Search of human proteins with 218563756

Search of human proteins with 218563756

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
sapiens]
         (625 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...  1316   0.0  
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...  1306   0.0  
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...  1068   0.0  
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   672   0.0  
gi|197276623 solute carrier family 6 (neurotransmitter transport...   668   0.0  
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   668   0.0  
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   657   0.0  
gi|171184408 solute carrier family 6 (neurotransmitter transport...   651   0.0  
gi|171184406 solute carrier family 6 (neurotransmitter transport...   651   0.0  
gi|171184404 solute carrier family 6 (neurotransmitter transport...   651   0.0  
gi|188528618 solute carrier family 6 (neurotransmitter transport...   616   e-176
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         504   e-143
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   502   e-142
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            499   e-141
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   498   e-141
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   498   e-141
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   497   e-140
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   487   e-137
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            483   e-136
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   440   e-123
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        361   1e-99
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   350   2e-96
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         345   7e-95
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   294   2e-79
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         277   2e-74
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   273   5e-73
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   205   9e-53
gi|197276625 solute carrier family 6 (neurotransmitter transport...   196   4e-50
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   189   5e-48
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         164   2e-40

>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score = 1316 bits (3406), Expect = 0.0
 Identities = 625/625 (100%), Positives = 625/625 (100%)

Query: 1   MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD 60
           MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD
Sbjct: 1   MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD 60

Query: 61  FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS 120
           FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS
Sbjct: 61  FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS 120

Query: 121 INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180
           INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
Sbjct: 121 INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180

Query: 181 CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL 240
           CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL
Sbjct: 181 CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL 240

Query: 241 ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL 300
           ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
Sbjct: 241 ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL 300

Query: 301 GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAGFVVFSILGFMAAEQ 360
           GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAGFVVFSILGFMAAEQ
Sbjct: 301 GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAGFVVFSILGFMAAEQ 360

Query: 361 GVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLL 420
           GVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLL
Sbjct: 361 GVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLL 420

Query: 421 DLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWE 480
           DLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWE
Sbjct: 421 DLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWE 480

Query: 481 CVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNT 540
           CVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNT
Sbjct: 481 CVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNT 540

Query: 541 YVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQD 600
           YVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQD
Sbjct: 541 YVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQD 600

Query: 601 ADVRGLTTLTPVSESSKVVVVESVM 625
           ADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 601 ADVRGLTTLTPVSESSKVVVVESVM 625


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score = 1306 bits (3380), Expect = 0.0
 Identities = 624/635 (98%), Positives = 625/635 (98%), Gaps = 10/635 (1%)

Query: 1   MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD 60
           MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD
Sbjct: 1   MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD 60

Query: 61  FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS 120
           FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS
Sbjct: 61  FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS 120

Query: 121 INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180
           INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
Sbjct: 121 INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD 180

Query: 181 CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL 240
           CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL
Sbjct: 181 CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL 240

Query: 241 ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL 300
           ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
Sbjct: 241 ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL 300

Query: 301 GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NGTSFFAGFVVF 350
           GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY          +GTSFFAGFVVF
Sbjct: 301 GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVF 360

Query: 351 SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 410
           SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV
Sbjct: 361 SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 420

Query: 411 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 470
           GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG
Sbjct: 421 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 480

Query: 471 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 530
           TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV
Sbjct: 481 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 540

Query: 531 YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG 590
           YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG
Sbjct: 541 YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG 600

Query: 591 LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 625
           LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 601 LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 635


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score = 1068 bits (2761), Expect = 0.0
 Identities = 509/520 (97%), Positives = 510/520 (98%), Gaps = 10/520 (1%)

Query: 116 MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 175
           MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT
Sbjct: 1   MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHT 60

Query: 176 WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235
           WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV
Sbjct: 61  WNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 120

Query: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295
           TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP
Sbjct: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180

Query: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NGTSFFA 345
           DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY          +GTSFFA
Sbjct: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240

Query: 346 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 405
           GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL
Sbjct: 241 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 300

Query: 406 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465
           DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY
Sbjct: 301 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 360

Query: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525
           YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF
Sbjct: 361 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 420

Query: 526 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 585
           IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT
Sbjct: 421 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLT 480

Query: 586 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 625
           QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Sbjct: 481 QPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM 520


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  672 bits (1733), Expect = 0.0
 Identities = 317/575 (55%), Positives = 408/575 (70%), Gaps = 18/575 (3%)

Query: 24  APGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCY 83
           APG  G  + G  P          AV  R  W  +++F++S  G  +GLGNVWRFPYLCY
Sbjct: 23  APG-GGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCY 81

Query: 84  KNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVF 142
           KNGGG FLIPYV+  +  GIP+FFLE +LGQF   G I  W  +CPLF+G+GYA+ VI  
Sbjct: 82  KNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEA 141

Query: 143 YCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQ 202
           + N YYI++LAW  +YL   FTT LPWATCGH WNT +CVE  +       +++N +   
Sbjct: 142 HLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQK------LNVSNYSHVS 195

Query: 203 LADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVY 262
           L +  SPV+EFWE++VL +S G+E  G L WE+ LCLLA W + YFC+WKG KSTGK+VY
Sbjct: 196 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY 255

Query: 263 FTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLG 322
            TATFPY++L++LL+RGV LPGA +GI +YL PD S+L  PQVW+DAGTQIFFSYAI LG
Sbjct: 256 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG 315

Query: 323 ALTALGSYNRFNNNCY----------NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGP 372
            LTALGSYN +NNNCY          +GTSF AGF +FS+LGFMA EQGV I++VAESGP
Sbjct: 316 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP 375

Query: 373 GLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQ 432
           GLAFIAYP+AVT+MP++PLWA LFF ML+ LGLDSQFV VE  +T ++D+ P  +   ++
Sbjct: 376 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR 435

Query: 433 REISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADR 492
           RE+ +     + + + L M+T+GGMY+FQLFD Y+ASG  LL+ A +EC+ + WVYG++R
Sbjct: 436 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR 495

Query: 493 FMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGW 552
           F D+I  MIGYRP   +KWCW   TP +C GIFIF ++ Y+PL YNN Y YP WG  +GW
Sbjct: 496 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW 555

Query: 553 AFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 587
             ALSSMLC+PL +   + + +GT+ E+ Q LT P
Sbjct: 556 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP 590


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  668 bits (1724), Expect = 0.0
 Identities = 324/580 (55%), Positives = 408/580 (70%), Gaps = 28/580 (4%)

Query: 22  LIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYL 81
           ++ P P  +P         G P      P RE W+ ++DF++S  G  VGLGNVWRFPYL
Sbjct: 17  ILKPSPGKSPGTRPEDEAEGKP------PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYL 70

Query: 82  CYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVI 140
           CYKNGGG FLIPY +     G+P+FFLEI +GQ+   G I  W  ICPLF G+GYAS+VI
Sbjct: 71  CYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVI 130

Query: 141 VFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCA---NASLAN 197
           V   N YYI++LAW  YYL +SF   LPWA C H+WNTP C+E    ++ +     S  N
Sbjct: 131 VSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTN 190

Query: 198 LTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKST 257
            T        SPVIEFWE  VL LS G++ PG+L W++ LCLL  W++ +FC+WKGV+ST
Sbjct: 191 FT--------SPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRST 242

Query: 258 GKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSY 317
           GK+VYFTATFP+ +L+VLLVRG+ LPGA  GI +YL PD ++L  PQVWIDAGTQIFFSY
Sbjct: 243 GKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSY 302

Query: 318 AIGLGALTALGSYNRFNNNCY----------NGTSFFAGFVVFSILGFMAAEQGVHISKV 367
           AI LGA+T+LGSYN++  N Y          +GTSF +GF +FSILGFMA EQGV I+ V
Sbjct: 303 AICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADV 362

Query: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
           AESGPGLAFIAYP+AVT+MP+   W+ LFF MLLLLGLDSQFV VEG IT L+DL P+  
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
              ++REI +A  C++ +++ L+MVT+GGMYVFQLFDYY+ASG  LLW AF+EC V+AW+
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWG 547
           YG D   D I  MIGYRP PWMK+ W+  TP++C+G FIF++V Y PL YN TYVYP W 
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWA 542

Query: 548 EAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 587
             +GW+ ALSSMLCVPL ++  L + +G    R ++L  P
Sbjct: 543 IGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTP 582


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  668 bits (1724), Expect = 0.0
 Identities = 324/580 (55%), Positives = 408/580 (70%), Gaps = 28/580 (4%)

Query: 22  LIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYL 81
           ++ P P  +P         G P      P RE W+ ++DF++S  G  VGLGNVWRFPYL
Sbjct: 17  ILKPSPGKSPGTRPEDEAEGKP------PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYL 70

Query: 82  CYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVI 140
           CYKNGGG FLIPY +     G+P+FFLEI +GQ+   G I  W  ICPLF G+GYAS+VI
Sbjct: 71  CYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVI 130

Query: 141 VFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCA---NASLAN 197
           V   N YYI++LAW  YYL +SF   LPWA C H+WNTP C+E    ++ +     S  N
Sbjct: 131 VSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTN 190

Query: 198 LTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKST 257
            T        SPVIEFWE  VL LS G++ PG+L W++ LCLL  W++ +FC+WKGV+ST
Sbjct: 191 FT--------SPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRST 242

Query: 258 GKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSY 317
           GK+VYFTATFP+ +L+VLLVRG+ LPGA  GI +YL PD ++L  PQVWIDAGTQIFFSY
Sbjct: 243 GKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSY 302

Query: 318 AIGLGALTALGSYNRFNNNCY----------NGTSFFAGFVVFSILGFMAAEQGVHISKV 367
           AI LGA+T+LGSYN++  N Y          +GTSF +GF +FSILGFMA EQGV I+ V
Sbjct: 303 AICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADV 362

Query: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
           AESGPGLAFIAYP+AVT+MP+   W+ LFF MLLLLGLDSQFV VEG IT L+DL P+  
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
              ++REI +A  C++ +++ L+MVT+GGMYVFQLFDYY+ASG  LLW AF+EC V+AW+
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWG 547
           YG D   D I  MIGYRP PWMK+ W+  TP++C+G FIF++V Y PL YN TYVYP W 
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWA 542

Query: 548 EAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 587
             +GW+ ALSSMLCVPL ++  L + +G    R ++L  P
Sbjct: 543 IGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTP 582


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  657 bits (1696), Expect = 0.0
 Identities = 315/574 (54%), Positives = 397/574 (69%), Gaps = 19/574 (3%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY++     GIP+F LE +
Sbjct: 32  RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETA 91

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           LGQ+   G +  W  ICP+F+G+GYAS +IV   N YYI+VLAW  +YL  SFT  LPW 
Sbjct: 92  LGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWG 151

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
            C H WNT  C+E  +     N +  N T        SPVIEFWE +VL++S G++  GA
Sbjct: 152 GCYHEWNTEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGA 203

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA  GI 
Sbjct: 204 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQ 263

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340
           +YL P+ ++L  PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY          +G
Sbjct: 264 FYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 323

Query: 341 TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFML 400
           TSF AGF +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA  FFFM+
Sbjct: 324 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMV 383

Query: 401 LLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVF 460
           +LLGLDSQFV VE  +T L+D+ P  +  + +RE+ +     + F++ L M+T+GGMYVF
Sbjct: 384 VLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVF 443

Query: 461 QLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLV 520
           QLFDYY+ASG  LL+ A +E + VAWVYGA RF D+I  MIGYRP P +K+CW F TP V
Sbjct: 444 QLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAV 503

Query: 521 CMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 580
           C   F+F+++ Y PL YN  Y YPWWG+A+GW  ALSSM+C+P   L  L   KG   ER
Sbjct: 504 CTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 563

Query: 581 WQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSE 614
            + L  P   L         A     T+L  ++E
Sbjct: 564 IRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTE 597


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  651 bits (1680), Expect = 0.0
 Identities = 307/551 (55%), Positives = 393/551 (71%), Gaps = 20/551 (3%)

Query: 49  VPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFL 108
           V  R  WT +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY +   V GIP+FFL
Sbjct: 33  VKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFL 92

Query: 109 EISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTL 167
           E++LGQ+   GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ L
Sbjct: 93  EVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSEL 152

Query: 168 PWATCGHTWNTPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
           PW TC + WNT  C +   H      +   N T        SPV+EFWE +VL ++ G+ 
Sbjct: 153 PWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIH 204

Query: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
             G+L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY-------- 338
            GIIYYLKPD  +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCY        
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 339 --NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 396
             + TSF AGFVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LF
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 397 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGG 456
           F ML+ LGLDSQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 457 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 516
           MY+FQLFDYY++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F 
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 517 TPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGT 576
           TP +C+  F+F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 577 MAERWQHLTQP 587
             +R + L  P
Sbjct: 565 FRKRLRQLITP 575


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  651 bits (1680), Expect = 0.0
 Identities = 307/551 (55%), Positives = 393/551 (71%), Gaps = 20/551 (3%)

Query: 49  VPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFL 108
           V  R  WT +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY +   V GIP+FFL
Sbjct: 33  VKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFL 92

Query: 109 EISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTL 167
           E++LGQ+   GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ L
Sbjct: 93  EVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSEL 152

Query: 168 PWATCGHTWNTPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
           PW TC + WNT  C +   H      +   N T        SPV+EFWE +VL ++ G+ 
Sbjct: 153 PWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIH 204

Query: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
             G+L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY-------- 338
            GIIYYLKPD  +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCY        
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 339 --NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 396
             + TSF AGFVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LF
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 397 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGG 456
           F ML+ LGLDSQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 457 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 516
           MY+FQLFDYY++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F 
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 517 TPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGT 576
           TP +C+  F+F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 577 MAERWQHLTQP 587
             +R + L  P
Sbjct: 565 FRKRLRQLITP 575


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  651 bits (1680), Expect = 0.0
 Identities = 307/551 (55%), Positives = 393/551 (71%), Gaps = 20/551 (3%)

Query: 49  VPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFL 108
           V  R  WT +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY +   V GIP+FFL
Sbjct: 33  VKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFL 92

Query: 109 EISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTL 167
           E++LGQ+   GS+  W  ICPLF+G+G AS+VI  Y N YYI++LAW  +YL  SFT+ L
Sbjct: 93  EVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSEL 152

Query: 168 PWATCGHTWNTPDCVEIFRHEDCANAS-LANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
           PW TC + WNT  C +   H      +   N T        SPV+EFWE +VL ++ G+ 
Sbjct: 153 PWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT--------SPVMEFWERRVLGITSGIH 204

Query: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
             G+L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LV+LL+RGV LPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY-------- 338
            GIIYYLKPD  +L  PQVW+DAGTQIFFS+AI  G LTALGSYN+++NNCY        
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 339 --NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 396
             + TSF AGFVVFSILGFM+ EQGV IS+VAESGPGLAFIA+P+AVT+MP++ LW+ LF
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 397 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGG 456
           F ML+ LGLDSQFV VE  +T  +D+ P       +RE+ +     +C++I L +VT+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 457 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 516
           MY+FQLFDYY++SG  LL+ + +E V ++WVYGADRF D+I  MIGYRP P +K  W F 
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 517 TPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGT 576
           TP +C+  F+F++  Y PL YNN YVYP WG ++GW  ALSSM+CVPL ++  LL+ +G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 577 MAERWQHLTQP 587
             +R + L  P
Sbjct: 565 FRKRLRQLITP 575


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  616 bits (1589), Expect = e-176
 Identities = 292/570 (51%), Positives = 389/570 (68%), Gaps = 28/570 (4%)

Query: 30  APAKGDGPVGLGTPGGRLA--VPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGG 87
           AP   D P  L     + A  +P R+TW  + DF+MSCVG+A+GLGNVWRFPYLC KNGG
Sbjct: 20  APVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGG 79

Query: 88  GVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTY 147
           G FLIPY L  +  G+P+F LE SLGQ+   G + VW + P+FKG+G A+ V+ F+ N Y
Sbjct: 80  GAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIY 139

Query: 148 YIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRR 207
           YI++++W  YYL  SFTTTLPW  C + WNT  C         +N S+ N T     +  
Sbjct: 140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCF--------SNYSMVNTT-----NMT 186

Query: 208 SPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATF 267
           S V+EFWE  + +++ GL+ PG + W + + L   W+LVYFC+WKGV  TGK+VYF+AT+
Sbjct: 187 SAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATY 246

Query: 268 PYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTAL 327
           PY++L++L  RGV LPGA +GI++Y+ P++ KL   +VW+DA TQIFFSY +GLG+L AL
Sbjct: 247 PYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIAL 306

Query: 328 GSYNRFNNNCYNG----------TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFI 377
           GSYN F+NN Y            TS FAGFV+FSI+GFMA      I+ VA SGPGLAF+
Sbjct: 307 GSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFL 366

Query: 378 AYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISV 437
           AYP AVT +P++PLWA LFF MLL+LG+DSQF  VEGFIT L+D  P     R +RE+ +
Sbjct: 367 AYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPR--LLRNRRELFI 424

Query: 438 ALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDI 497
           A  C + ++I LS +T GG+YVF+LFDYYSASG +LL+  F+ECV ++W YG +RF D+I
Sbjct: 425 AAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNI 484

Query: 498 ACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALS 557
             M+G RPC W K CWSFFTP++  G+FIF+ V   PL   N YV+P WG+ +GW  ALS
Sbjct: 485 QEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGN-YVFPKWGQGVGWLMALS 543

Query: 558 SMLCVPLHLLGCLLRAKGTMAERWQHLTQP 587
           SM+ +P ++    L  KG++ +R Q + QP
Sbjct: 544 SMVLIPGYMAYMFLTLKGSLKQRIQVMVQP 573


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  504 bits (1298), Expect = e-143
 Identities = 252/553 (45%), Positives = 347/553 (62%), Gaps = 23/553 (4%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  WT ++DF++SC+G+ VGLGNVWRFPY  Y NGGG FL+PY L+  + GIP+FFLE+S
Sbjct: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
           LGQF   G + VW I PLFKG G A ++IV     YY M++A+  +YL  S T+ LPW  
Sbjct: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156

Query: 172 CGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPG 229
           CG+ WNT  C+E    +D   A   NLTC       SP  E+W   VL + G  G+  PG
Sbjct: 157 CGNWWNTELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPG 211

Query: 230 ALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGI 289
            + W + LCLL  WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA  GI
Sbjct: 212 EIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGI 271

Query: 290 IYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG--------- 340
            +YL P +  L S +VWI+A  QIF+S  +G G L    SYN F+ N Y           
Sbjct: 272 QFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNA 331

Query: 341 -TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFM 399
            TS  AGF +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFM
Sbjct: 332 ITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFM 391

Query: 400 LLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYV 459
           LL LGLDSQF  +E  +T + D  P  YY R ++ +   L C   +++ L + TDGGMY 
Sbjct: 392 LLTLGLDSQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYW 449

Query: 460 FQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPL 519
             L D YSAS   L+      C+ V  VYG  RF  DI  M+G++P  + + CW F +P 
Sbjct: 450 LVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPA 508

Query: 520 VCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAE 579
             + + ++++V Y+P  Y  +Y +P W E +G    L S L +P  +L  +LR +G++ E
Sbjct: 509 TLLALMVYSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWE 567

Query: 580 RWQHLTQPI--WG 590
           R Q  ++P   WG
Sbjct: 568 RLQQASRPAMDWG 580


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  502 bits (1292), Expect = e-142
 Identities = 257/615 (41%), Positives = 371/615 (60%), Gaps = 37/615 (6%)

Query: 13  VSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRET----------WTRQMDFI 62
           +SG + +  +  P      A   GPV   +P    AVP   T          W  Q++F+
Sbjct: 1   MSGGDTRAAIARP----RMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFV 56

Query: 63  MSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSIN 122
           ++ VG+AVGLGNVWRFPYLCY+NGGG F+ PY ++ +  GIP+FF+E+S GQF   G + 
Sbjct: 57  LTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLG 116

Query: 123 VWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCV 182
           VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT DC 
Sbjct: 117 VWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCA 176

Query: 183 EIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235
            +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +   +
Sbjct: 177 GVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPL 236

Query: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295
             CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+YYL P
Sbjct: 237 LGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP 296

Query: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYN----------GTSFFA 345
            W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY            TS +A
Sbjct: 297 QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYA 356

Query: 346 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 405
           GFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+LLGL
Sbjct: 357 GFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGL 416

Query: 406 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465
            +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   L D 
Sbjct: 417 GTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLLLMDN 475

Query: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525
           Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P +   I 
Sbjct: 476 YAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFIL 534

Query: 526 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAERWQHL 584
           +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R ++ 
Sbjct: 535 VFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNA 593

Query: 585 TQPI--WGLHHLEYR 597
           T+P   WG   LE+R
Sbjct: 594 TKPSRDWGPALLEHR 608


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  499 bits (1285), Expect = e-141
 Identities = 248/556 (44%), Positives = 346/556 (62%), Gaps = 22/556 (3%)

Query: 51  PRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEI 110
           PRETW +++DF++S VGFAV L NVWRFPYLCYKNGGG FLIPY L  ++ G+P+F++E+
Sbjct: 55  PRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMEL 114

Query: 111 SLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +LGQ+ + G+  VW ICP FKG+GYA ++I  Y   YY +++AW  YYL  SFT  LPW 
Sbjct: 115 ALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVP 228
            CGHTWN+P+C +        N S+          + +P  EF+E  VL L  S G+   
Sbjct: 175 DCGHTWNSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI 230

Query: 229 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 288
           G   W++ LCL+   +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +G
Sbjct: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290

Query: 289 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG-------- 340
           I  YL  D+ +L    VWIDA TQIFFS   G G L A  SYN+F+NNCY          
Sbjct: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350

Query: 341 --TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFF 398
             TSF +GF +FSILG+MA E  V+I  VA  G GL FI YP A++ +  +  WA +FF 
Sbjct: 351 CITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFV 410

Query: 399 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 458
           MLL LGLDS   G+E  ITGL D        +  R++         F++ L  +T GG+Y
Sbjct: 411 MLLALGLDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIY 467

Query: 459 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 518
           V  L D + A+GT++L+    E + V+W YG DRF +DI  M+G+RP  + + CW F +P
Sbjct: 468 VLTLLDTF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSP 526

Query: 519 LVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMA 578
              + + + +++ ++PL Y++ Y++P W   +GW  ALSSM+ VP++++   L  +G++ 
Sbjct: 527 AFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLW 585

Query: 579 ERWQHLTQPIWGLHHL 594
           ER  +   P    HHL
Sbjct: 586 ERLAYGITP-ENEHHL 600


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  498 bits (1281), Expect = e-141
 Identities = 246/566 (43%), Positives = 355/566 (62%), Gaps = 23/566 (4%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  Q++F+++ VG+AVGLGNVWRFPYLCY+NGGG F+ PY ++ +  GIP+FF+E+S
Sbjct: 27  RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 86

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
            GQF   G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA 
Sbjct: 87  FGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 146

Query: 172 CGHTWNTPDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGG 224
           C + WNT DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  
Sbjct: 147 CNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDD 206

Query: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPG 284
           +   G +   +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L G
Sbjct: 207 IGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEG 266

Query: 285 ALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYN----- 339
           A DGI+YYL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY      
Sbjct: 267 AFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVII 326

Query: 340 -----GTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAA 394
                 TS +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ 
Sbjct: 327 SITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSL 386

Query: 395 LFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTD 454
           LFFFML+LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + + 
Sbjct: 387 LFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQ 445

Query: 455 GGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWS 514
            G+Y   L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW 
Sbjct: 446 AGIYWLLLMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 504

Query: 515 FFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAK 574
           F +P +   I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  
Sbjct: 505 FVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTD 563

Query: 575 G-TMAERWQHLTQPI--WGLHHLEYR 597
           G T+ +R ++ T+P   WG   LE+R
Sbjct: 564 GDTLLQRLKNATKPSRDWGPALLEHR 589


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  498 bits (1281), Expect = e-141
 Identities = 246/566 (43%), Positives = 355/566 (62%), Gaps = 23/566 (4%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  Q++F+++ VG+AVGLGNVWRFPYLCY+NGGG F+ PY ++ +  GIP+FF+E+S
Sbjct: 100 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 159

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
            GQF   G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA 
Sbjct: 160 FGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 219

Query: 172 CGHTWNTPDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGG 224
           C + WNT DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  
Sbjct: 220 CNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDD 279

Query: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPG 284
           +   G +   +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L G
Sbjct: 280 IGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEG 339

Query: 285 ALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYN----- 339
           A DGI+YYL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY      
Sbjct: 340 AFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVII 399

Query: 340 -----GTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAA 394
                 TS +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ 
Sbjct: 400 SITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSL 459

Query: 395 LFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTD 454
           LFFFML+LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + + 
Sbjct: 460 LFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQ 518

Query: 455 GGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWS 514
            G+Y   L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW 
Sbjct: 519 AGIYWLLLMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 577

Query: 515 FFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAK 574
           F +P +   I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  
Sbjct: 578 FVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTD 636

Query: 575 G-TMAERWQHLTQPI--WGLHHLEYR 597
           G T+ +R ++ T+P   WG   LE+R
Sbjct: 637 GDTLLQRLKNATKPSRDWGPALLEHR 662


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  497 bits (1280), Expect = e-140
 Identities = 252/599 (42%), Positives = 357/599 (59%), Gaps = 42/599 (7%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W+ ++DFI+S VG+AVGLGNVWRFPYL ++NGGG FLIPY+++  + G+PIFFLE+S
Sbjct: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
           LGQF   G ++VW   P  +G G A ++I      YY +++ +  +YL  SF + LPW +
Sbjct: 251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGS 310

Query: 172 CGHTWNTPDC------------------VEIFRHEDC----ANASLANLTCDQLADRRSP 209
           C + WNTP+C                  ++I     C     N ++ N T        S 
Sbjct: 311 CNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370

Query: 210 VIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPY 269
             E+++  VL++S G+E PG + W + LCL   WV+VY  + KG+K++GK+VYFTATFPY
Sbjct: 371 SEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPY 430

Query: 270 VVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGS 329
           VVLV+LL+RGV LPGA  GI Y++ P W KL    VW DA TQIFFS +   G L  L S
Sbjct: 431 VVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSS 490

Query: 330 YNRFNNNCY----------NGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAY 379
           YN+F+NNCY          + TS FAGFV+FS++GFMA E+ V+I  VA+ GPG+AF+ Y
Sbjct: 491 YNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVY 550

Query: 380 PRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVAL 439
           P A+T +P++P WA +FF MLL LGLD+ F  +E  +T + D  P   Y R  + +    
Sbjct: 551 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPK--YLRTHKPVFTLG 608

Query: 440 CCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIAC 499
           CC   F++   M+T GG+Y+FQL D Y+AS   L+  A +E V +++VYG  RF +DI  
Sbjct: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEM 667

Query: 500 MIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSM 559
           MIG++P  + K CW+F TP +   I  F+   +EP+ Y  +Y YP W   +GW     S+
Sbjct: 668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY-GSYRYPNWSMVLGWLMLACSV 726

Query: 560 LCVPLHLLGCLLRAKGTMAERWQHL--TQPIWGLHHLEYRAQDADVRGLTTLTPVSESS 616
           + +P+  +  +  A G   ER + +   QP WG     + AQ    R    + P+  SS
Sbjct: 727 IWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWG----PFLAQHRGERYKNMIDPLGTSS 781


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  487 bits (1254), Expect = e-137
 Identities = 238/548 (43%), Positives = 338/548 (61%), Gaps = 22/548 (4%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           RETW +++DF++S +GFAV L NVWRFPYLCYKNGGG FL+PY+L  ++ G+P+F++E++
Sbjct: 60  RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 119

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
           LGQF + G+  VW ICP+ KG+G+  ++I  Y   +Y +++AW  +YL  SFTT LPW  
Sbjct: 120 LGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIH 179

Query: 172 CGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPG 229
           C ++WN+P+C +    +   ++S  N T        +P  E++E  VL L  S G++  G
Sbjct: 180 CNNSWNSPNCSDAHPGDSSGDSSGLNDTFG-----TTPAAEYFERGVLHLHQSHGIDDLG 234

Query: 230 ALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGI 289
              W++T CL+   VL+YF +WKGVK++GK+V+ TAT PYVVL  LL+RGV LPGA+DGI
Sbjct: 235 PPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294

Query: 290 IYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG--------- 340
             YL  D+ +L    VWIDA TQ+ FS  +G G L A  SYN+F NNCY           
Sbjct: 295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINS 354

Query: 341 -TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFM 399
            TSF +GFVVFS LG+MA +  V I  VA+ GPGL FI YP A+  +P++  WA +FF M
Sbjct: 355 LTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIM 414

Query: 400 LLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYV 459
           LL LG+DS   G+E  ITGL+D     +     RE+         F++ L  VT+GG+YV
Sbjct: 415 LLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLATFLLSLFCVTNGGIYV 471

Query: 460 FQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPL 519
           F L D++ A+GT++L+    E + VAW YG  +F DDI  M G RP  + + CW   +P 
Sbjct: 472 FTLLDHF-AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPC 530

Query: 520 VCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAE 579
             + + + ++V + P  Y   Y++P W  A+GW  A SSM  VP++         G+  E
Sbjct: 531 FLLFVVVVSIVTFRPPHY-GAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFRE 589

Query: 580 RWQHLTQP 587
           +  +   P
Sbjct: 590 KLAYAIAP 597


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  483 bits (1244), Expect = e-136
 Identities = 250/599 (41%), Positives = 360/599 (60%), Gaps = 39/599 (6%)

Query: 7   ENGIYS----VSGDEKKGPLIAPGPDGAPAKGDG-------PVGLGTPGGRLAVPPRETW 55
           ENG+        GD+ +   I+ G    P+ G G       P    T    L    RETW
Sbjct: 23  ENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETW 82

Query: 56  TRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQF 115
            +++DF++S +G+AV LGNVWRFPY+CY+NGGG FL+PY ++A+ GGIP+F++E++LGQ+
Sbjct: 83  GKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142

Query: 116 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 174
            + G I++W  ICP+FKG+GYA  +I FY  +YY  ++AW  YYL+ SFT  LPW +C +
Sbjct: 143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKN 202

Query: 175 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALN 232
           +WNT +C   F  +        N+T        SP  EF+   VL++  S GL+  G ++
Sbjct: 203 SWNTGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252

Query: 233 WEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYY 292
           W++ LC++  + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG  LPGA  G+++Y
Sbjct: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312

Query: 293 LKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG----------TS 342
           LKP+W KL    VWIDA  QIFFS   G G L A  SYN+FNNNCY            TS
Sbjct: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372

Query: 343 FFAGFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 401
           F +GFV+F++LG+MA  +   +S+VA ++GP L FI Y  A+  MP +  +A +FF ML+
Sbjct: 373 FVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLI 432

Query: 402 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 461
            LGLDS F G+EG IT +LD  P  + +  +RE  V      CF   L  +T GG YV +
Sbjct: 433 TLGLDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVK 490

Query: 462 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 521
           L + Y A+G  +L  A  E V V+W YG  +F  D+  M+G+ P  + + CW   +PL  
Sbjct: 491 LLEEY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL 549

Query: 522 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 580
           + I I + +   P +    Y YP+W   +G+    SS +C+P ++   L+   GT  ER
Sbjct: 550 LFI-ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  440 bits (1131), Expect = e-123
 Identities = 233/589 (39%), Positives = 346/589 (58%), Gaps = 49/589 (8%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W+++ D+++S +G+AVGLGNVWRFPYL Y NGGG FLIPY ++  + G+P+FFLE S
Sbjct: 36  RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECS 95

Query: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171
           LGQF   G ++VW I PLF+G+G   ++I  +   YY +++A+  YY+  SF + LPW  
Sbjct: 96  LGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKN 155

Query: 172 CGHTWNTPDCVE--IFRHEDCANAS---------------LANLTC----DQLADRRSPV 210
           C  +W+  +C    I  H + +  +               + N TC    +     + P 
Sbjct: 156 CS-SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPS 214

Query: 211 IEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYV 270
            ++W    L+ S G+   G + W + LCLL  W++V   ++KG+KS+GK+VYFTA FPYV
Sbjct: 215 EQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYV 274

Query: 271 VLVVLLVRGVLLPGALDGIIYYL--KPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALG 328
           VL++LLVRG  L GA  GI YY+  + +++KL   +VW DA TQIF+S ++  G L AL 
Sbjct: 275 VLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALS 334

Query: 329 SYNRFNNNCYNG----------TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIA 378
           SYN+F NNC++           TS FAGF +FSILG MA   G  +S+V +SG  LAFIA
Sbjct: 335 SYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIA 394

Query: 379 YPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVA 438
           YP A+  +P  P W+ LFFFMLL LGLDSQF  +E   T + DL P     +  +++ V 
Sbjct: 395 YPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFP-----KVMKKMRVP 449

Query: 439 L---CCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMD 495
           +   CC + F++ L  VT  G+Y   L D++ A G  +L  A  E V + W+YG +RF++
Sbjct: 450 ITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCA-GWGILIAAILELVGIIWIYGGNRFIE 508

Query: 496 DIACMIG-YRPCPWMKW--CWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGW 552
           D   MIG  R   W+ W  CW   TP++ + IFI+++V +    Y     YP WG A+GW
Sbjct: 509 DTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNY-GAIPYPDWGVALGW 567

Query: 553 AFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPI--WGLHHLEYRAQ 599
              +  ++ +P+  +  +++AKG + +R     +P   WG +  ++R +
Sbjct: 568 CMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGE 616


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  361 bits (926), Expect = 1e-99
 Identities = 218/609 (35%), Positives = 306/609 (50%), Gaps = 105/609 (17%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  +  +++SC GFAVGLGN+WRFPYLC   GGG FLIPYV+  +  GIPIF +E++
Sbjct: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ ++ GS+ VW  I P   G+G   + + F  + YY  ++AW  +YL+ SF   LPW+
Sbjct: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
           +C    N    VE     +C  +S  +               FW  + L ++  +   G+
Sbjct: 138 SCPPDLNRTGFVE-----ECQGSSAVSY--------------FWYRQTLNITADINDSGS 178

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           + W + +CL A W +VY CV +G+++TGK++YFTA FPY+VL + L+RG+ LPGA  G+I
Sbjct: 179 IQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLI 238

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---------- 340
           Y   P+   L +P+VW+DA TQIFFS ++  G   A  SYN   N+C             
Sbjct: 239 YLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRM 298

Query: 341 TSFFAGFVVFSILGFMAAEQGVHI------------------------------------ 364
           TS +A   VFS+LGF A     H                                     
Sbjct: 299 TSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWP 358

Query: 365 SKVAE----------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQ 408
            +VA+                SGPGLAF+ +      MP AP+WA LFF ML  LGL + 
Sbjct: 359 KRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTM 418

Query: 409 FVGVEGFITGLLD--LLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466
           F  VE  IT LLD  +LP        +E    L C +CF+         G Y  ++FD +
Sbjct: 419 FGTVEAVITPLLDVGVLPR----WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNF 474

Query: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526
           +AS   LL  AF E V V +VYG  RF DDIA M G RP P+ +  W   +PL+ + IF+
Sbjct: 475 AAS-PNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFV 532

Query: 527 FNVV--YYEPLVY---NNTY---------VYPWWGEAMGWAFALSSMLCVPLHLLGCLL- 571
             ++  +++PL Y   N  Y         +YP W  A     +L  +L VP+  L  LL 
Sbjct: 533 AYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLT 592

Query: 572 RAKGTMAER 580
           R + T  +R
Sbjct: 593 RRRRTWRDR 601


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  350 bits (899), Expect = 2e-96
 Identities = 208/603 (34%), Positives = 297/603 (49%), Gaps = 105/603 (17%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W   + F+ +C+ +AVGLGNVWRFPYLC   GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
            C    N          E+C  AS                  FW  K L +S  L+  G 
Sbjct: 125 VCPLNGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGG 165

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           + WE  LCLL  W++VY C+ +G +STGK+VYFTA+ PY VL++ L+RG+ L GA +G++
Sbjct: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLM 225

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340
           Y   P   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC           + 
Sbjct: 226 YMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 285

Query: 341 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 364
           TS FA  V FSI GF A                     E G                 + 
Sbjct: 286 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 345

Query: 365 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 406
           SK +E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ 
Sbjct: 346 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 405

Query: 407 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466
           S        +T L D    S +    +E    L C +   I +    + G Y F +F+ Y
Sbjct: 406 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 463

Query: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526
           +A+  +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+
Sbjct: 464 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 522

Query: 527 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 571
           F   Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  +
Sbjct: 523 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579

Query: 572 RAK 574
           + +
Sbjct: 580 QRR 582


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  345 bits (885), Expect = 7e-95
 Identities = 191/542 (35%), Positives = 281/542 (51%), Gaps = 91/542 (16%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  +  ++++C+GF VGLGNVWRFPYLC  +GGG F+IP++++ ++ GIP+ +LE +
Sbjct: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ ++ GS+ VW+ I P  KGLG ASM+  F    YY  +++W  +YL  SF   LPW+
Sbjct: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
            C    N    V+     +CA              R SPV  FW  + L +S  +   G+
Sbjct: 152 DCPLNENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGS 192

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           + W + LCL   W ++Y C  +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI+
Sbjct: 193 IQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIV 252

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNC---------YNG- 340
           +   P+ ++L  P  W+DAG Q+FFS+++  G L +  SYN  +NNC          NG 
Sbjct: 253 FLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGF 312

Query: 341 TSFFAGFVVFSILG---------------------------------------------- 354
           TS +   VV+S++G                                              
Sbjct: 313 TSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDP 372

Query: 355 -------FMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 407
                  F   +    +S+  E G GLAFI +  A+T MP++PLW+ LFF ML  LGL S
Sbjct: 373 AAYAQLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431

Query: 408 QFVGVEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465
            F  +EG +  L DL  +P     ++ +E+   L C   F+I      + G Y   L D 
Sbjct: 432 MFGNMEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487

Query: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525
           Y+ S   LL  AF E   V +VYG DRF  DI  MIG++P  + +  W   +PL+ + IF
Sbjct: 488 YAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIF 546

Query: 526 IF 527
           +F
Sbjct: 547 LF 548


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  294 bits (752), Expect = 2e-79
 Identities = 191/603 (31%), Positives = 271/603 (44%), Gaps = 142/603 (23%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W   + F+ +C+ +AVGLGNVWRFPYLC   GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ M+ GSI  W  I P   G+G AS+V+ F+ + YY ++ AW F+YL  SF   LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
            C    N          E+C  AS                  FW  K L +S  L+  G 
Sbjct: 125 VCPLNGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGG 165

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           + WE  LCLL  W++VY C+ +G +STGKI                              
Sbjct: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------------ 195

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340
                   +L +P+ WI+A TQIFFS  +G G+L A  SYN  +NNC           + 
Sbjct: 196 -------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 248

Query: 341 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 364
           TS FA  V FSI GF A                     E G                 + 
Sbjct: 249 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 308

Query: 365 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 406
           SK +E                   G GLAFI Y  A+  M V+ LW+ L+FFMLL+LG+ 
Sbjct: 309 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 368

Query: 407 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466
           S        +T L D    S +    +E    L C +   I +    + G Y F +F+ Y
Sbjct: 369 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 426

Query: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526
           +A+  +LL     E + V +VYG  RF  D+  M G     + K  W+  +PL+ + +F+
Sbjct: 427 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 485

Query: 527 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 571
           F   Y    +   T  Y  W  + G        A+AL        SS +C+PL  LG  +
Sbjct: 486 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542

Query: 572 RAK 574
           + +
Sbjct: 543 QRR 545


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  277 bits (708), Expect = 2e-74
 Identities = 131/317 (41%), Positives = 198/317 (62%), Gaps = 28/317 (8%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  ++ +I++ +GF+VGLGN+WRFPYLC KNGGG +L+PY+++ ++ GIP+FFLE++
Sbjct: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ ++ GSI VW+ ICP   G+G++S ++  +   YY +++ W  +Y  KSF   LPW+
Sbjct: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179

Query: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
            C           + R     N S+A +  +   ++ S    FW  + L +S  +   G 
Sbjct: 180 EC----------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGG 222

Query: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
           LNW++TLCLL  W +V   V KG++S+GK++YF++ FPYVVL   LVRG+LL GA+DGI+
Sbjct: 223 LNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGIL 282

Query: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---------- 340
           +   P   K+  PQVW +A TQ+FF+  +G G + A  SYN+ +NNC+            
Sbjct: 283 HMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFF 342

Query: 341 TSFFAGFVVFSILGFMA 357
           TS  A  VVF++LGF A
Sbjct: 343 TSVLATLVVFAVLGFKA 359



 Score =  106 bits (265), Expect = 6e-23
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 371 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 430
           G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S    + G  T ++D       F+
Sbjct: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490

Query: 431 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 490
             +E+    CC   F++ L  V   G Y   +FD YSA+   L      E + VAW+YG 
Sbjct: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549

Query: 491 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 524
            +FM ++  M+G+RP  +  + W F +PL CM +
Sbjct: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  273 bits (697), Expect = 5e-73
 Identities = 131/323 (40%), Positives = 194/323 (60%), Gaps = 40/323 (12%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  ++ +I++ VGF+VGLGNVWRFPYLC KNGGG +L+PY+++ +V GIP+FFLE+S
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW 
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 171 TC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGG 224
            C       HT+  P+C                       ++ S    +W  + L +S  
Sbjct: 181 QCPLVKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSS 217

Query: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPG 284
           +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G
Sbjct: 218 ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNG 277

Query: 285 ALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---- 340
           ++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+      
Sbjct: 278 SIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLV 337

Query: 341 ------TSFFAGFVVFSILGFMA 357
                 TS  A  VVF++LGF A
Sbjct: 338 SFINFFTSVLATLVVFAVLGFKA 360



 Score =  125 bits (315), Expect = 9e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489

Query: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547

Query: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 536
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607

Query: 537 YNNTYVYPWWGEAMGWAFALSSMLCVPL 564
                 YP WG  +  +  + ++L VP+
Sbjct: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  205 bits (522), Expect = 9e-53
 Identities = 104/276 (37%), Positives = 156/276 (56%), Gaps = 40/276 (14%)

Query: 99  LVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFY 157
           +V GIP+FFLE+S+GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 158 YLVKSFTTTLPWATC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVI 211
           Y  +SF   LPW  C       HT+  P+C                       ++ S   
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPEC-----------------------EQSSATT 97

Query: 212 EFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVV 271
            +W  + L +S  +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVV
Sbjct: 98  YYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVV 157

Query: 272 LVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYN 331
           L+  L+R  LL G++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN
Sbjct: 158 LICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYN 217

Query: 332 RFNNNCYNG----------TSFFAGFVVFSILGFMA 357
           + +NNC+            TS  A  VVF++LGF A
Sbjct: 218 KRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 253



 Score =  125 bits (315), Expect = 9e-29
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382

Query: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 383 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440

Query: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 536
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500

Query: 537 YNNTYVYPWWGEAMGWAFALSSMLCVPL 564
                 YP WG  +  +  + ++L VP+
Sbjct: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPV 528


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  196 bits (499), Expect = 4e-50
 Identities = 97/198 (48%), Positives = 120/198 (60%), Gaps = 18/198 (9%)

Query: 22  LIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYL 81
           ++ P P  +P         G P      P RE W+ ++DF++S  G  VGLGNVWRFPYL
Sbjct: 17  ILKPSPGKSPGTRPEDEAEGKP------PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYL 70

Query: 82  CYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVW-NICPLFKGLGYASMVI 140
           CYKNGGG FLIPY +     G+P+FFLEI +GQ+   G I  W  ICPLF G+GYAS+VI
Sbjct: 71  CYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVI 130

Query: 141 VFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCA---NASLAN 197
           V   N YYI++LAW  YYL +SF   LPWA C H+WNTP C+E    ++ +     S  N
Sbjct: 131 VSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTN 190

Query: 198 LTCDQLADRRSPVIEFWE 215
            T        SPVIEFWE
Sbjct: 191 FT--------SPVIEFWE 200


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  189 bits (481), Expect = 5e-48
 Identities = 88/232 (37%), Positives = 139/232 (59%), Gaps = 33/232 (14%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W  ++ +I++ VGF+VGLGNVWRFPYLC KNGGG +L+PY+++ +V GIP+FFLE+S
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
           +GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW 
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 171 TC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGG 224
            C       HT+  P+C                       ++ S    +W  + L +S  
Sbjct: 181 QCPLVKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSS 217

Query: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL 276
           +   G LNW++T+CLLA WV+V   + KG++S+GK+   +   P+++L++ +
Sbjct: 218 ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLITI 266


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  164 bits (416), Expect = 2e-40
 Identities = 93/309 (30%), Positives = 156/309 (50%), Gaps = 28/309 (9%)

Query: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
           R  W+ + ++I++ VGF++    +WRF YL   +GG  F   Y+ +  + G+P+ FLE++
Sbjct: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162

Query: 112 LGQFMKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
            GQ M+ G + VW I  P   G+GY+S ++ F    Y+ +V +W  +Y+ +SF   +PW 
Sbjct: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222

Query: 171 TCGHTWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
            C  T N+    P+C                       +R +P I FW  + L+ S  +E
Sbjct: 223 KCPLTMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIE 259

Query: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
             G+  + + L    CW LV   +  G+KSTGK++Y     P  ++V   +R +LL GA 
Sbjct: 260 DGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAK 319

Query: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAG 346
            G+   +    S + +  VW  AG Q+  +  IGLG++ +L SY   +NNC +     + 
Sbjct: 320 FGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSV 379

Query: 347 FVVFSILGF 355
             + ++L F
Sbjct: 380 INLLTLLVF 388



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 52/172 (30%), Positives = 85/172 (49%), Gaps = 6/172 (3%)

Query: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
           A  GP  AF+++  A++ +P +  W+ +FF MLL +GL S    ++G IT L D      
Sbjct: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS--- 529

Query: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
           +FR   ++ +     L FV  L      G Y  +L   Y      ++   F E + V+W 
Sbjct: 530 FFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF-ETMAVSWA 588

Query: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVY--YEPLVY 537
           YGA RF+ D+  ++G+   P   W W    P+V + IF+  +V+   +P+ Y
Sbjct: 589 YGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITY 640


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.143    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,170,776
Number of Sequences: 37866
Number of extensions: 1203565
Number of successful extensions: 4660
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4374
Number of HSP's gapped (non-prelim): 170
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.