Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 217416347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217416347 cask-interacting protein 2 isoform a [Homo
sapiens]
(1202 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 2435 0.0
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] 2281 0.0
gi|18079216 CASK interacting protein 1 [Homo sapiens] 884 0.0
gi|50511945 cajalin 2 isoform a [Homo sapiens] 213 7e-55
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 208 3e-53
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 133 1e-30
gi|163965366 nascent polypeptide-associated complex alpha subuni... 125 2e-28
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 123 1e-27
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 123 1e-27
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 123 1e-27
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 123 1e-27
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 123 1e-27
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 121 3e-27
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 117 7e-26
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 117 9e-26
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 117 9e-26
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 117 9e-26
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 117 9e-26
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 115 2e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 115 3e-25
gi|160707881 formin 2 [Homo sapiens] 115 3e-25
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 114 7e-25
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 110 8e-24
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 110 1e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 108 3e-23
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 108 4e-23
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 108 4e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 106 1e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 106 1e-22
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 105 2e-22
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 2435 bits (6310), Expect = 0.0
Identities = 1202/1202 (100%), Positives = 1202/1202 (100%)
Query: 1 MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG 60
MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG
Sbjct: 1 MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG 60
Query: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH
Sbjct: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
Query: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE 180
LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE
Sbjct: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE 180
Query: 181 AKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLL 240
AKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLL
Sbjct: 181 AKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLL 240
Query: 241 LEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA 300
LEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA
Sbjct: 241 LEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA 300
Query: 301 LNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP 360
LNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP
Sbjct: 301 LNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP 360
Query: 361 TPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQ 420
TPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQ
Sbjct: 361 TPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQ 420
Query: 421 SSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDV 480
SSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDV
Sbjct: 421 SSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDV 480
Query: 481 RPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRK 540
RPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRK
Sbjct: 481 RPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRK 540
Query: 541 KIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQE 600
KIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQE
Sbjct: 541 KIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQE 600
Query: 601 IGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATA 660
IGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATA
Sbjct: 601 IGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATA 660
Query: 661 GPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPS 720
GPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPS
Sbjct: 661 GPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPS 720
Query: 721 GGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSY 780
GGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSY
Sbjct: 721 GGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSY 780
Query: 781 LAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVR 840
LAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVR
Sbjct: 781 LAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVR 840
Query: 841 TSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT 900
TSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT
Sbjct: 841 TSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT 900
Query: 901 GPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTI 960
GPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTI
Sbjct: 901 GPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTI 960
Query: 961 KQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA 1020
KQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA
Sbjct: 961 KQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA 1020
Query: 1021 PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWN 1080
PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWN
Sbjct: 1021 PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWN 1080
Query: 1081 GETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1140
GETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG
Sbjct: 1081 GETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1140
Query: 1141 PGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAM 1200
PGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAM
Sbjct: 1141 PGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAM 1200
Query: 1201 LD 1202
LD
Sbjct: 1201 LD 1202
>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
Length = 1120
Score = 2281 bits (5910), Expect = 0.0
Identities = 1120/1120 (100%), Positives = 1120/1120 (100%)
Query: 83 MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 142
MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC
Sbjct: 1 MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
Query: 143 LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 202
LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR
Sbjct: 61 LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
Query: 203 EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262
EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN
Sbjct: 121 EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
Query: 263 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 322
QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG
Sbjct: 181 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
Query: 323 HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 382
HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL
Sbjct: 241 HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300
Query: 383 TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 442
TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS
Sbjct: 301 TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 360
Query: 443 AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 502
AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ
Sbjct: 361 AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 420
Query: 503 LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 562
LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD
Sbjct: 421 LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 480
Query: 563 LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 622
LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL
Sbjct: 481 LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 540
Query: 623 RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 682
RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG
Sbjct: 541 RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 600
Query: 683 GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 742
GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL
Sbjct: 601 GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 660
Query: 743 CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 802
CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS
Sbjct: 661 CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 720
Query: 803 RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 862
RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR
Sbjct: 721 RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 780
Query: 863 ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 922
ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP
Sbjct: 781 ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 840
Query: 923 AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 982
AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF
Sbjct: 841 AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900
Query: 983 NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 1042
NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS
Sbjct: 901 NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 960
Query: 1043 SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1102
SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP
Sbjct: 961 SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1020
Query: 1103 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1162
KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA
Sbjct: 1021 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1080
Query: 1163 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1202
EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD
Sbjct: 1081 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1120
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 884 bits (2283), Expect = 0.0
Identities = 623/1478 (42%), Positives = 777/1478 (52%), Gaps = 323/1478 (21%)
Query: 1 MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG 60
MG+EQ+L+ AVK DV Q+L+ + + K KLLGSTK++NVN+QD DGFSALHHAAL G
Sbjct: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNG 60
Query: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
+ ELI+LLLEAQA VDIKD+ GMRPLHYAAWQGR EP++L+L+A +AVN S +G IPLH
Sbjct: 61 NTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLH 120
Query: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE 180
LAAQ+GHY+VSEMLLQHQSNPC+V+ + KTPLDLACEFGR+ V QLLL+S++C ALLE
Sbjct: 121 LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPR 180
Query: 181 AKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLL 240
D DPN T+PLHLAAKNGH ++IR LL+AGI+INRQTK+GTALHEAAL GKTEVVRLL
Sbjct: 181 PGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLL 240
Query: 241 LEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA 300
L+ G++ ++RNTY+QTALDIV+QFTTSQASREIKQLLREAS L+VRA KD+ N +D T+
Sbjct: 241 LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTS 300
Query: 301 LNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP 360
LNV+AGD+ITVLEQHPDGRWKG IH+++ G DR+GYFP + E + KR G A PS P
Sbjct: 301 LNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLP 360
Query: 361 TPLRPGFSRTPQPPAEEPPHPLTYSQLPRVG----LSPDSPAGDRNSVGSEGSVGS--IR 414
S + P A PP + + P G S AG R S G GS ++
Sbjct: 361 QG-----SSSSGPSA--PPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVK 413
Query: 415 SAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQ 474
+ S + + GPG ++ P G V P + A + GEQ
Sbjct: 414 LLATVLSQKSVSESGPG----DSPAKPPEGSAGVARSQPPVAHAGQV---------YGEQ 460
Query: 475 IFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVT 534
+ E EGK ++A+ WL+ FQL+ Y +F+ AGYD+PTISRMTPEDLTAIGVT
Sbjct: 461 ---PPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVT 517
Query: 535 KPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLT 594
KPGHRKKIA+EI+ LSI +WLP + P +L WL +GL QY+K LV +GY+++ + D+T
Sbjct: 518 KPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDIT 577
Query: 595 WEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENG 654
WE+LQEIG+ KLGHQKKLML V++LAEL++ A EGG K P+ + + +E+
Sbjct: 578 WEDLQEIGITKLGHQKKLMLAVRKLAELQKA---EYAKYEGGPLRRKAPQSLEVMAIESP 634
Query: 655 EGPATA-----GPRLLTFQGSELSPELQAAMAGG---GPEP-------LPLPPARSPSQE 699
P P++ TFQ SELS ELQAAM G GP P P A +
Sbjct: 635 PPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDS 694
Query: 700 SIGARSRGSGHSQEQPAPQPSGGDPSPPQERN----LPEGTE--RPP------------K 741
S+G R+R SQE P G PS P R+ L EG PP K
Sbjct: 695 SLGGRARHMSSSQELLGDGPPG--PSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIK 752
Query: 742 LCSSLPGQGPPPYV-------FMYPQ-------------GSPSSPAPG-----------P 770
S P G P V F PQ G P PAP P
Sbjct: 753 RASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLP 812
Query: 771 PPGAPWA------------FSYL--------AGP----PATPP----------------D 790
P P + F+Y+ GP PA PP +
Sbjct: 813 PTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAE 872
Query: 791 PPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPA 850
P RPK+R+HSL+R ++ + E + E V + G YAT+ RR GRS VR
Sbjct: 873 PGRPKKRAHSLNRYAASDSEPERD-ELLVPAAAGPYATVQRRVGRSHSVRAPAGAD---- 927
Query: 851 RGTPRSQSFALRARRKGPPPPPPKRLSSV---SGPSPEPPPLDESPGPKEGATGPRR--R 905
+ RSQSFA+R R+KGPPPPPPKR SS + + EP P E P++G G R R
Sbjct: 928 KNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAE---PEDGLLGVRAQCR 984
Query: 906 TLSEPAG-------------------------------PSEPPGPPAPAGP--------- 925
S+ AG P E P PA P
Sbjct: 985 RASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVL 1044
Query: 926 ASDTEEEEPGPEGTPPSR-------------------GSSGEGLPFAEEGNLTIKQRPKP 966
AS +E GP G +R G S + PF E+G T +QRP+
Sbjct: 1045 ASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDG--TGRQRPR- 1101
Query: 967 AGPPPRETPV--PP----------------------GLDFNLTESDTVKRRPKCRERE-- 1000
GP E V PP + F LTESDTVKRRPK +ERE
Sbjct: 1102 -GPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAG 1160
Query: 1001 -----PLQ-----TALLAFGVASATPGPAAPLPSPTPGESPP---ASSLPQPEPSSLPAQ 1047
PL T + AS GP P P P E PP A P P P +
Sbjct: 1161 PEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARK 1220
Query: 1048 GVPTPLAPSPAMQPPVP-------------PCPGPGLESSAASRWNGETEPPAAPAALLK 1094
P++P P + PVP P PGPG S R +G T PP +P K
Sbjct: 1221 PAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPG--SPEVKRAHG-TPPPVSP----K 1273
Query: 1095 VPGAGTAPKPV-SVACTQLAFSGPKLA------------------PRLGPRPVPPPRPES 1135
P TAPKPV +VA +GP A P LG P PP P +
Sbjct: 1274 PPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGA 1333
Query: 1136 TGT--------------------------VGPG-QAQQRLEQTSSSLAAALRAAEKSIGT 1168
PG A+Q+LE+TS+ LAAAL+A E+ I
Sbjct: 1334 PALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQ 1393
Query: 1169 KEQEG----TPSASTKHILDDISTMFDALADQLDAMLD 1202
++ +G ST ILDDI +MFD LADQLDAML+
Sbjct: 1394 EDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE 1431
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 213 bits (543), Expect = 7e-55
Identities = 116/292 (39%), Positives = 188/292 (64%), Gaps = 22/292 (7%)
Query: 1 MGREQDLILAVKNGDVTGVQKLVAKVKA----------TKTKLLGSTKRLNVNYQDADGF 50
MG++Q+L+ A + G+V V+KL++ K + LL + NVN D+ G+
Sbjct: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
Query: 51 SALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR---ASAA 107
+ALHHAAL G +++ LL+ +A+ ++ D+ G P+H AAW+G +E V++L+ + +
Sbjct: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
VN + + + LH AAQYGH EV +LL+ ++P + N +TPLDLA +GRL+V +++
Sbjct: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHE 227
+++H + C+ TPLHLAA+NGH+ V++ LL AG++++ QT+ G+ALHE
Sbjct: 181 ISAHPNLM--------SCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE 232
Query: 228 AALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLRE 279
AAL+GK +VVR+LLE G+D NI+++ +T LDI+ + SQ S +I LL+E
Sbjct: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH-PSQKSLQIATLLQE 283
Score = 62.4 bits (150), Expect = 3e-09
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 492 QAIHNWLSEFQLEGYTAHFLQAGYDVPTI---SRMTPEDLTAIGVTKPGHRKKIASEIAQ 548
Q + WL L Y H + G+D + M +DL IG+ GHR++I I
Sbjct: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872
Query: 549 LSIAEWL--PSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVN 604
L + Y PT + EWL ++ L Y K + +GY SM L+ + WE + + +N
Sbjct: 873 LPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLKIN 931
Query: 605 KLGHQKKLM 613
+GH+K+++
Sbjct: 932 LIGHRKRIL 940
Score = 45.4 bits (106), Expect = 3e-04
Identities = 19/61 (31%), Positives = 40/61 (65%), Gaps = 2/61 (3%)
Query: 565 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 622
+WL ++GLPQY L+++G+D++ + E+ L EIG+ GH+++++ ++ L ++
Sbjct: 817 QWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKM 876
Query: 623 R 623
R
Sbjct: 877 R 877
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 208 bits (529), Expect = 3e-53
Identities = 121/313 (38%), Positives = 182/313 (58%), Gaps = 43/313 (13%)
Query: 1 MGREQDLILAVKNGDVTGVQKLVAKVKATK------------------------------ 30
MG+EQ+L+ A + G + V+KL++ + +
Sbjct: 1 MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
Query: 31 -TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYA 89
+ LL + NVN D+ G++ LHHAAL G +++ +LL A ++ DS G PLH A
Sbjct: 61 LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
Query: 90 AWQGRLEPVRLLLRASAA---VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNK 146
AW+G + VRLL+ + VN + D + LH AAQYGH EV ++LL+ ++P + N
Sbjct: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
Query: 147 AKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIR 206
+TPLDLA +GRL+V ++LLN+H + C+ TPLHLAA+NGH+ V++
Sbjct: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLL--------SCNTKKHTPLHLAARNGHKAVVQ 232
Query: 207 QLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
LL AG++ N QT+ G+ALHEAAL+GKT+VV++LL G DVNI++ + TALD V +
Sbjct: 233 VLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL-P 291
Query: 267 SQASREIKQLLRE 279
SQ S++I L+ +
Sbjct: 292 SQKSQQIAALIED 304
Score = 61.2 bits (147), Expect = 6e-09
Identities = 83/337 (24%), Positives = 125/337 (37%), Gaps = 45/337 (13%)
Query: 297 DPTALNVRAGDVITVLEQHPDGR-WKGHIHESQRGTDRIGYFPPGIVEVV----SKRVGI 351
DP L AG + HPDG +G H++ + G PG + SKRVG
Sbjct: 515 DPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGY 568
Query: 352 PAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 411
+ P + P LT++ P G + + GDR+ S
Sbjct: 569 ---------------LTGLPTTNSRSHPETLTHTASPHPGGAEE---GDRSGARSRAPPT 610
Query: 412 SIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLH--------PPSLADNLSH 463
S A S + L + + L PS A
Sbjct: 611 SKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDE 670
Query: 464 RPLANCRSGEQI-FTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTI-- 520
GE I F+Q+ + L + Q++ WL L+ Y + L G+D
Sbjct: 671 IEKIMSSIGEGIDFSQERQKISGLRTLE-QSVGEWLESIGLQQYESKLLLNGFDDVHFLG 729
Query: 521 -SRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL--PSYIPTDLLEWLCALGLPQYHK 577
+ M +DL IG++ P HR+K+ L + L P + WL +LGL Y
Sbjct: 730 SNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVH 789
Query: 578 QLVSSGYDSMGLVADLTWEELQEI-GVNKLGHQKKLM 613
+SSGY S+ V +L EL + V LGH+K+++
Sbjct: 790 SFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRII 826
Score = 41.6 bits (96), Expect = 0.005
Identities = 19/61 (31%), Positives = 38/61 (62%), Gaps = 2/61 (3%)
Query: 565 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 622
EWL ++GL QY +L+ +G+D + + EE L++IG++ H++KL+ + L ++
Sbjct: 703 EWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKV 762
Query: 623 R 623
+
Sbjct: 763 K 763
Score = 34.3 bits (77), Expect = 0.73
Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Query: 487 EGKDAQAIHNWLSEFQLEGYTAHFLQAGY-DVPTISRMTPEDL-TAIGVTKPGHRKKIAS 544
+G ++ +WL L+ Y FL +GY + T+ + +L + V GHRK+I +
Sbjct: 768 DGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIA 827
Query: 545 EIA 547
+A
Sbjct: 828 SLA 830
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 133 bits (334), Expect = 1e-30
Identities = 96/300 (32%), Positives = 153/300 (51%), Gaps = 29/300 (9%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L A +NGD + + L+ K +VN D +G + +H A G ++
Sbjct: 508 LHFAAQNGDESSTRLLLEK-------------NASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRA-SAAVNAASLDGQIPLHLAAQY 125
+LL V ++ + PLHYAAWQG L V+LL + +VNA +LDG+ PLHLAAQ
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
Query: 126 GHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC 185
GHY V+ +L+ S+ + + +TPL +A E G A+LLL+ G K+
Sbjct: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH--------RGAGKEAM 666
Query: 186 DPNYTTPLHLAAKNGHREVIRQLLRAGIEI-NRQTKTGTALHEAALYGKTEVVRLLLEGG 244
+ T LHLAA+NGH ++ L+ ++ R TALH AA +G +EVV L
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL---- 722
Query: 245 VDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVR 304
V ++ + +++ L ++ + ++ ++ LLR + I +++LK F H P A +R
Sbjct: 723 VSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI-NLQSLK-FQGGHGPAATLLR 780
Score = 120 bits (301), Expect = 8e-27
Identities = 86/241 (35%), Positives = 122/241 (50%), Gaps = 16/241 (6%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
++++VN +D D ++ALH AA G LLLE A+V+ D G P+H A G+
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENI 552
Query: 98 VRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK----KTPLD 153
VR+LLR V+ D +PLH AA GH + ++L + P + A+ +TPL
Sbjct: 553 VRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK---QPGVSVNAQTLDGRTPLH 609
Query: 154 LACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI 213
LA + G +VA++L++ LC + + C TPLH+AA+ GH R LL G
Sbjct: 610 LAAQRGHYRVARILID--LCSDV------NVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 214 EINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASRE 272
T G TALH AA G V+LL+E DV R NQTAL + S+ E
Sbjct: 662 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 273 I 273
+
Sbjct: 722 L 722
Score = 98.6 bits (244), Expect = 3e-20
Identities = 91/311 (29%), Positives = 144/311 (46%), Gaps = 16/311 (5%)
Query: 20 QKLV-AKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIK 78
+KLV A V +KL+ + +V+ G S LH A G E LL A ++
Sbjct: 408 KKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLS 467
Query: 79 DSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 138
+ G PLH A + V LLL +VNA D LH AAQ G + +LL+
Sbjct: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 139 SNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAK 198
++ V+ +TP+ +AC+ G+ + ++LL + V+L + KD PLH AA
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL---QGKDA-----WLPLHYAAW 579
Query: 199 NGHREVIRQLLR-AGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQT 256
GH +++ L + G+ +N QT G T LH AA G V R+L++ DVN+ + QT
Sbjct: 580 QGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQT 639
Query: 257 ALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHP 316
L + + + +R LL +G K D + A N V ++E+
Sbjct: 640 PLHVAAETGHTSTAR---LLLHRGAG--KEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694
Query: 317 DGRWKGHIHES 327
D +G ++++
Sbjct: 695 DVLARGPLNQT 705
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 125 bits (315), Expect = 2e-28
Identities = 151/544 (27%), Positives = 198/544 (36%), Gaps = 104/544 (19%)
Query: 665 LTFQGSELSP--------------ELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGH 710
L+FQGS+ SP +A+ P+ + LPP +P+ + G
Sbjct: 841 LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP 900
Query: 711 SQEQP--APQPSGGDPSPPQERNL-----------PEGTERPPKLCSSLPGQGP----PP 753
+ P AP S SP + R P+G PP P GP P
Sbjct: 901 ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK 960
Query: 754 YVFMYPQGSPSSPAPGP----PPGAPWAFSYLAGPPATPPDP------PRPKRRSHSLSR 803
+ P +P SP GP P GAP P ATPP P P PK +
Sbjct: 961 WAPTPPAATPPSPKGGPATPSPKGAP------TPPAATPPSPKGGPATPSPKGAPTPPAV 1014
Query: 804 PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 863
P+ + P G++ AT G A TPA P +
Sbjct: 1015 TPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP 1074
Query: 864 RRKGPPPPPPKRLSSVSG----PSPE---PPPLDESPGPKEG-ATGPRRRTLSEPAG-PS 914
KG P PP S G PSP+ PP P PK G AT P + + PA P
Sbjct: 1075 SLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP 1134
Query: 915 EPPG---PPAPAGPASDTEEEEPGPEG---TPPSRG--SSGEGLPFAEEGNLTIKQRPKP 966
P G P P G + P P+G TPP +G ++ P + +G L P P
Sbjct: 1135 SPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA---TPSP 1191
Query: 967 AGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT 1026
G P PP L PK P A+ P P L +P+
Sbjct: 1192 KGAPTTPAATPPSPKGGLATPS-----PKGAPTTP----------AATPPSPKGGLATPS 1236
Query: 1027 PGESP--PASSLPQPE--PSSLPAQGVPTPLAPSP------AMQPPVPPCPGPGLESSAA 1076
P +P PA++ P P+ P++ P +G PTP A +P PP P P + + +
Sbjct: 1237 PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296
Query: 1077 SRWNGETEPP-AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPES 1135
+ T PP AP P A T P P T PK AP P V PP P+
Sbjct: 1297 PKGGPATSPPKGAP-----TPPAATPPSPKGSPGT----PPPKGAPT--PPAVTPPSPKG 1345
Query: 1136 TGTV 1139
T T+
Sbjct: 1346 TPTL 1349
Score = 121 bits (303), Expect = 5e-27
Identities = 155/584 (26%), Positives = 206/584 (35%), Gaps = 77/584 (13%)
Query: 655 EGPATAGPR---LLTFQGSE-----LSPELQAAMAGGGPEPLPLPPARSPSQESIGARSR 706
EGPAT P+ L+ S +P + A P+ P PPA +P G +
Sbjct: 898 EGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATP 957
Query: 707 GSGHSQEQPA---PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSP 763
+ PA P P GG +P P+G PP P GP P+G+P
Sbjct: 958 SPKWAPTPPAATPPSPKGGPATPS-----PKGAPTPPAATPPSPKGGPAT---PSPKGAP 1009
Query: 764 SSPA--PGPPPGAPWAFSYLAG---PPATPPDPPRPKRRSHSLSRPGPTEGDAE--GEAE 816
+ PA P P G+P A + G PPA P P+ + L + PT A
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069
Query: 817 GPVGSTLGSYAT---LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRAR-RKGPPPPP 872
GP +L T T + SP P P TP S L KG P P
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTP 1129
Query: 873 PKRLSSVSGPSPEPPPLDES-------PGPKEG-ATGPRRRTLSEPAG-PSEPPG---PP 920
S G PPP P PK G AT P + + PA P P G P
Sbjct: 1130 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1189
Query: 921 APAGPASDTEEEEPGPEG---TPPSRGS--SGEGLPFAEEGNLTIKQ------------- 962
+P G + P P+G TP +G+ + P + +G L
Sbjct: 1190 SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1249
Query: 963 RPK--PAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA 1020
PK PA PPP+ P PP + K + T G + +P A
Sbjct: 1250 SPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGA 1309
Query: 1021 PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWN 1080
P P P +PP+ P+ P + P +G PTP A +P P P S
Sbjct: 1310 PTP---PAATPPS---PKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTP 1363
Query: 1081 GETEPPAAPAALLKVPG--AGTAPKP---VSVACTQLAFSGPKLAPRLGPR--PVPPPRP 1133
E P PAA G A T P P ++ + + P + P L P+ P P
Sbjct: 1364 SSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP-LSPKKAPATPVTR 1422
Query: 1134 ESTGTVGPGQ-AQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1176
E T G + S A A A + T +G P+
Sbjct: 1423 EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPT 1466
Score = 98.6 bits (244), Expect = 3e-20
Identities = 140/521 (26%), Positives = 188/521 (36%), Gaps = 94/521 (18%)
Query: 687 PLPLPPARSPSQESIGARSRGSGH---SQEQPAPQPSGGDPSPPQERNLPEGTERPPKLC 743
P+ P P+++S GA + S + +P P G SP T+RPP
Sbjct: 762 PVASSPKECPTEDS-GASATASSKGTLTYLADSPSPLGVSVSPQ--------TKRPPTKK 812
Query: 744 SSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSR 803
S GP P G+ SSP +P S+L +SLS
Sbjct: 813 GSA---GPDT-----PIGNLSSPV------SPVEASFLP---------------ENSLSF 843
Query: 804 PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 863
G + A + P S G+ P SA+ SP P + TP L
Sbjct: 844 QGSKDSPATTHSPTPP-SPKGA-------PTPSAVTPLSPKGVTLPPKETPTPSVVNLPF 895
Query: 864 RRKGPPPPPPKRLSSVSGPS---------PEPPPLDESPGPKEGATGPRRRTLSEPAGPS 914
++GP P PK+ ++S S P P + SP PK T P S GP+
Sbjct: 896 PKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPA 955
Query: 915 EPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPK--PAGPPPR 972
P AP PA+ P P+G P + G P A PK PA P P+
Sbjct: 956 TPSPKWAPTPPAA----TPPSPKGGPATPSPKGAPTPPA-----ATPPSPKGGPATPSPK 1006
Query: 973 ETPVPPGLDFNLTE-SDTVKRRPKCREREPLQTALLAFGVASATP-------GPAAPLPS 1024
P PP + + S PK P T G +ATP PAA LPS
Sbjct: 1007 GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066
Query: 1025 PTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP--AMQPP--VPPCPGPGLESSAASRWN 1080
P G + P+ P++ P P PSP A PP PP P GL +
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP----- 1121
Query: 1081 GETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1140
P PAA P G A P A T A + P +P+ G PP +T
Sbjct: 1122 -HKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP--SPKGGLATPPPKGAPTTPAAT 1178
Query: 1141 P-----GQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1176
P G A + ++ AA + + + T +G P+
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1219
Score = 94.4 bits (233), Expect = 6e-19
Identities = 139/606 (22%), Positives = 209/606 (34%), Gaps = 130/606 (21%)
Query: 668 QGSELSPELQAAMAGGGPEPL----PLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGD 723
+G+ P + GG P P PPA +PS + G + P+P+
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG--------GPAMTPPSPKRGPAI 1395
Query: 724 PSPPQERNLPEGTERPPKLCSSLP-----------GQGPPPYVFMYPQGSPSSPAPGPPP 772
PSP + P PK + P G PP V P +PA P
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVT--PVSLKKAPATSAPK 1453
Query: 773 GAPWAFSYLAGP------PATPPDPPRPKRRSHSLS------------------------ 802
G P S P P +P +PP PK+ + S S
Sbjct: 1454 GGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP 1513
Query: 803 RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSAL--VRTSPSVTPTPARGTPRSQSFA 860
+ P + + P + L T P + + T PS TPA TP+ ++ A
Sbjct: 1514 KEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK-EAPA 1572
Query: 861 LRARRKGPPPPPPKRLSSVSGPSPEP---PPLDESPGPKEGATGPRRRTLSEPAGPSEPP 917
+ ++ PP + PSP+ PP SP PKE T P S GP+ P
Sbjct: 1573 TPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPA 1632
Query: 918 GPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKP-----AGPPPR 972
P P + P G +P A +G L K+ P P P
Sbjct: 1633 PKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKG-LPAKKGPTALKEVLVAPAPE 1691
Query: 973 ETPV--PPGLDFNLTESDTVKRRPKCRE-------REPLQTA----LLAFGVAS------ 1013
TP+ P T+ + P C + + PL T LL S
Sbjct: 1692 STPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKG 1751
Query: 1014 --ATPGPAAPLPSPTPGESPPASS------LPQPEPSSLPAQGVPTPLAPSPAMQPPVPP 1065
A+ P PL P S P ++ LP+PE +S+ A APSP + P+ P
Sbjct: 1752 KDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSA-------APSPPVSLPLAP 1804
Query: 1066 CPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGP 1125
P P L + P++P +L+ P AP +L P + P
Sbjct: 1805 SPVPTLPPK-------QQFLPSSPGLVLESPSKPLAPA-----------DEDELLPLIPP 1846
Query: 1126 RP-----------VPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGT 1174
P V P P+S G P + ++ ++ + +++S+ E++ +
Sbjct: 1847 EPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDS 1906
Query: 1175 PSASTK 1180
A+T+
Sbjct: 1907 TQATTQ 1912
Score = 46.6 bits (109), Expect = 1e-04
Identities = 110/457 (24%), Positives = 160/457 (35%), Gaps = 84/457 (18%)
Query: 785 PATPP--DPPRPKRRSHSLSRPGPTEGDAE---GEAEGPVGSTLGSYATLTRRPGRSALV 839
P +PP DP K S+ PT+ D + EG S + T + P LV
Sbjct: 504 PVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLV 563
Query: 840 RTSPSVTPT-----PARGTPRSQSFALRARRKGPPPPPPKRLSSVSGP-----SPEPPPL 889
+ +P +P+ + P S L + G P P K SS++ P S
Sbjct: 564 QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623
Query: 890 DESPGPKEGATGPR-RRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 948
D GP + GP + +L P + P PAG A T + GT ++
Sbjct: 624 DSYAGPD--SAGPLLKSSLITPTVAAFPLESADPAGVAPTTAK------GTSTYTTTAS- 674
Query: 949 GLPFAEEGNLTIKQRPKPAGPPPRET-PVPPGLDFNLTESDTVKRRPKCRER-EPLQTAL 1006
PF E G +++ + P T P+ P T S+ P + PL T +
Sbjct: 675 --PFLE-GTVSLAPKNHPVKEGTLTTLPLVP------TASENCPVAPSPQNTCAPLATLV 725
Query: 1007 LAFGVASATPGPAAPLPSPTPGES-----------PPASSLPQPEP-------SSLPAQG 1048
LA + + P P+ P PG P +S P+ P ++ ++G
Sbjct: 726 LAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKG 785
Query: 1049 V-------PTPLAPSPAMQPPVPP----CPGPGLESSAASRWNGETEPPAAPAALLKVPG 1097
P+PL S + Q PP GP S E P L G
Sbjct: 786 TLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQG 845
Query: 1098 AGTAP-------------KPVSVACTQLAFSGPKLAPRLGPRP----VPPPRPESTGTVG 1140
+ +P P A T L+ G L P+ P P +P P+ E T
Sbjct: 846 SKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPK-EGPATPA 904
Query: 1141 PGQAQQRLEQTSSSLAAALRAAEKSI-GTKEQEGTPS 1176
P QA +SS A A K I + +G P+
Sbjct: 905 PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPT 941
Score = 40.4 bits (93), Expect = 0.010
Identities = 105/446 (23%), Positives = 142/446 (31%), Gaps = 120/446 (26%)
Query: 713 EQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPA----P 768
EQ PQP + LP + PG PP PQ P S A P
Sbjct: 13 EQELPQPQA------ETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASP 66
Query: 769 GPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYAT 828
P P S +A P P P + S + P T +A +G +
Sbjct: 67 FPSP------STIASTPLEVPFP----QSSSGTALPLGTAPEAPTFLPNLIGPPISP--- 113
Query: 829 LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPP 888
+AL SP + PT +GTP S S L P SV S PP
Sbjct: 114 -------AALALASPMIAPT-LKGTP-SSSAPLALVALAP--------HSVQKSSAFPPN 156
Query: 889 LDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 948
L SP A TLS P PSEP
Sbjct: 157 LLTSPPSVAVAESGSVITLSAPIAPSEP-------------------------------- 184
Query: 949 GLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLA 1008
+ + P P P+ TP PP + + A +
Sbjct: 185 --------KTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVT------------PMASIQ 224
Query: 1009 FGVAS---ATPGPAAPLPSPTPGESPPASSLPQPE-PSSLPAQGVPTPLAPSPAMQPPVP 1064
GVAS TP + SP ++ +S L P+ P SL +G P++P A+
Sbjct: 225 SGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKG---PVSPPAALSLSTQ 281
Query: 1065 PCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLG 1124
P +++ + G PP P +L G+ AP Q +F +L + G
Sbjct: 282 SLP----VVTSSQKTAGPNTPPDFPISL----GSHLAP------LHQSSFGSVQLLGQTG 327
Query: 1125 PRPVPPPRPE-------STGTVGPGQ 1143
P + P + STG P Q
Sbjct: 328 PSALSDPTVKTISVDHSSTGASYPSQ 353
Score = 38.5 bits (88), Expect = 0.039
Identities = 126/553 (22%), Positives = 181/553 (32%), Gaps = 97/553 (17%)
Query: 633 SEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPL---- 688
S G L G A L N GP + P L ++P L+ + P L
Sbjct: 85 SSSGTALPLGTAPEAPTFLPNLIGPPIS-PAALALASPMIAPTLKGTPSSSAPLALVALA 143
Query: 689 --------PLPPARSPSQESIGARSRGSGHSQEQP-APQP--SGGDPSPPQERNLPEGTE 737
PP S S+ GS + P AP + + P + P+GT
Sbjct: 144 PHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTP 203
Query: 738 RPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRR 797
PP + S++ PY + P S S P P +A P
Sbjct: 204 SPPCIVSTV------PYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKD-----TTIS 252
Query: 798 SHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTP--ARGTPR 855
S +S P +G P +L + + + +P P + P
Sbjct: 253 SVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPL 312
Query: 856 SQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSE 915
QS + G P S++S P+ + +D S GA+ P +R++
Sbjct: 313 HQSSFGSVQLLGQTGP-----SALSDPTVKTISVDHS---STGASYPSQRSVI------- 357
Query: 916 PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETP 975
PP P+ E P + + P ++G TI P
Sbjct: 358 ---PPLPS-----------RNEVVPATVAAFPVVAPSVDKGPSTIS---SITCSPSGSLN 400
Query: 976 VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVAS-----ATPGPAAPLPSPT---- 1026
V + T S +K P PL + V + P A P+ T
Sbjct: 401 VATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVA 460
Query: 1027 PGESPPASSLP--QPEPSSLPAQGVPTPLAP-SPAMQ-------PPVPPCPGP----GLE 1072
SPP SS P EP+S PA V P+AP P+ Q P PP P P L
Sbjct: 461 TCVSPPMSSGPISNIEPTS-PAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLP 519
Query: 1073 SSAASRWNGETEPPAAPAALLKVP------GAGTAPKPVSVACTQLAFSGPKLAPRL--- 1123
SS ++ + + PA+L P G T P + Q A PK +P
Sbjct: 520 SSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAA---PKNSPSFQST 576
Query: 1124 GPRPVPPPRPEST 1136
P P PE+T
Sbjct: 577 SSSPEIPLSPEAT 589
Score = 36.2 bits (82), Expect = 0.19
Identities = 41/134 (30%), Positives = 51/134 (38%), Gaps = 12/134 (8%)
Query: 994 PKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPL 1053
P + P A A S+ A L P P PP S PQ P S Q P P
Sbjct: 10 PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPS 69
Query: 1054 APSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLA 1113
+ A P P P +SS+ + T P AP L + G P+S A LA
Sbjct: 70 PSTIASTPLEVPFP----QSSSGTALPLGT-APEAPTFLPNLIG-----PPISPAA--LA 117
Query: 1114 FSGPKLAPRLGPRP 1127
+ P +AP L P
Sbjct: 118 LASPMIAPTLKGTP 131
Score = 34.3 bits (77), Expect = 0.73
Identities = 77/341 (22%), Positives = 114/341 (33%), Gaps = 51/341 (14%)
Query: 813 GEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPP 872
GEA V +T L + +A++ S +++ T A G P GP PP
Sbjct: 3 GEATETVPAT---EQELPQPQAETAVLPMSSALSVTAALGQP------------GPTLPP 47
Query: 873 PKRLSSVSGPSPEPPPLDES------PGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPA 926
P P+P+ PL + P P A+ P E P G P G A
Sbjct: 48 P------CSPAPQQCPLSAANQASPFPSPSTIASTPL-----EVPFPQSSSGTALPLGTA 96
Query: 927 SDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLT- 985
+ P G P S + P T+K P + P P + +
Sbjct: 97 PEAPTFLPNLIGPPISPAALALASPMIAP---TLKGTPSSSAPLALVALAPHSVQKSSAF 153
Query: 986 ESDTVKRRPKCREREPLQTALLAFGVASATPG------PAAPLPSPTPGESPPASSLPQP 1039
+ + P E L+ +A + P P+ +P+P SPP P
Sbjct: 154 PPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVP 213
Query: 1040 EPSSLPAQGVPTPLAPSPAMQPPVP-PCPGPGLESSAASRWNGETEPPAAPAAL-LKVPG 1097
P + + +A P P P ++ + S P P +L LK P
Sbjct: 214 YHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTIS---SVLISPQNPGSLSLKGPV 270
Query: 1098 AGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGT 1138
+ A +S + S K A GP PP P S G+
Sbjct: 271 SPPAALSLSTQSLPVVTSSQKTA---GPN-TPPDFPISLGS 307
Score = 32.0 bits (71), Expect = 3.6
Identities = 34/115 (29%), Positives = 41/115 (35%), Gaps = 8/115 (6%)
Query: 352 PAARLPSAPT-PLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSV 410
PAA LPS P P P PPA PP P P +P PA S +G +
Sbjct: 1060 PAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS--PKGGL 1117
Query: 411 GSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRP 465
+ G+ + T G L A P P P PPS L+ P
Sbjct: 1118 ATPPHKGAPTTPAATPPSPKGGL---ATPPPKGA--PTTPAATPPSPKGGLATPP 1167
Score = 31.2 bits (69), Expect = 6.2
Identities = 32/126 (25%), Positives = 42/126 (33%), Gaps = 20/126 (15%)
Query: 351 IPAARLPSAPTPLRPGFSRTPQPPAEEPPH---PLTYSQLPRVGLSPDSPAGDRNSVG-- 405
+PA S P P P PPA P H P P+ G + SP GD S
Sbjct: 1349 LPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVI 1408
Query: 406 ----SEGSVGSIRSAGSGQSSEG----------TNGHGPGLLIENAQP-LPSAGEDQVLP 450
+ + G+ S+G + P P PS+ D LP
Sbjct: 1409 PLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLP 1468
Query: 451 GLHPPS 456
+ PPS
Sbjct: 1469 AVTPPS 1474
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 123 bits (308), Expect = 1e-27
Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +G + LH A +L+++ LLL + NG PLH AA Q ++E R LL
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ + NA S+ G PLHLAAQ GH E+ +LL Q+N L NK+ TPL L + G +
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
VA +L+ G D TPLH+A+ G+ ++++ LL+ ++N +TK G
Sbjct: 716 VADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL+ G N ++ T L I + + +K + E S
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 827
Query: 282 GIL 284
+L
Sbjct: 828 FVL 830
Score = 115 bits (289), Expect = 2e-25
Identities = 77/221 (34%), Positives = 114/221 (51%), Gaps = 13/221 (5%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + +GF+ LH A + ++ LLL+ A++D +G+ PLH A++ G L V+ LL
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ N +++ + PLH+AA+ GH EV++ LLQ+++ K +TPL A G
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 163 VAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LLL N++ +A G TPLH+AA+ GH E + LL TK
Sbjct: 518 MVKLLLENNANPNLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTK 567
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH AA YGK V LLLE N T L +
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
Score = 115 bits (289), Expect = 2e-25
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 9/254 (3%)
Query: 11 VKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLE 70
V N V + A+ T+ + VN + D + LH AA G ++ LLLE
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 71 AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEV 130
A ++ + G PLH AA +G +E V LL A+ + G PLH+AA+YG V
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 131 SEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+E+LL+ ++P K TPL +A L + +LLL G P Y
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR-------GGSPHSPAWNGY- 636
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
TPLH+AAK EV R LL+ G N ++ G T LH AA G E+V LLL + N+
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 250 RNTYNQTALDIVNQ 263
N T L +V Q
Sbjct: 697 GNKSGLTPLHLVAQ 710
Score = 107 bits (268), Expect = 5e-23
Identities = 83/280 (29%), Positives = 129/280 (46%), Gaps = 26/280 (9%)
Query: 22 LVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSN 81
+ A+ T+T + N + GF+ LH AA +L + LLL A+V+ N
Sbjct: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271
Query: 82 GMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 141
G+ PLH A+ +G + VRLLL A + + D PLH AA+ GH +SE+LL H +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 142 CLVNKAKKTPLDLACEFGRLKVAQLLLN----------SHLC---------------VAL 176
K +P+ +A + L +LLL HL V L
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Query: 177 LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTE 235
+G + N TPLH+A K H V+ LL+ G I+ T++G T LH A+ G
Sbjct: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451
Query: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
+V+ LL+ G N+ N +T L + + ++ ++ + Q
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 22/241 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G + LH A+ G ++++ LL + ++ G LH AA G+ E VR
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
L+ A VNA S G PL++AAQ H EV + LL++ +N + + TPL +A + G
Sbjct: 129 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188
Query: 160 RLKVAQLLLN--------------------SHLCVALLEGEAK-DPCDPNYTTPLHLAAK 198
V L+N + LL+ + D TPLH+AA
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
+ V + LL G +N + G T LH A+ G +VRLLL+ G + + T
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 258 L 258
L
Sbjct: 309 L 309
Score = 90.5 bits (223), Expect = 9e-18
Identities = 67/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA 111
ALH AA A+LL+ D+ G PLH AA L +LLL A+VN
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
+G PLH+A++ G+ + +LL + K + TPL A G ++++++LL+
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
A ++ + K N +P+H+AA+ H + +R LL+ EI+ T T LH AA
Sbjct: 329 ---APIQAKTK-----NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G V ++LL+ G N R T L I
Sbjct: 381 CGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410
Score = 86.7 bits (213), Expect = 1e-16
Identities = 51/164 (31%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N + G + LH AA G E++ALLL QA ++ + +G+ PLH A +G + +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 719
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L++ V+A + G PLH+A+ YG+ ++ + LLQHQ++ K +PL A + G
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 779
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ LLL + G + + + TTPL +A + G+ V
Sbjct: 780 TDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYISV 815
Score = 74.3 bits (181), Expect = 6e-13
Identities = 44/131 (33%), Positives = 70/131 (53%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+K+ N N + G + LH A G + + +L++ VD G PLH A+ G ++
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V+ LL+ A VNA + G PLH AAQ GH ++ +LL++ ++P V+ TPL +A
Sbjct: 749 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Query: 157 EFGRLKVAQLL 167
G + V +L
Sbjct: 809 RLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 123 bits (308), Expect = 1e-27
Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +G + LH A +L+++ LLL + NG PLH AA Q ++E R LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ + NA S+ G PLHLAAQ GH E+ +LL Q+N L NK+ TPL L + G +
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
VA +L+ G D TPLH+A+ G+ ++++ LL+ ++N +TK G
Sbjct: 683 VADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL+ G N ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 GIL 284
+L
Sbjct: 795 FVL 797
Score = 115 bits (289), Expect = 2e-25
Identities = 77/221 (34%), Positives = 114/221 (51%), Gaps = 13/221 (5%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + +GF+ LH A + ++ LLL+ A++D +G+ PLH A++ G L V+ LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ N +++ + PLH+AA+ GH EV++ LLQ+++ K +TPL A G
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 163 VAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LLL N++ +A G TPLH+AA+ GH E + LL TK
Sbjct: 485 MVKLLLENNANPNLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH AA YGK V LLLE N T L +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 115 bits (289), Expect = 2e-25
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 9/254 (3%)
Query: 11 VKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLE 70
V N V + A+ T+ + VN + D + LH AA G ++ LLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 71 AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEV 130
A ++ + G PLH AA +G +E V LL A+ + G PLH+AA+YG V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 131 SEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+E+LL+ ++P K TPL +A L + +LLL G P Y
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR-------GGSPHSPAWNGY- 603
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
TPLH+AAK EV R LL+ G N ++ G T LH AA G E+V LLL + N+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 250 RNTYNQTALDIVNQ 263
N T L +V Q
Sbjct: 664 GNKSGLTPLHLVAQ 677
Score = 107 bits (268), Expect = 5e-23
Identities = 83/280 (29%), Positives = 129/280 (46%), Gaps = 26/280 (9%)
Query: 22 LVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSN 81
+ A+ T+T + N + GF+ LH AA +L + LLL A+V+ N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 82 GMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 141
G+ PLH A+ +G + VRLLL A + + D PLH AA+ GH +SE+LL H +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 142 CLVNKAKKTPLDLACEFGRLKVAQLLLN----------SHLC---------------VAL 176
K +P+ +A + L +LLL HL V L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 177 LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTE 235
+G + N TPLH+A K H V+ LL+ G I+ T++G T LH A+ G
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
+V+ LL+ G N+ N +T L + + ++ ++ + Q
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 22/241 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G + LH A+ G ++++ LL + ++ G LH AA G+ E VR
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
L+ A VNA S G PL++AAQ H EV + LL++ +N + + TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RLKVAQLLLN--------------------SHLCVALLEGEAK-DPCDPNYTTPLHLAAK 198
V L+N + LL+ + D TPLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
+ V + LL G +N + G T LH A+ G +VRLLL+ G + + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 90.5 bits (223), Expect = 9e-18
Identities = 67/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA 111
ALH AA A+LL+ D+ G PLH AA L +LLL A+VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
+G PLH+A++ G+ + +LL + K + TPL A G ++++++LL+
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
A ++ + K N +P+H+AA+ H + +R LL+ EI+ T T LH AA
Sbjct: 296 ---APIQAKTK-----NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G V ++LL+ G N R T L I
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 86.7 bits (213), Expect = 1e-16
Identities = 51/164 (31%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N + G + LH AA G E++ALLL QA ++ + +G+ PLH A +G + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L++ V+A + G PLH+A+ YG+ ++ + LLQHQ++ K +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ LLL + G + + + TTPL +A + G+ V
Sbjct: 747 TDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 74.3 bits (181), Expect = 6e-13
Identities = 44/131 (33%), Positives = 70/131 (53%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+K+ N N + G + LH A G + + +L++ VD G PLH A+ G ++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V+ LL+ A VNA + G PLH AAQ GH ++ +LL++ ++P V+ TPL +A
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 157 EFGRLKVAQLL 167
G + V +L
Sbjct: 776 RLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 123 bits (308), Expect = 1e-27
Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +G + LH A +L+++ LLL + NG PLH AA Q ++E R LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ + NA S+ G PLHLAAQ GH E+ +LL Q+N L NK+ TPL L + G +
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
VA +L+ G D TPLH+A+ G+ ++++ LL+ ++N +TK G
Sbjct: 683 VADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL+ G N ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 GIL 284
+L
Sbjct: 795 FVL 797
Score = 115 bits (289), Expect = 2e-25
Identities = 77/221 (34%), Positives = 114/221 (51%), Gaps = 13/221 (5%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + +GF+ LH A + ++ LLL+ A++D +G+ PLH A++ G L V+ LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ N +++ + PLH+AA+ GH EV++ LLQ+++ K +TPL A G
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 163 VAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LLL N++ +A G TPLH+AA+ GH E + LL TK
Sbjct: 485 MVKLLLENNANPNLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH AA YGK V LLLE N T L +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 115 bits (289), Expect = 2e-25
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 9/254 (3%)
Query: 11 VKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLE 70
V N V + A+ T+ + VN + D + LH AA G ++ LLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 71 AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEV 130
A ++ + G PLH AA +G +E V LL A+ + G PLH+AA+YG V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 131 SEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+E+LL+ ++P K TPL +A L + +LLL G P Y
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR-------GGSPHSPAWNGY- 603
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
TPLH+AAK EV R LL+ G N ++ G T LH AA G E+V LLL + N+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 250 RNTYNQTALDIVNQ 263
N T L +V Q
Sbjct: 664 GNKSGLTPLHLVAQ 677
Score = 107 bits (268), Expect = 5e-23
Identities = 83/280 (29%), Positives = 129/280 (46%), Gaps = 26/280 (9%)
Query: 22 LVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSN 81
+ A+ T+T + N + GF+ LH AA +L + LLL A+V+ N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 82 GMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 141
G+ PLH A+ +G + VRLLL A + + D PLH AA+ GH +SE+LL H +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 142 CLVNKAKKTPLDLACEFGRLKVAQLLLN----------SHLC---------------VAL 176
K +P+ +A + L +LLL HL V L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 177 LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTE 235
+G + N TPLH+A K H V+ LL+ G I+ T++G T LH A+ G
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
+V+ LL+ G N+ N +T L + + ++ ++ + Q
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 22/241 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G + LH A+ G ++++ LL + ++ G LH AA G+ E VR
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
L+ A VNA S G PL++AAQ H EV + LL++ +N + + TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RLKVAQLLLN--------------------SHLCVALLEGEAK-DPCDPNYTTPLHLAAK 198
V L+N + LL+ + D TPLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
+ V + LL G +N + G T LH A+ G +VRLLL+ G + + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 90.5 bits (223), Expect = 9e-18
Identities = 67/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA 111
ALH AA A+LL+ D+ G PLH AA L +LLL A+VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
+G PLH+A++ G+ + +LL + K + TPL A G ++++++LL+
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
A ++ + K N +P+H+AA+ H + +R LL+ EI+ T T LH AA
Sbjct: 296 ---APIQAKTK-----NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G V ++LL+ G N R T L I
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 86.7 bits (213), Expect = 1e-16
Identities = 51/164 (31%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N + G + LH AA G E++ALLL QA ++ + +G+ PLH A +G + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L++ V+A + G PLH+A+ YG+ ++ + LLQHQ++ K +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ LLL + G + + + TTPL +A + G+ V
Sbjct: 747 TDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 74.3 bits (181), Expect = 6e-13
Identities = 44/131 (33%), Positives = 70/131 (53%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+K+ N N + G + LH A G + + +L++ VD G PLH A+ G ++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V+ LL+ A VNA + G PLH AAQ GH ++ +LL++ ++P V+ TPL +A
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 157 EFGRLKVAQLL 167
G + V +L
Sbjct: 776 RLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 123 bits (308), Expect = 1e-27
Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +G + LH A +L+++ LLL + NG PLH AA Q ++E R LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ + NA S+ G PLHLAAQ GH E+ +LL Q+N L NK+ TPL L + G +
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
VA +L+ G D TPLH+A+ G+ ++++ LL+ ++N +TK G
Sbjct: 683 VADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL+ G N ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 GIL 284
+L
Sbjct: 795 FVL 797
Score = 115 bits (289), Expect = 2e-25
Identities = 77/221 (34%), Positives = 114/221 (51%), Gaps = 13/221 (5%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + +GF+ LH A + ++ LLL+ A++D +G+ PLH A++ G L V+ LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ N +++ + PLH+AA+ GH EV++ LLQ+++ K +TPL A G
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 163 VAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LLL N++ +A G TPLH+AA+ GH E + LL TK
Sbjct: 485 MVKLLLENNANPNLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH AA YGK V LLLE N T L +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 115 bits (289), Expect = 2e-25
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 9/254 (3%)
Query: 11 VKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLE 70
V N V + A+ T+ + VN + D + LH AA G ++ LLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 71 AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEV 130
A ++ + G PLH AA +G +E V LL A+ + G PLH+AA+YG V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 131 SEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+E+LL+ ++P K TPL +A L + +LLL G P Y
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR-------GGSPHSPAWNGY- 603
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
TPLH+AAK EV R LL+ G N ++ G T LH AA G E+V LLL + N+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 250 RNTYNQTALDIVNQ 263
N T L +V Q
Sbjct: 664 GNKSGLTPLHLVAQ 677
Score = 107 bits (268), Expect = 5e-23
Identities = 83/280 (29%), Positives = 129/280 (46%), Gaps = 26/280 (9%)
Query: 22 LVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSN 81
+ A+ T+T + N + GF+ LH AA +L + LLL A+V+ N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 82 GMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 141
G+ PLH A+ +G + VRLLL A + + D PLH AA+ GH +SE+LL H +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 142 CLVNKAKKTPLDLACEFGRLKVAQLLLN----------SHLC---------------VAL 176
K +P+ +A + L +LLL HL V L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 177 LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTE 235
+G + N TPLH+A K H V+ LL+ G I+ T++G T LH A+ G
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
+V+ LL+ G N+ N +T L + + ++ ++ + Q
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 22/241 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G + LH A+ G ++++ LL + ++ G LH AA G+ E VR
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
L+ A VNA S G PL++AAQ H EV + LL++ +N + + TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RLKVAQLLLN--------------------SHLCVALLEGEAK-DPCDPNYTTPLHLAAK 198
V L+N + LL+ + D TPLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
+ V + LL G +N + G T LH A+ G +VRLLL+ G + + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 90.5 bits (223), Expect = 9e-18
Identities = 67/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA 111
ALH AA A+LL+ D+ G PLH AA L +LLL A+VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
+G PLH+A++ G+ + +LL + K + TPL A G ++++++LL+
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
A ++ + K N +P+H+AA+ H + +R LL+ EI+ T T LH AA
Sbjct: 296 ---APIQAKTK-----NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G V ++LL+ G N R T L I
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 86.7 bits (213), Expect = 1e-16
Identities = 51/164 (31%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N + G + LH AA G E++ALLL QA ++ + +G+ PLH A +G + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L++ V+A + G PLH+A+ YG+ ++ + LLQHQ++ K +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ LLL + G + + + TTPL +A + G+ V
Sbjct: 747 TDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 74.3 bits (181), Expect = 6e-13
Identities = 44/131 (33%), Positives = 70/131 (53%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+K+ N N + G + LH A G + + +L++ VD G PLH A+ G ++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V+ LL+ A VNA + G PLH AAQ GH ++ +LL++ ++P V+ TPL +A
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 157 EFGRLKVAQLL 167
G + V +L
Sbjct: 776 RLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 123 bits (308), Expect = 1e-27
Identities = 83/243 (34%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +G + LH A +L+++ LLL + NG PLH AA Q ++E R LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ + NA S+ G PLHLAAQ GH E+ +LL Q+N L NK+ TPL L + G +
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
VA +L+ G D TPLH+A+ G+ ++++ LL+ ++N +TK G
Sbjct: 683 VADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL+ G N ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 GIL 284
+L
Sbjct: 795 FVL 797
Score = 115 bits (289), Expect = 2e-25
Identities = 77/221 (34%), Positives = 114/221 (51%), Gaps = 13/221 (5%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + +GF+ LH A + ++ LLL+ A++D +G+ PLH A++ G L V+ LL
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ N +++ + PLH+AA+ GH EV++ LLQ+++ K +TPL A G
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 163 VAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LLL N++ +A G TPLH+AA+ GH E + LL TK
Sbjct: 485 MVKLLLENNANPNLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH AA YGK V LLLE N T L +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 115 bits (289), Expect = 2e-25
Identities = 87/254 (34%), Positives = 120/254 (47%), Gaps = 9/254 (3%)
Query: 11 VKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLE 70
V N V + A+ T+ + VN + D + LH AA G ++ LLLE
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 71 AQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEV 130
A ++ + G PLH AA +G +E V LL A+ + G PLH+AA+YG V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 131 SEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+E+LL+ ++P K TPL +A L + +LLL G P Y
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR-------GGSPHSPAWNGY- 603
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
TPLH+AAK EV R LL+ G N ++ G T LH AA G E+V LLL + N+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 250 RNTYNQTALDIVNQ 263
N T L +V Q
Sbjct: 664 GNKSGLTPLHLVAQ 677
Score = 107 bits (268), Expect = 5e-23
Identities = 83/280 (29%), Positives = 129/280 (46%), Gaps = 26/280 (9%)
Query: 22 LVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSN 81
+ A+ T+T + N + GF+ LH AA +L + LLL A+V+ N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 82 GMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 141
G+ PLH A+ +G + VRLLL A + + D PLH AA+ GH +SE+LL H +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 142 CLVNKAKKTPLDLACEFGRLKVAQLLLN----------SHLC---------------VAL 176
K +P+ +A + L +LLL HL V L
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 177 LEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTE 235
+G + N TPLH+A K H V+ LL+ G I+ T++G T LH A+ G
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
Query: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQ 275
+V+ LL+ G N+ N +T L + + ++ ++ + Q
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 22/241 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G + LH A+ G ++++ LL + ++ G LH AA G+ E VR
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
L+ A VNA S G PL++AAQ H EV + LL++ +N + + TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RLKVAQLLLN--------------------SHLCVALLEGEAK-DPCDPNYTTPLHLAAK 198
V L+N + LL+ + D TPLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
+ V + LL G +N + G T LH A+ G +VRLLL+ G + + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 90.5 bits (223), Expect = 9e-18
Identities = 67/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA 111
ALH AA A+LL+ D+ G PLH AA L +LLL A+VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
+G PLH+A++ G+ + +LL + K + TPL A G ++++++LL+
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
A ++ + K N +P+H+AA+ H + +R LL+ EI+ T T LH AA
Sbjct: 296 ---APIQAKTK-----NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G V ++LL+ G N R T L I
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 86.7 bits (213), Expect = 1e-16
Identities = 51/164 (31%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N + G + LH AA G E++ALLL QA ++ + +G+ PLH A +G + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L++ V+A + G PLH+A+ YG+ ++ + LLQHQ++ K +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ LLL + G + + + TTPL +A + G+ V
Sbjct: 747 TDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 74.3 bits (181), Expect = 6e-13
Identities = 44/131 (33%), Positives = 70/131 (53%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+K+ N N + G + LH A G + + +L++ VD G PLH A+ G ++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V+ LL+ A VNA + G PLH AAQ GH ++ +LL++ ++P V+ TPL +A
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 157 EFGRLKVAQLL 167
G + V +L
Sbjct: 776 RLGYISVTDVL 786
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 121 bits (304), Expect = 3e-27
Identities = 84/247 (34%), Positives = 125/247 (50%), Gaps = 26/247 (10%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N + G +ALH AA G E++ L++ A V+ K + PLH +A G+ + V+ LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
+ A+ NAA+ G PLHL+A+ GH +V+ LL H ++ + K TPL +A ++G+L+
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
Query: 163 VAQLLLNS---------------HLC-------VALL---EGEAKDPCDPNYTTPLHLAA 197
VA LLL H+ VALL +G + N TPLH+AA
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Query: 198 KNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLLEGGVDVNIRNTYNQT 256
K ++ LL G + N T+ G A +H AA G ++V LLL +VN+ N T
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699
Query: 257 ALDIVNQ 263
L + Q
Sbjct: 700 PLHLAAQ 706
Score = 113 bits (283), Expect = 9e-25
Identities = 101/344 (29%), Positives = 149/344 (43%), Gaps = 37/344 (10%)
Query: 2 GREQDLILAVKNGDVTGVQKL-----VAKVKATKTKLLGSTKRLNVNYQDADGFSALHHA 56
G +Q + L ++N D G +L A+ TK L N + + GF+ LH A
Sbjct: 184 GHDQVVSLLLEN-DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Query: 57 ALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQ 116
A G++ + LLL A VD N + PLH A+ +G V+LLL A ++A + DG
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 117 IPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCV-- 174
PLH A+ GH +V EMLL + K +PL +A + L QLLL ++ V
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
Query: 175 ----------------------ALLEGEAKDPCDP-NYTTPLHLAAKNGHREVIRQLLRA 211
LL+ +A N TPLH+A K +V+ LL+
Sbjct: 363 VTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Query: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQAS 270
G I T++G T +H AA G +V L+ G N N +TAL
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL----HMAARSGQ 478
Query: 271 REIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQ 314
E+ + L + ++ +A D LH L +A V +L+Q
Sbjct: 479 AEVVRYLVQDGAQVEAKAKDDQTPLHISARLG-KADIVQQLLQQ 521
Score = 113 bits (282), Expect = 1e-24
Identities = 74/235 (31%), Positives = 122/235 (51%), Gaps = 13/235 (5%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
D +ALH AA G ++ +LL+ +A + K NG PLH A + R++ + LLL+ A+
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
+ A + G P+H+AA GH + L+ H ++P N +T L +A G+ +V + L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
+ A +E +AKD TPLH++A+ G ++++QLL+ G N T +G T LH
Sbjct: 486 VQDG---AQVEAKAKDD-----QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
+A G +V LL+ G ++I T L + ++ E+ LL + S
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY----GKLEVANLLLQKS 588
Score = 112 bits (281), Expect = 2e-24
Identities = 71/234 (30%), Positives = 116/234 (49%), Gaps = 9/234 (3%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
K+ N N + +GF+ LH A ++++ LLL+ A++ +G+ P+H AA+ G +
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 98 VRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACE 157
V L+ A+ N ++ G+ LH+AA+ G EV L+Q + K +TPL ++
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 158 FGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR 217
G+ + Q LL +G + + + TPLHL+A+ GH +V LL G ++
Sbjct: 509 LGKADIVQQLLQ--------QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQAS 270
TK G T LH AA YGK EV LLL+ + T L + + + +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614
Score = 110 bits (274), Expect = 1e-23
Identities = 72/216 (33%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
G + LH AA + ++ LLL+ A+ NG PLH AA + +++ LL A
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL 168
NA + G +HLAAQ GH ++ +LL +N L NK+ TPL LA + R+ VA++L+
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 169 NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHE 227
N +G D TPLH+ G+ +++ LL+ ++N +TK G T LH+
Sbjct: 718 N--------QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQ 769
Query: 228 AALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
AA G T ++ +LL+ N TAL I +
Sbjct: 770 AAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
Score = 109 bits (273), Expect = 1e-23
Identities = 79/295 (26%), Positives = 139/295 (47%), Gaps = 22/295 (7%)
Query: 3 REQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSL 62
+ +D + + G +G +++V + +L TK +G S LH A G L
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK---------NGLSPLHMATQGDHL 347
Query: 63 ELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLA 122
+ LLL+ VD ++ + LH AA G + ++LL A NA +L+G PLH+A
Sbjct: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407
Query: 123 AQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAK 182
+ +V E+LL+H ++ V ++ TP+ +A G + + L++ G +
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH--------HGASP 459
Query: 183 DPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLL 241
+ + T LH+AA++G EV+R L++ G ++ + K T LH +A GK ++V+ LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 242 EGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLH 296
+ G N T T L + + + ++ L + L + K F LH
Sbjct: 520 QQGASPNAATTSGYTPLHL----SAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570
Score = 108 bits (270), Expect = 3e-23
Identities = 86/287 (29%), Positives = 133/287 (46%), Gaps = 51/287 (17%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L LA K G V V +L+ + NV+ G +ALH A+L G E++
Sbjct: 78 LHLASKEGHVEVVSELLQR-------------EANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYG 126
+L+ A V+ + NG PL+ AA + LE V+ LL A+ + A+ DG PL +A Q G
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 127 HYEV-----------------------------SEMLLQHQSNPCLVNKAKKTPLDLACE 157
H +V + +LLQ+ +N + +K+ TPL +A
Sbjct: 185 HDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244
Query: 158 FGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR 217
+G + VA LLLN A D N TPLH+A+K G+ +++ LL G +I+
Sbjct: 245 YGNINVATLLLN--------RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
+T+ G T LH A G +VV +LL+ + + + L + Q
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Score = 100 bits (249), Expect = 8e-21
Identities = 72/215 (33%), Positives = 113/215 (52%), Gaps = 15/215 (6%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G +ALH A+ G +E+++ LL+ +A VD G LH A+ G+ E V+
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L+ A VNA S +G PL++AAQ H EV + LL + ++ L + TPL +A + G
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQT 219
+V LLL + +G+ + P LH+AA+ + LL+ + ++
Sbjct: 185 HDQVVSLLLEND-----TKGKVRLPA-------LHIAARKDDTKAAALLLQNDNNADVES 232
Query: 220 KTG-TALHEAALYGKTEVVRLLLE--GGVDVNIRN 251
K+G T LH AA YG V LLL VD RN
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
Score = 94.4 bits (233), Expect = 6e-19
Identities = 66/194 (34%), Positives = 95/194 (48%), Gaps = 9/194 (4%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
+G++ LH AA +++ LLE A + G+ +H AA +G ++ V LLL +A
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
VN ++ G PLHLAAQ V+E+L+ ++ K TPL + C +G +K+ L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
L A + + K N TPLH AA+ GH +I LL+ N T G TAL
Sbjct: 750 LQHS---AKVNAKTK-----NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Query: 227 EAALYGKTEVVRLL 240
A G VV L
Sbjct: 802 IARRLGYISVVDTL 815
Score = 79.0 bits (193), Expect = 3e-14
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 9/187 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+ N G +++H AA G +++++LLL A V++ + +G+ PLH AA + R+ +
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEV 715
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ A V+A + G PLH+ YG+ ++ LLQH + K TPL A + G
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGH 775
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ +LL ++ + + N T L +A + G+ V+ L+ E T
Sbjct: 776 THIINVLLQNN--------ASPNELTVNGNTALGIARRLGYISVV-DTLKIVTEETMTTT 826
Query: 221 TGTALHE 227
T T H+
Sbjct: 827 TVTEKHK 833
Score = 78.6 bits (192), Expect = 3e-14
Identities = 73/267 (27%), Positives = 125/267 (46%), Gaps = 23/267 (8%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
KR + +D ++ AA G LE ++ ++I + NG+ LH A+ +G +E
Sbjct: 30 KRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEV 89
Query: 98 VRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACE 157
V LL+ A V+AA+ G LH+A+ G EV ++L+ + +N ++ TPL +A +
Sbjct: 90 VSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ 149
Query: 158 FGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR 217
L+V + LL++ G ++ + TPL +A + GH +V+ LL E +
Sbjct: 150 ENHLEVVKFLLDN--------GASQSLATEDGFTPLAVALQQGHDQVVSLLL----ENDT 197
Query: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQL 276
+ K ALH AA T+ LLL+ + ++ + T L I +
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN---------- 247
Query: 277 LREASGILKVRALKDFWNLHDPTALNV 303
+ A+ +L A DF +D T L+V
Sbjct: 248 INVATLLLNRAAAVDFTARNDITPLHV 274
Score = 75.5 bits (184), Expect = 3e-13
Identities = 47/135 (34%), Positives = 68/135 (50%), Gaps = 2/135 (1%)
Query: 33 LLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQ 92
LLG + NVN + G + LH AA + + +L+ A VD + G PLH
Sbjct: 683 LLG--RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHY 740
Query: 93 GRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPL 152
G ++ V LL+ SA VNA + +G PLH AAQ GH + +LLQ+ ++P + T L
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 153 DLACEFGRLKVAQLL 167
+A G + V L
Sbjct: 801 GIARRLGYISVVDTL 815
Score = 35.0 bits (79), Expect = 0.43
Identities = 55/206 (26%), Positives = 76/206 (36%), Gaps = 25/206 (12%)
Query: 855 RSQSFALRARRKGPPP---PPPKRLSSVS-----GPSPEPPPLDESPGPKEGATGPRRRT 906
R + R +++ P P P L VS G SP P E+P +E + +T
Sbjct: 3129 RGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTP---ETPSSEEVSYEFTSKT 3185
Query: 907 LSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIK---QR 963
+ PG P+P S+ EEE + T + + E E N K QR
Sbjct: 3186 PDSLI--AYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQR 3243
Query: 964 PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTAL--------LAFGVASAT 1015
PK E P PP LD + ESD +E + ++ L LA V
Sbjct: 3244 PKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQ 3303
Query: 1016 PGPAAPLPSPTPGESPPASSLPQPEP 1041
P P P +S S+ QP P
Sbjct: 3304 PPSPVP-PGADVSDSSDDESIYQPVP 3328
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 117 bits (293), Expect = 7e-26
Identities = 100/312 (32%), Positives = 138/312 (44%), Gaps = 71/312 (22%)
Query: 4 EQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSA--LHHAALGGS 61
++ L+ A K GDV V+KL +VN +D +G + LH AA
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQ--------------SVNCRDIEGRQSTPLHFAAGYNR 538
Query: 62 LELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHL 121
+ ++ LL+ A V KD G+ PLH A G E LL++ A VN A L PLH
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
Query: 122 AAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEA 181
AA G YE+ ++LLQH ++P N+ TPLDL + G + LL ALL+
Sbjct: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGD---AALLDAAK 654
Query: 182 K----------DPCDPN-------YTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-- 222
K P + N ++TPLHLAA + EV LL+ G ++N Q K G
Sbjct: 655 KGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLI 714
Query: 223 --------------------------------TALHEAALYGKTEVVRLLLEGGVDVNIR 250
T LHEAA G+T++ LLL G D ++
Sbjct: 715 PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK 774
Query: 251 NTYNQTALDIVN 262
N QT LD+V+
Sbjct: 775 NQEGQTPLDLVS 786
Score = 103 bits (256), Expect = 1e-21
Identities = 91/270 (33%), Positives = 125/270 (46%), Gaps = 30/270 (11%)
Query: 5 QDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSA--LHHAALGGSL 62
++L A +NGDV V++LV K VN +D G + LH AA G
Sbjct: 26 RELFEACRNGDVERVKRLVTPEK--------------VNSRDTAGRKSTPLHFAAGFGRK 71
Query: 63 ELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLA 122
+++ LL+ A V +D G+ PLH A G E V LLLR A NA PLH A
Sbjct: 72 DVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
Query: 123 AQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDL------ACEFGRLKVAQLLL-----NSH 171
A G +V +LLQH + P + N +T LDL A G K +LL N
Sbjct: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEE 191
Query: 172 LCVALLE--GEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEA 228
+ALL D +TPLHLAA ++++ LL+ G +++ + K LH A
Sbjct: 192 KMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNA 251
Query: 229 ALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
YG EV LL++ G VN + + T L
Sbjct: 252 CSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/354 (27%), Positives = 148/354 (41%), Gaps = 67/354 (18%)
Query: 10 AVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSA--LHHAALGGSLELIAL 67
AV G+ + L + + K++ LNVN +DG + LH AA ++++ L
Sbjct: 170 AVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQL 229
Query: 68 LLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGH 127
LL+ A V KD + PLH A G E LL++ A VNA L PLH AA
Sbjct: 230 LLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
Query: 128 YEVSEMLLQHQSNPCLVNKAKKTPLD----------LACEFGRLKVAQLL-------LNS 170
EV +LL + ++P L+N K+ +D LA EF + Q +
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349
Query: 171 HLCVALLE-------------------GEAKDPCD-------------PNYTTPLHLAAK 198
HL + ++ + K C+ + TPLH+A++
Sbjct: 350 HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
H +V+ +++ ++N G T+LH AA G + RLLL G D NI + TA
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469
Query: 258 LDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITV 311
L + N+ ++QLL+E + A + +AGDV TV
Sbjct: 470 LQMGNE--------NVQQLLQEGISLGNSEADRQLLEA-------AKAGDVETV 508
Score = 88.6 bits (218), Expect = 3e-17
Identities = 85/298 (28%), Positives = 123/298 (41%), Gaps = 44/298 (14%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
K N+N + + + LH A+ +++ ++++ +A V+ D+ G LH AA+ G L+
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
Query: 98 VRLLLRASAAVNAASLDGQIPLHL--------------------------AAQYGHYEVS 131
RLLL N SL G L + AA+ G E
Sbjct: 449 CRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETV 508
Query: 132 EMLLQHQSNPCL-VNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+ L QS C + + TPL A + R+ V + LL G D
Sbjct: 509 KKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ--------HGADVHAKDKGGL 560
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNI 249
PLH A GH EV L++ G +N T LHEAA GK E+ +LLL+ G D
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK 620
Query: 250 RNTYNQTALDIVNQFTTSQASREIKQLLREASGIL---KVRALKDFWNLHDPTALNVR 304
+N T LD+V T +I+ LLR + +L K L L P +N R
Sbjct: 621 KNRDGNTPLDLVKDGDT-----DIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673
Score = 72.0 bits (175), Expect = 3e-12
Identities = 49/129 (37%), Positives = 64/129 (49%), Gaps = 9/129 (6%)
Query: 148 KKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQ 207
K TPL A FGR V + LL + G D PLH A GH EV+
Sbjct: 58 KSTPLHFAAGFGRKDVVEYLLQN--------GANVQARDDGGLIPLHNACSFGHAEVVNL 109
Query: 208 LLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
LLR G + N R T LHEAA+ GK +V +LL+ G + IRNT +TALD+ +
Sbjct: 110 LLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAK 169
Query: 267 SQASREIKQ 275
+ + E K+
Sbjct: 170 AVLTGEYKK 178
Score = 37.7 bits (86), Expect = 0.066
Identities = 16/41 (39%), Positives = 30/41 (73%)
Query: 586 SMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGL 626
++ ++ ++ +EL+EIG+N GH+ KL+ GV+RL ++GL
Sbjct: 900 TLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGL 940
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 117 bits (292), Expect = 9e-26
Identities = 88/258 (34%), Positives = 131/258 (50%), Gaps = 22/258 (8%)
Query: 4 EQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLE 63
+ L+ A+ NGD V+ L+ K + +VN+QD + + LH AA G E
Sbjct: 9 QPSLVQAIFNGDPDEVRALIFKKE-------------DVNFQDNEKRTPLHAAAYLGDAE 55
Query: 64 LIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAA 123
+I LL+ + A V+ KDS + PLH A E V++LL+ SA VNA + Q PLH+AA
Sbjct: 56 IIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAA 115
Query: 124 QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKD 183
+ +E L+ SN + ++A +T L A G ++ +LLL+ G +
Sbjct: 116 ANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS--------RGANIN 167
Query: 184 PCDPNYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLE 242
D +H AA GH EV++ L+ G E+ + K+ T LH AA G VV+ LL+
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 243 GGVDVNIRNTYNQTALDI 260
GVD+N N Y T L +
Sbjct: 228 LGVDMNEPNAYGNTPLHV 245
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/222 (31%), Positives = 113/222 (50%), Gaps = 12/222 (5%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA--WQGRLEP 97
+++N +A G + LH A G ++ L++ A V+ K+ G PLH+AA G L
Sbjct: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-C 288
Query: 98 VRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACE 157
+ LL+ A VN S DG+ PLH+ A +G + S+ ++Q + +K TPL +A
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 158 FGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR 217
+G +LL+N+ + G + PLHLAA +G + R+LL +G +I+
Sbjct: 349 YGH----ELLINT----LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
G T LH AA G E + LLL G D N ++ + ++ L
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Score = 93.2 bits (230), Expect = 1e-18
Identities = 76/263 (28%), Positives = 119/263 (45%), Gaps = 43/263 (16%)
Query: 41 NVNYQDADGFSALHHAALGGSL-ELIALLLEAQATVDIKDSNGMRPLHYAAWQGRL---- 95
+VN D G + LH+AA + + + LL A I+D G +HY+A G
Sbjct: 463 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 522
Query: 96 -----EPVRLLLRASAAVNAASLDGQI---PLHLAAQYGHYEVSEMLLQHQSNPCLVNKA 147
P+ +L+ S + D + PLHLAA +GH++ E+L+Q + + N +
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582
Query: 148 KKTPLDLACEFGRLKVAQLLLNSHL------------------------CVALLEGEAK- 182
+TPLDLA G ++ +L+N C+ LL G A+
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
Query: 183 ----DPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVV 237
D D N TPL L+ NGH + + LL G ++ + K G TALH A+ G E V
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV 702
Query: 238 RLLLEGGVDVNIRNTYNQTALDI 260
LL+ G +R++ +T + +
Sbjct: 703 DALLQHGAKCLLRDSRGRTPIHL 725
Score = 91.7 bits (226), Expect = 4e-18
Identities = 72/253 (28%), Positives = 111/253 (43%), Gaps = 43/253 (16%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
N+N D A+H AA G +E++ LL+ A V KD PLH AA G + V+
Sbjct: 165 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 224
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYG--------------------------HYEVS--- 131
LL +N + G PLH+A G H+ +
Sbjct: 225 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTH 284
Query: 132 -----EMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCD 186
E+L+ + ++ + +K KTPL + GR +Q ++ S G D D
Sbjct: 285 GALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS--------GAVIDCED 336
Query: 187 PNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGT-ALHEAALYGKTEVVRLLLEGGV 245
N TPLH+AA+ GH +I L+ +G + ++ G LH AAL G ++ R LL G
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 246 DVNIRNTYNQTAL 258
D++ + + +T L
Sbjct: 397 DIDTPDDFGRTCL 409
Score = 87.0 bits (214), Expect = 1e-16
Identities = 73/223 (32%), Positives = 98/223 (43%), Gaps = 16/223 (7%)
Query: 33 LLGSTKRLNVNYQDAD--GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA 90
LL S ++ N AD G++ALH A G + LLLE Q + N PLH A
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE-QEVFQKTEGNAFSPLHCAV 796
Query: 91 WQGRLEPVRLLLRASAA--VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 148
+L+ A VNA G+ PLH AA H E ++LL H + V+
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTG 856
Query: 149 KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208
KTPL +A E G+ ++L++S L+ +K+ T LHLA GH +
Sbjct: 857 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN-------TALHLACSKGHETSALLI 909
Query: 209 LRAGIEINRQTKTG----TALHEAALYGKTEVVRLLLEGGVDV 247
L + N T T LH AA G T VV+ LL G V
Sbjct: 910 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Score = 84.0 bits (206), Expect = 8e-16
Identities = 75/240 (31%), Positives = 100/240 (41%), Gaps = 34/240 (14%)
Query: 53 LHHAALGGSLELIALLL---EAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVN 109
+H AA G E + LL+ E Q VDI+D NG PL + G + V LL A V+
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680
Query: 110 AASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLN 169
A G+ LH A GH E + LLQH + L + +TP+ L+ G + V LL
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740
Query: 170 S---------------------------HLCV-ALLEGEAKDPCDPNYTTPLHLAAKN-- 199
S CV LLE E + N +PLH A N
Sbjct: 741 SAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDN 800
Query: 200 -GHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
G E++ L A I +K T LH AA E ++LLL VN ++ +T L
Sbjct: 801 EGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Score = 75.9 bits (185), Expect = 2e-13
Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 9/190 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN + DG + LH AL G ++++ A +D +D NG PLH AA G +
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ + A + G PLHLAA G + LL + + +T L A G
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
L+ LLLN+ G + D +PLH AA N + + + L+ +G +N +
Sbjct: 418 LECLNLLLNT--------GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 221 TG-TALHEAA 229
G T LH AA
Sbjct: 470 RGCTPLHYAA 479
Score = 75.1 bits (183), Expect = 4e-13
Identities = 82/320 (25%), Positives = 132/320 (41%), Gaps = 61/320 (19%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L+L+V NG V L+ K NV+ +D G +ALH A+ G E +
Sbjct: 657 LMLSVLNGHTDCVYSLL-------------NKGANVDAKDKWGRTALHRGAVTGHEECVD 703
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNA----ASLDGQIPLHLA 122
LL+ A ++DS G P+H +A G + + LL+++A+++A A G LH A
Sbjct: 704 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWA 763
Query: 123 AQYGHYEVSEMLLQHQS-------------------------------NPCLVNKAK--- 148
GH E+LL+ + +VN
Sbjct: 764 CYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
Query: 149 KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 208
+TPL A ++ QLLL+ + V ++ K TPL +AA+NG + L
Sbjct: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK--------TPLMMAAENGQTNTVEML 875
Query: 209 LR-AGIEINRQTKT-GTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
+ A E+ Q + TALH A G L+LE D N+ N N ++
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAAR 935
Query: 267 SQASREIKQLLREASGILKV 286
+ + +++LL + + +L V
Sbjct: 936 NGLTMVVQELLGKGASVLAV 955
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/152 (28%), Positives = 63/152 (41%), Gaps = 38/152 (25%)
Query: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
VN D+ G + LH AA +E + LLL A V+ DS G PL AA G+ V +L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 102 LRASAA-------------------------------------VNAASLDGQIPLHLAAQ 124
+ +++A +NA + Q PLH+AA+
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAAR 935
Query: 125 YGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
G V + LL ++ V++ TP LAC
Sbjct: 936 NGLTMVVQELLGKGASVLAVDENGYTPA-LAC 966
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 117 bits (292), Expect = 9e-26
Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 15/269 (5%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
+G++ LH +A G +++ ++LLEA A + G PLH AA G L+ +LLL+ AA
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 567
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
++A +G PLH+AA Y + +V+ +LL+ ++P K TPL +A + ++++A L
Sbjct: 568 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
LN G + TPLHLA++ GH +++ LL G I+ TK+G T+LH
Sbjct: 628 LN--------YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 679
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
AA K V +L + G D + T L + + + + LL++ + +
Sbjct: 680 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN---VKMVNFLLKQGANV-NA 735
Query: 287 RALKDFWNLHDPTALNVRAGDVITVLEQH 315
+ + LH A +I VL QH
Sbjct: 736 KTKNGYTPLHQ--AAQQGHTHIINVLLQH 762
Score = 114 bits (285), Expect = 6e-25
Identities = 86/274 (31%), Positives = 127/274 (46%), Gaps = 59/274 (21%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
G + +H AA G L ++ LLL+ A+ D+ + G LH AA G++E VR LLR A V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP--------------------------- 141
+A + + Q PLH+A++ G E+ ++LLQH ++P
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529
Query: 142 ------CLVNKAKKTPLDLACEFGRLKVAQLLL------------------------NSH 171
L K TPL +A ++G L VA+LLL N
Sbjct: 530 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589
Query: 172 LCVALLE-GEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAA 229
+ + LLE G + N TPLH+AAK ++ LL G E N TK G T LH A+
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649
Query: 230 LYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
G T++V LLL+ G ++++ T+L + Q
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Score = 112 bits (281), Expect = 2e-24
Identities = 75/213 (35%), Positives = 117/213 (54%), Gaps = 10/213 (4%)
Query: 31 TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA 90
TKLL KR N N + +GF+ LH A ++++ LL++ A++ +G+ P+H AA
Sbjct: 360 TKLL-LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 418
Query: 91 WQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKT 150
+ G L V LLL+ A+ + ++ G+ LH+AA+ G EV LL++ + + ++T
Sbjct: 419 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 478
Query: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210
PL +A G+ ++ QLLL H+ D N TPLH++A+ G +V LL
Sbjct: 479 PLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQVDVASVLLE 530
Query: 211 AGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 242
AG + TK G T LH AA YG +V +LLL+
Sbjct: 531 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Score = 108 bits (270), Expect = 3e-23
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 26/241 (10%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
GF+ LH AA GSL++ LLL+ +A D NG+ PLH AA + LLL A+
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL 168
+A + +G PLH+AA+ +++ LL + + +V K TPL LA + G + LLL
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 169 NS---------------HLC----------VALLEGEAKDPCDPNYTTPLHLAAKNGHRE 203
+ HL + G +D TPL +A G+ +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721
Query: 204 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262
++ LL+ G +N +TK G T LH+AA G T ++ +LL+ G N TAL I
Sbjct: 722 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Query: 263 Q 263
+
Sbjct: 782 R 782
Score = 108 bits (269), Expect = 4e-23
Identities = 87/303 (28%), Positives = 136/303 (44%), Gaps = 32/303 (10%)
Query: 39 RLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPV 98
++ VN GF+ LH AA G++ + LLL A VD NG+ PLH A+ +G V
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 261
Query: 99 RLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEF 158
+LLL ++A + DG PLH AA+ GH +V E+LL+ + K +PL +A +
Sbjct: 262 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321
Query: 159 GRLKVAQLLLNSHLCV------------------------ALLEGEAKDPCDP-NYTTPL 193
++ + LL V LL+ A N TPL
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 381
Query: 194 HLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNT 252
H+A K +V+ L++ G I T++G T +H AA G +V LLL+ G ++ N
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 441
Query: 253 YNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVL 312
+TAL E+ + L ++ RA ++ LH A + +++ +L
Sbjct: 442 RGETAL----HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLL 495
Query: 313 EQH 315
QH
Sbjct: 496 LQH 498
Score = 105 bits (262), Expect = 3e-22
Identities = 78/259 (30%), Positives = 135/259 (52%), Gaps = 19/259 (7%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
D +ALH AA G + LLL+ +A + + NG PLH A + R++ + LL++ A+
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
+ A + G P+H+AA GH + +LLQ+ ++P + N +T L +A G+++V + L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
L + AL++ A++ TPLH+A++ G E+++ LL+ + T G T LH
Sbjct: 463 LRNG---ALVDARAREE-----QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
+A G+ +V +LLE G ++ T L + ++ S ++ +LL L+
Sbjct: 515 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKY----GSLDVAKLL------LQR 564
Query: 287 RALKDFWNLHDPTALNVRA 305
RA D + T L+V A
Sbjct: 565 RAAADSAGKNGLTPLHVAA 583
Score = 96.7 bits (239), Expect = 1e-19
Identities = 69/212 (32%), Positives = 103/212 (48%), Gaps = 9/212 (4%)
Query: 30 KTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYA 89
K LL K + + +G++ LH AA +++ + LL A +I G+ PLH A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 90 AWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149
+ +G + V LLL A ++ ++ G LHLAAQ V+++L +H ++ K
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
TPL +AC +G +K+ LL +G + N TPLH AA+ GH +I LL
Sbjct: 709 TPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 210 RAGIEINRQTKTG-TALHEAALYGKTEVVRLL 240
+ G + N T G TAL A G VV L
Sbjct: 761 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 95.1 bits (235), Expect = 3e-19
Identities = 75/266 (28%), Positives = 129/266 (48%), Gaps = 25/266 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G +ALH AA G + L+ LL ++VD G LH A+ G+ E V+
Sbjct: 34 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 93
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L++ A +NA S +G PL++AAQ H +V + LL++ +N + TPL +A + G
Sbjct: 94 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL--------RA 211
+ +LL + +G+ + P LH+AA+ + LL ++
Sbjct: 154 HNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSAALLLQNDHNADVQS 201
Query: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQAS 270
+ +NR T++G T LH AA YG V LLL G V+ T L + ++ + +
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK----RGN 257
Query: 271 REIKQLLREASGILKVRALKDFWNLH 296
+ +LL + G + + LH
Sbjct: 258 TNMVKLLLDRGGQIDAKTRDGLTPLH 283
Score = 81.3 bits (199), Expect = 5e-15
Identities = 70/218 (32%), Positives = 100/218 (45%), Gaps = 17/218 (7%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDS--------NGMRPLHYAAWQGRLEPVRLLLR 103
ALH AA + ALLL+ D++ +G PLH AA G + LLL
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 104 ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKV 163
AAV+ + +G PLH+A++ G+ + ++LL + TPL A G +V
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293
Query: 164 AQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG- 222
+LLL A L K N +PLH+AA+ H E ++ LL+ ++ T
Sbjct: 294 VELLLERG---APLLARTK-----NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 345
Query: 223 TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
TALH AA G V +LLL+ + N R T L I
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 117 bits (292), Expect = 9e-26
Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 15/269 (5%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
+G++ LH +A G +++ ++LLEA A + G PLH AA G L+ +LLL+ AA
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
++A +G PLH+AA Y + +V+ +LL+ ++P K TPL +A + ++++A L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
LN G + TPLHLA++ GH +++ LL G I+ TK+G T+LH
Sbjct: 649 LN--------YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
AA K V +L + G D + T L + + + + LL++ + +
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN---VKMVNFLLKQGANV-NA 756
Query: 287 RALKDFWNLHDPTALNVRAGDVITVLEQH 315
+ + LH A +I VL QH
Sbjct: 757 KTKNGYTPLHQ--AAQQGHTHIINVLLQH 783
Score = 114 bits (285), Expect = 6e-25
Identities = 86/274 (31%), Positives = 127/274 (46%), Gaps = 59/274 (21%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
G + +H AA G L ++ LLL+ A+ D+ + G LH AA G++E VR LLR A V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP--------------------------- 141
+A + + Q PLH+A++ G E+ ++LLQH ++P
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 142 ------CLVNKAKKTPLDLACEFGRLKVAQLLL------------------------NSH 171
L K TPL +A ++G L VA+LLL N
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610
Query: 172 LCVALLE-GEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAA 229
+ + LLE G + N TPLH+AAK ++ LL G E N TK G T LH A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 230 LYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
G T++V LLL+ G ++++ T+L + Q
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Score = 112 bits (281), Expect = 2e-24
Identities = 75/213 (35%), Positives = 117/213 (54%), Gaps = 10/213 (4%)
Query: 31 TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA 90
TKLL KR N N + +GF+ LH A ++++ LL++ A++ +G+ P+H AA
Sbjct: 381 TKLL-LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 91 WQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKT 150
+ G L V LLL+ A+ + ++ G+ LH+AA+ G EV LL++ + + ++T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210
PL +A G+ ++ QLLL H+ D N TPLH++A+ G +V LL
Sbjct: 500 PLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 211 AGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 242
AG + TK G T LH AA YG +V +LLL+
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 108 bits (270), Expect = 3e-23
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 26/241 (10%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
GF+ LH AA GSL++ LLL+ +A D NG+ PLH AA + LLL A+
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL 168
+A + +G PLH+AA+ +++ LL + + +V K TPL LA + G + LLL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 169 NS---------------HLC----------VALLEGEAKDPCDPNYTTPLHLAAKNGHRE 203
+ HL + G +D TPL +A G+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 204 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262
++ LL+ G +N +TK G T LH+AA G T ++ +LL+ G N TAL I
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 263 Q 263
+
Sbjct: 803 R 803
Score = 108 bits (269), Expect = 4e-23
Identities = 87/303 (28%), Positives = 136/303 (44%), Gaps = 32/303 (10%)
Query: 39 RLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPV 98
++ VN GF+ LH AA G++ + LLL A VD NG+ PLH A+ +G V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 99 RLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEF 158
+LLL ++A + DG PLH AA+ GH +V E+LL+ + K +PL +A +
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 159 GRLKVAQLLLNSHLCV------------------------ALLEGEAKDPCDP-NYTTPL 193
++ + LL V LL+ A N TPL
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 194 HLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNT 252
H+A K +V+ L++ G I T++G T +H AA G +V LLL+ G ++ N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 253 YNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVL 312
+TAL E+ + L ++ RA ++ LH A + +++ +L
Sbjct: 463 RGETAL----HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLL 516
Query: 313 EQH 315
QH
Sbjct: 517 LQH 519
Score = 105 bits (262), Expect = 3e-22
Identities = 78/259 (30%), Positives = 135/259 (52%), Gaps = 19/259 (7%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
D +ALH AA G + LLL+ +A + + NG PLH A + R++ + LL++ A+
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
+ A + G P+H+AA GH + +LLQ+ ++P + N +T L +A G+++V + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
L + AL++ A++ TPLH+A++ G E+++ LL+ + T G T LH
Sbjct: 484 LRNG---ALVDARAREE-----QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
+A G+ +V +LLE G ++ T L + ++ S ++ +LL L+
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKY----GSLDVAKLL------LQR 585
Query: 287 RALKDFWNLHDPTALNVRA 305
RA D + T L+V A
Sbjct: 586 RAAADSAGKNGLTPLHVAA 604
Score = 96.7 bits (239), Expect = 1e-19
Identities = 69/212 (32%), Positives = 103/212 (48%), Gaps = 9/212 (4%)
Query: 30 KTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYA 89
K LL K + + +G++ LH AA +++ + LL A +I G+ PLH A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 90 AWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149
+ +G + V LLL A ++ ++ G LHLAAQ V+++L +H ++ K
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
TPL +AC +G +K+ LL +G + N TPLH AA+ GH +I LL
Sbjct: 730 TPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 210 RAGIEINRQTKTG-TALHEAALYGKTEVVRLL 240
+ G + N T G TAL A G VV L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 95.1 bits (235), Expect = 3e-19
Identities = 75/266 (28%), Positives = 129/266 (48%), Gaps = 25/266 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G +ALH AA G + L+ LL ++VD G LH A+ G+ E V+
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L++ A +NA S +G PL++AAQ H +V + LL++ +N + TPL +A + G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL--------RA 211
+ +LL + +G+ + P LH+AA+ + LL ++
Sbjct: 175 HNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQAS 270
+ +NR T++G T LH AA YG V LLL G V+ T L + ++ + +
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK----RGN 278
Query: 271 REIKQLLREASGILKVRALKDFWNLH 296
+ +LL + G + + LH
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLH 304
Score = 81.3 bits (199), Expect = 5e-15
Identities = 70/218 (32%), Positives = 100/218 (45%), Gaps = 17/218 (7%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDS--------NGMRPLHYAAWQGRLEPVRLLLR 103
ALH AA + ALLL+ D++ +G PLH AA G + LLL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 104 ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKV 163
AAV+ + +G PLH+A++ G+ + ++LL + TPL A G +V
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 164 AQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG- 222
+LLL A L K N +PLH+AA+ H E ++ LL+ ++ T
Sbjct: 315 VELLLERG---APLLARTK-----NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 366
Query: 223 TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
TALH AA G V +LLL+ + N R T L I
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 117 bits (292), Expect = 9e-26
Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 15/269 (5%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
+G++ LH +A G +++ ++LLEA A + G PLH AA G L+ +LLL+ AA
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
++A +G PLH+AA Y + +V+ +LL+ ++P K TPL +A + ++++A L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
LN G + TPLHLA++ GH +++ LL G I+ TK+G T+LH
Sbjct: 649 LN--------YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
AA K V +L + G D + T L + + + + LL++ + +
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN---VKMVNFLLKQGANV-NA 756
Query: 287 RALKDFWNLHDPTALNVRAGDVITVLEQH 315
+ + LH A +I VL QH
Sbjct: 757 KTKNGYTPLHQ--AAQQGHTHIINVLLQH 783
Score = 114 bits (285), Expect = 6e-25
Identities = 86/274 (31%), Positives = 127/274 (46%), Gaps = 59/274 (21%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
G + +H AA G L ++ LLL+ A+ D+ + G LH AA G++E VR LLR A V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP--------------------------- 141
+A + + Q PLH+A++ G E+ ++LLQH ++P
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 142 ------CLVNKAKKTPLDLACEFGRLKVAQLLL------------------------NSH 171
L K TPL +A ++G L VA+LLL N
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610
Query: 172 LCVALLE-GEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAA 229
+ + LLE G + N TPLH+AAK ++ LL G E N TK G T LH A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 230 LYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 263
G T++V LLL+ G ++++ T+L + Q
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Score = 112 bits (281), Expect = 2e-24
Identities = 75/213 (35%), Positives = 117/213 (54%), Gaps = 10/213 (4%)
Query: 31 TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA 90
TKLL KR N N + +GF+ LH A ++++ LL++ A++ +G+ P+H AA
Sbjct: 381 TKLL-LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439
Query: 91 WQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKT 150
+ G L V LLL+ A+ + ++ G+ LH+AA+ G EV LL++ + + ++T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499
Query: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210
PL +A G+ ++ QLLL H+ D N TPLH++A+ G +V LL
Sbjct: 500 PLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 211 AGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 242
AG + TK G T LH AA YG +V +LLL+
Sbjct: 552 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 108 bits (270), Expect = 3e-23
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 26/241 (10%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV 108
GF+ LH AA GSL++ LLL+ +A D NG+ PLH AA + LLL A+
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
Query: 109 NAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL 168
+A + +G PLH+AA+ +++ LL + + +V K TPL LA + G + LLL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 169 NS---------------HLC----------VALLEGEAKDPCDPNYTTPLHLAAKNGHRE 203
+ HL + G +D TPL +A G+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 204 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262
++ LL+ G +N +TK G T LH+AA G T ++ +LL+ G N TAL I
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 263 Q 263
+
Sbjct: 803 R 803
Score = 108 bits (269), Expect = 4e-23
Identities = 87/303 (28%), Positives = 136/303 (44%), Gaps = 32/303 (10%)
Query: 39 RLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPV 98
++ VN GF+ LH AA G++ + LLL A VD NG+ PLH A+ +G V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 99 RLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEF 158
+LLL ++A + DG PLH AA+ GH +V E+LL+ + K +PL +A +
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 159 GRLKVAQLLLNSHLCV------------------------ALLEGEAKDPCDP-NYTTPL 193
++ + LL V LL+ A N TPL
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 194 HLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNT 252
H+A K +V+ L++ G I T++G T +H AA G +V LLL+ G ++ N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 253 YNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVL 312
+TAL E+ + L ++ RA ++ LH A + +++ +L
Sbjct: 463 RGETAL----HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLL 516
Query: 313 EQH 315
QH
Sbjct: 517 LQH 519
Score = 105 bits (262), Expect = 3e-22
Identities = 78/259 (30%), Positives = 135/259 (52%), Gaps = 19/259 (7%)
Query: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
D +ALH AA G + LLL+ +A + + NG PLH A + R++ + LL++ A+
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
+ A + G P+H+AA GH + +LLQ+ ++P + N +T L +A G+++V + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 226
L + AL++ A++ TPLH+A++ G E+++ LL+ + T G T LH
Sbjct: 484 LRNG---ALVDARAREE-----QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 227 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
+A G+ +V +LLE G ++ T L + ++ S ++ +LL L+
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKY----GSLDVAKLL------LQR 585
Query: 287 RALKDFWNLHDPTALNVRA 305
RA D + T L+V A
Sbjct: 586 RAAADSAGKNGLTPLHVAA 604
Score = 96.7 bits (239), Expect = 1e-19
Identities = 69/212 (32%), Positives = 103/212 (48%), Gaps = 9/212 (4%)
Query: 30 KTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYA 89
K LL K + + +G++ LH AA +++ + LL A +I G+ PLH A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 90 AWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149
+ +G + V LLL A ++ ++ G LHLAAQ V+++L +H ++ K
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
TPL +AC +G +K+ LL +G + N TPLH AA+ GH +I LL
Sbjct: 730 TPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 210 RAGIEINRQTKTG-TALHEAALYGKTEVVRLL 240
+ G + N T G TAL A G VV L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 95.1 bits (235), Expect = 3e-19
Identities = 75/266 (28%), Positives = 129/266 (48%), Gaps = 25/266 (9%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+++N + +G +ALH AA G + L+ LL ++VD G LH A+ G+ E V+
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L++ A +NA S +G PL++AAQ H +V + LL++ +N + TPL +A + G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL--------RA 211
+ +LL + +G+ + P LH+AA+ + LL ++
Sbjct: 175 HNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQAS 270
+ +NR T++G T LH AA YG V LLL G V+ T L + ++ + +
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK----RGN 278
Query: 271 REIKQLLREASGILKVRALKDFWNLH 296
+ +LL + G + + LH
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLH 304
Score = 81.3 bits (199), Expect = 5e-15
Identities = 70/218 (32%), Positives = 100/218 (45%), Gaps = 17/218 (7%)
Query: 52 ALHHAALGGSLELIALLLEAQATVDIKDS--------NGMRPLHYAAWQGRLEPVRLLLR 103
ALH AA + ALLL+ D++ +G PLH AA G + LLL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 104 ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKV 163
AAV+ + +G PLH+A++ G+ + ++LL + TPL A G +V
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 164 AQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG- 222
+LLL A L K N +PLH+AA+ H E ++ LL+ ++ T
Sbjct: 315 VELLLERG---APLLARTK-----NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL 366
Query: 223 TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
TALH AA G V +LLL+ + N R T L I
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Score = 46.6 bits (109), Expect = 1e-04
Identities = 79/337 (23%), Positives = 114/337 (33%), Gaps = 52/337 (15%)
Query: 682 GGGPEPLPLPPARSP--SQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP 739
G PEPLP A SP + IG+ Q++ + G P + + G E
Sbjct: 1742 GLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVK----GKEDV 1797
Query: 740 PKLCSSLPGQGPPPYVFMYPQGSPS----SPAPGPPPGAPWAFSYLAGPPAT---PPDPP 792
PK + P +P SPS APG P S L+ T PP P
Sbjct: 1798 PKKTTHRP----------HPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSP 1847
Query: 793 RPKRRSHS-------LSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSV 845
K HS R P ++ E PV S +T T R + +T
Sbjct: 1848 SSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPV-----SPSTKTERHSPVSSTKTERHP 1902
Query: 846 TPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRR 905
+P+ T + + R + PP P R SP P G T +
Sbjct: 1903 PVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKT--EKH 1960
Query: 906 TLSEPAGPSEPPGPPAPAGPASDTEEEEPGPE-------GTPPSRGSSGEGLPFAEEGNL 958
P+G +E P +P EE E G PS+ +G E
Sbjct: 1961 LPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTG-----LFEHKS 2015
Query: 959 TIKQRPKPAGP---PPRETPVPPGLDFNLTESDTVKR 992
+++P+ G + P+ + TE+ T+KR
Sbjct: 2016 AKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKR 2052
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 115 bits (289), Expect = 2e-25
Identities = 125/452 (27%), Positives = 159/452 (35%), Gaps = 93/452 (20%)
Query: 711 SQEQPAPQPSGGDP--SPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAP 768
SQE+ +P G+P +PPQ N P+G PP QGPPP PQG P P P
Sbjct: 24 SQEE-SPSLIAGNPQGAPPQGGNKPQGPPSPPG-----KPQGPPPQGGNQPQGPP--PPP 75
Query: 769 GPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYAT 828
G P G P P PP P +P+ P +GD P G G
Sbjct: 76 GKPQGPP---PQGGNKPQGPPPPGKPQGP--------PPQGDKSRSPRSPPGKPQGPPPQ 124
Query: 829 LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPS 883
+P P P G P+ + +GPPPP PP + + S S
Sbjct: 125 GGNQPQG-----------PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSS 173
Query: 884 PEPPPLDESPGPKEG------------ATGPRRRTLSEPAGP---SEPPGPPAPAGPASD 928
PP + P P+ G GP + ++P GP +P GPP S
Sbjct: 174 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQ 233
Query: 929 TEEEEPG-PEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPR-----ETPVPPGLDF 982
+ PG P+G PP G+ +G P KP GPPP+ + P PPG
Sbjct: 234 SARSPPGKPQGPPPQGGNQPQGPP---------PPPGKPQGPPPQGGNKPQGPPPPGKPQ 284
Query: 983 NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 1042
K R +S +P P P G P P +P
Sbjct: 285 GPPPQGGSKSR------------------SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326
Query: 1043 SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAG-TA 1101
P QG P P P +P PP G SA S PP P + G
Sbjct: 327 GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARS-------PPGKPQGPPQQEGNNPQG 379
Query: 1102 PKPVSVACTQLAFSGPKLAPRLGPRPVPPPRP 1133
P P + Q + P P+ PRP RP
Sbjct: 380 PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRP 411
Score = 97.4 bits (241), Expect = 7e-20
Identities = 100/346 (28%), Positives = 128/346 (36%), Gaps = 65/346 (18%)
Query: 655 EGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQ 714
+G + PR + G P Q GP P P P P Q G ++ Q
Sbjct: 104 QGDKSRSPR--SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ----------GGNKPQ 151
Query: 715 PAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA 774
P P PPQ N + PP QGPPP PQG P P PG P G
Sbjct: 152 GPPPPGKPQGPPPQGDNKSRSSRSPPG-----KPQGPPPQGGNQPQGPP--PPPGKPQGP 204
Query: 775 PWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGE-AEGPVGSTLGSYATLTRRP 833
P P PP P +P+ P +GD + + A P G G +P
Sbjct: 205 P---PQGGNKPQGPPPPGKPQGP--------PPQGDNKSQSARSPPGKPQGPPPQGGNQP 253
Query: 834 GRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPSPEPPP 888
P P G P+ + +GPPPP PP + S S S PP
Sbjct: 254 QG-----------PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPG 302
Query: 889 LDESPGPKEG------------ATGPRRRTLSEPAGP---SEPPGPPAPAGPASDTEEEE 933
+ P P+ G GP + ++P GP +P GPP G S +
Sbjct: 303 KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSP 362
Query: 934 PG-PEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPP 978
PG P+G P G++ +G P GN Q P PAG P+ P PP
Sbjct: 363 PGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAP-PAG-QPQGPPRPP 406
Score = 81.6 bits (200), Expect = 4e-15
Identities = 91/342 (26%), Positives = 117/342 (34%), Gaps = 63/342 (18%)
Query: 842 SPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT- 900
S +P+ G P+ + +GPP PP K GP P+ + P P G
Sbjct: 24 SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKP----QGPPPQGGNQPQGPPPPPGKPQ 79
Query: 901 GPRRRTLSEPAGP---SEPPGPPAPAGPASDTEEEEPG-PEGTPPSRGSSGEGLPFAEEG 956
GP + ++P GP +P GPP P G S + PG P+G PP G+ +G P
Sbjct: 80 GPPPQGGNKPQGPPPPGKPQGPP-PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP----- 133
Query: 957 NLTIKQRPKPAGPPPR-----ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGV 1011
KP GPPP+ + P PPG K R
Sbjct: 134 ----PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR------------------ 171
Query: 1012 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGL 1071
+S +P P P G P P +P P QG P P P +P PP G
Sbjct: 172 SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNK 231
Query: 1072 ESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPP 1131
SA S PP P P G P+ GP P P P
Sbjct: 232 SQSARS-------PPGKPQG--PPPQGGNQPQ------------GPPPPPGKPQGPPPQG 270
Query: 1132 RPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEG 1173
+ G PG+ Q Q S ++ K G Q G
Sbjct: 271 GNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312
Score = 68.6 bits (166), Expect = 4e-11
Identities = 75/296 (25%), Positives = 91/296 (30%), Gaps = 57/296 (19%)
Query: 669 GSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRG-----------SGHSQEQPAP 717
G P Q GP P P P ++ SR G+ + P P
Sbjct: 137 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPP 196
Query: 718 QPSGGDPSPPQERNLPEGTERPPK-------------LCSSLPG--QGPPPYVFMYPQGS 762
P PPQ N P+G P K S PG QGPPP PQG
Sbjct: 197 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGP 256
Query: 763 PSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST 822
P P PG P G P P PP P +P+ P P G + P G
Sbjct: 257 P--PPPGKPQGPP---PQGGNKPQGPPPPGKPQG-------PPPQGGSKSRSSRSPPGKP 304
Query: 823 LGSYATLTRRP-----------GRSALVRTSPSVTPTPAR--GTPRSQSFALRARRKGPP 869
G +P G P P P + G P R+ R P
Sbjct: 305 QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG 364
Query: 870 PPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGP 925
P + P PPP +P P+ +P GP PP P+ P
Sbjct: 365 KPQGPPQQEGNNPQGPPPPAGGNP------QQPQAPPAGQPQGPPRPPQGGRPSRP 414
Score = 39.3 bits (90), Expect = 0.023
Identities = 41/134 (30%), Positives = 47/134 (35%), Gaps = 33/134 (24%)
Query: 669 GSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRG------------SGHSQEQPA 716
G P Q GP P P P P Q G + +G G S+ + A
Sbjct: 302 GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGPPPQGGSKSRSA 359
Query: 717 PQPSGGDPSPP-QERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAP 775
P G PP QE N P+G PP P Q P P G P P P PP G
Sbjct: 360 RSPPGKPQGPPQQEGNNPQG---PPPPAGGNPQQPQAP-----PAGQPQGP-PRPPQG-- 408
Query: 776 WAFSYLAGPPATPP 789
G P+ PP
Sbjct: 409 -------GRPSRPP 415
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 115 bits (287), Expect = 3e-25
Identities = 92/293 (31%), Positives = 138/293 (47%), Gaps = 14/293 (4%)
Query: 5 QDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLEL 64
+D L + VT + LVA+ + +LL ++V+ Q A G++ L AA +L
Sbjct: 352 RDEELCIYENKVTPLHFLVAQGSVEQVRLL-LAHEVDVDCQTASGYTPLLIAAQDQQPDL 410
Query: 65 IALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQ 124
ALLL A + D +G PLH+AA G RLLL A V+A +G PLHLAAQ
Sbjct: 411 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ 470
Query: 125 YGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDP 184
V+ +L+ Q++P L KTPL +A FG + + +LL + +G D
Sbjct: 471 NNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS--------QGAELDA 522
Query: 185 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLLEG 243
N TPLHLA + G I+ LL++G + ++G LH AA GK + ++LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582
Query: 244 GVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLH 296
G + + T L + + EI LL E+ + ++ LH
Sbjct: 583 GASLELPTHQGWTPLHL----AAYKGHLEIIHLLAESHANMGALGAVNWTPLH 631
Score = 102 bits (255), Expect = 2e-21
Identities = 74/258 (28%), Positives = 122/258 (47%), Gaps = 42/258 (16%)
Query: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
+++ + N +A+G + LH AA G + L+ LL A +D + N PLH A +G++
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
++ LL++ A +A G PLH AA G Y + +MLL++ ++ L TPL LA
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
Query: 157 EFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEIN 216
G L++ LL SH + L N+T PLHLAA++G V+ LL+ G + N
Sbjct: 602 YKGHLEIIHLLAESHANMGALGAV-------NWT-PLHLAARHGEEAVVSALLQCGADPN 653
Query: 217 RQTKTG----------------------------------TALHEAALYGKTEVVRLLLE 242
++G T H AAL G T ++++L+E
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
Query: 243 GGVDVNIRNTYNQTALDI 260
G +++++ + T L +
Sbjct: 714 AGAQLDVQDGVSCTPLQL 731
Score = 89.0 bits (219), Expect = 3e-17
Identities = 72/237 (30%), Positives = 108/237 (45%), Gaps = 21/237 (8%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L LAV+ G V +Q L+ K A L D G+ LH AA G +
Sbjct: 531 LHLAVERGKVRAIQHLL-KSGAVPDAL------------DQSGYGPLHTAAARGKYLICK 577
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYG 126
+LL A++++ G PLH AA++G LE + LL + A + A PLHLAA++G
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637
Query: 127 HYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCD 186
V LLQ ++P ++ TPL LA + LL H V A++
Sbjct: 638 EEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANV-----HARNKVG 692
Query: 187 PNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEG 243
TP HLAA G+ +++ L+ AG +++ Q + AL + + + LEG
Sbjct: 693 ---WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Score = 50.4 bits (119), Expect = 1e-05
Identities = 39/139 (28%), Positives = 63/139 (45%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
N+ A ++ LH AA G +++ LL+ A + + +G PLH A + V
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
LL A V+A + G P HLAA G+ + ++L++ + + + TPL LA +
Sbjct: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRK 737
Query: 161 LKVAQLLLNSHLCVALLEG 179
+ L VA L G
Sbjct: 738 QGIMSFLEGKEPSVATLGG 756
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 115 bits (287), Expect = 3e-25
Identities = 144/500 (28%), Positives = 167/500 (33%), Gaps = 120/500 (24%)
Query: 657 PATAGPRLLTFQGSELSPELQAAMAGGG-PEPLPLPPARSPSQESIGARSRGSGHSQEQP 715
P+TA P+ QG+E+ P + G G P P PLP A I G P
Sbjct: 892 PSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGA------GILPLPPLPGAGIPPP 945
Query: 716 APQPSGGDPSPPQERNLP-EGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA 774
P P P PP LP G PP LPG G PP P P + P PPP
Sbjct: 946 PPLPGAAIPPPPP---LPGAGIPLPP----PLPGAGIPP-----PPPLPGAGIPPPPP-- 991
Query: 775 PWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPG 834
L G PP PP P + P P G
Sbjct: 992 ------LPG-AGIPPPPPLP---GAGIPPPPPLPGAG----------------------- 1018
Query: 835 RSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPG 894
P P P G P G PPPPP + + P P P P
Sbjct: 1019 -------IPPPPPLPGAGIPPPPPLP----GAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1067
Query: 895 PKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAE 954
P GA P L G PP PP P G PG G PP G G+P
Sbjct: 1068 PLPGAGIPPPPPL---PGAGIPPPPPLP-GAGIPPPPPLPG-VGIPPPPPLPGAGIP--- 1119
Query: 955 EGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASA 1014
P P P P PP L + P R P L G+
Sbjct: 1120 ---------PPPPLPGAGIPPPPP-----LPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165
Query: 1015 TPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESS 1074
P P A +P P PP + P P LP G+P P A PP PP PG G+
Sbjct: 1166 PPLPGAGIPPP-----PPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGI--- 1217
Query: 1075 AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPR-- 1132
P APA L PG G P P+ L SGP L P++G +P P+
Sbjct: 1218 -----------PPAPAPPLPPPGTGIPPPPL------LPVSGPPLLPQVGSSTLPTPQVC 1260
Query: 1133 -----PESTGTVGPGQAQQR 1147
P +G G G Q +
Sbjct: 1261 GFLPPPLPSGLFGLGMNQDK 1280
Score = 92.0 bits (227), Expect = 3e-18
Identities = 129/471 (27%), Positives = 154/471 (32%), Gaps = 64/471 (13%)
Query: 714 QPAPQPSGGDPSPPQERNLPEGTERPP--------KLCSSLPGQGPPPYVFMY---PQGS 762
Q +P GG + P LP PP K CS + P + + Q +
Sbjct: 745 QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
Query: 763 PSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST 822
S P PPP W+ AG PP S + P
Sbjct: 805 QSISQPPPPPSLLWS----AGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPP 860
Query: 823 LGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFA------LRARRKGPPPPPPKRL 876
L + + PG L P P P P S A L+ PPPPPP
Sbjct: 861 LPCTESSSSMPG---LGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917
Query: 877 SSVSGPSPEP-------PPLDES----PGPKEGATGPRRRTLSEPAGPSEPPGP-----P 920
+ + P P P PPL + P P GA P L P PP P P
Sbjct: 918 AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977
Query: 921 APAGPASDTEEEEPGP-EGTPPSRGSSGEGLP----FAEEGNLTIKQRPKPAGPPPRETP 975
P P + P P G PP G G+P G P PPP P
Sbjct: 978 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037
Query: 976 ---VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA--PLPSPTPGES 1030
+PP L + P P L G+ P P A P P P PG
Sbjct: 1038 GAGIPPPPP--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
Query: 1031 -PPASSLPQ---PEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1086
PP LP P P LP G+P P A PP PP PG G+ G PP
Sbjct: 1096 IPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
Query: 1087 AAPAALL----KVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRP 1133
P A + +PGAG P P + P P +G P PPP P
Sbjct: 1156 PLPGAGIPPPPPLPGAGIPPPP---PLPGVGIPPPPPLPGVG-IPPPPPLP 1202
Score = 42.7 bits (99), Expect = 0.002
Identities = 88/348 (25%), Positives = 120/348 (34%), Gaps = 55/348 (15%)
Query: 782 AGPPATPPDPPRPKRRSH-SLSR--PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSAL 838
A PA PP P+ + L R GP+ G GEA G T + + L+ P A
Sbjct: 229 AEEPAAPPTAVSPQPGAFLGLDRFLLGPSGG--AGEAPGSP-DTEQALSALSDLPESLAA 285
Query: 839 VRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEG 898
P P+P G P S++ +L A + P SS + P PE P +E+ G
Sbjct: 286 EPREPQQPPSPG-GLPVSEAPSLPAAQPAAKDSP----SSTAFPFPEAGPGEEAAGAPVR 340
Query: 899 ATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNL 958
G E A P G P A + E+ P G P + G P A
Sbjct: 341 GAGDTDEEGEEDAFEDAPRGSPGEEW-APEVGEDAPQRLGEEPEEEAQGPDAPAAAS--- 396
Query: 959 TIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGP 1018
P P P + +C + PL T + + T
Sbjct: 397 ------LPGSPAPSQ---------------------RCFKPYPLITPCY---IKTTTRQL 426
Query: 1019 AAP--LPSPTPGESPPASSLPQPEPSSLPAQGVPTPLA--PSPAMQPPVPPCPGPGLESS 1074
++P PS +P +SP P+P S +G T LA +PA + GL S
Sbjct: 427 SSPNHSPSQSPNQSPRIKRRPEPSLS----RGSRTALASVAAPAKKHRADGGLAAGLSRS 482
Query: 1075 A--ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLA 1120
A T A LL+ A + VS A A P A
Sbjct: 483 ADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAA 530
Score = 32.3 bits (72), Expect = 2.8
Identities = 61/252 (24%), Positives = 73/252 (28%), Gaps = 35/252 (13%)
Query: 671 ELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSR----GSGHSQEQPAPQPSGGDPSP 726
+L + Q G EP P A SP + R SG + E P SP
Sbjct: 216 QLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPG--------SP 267
Query: 727 PQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPA 786
E+ L ++ P L + PP P G P S AP P A PA
Sbjct: 268 DTEQALSALSDLPESLAAEPREPQQPPS----PGGLPVSEAPSLP----------AAQPA 313
Query: 787 TPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT 846
P S + P P G E A PV G R SP
Sbjct: 314 AKDSP-------SSTAFPFPEAGPGEEAAGAPVRGA-GDTDEEGEEDAFEDAPRGSPGEE 365
Query: 847 PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRT 906
P G Q + P P S P+P P R
Sbjct: 366 WAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQ 425
Query: 907 LSEP-AGPSEPP 917
LS P PS+ P
Sbjct: 426 LSSPNHSPSQSP 437
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 114 bits (284), Expect = 7e-25
Identities = 97/292 (33%), Positives = 130/292 (44%), Gaps = 61/292 (20%)
Query: 26 VKATKTKLLGSTKRL----NVNYQDADG--FSALHHAALGGSLELIALLLEAQATVDIKD 79
++A+K L + K+L NVN +D +G + LH AA + ++ LL A V KD
Sbjct: 655 LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD 714
Query: 80 SNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQS 139
G+ PLH A G E LL+R A+VN A L PLH AA G YE+ ++LL+H +
Sbjct: 715 KGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGA 774
Query: 140 NPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAK-------DPCDP----- 187
+P N+ TPLDL E G + LL ALL+ K C P
Sbjct: 775 DPTKKNRDGNTPLDLVKE-GDTDIQDLLRGD---AALLDAAKKGCLARVQKLCTPENINC 830
Query: 188 -----NYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-------------------- 222
+TPLHLAA + EV LL G ++N Q K G
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890
Query: 223 --------------TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
T LHEAA G+T++ LLL G D ++N QT LD+
Sbjct: 891 KYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942
Score = 107 bits (267), Expect = 7e-23
Identities = 98/326 (30%), Positives = 143/326 (43%), Gaps = 60/326 (18%)
Query: 10 AVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSA--LHHAALGGSLELIAL 67
AV G+ + L A + KL+ LNVN +DG + LH AA + ++ L
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQL 387
Query: 68 LLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGH 127
LL+ A V KD G+ PLH A G E LLL+ A VNA L PLH AA
Sbjct: 388 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 447
Query: 128 YEVSEMLLQHQSNPCLVNKAKKTPLDLA------------------------CEFGRLK- 162
EV +LL H ++P LVN K+ +D+A + ++K
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKK 507
Query: 163 -VAQLLLN----------SHLCVALLEGEAKDPCD-------------PNYTTPLHLAAK 198
+A ++N H VA L + K + ++ TPLH+AA+
Sbjct: 508 TLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAE 567
Query: 199 NGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA 257
H +V+ L + G ++N G TALH AAL G + RLLL G D +I + TA
Sbjct: 568 RAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTA 627
Query: 258 LDIVNQFTTSQASREIKQLLREASGI 283
+ N+ ++Q+L E++ I
Sbjct: 628 AQMGNE--------AVQQILSESTPI 645
Score = 105 bits (263), Expect = 2e-22
Identities = 89/273 (32%), Positives = 124/273 (45%), Gaps = 30/273 (10%)
Query: 2 GREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADG--FSALHHAALG 59
G ++L+ A +NGDV+ V++LV NVN +D G S LH AA
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDAA--------------NVNAKDMAGRKSSPLHFAAGF 226
Query: 60 GSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPL 119
G +++ LL+ A V +D G+ PLH A G E V LLL A NA PL
Sbjct: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286
Query: 120 HLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEG 179
H AA G +V +LLQH ++P + N K+ LDLA + + L A G
Sbjct: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSG 346
Query: 180 EAK-------------DPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TAL 225
+ D +TPLHLAA +++ LL+ G +++ + K G L
Sbjct: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
Query: 226 HEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
H A YG EV LLL+ G VN + + T L
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPL 439
Score = 84.3 bits (207), Expect = 6e-16
Identities = 85/298 (28%), Positives = 122/298 (40%), Gaps = 44/298 (14%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
K NVN ++ D + LH AA +++ +L + A ++ D+ G LH AA G L+
Sbjct: 547 KGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT 606
Query: 98 VRLLLRASAAVNAASLDGQIPLHL--------------------------AAQYGHYEVS 131
RLLL + + SL G + A++ G E
Sbjct: 607 CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETV 666
Query: 132 EMLLQHQSNPCL-VNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYT 190
+ L Q+ C + TPL A + R+ V + LL+ G D
Sbjct: 667 KQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH--------HGADVHAKDKGGL 718
Query: 191 TPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNI 249
PLH A GH EV L+R G +N T LHEAA GK E+ +LLL+ G D
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 778
Query: 250 RNTYNQTALDIVNQFTTSQASREIKQLLREASGIL---KVRALKDFWNLHDPTALNVR 304
+N T LD+V + T +I+ LLR + +L K L L P +N R
Sbjct: 779 KNRDGNTPLDLVKEGDT-----DIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR 831
Score = 82.0 bits (201), Expect = 3e-15
Identities = 58/155 (37%), Positives = 85/155 (54%), Gaps = 11/155 (7%)
Query: 11 VKNGDVTGVQKLV----AKVKATKTKLLGSTKRL----NVNYQDADGFSA--LHHAALGG 60
VK GD T +Q L+ A + A K L ++L N+N +D G ++ LH AA
Sbjct: 790 VKEGD-TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYN 848
Query: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
+LE+ LLE A V+ +D G+ PLH AA G ++ LL++ + VNA PLH
Sbjct: 849 NLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH 908
Query: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
AAQ G ++ +LL H ++P + N+ +TPLDLA
Sbjct: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 67.8 bits (164), Expect = 6e-11
Identities = 48/129 (37%), Positives = 63/129 (48%), Gaps = 9/129 (6%)
Query: 148 KKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQ 207
K +PL A FGR V + LL G D PLH A GH EV+
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQM--------GANVHARDDGGLIPLHNACSFGHAEVVSL 267
Query: 208 LLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
LL G + N R T LHEAA+ GK +V +LL+ G D NIRNT ++ALD+ +
Sbjct: 268 LLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 267 SQASREIKQ 275
+ + E K+
Sbjct: 328 AVLTGEYKK 336
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/94 (29%), Positives = 55/94 (58%), Gaps = 4/94 (4%)
Query: 562 DLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAE 621
++ ++L +LGL ++ + + + ++ ++AD+ EEL+EIG+N GH+ KL+ GV+RL
Sbjct: 1030 NISQFLKSLGL-EHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLG 1088
Query: 622 LRRG---LLQGEALSEGGRRLAKGPELMAIEGLE 652
++G L +++G L PE + +E
Sbjct: 1089 GQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVE 1122
Score = 38.5 bits (88), Expect = 0.039
Identities = 45/172 (26%), Positives = 63/172 (36%), Gaps = 17/172 (9%)
Query: 910 PAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGN-LTIKQRPKPAG 968
P + PP PP P P P TP S +SG PFA + L + +
Sbjct: 22 PGASAPPPPPPPPLSPGL-------APGTTPASPTASGLA-PFASPRHGLALPEGDGSRD 73
Query: 969 PPPR-ETPVPPGLDFNLTESDTVKRRPKCR-EREPLQTALLAFGVASATPGPAAPLPSPT 1026
PP R +P P + + T+ C P+ A+ A P PA + +
Sbjct: 74 PPDRPRSPDPVDGTSCCSTTSTI-----CTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNS 128
Query: 1027 PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPV-PPCPGPGLESSAAS 1077
P S +S PSS + +P A + P+ P GPG A S
Sbjct: 129 PSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS 180
Score = 38.1 bits (87), Expect = 0.051
Identities = 41/147 (27%), Positives = 50/147 (34%), Gaps = 14/147 (9%)
Query: 1012 ASATPGPAAPLPSP--TPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGP 1069
ASA P P P SP PG +P + + P + P G+ P P P P P
Sbjct: 24 ASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDP 83
Query: 1070 GLESSAASRWNGETEPPAAPA--ALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRP 1127
+S S + AAP A+ AG AP P S P
Sbjct: 84 VDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSP 143
Query: 1128 VPP-----PRPE-----STGTVGPGQA 1144
P PE ST +GPG A
Sbjct: 144 SSPGSSLAESPEAAGVSSTAPLGPGAA 170
Score = 37.4 bits (85), Expect = 0.087
Identities = 46/208 (22%), Positives = 66/208 (31%), Gaps = 28/208 (13%)
Query: 760 QGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPV 819
Q P+ A PPP P S P TP P + R G + +G + P
Sbjct: 17 QLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPP- 75
Query: 820 GSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSV 879
RP +P P GT + + P P SS
Sbjct: 76 -----------DRPR-----------SPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSA 113
Query: 880 SGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP--- 936
+G +P P + P ++ P + S P+ P A S T PG
Sbjct: 114 AGVAPNPAGSGSNNSP-SSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGP 172
Query: 937 -EGTPPSRGSSGEGLPFAEEGNLTIKQR 963
G P G+ E L G+++ +R
Sbjct: 173 GTGVPAVSGALRELLEACRNGDVSRVKR 200
Score = 35.4 bits (80), Expect = 0.33
Identities = 54/203 (26%), Positives = 67/203 (33%), Gaps = 53/203 (26%)
Query: 710 HSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSL-PGQGPPPYVFMYPQGSPSSPAP 768
H Q+Q P P P PP PP L L PG P P S +P
Sbjct: 13 HHQQQLQPAPGASAPPPPP----------PPPLSPGLAPGTTPAS-----PTASGLAPFA 57
Query: 769 GPPPGAPWAFSYLAGPPA----TPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLG 824
P G LA P PPD PR P P +G + ST
Sbjct: 58 SPRHG-------LALPEGDGSRDPPDRPR---------SPDPVDGTS-------CCSTTS 94
Query: 825 SYATLTRRPGRSALVRTSPS-VTPTPA----RGTPRSQSFALRARRKGPPPPPPKRLSSV 879
+ T+ P A+ +S + V P PA +P S S + P P S
Sbjct: 95 TICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSP-----GSS 149
Query: 880 SGPSPEPPPLDESPGPKEGATGP 902
SPE + + GA GP
Sbjct: 150 LAESPEAAGVSSTAPLGPGAAGP 172
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 110 bits (275), Expect = 8e-24
Identities = 77/280 (27%), Positives = 132/280 (47%), Gaps = 37/280 (13%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
+I A+ + +V G+Q L LGS +VN + G L AA G+++++
Sbjct: 348 IIHAINDDNVPGLQHL-----------LGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYG 126
LL++ + +D++D G +++AA G ++ ++ L ++ G++ LH+AA+YG
Sbjct: 397 LLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYG 456
Query: 127 HYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDP-- 184
H +V+++L SNP + +K ++TPL A G VA+ L + V + E + P
Sbjct: 457 HADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLL 516
Query: 185 -----------------------CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKT 221
CD + LHLA + EVI+ LL G ++ Q +
Sbjct: 517 TASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH 576
Query: 222 G-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G T LH A G +V L E +++I N Y +T L +
Sbjct: 577 GNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Score = 95.9 bits (237), Expect = 2e-19
Identities = 74/261 (28%), Positives = 121/261 (46%), Gaps = 9/261 (3%)
Query: 36 STKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRL 95
S + ++ +D G ALH AA G ++ LL + +I+D PLH AAW G
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491
Query: 96 EPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
+ L A VN + +G+ PL A+ G++++ E L +H ++ +K L LA
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 156 CEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEI 215
+++V + LL+ +G D D + TPLH+A K+G+ ++ L A +
Sbjct: 552 VRRCQMEVIKTLLS--------QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNL 603
Query: 216 NRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIK 274
+ K G T LH AA G +VVR L G V T +TA D+ + +
Sbjct: 604 DISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLA 663
Query: 275 QLLREASGILKVRALKDFWNL 295
+L ++ L ++ L+ NL
Sbjct: 664 RLRKDTHRGLFIQQLRPTQNL 684
Score = 60.5 bits (145), Expect = 1e-08
Identities = 56/207 (27%), Positives = 89/207 (42%), Gaps = 9/207 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
NVN ++ +G + L A+ G +++ L E A ++ D +G LH A + ++E ++
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
LL V+ G PLH+A + G+ + L + N + NK +TPL LA G
Sbjct: 563 LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGI 622
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCD-------PNYTTPLHLAAKNGHREVIRQLLRAGI 213
L V + L V L + K D + L K+ HR + Q LR
Sbjct: 623 LDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQ 682
Query: 214 EINRQTKTGTALHEAALYGKTEVVRLL 240
+ + K H + GKT +V L
Sbjct: 683 NLQPRIKLKLFGHSGS--GKTTLVESL 707
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 110 bits (274), Expect = 1e-23
Identities = 147/527 (27%), Positives = 185/527 (35%), Gaps = 97/527 (18%)
Query: 677 QAAMAGGGPEPLPLP---PARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLP 733
+A GG P P P RS S SR + + AP P P
Sbjct: 61 RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120
Query: 734 EGTERPPKL--------CSSLPGQGPP---PYVFMYPQGS---PSSPAPGPPPGAPWAFS 779
GT RP L +G P G+ S P PG P A S
Sbjct: 121 SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180
Query: 780 YLAG---------PPATPPDPPRPKRRS------HSLSRPGPT---EGDAEGEAEGPVGS 821
AG P A P P R+S HS + P P A G + P
Sbjct: 181 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240
Query: 822 TLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKG-----PPP--PPPK 874
+L S AT P RS PS ARGTPR+ + + + KG PP PP K
Sbjct: 241 SLSSSATPLSSPARSG-----PS-----ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290
Query: 875 RLSSVSGP-------SPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS 927
+ GP +P P +S P P +L+ P PP+P+ P S
Sbjct: 291 DAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPS 350
Query: 928 DTEEEEPGPEGTPPSRGSSGEGLP-------FAEEGNLTIKQRPKPAGPP-----PRETP 975
+ P P TPPS+ ++ G P F L+ P P PP P + P
Sbjct: 351 --LQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP 408
Query: 976 VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASS 1035
P L+ T P + L LL A +P P+ P+ +P SPPAS
Sbjct: 409 PSPPASPPLSPLAT----PSPQAPNALAVHLLQ---APFSPPPSPPVQAPF---SPPAS- 457
Query: 1036 LPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESS----------AASRWNGETEP 1085
P PS+ P P LA P PP PP P S+ AA P
Sbjct: 458 -PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516
Query: 1086 PAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPR 1132
P AP A L P P P + Q FS P + + P PPP+
Sbjct: 517 PQAPPA-LATPPLQALPSPPASFPGQAPFS-PSASLPMSPLATPPPQ 561
Score = 94.4 bits (233), Expect = 6e-19
Identities = 142/547 (25%), Positives = 187/547 (34%), Gaps = 103/547 (18%)
Query: 687 PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPE-GTERPPKLCSS 745
P P PP + +GA +G +P + +GG + P G R S
Sbjct: 33 PRPPPPVTPAALRVLGA----AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88
Query: 746 LPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPG 805
P PP A G AP A + GP ++P R+ +RPG
Sbjct: 89 NPASRPP--------------ASGRGERAPPAKNTSPGPVSSPG-------RASGTTRPG 127
Query: 806 PTEGDAEGEAEGPVGSTLGSYATLTR-----RPGRSALVRTSPSVTPTPARGTPRSQSFA 860
P G G + + T+ R P RSAL + T P GTP S + A
Sbjct: 128 PL---------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMA 177
Query: 861 LRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPP 920
R+R G P+ PS P P E P + T PA P
Sbjct: 178 RRSRAAGTEVGLPR-----PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232
Query: 921 APAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAG---------PPP 971
PAS + P +P G S G P A +PKP G PP
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAP----AHPSQPKPKGLQALRPPQVTPP 288
Query: 972 RETPVPPGLDFNLTESDTVKRRPKCREREP----------LQTALLAFGVASATPGPAAP 1021
R+ P + + T + + P T LA + A P P+AP
Sbjct: 289 RKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP 348
Query: 1022 -----LPSP--TPGE-------------------SPPASSLPQPEPSSLPAQGVPTPLA- 1054
LPSP TP SPP S L P P + PA +P A
Sbjct: 349 PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP 408
Query: 1055 PSPAMQPPVPPCPGPGLESS---AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQ 1111
PSP PP+ P P ++ A PP +P ++ P + A PVS + T
Sbjct: 409 PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP--VQAPFSPPASPPVSPSATP 466
Query: 1112 LAFSGPKL-APRLGPRPVPPPRPE-STGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTK 1169
+ + P L AP L P PP P S P QA L LA A ++ T
Sbjct: 467 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 526
Query: 1170 EQEGTPS 1176
+ PS
Sbjct: 527 PLQALPS 533
Score = 91.3 bits (225), Expect = 5e-18
Identities = 139/509 (27%), Positives = 177/509 (34%), Gaps = 103/509 (20%)
Query: 686 EPLPLPPARSPSQE--SIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLC 743
+ LP PPA PSQ S+G+ + + HS P+P S PPQ P PP
Sbjct: 352 QTLPSPPATPPSQATTSLGSPTLQATHSF-LPSPPLSPLATPPPQA---PPALALPPLQA 407
Query: 744 SSLPGQGPP--PYVFMYPQG----------SPSSPAPGPPPGAPWAFSYLAGPPATPPDP 791
P PP P PQ +P SP P PP AP FS A PP +P
Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP--FSPPASPPVSPSAT 465
Query: 792 PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPAR 851
P P + SL+ P P + A P+ SPS TP P
Sbjct: 466 P-PSQAPPSLAAP-PLQVPPSPPASPPM----------------------SPSATPPPQA 501
Query: 852 GTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATG--PRRRTLSE 909
P + A+ PPP P L++ PPL P P G P + S
Sbjct: 502 PPPLAAPPLQLAK---PPPQAPPALAT--------PPLQALPSPPASFPGQAPFSPSASL 550
Query: 910 PAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEG----NLTIKQRPK 965
P P P P AP A+ + P P +P + P + LT+ P
Sbjct: 551 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610
Query: 966 PAGPPPRE-TPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPS 1024
P PP R + G D S + R G S G AA P
Sbjct: 611 PPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR------------GYDSGPEGGAAASP- 657
Query: 1025 PTPGESPPASSLPQPEPSSLPAQGVPTPLA--PSPAMQPPVPPCPGPGLESSAASRWNGE 1082
PP + L P++ ++G PLA +P P PP GPG + + E
Sbjct: 658 ------PPDAELAACHPAAW-SRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY--E 708
Query: 1083 TEPP----AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGT 1138
TE P AP AL P GT+ + A S RLG P+
Sbjct: 709 TEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPL---------- 758
Query: 1139 VGPGQAQQRLEQTSSSLAAALRAAEKSIG 1167
G Q + Q S L AAE + G
Sbjct: 759 ---GALQASVVQHLLSRTLLLAAAEGAAG 784
Score = 68.9 bits (167), Expect = 3e-11
Identities = 104/387 (26%), Positives = 131/387 (33%), Gaps = 88/387 (22%)
Query: 674 PELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDP-----SPPQ 728
P LQA + P PL P +PS ++ A + + P P P P SPP
Sbjct: 403 PPLQAPPSP--PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460
Query: 729 ERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSS--PAPGPPPGAPWAFSYLAGPPA 786
+ ++ PP L + P PP P SPS+ P PPP A PP
Sbjct: 461 SPSATPPSQAPPSLAA--PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518
Query: 787 TPP---DPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP 843
PP PP S S PG + P SA + SP
Sbjct: 519 APPALATPPLQALPSPPASFPG----------QAPFSP--------------SASLPMSP 554
Query: 844 SVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPR 903
TP P + P L A PP PP + P+ + P +PGP +GPR
Sbjct: 555 LATP-PPQAPP-----VLAAPLLQVPPSPP------ASPTLQAPRRPPTPGPDTSVSGPR 602
Query: 904 RRTLSEPAGPSEPPGPPAP--AGP--------ASDTEEE----EPGPEG----TPPSRGS 945
P P P P+ +GP A+ T EE + GPEG +PP
Sbjct: 603 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 662
Query: 946 SGEGLPFAEEGNLT--IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQ 1003
P A + R P P P PG + L
Sbjct: 663 LAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG------------------SADGLC 704
Query: 1004 TALLAFGVASATPGPAAPLPSPTPGES 1030
T G SATP P A P P+PG S
Sbjct: 705 TIYETEGPESATPAPGALDPGPSPGTS 731
Score = 41.6 bits (96), Expect = 0.005
Identities = 58/245 (23%), Positives = 85/245 (34%), Gaps = 33/245 (13%)
Query: 964 PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 1023
P+P G P PV P L + V R+P + A + A P +A
Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86
Query: 1024 SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 1062
S P PPAS + P P S P + P PL A +
Sbjct: 87 SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146
Query: 1063 VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1118
P S+ A R +G T +PA + AGT P+P A + GP+
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206
Query: 1119 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1171
+ P P RP + G + A + L +++ L++ R+ + GT
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 265
Query: 1172 EGTPS 1176
PS
Sbjct: 266 PAHPS 270
Score = 37.7 bits (86), Expect = 0.066
Identities = 47/189 (24%), Positives = 68/189 (35%), Gaps = 29/189 (15%)
Query: 998 EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 1057
+R+ + A A+ PG P P +P PP + P++L G + P
Sbjct: 4 KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57
Query: 1058 ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1107
A P P GP + +SR N + PPA+ P T+P PVS
Sbjct: 58 LAERAGGIGGATIPESAPRAGPTRSAGTSSR-NPASRPPASGRGERAPPAKNTSPGPVSS 116
Query: 1108 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1167
+ P GP R + TV G+A T + +AL A +
Sbjct: 117 PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 164
Query: 1168 TKEQEGTPS 1176
+ GTPS
Sbjct: 165 SGPTPGTPS 173
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 108 bits (270), Expect = 3e-23
Identities = 82/255 (32%), Positives = 129/255 (50%), Gaps = 22/255 (8%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L+ A+ + DV V+ L+++ + N+N D + + LH AA G + ++
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKE-------------NINVLDQERRTPLHAAAYVGDVPILQ 58
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYG 126
LLL + A V+ KD+ + PLH AA + + LLL SA VNA Q PLH+AA
Sbjct: 59 LLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118
Query: 127 HYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCD 186
+ +E L S+ + +++ ++ L A G L+ LLLN +G + + CD
Sbjct: 119 ATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN--------KGASLNVCD 170
Query: 187 PNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLLEGGV 245
PLH AA GH EV++ L+ G ++ + + G LH AA G+ EVV+ LL G
Sbjct: 171 KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA 230
Query: 246 DVNIRNTYNQTALDI 260
+++ N + TAL I
Sbjct: 231 EIDEPNAFGNTALHI 245
Score = 106 bits (264), Expect = 2e-22
Identities = 81/266 (30%), Positives = 131/266 (49%), Gaps = 17/266 (6%)
Query: 8 ILAVKNGDVTGVQKL-------VAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG 60
+L + DV KL A +ATK + ++N D G SALHHA G
Sbjct: 92 LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSG 151
Query: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
LE + LLL A++++ D +PLH+AA+ G LE ++LL+ A + G LH
Sbjct: 152 HLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLH 211
Query: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE 180
AA G EV + LL+ + N T L +AC G+ VA L+N+
Sbjct: 212 TAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA-------GAN 264
Query: 181 AKDPCDPNYTTPLHLAAKNGHREVIRQLL-RAGIEINRQTKTG-TALHEAALYGKTEVVR 238
P D + TPLH+AA + + + +LL G ++N Q+K G + LH AA++G+ +
Sbjct: 265 VNQPNDKGF-TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 239 LLLEGGVDVNIRNTYNQTALDIVNQF 264
+L++ G +++ + + T L + ++
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARY 349
Score = 88.6 bits (218), Expect = 3e-17
Identities = 70/220 (31%), Positives = 105/220 (47%), Gaps = 12/220 (5%)
Query: 41 NVNYQDADGFSALHHAALGGSLEL-IALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
NVN + GF+ LH AA+ + L + LL+ A V+ + G PLH AA GR +
Sbjct: 264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L++ + ++ A G PLH+AA+YGH + L+ + ++ PL LA FG
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383
Query: 160 RLKVAQLLLNS---HLCVALLEGEAKDPCDPNYTTP-------LHLAAKNGHREVIRQLL 209
+ LL+S + V+ L E + TP LH AA G+ E + LL
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 210 RAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVN 248
+G ++ R+ K G T LH AA G + L+ G VN
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483
Score = 87.0 bits (214), Expect = 1e-16
Identities = 74/240 (30%), Positives = 105/240 (43%), Gaps = 37/240 (15%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
++N D G + LH AA GG++E + LLL + A + +D G PLHYAA G +
Sbjct: 415 DINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVT 474
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVS----------------------------E 132
L+ A A VN A G PLH AA Y + E
Sbjct: 475 LVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLE 534
Query: 133 MLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLN-SHLCVALLEGEAKDPCDPNYTT 191
LL + ++P L ++ T + A +G + +LLL S C+ +E +
Sbjct: 535 FLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP-------VS 587
Query: 192 PLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIR 250
PLHLAA NGH E ++ L + ++ R K TAL A G TE V +L G I+
Sbjct: 588 PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIK 647
Score = 77.4 bits (189), Expect = 8e-14
Identities = 75/234 (32%), Positives = 107/234 (45%), Gaps = 17/234 (7%)
Query: 33 LLGSTKRLNV-NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAW 91
L+ S +R ++ + DA G + L A + G ++ + LLLE +T D D G LH A
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
Query: 92 QGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQH--QSNP--CLVNKA 147
G + + LL A V G+ P+HLA+ GH V LLQ ++P V+ +
Sbjct: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790
Query: 148 KKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQ 207
+P+ A G +LLL H + LEG N TPLH A N
Sbjct: 791 GYSPMHWASYTGHEDCLELLL-EHSPFSYLEG--------NPFTPLHCAVINNQDSTTEM 841
Query: 208 LLRA-GIEI--NRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
LL A G +I +R K T LH AA +R+LL+ +VN + +TAL
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Score = 74.3 bits (181), Expect = 6e-13
Identities = 65/209 (31%), Positives = 89/209 (42%), Gaps = 16/209 (7%)
Query: 46 DADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRAS 105
D G+S +H A+ G + + LLLE + + N PLH A + +LL A
Sbjct: 788 DYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGAL 846
Query: 106 AA--VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKV 163
A VN+ G+ PLH AA + MLLQHQ+ + +T L A E G+
Sbjct: 847 GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
Query: 164 AQLLLNSHLCVALLEGEAK-DPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
+ LL G+A D N T LHLA GH + +L ++ T
Sbjct: 907 VEFLL--------YRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATN 958
Query: 223 TA----LHEAALYGKTEVVRLLLEGGVDV 247
+A LH AA G VV+ LL G V
Sbjct: 959 SALQMPLHIAARNGLASVVQALLSHGATV 987
Score = 73.2 bits (178), Expect = 1e-12
Identities = 53/176 (30%), Positives = 86/176 (48%), Gaps = 8/176 (4%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQAT--VDIKDSNGMRPLHYAAWQGRLEPVRL 100
+Y + + F+ LH A + +LL A V+ +D+ G PLH AA+ + +R+
Sbjct: 817 SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQH-QSNPCLVNKAKKTPLDLACEFG 159
LL+ A VNA G+ L AA+ G E LL +++ ++++ K T L LAC G
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEI 215
K A ++L + L+ + PLH+AA+NG V++ LL G +
Sbjct: 937 HEKCALMILAETQDLGLINAT-----NSALQMPLHIAARNGLASVVQALLSHGATV 987
Score = 68.2 bits (165), Expect = 5e-11
Identities = 54/168 (32%), Positives = 77/168 (45%), Gaps = 7/168 (4%)
Query: 28 ATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLH 87
+T LLG+ VN +DA G + LH AA ++ + +LL+ QA V+ D G L
Sbjct: 837 STTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALM 896
Query: 88 YAAWQGRLEPVRLLL-RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV-- 144
AA G+ V LL R A + + LHLA GH + + M+L + L+
Sbjct: 897 TAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINA 956
Query: 145 -NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDP---CDPN 188
N A + PL +A G V Q LL+ V ++ E P C PN
Sbjct: 957 TNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN 1004
Score = 59.3 bits (142), Expect = 2e-08
Identities = 51/166 (30%), Positives = 71/166 (42%), Gaps = 9/166 (5%)
Query: 85 PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 144
PL A + +E VR LL +N + + PLH AA G + ++LL +N
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 145 NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 204
+ TPL A KV LLL V + D + TPLH+AA N +
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADV--------NARDKLWQTPLHVAAANRATKC 122
Query: 205 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNI 249
L +N ++G +ALH A G E V LLL G +N+
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 9/148 (6%)
Query: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH 171
S+ Q PL A E LL + N ++++ ++TPL A G + + QLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL---- 60
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKT-GTALHEAAL 230
L+ G + D + TPLH AA + + +V+ LL ++N + K T LH AA
Sbjct: 61 ----LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAA 116
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
T+ L +N+ + ++AL
Sbjct: 117 NRATKCAEALAPLLSSLNVADRSGRSAL 144
Score = 45.4 bits (106), Expect = 3e-04
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 186 DPNYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGG 244
D TPLH AA G +++ LL +G +N + T T LH AA +V+ LLL
Sbjct: 38 DQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHS 97
Query: 245 VDVNIRNTYNQTALDIVNQFTTSQASREIKQLL 277
DVN R+ QT L + ++ + + LL
Sbjct: 98 ADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 108 bits (269), Expect = 4e-23
Identities = 138/507 (27%), Positives = 176/507 (34%), Gaps = 79/507 (15%)
Query: 673 SPELQAAMAGGGPEPLP--LPPARSPSQESIG-----ARSRGSGHSQEQPA------PQP 719
SP LQA ++ PL L PA SP + A S + HS + P P
Sbjct: 454 SPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLE 513
Query: 720 SGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPY-VFMYPQGSPSSPAPGPPPGAPWAF 778
+ +PP + P PP +LP PPP P +P P P P
Sbjct: 514 TQSSLAPPSLQTPPASLTTPP--LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP--- 568
Query: 779 SYLAGPPA--TPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRS 836
L PP+ T P P P S++ P P + P L P
Sbjct: 569 --LQAPPSPLTTPPPETPS----SIATPPP---------QAPPALASPPLQGLPSPP--- 610
Query: 837 ALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPP--------P 888
SP TP P AL + P PP LS ++ PSP+ P
Sbjct: 611 ----LSPLATPPPQA----PPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 662
Query: 889 LDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 948
SP P P S P PS P AP A+ + P P +PP S+
Sbjct: 663 APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 722
Query: 949 GLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRR-PKCREREPLQTALL 1007
Q P P PP + P P ++ S T R P PLQ
Sbjct: 723 P-----------PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPS 771
Query: 1008 AFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCP 1067
+P P +P +PP +LP P P+S P Q +P A P PP
Sbjct: 772 PPASLPMSPLAKPPPQAPPALATPPLQALPSP-PASFPGQAPFSPSASLPMSPLATPPPQ 830
Query: 1068 GPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRP 1127
P + AA PPA+P L+ P P P + SGP+L L P P
Sbjct: 831 APPV--LAAPLLQVPPSPPASPT--LQAPRRPPTPGP------DTSVSGPRLTLALAPGP 880
Query: 1128 VPPP-RPESTGTVGPGQAQQRLEQTSS 1153
PPP R S+ GP A TS+
Sbjct: 881 PPPPSRSPSSTLSGPDLAGHSSSATST 907
Score = 95.9 bits (237), Expect = 2e-19
Identities = 150/566 (26%), Positives = 195/566 (34%), Gaps = 87/566 (15%)
Query: 665 LTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDP 724
L Q S P LQ A PL P+ +P + + H + P P P
Sbjct: 512 LETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQ- 570
Query: 725 SPPQERNLPEGTERPPKLCSSL---PGQGPPPYVFMYPQGSPS---SPAPGPPPGAP--W 776
+PP P PP+ SS+ P Q PP QG PS SP PPP AP
Sbjct: 571 APPSPLTTP-----PPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL 625
Query: 777 AFSYLAGPPATPPDPPRPKRRSHSLSRPGPT-----EGDAEGEAEGPVGSTLGSYATLTR 831
A L PP+ P PP + S P + PV + A+
Sbjct: 626 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 685
Query: 832 RPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDE 891
P + + PS+ P + P + + PPP P L++ P PP
Sbjct: 686 SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA-- 743
Query: 892 SPGPKEGATGPRRRTLSEPAGPSE-PPGPPA--PAGPASDTEEEEPGPEGTPP-----SR 943
SP AT P R A P + PP PPA P P + + P TPP S
Sbjct: 744 SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803
Query: 944 GSSGEG-LPFAEEGNLTIKQ--RPKPAGPPPRETP---VPPGLDFNLTESDTVKRRPKCR 997
+S G PF+ +L + P P PP P VPP + T +R P
Sbjct: 804 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT-LQAPRRPPTPG 862
Query: 998 EREPLQTALLAFGVASATPGPAAPLPSPT------PGESPPASSLPQ------------- 1038
+ L +A P P + PS T G S A+S P+
Sbjct: 863 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922
Query: 1039 ----PEPSSLPA-------QGVPTPLA--PSPAMQPPVPPCPGPGLESSAASRWNGETEP 1085
P + L A +G PLA +P P PP GPG + + ETE
Sbjct: 923 AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY--ETEG 980
Query: 1086 P----AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGP 1141
P AP AL P GT+ + A S RLG P+
Sbjct: 981 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPL------------- 1027
Query: 1142 GQAQQRLEQTSSSLAAALRAAEKSIG 1167
G Q + Q S L AAE + G
Sbjct: 1028 GALQASVVQHLLSRTLLLAAAEGAAG 1053
Score = 90.9 bits (224), Expect = 7e-18
Identities = 158/606 (26%), Positives = 204/606 (33%), Gaps = 157/606 (25%)
Query: 657 PATAGPRLLTFQGSELSPE------LQAAMAGGGPEPLPLPPARSPSQE----SIGARSR 706
P T GPR SE S + AGGG L P +RS S S ARS
Sbjct: 200 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG---LQRPASRSLSSSATPLSSPARSG 256
Query: 707 GSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGP---PPYVFMYPQGSP 763
S + PS P Q P+ T PP+ + P GP P P G+
Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVT--PPRK-DAAPALGPLSSSPLATPSPSGTK 313
Query: 764 SSPAP--------------------------GPPPGAPWAFSYLAGPPATPPD--PPR-- 793
+ P P P P AP + L PPATPP PP
Sbjct: 314 ARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMT 373
Query: 794 --------------PKRRSHSLSRP---------GPTEGDAEGEAEGPVGSTLGSYATLT 830
P + HSL+ P + A P S+ T++
Sbjct: 374 TPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS 433
Query: 831 RRPGRSALVRTS-PSVTP--TPARGTPRS---------------------------QSFA 860
R +++L S P+ TP +P P S Q+ +
Sbjct: 434 PRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS 493
Query: 861 LRARRKGPPP------PPPKRLSSVSGPSPEPPPLDESPGPKEGATG---PRRRTLSEPA 911
A P PP + SS++ PS + PP + P E P +T S P
Sbjct: 494 SLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPL 553
Query: 912 GPSEPPGPPAPA--------GPASDTEEEEPGPEGTPPSRGSSG------EGLPFAEEGN 957
PP PA P + E P TPP + +GLP
Sbjct: 554 TTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSP 613
Query: 958 LTI--KQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASAT 1015
L Q P PP + P P L+ T P + L LL A +
Sbjct: 614 LATPPPQAPPXLALPPLQAPPSPPASPPLSPLAT----PSPQAPNALAVHLLQ---APFS 666
Query: 1016 PGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSA 1075
P P+ P+ +P SPPAS P PS+ P P LA P PP PP P S+
Sbjct: 667 PPPSPPVQAPF---SPPAS--PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA- 720
Query: 1076 ASRWNGETEPPAAPAAL----LKVPGAGTAPKPVSVACTQLAFSGPKLAPRLG--PRPVP 1129
T PP AP L L+VP + A P+S + T P++ P L P VP
Sbjct: 721 -------TPPPQAPPPLAAPPLQVPPSPPASPPMSPSAT----PPPRVPPLLAAPPLQVP 769
Query: 1130 PPRPES 1135
P P S
Sbjct: 770 PSPPAS 775
Score = 89.4 bits (220), Expect = 2e-17
Identities = 143/553 (25%), Positives = 177/553 (32%), Gaps = 117/553 (21%)
Query: 631 ALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPL 690
ALS G RR GP P T P + + A G P P P
Sbjct: 155 ALSAGARRDTSGPT------------PGTPSPAMARRSRA-------AGTEVGLPRPAPS 195
Query: 691 PPARSPSQESIGARSRGSGHSQEQPAP----QPSGGDPSPPQERNLPEGTERPPKLCSSL 746
R P++ + S S HS +P+P +PS G G +RP S
Sbjct: 196 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG-----------GLQRPASRSLS- 243
Query: 747 PGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP-- 804
S ++P P P A G P P P +PK + RP
Sbjct: 244 ---------------SSATPLSSPARSGPSA----RGTPRAPAHPSQPKPKGLQALRPPQ 284
Query: 805 -GPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 863
P DA A GP+ S S L SPS T AR P + A
Sbjct: 285 VTPPRKDA-APALGPLSS--------------SPLATPSPS--GTKARPVPPPDNAATPL 327
Query: 864 RRKGPPPPPPKRLSSVSGPSPEPPP----LDESPGPKEGATGPRRRTLSEPAGPSEPPGP 919
PP PP ++ PSP PP L P P T A PS P
Sbjct: 328 PATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387
Query: 920 P--APAGPASDTEEEEPGPEGTPPSRGSSGEGLPF--AEEGNLTIKQR---------PKP 966
P P S + + P P + ++ G P A LT+ R +P
Sbjct: 388 PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRP 447
Query: 967 AGPPPRETPVPPGLDFNLTESDTVKRRPKCRE-REPLQTALLAFGVASATPGPAAPLPSP 1025
A PP P+ L + P PL L + A+ P APL S
Sbjct: 448 ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSL 507
Query: 1026 TPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPP---------------VPPCPGPG 1070
SSL P + PA PL P++ PP PPCP P
Sbjct: 508 IMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPC 567
Query: 1071 LESSAASRWNG---------ETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLA- 1120
+ S T PP AP AL P G P+S T + P LA
Sbjct: 568 PLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLAL 627
Query: 1121 PRLGPRPVPPPRP 1133
P L P PP P
Sbjct: 628 PPLQAPPSPPASP 640
Score = 88.6 bits (218), Expect = 3e-17
Identities = 126/481 (26%), Positives = 176/481 (36%), Gaps = 83/481 (17%)
Query: 687 PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPE-GTERPPKLCSS 745
P P PP + +GA +G +P + +GG + P G R S
Sbjct: 33 PRPPPPVTPAALRVLGA----AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88
Query: 746 LPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPG 805
P PP A G AP A + GP ++P R+ +RPG
Sbjct: 89 NPASRPP--------------ASGRGERAPPAKNTSPGPVSSPG-------RASGTTRPG 127
Query: 806 PTEGDAEGEAEGPVGSTLGSYATLTR-----RPGRSALVRTSPSVTPTPARGTPRSQSFA 860
P G G + + T+ R P RSAL + T P GTP S + A
Sbjct: 128 PL---------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMA 177
Query: 861 LRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPP 920
R+R G P+ P+P P + GP++ + + +EP+ P+ P
Sbjct: 178 RRSRAAGTEVGLPR-------PAPSARPRPPTEGPRKSVSSASEHSTTEPS-PAARRRPS 229
Query: 921 APAG---PASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 977
A G PAS + P +P G S G P A PA P P P
Sbjct: 230 AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA------------PAHP---SQPKP 274
Query: 978 PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 1037
GL T R+ PL ++ LA TP P+ P P A+ LP
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLA------TPSPSGTKARPVPPPDNAATPLP 328
Query: 1038 QPEPSSLPAQGVPTPLA-PSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL---- 1092
P S P P PLA PSP+ P + P P + + + T P AP +L
Sbjct: 329 ATLPPS-PPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387
Query: 1093 -LKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQT 1151
++VP + T+P + + LA S + LG + S T+ P Q Q L
Sbjct: 388 PIQVPHSLTSPS-LQAPPSPLALSSLQATTSLGSPTL--QATHSFLTMSPRQTQASLTSP 444
Query: 1152 S 1152
S
Sbjct: 445 S 445
Score = 86.3 bits (212), Expect = 2e-16
Identities = 127/512 (24%), Positives = 177/512 (34%), Gaps = 84/512 (16%)
Query: 657 PATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPA 716
PA +GP + +G+ +P + G + L P P +++ A S P+
Sbjct: 252 PARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 308
Query: 717 PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPW 776
P + P PP P + LP PP P +P AP P P AP
Sbjct: 309 PSGTKARPVPP-----------PDNAATPLPATLPPSP----PLATPLPLAP-PSPSAPP 352
Query: 777 AFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRS 836
+ L PPATPP P + + P + + + S +L P
Sbjct: 353 SLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP-----SLQAPPSPL 407
Query: 837 ALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPK 896
AL S+ T + G+P Q A + P L+S S P+ PP P
Sbjct: 408 AL----SSLQATTSLGSPTLQ--ATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPL 461
Query: 897 E-GATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEP-GPEGT---PPSRGSSGEGLP 951
A+ P + +LS P P P S P P + PP S P
Sbjct: 462 SLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPP 521
Query: 952 FAEEGNLTIKQRP----KPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALL 1007
+ ++ P PPP +T P +L P C PLQ
Sbjct: 522 SLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHL-------ETPPCPAPCPLQA--- 571
Query: 1008 AFGVASATPGPAAPLPSPTPGESPPASSLPQPEP----SSLPAQGVPTP----LAPSPAM 1059
P +PL +P P E+P + + P P+ +S P QG+P+P LA P
Sbjct: 572 ----------PPSPLTTPPP-ETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQ 620
Query: 1060 QPP---VPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG 1116
PP +PP P PPA+P + AP ++V Q FS
Sbjct: 621 APPXLALPPLQAP-------------PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 667
Query: 1117 PKLAPRLGPRPVPPPRPESTGTVGPGQAQQRL 1148
P P P P P S P QA L
Sbjct: 668 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 699
Score = 41.6 bits (96), Expect = 0.005
Identities = 58/245 (23%), Positives = 85/245 (34%), Gaps = 33/245 (13%)
Query: 964 PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 1023
P+P G P PV P L + V R+P + A + A P +A
Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86
Query: 1024 SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 1062
S P PPAS + P P S P + P PL A +
Sbjct: 87 SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146
Query: 1063 VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1118
P S+ A R +G T +PA + AGT P+P A + GP+
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206
Query: 1119 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1171
+ P P RP + G + A + L +++ L++ R+ + GT
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 265
Query: 1172 EGTPS 1176
PS
Sbjct: 266 PAHPS 270
Score = 37.7 bits (86), Expect = 0.066
Identities = 47/189 (24%), Positives = 68/189 (35%), Gaps = 29/189 (15%)
Query: 998 EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 1057
+R+ + A A+ PG P P +P PP + P++L G + P
Sbjct: 4 KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57
Query: 1058 ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1107
A P P GP + +SR N + PPA+ P T+P PVS
Sbjct: 58 LAERAGGIGGATIPESAPRAGPTRSAGTSSR-NPASRPPASGRGERAPPAKNTSPGPVSS 116
Query: 1108 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1167
+ P GP R + TV G+A T + +AL A +
Sbjct: 117 PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 164
Query: 1168 TKEQEGTPS 1176
+ GTPS
Sbjct: 165 SGPTPGTPS 173
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 108 bits (269), Expect = 4e-23
Identities = 147/537 (27%), Positives = 190/537 (35%), Gaps = 97/537 (18%)
Query: 631 ALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPL 690
ALS G RR GP P T P + + A G P P P
Sbjct: 146 ALSAGARRDTSGPT------------PGTPSPAMARRSRA-------AGTEVGLPRPAPS 186
Query: 691 PPARSPSQESIGARSRGSGHSQEQPAP----QPSGGDPSPPQERNLPEGTERPPKLCSSL 746
R P++ + S S HS +P+P +PS G G +RP S
Sbjct: 187 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG-----------GLQRPASRSLS- 234
Query: 747 PGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP-- 804
S ++P P P A G P P P +PK + RP
Sbjct: 235 ---------------SSATPLSSPARSGPSA----RGTPRAPAHPSQPKPKGLQALRPPQ 275
Query: 805 -GPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSA----LVRTSPSVTPTPARGTPRSQSF 859
P DA A GP+ S+ + + + P SA SP TP P++ T S
Sbjct: 276 VTPPRKDA-APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP-PSQATTSLGSP 333
Query: 860 ALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGP 919
L+A P PP LS ++ P P+ PP P P + P S P P P P
Sbjct: 334 TLQATHSFLPSPP---LSPLATPPPQAPPALALP-PLQAPPSP---PASPPLSPLATPSP 386
Query: 920 PAPAGPASDTEEEEPGPEGTPPSRG--SSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 977
AP A + P +PP + S P + + P A PP + P P
Sbjct: 387 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 446
Query: 978 PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 1037
P + + P PLQ A P P AP T PP +LP
Sbjct: 447 PASPPMSPSATPPPQAPPPLAAPPLQL---------AKPPPQAPPALAT----PPLQALP 493
Query: 1038 QPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPG 1097
P P+S P Q +P A P PP P + AA PPA+P L+ P
Sbjct: 494 SP-PASFPGQAPFSPSASLPMSPLATPPPQAPPV--LAAPLLQVPPSPPASPT--LQAPR 548
Query: 1098 AGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPP-RPESTGTVGPGQAQQRLEQTSS 1153
P P + SGP+L L P P PPP R S+ GP A TS+
Sbjct: 549 RPPTPGP------DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599
Score = 103 bits (258), Expect = 8e-22
Identities = 134/476 (28%), Positives = 166/476 (34%), Gaps = 73/476 (15%)
Query: 763 PSSPAPGPPPGAPWAFSYLA-----------------GPPATPPDPPR--PKRRSHS-LS 802
P SP P PPP P A L G P PR P R S S
Sbjct: 30 PGSPRP-PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS 88
Query: 803 RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARG----TPRSQS 858
G A+ + GPV S A+ T RPG S T ARG P+ +
Sbjct: 89 GRGERAPPAKNTSPGPVSSP--GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 146
Query: 859 FALRARRK------GPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAG 912
+ ARR G P P R S +G P S P+ GPR+ S
Sbjct: 147 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206
Query: 913 PSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPR 972
+ P P A P++ G P SR S P + R P P
Sbjct: 207 STTEPSPAARRRPSAG------GGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260
Query: 973 ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAP-----LPSP-- 1025
P P GL T R+ PL ++ LA SA P P+AP LPSP
Sbjct: 261 SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320
Query: 1026 TPGE-------------------SPPASSLPQPEPSSLPAQGVPTPLA-PSPAMQPPVPP 1065
TP SPP S L P P + PA +P A PSP PP+ P
Sbjct: 321 TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP 380
Query: 1066 CPGPGLESS---AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKL-AP 1121
P ++ A PP +P ++ P + A PVS + T + + P L AP
Sbjct: 381 LATPSPQAPNALAVHLLQAPFSPPPSPP--VQAPFSPPASPPVSPSATPPSQAPPSLAAP 438
Query: 1122 RLGPRPVPPPRPE-STGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1176
L P PP P S P QA L LA A ++ T + PS
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPS 494
Score = 93.2 bits (230), Expect = 1e-18
Identities = 131/541 (24%), Positives = 182/541 (33%), Gaps = 68/541 (12%)
Query: 657 PATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPA 716
PA +GP + +G+ +P + G + L P P +++ A S P+
Sbjct: 243 PARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 299
Query: 717 PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPW 776
P +PP + LP PP ++ G + P SP PPP AP
Sbjct: 300 PSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP 359
Query: 777 AFSY--LAGPPATPPDPPRPKRRSHSLSRPGP-----TEGDAEGEAEGPVGSTLGSYATL 829
A + L PP+ P PP + S P + PV + A+
Sbjct: 360 ALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 419
Query: 830 TRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPP--PPPKRLSSVSGPSPEP- 886
P + + PS+ P + P + + PPP PPP + P P
Sbjct: 420 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479
Query: 887 -------PPLDESPGPKEGATG--PRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPE 937
PPL P P G P + S P P P P AP A+ + P P
Sbjct: 480 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 539
Query: 938 GTPPSRGSSGEGLPFAEEG----NLTIKQRPKPAGPPPRE-TPVPPGLDFNLTESDTVKR 992
+P + P + LT+ P P PP R + G D S
Sbjct: 540 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599
Query: 993 RPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTP 1052
+ R G S G AA P PP + L P++ ++G P
Sbjct: 600 PEELR------------GYDSGPEGGAAASP-------PPDAELAACHPAAW-SRGPAPP 639
Query: 1053 LA--PSPAMQPPVPPCPGPGLESSAASRWNGETEPP----AAPAALLKVPGAGTAPKPVS 1106
LA +P P PP GPG + + ETE P AP AL P GT+ +
Sbjct: 640 LAFRGAPGAPLPWPPATGPGSADGLCTIY--ETEGPESATPAPGALDPGPSPGTSGGKAA 697
Query: 1107 VACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSI 1166
A S RLG P+ G Q + Q S L AAE +
Sbjct: 698 AGAGAGASSRSPKQARLGELPL-------------GALQASVVQHLLSRTLLLAAAEGAA 744
Query: 1167 G 1167
G
Sbjct: 745 G 745
Score = 42.7 bits (99), Expect = 0.002
Identities = 61/245 (24%), Positives = 87/245 (35%), Gaps = 42/245 (17%)
Query: 964 PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 1023
P+P G P PV P L + V R+P A A G+ AT +AP
Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKP---------LAERAGGIGGATIPESAPRA 77
Query: 1024 SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 1062
PT PPAS + P P S P + P PL A +
Sbjct: 78 GPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 137
Query: 1063 VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1118
P S+ A R +G T +PA + AGT P+P A + GP+
Sbjct: 138 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 197
Query: 1119 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1171
+ P P RP + G + A + L +++ L++ R+ + GT
Sbjct: 198 KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 256
Query: 1172 EGTPS 1176
PS
Sbjct: 257 PAHPS 261
Score = 32.3 bits (72), Expect = 2.8
Identities = 46/189 (24%), Positives = 64/189 (33%), Gaps = 38/189 (20%)
Query: 998 EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 1057
+R+ + A A+ PG P P +P PP + P++L G + P
Sbjct: 4 KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57
Query: 1058 ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1107
A P P GP S + GE PPA T+P PVS
Sbjct: 58 LAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPA----------KNTSPGPVSS 107
Query: 1108 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1167
+ P GP R + TV G+A T + +AL A +
Sbjct: 108 PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 155
Query: 1168 TKEQEGTPS 1176
+ GTPS
Sbjct: 156 SGPTPGTPS 164
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 106 bits (265), Expect = 1e-22
Identities = 75/213 (35%), Positives = 110/213 (51%), Gaps = 12/213 (5%)
Query: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA--WQGRLEPVRLLLRASA 106
G +ALH A G ++ L++ A V+ ++NG PLH+AA G L + LL+ A
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGA 272
Query: 107 AVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQL 166
VN S DG+ PLH+ A +G + S+ L+Q+ V+K TPL +A +G +L
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH----EL 328
Query: 167 LLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TAL 225
L+N+ G C + PLHLAA N H + R+LL +G EI+ K G T L
Sbjct: 329 LINT----LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
Query: 226 HEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
H AA G E ++LL G D + ++ +T L
Sbjct: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Score = 103 bits (257), Expect = 1e-21
Identities = 76/224 (33%), Positives = 117/224 (52%), Gaps = 9/224 (4%)
Query: 38 KRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
K +VN D++ + LH AA G E+I LL+ + A V+ KD+ + PLH A E
Sbjct: 5 KTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64
Query: 98 VRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACE 157
V++L++ SA VNA + Q PLH+AA + +E+++ S+ + ++ +T L A
Sbjct: 65 VQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAAL 124
Query: 158 FGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR 217
G +++ LL L +G + D LH AA GH +V+ L+ G E+
Sbjct: 125 NGHVEMVNLL--------LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
+ K G T LH AA G+ VV+ LL GV+++ N Y TAL I
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Score = 102 bits (254), Expect = 2e-21
Identities = 72/226 (31%), Positives = 111/226 (49%), Gaps = 10/226 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN D G +ALHHAAL G +E++ LLL A ++ D R LH+AA+ G L+ V L
Sbjct: 107 SVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ A V G PLH AA G V + LL +N T L +AC G+
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL-RAGIEINRQT 219
V L++ G + + N TPLH AA + H + +LL G ++N Q+
Sbjct: 227 DAVVNELID--------YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 220 KTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQF 264
K G + LH A++G+ + L++ G +++ + T L + ++
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARY 324
Score = 99.8 bits (247), Expect = 1e-20
Identities = 72/233 (30%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN +D + + LH AA +++ +++ ++V++ D G LH+AA G +E V L
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
LL A +NA + LH AA GH +V +L+ H + +K TPL A G+
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 193
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+ V + LLN G D + T LH+A NG V+ +L+ G +N+
Sbjct: 194 INVVKHLLNL--------GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN 245
Query: 221 TG-TALHEAALYGKTEV-VRLLLEGGVDVNIRNTYNQTALDIV---NQFTTSQ 268
G T LH AA + + LL+ G DVNI++ ++ L + +FT SQ
Sbjct: 246 NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Score = 83.6 bits (205), Expect = 1e-15
Identities = 69/228 (30%), Positives = 112/228 (49%), Gaps = 21/228 (9%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLE-AQATVDIKDSNGMR-PLHYAAWQGRLEPV 98
N + +D +G++++H+AA G + + LLLE + + DS + PLH AA+ G + +
Sbjct: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558
Query: 99 RLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV-NKAKKTPLDLACE 157
+LL++ ++ G+ L LAA GH E E L+ ++ + N K+TPL +
Sbjct: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHAS-- 616
Query: 158 FGRLKVAQLLLNSH-LCVALL-----EGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRA 211
++N H LC+ LL EA D D TPL LA GH + + LL
Sbjct: 617 ---------VINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK 667
Query: 212 GIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
++ G TALH + G E V++LLE V + +++ +T L
Sbjct: 668 EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715
Score = 81.3 bits (199), Expect = 5e-15
Identities = 72/223 (32%), Positives = 94/223 (42%), Gaps = 15/223 (6%)
Query: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
V+ +DA G + L A G ++ ++LLLE +A VD D G LH G E V++L
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ---HQSNPCLVNKAKKTPLDLACEF 158
L ++ G+ PLH AA GH LLQ + + C + TPL AC
Sbjct: 698 LEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYN 757
Query: 159 GRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRA---GIEI 215
G N + LLE + N TPLH A N H LL A I
Sbjct: 758 G---------NENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
Query: 216 NRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
R K T L AA E ++LLL VN + +TAL
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851
Score = 79.7 bits (195), Expect = 2e-14
Identities = 75/257 (29%), Positives = 112/257 (43%), Gaps = 43/257 (16%)
Query: 37 TKRLNVNYQDADGFSALHHAA----------LGGSLE------------------LIALL 68
T NVN D G +ALH+AA LG + + + L
Sbjct: 434 TTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFL 493
Query: 69 LEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDG--QIPLHLAAQYG 126
L+ A I+D G +HYAA G + + LLL + + S G + PLHLAA G
Sbjct: 494 LQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNG 553
Query: 127 HYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCD 186
H++ E+LLQ + + ++ +T LDLA G + + L+N + + + K
Sbjct: 554 HHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK---- 609
Query: 187 PNYTTPLHLAAKNGHREVIRQLLR-----AGIEINRQTKTGTALHEAALYGKTEVVRLLL 241
TPLH + NGH +R LL +++ + K T L A YG + V LLL
Sbjct: 610 ---RTPLHASVINGHTLCLRLLLEIADNPEAVDV-KDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 242 EGGVDVNIRNTYNQTAL 258
E +V+ + TAL
Sbjct: 666 EKEANVDTVDILGCTAL 682
Score = 76.6 bits (187), Expect = 1e-13
Identities = 61/190 (32%), Positives = 80/190 (42%), Gaps = 9/190 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN Q DG S LH A+ G L++ +D D +G PLH AA G +
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L + A + PLHLAA H + LL +K +T L A G
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
++ +LL +S + KD C TPLH AA N H I L+ G +N
Sbjct: 393 VECIKLLQSSG-----ADFHKKDKCG---RTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 221 TG-TALHEAA 229
G TALH AA
Sbjct: 445 WGRTALHYAA 454
Score = 75.9 bits (185), Expect = 2e-13
Identities = 65/213 (30%), Positives = 98/213 (46%), Gaps = 16/213 (7%)
Query: 38 KRLNVNYQDADGF---SALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGR 94
+R N ++++D S LH AA G + + +LL++ +DI+D G L AA++G
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587
Query: 95 LEPVRLLLRASAAVNAA-SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN--KAK-KT 150
E V L+ A++ ++ + PLH + GH +LL+ NP V+ AK +T
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
Query: 151 PLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR 210
PL LA +G + LLL V D D T LH GH E ++ LL
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKEANV--------DTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 211 AGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 242
+ I + G T LH AA G + LL+
Sbjct: 700 QEVSILCKDSRGRTPLHYAAARGHATWLSELLQ 732
Score = 75.5 bits (184), Expect = 3e-13
Identities = 66/231 (28%), Positives = 100/231 (43%), Gaps = 23/231 (9%)
Query: 53 LHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAAS 112
LH AAL + LL + +D D G LH AA G +E ++LL + A +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 113 LDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH- 171
G+ PLH AA H+ E L+ +N + +T L A + +L N+H
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
Query: 172 -----------------LCVALLEGEAKDPC--DPNYTTPLHLAAKNGHREVIRQLL--- 209
LC+ L +P D +H AA GHR+ + LL
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 210 RAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
+G E + T + LH AA G + + +LL+ VD++IR+ +TALD+
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Score = 74.3 bits (181), Expect = 6e-13
Identities = 74/259 (28%), Positives = 110/259 (42%), Gaps = 25/259 (9%)
Query: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
L+LAV G + V L+ K NV+ D G +ALH + G E +
Sbjct: 649 LMLAVAYGHIDAVSLLLEK-------------EANVDTVDILGCTALHRGIMTGHEECVQ 695
Query: 67 LLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASL---DGQIPLHLAA 123
+LLE + ++ KDS G PLHYAA +G + LL+ + + G PLH A
Sbjct: 696 MLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWAC 755
Query: 124 QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKD 183
G+ E+LL+ + + TPL A A LLL + ++
Sbjct: 756 YNGNENCIEVLLEQKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGA------IDSSIVS 808
Query: 184 PCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 242
D TPL AA H E ++ LLR +N +G TAL AA G+ V +L+
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Query: 243 GG-VDVNIRNTYNQTALDI 260
D+ +++ T L +
Sbjct: 869 SAQADLTVKDKDLNTPLHL 887
Score = 64.3 bits (155), Expect = 7e-10
Identities = 50/162 (30%), Positives = 74/162 (45%), Gaps = 10/162 (6%)
Query: 44 YQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR 103
++D G++ LH A G+ I +LLE + N PLH A LLL
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI-GNPFTPLHCAIINDHGNCASLLLG 800
Query: 104 A--SAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161
A S+ V+ G+ PL AA H E ++LL+H + V+ + KT L +A E G+
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHRE 203
+L+NS ++ D + TPLHLA GH +
Sbjct: 861 GAVDILVNSAQADLTVK-------DKDLNTPLHLACSKGHEK 895
Score = 61.6 bits (148), Expect = 4e-09
Identities = 44/123 (35%), Positives = 65/123 (52%), Gaps = 3/123 (2%)
Query: 50 FSALHHAALGGSLELIALLLEA--QATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAA 107
F+ LH A + +LLL A + V +D G PL AA+ +E ++LLLR SA
Sbjct: 780 FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
Query: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQH-QSNPCLVNKAKKTPLDLACEFGRLKVAQL 166
VNA G+ L +AA+ G ++L+ Q++ + +K TPL LAC G K A L
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 167 LLN 169
+L+
Sbjct: 900 ILD 902
Score = 50.8 bits (120), Expect = 8e-06
Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Query: 33 LLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQ 92
LLG+ V+ +D G + L AA +E + LLL A V+ D++G L AA
Sbjct: 798 LLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAEN 857
Query: 93 GRLEPVRLLLR-ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNK 146
G+ V +L+ A A + D PLHLA GH + + ++L + L+N+
Sbjct: 858 GQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 106 bits (265), Expect = 1e-22
Identities = 78/228 (34%), Positives = 110/228 (48%), Gaps = 14/228 (6%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
N+N+ D DG++AL AA GG E+++ LL A VD D++ L AAW G + V
Sbjct: 603 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA----- 155
LL+ A VN A +G+ L AA GH E+ E LL H + + +T L +A
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722
Query: 156 CEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEI 215
G V LL++ G D CD + TPL +AA GH +V+ LL G ++
Sbjct: 723 ASKGHASVVSLLID--------RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
Query: 216 NRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262
+ G T L AA G VV LL G V+ ++ +T L I +
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Score = 97.4 bits (241), Expect = 7e-20
Identities = 81/261 (31%), Positives = 125/261 (47%), Gaps = 34/261 (13%)
Query: 42 VNYQDADGFSALHHAAL-----GGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
VN++D DG +AL AAL G +++LL++ A VD D +GM PL AA++G ++
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 97 PVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLAC 156
V LLL A V+ +G+ PL AA GH V LL + ++ +T L +A
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Query: 157 EFGRLKVAQLLLNSHL------------------------CVALLE-GEAKDPCDPNYTT 191
G ++V + LL+ L C AL+E G + D +
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
Query: 192 PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 250
P LA++ GH + ++ LL I+++ G AL AAL G ++V LL G DVN +
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 251 NTYNQTALDIV---NQFTTSQ 268
+ + L I+ NQ T ++
Sbjct: 943 DADGRPTLYILALENQLTMAE 963
Score = 93.6 bits (231), Expect = 1e-18
Identities = 78/225 (34%), Positives = 104/225 (46%), Gaps = 14/225 (6%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
+ V+ DAD +AL AA GG +++ LL+ A V+ D+ G L AA+ G E V
Sbjct: 635 VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694
Query: 100 LLLRASAAVNAASLDGQIPLHLA-----AQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDL 154
LL A VN +DG+ L +A A GH V +L+ + +K TPL +
Sbjct: 695 HLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLV 754
Query: 155 ACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIE 214
A G + V LLL G D D N TPL AA GH V+ LL G
Sbjct: 755 AAYEGHVDVVDLLLEG--------GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 215 INRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
++ G T L A+ G EVVR LL+ G+D N R+ T L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851
Score = 91.7 bits (226), Expect = 4e-18
Identities = 61/205 (29%), Positives = 105/205 (51%), Gaps = 9/205 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
N++ + DG +AL AAL G +++ LL A V+ KD++G L+ A + +L
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L A V A+ +G+ LH++ GH E+ ++L+ + ++ + K++ L A G
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+KV QLL+ G D T L +AA+ GH +V++ LL G + N +
Sbjct: 1025 VKVVQLLIE--------HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQ 1076
Query: 221 TG-TALHEAALYGKTEVVRLLLEGG 244
G TA+ AA G +++++LL + G
Sbjct: 1077 FGRTAMRVAAKNGHSQIIKLLEKYG 1101
Score = 90.1 bits (222), Expect = 1e-17
Identities = 73/214 (34%), Positives = 103/214 (48%), Gaps = 14/214 (6%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN D++G + L +AA GSL+++ LL+ A ++I+D++G PL AA QG + V
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNC 596
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ A +N DG L AA GH EV LL + +T L A G
Sbjct: 597 LIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGH 656
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
++LN L G + D T L AA GHRE++ LL G E+N +
Sbjct: 657 ---EDIVLN-----LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 708
Query: 221 TG-TALHEAAL-----YGKTEVVRLLLEGGVDVN 248
G TAL AAL G VV LL++ G +V+
Sbjct: 709 DGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
Score = 87.0 bits (214), Expect = 1e-16
Identities = 74/221 (33%), Positives = 106/221 (47%), Gaps = 11/221 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+VN +D D S + AL + I LL+ A+V+ DSNG L AA+ G L+ V L
Sbjct: 506 HVNSED-DRTSCIVRQALERE-DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ A + G PL LAA+ GH +V L+ +N ++ T L A G
Sbjct: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
+V LL + G D D + T L AA GH +++ LL+ G E+N+
Sbjct: 624 TEVVSALLYA--------GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADN 675
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G TAL AA G E+V LL+ G +VN + +TAL +
Sbjct: 676 EGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Score = 85.5 bits (210), Expect = 3e-16
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 9/227 (3%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N D DG A+ G + + +LLE ++ +D + +G L AA +G + V LL
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
A VN DG+ L++ A ++E L++ +N + +T L ++C G ++
Sbjct: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHME 993
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
+ Q+L+ H V + E + + L AA GH +V++ L+ G ++ G
Sbjct: 994 MVQVLIAYHADVNAADNEKR--------SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQG 1045
Query: 223 -TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQ 268
TAL AA G +VV++LLE G D N + + +TA+ + + SQ
Sbjct: 1046 ATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ 1092
Score = 83.6 bits (205), Expect = 1e-15
Identities = 69/250 (27%), Positives = 119/250 (47%), Gaps = 14/250 (5%)
Query: 16 VTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATV 75
V + V+ +T L + L+ N++D G++ LH AA G + L+E A
Sbjct: 817 VLSIASAQGNVEVVRTLL---DRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Query: 76 DIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLL 135
+ D++G P A+ +G + V++LL + ++ DG+ L +AA GH ++ E+L
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 136 QHQSN-PCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLH 194
H ++ C + T LA E +L +A+ L + V + E + T LH
Sbjct: 934 SHGADVNCKDADGRPTLYILALE-NQLTMAEYFLENGANVEASDAEGR--------TALH 984
Query: 195 LAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTY 253
++ GH E+++ L+ ++N + +AL AA G +VV+LL+E G V+
Sbjct: 985 VSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ 1044
Query: 254 NQTALDIVNQ 263
TAL I Q
Sbjct: 1045 GATALCIAAQ 1054
Score = 78.6 bits (192), Expect = 3e-14
Identities = 63/221 (28%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
+V++ D +G + L AA G ++ LL A VD DS G L A+ QG +E VR
Sbjct: 773 DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
LL N G PLH+AA GH + E L++ + ++ + P LA + G
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
Q+LL + + D + L +AA GHR+++ L G ++N +
Sbjct: 893 YDCVQILLENKSNI--------DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Query: 221 TG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
G L+ AL + + LE G +V + +TAL +
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHV 985
Score = 77.8 bits (190), Expect = 6e-14
Identities = 54/192 (28%), Positives = 96/192 (50%), Gaps = 10/192 (5%)
Query: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
NV DA+G +ALH + G +E++ +L+ A V+ D+ L AAWQG ++ V+L
Sbjct: 971 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 1030
Query: 101 LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGR 160
L+ A V+ G L +AAQ GH +V ++LL+H ++P ++ +T + +A + G
Sbjct: 1031 LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGH 1090
Query: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
++ +LL + L G C P +P+H + + + ++ I+ N
Sbjct: 1091 SQIIKLL--EKYGASSLNG-----CSP---SPVHTMEQKPLQSLSSKVQSLTIKSNSSGS 1140
Query: 221 TGTALHEAALYG 232
TG + +L G
Sbjct: 1141 TGGGDMQPSLRG 1152
Score = 32.3 bits (72), Expect = 2.8
Identities = 22/82 (26%), Positives = 40/82 (48%), Gaps = 10/82 (12%)
Query: 202 REVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVN---------IRNT 252
+EV++ L++AG +N + + + AL + + +R LL+ G VN + N
Sbjct: 494 QEVLQLLVKAGAHVNSEDDRTSCIVRQAL-EREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 253 YNQTALDIVNQFTTSQASREIK 274
+LD+VN + A EI+
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIE 574
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 105 bits (263), Expect = 2e-22
Identities = 88/296 (29%), Positives = 135/296 (45%), Gaps = 38/296 (12%)
Query: 4 EQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLE 63
E+ L A + +V +Q+L+ + R+N ++ G ALH AA G +
Sbjct: 16 ERQLHEAARQNNVGRMQELIGR-------------RVNTRARNHVGRVALHWAAGAGHEQ 62
Query: 64 LIALLLEAQATVDIKDSNG----------MRPLHYAAWQGRLEPVRLLLRASAAVNAASL 113
+ LLLE +A VD +D+ G M L +AW G L +++L+ + A ++ S
Sbjct: 63 AVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESK 122
Query: 114 DGQIPLHLAAQYGHYEVSEMLLQHQSNPCL--VNKAKKTPLDLACEFGRLKVAQLLLNSH 171
DG LH AAQ GH V +++ + L V+K +T A E G+L L+ S
Sbjct: 123 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGS- 181
Query: 172 LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
G + D T LHLAA GH V+++L+ G+++ Q G TALH AA
Sbjct: 182 -------GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
Query: 231 YGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
+ V+LLL G VN N + L + S ++ ++L A G V
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCL----HYAALSGSEDVSRVLIHAGGCANV 286
Score = 84.7 bits (208), Expect = 5e-16
Identities = 62/201 (30%), Positives = 104/201 (51%), Gaps = 9/201 (4%)
Query: 43 NYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102
N +D +G +ALH AA G + ++ L++ ++ +++ G+ LH AA + V+LLL
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 245
Query: 103 RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLK 162
RA + VNA + LH AA G +VS +L+ +V+ +PL LA
Sbjct: 246 RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 305
Query: 163 VAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG 222
+ +LL+NS V + D TPLHLAA++ +++ LL AG+++N + K G
Sbjct: 306 LVRLLINSDSDV--------NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357
Query: 223 -TALHEAALYGKTEVVRLLLE 242
TAL A +V ++++
Sbjct: 358 KTALAVAVRSNHVSLVDMIIK 378
Score = 82.4 bits (202), Expect = 2e-15
Identities = 56/220 (25%), Positives = 110/220 (50%), Gaps = 9/220 (4%)
Query: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
+++ D G +A H AA G L+ + L+ + ++KD G LH AA +G + ++ L
Sbjct: 152 LDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRL 211
Query: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161
+ + + +G LH AA H + ++LL+ S + + + L A G
Sbjct: 212 VDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSE 271
Query: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR-QTK 220
V+++L+++ C +++ + +PLHLA ++ ++R L+ + ++N +
Sbjct: 272 DVSRVLIHAGGCANVVDHQG--------ASPLHLAVRHNFPALVRLLINSDSDVNAVDNR 323
Query: 221 TGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
T LH AA + ++ +LL GVD+N+R+ +TAL +
Sbjct: 324 QQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAV 363
Score = 82.0 bits (201), Expect = 3e-15
Identities = 51/172 (29%), Positives = 88/172 (51%), Gaps = 8/172 (4%)
Query: 40 LNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVR 99
L++ Q+A+G +ALH AA G + + LLL A +TV+ + LHYAA G + R
Sbjct: 216 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 275
Query: 100 LLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFG 159
+L+ A N G PLHLA ++ + +L+ S+ V+ ++TPL LA E
Sbjct: 276 VLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 335
Query: 160 RLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRA 211
+A +LL + + + L + + K T L +A ++ H ++ +++A
Sbjct: 336 WQDIADMLLIAGVDLNLRDKQGK--------TALAVAVRSNHVSLVDMIIKA 379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,929,849
Number of Sequences: 37866
Number of extensions: 5276945
Number of successful extensions: 94814
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1116
Number of HSP's successfully gapped in prelim test: 2895
Number of HSP's that attempted gapping in prelim test: 25037
Number of HSP's gapped (non-prelim): 31416
length of query: 1202
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1088
effective length of database: 13,930,794
effective search space: 15156703872
effective search space used: 15156703872
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.