BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sapiens] (520 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi... 1094 0.0 gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa... 1094 0.0 gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa... 1068 0.0 gi|7657587 solute carrier family 6 (neurotransmitter transporter... 597 e-171 gi|197276623 solute carrier family 6 (neurotransmitter transport... 590 e-168 gi|54607094 solute carrier family 6 (neurotransmitter transporte... 590 e-168 gi|21361581 solute carrier family 6 (neurotransmitter transporte... 590 e-168 gi|171184408 solute carrier family 6 (neurotransmitter transport... 577 e-165 gi|171184406 solute carrier family 6 (neurotransmitter transport... 577 e-165 gi|171184404 solute carrier family 6 (neurotransmitter transport... 577 e-165 gi|188528618 solute carrier family 6 (neurotransmitter transport... 533 e-151 gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap... 423 e-118 gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap... 423 e-118 gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap... 423 e-118 gi|134304856 solute carrier family 6, member 7 [Homo sapiens] 423 e-118 gi|92859670 solute carrier family 6 (neurotransmitter transporte... 417 e-117 gi|4557046 solute carrier family 6 member 2 [Homo sapiens] 414 e-115 gi|4507041 solute carrier family 6 (neurotransmitter transporter... 407 e-113 gi|4507043 solute carrier family 6 member 4 [Homo sapiens] 395 e-110 gi|6005715 solute carrier family 6 (amino acid transporter), mem... 364 e-101 gi|194018524 solute carrier family 6, member 18 [Homo sapiens] 300 2e-81 gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s... 290 2e-78 gi|51468073 solute carrier family 6, member 19 [Homo sapiens] 284 1e-76 gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s... 231 2e-60 gi|58219014 solute carrier family 6, member 17 [Homo sapiens] 205 7e-53 gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s... 200 2e-51 gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ... 200 2e-51 gi|55749589 solute carrier family 6, member 16 [Homo sapiens] 164 2e-40 gi|197276625 solute carrier family 6 (neurotransmitter transport... 100 2e-21 gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s... 100 3e-21 >gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapiens] Length = 635 Score = 1094 bits (2830), Expect = 0.0 Identities = 520/520 (100%), Positives = 520/520 (100%) Query: 1 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT Sbjct: 116 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 175 Query: 61 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV Sbjct: 176 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235 Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295 Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 355 Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL Sbjct: 356 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 415 Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY Sbjct: 416 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 475 Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF Sbjct: 476 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 535 Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT Sbjct: 536 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 595 Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM Sbjct: 596 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 635 >gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sapiens] Length = 520 Score = 1094 bits (2830), Expect = 0.0 Identities = 520/520 (100%), Positives = 520/520 (100%) Query: 1 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT Sbjct: 1 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60 Query: 61 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV Sbjct: 61 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120 Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP Sbjct: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180 Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA Sbjct: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240 Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL Sbjct: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300 Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY Sbjct: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360 Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF Sbjct: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420 Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT Sbjct: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480 Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM Sbjct: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520 >gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sapiens] Length = 625 Score = 1068 bits (2761), Expect = 0.0 Identities = 509/520 (97%), Positives = 510/520 (98%), Gaps = 10/520 (1%) Query: 1 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT Sbjct: 116 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 175 Query: 61 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV Sbjct: 176 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235 Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295 Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY +GTSFFA Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NGTSFFA 345 Query: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL Sbjct: 346 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 405 Query: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY Sbjct: 406 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465 Query: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF Sbjct: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525 Query: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT Sbjct: 526 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 585 Query: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM Sbjct: 586 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 625 >gi|7657587 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 [Homo sapiens] Length = 632 Score = 597 bits (1540), Expect = e-171 Identities = 274/480 (57%), Positives = 356/480 (74%), Gaps = 7/480 (1%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G I W +CPLF+G+GYA+ VI + N YYI++LAW +YL FTT LPWATCGH WN Sbjct: 117 GGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWN 176 Query: 63 TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 122 T +CVE + +++N + L + SPV+EFWE++VL +S G+E G L WE+ L Sbjct: 177 TENCVEFQK------LNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELAL 230 Query: 123 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDW 182 CLLA W + YFC+WKG KSTGK+VY TATFPY++L++LL+RGV LPGA +GI +YL PD Sbjct: 231 CLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDL 290 Query: 183 SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGF 242 S+L PQVW+DAGTQIFFSYAI LG LTALGSYN +NNNCY+D I+L +NSGTSF AGF Sbjct: 291 SRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGF 350 Query: 243 VVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 302 +FS+LGFMA EQGV I++VAESGPGLAFIAYP+AVT+MP++PLWA LFF ML+ LGLDS Sbjct: 351 AIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDS 410 Query: 303 QFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 362 QFV VE +T ++D+ P + ++RE+ + + + + L M+T+GGMY+FQLFD Y+ Sbjct: 411 QFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYA 470 Query: 363 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422 ASG LL+ A +EC+ + WVYG++RF D+I MIGYRP +KWCW TP +C GIFIF Sbjct: 471 ASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIF 530 Query: 423 NVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482 ++ Y+PL YNN Y YP WG +GW ALSSMLC+PL + + + +GT+ E+ Q LT P Sbjct: 531 FLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP 590 >gi|197276623 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 isoform a [Homo sapiens] Length = 620 Score = 590 bits (1521), Expect = e-168 Identities = 282/483 (58%), Positives = 356/483 (73%), Gaps = 12/483 (2%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G I W ICPLF G+GYAS+VIV N YYI++LAW YYL +SF LPWA C H+WN Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167 Query: 63 TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 TP C+E ++ + S N T SPVIEFWE VL LS G++ PG+L W+ Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWERNVLSLSPGIDHPGSLKWD 219 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 + LCLL W++ +FC+WKGV+STGK+VYFTATFP+ +L+VLLVRG+ LPGA GI +YL Sbjct: 220 LALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLY 279 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 PD ++L PQVWIDAGTQIFFSYAI LGA+T+LGSYN++ N Y+D ++L +NSGTSF Sbjct: 280 PDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFV 339 Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299 +GF +FSILGFMA EQGV I+ VAESGPGLAFIAYP+AVT+MP+ W+ LFF MLLLLG Sbjct: 340 SGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLG 399 Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359 LDSQFV VEG IT L+DL P+ ++REI +A C++ +++ L+MVT+GGMYVFQLFD Sbjct: 400 LDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFD 459 Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 YY+ASG LLW AF+EC V+AW+YG D D I MIGYRP PWMK+ W+ TP++C+G Sbjct: 460 YYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGC 519 Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479 FIF++V Y PL YN TYVYP W +GW+ ALSSMLCVPL ++ L + +G R ++L Sbjct: 520 FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYL 579 Query: 480 TQP 482 P Sbjct: 580 LTP 582 >gi|54607094 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 isoform a [Homo sapiens] Length = 620 Score = 590 bits (1521), Expect = e-168 Identities = 282/483 (58%), Positives = 356/483 (73%), Gaps = 12/483 (2%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G I W ICPLF G+GYAS+VIV N YYI++LAW YYL +SF LPWA C H+WN Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167 Query: 63 TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 TP C+E ++ + S N T SPVIEFWE VL LS G++ PG+L W+ Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWERNVLSLSPGIDHPGSLKWD 219 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 + LCLL W++ +FC+WKGV+STGK+VYFTATFP+ +L+VLLVRG+ LPGA GI +YL Sbjct: 220 LALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLY 279 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 PD ++L PQVWIDAGTQIFFSYAI LGA+T+LGSYN++ N Y+D ++L +NSGTSF Sbjct: 280 PDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFV 339 Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299 +GF +FSILGFMA EQGV I+ VAESGPGLAFIAYP+AVT+MP+ W+ LFF MLLLLG Sbjct: 340 SGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLG 399 Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359 LDSQFV VEG IT L+DL P+ ++REI +A C++ +++ L+MVT+GGMYVFQLFD Sbjct: 400 LDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFD 459 Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 YY+ASG LLW AF+EC V+AW+YG D D I MIGYRP PWMK+ W+ TP++C+G Sbjct: 460 YYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGC 519 Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479 FIF++V Y PL YN TYVYP W +GW+ ALSSMLCVPL ++ L + +G R ++L Sbjct: 520 FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYL 579 Query: 480 TQP 482 P Sbjct: 580 LTP 582 >gi|21361581 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] Length = 602 Score = 590 bits (1520), Expect = e-168 Identities = 283/507 (55%), Positives = 356/507 (70%), Gaps = 9/507 (1%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G + W ICP+F+G+GYAS +IV N YYI+VLAW +YL SFT LPW C H WN Sbjct: 99 GGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWN 158 Query: 63 TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 122 T C+E + N + N T SPVIEFWE +VL++S G++ GAL WE+ L Sbjct: 159 TEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGALRWELAL 210 Query: 123 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDW 182 CLL WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA GI +YL P+ Sbjct: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270 Query: 183 SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGF 242 ++L PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY+D I L +NSGTSF AGF Sbjct: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330 Query: 243 VVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 302 +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA FFFM++LLGLDS Sbjct: 331 AIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDS 390 Query: 303 QFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 362 QFV VE +T L+D+ P + + +RE+ + + F++ L M+T+GGMYVFQLFDYY+ Sbjct: 391 QFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYA 450 Query: 363 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422 ASG LL+ A +E + VAWVYGA RF D+I MIGYRP P +K+CW F TP VC F+F Sbjct: 451 ASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLF 510 Query: 423 NVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482 +++ Y PL YN Y YPWWG+A+GW ALSSM+C+P L L KG ER + L P Sbjct: 511 SLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCP 570 Query: 483 IWGLHHLEYRAQDADVRGLTTLTPVSE 509 L A T+L ++E Sbjct: 571 AEDLPQRNPAGPSAPATPRTSLLRLTE 597 >gi|171184408 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Homo sapiens] Length = 614 Score = 577 bits (1487), Expect = e-165 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 GS+ W ICPLF+G+G AS+VI Y N YYI++LAW +YL SFT+ LPW TC + WN Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162 Query: 63 TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121 T C + H + N T SPV+EFWE +VL ++ G+ G+L WE+ Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214 Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181 LCLL WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA GIIYYLKPD Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274 Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241 +L PQVW+DAGTQIFFS+AI G LTALGSYN+++NNCYKD I L +NS TSF AG Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334 Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301 FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394 Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361 SQFV VE +T +D+ P +RE+ + +C++I L +VT+GGMY+FQLFDYY Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454 Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421 ++SG LL+ + +E V ++WVYGADRF D+I MIGYRP P +K W F TP +C+ F+ Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514 Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481 F++ Y PL YNN YVYP WG ++GW ALSSM+CVPL ++ LL+ +G +R + L Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574 Query: 482 P 482 P Sbjct: 575 P 575 >gi|171184406 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Homo sapiens] Length = 614 Score = 577 bits (1487), Expect = e-165 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 GS+ W ICPLF+G+G AS+VI Y N YYI++LAW +YL SFT+ LPW TC + WN Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162 Query: 63 TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121 T C + H + N T SPV+EFWE +VL ++ G+ G+L WE+ Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214 Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181 LCLL WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA GIIYYLKPD Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274 Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241 +L PQVW+DAGTQIFFS+AI G LTALGSYN+++NNCYKD I L +NS TSF AG Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334 Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301 FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394 Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361 SQFV VE +T +D+ P +RE+ + +C++I L +VT+GGMY+FQLFDYY Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454 Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421 ++SG LL+ + +E V ++WVYGADRF D+I MIGYRP P +K W F TP +C+ F+ Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514 Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481 F++ Y PL YNN YVYP WG ++GW ALSSM+CVPL ++ LL+ +G +R + L Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574 Query: 482 P 482 P Sbjct: 575 P 575 >gi|171184404 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Homo sapiens] Length = 614 Score = 577 bits (1487), Expect = e-165 Identities = 272/481 (56%), Positives = 348/481 (72%), Gaps = 10/481 (2%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 GS+ W ICPLF+G+G AS+VI Y N YYI++LAW +YL SFT+ LPW TC + WN Sbjct: 103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWN 162 Query: 63 TPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVT 121 T C + H + N T SPV+EFWE +VL ++ G+ G+L WE+ Sbjct: 163 TEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIHDLGSLRWELA 214 Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181 LCLL WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA GIIYYLKPD Sbjct: 215 LCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274 Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241 +L PQVW+DAGTQIFFS+AI G LTALGSYN+++NNCYKD I L +NS TSF AG Sbjct: 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334 Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301 FVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LFF ML+ LGLD Sbjct: 335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLD 394 Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361 SQFV VE +T +D+ P +RE+ + +C++I L +VT+GGMY+FQLFDYY Sbjct: 395 SQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYY 454 Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421 ++SG LL+ + +E V ++WVYGADRF D+I MIGYRP P +K W F TP +C+ F+ Sbjct: 455 ASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514 Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481 F++ Y PL YNN YVYP WG ++GW ALSSM+CVPL ++ LL+ +G +R + L Sbjct: 515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLIT 574 Query: 482 P 482 P Sbjct: 575 P 575 >gi|188528618 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [Homo sapiens] Length = 599 Score = 533 bits (1373), Expect = e-151 Identities = 248/479 (51%), Positives = 337/479 (70%), Gaps = 16/479 (3%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G + VW + P+FKG+G A+ V+ F+ N YYI++++W YYL SFTTTLPW C + WNT Sbjct: 111 GGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNT 170 Query: 64 PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLC 123 C +N S+ N T + S V+EFWE + +++ GL+ PG + W + + Sbjct: 171 DRCF--------SNYSMVNTT-----NMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAIT 217 Query: 124 LLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWS 183 L W+LVYFC+WKGV TGK+VYF+AT+PY++L++L RGV LPGA +GI++Y+ P++ Sbjct: 218 LAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFR 277 Query: 184 KLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFV 243 KL +VW+DA TQIFFSY +GLG+L ALGSYN F+NN Y+D+II+ INS TS FAGFV Sbjct: 278 KLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337 Query: 244 VFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQ 303 +FSI+GFMA I+ VA SGPGLAF+AYP AVT +P++PLWA LFF MLL+LG+DSQ Sbjct: 338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQ 397 Query: 304 FVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSA 363 F VEGFIT L+D P R +RE+ +A C + ++I LS +T GG+YVF+LFDYYSA Sbjct: 398 FCTVEGFITALVDEYPR--LLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA 455 Query: 364 SGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFN 423 SG +LL+ F+ECV ++W YG +RF D+I M+G RPC W K CWSFFTP++ G+FIF+ Sbjct: 456 SGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFS 515 Query: 424 VVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482 V PL N YV+P WG+ +GW ALSSM+ +P ++ L KG++ +R Q + QP Sbjct: 516 AVQMTPLTMGN-YVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQP 573 >gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sapiens] Length = 633 Score = 423 bits (1087), Expect = e-118 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G + VW I P+FKG+GY MV+ Y YY +V+ FYY S T LPWA C + WNT Sbjct: 94 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 153 Query: 64 PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116 DC + + N S +NL+ + R SP E+W VL+LS + G + Sbjct: 154 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 213 Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176 + CL W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y Sbjct: 214 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 273 Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236 YL P W K+ +VW DA +QIF+S G L + SYN+F+NNCY+D++I+++ N T Sbjct: 274 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 333 Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296 S +AGFV+FSILGFMA GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+ Sbjct: 334 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 393 Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356 LLGL +QF +E +T ++D + + + + +++ + A F++ + + + G+Y Sbjct: 394 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 452 Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416 L D Y+AS + ++ CV + ++YG + DI M+G+ P + + CW F +P + Sbjct: 453 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 511 Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475 I +F V+ Y+P+ YN+ Y YP W A+G+ ALSS+LC+PL+ + L R G T+ +R Sbjct: 512 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 570 Query: 476 WQHLTQPI--WGLHHLEYR 492 ++ T+P WG LE+R Sbjct: 571 LKNATKPSRDWGPALLEHR 589 >gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sapiens] Length = 706 Score = 423 bits (1087), Expect = e-118 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G + VW I P+FKG+GY MV+ Y YY +V+ FYY S T LPWA C + WNT Sbjct: 167 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 226 Query: 64 PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116 DC + + N S +NL+ + R SP E+W VL+LS + G + Sbjct: 227 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 286 Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176 + CL W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y Sbjct: 287 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 346 Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236 YL P W K+ +VW DA +QIF+S G L + SYN+F+NNCY+D++I+++ N T Sbjct: 347 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 406 Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296 S +AGFV+FSILGFMA GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+ Sbjct: 407 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 466 Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356 LLGL +QF +E +T ++D + + + + +++ + A F++ + + + G+Y Sbjct: 467 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 525 Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416 L D Y+AS + ++ CV + ++YG + DI M+G+ P + + CW F +P + Sbjct: 526 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 584 Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475 I +F V+ Y+P+ YN+ Y YP W A+G+ ALSS+LC+PL+ + L R G T+ +R Sbjct: 585 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 643 Query: 476 WQHLTQPI--WGLHHLEYR 492 ++ T+P WG LE+R Sbjct: 644 LKNATKPSRDWGPALLEHR 662 >gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sapiens] Length = 652 Score = 423 bits (1087), Expect = e-118 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G + VW I P+FKG+GY MV+ Y YY +V+ FYY S T LPWA C + WNT Sbjct: 113 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 172 Query: 64 PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116 DC + + N S +NL+ + R SP E+W VL+LS + G + Sbjct: 173 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 232 Query: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176 + CL W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y Sbjct: 233 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 292 Query: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236 YL P W K+ +VW DA +QIF+S G L + SYN+F+NNCY+D++I+++ N T Sbjct: 293 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 352 Query: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296 S +AGFV+FSILGFMA GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+ Sbjct: 353 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412 Query: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356 LLGL +QF +E +T ++D + + + + +++ + A F++ + + + G+Y Sbjct: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 471 Query: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416 L D Y+AS + ++ CV + ++YG + DI M+G+ P + + CW F +P + Sbjct: 472 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 530 Query: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475 I +F V+ Y+P+ YN+ Y YP W A+G+ ALSS+LC+PL+ + L R G T+ +R Sbjct: 531 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 589 Query: 476 WQHLTQPI--WGLHHLEYR 492 ++ T+P WG LE+R Sbjct: 590 LKNATKPSRDWGPALLEHR 608 >gi|134304856 solute carrier family 6, member 7 [Homo sapiens] Length = 636 Score = 423 bits (1087), Expect = e-118 Identities = 215/486 (44%), Positives = 302/486 (62%), Gaps = 13/486 (2%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G + VW I PLFKG G A ++IV YY M++A+ +YL S T+ LPW CG+ WNT Sbjct: 104 GPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNT 163 Query: 64 PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPGALNWEVT 121 C+E +D A NLTC SP E+W VL + G G+ PG + W + Sbjct: 164 ELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLC 218 Query: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181 LCLL WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA GI +YL P Sbjct: 219 LCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQ 278 Query: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241 + L S +VWI+A QIF+S +G G L SYN F+ N Y+D I+ L N+ TS AG Sbjct: 279 FHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAG 338 Query: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301 F +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFMLL LGLD Sbjct: 339 FAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLD 398 Query: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361 SQF +E +T + D P YY R ++ + L C +++ L + TDGGMY L D Y Sbjct: 399 SQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDY 456 Query: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421 SAS L+ C+ V VYG RF DI M+G++P + + CW F +P + + + Sbjct: 457 SAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515 Query: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481 +++V Y+P Y +Y +P W E +G L S L +P +L +LR +G++ ER Q ++ Sbjct: 516 YSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASR 574 Query: 482 PI--WG 485 P WG Sbjct: 575 PAMDWG 580 >gi|92859670 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 [Homo sapiens] Length = 797 Score = 417 bits (1073), Expect = e-117 Identities = 214/532 (40%), Positives = 308/532 (57%), Gaps = 32/532 (6%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G ++VW P +G G A ++I YY +++ + +YL SF + LPW +C + WNT Sbjct: 258 GPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNT 317 Query: 64 PDC------------------VEIFRHEDCA----NASLANLTCDQLADRRSPVIEFWEN 101 P+C ++I C N ++ N T S E+++ Sbjct: 318 PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKY 377 Query: 102 KVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 161 VL++S G+E PG + W + LCL WV+VY + KG+K++GK+VYFTATFPYVVLV+LL Sbjct: 378 FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILL 437 Query: 162 VRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNN 221 +RGV LPGA GI Y++ P W KL VW DA TQIFFS + G L L SYN+F+NN Sbjct: 438 IRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNN 497 Query: 222 CYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLM 281 CY+D +I+ NS TS FAGFV+FS++GFMA E+ V+I VA+ GPG+AF+ YP A+T + Sbjct: 498 CYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRL 557 Query: 282 PVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFV 341 P++P WA +FF MLL LGLD+ F +E +T + D P Y R + + CC F+ Sbjct: 558 PLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLGCCICFFI 615 Query: 342 IDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPC 401 + M+T GG+Y+FQL D Y+AS L+ A +E V +++VYG RF +DI MIG++P Sbjct: 616 MGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPN 674 Query: 402 PWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHL 461 + K CW+F TP + I F+ +EP+ Y +Y YP W +GW S++ +P+ Sbjct: 675 IFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSVIWIPIMF 733 Query: 462 LGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 511 + + A G ER + + QP WG + AQ R + P+ SS Sbjct: 734 VIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781 >gi|4557046 solute carrier family 6 member 2 [Homo sapiens] Length = 617 Score = 414 bits (1063), Expect = e-115 Identities = 210/490 (42%), Positives = 298/490 (60%), Gaps = 12/490 (2%) Query: 2 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTW 61 + G+ VW ICP FKG+GYA ++I Y YY +++AW YYL SFT LPW CGHTW Sbjct: 121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW 180 Query: 62 NTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWE 119 N+P+C + N S+ + +P EF+E VL L S G+ G W+ Sbjct: 181 NSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQ 236 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 + LCL+ +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +GI YL Sbjct: 237 LLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLH 296 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 D+ +L VWIDA TQIFFS G G L A SYN+F+NNCY+DA++ + IN TSF Sbjct: 297 IDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFV 356 Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299 +GF +FSILG+MA E V+I VA G GL FI YP A++ + + WA +FF MLL LG Sbjct: 357 SGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALG 416 Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359 LDS G+E ITGL D + R++ F++ L +T GG+YV L D Sbjct: 417 LDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLD 473 Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 + A+GT++L+ E + V+W YG DRF +DI M+G+RP + + CW F +P + + Sbjct: 474 TF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532 Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479 + +++ ++PL Y++ Y++P W +GW ALSSM+ VP++++ L +G++ ER + Sbjct: 533 VVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYG 591 Query: 480 TQPIWGLHHL 489 P HHL Sbjct: 592 ITP-ENEHHL 600 >gi|4507041 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [Homo sapiens] Length = 620 Score = 407 bits (1045), Expect = e-113 Identities = 204/483 (42%), Positives = 290/483 (60%), Gaps = 12/483 (2%) Query: 2 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTW 61 + G+ VW ICP+ KG+G+ ++I Y +Y +++AW +YL SFTT LPW C ++W Sbjct: 125 REGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSW 184 Query: 62 NTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWE 119 N+P+C + + ++S N T +P E++E VL L S G++ G W+ Sbjct: 185 NSPNCSDAHPGDSSGDSSGLNDTFGT-----TPAAEYFERGVLHLHQSHGIDDLGPPRWQ 239 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 +T CL+ VL+YF +WKGVK++GK+V+ TAT PYVVL LL+RGV LPGA+DGI YL Sbjct: 240 LTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 D+ +L VWIDA TQ+ FS +G G L A SYN+F NNCY+DAI+ INS TSF Sbjct: 300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFS 359 Query: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299 +GFVVFS LG+MA + V I VA+ GPGL FI YP A+ +P++ WA +FF MLL LG Sbjct: 360 SGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLG 419 Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359 +DS G+E ITGL+D + RE+ F++ L VT+GG+YVF L D Sbjct: 420 IDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLATFLLSLFCVTNGGIYVFTLLD 476 Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 ++ A+GT++L+ E + VAW YG +F DDI M G RP + + CW +P + + Sbjct: 477 HF-AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFV 535 Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479 + ++V + P Y Y++P W A+GW A SSM VP++ G+ E+ + Sbjct: 536 VVVSIVTFRPPHY-GAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYA 594 Query: 480 TQP 482 P Sbjct: 595 IAP 597 >gi|4507043 solute carrier family 6 member 4 [Homo sapiens] Length = 630 Score = 395 bits (1015), Expect = e-110 Identities = 201/476 (42%), Positives = 292/476 (61%), Gaps = 18/476 (3%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G I++W ICP+FKG+GYA +I FY +YY ++AW YYL+ SFT LPW +C ++WN Sbjct: 146 GCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWN 205 Query: 63 TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWEV 120 T +C F + N+T SP EF+ VL++ S GL+ G ++W++ Sbjct: 206 TGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255 Query: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180 LC++ + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG LPGA G+++YLKP Sbjct: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315 Query: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240 +W KL VWIDA QIFFS G G L A SYN+FNNNCY+DA++ +++N TSF + Sbjct: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVS 375 Query: 241 GFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299 GFV+F++LG+MA + +S+VA ++GP L FI Y A+ MP + +A +FF ML+ LG Sbjct: 376 GFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLG 435 Query: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359 LDS F G+EG IT +LD P + + +RE V CF L +T GG YV +L + Sbjct: 436 LDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493 Query: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 Y A+G +L A E V V+W YG +F D+ M+G+ P + + CW +PL + I Sbjct: 494 EY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552 Query: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 475 I + + P + Y YP+W +G+ SS +C+P ++ L+ GT ER Sbjct: 553 -ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607 >gi|6005715 solute carrier family 6 (amino acid transporter), member 14 [Homo sapiens] Length = 642 Score = 364 bits (935), Expect = e-101 Identities = 199/522 (38%), Positives = 301/522 (57%), Gaps = 39/522 (7%) Query: 4 GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63 G ++VW I PLF+G+G ++I + YY +++A+ YY+ SF + LPW C +W+ Sbjct: 103 GPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCS-SWSD 161 Query: 64 PDCVE--IFRHEDCANAS---------------LANLTCDQLAD----RRSPVIEFWENK 102 +C I H + + + + N TC ++ + P ++W Sbjct: 162 KNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKV 221 Query: 103 VLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLV 162 L+ S G+ G + W + LCLL W++V ++KG+KS+GK+VYFTA FPYVVL++LLV Sbjct: 222 ALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLV 281 Query: 163 RGVLLPGALDGIIYYL--KPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNN 220 RG L GA GI YY+ + +++KL +VW DA TQIF+S ++ G L AL SYN+F N Sbjct: 282 RGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKN 341 Query: 221 NCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTL 280 NC+ DAI++ L N TS FAGF +FSILG MA G +S+V +SG LAFIAYP A+ Sbjct: 342 NCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQ 401 Query: 281 MPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVAL---CCA 337 +P P W+ LFFFMLL LGLDSQF +E T + DL P + +++ V + CC Sbjct: 402 LPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFP-----KVMKKMRVPITLGCCL 456 Query: 338 LCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIG 397 + F++ L VT G+Y L D++ A G +L A E V + W+YG +RF++D MIG Sbjct: 457 VLFLLGLVCVTQAGIYWVHLIDHFCA-GWGILIAAILELVGIIWIYGGNRFIEDTEMMIG 515 Query: 398 -YRPCPWMKW--CWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSM 454 R W+ W CW TP++ + IFI+++V + Y YP WG A+GW + + Sbjct: 516 AKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNY-GAIPYPDWGVALGWCMIVFCI 574 Query: 455 LCVPLHLLGCLLRAKGTMAERWQHLTQPI--WGLHHLEYRAQ 494 + +P+ + +++AKG + +R +P WG + ++R + Sbjct: 575 IWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGE 616 >gi|194018524 solute carrier family 6, member 18 [Homo sapiens] Length = 628 Score = 300 bits (768), Expect = 2e-81 Identities = 188/545 (34%), Positives = 269/545 (49%), Gaps = 95/545 (17%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 ++ GS+ VW I P G+G + + F + YY ++AW +YL+ SF LPW++C Sbjct: 82 LRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPP 141 Query: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 N VE +C +S + FW + L ++ + G++ W Sbjct: 142 DLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGSIQWW 182 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA G+IY Sbjct: 183 LLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFT 242 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 P+ L +P+VW+DA TQIFFS ++ G A SYN N+C KDA+++AL+N TS + Sbjct: 243 PNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLY 302 Query: 240 AGFVVFSILGFMAAEQGVHI------------------------------------SKVA 263 A VFS+LGF A H +VA Sbjct: 303 ASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVA 362 Query: 264 E----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGV 307 + SGPGLAF+ + MP AP+WA LFF ML LGL + F V Sbjct: 363 QLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTV 422 Query: 308 EGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365 E IT LLD +LP +E L C +CF+ G Y ++FD ++AS Sbjct: 423 EAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAAS- 477 Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425 LL AF E V V +VYG RF DDIA M G RP P+ + W +PL+ + IF+ ++ Sbjct: 478 PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFVAYII 536 Query: 426 --YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL-RAKG 470 +++PL Y N Y +YP W A +L +L VP+ L LL R + Sbjct: 537 LLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRR 596 Query: 471 TMAER 475 T +R Sbjct: 597 TWRDR 601 >gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo sapiens] Length = 592 Score = 290 bits (743), Expect = 2e-78 Identities = 184/539 (34%), Positives = 258/539 (47%), Gaps = 95/539 (17%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 M+ GSI W I P G+G AS+V+ F+ + YY ++ AW F+YL SF LPW+ C Sbjct: 69 MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128 Query: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 N E+C AS FW K L +S L+ G + WE Sbjct: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 LCLL W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++Y Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFT 229 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 P +L +P+ WI+A TQIFFS +G G+L A SYN +NNC K AII++LINS TS F Sbjct: 230 PKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 289 Query: 240 AGFVVFSILGFMAA--------------------EQG----------------VHISKVA 263 A V FSI GF A E G + SK + Sbjct: 290 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 349 Query: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305 E G GLAFI Y A+ M V+ LW+ L+FFMLL+LG+ S Sbjct: 350 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 409 Query: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365 +T L D S + +E L C + I + + G Y F +F+ Y+A+ Sbjct: 410 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 466 Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425 +LL E + V +VYG RF D+ M G + K W+ +PL+ + +F+F Sbjct: 467 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 523 Query: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469 Y + T Y W + G A+AL SS +C+PL LG ++ + Sbjct: 524 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 582 >gi|51468073 solute carrier family 6, member 19 [Homo sapiens] Length = 634 Score = 284 bits (727), Expect = 1e-76 Identities = 163/478 (34%), Positives = 240/478 (50%), Gaps = 81/478 (16%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 ++ GS+ VW+ I P KGLG ASM+ F YY +++W +YL SF LPW+ C Sbjct: 96 LRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPL 155 Query: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 N V+ +CA R SPV FW + L +S + G++ W Sbjct: 156 NENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGSIQWW 196 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 + LCL W ++Y C +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI++ Sbjct: 197 MLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFT 256 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 P+ ++L P W+DAG Q+FFS+++ G L + SYN +NNC KD++I+++IN TS + Sbjct: 257 PNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVY 316 Query: 240 AGFVVFSILG-------------------------------------------------- 249 VV+S++G Sbjct: 317 VAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYA 376 Query: 250 ---FMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVG 306 F + +S+ E G GLAFI + A+T MP++PLW+ LFF ML LGL S F Sbjct: 377 QLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGN 435 Query: 307 VEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSAS 364 +EG + L DL +P ++ +E+ L C F+I + G Y L D Y+ S Sbjct: 436 MEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491 Query: 365 GTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422 LL AF E V +VYG DRF DI MIG++P + + W +PL+ + IF+F Sbjct: 492 -IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLF 548 >gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo sapiens] Length = 555 Score = 231 bits (588), Expect = 2e-60 Identities = 165/539 (30%), Positives = 231/539 (42%), Gaps = 132/539 (24%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 M+ GSI W I P G+G AS+V+ F+ + YY ++ AW F+YL SF LPW+ C Sbjct: 69 MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128 Query: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 N E+C AS FW K L +S L+ G + WE Sbjct: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 LCLL W++VY C+ +G +STGKI Sbjct: 170 PALCLLLAWLVVYLCILRGTESTGKI---------------------------------- 195 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 +L +P+ WI+A TQIFFS +G G+L A SYN +NNC K AII++LINS TS F Sbjct: 196 ---EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 252 Query: 240 AGFVVFSILG---------------------------FMAAEQ---------GVHISKVA 263 A V FSI G F+ A + SK + Sbjct: 253 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 312 Query: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305 E G GLAFI Y A+ M V+ LW+ L+FFMLL+LG+ S Sbjct: 313 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 372 Query: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365 +T L D S + +E L C + I + + G Y F +F+ Y+A+ Sbjct: 373 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 429 Query: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425 +LL E + V +VYG RF D+ M G + K W+ +PL+ + +F+F Sbjct: 430 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 486 Query: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469 Y + T Y W + G A+AL SS +C+PL LG ++ + Sbjct: 487 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545 >gi|58219014 solute carrier family 6, member 17 [Homo sapiens] Length = 727 Score = 205 bits (522), Expect = 7e-53 Identities = 101/253 (39%), Positives = 152/253 (60%), Gaps = 18/253 (7%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 ++ GSI VW+ ICP G+G++S ++ + YY +++ W +Y KSF LPW+ C Sbjct: 124 IRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC-- 181 Query: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119 + R N S+A + + ++ S FW + L +S + G LNW+ Sbjct: 182 --------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGGLNWK 226 Query: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179 +TLCLL W +V V KG++S+GK++YF++ FPYVVL LVRG+LL GA+DGI++ Sbjct: 227 MTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFT 286 Query: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239 P K+ PQVW +A TQ+FF+ +G G + A SYN+ +NNC+ DA +++ IN TS Sbjct: 287 PKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346 Query: 240 AGFVVFSILGFMA 252 A VVF++LGF A Sbjct: 347 ATLVVFAVLGFKA 359 Score = 106 bits (265), Expect = 4e-23 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Query: 266 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 325 G GLAFIA+ A+T P +P W+ +FF ML+ LGL S + G T ++D F+ Sbjct: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490 Query: 326 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 385 +E+ CC F++ L V G Y +FD YSA+ L E + VAW+YG Sbjct: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549 Query: 386 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419 +FM ++ M+G+RP + + W F +PL CM + Sbjct: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582 >gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo sapiens] Length = 730 Score = 200 bits (509), Expect = 2e-51 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57 ++ GSI VWN I P G+G+AS V+ ++ YY +++ W +Y +SF LPW C Sbjct: 125 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184 Query: 58 ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113 HT+ P+C ++ S +W + L +S + Sbjct: 185 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 221 Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173 G LNW++T+CLLA WV+V + KG++S+GKI+YF++ FPYVVL+ L+R LL G++DG Sbjct: 222 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 281 Query: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233 I + P + P+VW +A TQ+FF+ +G G + A SYN+ +NNC+ DA++++ IN Sbjct: 282 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 341 Query: 234 SGTSFFAGFVVFSILGFMA 252 TS A VVF++LGF A Sbjct: 342 FFTSVLATLVVFAVLGFKA 360 Score = 125 bits (315), Expect = 7e-29 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%) Query: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322 A G GLAFIA+ A+T P +P W+ +FF ML+ LGL S F +EG +T ++D Sbjct: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489 Query: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382 F+ ++EI +CC L F I L V G Y +FD YSA+ LL E + V +V Sbjct: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547 Query: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431 YG D+FM+D+ M+G+ P + + W + +PL+ + + I +VV + E Sbjct: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607 Query: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459 YP WG + + + ++L VP+ Sbjct: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635 >gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo sapiens] Length = 623 Score = 200 bits (509), Expect = 2e-51 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57 ++ GSI VWN I P G+G+AS V+ ++ YY +++ W +Y +SF LPW C Sbjct: 18 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 77 Query: 58 ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113 HT+ P+C ++ S +W + L +S + Sbjct: 78 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 114 Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173 G LNW++T+CLLA WV+V + KG++S+GKI+YF++ FPYVVL+ L+R LL G++DG Sbjct: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174 Query: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233 I + P + P+VW +A TQ+FF+ +G G + A SYN+ +NNC+ DA++++ IN Sbjct: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234 Query: 234 SGTSFFAGFVVFSILGFMA 252 TS A VVF++LGF A Sbjct: 235 FFTSVLATLVVFAVLGFKA 253 Score = 125 bits (315), Expect = 7e-29 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%) Query: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322 A G GLAFIA+ A+T P +P W+ +FF ML+ LGL S F +EG +T ++D Sbjct: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382 Query: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382 F+ ++EI +CC L F I L V G Y +FD YSA+ LL E + V +V Sbjct: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440 Query: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431 YG D+FM+D+ M+G+ P + + W + +PL+ + + I +VV + E Sbjct: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500 Query: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459 YP WG + + + ++L VP+ Sbjct: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528 >gi|55749589 solute carrier family 6, member 16 [Homo sapiens] Length = 736 Score = 164 bits (415), Expect = 2e-40 Identities = 131/501 (26%), Positives = 214/501 (42%), Gaps = 96/501 (19%) Query: 1 MKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59 M+ G + VW I P G+GY+S ++ F Y+ +V +W +Y+ +SF +PW C Sbjct: 167 MRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPL 226 Query: 60 TWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 115 T N+ P+C +R +P I FW + L+ S +E G+ Sbjct: 227 TMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIEDGGS 263 Query: 116 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 175 + + L CW LV + G+KSTGK++Y P ++V +R +LL GA G+ Sbjct: 264 PVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQ 323 Query: 176 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGA-------------------------LT 210 + S + + VW AG Q+ + IGLG+ L Sbjct: 324 QLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLL 383 Query: 211 ALGSYNRFN-------------NNCYKDA-IILALINSG----------------TSFFA 240 L + FN C ++A I+L LIN G TS + Sbjct: 384 TLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYN 443 Query: 241 GFV------VFSILGFMAAEQGVHISKV-AESGPGLAFIAYPRAVTLMPVAPLWAALFFF 293 ++ + S++ E + + A GP AF+++ A++ +P + W+ +FF Sbjct: 444 AWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFL 503 Query: 294 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 353 MLL +GL S ++G IT L D +FR ++ + L FV L G Y Sbjct: 504 MLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGVFLLMFVCGLFFTRPSGSY 560 Query: 354 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 413 +L Y ++ F E + V+W YGA RF+ D+ ++G+ P W W P Sbjct: 561 FIRLLSDYWIVFPIIVVVVF-ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCP 619 Query: 414 LVCMGIFIFNVVY--YEPLVY 432 +V + IF+ +V+ +P+ Y Sbjct: 620 VVLLIIFVTMMVHLCMKPITY 640 >gi|197276625 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 isoform b [Homo sapiens] Length = 200 Score = 100 bits (250), Expect = 2e-21 Identities = 51/101 (50%), Positives = 61/101 (60%), Gaps = 12/101 (11%) Query: 4 GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62 G I W ICPLF G+GYAS+VIV N YYI++LAW YYL +SF LPWA C H+WN Sbjct: 108 GGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWN 167 Query: 63 TPDCVEIFRHEDCA---NASLANLTCDQLADRRSPVIEFWE 100 TP C+E ++ + S N T SPVIEFWE Sbjct: 168 TPHCMEDTMRKNKSVWITISSTNFT--------SPVIEFWE 200 >gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo sapiens] Length = 289 Score = 100 bits (249), Expect = 3e-21 Identities = 50/168 (29%), Positives = 86/168 (51%), Gaps = 33/168 (19%) Query: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57 ++ GSI VWN I P G+G+AS V+ ++ YY +++ W +Y +SF LPW C Sbjct: 125 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184 Query: 58 ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113 HT+ P+C ++ S +W + L +S + Sbjct: 185 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 221 Query: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 161 G LNW++T+CLLA WV+V + KG++S+GK+ + P+++L++ + Sbjct: 222 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLITI 266 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.329 0.142 0.488 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,591,517 Number of Sequences: 37866 Number of extensions: 853523 Number of successful extensions: 2122 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 30 Number of HSP's successfully gapped in prelim test: 2 Number of HSP's that attempted gapping in prelim test: 2000 Number of HSP's gapped (non-prelim): 42 length of query: 520 length of database: 18,247,518 effective HSP length: 107 effective length of query: 413 effective length of database: 14,195,856 effective search space: 5862888528 effective search space used: 5862888528 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.