Search of human proteins with 218563758

Search of human proteins with 218563758

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...  1094   0.0  
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...  1094   0.0  
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...  1068   0.0  
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   597   e-171
gi|197276623 solute carrier family 6 (neurotransmitter transport...   590   e-168
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   590   e-168
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   590   e-168
gi|171184408 solute carrier family 6 (neurotransmitter transport...   577   e-165
gi|171184406 solute carrier family 6 (neurotransmitter transport...   577   e-165
gi|171184404 solute carrier family 6 (neurotransmitter transport...   577   e-165
gi|188528618 solute carrier family 6 (neurotransmitter transport...   533   e-151
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   423   e-118
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   423   e-118
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   423   e-118
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         423   e-118
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   417   e-117
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            414   e-115
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   407   e-113
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            395   e-110
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   364   e-101
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        300   2e-81
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   290   2e-78
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         284   1e-76
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   231   2e-60
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         205   7e-53
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   200   2e-51
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   200   2e-51
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         164   2e-40
gi|197276625 solute carrier family 6 (neurotransmitter transport...   100   2e-21
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   100   3e-21

>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score = 1094 bits (2830), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60
           MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT
Sbjct: 116 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 175

Query: 61  WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120
           WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV
Sbjct: 176 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235

Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180
           TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP
Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295

Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240
           DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA
Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 355

Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300
           GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL
Sbjct: 356 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 415

Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360
           DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY
Sbjct: 416 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 475

Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420
           YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF
Sbjct: 476 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 535

Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480
           IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT
Sbjct: 536 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 595

Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520
           QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 596 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 635


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score = 1094 bits (2830), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60
           MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT
Sbjct: 1   MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60

Query: 61  WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120
           WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV
Sbjct: 61  WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120

Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180
           TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP
Sbjct: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180

Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240
           DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA
Sbjct: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240

Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300
           GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL
Sbjct: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300

Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360
           DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY
Sbjct: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360

Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420
           YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF
Sbjct: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420

Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480
           IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT
Sbjct: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480

Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520
           QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score = 1068 bits (2761), Expect = 0.0
 Identities = 509/520 (97%), Positives = 510/520 (98%), Gaps = 10/520 (1%)

Query: 1   MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60
           MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT
Sbjct: 116 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 175

Query: 61  WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120
           WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV
Sbjct: 176 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235

Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180
           TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP
Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295

Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240
           DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY          +GTSFFA
Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NGTSFFA 345

Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300
           GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL
Sbjct: 346 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 405

Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360
           DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY
Sbjct: 406 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465

Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420
           YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF
Sbjct: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525

Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480
           IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT
Sbjct: 526 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 585

Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520
           QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 586 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 625


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  597 bits (1540), Expect = e-171
 Identities = 274/480 (57%), Positives = 356/480 (74%), Gaps = 7/480 (1%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G I  W  +CPLF+G+GYA+ VI  + N YYI++LAW  +YL   FTT LPWATCGH WN
Sbjct: 117 GGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWN 176

Query: 63  TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 122
           T +CVE  +       +++N +   L +  SPV+EFWE++VL +S G+E  G L WE+ L
Sbjct: 177 TENCVEFQK------LNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELAL 230

Query: 123 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDW 182
           CLLA W + YFC+WKG KSTGK+VY TATFPY++L++LL+RGV LPGA +GI +YL PD 
Sbjct: 231 CLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDL 290

Query: 183 SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGF 242
           S+L  PQVW+DAGTQIFFSYAI LG LTALGSYN +NNNCY+D I+L  +NSGTSF AGF
Sbjct: 291 SRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGF 350

Query: 243 VVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 302
            +FS+LGFMA EQGV I++VAESGPGLAFIAYP+AVT+MP++PLWA LFF ML+ LGLDS
Sbjct: 351 AIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDS 410

Query: 303 QFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 362
           QFV VE  +T ++D+ P  +   ++RE+ +     + + + L M+T+GGMY+FQLFD Y+
Sbjct: 411 QFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYA 470

Query: 363 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422
           ASG  LL+ A +EC+ + WVYG++RF D+I  MIGYRP   +KWCW   TP +C GIFIF
Sbjct: 471 ASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIF 530

Query: 423 NVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482
            ++ Y+PL YNN Y YP WG  +GW  ALSSMLC+PL +   + + +GT+ E+ Q LT P
Sbjct: 531 FLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP 590


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  590 bits (1521), Expect = e-168
 Identities = 282/483 (58%), Positives = 356/483 (73%), Gaps = 12/483 (2%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G I  W  ICPLF G+GYAS+VIV   N YYI++LAW  YYL +SF   LPWA C H+WN
Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167

Query: 63  TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
           TP C+E    ++ +     S  N T        SPVIEFWE  VL LS G++ PG+L W+
Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWERNVLSLSPGIDHPGSLKWD 219

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           + LCLL  W++ +FC+WKGV+STGK+VYFTATFP+ +L+VLLVRG+ LPGA  GI +YL 
Sbjct: 220 LALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLY 279

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           PD ++L  PQVWIDAGTQIFFSYAI LGA+T+LGSYN++  N Y+D ++L  +NSGTSF 
Sbjct: 280 PDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFV 339

Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299
           +GF +FSILGFMA EQGV I+ VAESGPGLAFIAYP+AVT+MP+   W+ LFF MLLLLG
Sbjct: 340 SGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLG 399

Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359
           LDSQFV VEG IT L+DL P+     ++REI +A  C++ +++ L+MVT+GGMYVFQLFD
Sbjct: 400 LDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFD 459

Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
           YY+ASG  LLW AF+EC V+AW+YG D   D I  MIGYRP PWMK+ W+  TP++C+G 
Sbjct: 460 YYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGC 519

Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479
           FIF++V Y PL YN TYVYP W   +GW+ ALSSMLCVPL ++  L + +G    R ++L
Sbjct: 520 FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYL 579

Query: 480 TQP 482
             P
Sbjct: 580 LTP 582


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  590 bits (1521), Expect = e-168
 Identities = 282/483 (58%), Positives = 356/483 (73%), Gaps = 12/483 (2%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G I  W  ICPLF G+GYAS+VIV   N YYI++LAW  YYL +SF   LPWA C H+WN
Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167

Query: 63  TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
           TP C+E    ++ +     S  N T        SPVIEFWE  VL LS G++ PG+L W+
Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWERNVLSLSPGIDHPGSLKWD 219

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           + LCLL  W++ +FC+WKGV+STGK+VYFTATFP+ +L+VLLVRG+ LPGA  GI +YL 
Sbjct: 220 LALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLY 279

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           PD ++L  PQVWIDAGTQIFFSYAI LGA+T+LGSYN++  N Y+D ++L  +NSGTSF 
Sbjct: 280 PDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFV 339

Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299
           +GF +FSILGFMA EQGV I+ VAESGPGLAFIAYP+AVT+MP+   W+ LFF MLLLLG
Sbjct: 340 SGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLG 399

Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359
           LDSQFV VEG IT L+DL P+     ++REI +A  C++ +++ L+MVT+GGMYVFQLFD
Sbjct: 400 LDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFD 459

Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
           YY+ASG  LLW AF+EC V+AW+YG D   D I  MIGYRP PWMK+ W+  TP++C+G 
Sbjct: 460 YYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGC 519

Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479
           FIF++V Y PL YN TYVYP W   +GW+ ALSSMLCVPL ++  L + +G    R ++L
Sbjct: 520 FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYL 579

Query: 480 TQP 482
             P
Sbjct: 580 LTP 582


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  590 bits (1520), Expect = e-168
 Identities = 283/507 (55%), Positives = 356/507 (70%), Gaps = 9/507 (1%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G +  W  ICP+F+G+GYAS +IV   N YYI+VLAW  +YL  SFT  LPW  C H WN
Sbjct: 99  GGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWN 158

Query: 63  TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 122
           T  C+E  +     N +  N T        SPVIEFWE +VL++S G++  GAL WE+ L
Sbjct: 159 TEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGALRWELAL 210

Query: 123 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDW 182
           CLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA  GI +YL P+ 
Sbjct: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270

Query: 183 SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGF 242
           ++L  PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY+D I L  +NSGTSF AGF
Sbjct: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330

Query: 243 VVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 302
            +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA  FFFM++LLGLDS
Sbjct: 331 AIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDS 390

Query: 303 QFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 362
           QFV VE  +T L+D+ P  +  + +RE+ +     + F++ L M+T+GGMYVFQLFDYY+
Sbjct: 391 QFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYA 450

Query: 363 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422
           ASG  LL+ A +E + VAWVYGA RF D+I  MIGYRP P +K+CW F TP VC   F+F
Sbjct: 451 ASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLF 510

Query: 423 NVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482
           +++ Y PL YN  Y YPWWG+A+GW  ALSSM+C+P   L  L   KG   ER + L  P
Sbjct: 511 SLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCP 570

Query: 483 IWGLHHLEYRAQDADVRGLTTLTPVSE 509
              L         A     T+L  ++E
Sbjct: 571 AEDLPQRNPAGPSAPATPRTSLLRLTE 597


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  577 bits (1487), Expect = e-165
 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ LPW TC + WN
Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162

Query: 63  TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121
           T  C +   H      +   N T        SPV+EFWE +VL ++ G+   G+L WE+ 
Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181
           LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA  GIIYYLKPD
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241
             +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCYKD I L  +NS TSF AG
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301
           FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD
Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394

Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361
           SQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GGMY+FQLFDYY
Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454

Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421
           ++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F TP +C+  F+
Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514

Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481
           F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G   +R + L  
Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574

Query: 482 P 482
           P
Sbjct: 575 P 575


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  577 bits (1487), Expect = e-165
 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ LPW TC + WN
Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162

Query: 63  TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121
           T  C +   H      +   N T        SPV+EFWE +VL ++ G+   G+L WE+ 
Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181
           LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA  GIIYYLKPD
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241
             +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCYKD I L  +NS TSF AG
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301
           FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD
Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394

Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361
           SQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GGMY+FQLFDYY
Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454

Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421
           ++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F TP +C+  F+
Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514

Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481
           F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G   +R + L  
Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574

Query: 482 P 482
           P
Sbjct: 575 P 575


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  577 bits (1487), Expect = e-165
 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ LPW TC + WN
Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162

Query: 63  TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121
           T  C +   H      +   N T        SPV+EFWE +VL ++ G+   G+L WE+ 
Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214

Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181
           LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA  GIIYYLKPD
Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274

Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241
             +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCYKD I L  +NS TSF AG
Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334

Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301
           FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD
Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394

Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361
           SQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GGMY+FQLFDYY
Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454

Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421
           ++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F TP +C+  F+
Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514

Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481
           F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G   +R + L  
Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574

Query: 482 P 482
           P
Sbjct: 575 P 575


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  533 bits (1373), Expect = e-151
 Identities = 248/479 (51%), Positives = 337/479 (70%), Gaps = 16/479 (3%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G + VW + P+FKG+G A+ V+ F+ N YYI++++W  YYL  SFTTTLPW  C + WNT
Sbjct: 111 GGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNT 170

Query: 64  PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLC 123
             C         +N S+ N T     +  S V+EFWE  + +++ GL+ PG + W + + 
Sbjct: 171 DRCF--------SNYSMVNTT-----NMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAIT 217

Query: 124 LLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWS 183
           L   W+LVYFC+WKGV  TGK+VYF+AT+PY++L++L  RGV LPGA +GI++Y+ P++ 
Sbjct: 218 LAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFR 277

Query: 184 KLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFV 243
           KL   +VW+DA TQIFFSY +GLG+L ALGSYN F+NN Y+D+II+  INS TS FAGFV
Sbjct: 278 KLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337

Query: 244 VFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQ 303
           +FSI+GFMA      I+ VA SGPGLAF+AYP AVT +P++PLWA LFF MLL+LG+DSQ
Sbjct: 338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQ 397

Query: 304 FVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSA 363
           F  VEGFIT L+D  P     R +RE+ +A  C + ++I LS +T GG+YVF+LFDYYSA
Sbjct: 398 FCTVEGFITALVDEYPR--LLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA 455

Query: 364 SGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFN 423
           SG +LL+  F+ECV ++W YG +RF D+I  M+G RPC W K CWSFFTP++  G+FIF+
Sbjct: 456 SGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFS 515

Query: 424 VVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482
            V   PL   N YV+P WG+ +GW  ALSSM+ +P ++    L  KG++ +R Q + QP
Sbjct: 516 AVQMTPLTMGN-YVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQP 573


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  423 bits (1087), Expect = e-118
 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT
Sbjct: 94  GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 153

Query: 64  PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116
            DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +
Sbjct: 154 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 213

Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176
              +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y
Sbjct: 214 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 273

Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236
           YL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY+D++I+++ N  T
Sbjct: 274 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 333

Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296
           S +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+
Sbjct: 334 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 393

Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356
           LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   
Sbjct: 394 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 452

Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416
           L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P + 
Sbjct: 453 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 511

Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475
             I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R
Sbjct: 512 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 570

Query: 476 WQHLTQPI--WGLHHLEYR 492
            ++ T+P   WG   LE+R
Sbjct: 571 LKNATKPSRDWGPALLEHR 589


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  423 bits (1087), Expect = e-118
 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT
Sbjct: 167 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 226

Query: 64  PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116
            DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +
Sbjct: 227 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 286

Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176
              +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y
Sbjct: 287 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 346

Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236
           YL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY+D++I+++ N  T
Sbjct: 347 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 406

Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296
           S +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+
Sbjct: 407 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 466

Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356
           LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   
Sbjct: 467 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 525

Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416
           L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P + 
Sbjct: 526 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 584

Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475
             I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R
Sbjct: 585 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 643

Query: 476 WQHLTQPI--WGLHHLEYR 492
            ++ T+P   WG   LE+R
Sbjct: 644 LKNATKPSRDWGPALLEHR 662


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  423 bits (1087), Expect = e-118
 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT
Sbjct: 113 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 172

Query: 64  PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116
            DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +
Sbjct: 173 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 232

Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176
              +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y
Sbjct: 233 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 292

Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236
           YL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY+D++I+++ N  T
Sbjct: 293 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 352

Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296
           S +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+
Sbjct: 353 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412

Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356
           LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   
Sbjct: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 471

Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416
           L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P + 
Sbjct: 472 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 530

Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475
             I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R
Sbjct: 531 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 589

Query: 476 WQHLTQPI--WGLHHLEYR 492
            ++ T+P   WG   LE+R
Sbjct: 590 LKNATKPSRDWGPALLEHR 608


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  423 bits (1087), Expect = e-118
 Identities = 215/486 (44%), Positives = 302/486 (62%), Gaps = 13/486 (2%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G + VW I PLFKG G A ++IV     YY M++A+  +YL  S T+ LPW  CG+ WNT
Sbjct: 104 GPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNT 163

Query: 64  PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPGALNWEVT 121
             C+E    +D   A   NLTC       SP  E+W   VL + G  G+  PG + W + 
Sbjct: 164 ELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLC 218

Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181
           LCLL  WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA  GI +YL P 
Sbjct: 219 LCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQ 278

Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241
           +  L S +VWI+A  QIF+S  +G G L    SYN F+ N Y+D  I+ L N+ TS  AG
Sbjct: 279 FHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAG 338

Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301
           F +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFMLL LGLD
Sbjct: 339 FAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLD 398

Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361
           SQF  +E  +T + D  P  YY R ++ +   L C   +++ L + TDGGMY   L D Y
Sbjct: 399 SQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDY 456

Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421
           SAS   L+      C+ V  VYG  RF  DI  M+G++P  + + CW F +P   + + +
Sbjct: 457 SAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515

Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481
           +++V Y+P  Y  +Y +P W E +G    L S L +P  +L  +LR +G++ ER Q  ++
Sbjct: 516 YSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASR 574

Query: 482 PI--WG 485
           P   WG
Sbjct: 575 PAMDWG 580


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  417 bits (1073), Expect = e-117
 Identities = 214/532 (40%), Positives = 308/532 (57%), Gaps = 32/532 (6%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G ++VW   P  +G G A ++I      YY +++ +  +YL  SF + LPW +C + WNT
Sbjct: 258 GPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNT 317

Query: 64  PDC------------------VEIFRHEDCA----NASLANLTCDQLADRRSPVIEFWEN 101
           P+C                  ++I     C     N ++ N T        S   E+++ 
Sbjct: 318 PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKY 377

Query: 102 KVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 161
            VL++S G+E PG + W + LCL   WV+VY  + KG+K++GK+VYFTATFPYVVLV+LL
Sbjct: 378 FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILL 437

Query: 162 VRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNN 221
           +RGV LPGA  GI Y++ P W KL    VW DA TQIFFS +   G L  L SYN+F+NN
Sbjct: 438 IRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNN 497

Query: 222 CYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLM 281
           CY+D +I+   NS TS FAGFV+FS++GFMA E+ V+I  VA+ GPG+AF+ YP A+T +
Sbjct: 498 CYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRL 557

Query: 282 PVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFV 341
           P++P WA +FF MLL LGLD+ F  +E  +T + D  P   Y R  + +    CC   F+
Sbjct: 558 PLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLGCCICFFI 615

Query: 342 IDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPC 401
           +   M+T GG+Y+FQL D Y+AS   L+  A +E V +++VYG  RF +DI  MIG++P 
Sbjct: 616 MGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPN 674

Query: 402 PWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHL 461
            + K CW+F TP +   I  F+   +EP+ Y  +Y YP W   +GW     S++ +P+  
Sbjct: 675 IFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSVIWIPIMF 733

Query: 462 LGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 511
           +  +  A G   ER + +   QP WG     + AQ    R    + P+  SS
Sbjct: 734 VIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  414 bits (1063), Expect = e-115
 Identities = 210/490 (42%), Positives = 298/490 (60%), Gaps = 12/490 (2%)

Query: 2   KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTW 61
           + G+  VW ICP FKG+GYA ++I  Y   YY +++AW  YYL  SFT  LPW  CGHTW
Sbjct: 121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW 180

Query: 62  NTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWE 119
           N+P+C +        N S+          + +P  EF+E  VL L  S G+   G   W+
Sbjct: 181 NSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQ 236

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           + LCL+   +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +GI  YL 
Sbjct: 237 LLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLH 296

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
            D+ +L    VWIDA TQIFFS   G G L A  SYN+F+NNCY+DA++ + IN  TSF 
Sbjct: 297 IDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFV 356

Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299
           +GF +FSILG+MA E  V+I  VA  G GL FI YP A++ +  +  WA +FF MLL LG
Sbjct: 357 SGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALG 416

Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359
           LDS   G+E  ITGL D        +  R++         F++ L  +T GG+YV  L D
Sbjct: 417 LDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLD 473

Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
            + A+GT++L+    E + V+W YG DRF +DI  M+G+RP  + + CW F +P   + +
Sbjct: 474 TF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532

Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479
            + +++ ++PL Y++ Y++P W   +GW  ALSSM+ VP++++   L  +G++ ER  + 
Sbjct: 533 VVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYG 591

Query: 480 TQPIWGLHHL 489
             P    HHL
Sbjct: 592 ITP-ENEHHL 600


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  407 bits (1045), Expect = e-113
 Identities = 204/483 (42%), Positives = 290/483 (60%), Gaps = 12/483 (2%)

Query: 2   KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTW 61
           + G+  VW ICP+ KG+G+  ++I  Y   +Y +++AW  +YL  SFTT LPW  C ++W
Sbjct: 125 REGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSW 184

Query: 62  NTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWE 119
           N+P+C +    +   ++S  N T        +P  E++E  VL L  S G++  G   W+
Sbjct: 185 NSPNCSDAHPGDSSGDSSGLNDTFGT-----TPAAEYFERGVLHLHQSHGIDDLGPPRWQ 239

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           +T CL+   VL+YF +WKGVK++GK+V+ TAT PYVVL  LL+RGV LPGA+DGI  YL 
Sbjct: 240 LTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
            D+ +L    VWIDA TQ+ FS  +G G L A  SYN+F NNCY+DAI+   INS TSF 
Sbjct: 300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFS 359

Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299
           +GFVVFS LG+MA +  V I  VA+ GPGL FI YP A+  +P++  WA +FF MLL LG
Sbjct: 360 SGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLG 419

Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359
           +DS   G+E  ITGL+D     +     RE+         F++ L  VT+GG+YVF L D
Sbjct: 420 IDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLATFLLSLFCVTNGGIYVFTLLD 476

Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
           ++ A+GT++L+    E + VAW YG  +F DDI  M G RP  + + CW   +P   + +
Sbjct: 477 HF-AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFV 535

Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479
            + ++V + P  Y   Y++P W  A+GW  A SSM  VP++         G+  E+  + 
Sbjct: 536 VVVSIVTFRPPHY-GAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYA 594

Query: 480 TQP 482
             P
Sbjct: 595 IAP 597


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  395 bits (1015), Expect = e-110
 Identities = 201/476 (42%), Positives = 292/476 (61%), Gaps = 18/476 (3%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G I++W  ICP+FKG+GYA  +I FY  +YY  ++AW  YYL+ SFT  LPW +C ++WN
Sbjct: 146 GCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWN 205

Query: 63  TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWEV 120
           T +C   F  +        N+T        SP  EF+   VL++  S GL+  G ++W++
Sbjct: 206 TGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255

Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180
            LC++  + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG  LPGA  G+++YLKP
Sbjct: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315

Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240
           +W KL    VWIDA  QIFFS   G G L A  SYN+FNNNCY+DA++ +++N  TSF +
Sbjct: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVS 375

Query: 241 GFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299
           GFV+F++LG+MA  +   +S+VA ++GP L FI Y  A+  MP +  +A +FF ML+ LG
Sbjct: 376 GFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLG 435

Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359
           LDS F G+EG IT +LD  P  + +  +RE  V      CF   L  +T GG YV +L +
Sbjct: 436 LDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493

Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
            Y A+G  +L  A  E V V+W YG  +F  D+  M+G+ P  + + CW   +PL  + I
Sbjct: 494 EY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552

Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 475
            I + +   P +    Y YP+W   +G+    SS +C+P ++   L+   GT  ER
Sbjct: 553 -ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  364 bits (935), Expect = e-101
 Identities = 199/522 (38%), Positives = 301/522 (57%), Gaps = 39/522 (7%)

Query: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63
           G ++VW I PLF+G+G   ++I  +   YY +++A+  YY+  SF + LPW  C  +W+ 
Sbjct: 103 GPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCS-SWSD 161

Query: 64  PDCVE--IFRHEDCANAS---------------LANLTCDQLAD----RRSPVIEFWENK 102
            +C    I  H + +  +               + N TC   ++     + P  ++W   
Sbjct: 162 KNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKV 221

Query: 103 VLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLV 162
            L+ S G+   G + W + LCLL  W++V   ++KG+KS+GK+VYFTA FPYVVL++LLV
Sbjct: 222 ALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLV 281

Query: 163 RGVLLPGALDGIIYYL--KPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNN 220
           RG  L GA  GI YY+  + +++KL   +VW DA TQIF+S ++  G L AL SYN+F N
Sbjct: 282 RGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKN 341

Query: 221 NCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTL 280
           NC+ DAI++ L N  TS FAGF +FSILG MA   G  +S+V +SG  LAFIAYP A+  
Sbjct: 342 NCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQ 401

Query: 281 MPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVAL---CCA 337
           +P  P W+ LFFFMLL LGLDSQF  +E   T + DL P     +  +++ V +   CC 
Sbjct: 402 LPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFP-----KVMKKMRVPITLGCCL 456

Query: 338 LCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIG 397
           + F++ L  VT  G+Y   L D++ A G  +L  A  E V + W+YG +RF++D   MIG
Sbjct: 457 VLFLLGLVCVTQAGIYWVHLIDHFCA-GWGILIAAILELVGIIWIYGGNRFIEDTEMMIG 515

Query: 398 -YRPCPWMKW--CWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSM 454
             R   W+ W  CW   TP++ + IFI+++V +    Y     YP WG A+GW   +  +
Sbjct: 516 AKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNY-GAIPYPDWGVALGWCMIVFCI 574

Query: 455 LCVPLHLLGCLLRAKGTMAERWQHLTQPI--WGLHHLEYRAQ 494
           + +P+  +  +++AKG + +R     +P   WG +  ++R +
Sbjct: 575 IWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGE 616


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  300 bits (768), Expect = 2e-81
 Identities = 188/545 (34%), Positives = 269/545 (49%), Gaps = 95/545 (17%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           ++ GS+ VW  I P   G+G   + + F  + YY  ++AW  +YL+ SF   LPW++C  
Sbjct: 82  LRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPP 141

Query: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
             N    VE     +C  +S  +               FW  + L ++  +   G++ W 
Sbjct: 142 DLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGSIQWW 182

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA  G+IY   
Sbjct: 183 LLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFT 242

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           P+   L +P+VW+DA TQIFFS ++  G   A  SYN   N+C KDA+++AL+N  TS +
Sbjct: 243 PNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLY 302

Query: 240 AGFVVFSILGFMAAEQGVHI------------------------------------SKVA 263
           A   VFS+LGF A     H                                      +VA
Sbjct: 303 ASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVA 362

Query: 264 E----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGV 307
           +                SGPGLAF+ +      MP AP+WA LFF ML  LGL + F  V
Sbjct: 363 QLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTV 422

Query: 308 EGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365
           E  IT LLD  +LP        +E    L C +CF+         G Y  ++FD ++AS 
Sbjct: 423 EAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAAS- 477

Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425
             LL  AF E V V +VYG  RF DDIA M G RP P+ +  W   +PL+ + IF+  ++
Sbjct: 478 PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFVAYII 536

Query: 426 --YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL-RAKG 470
             +++PL Y   N  Y         +YP W  A     +L  +L VP+  L  LL R + 
Sbjct: 537 LLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRR 596

Query: 471 TMAER 475
           T  +R
Sbjct: 597 TWRDR 601


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  290 bits (743), Expect = 2e-78
 Identities = 184/539 (34%), Positives = 258/539 (47%), Gaps = 95/539 (17%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+ C  
Sbjct: 69  MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128

Query: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
             N          E+C  AS                  FW  K L +S  L+  G + WE
Sbjct: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
             LCLL  W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++Y   
Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFT 229

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           P   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC K AII++LINS TS F
Sbjct: 230 PKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 289

Query: 240 AGFVVFSILGFMAA--------------------EQG----------------VHISKVA 263
           A  V FSI GF A                     E G                 + SK +
Sbjct: 290 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 349

Query: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305
           E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ S   
Sbjct: 350 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 409

Query: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365
                +T L D    S +    +E    L C +   I +    + G Y F +F+ Y+A+ 
Sbjct: 410 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 466

Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425
            +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+F   
Sbjct: 467 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 523

Query: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469
           Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  ++ +
Sbjct: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  284 bits (727), Expect = 1e-76
 Identities = 163/478 (34%), Positives = 240/478 (50%), Gaps = 81/478 (16%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           ++ GS+ VW+ I P  KGLG ASM+  F    YY  +++W  +YL  SF   LPW+ C  
Sbjct: 96  LRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPL 155

Query: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
             N    V+     +CA              R SPV  FW  + L +S  +   G++ W 
Sbjct: 156 NENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGSIQWW 196

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           + LCL   W ++Y C  +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI++   
Sbjct: 197 MLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFT 256

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           P+ ++L  P  W+DAG Q+FFS+++  G L +  SYN  +NNC KD++I+++IN  TS +
Sbjct: 257 PNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVY 316

Query: 240 AGFVVFSILG-------------------------------------------------- 249
              VV+S++G                                                  
Sbjct: 317 VAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYA 376

Query: 250 ---FMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVG 306
              F   +    +S+  E G GLAFI +  A+T MP++PLW+ LFF ML  LGL S F  
Sbjct: 377 QLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGN 435

Query: 307 VEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSAS 364
           +EG +  L DL  +P     ++ +E+   L C   F+I      + G Y   L D Y+ S
Sbjct: 436 MEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491

Query: 365 GTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422
              LL  AF E   V +VYG DRF  DI  MIG++P  + +  W   +PL+ + IF+F
Sbjct: 492 -IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLF 548


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  231 bits (588), Expect = 2e-60
 Identities = 165/539 (30%), Positives = 231/539 (42%), Gaps = 132/539 (24%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+ C  
Sbjct: 69  MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128

Query: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
             N          E+C  AS                  FW  K L +S  L+  G + WE
Sbjct: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
             LCLL  W++VY C+ +G +STGKI                                  
Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKI---------------------------------- 195

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
               +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC K AII++LINS TS F
Sbjct: 196 ---EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 252

Query: 240 AGFVVFSILG---------------------------FMAAEQ---------GVHISKVA 263
           A  V FSI G                           F+ A             + SK +
Sbjct: 253 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 312

Query: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305
           E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ S   
Sbjct: 313 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 372

Query: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365
                +T L D    S +    +E    L C +   I +    + G Y F +F+ Y+A+ 
Sbjct: 373 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 429

Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425
            +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+F   
Sbjct: 430 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 486

Query: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469
           Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  ++ +
Sbjct: 487 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  205 bits (522), Expect = 7e-53
 Identities = 101/253 (39%), Positives = 152/253 (60%), Gaps = 18/253 (7%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           ++ GSI VW+ ICP   G+G++S ++  +   YY +++ W  +Y  KSF   LPW+ C  
Sbjct: 124 IRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC-- 181

Query: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
                    + R     N S+A +  +   ++ S    FW  + L +S  +   G LNW+
Sbjct: 182 --------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGGLNWK 226

Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
           +TLCLL  W +V   V KG++S+GK++YF++ FPYVVL   LVRG+LL GA+DGI++   
Sbjct: 227 MTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFT 286

Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
           P   K+  PQVW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA +++ IN  TS  
Sbjct: 287 PKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346

Query: 240 AGFVVFSILGFMA 252
           A  VVF++LGF A
Sbjct: 347 ATLVVFAVLGFKA 359



 Score =  106 bits (265), Expect = 4e-23
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 266 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 325
           G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S    + G  T ++D       F+
Sbjct: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490

Query: 326 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 385
             +E+    CC   F++ L  V   G Y   +FD YSA+   L      E + VAW+YG 
Sbjct: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549

Query: 386 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419
            +FM ++  M+G+RP  +  + W F +PL CM +
Sbjct: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  200 bits (509), Expect = 2e-51
 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57
           ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW  C  
Sbjct: 125 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184

Query: 58  ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113
                HT+  P+C                       ++ S    +W  + L +S  +   
Sbjct: 185 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 221

Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173
           G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G++DG
Sbjct: 222 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 281

Query: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233
           I +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA++++ IN
Sbjct: 282 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 341

Query: 234 SGTSFFAGFVVFSILGFMA 252
             TS  A  VVF++LGF A
Sbjct: 342 FFTSVLATLVVFAVLGFKA 360



 Score =  125 bits (315), Expect = 7e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489

Query: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547

Query: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607

Query: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459
                 YP WG  +  +  + ++L VP+
Sbjct: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  200 bits (509), Expect = 2e-51
 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57
           ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW  C  
Sbjct: 18  IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 77

Query: 58  ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113
                HT+  P+C                       ++ S    +W  + L +S  +   
Sbjct: 78  VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 114

Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173
           G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G++DG
Sbjct: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174

Query: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233
           I +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA++++ IN
Sbjct: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234

Query: 234 SGTSFFAGFVVFSILGFMA 252
             TS  A  VVF++LGF A
Sbjct: 235 FFTSVLATLVVFAVLGFKA 253



 Score =  125 bits (315), Expect = 7e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382

Query: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440

Query: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500

Query: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459
                 YP WG  +  +  + ++L VP+
Sbjct: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  164 bits (415), Expect = 2e-40
 Identities = 131/501 (26%), Positives = 214/501 (42%), Gaps = 96/501 (19%)

Query: 1   MKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
           M+ G + VW I  P   G+GY+S ++ F    Y+ +V +W  +Y+ +SF   +PW  C  
Sbjct: 167 MRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPL 226

Query: 60  TWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 115
           T N+    P+C                       +R +P I FW  + L+ S  +E  G+
Sbjct: 227 TMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIEDGGS 263

Query: 116 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 175
             + + L    CW LV   +  G+KSTGK++Y     P  ++V   +R +LL GA  G+ 
Sbjct: 264 PVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQ 323

Query: 176 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGA-------------------------LT 210
             +    S + +  VW  AG Q+  +  IGLG+                         L 
Sbjct: 324 QLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLL 383

Query: 211 ALGSYNRFN-------------NNCYKDA-IILALINSG----------------TSFFA 240
            L  +  FN               C ++A I+L LIN G                TS + 
Sbjct: 384 TLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYN 443

Query: 241 GFV------VFSILGFMAAEQGVHISKV-AESGPGLAFIAYPRAVTLMPVAPLWAALFFF 293
            ++      + S++     E  +    + A  GP  AF+++  A++ +P +  W+ +FF 
Sbjct: 444 AWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFL 503

Query: 294 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 353
           MLL +GL S    ++G IT L D      +FR   ++ +     L FV  L      G Y
Sbjct: 504 MLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGVFLLMFVCGLFFTRPSGSY 560

Query: 354 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 413
             +L   Y      ++   F E + V+W YGA RF+ D+  ++G+   P   W W    P
Sbjct: 561 FIRLLSDYWIVFPIIVVVVF-ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCP 619

Query: 414 LVCMGIFIFNVVY--YEPLVY 432
           +V + IF+  +V+   +P+ Y
Sbjct: 620 VVLLIIFVTMMVHLCMKPITY 640


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  100 bits (250), Expect = 2e-21
 Identities = 51/101 (50%), Positives = 61/101 (60%), Gaps = 12/101 (11%)

Query: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62
           G I  W  ICPLF G+GYAS+VIV   N YYI++LAW  YYL +SF   LPWA C H+WN
Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167

Query: 63  TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWE 100
           TP C+E    ++ +     S  N T        SPVIEFWE
Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWE 200


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  100 bits (249), Expect = 3e-21
 Identities = 50/168 (29%), Positives = 86/168 (51%), Gaps = 33/168 (19%)

Query: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57
           ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW  C  
Sbjct: 125 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184

Query: 58  ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113
                HT+  P+C                       ++ S    +W  + L +S  +   
Sbjct: 185 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 221

Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 161
           G LNW++T+CLLA WV+V   + KG++S+GK+   +   P+++L++ +
Sbjct: 222 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLITI 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.329    0.142    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,591,517
Number of Sequences: 37866
Number of extensions: 853523
Number of successful extensions: 2122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2000
Number of HSP's gapped (non-prelim): 42
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.