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Search of human proteins with 114155148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
(247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens] 464 e-131
gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens] 438 e-123
gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens] 420 e-118
gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens] 394 e-110
gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens] 386 e-107
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens] 377 e-105
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 357 7e-99
gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens] 332 1e-91
gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens] 331 3e-91
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 325 3e-89
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 324 4e-89
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens] 323 6e-89
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 307 6e-84
gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens] 303 9e-83
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 296 1e-80
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 295 2e-80
gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens] 259 2e-69
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 79 5e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 75 4e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 75 4e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 9e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 9e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 9e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 9e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 9e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 9e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 9e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 9e-14
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 73 3e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 71 8e-13
>gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
Length = 247
Score = 464 bits (1193), Expect = e-131
Identities = 247/247 (100%), Positives = 247/247 (100%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLHDLCD 247
TLHDLCD
Sbjct: 241 TLHDLCD 247
>gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens]
Length = 247
Score = 438 bits (1127), Expect = e-123
Identities = 232/247 (93%), Positives = 239/247 (96%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLHDLCD 247
TLHDLCD
Sbjct: 241 TLHDLCD 247
>gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens]
Length = 248
Score = 420 bits (1079), Expect = e-118
Identities = 228/245 (93%), Positives = 231/245 (94%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLHDL 245
TL DL
Sbjct: 241 TLLDL 245
>gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens]
Length = 248
Score = 394 bits (1013), Expect = e-110
Identities = 213/245 (86%), Positives = 223/245 (91%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLHDL 245
TL DL
Sbjct: 241 TLLDL 245
>gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens]
Length = 245
Score = 386 bits (991), Expect = e-107
Identities = 202/244 (82%), Positives = 227/244 (93%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG +++EAV+RKI+ LQ+QAD AEERA LQRE++ ER+ RE AEA+VASLNRRIQLVE
Sbjct: 1 MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
+ADRKYEEVARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQ
Sbjct: 121 DADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KED+YEEEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLE++LY QLE+NR L+NELKL
Sbjct: 181 KEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKL 240
Query: 241 TLHD 244
L++
Sbjct: 241 ALNE 244
>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
Length = 248
Score = 377 bits (967), Expect = e-105
Identities = 196/245 (80%), Positives = 223/245 (91%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG+ ++EAVKRKIQ LQQQAD+AE+RA+ LQRE++GER RE+AE +VA+LNRRIQLVE
Sbjct: 1 MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVI+EG+LER EERAE++E KC +LEEELKNVTNNLKSLEA +EKYS+
Sbjct: 121 EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
KEDKYEEEIK+L+DKLKEAETRAEFAER+VAKLEKTIDDLEE+L E N L L
Sbjct: 181 KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ 240
Query: 241 TLHDL 245
TL++L
Sbjct: 241 TLNEL 245
Score = 58.5 bits (140), Expect = 5e-09
Identities = 37/161 (22%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 88 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 147
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 148 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 207
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + L + L N L +
Sbjct: 208 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 248
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 357 bits (915), Expect = 7e-99
Identities = 191/239 (79%), Positives = 210/239 (87%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ A+++K++ + + D E + Q ++E + AEAEVASLNRRIQLVEEELDRA
Sbjct: 44 LAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRA 103
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY
Sbjct: 104 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 163
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE
Sbjct: 164 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 223
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE+ LY+Q + + +S EL L+D+
Sbjct: 224 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDM 282
Score = 62.8 bits (151), Expect = 3e-10
Identities = 37/161 (22%), Positives = 82/161 (50%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E +L+R +ER
Sbjct: 125 ERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERA 184
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
A K E E+ +K +E +A K +K + E ++K +EA+ + E
Sbjct: 185 ELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 244
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ E+ + K + EEL + N++ S+
Sbjct: 245 RSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI 285
>gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]
Length = 284
Score = 332 bits (852), Expect = 1e-91
Identities = 172/238 (72%), Positives = 206/238 (86%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AESKC +LEEELK VTNNLKSLEAQA+KYS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLE+ +Y+Q + + +S EL L+D+
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDI 281
Score = 63.2 bits (152), Expect = 2e-10
Identities = 38/161 (23%), Positives = 82/161 (50%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E ++ + + R++ ++E EL+R++ER
Sbjct: 124 ERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
A K + E+ +K +E +A K K + E ++K + +EA+ + E
Sbjct: 184 EVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ E+ + K + EEL N N++ SL
Sbjct: 244 RSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL 284
Score = 34.3 bits (77), Expect = 0.10
Identities = 18/62 (29%), Positives = 34/62 (54%)
Query: 5 TTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
T + + +I++L+++ +AE RAE +R V + + E EV + + + + EELD
Sbjct: 216 TKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELD 275
Query: 65 RA 66
A
Sbjct: 276 NA 277
>gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]
Length = 284
Score = 331 bits (849), Expect = 3e-91
Identities = 174/237 (73%), Positives = 203/237 (85%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+ LY+Q + + +S EL L+D+
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDM 281
Score = 63.9 bits (154), Expect = 1e-10
Identities = 37/161 (22%), Positives = 82/161 (50%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K E E+ +K +E +A K +K + E ++K +EA+ + E
Sbjct: 184 ELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ E+ + K + EEL + N++ S+
Sbjct: 244 RSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI 284
Score = 29.6 bits (65), Expect = 2.5
Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 9/82 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREV--------EGERRAREQAEAEVASLNRRIQL 58
++ V ++ L+ QA+ ++ +R + E+ E E RA E AE V L + I
Sbjct: 197 LKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRA-EFAERSVTKLEKSIDD 255
Query: 59 VEEELDRAQERLATALQKLEEA 80
+E+EL + + ++L+ A
Sbjct: 256 LEDELYAQKLKYKAISEELDHA 277
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 325 bits (832), Expect = 3e-89
Identities = 171/236 (72%), Positives = 200/236 (84%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
+++K++ + + D E + Q ++E + AE +VA+LNRRIQLVEEELDRAQER
Sbjct: 46 LQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQER 105
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
LATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAEEADRKYEEV
Sbjct: 106 LATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEV 165
Query: 130 ARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
ARKLVI+EG+LER EERAE++E KC +LEEELKNVTNNLKSLEA +EKYS+KEDKYEEEI
Sbjct: 166 ARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEI 225
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
K+L+DKLKEAETRAEFAER+VAKLEKTIDDLEE+L E N L L TL++L
Sbjct: 226 KLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNEL 281
Score = 58.5 bits (140), Expect = 5e-09
Identities = 37/161 (22%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 124 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 184 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + L + L N L +
Sbjct: 244 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 284
Score = 31.6 bits (70), Expect = 0.67
Identities = 27/105 (25%), Positives = 46/105 (43%), Gaps = 14/105 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE------- 60
E V RK+ +L E ER + E E E+ ++ ++ +E
Sbjct: 163 EEVARKLVIL-------EGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYS 215
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKM 105
E+ D+ +E + KL+EAE A+ +ER + +E EEK+
Sbjct: 216 EKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKL 260
Score = 28.1 bits (61), Expect = 7.4
Identities = 14/81 (17%), Positives = 40/81 (49%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++ V ++ L+ ++ E+ ++ + E++ ++AE R + +E+ +D
Sbjct: 197 LKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDL 256
Query: 67 QERLATALQKLEEAEKAADES 87
+E+LA A ++ + D++
Sbjct: 257 EEKLAQAKEENVGLHQTLDQT 277
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 324 bits (831), Expect = 4e-89
Identities = 173/237 (72%), Positives = 199/237 (83%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLEE++ E N + L TL +L
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281
Score = 58.2 bits (139), Expect = 7e-09
Identities = 35/161 (21%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K E E+ +K +E +A K +K + E ++K +EA+ + E
Sbjct: 184 ELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + + + L L ++
Sbjct: 244 RSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
Length = 284
Score = 323 bits (829), Expect = 6e-89
Identities = 174/239 (72%), Positives = 198/239 (82%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLEE++ E N + L TL +L
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281
Score = 58.2 bits (139), Expect = 7e-09
Identities = 35/161 (21%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K E E+ +K +E +A K +K + E ++K +EA+ + E
Sbjct: 184 ELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + + + L L ++
Sbjct: 244 RSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
Length = 284
Score = 307 bits (786), Expect = 6e-84
Identities = 164/238 (68%), Positives = 195/238 (81%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AES+ +LEEEL+ + LKSL A E+YS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLEE L S E N + L TL +L
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLEL 281
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/233 (23%), Positives = 107/233 (45%), Gaps = 35/233 (15%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A+K+K+Q+L+ ++A +RAE QAEA+ R + +EEE
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAE--------------QAEADKKQAEDRCKQLEEEQQAL 46
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
Q++L ++E+ ++ E++ +L++A+ A +A+
Sbjct: 47 QKKLKGTEDEVEKYSESVKEAQE---------------------KLEQAEKKATDAEADV 85
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
+ R++ ++E +L+R +ER A K E E+ +K +E +A K +K + E
Sbjct: 86 ASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQE 145
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
++K ++++ + E R + LE ++ EER R R L EL+
Sbjct: 146 MQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELR 198
>gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]
Length = 284
Score = 303 bits (776), Expect = 9e-83
Identities = 160/237 (67%), Positives = 195/237 (82%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+ LY+Q + + +S EL L+D+
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDM 281
Score = 60.1 bits (144), Expect = 2e-09
Identities = 37/164 (22%), Positives = 90/164 (54%), Gaps = 6/164 (3%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATA---LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+ +++LEE + D++ + + E++ + E++ E +EI++ K +EA+ + E
Sbjct: 184 ELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE-EEIKVLSDK--LKEAETRAE 240
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ E+ + K + EEL + N++ S+
Sbjct: 241 FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM 284
>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
Length = 284
Score = 296 bits (758), Expect = 1e-80
Identities = 159/237 (67%), Positives = 191/237 (80%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLEE++ E N + L TL +L
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281
Score = 54.3 bits (129), Expect = 1e-07
Identities = 35/164 (21%), Positives = 88/164 (53%), Gaps = 6/164 (3%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATA---LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+ +++LEE + D++ + + E++ + E++ E +EI++ K +EA+ + E
Sbjct: 184 ELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE-EEIKVLSDK--LKEAETRAE 240
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + + + L L ++
Sbjct: 241 FAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 295 bits (756), Expect = 2e-80
Identities = 160/239 (66%), Positives = 190/239 (79%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLEE++ E N + L TL +L
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 281
Score = 54.3 bits (129), Expect = 1e-07
Identities = 35/164 (21%), Positives = 88/164 (53%), Gaps = 6/164 (3%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E A+ + + R++ ++E +L+RA+ER
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERA 183
Query: 71 ATA---LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+ +++LEE + D++ + + E++ + E++ E +EI++ K +EA+ + E
Sbjct: 184 ELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE-EEIKVLSDK--LKEAETRAE 240
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + + + L L ++
Sbjct: 241 FAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens]
Length = 231
Score = 259 bits (661), Expect = 2e-69
Identities = 141/239 (58%), Positives = 182/239 (76%), Gaps = 11/239 (4%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A+K+K+Q+L+ ++A +RAE+ + + + +Q E E +L ++++ E+E++
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVE-- 58
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
K E+EKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKY
Sbjct: 59 ---------KYSESEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKY 109
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVI+EG+LER+EERAE+AES+ +LEEEL+ + LKSL A E+YS KEDKYE
Sbjct: 110 EEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYE 169
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDL 245
EEIK+L +KLKEAETRAEFAERSVAKLEKTIDDLEE L S E N + L TL +L
Sbjct: 170 EEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLEL 228
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 78.6 bits (192), Expect = 5e-15
Identities = 55/241 (22%), Positives = 123/241 (51%), Gaps = 22/241 (9%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREV----EGERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + +Q+Q + E+ E+++R+ E E + R Q E + +I+ +EE++
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKIRELEEKM 353
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
QE++ +K +E EK ++ +R + E + + EEK+ QE +++E + + +E +
Sbjct: 354 -HEQEKIREQEEKRQEEEKIREQEKRQEQ--EAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKYS 179
K E K+ E +++ EE+ E K E E++++ ++ ++ Q EK
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 180 QKEDK----------YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLE 229
++E K EE+++ +K++E E + E + + E+ + + EE+++ Q E
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530
Query: 230 R 230
+
Sbjct: 531 K 531
Score = 75.5 bits (184), Expect = 4e-14
Identities = 49/223 (21%), Positives = 106/223 (47%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E ++ + + +Q E+ +R + E E+ R++ EA++ +I+ EE++ +
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 403
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E + +K+ E E+ E E M+ E + + EEK+ QE +++E + E + +
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
E K+ EG + E + + E K EE+++ ++ E + + + + EE
Sbjct: 464 EQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 523
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
++ +K+ E E + + E + + E+ + + E RL Q E+
Sbjct: 524 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 75.5 bits (184), Expect = 4e-14
Identities = 46/212 (21%), Positives = 104/212 (49%), Gaps = 5/212 (2%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQA-----EAEVASLNRRIQLVEEELDRAQERLAT 72
Q++ + EE+ + ++ E E+R ++A E ++ +I+ EE + +E++
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M+ E + + E+K+ QE +++E + + +E + K E K
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Query: 133 LVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKIL 192
+ E ++ EE+ E K E E++++ ++ E ++ +K + EE++
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 535
Query: 193 TDKLKEAETRAEFAERSVAKLEKTIDDLEERL 224
+K++E E + E + + E + EE++
Sbjct: 536 EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 74.7 bits (182), Expect = 7e-14
Identities = 50/226 (22%), Positives = 113/226 (50%), Gaps = 2/226 (0%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL-QREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E ++R+ +++ ++ + E E++ ++E E+ + Q E ++ +R Q E ++ R
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQ 388
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ E E+ E E M E + + EE+M+ QE +++ + E ++K
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
E K+ E ++ EE+ E K E E +++ ++ E + + +K + E
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
E+I+ + ++E E + E + + E+ + + EE++ Q E+ R
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Score = 70.9 bits (172), Expect = 1e-12
Identities = 69/240 (28%), Positives = 122/240 (50%), Gaps = 28/240 (11%)
Query: 7 IEAVKRKIQ----VLQQQADDAEERAERLQREVEGERRAREQAEAEVASL-NRRIQLVEE 61
++ +KRK++ +L QQ AE A+ L +E++ A+ QA+ E L NR Q EE
Sbjct: 232 VKELKRKLERAKLLLPQQQLQAE--ADHLGKELQSVS-AKLQAQVEENELWNRLNQQQEE 288
Query: 62 ELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE---------IQL 112
++ R +E++ +K++E E+ E E M+ E + EEKM QE I+
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 113 KEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAEL--AESKCSELEEELKNVTNNLKS 170
E K +E R+ EE ++ I +R E+ A++ E K E EE+++ +
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE---EM 405
Query: 171 LEAQAEKYSQKEDK-YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLE 229
++ Q EK ++E+K +E+E ++++E E + E + + EK I + EE++ Q E
Sbjct: 406 MQEQEEKMGEQEEKMWEQE-----EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Score = 67.8 bits (164), Expect = 8e-12
Identities = 51/225 (22%), Positives = 112/225 (49%), Gaps = 14/225 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + R+ + +Q++ + +E+ E+++ + E RR E + + R+ +++ E+ +
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK----E 343
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E++ +K+ E EK ++ E+ E ++++EK + QE ++ EE R+ E
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQ---EEEKIREQEKRQEQEAKMWRQ----EEKIREQE 396
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
E R+ E ++ EE+ E K E EEE++ ++ E + + +K + EE
Sbjct: 397 EKIREQ---EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
+I+ + ++E E + E + + E + + EE++ Q E+ R
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498
Score = 67.8 bits (164), Expect = 8e-12
Identities = 51/220 (23%), Positives = 98/220 (44%), Gaps = 10/220 (4%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ K++ ++ + EE+ L+ ++ + + REQ E EEE R QE+
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ----------EEEKIREQEKR 378
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
K+ E+ E E ++ E + EEKM QE ++ E + +E + K
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE 438
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
K+ E + EE+ E E EE++ + EA+ ++ +K + EE+I+
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
K++E E + E + + E+ + + EE++ Q E+
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 538
Score = 60.5 bits (145), Expect = 1e-09
Identities = 41/183 (22%), Positives = 89/183 (48%), Gaps = 7/183 (3%)
Query: 12 RKIQVLQQQADDAEERAERLQREVE--GERRARE-QAEAEVASLNRRIQLVEEELDRAQE 68
R+ + +++Q + E+ E +Q + E GE+ + + E E+ +++ EE++ ++
Sbjct: 387 RQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEK 446
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
++ +K+ E E+ E E M E + + E KM+ QE +++ + E ++K E
Sbjct: 447 KIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE 506
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLK----SLEAQAEKYSQKEDK 184
K+ E ++ EE+ E K E EE+++ ++ + Q + Q+E+K
Sbjct: 507 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Query: 185 YEE 187
+E
Sbjct: 567 MQE 569
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/180 (20%), Positives = 81/180 (45%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 84
EE+ + ++ + ++ E ++ ++ EEE+ +E++ +K+ E EK
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 85 DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE 144
E E ++ E + EEKM QE ++ E + +E + K K+ E + E
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 145 ERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE 204
E+ E E EE++ + E + ++ +K + EE+++ +L++ E + +
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 58.9 bits (141), Expect = 4e-09
Identities = 36/174 (20%), Positives = 85/174 (48%), Gaps = 3/174 (1%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL---QREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
E ++ + +++Q+Q + E+ E++ + E++ + + E ++ ++I+ EE++
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
+E + +K+ E E E E M+ E + + EEK+ QE +++E + E +
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+E K+ E + EE+ + E K EE+++ L+ E + +++
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 57.4 bits (137), Expect = 1e-08
Identities = 57/248 (22%), Positives = 107/248 (43%), Gaps = 28/248 (11%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 67 QERLATALQKLEEA-------EKAADESERGMKV----------IENRAL------KDEE 103
Q + +KLE A + A+ G ++ +E L + EE
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 104 KMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
KM QE +++E + +E + K E K+ E + EE+ E E EE+++
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKIL-TDKLKEAETRAEFAERSVAKLEKTIDDLEE 222
+ + + EK ++E+K +EE KI +K +E E + E + + E+ I + EE
Sbjct: 349 LEEKMH----EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 404
Query: 223 RLYSQLER 230
+ Q E+
Sbjct: 405 MMQEQEEK 412
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 75.5 bits (184), Expect = 4e-14
Identities = 52/223 (23%), Positives = 112/223 (50%), Gaps = 1/223 (0%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
K+ E ++ EE+ + K + EE++ + E + + +K + EE+++
Sbjct: 470 KIQRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLL 234
+K++E E R E + + E + +LEERL ++ LL
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 72.4 bits (176), Expect = 3e-13
Identities = 59/227 (25%), Positives = 109/227 (48%), Gaps = 15/227 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRAREQAEAEVASLNRRIQLVEEE 62
+E+ K +IQ+ + ERA+ L Q +VE +R +E + S + Q+ E E
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE---LQSVSAKLQAQVEENE 286
Query: 63 L-----DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 117
L + +E++ +K++E E+ E E ++ E + + EEKM QE +++E +
Sbjct: 287 LWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQED 346
Query: 118 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEK 177
+ K E K+ E + R EE+ + K E EEE+ ++ Q EK
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE---QEEK 403
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERL 224
+K + E++++ +K++E E E + +LE+ + D EE+L
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450
Score = 70.9 bits (172), Expect = 1e-12
Identities = 53/221 (23%), Positives = 117/221 (52%), Gaps = 10/221 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
+ E+ E+ E E K ELEE +++ L+ +E + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
+ +K++E E + + + + K E+ I + EE+++ Q E+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEK 511
Score = 63.5 bits (153), Expect = 2e-10
Identities = 56/235 (23%), Positives = 114/235 (48%), Gaps = 14/235 (5%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----KSLEAQAEKYS 179
K E ++ E + EE + E K E+EE+++ + + ++ Q EK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
++E+K + K+L +K+ E E + E + + E+ + + EE++ Q E+ R
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Score = 51.2 bits (121), Expect = 8e-07
Identities = 45/199 (22%), Positives = 95/199 (47%), Gaps = 13/199 (6%)
Query: 43 EQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAE------KAADESERGMKVIEN 96
E+ + + A L +++LVE E Q + +KLE A+ + E++R K +++
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 97 RALKDEEKMELQEI-----QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 151
+ K + ++E E+ Q +E K +E K +E K+ E + EE+ E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 152 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVA 211
K E EE+++ + + E + + +K + EE++ +K++E + + + E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 212 KLEKTIDDLEERLYSQLER 230
+ E+ I + EE+ ++ R
Sbjct: 392 RQEEKIREQEEKRQEKMWR 410
Score = 47.0 bits (110), Expect = 2e-05
Identities = 53/222 (23%), Positives = 97/222 (43%), Gaps = 31/222 (13%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
E +L ++ EE+ E K E EE K LK E + + + Q+E +E+E
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQE-- 338
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
+K++E E + E + + E+ I + EE+++ Q E+ R
Sbjct: 339 ---EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR 377
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 75.5 bits (184), Expect = 4e-14
Identities = 52/223 (23%), Positives = 112/223 (50%), Gaps = 1/223 (0%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
K+ E ++ EE+ + K + EE++ + E + + +K + EE+++
Sbjct: 470 KIQRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLL 234
+K++E E R E + + E + +LEERL ++ LL
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 72.4 bits (176), Expect = 3e-13
Identities = 59/227 (25%), Positives = 109/227 (48%), Gaps = 15/227 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRAREQAEAEVASLNRRIQLVEEE 62
+E+ K +IQ+ + ERA+ L Q +VE +R +E + S + Q+ E E
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE---LQSVSAKLQAQVEENE 286
Query: 63 L-----DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 117
L + +E++ +K++E E+ E E ++ E + + EEKM QE +++E +
Sbjct: 287 LWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQED 346
Query: 118 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEK 177
+ K E K+ E + R EE+ + K E EEE+ ++ Q EK
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE---QEEK 403
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERL 224
+K + E++++ +K++E E E + +LE+ + D EE+L
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450
Score = 70.9 bits (172), Expect = 1e-12
Identities = 53/221 (23%), Positives = 117/221 (52%), Gaps = 10/221 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
+ E+ E+ E E K ELEE +++ L+ +E + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
+ +K++E E + + + + K E+ I + EE+++ Q E+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEK 511
Score = 63.5 bits (153), Expect = 2e-10
Identities = 56/235 (23%), Positives = 114/235 (48%), Gaps = 14/235 (5%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----KSLEAQAEKYS 179
K E ++ E + EE + E K E+EE+++ + + ++ Q EK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
++E+K + K+L +K+ E E + E + + E+ + + EE++ Q E+ R
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Score = 51.2 bits (121), Expect = 8e-07
Identities = 45/199 (22%), Positives = 95/199 (47%), Gaps = 13/199 (6%)
Query: 43 EQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAE------KAADESERGMKVIEN 96
E+ + + A L +++LVE E Q + +KLE A+ + E++R K +++
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 97 RALKDEEKMELQEI-----QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 151
+ K + ++E E+ Q +E K +E K +E K+ E + EE+ E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 152 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVA 211
K E EE+++ + + E + + +K + EE++ +K++E + + + E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 212 KLEKTIDDLEERLYSQLER 230
+ E+ I + EE+ ++ R
Sbjct: 392 RQEEKIREQEEKRQEKMWR 410
Score = 47.0 bits (110), Expect = 2e-05
Identities = 53/222 (23%), Positives = 97/222 (43%), Gaps = 31/222 (13%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
E +L ++ EE+ E K E EE K LK E + + + Q+E +E+E
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQE-- 338
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNR 232
+K++E E + E + + E+ I + EE+++ Q E+ R
Sbjct: 339 ---EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR 377
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2219
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2277
Query: 236 NE 237
E
Sbjct: 2278 EE 2279
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2543 QERQRLVASMEEARRRQHE 2561
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1646
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 231 NRL 233
RL
Sbjct: 1787 QRL 1789
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2538
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 239 KL 240
+L
Sbjct: 2599 QL 2600
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1658
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1659 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1767
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1814
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2363 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2418
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2419 ----RTELATQE-KVTL 2430
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1904 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1954
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1574 AEAELQSKR 1582
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1239 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1296 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQ 1372
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2537
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2598 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 967 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1084
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1143
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1144 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1532
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1533 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2177
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2223
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2281
Query: 236 NE 237
E
Sbjct: 2282 EE 2283
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2433
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2434 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2486
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2547 QERQRLVASMEEARRRQHE 2565
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1650
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 231 NRL 233
RL
Sbjct: 1791 QRL 1793
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2542
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Query: 239 KL 240
+L
Sbjct: 2603 QL 2604
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1662
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1663 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1771
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1818
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2247
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2306
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2367 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2422
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2423 ----RTELATQE-KVTL 2434
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1987
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2144
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1790 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1908 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1958
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1403 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1578 AEAELQSKR 1586
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1895 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1952 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2001
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 2002 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1182
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1242
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1243 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1299
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1300 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1357 QQRAEERERLAEVEAALEKQ 1376
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2541
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2542 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2601
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2602 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2639
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2640 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 971 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1088
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1147
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1148 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2219
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2277
Query: 236 NE 237
E
Sbjct: 2278 EE 2279
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2543 QERQRLVASMEEARRRQHE 2561
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1646
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 231 NRL 233
RL
Sbjct: 1787 QRL 1789
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2538
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 239 KL 240
+L
Sbjct: 2599 QL 2600
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1658
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1659 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1767
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1814
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2363 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2418
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2419 ----RTELATQE-KVTL 2430
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1904 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1954
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1574 AEAELQSKR 1582
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1239 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1296 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQ 1372
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2537
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2598 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 967 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1084
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1143
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1144 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1496
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1497 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2141
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2187
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2245
Query: 236 NE 237
E
Sbjct: 2246 EE 2247
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2397
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2398 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2450
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2511 QERQRLVASMEEARRRQHE 2529
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1614
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 231 NRL 233
RL
Sbjct: 1755 QRL 1757
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2506
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Query: 239 KL 240
+L
Sbjct: 2567 QL 2568
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1626
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1627 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1735
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1782
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2211
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2270
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2331 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2386
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2387 ----RTELATQE-KVTL 2398
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1951
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2108
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1754 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1872 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1922
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1367 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1542 AEAELQSKR 1550
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1859 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1916 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1965
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 1966 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1146
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1206
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1207 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1264 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1321 QQRAEERERLAEVEAALEKQ 1340
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2505
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2506 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2565
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2566 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2603
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2604 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 935 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 994 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1052
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1111
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1112 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1665
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1666 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2310
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2356
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2414
Query: 236 NE 237
E
Sbjct: 2415 EE 2416
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2566
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2567 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2619
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2680 QERQRLVASMEEARRRQHE 2698
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1783
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 231 NRL 233
RL
Sbjct: 1924 QRL 1926
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2675
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Query: 239 KL 240
+L
Sbjct: 2736 QL 2737
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1795
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1796 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1904
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1951
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2380
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2439
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2500 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2555
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2556 ----RTELATQE-KVTL 2567
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 2120
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2277
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1923 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 2041 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 2091
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1536 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1711 AEAELQSKR 1719
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 2028 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 2085 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2134
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 2135 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1315
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1375
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1376 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1433 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1490 QQRAEERERLAEVEAALEKQ 1509
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2674
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2675 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2734
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2735 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2772
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2773 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 1104 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1221
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1280
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1281 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1506
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1507 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2094
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2151
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2197
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2255
Query: 236 NE 237
E
Sbjct: 2256 EE 2257
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2407
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2408 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2521 QERQRLVASMEEARRRQHE 2539
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1624
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 231 NRL 233
RL
Sbjct: 1765 QRL 1767
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2516
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Query: 239 KL 240
+L
Sbjct: 2577 QL 2578
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1636
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1637 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1745
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1792
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2221
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2280
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2341 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2396
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2397 ----RTELATQE-KVTL 2408
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1961
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2118
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1764 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1882 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1932
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1377 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1552 AEAELQSKR 1560
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1869 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1925
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1926 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1975
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 1976 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2031
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1156
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1216
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1217 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1273
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1274 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1330
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1331 QQRAEERERLAEVEAALEKQ 1350
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2515
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2516 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2575
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2576 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2613
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2614 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 945 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1062
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1121
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1122 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1514
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1515 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2102
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2159
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2205
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2263
Query: 236 NE 237
E
Sbjct: 2264 EE 2265
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2415
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2416 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2468
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2529 QERQRLVASMEEARRRQHE 2547
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1632
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 231 NRL 233
RL
Sbjct: 1773 QRL 1775
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2524
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Query: 239 KL 240
+L
Sbjct: 2585 QL 2586
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1644
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1645 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1753
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1800
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2229
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2288
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2349 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2404
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2405 ----RTELATQE-KVTL 2416
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1969
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2126
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1772 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1890 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1940
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1384
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1385 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1560 AEAELQSKR 1568
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1877 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1933
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1934 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1983
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 1984 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2039
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1106 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1164
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1224
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1225 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1281
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1282 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1339 QQRAEERERLAEVEAALEKQ 1358
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2523
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2524 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2583
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2584 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2621
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2622 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 953 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1070
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1129
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1130 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1173
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 74.3 bits (181), Expect = 9e-14
Identities = 65/230 (28%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1555
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1556 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
AE+ +Q++ + E K + +EA R + E++V + E +LE++
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Score = 67.0 bits (162), Expect = 1e-11
Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 32/242 (13%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2143
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2200
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
AE+ R+ +V ++L + LE T+ + L L+EEL+ L+A+A +
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNL-------LDEELQR-------LKAEATEA 2246
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
+++ + EEE +++ ++L + + R E R++ +K D+ + L + E+ + ++
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVA 2304
Query: 236 NE 237
E
Sbjct: 2305 EE 2306
Score = 62.8 bits (151), Expect = 3e-10
Identities = 62/259 (23%), Positives = 123/259 (47%), Gaps = 35/259 (13%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2456
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSEL----EE 159
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K E+ +E
Sbjct: 2457 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEMQTVQQE 2509
Query: 160 ELKNVTNNL-KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID 218
+L T L +S ++ + Q+E E+E L ++ +A+ + ++ ++
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 219 DLEERLYSQLERNRLLSNE 237
+RL + +E R +E
Sbjct: 2570 QERQRLVASMEEARRRQHE 2588
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 16/240 (6%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNE-LKLTL 242
+EE + +EAE RA+ A+ E+ ++ E +LER +L +NE L+L L
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQ----QQAEAERAREEAER----ELERWQLKANEALRLRL 1673
Score = 62.0 bits (149), Expect = 5e-10
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL + + E
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLK--EAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q + ++ + + E T K + EAE AE V K + E R S+ +
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 231 NRL 233
RL
Sbjct: 1814 QRL 1816
Score = 58.5 bits (140), Expect = 5e-09
Identities = 59/242 (24%), Positives = 116/242 (47%), Gaps = 33/242 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
+ + + ++ IE + + E+ + +K +L EE +++
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-----------------QQRQQ 2565
Query: 183 DKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ----LERNRLLSNEL 238
+ E+E + L ++EA R AE V + ++ + LE++ Q E N+ L +L
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 239 KL 240
+L
Sbjct: 2626 QL 2627
Score = 57.0 bits (136), Expect = 1e-08
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 18 QQQAD------DAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
QQQA+ +AE ER Q + R R QAE EVA Q+ LA
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQ---------------QKSLA 1685
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
A EAEK +E+ER + + + EL E +L++ + +AE ++ +
Sbjct: 1686 QA-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
+L+ + + E+ E++ +L E + + L+ E T + LEA+ K + E E+ +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-L 1794
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
L K + E +E+S +LE E L + R R L+ E K
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRE-LAEEAARLRALAEEAK 1841
Score = 55.1 bits (131), Expect = 6e-08
Identities = 55/257 (21%), Positives = 119/257 (46%), Gaps = 35/257 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2270
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2329
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ E+L+
Sbjct: 2390 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2445
Query: 226 SQLERNRLLSNELKLTL 242
R L + E K+TL
Sbjct: 2446 ----RTELATQE-KVTL 2457
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 2010
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2167
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/231 (21%), Positives = 96/231 (41%), Gaps = 9/231 (3%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ---------LKEAKHIAEEADRKYEE 128
+EA + ++E + + E + LQ+ Q + A+ AEEA+ +
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
R+ +E E + AE + + K E +A + +Q E +
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELK 239
+ ++++ + AE R A++E+ + L +L + LL EL+
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Score = 51.2 bits (121), Expect = 8e-07
Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 24/236 (10%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAE------------- 120
++ +A E+ R ++ E RAL +E K + Q + A+ AE
Sbjct: 1813 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EA R E L E + ER AE + LEE+ +++ AQ K S
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
E E + ++ D L++ E A EK E +LE R+ SN
Sbjct: 1931 SE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSN 1981
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/249 (21%), Positives = 115/249 (46%), Gaps = 28/249 (11%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1426 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAK-LEKTIDDLEER 223
L S EA+A + Q+ + EE+++ + +EAE R AE A+ ++ ++ +
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 224 LYSQLERNR 232
++L+ R
Sbjct: 1601 AEAELQSKR 1609
Score = 43.5 bits (101), Expect = 2e-04
Identities = 51/222 (22%), Positives = 93/222 (41%), Gaps = 33/222 (14%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1918 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1974
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1975 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2024
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTN-----NLKSLEAQAEK 177
EE AR+ ++ER + + E A E+E K L+A+ +
Sbjct: 2025 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2080
Query: 178 YS----QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
++ QKE + ++ ++ L + AE A R+ + E+
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Score = 42.7 bits (99), Expect = 3e-04
Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 41/260 (15%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1205
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------ESERGMKVIENRAL 99
VA L R Q V + D Q L ++L ++AD ++ R + I+ L
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1265
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEV------ARKLV--IIEGDLERTEERAEL-- 149
D + + QL++ + + EE +R E+V A++ + I + +L+ +A+L
Sbjct: 1266 ADSQAV---REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
Query: 150 --AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ +K +++ ++V L YS+ + IK +++ L+ E AE
Sbjct: 1323 VASPAKKPKVQSGSESVIQEYVDLRTH---YSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 208 RSVAKLEKTIDDLEERLYSQ 227
+ A+ + + ++E L Q
Sbjct: 1380 QQRAEERERLAEVEAALEKQ 1399
Score = 39.3 bits (90), Expect = 0.003
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 40/230 (17%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2564
Query: 67 QERLATALQKL----EEAEKAADESERGMK-------VIENRALKDEEKMELQEIQLKEA 115
Q+++ Q+L EEA + E+E G++ +E + + EE + + +L+E
Sbjct: 2565 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2624
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEA 173
+ EE + RA LA S+ + K + N +L+
Sbjct: 2625 LQLLEE----------------------QHRAALAHSEEVTASQVAATKTLPNGRDALDG 2662
Query: 174 QAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
A + + K+ +L+EA + + +A+ T+D+L R
Sbjct: 2663 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712
Score = 35.4 bits (80), Expect = 0.046
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 15 QVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNR-RIQLVEEELDRAQERLAT 72
Q+LQ A+E + R QR + + R Q EA E +++R R+ L +E +R+A
Sbjct: 994 QLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052
Query: 73 ALQKLEEAE-------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
+ E E + + E+E+ + + E + EL E+ L + + + +
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL-ELTLGKLEQVRSLSAIY 1111
Query: 126 YEEVARKLVIIEGD------LERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E++ ++I G L EE+ + A++ + L E L+ +LK L AQAE
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQ 1170
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
D L D+L+ A+ E ++ + + ++ ER+ LER
Sbjct: 1171 PTFDA-------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 72.8 bits (177), Expect = 3e-13
Identities = 54/216 (25%), Positives = 114/216 (52%), Gaps = 24/216 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
EA ++ ++LQ++ + + LQ+ +EG+ R EQA A S+ ++L EEE R +
Sbjct: 369 EAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---SMQAEMELKEEEAARQR 425
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+R+ ++LEE ++ E+ + +E +A +DEE + + + +L E + E
Sbjct: 426 QRI----KELEEMQQRLQEALQ----LEVKARRDEESVRIAQTRLLEEE----------E 467
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
E ++L+ ++ + ER ERA+ + EL++E+ + +L+ + Q E+ Q + +E
Sbjct: 468 EKLKQLMQLKEEQERYIERAQQEKE---ELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEER 223
+++ KL++A T + + +L I+ ++R
Sbjct: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKR 560
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/232 (20%), Positives = 95/232 (40%), Gaps = 27/232 (11%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
VK + + A D +R E + R QAE + + Q E+ ++ + R
Sbjct: 283 VKTANRTYEMSASDTRQRQEWTAAI---QMAIRLQAEGKTSLHKDLKQKRREQREQRERR 339
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
A ++L ++ +E ER ++ +E LQE Q + + + EE +R+ +
Sbjct: 340 RAAKEEELLRLQQLQEEKERKLQELEL----------LQEAQRQAERLLQEEEERRRSQH 389
Query: 130 ARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ------KED 183
+EG L E+ +++ EEE +K LE ++ + K
Sbjct: 390 RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKAR 449
Query: 184 KYEEEIKIL--------TDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQ 227
+ EE ++I +KLK+ E ER + + ++ ++L++ + Q
Sbjct: 450 RDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQ 501
Score = 30.8 bits (68), Expect = 1.1
Identities = 15/62 (24%), Positives = 29/62 (46%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R +Q QQQ ++ + +R +VE +R QA V N ++ + ++ +R
Sbjct: 503 RSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPV 562
Query: 72 TA 73
T+
Sbjct: 563 TS 564
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 71.2 bits (173), Expect = 8e-13
Identities = 50/223 (22%), Positives = 106/223 (47%), Gaps = 3/223 (1%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREV-EGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E + R+ + + +Q EE + Q E+ E + REQ E + +I EE++ +
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE--IWRQKEKIHEQEEKIRKQ 555
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ + E+ E E + E + + EEK+ QE +++E + + +E + K
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
E K+ E ++ EE+ E K E E++++ ++ E ++ +K + E
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLE 229
E++ +K++E E + E + + E + EE++ E
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 66.2 bits (160), Expect = 2e-11
Identities = 56/251 (22%), Positives = 116/251 (46%), Gaps = 21/251 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRARE---QAEAEVASLNRRIQLVEEELD 64
E ++R+ +++ ++ + + E + + E RR E + E ++ L ++ E+E
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH--EQEKI 453
Query: 65 RAQERLATALQKLEEAEKAADE------SERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
R QE +K+ E EK ++ E ++ E + + EEKM QE ++ E + I
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 119 AEEADR-------KYEEVARKLVII---EGDLERTEERAELAESKCSELEEELKNVTNNL 168
EE R + EE R+ I + + EE+ E K EE++ + +
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 169 KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQL 228
+ E + + +K + EE+I+ +K++E E + E + + E+ + + EE++ Q
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 229 ERNRLLSNELK 239
E+ R +++
Sbjct: 634 EKMRRQEEKIR 644
Score = 65.9 bits (159), Expect = 3e-11
Identities = 55/257 (21%), Positives = 120/257 (46%), Gaps = 17/257 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLV---EEELD 64
E ++ + +Q+Q + E+ E+++ + E RR E + + R+ +++ EE++
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 427
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRA----LKDEEKMELQEIQLKEAKHIAE 120
R +E + +K+ E E+ E E+ + E R ++++EK + QE ++ +
Sbjct: 428 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 487
Query: 121 EADRKYEEVARKL-----VIIEGDLERTEERAELAESKCSELEE--ELKNVTNNLKSLEA 173
E + K E K+ I E + R EE+ + E + E+ E + + + +
Sbjct: 488 EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE 547
Query: 174 QAEKYSQKEDKY---EEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLER 230
Q EK ++E+K EE++ +K++E E + E + + E+ I + EE++ Q E
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEM 607
Query: 231 NRLLSNELKLTLHDLCD 247
+ ++ +C+
Sbjct: 608 TQEQEEKMGEQEEKMCE 624
Score = 64.7 bits (156), Expect = 7e-11
Identities = 47/201 (23%), Positives = 99/201 (49%), Gaps = 16/201 (7%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQA---EAEVASLNRRIQLVEEELDRAQE 68
R+ + + +Q + E+ E+++++ E R E+ E ++ ++ EE++ +E
Sbjct: 533 REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
++ +K+ E E+ E E M E + + EEKM+ QE +++ + E ++K E
Sbjct: 593 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDK-YEE 187
K+ E ++ EE+ E K E EE+ ++ Q EK ++E+K +E+
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK----------MQEQEEKMRRQEEKMWEQ 702
Query: 188 EIKI--LTDKLKEAETRAEFA 206
E+++ +K++E + E A
Sbjct: 703 EVRLRQQEEKMQEHQEHLEAA 723
Score = 64.3 bits (155), Expect = 9e-11
Identities = 53/237 (22%), Positives = 110/237 (46%), Gaps = 7/237 (2%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRARE----QAEAEVASLNRRIQLVEEELDRA 66
+ KI+ +++ + EE+ R + ++ + + RE Q + E+ +I+ +EE+ R
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR-EQEEIWRQ 541
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ + E+ E M E + + EEK+ QE +++E + E + K
Sbjct: 542 KEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
E E + EE+ E K E EE+++ ++ E + + +K + E
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 661
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLH 243
E ++ +K+ E E + E + + E+ + EE+++ Q RL E K+ H
Sbjct: 662 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ--EVRLRQQEEKMQEH 716
Score = 61.2 bits (147), Expect = 8e-10
Identities = 63/245 (25%), Positives = 118/245 (48%), Gaps = 26/245 (10%)
Query: 7 IEAVKRKI---------QVLQQQAD----DAEERAERLQREVEGER---RAREQAEAEVA 50
++ +KRK+ Q LQ +AD + + + +LQ +VE R +Q E ++
Sbjct: 305 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 364
Query: 51 SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI 110
+IQ EE++ +E++ +K+ E E+ E M E + + EE M +E
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424
Query: 111 QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELE---EELKNVTNN 167
+++ + + E + K E+ K+ E E+ E+R E E K E E E+ +
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--EEKIREQEKRQEQEAKMWRQ 482
Query: 168 LKSLEAQAEKYSQKEDK-YEEEIKI-LTDKLKEAETRAEFAERSVAKLEKTIDDLEERLY 225
+ + Q EK ++E+K + +E KI +K++E E R E + + + E+ I + EE ++
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQEEKIREQEE-IW 539
Query: 226 SQLER 230
Q E+
Sbjct: 540 RQKEK 544
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/187 (22%), Positives = 88/187 (47%), Gaps = 5/187 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E + R+ + + +Q + ++ E++ R+ E E + REQ E +V +I+ EE++
Sbjct: 536 EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE-KVWRQEEKIREQEEKI 594
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ + +E E+ E E M E + + EEKM QE +++E + E +
Sbjct: 595 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE 654
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKED 183
K E + E + EE+ E K E EE+++ + E + + +K
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Query: 184 KYEEEIK 190
+++E ++
Sbjct: 715 EHQEHLE 721
Score = 53.5 bits (127), Expect = 2e-07
Identities = 60/265 (22%), Positives = 108/265 (40%), Gaps = 41/265 (15%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 242 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 301
Query: 67 QERLATALQKLEEA-------EKAADESERGMKV----------IENRAL------KDEE 103
Q + +KLE A + A+ G ++ +E L + EE
Sbjct: 302 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 361
Query: 104 KMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEE---- 159
KM QE +++E + +E + K E K+ E + R EE E K EE
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 160 -------------ELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKIL-TDKLKEAETRAEF 205
E + L+ + EK ++E+K +EE KI +K +E E +
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 206 AERSVAKLEKTIDDLEERLYSQLER 230
E + + E+ I + EE+++ Q E+
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEK 506
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/167 (23%), Positives = 80/167 (47%), Gaps = 5/167 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E + R+ + + Q + E+ E++ R+ E E + REQ E ++ Q EE++
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE-KIREQEEMTQEQEEKM 615
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K++E E+ E ++ E + + EEK+ QE ++E + E +
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS 170
K E K+ E + R EE+ E + + EE+++ +L++
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 50.8 bits (120), Expect = 1e-06
Identities = 35/146 (23%), Positives = 72/146 (49%), Gaps = 3/146 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRARE---QAEAEVASLNRRIQLVEEELD 64
E V R+ + +++Q + E+ E+++ + E + E + E ++ ++Q EE++
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
R +E++ +K+ E E+ E E M+ E + + EEKM QE +++E + +
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697
Query: 125 KYEEVARKLVIIEGDLERTEERAELA 150
K E +L E ++ +E E A
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLEAA 723
Score = 46.2 bits (108), Expect = 3e-05
Identities = 47/212 (22%), Positives = 93/212 (43%), Gaps = 19/212 (8%)
Query: 43 EQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE 102
EQA + VA+ ++ EEL + ER A +L+ + E+ K+ E L +
Sbjct: 239 EQALSAVATQKKKADRYIEELTK--ERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 296
Query: 103 EKMELQEIQLKEAKHIAEEA---------DRKYEEVARKLVIIEGDLERTEERAEL---- 149
EK E+Q + +KE K E A + + + ++L + L+ E EL
Sbjct: 297 EKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 355
Query: 150 ---AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFA 206
E K EE+++ ++ E + + +K + EE+++ + + E E +
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 415
Query: 207 ERSVAKLEKTIDDLEERLYSQLERNRLLSNEL 238
E + + E+ + EE ++ + E+ R L ++
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.303
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,323,282
Number of Sequences: 37866
Number of extensions: 331360
Number of successful extensions: 14121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 848
Number of HSP's successfully gapped in prelim test: 924
Number of HSP's that attempted gapping in prelim test: 2920
Number of HSP's gapped (non-prelim): 6358
length of query: 247
length of database: 18,247,518
effective HSP length: 100
effective length of query: 147
effective length of database: 14,460,918
effective search space: 2125754946
effective search space used: 2125754946
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.