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Search of human proteins with 217272877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 702 0.0
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 581 e-166
gi|13128864 histone deacetylase 6 [Homo sapiens] 81 2e-15
gi|116284376 histone deacetylase 2 [Homo sapiens] 80 3e-15
gi|13128860 histone deacetylase 1 [Homo sapiens] 75 7e-14
gi|8923769 histone deacetylase 8 [Homo sapiens] 74 1e-13
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 68 1e-11
gi|13128862 histone deacetylase 3 [Homo sapiens] 68 1e-11
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 67 2e-11
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 67 2e-11
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 67 2e-11
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 64 3e-10
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 64 3e-10
gi|153085395 histone deacetylase 4 [Homo sapiens] 61 2e-09
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 59 8e-09
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 59 8e-09
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 53 4e-07
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 51 1e-06
gi|13129068 nucleolar complex associated 4 homolog [Homo sapiens] 29 5.4
gi|4557389 complement component 8, alpha polypeptide precursor [... 29 5.4
gi|169234778 potassium channel tetramerisation domain containing... 29 5.4
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 702 bits (1811), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 60
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
Sbjct: 1 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 60
Query: 61 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 120
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
Sbjct: 61 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 120
Query: 121 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 180
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
Sbjct: 121 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 180
Query: 181 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 240
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
Sbjct: 181 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 240
Query: 241 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 300
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
Sbjct: 241 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 300
Query: 301 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 347
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Sbjct: 301 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 347
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 581 bits (1498), Expect = e-166
Identities = 296/319 (92%), Positives = 296/319 (92%), Gaps = 23/319 (7%)
Query: 29 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFA 88
MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK
Sbjct: 1 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK---- 56
Query: 89 VATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR 148
RKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR
Sbjct: 57 -------------------RKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR 97
Query: 149 GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI 208
GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI
Sbjct: 98 GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI 157
Query: 209 YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 268
YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL
Sbjct: 158 YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217
Query: 269 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE 328
GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE
Sbjct: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE 277
Query: 329 SPSVSAQNSDTPLLPPAVP 347
SPSVSAQNSDTPLLPPAVP
Sbjct: 278 SPSVSAQNSDTPLLPPAVP 296
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 80.9 bits (198), Expect = 2e-15
Identities = 79/320 (24%), Positives = 131/320 (40%), Gaps = 32/320 (10%)
Query: 11 VPETRWPIVYSPR---YNITFMGLEKL----HPFDAGKWGKVINFLKEEKLLSDSMLVEA 63
+P WP++ S Y+ M L HP + +++ L+E L + +
Sbjct: 469 LPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTP 528
Query: 64 REASEEDLLVVHTRRYLNELKWSFAVAT------ITEIPPVIFLPNFLVQRKVLRPLRTQ 117
R A+E +LL H+ Y+ L+ + + T + + P+ ++ +
Sbjct: 529 RPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACR 588
Query: 118 TGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATI 177
+++G+ V G A+ G HH D GFC + + +A + R I
Sbjct: 589 LVEAVLSGE--VLNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAARHAQTISGHALRILI 645
Query: 178 IDLDAHQGNGHERDFMDDKRVYIMDVYNRH---IYP-GDRFAKQAIRRK------VELEW 227
+D D H GNG + F DD V + ++ +P GD A I R V + W
Sbjct: 646 VDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAW 705
Query: 228 GTE---DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDEL 284
D +YL R + E P++V+ +AG D GD LGG +SP G L
Sbjct: 706 NGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHL 765
Query: 285 VFRMVRGRRVPILMVTSGGY 304
+ + GR I+++ GGY
Sbjct: 766 LMGLASGR---IILILEGGY 782
Score = 70.5 bits (171), Expect = 2e-12
Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 46/320 (14%)
Query: 49 LKEEKLLSDSMLVEAREASEEDLLVVH---------TRRYLNELKWSFAVATITEI--PP 97
L +E LL + +AR A +E+L++VH T +Y+NE + T + P
Sbjct: 119 LIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 178
Query: 98 VIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYAD 157
+ L VLR + G I G AI G HH G+C +
Sbjct: 179 NSYSCACLASGSVLRLVDAVLGAEI-------RNGMAIIRPPG-HHAQHSLMDGYCMFNH 230
Query: 158 ITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAK- 216
+ +A ++ ++ I R I+D D H G G + F D V + H Y RF
Sbjct: 231 VAVAARYAQQK-HRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSI---HRYEQGRFWPH 286
Query: 217 ------------QAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTD 261
Q + + W G D +Y+ + E P +V+ AG D
Sbjct: 287 LKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFD 346
Query: 262 ILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRT-ARIIADSILNLF 320
L+GD G ++ +PAG + L+ + G+ +++ GGY R A ++ S+ L
Sbjct: 347 ALQGDPKGEMAATPAGFAQLTHLLMGLAGGK---LILSLEGGYNLRALAEGVSASLHTLL 403
Query: 321 G---LGLIGPESPSVSAQNS 337
G L P +P SAQ S
Sbjct: 404 GDPCPMLESPGAPCRSAQAS 423
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 80.1 bits (196), Expect = 3e-15
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 19/201 (9%)
Query: 118 TGGTIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISR 174
TGG++ AG + + R A+N GG HH GFC DI LAI E ++ R
Sbjct: 209 TGGSV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQR 264
Query: 175 ATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIY-PGDRFAKQAIRRKVE-------LE 226
ID+D H G+G E F RV + + Y PG + K + +
Sbjct: 265 VLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMR 324
Query: 227 WGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVF 286
G +D+ Y + I K ++ + P VV G D L GDRLG +++ G K E
Sbjct: 325 DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVE--- 381
Query: 287 RMVRGRRVPILMVTSGGYQKR 307
+V+ +P+LM+ GGY R
Sbjct: 382 -VVKTFNLPLLMLGGGGYTIR 401
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 75.5 bits (184), Expect = 7e-14
Identities = 61/200 (30%), Positives = 89/200 (44%), Gaps = 17/200 (8%)
Query: 118 TGGTIMAG-KLAVER-GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRA 175
TGG++ + KL ++ A+N GG HH GFC DI LAI E ++ R
Sbjct: 114 TGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRV 170
Query: 176 TIIDLDAHQGNGHERDFMDDKRVYIMDVYN-RHIYPGDRFAKQAIRRK-------VELEW 227
ID+D H G+G E F RV + + +PG + K L
Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRD 230
Query: 228 GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFR 287
G +D+ Y + + K ++ P VV G+D L GDRLG +++ G K E
Sbjct: 231 GIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVE---- 286
Query: 288 MVRGRRVPILMVTSGGYQKR 307
V+ +P+LM+ GGY R
Sbjct: 287 FVKSFNLPMLMLGGGGYTIR 306
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 74.3 bits (181), Expect = 1e-13
Identities = 78/307 (25%), Positives = 124/307 (40%), Gaps = 27/307 (8%)
Query: 19 VYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSM-LVEAREASEEDLLVVHTR 77
+YSP Y L K+ K +++ L E L M +V+ + AS E++ HT
Sbjct: 19 IYSPEYVSMCDSLAKIP-----KRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTD 73
Query: 78 RYLNELKWSFAVATITEIPPVIFLPNF--LVQRKVLRPLRTQTGGTIMAGKLAVERGW-- 133
YL L+ + + + + G TI A + ++
Sbjct: 74 AYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKV 133
Query: 134 AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFM 193
AIN GG+HH D GFC D L I L + E R +DLD H G+G E F
Sbjct: 134 AINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFE---RILYVDLDLHHGDGVEDAFS 190
Query: 194 DDKRVYIMDV--YNRHIYPGDRFAKQAIRRK-------VELEWGTEDDEYLDKVERNIKK 244
+V + + ++ +PG K V ++ G +D++Y E +K+
Sbjct: 191 FTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKE 250
Query: 245 SLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 304
Q P VV G D + GD + +++P GI K + + ++ L++ GGY
Sbjct: 251 VYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGK----CLKYILQWQLATLILGGGGY 306
Query: 305 Q-KRTAR 310
TAR
Sbjct: 307 NLANTAR 313
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 68.2 bits (165), Expect = 1e-11
Identities = 77/315 (24%), Positives = 131/315 (41%), Gaps = 36/315 (11%)
Query: 49 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV------ATITEIPPVIFLP 102
L++ L + + AREASEE+L +VH+ Y++ ++ + + A + + F P
Sbjct: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
Query: 103 NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAI 162
+ ++ Q ++ G AV+ G A+ G HH GFC + ++ +A
Sbjct: 98 STFHCARLAAGAGLQLVDAVLTG--AVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAA 154
Query: 163 KFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF-------- 214
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 155 AHAKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESD 210
Query: 215 -----AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGD 266
Q + V L W G + +Y+ + E P++V+ +AG D GD
Sbjct: 211 ADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGD 270
Query: 267 RLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---L 322
G + +P +L+ + GR + V GGY + A + ++ L G
Sbjct: 271 PEGQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAP 327
Query: 323 GLIGPESPSVSAQNS 337
L GP +P SA S
Sbjct: 328 PLSGPMAPCQSALES 342
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 16/183 (8%)
Query: 134 AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFM 193
AIN GG HH GFC DI + I E ++ R ID+D H G+G + F
Sbjct: 126 AINWAGGLHHAKKFEASGFCYVNDIVIGI---LELLKYHPRVLYIDIDIHHGDGVQEAFY 182
Query: 194 DDKRVYIMDV--YNRHIYP--GDRFAKQAIRRK-----VELEWGTEDDEYLDKVERNIKK 244
RV + Y + +P GD + A + V L G +D Y + I +
Sbjct: 183 LTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQ 242
Query: 245 SLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 304
+ + P +V G D L DRLG ++S G E V V+ +P+L++ GGY
Sbjct: 243 VVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRG---HGECV-EYVKSFNIPLLVLGGGGY 298
Query: 305 QKR 307
R
Sbjct: 299 TVR 301
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 67.4 bits (163), Expect = 2e-11
Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 709
Query: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
++ P I L + +K L R G I +A K
Sbjct: 710 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
Query: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 825
Query: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230
GNG ++ F D + + ++ + +PG + + + W G +
Sbjct: 826 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 885
Query: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287
D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + +
Sbjct: 886 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 945
Query: 288 MVRGRRVPILMVTSGGY 304
+ GR +++ GG+
Sbjct: 946 LADGR---VVLALEGGH 959
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 67.4 bits (163), Expect = 2e-11
Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706
Query: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
++ P I L + +K L R G I +A K
Sbjct: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822
Query: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230
GNG ++ F D + + ++ + +PG + + + W G +
Sbjct: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 882
Query: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287
D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + +
Sbjct: 883 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 942
Query: 288 MVRGRRVPILMVTSGGY 304
+ GR +++ GG+
Sbjct: 943 LADGR---VVLALEGGH 956
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 67.4 bits (163), Expect = 2e-11
Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706
Query: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
++ P I L + +K L R G I +A K
Sbjct: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822
Query: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230
GNG ++ F D + + ++ + +PG + + + W G +
Sbjct: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 882
Query: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287
D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + +
Sbjct: 883 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 942
Query: 288 MVRGRRVPILMVTSGGY 304
+ GR +++ GG+
Sbjct: 943 LADGR---VVLALEGGH 956
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 63.5 bits (153), Expect = 3e-10
Identities = 71/312 (22%), Positives = 128/312 (41%), Gaps = 41/312 (13%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 81
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 700 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 759
Query: 82 ELKWSFA--VATITE-IPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG 138
K + I++ + V+ V + + MA +E + + G
Sbjct: 760 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 819
Query: 139 ---GGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 188
GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 820 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 878
Query: 189 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 234
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 879 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 938
Query: 235 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 292
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 939 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 998
Query: 293 RVPILMVTSGGY 304
+++ GG+
Sbjct: 999 ---VVLALEGGH 1007
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 63.5 bits (153), Expect = 3e-10
Identities = 71/312 (22%), Positives = 128/312 (41%), Gaps = 41/312 (13%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 81
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 699 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 758
Query: 82 ELKWSFA--VATITE-IPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG 138
K + I++ + V+ V + + MA +E + + G
Sbjct: 759 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 818
Query: 139 ---GGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 188
GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 819 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 877
Query: 189 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 234
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 878 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 937
Query: 235 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 292
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 938 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 997
Query: 293 RVPILMVTSGGY 304
+++ GG+
Sbjct: 998 ---VVLALEGGH 1006
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 60.8 bits (146), Expect = 2e-09
Identities = 73/311 (23%), Positives = 120/311 (38%), Gaps = 40/311 (12%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 81
G HP AG+ + + L+E L + R+A+ E+L VH+ + LN
Sbjct: 670 GSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLN 729
Query: 82 ELKWSFAVATITEIPPVIFLP--NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG- 138
K + + LP V + G +A VE + + G
Sbjct: 730 RQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE 789
Query: 139 --GGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHE 189
GF HH GFC + + +A K L +R+ +S+ I+D D H GNG +
Sbjct: 790 LKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLS-VSKILIVDWDVHHGNGTQ 848
Query: 190 RDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-------AIRRKVELEWGTE----DDEYL 235
+ F D V M ++ + + +PG + + G + D EYL
Sbjct: 849 QAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYL 908
Query: 236 DKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGRR 293
+ E PDVV+ ++G D +EG LGG ++S + + + GR
Sbjct: 909 AAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR- 967
Query: 294 VPILMVTSGGY 304
I++ GG+
Sbjct: 968 --IVLALEGGH 976
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 58.5 bits (140), Expect = 8e-09
Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 40/278 (14%)
Query: 35 HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LNELKWS 86
HP AG+ + + L+E L S + R+AS E+L VH+ R+ L+ LK
Sbjct: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
Query: 87 FA-VATITEIPPVIFLPNFLV---QRKVLRPLRTQTGGTIMAGKLA----------VERG 132
+A + + LP V + L + AG + ++ G
Sbjct: 603 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 662
Query: 133 WAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDF 192
+A+ G HH GFC + + +A + L ++ + S+ I+D D H GNG ++ F
Sbjct: 663 FAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQTF 720
Query: 193 MDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDKV 238
D V + ++ + +PG + A V + W D EYL
Sbjct: 721 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 780
Query: 239 ERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 274
+ +E PD+V+ +AG D EG LGG +S
Sbjct: 781 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 818
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 58.5 bits (140), Expect = 8e-09
Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 40/278 (14%)
Query: 35 HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LNELKWS 86
HP AG+ + + L+E L S + R+AS E+L VH+ R+ L+ LK
Sbjct: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
Query: 87 FA-VATITEIPPVIFLPNFLV---QRKVLRPLRTQTGGTIMAGKLA----------VERG 132
+A + + LP V + L + AG + ++ G
Sbjct: 640 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 699
Query: 133 WAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDF 192
+A+ G HH GFC + + +A + L ++ + S+ I+D D H GNG ++ F
Sbjct: 700 FAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQTF 757
Query: 193 MDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDKV 238
D V + ++ + +PG + A V + W D EYL
Sbjct: 758 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 817
Query: 239 ERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 274
+ +E PD+V+ +AG D EG LGG +S
Sbjct: 818 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 855
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 53.1 bits (126), Expect = 4e-07
Identities = 44/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%)
Query: 49 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV------ATITEIPPVIFLP 102
L++ L + + AREASEE+L +VH+ Y++ ++ + + A + + F P
Sbjct: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
Query: 103 NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAI 162
+ ++ Q ++ G AV+ G A+ G HH GFC + ++ +A
Sbjct: 98 STFHCARLAAGAGLQLVDAVLTG--AVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAA 154
Query: 163 KFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF 214
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 155 AHAKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRF 202
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 51.2 bits (121), Expect = 1e-06
Identities = 51/211 (24%), Positives = 92/211 (43%), Gaps = 35/211 (16%)
Query: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706
Query: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
++ P I L + +K L R G I +A K
Sbjct: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822
Query: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPG 211
GNG ++ F D + + ++ + +PG
Sbjct: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPG 853
>gi|13129068 nucleolar complex associated 4 homolog [Homo sapiens]
Length = 516
Score = 29.3 bits (64), Expect = 5.4
Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 14/122 (11%)
Query: 26 ITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKW 85
+ F+ LE HP + KW F +E L L+ E ++ LL+ R YL+
Sbjct: 123 LKFVQLEGAHPLEKSKWEGNYLFPRELFKLVVGGLLSPEE--DQSLLLSQFREYLDYDDT 180
Query: 86 SF--------AVATIT----EIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGW 133
+ AVA +T E+PP + F + V P R T + + + W
Sbjct: 181 RYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVSLPRREPTVSSFYVKRAELWDTW 240
Query: 134 AI 135
+
Sbjct: 241 KV 242
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 29.3 bits (64), Expect = 5.4
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 121 TIMAGKLAVERGWAINVGGGF--HHCSSDRGGGFCAYADITLAIKFLFERVEG 171
T G L ++ INVGGG HC GGG A +A++ + RV G
Sbjct: 374 TCFGGSLGIQYEDKINVGGGLSGDHCKK-FGGGKTERARKAMAVEDIISRVRG 425
>gi|169234778 potassium channel tetramerisation domain containing 17
[Homo sapiens]
Length = 297
Score = 29.3 bits (64), Expect = 5.4
Identities = 27/121 (22%), Positives = 51/121 (42%), Gaps = 17/121 (14%)
Query: 38 DAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPP 97
D +G ++NFL+ KL+ D + E E + + + + + T+T++PP
Sbjct: 81 DPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPP 140
Query: 98 VIFLPNFLVQRKVLRPLRTQTGG-TIMAGKLAVERGW----AINVGGGFHHCSSDRGGGF 152
+ V R L+ Q T M ++ GW +N+G +++ S D+
Sbjct: 141 ----------KHVYRVLQCQEEELTQMVSTMS--DGWRFEQLVNIGSSYNYGSEDQAEFL 188
Query: 153 C 153
C
Sbjct: 189 C 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,163,822
Number of Sequences: 37866
Number of extensions: 577759
Number of successful extensions: 1442
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1380
Number of HSP's gapped (non-prelim): 32
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.