Guide to the Human Genome
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Search of human proteins with 219555716

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219555716 synaptonemal complex central element protein 1
isoform 3 [Homo sapiens]
         (318 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219555716 synaptonemal complex central element protein 1 isof...   627   e-180
gi|219555718 synaptonemal complex central element protein 1 isof...   601   e-172
gi|18640754 synaptonemal complex central element protein 1 isofo...   560   e-160
gi|194018732 hypothetical protein LOC100130958 [Homo sapiens]         197   1e-50
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         65   1e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    63   4e-10
gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein...    62   5e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        62   7e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        62   7e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         62   7e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         62   7e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         62   7e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         62   7e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         62   7e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         62   7e-10
gi|169208036 PREDICTED: similar to Golgin subfamily A member 8-l...    61   1e-09
gi|239745147 PREDICTED: similar to Golgin subfamily A member 8-l...    61   1e-09
gi|51317366 myosin XVIIIB [Homo sapiens]                               60   3e-09
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]           60   3e-09
gi|239745132 PREDICTED: similar to Golgin subfamily A member 8-l...    60   3e-09
gi|239745130 PREDICTED: similar to Golgin subfamily A member 8-l...    60   3e-09
gi|169208014 PREDICTED: Golgin subfamily A member 8-like protein...    60   3e-09
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 60   3e-09
gi|169208517 PREDICTED: similar to Golgin subfamily A member 8-l...    59   4e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    59   4e-09
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]           59   6e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    59   7e-09
gi|239745111 PREDICTED: Golgin subfamily A member 8-like protein...    59   7e-09
gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-l...    58   1e-08
gi|42794779 myosin 18A isoform b [Homo sapiens]                        57   2e-08

>gi|219555716 synaptonemal complex central element protein 1 isoform
           3 [Homo sapiens]
          Length = 318

 Score =  627 bits (1617), Expect = e-180
 Identities = 318/318 (100%), Positives = 318/318 (100%)

Query: 1   MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI 60
           MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI
Sbjct: 1   MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI 60

Query: 61  NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE 120
           NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE
Sbjct: 61  NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE 120

Query: 121 SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER 180
           SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER
Sbjct: 121 SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER 180

Query: 181 LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV 240
           LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV
Sbjct: 181 LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV 240

Query: 241 QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
           QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE
Sbjct: 241 QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300

Query: 301 AGPGDVAPRPGRPVTWWS 318
           AGPGDVAPRPGRPVTWWS
Sbjct: 301 AGPGDVAPRPGRPVTWWS 318


>gi|219555718 synaptonemal complex central element protein 1 isoform
           4 [Homo sapiens]
          Length = 351

 Score =  601 bits (1549), Expect = e-172
 Identities = 309/311 (99%), Positives = 310/311 (99%), Gaps = 1/311 (0%)

Query: 1   MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI 60
           MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI
Sbjct: 1   MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI 60

Query: 61  NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE 120
           NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE
Sbjct: 61  NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE 120

Query: 121 SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER 180
           SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER
Sbjct: 121 SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER 180

Query: 181 LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV 240
           LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV
Sbjct: 181 LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV 240

Query: 241 QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
           QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE
Sbjct: 241 QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300

Query: 301 AGPGDVA-PRP 310
           AGPGDVA P+P
Sbjct: 301 AGPGDVASPKP 311


>gi|18640754 synaptonemal complex central element protein 1 isoform
           1 [Homo sapiens]
          Length = 282

 Score =  560 bits (1442), Expect = e-160
 Identities = 282/282 (100%), Positives = 282/282 (100%)

Query: 37  MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV 96
           MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV
Sbjct: 1   MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV 60

Query: 97  HLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRL 156
           HLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRL
Sbjct: 61  HLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRL 120

Query: 157 AFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSL 216
           AFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSL
Sbjct: 121 AFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSL 180

Query: 217 CGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQ 276
           CGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQ
Sbjct: 181 CGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQ 240

Query: 277 RLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPGRPVTWWS 318
           RLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPGRPVTWWS
Sbjct: 241 RLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPGRPVTWWS 282


>gi|194018732 hypothetical protein LOC100130958 [Homo sapiens]
          Length = 242

 Score =  197 bits (501), Expect = 1e-50
 Identities = 120/250 (48%), Positives = 158/250 (63%), Gaps = 39/250 (15%)

Query: 16  AVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLG 75
           A +  E+A GQ   S K EDL+ MV KLQK GSLEP++E LI+RIN++QQAKKK++++L 
Sbjct: 12  APEATEEAEGQ-AKSLKTEDLLAMVIKLQKEGSLEPQIEDLISRINDLQQAKKKSSEELR 70

Query: 76  EARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKE 135
           E  ++ EAL +ELDSL+GEKVHL+E+L KKQE LRIL++HCQEKESEA R          
Sbjct: 71  ETHSLWEALHRELDSLNGEKVHLEEVLGKKQEALRILQMHCQEKESEAQR---------- 120

Query: 136 RISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPE-RLAKEICALDSSKEQ 194
                               L    QLEDLMGQHKDLW+FHM E RLA+EI AL+ SKEQ
Sbjct: 121 --------------------LDVRGQLEDLMGQHKDLWEFHMLEQRLAREIRALERSKEQ 160

Query: 195 LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
           LL E +LV+A L +V+ +L S    EG   +++GL        A +++F E+ R A E+ 
Sbjct: 161 LLSERRLVRAKLREVERRLHSPPEVEGAMAVNDGL-------KAELEIFGEQVRSAPEVG 213

Query: 255 AAAAQRHQQL 264
           A   +   +L
Sbjct: 214 AGEGEAGPEL 223


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 70/299 (23%), Positives = 130/299 (43%), Gaps = 36/299 (12%)

Query: 11   EPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKA 70
            E  +G+  ++E AG  + +  K+E L   V KL++    +      + R  E ++A +  
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR-- 1157

Query: 71   NKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------- 119
                 E  +  E LQ +L+    E  H +  L+  Q  L   R   Q+            
Sbjct: 1158 ----AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213

Query: 120  ---ESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLR---LAFEEQLEDLMGQHKDLW 173
                 EA RK++++   +E +S LN Q+ E++ + ++L+   +A  E+ + L  + + L 
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ 1273

Query: 174  --DFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGL-- 229
                    R A+   AL    + L +E +  +   E+++ +L S   AE    L + L  
Sbjct: 1274 AETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS--QAERAEELGQELKA 1331

Query: 230  ----FLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
                F + ++A +T+QL   EH   + L++         QQ   +Q    +R +EELE+
Sbjct: 1332 WQEKFFQKEQALSTLQL---EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ 1387



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 64/298 (21%), Positives = 133/298 (44%), Gaps = 19/298 (6%)

Query: 16  AVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLG 75
           A +R      +D + +++E L +  +K  K+  L+ +++V     +  Q +  +A ++  
Sbjct: 589 AEEREASLRERDAALKQLEALEK--EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646

Query: 76  EARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTM---LQE 132
           E     E LQ  +++   E+   +  +++ +  LR  +    EKE  A  K  +   LQ 
Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706

Query: 133 CKERISALNLQIEEEKNKQRQLRLAFEEQ---LEDLMGQHKDLWDFHMPER--LAKEICA 187
            KE +      +EEEK +      A EEQ   + +L  + + L + H  ER  L +E   
Sbjct: 707 LKESLKVTKGSLEEEKRRAAD---ALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763

Query: 188 LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
               + +L +  +  +A  E ++ +L     A+   T +       +E AA  + +++  
Sbjct: 764 RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ--HTAESECEQLVKEVAAWRERYEDSQ 821

Query: 248 RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEE---LEKHG-MQVPAQAQSTQEEEA 301
           ++  +  A   ++   L+++C++ +Q+ Q  KE+   +E H  +Q+  Q     E  A
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 67/280 (23%), Positives = 117/280 (41%), Gaps = 24/280 (8%)

Query: 26  QDTSSQKIEDLMEMV-----QKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTI 80
           Q+ +SQ +   +E +     QK Q++  +  + E    R +  QQ    A +     R  
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA--TRQDHAQQLATAAEEREASLRER 599

Query: 81  CEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISAL 140
             AL K+L++L  EK    EIL ++ +     R   Q   ++A R+     E   ++  L
Sbjct: 600 DAAL-KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA---ELSRKVEEL 655

Query: 141 NLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEK 200
              +E  + +Q + +    E    L  + +   +    ER+A+E   L    + L +  K
Sbjct: 656 QACVETARQEQHEAQAQVAELELQLRSEQQKATE---KERVAQEKDQLQEQLQALKESLK 712

Query: 201 LVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQR 260
           + K +LE+ K +            L+E     S+  A T  L ++  R+ +EL    A R
Sbjct: 713 VTKGSLEEEKRR--------AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR 764

Query: 261 HQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
            + L+ + QQ  +  Q   E L +   +  A AQ T E E
Sbjct: 765 -KGLEARLQQLGEAHQAETEVLRRELAEAMA-AQHTAESE 802



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 61/300 (20%), Positives = 117/300 (39%), Gaps = 47/300 (15%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKLQKV-----GSLEPRVEVLINRINEVQQAKKKANKDLG 75
           +KA  ++  +Q+ + L E +Q L++      GSLE       + + E Q+   +      
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK---A 741

Query: 76  EARTICEALQKELDSLHGEKV-------HLKEILSKKQETLRILRLHCQEKESEAHRKHT 128
           E R++ E  ++E   L  E+         L+++    Q    +LR    E  +  H   +
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 801

Query: 129 MLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICAL 188
             ++  + ++A   + E+ + ++ Q    F+EQL  L             E   K    L
Sbjct: 802 ECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK------------EECEKARQEL 849

Query: 189 DSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHR 248
             +KE++   E   +  +   +++L  L                    A  +Q  QE+  
Sbjct: 850 QEAKEKVAGIESHSELQISRQQNELAEL----------------HANLARALQQVQEKEV 893

Query: 249 KAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAP 308
           +A++L    A     LQ+K     ++  RL+  + K G Q    ++   +E A  GD  P
Sbjct: 894 RAQKL----ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP 949



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 58/290 (20%), Positives = 133/290 (45%), Gaps = 26/290 (8%)

Query: 41  QKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKE 100
           ++ Q++ SL   ++  I+ +++ ++  ++A++  G   T       ++ SL  E   L  
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA------QVASLTSELTTLNA 512

Query: 101 ILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEE----KNKQRQLRL 156
            + ++ + L  L+   +EK+++  +    LQ+ ++    L  Q+E+     K K++QL+ 
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQT---LQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569

Query: 157 AFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQL--LKEEKLVKATLEDVKHQLC 214
             E+Q E     H         ER A  +   D++ +QL  L++EK  K  +   + Q+ 
Sbjct: 570 VAEKQ-EATRQDHAQQLATAAEEREAS-LRERDAALKQLEALEKEKAAKLEILQQQLQVA 627

Query: 215 SLCGAEGPSTLDEG------LFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKC 268
           +       +++ +       L  + +E  A V+  ++E  +A+  +A    + +  QQK 
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687

Query: 269 QQQQ---QKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPGRPVT 315
            +++   Q++ +L+E+L+     +     S +EE+    D      R ++
Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 80/333 (24%), Positives = 132/333 (39%), Gaps = 59/333 (17%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTI 80
           E++   +   +  E+   + +K  ++  ++ R++ L   +NE Q A     K+L E R  
Sbjct: 226 ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKELEELRDK 284

Query: 81  CEALQ-------KELDSLHGEKVHLKEILSKKQET-------LRILRLHCQEKE------ 120
            E+L        K+   L  EK  +   +++  E        LR    H Q+ +      
Sbjct: 285 NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNEL 344

Query: 121 SEAHRKHTMLQECKERISALNLQIE---------EEKNKQRQLRLAFEE----QLEDLMG 167
           +E H K T  QE  E+ + L  ++          EEKN+  Q +L+  E    QL+D   
Sbjct: 345 TEEHSKAT--QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402

Query: 168 QHKD--LWDFHMPERLAKEICALDSSKEQLL------------KEEKLV--KATLEDVKH 211
           Q K   L D    E L +E   L ++  QL             +E KL+  +   E+ K 
Sbjct: 403 QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462

Query: 212 QLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQ 271
           QL SL      + L   +   SQ      Q  Q    +    +A+       L    QQQ
Sbjct: 463 QLSSLI-----TDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517

Query: 272 QQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPG 304
            Q+   LK++ ++   Q+    Q  Q+E+A  G
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQ--QQEQASQG 548



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 67/287 (23%), Positives = 115/287 (40%), Gaps = 56/287 (19%)

Query: 42   KLQKVGSL-EPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKEL----DSLHGEKV 96
            +LQ++G   +   EVL   + E   A+  A  +       CE L KE+    +     + 
Sbjct: 770  RLQQLGEAHQAETEVLRRELAEAMAAQHTAESE-------CEQLVKEVAAWRERYEDSQQ 822

Query: 97   HLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALN----LQIEEEKNKQR 152
               +  +  QE L  L+  C++   E       LQE KE+++ +     LQI  ++N+  
Sbjct: 823  EEAQYGAMFQEQLMTLKEECEKARQE-------LQEAKEKVAGIESHSELQISRQQNELA 875

Query: 153  QLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE----EKLVK----- 203
            +L       L+ +  Q K++      ++LA ++  L        KE    E LV+     
Sbjct: 876  ELHANLARALQQV--QEKEV----RAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929

Query: 204  ---ATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQR 260
               A+ E VK    +  G   P  L+E    + ++  +T    Q   R+AE++     + 
Sbjct: 930  QETASRELVKEP--ARAGDRQPEWLEEQ---QGRQFCSTQAALQAMEREAEQMGNELERL 984

Query: 261  HQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVA 307
               L +   QQQ++R          G Q    A+ TQE      D+A
Sbjct: 985  RAALMESQGQQQEER----------GQQEREVARLTQERGRAQADLA 1021



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 65/304 (21%), Positives = 126/304 (41%), Gaps = 45/304 (14%)

Query: 4    RSLTSKAEPTAGAVDRAEKAGGQDTSSQKI-EDLMEMVQKLQKVGSLEPRVEVLINRINE 62
            R     AE  A      ++   ++  +QK+ +DL  + +K+        R+E L+ +  E
Sbjct: 869  RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928

Query: 63   VQQ-AKKKANKDLGEA-------------RTIC------EALQKELDSLHGEKVHLKEIL 102
             Q+ A ++  K+   A             R  C      +A+++E + +  E   L+  L
Sbjct: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988

Query: 103  SKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAF---E 159
             + Q          QE+  +  R+   L + + R  A +L +E+    + ++RL     E
Sbjct: 989  MESQGQQ-------QEERGQQEREVARLTQERGRAQA-DLALEKAARAELEMRLQNALNE 1040

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGA 219
            +++E    Q          E   +E+  L   +   +KE + ++ T++ +K QL     A
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL-----A 1095

Query: 220  EGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLK 279
            +       G   +S+ A  T    +    K E L A  ++    L+Q+CQ+QQ++   L+
Sbjct: 1096 KKEKEHASGSGAQSEAAGRT----EPTGPKLEALRAEVSK----LEQQCQKQQEQADSLE 1147

Query: 280  EELE 283
              LE
Sbjct: 1148 RSLE 1151



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 82/327 (25%), Positives = 143/327 (43%), Gaps = 62/327 (18%)

Query: 4    RSLTSKAEPTAGAVDRAEKAGG-----QDTSSQKIEDL----MEMVQKLQKVGSLEPRVE 54
            + LTS+AE       RAE+ G      Q+   QK + L    +E       V  L P   
Sbjct: 1313 QELTSQAE-------RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365

Query: 55   VLINRINEVQQAKKKANKDLGEARTICEALQKELDSLH---GEKVHLKEILSKKQETLRI 111
            +      E   A+K+  ++L +++     L+ EL       GE + L++ +++++ T + 
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425

Query: 112  LRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKD 171
            LR    EK S A +  +ML++    ++  N  + E  N  RQ        LE  + Q + 
Sbjct: 1426 LRA---EKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQF-------LEVELDQAR- 1473

Query: 172  LWDFHMPERLAKEICALDSSKEQLLKE-EKLVKATLEDVKHQLCSLCGAEGPSTLDEGLF 230
                   E+  +E+ A+ +  E  L E ++  ++T  +++       GA+    L+E   
Sbjct: 1474 -------EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK-VKVLEERQR 1525

Query: 231  LRSQEAAATVQL-----FQEEHRK-AEEL---LAAAAQRHQQLQQKCQ-------QQQQK 274
             + +    T Q+     FQ E  K  EEL   LA + Q  +  QQK +       + QQ+
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE 1585

Query: 275  RQRLKEELEKHGMQVPAQAQSTQEEEA 301
             QRL+ +L +       QAQ +Q+E+A
Sbjct: 1586 AQRLQAQLNE------LQAQLSQKEQA 1606



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 61/296 (20%), Positives = 117/296 (39%), Gaps = 63/296 (21%)

Query: 35   DLMEMVQKLQKVGSLEPRVEVL----------INRINEVQQAKKKANKDLGEARTIC-EA 83
            +L E++   QKV   E   + L          ++ + +      + N+ LGE   +  + 
Sbjct: 1405 ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQF 1464

Query: 84   LQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQ 143
            L+ ELD    + V          + L  +R   + + +E  R+    Q     +  +  +
Sbjct: 1465 LEVELDQAREKYV----------QELAAVRADAETRLAEVQRE---AQSTARELEVMTAK 1511

Query: 144  IEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMP-----ERLAKEICALDSSKEQLLKE 198
             E  K K  + R  F+E+ + L  Q + L  F        E L+K++   DS +   +++
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA--DSDQASKVQQ 1569

Query: 199  EKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH---------RK 249
            +KL                 A+G  +  E   L++Q      QL Q+E           K
Sbjct: 1570 QKLKAVQ-------------AQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616

Query: 250  AEELLAAAAQRHQQLQQKCQQQQQ----------KRQRLKEELEKHGMQVPAQAQS 295
            A+    A  Q++Q+LQ++ +  +Q          + +RL  EL++ G++     Q+
Sbjct: 1617 AKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQT 1672



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 52/259 (20%), Positives = 106/259 (40%), Gaps = 41/259 (15%)

Query: 17   VDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            +D+A +   Q+ ++ + +    + +  ++  S    +EV+  +    +    +  +   E
Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKK-----------QETLRILRLHCQEKESEAHR 125
             R    A  ++L+    E+    E LSKK           Q+ L+ ++    E + EA R
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588

Query: 126  KHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEI 185
                L E + ++S      E  K +  + +  ++ + +    Q+++L      E+L    
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ----QNQEL-----QEQLR--- 1636

Query: 186  CALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQE 245
                 S EQL KE K ++A  E + H+L             +   L+++EA  T +    
Sbjct: 1637 -----SLEQLQKENKELRAEAERLGHEL-------------QQAGLKTKEAEQTCRHLTA 1678

Query: 246  EHRKAEELLAAAAQRHQQL 264
            + R  E  +A A Q+ + L
Sbjct: 1679 QVRSLEAQVAHADQQLRDL 1697



 Score = 28.9 bits (63), Expect = 6.3
 Identities = 33/166 (19%), Positives = 62/166 (37%), Gaps = 7/166 (4%)

Query: 1    MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI 60
            +A     SK +       +A+    Q  + +    L E+  +L +        ++ + + 
Sbjct: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617

Query: 61   NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEIL-------SKKQETLRILR 113
                 AKK+ N++L E     E LQKE   L  E   L   L        + ++T R L 
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT 1677

Query: 114  LHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFE 159
               +  E++       L++  +   A +     E   + QL L+ +
Sbjct: 1678 AQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSID 1723


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 59/303 (19%), Positives = 146/303 (48%), Gaps = 22/303 (7%)

Query: 18  DRAEKAGGQDTSSQKIEDLM-EMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
           ++ EK   Q+   ++ E++M E  +K+++   +    E  + R  E+   K++  +   E
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 384

Query: 77  ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHC-QEKESEAHRKHTMLQECKE 135
                E   +EL+    E+  ++E   K+QE  +I      QE+E++  R+   ++E +E
Sbjct: 385 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 444

Query: 136 RISALNLQI--------EEEKNKQRQLRLAFEE--QLEDLMGQHKDLWDFHMPERLAKEI 185
           +I     ++        E+EK ++ + R   EE  + E+ + + +++W     E++ ++ 
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW--RQKEKMHEQE 502

Query: 186 CALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQE 245
             +   +E++ ++E+ ++   E ++ Q   +   E      E ++   ++     ++++E
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE 562

Query: 246 EHR--------KAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQ 297
           E R        + EE +    ++  + ++K ++Q++KRQ  +E++ K   ++  Q +  Q
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622

Query: 298 EEE 300
           E+E
Sbjct: 623 EQE 625



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 49/259 (18%), Positives = 122/259 (47%), Gaps = 17/259 (6%)

Query: 44  QKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTIC--EALQKELDSLHGEKVHLKEI 101
           +K   L+ +++++ +  +E+Q   K+  + L  A+ +   + LQ E D L  E   +   
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280

Query: 102 LSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQ 161
           L  + E   +     Q++E +  R+   +QE +E+I     +I E++ K R       EQ
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-------EQ 333

Query: 162 LEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEG 221
            E +  Q + +W+    E++ ++   +   +E++ ++E+++    E ++ Q       E 
Sbjct: 334 EEKMRRQEEMMWE--KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ------EEM 385

Query: 222 PSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEE 281
               +E +    ++     ++ ++E ++ EE      ++ Q+ + K  +Q++K +  +E+
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445

Query: 282 LEKHGMQVPAQAQSTQEEE 300
           + +   ++  Q +   E+E
Sbjct: 446 IREQEKKMWRQEEKIHEQE 464



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 52/299 (17%), Positives = 138/299 (46%), Gaps = 26/299 (8%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKA---NKDLGEA 77
           EK   Q+   Q+ E + E  ++ ++   +  + E +  +  ++++ +KK     + + E 
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 463

Query: 78  RTICEALQKELDS---LHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECK 134
             I E  +++         EK+H +E + +++E     ++H QE++     +    QE K
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE-----KMHEQEEKIRKQEEKVWRQEEK 518

Query: 135 ERISALNLQIEEEKNKQRQLRLAFEEQL---EDLMGQHKDLWDFH----MPERLAKEICA 187
            R     ++ +EEK  +++ ++  +E++   E+ M + + +W+        +++ ++   
Sbjct: 519 IREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEK 578

Query: 188 LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLF------LRSQEAAATVQ 241
           +   +E++ ++E+ ++   E  + Q   +   E      E         +R QE     Q
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ 638

Query: 242 LFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             +E  ++ EE +    ++  + ++K Q+Q++   R +E++ +   ++  Q +  +E+E
Sbjct: 639 --EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695



 Score = 36.6 bits (83), Expect = 0.030
 Identities = 25/167 (14%), Positives = 78/167 (46%), Gaps = 2/167 (1%)

Query: 18  DRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
           ++ EK   Q+   ++ E+  +  ++ +K+   E ++     +I E ++  ++  + + E 
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQ--EQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ 638

Query: 78  RTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERI 137
             + +  ++++     +    +E + +++ET+       +E+E +   +   ++E +E +
Sbjct: 639 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMM 698

Query: 138 SALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKE 184
                ++ E++ K  +     +EQ E +  Q + +W+  +  R  +E
Sbjct: 699 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 37/181 (20%), Positives = 87/181 (48%), Gaps = 16/181 (8%)

Query: 26  QDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEV----QQAKKKANKDLGEARTIC 81
           ++   Q+ ED  +M ++ +K+   E +V     +I E     Q+ ++K  K   + R   
Sbjct: 561 EEEKRQEQED--KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618

Query: 82  EALQKELDSLHG--EKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISA 139
           E +Q++ + +    EK+  +E ++++QE          E+E +   +   +QE +E +  
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEE------KMGEQEEKMCEQEEKMQEQEETMWR 672

Query: 140 LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEE 199
              +I E++ K R+      EQ E +  Q + +W+    E++ ++   +   +E++ ++E
Sbjct: 673 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE--QEEKMCEQEEKMQEQEEKMRRQE 730

Query: 200 K 200
           +
Sbjct: 731 E 731



 Score = 29.3 bits (64), Expect = 4.8
 Identities = 55/241 (22%), Positives = 90/241 (37%), Gaps = 48/241 (19%)

Query: 67  KKKANKDLGEARTI---CEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEA 123
           KKK N       T    C + + E  + H  +  L+  L  +  T+RIL   CQ+ E   
Sbjct: 87  KKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILT--CQKTE--- 141

Query: 124 HRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAK 183
                           L + +   ++  +QL    E +  DL+ +  D W F      A 
Sbjct: 142 ----------------LQMALYYSQHAVKQL----EGEARDLISRLHDSWKFAGELEQAL 181

Query: 184 EICALDSSK-----EQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAA 238
              A    K     E+L KE   +  +LE  ++ +            DE L  ++ +   
Sbjct: 182 SAVATQKKKADRYIEELTKERDAL--SLELYRNTIT-----------DEELKEKNAKLQE 228

Query: 239 TVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQE 298
            +QL + E  K+E  L     + +  + K    QQ+ Q   + L K    V A+ Q+  E
Sbjct: 229 KLQLVESE--KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286

Query: 299 E 299
           E
Sbjct: 287 E 287


>gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein 3
           [Homo sapiens]
          Length = 580

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 69/286 (24%), Positives = 129/286 (45%), Gaps = 30/286 (10%)

Query: 28  TSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQK 86
           TSS  ++DL    Q+   V  S    +  L N I  ++Q KK+    L E +      QK
Sbjct: 67  TSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQK 126

Query: 87  -------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESE-AHRKHTMLQECKERIS 138
                  ++ +L+ +K  L   L   + +LR    + +EK  + A R    LQ   E  S
Sbjct: 127 AKRVLEVQIQTLNIQKEELNTDLYHMKRSLR----YFEEKSKDLAVRLQHSLQRKGELES 182

Query: 139 ALNLQIEEEKNKQRQLRLAFEE-QLE-DLMGQH----KDLWDFHMPERLAKEICALDSSK 192
            L+  +  +K K  Q + +F++ QLE D   +H    +  W   M  ++++EIC L   K
Sbjct: 183 VLSNVMATQKKKANQFKESFQQVQLERDEYSEHLKGERARWQQRM-RKMSQEICTLKKEK 241

Query: 193 EQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEE 252
           +Q ++  + ++ +L  +K+Q+      E P+   E            +Q  ++E  +   
Sbjct: 242 QQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSE----------VELQHLRKELERVAG 291

Query: 253 LLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQE 298
            L A  + +Q++    Q+Q+++ +  +E L K   ++  Q +S Q+
Sbjct: 292 ELQAQVKNNQRISLLNQRQEERIREQEERLRKQEERIQEQHKSLQQ 337


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2372 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2420

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2531

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2532 EEQQRQQ--QQMEQERQRLVASMEE 2554



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1599 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1650

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1701

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2407 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2454

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2455 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2499

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2500 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1987

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1988 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2028

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2089 AAEEAEEARVQAEREA 2104



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1348

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1349 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1389

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1390 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1442

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1495

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1496 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1532



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1985 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2039

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2040 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2089

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKH 2170



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2228 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2286 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1284

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1397

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEE 1421


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2376 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2424

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2535

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2536 EEQQRQQ--QQMEQERQRLVASMEE 2558



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1545 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1602

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1603 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1654

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1705

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2411 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2458

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2459 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2503

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2504 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1991

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1992 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2032

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2093 AAEEAEEARVQAEREA 2108



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1352

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1353 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1393

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1394 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1446

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1499

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1500 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1536



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1989 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2043

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2044 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2093

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKH 2174



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2171

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2232 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2290 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1232 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1288

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1401

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEE 1425


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2372 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2420

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2531

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2532 EEQQRQQ--QQMEQERQRLVASMEE 2554



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1599 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1650

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1701

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2407 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2454

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2455 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2499

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2500 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1987

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1988 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2028

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2089 AAEEAEEARVQAEREA 2104



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1348

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1349 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1389

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1390 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1442

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1495

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1496 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1532



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1985 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2039

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2040 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2089

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKH 2170



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2228 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2286 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1284

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1397

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEE 1421


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2340 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2388

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2499

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2500 EEQQRQQ--QQMEQERQRLVASMEE 2522



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1509 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1566

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1567 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1618

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1669

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2375 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2422

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2423 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2467

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2468 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1955

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1956 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 1996

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2057 AAEEAEEARVQAEREA 2072



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1316

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1317 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1357

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1358 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1410

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1463

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1464 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1500



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1953 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2007

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2008 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2057

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKH 2138



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2135

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2196 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2254 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1196 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1252

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1365

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEE 1389


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2509 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2557

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2668

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2669 EEQQRQQ--QQMEQERQRLVASMEE 2691



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1678 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1735

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1736 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1787

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1838

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2544 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2591

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2592 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2636

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2637 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 2124

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 2125 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2165

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2226 AAEEAEEARVQAEREA 2241



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1485

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1486 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1526

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1527 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1579

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1632

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1633 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1669



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 2122 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2176

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2177 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2226

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKH 2307



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2365 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2423 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1365 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1421

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1534

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEE 1558


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2350 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2398

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2509

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2510 EEQQRQQ--QQMEQERQRLVASMEE 2532



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1519 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1576

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1577 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1628

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1679

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2385 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2432

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2433 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2477

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2478 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1965

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1966 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2006

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2067 AAEEAEEARVQAEREA 2082



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1269 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1326

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1327 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1367

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1368 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1420

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1473

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1474 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1510



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1963 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2017

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2018 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2067

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKH 2148



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2145

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2206 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2264 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1206 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1262

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1375

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEE 1399


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2358 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2406

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2517

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2518 EEQQRQQ--QQMEQERQRLVASMEE 2540



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1527 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1584

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1585 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1636

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1687

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2393 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2440

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2441 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2485

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2486 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 1973

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 1974 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2014

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2075 AAEEAEEARVQAEREA 2090



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1277 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1334

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1335 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1375

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1376 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1428

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1481

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1482 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1518



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 1971 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2025

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2026 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2075

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKH 2156



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2153

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2214 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2272 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1214 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1270

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1383

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEE 1407


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 75/265 (28%), Positives = 121/265 (45%), Gaps = 38/265 (14%)

Query: 36   LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE-ARTICEALQKELDSLHGE 94
            L E +Q +Q+   L+   E+L  +    Q+  ++  +D  + A+ + E  Q    +L  E
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398

Query: 95   KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
            +    E +S + E L++       + +E  R     +E  +R      Q EE   K  + 
Sbjct: 2399 RQRQLE-MSAEAERLKL-------RVAEMSRAQARAEEDAQRFRK---QAEEIGEKLHRT 2447

Query: 155  RLAFEEQLE-----DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDV 209
             LA +E++      ++  Q  D    H  ERL + I  L+  KE+L +E KL++   E++
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSD----HDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503

Query: 210  K----HQLCSLCGAEGPSTLDE--GLFLRS----QEAAATVQLFQEEHRKAEELLAAAAQ 259
            +     QL     A   S L E   L  R     QE A   QLFQ+E  KA++L     +
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL-----R 2558

Query: 260  RHQQLQQKCQQQQQKRQRLKEELEK 284
              QQ QQ  QQ +Q+RQRL   +E+
Sbjct: 2559 EEQQRQQ--QQMEQERQRLVASMEE 2581



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 30/294 (10%)

Query: 19   RAEKAGGQDTSSQK-IEDLMEMVQ-KLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGE 76
            RAE+A  Q   +Q+  E L   VQ + Q+    E  +   +    E  + K++A + L E
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 77   ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQEC--K 134
             R   E  ++ L     E+    ++  +  +  R      Q K +    K   L+    +
Sbjct: 1568 LRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSLQE 1625

Query: 135  ERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ 194
            E ++   L+ E E+  Q+Q   A  E+  +   +  + W     E L   + A     E+
Sbjct: 1626 EHVAVAQLREEAERRAQQQ---AEAERAREEAERELERWQLKANEALRLRLQA-----EE 1677

Query: 195  LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELL 254
            + +++ L +A  E  K +        G +          ++A    +L ++E  K  +L 
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKA---------EEQAVRQRELAEQELEKQRQLA 1728

Query: 255  AAAAQRHQQLQQKC-------QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEA 301
               AQ+    +Q+        +Q +Q+RQ L+EEL +   +  A  Q  QE EA
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 50/278 (17%)

Query: 26   QDTSSQKIEDLMEMVQKLQKVGSLEPR--------VEVLINRINEVQQAKKKANKDLGEA 77
            Q+   Q  + L E  Q  Q+    E +         E L  R+ E+ +A+ +A +D    
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433

Query: 78   RTICEALQKELDSLHGEKVHLKEILSKKQETL-RILRLHCQEKESEAHRKHTMLQECKER 136
            R   E +        GEK+H  E+ ++++ TL + L +  Q+ + +A R    + E    
Sbjct: 2434 RKQAEEI--------GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE---- 2481

Query: 137  ISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSS----K 192
                   +E EK K +Q     + + E++    +        E+L +E  AL  S    K
Sbjct: 2482 -------LEREKEKLQQEAKLLQLKSEEMQTVQQ--------EQLLQETQALQQSFLSEK 2526

Query: 193  EQLLKEEKLV---KATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQ---EAAATVQLFQEE 246
            + LL+ E+ +   KA LE    QL     A+     +E    + Q   E    V   +E 
Sbjct: 2527 DSLLQRERFIEQEKAKLE----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582

Query: 247  HRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             R+  E      ++ ++LQQ  QQ++Q+ + L EE ++
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 77/316 (24%), Positives = 134/316 (42%), Gaps = 59/316 (18%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKVGS---LEPRVEVLINRIN-EVQQAKKKANKDL 74
            R  +   +D + Q+ E    + +KL  +G    L+   E+ +     E ++ ++ A  + 
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901

Query: 75   GEARTICEA--------------LQKELDS-LHGEKVHLKEIL-SKKQETLRILRLHCQE 118
             + R + E               L+K  DS L  +K  +++ L  ++Q    IL L    
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961

Query: 119  KESEAHRKHTMLQECKERISA---LNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDF 175
            +++ A +    L+  + R +A   L  + + E    RQ +LA EE+      +       
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE------- 2014

Query: 176  HMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRS-- 233
               ER+ K + A + +  Q        KA LE+V+            + ++E   LR   
Sbjct: 2015 ---ERVQKSLAAEEEAARQR-------KAALEEVERL---------KAKVEEARRLRERA 2055

Query: 234  -QEAAATVQLFQEEHRK---AEELLAAAA--QRHQQLQQKCQQQQQKRQRLKEELE--KH 285
             QE+A  +QL QE  +K   AEE   A A  Q+ Q+LQQ  QQ+Q    +L+ E E  + 
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 286  GMQVPAQAQSTQEEEA 301
              +   +A+   E EA
Sbjct: 2116 AAEEAEEARVQAEREA 2131



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 56/293 (19%), Positives = 132/293 (45%), Gaps = 51/293 (17%)

Query: 8    SKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAK 67
            ++ EP A    + +   G ++  Q+  DL     +L  + S    ++ +   +  +++ +
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS--QYIKFISETLRRMEEEE 1375

Query: 68   KKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKH 127
            + A +   E                 E+  L E+ +  ++  ++   H Q K ++A R+ 
Sbjct: 1376 RLAEQQRAE-----------------ERERLAEVEAALEKQRQLAEAHAQAK-AQAERE- 1416

Query: 128  TMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICA 187
               +E ++R+    ++ EE     +Q + + +E+L+ L    +        +  A++  A
Sbjct: 1417 --AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-----EIQAKARQAEA 1469

Query: 188  LDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEH 247
             + S+ ++ +E ++V+  LE  + Q     GAEG     + L  R++EA A  +  QEE 
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRG---GAEGEL---QALRARAEEAEAQKRQAQEE- 1522

Query: 248  RKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
                          ++L+++ Q + Q++++ + EL     +V A+A++ +E++
Sbjct: 1523 -------------AERLRRQVQDESQRKRQAEVEL---ASRVKAEAEAAREKQ 1559



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/262 (23%), Positives = 109/262 (41%), Gaps = 26/262 (9%)

Query: 34   EDLMEMVQKLQKVGSLEPRVEVLINRI--NEVQQAKKKANKDLGEARTICEALQKELDSL 91
            E+++ +    +K  + +  +E+ + RI  N     + K   +L  AR    A ++E    
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2011

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKE------SEAHRKHTMLQECKERISALNLQIE 145
              E+  +++ L+ ++E  R  +   +E E       EA R    L+E  E+ SA  LQ+ 
Sbjct: 2012 EAEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR----LRERAEQESARQLQLA 2066

Query: 146  EEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKAT 205
            +E     Q RL  EE+      Q K+     + + L +E   LD    QL  E +  +  
Sbjct: 2067 QEA---AQKRLQAEEKAHAFAVQQKEQ---ELQQTLQQEQSVLD----QLRGEAEAARRA 2116

Query: 206  LEDVKHQLCSLC--GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQ 263
             E+ +          A+    ++E   L+ Q A    Q   +    AE+L   A Q   +
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLK-QSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175

Query: 264  LQQKCQQQQQKRQRLKEELEKH 285
              Q  Q   +++Q    E+EKH
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKH 2197



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 70/329 (21%), Positives = 136/329 (41%), Gaps = 52/329 (15%)

Query: 19   RAEKAGGQDTSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKKKANKDLGEA 77
            +AE+        QK ++L + +Q+ Q V   L    E       E ++A+ +A ++  ++
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134

Query: 78   RTICEALQK------ELDSLHGEKVHLKEILSKKQETLRILRLHCQEK----------ES 121
            R   E  ++      E      +     E L K+ E     R   ++           E 
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2194

Query: 122  EAHRK---HTMLQECK--ERISALNLQIEEEKNKQRQL-----------------RLAFE 159
            E H+K    T+ Q+ +  + ++ L LQ+EE  +++  L                 R   E
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254

Query: 160  EQLEDLMGQHKDLWDFHMPERLAKEICAL-----DSSKEQLLKE-EKLVKATLEDVKHQL 213
            E+L  +  Q ++L    +  R+  E  AL     D+++  L +E EK+ +   E  +  +
Sbjct: 2255 EELFSVRVQMEEL--SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312

Query: 214  CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEEL--LAAAAQRHQQLQQKCQQQ 271
             +   A      +E L   +Q+ A   ++ +E+ +  +E   L A A+  QQ ++  Q+Q
Sbjct: 2313 AAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369

Query: 272  QQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             ++ Q  KE++ +   +     Q T E E
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

Query: 104  KKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLE 163
            ++QE ++ + L   +   E  R+   L E  ER      ++EE +   +Q   A ++   
Sbjct: 1255 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE---KVEECQRFAKQYINAIKDYEL 1311

Query: 164  DLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKE--------EKLVKATLEDVKHQLCS 215
             L+     L     P +  K    + S  E +++E         +L   T + +K    +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPK----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367

Query: 216  LCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKR 275
            L   E    L E      +E  A V+   E+ R+  E   A AQ   Q +++ ++ QQ+ 
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE---AHAQAKAQAEREAKELQQRM 1424

Query: 276  QRLKEELEKHGMQVPAQAQSTQEE 299
            Q      E+  +    Q +S QEE
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEE 1448


>gi|169208036 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 isoform 2 [Homo sapiens]
          Length = 601

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 69/339 (20%)

Query: 37  MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV 96
           +E+ Q    + SL+ + + + +++ E ++A  K  K         + L  + + L+ +  
Sbjct: 90  VEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLY 149

Query: 97  HLKEIL---SKKQETLRILRLHCQEKESEAH-----------------------RKHTML 130
           H+K  L    +K + L +   H  +++ E                         R    L
Sbjct: 150 HMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKL 209

Query: 131 QECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDS 190
           ++     + L +Q+ + K   +Q++L  +E  E L G+ +  W   M  ++++EIC L  
Sbjct: 210 EQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGE-RARWQQRM-RKMSQEICTLKK 267

Query: 191 SKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDE----------------------- 227
            K+Q ++  + ++ +L  +K+Q+      E P+   E                       
Sbjct: 268 EKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKK 327

Query: 228 --GLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQ------------- 272
              + L +Q     +Q  +E  RK EE +    ++H+ LQQ  + Q              
Sbjct: 328 NQRISLLNQRQEERIQEQEERLRKQEERIQ---EQHKSLQQLAKPQSVFEEPNNENKNAL 384

Query: 273 QKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPG 311
           Q  Q++KE  EK G     +  + +E EA  G  AP PG
Sbjct: 385 QLEQQVKELQEKLGEVKETETSAQKEPEAARGPGAPGPG 423


>gi|239745147 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 isoform 1 [Homo sapiens]
          Length = 630

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 67/312 (21%), Positives = 132/312 (42%), Gaps = 53/312 (16%)

Query: 28  TSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKK----------KANKDLGE 76
           TSS  ++DL    Q+   V  S    +  L N I  ++Q KK          KAN    +
Sbjct: 67  TSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQK 126

Query: 77  ARTICEA----LQKELDSLHGEKVHLKEIL---SKKQETLRILRLHCQEKESEAH----- 124
           A+ + E     L  + + L+ +  H+K  L    +K + L +   H  +++ E       
Sbjct: 127 AKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSN 186

Query: 125 ------------------RKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLM 166
                             R    L++     + L +Q+ + K   +Q++L  +E  E L 
Sbjct: 187 VMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLK 246

Query: 167 GQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLD 226
           G+ +  W   M  ++++EIC L   K+Q ++  + ++ +L  +K+Q+      E P+   
Sbjct: 247 GE-RARWQQRM-RKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPS 304

Query: 227 EGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHG 286
           E            +Q  ++E  +    L A  +++Q++    Q+Q+++ Q  +E L K  
Sbjct: 305 E----------VELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQE 354

Query: 287 MQVPAQAQSTQE 298
            ++  Q +S Q+
Sbjct: 355 ERIQEQHKSLQQ 366


>gi|51317366 myosin XVIIIB [Homo sapiens]
          Length = 2567

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 70/323 (21%), Positives = 144/323 (44%), Gaps = 74/323 (22%)

Query: 38   EMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVH 97
            ++ QK Q+   L+ +VE+L +   E+       +  LGE       L++ L  L    + 
Sbjct: 1647 QLKQKEQEASQLKQQVEMLQDHKRELL-----GSPSLGE--NCVAGLKERLWKLESSALE 1699

Query: 98   LKEILSKKQETL---------------RILRLHCQEKESEAHRKHTMLQECKERISALNL 142
             ++I S+++ T+               R+ ++H +++E +      + Q C++R+  L +
Sbjct: 1700 QQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLHQLEM 1759

Query: 143  QIEEEKNKQRQLRLAFEEQLEDLMGQHKDLW---DFHMPERLAKEICALDS--------- 190
            Q+E+E  +++Q+ L  ++ LE L+G   D     DF + +RL +++    +         
Sbjct: 1760 QLEQEY-EEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLL 1818

Query: 191  ----------SKEQL-----------------LKEEKLVKATLEDVKHQLCSLCGAEGPS 223
                      SKE+L                 LK +K++ A LE +  +L ++      S
Sbjct: 1819 GTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADLESMHSELENM--TRNKS 1876

Query: 224  TLDEGLFLRSQEAAATVQLFQEEHRKAEELL----------AAAAQRHQQLQQKCQQQQQ 273
             +DE L+    E A  ++   E+     EL+          AA   + Q+LQ + ++ ++
Sbjct: 1877 LVDEQLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKK 1936

Query: 274  KRQRLKEELEKHGMQVPAQAQST 296
            ++ +L+E+L+   M++    QST
Sbjct: 1937 EKHKLQEQLQVAQMRIEYLEQST 1959



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 49/234 (20%), Positives = 97/234 (41%), Gaps = 22/234 (9%)

Query: 60   INEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEK 119
            + ++QQ  K+  ++  + +   E LQ     L G     +  ++  +E L  L     E+
Sbjct: 1641 LGQLQQQLKQKEQEASQLKQQVEMLQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQ 1700

Query: 120  ESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPE 179
            +    ++   +++ ++      L+IE  K   ++ R   EE+LED+             +
Sbjct: 1701 QKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVR------------Q 1748

Query: 180  RLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFL-----RSQ 234
               K +  L+   EQ  +E+++V    +D++  + +LC   G    D    L     R+ 
Sbjct: 1749 SCQKRLHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTH 1808

Query: 235  EAAATVQLF--QEEHRKAEELLAAAAQRHQQLQQ---KCQQQQQKRQRLKEELE 283
               + VQL     E  K         + H QL+Q   KC++  + ++ L  +LE
Sbjct: 1809 ALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADLE 1862



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 55/255 (21%), Positives = 107/255 (41%), Gaps = 21/255 (8%)

Query: 49   LEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQET 108
            L  R++    R++    A+K+  + LGE ++  +  +K    L  +  HL   L    E 
Sbjct: 1532 LRKRLQQCEERLDSELTARKELEQKLGELQSAYDGAKKMAHQLKRKCHHLTCDL----ED 1587

Query: 109  LRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEE--KNKQRQLRLAFEEQLEDLM 166
              +L  + Q +  E  +K        +   AL   + E+  + K  Q   +   +L  L 
Sbjct: 1588 TCVLLENQQSRNHELEKKQKKFD--LQLAQALGESVFEKGLREKVTQENTSVRWELGQLQ 1645

Query: 167  GQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLD 226
             Q K         +L +++  L   K +LL    L +  +  +K +L  L      S+  
Sbjct: 1646 QQLKQ--KEQEASQLKQQVEMLQDHKRELLGSPSLGENCVAGLKERLWKL-----ESSAL 1698

Query: 227  EGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQ-QQQKRQRLKEELEKH 285
            E   ++SQ+     QL Q   R   E+     +R +Q+ QK ++ Q+++ + +++  +K 
Sbjct: 1699 EQQKIQSQQENTIKQLEQLRQRFELEI-----ERMKQMHQKDREDQEEELEDVRQSCQKR 1753

Query: 286  GMQVPAQAQSTQEEE 300
              Q+  Q +   EE+
Sbjct: 1754 LHQLEMQLEQEYEEK 1768


>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
          Length = 1257

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 66/268 (24%), Positives = 125/268 (46%), Gaps = 18/268 (6%)

Query: 27  DTSSQKIEDLMEMVQKLQ-KVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQ 85
           D +SQ +E L E+++K   ++  ++ R+  L +R+ EV+Q  + A KDL +   +    Q
Sbjct: 265 DETSQIVE-LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQ 323

Query: 86  KELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIE 145
           +++     E +  KE + ++  TL    L  Q + +  H  +  L+       A+  Q+ 
Sbjct: 324 RDI----REAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQM- 378

Query: 146 EEKNKQRQLRLAFEEQ-LEDLMGQHKDLWDFHMPERLAKEICALDSSKEQ---LLKEEKL 201
           EEKN+Q Q RL   EQ L+  M + + L +  +   LA+ I AL  ++E+   + +  + 
Sbjct: 379 EEKNRQLQERLELAEQKLQQTMRKAETLPE--VEAELAQRIAALTKAEERHGNIEERMRH 436

Query: 202 VKATLEDVKHQL-----CSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAA 256
           ++  LE+   +L           E    L + +     E+   +QL  +E   A E    
Sbjct: 437 LEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNV 496

Query: 257 AAQRHQQLQQKCQQQQQKRQRLKEELEK 284
             Q  +  ++  ++    ++RL EE+EK
Sbjct: 497 LIQESETFRKNLEESLHDKERLAEEIEK 524



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 50/196 (25%), Positives = 93/196 (47%), Gaps = 19/196 (9%)

Query: 26  QDTSSQKIEDLME--MVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEA 83
           + TS   + D +E  +  K   +  +E +   L  R+   + A++K  + + +A T+ E 
Sbjct: 353 ESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERL---ELAEQKLQQTMRKAETLPE- 408

Query: 84  LQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESE---AHRKHTMLQECKERISAL 140
           ++ EL          +E     +E +R L    +EK  E   A ++  M +E  +R+S  
Sbjct: 409 VEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDT 468

Query: 141 NLQIEEEKNKQRQLRL-----AFEEQ---LEDLMGQHKDLWD-FHMPERLAKEICALDSS 191
             ++  E N++ QL L     A EE+   +++     K+L +  H  ERLA+EI  L S 
Sbjct: 469 VDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSE 528

Query: 192 KEQL-LKEEKLVKATL 206
            +QL ++   L++ T+
Sbjct: 529 LDQLKMRTGSLIEPTI 544


>gi|239745132 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 [Homo sapiens]
          Length = 602

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 70/339 (20%), Positives = 134/339 (39%), Gaps = 69/339 (20%)

Query: 37  MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV 96
           +E+ Q    + SL+ + + + +++ E ++A  K  K         + L  +   L+ +  
Sbjct: 90  VEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKGKLNTDLY 149

Query: 97  HLKEIL---SKKQETLRILRLHCQEKESEAH-----------------------RKHTML 130
           H+K  L    +K + L +   H  +++ E                         R    L
Sbjct: 150 HMKRSLRYFEEKSKDLAVCLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKL 209

Query: 131 QECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDS 190
           ++     + L +Q+ + K   +Q++L  +E  E L G+ +  W   M  ++++EIC L  
Sbjct: 210 EQSMREEALLKVQLTQLKESFQQVQLERDECAEHLKGE-RARWQQRM-RKMSQEICTLKK 267

Query: 191 SKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDE----------------------- 227
            K+Q ++  + ++ +L  +K+Q+      E P+   E                       
Sbjct: 268 EKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKK 327

Query: 228 --GLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQ------------- 272
              + L +Q     +Q  +E  RK EE +    ++H+ LQQ  + Q              
Sbjct: 328 NQRISLLNQRQEERIQEQEERLRKQEERIQ---EQHKSLQQLAKPQSVFEEPNNENKNAL 384

Query: 273 QKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPG 311
           Q  Q++KE  EK G     +  + +E EA  G  AP PG
Sbjct: 385 QLEQQVKELQEKLGEVKETETSAQKEPEAARGPGAPGPG 423


>gi|239745130 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 isoform 1 [Homo sapiens]
          Length = 632

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 67/312 (21%), Positives = 132/312 (42%), Gaps = 53/312 (16%)

Query: 28  TSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKK----------KANKDLGE 76
           TSS  ++DL    Q+   V  S    +  L N I  ++Q KK          KAN    +
Sbjct: 67  TSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQK 126

Query: 77  ARTICEALQKELD----SLHGEKVHLKEIL---SKKQETLRILRLHCQEKESEAH----- 124
           A+ + E   + L+     L+ +  H+K  L    +K + L +   H  +++ E       
Sbjct: 127 AKRVLEVQIQTLNIQKGKLNTDLYHMKRSLRYFEEKSKDLAVCLQHSLQRKGELESVLSN 186

Query: 125 ------------------RKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLM 166
                             R    L++     + L +Q+ + K   +Q++L  +E  E L 
Sbjct: 187 VMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDECAEHLK 246

Query: 167 GQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLD 226
           G+ +  W   M  ++++EIC L   K+Q ++  + ++ +L  +K+Q+      E P+   
Sbjct: 247 GE-RARWQQRM-RKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPS 304

Query: 227 EGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHG 286
           E            +Q  ++E  +    L A  +++Q++    Q+Q+++ Q  +E L K  
Sbjct: 305 E----------VELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQE 354

Query: 287 MQVPAQAQSTQE 298
            ++  Q +S Q+
Sbjct: 355 ERIQEQHKSLQQ 366


>gi|169208014 PREDICTED: Golgin subfamily A member 8-like protein 3
           isoform 2 [Homo sapiens]
          Length = 602

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 70/336 (20%), Positives = 133/336 (39%), Gaps = 63/336 (18%)

Query: 37  MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKV 96
           +E+ Q    + SL+ + + + +++ E ++A  K  K         + L  + + L+ +  
Sbjct: 90  VEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLY 149

Query: 97  HLKEIL---SKKQETLRILRLHCQEKESEAH-----------------------RKHTML 130
           H+K  L    +K + L +   H  +++ E                         R    L
Sbjct: 150 HMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKL 209

Query: 131 QECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDS 190
           ++     + L +Q+ + K   +Q++L  +E  E L G+ +  W   M  ++++EIC L  
Sbjct: 210 EQSMREEALLKVQLTQFKESFQQVQLERDEYSEHLKGE-RARWQQRM-RKMSQEICTLKK 267

Query: 191 SKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDE------------------GLFLR 232
            K+Q ++  + ++ +L  +K+Q+      E P+   E                       
Sbjct: 268 EKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKN 327

Query: 233 SQEAAATVQLFQEEHRKAEELLAAAAQR----HQQLQQKCQQQQ-------------QKR 275
           +Q  +   Q  +E  R+ EE L    +R    H+ LQQ  + Q              Q  
Sbjct: 328 NQRISLLNQRQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFKEPNNENKNALQLE 387

Query: 276 QRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPG 311
           Q++KE  EK G     +  + +E EA  G  AP PG
Sbjct: 388 QQVKELQEKLGEVKETETSAQKEPEAARGPGAPGPG 423


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 85/333 (25%), Positives = 145/333 (43%), Gaps = 50/333 (15%)

Query: 4    RSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQK--VGSLEPRVEVLINRIN 61
            R +  + +    A +++E+A       + ++ L E ++  +K  V +LE      + R+ 
Sbjct: 719  RQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 778

Query: 62   EVQQAKKKA-----NKDLGEARTICEA-LQKELDSLHGEKVHLKE--ILSKKQETLRILR 113
               +AK +       K + EA+   EA LQK L  +   +VH K   +   + E   +LR
Sbjct: 779  SSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-HRVHQKSYHVAGYEHELSSLLR 837

Query: 114  LHCQEKESEAHRKHTMLQECKERISA-LNLQIEEEKNKQR------------QLRLAFEE 160
               QE E E  R+   ++E  +++ A    Q E E+ KQR            +L+ A E 
Sbjct: 838  EKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHER 897

Query: 161  QLEDL-MGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKL-VKATLEDVKHQLCSL-- 216
            +LE +   QHK L D     R           +E+ L++ +L ++   +DVK +L  L  
Sbjct: 898  ELETVRQEQHKRLEDLRRRHR----------EQERKLQDLELDLETRAKDVKARLALLEV 947

Query: 217  ----CGAEGPSTLD--EGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQ---- 266
                   E    LD    + L+S+EA AT Q  +E  ++   LL +  Q  + L +    
Sbjct: 948  QEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR 1007

Query: 267  --KCQQQQQKRQRLKEELEKHGMQVPAQAQSTQ 297
              K + Q    Q   ++L+KH   + A+AQ  Q
Sbjct: 1008 KLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 44/190 (23%), Positives = 92/190 (48%), Gaps = 7/190 (3%)

Query: 99  KEILSKKQETLRILRLH-CQEKESEAHRKHTMLQECKERISALNLQIEEE-KNKQRQLRL 156
           + +L  KQE ++ LR   CQE+E E  R H   Q+ ++ +S+L  ++++  + ++ ++R 
Sbjct: 608 RHLLESKQEKMQQLREKLCQEEEEEILRLH---QQKEQSLSSLRERLQKAIEEEEARMRE 664

Query: 157 AFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSL 216
              ++L  L  Q +        +  A++  +L   +E+L  ++K  +A+LE    Q+   
Sbjct: 665 EESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQ 724

Query: 217 CGAE-GPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQ-QLQQKCQQQQQK 274
              E   S   E   L + +  A  QL ++   + +E +A   + H  +L++ C   + K
Sbjct: 725 LKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAK 784

Query: 275 RQRLKEELEK 284
            + +   L+K
Sbjct: 785 HREVVSSLQK 794



 Score = 36.6 bits (83), Expect = 0.030
 Identities = 28/104 (26%), Positives = 52/104 (50%), Gaps = 6/104 (5%)

Query: 198 EEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAA 257
           EEK+  +    V  ++ S      P  L E      +EA A  Q+ +++ R    LL + 
Sbjct: 560 EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA--QVLEQDQR---HLLESK 614

Query: 258 AQRHQQLQQK-CQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
            ++ QQL++K CQ+++++  RL ++ E+    +  + Q   EEE
Sbjct: 615 QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEE 658



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 71/331 (21%), Positives = 141/331 (42%), Gaps = 67/331 (20%)

Query: 15   GAVDRAEKAGGQDTSS------QKIEDLM----EMVQKLQKVG-SLEPRVEVLINRIN-- 61
            G ++R ++A  ++  +      +++EDL     E  +KLQ +   LE R + +  R+   
Sbjct: 886  GELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945

Query: 62   EVQQ--AKKKANKDLGEARTIC------EALQKELDSLHGEKVHLKEILSKKQETLRILR 113
            EVQ+  A+++  + L   R +        A  ++L+    E  HL +   + +E L  L+
Sbjct: 946  EVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ 1005

Query: 114  LHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLA-------FEEQL--ED 164
                + ES+        Q+ ++  S+L  + +++++  R++ +        FE  L  ED
Sbjct: 1006 ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIED 1065

Query: 165  L---------------MGQHKD------LWDFHMPERLAKEICALDSSKEQLLKE----- 198
            L               + Q K+      L   ++   L+ E  AL S+KE L+++     
Sbjct: 1066 LRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125

Query: 199  --EKLVKATLEDVKHQLCSLCG-AEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLA 255
              +  +KA  +  +H+L S    A+ P  +     +R           ++E R  +E+ +
Sbjct: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKN--------LEKETRHLDEMKS 1177

Query: 256  AAAQRHQQLQQKCQQQQQKRQRLKEELEKHG 286
            A  + H  L++K ++  Q    L EE    G
Sbjct: 1178 AMRKGHNLLKKKEEKLNQLESSLWEEASDEG 1208


>gi|169208517 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 isoform 2 [Homo sapiens]
          Length = 602

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 81/347 (23%), Positives = 143/347 (41%), Gaps = 59/347 (17%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKL-QKVGSLEPRVEVLINRINEVQQAKKKANKDLGEART 79
           E+A   D+ S +I  L   ++ L Q+   +E ++E      N+ Q+AK+     L     
Sbjct: 80  ERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQLQTLNI 139

Query: 80  ICEALQKELDSLHGE-----------KVHLKEILSKKQETLRILR--LHCQEKE------ 120
             E L  +L  +               V L+  L +K E   +L   +  Q+K+      
Sbjct: 140 QKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSS 199

Query: 121 -SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPE 179
            S+A  +  + Q  +E  + L +Q+ + K   +Q++L  +E  E L G+ +  W   M  
Sbjct: 200 PSKAGTEWKLEQSMREE-ALLKVQLTQLKESFQQVQLERDEYSEHLKGE-RARWQQRM-R 256

Query: 180 RLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDE------------ 227
           ++++EIC L   K+Q ++  + ++ +L  +K+Q+      E P+   E            
Sbjct: 257 KMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELER 316

Query: 228 ------GLFLRSQEAAATVQLFQEEHRKAEELLAAAAQR----HQQLQQKCQQQQ----- 272
                      +Q  +   Q  +E  R+ EE L    +R    H+ LQQ  + Q      
Sbjct: 317 VAGELQAQVKNNQRISLLNQRQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFEEP 376

Query: 273 --------QKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPG 311
                   Q  Q++KE  EK G    ++  + +E EA  G  AP PG
Sbjct: 377 NNENKSTLQLEQQVKELQEKLGEVKESETSAQKEPEAARGPAAPGPG 423


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 51/260 (19%), Positives = 124/260 (47%), Gaps = 12/260 (4%)

Query: 44  QKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTIC--EALQKELDSLHGEKVHLKEI 101
           +K   L+ +++++ +  +E+Q   K+  + L  A+ +   + LQ E D L  E   +   
Sbjct: 209 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268

Query: 102 LSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQ 161
           L  + E   +     Q++E +  R+   +QE +E+I     +I E++ K R+      E+
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK 328

Query: 162 LEDLMGQHKDLWDFHMPER-LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAE 220
            E +  Q + +W+     R L +++   +  +EQ  K ++  K   ++ + +  +    +
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388

Query: 221 GPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKE 280
                ++   +R QE     ++ QE+    EE +    ++  + +++ Q+Q++K +R +E
Sbjct: 389 EEKIREQEEKIREQE-----EMMQEQ----EEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439

Query: 281 ELEKHGMQVPAQAQSTQEEE 300
           ++ +   ++  Q +  +E+E
Sbjct: 440 KIREQEKKIREQEEKIREQE 459



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 43/263 (16%), Positives = 118/263 (44%), Gaps = 36/263 (13%)

Query: 38  EMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVH 97
           +M ++ +K+   E +++    +I E ++  ++  + + E     E ++++ + +  ++  
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE---EKMRRQEEMMWEKEEK 345

Query: 98  LKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLA 157
           ++E+  K  E  +I     + +E E  R+    QE + ++     +I E++ K R+    
Sbjct: 346 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405

Query: 158 FEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLC 217
            +EQ E +  Q + +W+    E + ++   +   +E++ ++EK ++   E ++ Q     
Sbjct: 406 MQEQEEKMGEQEEKMWE--QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ----- 458

Query: 218 GAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQR 277
                                     +E  ++ EE +     +  + + K Q+Q++K +R
Sbjct: 459 --------------------------EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492

Query: 278 LKEELEKHGMQVPAQAQSTQEEE 300
            +E++ +   ++  Q +  +E+E
Sbjct: 493 QEEKIREQEKKIREQEEKIREQE 515



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 62/295 (21%), Positives = 123/295 (41%), Gaps = 25/295 (8%)

Query: 31  QKIEDLMEMVQKLQKVGSLEPRVEVLINRIN-------EVQQA-------KKKANKDLGE 76
           QK E  M +      V  LE     LI+R++       E++QA       KKKA++ + E
Sbjct: 126 QKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEE 185

Query: 77  ARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKER 136
                +AL  EL         LKE  +K QE L+++     E +         L+  K  
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 245

Query: 137 ISALNLQIEEEK--NKQRQLRLAFEEQLEDLMGQHKDLWDF---HMPERLAKEICALDSS 191
           +    LQ E +    + + +    + Q+E+      +LW+       E++ ++   +   
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEE-----NELWNRLNQQQEEKMWRQEEKIQER 300

Query: 192 KEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAE 251
           +E++ ++E+ ++   E ++ Q   +   E      E +    +E    ++    E  K  
Sbjct: 301 EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 360

Query: 252 ELLAAAAQRHQ-QLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGD 305
           E      +  + + Q+K Q+Q+ K  R +E++ +   ++  Q +  QE+E   G+
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 38/200 (19%), Positives = 96/200 (48%), Gaps = 18/200 (9%)

Query: 4   RSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEV 63
           R    + E  A    + EK   Q+   ++ E++M+  ++ +K+G  E   E +  +  E+
Sbjct: 373 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQ--EQEEKMGEQE---EKMWEQEEEM 427

Query: 64  QQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEA 123
           Q+ ++K  +   + R   + ++++      EK+  +E + ++QE          E+E + 
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIREQ-----EEKIREQEEMMQEQEE------KMGEQEGKM 476

Query: 124 HRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAK 183
             +   +QE +E++     +I E++ K R+      EQ E +  Q + +W+    E++ +
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE--QEEKMCE 534

Query: 184 EICALDSSKEQLLKEEKLVK 203
           +   +   +E++ ++E+ ++
Sbjct: 535 QEEKMQEQEEKMRRQEEKMR 554



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 42/236 (17%), Positives = 102/236 (43%), Gaps = 28/236 (11%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKLQKVGSL---EPRVEVLINRINEVQQAKKKANKDLGEA 77
           EK   Q+   Q+ E + E  ++ ++   +   E ++     +I E ++  ++  + +GE 
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ 416

Query: 78  RTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERI 137
                  ++++     E    +E + +++E +R      +E+E +   +  M+QE +E++
Sbjct: 417 -------EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 469

Query: 138 SALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLK 197
                   E++ K  +     +EQ E +  Q          E++ ++   +   +E++ +
Sbjct: 470 G-------EQEGKMCEQEAKMQEQEEKMRRQE---------EKIREQEKKIREQEEKIRE 513

Query: 198 EEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQE--AAATVQLFQEEHRKAE 251
           +E++++   E +  Q   +C  E      E    R +E      V+L Q+E +  E
Sbjct: 514 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569


>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
          Length = 1219

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 75/301 (24%), Positives = 136/301 (45%), Gaps = 43/301 (14%)

Query: 21  EKAGGQDTSSQKIEDLMEMVQKL---------QKVGSLEPRVEVLINRINEVQQAKKKAN 71
           EK+   +  + KI +L+E  Q+          ++  SL+   E    R+   +Q K K  
Sbjct: 583 EKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVT 642

Query: 72  KDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQ 131
           ++L  A      LQ ++ +   ++  L+  L++  +   +LR     + ++   K + LQ
Sbjct: 643 EELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLR----GQLTKVQAKLSELQ 698

Query: 132 ECKERISALNLQIEEEKNKQRQLRL---AFEEQLEDLMGQHKDLWDFHMPERLAKEICAL 188
           E  E+  +   + + EK  ++QL L   + EE+L DL  + + L + ++ ER  K     
Sbjct: 699 ETSEQAQS---KFKSEKQNRKQLELKVTSLEEELTDLRVEKESL-EKNLSERKKK----- 749

Query: 189 DSSKEQLLKEEKL--VKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEE 246
            S++E+   EE++  ++ + ++   +L  L      ST         Q AA  + L Q E
Sbjct: 750 -SAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVST--------DQAAAEQLSLVQAE 800

Query: 247 -----HRKAEELLAAAAQRH-QQLQQKCQQQQQKRQRLKEELEK-HGMQVPAQAQSTQEE 299
                  K E LLA+A   H QQ Q+ C Q+   +Q+L +  EK   +Q    A + Q E
Sbjct: 801 LQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNE 860

Query: 300 E 300
           +
Sbjct: 861 Q 861



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 64/307 (20%), Positives = 123/307 (40%), Gaps = 30/307 (9%)

Query: 28  TSSQKIED--LMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKAN---KDLGEARTICE 82
           T+ QK E    M++ + L++   L  ++  +  +++E+Q+  ++A    K   + R   E
Sbjct: 660 TAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLE 719

Query: 83  ----ALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHT----MLQEC- 133
               +L++EL  L  EK  L++ LS++++     R   +E+  E  + +      L++  
Sbjct: 720 LKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLL 779

Query: 134 -KERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPE------------- 179
            K R+S      E+    Q +L+  +E + E L+   KD       E             
Sbjct: 780 KKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLV 839

Query: 180 RLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAAT 239
           +L ++  AL +    L K+ +     LE  K Q+  +  A    +      +     +  
Sbjct: 840 QLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLR 899

Query: 240 VQLFQEEHRKAEELLAAAAQRHQQ--LQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQ 297
            +   EE      +L       +   LQ   QQ+Q+K +   EE E+   + P +    Q
Sbjct: 900 REFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQ 959

Query: 298 EEEAGPG 304
              A  G
Sbjct: 960 SASASSG 966


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 52/269 (19%), Positives = 125/269 (46%), Gaps = 27/269 (10%)

Query: 19  RAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEAR 78
           R ++   ++   Q  E   +M ++ +++G  E +++    ++ E ++  +K  + +GE  
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240

Query: 79  TIC----EALQKELDSLHGEKVHLKEILS--KKQETLRILRLHCQEKESEAHRKHTMLQE 132
                  E +QK+ + +  ++  ++E     ++QE   + +    E+E +   +   ++E
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300

Query: 133 CKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSK 192
            +E++     Q+ E++ + R+      +Q E +  Q + +W+    E++ K+   +   +
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE--QKEQMWKQEEQMGEQE 358

Query: 193 EQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEE 252
           EQ+ K+E+ V+   E ++ Q             +E   +R QE     Q+ ++E +  E+
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQ-------------EEQ--MRKQEE----QMRKQEEQMGEQ 399

Query: 253 LLAAAAQRHQQLQQKCQQQQQKRQRLKEE 281
                 Q+ Q  +Q+ Q  +QK Q  K+E
Sbjct: 400 KEQMGEQKEQMREQEEQMGEQKEQMRKQE 428



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 39/256 (15%), Positives = 110/256 (42%), Gaps = 29/256 (11%)

Query: 62  EVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKES 121
           +V++ + +  +  G+ R      + ++    G+    +E + +++E ++       E+E 
Sbjct: 172 QVREQEGQVREQEGQVRE----QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227

Query: 122 EAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLW----DFHM 177
           +  ++   + E +E++     Q+++++ + R+      EQ E +  Q + +         
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ 287

Query: 178 PERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAA 237
            E+  ++   +   +EQ+ ++E+ ++   E ++ Q                     Q   
Sbjct: 288 EEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ-------------------EEQMGK 328

Query: 238 ATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQ--RLKEELEKHGMQVPAQAQS 295
              Q+++++ +  E+      Q  Q  +Q+ Q Q+Q+ Q  + +E++ K   Q+  Q + 
Sbjct: 329 QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ 388

Query: 296 TQEEEAGPGDVAPRPG 311
            +++E   G+   + G
Sbjct: 389 MRKQEEQMGEQKEQMG 404



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 33/172 (19%), Positives = 83/172 (48%), Gaps = 9/172 (5%)

Query: 117 QEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFH 176
           +E+E +   +   ++E + ++     Q+ E++ +  +      EQ E +  Q + + +  
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE-- 224

Query: 177 MPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEA 236
             E++ K+   +   +EQ+ K+E+ V+   E ++ Q   +   E      E   L+ +E 
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE- 283

Query: 237 AATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQ 288
               Q  QEE    +E      ++ +Q++++ +Q +++ ++++E+ E+ G Q
Sbjct: 284 ----QTEQEEQTGEQE--EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQ 329



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 46/280 (16%), Positives = 125/280 (44%), Gaps = 16/280 (5%)

Query: 28  TSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKE 87
           T+ +  E   E+ ++LQ V + +  +++ I  +    +  K      G+ R     ++++
Sbjct: 5   TNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQ 64

Query: 88  LDSLHGEKVHLKEILSKKQET---LRILRLHCQEKESEAHRKHTMLQECKERISALNLQI 144
              +  ++  ++E   + +E    +R      +E+E +   +   ++E + ++     Q+
Sbjct: 65  EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 124

Query: 145 EEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKA 204
            E++ + R+     E Q+ +  GQ ++        ++ ++   +   + Q+ ++E  V+ 
Sbjct: 125 REQEGQVREQ----EGQVREQEGQVRE-----QEGQVREQEGQVREQEGQVREQEGQVRE 175

Query: 205 TLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAAT----VQLFQEEHRKAEELLAAAAQR 260
               V+ Q   +   EG     EG     +E        +Q  +E+  + EE +    ++
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQ 235

Query: 261 HQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
             + +++ Q+Q+++ Q+ +E++ K   Q+  Q +  +E+E
Sbjct: 236 MGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQE 275



 Score = 35.0 bits (79), Expect = 0.088
 Identities = 31/184 (16%), Positives = 80/184 (43%), Gaps = 33/184 (17%)

Query: 117 QEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFH 176
           +E+E +   +   ++E + ++     Q+ E++ + R+      EQ E  MG+ ++     
Sbjct: 153 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQ-EGQMGEQEEQMG-E 210

Query: 177 MPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEA 236
             E++ K+   +   +EQ+ K+E+ +    E V+ Q                        
Sbjct: 211 QEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ------------------------ 246

Query: 237 AATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQST 296
                  +E+ +K EE +    ++ ++ +++ ++Q+++  + KE+ E+       + Q  
Sbjct: 247 -------EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299

Query: 297 QEEE 300
           ++EE
Sbjct: 300 EQEE 303



 Score = 32.0 bits (71), Expect = 0.75
 Identities = 28/145 (19%), Positives = 68/145 (46%), Gaps = 7/145 (4%)

Query: 19  RAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEAR 78
           R ++   ++   Q  E   +M ++ +++G  E ++     ++ E ++   K  + +GE  
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358

Query: 79  TICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERIS 138
              E +QK+ + +  ++    E + K++E +R      +++E +   +   + E KE++ 
Sbjct: 359 ---EQMQKQEEQVRKQE----EQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411

Query: 139 ALNLQIEEEKNKQRQLRLAFEEQLE 163
               Q+ E+K + R+      EQ E
Sbjct: 412 EQEEQMGEQKEQMRKQEEHMGEQKE 436


>gi|239745111 PREDICTED: Golgin subfamily A member 8-like protein 3
           isoform 1 [Homo sapiens]
          Length = 632

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 66/312 (21%), Positives = 131/312 (41%), Gaps = 53/312 (16%)

Query: 28  TSSQKIEDLMEMVQKLQKV-GSLEPRVEVLINRINEVQQAKK----------KANKDLGE 76
           TSS  ++DL    Q+   V  S    +  L N I  ++Q KK          KAN    +
Sbjct: 67  TSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQK 126

Query: 77  ARTICEA----LQKELDSLHGEKVHLKEIL---SKKQETLRILRLHCQEKESEAH----- 124
           A+ + E     L  + + L+ +  H+K  L    +K + L +   H  +++ E       
Sbjct: 127 AKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSN 186

Query: 125 ------------------RKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLM 166
                             R    L++     + L +Q+ + K   +Q++L  +E  E L 
Sbjct: 187 VMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQFKESFQQVQLERDEYSEHLK 246

Query: 167 GQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLD 226
           G+ +  W   M  ++++EIC L   K+Q ++  + ++ +L  +K+Q+      E P+   
Sbjct: 247 GE-RARWQQRM-RKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPS 304

Query: 227 EGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHG 286
           E            +Q  ++E  +    L A  + +Q++    Q+Q+++ +  +E L K  
Sbjct: 305 E----------VELQHLRKELERVAGELQAQVKNNQRISLLNQRQEERIREQEERLRKQE 354

Query: 287 MQVPAQAQSTQE 298
            ++  Q +S Q+
Sbjct: 355 ERIQEQHKSLQQ 366



 Score = 28.5 bits (62), Expect = 8.2
 Identities = 27/131 (20%), Positives = 57/131 (43%), Gaps = 8/131 (6%)

Query: 38  EMVQKLQKVGSLEPRVEVLINRINEVQQAKKKA---NKDLGEARTICEALQKELDSLHGE 94
           E  Q +++V  LE  +  L N++ E    +  A     +L   R   E +  EL +    
Sbjct: 269 EKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKN 328

Query: 95  KVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL 154
              +  +  +++E +R      +++E     +H  LQ+  +  S     + +E N + + 
Sbjct: 329 NQRISLLNQRQEERIREQEERLRKQEERIQEQHKSLQQLAKPQS-----VFKEPNNENKN 383

Query: 155 RLAFEEQLEDL 165
            L  E+Q+++L
Sbjct: 384 ALQLEQQVKEL 394


>gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 1 isoform 3 [Homo sapiens]
          Length = 601

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 74/318 (23%), Positives = 133/318 (41%), Gaps = 45/318 (14%)

Query: 31  QKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDS 90
           Q +  L E  +   +    E  +EV I R+N +Q  K K N DL   +      ++E   
Sbjct: 113 QVVHQLEEEKKANNEKQKAERELEVQIQRLN-IQ--KGKLNTDLYHTKRSLRYFEEESKD 169

Query: 91  LHGEKVHLKEILSKKQETLRILRL--HCQEKESEAH------RKHTMLQECKERISALNL 142
           L    V L+  L +K E  R L      Q+K++E        R    L++     + L  
Sbjct: 170 L---AVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTEWKLEQSMREQALLKA 226

Query: 143 QIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLV 202
           Q+ + K   ++++L  +E  E L G+ +  W   M  ++++E+C+L   K+      + +
Sbjct: 227 QLTQLKESLKEVQLERDEYAEHLKGE-RARWQQRM-RKMSQEVCSLKKEKKHDKYRVETL 284

Query: 203 KATLEDVKHQLCSLCGAEGPSTLDEG----LFLRSQEAAATVQLFQEEHRKAEELLAAAA 258
           + +L  +K+Q+      E P+   E     L    +  A  +Q   E +++   L     
Sbjct: 285 ERSLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEYNQRISLLNEGQK 344

Query: 259 QRHQQLQQKCQQQQQKRQRL------------------------KEELEKHGMQVPAQAQ 294
           +R ++ Q++  +Q+++ Q+L                        KE  EK G ++     
Sbjct: 345 ERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGKRLAHLVA 404

Query: 295 STQEE-EAGPGDVAPRPG 311
           S Q+E EA  G  AP PG
Sbjct: 405 SAQKEPEAARGPGAPGPG 422


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 74/314 (23%), Positives = 137/314 (43%), Gaps = 52/314 (16%)

Query: 31   QKIEDL-MEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELD 89
            Q++E+  M++    QKV SLE  ++ + ++ ++ + +  K  K L +     +  ++ELD
Sbjct: 1500 QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELD 1559

Query: 90   SLHGEKVHLKEI-LSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEE- 147
               G    L++  L  + E  R+ + H +E ES         Q C++++  + +Q+EEE 
Sbjct: 1560 EQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 1619

Query: 148  KNKQRQLR--LAFEEQLEDLMGQHKDLWDFHMPERLAK---------------------- 183
            ++KQ+ LR     E +L  L  Q  +  DF   +RL K                      
Sbjct: 1620 EDKQKVLREKRELEGKLATLSDQ-VNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678

Query: 184  -----EICALDSSKEQ-------LLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFL 231
                 EI  L +  E+        +K  K ++  +ED+  Q+  +  A+  + L+E L  
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDI--AKAKTALEEQLSR 1736

Query: 232  RSQEAAATVQLFQEEHRKAEELL----AAAAQRHQ------QLQQKCQQQQQKRQRLKEE 281
              +E        +E+     EL+    AA AQ  +       LQ + ++  +++Q L+E+
Sbjct: 1737 LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEK 1796

Query: 282  LEKHGMQVPAQAQS 295
            L+    QV    QS
Sbjct: 1797 LQALQSQVEFLEQS 1810



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 57/231 (24%), Positives = 108/231 (46%), Gaps = 31/231 (13%)

Query: 21   EKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTI 80
            EK   Q+   +  ED+ E+++K +   +   R    + +IN++Q   ++ANK+  E +  
Sbjct: 1740 EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD---LAQINDLQAQLEEANKEKQELQEK 1796

Query: 81   CEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKE----- 135
             +ALQ +++ L    V  K ++S+++  +R L    + + ++  R  ++    KE     
Sbjct: 1797 LQALQSQVEFLEQSMVD-KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKL 1855

Query: 136  ------RISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQ--HKDLWDFHMPERLAKEICA 187
                  RI+A N + E+ K  QRQLR   EE     MG+   K+         L  ++ +
Sbjct: 1856 TEERDQRIAAENREKEQNKRLQRQLRDTKEE-----MGELARKEAEASRKKHELEMDLES 1910

Query: 188  LDSSKEQLLKEEKL-------VKATLED--VKHQLCSLCGAEGPSTLDEGL 229
            L+++ + L  + KL       ++A +ED     +   L  +EG S +D  L
Sbjct: 1911 LEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSEL 1961



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 42/212 (19%), Positives = 85/212 (40%), Gaps = 17/212 (8%)

Query: 99   KEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQL---- 154
            +E +  K E ++ LR   ++ E E +         + RIS L  ++ +E+N         
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1312

Query: 155  ------RLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLED 208
                  RL  E+++++L  Q+  L       +   E+  ++  + +L++  ++     +D
Sbjct: 1313 DAETAERLRAEKEMKELQTQYDAL-------KKQMEVMEMEVMEARLIRAAEINGEVDDD 1365

Query: 209  VKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKC 268
                   L        +D       QE    +++ Q+  R+ E  L       ++ Q+  
Sbjct: 1366 DAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRAL 1425

Query: 269  QQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE 300
            QQ ++K QRL  EL+   + +  Q     E E
Sbjct: 1426 QQLKKKCQRLTAELQDTKLHLEGQQVRNHELE 1457



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 55/294 (18%), Positives = 127/294 (43%), Gaps = 33/294 (11%)

Query: 32   KIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSL 91
            K E++ ++  KL+K    + R E+ +N  + ++    +   +L + R   E+  + LD+ 
Sbjct: 1259 KDEEIQQLRSKLEKAE--KERNELRLNS-DRLESRISELTSELTDERNTGESASQLLDAE 1315

Query: 92   HGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQ 151
              E++  ++ + + Q     L+   +  E E      +      R + +N +++++ +  
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI------RAAEINGEVDDD-DAG 1368

Query: 152  RQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKH 211
             + RL +E  + ++     D     + +    ++     +K QL +    ++A  E+ + 
Sbjct: 1369 GEWRLKYERAVREV-----DFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQR 1423

Query: 212  QLCSL---CGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQ-QK 267
             L  L   C        D  L L  Q+     +L +++ R   EL    +Q H++ Q +K
Sbjct: 1424 ALQQLKKKCQRLTAELQDTKLHLEGQQVR-NHELEKKQRRFDSEL----SQAHEEAQREK 1478

Query: 268  CQQQQQKRQR---------LKEELEKHGMQVPAQAQSTQEEEAGPGDVAPRPGR 312
             Q+++ +R++         LK++LE+  M +    Q     EA   D++ +  +
Sbjct: 1479 LQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,480,405
Number of Sequences: 37866
Number of extensions: 597127
Number of successful extensions: 10835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 765
Number of HSP's that attempted gapping in prelim test: 4535
Number of HSP's gapped (non-prelim): 3857
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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