI 423
+ CP L+C + P CC VCR C + + E +T +C C +G +
Sbjct: 1055 HQACPELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTV 1114
Query: 424 SVQ 426
Q
Sbjct: 1115 RCQ 1117
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/138 (25%), Positives = 55/138 (39%), Gaps = 25/138 (18%)
Query: 221 PNLNHTCPTCSDFLS-LVQGIMD---------------------LQELLAKMTAKLNYAE 258
P H CPTC++ LS +G++ + + +++ L+
Sbjct: 1010 PGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERH 1069
Query: 259 TRL-SQLENCHC-EKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSP 316
T S C ++C G + W D C +C+C +G V C+ C PL+C P
Sbjct: 1070 TPPGSCCPVCRAPTQSCVHQGREVASGERWT-VDTCTSCSCMAGTVRCQSQRCSPLSCGP 1128
Query: 317 DSLPVHIAGQCCKVCRPK 334
D P G CC C P+
Sbjct: 1129 DKAPALSPGSCCPRCLPR 1146
Score = 50.1 bits (118), Expect = 8e-06
Identities = 41/150 (27%), Positives = 63/150 (42%), Gaps = 26/150 (17%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAG 325
CH +C G ++D + + C C C++G V C R+ CPPL C L V G
Sbjct: 834 CH---SCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPC---KLQVTERG 887
Query: 326 QCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECRGGVLVKITEMCPPLNCSEKDHILPEN 383
CC CR C+ G+ EG R + +C C V + C + C +
Sbjct: 888 SCCPRCR-GCLAHGEEHPEGSRWVPPDSACSSC---VCHEGVVTCARIQCI--------S 935
Query: 384 QCCRVCRGHNFCAEGPKCGENSECKNWNTK 413
C + +G + C C + S+C++ K
Sbjct: 936 SCAQPRQGPHDC-----CPQCSDCEHEGRK 960
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 139 bits (349), Expect = 1e-32
Identities = 145/591 (24%), Positives = 204/591 (34%), Gaps = 150/591 (25%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQC 327
HC + C +G Y + +++ D C C C G + C + CP C G C
Sbjct: 134 HC-RGCSQNGQTYGNGETF-SPDACTTCRCLEGTITCNQKPCPRGPCPEP-------GAC 184
Query: 328 CKVCRPKCIYGGKVLAEGQRILTKS--CREC---RGGVLVKITEMCPPLNCSEKDHILPE 382
C C+P C Y G++ EG L+ S C +C R V + CPP C E +L
Sbjct: 185 CPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALK-CPPSPCPEP--VLRP 241
Query: 383 NQCCRVCRGHNFCAEGPKCGENSECKNWNTKA----TCECKSGYISVQGDSAYCEDIDEC 438
CC C+G C EG E+ + W T C C G+I + EC
Sbjct: 242 GHCCPTCQG---CTEGGSHWEHGQ--EWTTPGDPCRICRCLEGHIQCRQ--------REC 288
Query: 439 AAKMHYCH---ANTVCVNLPGLY-------------------RCDCVPGYIRVDDFSCTE 476
A+ Y T C G + C C G ++ + C
Sbjct: 289 ASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPP 348
Query: 477 HDECGSGQHNCDENAICTN-TVQGHS-----------------CTCKPGYVGNGTICRAF 518
G+ +C QGH C+C+ G V
Sbjct: 349 VPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVS-------- 400
Query: 519 CEEGCRYGGTCVAP--NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCE 576
CEE C P + +CP+ CE D +E +EG+ + C C
Sbjct: 401 CEEQECPVTPCALPASGRQLCPA------CELDGEEFAEGVQWEPDGRPCT------ACV 448
Query: 577 CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
C+ G G C H AC CPS SC+ +
Sbjct: 449 CQDGVPKCGAVLCPPAPC---------QHPTQPPGAC----------CPSCDSCT----Y 485
Query: 637 EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC---DCQNP-SADLFCCPECDTRVTS 692
+ NGQ +T + C C C+DG + C C C P S CCP C +
Sbjct: 486 HSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILE 545
Query: 693 QCLDQNGHKLYRSGDNWTH---SCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRC 749
+ +++ G++++H CQ+CRC EG C P CP C + L G CCP
Sbjct: 546 E-------EVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHP--LPGTCCPND 596
Query: 750 VSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 800
S G SG+ + PC C+C +G V C
Sbjct: 597 CSGCAFG---------------GKEYPSGADFPHPSDPCRLCRCLSGNVQC 632
Score = 137 bits (345), Expect = 4e-32
Identities = 153/568 (26%), Positives = 204/568 (35%), Gaps = 91/568 (16%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDH-CRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326
HC+ C G LY + +++ + C CTC V C + CPP SP PV G
Sbjct: 187 HCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPP---SPCPEPVLRPGH 243
Query: 327 CCKVCRPKCIYGGKVLAEGQRILTKS--CRECR---GGVLVKITEMCPPLNCSEKDHILP 381
CC C+ C GG GQ T CR CR G + + E C L C LP
Sbjct: 244 CCPTCQG-CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE-CASL-CPYPARPLP 300
Query: 382 ENQCCRVCRGHNFCAEGPKCGEN-------SECKNWNTKATCE--------CKS-GYISV 425
CC VC G + GE S C+ N CE C+ G I
Sbjct: 301 -GTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPG 359
Query: 426 QGDSAYCEDIDECAAKMH-YCHANTVCVNLPGL-YRCDCVPGYIRVDDFSC--TEHDECG 481
Q C D C + H Y T + GL RC C G + ++ C T
Sbjct: 360 Q----CCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPA 415
Query: 482 SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRA-FCEEGC-RYGGTCVAPNKCVCPS 539
SG+ C + G + +G C A C++G + G P C P+
Sbjct: 416 SGRQLCPACEL-----DGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPT 470
Query: 540 GFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYH-CECRSGFHDDGTYSLSGESCIDID 598
G+ C D C+ N + H C C+ DGT + S C
Sbjct: 471 QPPGACCPS-CDSCTYHSQVYANGQNFTDADSPCHACHCQ-----DGTVTCSLVDC---- 520
Query: 599 ECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCS 658
+ C G CP P DC E + +G+ ++ D C C
Sbjct: 521 ----------PPTTCARPQSGPGQCCPRCP----DCILEEEVFVDGESFSHPRDPCQECR 566
Query: 659 CKDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS--- 712
C++G C+ C C +P C +C S C G K Y SG ++ H
Sbjct: 567 CQEGHAHCQPRPCPRAPCAHPLPGTCCPNDC-----SGCAF--GGKEYPSGADFPHPSDP 619
Query: 713 CQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYG 772
C+ CRCL G V C C L C +L GECCP+C + P A C
Sbjct: 620 CRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAG---------CPRPGA 670
Query: 773 VSRLSGSVWTMAGSPCTTCKCKNGRVCC 800
++ G PC C C +G V C
Sbjct: 671 AHARHQEYFSPPGDPCRRCLCLDGSVSC 698
Score = 132 bits (333), Expect = 1e-30
Identities = 148/572 (25%), Positives = 197/572 (34%), Gaps = 127/572 (22%)
Query: 268 HCEKTCQ---VSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHI 323
HC TCQ G + W GD CR C C G ++CR+ C L C + P +
Sbjct: 243 HCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASL-CPYPARP--L 299
Query: 324 AGQCCKVCRPKCIYGGKVLAEGQRILTKS-CRECR--GGVLVKITEMCPPLNCSEKDHIL 380
G CC VC C G+ G+ + + C CR G + CPP+ C I
Sbjct: 300 PGTCCPVC-DGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI- 357
Query: 381 PENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAA 440
QCC VC G + + E + C C++G +S + A+
Sbjct: 358 -PGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 416
Query: 441 KMHYCHAN--------------------TVCVNLPGLYRCDCV-------------PGYI 467
C A T CV G+ +C V PG
Sbjct: 417 GRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGAC 476
Query: 468 RVDDFSCTEHDEC-GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG 526
SCT H + +GQ+ D ++ C H+C C+ G V T C
Sbjct: 477 CPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTV---TCSLVDCP------ 521
Query: 527 GTCVAPNKCVCPSGFTGSHCEKDIDECSEGII----ECHNHSR-----CVNLPGWYHCEC 577
P C P G C + D E + E +H R C G HC+
Sbjct: 522 -----PTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQP 576
Query: 578 RSGFHDDGTYSLSGESCI-DIDECALR----------THTCWNDSACINLAGGFDCL--- 623
R + L G C D CA H C L+G CL
Sbjct: 577 RPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARR 636
Query: 624 -------------------CPSGPSCSGDCPHEGGLKHNGQVW-TLKEDRCSVCSCKDGK 663
CP+ P+ +G CP G Q + + D C C C DG
Sbjct: 637 CVPLPCPEPVLLPGECCPQCPAAPAPAG-CPRPGAAHARHQEYFSPPGDPCRRCLCLDGS 695
Query: 664 IFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNW---THSCQQCR 717
+ C+R C C +P CCP CD CL Q K + SG+ + T +C C
Sbjct: 696 VSCQRLPCPPAPCAHPRQGP-CCPSCDG-----CLYQG--KEFASGERFPSPTAACHLCL 747
Query: 718 CLEGEVDCWPLTCPNLSCEYTAILEGECCPRC 749
C EG V C P C C + A G+CCP C
Sbjct: 748 CWEGSVSCEPKACAPALCPFPA--RGDCCPDC 777
Score = 101 bits (251), Expect = 3e-21
Identities = 92/334 (27%), Positives = 123/334 (36%), Gaps = 71/334 (21%)
Query: 501 SCTCKPGYVGNGTI-----CRAFCEEGCRYG-GTCVAPNKCVCPSGFTGSHCEKDIDECS 554
+C C+ G G CR + G YG G +P+ C C C
Sbjct: 116 ACVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTT--------CR-----CL 162
Query: 555 EGIIECHNHSRCVN----LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWND 610
EG I C N C PG C+ G +G G + + L+ +
Sbjct: 163 EGTITC-NQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSR 221
Query: 611 SACINLAGGFDCLCPSGP-------------SCSGDCPHEGGLKHNGQVWTLKEDRCSVC 657
C+ L CP P +C G C G +GQ WT D C +C
Sbjct: 222 VRCMALK------CPPSPCPEPVLRPGHCCPTCQG-CTEGGSHWEHGQEWTTPGDPCRIC 274
Query: 658 SCKDGKIFCRRTACD--CQNPSADL--FCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSC 713
C +G I CR+ C C P+ L CCP CD + ++G + SGD C
Sbjct: 275 RCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGD----PC 329
Query: 714 QQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC-LDSYG 772
CRC G V C PL CP + C + + G+CCP C D C Y ++T L G
Sbjct: 330 SHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVC--DGCEYQGHQYQSQETFRLQERG 387
Query: 773 VSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFEC 806
+ C C C+ G V C + EC
Sbjct: 388 L--------------CVRCSCQAGEVSCE-EQEC 406
Score = 89.7 bits (221), Expect = 1e-17
Identities = 134/576 (23%), Positives = 193/576 (33%), Gaps = 167/576 (28%)
Query: 258 ETRLSQLENCHCEKT---CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNC 314
+TR+ QLE+C C C G + + W + D C C C+ GA +C
Sbjct: 78 QTRVRQLESCECHPASPQCWGLGRAWPEGARW-EPDACTACVCQDGAA----------HC 126
Query: 315 SPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLN 372
P + H G C G+ G+ +C CR G + + CP
Sbjct: 127 GPQAHLPHCRG---------CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGP 177
Query: 373 CSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYC 432
C E CC P C K C+ + G + +G
Sbjct: 178 CPEP------GACC------------PHC-----------KPGCDYE-GQLYEEG----- 202
Query: 433 EDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAI 492
+ + ++ C+ +C C+ +R C C E +
Sbjct: 203 ---------VTFLSSSNPCL------QCTCLRSRVRCMALKCPPSP--------CPEPVL 239
Query: 493 CTNTVQGHSC-TCKPGYVGNGTICRAFCEEGCRYGGT-CVAPNKCVCPSGFTGSHCEKDI 550
GH C TC +GC GG+ + P G C I
Sbjct: 240 RP----GHCCPTC----------------QGCTEGGSHWEHGQEWTTP----GDPCR--I 273
Query: 551 DECSEGIIECHNHSRCVNL--------PGWYHCECRSGFHDDGTYSLSGESCIDIDECAL 602
C EG I+C C +L PG C G +G SGE D C+
Sbjct: 274 CRCLEGHIQCRQRE-CASLCPYPARPLPGTC-CPVCDGCFLNGREHRSGEPVGSGDPCS- 330
Query: 603 RTHT-CWNDSA-CINL-AGGFDCLCPSG------PSCSGDCPHEGGLKHNGQVWTLKE-D 652
H C N S C L C P P C G C ++G + + + L+E
Sbjct: 331 --HCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDG-CEYQGHQYQSQETFRLQERG 387
Query: 653 RCSVCSCKDGKIFCRRTACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNW 709
C CSC+ G++ C C C P++ CP C+ +G + + G W
Sbjct: 388 LCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPACEL---------DGEE-FAEGVQW 437
Query: 710 T---HSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKT 766
C C C +G C + CP C++ G CCP C D C + Y
Sbjct: 438 EPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSC--DSCTYHSQVY----- 490
Query: 767 CLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSV 802
+G +T A SPC C C++G V CS+
Sbjct: 491 ---------ANGQNFTDADSPCHACHCQDGTVTCSL 517
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/106 (33%), Positives = 47/106 (44%), Gaps = 12/106 (11%)
Query: 289 GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRI 348
GD CR C C G+V C+R+ CPP C+ G CC C C+Y GK A G+R
Sbjct: 683 GDPCRRCLCLDGSVSCQRLPCPPAPCAHPR-----QGPCCPSC-DGCLYQGKEFASGERF 736
Query: 349 --LTKSCRECRGGVLVKITEMCPPLNCSEKDHILP-ENQCCRVCRG 391
T +C C + + + C P C+ P CC C G
Sbjct: 737 PSPTAACHLC---LCWEGSVSCEPKACAPALCPFPARGDCCPDCDG 779
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/141 (31%), Positives = 57/141 (40%), Gaps = 21/141 (14%)
Query: 265 ENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCS-PDSLPVHI 323
++C +G + D DS C C+ G V C + CPP C+ P S P
Sbjct: 481 DSCTYHSQVYANGQNFTDADSPCHA-----CHCQDGTVTCSLVDCPPTTCARPQSGP--- 532
Query: 324 AGQCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECR--GGVLVKITEMCPPLNCSEKDHI 379
GQCC C P CI +V +G+ C+ECR G CP C+ H
Sbjct: 533 -GQCCPRC-PDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCA---HP 587
Query: 380 LPENQCCRVCRGHNFCAEGPK 400
LP C C G CA G K
Sbjct: 588 LPGTCCPNDCSG---CAFGGK 605
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 135 bits (340), Expect = 2e-31
Identities = 122/453 (26%), Positives = 174/453 (38%), Gaps = 83/453 (18%)
Query: 398 GPKCGEN-SECKNWNTKATCECKSGYISV------QGDSAYC-EDIDECAAKMHYCHANT 449
G C EN +C N K C G + + YC ED+DEC + C
Sbjct: 251 GQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGG 310
Query: 450 VCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C N G Y C CV G+ D C+E+ D+C S C A C + V C C G
Sbjct: 311 TCHNTHGGYNCVCVNGWTGED---CSENIDDCASAA--CFHGATCHDRVASFYCECPHGR 365
Query: 509 VGNGTICR---AFCEEGCRYGGTCVAPNK-----CVCPSGFTGSHCEKDIDECSEGIIEC 560
G +C A C G C C CPSG+TG C +D+DECS G C
Sbjct: 366 TG--LLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423
Query: 561 HNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLAGG 619
+ +C+N G + C+C G+ +G C ID++EC ++ C ND+ C++ G
Sbjct: 424 EHAGKCINTLGSFECQCLQGY--------TGPRCEIDVNECV--SNPCQNDATCLDQIGE 473
Query: 620 FDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC-KDGKIF--CRRTACDCQNP 676
F C+C G + G + D C+ C +G+ C+C
Sbjct: 474 FQCICMPG--------------YEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTG 519
Query: 677 SADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG------EVD---CWP 727
C + D ++ C +NG K + +T C C EG EVD C P
Sbjct: 520 FTGHLCQYDVDECASTPC--KNGAKCLDGPNTYT-----CVCTEGYTGTHCEVDIDECDP 572
Query: 728 LTCPNLSCE-----YTAILE----GECCP----RCVSDPCLADNITYDIRKTCLDSYGVS 774
C SC+ +T + G C C S PC D R + +
Sbjct: 573 DPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQD-RDNAYLCFCLK 631
Query: 775 RLSGSVWTMAGSPCTTCKCKNGRVCCSVD-FEC 806
+G + C + C +G +D +EC
Sbjct: 632 GTTGPNCEINLDDCASSPCDSGTCLDKIDGYEC 664
Score = 121 bits (304), Expect = 2e-27
Identities = 118/423 (27%), Positives = 167/423 (39%), Gaps = 107/423 (25%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVN 453
C G +C ++ + ++++ C C +G+ QG + CE DI+EC + C C N
Sbjct: 838 CRNGGECRQSEDYESFS----CVCPTGW---QGQT--CEVDINECV--LSPCRHGASCQN 886
Query: 454 LPGLYRCDCVPGYIRVDDFSC-TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG 512
G YRC C GY +C T+ D+C C CT+ + C C PG+ G
Sbjct: 887 THGGYRCHCQAGY---SGRNCETDIDDCRPNP--CHNGGSCTDGINTAFCDCLPGFRGT- 940
Query: 513 TICRAFCEEG--------CRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECSEGIIECH 561
FCEE CR G C V C CP+GF+G HCE + +C+E C
Sbjct: 941 -----FCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES--SCF 993
Query: 562 NHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLAGGF 620
N CV+ + C C GF +G C D++EC + C + C + G +
Sbjct: 994 NGGTCVDGINSFTCLCPPGF--------TGSYCQHDVNEC--DSQPCLHGGTCQDGCGSY 1043
Query: 621 DCLCP---SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKD-GKIFCRRT--ACDCQ 674
C CP +GP+C L H W C CK+ GK + T C+C
Sbjct: 1044 RCTCPQGYTGPNCQ-------NLVH----W------CDSSPCKNGGKCWQTHTQYRCECP 1086
Query: 675 NPSADLFC---CPECDTRVTSQCLD-----QNGHKLYRSGDNWTHSCQQCRCLEGEV--- 723
+ L+C C+ Q +D Q+G +G+ TH CRC G
Sbjct: 1087 SGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGN--TH---HCRCQAGYTGSY 1141
Query: 724 ------DCWPLTCPN----------LSCEYTAILEGECC----PRCVSDPCLADNITYDI 763
+C P C N SC+ A G C C+S PC D+
Sbjct: 1142 CEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDL 1201
Query: 764 RKT 766
T
Sbjct: 1202 PNT 1204
Score = 119 bits (298), Expect = 1e-26
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 86/434 (19%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGD--SAYCEDIDECAA--KMHYCHAN 448
++C P C +C +T+ CEC SG+ + D S CE + C
Sbjct: 1061 HWCDSSP-CKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHG 1119
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
+CV+ + C C GY + DEC C A CT+ + G+SC C GY
Sbjct: 1120 GLCVDAGNTHHCRCQAGY--TGSYCEDLVDECSPSP--CQNGATCTDYLGGYSCKCVAGY 1175
Query: 509 VGNGTICRAFCEE----GCRYGGTCV-APN--KCVCPSGFTGSHCEKDIDECSEGI---- 557
+G C +E C+ GGTC+ PN KC CP G G HCE ++D+C+ +
Sbjct: 1176 --HGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVS 1233
Query: 558 --IECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI-DIDECALRTHTCWNDSACI 614
+C N+ CV+ G Y C C GF GE C D++EC C+
Sbjct: 1234 RSPKCFNNGTCVDQVGGYSCTCPPGF--------VGERCEGDVNECLSNPCDARGTQNCV 1285
Query: 615 NLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQ 674
F C C +G H G+ + C CK+G T
Sbjct: 1286 QRVNDFHCECRAG--------------HTGRRCESVINGCKGKPCKNG-----GTCAVAS 1326
Query: 675 NPSADLFC-CPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNL 733
N + C CP T +N +C RCL G P
Sbjct: 1327 NTARGFICKCPAGFEGATC--------------ENDARTCGSLRCLNGGTCISGPRSPTC 1372
Query: 734 SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKC 793
C G C S PCL N Y+ G+ + SP C C
Sbjct: 1373 LC--LGPFTGPECQFPASSPCLGGNPCYN--------------QGTCEPTSESPFYRCLC 1416
Query: 794 K---NGRVCCSVDF 804
NG +C +D+
Sbjct: 1417 PAKFNGLLCHILDY 1430
Score = 118 bits (296), Expect = 2e-26
Identities = 136/542 (25%), Positives = 189/542 (34%), Gaps = 156/542 (28%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVN 453
CA P C N C + + CEC +G+ C+ D+DECA+ C C++
Sbjct: 494 CASSP-CLHNGRCLDKINEFQCECPTGFTG-----HLCQYDVDECASTP--CKNGAKCLD 545
Query: 454 LPGLYRCDCVPGYI----RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
P Y C C GY VD C + D C G C + V +C C+PGY
Sbjct: 546 GPNTYTCVCTEGYTGTHCEVDIDEC-DPDPCHYGS--------CKDGVATFTCLCRPGYT 596
Query: 510 GNG--TICRAFCEEGCRYGGTC---------------VAPN------------------- 533
G+ T + CR+GGTC PN
Sbjct: 597 GHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCL 656
Query: 534 ------KCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTY 587
+C C G+TGS C +IDEC+ CHN C + + C C G+HD
Sbjct: 657 DKIDGYECACEPGYTGSMCNINIDECAGN--PCHNGGTCEDGINGFTCRCPEGYHDPTCL 714
Query: 588 ------------------SLSGESC----------IDIDECALRTHTCWNDSACINLAGG 619
SL+G C DI+ ++ C N C ++ G
Sbjct: 715 SEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSG 774
Query: 620 FDCLCP---SGPSC--------SGDCPHEGG-------------LKHNGQVWTLKEDRCS 655
+ C C SGP+C S C ++G L + G + C+
Sbjct: 775 YVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCA 834
Query: 656 VCSCKDGKIFCRRT------ACDCQNPSADLFCCPECDTRVTSQCLD----QNGHKLYRS 705
C++G CR++ +C C C + + V S C QN H YR
Sbjct: 835 PSPCRNGG-ECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRC 893
Query: 706 GDNWTHSCQQCRCLEGEV-DCWPLTCPN----------LSCEYTAILEGECCP----RCV 750
+S + C E ++ DC P C N C+ G C C
Sbjct: 894 HCQAGYSGRNC---ETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECA 950
Query: 751 SDPCLADNITYDIRKTCLDSYGVSRLSG--SVWTMAGSP-CTTCKCKNGRVCCS--VDFE 805
SDPC D C+DSY + +G + +P CT C NG C F
Sbjct: 951 SDPCRNGANCTD----CVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFT 1006
Query: 806 CL 807
CL
Sbjct: 1007 CL 1008
Score = 113 bits (283), Expect = 6e-25
Identities = 156/623 (25%), Positives = 219/623 (35%), Gaps = 138/623 (22%)
Query: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLP 320
L ++ CE +G L + D D C + CK+GA + C+
Sbjct: 506 LDKINEFQCECPTGFTGHLCQ-----YDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTG 560
Query: 321 VHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECRGGVLVKITEMC-PPLNC 373
H + C YG +G T CR C + ++ C C
Sbjct: 561 THCEVDIDECDPDPCHYGS--CKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTC 618
Query: 374 SEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYI--SVQGDSAY 431
++D+ +C FC +G G N E N + A+ C SG + G
Sbjct: 619 QDRDN-------AYLC----FCLKG-TTGPNCEI-NLDDCASSPCDSGTCLDKIDGYECA 665
Query: 432 CE----------DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
CE +IDECA + CH C + + C C GY D +E +EC
Sbjct: 666 CEPGYTGSMCNINIDECAG--NPCHNGGTCEDGINGFTCRCPEGY--HDPTCLSEVNECN 721
Query: 482 SGQHNCDENAICTNTVQGHSCTCKPGYVG-NGTICRAFCEEG-CRYGGTC---VAPNKCV 536
S N + C +++ G+ C C PG+ G N I CE C GGTC + C
Sbjct: 722 S---NPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778
Query: 537 CPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCE-------------------- 576
C GF+G +C+ +I+EC+ C N C++ Y C
Sbjct: 779 CREGFSGPNCQTNINECASN--PCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPS 836
Query: 577 -CRSG-----FHDDGTYSL------SGESC-IDIDECALRTHTCWNDSACINLAGGFDCL 623
CR+G D ++S G++C +DI+EC L C + ++C N GG+ C
Sbjct: 837 PCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVL--SPCRHGASCQNTHGGYRCH 894
Query: 624 CP---SGPSCSGDCPH-EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSAD 679
C SG +C D HNG SC DG CDC
Sbjct: 895 CQAGYSGRNCETDIDDCRPNPCHNGG------------SCTDG---INTAFCDCLPGFRG 939
Query: 680 LFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSC----QQCRCLEGEVDCWPLTCPNLSC 735
FC + + + C +NG D++T +C C DC +C N
Sbjct: 940 TFCEEDINECASDPC--RNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGT 997
Query: 736 EYTAILEGEC-CP-------------RCVSDPCLADNITYD----IRKTCLDSYGVSRLS 777
I C CP C S PCL D R TC Y
Sbjct: 998 CVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQ 1057
Query: 778 GSV-WTMAGSPCTTCKCKNGRVC 799
V W C + CKNG C
Sbjct: 1058 NLVHW------CDSSPCKNGGKC 1074
Score = 108 bits (270), Expect = 2e-23
Identities = 116/465 (24%), Positives = 174/465 (37%), Gaps = 115/465 (24%)
Query: 392 HNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTV 450
+N C P C CK+ + C C+ G+ C+ +I+ECA+ + C
Sbjct: 754 NNECESNP-CVNGGTCKDMTSGYVCTCREGF-----SGPNCQTNINECAS--NPCLNQGT 805
Query: 451 CVNLPGLYRCDCVPGYIRV--------------------------DDFSC---------- 474
C++ Y+C+C+ Y + FSC
Sbjct: 806 CIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQT 865
Query: 475 --TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE----GCRYGGT 528
+ +EC C A C NT G+ C C+ GY G C ++ C GG+
Sbjct: 866 CEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGYSGRN--CETDIDDCRPNPCHNGGS 921
Query: 529 C---VAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDG 585
C + C C GF G+ CE+DI+EC+ C N + C + Y C C +GF
Sbjct: 922 CTDGINTAFCDCLPGFRGTFCEEDINECASD--PCRNGANCTDCVDSYTCTCPAGF---- 975
Query: 586 TYSLSGESC-IDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNG 644
SG C + +C +C+N C++ F CLCP G + S C H+
Sbjct: 976 ----SGIHCENNTPDCT--ESSCFNGGTCVDGINSFTCLCPPGFTGS-YCQHD------- 1021
Query: 645 QVWTLKEDRCSVC----SCKDGKIFCRRTACDCQNPSADLFCCPECDTRV----TSQCLD 696
+ E C +C+DG C C C + P C V +S C
Sbjct: 1022 ----VNECDSQPCLHGGTCQDG---CGSYRCTCPQG----YTGPNCQNLVHWCDSSPC-- 1068
Query: 697 QNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDP--C 754
+NG K ++ TH+ +C C G + P++SCE A +G R C
Sbjct: 1069 KNGGKCWQ-----THTQYRCECPSGWTGLY-CDVPSVSCEVAAQRQGVDVARLCQHGGLC 1122
Query: 755 LADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 799
+ T+ R C Y +GS C+ C+NG C
Sbjct: 1123 VDAGNTHHCR--CQAGY-----TGSYCEDLVDECSPSPCQNGATC 1160
Score = 84.7 bits (208), Expect = 3e-16
Identities = 122/520 (23%), Positives = 179/520 (34%), Gaps = 133/520 (25%)
Query: 396 AEGPKCGENSE-------CKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
A GP+C + E C+ N C C ++ + C+D + C +
Sbjct: 19 ARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPR-----CQDPNPCLSTPCKNAGT 73
Query: 449 TVCVNLPGL--YRCDCVPGY-----IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHS 501
V+ G+ Y C C G+ + D +C + C +G CD T+ +
Sbjct: 74 CHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNP-CRNGG-TCD-----LLTLTEYK 126
Query: 502 CTCKPGYVGNGTICRAFCEEG-CRYGGTCV---APNKCVCPSGFTGSHCEKDIDECSEGI 557
C C PG+ G C C GG C+ A C CP F G C +D++EC +
Sbjct: 127 CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKP 186
Query: 558 IECHNHSRCVNLPGWYHCECR-----------------SGFHDDGTYSLSGE-----SCI 595
C + C N G Y C CR S + GT +G+ +C+
Sbjct: 187 GLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACL 246
Query: 596 ----------DIDECALRTHTCWNDSACINLAGGFDCLCP---SGPSCSGDCP------- 635
+ID+C + C N AC++ ++C CP +G C+ D
Sbjct: 247 PGFTGQNCEENIDDCP--GNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPN 304
Query: 636 --HEGGLKHNG---------QVWTLKE-----DRCSVCSCKDGKIFCRRTA---CDCQNP 676
GG HN WT ++ D C+ +C G R A C+C +
Sbjct: 305 ACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHG 364
Query: 677 SADLFC----------CPE---CDTRVTSQCLDQNGHKLYRSGDNWT-HSCQQ--CRCLE 720
L C C E CDT NG + +T +C Q C
Sbjct: 365 RTGLLCHLNDACISNPCNEGSNCDTNPV------NGKAICTCPSGYTGPACSQDVDECSL 418
Query: 721 GEVDCWPL-----TCPNLSCEYTAILEGECCP----RCVSDPCLADNITYD----IRKTC 767
G C T + C+ G C CVS+PC D D + C
Sbjct: 419 GANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCIC 478
Query: 768 LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSV-DFEC 806
+ Y + A SPC NGR + +F+C
Sbjct: 479 MPGYEGVHCEVNTDECASSPC----LHNGRCLDKINEFQC 514
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 135 bits (339), Expect = 2e-31
Identities = 124/469 (26%), Positives = 173/469 (36%), Gaps = 111/469 (23%)
Query: 382 ENQCCRV----CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYC-EDID 436
E Q C V C GH C G C + N C+C + +C ED+D
Sbjct: 229 EGQNCEVNVDDCPGHR-CLNGGTCVDGVNTYN------CQCPPEWTG-----QFCTEDVD 276
Query: 437 ECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTN 495
EC + + CH C N G + C CV G+ SC+++ D+C + C A C +
Sbjct: 277 ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGE---SCSQNIDDCATAV--CFHGATCHD 331
Query: 496 TVQGHSCTCKPGYVGNGTICR---AFCEEGCRYGGTCVAPNK-----CVCPSGFTGSHCE 547
V C C G G +C A C C C CP GFTG C+
Sbjct: 332 RVASFYCACPMGKTG--LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD 389
Query: 548 KDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHT 606
+D+DECS G C + RCVN G + C+C G+ +G C D++EC +
Sbjct: 390 QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY--------TGPRCETDVNECL--SGP 439
Query: 607 CWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFC 666
C N + C++ G F C+C +G G + D C C +G +
Sbjct: 440 CRNQATCLDRIGQFTCICMAG--------------FTGTYCEVDIDECQSSPCVNGGVCK 485
Query: 667 RRT---ACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEV 723
R +C C + + C + D ++ C +NG K D + +CRC EG
Sbjct: 486 DRVNGFSCTCPSGFSGSTCQLDVDECASTPC--RNGAKCVDQPDGY-----ECRCAEG-- 536
Query: 724 DCWPLTCPNLSCEYTAILEGECCPR----CVSDPC----LADNITYDIRKTCLDSYGVSR 775
EG C R C DPC D I C Y +R
Sbjct: 537 -----------------FEGTLCDRNVDDCSPDPCHHGRCVDGIA-SFSCACAPGYTGTR 578
Query: 776 LSGSVWTMAGSPCT------------TCKCKNGR--VCCSVDF-ECLQN 809
V PC C+C +G V C V+ +C N
Sbjct: 579 CESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
Score = 127 bits (320), Expect = 3e-29
Identities = 117/437 (26%), Positives = 163/437 (37%), Gaps = 74/437 (16%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
CA G +C + + C C GY QG S D+DEC H T C+N
Sbjct: 128 CAHGARCSVGPD-----GRFLCSCPPGY---QGRSCR-SDVDECRVGEPCRHGGT-CLNT 177
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQ-GHSCTCKPGYVGNGT 513
PG +RC C GY E+ C C + + C C PG+ G
Sbjct: 178 PGSFRCQCPAGYTG----PLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN- 232
Query: 514 ICRAFCEE----GCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRC 566
C ++ C GGTC V C CP +TG C +D+DEC CHN C
Sbjct: 233 -CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTC 291
Query: 567 VNLPGWYHCECRSGFHDDGTYSLSGESCI-DIDECALRTHTCWNDSACINLAGGFDCLCP 625
N G + C C +G+ +GESC +ID+CA T C++ + C + F C CP
Sbjct: 292 FNTLGGHSCVCVNGW--------TGESCSQNIDDCA--TAVCFHGATCHDRVASFYCACP 341
Query: 626 SG---------PSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNP 676
G +C + HE + V + ++C+C G ACD
Sbjct: 342 MGKTGLLCHLDDACVSNPCHEDAICDTNPV-----NGRAICTCPPG---FTGGACDQDVD 393
Query: 677 SADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPN---- 732
+ P C+ +C++ G L + G +T RC +C C N
Sbjct: 394 ECSIGANP-CEH--LGRCVNTQGSFLCQCGRGYTGP----RCETDVNECLSGPCRNQATC 446
Query: 733 ------LSCEYTAILEGECC----PRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWT 782
+C A G C C S PC+ + D R S SGS
Sbjct: 447 LDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKD-RVNGFSCTCPSGFSGSTCQ 505
Query: 783 MAGSPCTTCKCKNGRVC 799
+ C + C+NG C
Sbjct: 506 LDVDECASTPCRNGAKC 522
Score = 104 bits (259), Expect = 4e-22
Identities = 137/524 (26%), Positives = 184/524 (35%), Gaps = 117/524 (22%)
Query: 285 SWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCK--VC-------RPKC 335
S VDG++ C C G S PPL C P S P A + C +C R C
Sbjct: 671 SCVDGENGFRCLCPPG-------SLPPL-CLPPSHPC--AHEPCSHGICYDAPGGFRCVC 720
Query: 336 IYGGKVLAEGQRILTKSCRE--CRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHN 393
G Q + +C CR G M C P R C +
Sbjct: 721 EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTC-------PPGVQGRQCELLS 773
Query: 394 FCAEGPKCGENSECKNWNTKA-TCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
C P C C++ + C C G+ QG +D+DECA C + +C
Sbjct: 774 PCTPNP-CEHGGRCESAPGQLPVCSCPQGW---QGPRCQ-QDVDECAGPAP-CGPHGICT 827
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAI-----CTNTVQGHSCTCKPG 507
NL G + C C GY C ++CD N C + V SC+C PG
Sbjct: 828 NLAGSFSCTCHGGYTG---------PSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPG 878
Query: 508 YVGNGTICRAFCEEGCRYG----GTC---VAPNKCVCPSGFTGSHCEKDIDECSEGIIEC 560
+ G C +E C GTC VA C CP G+ G HCE+D+ +CS C
Sbjct: 879 FAGPR--CARDVDE-CLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPS--SC 933
Query: 561 HNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLAGG 619
N CV+ + C CR G+ +G C + D C R C + C G
Sbjct: 934 FNGGTCVDGVNSFSCLCRPGY--------TGAHCQHEADPCLSR--PCLHGGVCSAAHPG 983
Query: 620 FDCLCP---SGPSCS--------GDCPHEGGLKHNGQVWTLKEDRCSVCSCKDG--KIFC 666
F C C +GP C C + G G + C C G C
Sbjct: 984 FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTG----------AYCLCPPGWSGRLC 1033
Query: 667 RRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVD- 724
+ C+ +A + E + QC+D++ + T S C+Q EVD
Sbjct: 1034 DIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQ------EVDP 1087
Query: 725 CWPLTCPN----------LSCEYTAILEGECC----PRCVSDPC 754
C C + CE G+ C C S PC
Sbjct: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
Score = 100 bits (248), Expect = 7e-21
Identities = 141/595 (23%), Positives = 195/595 (32%), Gaps = 163/595 (27%)
Query: 268 HCEKT---CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIA 324
HCE+ C S + + VDG + +C C+ G +C H A
Sbjct: 920 HCEQDLPDCSPSSCF--NGGTCVDGVNSFSCLCRPGYTGA--------HCQ------HEA 963
Query: 325 GQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQ 384
C + RP C++GG A G + + C C +
Sbjct: 964 DPC--LSRP-CLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA 1020
Query: 385 CC--------RVCRGHNF-CAEGPK---------CGENSECKNWNTKATCECKSGYISVQ 426
C R+C + C E C +C + ++ C C G
Sbjct: 1021 YCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTG-- 1078
Query: 427 GDSAYCE-DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQ 484
++CE ++D C A+ C C G Y C+C+PGY + +C + DEC S
Sbjct: 1079 ---SHCEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY---NGDNCEDDVDECAS-- 1128
Query: 485 HNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF---CEEG--------CRYGGTCV--- 530
C C + V + C+C PG +G +C C G C + GTCV
Sbjct: 1129 QPCQHGGSCIDLVARYLCSCPPGTLG--VLCEINEDDCGPGPPLDSGPRCLHNGTCVDLV 1186
Query: 531 APNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLP-GWYHCECRSGFHDDGTYSL 589
+C CP G+TG CE DI+EC G + C+ P G + C C +GF ++
Sbjct: 1187 GGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV 1246
Query: 590 ----SGESCIDIDECALR-------THTC------WNDSA-----------------CIN 615
+ C +C T TC W C
Sbjct: 1247 LSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQ 1306
Query: 616 LAGGFDCLCP---SGPSC----------------SGDCPHEGGLKHN----------GQV 646
G C CP SGPSC + C H G + Q
Sbjct: 1307 TPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQG 1366
Query: 647 WTLKEDRCSVCSCK---DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLY 703
WT RC + + C R A CQ D C EC+ + C G
Sbjct: 1367 WT--GPRCEAPAAAPEVSEEPRCPRAA--CQAKRGDQRCDRECN---SPGCGWDGGDCSL 1419
Query: 704 RSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADN 758
GD W +QC L+ CW L C P C S CL DN
Sbjct: 1420 SVGDPW----RQCEALQ----CWRL-----------FNNSRCDPACSSPACLYDN 1455
Score = 95.9 bits (237), Expect = 1e-19
Identities = 126/523 (24%), Positives = 166/523 (31%), Gaps = 156/523 (29%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVN 453
C P C CK+ +C C SG+ + C+ D+DECA+ C CV+
Sbjct: 473 CQSSP-CVNGGVCKDRVNGFSCTCPSGF-----SGSTCQLDVDECASTP--CRNGAKCVD 524
Query: 454 LPGLYRCDCVPGYI------RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
P Y C C G+ VDD S D C G+ C + + SC C PG
Sbjct: 525 QPDGYECRCAEGFEGTLCDRNVDDCS---PDPCHHGR--------CVDGIASFSCACAPG 573
Query: 508 YVGNGTICRAFCEE----GCRYGGTCV--------------------------APNKC-- 535
Y G T C + +E CR+GG C+ A N C
Sbjct: 574 YTG--TRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF 631
Query: 536 ------------VCPSGFTGSHCEKDIDECS-------------EGIIEC---------- 560
VC GFTG C +I+EC+ E C
Sbjct: 632 GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPL 691
Query: 561 ------------HNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI-DIDECALRTHTC 607
+H C + PG + C C G+ SG C + A + C
Sbjct: 692 CLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGW--------SGPRCSQSLARDACESQPC 743
Query: 608 WNDSACINLAGGFDCLCPSG----------PSCSGDCPHEGGLKHNGQVWTLKEDRCSVC 657
C + GF C CP G P C H G + + VC
Sbjct: 744 RAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCES-------APGQLPVC 796
Query: 658 SCKDG--KIFCRRTACDCQNPSADLFCCPE--CDTRVTSQCLDQNGHKLYRSGDNWTHSC 713
SC G C++ +C P+ C P C S +G S D + C
Sbjct: 797 SCPQGWQGPRCQQDVDECAGPAP---CGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDC 853
Query: 714 QQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPR----CVSDPCLADNITYDIRK---T 766
CL G C + SC G C R C+S+PC T + T
Sbjct: 854 DPNPCLNGG-SCQD-GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCT 911
Query: 767 CLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCS--VDFECL 807
C YG + C+ C NG C F CL
Sbjct: 912 CPPGYGGFHCEQDL-----PDCSPSSCFNGGTCVDGVNSFSCL 949
Score = 94.7 bits (234), Expect = 3e-19
Identities = 111/441 (25%), Positives = 159/441 (36%), Gaps = 103/441 (23%)
Query: 451 CVNLPGLYR-CDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQG----HSCTCK 505
C LP C C PG++ C D C SG C +C ++V SC C
Sbjct: 55 CTQLPSREAACLCPPGWVGE---RCQLEDPCHSGP--CAGRGVCQSSVVAGTARFSCRCP 109
Query: 506 PGYVGNGTICRAFC-EEGCRYGGTC-VAPNK---CVCPSGFTGSHCEKDIDECSEGIIEC 560
G+ G C C +G C V P+ C CP G+ G C D+DEC G C
Sbjct: 110 RGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG-EPC 168
Query: 561 HNHSRCVNLPGWYHCECRSGF-------------------------HDDGTY------SL 589
+ C+N PG + C+C +G+ D TY
Sbjct: 169 RHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGF 228
Query: 590 SGESC-IDIDECALRTHTCWNDSACINLAGGFDCLCP---SGPSCSGD---CPHEGGLKH 642
G++C +++D+C H C N C++ ++C CP +G C+ D C + H
Sbjct: 229 EGQNCEVNVDDCP--GHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH 286
Query: 643 NGQV---------------WTLKE-----DRCSVCSCKDGKIFCRRTA---CDCQNPSAD 679
NG WT + D C+ C G R A C C
Sbjct: 287 NGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTG 346
Query: 680 LFCCPECDTRVTSQCLDQ--------NGHKLYRSGDNWT-HSCQQ--CRCLEGEVDCWPL 728
L C + D V++ C + NG + +T +C Q C G C L
Sbjct: 347 LLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHL 405
Query: 729 -TCPNLSCEYTAIL-EGECCPRCVSD--PCLADNITYDIRKTCLDSYG------VSRLSG 778
C N + G PRC +D CL+ + TCLD G ++ +G
Sbjct: 406 GRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRN--QATCLDRIGQFTCICMAGFTG 463
Query: 779 SVWTMAGSPCTTCKCKNGRVC 799
+ + C + C NG VC
Sbjct: 464 TYCEVDIDECQSSPCVNGGVC 484
Score = 53.1 bits (126), Expect = 1e-06
Identities = 79/309 (25%), Positives = 108/309 (34%), Gaps = 86/309 (27%)
Query: 398 GPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDEC-AAKMHYCHANTVCVNLP 455
GP+C N C + C C GY ++ CE DI+EC + H H +
Sbjct: 1173 GPRCLHNGTCVDLVGGFRCTCPPGYTGLR-----CEADINECRSGACHAAHTRDCLQDPG 1227
Query: 456 GLYRCDCVPGYIR---------VDDFSCTEHDEC------GSG----------------- 483
G +RC C G+ + C +C G G
Sbjct: 1228 GGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE 1287
Query: 484 -------QHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF------------CEEGCR 524
+ C C T +G C C PG +G CR+F C
Sbjct: 1288 RVARSCRELQCPVGVPCQQTPRGPRCACPPGL--SGPSCRSFPGSPPGASNASCAAAPCL 1345
Query: 525 YGGTC----VAP-NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHC--EC 577
+GG+C +AP +C C G+TG CE + C G C EC
Sbjct: 1346 HGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDREC 1405
Query: 578 RS---GFHDDGTYSLS-GESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSC--- 630
S G+ D G SLS G+ + AL+ +N+S C D C S P+C
Sbjct: 1406 NSPGCGW-DGGDCSLSVGDPWRQCE--ALQCWRLFNNSRC-------DPAC-SSPACLYD 1454
Query: 631 SGDCPHEGG 639
+ DC H GG
Sbjct: 1455 NFDC-HAGG 1462
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 135 bits (339), Expect = 2e-31
Identities = 117/439 (26%), Positives = 171/439 (38%), Gaps = 104/439 (23%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCT----CKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCID 596
D+DEC+ C RCVN PG + CEC++G++ DG C+D
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI----SRMCVD 399
Query: 597 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
++EC R C N G + C C G S D + E S
Sbjct: 400 VNECQ-RYPGRLCGHKCENTLGSYLCSCSVGFRLSVD---------GRSCEDINECSSSP 449
Query: 657 CSCKDGKI------FCRR---------TAC----DCQNPSADLFCCPEC-DTRVTSQC-L 695
CS + + +CRR C +C P+ C C + + QC
Sbjct: 450 CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509
Query: 696 DQNGHKLYRSGDN---------WTHSC---QQCRCLEGEVDCWPLTCPNLSCEYTAILEG 743
+G++L +G N H+C + C ++G C CP A L+
Sbjct: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQ 569
Query: 744 ECCP--RCVSDPCLADNIT 760
E RC+ C +++T
Sbjct: 570 EKTDTVRCIKS-CRPNDVT 587
Score = 104 bits (260), Expect = 3e-22
Identities = 119/450 (26%), Positives = 169/450 (37%), Gaps = 110/450 (24%)
Query: 267 CHCEKTCQV--SGLLYRDQDSWVDGDH-CR---NCTCKSGAVECRR-------------M 307
C C Q+ G+ D + + G H CR +C G+ C+R
Sbjct: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN 258
Query: 308 SCPPL--------NCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQRILTKSCRECR 357
SC + NC PD + + G CRPK C G A G I C
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINEC---- 312
Query: 358 GGVLVKITEMCP-PLNCSEKDHILPENQCCRVC-RGHNFCAEGPKCGENSECK------- 408
+ I+ CP C + + C RG++ EG +C + EC
Sbjct: 313 ----LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
Query: 409 ------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
N CECK+GY G S C D++EC + C N G Y C C
Sbjct: 369 KGHRCVNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSC 426
Query: 463 VPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE 521
G+ + VD SC + +EC S C + C N + C C+ GY +
Sbjct: 427 SVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDV-------- 474
Query: 522 GCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
G TC ++C P TG H CS RC+N+PG + C C S
Sbjct: 475 ---DGVTCEDIDECALP---TGGHI------CS---------YRCINIPGSFQCSCPSSG 513
Query: 582 HDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLK 641
+ + +G +C DIDEC H C + C N+ GGF CL + +CP
Sbjct: 514 Y---RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL-------AFECPE----N 559
Query: 642 HNGQVWTLKED-----RCSVCSCKDGKIFC 666
+ TL+++ RC + SC+ + C
Sbjct: 560 YRRSAATLQQEKTDTVRC-IKSCRPNDVTC 588
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 135 bits (339), Expect = 2e-31
Identities = 115/397 (28%), Positives = 154/397 (38%), Gaps = 78/397 (19%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C + C + C A C C GY ++ D CEDI+EC +H C CV
Sbjct: 681 NTCKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDINECVTDLHTCSRGEHCV 737
Query: 453 NLPGLYRC----DCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----TC 504
N G + C C PGY + D C + DEC G H C +C NT C C
Sbjct: 738 NTLGSFHCYKALTCEPGY-ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRC 796
Query: 505 KPGYV----GNGTICR--AFCEEGCRYGGTCV--------APNKCVCPSGF----TGSHC 546
G++ GN E CR G +C+ N +C G+ G+ C
Sbjct: 797 MDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC 856
Query: 547 EKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC-ALRTH 605
D++EC G+ C C NLPG Y C+C++GF D G CID++EC A
Sbjct: 857 -VDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDA----FGRGCIDVNECWASPGR 911
Query: 606 TCWNDSACINLAGGFDCLCPSG------------------PSCSGDCPHEGGLK--HNGQ 645
C C N G + C C SG CS +C + G + Q
Sbjct: 912 LC--QHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQ 969
Query: 646 VWTLKED--RCS-VCSCKDGK-IFCRRTACDCQNPSADLFC-CPECDTRVTS---QCLDQ 697
+ L ED C+ + C G I C C N C CPE +T+ C D
Sbjct: 970 GYQLAEDGHTCTDIDECAQGAGILC---TFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1026
Query: 698 NGHKLYRSGDNWTHSCQQ---CRCLEGEVDCWPLTCP 731
+ L TH+C + C ++G C CP
Sbjct: 1027 DECAL------GTHNCSEAETCHNIQGSFRCLRFECP 1057
Score = 134 bits (338), Expect = 3e-31
Identities = 112/362 (30%), Positives = 151/362 (41%), Gaps = 62/362 (17%)
Query: 289 GDHCRNCTCKSGAVEC-RRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQR 347
G+HC N G+ C + ++C P D G+C V +C G G
Sbjct: 733 GEHCVNTL---GSFHCYKALTCEPGYALKD-------GECEDV--DECAMGTHTCQPGFL 780
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHIL--PENQCCRVCRGHNFCAE-GPKCGEN 404
C+ +G + + C D L PE C + N C C
Sbjct: 781 -----CQNTKGSFYCQARQRC-------MDGFLQDPEGNCVDI----NECTSLSEPCRPG 824
Query: 405 SECKNWNTKATCE-----CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYR 459
C N TC+ C GY D C D++EC +H C VC NLPG YR
Sbjct: 825 FSCINTVGSYTCQRNPLICARGY-HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYR 883
Query: 460 CDCVPGYIRVDDF--SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--GNGTIC 515
CDC G+ R D F C + +EC + ++ C NT+ + C+C G++ +G C
Sbjct: 884 CDCKAGFQR-DAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRC 941
Query: 516 RAFCE-EGCRYGGTCV---APNKCVCPSGF---TGSHCEKDIDECSEGI-IECHNHSRCV 567
E E R C +C C G+ H DIDEC++G I C RC+
Sbjct: 942 EDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILC--TFRCL 999
Query: 568 NLPGWYHCEC-RSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL--- 623
N+PG Y C C G+ T + +G SC D+DECAL TH C C N+ G F CL
Sbjct: 1000 NVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE 1055
Query: 624 CP 625
CP
Sbjct: 1056 CP 1057
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/186 (30%), Positives = 74/186 (39%), Gaps = 27/186 (14%)
Query: 450 VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTC----- 504
+C+N G Y C C PG+ DD + E A+ + Q S T
Sbjct: 619 LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678
Query: 505 KPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFT----GSHCEKDIDECSEGIIEC 560
+P + C+ C GG+ + C C G+ G CE DI+EC + C
Sbjct: 679 QPNTCKDNGPCKQVCS---TVGGSAI----CSCFPGYAIMADGVSCE-DINECVTDLHTC 730
Query: 561 HNHSRCVNLPGWYHC----ECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINL 616
CVN G +HC C G Y+L C D+DECA+ THTC C N
Sbjct: 731 SRGEHCVNTLGSFHCYKALTCEPG------YALKDGECEDVDECAMGTHTCQPGFLCQNT 784
Query: 617 AGGFDC 622
G F C
Sbjct: 785 KGSFYC 790
Score = 35.8 bits (81), Expect = 0.16
Identities = 26/94 (27%), Positives = 39/94 (41%), Gaps = 8/94 (8%)
Query: 275 VSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC-R 332
V G + Q +VD G +C G + C+ M CP L P+ + + C C +
Sbjct: 79 VRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPEL--PPNCIEAVVVADSCPQCGQ 136
Query: 333 PKCIYGGKVLAEGQRILTKSCRECR----GGVLV 362
C++ G A G + CR C GG L+
Sbjct: 137 VGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELI 170
Score = 32.3 bits (72), Expect = 1.8
Identities = 23/81 (28%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 724 DCWPLTCPNL-SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDS---YGVSRLSGS 779
DC + CP L +C A+ G CC CV C + Y CL G S
Sbjct: 32 DCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQY---YDCLQGGFVRGRVPAGQS 88
Query: 780 VWTMAGSPCTTCKCKNGRVCC 800
+ GS +C G++ C
Sbjct: 89 YFVDFGSTECSCPPGGGKISC 109
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 134 bits (338), Expect = 3e-31
Identities = 112/362 (30%), Positives = 151/362 (41%), Gaps = 62/362 (17%)
Query: 289 GDHCRNCTCKSGAVEC-RRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQR 347
G+HC N G+ C + ++C P D G+C V +C G G
Sbjct: 780 GEHCVNTL---GSFHCYKALTCEPGYALKD-------GECEDV--DECAMGTHTCQPGFL 827
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHIL--PENQCCRVCRGHNFCAE-GPKCGEN 404
C+ +G + + C D L PE C + N C C
Sbjct: 828 -----CQNTKGSFYCQARQRC-------MDGFLQDPEGNCVDI----NECTSLSEPCRPG 871
Query: 405 SECKNWNTKATCE-----CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYR 459
C N TC+ C GY D C D++EC +H C VC NLPG YR
Sbjct: 872 FSCINTVGSYTCQRNPLICARGY-HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYR 930
Query: 460 CDCVPGYIRVDDF--SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--GNGTIC 515
CDC G+ R D F C + +EC + ++ C NT+ + C+C G++ +G C
Sbjct: 931 CDCKAGFQR-DAFGRGCIDVNECWASPGRLCQHT-CENTLGSYRCSCASGFLLAADGKRC 988
Query: 516 RAFCE-EGCRYGGTCV---APNKCVCPSGF---TGSHCEKDIDECSEGI-IECHNHSRCV 567
E E R C +C C G+ H DIDEC++G I C RC+
Sbjct: 989 EDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILC--TFRCL 1046
Query: 568 NLPGWYHCEC-RSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL--- 623
N+PG Y C C G+ T + +G SC D+DECAL TH C C N+ G F CL
Sbjct: 1047 NVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE 1102
Query: 624 CP 625
CP
Sbjct: 1103 CP 1104
Score = 125 bits (314), Expect = 2e-28
Identities = 120/439 (27%), Positives = 155/439 (35%), Gaps = 78/439 (17%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C + C + C A C C GY ++ D CED DEC H C CV
Sbjct: 681 NTCKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDQDECLMGAHDCSRRQFCV 737
Query: 453 NLPGLYRCD-----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----T 503
N G + C C GYI C + +EC + H C C NT+ C T
Sbjct: 738 NTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALT 797
Query: 504 CKPGY--------------VGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGS---HC 546
C+PGY +G T F + + C A +C+ GF +C
Sbjct: 798 CEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCM--DGFLQDPEGNC 855
Query: 547 EKDIDECSEGIIECHNHSRCVNLPGWYHCE-----CRSGFH--DDGTYSLSGESCIDIDE 599
DI+EC+ C C+N G Y C+ C G+H DDGT C+D++E
Sbjct: 856 V-DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT------KCVDVNE 908
Query: 600 CALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS---- 655
C H C C NL G + C C +G D G + N + W C
Sbjct: 909 CETGVHRCGEGQVCHNLPGSYRCDCKAG--FQRDAFGRGCIDVN-ECWASPGRLCQHTCE 965
Query: 656 ------VCSCKDGKIFCR-RTACDCQNPSADLFCCPECDTRVTS-QCLDQNGHKLYRSGD 707
CSC G + C+ N C EC S QC + G++L G
Sbjct: 966 NTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGH 1025
Query: 708 NWT--HSCQQ-------CRCLE--GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLA 756
T C Q RCL G C CP YT G C D C
Sbjct: 1026 TCTDIDECAQGAGILCTFRCLNVPGSYQC---ACPEQG--YTMTANGRSCKDV--DECAL 1078
Query: 757 DNITYDIRKTCLDSYGVSR 775
+TC + G R
Sbjct: 1079 GTHNCSEAETCHNIQGSFR 1097
Score = 123 bits (308), Expect = 8e-28
Identities = 116/422 (27%), Positives = 155/422 (36%), Gaps = 95/422 (22%)
Query: 386 CRVCRGHNFCAEGPKCGENSEC------------------KNWNTKATCECKSGYISVQG 427
C G+ A+G C + EC + T C GYI
Sbjct: 702 CSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYI--LN 759
Query: 428 DSAYCEDIDECAAKMHYCHANTVCVNLPGLYRC----DCVPGYIRVDDFSCTEHDECGSG 483
C DI+EC +H C CVN G + C C PGY + D C + DEC G
Sbjct: 760 AHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY-ALKDGECEDVDECAMG 818
Query: 484 QHNCDENAICTNTVQGHSC----TCKPGYV----GNGTICR--AFCEEGCRYGGTCV--- 530
H C +C NT C C G++ GN E CR G +C+
Sbjct: 819 THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 878
Query: 531 -----APNKCVCPSGF----TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
N +C G+ G+ C D++EC G+ C C NLPG Y C+C++GF
Sbjct: 879 GSYTCQRNPLICARGYHASDDGTKC-VDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 937
Query: 582 HDDGTYSLSGESCIDIDEC-ALRTHTCWNDSACINLAGGFDCLCPSG------------- 627
D G CID++EC A C C N G + C C SG
Sbjct: 938 QRDA----FGRGCIDVNECWASPGRLC--QHTCENTLGSYRCSCASGFLLAADGKRCEDV 991
Query: 628 -----PSCSGDCPHEGGLK--HNGQVWTLKED--RCS-VCSCKDGK-IFCRRTACDCQNP 676
CS +C + G + Q + L ED C+ + C G I C C N
Sbjct: 992 NECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILC---TFRCLNV 1048
Query: 677 SADLFC-CPECDTRVTS---QCLDQNGHKLYRSGDNWTHSCQQ---CRCLEGEVDCWPLT 729
C CPE +T+ C D + L TH+C + C ++G C
Sbjct: 1049 PGSYQCACPEQGYTMTANGRSCKDVDECAL------GTHNCSEAETCHNIQGSFRCLRFE 1102
Query: 730 CP 731
CP
Sbjct: 1103 CP 1104
Score = 76.6 bits (187), Expect = 8e-14
Identities = 67/261 (25%), Positives = 94/261 (36%), Gaps = 48/261 (18%)
Query: 450 VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTC----- 504
+C+N G Y C C PG+ DD + E A+ + Q S T
Sbjct: 619 LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678
Query: 505 KPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFT----GSHCEKDIDECSEGIIEC 560
+P + C+ C GG+ + C C G+ G CE D DEC G +C
Sbjct: 679 QPNTCKDNGPCKQVCST---VGGSAI----CSCFPGYAIMADGVSCE-DQDECLMGAHDC 730
Query: 561 HNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGF 620
CVN G ++C + DG + C+DI+EC HTC C+N G F
Sbjct: 731 SRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSF 790
Query: 621 DC----LCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRC-SVCSCKDGKIFCRRTACDCQN 675
C C G + LK+ C V C G C + CQN
Sbjct: 791 HCYKALTCEPG-------------------YALKDGECEDVDECAMGTHTC-QPGFLCQN 830
Query: 676 PSADLFCCPECDTRVTSQCLD 696
+C + +C+D
Sbjct: 831 TKGSFYC------QARQRCMD 845
Score = 35.8 bits (81), Expect = 0.16
Identities = 26/94 (27%), Positives = 39/94 (41%), Gaps = 8/94 (8%)
Query: 275 VSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC-R 332
V G + Q +VD G +C G + C+ M CP L P+ + + C C +
Sbjct: 79 VRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPEL--PPNCIEAVVVADSCPQCGQ 136
Query: 333 PKCIYGGKVLAEGQRILTKSCRECR----GGVLV 362
C++ G A G + CR C GG L+
Sbjct: 137 VGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELI 170
Score = 32.3 bits (72), Expect = 1.8
Identities = 23/81 (28%), Positives = 31/81 (38%), Gaps = 7/81 (8%)
Query: 724 DCWPLTCPNL-SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDS---YGVSRLSGS 779
DC + CP L +C A+ G CC CV C + Y CL G S
Sbjct: 32 DCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQY---YDCLQGGFVRGRVPAGQS 88
Query: 780 VWTMAGSPCTTCKCKNGRVCC 800
+ GS +C G++ C
Sbjct: 89 YFVDFGSTECSCPPGGGKISC 109
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 133 bits (334), Expect = 8e-31
Identities = 110/408 (26%), Positives = 159/408 (38%), Gaps = 101/408 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCT----CKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCID 596
D+DEC+ C RCVN PG + CEC++G++ DG C+D
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI----SRMCVD 399
Query: 597 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
++EC R C N G + C C G S D + E S
Sbjct: 400 VNECQ-RYPGRLCGHKCENTLGSYLCSCSVGFRLSVD---------GRSCEDINECSSSP 449
Query: 657 CSCKDGKI------FCRR---------TAC----DCQNPSADLFCCPEC-DTRVTSQC-L 695
CS + + +CRR C +C P+ C C + + QC
Sbjct: 450 CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509
Query: 696 DQNGHKLYRSGDN---------WTHSC---QQCRCLEGEVDCWPLTCP 731
+G++L +G N H+C + C ++G C CP
Sbjct: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 107 bits (268), Expect = 3e-23
Identities = 121/444 (27%), Positives = 164/444 (36%), Gaps = 97/444 (21%)
Query: 267 CHCEKTCQV--SGLLYRDQDSWVDGDH-CR---NCTCKSGAVECRR-------------M 307
C C Q+ G+ D + + G H CR +C G+ C+R
Sbjct: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN 258
Query: 308 SCPPL--------NCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQRILTKSCRECR 357
SC + NC PD + + G CRPK C G A G I C
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINEC---- 312
Query: 358 GGVLVKITEMCP-PLNCSEKDHILPENQCCRVC-RGHNFCAEGPKCGENSECK------- 408
+ I+ CP C + + C RG++ EG +C + EC
Sbjct: 313 ----LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
Query: 409 ------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
N CECK+GY G S C D++EC + C N G Y C C
Sbjct: 369 KGHRCVNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSC 426
Query: 463 VPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE 521
G+ + VD SC + +EC S C + C N + C C+ GY +
Sbjct: 427 SVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDV-------- 474
Query: 522 GCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
G TC ++C P TG H CS RC+N+PG + C C S
Sbjct: 475 ---DGVTCEDIDECALP---TGGHI------CS---------YRCINIPGSFQCSCPSSG 513
Query: 582 HDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL---CPSGPSCSGDCPHEG 638
+ + +G +C DIDEC H C + C N+ GGF CL CP S
Sbjct: 514 Y---RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSK 570
Query: 639 GLKHNGQVWTLKEDRCSVCSCKDG 662
+ N + KED C V K G
Sbjct: 571 KGRQNTPAGSSKED-CRVLPWKQG 593
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 133 bits (334), Expect = 8e-31
Identities = 110/408 (26%), Positives = 159/408 (38%), Gaps = 101/408 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCT----CKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCID 596
D+DEC+ C RCVN PG + CEC++G++ DG C+D
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI----SRMCVD 399
Query: 597 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
++EC R C N G + C C G S D + E S
Sbjct: 400 VNECQ-RYPGRLCGHKCENTLGSYLCSCSVGFRLSVD---------GRSCEDINECSSSP 449
Query: 657 CSCKDGKI------FCRR---------TAC----DCQNPSADLFCCPEC-DTRVTSQC-L 695
CS + + +CRR C +C P+ C C + + QC
Sbjct: 450 CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509
Query: 696 DQNGHKLYRSGDN---------WTHSC---QQCRCLEGEVDCWPLTCP 731
+G++L +G N H+C + C ++G C CP
Sbjct: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 104 bits (259), Expect = 4e-22
Identities = 112/407 (27%), Positives = 153/407 (37%), Gaps = 96/407 (23%)
Query: 267 CHCEKTCQV--SGLLYRDQDSWVDGDH-CR---NCTCKSGAVECRR-------------M 307
C C Q+ G+ D + + G H CR +C G+ C+R
Sbjct: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN 258
Query: 308 SCPPL--------NCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQRILTKSCRECR 357
SC + NC PD + + G CRPK C G A G I C
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINEC---- 312
Query: 358 GGVLVKITEMCP-PLNCSEKDHILPENQCCRVC-RGHNFCAEGPKCGENSECK------- 408
+ I+ CP C + + C RG++ EG +C + EC
Sbjct: 313 ----LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
Query: 409 ------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
N CECK+GY G S C D++EC + C N G Y C C
Sbjct: 369 KGHRCVNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSC 426
Query: 463 VPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE 521
G+ + VD SC + +EC S C + C N + C C+ GY +
Sbjct: 427 SVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDV-------- 474
Query: 522 GCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
G TC ++C P TG H CS RC+N+PG + C C S
Sbjct: 475 ---DGVTCEDIDECALP---TGGHI------CS---------YRCINIPGSFQCSCPSSG 513
Query: 582 HDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL---CP 625
+ + +G +C DIDEC H C + C N+ GGF CL CP
Sbjct: 514 Y---RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 133 bits (334), Expect = 8e-31
Identities = 110/408 (26%), Positives = 159/408 (38%), Gaps = 101/408 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCT----CKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCID 596
D+DEC+ C RCVN PG + CEC++G++ DG C+D
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGI----SRMCVD 399
Query: 597 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
++EC R C N G + C C G S D + E S
Sbjct: 400 VNECQ-RYPGRLCGHKCENTLGSYLCSCSVGFRLSVD---------GRSCEDINECSSSP 449
Query: 657 CSCKDGKI------FCRR---------TAC----DCQNPSADLFCCPEC-DTRVTSQC-L 695
CS + + +CRR C +C P+ C C + + QC
Sbjct: 450 CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSC 509
Query: 696 DQNGHKLYRSGDN---------WTHSC---QQCRCLEGEVDCWPLTCP 731
+G++L +G N H+C + C ++G C CP
Sbjct: 510 PSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 104 bits (259), Expect = 4e-22
Identities = 112/407 (27%), Positives = 153/407 (37%), Gaps = 96/407 (23%)
Query: 267 CHCEKTCQV--SGLLYRDQDSWVDGDH-CR---NCTCKSGAVECRR-------------M 307
C C Q+ G+ D + + G H CR +C G+ C+R
Sbjct: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN 258
Query: 308 SCPPL--------NCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQRILTKSCRECR 357
SC + NC PD + + G CRPK C G A G I C
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINEC---- 312
Query: 358 GGVLVKITEMCP-PLNCSEKDHILPENQCCRVC-RGHNFCAEGPKCGENSECK------- 408
+ I+ CP C + + C RG++ EG +C + EC
Sbjct: 313 ----LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
Query: 409 ------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
N CECK+GY G S C D++EC + C N G Y C C
Sbjct: 369 KGHRCVNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSC 426
Query: 463 VPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE 521
G+ + VD SC + +EC S C + C N + C C+ GY +
Sbjct: 427 SVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDV-------- 474
Query: 522 GCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
G TC ++C P TG H CS RC+N+PG + C C S
Sbjct: 475 ---DGVTCEDIDECALP---TGGHI------CS---------YRCINIPGSFQCSCPSSG 513
Query: 582 HDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL---CP 625
+ + +G +C DIDEC H C + C N+ GGF CL CP
Sbjct: 514 Y---RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 131 bits (330), Expect = 2e-30
Identities = 156/590 (26%), Positives = 207/590 (35%), Gaps = 112/590 (18%)
Query: 284 DSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC--RPKCIYGGKV 341
D W+ G C+ CK G P C G+ C C P C++G V
Sbjct: 233 DGWM-GKECKEAVCKQGCNLLHGGCTVPGECR---CSYGWQGRFCDECVPYPGCVHGSCV 288
Query: 342 LAEGQRILTKSCRECRGGVLV-KITEMC----PPLNCSEKDHILPENQCC--------RV 388
+C GG+L K C P N + P+ C R
Sbjct: 289 -----EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343
Query: 389 C-RGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C + + C P C C + C C SG+ DIDECA+ C A
Sbjct: 344 CEKAEHACTSNP-CANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNP--CAA 396
Query: 448 NTVCVNLPGLYRCDCVPGYIRVDDFSCT-EHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
CV+ + C C ++ +C + +EC C C N + G+ C C P
Sbjct: 397 GGTCVDQVDGFECICPEQWVGA---TCQLDANECEGKP--CLNAFSCKNLIGGYYCDCIP 451
Query: 507 GYVG-NGTICRAFCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECSEGIIECHN 562
G+ G N I C C++GGTC V +CVCP GF G HCE + DEC+ CH+
Sbjct: 452 GWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS--PCHS 509
Query: 563 HSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLAGGFD 621
C +L +HC C GF SG C +D+D C C N + C NL G +
Sbjct: 510 GGLCEDLADGFHCHCPQGF--------SGPLCEVDVDLC--EPSPCRNGARCYNLEGDYY 559
Query: 622 CLCP---SGPSCS--------GDCPHEGGLKHN---GQVWTLKEDRCSV---CSCKDGKI 664
C CP G +CS G C G + G T C C + G
Sbjct: 560 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 619
Query: 665 FCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCL----- 719
F +C C + +C D + C R+G RC
Sbjct: 620 F----SCICDSGFTGTYCHENIDDCLGQPC---------RNGGTCIDEVDAFRCFCPSGW 666
Query: 720 EGEV------DCWPLTCPNLSCEYTAILEGECC-------PRCVSDPCLADNITYDIRKT 766
EGE+ DC P C + Y + + C C S D T T
Sbjct: 667 EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGT 726
Query: 767 CLDSYGVSRLS------GSVWTMA-GSPCTTCKCKNGRVC--CSVDFECL 807
C DS R + GS +A S C C NG C F C+
Sbjct: 727 CYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 776
Score = 108 bits (269), Expect = 3e-23
Identities = 157/641 (24%), Positives = 221/641 (34%), Gaps = 179/641 (27%)
Query: 212 MPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEK 271
+P+G+ CP+ + PTC+ +D+ E + C
Sbjct: 365 VPSGFECHCPS-GWSGPTCA---------LDIDECASNP----------------CAAGG 398
Query: 272 TC--QVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCK 329
TC QV G + WV TC+ A EC C LN S I G C
Sbjct: 399 TCVDQVDGFECICPEQWV------GATCQLDANECEGKPC--LNAF--SCKNLIGGYYCD 448
Query: 330 VCRPKCIYGGKVLAEGQRILTKSCR-ECRGGVLVKITEMCPPLNCSEKDHILPENQCCRV 388
CI G K + I CR +C+ G K ++ C + P R
Sbjct: 449 -----CIPGWKGI--NCHINVNDCRGQCQHGGTCK--DLVNGYQC-----VCPRGFGGRH 494
Query: 389 CR-GHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCH 446
C + CA P C C++ C C G+ CE D+D C C
Sbjct: 495 CELERDECASSP-CHSGGLCEDLADGFHCHCPQGF-----SGPLCEVDVDLCEPSP--CR 546
Query: 447 ANTVCVNLPGLYRCDCVPGYIRVDDF---------------SCTEHDECGS--------- 482
C NL G Y C C DDF +C D CGS
Sbjct: 547 NGARCYNLEGDYYCACP------DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 600
Query: 483 -GQHNCDENAICTNTVQGH-SCTCKPGYVGNGTICRAFCEE----GCRYGGTC---VAPN 533
C + C + G+ SC C G+ G T C ++ CR GGTC V
Sbjct: 601 AASGVCGPHGRCVSQPGGNFSCICDSGFTG--TYCHENIDDCLGQPCRNGGTCIDEVDAF 658
Query: 534 KCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG----------FHD 583
+C CPSG+ G C+ + ++C CH+ RC +L ++C C G F
Sbjct: 659 RCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
Query: 584 DGTYSLSGESCIDIDE--------------CALRTHT------CWNDSACINLAGGFDCL 623
D +G +C D + CA+ ++ C N C+ F C+
Sbjct: 717 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 776
Query: 624 CPSG---PSCS---GDCP----HEGGLKHNGQVWTLKEDRCSVCSCKDGKIF--CRRTAC 671
C G +C+ DC + GG+ +G W C C G CR
Sbjct: 777 CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR-------CECAPGFAGPDCRINID 829
Query: 672 DCQN-PSADLFCCPE------CDT---RVTSQCLDQNGHKL--------YRSGDNWTHSC 713
+CQ+ P A C + C R +C + G + G +W C
Sbjct: 830 ECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDC 889
Query: 714 QQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPC 754
CRCL+G DC + C C +L G+ P +S C
Sbjct: 890 NSCRCLDGRRDCSKVWCGWKPC----LLAGQ--PEALSAQC 924
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 131 bits (329), Expect = 3e-30
Identities = 166/596 (27%), Positives = 233/596 (39%), Gaps = 95/596 (15%)
Query: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPD-SLPVHIAGQCCKVC 331
C L+ Q D + C CK R+ C P +L A Q C+
Sbjct: 872 CSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDI 931
Query: 332 RPKCIYGGKVLAEGQRILTKSCR--ECRGGVLVKITEMCPPLNCSEKDHILPENQC---- 385
+C G V + GQ T+ EC G ++ C +N P+ +C
Sbjct: 932 N-ECEQPG-VCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSP 989
Query: 386 ----CRVC----RGHN-FCAEGPKC-----GENSECKNWNTKATCECKSGYISVQGDSAY 431
C C RG + C + +C + +C N C C+ GY V D
Sbjct: 990 GSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGY-EVTSDEKG 1048
Query: 432 CEDIDECAAKMHYCHANTVCVNLPGLYRCD-CVPGY-IRVDDFSCTEHDECGSGQHNCDE 489
C+D+DECA++ C +C+N G + C C GY + D +C + DEC
Sbjct: 1049 CQDVDECASRAS-CPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP--GVCP 1104
Query: 490 NAICTNTVQGHSCT-CKPGYVGN--GTICRAF--CEE---GCRYGGTC---VAPNKCVCP 538
+ +CTNT SC C GY + G C CE+ C GG C V +C+CP
Sbjct: 1105 SGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCP 1163
Query: 539 SGF---TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
GF G+ CE D++EC G C H C+N G + C C GF + G SC
Sbjct: 1164 QGFQLANGTVCE-DVNECM-GEEHCAPHGECLNSHGSFFCLCAPGF----VSAEGGTSCQ 1217
Query: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSC-SGDCPHEGGLKHNGQ----VWT 648
D+DECA T C C+N G F+CLC +G PS SG+C + G W
Sbjct: 1218 DVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK 1275
Query: 649 LKED----RCSVCSCKDGKIFCRRTAC-DCQNPSADLFCCPE--CD-TRVTSQCLDQNGH 700
+ RC V C+ G C D + D C CD T + +CL G
Sbjct: 1276 CENSPGSYRC-VLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGF 1334
Query: 701 KLYRSGDNW----THSCQ---------QCRCLEGEVDCWPLTCPNLSCEYTAILEGECCP 747
++ SG W + C+ C +EG C C + EY A EG C P
Sbjct: 1335 EISPSG--WDCVDVNECELMLAVCGAALCENVEGSFLC---LCASDLEEYDA-QEGHCRP 1388
Query: 748 RCVSDPCLADNITYD--IRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCS 801
R +++ T D T +D Y + ++ G T +C CC+
Sbjct: 1389 RGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC-----CCT 1439
Score = 102 bits (255), Expect = 1e-21
Identities = 116/455 (25%), Positives = 169/455 (37%), Gaps = 88/455 (19%)
Query: 202 GIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQG-IMDLQELLAKMTAKLNYAETR 260
G DG+ + P Y TC C + G +D+ E L T
Sbjct: 978 GTCPDGRCVNSPGSY---------TCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC-TN 1027
Query: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRN-CTCKSGAVECRRMSCPPLNCSPDSL 319
L C CE+ +V+ D+ D D C + +C +G S C +
Sbjct: 1028 LEGSFRCSCEQGYEVTS----DEKGCQDVDECASRASCPTGLCLNTEGSFACSACE-NGY 1082
Query: 320 PVHIAGQCCKVCRPKCIYGGKVLAEGQRILTK---SCRECRGGVLVK-ITEMC------- 368
V+ G C+ +C + G V G T SC++C GG + + C
Sbjct: 1083 WVNEDGTACEDL-DECAFPG-VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE 1140
Query: 369 -PPLNC--SEKDHILPENQCC----------RVCRGHNFCAEGPKCGENSECKNWNTKAT 415
P +C E + + QC VC N C C + EC N +
Sbjct: 1141 DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSC 474
C C G++S +G ++ C+D+DECA + CVN G + C C G+ + C
Sbjct: 1201 CLCAPGFVSAEGGTS-CQDVDECATTDPCVGGH--CVNTEGSFNCLCETGFQPSPESGEC 1257
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCT--CKPGYVGNGTICRAFCEEGCRYGGTCVAP 532
+ DEC C N+ + C C+PG+ +AP
Sbjct: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF--------------------HMAP 1297
Query: 533 N-KCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSG 591
N C+ DIDEC+ + C +H C N G + C C GF S SG
Sbjct: 1298 NGDCI------------DIDECANDTM-CGSHGFCDNTDGSFRCLCDQGFE----ISPSG 1340
Query: 592 ESCIDIDECALRTHTCWNDSACINLAGGFDCLCPS 626
C+D++EC L C + C N+ G F CLC S
Sbjct: 1341 WDCVDVNECELMLAVC-GAALCENVEGSFLCLCAS 1374
Score = 100 bits (249), Expect = 5e-21
Identities = 122/422 (28%), Positives = 159/422 (37%), Gaps = 72/422 (17%)
Query: 435 IDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAIC 493
ID CAA CVNLP YRC C PGY + CT+ +EC + C C
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRC 902
Query: 494 TNTVQGHSCTCKPGYV----GNGTICRAF--CEE-GCRYGGTCV---APNKCVCPSGF-- 541
N V +SC C PGY G C+ CE+ G GG C C C G+
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
Query: 542 -TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHC-ECRSGFHDDGTYSLSGESCIDIDE 599
HC+ DI+EC C + RCVN PG Y C C G+ SG SC+D++E
Sbjct: 963 VRKGHCQ-DINECRHP-GTCPD-GRCVNSPGSYTCLACEEGYRGQ-----SG-SCVDVNE 1013
Query: 600 CALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC 659
C L C + C NL G F C C G + D E G + + + +C
Sbjct: 1014 C-LTPGVCAH-GKCTNLEGSFRCSCEQGYEVTSD---EKGCQDVDECASRASCPTGLCLN 1068
Query: 660 KDGKIFCRR-----------TACDCQNPSADLFCCPE---CDTRVTSQCLD-QNGHKLYR 704
+G C TAC+ + A CP +T + C D G++
Sbjct: 1069 TEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSP 1128
Query: 705 SGDNW--THSCQ--QCRCLEGE----VDCWPLTCP-------NLSCEYTAILEGE--CCP 747
GD+ C+ Q CL GE V + CP CE GE C P
Sbjct: 1129 LGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAP 1188
Query: 748 RCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVD--FE 805
CL + ++ CL + G G C T G C + + F
Sbjct: 1189 H---GECLNSHGSF----FCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFN 1241
Query: 806 CL 807
CL
Sbjct: 1242 CL 1243
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/198 (26%), Positives = 67/198 (33%), Gaps = 62/198 (31%)
Query: 460 CDCVPGYIRVD------DFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGT 513
C GYI V+ T+ DEC N C NTV G+ C C PG+
Sbjct: 1463 CPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGF----- 1517
Query: 514 ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSH--CEKDIDECSEGIIECHNHSRCVNLPG 571
+ SH CE D DEC + + C N CVN G
Sbjct: 1518 --------------------------HYDASHKKCE-DHDECQD--LACEN-GECVNTEG 1547
Query: 572 WYHCECRSGFHDDGTYSLSGESCI-------DIDECALRTHTCW----NDSACINLAGG- 619
+HC C T LS + C+ D+ + + CW ND L G
Sbjct: 1548 SFHCFCSPPL----TLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHR 1603
Query: 620 ---FDCLCPSGPSCSGDC 634
+C C G + S C
Sbjct: 1604 TTYTECCCQDGEAWSQQC 1621
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/106 (30%), Positives = 43/106 (40%), Gaps = 22/106 (20%)
Query: 538 PSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDI 597
P+GF G E EC GI+ + RCV + Y C+C GF D + +C+D+
Sbjct: 1726 PAGFEGLQAE----EC--GILNGCENGRCVRVREGYTCDCFEGFQLDAAHM----ACVDV 1775
Query: 598 DEC-------ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
+EC L H C N G + C C G PH
Sbjct: 1776 NECDDLNGPAVLCVH-----GYCENTEGSYRCHCSPGYVAEAGPPH 1816
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/52 (40%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 504 CKPGYV-GNGT--ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
C PG+ N T + CE C+ G+C P CVC SGF G+ CE+ I +
Sbjct: 173 CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPD 224
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 14/81 (17%)
Query: 397 EGPKCG-----ENSECKNWNTKATCECKSGYISVQGDSAY--CEDIDECA---AKMHYCH 446
+ +CG EN C TC+C G+ Q D+A+ C D++EC C
Sbjct: 1733 QAEECGILNGCENGRCVRVREGYTCDCFEGF---QLDAAHMACVDVNECDDLNGPAVLC- 1788
Query: 447 ANTVCVNLPGLYRCDCVPGYI 467
+ C N G YRC C PGY+
Sbjct: 1789 VHGYCENTEGSYRCHCSPGYV 1809
Score = 39.3 bits (90), Expect = 0.015
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 3/65 (4%)
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECG--SGQHNCDENAICTNTVQGHSCTC 504
N CV + Y CDC G+ + +C + +EC +G + C NT + C C
Sbjct: 1745 NGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHC 1804
Query: 505 KPGYV 509
PGYV
Sbjct: 1805 SPGYV 1809
Score = 38.5 bits (88), Expect = 0.025
Identities = 37/144 (25%), Positives = 56/144 (38%), Gaps = 23/144 (15%)
Query: 417 ECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTE 476
EC GY + + +C+DI+EC + C + CVN G Y C C PG + +D
Sbjct: 607 ECPQGYKRL--NLTHCQDINECLT-LGLCK-DAECVNTRGSYLCTCRPG-LMLD----PS 657
Query: 477 HDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC- 535
C S + +C ++ +CT IC G +G C KC
Sbjct: 658 RSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQIC-CCSRVGKAWGSEC---EKCP 713
Query: 536 ---------VCPSGFTGSHCEKDI 550
+CP+G ++ DI
Sbjct: 714 LPGTEAFREICPAGHGYTYASSDI 737
Score = 37.4 bits (85), Expect = 0.056
Identities = 34/126 (26%), Positives = 43/126 (34%), Gaps = 20/126 (15%)
Query: 398 GPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGL 457
GP N C N C C G+ CED DEC N CVN G
Sbjct: 1493 GPGLCPNGRCLNTVPGYVCLCNPGF-HYDASHKKCEDHDEC---QDLACENGECVNTEGS 1548
Query: 458 YRCDCVPGYIR-------VDDFSCTE----HDECGSGQHNCDENAICTNTVQGH-----S 501
+ C C P ++ S TE HD N +C+ ++GH
Sbjct: 1549 FHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTE 1608
Query: 502 CTCKPG 507
C C+ G
Sbjct: 1609 CCCQDG 1614
Score = 36.2 bits (82), Expect = 0.13
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
FC+ C GG C+ ++C CP+ TG C I +
Sbjct: 399 FCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQ 433
Score = 32.3 bits (72), Expect = 1.8
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 6/55 (10%)
Query: 537 CPSGFTG---SHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYS 588
CP G+ +HC+ DI+EC + + CVN G Y C CR G D + S
Sbjct: 608 CPQGYKRLNLTHCQ-DINECLT--LGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659
Score = 31.2 bits (69), Expect = 4.0
Identities = 26/110 (23%), Positives = 38/110 (34%), Gaps = 30/110 (27%)
Query: 472 FSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVA 531
F + +ECG N EN C +G++C C G+ + CV
Sbjct: 1729 FEGLQAEECGI--LNGCENGRCVRVREGYTCDCFEGFQLDAAHM------------ACVD 1774
Query: 532 PNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF 581
N+C D+ + + C H C N G Y C C G+
Sbjct: 1775 VNEC---------------DDLNGPAVLC-VHGYCENTEGSYRCHCSPGY 1808
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 130 bits (328), Expect = 4e-30
Identities = 82/229 (35%), Positives = 103/229 (44%), Gaps = 45/229 (19%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH 477
C+ GY +S C D+DECA H C+ +C+N G Y C C GY ++ C +
Sbjct: 113 CRFGY--QMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG-QCLDI 169
Query: 478 DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEG--CRYGGTCVAPNKC 535
DEC G C + +C N +SCTC PG+ N E+G C+ C N C
Sbjct: 170 DECRYGY--CQQ--LCANVPGSYSCTCNPGFTLN--------EDGRSCQDVNECATENPC 217
Query: 536 V-------------CPSGF----TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECR 578
V C G+ G HC D+DECS C + CVN PG Y C C
Sbjct: 218 VQTCVNTYGSFICRCDPGYELEEDGVHC-SDMDECSFSEFLCQH--ECVNQPGTYFCSCP 274
Query: 579 SGF--HDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP 625
G+ DD SC DI+EC R HTC C NL GGF C+ P
Sbjct: 275 PGYILLDD------NRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDP 317
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/348 (24%), Positives = 127/348 (36%), Gaps = 77/348 (22%)
Query: 450 VCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
+C+ PG + C G+ + C + DEC + C + +C N G+ C +
Sbjct: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
Query: 509 VGNGTICRAFCEEGCRYGG-------TCVAPN------KCVCPSGFTGSHCEK--DIDEC 553
V G + Y G APN +C G+ + D+DEC
Sbjct: 75 VYRGPYSNPY---STPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDEC 131
Query: 554 SEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSAC 613
+ +C+ C+N G Y C C DG + L G+ C+DIDEC R C C
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSC-----TDGYWLLEGQ-CLDIDEC--RYGYC--QQLC 181
Query: 614 INLAGGFDCLC-------PSGPSCS--GDCPHEGGLKHN------------GQVWTLKED 652
N+ G + C C G SC +C E + L+ED
Sbjct: 182 ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEED 241
Query: 653 --RCS-VCSCKDGKIFCRRTACDCQNPSADLFC-CPE----CDTRVTSQCLDQNGHKLYR 704
CS + C + C+ +C N FC CP D + Q +++ H+
Sbjct: 242 GVHCSDMDECSFSEFLCQH---ECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR--- 295
Query: 705 SGDNWTHSC---QQCRCLEGEVDCW-PLTCPNLSCEYTAILEGEC-CP 747
H+C Q C L+G C P+ C Y I + C CP
Sbjct: 296 -----NHTCNLQQTCYNLQGGFKCIDPIRCEE---PYLRISDNRCMCP 335
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 130 bits (328), Expect = 4e-30
Identities = 113/359 (31%), Positives = 147/359 (40%), Gaps = 43/359 (11%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGY-ISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C P+ C + + TC C SG+ +S QG C D+DEC C A C N
Sbjct: 482 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR--CIDVDECRRVPPPC-APGRCEN 538
Query: 454 LPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-- 510
PG +RC C PG+ + C + DEC CD C NT C C GY
Sbjct: 539 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAP 597
Query: 511 NGTICRAF--CEEG---CRYGGTCVAPN--KCVCPSGFTGSHCEKDIDECSEGIIECHNH 563
+G C+ C + C G P +CVCP+GF GS CE+D+DEC++ C
Sbjct: 598 HGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GP 656
Query: 564 SRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL 623
RC N G +HC C +GF G G C D+DECA C C N G F C+
Sbjct: 657 GRCDNTAGSFHCACPAGFRSRG----PGAPCQDVDECARSPPPC-TYGRCENTEGSFQCV 711
Query: 624 CPSG--PSCSG-DCPH----EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNP 676
CP G P+ +G +C E L GQ +C G R D
Sbjct: 712 CPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDEC 771
Query: 677 SADLFCCPEC-------DTRVTSQCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWP 727
S+ P C +T + +C G YR+ C CLEG+ C+P
Sbjct: 772 SSG---APPCGPHGHCTNTEGSFRCSCAPG---YRAPSGRPGPCADVNECLEGDF-CFP 823
Score = 127 bits (318), Expect = 5e-29
Identities = 90/297 (30%), Positives = 120/297 (40%), Gaps = 40/297 (13%)
Query: 368 CPPLNCSEKDHILPENQCCRVC-RGHNF----------CAEG-PKCGENSECKNWNTKAT 415
CP C P + CR C GH+ C+ G P CG + C N
Sbjct: 737 CPGQECVNS----PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR 792
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVD-DFSC 474
C C GY + G C D++EC + +C + C+N G + C C PGY SC
Sbjct: 793 CSCAPGYRAPSGRPGPCADVNECL-EGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 851
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPN- 533
+ DEC + + ++ ICTNT C C PG+ + + CR G + +
Sbjct: 852 LDVDECS--EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 909
Query: 534 ---------KCV--CPSGFTGSH---CEKDIDECSEGIIECHNHSRCVNLPGWYHCECRS 579
+CV C G+ C+ D+DEC E E RC N PG Y C
Sbjct: 910 RCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPAC 968
Query: 580 GFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
D G G C D+DEC R+ C + C NL G F CLC G + D H
Sbjct: 969 ---DPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1021
Score = 118 bits (296), Expect = 2e-26
Identities = 87/299 (29%), Positives = 112/299 (37%), Gaps = 56/299 (18%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + CA P C+N C C G+ S CED+DEC + H
Sbjct: 683 CQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE-CEDVDEC--ENHLACPG 739
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
CVN PG ++C P + CT+ DEC SG C + CTNT C+C PGY
Sbjct: 740 QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY 799
Query: 509 VGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVN 568
RA PSG G C D++EC EG C H C+N
Sbjct: 800 -------RA--------------------PSGRPGP-C-ADVNECLEGDF-CFPHGECLN 829
Query: 569 LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 628
G + C C G+ G SC+D+DEC+ C N G F+C+CP G
Sbjct: 830 TDGSFACTCAPGYRP----GPRGASCLDVDECS--EEDLCQSGICTNTDGSFECICPPGH 883
Query: 629 SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECD 687
D L D C + G C C+N C +CD
Sbjct: 884 RAGPDLAS-----------CLDVDECR----ERGPALCGSQR--CENSPGSYRCVRDCD 925
Score = 108 bits (269), Expect = 3e-23
Identities = 110/397 (27%), Positives = 146/397 (36%), Gaps = 66/397 (16%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + C + P CKN C C +G+ SA ED+DECA + C
Sbjct: 602 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPG 657
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
C N G + C C G+ R C + DEC C C NT C C G
Sbjct: 658 R-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMG 715
Query: 508 YVGN--GTICRAF--CEE--GCRYGGTCV-APNKCVCPSGFTGSHCEK----DIDECSEG 556
+ N G+ C CE C G CV +P C + +G H + D+DECS G
Sbjct: 716 FQPNTAGSECEDVDECENHLACP-GQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG 774
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGE--SCIDIDECALRTHTCWNDSACI 614
C H C N G + C C G+ + SG C D++EC L C+ C+
Sbjct: 775 APPCGPHGHCTNTEGSFRCSCAPGYR-----APSGRPGPCADVNEC-LEGDFCFPHGECL 828
Query: 615 NLAGGFDCLC-------PSGPSC--SGDCPHEGGLKHNGQVWTLKEDRC--SVCSCKDGK 663
N G F C C P G SC +C +ED C +C+ DG
Sbjct: 829 NTDGSFACTCAPGYRPGPRGASCLDVDECS--------------EEDLCQSGICTNTDGS 874
Query: 664 IFCRRTACDCQNPSADLFCC---PECDTRVTSQCLDQ------NGHKLYRSGDNWTHSCQ 714
C P DL C EC R + C Q ++ R D H+
Sbjct: 875 FECICPPGHRAGP--DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP 932
Query: 715 QCRC--LEGEVDCWPLTCPNLSCEYTAILEGECCPRC 749
+ C ++ + P C CE T C P C
Sbjct: 933 EGTCDDVDECQEYGPEICGAQRCENTP-GSYRCTPAC 968
Score = 75.5 bits (184), Expect = 2e-13
Identities = 125/514 (24%), Positives = 174/514 (33%), Gaps = 111/514 (21%)
Query: 282 DQDSWVDGDHCRN--CTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGG 339
D D + D C++ CT G+ EC CPP + + L C V +C G
Sbjct: 853 DVDECSEEDLCQSGICTNTDGSFEC---ICPPGHRAGPDL-----ASCLDV--DECRERG 902
Query: 340 KVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAE-G 398
L QR C G +C H PE C V + C E G
Sbjct: 903 PALCGSQR-----CENSPGSYRCV-------RDCDPGYHAGPEGTCDDV----DECQEYG 946
Query: 399 PKCGENSECKNW--NTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPG 456
P+ C+N + + T C GY G C+D+DEC + +C A+ VC NLPG
Sbjct: 947 PEICGAQRCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRS-FCGAHAVCQNLPG 1003
Query: 457 LYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG----N 511
++C C GY D C + +EC + Q C A+C N C C
Sbjct: 1004 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEFDPMT 1062
Query: 512 GTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGII-----ECHNHS-- 564
G G G AP V P+ + +G + EC+ +
Sbjct: 1063 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAA 1122
Query: 565 --RCVNLPG----WYHCECRSGF------------------------HDDGTYSLSGESC 594
C N+ W C C G H G + SG+
Sbjct: 1123 PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1182
Query: 595 I--DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKED 652
+ D+DEC L C+N A G+ C C + G H ++ + D
Sbjct: 1183 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN-----------GYYYHTQRLECIDND 1231
Query: 653 RCS--VCSCKDGKIFCRRTA----CDCQNPSADLFCCPECDTRVTSQCLDQN-------- 698
C+ +C+ G+ C T C C+ P C + SQ LD N
Sbjct: 1232 ECADEEPACEGGR--CVNTVGSYHCTCEPPLVLDGSQRRCVSN-ESQSLDDNLGVCWQEV 1288
Query: 699 GHKLYRSGDNWTHSC--QQCRCLEGEVDCWPLTC 730
G L S +C CL GE W + C
Sbjct: 1289 GADLVCSHPRLDRQATYTECCCLYGE--AWGMDC 1320
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 22/110 (20%)
Query: 521 EGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
EG Y G+ P + E + +EC GI++ + RCV +P + C C G
Sbjct: 1450 EGGSYAGSLAEPYE------------ELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDG 1495
Query: 581 FHDDGTYSLSGESCIDIDEC---ALRTHTCWNDSACINLAGGFDCLCPSG 627
+ D ++ +C+DI+EC + C N + C+N G F C+C G
Sbjct: 1496 YRLD----MTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCICRPG 1540
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/173 (27%), Positives = 70/173 (40%), Gaps = 29/173 (16%)
Query: 515 CRAFCEEGCRYGGTCV--APN-KCVCPSGFTGSHCEK----DIDECSEGIIECHNHSRCV 567
C+ F ++ C+ G CV AP C C +G+ H ++ D DEC++ C RCV
Sbjct: 1190 CQLFRDQVCK-SGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEG-GRCV 1246
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTH--TCWNDSACINLAGGFDCLCP 625
N G YHC C DG S C+ + +L + CW + G D +C
Sbjct: 1247 NTVGSYHCTCEPPLVLDG----SQRRCVSNESQSLDDNLGVCWQEV-------GADLVC- 1294
Query: 626 SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSA 678
S P + G+ W + C++C +D F C+ P A
Sbjct: 1295 SHPRLDRQATYTECCCLYGEAWGMD---CALCPAQDSDDF--EALCNVLRPPA 1342
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/70 (34%), Positives = 29/70 (41%), Gaps = 15/70 (21%)
Query: 493 CTNTVQGHSCT--CKP------------GYVGNGTICRAF-CEEGCRYGGTCVAPNKCVC 537
C + G CT C P G G RAF C C GG CV P++C+C
Sbjct: 45 CVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLC 104
Query: 538 PSGFTGSHCE 547
P F G C+
Sbjct: 105 PPDFAGKFCQ 114
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/61 (42%), Positives = 30/61 (49%), Gaps = 9/61 (14%)
Query: 537 CPSGF--TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC 594
CP+GF CE D+DEC+ G C H C N G Y C C GF D + S SC
Sbjct: 277 CPTGFERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGFLLDSSRS----SC 329
Query: 595 I 595
I
Sbjct: 330 I 330
Score = 39.3 bits (90), Expect = 0.015
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 20/107 (18%)
Query: 526 GGTCVAP-----NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
GG C +P + VC G + D CSE + +S V+ P C +G
Sbjct: 228 GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERL----GNSERVSAPDG---PCPTG 280
Query: 581 FHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
F ++G SC D+DECA T C N GG+ C+CP G
Sbjct: 281 FE-----RVNG-SCEDVDECA--TGGRCQHGECANTRGGYTCVCPDG 319
Score = 38.9 bits (89), Expect = 0.019
Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 10/78 (12%)
Query: 397 EGPKCG-----ENSECKNWNTKATCECKSGYISVQGDSAYCEDIDEC---AAKMHYCHAN 448
E +CG N C TC C GY + C DI+EC A C N
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPLC-VN 1523
Query: 449 TVCVNLPGLYRCDCVPGY 466
C+N G +RC C PG+
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541
Score = 38.9 bits (89), Expect = 0.019
Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCD--ENAICTNTVQGHSCTC 504
N CV +P + C C GY + + +C + +EC + NA C NT C C
Sbjct: 1478 NGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCIC 1537
Query: 505 KPGY 508
+PG+
Sbjct: 1538 RPGF 1541
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYI 467
C +G+ V G CED+DECA H C N G Y C C G++
Sbjct: 277 CPTGFERVNGS---CEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFL 321
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 462 CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
C G+ RV+ SC + DEC +G C ++ C NT G++C C G++
Sbjct: 277 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFL 321
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 521 EGCRYGGTCVAPN--KCVCPSGF----TGSHCEKDIDECSEGIIE---CHNHSRCVNLPG 571
+GC G P C C G+ T C DI+EC E C N +RC+N G
Sbjct: 1474 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVN-ARCLNTDG 1531
Query: 572 WYHCECRSGF 581
+ C CR GF
Sbjct: 1532 SFRCICRPGF 1541
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 130 bits (328), Expect = 4e-30
Identities = 113/359 (31%), Positives = 147/359 (40%), Gaps = 43/359 (11%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGY-ISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C P+ C + + TC C SG+ +S QG C D+DEC C A C N
Sbjct: 512 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR--CIDVDECRRVPPPC-APGRCEN 568
Query: 454 LPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-- 510
PG +RC C PG+ + C + DEC CD C NT C C GY
Sbjct: 569 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAP 627
Query: 511 NGTICRAF--CEEG---CRYGGTCVAPN--KCVCPSGFTGSHCEKDIDECSEGIIECHNH 563
+G C+ C + C G P +CVCP+GF GS CE+D+DEC++ C
Sbjct: 628 HGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GP 686
Query: 564 SRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL 623
RC N G +HC C +GF G G C D+DECA C C N G F C+
Sbjct: 687 GRCDNTAGSFHCACPAGFRSRG----PGAPCQDVDECARSPPPC-TYGRCENTEGSFQCV 741
Query: 624 CPSG--PSCSG-DCPH----EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNP 676
CP G P+ +G +C E L GQ +C G R D
Sbjct: 742 CPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDEC 801
Query: 677 SADLFCCPEC-------DTRVTSQCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWP 727
S+ P C +T + +C G YR+ C CLEG+ C+P
Sbjct: 802 SSG---APPCGPHGHCTNTEGSFRCSCAPG---YRAPSGRPGPCADVNECLEGDF-CFP 853
Score = 127 bits (318), Expect = 5e-29
Identities = 90/297 (30%), Positives = 120/297 (40%), Gaps = 40/297 (13%)
Query: 368 CPPLNCSEKDHILPENQCCRVC-RGHNF----------CAEG-PKCGENSECKNWNTKAT 415
CP C P + CR C GH+ C+ G P CG + C N
Sbjct: 767 CPGQECVNS----PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR 822
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVD-DFSC 474
C C GY + G C D++EC + +C + C+N G + C C PGY SC
Sbjct: 823 CSCAPGYRAPSGRPGPCADVNECL-EGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 881
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPN- 533
+ DEC + + ++ ICTNT C C PG+ + + CR G + +
Sbjct: 882 LDVDECS--EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 939
Query: 534 ---------KCV--CPSGFTGSH---CEKDIDECSEGIIECHNHSRCVNLPGWYHCECRS 579
+CV C G+ C+ D+DEC E E RC N PG Y C
Sbjct: 940 RCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPAC 998
Query: 580 GFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
D G G C D+DEC R+ C + C NL G F CLC G + D H
Sbjct: 999 ---DPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1051
Score = 118 bits (296), Expect = 2e-26
Identities = 87/299 (29%), Positives = 112/299 (37%), Gaps = 56/299 (18%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + CA P C+N C C G+ S CED+DEC + H
Sbjct: 713 CQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE-CEDVDEC--ENHLACPG 769
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
CVN PG ++C P + CT+ DEC SG C + CTNT C+C PGY
Sbjct: 770 QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY 829
Query: 509 VGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVN 568
RA PSG G C D++EC EG C H C+N
Sbjct: 830 -------RA--------------------PSGRPGP-C-ADVNECLEGDF-CFPHGECLN 859
Query: 569 LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 628
G + C C G+ G SC+D+DEC+ C N G F+C+CP G
Sbjct: 860 TDGSFACTCAPGYRP----GPRGASCLDVDECS--EEDLCQSGICTNTDGSFECICPPGH 913
Query: 629 SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECD 687
D L D C + G C C+N C +CD
Sbjct: 914 RAGPDLAS-----------CLDVDECR----ERGPALCGSQR--CENSPGSYRCVRDCD 955
Score = 108 bits (269), Expect = 3e-23
Identities = 110/397 (27%), Positives = 146/397 (36%), Gaps = 66/397 (16%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + C + P CKN C C +G+ SA ED+DECA + C
Sbjct: 632 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPG 687
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
C N G + C C G+ R C + DEC C C NT C C G
Sbjct: 688 R-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMG 745
Query: 508 YVGN--GTICRAF--CEE--GCRYGGTCV-APNKCVCPSGFTGSHCEK----DIDECSEG 556
+ N G+ C CE C G CV +P C + +G H + D+DECS G
Sbjct: 746 FQPNTAGSECEDVDECENHLACP-GQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG 804
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGE--SCIDIDECALRTHTCWNDSACI 614
C H C N G + C C G+ + SG C D++EC L C+ C+
Sbjct: 805 APPCGPHGHCTNTEGSFRCSCAPGYR-----APSGRPGPCADVNEC-LEGDFCFPHGECL 858
Query: 615 NLAGGFDCLC-------PSGPSC--SGDCPHEGGLKHNGQVWTLKEDRC--SVCSCKDGK 663
N G F C C P G SC +C +ED C +C+ DG
Sbjct: 859 NTDGSFACTCAPGYRPGPRGASCLDVDECS--------------EEDLCQSGICTNTDGS 904
Query: 664 IFCRRTACDCQNPSADLFCC---PECDTRVTSQCLDQ------NGHKLYRSGDNWTHSCQ 714
C P DL C EC R + C Q ++ R D H+
Sbjct: 905 FECICPPGHRAGP--DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP 962
Query: 715 QCRC--LEGEVDCWPLTCPNLSCEYTAILEGECCPRC 749
+ C ++ + P C CE T C P C
Sbjct: 963 EGTCDDVDECQEYGPEICGAQRCENTP-GSYRCTPAC 998
Score = 75.5 bits (184), Expect = 2e-13
Identities = 125/514 (24%), Positives = 174/514 (33%), Gaps = 111/514 (21%)
Query: 282 DQDSWVDGDHCRN--CTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGG 339
D D + D C++ CT G+ EC CPP + + L C V +C G
Sbjct: 883 DVDECSEEDLCQSGICTNTDGSFEC---ICPPGHRAGPDL-----ASCLDV--DECRERG 932
Query: 340 KVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAE-G 398
L QR C G +C H PE C V + C E G
Sbjct: 933 PALCGSQR-----CENSPGSYRCV-------RDCDPGYHAGPEGTCDDV----DECQEYG 976
Query: 399 PKCGENSECKNW--NTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPG 456
P+ C+N + + T C GY G C+D+DEC + +C A+ VC NLPG
Sbjct: 977 PEICGAQRCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRS-FCGAHAVCQNLPG 1033
Query: 457 LYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG----N 511
++C C GY D C + +EC + Q C A+C N C C
Sbjct: 1034 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEFDPMT 1092
Query: 512 GTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGII-----ECHNHS-- 564
G G G AP V P+ + +G + EC+ +
Sbjct: 1093 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAA 1152
Query: 565 --RCVNLPG----WYHCECRSGF------------------------HDDGTYSLSGESC 594
C N+ W C C G H G + SG+
Sbjct: 1153 PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1212
Query: 595 I--DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKED 652
+ D+DEC L C+N A G+ C C + G H ++ + D
Sbjct: 1213 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN-----------GYYYHTQRLECIDND 1261
Query: 653 RCS--VCSCKDGKIFCRRTA----CDCQNPSADLFCCPECDTRVTSQCLDQN-------- 698
C+ +C+ G+ C T C C+ P C + SQ LD N
Sbjct: 1262 ECADEEPACEGGR--CVNTVGSYHCTCEPPLVLDGSQRRCVSN-ESQSLDDNLGVCWQEV 1318
Query: 699 GHKLYRSGDNWTHSC--QQCRCLEGEVDCWPLTC 730
G L S +C CL GE W + C
Sbjct: 1319 GADLVCSHPRLDRQATYTECCCLYGE--AWGMDC 1350
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 22/110 (20%)
Query: 521 EGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
EG Y G+ P + E + +EC GI++ + RCV +P + C C G
Sbjct: 1480 EGGSYAGSLAEPYE------------ELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDG 1525
Query: 581 FHDDGTYSLSGESCIDIDEC---ALRTHTCWNDSACINLAGGFDCLCPSG 627
+ D ++ +C+DI+EC + C N + C+N G F C+C G
Sbjct: 1526 YRLD----MTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCICRPG 1570
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/173 (27%), Positives = 70/173 (40%), Gaps = 29/173 (16%)
Query: 515 CRAFCEEGCRYGGTCV--APN-KCVCPSGFTGSHCEK----DIDECSEGIIECHNHSRCV 567
C+ F ++ C+ G CV AP C C +G+ H ++ D DEC++ C RCV
Sbjct: 1220 CQLFRDQVCK-SGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEG-GRCV 1276
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTH--TCWNDSACINLAGGFDCLCP 625
N G YHC C DG S C+ + +L + CW + G D +C
Sbjct: 1277 NTVGSYHCTCEPPLVLDG----SQRRCVSNESQSLDDNLGVCWQEV-------GADLVC- 1324
Query: 626 SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSA 678
S P + G+ W + C++C +D F C+ P A
Sbjct: 1325 SHPRLDRQATYTECCCLYGEAWGMD---CALCPAQDSDDF--EALCNVLRPPA 1372
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/61 (42%), Positives = 30/61 (49%), Gaps = 9/61 (14%)
Query: 537 CPSGF--TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC 594
CP+GF CE D+DEC+ G C H C N G Y C C GF D + S SC
Sbjct: 307 CPTGFERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGFLLDSSRS----SC 359
Query: 595 I 595
I
Sbjct: 360 I 360
Score = 39.3 bits (90), Expect = 0.015
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 20/107 (18%)
Query: 526 GGTCVAP-----NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
GG C +P + VC G + D CSE + +S V+ P C +G
Sbjct: 258 GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERL----GNSERVSAPDG---PCPTG 310
Query: 581 FHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
F ++G SC D+DECA T C N GG+ C+CP G
Sbjct: 311 FE-----RVNG-SCEDVDECA--TGGRCQHGECANTRGGYTCVCPDG 349
Score = 38.9 bits (89), Expect = 0.019
Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 10/78 (12%)
Query: 397 EGPKCG-----ENSECKNWNTKATCECKSGYISVQGDSAYCEDIDEC---AAKMHYCHAN 448
E +CG N C TC C GY + C DI+EC A C N
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPLC-VN 1553
Query: 449 TVCVNLPGLYRCDCVPGY 466
C+N G +RC C PG+
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571
Score = 38.9 bits (89), Expect = 0.019
Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCD--ENAICTNTVQGHSCTC 504
N CV +P + C C GY + + +C + +EC + NA C NT C C
Sbjct: 1508 NGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCIC 1567
Query: 505 KPGY 508
+PG+
Sbjct: 1568 RPGF 1571
Score = 38.5 bits (88), Expect = 0.025
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 519 CEEGCRYGGTCVAPNKCVCPSGFTGSHCE 547
C C GG CV P++C+CP F G C+
Sbjct: 116 CPLICHNGGVCVKPDRCLCPPDFAGKFCQ 144
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYI 467
C +G+ V G CED+DECA H C N G Y C C G++
Sbjct: 307 CPTGFERVNGS---CEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFL 351
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 462 CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
C G+ RV+ SC + DEC +G C ++ C NT G++C C G++
Sbjct: 307 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFL 351
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 521 EGCRYGGTCVAPN--KCVCPSGF----TGSHCEKDIDECSEGIIE---CHNHSRCVNLPG 571
+GC G P C C G+ T C DI+EC E C N +RC+N G
Sbjct: 1504 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVN-ARCLNTDG 1561
Query: 572 WYHCECRSGF 581
+ C CR GF
Sbjct: 1562 SFRCICRPGF 1571
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 130 bits (328), Expect = 4e-30
Identities = 113/359 (31%), Positives = 147/359 (40%), Gaps = 43/359 (11%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGY-ISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C P+ C + + TC C SG+ +S QG C D+DEC C A C N
Sbjct: 549 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR--CIDVDECRRVPPPC-APGRCEN 605
Query: 454 LPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-- 510
PG +RC C PG+ + C + DEC CD C NT C C GY
Sbjct: 606 SPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAP 664
Query: 511 NGTICRAF--CEEG---CRYGGTCVAPN--KCVCPSGFTGSHCEKDIDECSEGIIECHNH 563
+G C+ C + C G P +CVCP+GF GS CE+D+DEC++ C
Sbjct: 665 HGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GP 723
Query: 564 SRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCL 623
RC N G +HC C +GF G G C D+DECA C C N G F C+
Sbjct: 724 GRCDNTAGSFHCACPAGFRSRG----PGAPCQDVDECARSPPPC-TYGRCENTEGSFQCV 778
Query: 624 CPSG--PSCSG-DCPH----EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNP 676
CP G P+ +G +C E L GQ +C G R D
Sbjct: 779 CPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDEC 838
Query: 677 SADLFCCPEC-------DTRVTSQCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWP 727
S+ P C +T + +C G YR+ C CLEG+ C+P
Sbjct: 839 SSG---APPCGPHGHCTNTEGSFRCSCAPG---YRAPSGRPGPCADVNECLEGDF-CFP 890
Score = 127 bits (318), Expect = 5e-29
Identities = 90/297 (30%), Positives = 120/297 (40%), Gaps = 40/297 (13%)
Query: 368 CPPLNCSEKDHILPENQCCRVC-RGHNF----------CAEG-PKCGENSECKNWNTKAT 415
CP C P + CR C GH+ C+ G P CG + C N
Sbjct: 804 CPGQECVNS----PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFR 859
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVD-DFSC 474
C C GY + G C D++EC + +C + C+N G + C C PGY SC
Sbjct: 860 CSCAPGYRAPSGRPGPCADVNECL-EGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC 918
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPN- 533
+ DEC + + ++ ICTNT C C PG+ + + CR G + +
Sbjct: 919 LDVDECS--EEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 976
Query: 534 ---------KCV--CPSGFTGSH---CEKDIDECSEGIIECHNHSRCVNLPGWYHCECRS 579
+CV C G+ C+ D+DEC E E RC N PG Y C
Sbjct: 977 RCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPAC 1035
Query: 580 GFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 636
D G G C D+DEC R+ C + C NL G F CLC G + D H
Sbjct: 1036 ---DPGYQPTPGGGCQDVDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1088
Score = 118 bits (296), Expect = 2e-26
Identities = 87/299 (29%), Positives = 112/299 (37%), Gaps = 56/299 (18%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + CA P C+N C C G+ S CED+DEC + H
Sbjct: 750 CQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE-CEDVDEC--ENHLACPG 806
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
CVN PG ++C P + CT+ DEC SG C + CTNT C+C PGY
Sbjct: 807 QECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY 866
Query: 509 VGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVN 568
RA PSG G C D++EC EG C H C+N
Sbjct: 867 -------RA--------------------PSGRPGP-C-ADVNECLEGDF-CFPHGECLN 896
Query: 569 LPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 628
G + C C G+ G SC+D+DEC+ C N G F+C+CP G
Sbjct: 897 TDGSFACTCAPGYRP----GPRGASCLDVDECS--EEDLCQSGICTNTDGSFECICPPGH 950
Query: 629 SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECD 687
D L D C + G C C+N C +CD
Sbjct: 951 RAGPDLAS-----------CLDVDECR----ERGPALCGSQR--CENSPGSYRCVRDCD 992
Score = 108 bits (269), Expect = 3e-23
Identities = 110/397 (27%), Positives = 146/397 (36%), Gaps = 66/397 (16%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C+ + C + P CKN C C +G+ SA ED+DECA + C
Sbjct: 669 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPG 724
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
C N G + C C G+ R C + DEC C C NT C C G
Sbjct: 725 R-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMG 782
Query: 508 YVGN--GTICRAF--CEE--GCRYGGTCV-APNKCVCPSGFTGSHCEK----DIDECSEG 556
+ N G+ C CE C G CV +P C + +G H + D+DECS G
Sbjct: 783 FQPNTAGSECEDVDECENHLACP-GQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG 841
Query: 557 IIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGE--SCIDIDECALRTHTCWNDSACI 614
C H C N G + C C G+ + SG C D++EC L C+ C+
Sbjct: 842 APPCGPHGHCTNTEGSFRCSCAPGYR-----APSGRPGPCADVNEC-LEGDFCFPHGECL 895
Query: 615 NLAGGFDCLC-------PSGPSC--SGDCPHEGGLKHNGQVWTLKEDRC--SVCSCKDGK 663
N G F C C P G SC +C +ED C +C+ DG
Sbjct: 896 NTDGSFACTCAPGYRPGPRGASCLDVDECS--------------EEDLCQSGICTNTDGS 941
Query: 664 IFCRRTACDCQNPSADLFCC---PECDTRVTSQCLDQ------NGHKLYRSGDNWTHSCQ 714
C P DL C EC R + C Q ++ R D H+
Sbjct: 942 FECICPPGHRAGP--DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGP 999
Query: 715 QCRC--LEGEVDCWPLTCPNLSCEYTAILEGECCPRC 749
+ C ++ + P C CE T C P C
Sbjct: 1000 EGTCDDVDECQEYGPEICGAQRCENTP-GSYRCTPAC 1035
Score = 75.5 bits (184), Expect = 2e-13
Identities = 125/514 (24%), Positives = 174/514 (33%), Gaps = 111/514 (21%)
Query: 282 DQDSWVDGDHCRN--CTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGG 339
D D + D C++ CT G+ EC CPP + + L C V +C G
Sbjct: 920 DVDECSEEDLCQSGICTNTDGSFEC---ICPPGHRAGPDL-----ASCLDV--DECRERG 969
Query: 340 KVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAE-G 398
L QR C G +C H PE C V + C E G
Sbjct: 970 PALCGSQR-----CENSPGSYRCV-------RDCDPGYHAGPEGTCDDV----DECQEYG 1013
Query: 399 PKCGENSECKNW--NTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPG 456
P+ C+N + + T C GY G C+D+DEC + +C A+ VC NLPG
Sbjct: 1014 PEICGAQRCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRS-FCGAHAVCQNLPG 1070
Query: 457 LYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG----N 511
++C C GY D C + +EC + Q C A+C N C C
Sbjct: 1071 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVCPNSPEEFDPMT 1129
Query: 512 GTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGII-----ECHNHS-- 564
G G G AP V P+ + +G + EC+ +
Sbjct: 1130 GRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAA 1189
Query: 565 --RCVNLPG----WYHCECRSGF------------------------HDDGTYSLSGESC 594
C N+ W C C G H G + SG+
Sbjct: 1190 PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1249
Query: 595 I--DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKED 652
+ D+DEC L C+N A G+ C C + G H ++ + D
Sbjct: 1250 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN-----------GYYYHTQRLECIDND 1298
Query: 653 RCS--VCSCKDGKIFCRRTA----CDCQNPSADLFCCPECDTRVTSQCLDQN-------- 698
C+ +C+ G+ C T C C+ P C + SQ LD N
Sbjct: 1299 ECADEEPACEGGR--CVNTVGSYHCTCEPPLVLDGSQRRCVSN-ESQSLDDNLGVCWQEV 1355
Query: 699 GHKLYRSGDNWTHSC--QQCRCLEGEVDCWPLTC 730
G L S +C CL GE W + C
Sbjct: 1356 GADLVCSHPRLDRQATYTECCCLYGE--AWGMDC 1387
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 22/110 (20%)
Query: 521 EGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
EG Y G+ P + E + +EC GI++ + RCV +P + C C G
Sbjct: 1517 EGGSYAGSLAEPYE------------ELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDG 1562
Query: 581 FHDDGTYSLSGESCIDIDEC---ALRTHTCWNDSACINLAGGFDCLCPSG 627
+ D ++ +C+DI+EC + C N + C+N G F C+C G
Sbjct: 1563 YRLD----MTRMACVDINECDEAEAASPLCVN-ARCLNTDGSFRCICRPG 1607
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/173 (27%), Positives = 70/173 (40%), Gaps = 29/173 (16%)
Query: 515 CRAFCEEGCRYGGTCV--APN-KCVCPSGFTGSHCEK----DIDECSEGIIECHNHSRCV 567
C+ F ++ C+ G CV AP C C +G+ H ++ D DEC++ C RCV
Sbjct: 1257 CQLFRDQVCK-SGVCVNTAPGYSCYCSNGYY-YHTQRLECIDNDECADEEPACEG-GRCV 1313
Query: 568 NLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTH--TCWNDSACINLAGGFDCLCP 625
N G YHC C DG S C+ + +L + CW + G D +C
Sbjct: 1314 NTVGSYHCTCEPPLVLDG----SQRRCVSNESQSLDDNLGVCWQEV-------GADLVC- 1361
Query: 626 SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSA 678
S P + G+ W + C++C +D F C+ P A
Sbjct: 1362 SHPRLDRQATYTECCCLYGEAWGMD---CALCPAQDSDDF--EALCNVLRPPA 1409
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/61 (42%), Positives = 30/61 (49%), Gaps = 9/61 (14%)
Query: 537 CPSGF--TGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC 594
CP+GF CE D+DEC+ G C H C N G Y C C GF D + S SC
Sbjct: 344 CPTGFERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGFLLDSSRS----SC 396
Query: 595 I 595
I
Sbjct: 397 I 397
Score = 39.3 bits (90), Expect = 0.015
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 20/107 (18%)
Query: 526 GGTCVAP-----NKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSG 580
GG C +P + VC G + D CSE + +S V+ P C +G
Sbjct: 295 GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERL----GNSERVSAPDG---PCPTG 347
Query: 581 FHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSG 627
F ++G SC D+DECA T C N GG+ C+CP G
Sbjct: 348 FE-----RVNG-SCEDVDECA--TGGRCQHGECANTRGGYTCVCPDG 386
Score = 38.9 bits (89), Expect = 0.019
Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 10/78 (12%)
Query: 397 EGPKCG-----ENSECKNWNTKATCECKSGYISVQGDSAYCEDIDEC---AAKMHYCHAN 448
E +CG N C TC C GY + C DI+EC A C N
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPLC-VN 1590
Query: 449 TVCVNLPGLYRCDCVPGY 466
C+N G +RC C PG+
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608
Score = 38.9 bits (89), Expect = 0.019
Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCD--ENAICTNTVQGHSCTC 504
N CV +P + C C GY + + +C + +EC + NA C NT C C
Sbjct: 1545 NGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCIC 1604
Query: 505 KPGY 508
+PG+
Sbjct: 1605 RPGF 1608
Score = 38.5 bits (88), Expect = 0.025
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 519 CEEGCRYGGTCVAPNKCVCPSGFTGSHCE 547
C C GG CV P++C+CP F G C+
Sbjct: 153 CPLICHNGGVCVKPDRCLCPPDFAGKFCQ 181
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYI 467
C +G+ V G CED+DECA H C N G Y C C G++
Sbjct: 344 CPTGFERVNGS---CEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFL 388
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 462 CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
C G+ RV+ SC + DEC +G C ++ C NT G++C C G++
Sbjct: 344 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFL 388
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 521 EGCRYGGTCVAPN--KCVCPSGF----TGSHCEKDIDECSEGIIE---CHNHSRCVNLPG 571
+GC G P C C G+ T C DI+EC E C N +RC+N G
Sbjct: 1541 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVN-ARCLNTDG 1598
Query: 572 WYHCECRSGF 581
+ C CR GF
Sbjct: 1599 SFRCICRPGF 1608
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 129 bits (324), Expect = 1e-29
Identities = 130/477 (27%), Positives = 182/477 (38%), Gaps = 100/477 (20%)
Query: 367 MCPPLNCSEKDHILPENQCC-RVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISV 425
+CPP H+ E+ C + C G C+ P G C C+ GY
Sbjct: 380 LCPPGRTGLLCHL--EDMCLSQPCHGDAQCSTNPLTGST----------LCLCQPGY--- 424
Query: 426 QGDSAYCEDIDECAAKMHY---CHANTVCVNLPGLYRCDCVPGYIRVDDFSC-TEHDECG 481
G + + +D+DEC C C+N PG + C C PGY C +H+EC
Sbjct: 425 SGPTCH-QDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT---GSRCEADHNECL 480
Query: 482 SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEE----GCRYGGTC---VAPNK 534
S C + C + + C C PG G +C E C C + +
Sbjct: 481 S--QPCHPGSTCLDLLATFHCLCPPGL--EGQLCEVETNECASAPCLNHADCHDLLNGFQ 536
Query: 535 CVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC 594
C+C GF+G+ CE+DIDEC C N +C + PG +HC+C GF G C
Sbjct: 537 CICLPGFSGTRCEEDIDECRSS--PCANGGQCQDQPGAFHCKCLPGF--------EGPRC 586
Query: 595 -IDIDECALRTHTCWNDSACINLAGGFDCLCPSG--------PSCSGDCPHEGGLKHNGQ 645
++DEC + C ++C++L G F CLCPSG P C+ + L Q
Sbjct: 587 QTEVDECL--SDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN------LCQPKQ 638
Query: 646 VWTLKEDRCSVCSCKDGKIFCR--RTACDCQNPSADLFCCPECDTRVTS-QCLDQNGHKL 702
+ ++D+ + C C DG C C C + C CD T +C + G
Sbjct: 639 ICKDQKDKAN-CLCPDGSPGCAPPEDNCTCHHGHCQRSSC-VCDVGWTGPECEAELG--- 693
Query: 703 YRSGDNWTHSCQQCRCLEGEVDCWP------LTCPNLSCEYTAILEGECCPRCVSDPCL- 755
C C G C+P TCP YT E C S PCL
Sbjct: 694 ---------GCISAPCAHGGT-CYPQPSGYNCTCPT---GYTGPTCSEEMTACHSGPCLN 740
Query: 756 ---ADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCS--VDFECL 807
+ TC S+ +G + C + C NG C + F CL
Sbjct: 741 GGSCNPSPGGYYCTCPPSH-----TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCL 792
Score = 119 bits (299), Expect = 9e-27
Identities = 130/525 (24%), Positives = 186/525 (35%), Gaps = 135/525 (25%)
Query: 367 MCPPLNCSEKDHILPENQCCRVCRGHNFCAEG---------------------------- 398
+CPP + P+N C+ C +G
Sbjct: 263 LCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQG 322
Query: 399 -PKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGL 457
P C C+N C C SG+ G ++ E++D+C A C + C++ G
Sbjct: 323 PPHCRNGGTCQNSAGSFHCVCVSGW----GGTSCEENLDDCIAAT--CAPGSTCIDRVGS 376
Query: 458 YRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAIC-TNTVQGHS-CTCKPGYVGNGTIC 515
+ C C PG C D C S C +A C TN + G + C C+PGY +G C
Sbjct: 377 FSCLCPPGR---TGLLCHLEDMCLS--QPCHGDAQCSTNPLTGSTLCLCQPGY--SGPTC 429
Query: 516 RAFCEE---------GCRYGGTCV---APNKCVCPSGFTGSHCEKDIDECSEGIIECHNH 563
+E C +GG+C+ C+CP G+TGS CE D +EC CH
Sbjct: 430 HQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQ--PCHPG 487
Query: 564 SRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLAGGFDC 622
S C++L +HC C G L G+ C ++ +ECA + C N + C +L GF C
Sbjct: 488 STCLDLLATFHCLCPPG--------LEGQLCEVETNECA--SAPCLNHADCHDLLNGFQC 537
Query: 623 LCP---SGPSC--------------SGDCPHEGGLKH-------NGQVWTLKEDRCSVCS 658
+C SG C G C + G H G + D C
Sbjct: 538 ICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDP 597
Query: 659 CKDGKIFCRRTACDCQNPSADLFC-CPE------CDTRVTSQCLDQNGHKLYRSGDNWTH 711
C G C + FC CP C+ + + L Q D
Sbjct: 598 CPVG--------ASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDK--- 646
Query: 712 SCQQCRCLEGEVDCWP----LTCPNLSCEYTAIL-----EGECCPR----CVSDPCLADN 758
C C +G C P TC + C+ ++ + G C C+S PC
Sbjct: 647 --ANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGG 704
Query: 759 ITY----DIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 799
Y TC Y +G + + C + C NG C
Sbjct: 705 TCYPQPSGYNCTCPTGY-----TGPTCSEEMTACHSGPCLNGGSC 744
Score = 119 bits (297), Expect = 1e-26
Identities = 118/444 (26%), Positives = 159/444 (35%), Gaps = 99/444 (22%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGY--------ISVQGDSAYCEDIDECAAKMHY 444
+ CA+ P C NS C C C G+ +S +A + ID +
Sbjct: 846 DLCAQKP-CPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSL---- 900
Query: 445 CHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCT 503
CH +CV+ Y C C PG+ C +H + C S C A C G+ C
Sbjct: 901 CHNGGLCVDSGPSYFCHCPPGF---QGSLCQDHVNPCES--RPCQNGATCMAQPSGYLCQ 955
Query: 504 CKPGYVGNGTICR--AFCEEGCRYGGTCVAPN---KCVCPSGFTGSHCEKDIDECSEGII 558
C PGY G A + C GTC C CP GF G CE D+DEC +
Sbjct: 956 CAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPC 1015
Query: 559 ECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESC-IDIDECALRTHTCWNDSACINLA 617
+ C +L ++C+C G +G+ C ++ID C + C++ C A
Sbjct: 1016 HPTGTAACHSLANAFYCQCLPGH--------TGQWCEVEIDPC--HSQPCFHGGTCEATA 1065
Query: 618 G---GFDCLCP---SGPSCSGDCP-------HEGGLKHNGQVWTLKEDRCSVCSCKDGKI 664
G GF C CP GP+CS P H GGL + + K C+C G
Sbjct: 1066 GSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGL----CLPSPKPGFPPRCACLSG-- 1119
Query: 665 FCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNG-----------HKL----------- 702
DC P A C P C + G H
Sbjct: 1120 ---YGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAK 1176
Query: 703 ---YRSGD------------NWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCP 747
RSGD NW C G D W CP+ S + +G+C P
Sbjct: 1177 GCEGRSGDGACDAGCSGPGGNWDGG----DCSLGVPDPWK-GCPSHSRCWLLFRDGQCHP 1231
Query: 748 RCVSDPCLADNITYDIRKTCLDSY 771
+C S+ CL D + C +Y
Sbjct: 1232 QCDSEECLFDGYDCETPPACTPAY 1255
Score = 105 bits (263), Expect = 1e-22
Identities = 142/587 (24%), Positives = 199/587 (33%), Gaps = 152/587 (25%)
Query: 296 TCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRE 355
TC EC P C ++ G +C P G + A+ L++ C
Sbjct: 428 TCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCEADHNECLSQPCHP 486
Query: 356 CRG--GVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTK 413
+L +CPP E Q C V N CA P C +++C +
Sbjct: 487 GSTCLDLLATFHCLCPPGL---------EGQLCEV--ETNECASAP-CLNHADCHDLLNG 534
Query: 414 ATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFS 473
C C G+ + + EDIDEC + C C + PG + C C+PG+ +
Sbjct: 535 FQCICLPGFSGTRCE----EDIDECRSSP--CANGGQCQDQPGAFHCKCLPGF---EGPR 585
Query: 474 C-TEHDECGS-------------------------GQ---------HNCDENAICTNTVQ 498
C TE DEC S GQ + C IC +
Sbjct: 586 CQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKD 645
Query: 499 GHSCTCKPGYVG------NGTICRAFCEEG------------------------CRYGGT 528
+C C G G N T C+ C +GGT
Sbjct: 646 KANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGT 705
Query: 529 CV---APNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDG 585
C + C CP+G+TG C +++ C G C N C PG Y+C C H
Sbjct: 706 CYPQPSGYNCTCPTGYTGPTCSEEMTACHSG--PCLNGGSCNPSPGGYYCTCPPS-HTGP 762
Query: 586 TYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCP---SGPSCSGDCPHEGGLKH 642
S + C+ C+N C+N G F CLC GP C EG L+
Sbjct: 763 QCQTSTDYCVSAP--------CFNGGTCVNRPGTFSCLCAMGFQGPRC------EGKLRP 808
Query: 643 NGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCL------- 695
SC D CR A +P CP T + Q L
Sbjct: 809 ---------------SCADSP--CRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK 851
Query: 696 --DQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL-TCPNLSCEYTAILEGECCPRCVSD 752
+N H L ++G ++ C CL+G PL P SC+ A+ +G VS
Sbjct: 852 PCPRNSHCL-QTGPSF-----HCLCLQGWTG--PLCNLPLSSCQKAALSQGID----VSS 899
Query: 753 PCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 799
C + D + + GS+ +PC + C+NG C
Sbjct: 900 LCHNGGLCVDSGPSYF-CHCPPGFQGSLCQDHVNPCESRPCQNGATC 945
Score = 87.0 bits (214), Expect = 6e-17
Identities = 89/372 (23%), Positives = 131/372 (35%), Gaps = 64/372 (17%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTV---- 450
C P C C + C C +GY C+ +M CH+
Sbjct: 695 CISAP-CAHGGTCYPQPSGYNCTCPTGYTG-----------PTCSEEMTACHSGPCLNGG 742
Query: 451 -CVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV 509
C PG Y C C P + + T++ C S C C N SC C G+
Sbjct: 743 SCNPSPGGYYCTCPPSHTGPQCQTSTDY--CVSAP--CFNGGTCVNRPGTFSCLCAMGFQ 798
Query: 510 G---NGTICRAFCEEGCRYGGTCV-APN--KCVCPSGFTGSHCEKDIDECSEGIIECHNH 563
G G + + + CR TC +P +C+CP+G+TG C+ +D C++ C +
Sbjct: 799 GPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK--PCPRN 856
Query: 564 SRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALR-----THTCWNDSACINLAG 618
S C+ +HC C G+ T L + AL + C N C++
Sbjct: 857 SHCLQTGPSFHCLCLQGW----TGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP 912
Query: 619 GFDCLCP---SGPSCSGDC-PHEGGLKHNGQVWTLKEDRCSVCSCKDG--KIFCRRTACD 672
+ C CP G C P E NG + + +C C G C +
Sbjct: 913 SYFCHCPPGFQGSLCQDHVNPCESRPCQNGAT-CMAQPSGYLCQCAPGYDGQNCSKELDA 971
Query: 673 CQN------------PSADLFCCP------ECDTRVTSQCLDQNGHKLYRSGDNWTHSCQ 714
CQ+ P CP C+ V +CLDQ H + + +
Sbjct: 972 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDV-DECLDQPCHPTGTAACHSLANAF 1030
Query: 715 QCRCLEGEVDCW 726
C+CL G W
Sbjct: 1031 YCQCLPGHTGQW 1042
Score = 85.5 bits (210), Expect = 2e-16
Identities = 124/542 (22%), Positives = 173/542 (31%), Gaps = 139/542 (25%)
Query: 385 CCRVCRGHNF-CAEGPK-CGENSECKNWNT-KATCECKSGYISVQGDSAYCEDIDECAAK 441
C V R C P+ C C + + + TC+C G++ G++ C+ D C
Sbjct: 17 CVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFL---GET--CQFPDPCQ-N 70
Query: 442 MHYCHANTVC-------VNLPGL-------YRCDCVPGYIRVDDFSCTEHDECGSGQHNC 487
C C + LP + C C+PG+ C E C
Sbjct: 71 AQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGE---RCQAKLEDPCPPSFC 127
Query: 488 DENAICTNTVQGH-SCTCKPGYVGNGTICRAFCEEG-CRYGGTCVAPN---KCVCPSGFT 542
+ C G C+C PG+ G R FC C GG C+A +C CP GF
Sbjct: 128 SKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFE 187
Query: 543 GSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGF--------------------- 581
G CE+D++EC + C + C N G + C C G
Sbjct: 188 GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGG 247
Query: 582 ------HDDGTYSLS-------GESC-IDIDECALRTHTCWNDSACINLAGGFDCLCP-- 625
D T+ L G C ++ D C +H C N C + + CLCP
Sbjct: 248 TCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCV--SHQCQNGGTCQDGLDTYTCLCPET 305
Query: 626 -SGPSCS-----------------GDCPHEGGLKH-------NGQVWTLKEDRCSVCSCK 660
+G CS G C + G H G D C +C
Sbjct: 306 WTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCA 365
Query: 661 DGKIFCRRT---ACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCR 717
G R +C C L C + CL Q H + N C
Sbjct: 366 PGSTCIDRVGSFSCLCPPGRTGLLC------HLEDMCLSQPCHGDAQCSTNPLTGSTLCL 419
Query: 718 CLEGEV---------DC-----WPLTCPN-LSCEYTAILEGECCP-------------RC 749
C G +C P C + SC T CP C
Sbjct: 420 CQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC 479
Query: 750 VSDPCLADNITYDIRKT--CLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSV--DFE 805
+S PC + D+ T CL G L G + + + C + C N C + F+
Sbjct: 480 LSQPCHPGSTCLDLLATFHCLCPPG---LEGQLCEVETNECASAPCLNHADCHDLLNGFQ 536
Query: 806 CL 807
C+
Sbjct: 537 CI 538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.477
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,264,476
Number of Sequences: 37866
Number of extensions: 2075695
Number of successful extensions: 11331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 4250
Number of HSP's gapped (non-prelim): 2558
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.