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Search of human proteins with 222080092
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222080092 WD repeat domain 91 [Homo sapiens]
(747 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222080092 WD repeat domain 91 [Homo sapiens] 1513 0.0
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 60 1e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 58 3e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 58 3e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 58 3e-08
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 56 1e-07
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 56 1e-07
gi|13376840 WD repeat domain 61 [Homo sapiens] 56 1e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 56 1e-07
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 55 2e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 55 2e-07
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 55 2e-07
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 55 2e-07
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 54 4e-07
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 54 4e-07
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 54 4e-07
gi|18874090 WD repeat domain 48 [Homo sapiens] 54 4e-07
gi|156151430 armadillo repeat containing 9 [Homo sapiens] 54 4e-07
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 54 5e-07
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 54 7e-07
gi|16554629 WD repeat domain 5 [Homo sapiens] 53 1e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 53 1e-06
gi|32189425 WD repeat domain 69 [Homo sapiens] 50 6e-06
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 50 6e-06
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 50 8e-06
gi|34996489 pleckstrin homology domain interacting protein [Homo... 50 1e-05
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 49 1e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 49 1e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 49 1e-05
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 49 1e-05
>gi|222080092 WD repeat domain 91 [Homo sapiens]
Length = 747
Score = 1513 bits (3916), Expect = 0.0
Identities = 747/747 (100%), Positives = 747/747 (100%)
Query: 1 MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAA 60
MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAA
Sbjct: 1 MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAA 60
Query: 61 LRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQ 120
LRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQ
Sbjct: 61 LRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQ 120
Query: 121 NQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDA 180
NQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDA
Sbjct: 121 NQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDA 180
Query: 181 ECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDS 240
ECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDS
Sbjct: 181 ECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDS 240
Query: 241 ELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTK 300
ELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTK
Sbjct: 241 ELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTK 300
Query: 301 GKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASG 360
GKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASG
Sbjct: 301 GKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASG 360
Query: 361 PEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSG 420
PEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSG
Sbjct: 361 PEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSG 420
Query: 421 RRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDT 480
RRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDT
Sbjct: 421 RRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDT 480
Query: 481 EAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPG 540
EAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPG
Sbjct: 481 EAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPG 540
Query: 541 RLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW 600
RLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW
Sbjct: 541 RLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW 600
Query: 601 RAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSG 660
RAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSG
Sbjct: 601 RAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSG 660
Query: 661 YKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWS 720
YKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWS
Sbjct: 661 YKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWS 720
Query: 721 TAMDCGTCLTASMDGKIKLTTLLAHKA 747
TAMDCGTCLTASMDGKIKLTTLLAHKA
Sbjct: 721 TAMDCGTCLTASMDGKIKLTTLLAHKA 747
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/388 (22%), Positives = 144/388 (37%), Gaps = 95/388 (24%)
Query: 404 YGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISK-------SPLLSL 456
Y EH ++ + SG +AS DV G +++W T+ + K + +
Sbjct: 54 YTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWD-----TTQKEHLLKYEYQPFAGKIKDI 108
Query: 457 EWATKRDRLLLLGSG---VGTVRLYD--------TEAKKNLCEININDNMPRILSLACSP 505
W R+ ++G G G V L+D T K + ++I + P L+
Sbjct: 109 AWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDD 168
Query: 506 NGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAI 565
N A+F F P + +F++ +
Sbjct: 169 NCAAF--------------FEGPPF----------------------KFKFTIGDHSRFV 192
Query: 566 NCTAFNHNGNLLVTGAADGVIRLFDMQQHE--CAMSW-RAHYGEVYSVEFSYDENTVYSI 622
NC F+ +GN T +ADG I ++D + E CA+ +AH G +Y++ +S D + S
Sbjct: 193 NCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSA 252
Query: 623 GEDGKFIQWNIHKSGLKVSEYSLPS-------------DATGPFVLSGYSGYKQVQVPRG 669
D W++ + + VS + + S D LSGY Y P
Sbjct: 253 SGDKTSKIWDVSVNSV-VSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSK 311
Query: 670 RLFAF--DSEGNYMLTCSATGGVIYKLGG---------DEKVLESCLSLG-GHRAPV--V 715
L S+ LT GG Y G D + E+ G GH V +
Sbjct: 312 PLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRM 371
Query: 716 TVDWSTAMDCGTCLTASMDGKIKLTTLL 743
TVD + G ++ SMD ++ T+L+
Sbjct: 372 TVD-----ESGQLISCSMDDTVRYTSLM 394
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.2 bits (139), Expect = 3e-08
Identities = 73/325 (22%), Positives = 125/325 (38%), Gaps = 61/325 (18%)
Query: 401 QEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAT 460
+ + H ++ + +++AS +D + VW P + + K + + ++
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 461 KRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLT 520
LL GS TVR++ K + R + CS +G SFV A+ T
Sbjct: 72 S-GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CS-DGQSFV--TASDDKT 126
Query: 521 SQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTG 580
+V W T +Q+ FSL + C F+ +G L+V+
Sbjct: 127 VKV---------------------WATH--RQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163
Query: 581 AADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKV 640
+ D ++L+D EC S+ H G V V+F + + G D W++ L +
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL-L 222
Query: 641 SEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKV 700
Y L S A ++G S F GNY++T S+ + K+
Sbjct: 223 QHYQLHSAA-----VNGLS--------------FHPSGNYLITASSDSTL--------KI 255
Query: 701 LE-----SCLSLGGHRAPVVTVDWS 720
L+ +L GH+ P TV +S
Sbjct: 256 LDLMEGRLLYTLHGHQGPATTVAFS 280
Score = 49.3 bits (116), Expect = 1e-05
Identities = 50/247 (20%), Positives = 101/247 (40%), Gaps = 30/247 (12%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H ++ SG +AS D +++W N ++ + + S+ + + +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSF 118
Query: 467 LLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSL------- 519
+ S TV+++ T +K L ++ + N R SP+G V ++ ++
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF--SPDGRLIVSASDDKTVKLWDKSS 176
Query: 520 -------------TSQVDF--SAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIA 564
+ VDF S I + GM+ + +WD +T + + L A
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT---VKVWDVRTHRLLQHYQL--HSAA 231
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
+N +F+ +GN L+T ++D +++ D+ + + H G +V FS S G
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 625 DGKFIQW 631
D + + W
Sbjct: 292 DEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.2 bits (139), Expect = 3e-08
Identities = 73/325 (22%), Positives = 125/325 (38%), Gaps = 61/325 (18%)
Query: 401 QEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAT 460
+ + H ++ + +++AS +D + VW P + + K + + ++
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 461 KRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLT 520
LL GS TVR++ K + R + CS +G SFV A+ T
Sbjct: 72 S-GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CS-DGQSFV--TASDDKT 126
Query: 521 SQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTG 580
+V W T +Q+ FSL + C F+ +G L+V+
Sbjct: 127 VKV---------------------WATH--RQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163
Query: 581 AADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKV 640
+ D ++L+D EC S+ H G V V+F + + G D W++ L +
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL-L 222
Query: 641 SEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKV 700
Y L S A ++G S F GNY++T S+ + K+
Sbjct: 223 QHYQLHSAA-----VNGLS--------------FHPSGNYLITASSDSTL--------KI 255
Query: 701 LE-----SCLSLGGHRAPVVTVDWS 720
L+ +L GH+ P TV +S
Sbjct: 256 LDLMEGRLLYTLHGHQGPATTVAFS 280
Score = 49.3 bits (116), Expect = 1e-05
Identities = 50/247 (20%), Positives = 101/247 (40%), Gaps = 30/247 (12%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H ++ SG +AS D +++W N ++ + + S+ + + +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSF 118
Query: 467 LLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSL------- 519
+ S TV+++ T +K L ++ + N R SP+G V ++ ++
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF--SPDGRLIVSASDDKTVKLWDKSS 176
Query: 520 -------------TSQVDF--SAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIA 564
+ VDF S I + GM+ + +WD +T + + L A
Sbjct: 177 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT---VKVWDVRTHRLLQHYQL--HSAA 231
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
+N +F+ +GN L+T ++D +++ D+ + + H G +V FS S G
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 625 DGKFIQW 631
D + + W
Sbjct: 292 DEQVMVW 298
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 58.2 bits (139), Expect = 3e-08
Identities = 53/241 (21%), Positives = 101/241 (41%), Gaps = 33/241 (13%)
Query: 403 EYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKR 462
E+ H + + G+ +A+ D IKVWS + S + + +
Sbjct: 97 EFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR-QRFLYSLYRHTHWVRCAKFSPD 155
Query: 463 DRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQ 522
RL++ S T++++DT K+ C N +D++ + +P+G
Sbjct: 156 GRLIVSCSEDKTIKIWDTTNKQ--CVNNFSDSVGFANFVDFNPSGTC------------- 200
Query: 523 VDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAA 582
I S G +Q + +WD + K + + +NC +F+ +GN L+T ++
Sbjct: 201 -------IASAGSDQT---VKVWDVRVNKLLQHYQVHSG--GVNCISFHPSGNYLITASS 248
Query: 583 DGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQW-----NIHKSG 637
DG +++ D+ + + + H G V++V FS S G D + + W +H G
Sbjct: 249 DGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKG 308
Query: 638 L 638
L
Sbjct: 309 L 309
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/319 (20%), Positives = 121/319 (37%), Gaps = 61/319 (19%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H ++I + +G+++A+ D + +W+F P + K + S++++ LL
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP-HGNLL 75
Query: 467 LLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFS 526
S TVRL+ + + E + AP VDFS
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAH----------------------TAP--VRSVDFS 111
Query: 527 APDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVI 586
A D + +W +Q+ +SL + C F+ +G L+V+ + D I
Sbjct: 112 A-DGQFLATASEDKSIKVWSM--YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
Query: 587 RLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLP 646
+++D +C ++ G V+F+ + S G D W++ + L + Y +
Sbjct: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL-LQHYQVH 227
Query: 647 SDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLE---- 702
S +F GNY++T S+ G + K+L+
Sbjct: 228 SGGVN-------------------CISFHPSGNYLITASSDGTL--------KILDLLEG 260
Query: 703 -SCLSLGGHRAPVVTVDWS 720
+L GH PV TV +S
Sbjct: 261 RLIYTLQGHTGPVFTVSFS 279
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/258 (20%), Positives = 111/258 (43%), Gaps = 43/258 (16%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLE--------- 457
H +S+ HCR + +AS DG +K+W + K+ ++ K L+LE
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVI 800
Query: 458 -----WATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASF-- 510
W+ R+++ + L++T+++ + + ++ + + SP+G+SF
Sbjct: 801 VKCCSWSADGARIMVAAKN--KIFLWNTDSRSKVADCR--GHLSWVHGVMFSPDGSSFLT 856
Query: 511 --------------VCSAAAPSLTSQVD--FSAPDIGSKGMNQVPGRLLLWDTKTMKQQL 554
VC +A L +VD F ++ ++ + RL L + +T Q+
Sbjct: 857 SSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIR-RLQLINGRT--GQI 913
Query: 555 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSY 614
+ + + ++C + + + G +G I + ++ + S H V+ ++F+
Sbjct: 914 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 970
Query: 615 DENTVYSIGEDGKFIQWN 632
DE T+ S +D + WN
Sbjct: 971 DEKTLISSSDDAEIQVWN 988
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/97 (27%), Positives = 48/97 (49%), Gaps = 4/97 (4%)
Query: 538 VPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGN--LLVTGAADGVIRLFDMQQHE 595
V ++ +W++ T +L + D +NC F ++ + LL TG++D ++L+D+ Q E
Sbjct: 677 VDKKVKIWNSMT--GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734
Query: 596 CAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 632
C + H V FS D+ + S DG W+
Sbjct: 735 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/73 (26%), Positives = 33/73 (45%)
Query: 560 PEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTV 619
P A+ F+ +G + + AD +++F + E + +AH EV FS D+ +
Sbjct: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 672
Query: 620 YSIGEDGKFIQWN 632
+ D K WN
Sbjct: 673 ATCSVDKKVKIWN 685
Score = 31.6 bits (70), Expect = 2.8
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 10/77 (12%)
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQ----HECA----MSWRAHYGEVYSVEFSYDE 616
+ C+AF+ + LL TG +G IR++++ H CA H G V + FS D
Sbjct: 1087 VRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1146
Query: 617 NTVYSIGEDGKFIQWNI 633
+ S G G WN+
Sbjct: 1147 KMLISAG--GYIKWWNV 1161
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/258 (20%), Positives = 111/258 (43%), Gaps = 43/258 (16%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLE--------- 457
H +S+ HCR + +AS DG +K+W + K+ ++ K L+LE
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVI 789
Query: 458 -----WATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASF-- 510
W+ R+++ + L++T+++ + + ++ + + SP+G+SF
Sbjct: 790 VKCCSWSADGARIMVAAKN--KIFLWNTDSRSKVADCR--GHLSWVHGVMFSPDGSSFLT 845
Query: 511 --------------VCSAAAPSLTSQVD--FSAPDIGSKGMNQVPGRLLLWDTKTMKQQL 554
VC +A L +VD F ++ ++ + RL L + +T Q+
Sbjct: 846 SSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIR-RLQLINGRT--GQI 902
Query: 555 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSY 614
+ + + ++C + + + G +G I + ++ + S H V+ ++F+
Sbjct: 903 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 959
Query: 615 DENTVYSIGEDGKFIQWN 632
DE T+ S +D + WN
Sbjct: 960 DEKTLISSSDDAEIQVWN 977
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/97 (27%), Positives = 48/97 (49%), Gaps = 4/97 (4%)
Query: 538 VPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGN--LLVTGAADGVIRLFDMQQHE 595
V ++ +W++ T +L + D +NC F ++ + LL TG++D ++L+D+ Q E
Sbjct: 666 VDKKVKIWNSMT--GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
Query: 596 CAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 632
C + H V FS D+ + S DG W+
Sbjct: 724 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 35.4 bits (80), Expect = 0.19
Identities = 19/73 (26%), Positives = 33/73 (45%)
Query: 560 PEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTV 619
P A+ F+ +G + + AD +++F + E + +AH EV FS D+ +
Sbjct: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
Query: 620 YSIGEDGKFIQWN 632
+ D K WN
Sbjct: 662 ATCSVDKKVKIWN 674
Score = 31.6 bits (70), Expect = 2.8
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 10/77 (12%)
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQ----HECA----MSWRAHYGEVYSVEFSYDE 616
+ C+AF+ + LL TG +G IR++++ H CA H G V + FS D
Sbjct: 1076 VRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDG 1135
Query: 617 NTVYSIGEDGKFIQWNI 633
+ S G G WN+
Sbjct: 1136 KMLISAG--GYIKWWNV 1150
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 56.2 bits (134), Expect = 1e-07
Identities = 55/211 (26%), Positives = 91/211 (43%), Gaps = 30/211 (14%)
Query: 424 ASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRD-RLLLLGSGVGTVRLYDTEA 482
AS +D I++W Q K SI P+ + A D + L G+ VG V ++ E+
Sbjct: 80 ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
Query: 483 KKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRL 542
K E +++ ILS+A SP+G ++ S A + G +
Sbjct: 138 GKK--EYSLDTRGKFILSIAYSPDG-KYLASGA----------------------IDGII 172
Query: 543 LLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRA 602
++D T K L +L+ + I F+ + LLVT + DG I+++D+Q A +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 603 HYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
H V +V F D+ S D W++
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 44.7 bits (104), Expect = 3e-04
Identities = 47/216 (21%), Positives = 91/216 (42%), Gaps = 26/216 (12%)
Query: 423 VASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEA 482
V + +D ++KVW + + L L+W+ + +L GV +V + T
Sbjct: 35 VVTGSLDDLVKVWKW------------RDERLDLQWSLEGHQL-----GVVSVDISHT-- 75
Query: 483 KKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRL 542
I + ++ + L NG A P + FS PD G++
Sbjct: 76 ----LPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS-PDSQYLATGTHVGKV 130
Query: 543 LLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRA 602
++ ++ K++ +SLD I A++ +G L +GA DG+I +FD+ + +
Sbjct: 131 NIFGVESGKKE--YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
Query: 603 HYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGL 638
H + S+ FS D + + +DG +++ + L
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
Score = 32.7 bits (73), Expect = 1.3
Identities = 47/191 (24%), Positives = 75/191 (39%), Gaps = 29/191 (15%)
Query: 573 NGNLLVTGAADGVIRLFDMQQHECAMSW--RAHYGEVYSVEFSYDENTVYSIGEDGKFIQ 630
N +VTG+ D +++++ + + W H V SV+ S+ S D
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 631 WNIHKSGLKVSEYSLPSD-------------ATGPFV-----LSGYSGYKQVQV-PRGRL 671
W++ S + P D ATG V SG K+ + RG+
Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Query: 672 ---FAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTC 728
A+ +G Y L A G+I D + +L GH P+ ++ +S D
Sbjct: 151 ILSIAYSPDGKY-LASGAIDGIINIF--DIATGKLLHTLEGHAMPIRSLTFSP--DSQLL 205
Query: 729 LTASMDGKIKL 739
+TAS DG IK+
Sbjct: 206 VTASDDGYIKI 216
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 55.8 bits (133), Expect = 1e-07
Identities = 57/217 (26%), Positives = 93/217 (42%), Gaps = 28/217 (12%)
Query: 419 SGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLY 478
SGR +A+ D + +WS N + + SP+ S+ T + L++ GS G++R++
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEE-LIVAGSQSGSIRVW 90
Query: 479 DTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQV 538
D EA K L + + I SL P G FV S GS+ N
Sbjct: 91 DLEAAKILR--TLMGHKANICSLDFHPYG-EFVAS-----------------GSQDTN-- 128
Query: 539 PGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAM 598
+ LWD + ++ F A+ C F+ +G L + A D ++L+D+ +
Sbjct: 129 ---IKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
Query: 599 SWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHK 635
+ H G V VEF +E + S D W++ K
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 55.5 bits (132), Expect = 2e-07
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 33/177 (18%)
Query: 549 TMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVY 608
T +Q+ FSL + C F+ +G L+V+ + D ++L+D EC S+ H G V
Sbjct: 94 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 153
Query: 609 SVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPR 668
V+F + + G D W++ L + Y L S A ++G S
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRL-LQHYQLHSAA-----VNGLS--------- 198
Query: 669 GRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLE-----SCLSLGGHRAPVVTVDWS 720
F GNY++T S+ + K+L+ +L GH+ P TV +S
Sbjct: 199 -----FHPSGNYLITASSDSTL--------KILDLMEGRLLYTLHGHQGPATTVAFS 242
Score = 49.3 bits (116), Expect = 1e-05
Identities = 50/247 (20%), Positives = 101/247 (40%), Gaps = 30/247 (12%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H ++ SG +AS D +++W N ++ + + S+ + + +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD-GQSF 80
Query: 467 LLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSL------- 519
+ S TV+++ T +K L ++ + N R SP+G V ++ ++
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF--SPDGRLIVSASDDKTVKLWDKSS 138
Query: 520 -------------TSQVDF--SAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIA 564
+ VDF S I + GM+ + +WD +T + + L A
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT---VKVWDVRTHRLLQHYQL--HSAA 193
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
+N +F+ +GN L+T ++D +++ D+ + + H G +V FS S G
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 625 DGKFIQW 631
D + + W
Sbjct: 254 DEQVMVW 260
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 55.5 bits (132), Expect = 2e-07
Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
+NCT F+ N N + TG+AD +RL+D+ C + H G ++S+ FS + + +
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
Query: 625 DGKFIQWNIHKSGLKVSE 642
DG+ + W+I GL V E
Sbjct: 690 DGRVLLWDI-GHGLMVGE 706
Score = 36.2 bits (82), Expect = 0.11
Identities = 22/72 (30%), Positives = 32/72 (44%)
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
I+ F+ NG L TGA DG + L+D+ + H V S+ FS D + S
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM 731
Query: 625 DGKFIQWNIHKS 636
D W+ K+
Sbjct: 732 DNTVRLWDAIKA 743
Score = 34.7 bits (78), Expect = 0.33
Identities = 13/45 (28%), Positives = 27/45 (60%)
Query: 569 AFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFS 613
+F+ + N L++ + DG +RL+ +Q C + ++ H V+ +FS
Sbjct: 550 SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/257 (22%), Positives = 106/257 (41%), Gaps = 40/257 (15%)
Query: 405 GEHHSSIMHCRVDCS---------GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLS 455
G H +HCR + S +++ S D IK+W N + + + +L
Sbjct: 253 GRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLC 312
Query: 456 LEWATKRDRLLLLGSGVGTVRLYDTEAKKNL------CEININDNMPRILSLACSPNGAS 509
L++ +R+++ GS TVR++D + L CE ++ + + CS + +
Sbjct: 313 LQYD---ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSI 369
Query: 510 FVCSAAAPS-------------LTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQF 556
V A+P+ + VDF I S ++ + +W+T T +
Sbjct: 370 AVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRT---IKVWNTSTC--EFVR 424
Query: 557 SLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDE 616
+L+ I C + L+V+G++D IRL+D++ C H V + F D
Sbjct: 425 TLNGHKRGIAC--LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 480
Query: 617 NTVYSIGEDGKFIQWNI 633
+ S DGK W++
Sbjct: 481 KRIVSGAYDGKIKVWDL 497
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/257 (22%), Positives = 106/257 (41%), Gaps = 40/257 (15%)
Query: 405 GEHHSSIMHCRVDCS---------GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLS 455
G H +HCR + S +++ S D IK+W N + + + +L
Sbjct: 289 GRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLC 348
Query: 456 LEWATKRDRLLLLGSGVGTVRLYDTEAKKNL------CEININDNMPRILSLACSPNGAS 509
L++ +R+++ GS TVR++D + L CE ++ + + CS + +
Sbjct: 349 LQYD---ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSI 405
Query: 510 FVCSAAAPS-------------LTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQF 556
V A+P+ + VDF I S ++ + +W+T T +
Sbjct: 406 AVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRT---IKVWNTSTC--EFVR 460
Query: 557 SLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDE 616
+L+ I C + L+V+G++D IRL+D++ C H V + F D
Sbjct: 461 TLNGHKRGIAC--LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 516
Query: 617 NTVYSIGEDGKFIQWNI 633
+ S DGK W++
Sbjct: 517 KRIVSGAYDGKIKVWDL 533
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 8/113 (7%)
Query: 541 RLLLWDTKTMK-QQLQFSLDPEPIAINCTAFN-HNGNLLVTGAADGVIRLFDMQQHECAM 598
+L++WDT++ + S+D +NC +FN ++ +L TG+AD + L+D++ + +
Sbjct: 216 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 275
Query: 599 -SWRAHYGEVYSVEFS-YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDA 649
S+ +H E++ V++S ++E + S G D + W++ K G E P DA
Sbjct: 276 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG----EEQSPEDA 324
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 8/113 (7%)
Query: 541 RLLLWDTKTMK-QQLQFSLDPEPIAINCTAFN-HNGNLLVTGAADGVIRLFDMQQHECAM 598
+L++WDT++ + S+D +NC +FN ++ +L TG+AD + L+D++ + +
Sbjct: 250 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 309
Query: 599 -SWRAHYGEVYSVEFS-YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDA 649
S+ +H E++ V++S ++E + S G D + W++ K G E P DA
Sbjct: 310 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG----EEQSPEDA 358
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/113 (29%), Positives = 64/113 (56%), Gaps = 8/113 (7%)
Query: 541 RLLLWDTKTMK-QQLQFSLDPEPIAINCTAFN-HNGNLLVTGAADGVIRLFDMQQHECAM 598
+L++WDT++ + S+D +NC +FN ++ +L TG+AD + L+D++ + +
Sbjct: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310
Query: 599 -SWRAHYGEVYSVEFS-YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDA 649
S+ +H E++ V++S ++E + S G D + W++ K G E P DA
Sbjct: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG----EEQSPEDA 359
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 54.3 bits (129), Expect = 4e-07
Identities = 54/244 (22%), Positives = 105/244 (43%), Gaps = 36/244 (14%)
Query: 406 EHHSSIMHCRV-DCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDR 464
EHH+ ++ V C+G+ + S D +KVW+ + K + +L +A +D+
Sbjct: 72 EHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYA--KDK 129
Query: 465 LLLLGSGVGT-VRLYD-------TEAKKNLCEININDNMPRILSLACSPNGASFVCSAAA 516
L+ +G+ + L+D T + + +++ N I SLA + G V +
Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGS-- 187
Query: 517 PSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNL 576
T +V L +WD +T + ++ L + N +G
Sbjct: 188 ---TEKV------------------LRVWDPRTCAKLMK--LKGHTDNVKALLLNRDGTQ 224
Query: 577 LVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKS 636
++G++DG IRL+ + Q C ++R H V++++ + VYS G D K ++
Sbjct: 225 CLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNP 284
Query: 637 GLKV 640
++V
Sbjct: 285 DIRV 288
Score = 34.7 bits (78), Expect = 0.33
Identities = 50/203 (24%), Positives = 70/203 (34%), Gaps = 41/203 (20%)
Query: 575 NLLVTGAADGVIRLFDMQQHE---CAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQW 631
N L T D +IR++ + QH+ S H V + + T+ S D W
Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102
Query: 632 NIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRG-----------RLFAFDSEGNY 680
N HK G +S D Y+ K++ G L A + N
Sbjct: 103 NAHK-GFCMSTLRTHKDYVKAL---AYAKDKELVASAGLDRQIFLWDVNTLTALTASNNT 158
Query: 681 MLTCSATG-------------GVIYKLGGDEKVLE--------SCLSLGGHRAPVVTVDW 719
+ T S +G G I G EKVL + L GH V +
Sbjct: 159 VTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKAL-- 216
Query: 720 STAMDCGTCLTASMDGKIKLTTL 742
D CL+ S DG I+L +L
Sbjct: 217 LLNRDGTQCLSGSSDGTIRLWSL 239
>gi|156151430 armadillo repeat containing 9 [Homo sapiens]
Length = 665
Score = 54.3 bits (129), Expect = 4e-07
Identities = 47/205 (22%), Positives = 85/205 (41%), Gaps = 24/205 (11%)
Query: 11 LVREYLLFRGFTHTLRQLDAEIKADKEK-------GFRVDKIVDQLQQLMQVYDLAALRD 63
LV+EYL F F TL+ E K + FR K + + L+ +D +
Sbjct: 14 LVKEYLDFAEFEDTLKTFSKECKIKGKPLCKTVGGSFRDSKSLTIQKDLVAAFDNGDQKV 73
Query: 64 YWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQ--TNRNDKAQ---------EFF 112
++ E + S + D KL+ L + +Y ++ R DK + +
Sbjct: 74 FFDLWEEHISSSIRD-GDSFAQKLEFYLHIHFAIYLLKYSVGRPDKEELDEKISYFKTYL 132
Query: 113 AKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPV 172
+ L E+ ++ LPF+P+P +P+F F W + L FL+++ +
Sbjct: 133 ETKGAALSQTTEFLPFYALPFVPNPMVHPSFKELFQDSWTPELKLKLEKFLALISKASNT 192
Query: 173 PVILNFDAECQRTNQVQEENEVLRQ 197
P +L E ++N+ E+L+Q
Sbjct: 193 PKLLTIYKENGQSNK-----EILQQ 212
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 53.9 bits (128), Expect = 5e-07
Identities = 53/226 (23%), Positives = 88/226 (38%), Gaps = 29/226 (12%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H ++ C G VAS +D K+W N + S+E+ + LL
Sbjct: 435 HSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL 494
Query: 467 LLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFS 526
S T+ ++D A+ +CE ++ +M I P G + S A +T
Sbjct: 495 T-SSADKTLSIWD--ARTGICEQSLYGHMHSINDAIFDPRG-HMIASCDACGVTK----- 545
Query: 527 APDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVI 586
LWD + + + + P P N F+ +G +L + +GVI
Sbjct: 546 -----------------LWDFRKLLPIVSIDIGPSPG--NEVNFDSSGRVLAQASGNGVI 586
Query: 587 RLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 632
L D++ E H E ++V FS+D ++S G DG W+
Sbjct: 587 HLLDLKSGEIH-KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 38.5 bits (88), Expect = 0.023
Identities = 26/82 (31%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 401 QEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAT 460
Q YG HS I D G +AS D GV K+W F ++ + I SP + + +
Sbjct: 514 QSLYGHMHS-INDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDS 572
Query: 461 KRDRLLLLGSGVGTVRLYDTEA 482
R+L SG G + L D ++
Sbjct: 573 S-GRVLAQASGNGVIHLLDLKS 593
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 53.5 bits (127), Expect = 7e-07
Identities = 58/264 (21%), Positives = 105/264 (39%), Gaps = 44/264 (16%)
Query: 405 GEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDR 464
G H S + V S D IK+W+ + + + + + + DR
Sbjct: 412 GGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYA---LCSFFVPGDR 467
Query: 465 LLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVD 524
+++G+ G ++LYD + L I+ +D + S++ SP+ FV A S+ D
Sbjct: 468 QVVIGTKTGKLQLYDLASGNLLETIDAHDGA--LWSMSLSPDQRGFVTGGADKSVKFW-D 524
Query: 525 FSAPDIGSKGMNQVPGRLLLWDTKTMK-------------------------------QQ 553
F K N RL + T+T++
Sbjct: 525 FELV----KDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT 580
Query: 554 LQF--SLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVE 611
L+F SL + + C +H+G L+ TG+AD ++++ + +C S AH V ++
Sbjct: 581 LKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQ 640
Query: 612 FSYDENTVYSIGEDGKFIQWNIHK 635
F + ++ G+D K QW+ K
Sbjct: 641 FVPKSHLFFTAGKDHKIKQWDADK 664
Score = 36.2 bits (82), Expect = 0.11
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 2/92 (2%)
Query: 542 LLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWR 601
+++WD + + + L AI F NLLVT D +++ +D+ C +
Sbjct: 131 IIVWDV--INESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMV 188
Query: 602 AHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
H EV+ + +E + + D + W+I
Sbjct: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 35.4 bits (80), Expect = 0.19
Identities = 39/173 (22%), Positives = 65/173 (37%), Gaps = 14/173 (8%)
Query: 567 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDG 626
C+ F +V G G ++L+D+ + AH G ++S+ S D+ + G D
Sbjct: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGAD- 517
Query: 627 KFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSA 686
+K ++ L D + +Q+ L S +L S
Sbjct: 518 ---------KSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSL 568
Query: 687 TGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKL 739
+ D L+ LSL GH+ PV+ +D S D T S D +K+
Sbjct: 569 LDCTVKIFYVD--TLKFFLSLYGHKLPVICMDIS--HDGALIATGSADRNVKI 617
Score = 32.0 bits (71), Expect = 2.2
Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 565 INCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE 624
+ C + +G L G DG IR+F + E +++ H + ++++ + S +
Sbjct: 68 VTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSK 127
Query: 625 DGKFIQWN-IHKSGL 638
D I W+ I++SGL
Sbjct: 128 DTDIIVWDVINESGL 142
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.8 bits (125), Expect = 1e-06
Identities = 64/301 (21%), Positives = 111/301 (36%), Gaps = 37/301 (12%)
Query: 353 EKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIM 412
EKKPE A+P P +P P +P L G H ++
Sbjct: 5 EKKPETEAARAQPTPSSSATQSKPT--------------PVKPNYALKFTLAG-HTKAVS 49
Query: 413 HCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGV 472
+ +G +AS D +IK+W K S K + + W++ + LL+ S
Sbjct: 50 SVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDD 108
Query: 473 GTVRLYDTEAKKNL------------CEININDNMPRILSLACSPNGASFVCSAAAPSLT 520
T++++D + K L C N N+ S S +L
Sbjct: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 168
Query: 521 SQVD-FSAPDIGSKGM----NQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGN 575
+ D SA G + G +WDT + Q L+ +D + ++ F+ NG
Sbjct: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS-GQCLKTLIDDDNPPVSFVKFSPNGK 227
Query: 576 LLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD---ENTVYSIGEDGKFIQWN 632
++ D ++L+D + +C ++ H E Y + ++ + S ED WN
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Query: 633 I 633
+
Sbjct: 288 L 288
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.8 bits (125), Expect = 1e-06
Identities = 64/301 (21%), Positives = 111/301 (36%), Gaps = 37/301 (12%)
Query: 353 EKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIM 412
EKKPE A+P P +P P +P L G H ++
Sbjct: 5 EKKPETEAARAQPTPSSSATQSKPT--------------PVKPNYALKFTLAG-HTKAVS 49
Query: 413 HCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGV 472
+ +G +AS D +IK+W K S K + + W++ + LL+ S
Sbjct: 50 SVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDD 108
Query: 473 GTVRLYDTEAKKNL------------CEININDNMPRILSLACSPNGASFVCSAAAPSLT 520
T++++D + K L C N N+ S S +L
Sbjct: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 168
Query: 521 SQVD-FSAPDIGSKGM----NQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGN 575
+ D SA G + G +WDT + Q L+ +D + ++ F+ NG
Sbjct: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS-GQCLKTLIDDDNPPVSFVKFSPNGK 227
Query: 576 LLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD---ENTVYSIGEDGKFIQWN 632
++ D ++L+D + +C ++ H E Y + ++ + S ED WN
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Query: 633 I 633
+
Sbjct: 288 L 288
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/245 (21%), Positives = 95/245 (38%), Gaps = 26/245 (10%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H + I+ + VA+ +D K+W + + ++SL + T DR++
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
Query: 467 LLGSGVGTVRLYDTEAKKNL------------------CEININDNMPRILSLACSPNGA 508
GS TV ++D + + + C + + +M + L + NG
Sbjct: 236 T-GSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGK 294
Query: 509 SFVCSAAAPSLTSQVDFSAPDIGSK--GMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAIN 566
C A ++ S D K G ++ T K + L+ I+
Sbjct: 295 ---CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK--LEGHEGEIS 349
Query: 567 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDG 626
+FN GN L+TG++D R++D Q +C H E++S F+Y N V + +D
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409
Query: 627 KFIQW 631
W
Sbjct: 410 TCRIW 414
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/184 (24%), Positives = 72/184 (39%), Gaps = 29/184 (15%)
Query: 544 LWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAH 603
LW +T K F I C +FN L+ TG+ D +L+D+Q E + R H
Sbjct: 161 LWSVETGKCYHTFRGHTAEIV--CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218
Query: 604 YGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQ 663
E+ S+ F+ + + + D + W+ +G KV+ +L G+
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDA-DTGRKVN------------ILIGHCAEIS 265
Query: 664 VQVPRGRLFAFDSE----GNYMLTC---SATGG--VIYKLGGDEKVLESCLSLGGHRAPV 714
F +D G+ TC AT G V G D+++L+SC G
Sbjct: 266 -----SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Query: 715 VTVD 718
+ D
Sbjct: 321 ASAD 324
Score = 38.9 bits (89), Expect = 0.018
Identities = 47/197 (23%), Positives = 84/197 (42%), Gaps = 28/197 (14%)
Query: 544 LWDTKTMKQQLQFSLDPEPIAINCTAFNHN-GNLLVTGAADGVIRLFDMQQHECAMSWRA 602
LWDT + ++ +L+ + AFN+ G+ + TG+ D +L+ ++ +C ++R
Sbjct: 118 LWDTASGEELN--TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG 175
Query: 603 HYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYK 662
H E+ + F+ V + D W+I ++G +V Y+L + LS
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDI-QNGEEV--YTLRGHSAEIISLS------ 226
Query: 663 QVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTA 722
F++ G+ ++T S V+ D L GH A + + ++
Sbjct: 227 -----------FNTSGDRIITGSFDHTVVV---WDADTGRKVNILIGHCAEISSASFN-- 270
Query: 723 MDCGTCLTASMDGKIKL 739
DC LT SMD KL
Sbjct: 271 WDCSLILTGSMDKTCKL 287
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/201 (26%), Positives = 88/201 (43%), Gaps = 24/201 (11%)
Query: 456 LEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAA 515
L W + LL S TV L+D IN +I+ G S V
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWD---------INAGPKEGKIVDAKAIFTGHSAVVEDV 232
Query: 516 APSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSL-DPEPIAINCTAFN-HN 573
A L + F GS +Q +L++WDT++ L D +NC +FN ++
Sbjct: 233 AWHLLHESLF-----GSVADDQ---KLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
Query: 574 GNLLVTGAADGVIRLFDMQQHECAM-SWRAHYGEVYSVEFS-YDENTVYSIGEDGKFIQW 631
+L TG+AD + L+D++ + + ++ +H E++ V +S ++E + S G D + W
Sbjct: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
Query: 632 NIHKSGLKVSEYSLPSDATGP 652
++ K G E S GP
Sbjct: 345 DLSKIG---EEQSAEDAEDGP 362
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 50.1 bits (118), Expect = 8e-06
Identities = 57/217 (26%), Positives = 90/217 (41%), Gaps = 36/217 (16%)
Query: 557 SLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHE--CAMSW-RAHYGEVYSVEFS 613
++D +NC F+ +GN T +ADG I ++D + E CA+ +AH G +Y++ +S
Sbjct: 44 NIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWS 103
Query: 614 YDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPS-------------DATGPFVLSGYSG 660
D + S D W++ + + VS + + S D LSGY
Sbjct: 104 PDSTHLLSASGDKTSKIWDVSVNSV-VSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYIN 162
Query: 661 YKQVQVPRGRLFAF--DSEGNYMLTCSATGGVIYKLGG---------DEKVLESCLSLG- 708
Y P L S+ LT GG Y G D + E+ G
Sbjct: 163 YLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK 222
Query: 709 GHRAPV--VTVDWSTAMDCGTCLTASMDGKIKLTTLL 743
GH V +TVD + G ++ SMD ++ T+L+
Sbjct: 223 GHTNQVSRMTVD-----ESGQLISCSMDDTVRYTSLM 254
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 49.7 bits (117), Expect = 1e-05
Identities = 76/315 (24%), Positives = 119/315 (37%), Gaps = 53/315 (16%)
Query: 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLL 466
H SS+ D +GRR+ + D ++K+W AT RLL
Sbjct: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIW-----------------------ATDDGRLL 218
Query: 467 LLGSG-VGTVRLYDTEAKKNLCEININDNMPRILSL-ACSPNGASFVCSAAAPSLTSQVD 524
G + + + D M R+ L C+P V + S+TS +
Sbjct: 219 ATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLA---VLQGHSASITS-LQ 274
Query: 525 FSAPDIGSKGMNQVPGR-----LLLWDTKTMK---QQLQFSLDPEP-IAINCTAFNHNGN 575
FS GSK G LWD T+K + +F+ P P + + C++F+ G
Sbjct: 275 FSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGM 334
Query: 576 LLVTGAADGVIRL--FDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
L TG+ D +IR+ F Q E H +V S++FS N S DG W
Sbjct: 335 FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQF 394
Query: 634 HKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTC--------- 684
+ K + + G + +++V + A+D N ++T
Sbjct: 395 KRREWKSILLDMATRPAGQNLQGIEDKITKMKV---TMVAWDRHDNTVITAVNNMTLKVW 451
Query: 685 -SATGGVIYKLGGDE 698
S TG +I+ L G E
Sbjct: 452 NSYTGQLIHVLMGHE 466
Score = 34.7 bits (78), Expect = 0.33
Identities = 24/104 (23%), Positives = 49/104 (47%), Gaps = 3/104 (2%)
Query: 542 LLLWDTKTMKQQLQFSLDP-EPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSW 600
LL T+ Q LQ D + + A++ + N ++T + +++++ +
Sbjct: 403 LLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVL 462
Query: 601 RAHYGEVYSVE-FSYDENTVYSIGEDGKFIQWNIHKSGLKVSEY 643
H EV+ +E +D ++S G DG I W++ + G+K+ Y
Sbjct: 463 MGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLAR-GVKIRSY 505
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/308 (21%), Positives = 116/308 (37%), Gaps = 35/308 (11%)
Query: 383 AGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQ 442
A PE PE P L + G+ ++ R + G + D +K+W NP+
Sbjct: 2 AFPEPKPRPPELPQKRLKTLDCGQ--GAVRAVRFNVDGNYCLTCGSDKTLKLW--NPLRG 57
Query: 443 TKASSISKSPLLSLEWATKRDRLLLL-GSGVGTVRLYDTEAKK----------NLCEINI 491
T + S L+ A D L G G V L+D + + + +
Sbjct: 58 TLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF 117
Query: 492 NDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQ-------VPGRLLL 544
N+ ILS + + + C + P +D + + S ++ V GR+
Sbjct: 118 NEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRR 177
Query: 545 WDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHY 604
+D + + + P I CT F+ +G + + D +RL D E ++ H
Sbjct: 178 YDLRMGQLFSDYVGSP----ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHK 233
Query: 605 GEVYSVE--FSYDENTVYSIGEDGKFIQWNIHKSGLKVS-------EYSLPSDATGPFVL 655
+ Y ++ S + V S EDGK W++ + L ++ SL T P +L
Sbjct: 234 NQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLL 293
Query: 656 SGYSGYKQ 663
+ G Q
Sbjct: 294 TAMGGSVQ 301
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 3/108 (2%)
Query: 518 SLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLL 577
+L +QV FS PD + LWD +T K SL A+ A++ + LL
Sbjct: 81 ALINQVLFS-PDSRIVASASFDKSIKLWDGRTGKYLA--SLRGHVAAVYQIAWSADSRLL 137
Query: 578 VTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGED 625
V+G++D ++++D++ + AM H EVY+V++S D V S G+D
Sbjct: 138 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKD 185
Score = 35.0 bits (79), Expect = 0.25
Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%)
Query: 542 LLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWR 601
L LW K+ L + + IN F+ + ++ + + D I+L+D + + S R
Sbjct: 61 LFLWSPAEDKKPLTRMTGHQAL-INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR 119
Query: 602 AHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
H VY + +S D + S D W++
Sbjct: 120 GHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 151
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 3/108 (2%)
Query: 518 SLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLL 577
+L +QV FS PD + LWD +T K SL A+ A++ + LL
Sbjct: 373 ALINQVLFS-PDSRIVASASFDKSIKLWDGRTGKYLA--SLRGHVAAVYQIAWSADSRLL 429
Query: 578 VTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGED 625
V+G++D ++++D++ + AM H EVY+V++S D V S G+D
Sbjct: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
Score = 35.0 bits (79), Expect = 0.25
Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%)
Query: 542 LLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWR 601
L LW K+ L + + IN F+ + ++ + + D I+L+D + + S R
Sbjct: 353 LFLWSPAEDKKPLTRMTGHQAL-INQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR 411
Query: 602 AHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
H VY + +S D + S D W++
Sbjct: 412 GHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/308 (21%), Positives = 116/308 (37%), Gaps = 35/308 (11%)
Query: 383 AGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQ 442
A PE PE P L + G+ ++ R + G + D +K+W NP+
Sbjct: 2 AFPEPKPRPPELPQKRLKTLDCGQ--GAVRAVRFNVDGNYCLTCGSDKTLKLW--NPLRG 57
Query: 443 TKASSISKSPLLSLEWATKRDRLLLL-GSGVGTVRLYDTEAKK----------NLCEINI 491
T + S L+ A D L G G V L+D + + + +
Sbjct: 58 TLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQF 117
Query: 492 NDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQ-------VPGRLLL 544
N+ ILS + + + C + P +D + + S ++ V GR+
Sbjct: 118 NEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRR 177
Query: 545 WDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHY 604
+D + + + P I CT F+ +G + + D +RL D E ++ H
Sbjct: 178 YDLRMGQLFSDYVGSP----ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHK 233
Query: 605 GEVYSVE--FSYDENTVYSIGEDGKFIQWNIHKSGLKVS-------EYSLPSDATGPFVL 655
+ Y ++ S + V S EDGK W++ + L ++ SL T P +L
Sbjct: 234 NQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLL 293
Query: 656 SGYSGYKQ 663
+ G Q
Sbjct: 294 TAMGGSVQ 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,665,004
Number of Sequences: 37866
Number of extensions: 1520886
Number of successful extensions: 8932
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 213
Number of HSP's that attempted gapping in prelim test: 7822
Number of HSP's gapped (non-prelim): 1193
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.