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Search of human proteins with 22027528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027528 PAK-interacting exchange factor beta isoform b
[Homo sapiens]
(782 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 1580 0.0
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 1568 0.0
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 1506 0.0
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 1125 0.0
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 1125 0.0
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 828 0.0
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 136 9e-32
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 135 1e-31
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 124 4e-28
gi|71274148 pleckstrin homology domain containing, family G (wit... 117 5e-26
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 109 9e-24
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 106 9e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 106 9e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 103 8e-22
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 96 2e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 96 2e-19
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 87 8e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 86 2e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 79 1e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 79 2e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 79 2e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 78 3e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 78 3e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 78 3e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 78 3e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 78 3e-14
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 78 4e-14
gi|39930351 dynamin binding protein [Homo sapiens] 74 4e-13
gi|55749621 pleckstrin homology domain containing, family G, mem... 73 9e-13
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 1580 bits (4092), Expect = 0.0
Identities = 782/782 (100%), Positives = 782/782 (100%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS
Sbjct: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
Query: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED
Sbjct: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
Query: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG
Sbjct: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
Query: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE
Sbjct: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
Query: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE
Sbjct: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
Query: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF
Sbjct: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
Query: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL
Sbjct: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
Query: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN
Sbjct: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
Query: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH
Sbjct: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
Query: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 660
TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK
Sbjct: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 660
Query: 661 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 720
KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH
Sbjct: 661 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 720
Query: 721 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 780
NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH
Sbjct: 721 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 780
Query: 781 QN 782
QN
Sbjct: 781 QN 782
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 1568 bits (4060), Expect = 0.0
Identities = 782/803 (97%), Positives = 782/803 (97%), Gaps = 21/803 (2%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
Query: 61 RSESECLSNIREFLRGCGASLRLE---------------------TFDANDLYQGQNFNK 99
RSESECLSNIREFLRGCGASLRLE TFDANDLYQGQNFNK
Sbjct: 61 RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK 120
Query: 100 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 159
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
Sbjct: 121 VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT 180
Query: 160 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 219
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
Sbjct: 181 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240
Query: 220 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 279
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
Sbjct: 241 VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP 300
Query: 280 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 339
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
Sbjct: 301 LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL 360
Query: 340 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 399
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
Sbjct: 361 YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL 420
Query: 400 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 459
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
Sbjct: 421 ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV 480
Query: 460 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 519
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
Sbjct: 481 TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE 540
Query: 520 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 579
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
Sbjct: 541 NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 600
Query: 580 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 639
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
Sbjct: 601 PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP 660
Query: 640 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 699
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
Sbjct: 661 LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY 720
Query: 700 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 759
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
Sbjct: 721 CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW 780
Query: 760 TAHSYRMGSTSRKSCCSYISHQN 782
TAHSYRMGSTSRKSCCSYISHQN
Sbjct: 781 TAHSYRMGSTSRKSCCSYISHQN 803
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 1506 bits (3900), Expect = 0.0
Identities = 753/782 (96%), Positives = 753/782 (96%), Gaps = 29/782 (3%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK
Sbjct: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEK----- 55
Query: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS
Sbjct: 56 ------------------------TFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 91
Query: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED
Sbjct: 92 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 151
Query: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG
Sbjct: 152 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 211
Query: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE
Sbjct: 212 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 271
Query: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE
Sbjct: 272 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 331
Query: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF
Sbjct: 332 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 391
Query: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL
Sbjct: 392 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 451
Query: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN
Sbjct: 452 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 511
Query: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH
Sbjct: 512 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 571
Query: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 660
TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK
Sbjct: 572 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMK 631
Query: 661 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 720
KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH
Sbjct: 632 KLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMH 691
Query: 721 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 780
NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH
Sbjct: 692 NHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISH 751
Query: 781 QN 782
QN
Sbjct: 752 QN 753
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 158 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 217
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 218 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 277
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 278 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 337
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 338 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 397
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 398 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 457
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 458 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 517
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 518 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 577
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 578 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 637
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 638 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 697
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 698 AYCTSAKTRQTLNST 712
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 158 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 217
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 218 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 277
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 278 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 337
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 338 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 397
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 398 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 457
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 458 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 517
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 518 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 577
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 578 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 637
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 638 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 697
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 698 AYCTSAKTRQTLNST 712
AYCTSAKTRQTLNS+
Sbjct: 541 AYCTSAKTRQTLNSS 555
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 828 bits (2138), Expect = 0.0
Identities = 422/714 (59%), Positives = 534/714 (74%), Gaps = 47/714 (6%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP 60
MN EQ VTWLI+LGVLESPKKTI DPE FL++SLK+GVVLC+L+ RL+PG++EK +P
Sbjct: 1 MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP 60
Query: 61 RSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDS 120
++E++C++NI +FL+GC A+L++E FD +DLY G NF+KVLS+L+ +NK T D S+
Sbjct: 61 QTEADCINNINDFLKGC-ATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATED--QLSER 117
Query: 121 VCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNED 180
C R SS + Q + T Q Q ++++MT+N ++QL+V+A+FNF+QTNED
Sbjct: 118 PCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNED 177
Query: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKG 240
ELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYVRE+K+SE+P+SPK+ KG
Sbjct: 178 ELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKA------VKG 231
Query: 241 FDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEE 300
F+T + K+YY VVLQNIL+TE EY+KELQ++L TYLRPLQ++ LS+ ++ L+GN EE
Sbjct: 232 FETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEE 291
Query: 301 ICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE 360
+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K++YL YCANHPSAVNVLT+HS+E
Sbjct: 292 VCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
Query: 361 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAF 420
L +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+ELERHMED H D QDI K++ AF
Sbjct: 352 LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAF 411
Query: 421 KNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
K L QCQ++RKRK+LELQIL+E I+ WEG+DIK LGNV +MSQV++Q EEK ERYL
Sbjct: 412 KTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYL 471
Query: 481 LLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++ E + FEI+G+ +ERI+V CN
Sbjct: 472 MLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCN 531
Query: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYH 600
N QD QEW+E L + + P+S + SK + + + H
Sbjct: 532 NNQDFQEWLEQLNRLIR------------------------GPASCSSLSKTSSSSCSAH 567
Query: 601 TLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKE-------DLS 653
+ S G P GPLEPP+ KPWSLSCLRPAPPLRPSAAL YKE + S
Sbjct: 568 S--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESS 620
Query: 654 KSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQ 707
KSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDAQILKVIEAYCTSA +Q
Sbjct: 621 KSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQ 674
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 136 bits (342), Expect = 9e-32
Identities = 128/542 (23%), Positives = 230/542 (42%), Gaps = 29/542 (5%)
Query: 120 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 179
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 180 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 236
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 237 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 295
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 296 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 351
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 352 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 411
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 412 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 469
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 470 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 521
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 522 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 580
+NAF + G+ + L+ + Q W++ ++ + + T S+
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET--GFSITELQRKQAM 627
Query: 581 VTPSSKHADSKPAPL-TPAYHTLPHPSHHGTPHTTINWGPL---EPPKTPKPWSLSCLRP 636
+ S + KP + P Y L H P L EP + P + S R
Sbjct: 628 LNASKQQVTGKPKAVGRPCY--LTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRL 685
Query: 637 AP 638
AP
Sbjct: 686 AP 687
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 135 bits (341), Expect = 1e-31
Identities = 111/465 (23%), Positives = 207/465 (44%), Gaps = 21/465 (4%)
Query: 120 SVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNE 179
+VCA +D L S S H + G+ +++ + + + A ++ ++
Sbjct: 152 AVCADEVGSEEDLYDDLHSSS-HHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDD 210
Query: 180 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTLKS 236
EL F GDVI V WW G + GWFP+++VR ++P +P +G +
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGA 270
Query: 237 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISYLM 295
G + + V+ IL TE +Y K L+ + Y+R + ++ S + +
Sbjct: 271 EDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIF 330
Query: 296 GNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA---V 351
GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A +
Sbjct: 331 GNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACVEL 389
Query: 352 NVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQ 411
+ LT+ S+ + F + + L L P ++ KYP L EL ++ H D +
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFK 449
Query: 412 DIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQC 469
D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L +
Sbjct: 450 DVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRV 509
Query: 470 AGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH------ 521
+ K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 510 TQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569
Query: 522 RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 565
+NAF + G+ + L+ + Q W++ ++ + + T
Sbjct: 570 KNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 124 bits (310), Expect = 4e-28
Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)
Query: 151 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 210
G+ +++ + N + A ++ ++ EL F GDVI V WW G +
Sbjct: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
Query: 211 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 263
WFP+++VR ++ +++ +S S + S + + + NK V++ I++TE
Sbjct: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
Query: 264 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 322
Y K L+ + Y+R + + + A ++ + GN+E+I FQ+ ++ LE+ E
Sbjct: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
Query: 323 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 379
+G CFL +Y YC NHP A L ++ F E I +
Sbjct: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
Query: 380 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 438
G L P ++ KYP L EL ++ H D +I+ + A KN++ E RKRK +
Sbjct: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
Query: 439 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 494
+ +I WEG DI + S L + + +R LF + L+
Sbjct: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
Query: 495 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 547
R Y+G+L M + L D + +NAF++ + + + C Q+D
Sbjct: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
Query: 548 WVE 550
W++
Sbjct: 552 WLQ 554
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 117 bits (292), Expect = 5e-26
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 250 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 307
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Query: 308 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 365
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
Query: 366 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 425
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
Query: 426 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 483
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
Query: 484 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 542
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
Query: 543 QDLQEWVEHLQK 554
QD + WV HL++
Sbjct: 402 QDKRLWVLHLKR 413
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 109 bits (273), Expect = 9e-24
Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)
Query: 181 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 235
EL+F GDVI V WW G ++ GWFP+++VR E + E P ++G L
Sbjct: 26 ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
Query: 236 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 288
D + + N V+ I+ TE Y K L+ + YL+ + + S
Sbjct: 85 --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
Query: 289 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 347
+ + GN+E+I FQ V+ LE+ + +G CFL +Y YC NH
Sbjct: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
Query: 348 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 404
A L++ F E I + G L P ++ KYP L EL ++
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
Query: 405 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 461
H+D + + ++A +N++ Q E ++R E ++ ++ +WEG+DI + Y
Sbjct: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
Query: 462 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 520
++ +R LF + +++ R Y+G++ + +ED +
Sbjct: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
Query: 521 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 558
+NAF++ E I L ++ W+ +++ K+
Sbjct: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 106 bits (264), Expect = 9e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 227
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
Query: 228 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 287
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
Query: 288 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 344
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
Query: 345 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 400
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
Query: 401 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 435
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 169 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 224
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 225 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 258
K VSPK L S P + A Y NV N+
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 170 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 229
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
Query: 230 KSGTLKSPPK 239
KSG P+
Sbjct: 1020 KSGASNKKPE 1029
Score = 47.4 bits (111), Expect = 5e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 166 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 224
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 106 bits (264), Expect = 9e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 227
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
Query: 228 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 287
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
Query: 288 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 344
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
Query: 345 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 400
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
Query: 401 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 435
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 169 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 224
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 225 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 258
K VSPK L S P + A Y NV N+
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 170 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 229
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
Query: 230 KSGTLKSPPK 239
KSG P+
Sbjct: 1047 KSGASNKKPE 1056
Score = 47.4 bits (111), Expect = 5e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 166 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 224
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 103 bits (256), Expect = 8e-22
Identities = 66/271 (24%), Positives = 131/271 (48%), Gaps = 13/271 (4%)
Query: 172 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 231
+++ N+DEL+F+KG +I+V E+ WW+G +NG+ G FPSNYV+ + P
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK-LTTDMDPSQQWC 1222
Query: 232 GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI 291
L T + Y + ++ TE Y +LQ V + +PL SE L+ +
Sbjct: 1223 SDLHLLDMLTPTERKRQGY----IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEV 1278
Query: 292 SYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYCANHP 348
+ + N +E+ L+++L K+ + + +G +P M+ Y+ +C+
Sbjct: 1279 AMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQL 1337
Query: 349 SAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELERHME 404
+ ++ + ++E +F E + A P + L++ + KP R+ +YP ++K + +
Sbjct: 1338 NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP 1397
Query: 405 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 435
+ H D ++ ++ + L +Q E + KE
Sbjct: 1398 ENHPDHSHLKHALEKAEELCSQVNEGVREKE 1428
Score = 58.2 bits (139), Expect = 3e-08
Identities = 26/70 (37%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 170 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 229
A + ++ + + +L+F +GDVI VT+ ++G WW GT+ + G FPSNYVR + +
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 230 KSGTLKSPPK 239
K+G+L P+
Sbjct: 1068 KTGSLGKKPE 1077
Score = 55.1 bits (131), Expect = 3e-07
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 9/78 (11%)
Query: 169 RAKFNFQQTNEDELSFSKGDVIHV-------TRVEEGGWWEGTLNGRTGWFPSNYVREVK 221
RA + F+ + DE++ GD++ V ++ E GW G L G+TGWFP+NY ++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 222 ASE--KPVSPKSGTLKSP 237
+E PV P + + +P
Sbjct: 806 ENEVPAPVKPVTDSTSAP 823
Score = 51.2 bits (121), Expect = 4e-06
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 12/92 (13%)
Query: 173 NFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGR-----TGWFPSNYVREVKASEKPV 227
++ T ++L+ + G +I + + GGWWEG L R GWFP+NYV+ + +
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKI 1143
Query: 228 SPKSGTLKSPPKGFDTTAINK--SYYNVVLQN 257
+P PPK A+ + Y+ QN
Sbjct: 1144 TP-----TEPPKSTALAAVCQVIGMYDYTAQN 1170
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 2/73 (2%)
Query: 166 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKAS-E 224
L +A + ++ ++ L+F+K DVI V ++ WW G + G+ GWFP +YV+ +
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLE-QQDMWWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 225 KPVSPKSGTLKSP 237
K S SG+ +SP
Sbjct: 975 KSTSMDSGSSESP 987
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 33/306 (10%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTS------EKLSSANISYLMGNLEEICSFQQM 307
VL IL TE +Y L+ + S +L ++ + + L+ N+ L N+E+I +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 308 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 364
+ +LE C P++Q +G FL + +Y YC+NH A+ +L E ++ + F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
Query: 365 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 421
+ + G + L L P R+ KYP LLKEL + H D +Q ++ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
Query: 422 NLSAQCQEVRKRKE-LE-LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY 479
+ + E +++ E LE L+ L I WEG ++ + + L++ + + ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ-ERA 290
Query: 480 LLLFPNVLLMLSASPRMSG---------------FIYQGKLPTTGMTITKLED--SENHR 522
LF N+L+ R++G +I++G++ T M + +ED ++ H
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHS 350
Query: 523 NAFEIS 528
N + ++
Sbjct: 351 NGYTVT 356
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 307
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 308 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 364
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 365 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 421
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 422 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 478
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 479 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 521
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 522 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 555
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 95.5 bits (236), Expect = 2e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 307
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 308 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 364
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 365 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 421
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 422 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 478
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 479 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 521
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 522 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 555
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 86.7 bits (213), Expect = 8e-17
Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 20/373 (5%)
Query: 247 NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQ 306
+K+Y+ + + + TE Y K+L+ + S + + + + A S + N E + F
Sbjct: 539 DKAYF--IAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHT 596
Query: 307 MLVQSLEECTKLPEAQ--------QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---T 355
++ +E+ L E + QR+G L + MK L + H A+ L
Sbjct: 597 NFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHL-AAHLWKHSEALEALENGI 655
Query: 356 EHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQK 415
+ S L F L L T L +P RL Y +L+ L +H H D +D +
Sbjct: 656 KSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRA 715
Query: 416 SMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEK 475
++A + AQ + E Q L E ++ G D + ++ + +
Sbjct: 716 ALAEITEMVAQLHGTMIKME-NFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGL 774
Query: 476 NERYLLLFPNVLLMLSASPRMSG-FIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIER 534
+R LF +VLL S S F G+LP GMTI + ED + + G +
Sbjct: 775 QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQR-QS 833
Query: 535 ILVSCNNQQDLQEWVEHLQKQ---TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 591
I+V+ +++ ++++WVE +Q + +S P S P + P + D
Sbjct: 834 IIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDL 893
Query: 592 PAPLTPAYHTLPH 604
A T PH
Sbjct: 894 SASRTSLERQAPH 906
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/313 (24%), Positives = 145/313 (46%), Gaps = 22/313 (7%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKL--SSANISYLMGNLEEICSFQQMLVQS 311
V + I+ETE Y ++L++++ YL PL L S + L N+E+I F L++
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
Query: 312 LEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFMETKG 369
LE + + + CF+ +Y YC N+PS++ +L E S +++ +
Sbjct: 166 LENSS----SAGGIAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
Query: 370 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHTDRQDIQKSMAAFKNLSAQC 427
A L L + L KP R+ KY LL+EL +H + R+ +++++ + ++
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
Query: 428 QEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSE--EKNERYLLLF 483
++++++E LQ + + W G ++ G + G ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
Query: 484 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMI--ERILVSCNN 541
+LL+ A R + Y+G + ++++ +S F++S I R L+ N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
Query: 542 QQDLQEWVEHLQK 554
Q++ + W+ LQ+
Sbjct: 396 QEEKRLWIHCLQR 408
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 79.3 bits (194), Expect = 1e-14
Identities = 80/348 (22%), Positives = 152/348 (43%), Gaps = 16/348 (4%)
Query: 219 EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLST-YL 277
E K E+ L+ + + N+ + + +L TE Y L + Y
Sbjct: 175 ETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYC 234
Query: 278 RPLQTSEKLS--SANISYLMGNLEEICSFQ-QMLVQSLEECTKLPEAQQRVGGCFLNLMP 334
+ L+ + + S + ++ + N+ I +F + L+ LE+ + E R+G L P
Sbjct: 235 KLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAP 294
Query: 335 QMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLD 390
+K +Y Y +A+ ++ +E + +F E + G L L + +P R+
Sbjct: 295 FLK-MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIP 353
Query: 391 KYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE-VRKRKELELQILTEAIRNWE 449
+Y LLK+ R + D D +KS+ ++ +RK + L+ + + E
Sbjct: 354 RYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEE 413
Query: 450 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG--FIYQGKLPT 507
D + + Q+L A + ERYL LF N+LL + G F + ++
Sbjct: 414 EDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGI 473
Query: 508 TGMTITKLEDSENHRNAFEISGSMIERIL-VSCNNQQDLQEWVEHLQK 554
GM I + + +E + + F++SG ER L + ++ QD +EW++ LQ+
Sbjct: 474 DGMKIVETQ-NEEYPHTFQVSGK--ERTLELQASSAQDKEEWIKALQE 518
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 79.0 bits (193), Expect = 2e-14
Identities = 77/340 (22%), Positives = 145/340 (42%), Gaps = 18/340 (5%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 313
+++ IL TE Y K+L+ + + + + + + ++ L N++ I F + ++ +E
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598
Query: 314 ECTKLPE---------AQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---TEHSEEL 361
+ L E + QR+G L M Q+K + +Y H + L T+ ++L
Sbjct: 599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKE-FTSYFQRHDEVLTELEKATKRCKKL 657
Query: 362 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 421
+ L L T L KP RL Y LL+ L H H D D ++ A
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717
Query: 422 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 481
++ Q + R E LQ LTE R+ G + ++ + + + +R
Sbjct: 718 EVTTTLQHILIRLE-NLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFF 776
Query: 482 LFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 540
LF ++LL S S F +G LP GM + + ++ + + F I + + I+V+ +
Sbjct: 777 LFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ-KTIVVAAS 835
Query: 541 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 580
+ + ++W+ L + G T ++P T+ + P
Sbjct: 836 TRLEKEKWMLDLNSAIQAAKSGGDTAP--ALPGRTVCTRP 873
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/322 (23%), Positives = 154/322 (47%), Gaps = 50/322 (15%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTS-EKLSSANIS---YLMGNLEEICSFQQ-ML 308
++ +++TE Y ++L+ + TYL + + E++ ++ + GN++EI F +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 309 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS-EELGEFMET 367
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1356 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQR 1411
Query: 368 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAA-------- 419
G ++ +++ L KP R+ KY LLKEL E+ + +D + M +
Sbjct: 1412 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1467
Query: 420 --FKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNE 477
L + + + EL IL E+ + W D KTL + E
Sbjct: 1468 MHLSMLEGFDENIESQGEL---ILQESFQVW---DPKTL---------------IRKGRE 1506
Query: 478 RYLLLFPNVLLM---LSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI--SGSMI 532
R+L LF L+ + S S ++Y+ KL T+ + +T+ + + + A + + +
Sbjct: 1507 RHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSD 1566
Query: 533 ERILVSCNNQQDLQEWVEHLQK 554
+I++ ++ ++ Q+W++H+++
Sbjct: 1567 NKIVLKASSIENKQDWIKHIRE 1588
Score = 70.9 bits (172), Expect = 4e-12
Identities = 75/361 (20%), Positives = 161/361 (44%), Gaps = 38/361 (10%)
Query: 213 PSNYVREVKASEKP-VSPKSGTLKSPPKGFD------TTAINKSYYNVVLQNILETENEY 265
PS+ + + S P +P +L S D ++++ + +Y VLQ ++ETE +Y
Sbjct: 1927 PSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHY--VLQELVETERDY 1984
Query: 266 SKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQ-MLVQSLEECTKLPEAQ 322
++L V+ Y+ ++ + GN+ +I + + + LE+C + PE
Sbjct: 1985 VRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE-- 2042
Query: 323 QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGL 382
++G F+ ++ +Y+ YC N P + ++++E+ + E ++ + L LT L
Sbjct: 2043 -KLGSLFVKHERRLH-MYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR---LQLTDLL 2097
Query: 383 SKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT 442
KP R+ KY LLK+ ++ + D ++++++ + +C ++ L+
Sbjct: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQ----- 2152
Query: 443 EAIRNWEGDDIKTLGNVTYMSQVLI--QCAGSEEK-NERYLLLFPNVLLMLSASPRMSGF 499
++G I G + L+ Q AG + ER + LF +++ + GF
Sbjct: 2153 ----GFDG-KIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGF 2207
Query: 500 IYQGKLPTTGMTITKL---EDSENHRNAFEI---SGSMIERILVSCNNQQDLQEWVEHLQ 553
G L + ++ L E+ EN F + +G ++E ++ ++ Q W+ +
Sbjct: 2208 SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEIN 2267
Query: 554 K 554
+
Sbjct: 2268 Q 2268
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 308
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 309 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 367
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 368 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 427
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 428 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 481 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 535
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 536 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 591
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
Score = 69.3 bits (168), Expect = 1e-11
Identities = 109/512 (21%), Positives = 210/512 (41%), Gaps = 61/512 (11%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQ-MLV 309
VL +++TE +Y K+L V+ +++ ++ E + + + GN+ +I + + +
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFL 1991
Query: 310 QSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKG 369
LE+C + Q R+ F+ ++ +Y+ YC N P + ++ E+ E +
Sbjct: 1992 AELEKCI---QEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDAYFEEVKQEIN 2047
Query: 370 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE 429
L L+ L KP R+ KY LLK+ R+ E + DI+K++ + +C +
Sbjct: 2048 QR----LTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND 2103
Query: 430 VRKRKELELQILTEAIRNWEGD---DIKTLGNVTYMSQVLIQCAGSEEK-NERYLLLFPN 485
+ L+ +EG K L T+ V+ AG + + ER + LF
Sbjct: 2104 MMNLGRLQ---------GFEGTLTAQGKLLQQDTF--YVIELDAGMQSRTKERRVFLFEQ 2152
Query: 486 VLL---MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQ 542
+++ +L G++++ + + + + D++ + A ++ ER+++ N
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSERVVLQAANA 2211
Query: 543 QDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTL 602
Q WV+ + N ++ + L S P+ K + PA L
Sbjct: 2212 DIQQAWVQDI----------NQVLETQRDFLNALQS-PIEYQRKERSTAVMRSQPA--RL 2258
Query: 603 PHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKL 662
P S P++++ G +PPK S P PPL+ S + + SP
Sbjct: 2259 PQASPR--PYSSVPAGSEKPPK-----GSSYNPPLPPLKISTS-------NGSPGFEYHQ 2304
Query: 663 LPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNH 722
+ K +D + S+ A+ +D LK E + + Q L Q L++
Sbjct: 2305 PGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQP 2364
Query: 723 VLADDDQPSLDSLGRRSSLSRLEPSDLSEDSD 754
A D P+ + S L+ L + +E SD
Sbjct: 2365 --ASDHSPAAEGWVPGSILAPLTKATAAESSD 2394
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 308
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 309 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 367
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 368 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 427
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 428 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 480
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 481 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 535
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 536 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 591
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 78.2 bits (191), Expect = 3e-14
Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 23/213 (10%)
Query: 217 VREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTY 276
+ E+ S++ SP+ T P + V+ +LETE Y K+L ++ Y
Sbjct: 1009 LHEMNPSDQSPSPQDST--GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066
Query: 277 LRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ------------ 323
L+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 1067 LKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLF 1126
Query: 324 RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVLTTG 381
+GG FL + K LY +CA+H VL + + F++ + L +
Sbjct: 1127 SLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESY 1185
Query: 382 LSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 409
L KP R+ KYP LL+EL E YH D
Sbjct: 1186 LIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 237 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 296
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
Query: 297 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 343
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
Query: 344 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 401
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
Query: 402 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 432
+ + + +++ A + +++ E++K
Sbjct: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 237 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 296
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
Query: 297 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 343
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
Query: 344 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 401
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
Query: 402 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 432
+ + + +++ A + +++ E++K
Sbjct: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 77.8 bits (190), Expect = 4e-14
Identities = 119/522 (22%), Positives = 209/522 (40%), Gaps = 98/522 (18%)
Query: 1 MNSAEQTVTWLITLGVLESPKKTISDPEGF---LQASLKDGVVLCRLLERLLPGTIEKV- 56
M Q WLI VL P + P L +L+DGV+LC+LL L PG+I+
Sbjct: 1 MEQWRQCGRWLIDCKVLP-PNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKD 59
Query: 57 --YPEPRSESECLSNIREFLRGCGASLRL---ETFDANDLYQGQNFNKVLSSLVTLNKVT 111
+ S+ CL NIR FL+ C L E FD DL+ ++F KV+S++ L
Sbjct: 60 INFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRL---- 115
Query: 112 ADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAK 171
S+ + + I+ F S T++ YRSL+
Sbjct: 116 --------SLHSIAQNKGIRPFPS-------EETTENDDDVYRSLE-------------- 146
Query: 172 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 231
+ +E +L D+ E+GG + ++ E K
Sbjct: 147 ---ELADEHDLG---EDIYDCVPCEDGG--------------DDIYEDIIKVEVQQPMKM 186
Query: 232 GTLKSPPKGFDTTAINKS---YYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSS 288
G + + I ++ YY + + + E Y L+ VL S
Sbjct: 187 GMTEDDKRNCCLLEIQETEAKYY----RTLEDIEKNYMSPLRLVL-------------SP 229
Query: 289 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHP 348
A+++ + NLE++ +++++ + + FL+ ++ +Y YC++
Sbjct: 230 ADMAAVFINLEDLIKVHHSFLRAID--VSVMVGGSTLAKVFLDFKERL-LIYGEYCSHME 286
Query: 349 SAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHME 404
A N L + +F E G L L P R+ KY LLKEL H
Sbjct: 287 HAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA 346
Query: 405 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIK--TLGNVTYM 462
+ +RQ +++++ A ++L+ EV++ KE L+ ++E + E +K G
Sbjct: 347 E-RPERQQLKEALEAMQDLAMYINEVKRDKE-TLRKISEFQSSIENLQVKLEEFGRPKID 404
Query: 463 SQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGK 504
++ ++ + K +RYL LF V+++ + G+ Y+ K
Sbjct: 405 GELKVRSIVNHTKQDRYLFLFDKVVIVC----KRKGYSYELK 442
Score = 55.5 bits (132), Expect = 2e-07
Identities = 25/52 (48%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 170 AKFNFQQTNEDELSFSKGDVIHV-TRVE-EGGWWEGTLNGRTGWFPSNYVRE 219
A++NF + ELS +GDV+ + +R+ + GWW+G NGR GWFPS YV E
Sbjct: 784 ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEE 835
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 74.3 bits (181), Expect = 4e-13
Identities = 48/197 (24%), Positives = 96/197 (48%), Gaps = 19/197 (9%)
Query: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 313
V++ +L+TE +Y ++L+ + + P+Q ++ + + + L GN++ + + L+ +LE
Sbjct: 788 VIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALE 846
Query: 314 ECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFMETKGAS 371
VG FL +++ Y YC NH A+ +L E E++ + ++ A
Sbjct: 847 -------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899
Query: 372 SPGI---------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKN 422
+ + L + L KP R+ +YP LL EL + H D+ + ++ A K
Sbjct: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959
Query: 423 LSAQCQEVRKRKELELQ 439
++ E ++RK+L L+
Sbjct: 960 INVNINEYKRRKDLVLK 976
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 170 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR---EVKASEKP 226
A + FQ +EL F GD I + E GW EG+L GRTG FP +V+ + + E
Sbjct: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETM 309
Query: 227 VSPKSGTLKSPPK 239
P+ G+L P+
Sbjct: 310 ALPQEGSLARIPE 322
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/49 (44%), Positives = 28/49 (57%)
Query: 169 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 217
RA ++EL F +GDVI + V E GW+EG L GR G FP +V
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 144 RTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEE----GG 199
RT++ + + D ++ NQ V A + F+ N +ELS S + + ++
Sbjct: 1495 RTAQAPEDRSTEPDGSEAEGNQ-VYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTE 1553
Query: 200 WWEGTLNGRTGWFPSNYVREVK 221
WW +NG+ G+ PSNY+R+ +
Sbjct: 1554 WWLAEVNGKKGYVPSNYIRKTE 1575
Score = 38.1 bits (87), Expect = 0.032
Identities = 22/54 (40%), Positives = 29/54 (53%)
Query: 167 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 220
VVRA F+F + +EL GD+I V V + W G TG FPS++V V
Sbjct: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV 59
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 174 FQQTNEDELSFSKGDVIHVTRVEEGGWWEG-TLNGRTGWFPSNYVREVKASEK 225
F D L +GD++ + + GW +G + G G+FPS+ VRE+ S +
Sbjct: 77 FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 73.2 bits (178), Expect = 9e-13
Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 31/270 (11%)
Query: 291 ISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSA 350
+SYL + EI ++M VQ L + E +Y YC N+P++
Sbjct: 91 LSYLGRVVREIVETERMYVQDLRSIVESQEFD----------------IYTQYCNNYPNS 134
Query: 351 VNVLTE--HSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHT 408
V LTE ++ +F + L L + L KP R+ KY LL+E+ +H ++
Sbjct: 135 VAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED 194
Query: 409 DRQDIQKSMAAFKNLSAQCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVL 466
+ ++ ++ ++ ++++R E + LQ + + NW+G D+ T G +
Sbjct: 195 GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFR 254
Query: 467 IQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFE 526
+ +NER LF LL+ R F+Y+G +P + + L +S F
Sbjct: 255 VH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSL---MLIESTRDSLCFT 305
Query: 527 IS--GSMIERILVSCNNQQDLQEWVEHLQK 554
++ ++ + ++ + W H+++
Sbjct: 306 VTHYKHSKQQYSIQAKTVEEKRNWTHHIKR 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,754,238
Number of Sequences: 37866
Number of extensions: 1612165
Number of successful extensions: 6867
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 372
Number of HSP's that attempted gapping in prelim test: 5698
Number of HSP's gapped (non-prelim): 1249
length of query: 782
length of database: 18,247,518
effective HSP length: 110
effective length of query: 672
effective length of database: 14,082,258
effective search space: 9463277376
effective search space used: 9463277376
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.