Search of human proteins with 216548385

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
         (1369 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                     2741   0.0  
gi|216548395 dachsous 2 isoform 3 [Homo sapiens]                     1373   0.0  
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                      1044   0.0  
gi|16933557 dachsous 1 precursor [Homo sapiens]                       807   0.0  
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            503   e-142
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           394   e-109
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      360   7e-99
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           357   4e-98
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            354   4e-97
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...   334   3e-91
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   333   5e-91
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...   326   1e-88
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 285   3e-76
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso...   284   4e-76
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs...   284   4e-76
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs...   277   4e-74
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs...   277   4e-74
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        277   6e-74
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        277   6e-74
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       271   4e-72
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       271   4e-72
gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precurs...   268   3e-71
gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precurs...   268   3e-71
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur...   264   4e-70
gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precur...   264   4e-70
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]        262   1e-69
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs...   261   2e-69
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs...   261   2e-69
gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precurs...   260   7e-69
gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precurs...   260   7e-69

>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score = 2741 bits (7105), Expect = 0.0
 Identities = 1369/1369 (100%), Positives = 1369/1369 (100%)

Query: 1    MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60
            MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS
Sbjct: 1    MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60

Query: 61   GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
            GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP
Sbjct: 61   GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120

Query: 121  DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180
            DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
Sbjct: 121  DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180

Query: 181  PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
            PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS
Sbjct: 181  PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240

Query: 241  SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
            SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE
Sbjct: 241  SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300

Query: 301  YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
            YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE
Sbjct: 301  YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360

Query: 361  LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
            LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE
Sbjct: 361  LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420

Query: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
            GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
Sbjct: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480

Query: 481  LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
            LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS
Sbjct: 481  LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540

Query: 541  QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
            QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA
Sbjct: 541  QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600

Query: 601  ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
            ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE
Sbjct: 601  ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660

Query: 661  PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH 720
            PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH
Sbjct: 661  PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH 720

Query: 721  DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
            DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI
Sbjct: 721  DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780

Query: 781  SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
            SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST
Sbjct: 781  SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840

Query: 841  TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA 900
            TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA
Sbjct: 841  TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA 900

Query: 901  REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960
            REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC
Sbjct: 901  REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960

Query: 961  SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS 1020
            SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS
Sbjct: 961  SSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS 1020

Query: 1021 PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP 1080
            PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP
Sbjct: 1021 PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP 1080

Query: 1081 SWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG 1140
            SWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG
Sbjct: 1081 SWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG 1140

Query: 1141 WIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV 1200
            WIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV
Sbjct: 1141 WIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV 1200

Query: 1201 EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHH 1260
            EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHH
Sbjct: 1201 EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHH 1260

Query: 1261 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
            EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV
Sbjct: 1261 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320

Query: 1321 FAKDPDEGNNAEVTYSVSSARPMPLKGKTAFGKQSCKKQTNKQTNKILT 1369
            FAKDPDEGNNAEVTYSVSSARPMPLKGKTAFGKQSCKKQTNKQTNKILT
Sbjct: 1321 FAKDPDEGNNAEVTYSVSSARPMPLKGKTAFGKQSCKKQTNKQTNKILT 1369


>gi|216548395 dachsous 2 isoform 3 [Homo sapiens]
          Length = 709

 Score = 1373 bits (3555), Expect = 0.0
 Identities = 684/688 (99%), Positives = 687/688 (99%)

Query: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60
           MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS
Sbjct: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60

Query: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
           GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP
Sbjct: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120

Query: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180
           DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
Sbjct: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180

Query: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
           PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS
Sbjct: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240

Query: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
           SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE
Sbjct: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
           LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420

Query: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
           GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480

Query: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
           LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540

Query: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
           QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA
Sbjct: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600

Query: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
           ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE
Sbjct: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660

Query: 661 PIFWRQVYNATIAEHAPVGHCFLQVTAS 688
           PIFWRQVYNATIAEHAPVGHCFLQ+ ++
Sbjct: 661 PIFWRQVYNATIAEHAPVGHCFLQLISA 688



 Score =  166 bits (419), Expect = 2e-40
 Identities = 180/579 (31%), Positives = 253/579 (43%), Gaps = 71/579 (12%)

Query: 252 RRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQP 311
           RRLDRE    +        G       ++ VE+RV D ND+ P F  D  +  V E + P
Sbjct: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182

Query: 312 GAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGG-------------GALGDAAYFA 357
           G       A D D G      Y+ V+   +P   +G                L   +   
Sbjct: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242

Query: 358 VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
           +E L  V+   R LDRE  A H+L +EA DGG       + V + VLD NDN P    +F
Sbjct: 243 LEPLDLVLL--RRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP----VF 296

Query: 418 LTEGGVARVSEGARPGDYVARVSVSDAD----GDWEKEDEATGELGVGLGDGSISLSLEG 473
             +   A V E A+PG  V RV  +D D    G       A    G G G G++     G
Sbjct: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL-----G 351

Query: 474 GEGDFAL--LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
               FA+  L G       + V  PLDRE++  ++L++ A D G+ P      + + V D
Sbjct: 352 DAAYFAVEELSG------VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405

Query: 532 LNDQPP----LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587
           +ND  P    LF  +   A VSE A PG  V  VS SDAD    D         +L    
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD---GDWEKEDEATGELGVGL 462

Query: 588 NLGSLQSKMVHTAECGPSFAIDSESGA--ISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
             GS+ S  +   E   +       G   +     LDRE ++  EL +VA D G PPLS 
Sbjct: 463 GDGSI-SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLST 521

Query: 646 TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD--SGLYGFIEYSLY 703
              + + V D+ND  P+F +Q Y A+++E A  G   + V+ASDAD     + ++ Y++ 
Sbjct: 522 EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581

Query: 704 D-------GFL------SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG- 749
                   G L      + E   +F ID   G I   + +DRE   A  +L V A+D G 
Sbjct: 582 QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQDLGE 640

Query: 750 -GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 787
             LSA   V + ++DVNDN P+F    Y  +I++    G
Sbjct: 641 PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679



 Score =  146 bits (368), Expect = 2e-34
 Identities = 157/561 (27%), Positives = 222/561 (39%), Gaps = 74/561 (13%)

Query: 497 LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556
           LDRE RD Y  +          L     + +RV D+ND  P F     +  VSE + PGT
Sbjct: 131 LDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184

Query: 557 VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-----GSLQSKMVHTAECGPSFAIDSE 611
                 A D D AG   +   YT+VQ   P +L     G        T    PS  +   
Sbjct: 185 AFRLPVAHDPD-AGL-FSTQGYTLVQ---PSDLPKDPAGPFFQLRYRTPGPLPSPLLPGS 239

Query: 612 SGAISTI-----RTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
           S  +  +     R LDRE   A  L++ A D G P  +    V + V D NDN P+F + 
Sbjct: 240 SSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQD 299

Query: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY--------DGFLSYEAPQAFRID 718
            Y A + E A  G    +V A+D D G  GF+ YS+          G  +      F ++
Sbjct: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359

Query: 719 PHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHP----VFN 772
              G + V + +DRE   A + L+VEA+DGG     A VRV +   DVNDN P    +F 
Sbjct: 360 ELSGVVRVWRPLDREAQ-AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418

Query: 773 PSTYVTSISDETQPGTEIINVLATDQDS------------GI---YGTVAYELIPGNVSS 817
               V  +S+  +PG  +  V  +D D             G+    G+++  L  G    
Sbjct: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478

Query: 818 LFTIDSTTGIIYLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
                   G+ +L +  PL         L++ A D G         + + +      P  
Sbjct: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538

Query: 876 FERPKYTFLVYEDVPEDSPIGTVKARE--------------------PLNSSEPIFYRIS 915
           F +  Y   V E     + +  V A +                    P N        + 
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598

Query: 916 SGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVND 974
           + + G  F+I    G I T + LD E Q  V L V AQ LG  P  ++  V+ITV DVND
Sbjct: 599 TAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658

Query: 975 NHPAFLRTSDEIRISQTTPPG 995
           N P F R      I++  P G
Sbjct: 659 NEPIFWRQVYNATIAEHAPVG 679



 Score =  110 bits (274), Expect = 1e-23
 Identities = 140/548 (25%), Positives = 219/548 (39%), Gaps = 93/548 (16%)

Query: 864  IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGD-- 918
            +H++    + +  +    T  V E +P D+ +G ++A  P    +     F    S D  
Sbjct: 52   VHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP 111

Query: 919  LGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978
            L   F +HP  G IRT + LD E +          LG+       +V I V DVND+ P 
Sbjct: 112  LLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-----VQVEIRVNDVNDHSPR 166

Query: 979  FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---------------- 1022
            F   S ++ +S+ +PPGTA  L  A D D+G      Y++  P                 
Sbjct: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226

Query: 1023 ----------PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071
                      PG  +    L ++ L   L   E     L + A D G   +  LL + + 
Sbjct: 227  TPGPLPSPLLPGSSSPLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSV- 1128
            V+++ ++ P   FE   Y+  V E   P  ++ + +A    LGP      +RYS+     
Sbjct: 286  VLDENDNPP--VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF---VRYSVRARQV 340

Query: 1129 -----------DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 1176
                       D+A F +   +G + + R  D E+   +   V A   + G    V+T  
Sbjct: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA--RDGGAEPEVATVR 398

Query: 1177 VIVRVWDENDNSPTFLHDVLFL------KVEESPVPQGVIGKITAIDMDSG--KNGQLLY 1228
            V + V D NDN P     VLFL      +V E   P   + +++  D D    K  +   
Sbjct: 399  VSIAVLDVNDNRPAI--HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456

Query: 1229 FL---LSDGKF----------FKMNPNTGELINWVA----LDREHRGHHEMTVLVTDRGS 1271
             L   L DG            F + P     + ++     LDRE R  +E+ ++ TD GS
Sbjct: 457  ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGS 516

Query: 1272 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE--GN 1329
            PP +    + + V D+ND  P F Q    +     V E      +V  V A D DE   +
Sbjct: 517  PPLSTEETLLLRVADLNDQPPLFSQ----QHYKASVSEAAAPGTVVMWVSASDADEAGSD 572

Query: 1330 NAEVTYSV 1337
            +A + Y+V
Sbjct: 573  HAWLRYTV 580



 Score =  104 bits (259), Expect = 7e-22
 Identities = 155/593 (26%), Positives = 235/593 (39%), Gaps = 112/593 (18%)

Query: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPS 774
            F + P  G I  ++ +DRER    Y  +        L A   V + + DVND+ P F   
Sbjct: 116  FHVHPDTGIIRTARRLDRERRDH-YSFVAATL----LGAVVQVEIRVNDVNDHSPRFPLD 170

Query: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI----------------------- 811
            +    +S+ + PGT     +A D D+G++ T  Y L+                       
Sbjct: 171  SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230

Query: 812  ------PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 865
                  PG+ S L  +D     + L   L   E+    L + A DGG         V + 
Sbjct: 231  LPSPLLPGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285

Query: 866  IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRI------SSGD 918
            +      P  FE+ +Y   V ED    + +  V+A +  L  +  + Y +       +G 
Sbjct: 286  VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGS 345

Query: 919  LGGK------FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVMD 971
             GG       F++    G +R  +PLD E Q    L V+A+ G A P  ++  V+I V+D
Sbjct: 346  GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405

Query: 972  VNDNHPA----FLRTSDEIRISQTTPPGTALYLARA-----------EDRDSGR------ 1010
            VNDN PA    FL      R+S+   PG   Y+AR            ED  +G       
Sbjct: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGD--YVARVSVSDADGDWEKEDEATGELGVGLG 463

Query: 1011 NGLIRYSIASPQPGVFAI--DRALGVLFL--NGSLGAGEQRELTLTLRAEDQGVHPQAAL 1066
            +G I  S+   + G FA+      GV FL   G L    +    L L A D G  P +  
Sbjct: 464  DGSISLSLEGGE-GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522

Query: 1067 LVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQML---QTQAHPLGPQRAASPLRY 1122
              L + V +  +  P ++ +H  Y+  VSE+ +P T ++    + A   G   A   LRY
Sbjct: 523  ETLLLRVADLNDQPPLFSQQH--YKASVSEAAAPGTVVMWVSASDADEAGSDHAW--LRY 578

Query: 1123 SLEP--------SVDSAM---------FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 1165
            ++          S+ S M         F I   +G I   R  D E  +    +V A   
Sbjct: 579  TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA--- 635

Query: 1166 EDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKV-EESPVPQGVIGKITA 1215
            +D     +S T +V +   D NDN P F   V    + E +PV    +  I+A
Sbjct: 636  QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688



 Score =  103 bits (256), Expect = 1e-21
 Identities = 123/480 (25%), Positives = 192/480 (40%), Gaps = 76/480 (15%)

Query: 876  FERPKYTFLVYEDVPED--SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933
            F    YT +   D+P+D   P   ++ R P     P+        L G  S    L  + 
Sbjct: 199  FSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL--------LPGSSSPLEPLDLVL 250

Query: 934  TRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTT 992
             R+ LD E      L ++A  G  P  +    V + V+D NDN P F +      + +  
Sbjct: 251  LRR-LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDA 309

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGV------------FAIDRALGVLFLNG 1039
             PG  +   RA DRD G NG +RYS+ + Q PG             FA++   GV+ +  
Sbjct: 310  QPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWR 369

Query: 1040 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE-----V 1093
             L    Q    L + A D G  P+ A + +++ V++  ++ P+    H+++  E     V
Sbjct: 370  PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA---IHVLFLTEGGVARV 426

Query: 1094 SESLSPMTQMLQTQAH--------------PLGPQRAASPLRYSLEPSV-DSAMF-GIRP 1137
            SE   P   + +                   LG       +  SLE    D A+  G  P
Sbjct: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486

Query: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST--TVIVRVWDENDNSPTFLHDV 1195
               ++ +    D ES   Y   + A    D     +ST  T+++RV D ND  P F    
Sbjct: 487  GVFFLCVEGPLDRESRDLYELLLVA---TDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543

Query: 1196 LFLKVEESPVPQGVIGKITAIDMD-SGKNGQLLYFLLSD--------------------G 1234
                V E+  P  V+  ++A D D +G +   L + +                      G
Sbjct: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603

Query: 1235 KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
              F ++  +G +     LDRE +   E+ V+  D G PP +AT  V ++V D+NDN P F
Sbjct: 604  PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score = 1044 bits (2699), Expect = 0.0
 Identities = 573/807 (71%), Positives = 601/807 (74%), Gaps = 94/807 (11%)

Query: 601  ECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQD----------LGEPPLSATCLV 649
            E   +F ID   G I   + +DRE   A  +L V A+D          L +  LSA   V
Sbjct: 104  EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFV 163

Query: 650  SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
             + ++DVNDN P+F    Y  +I++    G   + V A+D DSG+YG + Y L  G +S 
Sbjct: 164  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS- 222

Query: 710  EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
                 F ID   G                Y   VE       SA   V   LE      P
Sbjct: 223  ---SLFTIDSTTG---------------LYSPEVEILSAVNFSADKEVMNSLEMFL---P 261

Query: 770  VFNPSTYVTSISDETQP-------------GTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            +      V    +  +              G   ++ L    ++      A      N++
Sbjct: 262  LLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLA 321

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
             +       GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF
Sbjct: 322  KILG----EGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 377

Query: 877  ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 936
            ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK
Sbjct: 378  ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 437

Query: 937  PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT
Sbjct: 438  PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 497

Query: 997  ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE 1056
            ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE
Sbjct: 498  ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE 557

Query: 1057 DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 1116
            DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA
Sbjct: 558  DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 617

Query: 1117 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 1176
            ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT
Sbjct: 618  ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 677

Query: 1177 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 1236
            VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF
Sbjct: 678  VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 737

Query: 1237 FKMNPNT--------------------------------------------GELINWVAL 1252
            FKMNPNT                                            GELINWVAL
Sbjct: 738  FKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVAL 797

Query: 1253 DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 1312
            DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP
Sbjct: 798  DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 857

Query: 1313 VNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
            VNMLVTTVFAKDPDEGNNAEVTYSVSS
Sbjct: 858  VNMLVTTVFAKDPDEGNNAEVTYSVSS 884



 Score =  330 bits (845), Expect = 7e-90
 Identities = 358/1307 (27%), Positives = 544/1307 (41%), Gaps = 151/1307 (11%)

Query: 69   LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED-----SDDSPLLDDFHVHPDTG 123
            + +SV+E +P  TLV    A       ++  G FL+          +P  + F +HP  G
Sbjct: 1060 IVISVEENVPIGTLVYVFNA-------KDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112

Query: 124  IIRTARRLDRERRDHYSFVAATLLGAV---------VQVEIRVNDVNDHSPRFPLDSLQL 174
             + T  RLDRE              AV         +  +I + DVNDH+P F +     
Sbjct: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF-ISFPNA 1171

Query: 175  DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
             V E    G+      AHDPD G      Y+++  ++                       
Sbjct: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNE--------------------NMT 1211

Query: 235  LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP 294
             +   SS L    L     LD E    H L + A D G P  +   ++ + VLD ND  P
Sbjct: 1212 FMLDESSGL----LTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAP 1267

Query: 295  VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
            VF+Q  Y A+V+E+  PG  V RV A DRD G N  +++ +    +PGA           
Sbjct: 1268 VFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI----MPGA--------SFE 1315

Query: 355  YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
             F +   +G V     LDRE Q    L V  RDGG     +T  +   V D ND+ P   
Sbjct: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPE-- 1373

Query: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
              F+       V E   P + V  V  SD D    +  E    +  G  D   +++   G
Sbjct: 1374 --FIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEY--HIIDGNTDECFTINEMSG 1428

Query: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
            E               L     LDRE    + L+++ +D G PP S+   L +RV D ND
Sbjct: 1429 E---------------LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDAND 1473

Query: 535  QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
              P F   +Y++SV E A  GTVV+ +SA D DE  +                     Q+
Sbjct: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNG--------------------QT 1513

Query: 595  KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG-EPPLSATCLVSITV 653
            +   T E   +F ID  SG + T  TLDRE +       VA+D   +   S T ++ + V
Sbjct: 1514 EYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573

Query: 654  DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
             DVNDN+P+  +  ++  ++  +P     + V A D D G  G + +S        E   
Sbjct: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF------AETQS 1627

Query: 714  AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNP 773
             F ID + G+I   Q+   E  P    L V  +     +    + + +E   D    F+ 
Sbjct: 1628 MFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEG-EDVKISFSH 1686

Query: 774  STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
              Y   +++  + GT I+ V A   DS I  ++ Y +  GN   + ++ S +G + +  P
Sbjct: 1687 HLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEP 1745

Query: 834  --LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
              L       + L+V A+  G         V + I         FE+  Y   V E    
Sbjct: 1746 KFLDFEVRNEVQLIVLAESSGHRA---YCKVAVLIQDENDNSPCFEQSIYQASVSESQLY 1802

Query: 892  DSPIGTVKAREPLNS--SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
            ++ +  V A + L+S  +  I Y I SG+    F I    G I T+  LD+E      L 
Sbjct: 1803 NAHVIQVFATD-LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLI 1861

Query: 950  VQAQLGSAPACSSTEV-NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 1008
            VQA     P  S+T V  + V D+NDN PAFL  S+ + I++ + PG  +      D D 
Sbjct: 1862 VQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDL 1920

Query: 1009 GRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLV 1068
                +  ++  S     FAID+  GV+ L  +L   E  E  L ++  D   + + AL+V
Sbjct: 1921 NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVV 1980

Query: 1069 LTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSV 1128
               V++  ++ P   F    YQV V ES+     +L   A  L    +   + Y +  S 
Sbjct: 1981 R--VLDVNDNPP--VFSQDFYQVTVPESIPVGYSVLTLSATDL---ESNENISYRILSS- 2032

Query: 1129 DSAMFGIRPYTGWIY-LRRQFDYESTQTYNFRVFAWIPEDGFLQNVS--TTVIVRVWDEN 1185
             S  F I P  G I+ +      ++  T  F V A    DG   ++   T V + + D N
Sbjct: 2033 -SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEA---SDGGNPDLRALTLVEIGIEDMN 2088

Query: 1186 DNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD-SGKNGQLLYFLLS---------DGK 1235
            + +P F      L + E  +    +   + ID D + +N  + Y ++S         + K
Sbjct: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETK 2148

Query: 1236 FFKMN---PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 1292
            FF         G L+   +LDRE    HE+ +L +D G PP ++T  + + V D+NDN P
Sbjct: 2149 FFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP 2208

Query: 1293 FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             F         H  V E  P+   +T V A D D G++AE+ Y++ S
Sbjct: 2209 NFSSL----SYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS 2251



 Score =  323 bits (829), Expect = 5e-88
 Identities = 345/1280 (26%), Positives = 542/1280 (42%), Gaps = 166/1280 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
            F ++ DTG + T   LDRE ++ ++            L +   +   V D NDH+P F +
Sbjct: 1317 FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIV 1376

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
             S  ++V E   P   + + +A D DAG      Y ++  +          F +   +  
Sbjct: 1377 SSYDIEVLENQEPEVVYTV-LASDMDAGNNRAVEYHIIDGN------TDECFTINEMSG- 1428

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
                             +L   R LDRE+ +   L I   D G P R+ ++ +++RVLD 
Sbjct: 1429 -----------------ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDA 1471

Query: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
            ND+ P F    Y+++VREDA+ G  V  + A D+D G NG   Y +            GA
Sbjct: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-------TDEASGA 1524

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATVRVSIAVLDVND 408
                  F ++ +SG ++    LDREA++ H     ARD   +     TV + + V DVND
Sbjct: 1525 ------FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVND 1578

Query: 409  NRPAIHV----LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
            N P +      +FL+            P     + +V     D +     T         
Sbjct: 1579 NDPVLEQNPFDVFLS------------PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ 1626

Query: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
               S+    GE  F      P   +F     P+         L L  TD G P  +T   
Sbjct: 1627 SMFSIDKYTGEIQFQQ---NPSSEYF-----PI--------WLQLKVTDQGIPARTTTGL 1670

Query: 525  LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
            L++ +    D    FS   YK  V+E    GT ++ V A   D                 
Sbjct: 1671 LVIHMEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD----------------- 1712

Query: 585  APCNLGSLQSKMVHTAECGPS---FAIDSESGAISTI--RTLDREVQEAVELKVVAQDLG 639
                  S+Q  M ++   G      ++ S+SG ++    + LD EV+  V+L V+A+  G
Sbjct: 1713 ------SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG 1766

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
                 A C V++ + D NDN P F + +Y A+++E        +QV A+D DSGL G IE
Sbjct: 1767 H---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823

Query: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFV 757
            YS+  G       +AF+ID   G I     +D E   ++Y L+V+A D G   LS    +
Sbjct: 1824 YSILSG----NQEEAFQIDALSGVITTKAILDYELT-SSYSLIVQATDKGMPRLSNTTVI 1878

Query: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD--SGIYGTVAYELIPGNV 815
            +V + D+NDN P F PS  V  I++++ PG  + +V   D D  S    + A E  PG  
Sbjct: 1879 KVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPG-- 1935

Query: 816  SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
             + F ID  TG++ L   L   E T   L++   D    T      + + +      P  
Sbjct: 1936 -TKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYT---EGALVVRVLDVNDNPPV 1991

Query: 876  FERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTR 935
            F +  Y   V E +P    + T+ A + L S+E I YRI S     +FSI P+ GTI T 
Sbjct: 1992 FSQDFYQVTVPESIPVGYSVLTLSATD-LESNENISYRILSSSK--EFSIDPKNGTIFTI 2048

Query: 936  KP-LDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
             P L  +T       V+A  G  P   + T V I + D+N+  P F   S  + +S+   
Sbjct: 2049 SPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108

Query: 994  PGTALYLARAEDRDSGR-NGLIRYSIASPQP-GVFAID----------RALGVLFLNGSL 1041
             G+ L      D D  R N  + YSI S      F ++          + +G L L  SL
Sbjct: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168

Query: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPM 1100
                     L + A D G  P ++  V+++ V++  ++ P+  F  L Y   V ES +P+
Sbjct: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPN--FSSLSYHTHVKES-TPL 2225

Query: 1101 TQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
               +   +       + + + Y++    +   F +   TG +YL +  DYE    +   V
Sbjct: 2226 GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTV 2285

Query: 1161 FAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 1219
             A    D   ++ S  V+ V V D+ND++P F+       V E+      I  I A+D D
Sbjct: 2286 QA---SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD 2342

Query: 1220 SGKNGQLLYFLLS----------DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
            +G  G+L Y ++S          D   F ++P TG++     LD E+   + +TV   D+
Sbjct: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDK 2402

Query: 1270 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329
            G     A++ V+V +  I++  P F Q     +    + E      L+  V A D D G 
Sbjct: 2403 GDA--TASLVVWVDIEGIDEFEPIFTQ----DQYFFTLPEKNKDRQLIGRVEASDADAGI 2456

Query: 1330 NAEVTYSVSSARPMPLKGKT 1349
            +  + YS+ ++ P     KT
Sbjct: 2457 DGVILYSLGTSSPFFSVNKT 2476



 Score =  309 bits (791), Expect = 1e-83
 Identities = 246/684 (35%), Positives = 331/684 (48%), Gaps = 56/684 (8%)

Query: 684  QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 743
            +VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV
Sbjct: 78   EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 744  EAKDG------------GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791
            EAKDG            GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII
Sbjct: 138  EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197

Query: 792  NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDG 851
            NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG       L   E   LS +  + D 
Sbjct: 198  NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------LYSPEVEILSAVNFSADK 250

Query: 852  GGLTAVINADVTIHIFQTT-----LAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNS 906
              + ++      +  F+        A  +FE  +  F+ ++       +         + 
Sbjct: 251  EVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADG 310

Query: 907  SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEV 965
                 Y  +   + G+       G I    PL H     + L V AQ G    A  + +V
Sbjct: 311  EAAARYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADV 363

Query: 966  NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV 1025
             I +         F R      + +  P  + +   +A +  +    +     +    G 
Sbjct: 364  TIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGK 423

Query: 1026 FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 1085
            F+I   LG +     L    Q  + LT++A+       ++  V   V++  ++ P+  F 
Sbjct: 424  FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA--FL 481

Query: 1086 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 1145
                ++ +S++  P T +   +A      R    +RYS+  S    +F I    G ++L 
Sbjct: 482  RTSDEIRISQTTPPGTALYLARAEDRDSGRNGL-IRYSI-ASPQPGVFAIDRALGVLFLN 539

Query: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSP--TFLHDVLFLKVEES 1203
                    +     + A   + G     +  V+  V ++ ++SP  TF H V  ++V ES
Sbjct: 540  GSLGAGEQRELTLTLRA--EDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSES 597

Query: 1204 PVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKFFKMNPNTGELINWVALDREHRGHH 1260
              P   + +  A  +   +    L + L    D   F + P TG    W+ L R+     
Sbjct: 598  LSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG----WIYLRRQFDYES 653

Query: 1261 EMTVLVTDRGSPP-----RNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 1315
              T         P     +N +  V V V D NDN P F   +    L +KV E      
Sbjct: 654  TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV----LFLKVEESPVPQG 709

Query: 1316 LVTTVFAKDPDEGNNAEVTYSVSS 1339
            ++  + A D D G N ++ Y + S
Sbjct: 710  VIGKITAIDMDSGKNGQLLYFLLS 733



 Score =  293 bits (751), Expect = 6e-79
 Identities = 354/1364 (25%), Positives = 551/1364 (40%), Gaps = 172/1364 (12%)

Query: 52   VHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP 111
            +H++    + +  +    T  V E +P D+ +G ++A  P    +     F    S D  
Sbjct: 365  IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGD-- 419

Query: 112  LLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-----VQVEIRVNDVNDHSPR 166
            L   F +HP  G IRT + LD E +          LG+       +V I V DVND+ P 
Sbjct: 420  LGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 479

Query: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
            F   S ++ +S+ +PPGTA  L  A D D+G      Y++  P                 
Sbjct: 480  FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---------------- 523

Query: 227  TPGPLPSPLLPGSSSPLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
                      PG  +    L ++ L   L   E     L + A D G   +  LL + + 
Sbjct: 524  ----------PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 572

Query: 286  VLDENDNPP--VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPN---GFVRYSVRARQV 340
            V+++ ++ P   FE   Y+  V E   P  ++ + +A    LGP      +RYS+     
Sbjct: 573  VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSV- 629

Query: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA--RDGGAEPEVATVR 398
                       D+A F +   +G + + R  D E+   +   V A   + G    V+T  
Sbjct: 630  -----------DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 677

Query: 399  VSIAVLDVNDNRPAI--HVLFLTEGGVARVSEGARPGDYVARVSVSD------------- 443
            V + V D NDN P     VLFL      +V E   P   + +++  D             
Sbjct: 678  VIVRVWDENDNSPTFLHDVLFL------KVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731

Query: 444  -ADGDWEKEDEATGELG----VGLGDGSISLSLEGGEGDFA-----LLPGGPPGVFFLCV 493
             +DG + K +  TG  G    +   DG+ + S      DFA     L       +F    
Sbjct: 732  LSDGKFFKMNPNTGPAGTIYVITWADGAAAFS----GTDFAFSSDELQAFVLKSLFCELG 787

Query: 494  EG------PLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ----QH 543
            EG       LDRE R  +E+ ++ TD GSPP +    + + V D+ND  P F Q    + 
Sbjct: 788  EGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 847

Query: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
                V E      +V  V A D DE   ++A + Y+                 V + +  
Sbjct: 848  LHVKVLEGQPVNMLVTTVFAKDPDE--GNNAEVTYS-----------------VSSEDSS 888

Query: 604  PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
              F ID+ +G I T   L  + + +  + V+A D G PPL    +V+I V  ++    I 
Sbjct: 889  DHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIM 948

Query: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723
             + + +  I E+         + +SD    L       L+   ++ +    F ID   G 
Sbjct: 949  SQNIRHLIIPENLKPTKIMSLIKSSD---HLQQHYNGKLHFSIVADDKDGHFEIDSSTGD 1005

Query: 724  ICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
            + +S+++D E   + Y   V   D      LS+  F+ +D+ED ND+ P F     V S+
Sbjct: 1006 LFLSKELDYE-TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064

Query: 781  SDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNV-SSLFTIDSTTGIIYLTLPLSHLE 838
             +    GT +    A D D S +   + Y +   N  ++ F I  + G +     L    
Sbjct: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124

Query: 839  STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL------VYEDVPED 892
              T+ L V+A D     AV   D  +      +   +      TF+      V EDV   
Sbjct: 1125 IPTVILTVTASD----QAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVG 1180

Query: 893  SPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
            S +  + A +P    +  + Y I SG+    F +    G + T  PLD+E +   +LTV 
Sbjct: 1181 SLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVL 1240

Query: 952  AQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
            A     PA SS++ + +TV+DVND  P F +   E  + +   PG  +    A DRDSG 
Sbjct: 1241 ALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGV 1300

Query: 1011 NGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP-QAA 1065
            N  +++ I    PG    +F I+   G +     L    Q   TL +   D G     + 
Sbjct: 1301 NSKLQFEI---MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357

Query: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP-MTQMLQTQAHPLGPQRAASPLRYSL 1124
              +L  V ++ +H+P +      Y +EV E+  P +   +       G  RA   + Y +
Sbjct: 1358 TTILCTVEDENDHAPEFIVSS--YDIEVLENQEPEVVYTVLASDMDAGNNRA---VEYHI 1412

Query: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWD 1183
                    F I   +G +   R  D E  Q  NF +     + G     S   + VRV D
Sbjct: 1413 IDGNTDECFTINEMSGELSTTRALDRE--QISNFTLVILCSDLGDPPRSSVIHLQVRVLD 1470

Query: 1184 ENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK-FFKMNPN 1242
             ND+SP+F        V E      V+  ++A+D D G NGQ  YFL  +    F ++P 
Sbjct: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPM 1530

Query: 1243 TGELINWVALDREHRGHHEMTVLVTD---RGSPPRNATMAVYVSVTDINDNRPFFPQCLP 1299
            +G L     LDRE R  H  + +  D   +GS  R+ T+ + V VTD+NDN P   Q   
Sbjct: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVNDNDPVLEQ--- 1585

Query: 1300 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
                 V +    P N     V A D D G N  V +S +  + M
Sbjct: 1586 -NPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM 1628



 Score =  292 bits (748), Expect = 1e-78
 Identities = 319/1213 (26%), Positives = 503/1213 (41%), Gaps = 138/1213 (11%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVA-ATLLG-----AVVQVEIRVNDVNDHSPRFPL 169
            F ++  +G + T R LDRE+  +++ V   + LG     +V+ +++RV D NDHSP FP 
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
               Q  V E +  GT   +  A D D GL     Y L        + +G F      T  
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD------EASGAF------TID 1528

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG-RPRRTGLLSVELRVLD 288
            P+   L   ++             LDRE  + H     A D   +  R+  + +++ V D
Sbjct: 1529 PMSGTLKTSNT-------------LDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTD 1575

Query: 289  ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
             NDN PV EQ+ +   +  ++        VRA D DLGPNG V +S    Q         
Sbjct: 1576 VNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ--------- 1626

Query: 349  ALGDAAYFAVEELSGVVRVWR-PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
                 + F++++ +G ++  + P       W QL V   D G        R +  +L ++
Sbjct: 1627 -----SMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVT--DQGIP-----ARTTTGLLVIH 1674

Query: 408  DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
                 + + F        V+E    G  +  V     D     +D     +  G  DG +
Sbjct: 1675 MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSI---QDSMKYSIFSGNEDGVL 1731

Query: 468  SLSLEGGEGDFALLPGGPPGVFFLCVEGP--LDRESRDLYELLLVATDAGSPPLSTEETL 525
            SL  + G+               L V+ P  LD E R+  +L+++A  +G         L
Sbjct: 1732 SLCSKSGQ---------------LTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL 1776

Query: 526  LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
               + D ND  P F Q  Y+ASVSE+      V+ V A+D D                  
Sbjct: 1777 ---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSG---------------- 1817

Query: 586  PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
               L  L    + +     +F ID+ SG I+T   LD E+  +  L V A D G P LS 
Sbjct: 1818 ---LNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874

Query: 646  TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
            T ++ + V D+NDN P F        I E +  G     V+  D D      +  +    
Sbjct: 1875 TTVIKVQVTDINDNAPAFLPSEA-VEITEDSLPGVIVTHVSVHDVD------LNSAFIFS 1927

Query: 706  FLSYEAPQA-FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
            F     P   F ID + G + + + +D E +   Y+LL++  D    +  A V V + DV
Sbjct: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYTEGALV-VRVLDV 1985

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
            NDN PVF+   Y  ++ +    G  ++ + ATD +S     ++Y ++    S  F+ID  
Sbjct: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN--ENISYRILSS--SKEFSIDPK 2041

Query: 825  TGIIYLTLPLSHLES-TTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
             G I+   P+  L++ +T   +V A DGG         V I I        EF    Y  
Sbjct: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101

Query: 884  LVYEDVPEDSPIGTVKAREPLNSSEPIF--YRISSGDLGGKFSI----------HPRLGT 931
             + ED    S + T    +   + E  +  Y I SG+    F +          + ++G 
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161

Query: 932  IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEV-NITVMDVNDNHPAFLRTSDEIRISQ 990
            +     LD E      L + A     P  SST V +I V+DVNDN P F   S    + +
Sbjct: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQREL 1049
            +TP G+ + +  A DRD+G +  I Y+I S  + G F ++   GVL+L   L   +  + 
Sbjct: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKF 2281

Query: 1050 TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
            TLT++A D      +  +V   V++  +H+P + F      V  +  +S     +     
Sbjct: 2282 TLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341

Query: 1110 PLGPQ-----RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
              GP         SP   +   S D  +F I P TG I+ ++  DYE+   Y   V A  
Sbjct: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401

Query: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
              D      S  V V +   ++  P F  D  F  + E    + +IG++ A D D+G +G
Sbjct: 2402 KGDA---TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDG 2458

Query: 1225 QLLYFLLSDGKFFKMNPNTGE--LINWVALDREHRGHH---EMTVLVTDRGSPPRNATMA 1279
             +LY L +   FF +N   G   LI  + L +         EM ++     S  + A+  
Sbjct: 2459 VILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCT 2518

Query: 1280 VYVSVTDINDNRP 1292
            V+V+V+  ++  P
Sbjct: 2519 VFVNVSFSSEGTP 2531



 Score =  262 bits (670), Expect = 1e-69
 Identities = 322/1307 (24%), Positives = 515/1307 (39%), Gaps = 174/1307 (13%)

Query: 80   DTLVGDIRAGLPAAQQQEGSG-----FFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE 134
            D  VG +   + A    EG         LS + + + +LD+      +G++ T   LD E
Sbjct: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDE-----SSGLLTTTCPLDYE 1230

Query: 135  RRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRL 188
             +  +      L      L +   + + V DVND +P F     +  V E   PG     
Sbjct: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290

Query: 189  PVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL-- 246
              A D D+G+ S                              L   ++PG+S  L  +  
Sbjct: 1291 VEALDRDSGVNSK-----------------------------LQFEIMPGASFELFEINS 1321

Query: 247  ---DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
               ++V    LDRE      L++   DGG P  +   ++   V DEND+ P F    Y  
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDI 1381

Query: 304  AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
             V E+ +P   V  V A+D D G N  V Y +    + G             F + E+SG
Sbjct: 1382 EVLENQEPEV-VYTVLASDMDAGNNRAVEYHI----IDG--------NTDECFTINEMSG 1428

Query: 364  VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGV 423
             +   R LDRE  +   LV+   D G  P  + + + + VLD ND+ P+   L+      
Sbjct: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSS-- 1486

Query: 424  ARVSEGARPGDYVARVSVSDADG------DWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
              V E A  G  V  +S  D D       ++   DEA+G   +    G++  S       
Sbjct: 1487 --VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTS------- 1537

Query: 478  FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG-SPPLSTEETLLLRVADLNDQP 536
                               LDRE+R  +    VA D       ST   + + V D+ND  
Sbjct: 1538 -----------------NTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDND 1580

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P+  Q  +   +S  +      + V A D D                     LG   + +
Sbjct: 1581 PVLEQNPFDVFLSPESPTNQTTVIVRADDLD---------------------LGPNGTVV 1619

Query: 597  VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
               AE    F+ID  +G I   +    E    + L++   D G P  + T L+ I ++  
Sbjct: 1620 FSFAETQSMFSIDKYTGEIQFQQNPSSEYFP-IWLQLKVTDQGIPARTTTGLLVIHMEG- 1677

Query: 657  NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
             D +  F   +Y   + E+   G   + V A   DS +   ++YS++ G           
Sbjct: 1678 EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSG----NEDGVLS 1732

Query: 717  IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTY 776
            +    GQ+ V +    + +      L+   +  G  A   V V ++D NDN P F  S Y
Sbjct: 1733 LCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIY 1792

Query: 777  VTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSH 836
              S+S+       +I V ATD DSG+ G + Y ++ GN    F ID+ +G+I     L +
Sbjct: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852

Query: 837  LESTTLSLMVSAQDGG----GLTAVINADVT-IHIFQTTLAPAEFERPKYTFLVYEDVPE 891
              +++ SL+V A D G      T VI   VT I+       P+E            ++ E
Sbjct: 1853 ELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE----------AVEITE 1902

Query: 892  DSPIGTVKAREPLN----SSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 947
            DS  G +     ++    +S  IF      + G KF+I    G +   K LD E      
Sbjct: 1903 DSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYE 1962

Query: 948  LTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 1007
            L +  Q+  +   +   + + V+DVNDN P F +   ++ + ++ P G ++    A D +
Sbjct: 1963 LLI--QISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE 2020

Query: 1008 SGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP--QAA 1065
            S  N  I Y I S     F+ID   G +F    +   +    T  L     G +P  +A 
Sbjct: 2021 SNEN--ISYRILSSSK-EFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRAL 2077

Query: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 1125
             LV   + +   ++P +T +   Y + +SE     + ++          R  + + YS+ 
Sbjct: 2078 TLVEIGIEDMNNYAPEFTVKS--YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135

Query: 1126 PSVDSAMFGIR--------PY--TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 1175
                   F +         PY   G++ L    D E++ ++   + A   + G     ST
Sbjct: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILA--SDSGCPPLSST 2193

Query: 1176 TVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG 1234
             VI ++V D NDN P F        V+ES      I  ++A D D+G + +++Y ++S  
Sbjct: 2194 AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGN 2253

Query: 1235 K--FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP 1292
            +   F +  NTG L     LD E      +TV  +D       +   V+VSV D ND+ P
Sbjct: 2254 EKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVLDDNDHAP 2312

Query: 1293 FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             F            V E  P++  + ++ A D D G   E+TYS+ S
Sbjct: 2313 QF----MFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355



 Score =  221 bits (564), Expect = 3e-57
 Identities = 288/1203 (23%), Positives = 462/1203 (38%), Gaps = 175/1203 (14%)

Query: 254  LDRE-EAAAHRLQIEAWDGGRPRRTGLLSVE----------LRVLDENDNPPVFEQDEYR 302
            +DRE + A + L +EA DG   R T L  V+          + + D NDN PVF    Y 
Sbjct: 124  IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183

Query: 303  AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             ++ ++ QPG E+  V ATD+D G  G V Y +    +PG  S        + F ++  +
Sbjct: 184  TSISDETQPGTEIINVLATDQDSGIYGTVAYEL----IPGNVS--------SLFTIDSTT 231

Query: 363  GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVA-TVRVSIAVL----DVNDNRPAIHVLF 417
            G+         E +     ++ A +  A+ EV  ++ + + +L     V  +  A    F
Sbjct: 232  GLY------SPEVE-----ILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKF 280

Query: 418  LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
                G     +G R   Y+ +V    A  D E        L   LG+G I L+L      
Sbjct: 281  EASRGWFMRFKGRRHLHYL-KVQDEAASADGEAAARYVANLAKILGEGIIYLTL------ 333

Query: 478  FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                              PL         L++ A D G         + + +      P 
Sbjct: 334  ------------------PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 375

Query: 538  LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
             F +  Y   V E     + +  V A +                    P N        +
Sbjct: 376  EFERPKYTFLVYEDVPEDSPIGTVKARE--------------------PLNSSEPIFYRI 415

Query: 598  HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
             + + G  F+I    G I T + LD E Q  V L V AQ LG  P  ++  V+ITV DVN
Sbjct: 416  SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVN 474

Query: 658  DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
            DN P F R      I++  P G       A D DSG  G I YS+     +   P  F I
Sbjct: 475  DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-----ASPQPGVFAI 529

Query: 718  DPHDGQICVSQDIDR-ERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP--VFNPS 774
            D   G + ++  +   E+   T  L  E +     +A   + V +E   ++ P   F   
Sbjct: 530  DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHL 588

Query: 775  TYVTSISDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
             Y   +S+   P T+++   A           + Y L P   S++F I   TG IYL   
Sbjct: 589  VYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQ 648

Query: 834  LSHLESTTLSLMVSAQ-DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED 892
              +  + T +  V A     G    ++  V + ++        F        V E     
Sbjct: 649  FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQ 708

Query: 893  SPIGTVKA--REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL------------ 938
              IG + A   +   + + +++ +S G     F ++P  G   T   +            
Sbjct: 709  GVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGPAGTIYVITWADGAAAFSGT 765

Query: 939  -----DHETQPVVVLTVQAQLG----------------------------SAPACSSTEV 965
                   E Q  V+ ++  +LG                            S P  ++  V
Sbjct: 766  DFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 825

Query: 966  NITVMDVNDNHPAFLRTSD----EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
             ++V D+NDN P F +        +++ +  P    +    A+D D G N  + YS++S 
Sbjct: 826  YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSE 885

Query: 1022 QPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP---QAALLVLTVVIEKRE 1077
                 F ID   G +     L    +    +++ A DQGV P   QA + +  + + K  
Sbjct: 886  DSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGR 945

Query: 1078 HSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRP 1137
               S    HL+    + E+L P   M   ++     Q     L +S+        F I  
Sbjct: 946  AIMSQNIRHLI----IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDS 1001

Query: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF 1197
             TG ++L ++ DYE+T  Y FRV           + +  + + V D+ND+SP+F  +++ 
Sbjct: 1002 STGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIV 1061

Query: 1198 LKVEESPVPQGVIGKITAIDMDSGK--NGQLLYFLLSDG---KFFKMNPNTGELINWVAL 1252
            + VEE+ VP G +  +     D G   N ++ Y++ S       F ++P+ G L+    L
Sbjct: 1062 ISVEEN-VPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRL 1120

Query: 1253 DREHRGHHEMTVLVTDRG---SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE 1309
            DRE      +TV  +D+    +  R  ++   + + D+ND+ P F   +     HVK  E
Sbjct: 1121 DRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF---ISFPNAHVK--E 1175

Query: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSAR---PMPLKGKTAFGKQSCKKQTNKQTNK 1366
               V  LV  + A DPDEG N +VTYS+ S        L   +     +C      +T  
Sbjct: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235

Query: 1367 ILT 1369
            ILT
Sbjct: 1236 ILT 1238



 Score =  179 bits (453), Expect = 2e-44
 Identities = 293/1282 (22%), Positives = 486/1282 (37%), Gaps = 192/1282 (14%)

Query: 132  DRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191
            D +R  H + V   L  A   V + + DVND+ P F   +    +S+ + PGT     +A
Sbjct: 143  DEQRMTHLALVKGGL-SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLA 201

Query: 192  HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVL- 250
             D D+G++ T  Y L+  +            L       L +         +  L++ L 
Sbjct: 202  TDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLP 261

Query: 251  ----LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE-LRVLDENDNPPVFEQDEYRAAV 305
                 ++++R+E AA + + EA  G   R  G   +  L+V DE              A 
Sbjct: 262  LLRHFKKVERDEEAAEK-KFEASRGWFMRFKGRRHLHYLKVQDE--------------AA 306

Query: 306  REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
              D +  A                  RY     ++ G G                   ++
Sbjct: 307  SADGEAAA------------------RYVANLAKILGEG-------------------II 329

Query: 366  RVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD-----VNDNRPAIHVLFLTE 420
             +  PL         L+V A+DGG    V    V+I +           RP    L   +
Sbjct: 330  YLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 389

Query: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
                 V E +  G   AR  ++ ++  + +   ++G+LG                G F++
Sbjct: 390  -----VPEDSPIGTVKAREPLNSSEPIFYR--ISSGDLG----------------GKFSI 426

Query: 481  LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
                 P +  +    PLD E++ +  +L V    GS P  +   + + V D+ND  P F 
Sbjct: 427  ----HPRLGTIRTRKPLDHETQPVV-VLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL 481

Query: 541  QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
            +   +  +S+   PGT +    A D D     +  +RY++                    
Sbjct: 482  RTSDEIRISQTTPPGTALYLARAEDRD--SGRNGLIRYSIASPQPGV------------- 526

Query: 601  ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
                 FAID   G +    +L    Q  + L + A+D G  P +A  ++++ ++   ++ 
Sbjct: 527  -----FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHS 580

Query: 661  P--IFWRQVYNATIAEHAPVGHCFLQVTASD-ADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
            P   F   VY   ++E        LQ  A           + YSL     S      F I
Sbjct: 581  PSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS----AMFGI 636

Query: 718  DPHDGQICVSQDIDRERDPATYDLLVEA---KDGGGLSAQAFVRVDLEDVNDNHPVFNPS 774
             P+ G I + +  D E    TY+  V A   +DG   +    V V + D NDN P F   
Sbjct: 637  RPYTGWIYLRRQFDYE-STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHD 695

Query: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGIIYL--- 830
                 + +   P   I  + A D DSG  G + Y L+  G    +       G IY+   
Sbjct: 696  VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITW 755

Query: 831  ------------TLPLSHLESTTLSLMVSAQDGGGLT--AVINADVTIHIFQTTLAPAEF 876
                              L++  L  +      G L     ++ +   H   T L     
Sbjct: 756  ADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRG 815

Query: 877  ERPK-YTFLVYEDV---------------------------PEDSPIGTVKAREP-LNSS 907
              P+  T  VY  V                           P +  + TV A++P   ++
Sbjct: 816  SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875

Query: 908  EPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVN 966
              + Y +SS D    F I    G IRT   L ++ +P   ++V A   G  P      VN
Sbjct: 876  AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVN 935

Query: 967  ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR-DSGRNGLIRYSI-ASPQPG 1024
            I V+ ++       +    + I +   P   + L ++ D      NG + +SI A  + G
Sbjct: 936  IQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG 995

Query: 1025 VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLVLTVVIE-KREHSPSW 1082
             F ID + G LFL+  L           +   D   +   ++ + L++ +E + +HSPS+
Sbjct: 996  HFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055

Query: 1083 TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP-SVDSAMFGIRPYTGW 1141
              E +V  VE  E++   T +    A         S ++Y +E  +  +  F I P  G 
Sbjct: 1056 QDELIVISVE--ENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGT 1113

Query: 1142 IYLRRQFDYESTQTYNFRVFAWIP----EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF 1197
            +    + D ES  T    V A        D  L++++  ++  + D ND++PTF+     
Sbjct: 1114 LVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIV--ILDVNDHNPTFI-SFPN 1170

Query: 1198 LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDRE 1255
              V+E      ++  ITA D D G+NG++ Y +LS  +   F ++ ++G L     LD E
Sbjct: 1171 AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE 1230

Query: 1256 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 1315
             +  H +TVL  D G+P  +++  + V+V D+ND  P F Q L        V E Q    
Sbjct: 1231 MKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL----YEASVKENQNPGE 1286

Query: 1316 LVTTVFAKDPDEGNNAEVTYSV 1337
             VT V A D D G N+++ + +
Sbjct: 1287 FVTRVEALDRDSGVNSKLQFEI 1308



 Score =  112 bits (279), Expect = 3e-24
 Identities = 132/522 (25%), Positives = 215/522 (41%), Gaps = 69/522 (13%)

Query: 147  LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTL 206
            L A+  VEI + D+N+++P F + S  L +SE +  G+        D D     T+  T 
Sbjct: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDW----TRENTY 2129

Query: 207  VQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLD-LVLLRRLDREEAAAHRLQ 265
            V+ S +  +    F                  S  P + +  LVLL  LDRE +A+H L 
Sbjct: 2130 VEYSIISGNSQNNFHV----------ETKFFHSEYPYKQVGYLVLLHSLDREASASHELV 2179

Query: 266  IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDL 325
            I A D G P  +    + ++VLD NDNPP F    Y   V+E    G+ +  V A DRD 
Sbjct: 2180 ILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT 2239

Query: 326  GPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA 385
            G +  + Y++ +    G            +F +EE +GV+ + +PLD E      L V+A
Sbjct: 2240 GSHAEIIYNIISGNEKG------------HFYLEENTGVLYLIKPLDYEKMTKFTLTVQA 2287

Query: 386  RDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD 445
             D   +   +   V ++VLD ND+ P     F+       V E       +  ++  D D
Sbjct: 2288 SDA-EKKHFSFAVVFVSVLDDNDHAPQ----FMFSSFSCIVPENLPISSTICSINALDFD 2342

Query: 446  GDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLY 505
                      GEL   +            + D  L+    P    +  +  LD E+ + Y
Sbjct: 2343 AG------PYGELTYSIVSPCFLTHGMSYDHDLFLID---PLTGDIHAKQILDYENGNKY 2393

Query: 506  ELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASD 565
             L + A D G    S    + + +  +++  P+F+Q  Y  ++ E      ++  V ASD
Sbjct: 2394 CLTVQAKDKGDATASL--VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASD 2451

Query: 566  ADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL---- 621
            AD AG D   L           +LG+            P F+++  +G I  IR L    
Sbjct: 2452 AD-AGIDGVILY----------SLGT----------SSPFFSVNKTNGNIYLIRALPLIK 2490

Query: 622  -DREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPI 662
                 ++ +E+K++A         A+C V + V   ++  P+
Sbjct: 2491 SQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPL 2532



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/150 (29%), Positives = 69/150 (46%), Gaps = 24/150 (16%)

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+A+P  E   V A+D D G  GF+ YS+          G  +      F ++   G + 
Sbjct: 69  ENAKPVKET-EVTASDADSGLYGFIEYSLY--------DGFLSYEAPQAFRIDPHDGQIC 119

Query: 367 VWRPLDREAQ-AWHQLVVEARDGGAE--PEVATVR--------VSIAVLDVNDNRPAIHV 415
           V + +DRE   A + L+VEA+DG  +    +A V+        V + + DVNDN P    
Sbjct: 120 VSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHP---- 175

Query: 416 LFLTEGGVARVSEGARPGDYVARVSVSDAD 445
           +F     V  +S+  +PG  +  V  +D D
Sbjct: 176 VFNPSTYVTSISDETQPGTEIINVLATDQD 205



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 40/161 (24%)

Query: 491 LCVEGPLDRESRD--LYELLLVATDAGSPP----------LSTEETLLLRVADLNDQPPL 538
           +CV   +DRE RD   Y+LL+ A D               LS +  + + + D+ND  P+
Sbjct: 118 ICVSQDIDRE-RDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPV 176

Query: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
           F+   Y  S+S+   PGT ++ V A+D D        +  TV     P N+ SL      
Sbjct: 177 FNPSTYVTSISDETQPGTEIINVLATDQDSG------IYGTVAYELIPGNVSSL------ 224

Query: 599 TAECGPSFAIDSESG-------AISTIR-TLDREVQEAVEL 631
                  F IDS +G        +S +  + D+EV  ++E+
Sbjct: 225 -------FTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEM 258



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 28/163 (17%)

Query: 1195 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG-------KFFKMNPNTGELI 1247
            ++F   EE+  P     ++TA D DSG  G + Y L  DG       + F+++P+ G++ 
Sbjct: 62   IVFRSQEENAKPVKET-EVTASDADSGLYGFIEYSLY-DGFLSYEAPQAFRIDPHDGQIC 119

Query: 1248 NWVALDREHR-------------GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
                +DRE                   MT L   +G    +A   V V + D+NDN P F
Sbjct: 120  VSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVF 177

Query: 1295 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
                P   +     E QP   ++  V A D D G    V Y +
Sbjct: 178  N---PSTYVTSISDETQPGTEII-NVLATDQDSGIYGTVAYEL 216


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  807 bits (2085), Expect = 0.0
 Identities = 506/1305 (38%), Positives = 714/1305 (54%), Gaps = 85/1305 (6%)

Query: 47   LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
            LL LL+ +      G+  Q  +L L +DE  P  TL+GDI AGLPA        F  +++
Sbjct: 25   LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQE 84

Query: 107  SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPR 166
               S +  D  +   +G++RTAR LDRE+RD Y F A T  GA V+V +RV D+NDH+P 
Sbjct: 85   G--SGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPA 142

Query: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
            FP     L V E +  GT + L  A D DAG   TQGY L        D AG  F+L  R
Sbjct: 143  FPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL------SGDGAGETFRLETR 196

Query: 227  TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
             PGP  +P+           +LV+   LDRE  + + LQ+EA+DGG P R     +++ +
Sbjct: 197  -PGPDGTPVP----------ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTL 245

Query: 287  LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
            LD ND+ P F Q  Y A V E   PG+ V +V A+D D G NG V Y +  RQ  G G  
Sbjct: 246  LDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP- 304

Query: 347  GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
                     F+++  +G++++ RPLD E +  H+LVV+ARDGGA PE+ +  V++ V D 
Sbjct: 305  ---------FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355

Query: 407  NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD-GDWEKEDEATGELGVGLGDG 465
            NDN+P++ V+FL+  G  +VSE A PG  VAR+SVSD D GD+                 
Sbjct: 356  NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF----------------A 399

Query: 466  SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
             +++SLEGGEG FAL       ++ +CV   LDRE RD Y L + ATD+GSPPL  E   
Sbjct: 400  HVNVSLEGGEGHFALSTQDSV-IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF 458

Query: 526  LLRVADLNDQPPLFSQQHYKAS-VSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
            +L V D+ND  P F +Q Y+   + E A PG+ V+ V+A D D+  +        V    
Sbjct: 459  VLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ------VTYSL 512

Query: 585  APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
            AP           HT      F+ID  SG I+T  +LD E++   +L VVA D G PPL+
Sbjct: 513  APG---------AHTHW----FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559

Query: 645  ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
            ++  VS+ + DVNDNEP F R  YNA++ E    G CFLQVTA+DADSG +G + YSL  
Sbjct: 560  SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619

Query: 705  GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
            G  S  +P  FRID H G +C ++ +DR++ P+++D  V A DGGGL +  +V+V L D 
Sbjct: 620  GLGSSGSPP-FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDE 678

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
            NDN P F P  Y  SIS ++ PGT ++ + A D D G +G ++Y ++ GN   LFT+D  
Sbjct: 679  NDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQ 738

Query: 825  TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
            +G++ +  PL+   ++ + L + A+DGGGL A  +A V I I   T  P  FE+ +Y F 
Sbjct: 739  SGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFS 798

Query: 885  VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE-TQ 943
            V EDV   + +G V+A  P     P+   +S GD  G FS+    G ++T +PLD E   
Sbjct: 799  VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858

Query: 944  PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003
            PV+ L V+A  G  PA +   V + + DVNDN PAF    D + +   T PGT +Y  RA
Sbjct: 859  PVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRA 918

Query: 1004 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
             D DSG N  + +++ +   G F +D   G + L   LG        L L A D G  P+
Sbjct: 919  LDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR 978

Query: 1064 AALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 1120
             +   L VV++    R  +P   F    Y+V++    +  TQ+LQ QA    P     P+
Sbjct: 979  TSHFRLRVVVQDVGTRGLAP--RFNSPTYRVDLPSGTTAGTQVLQVQAQ--APD--GGPI 1032

Query: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVI 1178
             Y L     S+ FG+ P +GW+++R   D E+ + Y  +V A       L  Q  + TV 
Sbjct: 1033 TYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVR 1092

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF---LLSDGK 1235
            V + ++N++SP    D  FL V E+  P   +G++ A D DSG NG+L Y    L  D K
Sbjct: 1093 VSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSK 1152

Query: 1236 FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFP 1295
             F+++P TGE+     LDRE +  +++ V V D GSPPR+ T  V+V+V D+NDN P F 
Sbjct: 1153 AFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFL 1212

Query: 1296 QC--LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
            Q     G  L ++V +  P   LVTT+ AKDPDEG N  + Y+++
Sbjct: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT 1257



 Score =  428 bits (1100), Expect = e-119
 Identities = 394/1300 (30%), Positives = 569/1300 (43%), Gaps = 141/1300 (10%)

Query: 69   LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
            LT++  EGL P +L+G + A  PA             D + +  LD       +G +  A
Sbjct: 1337 LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALD-----AASGRLYLA 1391

Query: 129  RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
            R LD E    +  +     G       +++V+++V D N+H+P F  D L L + E   P
Sbjct: 1392 RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEP 1451

Query: 183  GTAFRLPVAHDPDA-GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G A     A D D  G  S   Y L++     ++P  P  +L  RT G L +P       
Sbjct: 1452 GAALYTFRASDADGPGPNSDVRYRLLR-----QEPPVPALRLDART-GALSAP------- 1498

Query: 242  PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-----RRTGLLSVELRVLDENDNPPVF 296
                      R LDRE   A  L +EA D  RP     RR   +S  + V DENDN PVF
Sbjct: 1499 ----------RGLDRETTPALLLLVEATD--RPANASRRRAARVSARVFVTDENDNAPVF 1546

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
                 R  + ED  PG     V A D DLG    V Y +             A G   +F
Sbjct: 1547 ASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL-------------ASGGDGHF 1592

Query: 357  AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
             +   +G + V RPLDRE +A H L V A D G+ P  AT  ++++V DVND  P     
Sbjct: 1593 RLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT---- 1648

Query: 417  FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
            F  +     + E   PG  +  +  +D D        A G++  G G  S S SL+   G
Sbjct: 1649 FQQQEYSVLLRENNPPGTSLLTLRATDPDVG------ANGQVTYG-GVSSESFSLDPDTG 1701

Query: 477  DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                L               LDRE ++   L + A D GSPP  T  T+ + V D ND  
Sbjct: 1702 VLTTLRA-------------LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHA 1748

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P F   H    V E   P T+ M + ASD D   +                  G LQ ++
Sbjct: 1749 PTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGAN------------------GQLQYRI 1789

Query: 597  VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
            +     G +F +D  SG   T+R LDREV+ A +L++ A+D G+P LSAT L+++TV D 
Sbjct: 1790 LDGDPSG-AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDA 1848

Query: 657  NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
            ND+ P F    Y+  + E  P G   LQ+ A D D+G  G + Y     +L      AF 
Sbjct: 1849 NDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY-----YLGAGTAGAFL 1903

Query: 717  IDPHDGQICVSQDIDRERDPATYDLLVEAKDG---GGLSAQAFVRVDLEDVNDNHPVFNP 773
            ++P  G++  +  +DRE+ P +Y   V A DG   G LS    V + + DVND+ P F  
Sbjct: 1904 LEPSSGELRTAAALDREQCP-SYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPT 1962

Query: 774  STYVTSI----SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY 829
            S     +       + P   +  + A D+D+G   ++ Y L  G      T+DS TG I 
Sbjct: 1963 SPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGTPPPGTTVDSYTGEIR 2021

Query: 830  LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
            +      L      L + A D G         + + +         F R      + E+ 
Sbjct: 2022 VARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENA 2081

Query: 890  PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVV 947
            P  +PI + +A     ++ PI Y I SG+  G FSI P  G  T+R+ + LD E  P + 
Sbjct: 2082 PPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLR 2141

Query: 948  LTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 1007
            L +QA+ G A A   T + +T+ D NDN P FLR      + ++ P    L    A+D D
Sbjct: 2142 LVLQAESGGAFA--FTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199

Query: 1008 SGRNGLIRYSIASPQP--GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAA 1065
             G  G I YS+A+ QP  G+F +D   G +     L      E  L L A D+G      
Sbjct: 2200 QGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVG 2259

Query: 1066 LLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL 1124
               LTV VI+  ++ P+       +++ VSE     +++ Q   + +    +   L Y L
Sbjct: 2260 SATLTVMVIDTNDNRPTIP---QPWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVL 2313

Query: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVWD 1183
             PS     F +  Y G + L    D+E    Y  ++ A   P +G     + TV+V   D
Sbjct: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG---RANLTVLVE--D 2368

Query: 1184 ENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 1243
             NDN+P F   +  + + E   P   I  ++A D DSG NG + Y L S    F ++PN 
Sbjct: 2369 VNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNN 2428

Query: 1244 GEL---INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
            G L   +  VAL  +  G  ++ +   D G+P R A   V+V + D ND+ P F      
Sbjct: 2429 GTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL---- 2484

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYSVSS 1339
                V V E  P    + T+ A D D   ++A V YS+ S
Sbjct: 2485 SHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIIS 2524



 Score =  369 bits (947), Expect = e-101
 Identities = 376/1275 (29%), Positives = 535/1275 (41%), Gaps = 139/1275 (10%)

Query: 116  FHVHPDTGIIRTARRLDRERR-DHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPL 169
            F +H  TG +   R LDRE+R +H   V A+  G     A   + + V DVND +P F  
Sbjct: 1592 FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQ 1651

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
                + + E +PPGT+     A DPD G      Y  V       DP             
Sbjct: 1652 QEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDP------------- 1698

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
                          +   L  LR LDREE     L + A D G P +   ++V + V DE
Sbjct: 1699 --------------DTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744

Query: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
            ND+ P F        V E   P   +  +RA+D D+G NG ++Y +      GA      
Sbjct: 1745 NDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGA------ 1797

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
                  F ++  SG     RPLDRE +   QL +EARDGG     AT+ +++ VLD ND+
Sbjct: 1798 ------FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDH 1851

Query: 410  RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
             PA  V   +      V E    G  + ++   D D        A G +   LG G+   
Sbjct: 1852 APAFPVPAYS----VEVPEDVPAGTLLLQLQAHDPDAG------ANGHVTYYLGAGTA-- 1899

Query: 470  SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD-AGSPPLSTEETLLLR 528
                  G F L P        L     LDRE    Y   + A D A + PLST  ++ + 
Sbjct: 1900 ------GAFLLEPSSGE----LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTIT 1949

Query: 529  VADLNDQPPLFSQQHYKASVSEA----AAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
            V D+ND  P F     +  +       + P   +  + A D D AG++            
Sbjct: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRD-AGAN------------ 1996

Query: 585  APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
                  S+  ++  T    P   +DS +G I   R+          L +VA DLG P  S
Sbjct: 1997 -----ASILYRLAGTPP--PGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARS 2049

Query: 645  ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
            AT ++ + +    +  P F R    ATI E+AP G   +   A  A  G  G I YS+  
Sbjct: 2050 ATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYSILS 2108

Query: 705  GFLSYEAPQAFRIDPHDGQICV--SQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE 762
            G         F I P  G I V  ++ +D E  P     LV   + GG  A   + + L+
Sbjct: 2109 G----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLR--LVLQAESGGAFAFTVLTLTLQ 2162

Query: 763  DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS-SLFTI 821
            D NDN P F    YV  + +       ++ V A D D G  G ++Y L     +  LF +
Sbjct: 2163 DANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHV 2222

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            D TTG I  T  L         L++ A D G    V +A +T+ +  T        +P +
Sbjct: 2223 DPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-W 2281

Query: 882  TFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE 941
               V ED    S I  V   + ++S   ++Y +S       FS+    G +    PLD E
Sbjct: 2282 ELRVSEDALLGSEIAQVTGND-VDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE 2340

Query: 942  TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
                  L + A  G  P      + + V DVNDN PAF ++  ++ + + TPPG+A+   
Sbjct: 2341 QCDRYQLQLLAHDG--PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398

Query: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTLTLRAEDQ 1058
             A DRDSG NG I Y +ASP  G F++D   G LF      +LG      + + L A D 
Sbjct: 2399 SATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457

Query: 1059 GVHPQAALLVLTVVIE-KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 1117
            G   +AA   + V ++ + +H+PS+T  H  Y+V V+E L P + +L  +A      R+ 
Sbjct: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSH--YRVAVTEDLPPGSTLLTLEATDADGSRSH 2515

Query: 1118 SPLRYS-----------LEPSVDSAMFGIRP---YTGWIYLRRQFDYESTQTYNFRVFAW 1163
            + + YS           LEP +  A     P     G + L    D+ES   YN  V A 
Sbjct: 2516 AAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA- 2574

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
                   Q+    V V V D NDN P F      + V E       +  + A D D G +
Sbjct: 2575 ADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPH 2634

Query: 1224 GQLLYFLLSDGK---FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 1280
            G L+ F +S G     F+++ ++G L    ALD E +  H++ V   D       A   V
Sbjct: 2635 G-LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGA-HFALAPV 2692

Query: 1281 YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
             + V D+ND+ P FP  L    L   V E QP   LVTT+ A D D G    + YS+  A
Sbjct: 2693 TIEVQDVNDHGPAFPLNL----LSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEA 2748

Query: 1341 RPMPLKGKTAFGKQS 1355
             P P +G+ AF   S
Sbjct: 2749 GPGP-EGREAFALNS 2762



 Score =  351 bits (900), Expect = 3e-96
 Identities = 386/1338 (28%), Positives = 548/1338 (40%), Gaps = 197/1338 (14%)

Query: 73   VDEGLPPDTLVGDIRAGLPA--------AQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
            V E  PP  LV  I    P            + G G F     D    L           
Sbjct: 375  VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL----------- 423

Query: 125  IRTARRLDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLD-VS 177
            +  ARRLDRE RD Y+  V AT  G     A     + V DVND++P F     + + + 
Sbjct: 424  VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483

Query: 178  ELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLP 237
            E++ PG+      A DPD G                             T G +   L P
Sbjct: 484  EVALPGSFVVRVTARDPDQG-----------------------------TNGQVTYSLAP 514

Query: 238  GSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
            G+ +    +D     +     LD E     +L + A DGG P      +V + + D NDN
Sbjct: 515  GAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDN 574

Query: 293  PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
             P F++  Y A++ E  QPG    +V ATD D GP G + YS+ A    G GS G     
Sbjct: 575  EPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA----GLGSSG----- 625

Query: 353  AAYFAVEELSGVVRVWRPLDRE-AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
            +  F ++  SG V   R LDR+   +     V A DGG    +  V+V ++  D NDN P
Sbjct: 626  SPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--DENDNPP 683

Query: 412  AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSL 471
                 F      A +S  + PG  V R+   D D                          
Sbjct: 684  Q----FYPREYAASISAQSPPGTAVLRLRAHDPD-------------------------- 713

Query: 472  EGGEG--DFALLPGGPPGVF-------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
            +G  G   + +L G  P +F        L V  PL R +  + +L + A D G       
Sbjct: 714  QGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS 773

Query: 523  ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
              + + +      PP+F Q  Y  SV E  APGT V  V A +           R   V 
Sbjct: 774  ARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPG--------RLAPVT 825

Query: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
            LS            +   +    F++D+ SG + T+R LDRE+   V    V    G PP
Sbjct: 826  LS------------LSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPP 873

Query: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSL 702
              A   V + +DDVNDN P F        +  +   G     + A D DSG+   + ++L
Sbjct: 874  AFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL 933

Query: 703  YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVD 760
              G        AF +DP  G + + + +     PA ++L +EA+DGG    ++   +RV 
Sbjct: 934  LAG-----GGGAFTVDPTTGHVRLMRPLGPSGGPA-HELELEARDGGSPPRTSHFRLRVV 987

Query: 761  LEDVNDNH--PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
            ++DV      P FN  TY   +   T  GT+++ V A   D G    + Y L     SS 
Sbjct: 988  VQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSP 1044

Query: 819  FTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDG-----GGLTAVINADVTIHIFQTTLAP 873
            F ++  +G +++   L         L V A  G     G  T      V+I + Q   +P
Sbjct: 1045 FGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI-LNQNEHSP 1103

Query: 874  AEFERPKYTFL-VYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGDLGGK-FSIHPR 928
               E P  TFL V E+ P  + +G V A +    S P   + Y +       K F IHP+
Sbjct: 1104 RLSEDP--TFLAVAENQPPGTSVGRVFATD--RDSGPNGRLTYSLQQLSEDSKAFRIHPQ 1159

Query: 929  LGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDE-- 985
             G + T + LD E Q    L VQ Q G +P  S+T  V++ V+D+NDN P FL+ S    
Sbjct: 1160 TGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1219

Query: 986  ----IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL 1041
                I++    PPGT +   +A+D D G NG I Y++  P   +F++    G L     L
Sbjct: 1220 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPL 1279

Query: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-----------EKREHSPSWTFEHLVYQ 1090
               E+    LTL A DQG  P++A L L V +           +  E  P+     +V  
Sbjct: 1280 IRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVP-VVLT 1338

Query: 1091 VEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVD-SAMFGIRPYTGWIYLRRQFD 1149
            V  +E L P   +L + A P         L Y+L    D    F +   +G +YL R  D
Sbjct: 1339 VTAAEGLRP-GSLLGSVAAP--EPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395

Query: 1150 YESTQTYN-FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG 1208
            +E+   +    V A  P  G        V V+V DEN+++P F  D L L + E+P P  
Sbjct: 1396 FEAGPPWRALTVRAEGP--GGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGA 1453

Query: 1209 VIGKITAIDMDS-GKNGQLLYFLLSDG---KFFKMNPNTGELINWVALDREHRGHHEMTV 1264
             +    A D D  G N  + Y LL         +++  TG L     LDRE      + V
Sbjct: 1454 ALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLV 1513

Query: 1265 LVTDR---GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF 1321
              TDR    S  R A ++  V VTD NDN P F          V++ E QP       V 
Sbjct: 1514 EATDRPANASRRRAARVSARVFVTDENDNAPVF-----ASPSRVRLPEDQPPGPAALHVV 1568

Query: 1322 AKDPDEGNNAEVTYSVSS 1339
            A+DPD G  A V+Y ++S
Sbjct: 1569 ARDPDLGEAARVSYRLAS 1586



 Score =  347 bits (891), Expect = 3e-95
 Identities = 393/1329 (29%), Positives = 575/1329 (43%), Gaps = 134/1329 (10%)

Query: 73   VDEGLPPDTLVGDIRAG--LPAAQQQEGSGFFLSEDSDDSPLL----DDFHVHPDTGI-- 124
            +D  L    L  ++RAG  +P A         L + +D+SP      D   + P+T    
Sbjct: 852  LDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGT 911

Query: 125  -IRTARRLDRERRDHYSFVAATLL---GAVVQVEIRVNDVNDHSPRFP----LDSLQLDV 176
             I T R LD +   + S V  TLL   G    V+     V    P  P       L+L+ 
Sbjct: 912  PIYTLRALDPDSGVN-SRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEA 970

Query: 177  SEL-SPPGTA-FRLPVAHDPDAGL------FSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
             +  SPP T+ FRL V    D G       F++  Y +  PS           Q +    
Sbjct: 971  RDGGSPPRTSHFRLRVVVQ-DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDG 1029

Query: 229  GPLPSPLLP-GSSSP--LEPLD--LVLLRRLDREEAAAHRLQIEAWDGGRP---RRTGLL 280
            GP+   L   G+SSP  LEP    L +   LDRE    + L++ A  G +    ++TG  
Sbjct: 1030 GPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTA 1089

Query: 281  SVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340
            +V + +L++N++ P   +D    AV E+  PG  V RV ATDRD GPNG + YS++    
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149

Query: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVS 400
                       D+  F +   +G V   + LDRE Q+ +QL+V+ +DGG+ P   T  V 
Sbjct: 1150 -----------DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVH 1198

Query: 401  IAVLDVNDNRPAIHVLFLTEGGVA------RVSEGARPGDYVARVSVSDADGDWEKEDEA 454
            +AVLD+NDN P     FL   G A      +V +   PG  V  +   D D     E E 
Sbjct: 1199 VAVLDLNDNSPT----FLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPD-----EGEN 1249

Query: 455  TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
               L    G GS   SL    G+             L    PL R  R  Y L L A D 
Sbjct: 1250 GTILYTLTGPGSELFSLHPHSGE-------------LLTAAPLIRAERPHYVLTLSAHDQ 1296

Query: 515  GSPPLSTEETLLLRV---ADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGS 571
            GSPP S    LL++V   A L + PP  +++       + AAP  VV+ V+A++    GS
Sbjct: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAER-------DPAAPVPVVLTVTAAEGLRPGS 1349

Query: 572  DHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVEL 631
                     V    P  +G+L   +V  A+   +FA+D+ SG +   R LD E       
Sbjct: 1350 -----LLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRA 1404

Query: 632  KVVAQDLGEPPLSATCL-VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDA 690
              V  + G     A  L V + V D N++ P F R      + E+   G       ASDA
Sbjct: 1405 LTVRAE-GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDA 1463

Query: 691  DS-GLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD- 747
            D  G    + Y L    L  E P  A R+D   G +   + +DRE  PA   LLVEA D 
Sbjct: 1464 DGPGPNSDVRYRL----LRQEPPVPALRLDARTGALSAPRGLDRETTPALL-LLVEATDR 1518

Query: 748  ----GGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIY 803
                    +A+   RV + D NDN PVF   + V  + ++  PG   ++V+A D D G  
Sbjct: 1519 PANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVARDPDLGEA 1577

Query: 804  GTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVT 863
              V+Y L  G     F + S+TG + +  PL   +     L V A D G         +T
Sbjct: 1578 ARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLT 1636

Query: 864  IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGK 922
            + +         F++ +Y+ L+ E+ P  + + T++A +P + ++  + Y    G     
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSES 1693

Query: 923  FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLR 981
            FS+ P  G + T + LD E Q  + LTV AQ  GS P  +   V + V D ND+ P F  
Sbjct: 1694 FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1753

Query: 982  TSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGS 1040
                + + +   P T L + RA D D G NG ++Y I    P G F +D A G       
Sbjct: 1754 AHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRP 1812

Query: 1041 LGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSP 1099
            L    +    L + A D G    +A L+LTV V++  +H+P+  F    Y VEV E +  
Sbjct: 1813 LDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPA--FPVPAYSVEVPEDVPA 1870

Query: 1100 MTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
             T +LQ QAH   P   A+  + Y L      A F + P +G +      D E   +Y F
Sbjct: 1871 GTLLLQLQAH--DPDAGANGHVTYYLGAGTAGA-FLLEPSSGELRTAAALDREQCPSYTF 1927

Query: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEES----PVPQGVIGKIT 1214
             V A         + + +V + V D ND++PTF    L L++         P   +  + 
Sbjct: 1928 SVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR 1987

Query: 1215 AIDMDSGKNGQLLYFLL-SDGKFFKMNPNTGEL---INWVALDREHRGHHEMTVLVTDRG 1270
            A D D+G N  +LY L  +      ++  TGE+    + VAL    R    + ++ TD G
Sbjct: 1988 AEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDR---VLFIVATDLG 2044

Query: 1271 SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
             P R+AT  + V +    +  P FP+      +      G P+ +    V A     G N
Sbjct: 2045 RPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI-VSPRAVHA----GGTN 2099

Query: 1331 AEVTYSVSS 1339
              +TYS+ S
Sbjct: 2100 GPITYSILS 2108



 Score =  346 bits (888), Expect = 8e-95
 Identities = 384/1343 (28%), Positives = 567/1343 (42%), Gaps = 182/1343 (13%)

Query: 74   DEGLPPDTL-------VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL------------- 113
            D G PP +        V D+    P  QQQE S      +   + LL             
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682

Query: 114  ---------DDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVN 158
                     + F + PDTG++ T R LDRE ++  +  V A   G+  Q     V + V 
Sbjct: 1683 QVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742

Query: 159  DVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
            D NDH+P F    L L+V E   P T   L  A DPD G      Y +     L  DP+G
Sbjct: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLR-ASDPDVGANGQLQYRI-----LDGDPSG 1796

Query: 219  PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG 278
             F              L  G    + PLD        RE   A +L+IEA DGG+P  + 
Sbjct: 1797 AFVL-----------DLASGEFGTMRPLD--------REVEPAFQLRIEARDGGQPALSA 1837

Query: 279  LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
             L + + VLD ND+ P F    Y   V ED   G  + +++A D D G NG V Y +   
Sbjct: 1838 TLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--- 1894

Query: 339  QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATV 397
               GAG+ G        F +E  SG +R    LDRE    +   V A DG A  P   TV
Sbjct: 1895 ---GAGTAGA-------FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV 1944

Query: 398  RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
             V+I V DVND+ P     F T     R+    RPG   +  +++ A      ED   G 
Sbjct: 1945 SVTITVRDVNDHAPT----FPTSPLRLRLP---RPGPSFSTPTLALAT--LRAEDRDAG- 1994

Query: 458  LGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEG-------PLDRESRDLYELLLV 510
                  + SI   L G           PPG       G       P+    RD   L +V
Sbjct: 1995 -----ANASILYRLAGTP---------PPGTTVDSYTGEIRVARSPVALGPRDRV-LFIV 2039

Query: 511  ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
            ATD G P  S    +++ +    ++ P F +   +A++ E A PGT ++   +  A  AG
Sbjct: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV---SPRAVHAG 2096

Query: 571  SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
              +  + Y+++  +                E G +F+I   +GAI T+R+   LD EV  
Sbjct: 2097 GTNGPITYSILSGN----------------EKG-TFSIQPSTGAI-TVRSAEGLDFEVSP 2138

Query: 628  AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
             + L + A+  G     A  ++++T+ D NDN P F R  Y A + E  P+    LQV A
Sbjct: 2139 RLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEA 2195

Query: 688  SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
             D D G  G I YSL     S  A   F +DP  G I  +  +DRE    T  +L+    
Sbjct: 2196 DDLDQGSGGQISYSLA---ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDR 2252

Query: 748  GG-GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTV 806
            G   L   A + V + D NDN P   P  +   +S++   G+EI  V   D DSG    +
Sbjct: 2253 GSPALVGSATLTVMVIDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSG--PVL 2309

Query: 807  AYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI 866
             Y L P      F++    G + LT PL   +     L + A DG        A++T+ +
Sbjct: 2310 WYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG---RANLTVLV 2366

Query: 867  FQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSI 925
                     F +  Y  ++ E  P  S I +V A +    ++  I Y ++S   G  FS+
Sbjct: 2367 EDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSV 2424

Query: 926  HPRLGTIRT---RKPLDHETQPVVVLTVQAQLGSAPA-CSSTEVNITVMDVNDNHPAFLR 981
             P  GT+ T      L H+    V + ++A+   AP   +   V++ + D ND+ P+F  
Sbjct: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL 2484

Query: 982  TSDEIRISQTTPPGTALYLARAEDRDSGRN-GLIRYSIASPQPG-VFAID---------- 1029
            +   + +++  PPG+ L    A D D  R+   + YSI S   G VF ++          
Sbjct: 2485 SHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESA 2544

Query: 1030 ----RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 1085
                RALG L L   L      +  LT+ A D+G  PQ++++ +TV +     +P   F 
Sbjct: 2545 GPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPP-VFT 2603

Query: 1086 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 1145
               Y+V V E      ++L  +A    P      +R+++     S +F +   +G + L 
Sbjct: 2604 RASYRVTVPEDTPVGAELLHVEASDADPGPHGL-VRFTVSSGDPSGLFELDESSGTLRLA 2662

Query: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 1205
               D E+   +   V A  P          T+ V+  D ND+ P F  ++L   V E+  
Sbjct: 2663 HALDCETQARHQLVVQAADPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAENQP 2720

Query: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG------KFFKMNPNTGELINWVALDREHRGH 1259
            P  ++  + AID D+G  G+L Y LL  G      + F +N +TGEL   V  D EH   
Sbjct: 2721 PGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES 2780

Query: 1260 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 1319
              + V   D G+   + T++V V+  D  D  P F         H +V EG      +  
Sbjct: 2781 FRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVF----LAPAFHFQVPEGARRGHSLGH 2834

Query: 1320 VFAKDPDEGNNAEVTYSVSSARP 1342
            V A D D G +  V YS++++ P
Sbjct: 2835 VQATDEDGGADGLVLYSLATSSP 2857



 Score =  337 bits (864), Expect = 5e-92
 Identities = 357/1279 (27%), Positives = 531/1279 (41%), Gaps = 171/1279 (13%)

Query: 68   NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127
            +L+L V EG  P TL       L A+    G+   L     D      F +   +G   T
Sbjct: 1755 HLSLEVPEGQDPQTLTM-----LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGT 1809

Query: 128  ARRLDRERRDHYSFVAAT------LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
             R LDRE    +             L A + + + V D NDH+P FP+ +  ++V E  P
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVP 1869

Query: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
             GT      AHDPDAG      Y L   +      AG F              LL  SS 
Sbjct: 1870 AGTLLLQLQAHDPDAGANGHVTYYLGAGT------AGAF--------------LLEPSSG 1909

Query: 242  PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR--PRRTGLLSVELRVLDENDNPPVFEQD 299
             L          LDRE+  ++   + A DG    P  T  +SV + V D ND+ P F   
Sbjct: 1910 ELRTA-----AALDREQCPSYTFSVSAVDGAAAGPLST-TVSVTITVRDVNDHAPTFPTS 1963

Query: 300  EYRAAVRED----AQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY 355
              R  +       + P   +  +RA DRD G N  + Y +     PG             
Sbjct: 1964 PLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGT------------ 2011

Query: 356  FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
              V+  +G +RV R           L + A D G     AT  + + +    +  P    
Sbjct: 2012 -TVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPR--- 2067

Query: 416  LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG- 474
             F      A + E A PG  +       A G                 +G I+ S+  G 
Sbjct: 2068 -FPRASSEATIRENAPPGTPIVSPRAVHAGGT----------------NGPITYSILSGN 2110

Query: 475  -EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
             +G F++ P    G   +     LD E      L+L A   G+   +    L L + D N
Sbjct: 2111 EKGTFSIQPS--TGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTV---LTLTLQDAN 2165

Query: 534  DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
            D  P F + HY A + E+      ++ V A D D+                     G + 
Sbjct: 2166 DNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG------------------GQIS 2207

Query: 594  SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
              +  +      F +D  +G I+T   LDRE+     L ++A D G P L  +  +++ V
Sbjct: 2208 YSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMV 2267

Query: 654  DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
             D NDN P    Q +   ++E A +G    QVT +D DSG   +         LS   PQ
Sbjct: 2268 IDTNDNRPTI-PQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWY-------VLSPSGPQ 2319

Query: 714  -AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFN 772
              F +  + G++ ++  +D E+    Y L + A DG     +A + V +EDVNDN P F+
Sbjct: 2320 DPFSVGRYGGRVSLTGPLDFEQCDR-YQLQLLAHDGPH-EGRANLTVLVEDVNDNAPAFS 2377

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL-- 830
             S Y   + + T PG+ I++V ATD+DSG  G ++Y L   + +  F++D   G ++   
Sbjct: 2378 QSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL--ASPADGFSVDPNNGTLFTIV 2435

Query: 831  -TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
             T+ L H  S  + +++ A+D G       A V + +         F    Y   V ED+
Sbjct: 2436 GTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDL 2495

Query: 890  PEDSPIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRL--------------GTIR 933
            P  S + T++A +     S   + Y I SG+ G  F + PRL              G + 
Sbjct: 2496 PPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLV 2555

Query: 934  TRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
              +PLD E+     LTV A   G  P  S   V +TV+DVNDN P F R S  + + + T
Sbjct: 2556 LLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTL 1051
            P G  L    A D D G +GL+R++++S  P G+F +D + G L L  +L    Q    L
Sbjct: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675

Query: 1052 TLRAEDQ-GVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
             ++A D  G H   AL  +T+ ++   +H P++    L     V+E+  P T  L T  H
Sbjct: 2676 VVQAADPAGAH--FALAPVTIEVQDVNDHGPAFPLNLL--STSVAENQPPGT--LVTTLH 2729

Query: 1110 PL-GPQRAASPLRYSL---EPSVDSA-MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
             + G   A   LRYSL    P  +    F +   TG +  R  FDYE T++  FR+    
Sbjct: 2730 AIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTES--FRLLVGA 2787

Query: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
             + G L + S TV V V  E++  P FL      +V E       +G + A D D G +G
Sbjct: 2788 ADAGNL-SASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADG 2846

Query: 1225 QLLYFLLSDGKFFKMNPNTGELINWVALDREHRGH----------------HEMTVLVTD 1268
             +LY L +   +F +N  TG L  ++ +D    G                  E+ + V  
Sbjct: 2847 LVLYSLATSSPYFGINQTTGAL--YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA 2904

Query: 1269 RGSPP--RNATMAVYVSVT 1285
            RG  P  R+AT+ V V +T
Sbjct: 2905 RGPLPGSRSATVPVTVDIT 2923



 Score =  165 bits (418), Expect = 2e-40
 Identities = 178/660 (26%), Positives = 272/660 (41%), Gaps = 52/660 (7%)

Query: 717  IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTY 776
            ID H G +  ++ +DRE+    Y       DG    A   V V + D+ND+ P F  +  
Sbjct: 94   IDEHSGVVRTARVLDREQRDR-YRFTAVTPDG----ATVEVTVRVADINDHAPAFPQARA 148

Query: 777  VTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGI-------IY 829
               + + T  GT      A D D+G  GT  Y L        F +++  G        + 
Sbjct: 149  ALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELV 208

Query: 830  LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
            +T  L     +   L + A DGG       A + + +         F + +Y  +V E +
Sbjct: 209  VTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESL 268

Query: 890  PEDSPIGTVKAREP-LNSSEPIFYRI----SSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
               SP+  V A +     +  + Y I    S GD  G FSI    G ++  +PLD E + 
Sbjct: 269  APGSPVLQVFASDADAGVNGAVTYEINRRQSEGD--GPFSIDAHTGLLQLERPLDFEQRR 326

Query: 945  VVVLTVQAQLGSA-PACSSTEVNITVMDVNDNHPA----FLRTSDEIRISQTTPPGTALY 999
            V  L VQA+ G A P   S  V + V D NDN P+    FL      ++S+  PPG  + 
Sbjct: 327  VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386

Query: 1000 LARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTLTLRAE 1056
                 D D G    +  S+   + G FA+     V++L      L   E+    L + A 
Sbjct: 387  RISVSDPDDGDFAHVNVSLEGGE-GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445

Query: 1057 DQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE-VSESLSPMTQMLQTQAHPLGPQ 1114
            D G  P  A     + V +  +++P+  F+  +Y+ E + E   P + +++  A     Q
Sbjct: 446  DSGSPPLRAEAAFVLHVTDVNDNAPA--FDRQLYRPEPLPEVALPGSFVVRVTARD-PDQ 502

Query: 1115 RAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV- 1173
                 + YSL P   +  F I P +G I      DYE        V A    DG L  + 
Sbjct: 503  GTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVA---TDGGLPPLA 559

Query: 1174 -STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL-- 1230
             S TV V + D NDN P F        + E   P     ++TA D DSG  G L Y L  
Sbjct: 560  SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGA 619

Query: 1231 ---LSDGKFFKMNPNTGELINWVALDREHR-GHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
                S    F+++ ++G++     LDR+      + TV   D G       + V++S  D
Sbjct: 620  GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLS--D 677

Query: 1287 INDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
             NDN P F+P     +E    +    P    V  + A DPD+G++  ++Y + +    PL
Sbjct: 678  ENDNPPQFYP-----REYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPL 732



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 4/154 (2%)

Query: 61   GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
            G +  L  L+ SV E  PP TLV  + A    A       + L E        + F ++ 
Sbjct: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762

Query: 121  DTGIIRTARRLDRERRDHYSFVA----ATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
             TG +R     D E  + +  +     A  L A V V + V   +++ P F   +    V
Sbjct: 2763 STGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQV 2822

Query: 177  SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             E +  G +     A D D G      Y+L   S
Sbjct: 2823 PEGARRGHSLGHVQATDEDGGADGLVLYSLATSS 2856


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  503 bits (1295), Expect = e-142
 Identities = 418/1312 (31%), Positives = 620/1312 (47%), Gaps = 132/1312 (10%)

Query: 57   WAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDF 116
            W       Q+F +     E  PP TLVG I       Q + G  + LSE    S  L  F
Sbjct: 39   WVHGAEPRQVFQVL----EEQPPGTLVGTI-------QTRPGFTYRLSE----SHAL--F 81

Query: 117  HVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVV---QVEIRVNDVNDHSPRFPLDSLQ 173
             ++  TG + T   +DRE           L  A     +V + V D+ND++P FP  S+ 
Sbjct: 82   AINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIV 141

Query: 174  LDVSELSPPGTAFRLPVAHDPDAGLFST--QGYTLVQPSDLPKDPAGPFFQLRYRTPGPL 231
            +   E S  G    L  A D D G      + Y +++ ++     AG F          L
Sbjct: 142  VTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNE-----AGRF---------RL 187

Query: 232  PSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEND 291
               L P        L LV    LDRE    ++L +E  D G P+R G L V + V D ND
Sbjct: 188  DITLNPSGEGAF--LHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDIND 245

Query: 292  NPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALG 351
            NPPVF    Y+A V EDA  G+ V +V A D D G N  +RY ++    P          
Sbjct: 246  NPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP---------- 295

Query: 352  DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
                F ++  +G++ V  PLD EA+  + L V+A D G           I +LDVNDN P
Sbjct: 296  ----FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDP 351

Query: 412  AIHV-LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
             +    F      A V E A+ G  VA ++V+DAD                  +G+IS+ 
Sbjct: 352  VVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSP--------------AANGNISVQ 397

Query: 471  LEGG--EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLL-VATDAGSPP------LST 521
            + GG  +  F +     P +  + V   LDRE    Y L + V+ + G+PP       S+
Sbjct: 398  ILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSS 457

Query: 522  EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
              +L++ V D+ND PP+FSQQ Y+ ++SE A PG+ V  +SA+D D     +A LRY++V
Sbjct: 458  VASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGD--SGLNANLRYSIV 515

Query: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT--LDREVQEAVELKVVAQDLG 639
              +    LG               F I   SG ++T  +  LDRE+   + L + A+D G
Sbjct: 516  SGN---GLG--------------WFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQG 558

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWR-QVYNATIAEHAPVGHCFLQVTASDADSGLYGFI 698
              P  +   + +T+ DVND +P+F + + Y+ ++ E+AP G   L + A+D D G  G +
Sbjct: 559  VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV 618

Query: 699  EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAF 756
             +SL +   +    ++FR+DP  G++     +DRE + A Y LLV A D G    S+ A 
Sbjct: 619  RFSLQE---AETDRRSFRLDPVSGRLSTISSLDRE-EQAFYSLLVLATDLGSPPQSSMAR 674

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            + V L D+NDN PVF P  Y   I +    G+ I  V ATD D G  GTV Y +  G+  
Sbjct: 675  INVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGD-R 733

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
            S F +++ +G+I   + L   E T   L + A DGG L +   A VTI +  T   P  F
Sbjct: 734  SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVF 793

Query: 877  ERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 936
             +  Y+F+V+E+V     +G+V A   ++ +  I Y I++GD  G F+I+   G + T  
Sbjct: 794  SQVAYSFVVFENVALGYHVGSVSA-STMDLNSNISYLITTGDQKGMFAINQVTGQLTTAN 852

Query: 937  PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
             +D E Q    L V A  G+      T VNITV D+NDN P FL+  + + + +    G 
Sbjct: 853  VIDREEQSFYQLKVVASGGT--VTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGH 910

Query: 997  ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE 1056
            +++ A+A D D G NG++ YS+      +FAI+   G + L G L         + + A 
Sbjct: 911  SIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDV-HAGSYQIEILAS 969

Query: 1057 DQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQR 1115
            D GV   ++ ++LTV + +  ++SP   F+ L Y+V +SES    ++  + QA       
Sbjct: 970  DMGVPQLSSSVILTVYVHDVNDNSP--VFDQLSYEVTLSESEPVNSRFFKVQASD-KDSG 1026

Query: 1116 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 1175
            A   + Y++        FGI P  G +Y++ + D E    Y   V A    D  ++ +S 
Sbjct: 1027 ANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDRYVLMVVA---SDRAVEPLSA 1082

Query: 1176 TVIVRV--WDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
            TV V V   D NDN P F         EE       +GK++A+D D G NG++ Y     
Sbjct: 1083 TVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMV 1142

Query: 1234 GKFFKMNPNTGELINWVALDRE----HRGH--HEMTVLVTDRGSP-PRNATMAVYVSVTD 1286
               F+++  +GE+ N    DRE     RG      TV+ TD+G P P      V+V + D
Sbjct: 1143 QPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKD 1202

Query: 1287 INDNRPFFPQCLPGKELHVKVLEGQPVNML-VTTVFAKDPDEGNNAEVTYSV 1337
            INDN P F      K+ +   +     N+  V  V A D DEGNN  + YS+
Sbjct: 1203 INDNAPKFL-----KDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSI 1249



 Score =  424 bits (1089), Expect = e-118
 Identities = 378/1294 (29%), Positives = 563/1294 (43%), Gaps = 147/1294 (11%)

Query: 75   EGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE 134
            EG P  T V  I A  P   +     + +S   ++  +   F +   TGII+TA  LDRE
Sbjct: 1640 EGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE 1699

Query: 135  RR------DHYSFVAATLLGAV--VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
            +       D Y+   +T        +VEI + D+ND+ P FP D L L V E    G+  
Sbjct: 1700 QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKI 1759

Query: 187  RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
                A D D G  +   YT++  +D                            S  ++P 
Sbjct: 1760 MQLTAMDADEGANALVTYTIISGAD---------------------------DSFRIDPE 1792

Query: 247  --DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              DL+  RRLDRE  + + L + A DG    ++  + + + V D ND+ P F +  Y   
Sbjct: 1793 SGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSFD 1849

Query: 305  VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
            + ED  PG+ V  + ATD D G NG + Y V      G             F +  ++GV
Sbjct: 1850 IPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGI------------FFLNPITGV 1897

Query: 365  VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
              + R LD E Q ++ L V A DGG +    T+RV   +LDVNDN P    +F       
Sbjct: 1898 FNLTRLLDYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPP----IFSLNSYST 1951

Query: 425  RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
             + E    G  V   +V+DAD      D    +L   +  G          G F +   G
Sbjct: 1952 SLMENLPVGSTVLVFNVTDAD------DGINSQLTYSIASGD-------SLGQFTVDKNG 1998

Query: 485  PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLS---TEETLLLRVADLNDQPPLFSQ 541
                  L V   LDRES+  Y L++   D    P S   +   + + + D+ND PP F  
Sbjct: 1999 -----VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLS 2053

Query: 542  QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
                  + E     TVV    A+D D     ++++ YT++                    
Sbjct: 2054 PKL-TYIPENTPIDTVVFKAQATDPDSG--PNSYIEYTLLN------------------P 2092

Query: 602  CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
             G  F+I +  G +     LDRE      L VVA D G+P LS++  V + V D+NDN P
Sbjct: 2093 LGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNP 2152

Query: 662  IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHD 721
            IF + +Y   I E+   G   +QV A+D D G  G + Y + +G       Q FRID   
Sbjct: 2153 IFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG----NTNQEFRIDSVT 2208

Query: 722  GQICVSQDIDRERDPATYDLLVEAKDGGGL--SAQAFVRVDLEDVNDNHPVFNPSTYVTS 779
            G I V++ +DRE+ P TY L V+A D G    +  + V + L D+ND  PVF  S Y  +
Sbjct: 2209 GAITVAKPLDREKTP-TYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVN 2267

Query: 780  ISDE--TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL 837
            + +   T P T I+ V+A D D G    ++Y L  GN  + FT+ S +G + +T  L   
Sbjct: 2268 VPENLGTLPRT-ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRE 2325

Query: 838  ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT 897
                  LM++A D G         + + +         F    Y    +  +PED+P GT
Sbjct: 2326 TKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAY----FTTIPEDAPTGT 2381

Query: 898  ----VKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ-A 952
                V A +  ++S+    RI  G+   +F+I+P  G I T   LD ET+    L V  +
Sbjct: 2382 DVLLVNASDA-DASKNAVIRIIGGN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCS 2438

Query: 953  QLGSA-PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRN 1011
              GS  P  SST V +TV DVNDN P F        I   T PG+ ++     D D G N
Sbjct: 2439 DAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPN 2498

Query: 1012 GLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 1071
              + YS++      F ID   G +   G L      E+T ++  +D G  P+     +TV
Sbjct: 2499 SELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGAS--EVTFSVHVKDGGSFPKTDSTTVTV 2556

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA 1131
                +   P    +   +    ++ +S +   +       G      P+ Y +       
Sbjct: 2557 RFVNKADFPKVRAKEQTFMFPENQPVSSLVTTIT------GSSLRGEPMSYYIASGNLGN 2610

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP-EDGFLQNVST--TVIVRVWDENDNS 1188
             F I   TG + + +  D+E  Q Y      WI   DG     S+   + + V D NDN+
Sbjct: 2611 TFQIDQLTGQVSISQPLDFEKIQKY----VVWIEARDGGFPPFSSYEKLDITVLDVNDNA 2666

Query: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGEL 1246
            P F  D    ++ E+  P+ ++  ++A+D DSG NGQL Y +++      F +N  TGE+
Sbjct: 2667 PIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEI 2725

Query: 1247 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 1306
             +   LDRE   H+ +T+  +D+GSP ++ ++ V +++ D NDN P F Q          
Sbjct: 2726 RSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAH----- 2780

Query: 1307 VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
            V E  P+   VT V   D D G NA   YS+  A
Sbjct: 2781 VPENSPLGYTVTRVTTSDEDIGINAISRYSIMDA 2814



 Score =  423 bits (1088), Expect = e-118
 Identities = 386/1306 (29%), Positives = 592/1306 (45%), Gaps = 138/1306 (10%)

Query: 76   GLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRER 135
            G+P D +VG     + AA   EG+   +     D      F + P+TG+I     LD E 
Sbjct: 258  GVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGT--PFQMDPETGLITVREPLDFEA 315

Query: 136  RDHYSFVAATL------LGAVVQVEIRVNDVNDHSP-----RFPLDSLQLDVSELSPPGT 184
            R  YS     +      L    +  I++ DVND+ P      FP  S    V E +  GT
Sbjct: 316  RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGT 375

Query: 185  AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
               L    D D+   +  G   VQ         G   Q  +              SS + 
Sbjct: 376  VVALLTVTDADSP--AANGNISVQI-------LGGNEQRHFEV-----------QSSKVP 415

Query: 245  PLDLV-LLRRLDREEAAAHRLQIEAWDG-GRP------RRTGLLSVELRVLDENDNPPVF 296
             L L+ +   LDRE   ++ L +   D  G P       R+ + S+ + V D ND+PPVF
Sbjct: 416  NLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVF 475

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
             Q  YR  + E+A PG+ V  + ATD D G N  +RYS+    V G G G        +F
Sbjct: 476  SQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSI----VSGNGLG--------WF 523

Query: 357  AVEELSGVVRVWRP--LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
             + E SG+V       LDRE  +   L + ARD G  P+V+  ++ + +LDVND +P   
Sbjct: 524  HISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKP--- 580

Query: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD-GSISLSLEG 473
            V    EG    V E A  G  +  +  +D D                LGD G++  SL+ 
Sbjct: 581  VFSQPEGYDVSVVENAPTGTELLMLRATDGD----------------LGDNGTVRFSLQE 624

Query: 474  GEGD---FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
             E D   F L P        L     LDRE +  Y LL++ATD GSPP S+   + + + 
Sbjct: 625  AETDRRSFRLDPVSGR----LSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLL 680

Query: 531  DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
            D+ND  P+F    Y A + E    G+ +  VSA+D D     +  ++Y++          
Sbjct: 681  DINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLG--TNGTVKYSI---------- 728

Query: 591  SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
                    +A     F ++++SG IST   LDRE + A +L++VA D G        +V+
Sbjct: 729  --------SAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVT 780

Query: 651  ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
            ITV D  DN P+F +  Y+  + E+  +G+    V+AS  D  L   I Y +  G    +
Sbjct: 781  ITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTG----D 834

Query: 711  APQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPV 770
                F I+   GQ+  +  IDRE + + Y L V A  GG ++    V + ++D+NDN P 
Sbjct: 835  QKGMFAINQVTGQLTTANVIDRE-EQSFYQLKVVAS-GGTVTGDTMVNITVKDLNDNSPH 892

Query: 771  FNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL 830
            F  +    ++ +  Q G  I    A D D G+ G V Y L   N  +LF I+   G I L
Sbjct: 893  FLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL-KQNPKNLFAINEKNGTISL 951

Query: 831  TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 890
              PL  + + +  + + A D G      +  +T+++         F++  Y   + E  P
Sbjct: 952  LGPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEP 1010

Query: 891  EDSPIGTVKAREPLNSSE-PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
             +S    V+A +  + +   I Y I+ G+ G  F I P  G +  +  LD E Q   VL 
Sbjct: 1011 VNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLM 1069

Query: 950  VQAQLGSAPACSSTEVNITVM--DVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 1007
            V A   +    S+T VN+TV+  DVNDN P F  T+      +    G+ +    A D+D
Sbjct: 1070 VVASDRAVEPLSAT-VNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKD 1128

Query: 1008 SGRNGLIRYSIASPQPGVFAIDRALGVL-----FLNGSLGAGEQREL-TLTLRAEDQGVH 1061
             G NG +RYS    QP  F +    G +     F   SL       + + T+ A DQG+ 
Sbjct: 1129 FGPNGEVRYSFEMVQPD-FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGI- 1186

Query: 1062 PQAALLVLTVVIEKRE---HSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118
            PQ      TV +  ++   ++P +  +   YQ  +SES + +TQ+L+  A  +       
Sbjct: 1187 PQPLKDQATVHVYMKDINDNAPKFLKDF--YQATISESAANLTQVLRVSASDVDEGNNGL 1244

Query: 1119 PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI 1178
             + YS+    +   F I   +G + L  + DYE+T  Y+  + A +       N + T+ 
Sbjct: 1245 -IHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQA-VDSGTIPLNSTCTLN 1302

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF-- 1236
            + + DENDN+P+F    LF+ V E+     ++  +TA D DSG N  L Y +        
Sbjct: 1303 IDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGT 1362

Query: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
            F ++PNTG +     LD E +  +++ +   D+G PPR++TM+V + V D NDN P FP 
Sbjct: 1363 FSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFP- 1421

Query: 1297 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
              PG ++   ++E  P+   V +V A DPD   N +++Y++    P
Sbjct: 1422 --PG-DIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMP 1464



 Score =  382 bits (982), Expect = e-105
 Identities = 357/1245 (28%), Positives = 567/1245 (45%), Gaps = 130/1245 (10%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
            F +   +G +    +LD E    YS V   +      L +   + I + D ND++P FP 
Sbjct: 1258 FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPK 1317

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
             +L +DV E    G       A D D+G  +   Y++   ++      G F         
Sbjct: 1318 STLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNN-----HGTF--------- 1363

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
                 + P + S      + L ++LD E  + ++L I A D GRP R+  +SV + V D 
Sbjct: 1364 ----SISPNTGS------IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDF 1413

Query: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
            NDNPP F   +   ++ E+   G  V  V A D D   NG + Y++  +Q+P        
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTI-IQQMPRGN----- 1467

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV---ATVRVSIAVLDV 406
                 +F ++E+ G +     +DRE     +L V+A D     E    A   V+I V D+
Sbjct: 1468 -----HFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDL 1522

Query: 407  NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
            NDN P    +F+++  +A     A  G  +  +  +D D      + A GE+   + +G 
Sbjct: 1523 NDNVP----MFISQNALA-ADPSAVIGSVLTTIMAADPD------EGANGEIEYEIINGD 1571

Query: 467  I-SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP--PLSTEE 523
              +  ++   GD  +     P              S+ +Y L++ ATD G      +TE 
Sbjct: 1572 TDTFIVDRYSGDLRVASALVP--------------SQLIYNLIVSATDLGPERRKSTTEL 1617

Query: 524  TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
            T++L+  D     P+F+Q  Y   + E    GT V+ + A  A   GS+ A + Y +V +
Sbjct: 1618 TIILQGLD----GPVFTQPKYITILKEGEPIGTNVISIEA--ASPRGSE-APVEYYIVSV 1670

Query: 584  SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV--AQDLGEP 641
                     + K V     G  F I   +G I T   LDRE    + L  V   +     
Sbjct: 1671 RC-------EEKTV-----GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAF 1718

Query: 642  PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
            P +    V IT+ D+NDN P+F   + + T+ E+   G   +Q+TA DAD G    + Y+
Sbjct: 1719 PRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYT 1778

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDL 761
            +  G     A  +FRIDP  G +  ++ +DRER  + Y LLV A D G  S+   + + +
Sbjct: 1779 IISG-----ADDSFRIDPESGDLIATRRLDRER-RSKYSLLVRA-DDGLQSSDMRINITV 1831

Query: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTI 821
             DVND+ P F+   Y   I ++T PG+ +  +LATD DSG+ G + Y +   +   +F +
Sbjct: 1832 SDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFL 1891

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            +  TG+  LT  L +       L V A+DGGG    I   V  +I      P  F    Y
Sbjct: 1892 NPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIR--VYFNILDVNDNPPIFSLNSY 1949

Query: 882  TFLVYEDVPEDSPI---GTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL 938
            +  + E++P  S +       A + +NS   + Y I+SGD  G+F++  + G ++  K L
Sbjct: 1950 STSLMENLPVGSTVLVFNVTDADDGINSQ--LTYSIASGDSLGQFTV-DKNGVLKVLKAL 2006

Query: 939  DHETQPVVVLTVQA----QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
            D E+Q    L VQ     Q+ ++   S+ +V+I ++DVNDN P FL +     I + TP 
Sbjct: 2007 DRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFL-SPKLTYIPENTPI 2065

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLR 1054
             T ++ A+A D DSG N  I Y++ +P    F+I    G + L G L   E    TLT+ 
Sbjct: 2066 DTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVV 2125

Query: 1055 AEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
            A D+G     ++  V+ +V++  +++P   F   +Y+VE++E+    T ++Q  A   G 
Sbjct: 2126 ATDKGQPSLSSSTEVVVMVLDINDNNP--IFAQALYKVEINENTLTGTDIIQVFAAD-GD 2182

Query: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
            +     +RY +     +  F I   TG I + +  D E T TY+  V A   + G     
Sbjct: 2183 EGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQA--TDRGSTPRT 2240

Query: 1174 ST-TVIVRVWDENDNSPTFLHDVLFLKVEES--PVPQGVIGKITAIDMDSGKNGQLLYFL 1230
             T TV + + D ND  P F      + V E+   +P+ ++ ++ A D D G N +L Y L
Sbjct: 2241 DTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTIL-QVVARDDDRGSNSKLSYVL 2299

Query: 1231 L--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
               ++   F ++  +GEL    +LDRE +    + +  TD GSP    T  + V V D+N
Sbjct: 2300 FGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVN 2358

Query: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEV 1333
            DN P F      K     + E  P    V  V A D D   NA +
Sbjct: 2359 DNVPTF----ASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI 2399



 Score =  372 bits (955), Expect = e-102
 Identities = 353/1248 (28%), Positives = 547/1248 (43%), Gaps = 141/1248 (11%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAAT---LLGAVVQVEIRVNDVNDHSPRFPLD 170
            D F + P++G +   RRLDRERR  YS +      L  + +++ I V+DVNDH+P+F   
Sbjct: 1785 DSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRP 1844

Query: 171  SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230
                D+ E + PG+     +A D D+G+     Y + +      D  G FF         
Sbjct: 1845 VYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE-----DDEDGIFF--------- 1890

Query: 231  LPSPLLPGSSSPLEPLDLV--LLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                        L P+  V  L R LD E    + L + A DGG    T  + V   +LD
Sbjct: 1891 ------------LNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTT--IRVYFNILD 1936

Query: 289  ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
             NDNPP+F  + Y  ++ E+   G+ V     TD D G N  + YS+         + G 
Sbjct: 1937 VNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI---------ASGD 1987

Query: 349  ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE---VATVRVSIAVLD 405
            +LG    F V++ +GV++V + LDRE+Q+++ LVV+  D    P     +T +VSI +LD
Sbjct: 1988 SLGQ---FTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLD 2043

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEAT------GELG 459
            VNDN P     FL+   +  + E       V +   +D D       E T       +  
Sbjct: 2044 VNDNPPT----FLSP-KLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFS 2098

Query: 460  VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
            +G  DG + L+                        G LDRE    Y L +VATD G P L
Sbjct: 2099 IGTIDGEVRLT------------------------GELDREEVSNYTLTVVATDKGQPSL 2134

Query: 520  STEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579
            S+   +++ V D+ND  P+F+Q  YK  ++E    GT ++ V A+D DE    +  +RY 
Sbjct: 2135 SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDE--GTNGQVRYG 2192

Query: 580  VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG 639
            +V                        F IDS +GAI+  + LDRE      L V A D G
Sbjct: 2193 IV-----------------NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRG 2235

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEH-APVGHCFLQVTASDADSGLYGFI 698
              P + T  VSI + D+ND  P+F    Y+  + E+   +    LQV A D D G    +
Sbjct: 2236 STPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKL 2295

Query: 699  EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAF 756
             Y L+ G        AF +    G++ V+Q +DRE     + L++ A D G   L+    
Sbjct: 2296 SYVLFGG----NEDNAFTLSA-SGELGVTQSLDRE-TKERFVLMITATDSGSPALTGTGT 2349

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            + V ++DVNDN P F    Y T+I ++   GT+++ V A+D D+     +   +I GN  
Sbjct: 2350 INVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIGGN-- 2405

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINA-DVTIHIFQTTLAPAE 875
            S FTI+ +TG I  +  L        +L+V   D G    + ++  V + +      P  
Sbjct: 2406 SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPR 2465

Query: 876  FE-RPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
            F+  P  T +    +P             +  +  + Y + SG    KF I P  G I  
Sbjct: 2466 FQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMA 2524

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
              PL+  ++    + V+   GS P   ST   +TV  VN      +R  ++  +     P
Sbjct: 2525 AGPLNGASEVTFSVHVK-DGGSFPKTDST--TVTVRFVNKADFPKVRAKEQTFMFPENQP 2581

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             ++  L       S R   + Y IAS   G  F ID+  G + ++  L   + ++  + +
Sbjct: 2582 VSS--LVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWI 2639

Query: 1054 RAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM-LQTQAHPL 1111
             A D G  P ++   L + V++  +++P   F+   +  E+ E+LSP   + +       
Sbjct: 2640 EARDGGFPPFSSYEKLDITVLDVNDNAP--IFKEDPFISEILENLSPRKILTVSAMDKDS 2697

Query: 1112 GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
            GP      L Y +        F I   TG I   R  D E    Y   + +   +    Q
Sbjct: 2698 GPN---GQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKS-SDKGSPSQ 2753

Query: 1172 NVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 1231
            + S  V++ + DENDN+P F         E SP+    + ++T  D D G N    Y ++
Sbjct: 2754 STSVKVMINILDENDNAPRFSQIFSAHVPENSPLGY-TVTRVTTSDEDIGINAISRYSIM 2812

Query: 1232 SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
                 F +NP+TG+++    L+RE    + + V   D G      +  V + VTDINDN 
Sbjct: 2813 DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNA 2869

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
            P F +       ++   E   +   VT VFA DPDEG+N +V Y + S
Sbjct: 2870 PRFSR----TSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKS 2913



 Score =  370 bits (949), Expect = e-102
 Identities = 344/1227 (28%), Positives = 535/1227 (43%), Gaps = 144/1227 (11%)

Query: 151  VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
            +QV + V D+ND+ P F     Q  V E +  G++     A D D G  +   Y L    
Sbjct: 234  LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL---- 289

Query: 211  DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
               +D   PF Q+   T          G  +  EPLD    R+        + L ++A D
Sbjct: 290  ---QDEGTPF-QMDPET----------GLITVREPLDFEARRQ--------YSLTVQAMD 327

Query: 271  GGRPRRTGLLSVELRVLDENDNPPV-----FEQDEYRAAVREDAQPGAEVCRVRATDRD- 324
             G P  TG     +++LD NDN PV     F      A+V E+AQ G  V  +  TD D 
Sbjct: 328  RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS 387

Query: 325  -----------LGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDR 373
                       LG N    + V++ +VP                      +++V   LDR
Sbjct: 388  PAANGNISVQILGGNEQRHFEVQSSKVPNLS-------------------LIKVASALDR 428

Query: 374  EAQAWHQLVVEARDGGAEPEVATV--RVSIAVL-----DVNDNRPAIHVLFLTEGGVARV 426
            E    + L V   D    P  A V  R S+A L     D+ND+ P    +F  +     +
Sbjct: 429  ERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPP----VFSQQVYRVNL 484

Query: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
            SE A PG YV+ +S +D D         +   G GLG   IS                  
Sbjct: 485  SEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEH---------------S 529

Query: 487  GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ-QHYK 545
            G+      G LDRE      L + A D G  P  +   L++ + D+ND+ P+FSQ + Y 
Sbjct: 530  GLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYD 589

Query: 546  ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
             SV E A  GT ++ + A+D D    D+  +R+++ +                      S
Sbjct: 590  VSVVENAPTGTELLMLRATDGDLG--DNGTVRFSLQEAETDRR----------------S 631

Query: 606  FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
            F +D  SG +STI +LDRE Q    L V+A DLG PP S+   +++++ D+NDN P+F+ 
Sbjct: 632  FRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYP 691

Query: 666  QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQIC 725
              Y A I E+ P G     V+A+D D G  G ++YS+  G  S      F+++   G I 
Sbjct: 692  VQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRS-----RFQVNAQSGVIS 746

Query: 726  VSQDIDRERDPATYDLLVEAKDGGGLSA--QAFVRVDLEDVNDNHPVFNPSTYVTSISDE 783
                +DRE   A Y L + A DGG L +  QA V + + D  DN PVF+   Y   + + 
Sbjct: 747  TRMALDREEKTA-YQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFEN 805

Query: 784  TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLS 843
               G  + +V A+  D  +   ++Y +  G+   +F I+  TG +     +   E +   
Sbjct: 806  VALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQ 863

Query: 844  LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP 903
            L V A  GG +T     ++T+           F +   +  V E+      I   KA +P
Sbjct: 864  LKVVA-SGGTVTGDTMVNITVKDLNDN--SPHFLQAIESVNVVENWQAGHSIFQAKAVDP 920

Query: 904  LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST 963
                  +       +    F+I+ + GTI    PLD       +  + + +G     SS 
Sbjct: 921  DEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSV 980

Query: 964  EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
             + + V DVNDN P F + S E+ +S++ P  +  +  +A D+DSG NG I Y+IA    
Sbjct: 981  ILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNT 1040

Query: 1024 G-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPS 1081
            G  F I    G L++   L    Q    L + A D+ V P +A + +TV++E   ++ P 
Sbjct: 1041 GDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPL 1099

Query: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGW 1141
            +   +  +  E  +        +       GP      +RYS E  +    F +   +G 
Sbjct: 1100 FNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPN---GEVRYSFE--MVQPDFELHAISGE 1154

Query: 1142 IYLRRQFDYES------TQTYNFRVFAWIPEDGFLQNVSTTVIVRVW--DENDNSPTFLH 1193
            I    QFD ES      T  ++F V A   + G  Q +     V V+  D NDN+P FL 
Sbjct: 1155 ITNTHQFDRESLMRRRGTAVFSFTVIA--TDQGIPQPLKDQATVHVYMKDINDNAPKFLK 1212

Query: 1194 DVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVA 1251
            D     + ES      + +++A D+D G NG + Y ++  ++ + F ++  +G++     
Sbjct: 1213 DFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGK 1272

Query: 1252 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311
            LD E    + + +   D G+ P N+T  + + + D NDN P FP+      L V VLE  
Sbjct: 1273 LDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPK----STLFVDVLENM 1328

Query: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
             +  LV++V A D D G+NA++ YS++
Sbjct: 1329 RIGELVSSVTATDSDSGDNADLYYSIT 1355



 Score =  355 bits (912), Expect = 1e-97
 Identities = 347/1245 (27%), Positives = 542/1245 (43%), Gaps = 140/1245 (11%)

Query: 123  GIIRTARRLDRERRDHYSFVA---------ATLLGAVVQVEIRVNDVNDHSPRFPLDSLQ 173
            G+++  + LDRE +  Y+ V          A+   +  QV I + DVND+ P F    L 
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT 2057

Query: 174  LDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPS 233
              + E +P  T      A DPD+G  S   YTL+       +P G  F +     G +  
Sbjct: 2058 Y-IPENTPIDTVVFKAQATDPDSGPNSYIEYTLL-------NPLGNKFSI-----GTIDG 2104

Query: 234  PLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNP 293
                         ++ L   LDREE + + L + A D G+P  +    V + VLD NDN 
Sbjct: 2105 -------------EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN 2151

Query: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
            P+F Q  Y+  + E+   G ++ +V A D D G NG VRY +    V G           
Sbjct: 2152 PIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGI----VNG--------NTN 2199

Query: 354  AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI 413
              F ++ ++G + V +PLDRE    + L V+A D G+ P   T  VSI +LD+ND  P  
Sbjct: 2200 QEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP-- 2257

Query: 414  HVLFLTEGGVARVSE--GARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSL 471
              +F        V E  G  P   +  V+  D  G                 +  +S  L
Sbjct: 2258 --VFELSPYSVNVPENLGTLPRTILQVVARDDDRG----------------SNSKLSYVL 2299

Query: 472  EGGEGD--FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRV 529
             GG  D  F L   G  G     V   LDRE+++ + L++ ATD+GSP L+   T+ + V
Sbjct: 2300 FGGNEDNAFTLSASGELG-----VTQSLDRETKERFVLMITATDSGSPALTGTGTINVIV 2354

Query: 530  ADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
             D+ND  P F+ + Y  ++ E A  GT V+ V+ASDAD +                    
Sbjct: 2355 DDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS-------------------- 2394

Query: 590  GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCL 648
               ++ ++        F I+  +G I T   LDRE ++   L VV  D G P PLS++  
Sbjct: 2395 ---KNAVIRIIGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTS 2451

Query: 649  VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLS 708
            V +TV DVNDN P F    Y   I      G     VT +DAD G    + YS     LS
Sbjct: 2452 VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-----LS 2506

Query: 709  YEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH 768
                + F IDP  G I  +  ++   +  T+   V  KDGG         V +  VN   
Sbjct: 2507 GRNSEKFHIDPLRGAIMAAGPLNGASE-VTFS--VHVKDGGSFPKTDSTTVTVRFVNKAD 2563

Query: 769  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGII 828
                 +   T +  E QP + ++  +      G    ++Y +  GN+ + F ID  TG +
Sbjct: 2564 FPKVRAKEQTFMFPENQPVSSLVTTITGSSLRG--EPMSYYIASGNLGNTFQIDQLTGQV 2621

Query: 829  YLTLPLSHLESTTLSLMVSAQDGG--GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 886
             ++ PL   +     + + A+DGG    ++    D+T+ +     AP   E P  + ++ 
Sbjct: 2622 SISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITV-LDVNDNAPIFKEDPFISEILE 2680

Query: 887  EDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 945
               P    I TV A +     +  + Y I +G++   FSI+   G IR+ +PLD E    
Sbjct: 2681 NLSPR--KILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSH 2738

Query: 946  VVLTVQ-AQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
             VLT++ +  GS    +S +V I ++D NDN P F +      + + +P G  +      
Sbjct: 2739 YVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIF-SAHVPENSPLGYTVTRVTTS 2797

Query: 1005 DRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 1064
            D D G N + RYSI       F I+ + G + ++  L   +     + + A D G     
Sbjct: 2798 DEDIGINAISRYSIMDASL-PFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVST 2856

Query: 1065 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL 1124
             + +    I       S T  +L    E++E  S +TQ+  T      P   ++   +  
Sbjct: 2857 DVTIFVTDINDNAPRFSRTSYYLDCP-ELTEIGSKVTQVFATD-----PDEGSNGQVFYF 2910

Query: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYE-----STQTYNFRVFAWIPEDGFLQNV--STTV 1177
              S  S  F I   TG I+ ++   Y+     S    N   F     D    ++   TTV
Sbjct: 2911 IKS-QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTV 2969

Query: 1178 IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAI-DMDSGKNGQLLYFLLSDGKF 1236
             + + D NDN+P FL    F  V ++      + ++TAI D D G N ++ YF+ +D   
Sbjct: 2970 TINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHL 3029

Query: 1237 --FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
              FK++ +TG +    +L  +   +  +TV   D+G+PP ++   V+++VT+ N + P F
Sbjct: 3030 GKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF 3089

Query: 1295 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             Q      +   + E   +  +V TV A+D D   N  + YS+SS
Sbjct: 3090 SQ----SHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISS 3130



 Score =  350 bits (899), Expect = 4e-96
 Identities = 348/1252 (27%), Positives = 529/1252 (42%), Gaps = 135/1252 (10%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPRFPL 169
            F V+  +G+I T   LDRE +  Y        G  +Q      V I V D  D+ P F  
Sbjct: 736  FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQ 795

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
             +    V E    G       A   D  L S   Y +        D  G  F +   T  
Sbjct: 796  VAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTG-----DQKG-MFAINQVTG- 846

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
                              L     +DREE + ++L++ A  G     TG   V + V D 
Sbjct: 847  -----------------QLTTANVIDREEQSFYQLKVVASGG---TVTGDTMVNITVKDL 886

Query: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
            NDN P F Q      V E+ Q G  + + +A D D G NG V YS++             
Sbjct: 887  NDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNP---------- 936

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
                  FA+ E +G + +  PLD  A ++ Q+ + A D G     ++V +++ V DVNDN
Sbjct: 937  ---KNLFAINEKNGTISLLGPLDVHAGSY-QIEILASDMGVPQLSSSVILTVYVHDVNDN 992

Query: 410  RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
             P    L         +SE         +V  SD      K+  A GE+   +       
Sbjct: 993  SPVFDQLSYE----VTLSESEPVNSRFFKVQASD------KDSGANGEIAYTIA------ 1036

Query: 470  SLEGGEGD-FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
              EG  GD F + P G      L ++  LDRE +D Y L++VA+D    PLS    + + 
Sbjct: 1037 --EGNTGDAFGIFPDGQ-----LYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVI 1089

Query: 529  VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
            + D+ND  PLF+  +Y     E    G+ V  VSA D D   +      + +VQ      
Sbjct: 1090 LEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQ------ 1143

Query: 589  LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREV------QEAVELKVVAQDLGEP- 641
                           P F + + SG I+     DRE              V+A D G P 
Sbjct: 1144 ---------------PDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQ 1188

Query: 642  PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
            PL     V + + D+NDN P F +  Y ATI+E A      L+V+ASD D G  G I YS
Sbjct: 1189 PLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYS 1248

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRV 759
            +  G       + F ID   GQ+ +   +D E  PA Y L+++A D G   L++   + +
Sbjct: 1249 IIKG----NEERQFAIDSTSGQVTLIGKLDYEATPA-YSLVIQAVDSGTIPLNSTCTLNI 1303

Query: 760  DLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF 819
            D+ D NDN P F  ST    + +  + G  + +V ATD DSG    + Y +   N    F
Sbjct: 1304 DILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTF 1363

Query: 820  TIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
            +I   TG I+L   L     +   L ++A+D G         V IH+      P  F   
Sbjct: 1364 SISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPG 1423

Query: 880  KYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYR-ISSGDLGGKFSIHPRLGTIRTRKP 937
                 + E++P  + + +V A +P  + +  + Y  I     G  F+I    GTI T   
Sbjct: 1424 DIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAE 1483

Query: 938  LDHETQPVVVLTVQAQLGSAP----ACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
            +D E   +  LTV+A   + P      +   V I V D+NDN P F+ + + +    +  
Sbjct: 1484 IDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI-SQNALAADPSAV 1542

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             G+ L    A D D G NG I Y I +     F +DR  G L +  +L    Q    L +
Sbjct: 1543 IGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIV 1601

Query: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
             A D G   + +   LT++++  +  P +T    +  ++  E +   T ++  +A    P
Sbjct: 1602 SATDLGPERRKSTTELTIILQGLD-GPVFTQPKYITILKEGEPIG--TNVISIEA--ASP 1656

Query: 1114 QRAASPLRYSL-----EPSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYNFRVFAWIPED 1167
            + + +P+ Y +     E      +F I  +TG I      D E     Y   V+A     
Sbjct: 1657 RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKST 1716

Query: 1168 GFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227
             F +     V + + D NDN P F  D+L L VEE+      I ++TA+D D G N  + 
Sbjct: 1717 AFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVT 1776

Query: 1228 YFLLSDG-KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
            Y ++S     F+++P +G+LI    LDRE R  + + V   D     +++ M + ++V+D
Sbjct: 1777 YTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD---GLQSSDMRINITVSD 1833

Query: 1287 INDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
            +ND+ P F + +   ++    + G     LV  + A D D G N E+TY V+
Sbjct: 1834 VNDHTPKFSRPVYSFDIPEDTIPGS----LVAAILATDDDSGVNGEITYIVN 1881



 Score =  340 bits (871), Expect = 7e-93
 Identities = 353/1262 (27%), Positives = 535/1262 (42%), Gaps = 150/1262 (11%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGA-----VVQVEIRVNDVNDHSPRFPL 169
            F + P +G + T   LDRE +  YS  V AT LG+     + ++ + + D+ND+SP F  
Sbjct: 632  FRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYP 691

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
                  + E  P G+      A DPD G   T  Y++          AG   + +     
Sbjct: 692  VQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSI---------SAGDRSRFQVNAQS 742

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
             + S  +                 LDREE  A++LQI A DGG  +      V + VLD 
Sbjct: 743  GVISTRMA----------------LDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDT 786

Query: 290  NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
             DNPPVF Q  Y   V E+   G  V  V A+  DL  N  + Y +      G       
Sbjct: 787  QDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTGDQKGM------ 838

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
                  FA+ +++G +     +DRE Q+++QL V A  G    +     V+I V D+NDN
Sbjct: 839  ------FAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTM---VNITVKDLNDN 889

Query: 410  RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
             P  H L   E     V E  + G  + +    D D      +   G +   L     +L
Sbjct: 890  SP--HFLQAIES--VNVVENWQAGHSIFQAKAVDPD------EGVNGMVLYSLKQNPKNL 939

Query: 470  -SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
             ++    G  +LL             GPLD  +   Y++ ++A+D G P LS+   L + 
Sbjct: 940  FAINEKNGTISLL-------------GPLDVHAGS-YQIEILASDMGVPQLSSSVILTVY 985

Query: 529  VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
            V D+ND  P+F Q  Y+ ++SE+    +    V ASD D   +    + YT+ +      
Sbjct: 986  VHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGE--IAYTIAE------ 1037

Query: 589  LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                          G +F I  + G +     LDRE+Q+   L VVA D    PLSAT  
Sbjct: 1038 -----------GNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVN 1085

Query: 649  VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLS 708
            V++ ++DVNDN P+F    Y     E    G    +V+A D D G  G + YS       
Sbjct: 1086 VTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYS------- 1138

Query: 709  YEAPQA-FRIDPHDGQICVSQDIDRE-----RDPATYDLLVEAKDGG---GLSAQAFVRV 759
            +E  Q  F +    G+I  +   DRE     R  A +   V A D G    L  QA V V
Sbjct: 1139 FEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198

Query: 760  DLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF 819
             ++D+NDN P F    Y  +IS+     T+++ V A+D D G  G + Y +I GN    F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258

Query: 820  TIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
             IDST+G + L   L +  +   SL++ A D G +       + I I         F  P
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSF--P 1316

Query: 880  KYTFLVYEDVPEDSPIGTVKAREPLNSSEP-----IFYRISSGDLGGKFSIHPRLGTIRT 934
            K T  V  DV E+  IG + +      S+      ++Y I+  +  G FSI P  G+I  
Sbjct: 1317 KSTLFV--DVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFL 1374

Query: 935  RKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
             K LD ETQ +  L + A+  G  P  S+  V I V D NDN P+F        I +  P
Sbjct: 1375 AKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIP 1434

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQP--GVFAIDRALGVLFLNGSLGAGEQRELTL 1051
             GT++    A D D+  NG + Y+I    P    F ID   G ++ N  +         L
Sbjct: 1435 IGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFEL 1494

Query: 1052 TLRAEDQGVHPQA---ALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 1107
            T++A DQ V  +    AL  +T+++ +  ++ P +     + Q  ++   S +   + T 
Sbjct: 1495 TVKANDQAVPIETRRYALKNVTILVTDLNDNVPMF-----ISQNALAADPSAVIGSVLTT 1549

Query: 1108 AHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
                 P   A+  + Y +    D+  F +  Y+G + +       S   YN  V A   +
Sbjct: 1550 IMAADPDEGANGEIEYEIING-DTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSA--TD 1605

Query: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
             G  +  STT +  +    D         + +  E  P+   VI    A     G    +
Sbjct: 1606 LGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA--SPRGSEAPV 1663

Query: 1227 LYFLLSD-------GKFFKMNPNTGELINWVALDREHRGH-HEMTVLVTDRGSP-PRNAT 1277
             Y+++S        G+ F +  +TG +     LDRE     + + V   ++ +  PR   
Sbjct: 1664 EYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQR 1723

Query: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
              V +++ DINDN P FP  +    +   + +G  +  L     A D DEG NA VTY++
Sbjct: 1724 AEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT----AMDADEGANALVTYTI 1779

Query: 1338 SS 1339
             S
Sbjct: 1780 IS 1781



 Score =  330 bits (846), Expect = 6e-90
 Identities = 347/1299 (26%), Positives = 553/1299 (42%), Gaps = 152/1299 (11%)

Query: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
            + E  P DT+V   +A  P +       + L      +PL + F +    G +R    LD
Sbjct: 2059 IPENTPIDTVVFKAQATDPDSGPNSYIEYTLL-----NPLGNKFSIGTIDGEVRLTGELD 2113

Query: 133  RERRDHYSF-VAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
            RE   +Y+  V AT      L +  +V + V D+ND++P F     +++++E +  GT  
Sbjct: 2114 REEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDI 2173

Query: 187  RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
                A D D G   T G                  Q+RY         ++ G+++    +
Sbjct: 2174 IQVFAADGDEG---TNG------------------QVRY--------GIVNGNTNQEFRI 2204

Query: 247  D-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
            D     + + + LDRE+   + L ++A D G   RT   +V + +LD ND  PVFE   Y
Sbjct: 2205 DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPY 2264

Query: 302  RAAVRED-AQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
               V E+       + +V A D D G N  + Y      V   G+   A   +A      
Sbjct: 2265 SVNVPENLGTLPRTILQVVARDDDRGSNSKLSY------VLFGGNEDNAFTLSA------ 2312

Query: 361  LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
             SG + V + LDRE +    L++ A D G+     T  +++ V DVNDN P     F ++
Sbjct: 2313 -SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT----FASK 2367

Query: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
                 + E A  G  V  V+ SDAD                    +  + + GG   F +
Sbjct: 2368 AYFTTIPEDAPTGTDVLLVNASDAD-----------------ASKNAVIRIIGGNSQFTI 2410

Query: 481  LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP-PLSTEETLLLRVADLNDQPPLF 539
                 P    +     LDRE++D Y L++V +DAGSP PLS+  ++L+ V D+ND PP F
Sbjct: 2411 ----NPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRF 2466

Query: 540  SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
                Y   +     PG+ V  V+ +DAD   +    L Y++                  +
Sbjct: 2467 QHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSE--LHYSL------------------S 2506

Query: 600  AECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDN 659
                  F ID   GAI     L+   +  V   V  +D G  P   T   ++TV  VN  
Sbjct: 2507 GRNSEKFHIDPLRGAIMAAGPLNGASE--VTFSVHVKDGGSFP--KTDSTTVTVRFVNKA 2562

Query: 660  E-PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRID 718
            + P    +       E+ PV      +T S         + Y +  G L       F+ID
Sbjct: 2563 DFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEP---MSYYIASGNLG----NTFQID 2615

Query: 719  PHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPSTY 776
               GQ+ +SQ +D E+    Y + +EA+DGG     ++ ++D+   DVNDN P+F    +
Sbjct: 2616 QLTGQVSISQPLDFEK-IQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPF 2674

Query: 777  VTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSH 836
            ++ I +   P  +I+ V A D+DSG  G + YE++ GN+ + F+I+  TG I    PL  
Sbjct: 2675 ISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDR 2733

Query: 837  LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIG 896
             + +   L + + D G  +   +  V I+I            P+++ +    VPE+SP+G
Sbjct: 2734 EKVSHYVLTIKSSDKGSPSQSTSVKVMINILD-----ENDNAPRFSQIFSAHVPENSPLG 2788

Query: 897  TVKAREPLNSSE---PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 953
                R   +  +       R S  D    F+I+P  G I   +PL+ E      + V A 
Sbjct: 2789 YTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848

Query: 954  LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
               +    ST+V I V D+NDN P F RTS  +   + T  G+ +    A D D G NG 
Sbjct: 2849 --DSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQ 2906

Query: 1014 IRYSIASPQPGVFAIDRALGVLF---------LNGSLGAGEQRELTLTLRAEDQGVHPQA 1064
            + Y I S Q   F I+   G +F         + G       R  +  + + D+G     
Sbjct: 2907 VFYFIKS-QSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRH-SFIVTSSDRGKPSLI 2964

Query: 1065 ALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 1123
            +   +T+ +++  +++P   F    Y   V++++   T++++  A         S + Y 
Sbjct: 2965 SETTVTINIVDSNDNAPQ--FLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYF 3022

Query: 1124 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWD 1183
            +        F +   TGWI +      +  Q +   V A    +  L +   TV + V +
Sbjct: 3023 ISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSS-QATVHITVTE 3081

Query: 1184 ENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNP 1241
            EN ++P F    +   + ES     ++  ++A D D+  NG + Y + S  +   F +N 
Sbjct: 3082 ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINS 3141

Query: 1242 NTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 1301
            +TG L    ALD E    HEMT+   D G   R    +V V+V D+NDN P F       
Sbjct: 3142 STGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF----LSD 3197

Query: 1302 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
            +    VLE  P    V  + A D D G NA + Y+V S+
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSS 3236



 Score =  327 bits (837), Expect = 6e-89
 Identities = 338/1328 (25%), Positives = 563/1328 (42%), Gaps = 172/1328 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATL-------LGAVVQVEIRVNDVNDHSP--- 165
            F ++P TG I T+  LDRE +D+Y+ V           L +   V + V DVND+ P   
Sbjct: 2408 FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467

Query: 166  --------------------------------------------RFPLDSLQLDVSELSP 181
                                                        +F +D L+  +    P
Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGP 2527

Query: 182  PGTAFRLPVA-HDPDAGLF-----STQGYTLVQPSDLPKDPAGP-FFQLRYRTPGPLPSP 234
               A  +  + H  D G F     +T     V  +D PK  A    F      P      
Sbjct: 2528 LNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVT 2587

Query: 235  LLPGSSSPLEPLDLVLL--------------------RRLDREEAAAHRLQIEAWDGGRP 274
             + GSS   EP+   +                     + LD E+   + + IEA DGG P
Sbjct: 2588 TITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 2647

Query: 275  RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
              +    +++ VLD NDN P+F++D + + + E+  P  ++  V A D+D GPNG + Y 
Sbjct: 2648 PFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYE 2706

Query: 335  VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
            +    +  +            F++   +G +R  RPLDRE  + + L +++ D G+  + 
Sbjct: 2707 IVNGNMENS------------FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQS 2754

Query: 395  ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
             +V+V I +LD NDN P    +F      A V E +  G  V RV+ SD       ED  
Sbjct: 2755 TSVKVMINILDENDNAPRFSQIFS-----AHVPENSPLGYTVTRVTTSD-------EDIG 2802

Query: 455  TGELG-VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
               +    + D S+  ++    GD             + +  PL+RE  D Y + + A D
Sbjct: 2803 INAISRYSIMDASLPFTINPSTGD-------------IVISRPLNREDTDRYRIRVSAHD 2849

Query: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            +G   +ST+ T+   V D+ND  P FS+  Y     E    G+ V  V A+D DE  +  
Sbjct: 2850 SGWT-VSTDVTIF--VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQ 2906

Query: 574  AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
             +  Y +   S    + +       T E      +  ++    +   ++R         V
Sbjct: 2907 VF--YFIKSQSEYFRINAT------TGEIFNKQILKYQNVTGFSNVNINRH-----SFIV 2953

Query: 634  VAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA-SDADS 692
             + D G+P L +   V+I + D NDN P F +  Y   + ++  VG   ++VTA  D D 
Sbjct: 2954 TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDF 3013

Query: 693  GLYGFIEYSLY-DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG- 750
            GL   +EY +  D  L       F++D   G I V+  +  + +   + + V AKD G  
Sbjct: 3014 GLNSEVEYFISNDNHLG-----KFKLDNDTGWISVASSLISDLNQ-NFFITVTAKDKGNP 3067

Query: 751  -LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE 809
             LS+QA V + + + N + P F+ S    +I +    G+ +  V A D+D+ + G + Y 
Sbjct: 3068 PLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYS 3127

Query: 810  LIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 869
            +  GN   +F I+S+TGI+ L   L +       + +SA DGG +       VT+++   
Sbjct: 3128 ISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDV 3187

Query: 870  TLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIF-YRISSGDLGGKFSIHPR 928
                  F    Y   V E+ P  + +  + A +  + +  +  Y + S D    F I P 
Sbjct: 3188 NDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPN 3246

Query: 929  LGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIR 987
             G I T+  LD ET+    LTV+A  +     CS   VNI +   N+  P F+       
Sbjct: 3247 TGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFE 3306

Query: 988  ISQTTPPGTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVLFLNGSLGAGEQ 1046
            IS+  P GT +    A DRD G +G + Y I  + +   F I++  G ++++G L   ++
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKE 3366

Query: 1047 RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106
              ++L + A++ G    A +  +TV +   + +    F   +Y V++SE +   T +   
Sbjct: 3367 ERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFV 3426

Query: 1107 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
             A       + S   Y +    ++  F I P TG I +  + D E+   YN  V A +  
Sbjct: 3427 SAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLA-VDS 3485

Query: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN-GQ 1225
                   S +++V + D NDN P  +  V   +V E+  P  ++  + + D D   N G 
Sbjct: 3486 GTPSATGSASLLVTLEDINDNGP--MLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGP 3543

Query: 1226 LLYFLLSDG---KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
              Y+LLS G    +F ++   G L     +DRE      ++V+  D G P  ++T  V++
Sbjct: 3544 FTYYLLSTGPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHI 3602

Query: 1283 SVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM----LVTTVFAKDPD--EGNNAEVTYS 1336
            +V D NDN        P +   V++      N+    ++ +V  +DPD  +  +  +T  
Sbjct: 3603 TVIDQNDN--------PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCSLTSG 3654

Query: 1337 VSSARPMP 1344
            V+S   +P
Sbjct: 3655 VTSLFSIP 3662



 Score =  323 bits (829), Expect = 5e-88
 Identities = 286/1034 (27%), Positives = 449/1034 (43%), Gaps = 75/1034 (7%)

Query: 354  AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI 413
            A FA+   +G +     +DRE+      V+      + P   T  V + V D+NDN P  
Sbjct: 79   ALFAINSSTGALYTTSTIDRESLPSD--VINLVVLSSAPTYPT-EVRVLVRDLNDNAP-- 133

Query: 414  HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG 473
              +F     V    E +  G  V   + +D+D      D  +  +  G   G   L    
Sbjct: 134  --VFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRL---- 187

Query: 474  GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
               D  L P G      L  +G LDRE    Y+LL+   D G P       + + V D+N
Sbjct: 188  ---DITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDIN 244

Query: 534  DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
            D PP+F   HY+A V E A  G+ V+ V+A+DADE    +A +RY +     P       
Sbjct: 245  DNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEG--TNADIRYRLQDEGTP------- 295

Query: 594  SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
                        F +D E+G I+    LD E +    L V A D G P L+      I +
Sbjct: 296  ------------FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQL 343

Query: 654  DDVNDNEPIFWRQVYNAT-----IAEHAPVGHCFLQVTASDADS-GLYGFIEYSLYDGFL 707
             DVNDN+P+   + + AT     + E+A VG     +T +DADS    G I   +  G  
Sbjct: 344  LDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNE 403

Query: 708  SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVR--------- 758
                       P+   I V+  +DRER P+ Y+L V   D  G    A V+         
Sbjct: 404  QRHFEVQSSKVPNLSLIKVASALDRERIPS-YNLTVSVSDNYGAPPGAAVQARSSVASLV 462

Query: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
            + + D+ND+ PVF+   Y  ++S+E  PG+ +  + ATD DSG+   + Y ++ GN    
Sbjct: 463  IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGW 522

Query: 819  FTIDSTTGIIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
            F I   +G++       L    ++ + L +SA+D G    V  A + + +         F
Sbjct: 523  FHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVF 582

Query: 877  ERPK-YTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGK-FSIHPRLGTIR 933
             +P+ Y   V E+ P  + +  ++A +  L  +  + + +   +   + F + P  G + 
Sbjct: 583  SQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLS 642

Query: 934  TRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
            T   LD E Q    L V A  LGS P  S   +N++++D+NDN P F        I +  
Sbjct: 643  TISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENE 702

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 1052
            P G+ +    A D D G NG ++YSI++     F ++   GV+    +L   E+    L 
Sbjct: 703  PGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQ 762

Query: 1053 LRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
            + A D G    P  A++ +TV ++ +++ P   F  + Y   V E+++    +    A  
Sbjct: 763  IVATDGGNLQSPNQAIVTITV-LDTQDNPP--VFSQVAYSFVVFENVALGYHVGSVSAST 819

Query: 1111 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 1170
            +      S + Y +       MF I   TG +      D E    Y  +V A     G  
Sbjct: 820  MDLN---SNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA----SGGT 872

Query: 1171 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230
                T V + V D NDNSP FL  +  + V E+      I +  A+D D G NG +LY L
Sbjct: 873  VTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL 932

Query: 1231 LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIND 1289
              + K  F +N   G +     LD  H G +++ +L +D G P  ++++ + V V D+ND
Sbjct: 933  KQNPKNLFAINEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVND 991

Query: 1290 NRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKT 1349
            N P F Q        V + E +PVN     V A D D G N E+ Y+++        G  
Sbjct: 992  NSPVFDQL----SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIF 1047

Query: 1350 AFGKQSCKKQTNKQ 1363
              G+   K + +++
Sbjct: 1048 PDGQLYIKSELDRE 1061



 Score =  283 bits (723), Expect = 1e-75
 Identities = 285/1065 (26%), Positives = 463/1065 (43%), Gaps = 126/1065 (11%)

Query: 54   VWLWAASG-----SSAQLFNLT-LSVDEGLP---PDTLVGDIRAGLP--------AAQQQ 96
            VW+ A  G     SS +  ++T L V++  P    D  + +I   L         A  + 
Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKD 2696

Query: 97   EGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHY------SFVAATLLGAV 150
             G    L  +  +  + + F ++  TG IR+ R LDRE+  HY      S   +      
Sbjct: 2697 SGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTS 2756

Query: 151  VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
            V+V I + D ND++PRF        V E SP G         D D G+ +   Y+++  S
Sbjct: 2757 VKVMINILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDAS 2815

Query: 211  DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
                                LP  + P +       D+V+ R L+RE+   +R+++ A D
Sbjct: 2816 --------------------LPFTINPSTG------DIVISRPLNREDTDRYRIRVSAHD 2849

Query: 271  GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF 330
             G    T    V + V D NDN P F +  Y     E  + G++V +V ATD D G NG 
Sbjct: 2850 SGWTVST---DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQ 2906

Query: 331  VRYSVRAR-QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG 389
            V Y ++++ +     +  G + +      + ++G   V   ++R     H  +V + D G
Sbjct: 2907 VFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNV--NINR-----HSFIVTSSDRG 2959

Query: 390  AEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWE 449
                ++   V+I ++D NDN P     FL       V++  + G  + RV+  D D D+ 
Sbjct: 2960 KPSLISETTVTINIVDSNDNAPQ----FLKSKYFTPVTKNVKVGTKLIRVTAID-DKDFG 3014

Query: 450  KEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLL 509
               E    +      G   L  + G               ++ V   L  +    + + +
Sbjct: 3015 LNSEVEYFISNDNHLGKFKLDNDTG---------------WISVASSLISDLNQNFFITV 3059

Query: 510  VATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEA 569
             A D G+PPLS++ T+ + V + N   P FSQ H  A++ E+ + G++V  VSA D D A
Sbjct: 3060 TAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAA 3119

Query: 570  GSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV 629
                               +  L    + +      FAI+S +G ++  + LD E+ +  
Sbjct: 3120 -------------------MNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKH 3160

Query: 630  ELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASD 689
            E+ + A D G    +  C V++ V DVNDN P+F    Y  T+ E+AP G   + + A+D
Sbjct: 3161 EMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATD 3220

Query: 690  ADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG 749
            ADSG    I Y++            F IDP+ G I     +D E    +Y L V+A +  
Sbjct: 3221 ADSGTNAVIAYTVQS-----SDSDLFVIDPNTGVITTQGFLDFE-TKQSYHLTVKAFNVP 3274

Query: 750  GLSAQAF--VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVA 807
                 +F  V + L+  N+  P F    Y   IS+    GT +  V A+D+D G  G V 
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVH 3334

Query: 808  YELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
            Y +   +    F I+  TG IY++  L   +   +SL V A++ G +      +VT+++ 
Sbjct: 3335 YLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNV- 3393

Query: 868  QTTLAPAEFERPKYTFLVYE-DVPEDSPIGT----VKA--REPLNSSEPIFYRISSGDLG 920
              T+  A  + P +T  +Y   + E  PIGT    V A   + + S     Y I SG+  
Sbjct: 3394 --TVLDAN-DPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNEN 3450

Query: 921  GKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAF 979
            G FSI+P+ G I     LD ET P+  L+V A   G+  A  S  + +T+ D+NDN P  
Sbjct: 3451 GAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP-- 3508

Query: 980  LRTSDEIRISQTTPPGTALYLARAEDRDSGRN-GLIRYSIAS--PQPGVFAIDRALGVLF 1036
            + T  E  + +   PGT +   ++ D D   N G   Y + S  P    F++  A GVL 
Sbjct: 3509 MLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTA-GVLS 3567

Query: 1037 LNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPS 1081
                +   +  +  L++  +D GV   ++   + + +  +  +PS
Sbjct: 3568 TTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPS 3612



 Score =  266 bits (680), Expect = 1e-70
 Identities = 338/1309 (25%), Positives = 526/1309 (40%), Gaps = 143/1309 (10%)

Query: 40   GARTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGS 99
            G   + S + +++HV  +  +  S    ++  S+ E +P  T V  + A  P A      
Sbjct: 1396 GRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQL 1455

Query: 100  GFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAA---------TLLGAV 150
             + + +     P  + F +    G I T   +DRE  + +              T   A+
Sbjct: 1456 SYTIIQQM---PRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYAL 1512

Query: 151  VQVEIRVNDVNDHSPRF-PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQP 209
              V I V D+ND+ P F   ++L  D S +   G+     +A DPD G      Y ++  
Sbjct: 1513 KNVTILVTDLNDNVPMFISQNALAADPSAVI--GSVLTTIMAADPDEGANGEIEYEII-- 1568

Query: 210  SDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAW 269
                      F   RY     + S L+P                        + L + A 
Sbjct: 1569 ----NGDTDTFIVDRYSGDLRVASALVPSQ--------------------LIYNLIVSAT 1604

Query: 270  DGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNG 329
            D G  RR    + EL ++ +  + PVF Q +Y   ++E    G  V  + A     G   
Sbjct: 1605 DLGPERRKS--TTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAAS-PRGSEA 1661

Query: 330  FVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQL--VVEARD 387
             V Y + + +      G         F +   +G+++    LDRE  A   L  V     
Sbjct: 1662 PVEYYIVSVRCEEKTVG-------RLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEK 1714

Query: 388  GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447
              A P      V I + D+NDN P    +F T+     V E    G  + +++  DAD  
Sbjct: 1715 STAFPRTQRAEVEITLQDINDNPP----VFPTDMLDLTVEENIGDGSKIMQLTAMDAD-- 1768

Query: 448  WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507
             E  +       +   D S  +  E G+               L     LDRE R  Y L
Sbjct: 1769 -EGANALVTYTIISGADDSFRIDPESGD---------------LIATRRLDRERRSKYSL 1812

Query: 508  LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
            L+ A D      S++  + + V+D+ND  P FS+  Y   + E   PG++V  + A+D D
Sbjct: 1813 LVRADDGLQ---SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDD 1869

Query: 568  EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
               +                      + +V+  +    F ++  +G  +  R LD EVQ+
Sbjct: 1870 SGVNGEI-------------------TYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQ 1910

Query: 628  AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
               L V A+D G      T  V   + DVNDN PIF    Y+ ++ E+ PVG   L    
Sbjct: 1911 YYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNV 1968

Query: 688  SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
            +DAD G+   + YS+  G    ++   F +D  +G + V + +DRE   + Y+L+V+  D
Sbjct: 1969 TDADDGINSQLTYSIASG----DSLGQFTVD-KNGVLKVLKALDRE-SQSFYNLVVQVHD 2022

Query: 748  GGGLSAQAF-----VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGI 802
               + A  F     V + L DVNDN P F  S  +T I + T   T +    ATD DSG 
Sbjct: 2023 LPQIPASRFTSTAQVSIILLDVNDNPPTF-LSPKLTYIPENTPIDTVVFKAQATDPDSGP 2081

Query: 803  YGTVAYELIP--GNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINA 860
               + Y L+   GN  S+ TID   G + LT  L   E +  +L V A D G  +   + 
Sbjct: 2082 NSYIEYTLLNPLGNKFSIGTID---GEVRLTGELDREEVSNYTLTVVATDKGQPSLSSST 2138

Query: 861  DVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDL 919
            +V + +         F +  Y   + E+    + I  V A +    ++  + Y I +G+ 
Sbjct: 2139 EVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNT 2198

Query: 920  GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPA 978
              +F I    G I   KPLD E  P   LTVQA   GS P   ++ V+I ++D+ND  P 
Sbjct: 2199 NQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPV 2258

Query: 979  FLRTSDEIRISQT--TPPGTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVL 1035
            F  +   + + +   T P T L +  A D D G N  + Y +    +   F +  A G L
Sbjct: 2259 FELSPYSVNVPENLGTLPRTILQVV-ARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGEL 2316

Query: 1036 FLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVS 1094
             +  SL    +    L + A D G         + V+++   ++ P  TF    Y   + 
Sbjct: 2317 GVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVP--TFASKAYFTTIP 2374

Query: 1095 ESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQ 1154
            E     T +L   A      + A      +     ++ F I P TG I      D E+  
Sbjct: 2375 EDAPTGTDVLLVNASDADASKNA-----VIRIIGGNSQFTINPSTGQIITSALLDRETKD 2429

Query: 1155 TYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKIT 1214
             Y   V           + ST+V+V V D NDN P F H      +    +P   +  +T
Sbjct: 2430 NYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVT 2489

Query: 1215 AIDMDSGKNGQLLYFLLS-DGKFFKMNPNTGELINWVALDREHRGHHEMT--VLVTDRGS 1271
              D D G N +L Y L   + + F ++P  G ++    L+    G  E+T  V V D GS
Sbjct: 2490 VTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLN----GASEVTFSVHVKDGGS 2545

Query: 1272 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
             P+  +  V V       N+  FP+ +  KE      E QPV+ LVTT+
Sbjct: 2546 FPKTDSTTVTVRFV----NKADFPK-VRAKEQTFMFPENQPVSSLVTTI 2589



 Score =  176 bits (447), Expect = 1e-43
 Identities = 187/670 (27%), Positives = 284/670 (42%), Gaps = 55/670 (8%)

Query: 710  EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
            E+   F I+   G +  +  IDRE  P+    LV          +  VRV + D+NDN P
Sbjct: 76   ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTE--VRVLVRDLNDNAP 133

Query: 770  VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTV--AYELIPGNVSSLFTIDSTTG- 826
            VF   + V +  +++  G ++I   ATD D G  G    +Y +I GN +  F +D T   
Sbjct: 134  VFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNP 193

Query: 827  -----IIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
                  ++L     L    +    L+V  +D G         V + +      P  F   
Sbjct: 194  SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSS 253

Query: 880  KYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPL 938
             Y   V ED    S +  V A +    ++  I YR+   D G  F + P  G I  R+PL
Sbjct: 254  HYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVREPL 311

Query: 939  DHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPA-----FLRTSDEIRISQTT 992
            D E +    LTVQA     P+ +   E  I ++DVNDN P      F  TS    + +  
Sbjct: 312  DFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENA 371

Query: 993  PPGTALYLARAEDRDS-GRNGLIRYSI-ASPQPGVFAIDRA----LGVLFLNGSLGAGEQ 1046
              GT + L    D DS   NG I   I    +   F +  +    L ++ +  +L     
Sbjct: 372  QVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERI 431

Query: 1047 RELTLTLRAEDQ-----GVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLS 1098
                LT+   D      G   QA   V ++VI   +  +H P   F   VY+V +SE   
Sbjct: 432  PSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPP--VFSQQVYRVNLSEEAP 489

Query: 1099 PMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
            P + +    A   G     + LRYS+        F I  ++G +        +       
Sbjct: 490  PGSYVSGISATD-GDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQI 548

Query: 1159 RVFAWIPEDGFLQNVS-TTVIVRVWDENDNSPTFL----HDVLFLKVEESPVPQGVIGKI 1213
             +     + G    VS   ++V + D ND  P F     +DV    VE +P    ++  +
Sbjct: 549  VLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSV--VENAPTGTELL-ML 605

Query: 1214 TAIDMDSGKNGQLLYFLL---SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRG 1270
             A D D G NG + + L    +D + F+++P +G L    +LDRE +  + + VL TD G
Sbjct: 606  RATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665

Query: 1271 SPPRNATMAVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329
            SPP+++   + VS+ DINDN P F+P      +    + E +P    +TTV A DPD G 
Sbjct: 666  SPPQSSMARINVSLLDINDNSPVFYPV-----QYFAHIKENEPGGSYITTVSATDPDLGT 720

Query: 1330 NAEVTYSVSS 1339
            N  V YS+S+
Sbjct: 721  NGTVKYSISA 730



 Score =  175 bits (444), Expect = 2e-43
 Identities = 208/777 (26%), Positives = 315/777 (40%), Gaps = 113/777 (14%)

Query: 101  FFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATL-------LGAVVQV 153
            +F+S D+     L  F +  DTG I  A  L  +   ++ F+  T        L +   V
Sbjct: 3021 YFISNDNH----LGKFKLDNDTGWISVASSLISDLNQNF-FITVTAKDKGNPPLSSQATV 3075

Query: 154  EIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLP 213
             I V + N H+P F    +   + E    G+  R   A D DA +     Y++       
Sbjct: 3076 HITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI------- 3128

Query: 214  KDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
                         + G         SS+ +    L L + LD E    H + I A DGG 
Sbjct: 3129 -------------SSGNEEGIFAINSSTGI----LTLAKALDYELCQKHEMTISAIDGGW 3171

Query: 274  PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
              RTG  SV + V+D NDN PVF  D+Y   V E+A  G  V  + ATD D G N  + Y
Sbjct: 3172 VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAY 3231

Query: 334  SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
            +V++              D+  F ++  +GV+     LD E +  + L V+A +   E  
Sbjct: 3232 TVQS-------------SDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEER 3278

Query: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
             +   V+I +   N+  P     F+++     +SE A  G  V  V  SD D        
Sbjct: 3279 CSFATVNIQLKGTNEYVPR----FVSKLYYFEISEAAPKGTIVGEVFASDRD-------- 3326

Query: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
                LG    DG +   + G             G  +  V G LDRE  +   L ++A +
Sbjct: 3327 ----LGT---DGEVHYLIFGNSRKKGFQINKKTGQIY--VSGILDREKEERVSLKVLAKN 3377

Query: 514  AGSPPLS--TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGS 571
             GS   +   E T+ + V D ND PP+F+   Y   +SE    GT V +VSA D+D   S
Sbjct: 3378 FGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPS 3436

Query: 572  DHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVEL 631
               W R+               S  + +     +F+I+ ++G I+    LDRE      L
Sbjct: 3437 ---WSRF---------------SYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNL 3478

Query: 632  KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
             V+A D G P  + +  + +T++D+NDN P+    V    + E+   G   + + ++D D
Sbjct: 3479 SVLAVDSGTPSATGSASLLVTLEDINDNGPML--TVSEGEVMENKRPGTLVMTLQSTDPD 3536

Query: 692  --SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG 749
                   F  Y L  G     A   F +    G +  +++IDRE+  A + L V  KD G
Sbjct: 3537 LPPNQGPFTYYLLSTG----PATSYFSLST-AGVLSTTREIDREQ-IADFYLSVVTKDSG 3590

Query: 750  --GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVA 807
               +S+   V + + D NDN           +      PG  + +V    QD  +  +  
Sbjct: 3591 VPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSV--KPQDPDVLDSFH 3648

Query: 808  YELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST--TLSLMVSAQDGGGLTAVINADV 862
              L  G V+SLF+I   T  +      S   ST  T  L V + DG   T   N  V
Sbjct: 3649 CSLTSG-VTSLFSIPGGTCDLN-----SQPRSTDGTFDLTVLSNDGVHSTVTSNIRV 3699


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  394 bits (1013), Expect = e-109
 Identities = 367/1253 (29%), Positives = 547/1253 (43%), Gaps = 139/1253 (11%)

Query: 114  DDFHVHPDTGIIRTAR-RLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPR 166
            D FH+    G+++T     DRE++D +            Q      V + + DVND+ P+
Sbjct: 2010 DMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPK 2069

Query: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
            F        + + + PG       A D D G      Y   +           +F++   
Sbjct: 2070 FKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY--------TYFRI--- 2118

Query: 227  TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
                   P L G  S  +P D   L +        + L++ A DGG P        E+ V
Sbjct: 2119 ------DPYL-GDISLKKPFDYQALNK--------YHLKVIARDGGTPSLQS--EEEVLV 2161

Query: 287  LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF-VRYSVRARQVPGAGS 345
               N + P+F+   Y+  V E+      +   +A      P G  + Y++   +      
Sbjct: 2162 TVRNKSNPLFQSPYYKVRVPENITLYTPILHTQAR----SPEGLRLIYNIVEEE------ 2211

Query: 346  GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
                      F  +  +GV+ V  PLD E++  H   V A D  A    +   V + V D
Sbjct: 2212 ------PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATD-TALGSFSEATVEVLVED 2264

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
            VNDN P    L  T      +SEG      V ++  SD D    +  + + ++     D 
Sbjct: 2265 VNDNPPTFSQLVYT----TSISEGLPAQTPVIQLLASDQDSG--RNRDVSYQIVEDGSDV 2318

Query: 466  SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
            S    + G  G+ + +               LD E++  + + + A D G PPL+ E  +
Sbjct: 2319 SKFFQINGSTGEMSTVQ-------------ELDYEAQQHFHVKVRAMDKGDPPLTGETLV 2365

Query: 526  LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
            ++ V+D+ND PP F Q  Y+A+VSE A  G +V+ V A D D    D + L Y +     
Sbjct: 2366 VVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPD--SRDTSRLEYLI----- 2418

Query: 586  PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
               L   Q +          F I+S SG IS      + +  +  L+V A D       A
Sbjct: 2419 ---LSGNQDR---------HFFINSSSGIISMFNLCKKHLDSSYNLRVGASD---GVFRA 2463

Query: 646  TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
            T  V I   + N   P F + +Y A +AE+A VG   + + A D DSG YG I+Y++   
Sbjct: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI--- 2520

Query: 706  FLSYEAPQAFRIDPHDGQICVSQDIDRERD-PATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
             ++  A + F I+P +GQI   Q +DRE        + V A+DGGG  A   V++ L D 
Sbjct: 2521 -INKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDE 2578

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN-VSSLFTIDS 823
            NDN P F  S Y  SI       + +I VLA D D G    V Y + P + V  +  I+ 
Sbjct: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINP 2638

Query: 824  TTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
             TG++ +   L  LE+ TL   + AQDGG         V + +    ++  +F  P YTF
Sbjct: 2639 VTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTF 2698

Query: 884  LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSG-----DLGGKFSIHPRLGTIRTRKPL 938
               ED+PE S IG VKA   + + +P+ Y +  G     +  G FS+ P  G I+ RKP+
Sbjct: 2699 SAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPM 2755

Query: 939  DHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
            DHE+  +  + V A  L +    S   VNI V DVNDN P F     +  +++  P GT+
Sbjct: 2756 DHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTS 2815

Query: 998  LYLARAEDRDSGRNGLIRYSIASPQPG-----VFAIDRALGVLFLNGSLGAGEQRELTLT 1052
            +    A D+D+GR+G + Y + S  PG     +FAID   G +     L     +     
Sbjct: 2816 VIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFH 2874

Query: 1053 LRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQTQA 1108
            + A D G  +   +  LV   + ++ +++P +  E   Y+  V E+  P  +   L+T  
Sbjct: 2875 VVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEE--YRGSVVENSEPGELVATLKTLD 2932

Query: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPY-TGW-IYLRRQFDYESTQTYNFRVFAWIPE 1166
              +  Q     +   +        FGI      W I  R+  D E T  Y  RV A    
Sbjct: 2933 ADISEQN--RQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTA---S 2987

Query: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
            DG  Q  S TV + V D NDNSP     +   KV E   P   I K++A D+D+  N Q+
Sbjct: 2988 DGKFQ-ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQI 3046

Query: 1227 LYFLLSDGKF-FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 1285
             Y L   G   FK++P+TGEL    ALDRE +    +    TD G   R+    + + V 
Sbjct: 3047 TYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGG--RSCQADITLHVE 3104

Query: 1286 DINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            D+NDN P FFP         V V +   V   V  VFA+DPD+G NA+V YS+
Sbjct: 3105 DVNDNAPRFFP-----SHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL 3152



 Score =  340 bits (872), Expect = 5e-93
 Identities = 370/1317 (28%), Positives = 564/1317 (42%), Gaps = 169/1317 (12%)

Query: 67   FNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIR 126
            F  ++ V E +P +T +  + A  P A       + +++ +++      F +  +TG++ 
Sbjct: 718  FPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC----FDIELETGLLT 773

Query: 127  TARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVNDVNDHSPRFPLDSLQLDVSELS 180
             A  LD E  + Y   V    LG   +     + + V D ND++PRFP    QL +SE +
Sbjct: 774  VAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDT 833

Query: 181  PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
              GT        D D+       YTL+ P++                             
Sbjct: 834  EVGTTIAELTTKDADSEDNGRVRYTLLSPTE----------------------------K 865

Query: 241  SPLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRR----TGLLSVELRVLDENDNPP 294
              L PL  +LV+   LDRE    + L++EA D  +P +      +  + + + D NDN P
Sbjct: 866  FSLHPLTGELVVTGHLDRESEPRYILKVEARD--QPSKGHQLFSVTDLIITLEDVNDNSP 923

Query: 295  VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
                +  R  V ED  PG  +  + A+D DLGP G VRY +            GA G   
Sbjct: 924  QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLM----------DGAHGT-- 971

Query: 355  YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDN-RPA 412
             F V+ ++G + + R LD E +A + L + A DGG      T+  V + VLDVN+N  P 
Sbjct: 972  -FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPP 1030

Query: 413  IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
                F+ +G   +V E +  G  V  V+  D D               GL DG +   L 
Sbjct: 1031 HFASFVHQG---QVQENSPSGTQVIVVAAQDDDS--------------GL-DGELQYFLR 1072

Query: 473  GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
             G G  A       G+  +    PLDRE    Y L ++A D GS PLS+   + + V D 
Sbjct: 1073 AGTGLAAFSINQDTGM--IQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDA 1130

Query: 533  NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
            ND PP  SQ  +  S+ E A  GT V+ + A D D +                    G L
Sbjct: 1131 NDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK------------------GKL 1172

Query: 593  QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT 652
               +      G  F I   +G +ST + LDRE ++   L+V   D GEP L +T  V + 
Sbjct: 1173 TFNITSGNYMG-FFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVG 1231

Query: 653  VDDVNDNEPIFWRQVYNATIAEH-APVG-HCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
            + DVNDN PIF  +++N  + E  +PV      ++ ASD D GL G + YS+ D      
Sbjct: 1232 ILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIED-----S 1286

Query: 711  APQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAKDGGGLSAQAFVRVDLEDVNDNHP 769
              +AF ID   G +  S           Y++L ++A D G     A VR+ +E +    P
Sbjct: 1287 DEEAFSIDLVTGVVSSSSTF----TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRP 1342

Query: 770  VFNP----STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTT 825
               P     TY +    ET P   ++ V++ +   G++    + +  G+    F I+ TT
Sbjct: 1343 SSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFW---FNISGGDKDMDFDIEKTT 1399

Query: 826  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
            G I +  PL     +  +L V   DG    A       +HIF   +A     RP++    
Sbjct: 1400 GSIVIARPLDTRRRSNYNLTVEVTDGSRTIA-----TQVHIFM--IANINHHRPQFLETR 1452

Query: 886  YE-DVPEDSPIGT----VKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRKPL 938
            YE  VP+D+  G     V+A +       I+    S D G    F + P  G + T   L
Sbjct: 1453 YEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKL 1512

Query: 939  DHETQPVV-VLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            D  + P    LTV  +    P   +   V I V D N + P F +   E  +  T  PGT
Sbjct: 1513 DLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGT 1572

Query: 997  ALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 1055
             L   RA D D G N  + YS +     G F I+  LG++ L   L        TLT++A
Sbjct: 1573 ELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKA 1632

Query: 1056 EDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQR 1115
            EDQG  PQ   L   ++        +  F    Y VE+ ES+   + +L   A       
Sbjct: 1633 EDQG-SPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA------M 1685

Query: 1116 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST 1175
            + S + Y L       +F +  Y+G I  +++ D+E   +Y  ++        F      
Sbjct: 1686 SPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAF---TDV 1742

Query: 1176 TVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGK------ITAIDMDSGKNGQLLY 1228
             V+V + DENDN+P FL      ++ E +P+   ++ K      I A D D   N  L+Y
Sbjct: 1743 MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802

Query: 1229 FLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSP----PRNATMAVYV 1282
             +L     KFFK++P+ G L     +D E     +  V V D+GSP    PR A   V +
Sbjct: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPA--QVII 1860

Query: 1283 SVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             V D+ND+ P F      ++++   + G P++  +  +  +  DE  ++EV YS+ +
Sbjct: 1861 HVRDVNDSPPRF-----SEQIYEVAIVG-PIHPGMELLMVRASDE--DSEVNYSIKT 1909



 Score =  325 bits (834), Expect = 1e-88
 Identities = 352/1297 (27%), Positives = 543/1297 (41%), Gaps = 183/1297 (14%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG-AVVQVEIRVNDVNDHSPRFPLDSLQL 174
            F ++  TG+I T + +D   R HY     T  G A   V I + D N+H+P F   S   
Sbjct: 406  FKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSYDG 465

Query: 175  DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
             + E  PPGT+     A D D G      Y++  P  LP       F +          P
Sbjct: 466  TLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-------FSI---------DP 509

Query: 235  LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNP 293
             L G  S  +P+D  L++R+       +  ++ A D G P RR   +S+ L++ + NDN 
Sbjct: 510  YL-GIISTSKPMDYELMKRI-------YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561

Query: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
            P+FE+     ++R+D   G  +  + A D D   N  ++Y +    V G         + 
Sbjct: 562  PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEI----VSG--------NEL 607

Query: 354  AYFAVEELSGVVRVWRP---LDREAQAWHQLVVEARDGG--AEPEVATVRV--------- 399
             YF +   SGV+ + RP   L       + L + A DG   A P    + V         
Sbjct: 608  EYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVP 667

Query: 400  ---------------------------------SIAVLDVNDNRPAIHVLFLTEGGVARV 426
                                             S++   +N   P     F        V
Sbjct: 668  VTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQS---IDV 724

Query: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
             E       +AR++ +D D  +       G+L   + DG+     E G  D  L  G   
Sbjct: 725  LESVPINTPLARLAATDPDAGF------NGKLVYVIADGN-----EEGCFDIELETG--- 770

Query: 487  GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
                L V  PLD E+ + Y L +   D G+P  S+ + L + V D ND  P F    Y+ 
Sbjct: 771  ---LLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQL 827

Query: 547  SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
            ++SE    GT +  ++  DAD    D+  +RYT++  +   +L  L  ++V T       
Sbjct: 828  TISEDTEVGTTIAELTTKDAD--SEDNGRVRYTLLSPTEKFSLHPLTGELVVTGH----- 880

Query: 607  AIDSESGAISTIRTLDREVQEAVELKVVAQD---LGEPPLSATCLVSITVDDVNDNEPIF 663
                          LDRE +    LKV A+D    G    S T L+ IT++DVNDN P  
Sbjct: 881  --------------LDRESEPRYILKVEARDQPSKGHQLFSVTDLI-ITLEDVNDNSPQC 925

Query: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723
              +     + E  P G     + ASD D G  G + Y L DG     A   FR+D   G 
Sbjct: 926  ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-----AHGTFRVDLMTGA 980

Query: 724  ICVSQDIDRERDPATYDLLVEAKDGGGLSAQ---AFVRVDLEDVNDN--HPVFNPSTYVT 778
            + + +++D ER  A Y+L + A DGG   A+     V V + DVN+N   P F    +  
Sbjct: 981  LILERELDFER-RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG 1039

Query: 779  SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
             + + +  GT++I V A D DSG+ G + Y L  G   + F+I+  TG+I    PL    
Sbjct: 1040 QVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREF 1099

Query: 839  STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT- 897
            ++   L V A D G +      +V I +      P +  +  +    Y  + ED+P+GT 
Sbjct: 1100 ASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVF----YPSIQEDAPVGTS 1155

Query: 898  ---VKAREPLNSSE-PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 953
               + A +P +SS+  + + I+SG+  G F IHP  G + T + LD E +   +L V   
Sbjct: 1156 VLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215

Query: 954  LGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT--ALYLARAEDRDSGR 1010
                P+  ST  V + ++DVNDN P F      +R+ +   P +   +Y   A D D G 
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGL 1275

Query: 1011 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 1070
            NG + YSI       F+ID   GV+  + +  AGE     LT++A D G  P +A + L 
Sbjct: 1276 NGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATDSGQPPLSASVRLH 1333

Query: 1071 V--VIEKREHSPSWTFEHLVYQVEVSES--LSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
            +  +   R  S    F+   Y   V E+  ++ M  ++  +  P           +++  
Sbjct: 1334 IEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRP-------GLFWFNISG 1386

Query: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 1186
                  F I   TG I + R  D      YN  V      DG     +   I  + + N 
Sbjct: 1387 GDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEV---TDGSRTIATQVHIFMIANINH 1443

Query: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL-----LSDGKFFKMNP 1241
            + P FL     ++V +  VP   + ++ AID D GK+  L+Y +           F+++P
Sbjct: 1444 HRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDP 1501

Query: 1242 NTGELINWVALD-REHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
            ++G L+    LD       H +TV+V D+  P +   + V + V D N + P F Q    
Sbjct: 1502 SSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYE 1561

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
              +   +  G      +  V A D D G NAEV YS+
Sbjct: 1562 ASVPDTIAPGTE----LLQVRAMDADRGVNAEVHYSL 1594



 Score =  317 bits (813), Expect = 4e-86
 Identities = 339/1284 (26%), Positives = 528/1284 (41%), Gaps = 126/1284 (9%)

Query: 70   TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
            T S+ EGLP  T V  + A    + +     + + ED  D      F ++  TG + T +
Sbjct: 2278 TTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKF--FQINGSTGEMSTVQ 2335

Query: 130  RLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
             LD E + H+      +      L     V + V+D+ND+ P F     + +VSEL+  G
Sbjct: 2336 ELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395

Query: 184  TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
                   A DPD+   S   Y ++                     G         SSS +
Sbjct: 2396 HLVLKVQAIDPDSRDTSRLEYLILS--------------------GNQDRHFFINSSSGI 2435

Query: 244  EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
              +  +  + LD    +++ L++ A DG        + V +   + N   P F+Q  Y A
Sbjct: 2436 ISMFNLCKKHLD----SSYNLRVGASDGVF---RATVPVYINTTNANKYSPEFQQHLYEA 2488

Query: 304  AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
             + E+A  G +V  + A D+D GP G + Y++  +              +  F++   +G
Sbjct: 2489 ELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLA------------SEKFSINP-NG 2535

Query: 364  VVRVWRPLDREAQAWHQLVVE--ARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
             +   + LDRE      + ++  ARDGG    VA   V I + D NDN P       T  
Sbjct: 2536 QIATLQKLDRENSTERVIAIKVMARDGGGR--VAFCTVKIILTDENDNPPQFKASEYTVS 2593

Query: 422  GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
              + VS+ +     V +V   DAD                  D + S++ E    D   +
Sbjct: 2594 IQSNVSKDSP----VIQVLAYDADEGQN-------------ADVTYSVNPEDLVKDVIEI 2636

Query: 482  PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                P    + V+  L        +  + A D G P  ++   + L+V       P FS+
Sbjct: 2637 N---PVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693

Query: 542  QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
              Y  S  E    G+ +  V A  A +       + Y++V+ + P             + 
Sbjct: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQDP------VIYSLVRGTTP------------ESN 2735

Query: 602  CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                F++D ++G I   + +D E  +  ++ V+A  L    + +   V+I V DVNDN P
Sbjct: 2736 KDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRP 2795

Query: 662  IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHD 721
            +F    Y A + E+ PVG   +QVTA D D+G  G + Y L          + F ID   
Sbjct: 2796 VFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSES 2854

Query: 722  GQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVT 778
            G I   Q++D E    TY   V A D G    LS+QA V+V + D NDN P F    Y  
Sbjct: 2855 GWITTLQELDCETCQ-TYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913

Query: 779  SISDETQPGTEIINVLATDQD-SGIYGTVAYELIPGNVSSLFTIDSTTGI--IYLTLPLS 835
            S+ + ++PG  +  +   D D S     V   +  G+    F I        I     L 
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973

Query: 836  HLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAP--AEFERPKYTFLVYEDVPEDS 893
               +    L V+A DG        A VT+ IF   +     +  +  YT  V+EDV    
Sbjct: 2974 REHTAKYLLRVTASDGK-----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028

Query: 894  PIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA 952
             I  V A +   +++  I Y +  G    +F + P  G + T   LD E + V  L  +A
Sbjct: 3029 FILKVSATDLDTDTNAQITYSLH-GPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKA 3087

Query: 953  QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012
              G   +C + ++ + V DVNDN P F  +   + +   T   T + +  A D D G N 
Sbjct: 3088 TDGGGRSCQA-DITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANA 3146

Query: 1013 LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLVLTV 1071
             + YS+     G F+ID   GV+ L   L    Q  L LT+RA D G   P + L  +TV
Sbjct: 3147 QVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTV 3206

Query: 1072 -VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ--TQAHPLGPQRAASPLRYSLEPSV 1128
             V+   ++ P   F +  + V+V E   P T++LQ  T   P      A    Y +    
Sbjct: 3207 SVVGLEDYLP--VFLNTEHSVQVPEDAPPGTEVLQLATLTRP-----GAEKTGYRVVSGN 3259

Query: 1129 DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
            +   F +   TG +Y+    D+E++  Y   +         L +V TTV+V + D N++ 
Sbjct: 3260 EQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV-TTVMVNITDVNEHR 3318

Query: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGEL 1246
            P F  D    +V E+ +   VI  ++A D D   N  + Y L+   +   F ++P  GEL
Sbjct: 3319 PQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGEL 3378

Query: 1247 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 1306
                ALDRE    + + +  TD G PP +    + + V D+NDN P F Q          
Sbjct: 3379 QVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQL----NYSTT 3434

Query: 1307 VLEGQPVNMLVTTVFAKDPDEGNN 1330
            V E  P+   V  +   DPD   N
Sbjct: 3435 VQENSPIGSKVLQLILSDPDSPEN 3458



 Score =  313 bits (801), Expect = 9e-85
 Identities = 335/1196 (28%), Positives = 512/1196 (42%), Gaps = 130/1196 (10%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRF 167
            + F ++P+ G I T ++LDRE           +        A   V+I + D ND+ P+F
Sbjct: 2527 EKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQF 2585

Query: 168  PLD----SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQL 223
                   S+Q +VS+ SP        +A+D D G  +   Y+ V P DL KD      ++
Sbjct: 2586 KASEYTVSIQSNVSKDSPVIQV----LAYDADEGQNADVTYS-VNPEDLVKD----VIEI 2636

Query: 224  RYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE 283
               T        L G  +  + LD                  I+A DGG P    L+ V 
Sbjct: 2637 NPVTGVVKVKDSLVGLEN--QTLDFF----------------IKAQDGGPPHWNSLVPVR 2678

Query: 284  LRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGA 343
            L+V+ +  + P F +  Y  +  ED   G+E+  V+A    +     V YS+     P +
Sbjct: 2679 LQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA----VAAQDPVIYSLVRGTTPES 2734

Query: 344  GSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAV 403
               G        F+++  +GV++V +P+D E+   +Q+ V A        V+ V V+I V
Sbjct: 2735 NKDG-------VFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQV 2787

Query: 404  LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
             DVNDNRP    +F  +   A ++E    G  V +V+  D D         TG       
Sbjct: 2788 GDVNDNRP----VFEADPYKAVLTENMPVGTSVIQVTAIDKD---------TGR------ 2828

Query: 464  DGSIS--LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP-PLS 520
            DG +S  LS + G     L        +   ++  LD E+   Y   +VA D G    LS
Sbjct: 2829 DGQVSYRLSADPGSNVHELFAIDSESGWITTLQ-ELDCETCQTYHFHVVAYDHGQTIQLS 2887

Query: 521  TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
            ++  + + + D ND  P F+ + Y+ SV E + PG +V  +   DAD +  +    R   
Sbjct: 2888 SQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQN----RQVT 2943

Query: 581  VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGE 640
              ++    LG      V             +   IS+ +TLDRE      L+V A D   
Sbjct: 2944 CYITEGDPLGQFGISQV------------GDEWRISSRKTLDREHTAKYLLRVTASD--- 2988

Query: 641  PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
                A+  V I V DVNDN P   + +Y   + E    GH  L+V+A+D D+     I Y
Sbjct: 2989 GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITY 3048

Query: 701  SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVD 760
            SL+           F++DPH G++     +DRER    ++L+ +A DGGG S QA + + 
Sbjct: 3049 SLHG-----PGAHEFKLDPHTGELTTLTALDRERKDV-FNLVAKATDGGGRSCQADITLH 3102

Query: 761  LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 820
            +EDVNDN P F PS    ++ D T   T +  V A D D G    V Y L P +    F+
Sbjct: 3103 VEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFS 3161

Query: 821  IDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT-TLAPAEFERP 879
            ID+TTG+I L  PL       L L V A D G         + +    T T++    E  
Sbjct: 3162 IDATTGVIRLEKPLQVRPQAPLELTVRASDLG-------TPIPLSTLGTVTVSVVGLEDY 3214

Query: 880  KYTFLVYE---DVPEDSPIGTVK---AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933
               FL  E    VPED+P GT     A      +E   YR+ SG+  G+F +  R G + 
Sbjct: 3215 LPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILY 3274

Query: 934  TRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
                LD ET P   L+++    S+ + S  T V + + DVN++ P F +     R+ +  
Sbjct: 3275 VNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENA 3334

Query: 993  PPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051
              G  +    A D D   N  I YS I   Q G F I    G L +  +L   +    +L
Sbjct: 3335 LVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSL 3394

Query: 1052 TLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL 1111
             LRA D G  P      + + +     +P   F+ L Y   V E+    +++LQ      
Sbjct: 3395 KLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQ-LNYSTTVQENSPIGSKVLQLILSDP 3453

Query: 1112 GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
                   P  + +    + + F + P  GW+         + + Y  ++ A    D  + 
Sbjct: 3454 DSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQA---SDSGIP 3509

Query: 1172 NVS--TTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 1229
             +S  T+V V V +++  +P+ L   +F+ V E     G++GKI A D D      L Y 
Sbjct: 3510 PLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYS 3567

Query: 1230 LLSD---GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
            L  +   G+ F +    G++I   A     RGH+   V V+D G+    A + VYV
Sbjct: 3568 LAEEETLGRHFSVGAPDGKII---AAQGLPRGHYSFNVTVSD-GTFTTTAGVHVYV 3619



 Score =  295 bits (754), Expect = 3e-79
 Identities = 346/1274 (27%), Positives = 546/1274 (42%), Gaps = 158/1274 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVA--------ATLLGAVVQVEIRVNDVNDHSPRF 167
            F + P  G +     +D E    + F                  QV I V DVND  PRF
Sbjct: 1813 FKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRF 1872

Query: 168  PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
                 ++ +     PG    +  A D D    S   Y++   +        P        
Sbjct: 1873 SEQIYEVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHP-------- 1920

Query: 228  PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVEL-RV 286
                    + GS S L P  L L R+L           I A DG   + T L+ + L +V
Sbjct: 1921 --------VTGSISVLNPAFLGLSRKLT----------IRASDG-LYQDTALVKISLTQV 1961

Query: 287  LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
            LD++     F+QD Y AAV+E+ Q    +  + A    L  N  + Y +           
Sbjct: 1962 LDKSLQ---FDQDVYWAAVKENLQDRKALVILGAQGNHL--NDTLSYFL----------- 2005

Query: 347  GGALGDAAYFAVEELSGVVRVWR-PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
               L     F + + +GV++      DRE Q  H+L VE RD      VA   V +++ D
Sbjct: 2006 ---LNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIED 2062

Query: 406  VNDNRPAI-HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
            VNDN P   H+ + T      + +G  PGD + +VS +D D            LG    +
Sbjct: 2063 VNDNPPKFKHLPYYT-----IIQDGTEPGDVLFQVSATDED------------LGT---N 2102

Query: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
            G+++         F +     P +  + ++ P D ++ + Y L ++A D G+P L +EE 
Sbjct: 2103 GAVTYEFAEDYTYFRI----DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEE 2158

Query: 525  LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
            +L+ V   N   PLF   +YK  V     P  + ++           +   L Y +V+  
Sbjct: 2159 VLVTVR--NKSNPLFQSPYYKVRV-----PENITLYTPILHTQARSPEGLRLIYNIVE-E 2210

Query: 585  APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
             P  L                F  D ++G ++    LD E +      V A D      S
Sbjct: 2211 EPLML----------------FTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFS 2254

Query: 645  ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD 704
                V + V+DVNDN P F + VY  +I+E  P     +Q+ ASD DSG    + Y + +
Sbjct: 2255 -EATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVE 2313

Query: 705  GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLE 762
                 +  + F+I+   G++   Q++D E     + + V A D G   L+ +  V V++ 
Sbjct: 2314 D--GSDVSKFFQINGSTGEMSTVQELDYEAQ-QHFHVKVRAMDKGDPPLTGETLVVVNVS 2370

Query: 763  DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 822
            D+NDN P F    Y  ++S+    G  ++ V A D DS     + Y ++ GN    F I+
Sbjct: 2371 DINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFIN 2430

Query: 823  STTGIIYL-TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            S++GII +  L   HL+S + +L V A DG     V  A V ++I  T    A    P++
Sbjct: 2431 SSSGIISMFNLCKKHLDS-SYNLRVGASDG-----VFRATVPVYINTTN---ANKYSPEF 2481

Query: 882  TFLVYE-DVPEDSPIGTVKAREPL---NSSEP---IFYRISSGDLGGKFSIHPRLGTIRT 934
               +YE ++ E++ +GT K  + L     S P   I Y I +     KFSI+P  G I T
Sbjct: 2482 QQHLYEAELAENAMVGT-KVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPN-GQIAT 2539

Query: 935  RKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
             + LD E  T+ V+ + V A+ G       T V I + D NDN P F  +   + I    
Sbjct: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCT-VKIILTDENDNPPQFKASEYTVSIQSNV 2598

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQ---PGVFAIDRALGVLFLNGSLGAGEQREL 1049
               + +    A D D G+N  + YS+ +P+     V  I+   GV+ +  SL   E + L
Sbjct: 2599 SKDSPVIQVLAYDADEGQNADVTYSV-NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTL 2657

Query: 1050 TLTLRAEDQG-VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
               ++A+D G  H  + + V   V+ K+   P   F   +Y     E L   +++   +A
Sbjct: 2658 DFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPK--FSEPLYTFSAPEDLPEGSEIGIVKA 2715

Query: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
                     S +R +   S    +F + P TG I +R+  D+EST+ Y   V A   ++ 
Sbjct: 2716 VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT 2775

Query: 1169 FLQNVSTTVIVRVWDENDNSPTFLHD-VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227
             + ++  +V ++V D NDN P F  D    +  E  PV   VI ++TAID D+G++GQ+ 
Sbjct: 2776 DVVSL-VSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-QVTAIDKDTGRDGQVS 2833

Query: 1228 YFLLSD-----GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA-VY 1281
            Y L +D      + F ++  +G +     LD E    +   V+  D G   + ++ A V 
Sbjct: 2834 YRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQ 2893

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD-EGNNAEVTYSVSSA 1340
            VS+TD NDN P F      +E    V+E      LV T+   D D    N +VT  ++  
Sbjct: 2894 VSITDENDNAPRF----ASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEG 2949

Query: 1341 RPMPLKGKTAFGKQ 1354
             P+   G +  G +
Sbjct: 2950 DPLGQFGISQVGDE 2963



 Score =  291 bits (744), Expect = 4e-78
 Identities = 323/1242 (26%), Positives = 515/1242 (41%), Gaps = 118/1242 (9%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG---AVVQVEIRVNDVNDHSPRFPLDSL 172
            F ++  +GII       +     Y+       G   A V V I   + N +SP F     
Sbjct: 2427 FFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLY 2486

Query: 173  QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
            + +++E +  GT     +A D D+G + T  YT++      K    P  Q+         
Sbjct: 2487 EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQI--------- 2537

Query: 233  SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIE--AWDGGRPRRTGLLSVELRVLDEN 290
                              L++LDRE +    + I+  A DGG   R    +V++ + DEN
Sbjct: 2538 ----------------ATLQKLDRENSTERVIAIKVMARDGGG--RVAFCTVKIILTDEN 2579

Query: 291  DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
            DNPP F+  EY  +++ +    + V +V A D D G N  V YSV    +          
Sbjct: 2580 DNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLV--------- 2630

Query: 351  GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
                   +  ++GVV+V   L           ++A+DGG     + V V + V+    + 
Sbjct: 2631 --KDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL 2688

Query: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
            P       T      + EG+  G   A  +          +D     L  G    S    
Sbjct: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAA----------QDPVIYSLVRGTTPES---- 2734

Query: 471  LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
                +G F+L     P    + V  P+D ES  LY++ ++A    +  + +  ++ ++V 
Sbjct: 2735 --NKDGVFSL----DPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVG 2788

Query: 531  DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
            D+ND  P+F    YKA ++E    GT V+ V+A D D         R           L 
Sbjct: 2789 DVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYR-----------LS 2837

Query: 591  SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLV 649
            +     VH       FAIDSESG I+T++ LD E  +     VVA D G+   LS+  LV
Sbjct: 2838 ADPGSNVHEL-----FAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALV 2892

Query: 650  SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD-SGLYGFIEYSLYDGFLS 708
             +++ D NDN P F  + Y  ++ E++  G     +   DAD S     +   + +G   
Sbjct: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEG--- 2949

Query: 709  YEAPQAFRIDP--HDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
             +    F I     + +I   + +DRE   A Y L V A DG    A   V + + DVND
Sbjct: 2950 -DPLGQFGISQVGDEWRISSRKTLDREHT-AKYLLRVTASDGK-FQASVTVEIFVLDVND 3006

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
            N P  +   Y   + ++  PG  I+ V ATD D+     + Y L  G  +  F +D  TG
Sbjct: 3007 NSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL-HGPGAHEFKLDPHTG 3065

Query: 827  IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 886
             +     L        +L+  A DGGG +    AD+T+H+         F        V+
Sbjct: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSC--QADITLHVEDVNDNAPRFFPSHCAVAVF 3123

Query: 887  EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
            ++    +P+  V AR+P   +             G FSI    G IR  KPL    Q  +
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183

Query: 947  VLTVQAQLGSAPACSST--EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT-ALYLARA 1003
             LTV+A     P   ST   V ++V+ + D  P FL T   +++ +  PPGT  L LA  
Sbjct: 3184 ELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATL 3243

Query: 1004 EDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP 1062
                + + G   Y + S  + G F +D   G+L++N SL      +  L++    +    
Sbjct: 3244 TRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSS 3300

Query: 1063 QAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GPQRAASPL 1120
             + +  + V + +  EH P   F    Y   V E+      +L   A    GP    S +
Sbjct: 3301 LSDVTTVMVNITDVNEHRPQ--FPQDPYSTRVLENALVGDVILTVSATDEDGPLN--SDI 3356

Query: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 1180
             YSL        F I P  G + + +  D E   +Y+ ++ A       L    T + ++
Sbjct: 3357 TYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHE-DTDIAIQ 3415

Query: 1181 VWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDSGKNGQLLYFLLS---DGKF 1236
            V D NDN P F        V+E SP+   V+  I + D DS +NG    F ++   +G  
Sbjct: 3416 VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILS-DPDSPENGPPYSFRITKGNNGSA 3474

Query: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
            F++ P+ G L+    L R  +  +++ +  +D G PP ++  +V V VT   +   + P 
Sbjct: 3475 FRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVT---EQSHYAPS 3530

Query: 1297 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
             LP  E+ + V E +    +V  + A D D  +   +TYS++
Sbjct: 3531 ALP-LEIFITVGEDEFQGGMVGKIHATDRDPQDT--LTYSLA 3569



 Score =  285 bits (728), Expect = 3e-76
 Identities = 321/1257 (25%), Positives = 505/1257 (40%), Gaps = 198/1257 (15%)

Query: 164  SPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQL 223
            SP+  ++S +     L+ P  A R  +     A +F T+ Y +           G F  L
Sbjct: 47   SPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVV-----------GNFCFL 95

Query: 224  RYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVE 283
            R RT           S++ L          L+RE   ++ L I+A +        L  V 
Sbjct: 96   RIRTKS---------SNTAL----------LNREVRDSYTLIIQATEKTLELEA-LTRVV 135

Query: 284  LRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGA 343
            + +LD+ND  P+F    YR  + ED    + +C+V ATD DLG N    Y+   R     
Sbjct: 136  VHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTR----- 190

Query: 344  GSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAV 403
                     +  FA+   SGVV V   L+   +  H+L V A D   +        S+A 
Sbjct: 191  ---------SEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAA 241

Query: 404  LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
            L                  V  V    R    +A V V+  D +           G    
Sbjct: 242  L------------------VVHVEPALRKPPAIASVVVTPPDSND----------GTTYA 273

Query: 464  DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL-------------LLV 510
               +  +  G E +   + GG PG  F  ++         L  +             L +
Sbjct: 274  TVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL 333

Query: 511  ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
               +GS P    +     +         F +  Y+  +SE + PG+ V+ V  + A    
Sbjct: 334  QARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN- 392

Query: 571  SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVE 630
                 L+Y +   S   N+G               F +++ +G I+T + +D   +   +
Sbjct: 393  -----LQYVLKPSSE--NVG---------------FKLNARTGLITTTKLMDFHDRAHYQ 430

Query: 631  LKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDA 690
            L +        P  A+ +V I + D N++ P+F R  Y+ T+ E+ P G   L VTA+D 
Sbjct: 431  LHIRTS-----PGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDR 485

Query: 691  DSGLYGFIEYSLYDGFLSYEAPQA--FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG 748
            D G  G++ YS+         P+A  F IDP+ G I  S+ +D E     Y   V A D 
Sbjct: 486  DHGENGYVTYSI-------AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDW 538

Query: 749  GG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 805
            G       +  + + L ++NDN P+F       SI  +   G  I+ + A D D      
Sbjct: 539  GSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE--LQN 596

Query: 806  VAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL---ESTTLSLMVSAQDGGGLTAVINADV 862
            + YE++ GN    F ++  +G+I L  P  +L   + T+ SL ++A DG    +    ++
Sbjct: 597  LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNI 656

Query: 863  TI----HI--------------FQTT------LAPAEFERPKYTFL-------------- 884
            T+    H               F  T      L   E    ++T L              
Sbjct: 657  TVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFED 716

Query: 885  -------VYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK 936
                   V E VP ++P+  + A +P    +  + Y I+ G+  G F I    G +    
Sbjct: 717  HFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAA 776

Query: 937  PLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG 995
            PLD+E     +L V    LG+    S   + + V D NDN P F     ++ IS+ T  G
Sbjct: 777  PLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVG 836

Query: 996  TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 1055
            T +     +D DS  NG +RY++ SP    F++    G L + G L    +    L + A
Sbjct: 837  TTIAELTTKDADSEDNGRVRYTLLSPTEK-FSLHPLTGELVVTGHLDRESEPRYILKVEA 895

Query: 1056 EDQGVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLSPMTQM--LQTQAHP 1110
             DQ         V  ++I   +  ++SP    EH   +++V E L P T +  L      
Sbjct: 896  RDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH--NRLKVPEDLPPGTVLTFLDASDPD 953

Query: 1111 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 1170
            LGP   A  +RY L        F +   TG + L R+ D+E    YN  ++A        
Sbjct: 954  LGP---AGEVRYVLMDGAHGT-FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLA 1009

Query: 1171 QNVSTTVIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY 1228
            +     V V V D N+N   P F   V   +V+E+      +  + A D DSG +G+L Y
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY 1069

Query: 1229 FLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
            FL +      F +N +TG +     LDRE   ++ +TVL  DRGS P ++   VY+ VTD
Sbjct: 1070 FLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTD 1129

Query: 1287 INDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
             NDN P   Q +     +  + E  PV   V  + A DPD  +  ++T++++S   M
Sbjct: 1130 ANDNPPQMSQAV----FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYM 1182



 Score =  262 bits (669), Expect = 2e-69
 Identities = 271/972 (27%), Positives = 409/972 (42%), Gaps = 115/972 (11%)

Query: 70   TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
            T S  E LP  + +G ++A    A Q       +   + +S     F + PDTG+I+  +
Sbjct: 2697 TFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRK 2753

Query: 130  RLDRERRDHYSF------VAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
             +D E    Y        +  T + ++V V I+V DVND+ P F  D  +  ++E  P G
Sbjct: 2754 PMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVG 2813

Query: 184  TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
            T+     A D D G      Y L        DP     +L                +   
Sbjct: 2814 TSVIQVTAIDKDTGRDGQVSYRL------SADPGSNVHEL---------------FAIDS 2852

Query: 244  EPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNPPVFEQDEYR 302
            E   +  L+ LD E    +   + A+D G+  + +    V++ + DENDN P F  +EYR
Sbjct: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR 2912

Query: 303  AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             +V E+++PG  V  ++  D D+        S + RQV    + G  LG    F + ++ 
Sbjct: 2913 GSVVENSEPGELVATLKTLDADI--------SEQNRQVTCYITEGDPLGQ---FGISQVG 2961

Query: 363  GVVRVW--RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
               R+   + LDRE  A + L V A DG  +   A+V V I VLDVNDN P    L  T 
Sbjct: 2962 DEWRISSRKTLDREHTAKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYT- 3017

Query: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG-GEGDFA 479
                +V E   PG ++ +VS +D D D   +               I+ SL G G  +F 
Sbjct: 3018 ---GKVHEDVFPGHFILKVSATDLDTDTNAQ---------------ITYSLHGPGAHEFK 3059

Query: 480  LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
            L     P    L     LDRE +D++ L+  ATD G    S +  + L V D+ND  P F
Sbjct: 3060 L----DPHTGELTTLTALDRERKDVFNLVAKATDGGGR--SCQADITLHVEDVNDNAPRF 3113

Query: 540  SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
               H   +V +     T V  V A D D+  +         V  S P            +
Sbjct: 3114 FPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQ-------VVYSLP-----------DS 3155

Query: 600  AECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVND 658
            AE    F+ID+ +G I   + L    Q  +EL V A DLG P PLS    V+++V  + D
Sbjct: 3156 AE--GHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLED 3213

Query: 659  NEPIFWRQVYNATIAEHAPVGHCFLQV---TASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
              P+F    ++  + E AP G   LQ+   T   A+   Y  +         S      F
Sbjct: 3214 YLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVV---------SGNEQGRF 3264

Query: 716  RIDPHDGQICVSQDIDRERDPATYDLLVEA--KDGGGLSAQAFVRVDLEDVNDNHPVFNP 773
            R+D   G + V+  +D E  P  Y L +E   K    LS    V V++ DVN++ P F  
Sbjct: 3265 RLDARTGILYVNASLDFETSPK-YFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQ 3323

Query: 774  STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
              Y T + +    G  I+ V ATD+D  +   + Y LI GN    FTI    G + +   
Sbjct: 3324 DPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA 3383

Query: 834  LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 893
            L   ++++ SL + A D G      + D+ I +      P  F +  Y+  V E+ P  S
Sbjct: 3384 LDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGS 3443

Query: 894  PIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
             +  +   +P    +  P  +RI+ G+ G  F + P  G + T + L    Q    L +Q
Sbjct: 3444 KVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQ 3502

Query: 952  A-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
            A   G  P  S T V + V + +   P+ L     I + +    G  +    A DRD   
Sbjct: 3503 ASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP-- 3560

Query: 1011 NGLIRYSIASPQ 1022
               + YS+A  +
Sbjct: 3561 QDTLTYSLAEEE 3572



 Score =  242 bits (617), Expect = 2e-63
 Identities = 331/1273 (26%), Positives = 507/1273 (39%), Gaps = 125/1273 (9%)

Query: 122  TGIIRTARRLDRERRDHYSFVAA---TLLGAVVQ--VEIRVNDVNDHSPRFPLDSLQLDV 176
            TG++     LD E +  + F      T LG+  +  VE+ V DVND+ P F        +
Sbjct: 2222 TGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281

Query: 177  SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQP-SDLPKDPAGPFFQLRYRTPGPLPSPL 235
            SE  P  T     +A D D+G      Y +V+  SD+ K     FFQ+   T        
Sbjct: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK-----FFQINGST-------- 2328

Query: 236  LPGSSSPLEPLDLVLLRRLDREEAAAH-RLQIEAWDGGRPRRTGLLSVELRVLDENDNPP 294
              G  S ++ LD          EA  H  +++ A D G P  TG   V + V D NDNPP
Sbjct: 2329 --GEMSTVQELDY---------EAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPP 2377

Query: 295  VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA 354
             F Q +Y A V E A  G  V +V+A D D      + Y + +                 
Sbjct: 2378 EFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSG------------NQDR 2425

Query: 355  YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
            +F +   SG++ ++    +   + + L V A DG      ATV V I   + N   P   
Sbjct: 2426 HFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANKYSPE-- 2480

Query: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
              F      A ++E A  G  V  +   D D               G  D +I   L   
Sbjct: 2481 --FQQHLYEAELAENAMVGTKVIDLLAIDKDSG-----------PYGTIDYTIINKLASE 2527

Query: 475  EGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
            +  F++ P G      +     LDRE  +  +  + ++A D G        T+ + + D 
Sbjct: 2528 K--FSINPNGQ-----IATLQKLDRENSTERVIAIKVMARDGGGRVAFC--TVKIILTDE 2578

Query: 533  NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
            ND PP F    Y  S+    +  + V+ V A DADE    +A + Y+V       N   L
Sbjct: 2579 NDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADE--GQNADVTYSV-------NPEDL 2629

Query: 593  QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT 652
               ++          I+  +G +    +L     + ++  + AQD G P  ++   V + 
Sbjct: 2630 VKDVIE---------INPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQ 2680

Query: 653  VDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFL-SYEA 711
            V     + P F   +Y  +  E  P G     V A  A       + YSL  G       
Sbjct: 2681 VVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP----VIYSLVRGTTPESNK 2736

Query: 712  PQAFRIDPHDGQICVSQDIDRERDPA-TYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPV 770
               F +DP  G I V + +D E       D++        + +   V + + DVNDN PV
Sbjct: 2737 DGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPV 2796

Query: 771  FNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI--PG-NVSSLFTIDSTTGI 827
            F    Y   +++    GT +I V A D+D+G  G V+Y L   PG NV  LF IDS +G 
Sbjct: 2797 FEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGW 2856

Query: 828  IYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN-ADVTIHIFQTTLAPAEFERPKYTFLVY 886
            I     L      T    V A D G    + + A V + I         F   +Y   V 
Sbjct: 2857 ITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVV 2916

Query: 887  EDVPEDSPIGTVKAREP--LNSSEPIFYRISSGDLGGKFSIHPRLG---TIRTRKPLDHE 941
            E+      + T+K  +      +  +   I+ GD  G+F I  ++G    I +RK LD E
Sbjct: 2917 ENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDRE 2975

Query: 942  TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
                 +L V A  G   A  S  V I V+DVNDN P   +     ++ +   PG  +   
Sbjct: 2976 HTAKYLLRVTASDGKFQA--SVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKV 3033

Query: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
             A D D+  N  I YS+  P    F +D   G L    +L    +    L  +A D G  
Sbjct: 3034 SATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGR 3093

Query: 1062 PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 1121
               A + L V  +  +++P +   H    V V ++ +  T +    A     Q A + + 
Sbjct: 3094 SCQADITLHVE-DVNDNAPRFFPSHCA--VAVFDNTTVKTPVAVVFARD-PDQGANAQVV 3149

Query: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV 1181
            YSL  S +   F I   TG I L +             V A         +   TV V V
Sbjct: 3150 YSLPDSAE-GHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208

Query: 1182 WDENDNSPTFLHDVLFLKV-EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMN 1240
                D  P FL+    ++V E++P    V+   T     + K G  +      G+ F+++
Sbjct: 3209 VGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGR-FRLD 3267

Query: 1241 PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
              TG L    +LD E    + +++  + + S   +    V V++TD+N++RP FPQ    
Sbjct: 3268 ARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQ---- 3323

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM------PLKGKTAFGKQ 1354
                 +VLE   V  ++ TV A D D   N+++TYS+     +      P KG+    K 
Sbjct: 3324 DPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA 3383

Query: 1355 SCKKQTNKQTNKI 1367
              ++Q +  + K+
Sbjct: 3384 LDREQASSYSLKL 3396



 Score =  231 bits (588), Expect = 5e-60
 Identities = 232/886 (26%), Positives = 365/886 (41%), Gaps = 99/886 (11%)

Query: 518  PLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLR 577
            P      +++ + D N+  PLF++  Y  ++ E   PGT V+ V+A+D D     H    
Sbjct: 437  PGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD-----HGENG 491

Query: 578  YTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQ 636
            Y    ++ P  L                F+ID   G IST + +D E+ + +   +V A 
Sbjct: 492  YVTYSIAGPKAL---------------PFSIDPYLGIISTSKPMDYELMKRIYTFRVRAS 536

Query: 637  DLGEP-PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLY 695
            D G P        + + + ++NDN+P+F       +I +  PVG   + ++A D D    
Sbjct: 537  DWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDE--L 594

Query: 696  GFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR--ERDPATYDLLVEAKDGGGLSA 753
              ++Y +  G       + F ++   G I + +         P +Y L + A DG   ++
Sbjct: 595  QNLKYEIVSG----NELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYAS 650

Query: 754  QAFVRVDLEDVNDNH---PVFNPSTYV------------------------TSISD---- 782
               + + +  V D H   PV    T V                        TS+S     
Sbjct: 651  PTTLNITV--VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQIN 708

Query: 783  -----------------ETQP-GTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
                             E+ P  T +  + ATD D+G  G + Y +  GN    F I+  
Sbjct: 709  HYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELE 768

Query: 825  TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
            TG++ +  PL +  +    L V+  D G         +T+++         F    Y   
Sbjct: 769  TGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLT 828

Query: 885  VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
            + ED    + I  +  ++  +S +    R +      KFS+HP  G +     LD E++P
Sbjct: 829  ISEDTEVGTTIAELTTKDA-DSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEP 887

Query: 945  VVVLTVQAQLGSAPA---CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
              +L V+A+   +      S T++ IT+ DVNDN P  +   + +++ +  PPGT L   
Sbjct: 888  RYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFL 947

Query: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-- 1059
             A D D G  G +RY +     G F +D   G L L   L    +    L+L A D G  
Sbjct: 948  DASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRP 1007

Query: 1060 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
            +  +    V  +V++  E+     F   V+Q +V E+    TQ++   A           
Sbjct: 1008 LARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGE 1066

Query: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
            L+Y L      A F I   TG I      D E    Y   V A       L +V T V +
Sbjct: 1067 LQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV-TEVYI 1125

Query: 1180 RVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--F 1236
             V D NDN P     V +  ++E +PV   V+ ++ A D DS   G+L + + S     F
Sbjct: 1126 EVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-QLDAWDPDSSSKGKLTFNITSGNYMGF 1184

Query: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
            F ++P TG L     LDRE++  H + V V D G P   +T  V V + D+NDN P F  
Sbjct: 1185 FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244

Query: 1297 CLPGKELHVKV--LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
             L    L  ++  +   PV  LV    A D DEG N  VTYS+  +
Sbjct: 1245 KLFNVRLPERLSPVSPGPVYRLV----ASDLDEGLNGRVTYSIEDS 1286



 Score =  177 bits (448), Expect = 8e-44
 Identities = 215/758 (28%), Positives = 313/758 (41%), Gaps = 118/758 (15%)

Query: 125  IRTARRLDRERRDHYSFVAATLLG---AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
            I + + LDRE    Y        G   A V VEI V DVND+SP+          S+L  
Sbjct: 2966 ISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQ---------CSQLLY 3016

Query: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
             G      V  D   G F  +    V  +DL  D      Q+ Y   GP           
Sbjct: 3017 TGK-----VHEDVFPGHFILK----VSATDLDTDTNA---QITYSLHGP------GAHEF 3058

Query: 242  PLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQD 299
             L+P   +L  L  LDRE      L  +A DGG   R+    + L V D NDN P F   
Sbjct: 3059 KLDPHTGELTTLTALDRERKDVFNLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPS 3116

Query: 300  EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
                AV ++      V  V A D D G N  V YS+     P +  G        +F+++
Sbjct: 3117 HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-----PDSAEG--------HFSID 3163

Query: 360  ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDNRPAIHVLFL 418
              +GV+R+ +PL    QA  +L V A D G    ++T+  V+++V+ + D  P    +FL
Sbjct: 3164 ATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLP----VFL 3219

Query: 419  TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV-GLGDGSISLSLEGGEGD 477
                  +V E A PG  V +++     G      E TG   V G   G   L    G   
Sbjct: 3220 NTEHSVQVPEDAPPGTEVLQLATLTRPGA-----EKTGYRVVSGNEQGRFRLDARTG--- 3271

Query: 478  FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                         L V   LD E+   Y L +  +   S  LS   T+++ + D+N+  P
Sbjct: 3272 ------------ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRP 3319

Query: 538  LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
             F Q  Y   V E A  G V++ VSA+D D                      G L S + 
Sbjct: 3320 QFPQDPYSTRVLENALVGDVILTVSATDED----------------------GPLNSDIT 3357

Query: 598  HTAECGPS---FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
            ++   G     F I  + G +   + LDRE   +  LK+ A D G+PPL     ++I V 
Sbjct: 3358 YSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVA 3417

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
            DVNDN P F++  Y+ T+ E++P+G   LQ+  SD DS   G   YS            A
Sbjct: 3418 DVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENG-PPYSF--RITKGNNGSA 3474

Query: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772
            FR+ P DG +  ++ + R R    Y L ++A D G   LS+   VRV + + +   P   
Sbjct: 3475 FRVTP-DGWLVTAEGLSR-RAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSAL 3532

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGIIYLT 831
            P     ++ ++   G  +  + ATD+D     T+ Y L     +   F++ +  G I   
Sbjct: 3533 PLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRHFSVGAPDGKIIAA 3590

Query: 832  --LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
              LP  H      S  V+  DG   T    A V ++++
Sbjct: 3591 QGLPRGH-----YSFNVTVSDG---TFTTTAGVHVYVW 3620



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 8/199 (4%)

Query: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPY 1138
            S +W F H  Y   + E+ SP T +   +   +        +RY +     + +F    Y
Sbjct: 28   SSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEY 87

Query: 1139 T--GWIYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 1190
                + +LR +    +T   N      + +     E        T V+V + D+ND  P 
Sbjct: 88   VVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL 147

Query: 1191 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWV 1250
            F      + + E    +  I K+TA D D G+N +  Y   +  + F ++P +G +    
Sbjct: 148  FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAG 207

Query: 1251 ALDREHRGHHEMTVLVTDR 1269
             L+   RG HE+ VL  DR
Sbjct: 208  KLNVTWRGKHELQVLAVDR 226



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 9/135 (6%)

Query: 1232 SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
            S+   FK+N  TG +     +D   R H+++ +  +     P  A+  V + + D N++ 
Sbjct: 401  SENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCNNHA 455

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAF 1351
            P F +      L     E  P    V  V A D D G N  VTYS++  + +P       
Sbjct: 456  PLFNRSSYDGTLD----ENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYL 511

Query: 1352 GKQSCKKQTNKQTNK 1366
            G  S  K  + +  K
Sbjct: 512  GIISTSKPMDYELMK 526



 Score = 31.6 bits (70), Expect = 5.5
 Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 5/72 (6%)

Query: 131 LDRERRDHYSFVAATL-----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
           L+RE RD Y+ +         L A+ +V + + D ND  P F   S ++ +SE  P  + 
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166

Query: 186 FRLPVAHDPDAG 197
                A D D G
Sbjct: 167 ICKVTATDADLG 178


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  360 bits (923), Expect = 7e-99
 Identities = 358/1253 (28%), Positives = 530/1253 (42%), Gaps = 136/1253 (10%)

Query: 125  IRTARRLDRERRDHYSFVAATLLGA-----VVQVEIRVNDVNDHSPRFPLDSLQLDVSEL 179
            IR A  LD E  D Y F               +V+I + + ND+ P F      + + E 
Sbjct: 413  IRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472

Query: 180  SPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSD---LPKDPAGPFFQLRYRTPGPLPSPLL 236
               GT+    +A D DAG F    Y      D   L KD                     
Sbjct: 473  VTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------- 513

Query: 237  PGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
                       ++L+ RLD E      L I A DGG    TG   V + VLD NDN P F
Sbjct: 514  ----------LIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTF 561

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
            ++D Y  A+RE+     ++ R+RATD D  PN  + YS+             A G     
Sbjct: 562  QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---------VSASAFGSYFDI 612

Query: 357  AVEELSGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
            ++ E  GV+ V RPLD E  +     L V A D G  P  +TV V+I V D NDN P   
Sbjct: 613  SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT-- 670

Query: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
              F        V E    G  V  ++ +D D   E             G  SI  SLEG 
Sbjct: 671  --FSKPAYFVSVVENIMAGATVLFLNATDLDRSRE------------YGQESIIYSLEGS 716

Query: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD--AGSPPLSTEETLLLRVADL 532
                     G      +     LDRE++  Y L++ A D   G    +   T+ + + D+
Sbjct: 717  TQFRINARSGE-----ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771

Query: 533  NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
            ND  P +    Y  ++ E   P + V  V A D D   +       T+V    P N    
Sbjct: 772  NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG------TLVYSIQPPN---- 821

Query: 593  QSKMVHTAECGPSFAIDSESGAISTIRT-LDREVQEAVELKVVAQ------DLGEPPLSA 645
                         ++++S +G I T    LDRE  +  E +++ +      D G PPL A
Sbjct: 822  -----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870

Query: 646  TCLVSITVD--DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
            T   ++ V+  D+NDN+P F    + A + E  P G    QV A D D GL G + Y + 
Sbjct: 871  TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930

Query: 704  DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDL 761
             G    +    F I+   G +  + ++DRER  A Y L V A D G    S+ + + + +
Sbjct: 931  VGMPRMD----FLINSSSGVVVTTTELDRER-IAEYQLRVVASDAGTPTKSSTSTLTIHV 985

Query: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTI 821
             DVND  P F P+ Y  S+S++      ++ +  TD D G+   ++Y +  GNV   F++
Sbjct: 986  LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGG--GLTAVINADVTIHIFQTTLAPAEFERP 879
                 ++   + L    +    L++ A D G  G      A V + +         F + 
Sbjct: 1046 GYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQS 1105

Query: 880  KYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTI-RTRKP 937
             Y   V ED+PE   I  +KA +        ++YRI  G+ G  F IH   G + R  +P
Sbjct: 1106 SYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP 1165

Query: 938  LDHETQPVVVLTVQA---QLGSAPACSSTEVNITVMDVNDNHPAFLRTS-DEIRISQTTP 993
            LD E     VL V+A    LG  P  SS  V + V D+ND  P F +     + + +T  
Sbjct: 1166 LDRERNSSHVLIVEAYNHDLG--PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             GT++ + +A DRDSG  GL+ Y I S   G F ID + G++     L    +    + +
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283

Query: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
             A DQ          + + +   E   +  F +  Y+  + E+L+  T++++ QA+ +  
Sbjct: 1284 SATDQAPPFNQGFCSVYITL-LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342

Query: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
                +    +   +   A+F I   TG I ++   D E    Y   V A   +DG  +  
Sbjct: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA---DDGGPKVD 1399

Query: 1174 STT-VIVRVWDENDNSP--TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230
            ST  V + V DENDNSP   F  D      E+ PV Q V   + A D D+G NGQ+++ L
Sbjct: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV-ATVKAWDPDAGSNGQVVFSL 1458

Query: 1231 LSDG-----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 1285
             S       +    N + GE+     LDRE   H+ + V+ +DRG+PPR     + V++ 
Sbjct: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518

Query: 1286 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
            DINDN P           +V V E       V  V A D D G N+ ++Y ++
Sbjct: 1519 DINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568



 Score =  350 bits (897), Expect = 7e-96
 Identities = 365/1279 (28%), Positives = 548/1279 (42%), Gaps = 150/1279 (11%)

Query: 115  DFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSPR 166
            D  ++   G+I  +R LD E+  +       +        L + V V I V D ND+ P 
Sbjct: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670

Query: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAG--------LFSTQGYTLVQPSDLPKDPAG 218
            F   +  + V E    G       A D D          ++S +G T             
Sbjct: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------------ 718

Query: 219  PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG--RPRR 276
              F++  R+                   ++     LDRE  + + L + A DGG    ++
Sbjct: 719  --FRINARSG------------------EITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758

Query: 277  TGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVR 336
            TG+ +V + +LD NDN P ++   Y   + E   P ++V  V A D DLG NG + YS+ 
Sbjct: 759  TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI- 817

Query: 337  ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP-LDR------EAQAWHQLVVEARDGG 389
              Q P             ++++   +G +R     LDR      EA+   ++VV   D G
Sbjct: 818  --QPPN-----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864

Query: 390  AEPEVAT--VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447
              P  AT    V + +LD+NDN P    L      VA V EG   G  + +V   D D  
Sbjct: 865  RPPLKATSSATVFVNLLDLNDNDPTFQNLPF----VAEVLEGIPAGVSIYQVVAIDLD-- 918

Query: 448  WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507
                         GL +G +S  +  G      L     GV     E  LDRE    Y+L
Sbjct: 919  ------------EGL-NGLVSYRMPVGMPRMDFLINSSSGVVVTTTE--LDRERIAEYQL 963

Query: 508  LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
             +VA+DAG+P  S+  TL + V D+ND+ P F    Y  SVSE       V+W++ +D D
Sbjct: 964  RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023

Query: 568  EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
                                 L +  S  +        F++      + T+  LDRE   
Sbjct: 1024 -------------------VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTA 1064

Query: 628  AVELKVVAQDLGE--PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685
            A  L + A D G      + T  V +TV DVNDN PIF +  Y A++ E  P GH  LQ+
Sbjct: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124

Query: 686  TASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLLVE 744
             A+DAD G +G + Y +  G         FRI   +G +    + +DRER+ +++ L+VE
Sbjct: 1125 KATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLIVE 1179

Query: 745  A--KDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYV-TSISDETQPGTEIINVLATDQDSG 801
            A   D G + +   V V +ED+ND  PVF    Y    + +    GT +I V ATD+DSG
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239

Query: 802  IYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD 861
              G V Y ++ G     F ID +TG+I     L +   T+  + VSA D           
Sbjct: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCS 1298

Query: 862  VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR--EPLNSSEPIFYRISSGDL 919
            V I +        +F    Y   + E++   + I  V+A   + LN     F   +S   
Sbjct: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQA 1358

Query: 920  GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 979
               F I    G I  +  +D E      LTV A  G     S+ +V ITV+D NDN P F
Sbjct: 1359 KALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF 1418

Query: 980  LRTSDE-IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAI---DRALGV 1034
              TSD  + I +  P G  +   +A D D+G NG + +S+AS    G F I   + ++G 
Sbjct: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478

Query: 1035 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVS 1094
            +F+   L   E     L + A D+G  P+    +L V I     +P        Y V V+
Sbjct: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVN 1538

Query: 1095 ESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 1152
            E++   T ++Q +A    +G     S L Y +        F +   +G I  R       
Sbjct: 1539 ENVGGGTAVVQVRATDRDIG---INSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRE 1595

Query: 1153 TQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-I 1210
             Q++ + + A + ++G    + +T V V + DENDN+P F      + ++E P      +
Sbjct: 1596 RQSF-YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1654

Query: 1211 GKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDRE-HRGHHEMTVLVT 1267
              I A+D+D G NG + Y +++      F+++ + G +     LD E   G + + V  T
Sbjct: 1655 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTAT 1714

Query: 1268 DRG---SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 1324
            D+    S    +T  V V+V DINDN P FP+   G     +V EGQP    V T  A D
Sbjct: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP---FEVTEGQP-GPRVWTFLAHD 1770

Query: 1325 PDEGNNAEVTYSVSSARPM 1343
             D G N +V YS+    P+
Sbjct: 1771 RDSGPNGQVEYSIMDGDPL 1789



 Score =  349 bits (896), Expect = 9e-96
 Identities = 361/1270 (28%), Positives = 551/1270 (43%), Gaps = 142/1270 (11%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV--------VQVEIRVNDVNDHSPRF 167
            F ++  +G I T   LDRE +  Y  +   + G V          V I + D+ND+ P +
Sbjct: 719  FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW 778

Query: 168  PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
                  +++ E++PP +     VA DPD G   T  Y++         P   F+ L   T
Sbjct: 779  KDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI--------QPPNKFYSLNSTT 830

Query: 228  PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP--RRTGLLSVELR 285
                 +  +    +P +P +  L+R          ++ +   D GRP  + T   +V + 
Sbjct: 831  GKIRTTHAMLDRENP-DPHEAELMR----------KIVVSVTDCGRPPLKATSSATVFVN 879

Query: 286  VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGS 345
            +LD NDN P F+   + A V E    G  + +V A D D G NG V Y +          
Sbjct: 880  LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM------ 933

Query: 346  GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
                      F +   SGVV     LDRE  A +QL V A D G   + +T  ++I VLD
Sbjct: 934  ------PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
            VND  P     F        VSE       V  ++ +D D              VGL + 
Sbjct: 988  VNDETPT----FFPAVYNVSVSEDVPREFRVVWLNCTDND--------------VGL-NA 1028

Query: 466  SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE-- 523
             +S  + GG  D     G    V    V   LDRE+   Y L+L A D G  P+      
Sbjct: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVV--GLDRETTAAYMLILEAIDNG--PVGKRHTG 1084

Query: 524  --TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
              T+ + V D+ND  P+F Q  Y+ASV E    G  ++ + A+DADE      W R    
Sbjct: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR---- 1140

Query: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST-IRTLDREVQEAVELKVVAQDLGE 640
                          ++H    G +F I   +G +    R LDRE   +  L V A +   
Sbjct: 1141 --------------ILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185

Query: 641  PPLSATCLVSITVDDVNDNEPIFWRQVYNAT-IAEHAPVGHCFLQVTASDADSGLYGFIE 699
             P+ ++  V + V+D+ND  P+F +Q Y+   + E A +G   + V A+D DSG  G + 
Sbjct: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245

Query: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRV 759
            Y +  G     A   F ID   G I     +D E    +Y + V A D      Q F  V
Sbjct: 1246 YRILSG-----AEGKFEIDESTGLIITVNYLDYE-TKTSYMMNVSATDQAPPFNQGFCSV 1299

Query: 760  DLEDVN--DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVS 816
             +  +N  D    F+ ++Y  +I +    GTEI+ V A   D+    T  +         
Sbjct: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK 1359

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
            +LF ID+ TG+I +   +   +    +L V A DGG        D T+ ++ T L   + 
Sbjct: 1360 ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP-----KVDSTVKVYITVLDEND- 1413

Query: 877  ERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEPIFYRISSGDLGGKFSI---H 926
              P++ F       +PED P+G    TVKA +P   S+  + + ++SG++ G F I   +
Sbjct: 1414 NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473

Query: 927  PRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRT-SD 984
              +G +   +PLD E     +L V A   G+ P      + +T++D+NDN P        
Sbjct: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGY 1533

Query: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGA 1043
             + +++    GTA+   RA DRD G N ++ Y I      + F +DR  G +    +   
Sbjct: 1534 NVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPD 1593

Query: 1044 GEQREL-TLTLRAEDQGVHPQAALL-VLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM- 1100
             E++    L    ED+G    +A   V   ++++ +++P +   H  Y+V + E    + 
Sbjct: 1594 RERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH--YEVLLDEGPDTLN 1651

Query: 1101 TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYN 1157
            T ++  QA  L  GP      + Y++        F I  + G I   ++ DYE S   Y 
Sbjct: 1652 TSLITIQALDLDEGPN---GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708

Query: 1158 FRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV--LFLKVEESPVPQGVIGKI 1213
              V A    P        +TTV+V V D NDN PTF  D    F   E  P P+  +   
Sbjct: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR--VWTF 1766

Query: 1214 TAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGEL--INWVALDREHRGHHEMTVLVTDR 1269
             A D DSG NGQ+ Y ++       F ++P  G L     V LDRE    + +T+   DR
Sbjct: 1767 LAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826

Query: 1270 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329
            G PP ++TM V + V DINDN P     L    +++ + E  PV+  V  V A D D G 
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDP----VLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882

Query: 1330 NAEVTYSVSS 1339
            NA +T+++++
Sbjct: 1883 NARLTFNITA 1892



 Score =  345 bits (884), Expect = 2e-94
 Identities = 366/1286 (28%), Positives = 556/1286 (43%), Gaps = 163/1286 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLD 170
            F +   TG+I     +DRE+ D Y+       G     + V+V I V D ND+SPRF   
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1421

Query: 171  S-LQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
            S   + + E  P G       A DPDAG      ++L   +      AG F         
Sbjct: 1422 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI-----AGAF--------- 1467

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
                 ++  + S  E   + + R LDREE   + LQ+ A D G P R     +++ +LD 
Sbjct: 1468 ----EIVTTNDSIGE---VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520

Query: 290  NDNPPVFEQD-EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDNPPV E    Y  +V E+   G  V +VRATDRD+G N  + Y +       A     
Sbjct: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----- 1575

Query: 349  ALGDAAYFAVEELSGVVRVW-RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
                   F ++ +SG +     P DRE Q+++ LV    D G     AT  V + ++D N
Sbjct: 1576 -------FRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628

Query: 408  DNRPAI---HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
            DN P     H   L + G   ++        +  +   D D                  +
Sbjct: 1629 DNAPMFQQPHYEVLLDEGPDTLNTS------LITIQALDLDEG---------------PN 1667

Query: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE-SRDLYELLLVATDAG---SPPLS 520
            G+++ ++  G            GV     E  LD E S   Y L++ ATD     S  L+
Sbjct: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCPILSHRLT 1725

Query: 521  TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
            +  T+L+ V D+ND  P F + +          PG  V    A D D   +         
Sbjct: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPN--------- 1776

Query: 581  VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT--LDREVQEAVELKVVAQDL 638
                     G ++  ++     G  F I    G +   +   LDRE      L + A+D 
Sbjct: 1777 ---------GQVEYSIMDGDPLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826

Query: 639  GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFI 698
            G PPLS+T LV I V D+NDN+P+      N TI+E++PV      V ASDADSG    +
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886

Query: 699  EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQA--- 755
             +++  G       +AF I+   G + V++ +DRER P  Y L +  KD       A   
Sbjct: 1887 TFNITAG----NRERAFFINATTGIVTVNRPLDRERIP-EYKLTISVKDNPENPRIARRD 1941

Query: 756  --FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT--EIIN--VLATDQDSGIYGTVAYE 809
               + + L D NDNHP+F  STY   + + +  GT   ++N  +LA D D  IY  V Y+
Sbjct: 1942 YDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001

Query: 810  LIPGNVSSLFTIDSTTGIIY----LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI- 864
            L+ G  S LF I+S+TG++     + +         L L++ A+D G L +  +  +TI 
Sbjct: 2002 LL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL 2060

Query: 865  --HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGG 921
              +  + T +PA       T  + E+ P    +  V A  E    +  + YRI +G    
Sbjct: 2061 DDNDNRPTFSPATL-----TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114

Query: 922  KFSIHPRLGTIRT-RKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAF 979
            +F IH   G IR     +D E Q    LTV A   G+ P   +  V I + D+ND+ P F
Sbjct: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174

Query: 980  LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS------------PQPGVFA 1027
            L     + + ++  PGT +    A D D   N  + Y I               Q   FA
Sbjct: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232

Query: 1028 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLV----LTV-VIEKREHSPS 1081
            ++   G + +   +         +TL   D     P+ ++ V    LTV V++  +++P 
Sbjct: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292

Query: 1082 WTFEHLVYQVE-VSESLSPMTQMLQTQAHPLGPQRAASPL-RYSLEPSVDSAMFGIRPYT 1139
            +    + Y +E + E  +P T ++   A  + P +  + L  Y+L   V      +   +
Sbjct: 2293 FKPFGITYYMERILEGATPGTTLIAVAA--VDPDKGLNGLVTYTLLDLVPPGYVQLEDSS 2350

Query: 1140 -GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS-TTVIVRVWDENDNSPTFLHDVLF 1197
             G +   R  DYE     NF V A   ++G     +   V + + D NDN+P F     +
Sbjct: 2351 AGKVIANRTVDYEEVHWLNFTVRA--SDNGSPPRAAEIPVYLEIVDINDNNPIF-DQPSY 2407

Query: 1198 LKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGELINWVALDRE 1255
             +     VP G +I  +TA D DSG N  L+ + L DG+  F +NP TG++    +LDRE
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSG-NFALIEYSLGDGESKFAINPTTGDIYVLSSLDRE 2466

Query: 1256 HRGHHEMTVLVTDR----GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311
             + H+ +T L  D      S  R  ++ V + V D+ND RP F +     +    V E +
Sbjct: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK----PQFSTSVYENE 2522

Query: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            P    V T+ A D DEG N E+TYS+
Sbjct: 2523 PAGTSVITMMATDQDEGPNGELTYSL 2548



 Score =  334 bits (856), Expect = 4e-91
 Identities = 347/1285 (27%), Positives = 549/1285 (42%), Gaps = 148/1285 (11%)

Query: 114  DDFHVHPDTGII-RTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPR 166
            ++F +H   G++ R  R LDRER   +  +          + + V+V + V D+ND +P 
Sbjct: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207

Query: 167  FPLDSL-QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
            F      +L + E +  GT+  +  A D D+G      Y ++  ++              
Sbjct: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE-------------- 1253

Query: 226  RTPGPLPSPLLPGSSSPLEPLDLVL-LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVEL 284
                        G     E   L++ +  LD E   ++ + + A D   P   G  SV +
Sbjct: 1254 ------------GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301

Query: 285  RVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAG 344
             +L+E D    F    Y AA+ E+   G E+ RV+A   D              Q+    
Sbjct: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID-----------NLNQITYRF 1350

Query: 345  SGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL 404
            +   +    A F ++ ++GV+ V   +DRE   ++ L V A DGG + + +TV+V I VL
Sbjct: 1351 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD-STVKVYITVL 1409

Query: 405  DVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
            D NDN P       T      + E    G  VA V        W+ +  + G++   L  
Sbjct: 1410 DENDNSPRFD---FTSDSAVSIPEDCPVGQRVATVKA------WDPDAGSNGQVVFSLAS 1460

Query: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
            G+I+ + E       +      G  F  V  PLDRE  D Y L +VA+D G+PP   +  
Sbjct: 1461 GNIAGAFE------IVTTNDSIGEVF--VARPLDREELDHYILQVVASDRGTPPRKKDHI 1512

Query: 525  LLLRVADLNDQPPLFSQQH-YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
            L + + D+ND PP+      Y  SV+E    GT V+ V A+D D                
Sbjct: 1513 LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD---------------- 1556

Query: 584  SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPP 642
                 + S+ S  +       +F +D  SG I+T     DRE Q    L    +D G P 
Sbjct: 1557 ---IGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT 1613

Query: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAP-VGHCFLQVTASDADSGLYGFIEYS 701
            LSAT  V +T+ D NDN P+F +  Y   + E    +    + + A D D G  G + Y+
Sbjct: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD-----GGGLSAQAF 756
            +  G +       FRID H G I  ++++D E     Y L+V A D        L++   
Sbjct: 1674 IVAGNIV----NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSIS-DETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815
            V V++ D+NDN P F P  Y       E QPG  +   LA D+DSG  G V Y ++ G+ 
Sbjct: 1730 VLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDP 1788

Query: 816  SSLFTIDSTTGIIYLTLPLSHLESTTLS---LMVSAQDGGGLTAVINADVTIHIFQTTLA 872
               F I    G++ +   +  L+  T++   L + A+D G         V I +      
Sbjct: 1789 LGEFVISPVEGVLRVRKDVE-LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDN 1847

Query: 873  PAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGT 931
                        + E+ P  S +  V A +  +     + + I++G+    F I+   G 
Sbjct: 1848 DPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGI 1907

Query: 932  IRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVM---DVNDNHPAFLRTSDEIR 987
            +   +PLD E  P   LT+  +     P  +  + ++ ++   D NDNHP F +++ +  
Sbjct: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967

Query: 988  ISQTTPPGTALYLAR----AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL-- 1041
            + + +P GT L +      A D D     ++ Y +   Q G+F I+ + GV+ +   +  
Sbjct: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027

Query: 1042 --GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 1099
               A     L L L AED G+    A L++T+ ++  ++ P  TF      V + E+  P
Sbjct: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITI-LDDNDNRP--TFSPATLTVHLLENCPP 2084

Query: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL-RRQFDYESTQTYNF 1158
               +LQ  A           L Y +E       F I   TG I +     D E  ++Y  
Sbjct: 2085 GFSVLQVTATD-EDSGLNGELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRL 2142

Query: 1159 RVFAWIPEDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAI 1216
             V A    D     +S T IV +   D ND+ P FL+ +  + V ES  P  VI  ITAI
Sbjct: 2143 TVVA---TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199

Query: 1217 DMDSGKNGQLLYFLL-------------SDGKFFKMNPNTGELINWVALDREHRGHHEMT 1263
            D D   N +L Y ++             +    F +N NTG ++    ++RE    +E+T
Sbjct: 2200 DHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257

Query: 1264 VLVTDRGS--PPRNATMA---VYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLV 1317
            + V D  S  P R+ ++    + V+V D+NDN P F     G   ++ ++LEG      +
Sbjct: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF--GITYYMERILEGATPGTTL 2315

Query: 1318 TTVFAKDPDEGNNAEVTYSVSSARP 1342
              V A DPD+G N  VTY++    P
Sbjct: 2316 IAVAAVDPDKGLNGLVTYTLLDLVP 2340



 Score =  325 bits (833), Expect = 2e-88
 Identities = 365/1341 (27%), Positives = 550/1341 (41%), Gaps = 174/1341 (12%)

Query: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
            +DEG  PDTL   +   + A    EG    ++       +++ F +    G+I  A+ LD
Sbjct: 1643 LDEG--PDTLNTSLIT-IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699

Query: 133  RE-RRDHYSFVAATL---------LGAVVQVEIRVNDVNDHSPRFPLD-SLQLDVSELSP 181
             E     Y+ +             L +   V + VND+ND+ P FP D     +V+E   
Sbjct: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQ 1758

Query: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            PG      +AHD D+G      Y+++       DP G F                     
Sbjct: 1759 PGPRVWTFLAHDRDSGPNGQVEYSIMDG-----DPLGEFV-------------------- 1793

Query: 242  PLEPLDLVLLRR----LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFE 297
             + P++ VL  R    LDRE  A + L I A D G P  +  + V +RVLD NDN PV  
Sbjct: 1794 -ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852

Query: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357
                   + E++   + V  V A+D D G N  + +++ A     A            F 
Sbjct: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA------------FF 1900

Query: 358  VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL---DVNDNRPAIH 414
            +   +G+V V RPLDRE    ++L +  +D    P +A     + ++   D NDN P   
Sbjct: 1901 INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP--- 1957

Query: 415  VLFLTEGGVARVSEGARPGDYVARVS--VSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
             LF      A V E +  G  +  ++  +   D D +     T +L   LG  S    + 
Sbjct: 1958 -LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL---LGAQSGLFDIN 2013

Query: 473  GGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLRVA 530
               G   +  G             +DRE  S  + ELLL+A D G   L++   LL+ + 
Sbjct: 2014 SSTGVVTVRSGVI-----------IDREAFSPPILELLLLAEDIGL--LNSTAHLLITIL 2060

Query: 531  DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
            D ND  P FS       + E   PG  V+ V+A+D D                       
Sbjct: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG--------------------- 2099

Query: 591  SLQSKMVHTAECGPS--FAIDSESGAISTIR-TLDREVQEAVELKVVAQDLGEPPLSATC 647
             L  ++V+  E G    F I   +G I     T+DRE QE+  L VVA D G  PLS T 
Sbjct: 2100 -LNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158

Query: 648  LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG------LYGFIEYS 701
            +V+I +DD+ND+ P F   +   ++ E A  G     +TA D D        + G +   
Sbjct: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ------- 754
              D  +  +   AF ++ + G + V   ++RE   ATY++ +   D      +       
Sbjct: 2219 DTDRLVPNQE-DAFAVNINTGSVMVKSPMNREL-VATYEVTLSVIDNASDLPERSVSVPN 2276

Query: 755  AFVRVDLEDVNDNHPVFNP---STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 811
            A + V++ DVNDN P F P   + Y+  I +   PGT +I V A D D G+ G V Y L+
Sbjct: 2277 AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL 2336

Query: 812  ----PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
                PG V      DS+ G +     + + E   L+  V A D G         V + I 
Sbjct: 2337 DLVPPGYVQ---LEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393

Query: 868  QTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
                    F++P Y   V+EDVP  + I TV A +  +S        S GD   KF+I+P
Sbjct: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDA-DSGNFALIEYSLGDGESKFAINP 2452

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRT 982
              G I     LD E +   +LT  A+       S     S +V I V+DVND  P F + 
Sbjct: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512

Query: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLG 1042
                 + +  P GT++    A D+D G NG + YS+  P    F +D   G++     L 
Sbjct: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ 2572

Query: 1043 AGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMT 1101
            + E  + +LT+ A D G  P     ++L  VI+  ++ P +        + + E +   +
Sbjct: 2573 SYE--KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630

Query: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
             + +  A     +     +RYS   +    D   F I P +G I   ++ D ES   Y+ 
Sbjct: 2631 NVYEVYATD-KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689

Query: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGK 1212
             + A              + V + D +DN P F+           L V E      ++G 
Sbjct: 2690 ILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGN 2749

Query: 1213 IT-AIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
            +T A+D D G N  + YF+   ++ K F + P+ G L+    LDRE        V  +  
Sbjct: 2750 VTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSN 2808

Query: 1270 GS--PPRNAT-----------MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
             S  PPR  +             V V + DIND  P F +     E    V     V   
Sbjct: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA----EYTAGVATDAKVGSE 2864

Query: 1317 VTTVFAKDPDEGNNAEVTYSV 1337
            +  V A D D GNN+ V YS+
Sbjct: 2865 LIQVLALDADIGNNSLVFYSI 2885



 Score =  323 bits (827), Expect = 9e-88
 Identities = 359/1281 (28%), Positives = 544/1281 (42%), Gaps = 153/1281 (11%)

Query: 116  FHVHPDTGIIRTARR-LDRERRDHYS-------FVAATLLG-------AVVQVEIRVNDV 160
            + ++  TG IRT    LDRE  D +         V+ T  G       +   V + + D+
Sbjct: 824  YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDL 883

Query: 161  NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPF 220
            ND+ P F       +V E  P G +    VA D D GL     Y +  P  +P+      
Sbjct: 884  NDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMPR------ 935

Query: 221  FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLL 280
                           L  SSS +    +V    LDRE  A ++L++ A D G P ++   
Sbjct: 936  ------------MDFLINSSSGV----VVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979

Query: 281  SVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340
            ++ + VLD ND  P F    Y  +V ED      V  +  TD D+G N  + Y +    V
Sbjct: 980  TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039

Query: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVR 398
             G             F+V     VVR    LDRE  A + L++EA D G   +    T  
Sbjct: 1040 DGK------------FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087

Query: 399  VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458
            V + VLDVNDNRP    +FL     A V E    G  + ++  +DAD          GE 
Sbjct: 1088 VFVTVLDVNDNRP----IFLQSSYEASVPEDIPEGHSILQLKATDAD---------EGEF 1134

Query: 459  G-----VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
            G     +  G+   +  +    G   LL  GP          PLDRE    + L++ A +
Sbjct: 1135 GRVWYRILHGNHGNNFRIHVSNG---LLMRGP---------RPLDRERNSSHVLIVEAYN 1182

Query: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHY-KASVSEAAAPGTVVMWVSASDADEAGSD 572
                P+ +   +++ V D+ND+ P+F+QQ Y +  + E A  GT V+ V A+D D    D
Sbjct: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD--SGD 1240

Query: 573  HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632
               + Y +        L   + K          F ID  +G I T+  LD E + +  + 
Sbjct: 1241 GGLVNYRI--------LSGAEGK----------FEIDESTGLIITVNYLDYETKTSYMMN 1282

Query: 633  VVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS 692
            V A D   P     C V IT+ +  D    F    Y A I E+  +G   ++V A   D+
Sbjct: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342

Query: 693  GLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-GL 751
                 I Y  ++ + S +A   F+ID   G I V   +DRE+    Y L V A DGG  +
Sbjct: 1343 --LNQITYR-FNAYTSTQAKALFKIDAITGVITVQGLVDREKGD-FYTLTVVADDGGPKV 1398

Query: 752  SAQAFVRVDLEDVNDNHPVFN-PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 810
             +   V + + D NDN P F+  S    SI ++   G  +  V A D D+G  G V + L
Sbjct: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSL 1458

Query: 811  IPGNVSSLFTIDSTT---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
              GN++  F I +T    G +++  PL   E     L V A D G  T     D   HI 
Sbjct: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRG--TPPRKKD---HIL 1513

Query: 868  QTTLA-----PAEFERP-KYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG 920
            Q T+      P   E P  Y   V E+V   + +  V+A +  +  +  + Y I+ G+  
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573

Query: 921  GKFSIHPRLGTIRTR-KPLDHETQPV--VVLTVQAQLGSAPACSSTEVNITVMDVNDNHP 977
              F +    G I TR  P D E Q    +V TV+ + G+    ++T V +T++D NDN P
Sbjct: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE-GTPTLSATTHVYVTIVDENDNAP 1632

Query: 978  AFLRTSDEIRISQTTPP-GTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVL 1035
             F +   E+ + +      T+L   +A D D G NG + Y+I A      F IDR +GV+
Sbjct: 1633 MFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVI 1692

Query: 1036 FLNGSLGAG-EQRELTLTLRAEDQ----GVHPQAALLVLTVVIEKREHSPSWTFEHLVYQ 1090
                 L         TL + A DQ         +   VL  V +  ++ P++  ++    
Sbjct: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY-EGP 1751

Query: 1091 VEVSESL-SPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR--Q 1147
             EV+E    P            GP      + YS+        F I P  G + +R+  +
Sbjct: 1752 FEVTEGQPGPRVWTFLAHDRDSGPN---GQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE 1808

Query: 1148 FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV--RVWDENDNSPTFLHDVLFLKVEESPV 1205
             D E+   YN  + A    D  +  +S+T++V  RV D NDN P  L+  + + + E+  
Sbjct: 1809 LDRETIAFYNLTICA---RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865

Query: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMT 1263
                +  + A D DSG N +L + + +    + F +N  TG +     LDRE    +++T
Sbjct: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLT 1925

Query: 1264 VLVTDRGSPPRNATM---AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
            + V D    PR A      + + ++D NDN P F +     E+      G P+ +L   +
Sbjct: 1926 ISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPI 1985

Query: 1321 FAKDPDEGNNAEVTYSVSSAR 1341
             A D D+   A VTY +  A+
Sbjct: 1986 LALDADQDIYAVVTYQLLGAQ 2006



 Score =  318 bits (815), Expect = 2e-86
 Identities = 356/1318 (27%), Positives = 561/1318 (42%), Gaps = 151/1318 (11%)

Query: 72   SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRL 131
            ++ E  PP T V  I A      +  G G+ +   + +S    D+     +G++     L
Sbjct: 244  NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI----SGVLTLNGLL 299

Query: 132  DRERRDHYSFVAATLLGAVVQVE-------------IRVNDVNDHSPRFPLDSLQLDVSE 178
            DRE   +      T+ G  +  +             I V D+ND++P F      + ++E
Sbjct: 300  DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359

Query: 179  LSPPGTAFRL---PVAHDPDAGLFSTQGYTLVQPSD-----LPKDPAGPFFQLRYRTPGP 230
            L+  G A  L    V  D + GL S     LV  +       P    G    +R R    
Sbjct: 360  LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA-DIRIRVA-- 416

Query: 231  LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290
                          PLD   + R D +  A   +         P   G   V++ +++EN
Sbjct: 417  -------------IPLDYETVDRYDFDLFANESV---------PDHVGYAKVKITLINEN 454

Query: 291  DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
            DN P+F Q  Y  ++ E+   G  V  V ATD D G  G V Y                 
Sbjct: 455  DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS-------------- 500

Query: 351  GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
             D   F++++ +G++ +   LD E      L + ARDGG E    T RV I VLDVNDN 
Sbjct: 501  DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNV 558

Query: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
            P     F  +  V  + E       + R+  +D D      ++ T  +        +S S
Sbjct: 559  PT----FQKDAYVGALRENEPSVTQLVRLRATDEDSP--PNNQITYSI--------VSAS 604

Query: 471  LEGGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLR 528
              G   D +L  G   GV  + V  PLD E  S  L  L ++A DAG+PPL++   + + 
Sbjct: 605  AFGSYFDISLYEGY--GV--ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660

Query: 529  VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
            V D ND PP FS+  Y  SV E    G  V++++A+D D +                   
Sbjct: 661  VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG--------------- 705

Query: 589  LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD--LGEPPLSAT 646
                Q  ++++ E    F I++ SG I+T   LDRE +    L V A D  +G    +  
Sbjct: 706  ----QESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI 761

Query: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
              V+IT+ D+NDN P +    Y   + E  P       V A D D G  G + YS+    
Sbjct: 762  ATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---- 817

Query: 707  LSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATYDLL----VEAKDGGG----LSAQA 755
               + P  F  ++   G+I  +   +DRE  DP   +L+    V   D G      ++ A
Sbjct: 818  ---QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874

Query: 756  FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815
             V V+L D+NDN P F    +V  + +    G  I  V+A D D G+ G V+Y +  G  
Sbjct: 875  TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934

Query: 816  SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
               F I+S++G++  T  L         L V A D G  T    + +TIH+         
Sbjct: 935  RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPT 994

Query: 876  FERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
            F    Y   V EDVP +  +  +   +  +  +  + Y I+ G++ GKFS+  R   +RT
Sbjct: 995  FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1054

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPA----CSSTEVNITVMDVNDNHPAFLRTSDEIRISQ 990
               LD ET    +L ++A + + P       +  V +TV+DVNDN P FL++S E  + +
Sbjct: 1055 VVGLDRETTAAYMLILEA-IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPE 1113

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQREL 1049
              P G ++   +A D D G  G + Y I     G  F I  + G+L + G      +R  
Sbjct: 1114 DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNS 1172

Query: 1050 T--LTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106
            +  L + A +  + P ++++ V+  V +  + +P +T +    ++ + E+    T ++  
Sbjct: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT-QQQYSRLGLRETAGIGTSVIVV 1231

Query: 1107 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
            QA           + Y +    +   F I   TG I      DYE+  +Y   V A    
Sbjct: 1232 QATD-RDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA 1289

Query: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
              F Q    +V + + +E D +  F +      + E+      I ++ A  +D+    Q+
Sbjct: 1290 PPFNQGF-CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQI 1346

Query: 1227 LY----FLLSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
             Y    +  +  K  FK++  TG +     +DRE    + +TV V D G P  ++T+ VY
Sbjct: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVY 1405

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
            ++V D NDN P F       +  V + E  PV   V TV A DPD G+N +V +S++S
Sbjct: 1406 ITVLDENDNSPRFDFT---SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460



 Score =  292 bits (747), Expect = 2e-78
 Identities = 300/1136 (26%), Positives = 467/1136 (41%), Gaps = 131/1136 (11%)

Query: 250  LLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS--VELRVLDENDNPPVFEQDEYRAAVRE 307
            L + LDRE  +   ++    D       G+++  V ++V D NDN P F    Y   + E
Sbjct: 89   LRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143

Query: 308  DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
            +   G  +  V ATD DLG  G V YS +                + +FA++   G+V V
Sbjct: 144  NTPVGTPIFIVNATDPDLGAGGSVLYSFQP--------------PSQFFAIDSARGIVTV 189

Query: 368  WRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
             R LD E    +QL V A D      ++T+  ++I + DV D  P    +F+       +
Sbjct: 190  IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNI 245

Query: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
             E + PG  V  ++  D D    +        G+G                + ++ G   
Sbjct: 246  YEHSPPGTTVRIITAIDQDKGRPR--------GIG----------------YTIVSGNTN 281

Query: 487  GVF-------FLCVEGPLDRESRDLYELLLVATDAGS--------PPLSTEETLLLRVAD 531
             +F        L + G LDRE+  LY    + T  G+           +   T  + V D
Sbjct: 282  SIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVID 340

Query: 532  LNDQPPLFSQQHYKASVSEAAAPG-TVVMWVSASDADE-AGSDHAWLRYTVVQLSAPCNL 589
            +ND  P F+   Y  +++E A  G  + +++   D DE  G +  +  Y V   S     
Sbjct: 341  INDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS----- 395

Query: 590  GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
                    H     P+         I     LD E  +  +  + A +   P       V
Sbjct: 396  --------HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKV 446

Query: 650  SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
             IT+ + NDN PIF + +YN ++ E+  VG   L V A+D D+G +G + Y   D     
Sbjct: 447  KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD---- 502

Query: 710  EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
              P  F +D   G I +   +D E     + L + A+DGGG      VR+++ DVNDN P
Sbjct: 503  --PDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRINVLDVNDNVP 559

Query: 770  VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV-SSLFTID--STTG 826
             F    YV ++ +     T+++ + ATD+DS     + Y ++  +   S F I      G
Sbjct: 560  TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619

Query: 827  IIYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
            +I ++ PL +  + +  + L V A D G         VTI +F     P  F +P Y   
Sbjct: 620  VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679

Query: 885  VYEDVPEDSPIGTVKA----REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 940
            V E++   + +  + A    R      E I Y +       +F I+ R G I T   LD 
Sbjct: 680  VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDR 736

Query: 941  ETQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
            ET+   +L V+A  G       T    VNIT++D+NDNHP +      I + + TPP + 
Sbjct: 737  ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796

Query: 998  LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVL-----FLNGSLGAGEQREL--T 1050
            +    A D D G NG + YSI  P    ++++   G +      L+       + EL   
Sbjct: 797  VTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855

Query: 1051 LTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 1107
            + +   D G  P  A    TV   +++  ++ P  TF++L +  EV E +     + Q  
Sbjct: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVV 913

Query: 1108 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167
            A  L  +     + Y +   +    F I   +G +    + D E    Y  RV A   + 
Sbjct: 914  AIDL-DEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDA 970

Query: 1168 GFLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
            G     ST T+ + V D ND +PTF   V  + V E    +  +  +   D D G N +L
Sbjct: 971  GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030

Query: 1227 LYFLLS---DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRG--SPPRNATMAVY 1281
             YF+     DGK F +      +   V LDRE    + + +   D G        T  V+
Sbjct: 1031 SYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            V+V D+NDNRP F Q          V E  P    +  + A D DEG    V Y +
Sbjct: 1090 VTVLDVNDNRPIFLQ----SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141



 Score =  284 bits (726), Expect = 5e-76
 Identities = 346/1296 (26%), Positives = 552/1296 (42%), Gaps = 160/1296 (12%)

Query: 103  LSEDSDDSPLLDD---------FHVHPDTGIIRTARRLDRERRDHYS--FVAATLLGAVV 151
            L++D D+ PL+           F V PDTG++   + LDRE +  ++  F  +   G + 
Sbjct: 56   LAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115

Query: 152  Q-VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
            + V I+V DVND++P F      + + E +P GT   +  A DPD G   +  Y+   PS
Sbjct: 116  RKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 175

Query: 211  DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
                     FF +               S+  +    + ++R LD E   A++L + A D
Sbjct: 176  Q--------FFAI--------------DSARGI----VTVIRELDYETTQAYQLTVNATD 209

Query: 271  GGRPR-RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNG 329
              + R  + L ++ + + D  D  P+F    Y   + E + PG  V  + A D+D G   
Sbjct: 210  QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269

Query: 330  FVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAW-HQLVVEAR-- 386
             + Y++    V G           + FA++ +SGV+ +   LDRE   + H  ++  +  
Sbjct: 270  GIGYTI----VSG--------NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317

Query: 387  ----DGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVS 442
                D        T   +I V+D+NDN P  +    +E  VA ++E A+ G +   + + 
Sbjct: 318  ELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SSEYSVA-ITELAQVG-FALPLFIQ 372

Query: 443  DADGDWEKEDEATGELGVGLGDGS----ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLD 498
              D D      +  E+ + +G+ S    IS +   G+ D  +            V  PLD
Sbjct: 373  VVDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIR-----------VAIPLD 420

Query: 499  RESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVV 558
             E+ D Y+  L A ++    +   +  +  + + ND  P+FSQ  Y  S+ E    GT V
Sbjct: 421  YETVDRYDFDLFANESVPDHVGYAKVKITLINE-NDNRPIFSQPLYNISLYENVTVGTSV 479

Query: 559  MWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTI 618
            + V A+D D                      G+        ++    F++D ++G I  I
Sbjct: 480  LTVLATDND---------------------AGTFGEVSYFFSDDPDRFSLDKDTGLIMLI 518

Query: 619  RTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPV 678
              LD E+ +   L ++A+D G      T  V I V DVNDN P F +  Y   + E+ P 
Sbjct: 519  ARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPS 576

Query: 679  GHCFLQVTASDADSGLYGFIEYSLY--DGFLSYEAPQAFRIDPHDGQ--ICVSQDIDRER 734
                +++ A+D DS     I YS+     F SY     F I  ++G   I VS+ +D E+
Sbjct: 577  VTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-----FDISLYEGYGVISVSRPLDYEQ 631

Query: 735  -DPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791
                   L V A D G   L++   V +++ D NDN P F+   Y  S+ +    G  ++
Sbjct: 632  ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691

Query: 792  NVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSA 848
             + ATD D S  YG  ++ Y L     S+ F I++ +G I  T  L     +   L+V A
Sbjct: 692  FLNATDLDRSREYGQESIIYSL---EGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748

Query: 849  QDGG----GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP- 903
             DGG      T +   ++T+        P   + P Y  LV E  P DS + TV A +P 
Sbjct: 749  VDGGVGHNQKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPD 806

Query: 904  LNSSEPIFYRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQ 953
            L  +  + Y I   +    +S++   G IRT         P  HE +    +VV      
Sbjct: 807  LGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864

Query: 954  LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
                 A SS  V + ++D+NDN P F        + +  P G ++Y   A D D G NGL
Sbjct: 865  RPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGL 924

Query: 1014 IRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071
            + Y +    P + F I+ + GV+     L      E  L + A D G   +++   LT+ 
Sbjct: 925  VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVD 1129
            V++  + +P  TF   VY V VSE +    ++  L    + +G     + L Y +     
Sbjct: 985  VLDVNDETP--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG---LNAELSYFITGGNV 1039

Query: 1130 SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED--GFLQNVSTTVIVRVWDENDN 1187
               F +      +      D E+T  Y   +   I     G     + TV V V D NDN
Sbjct: 1040 DGKFSVGYRDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098

Query: 1188 SPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTG 1244
             P FL       V E  +P+G  I ++ A D D G+ G++ Y +L  + G  F+++ + G
Sbjct: 1099 RPIFLQSSYEASVPED-IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157

Query: 1245 ELINWV-ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 1303
             L+     LDRE    H + V   +    P  +++ V V V DIND  P F Q    +  
Sbjct: 1158 LLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ---QQYS 1214

Query: 1304 HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             + + E   +   V  V A D D G+   V Y + S
Sbjct: 1215 RLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILS 1250



 Score =  272 bits (696), Expect = 1e-72
 Identities = 298/1103 (27%), Positives = 474/1103 (42%), Gaps = 137/1103 (12%)

Query: 305  VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA--YFAVEELS 362
            + ED   G+ V ++ A D D  P  F                 G  G+ A  +FAVE  +
Sbjct: 42   ISEDTPVGSSVTQLLAQDMDNDPLVF-----------------GVSGEEASRFFAVEPDT 84

Query: 363  GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGG 422
            GVV + +PLDRE ++   +     D      V T +V+I V DVNDN P  H     +  
Sbjct: 85   GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFH----NQPY 137

Query: 423  VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLP 482
              R+ E    G  +  V+ +D D            LG G   GS+  S +     FA+  
Sbjct: 138  SVRIPENTPVGTPIFIVNATDPD------------LGAG---GSVLYSFQPPSQFFAI-- 180

Query: 483  GGPPGVFFLCVEGPLDRESRDLYELLLVATDAG-SPPLSTEETLLLRVADLNDQPPLFSQ 541
                G+  +  E  LD E+   Y+L + ATD   + PLST   L + + D+ D  P+F  
Sbjct: 181  DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238

Query: 542  QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
              Y  ++ E + PGT V  ++A D D+       + YT+V                 +  
Sbjct: 239  LPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIV-----------------SGN 279

Query: 602  CGPSFAIDSESGAISTIRTLDRE---VQEAVELKVVAQDLGE----PPLSATCLVSITVD 654
                FA+D  SG ++    LDRE         L V   +L +       + T   +I V 
Sbjct: 280  TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHC---FLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
            D+NDN P F    Y+  I E A VG     F+QV   D + GL      S+++ +L    
Sbjct: 340  DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL-----NSMFEVYLVGNN 394

Query: 712  PQAFRIDP------HDGQICVSQDIDRER-DPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
               F I P       D +I V+  +D E  D   +DL         +   A V++ L + 
Sbjct: 395  SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV-GYAKVKITLINE 453

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
            NDN P+F+   Y  S+ +    GT ++ VLATD D+G +G V+Y     +    F++D  
Sbjct: 454  NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKD 511

Query: 825  TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
            TG+I L   L +      +L + A+DGGG        V I++         F++  Y   
Sbjct: 512  TGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQKDAYVGA 569

Query: 885  VYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKF---SIHPRLGTIRTRKPLDH 940
            + E+ P  + +  ++A  E    +  I Y I S    G +   S++   G I   +PLD+
Sbjct: 570  LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY 629

Query: 941  E--TQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
            E  +  ++ LTV A   G+ P  S+  V I V D NDN P F + +  + + +    G  
Sbjct: 630  EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689

Query: 998  LYLARAED----RDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
            +    A D    R+ G+  +I     S Q   F I+   G +     L    + E  L +
Sbjct: 690  VLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIV 746

Query: 1054 RAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
            RA D GV       + TV   +++  ++ P+W  +   Y + + E   P + +  T    
Sbjct: 747  RAVDGGVGHNQKTGIATVNITLLDINDNHPTW--KDAPYYINLVEMTPPDSDV--TTVVA 802

Query: 1111 LGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWI-YLRRQFDYESTQTYNF----RVFAWI 1164
            + P    +  L YS++P   +  + +   TG I       D E+   +      ++   +
Sbjct: 803  VDPDLGENGTLVYSIQP--PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSV 860

Query: 1165 PEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDS 1220
             + G        S TV V + D NDN PTF +     +V E  +P GV I ++ AID+D 
Sbjct: 861  TDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEG-IPAGVSIYQVVAIDLDE 919

Query: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G NG + Y +        F +N ++G ++    LDRE    +++ V+ +D G+P +++T 
Sbjct: 920  GLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979

Query: 1279 AVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             + + V D+ND  P FFP        +V V E  P    V  +   D D G NAE++Y +
Sbjct: 980  TLTIHVLDVNDETPTFFPAV-----YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034

Query: 1338 SSARPMPLKGKTAFGKQSCKKQT 1360
            +      + GK + G +    +T
Sbjct: 1035 TGGN---VDGKFSVGYRDAVVRT 1054



 Score =  261 bits (666), Expect = 4e-69
 Identities = 315/1218 (25%), Positives = 502/1218 (41%), Gaps = 148/1218 (12%)

Query: 102  FLSEDSDDSPL------------LDDFHVHPDTGIIRTAR--RLDRERRDHYSFVAATL- 146
            FL+ D D  P             L +F + P  G++R  +   LDRE    Y+       
Sbjct: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825

Query: 147  -----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFST 201
                 L + + V IRV D+ND+ P      + + +SE SP  +     +A D D+G  + 
Sbjct: 1826 RGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNAR 1885

Query: 202  QGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAA 261
              + +                    T G         +++ +  ++    R LDRE    
Sbjct: 1886 LTFNI--------------------TAGNRERAFFINATTGIVTVN----RPLDRERIPE 1921

Query: 262  HRLQIEAWDGGRPRRTGLLSVELRVL---DENDNPPVFEQDEYRAAVREDAQPGAEVCRV 318
            ++L I   D     R      +L ++   DENDN P+F +  Y+A V E++  G  +  +
Sbjct: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981

Query: 319  RATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP--LDREAQ 376
                  L  +  + Y+V   Q+ GA SG         F +   +GVV V     +DREA 
Sbjct: 1982 NGPILALDADQDI-YAVVTYQLLGAQSG--------LFDINSSTGVVTVRSGVIIDREAF 2032

Query: 377  AWH--QLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGD 434
            +    +L++ A D G     +T  + I +LD NDNRP      LT      + E   PG 
Sbjct: 2033 SPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFSPATLT----VHLLENCPPGF 2086

Query: 435  YVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVE 494
             V +V+ +D D               GL +G +   +E G  D  L+     GV  +   
Sbjct: 2087 SVLQVTATDEDS--------------GL-NGELVYRIEAGAQDRFLIHL-VTGVIRVG-N 2129

Query: 495  GPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAP 554
              +DRE ++ Y L +VATD G+ PLS    + + + D+ND  P F       SV E+A P
Sbjct: 2130 ATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189

Query: 555  GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA 614
            GTV+  ++A D D     +  L Y +V + A  +      ++V   E   +FA++  +G+
Sbjct: 2190 GTVIANITAIDHDL----NPKLEYHIVGIVAKDDT----DRLVPNQE--DAFAVNINTGS 2239

Query: 615  ISTIRTLDREVQEAVE--LKVV--AQDLGEPPLSA-TCLVSITVDDVNDNEPIFWR---Q 666
            +     ++RE+    E  L V+  A DL E  +S     +++ V DVNDN P F      
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299

Query: 667  VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD----GFLSYEAPQAFRIDPHDG 722
             Y   I E A  G   + V A D D GL G + Y+L D    G++  E       D   G
Sbjct: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-------DSSAG 2352

Query: 723  QICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSI 780
            ++  ++ +D E +    +  V A D G     A + V LE  D+NDN+P+F+  +Y  ++
Sbjct: 2353 KVIANRTVDYE-EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAV 2411

Query: 781  SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
             ++   GT I+ V ATD DSG +  + Y L  G+  S F I+ TTG IY+   L   +  
Sbjct: 2412 FEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKD 2469

Query: 841  TLSLMVSAQDGGGLTAVINAD----VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIG 896
               L   A+D  G  A    +    V I +        +F +P+++  VYE+ P  + + 
Sbjct: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529

Query: 897  TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS 956
            T+ A +              G     F +    G + T++PL    +   +  V    G 
Sbjct: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ-SYEKFSLTVVATDGGE 2588

Query: 957  APACSSTEVNITVMDVNDNHPAFLRTSDE--IRISQTTPPGTALYLARAEDRDSGRNGLI 1014
             P   +T + + V+DVNDN P F+R  +   + I +  P  + +Y   A D+D G NG +
Sbjct: 2589 PPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAV 2648

Query: 1015 RYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLVL 1069
            RYS            F ID   G++     L    Q   +L L A D G   P   +  L
Sbjct: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPL 2708

Query: 1070 TVVIEKREHSPSWTFE----HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL-RYSL 1124
             V +E  + +             YQ+      SP   ++      +      + +  Y +
Sbjct: 2709 QVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768

Query: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA-----WIPEDGFLQNVSTT--- 1176
                +   F ++P  G + + R  D E    ++F V A     W P  G    +      
Sbjct: 2769 AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827

Query: 1177 ----VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS 1232
                V V + D ND  P F        V         + ++ A+D D G N  + Y +L+
Sbjct: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILA 2887

Query: 1233 DGKFFKMNPNTGELINWV 1250
               +F+   N  E +  V
Sbjct: 2888 I-HYFRALANDSEDVGQV 2904



 Score =  213 bits (541), Expect = 1e-54
 Identities = 237/821 (28%), Positives = 351/821 (42%), Gaps = 148/821 (18%)

Query: 70   TLSVDEGLPPDTLVGDIRA---GLPAAQQQEGSGFFLSEDSDDS-PLLDD-FHVHPDTGI 124
            T+SV E   P T++ +I A    L    +    G    +D+D   P  +D F V+ +TG 
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239

Query: 125  IRTARRLDRERRDHYSFVAATLLGAV-----------VQVEIRVNDVNDHSPRFP---LD 170
            +     ++RE    Y    + +  A             ++ + V DVND++P+F    + 
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299

Query: 171  SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230
                 + E + PGT      A DPD GL     YTL+   DL   P G + QL   + G 
Sbjct: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---DLV--PPG-YVQLEDSSAGK 2353

Query: 231  LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290
            +                 +  R +D EE       + A D G P R   + V L ++D N
Sbjct: 2354 V-----------------IANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDIN 2396

Query: 291  DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
            DN P+F+Q  Y+ AV ED   G  +  V ATD D G    + YS               L
Sbjct: 2397 DNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYS---------------L 2441

Query: 351  GDA-AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG----GAEPEVATVRVSIAVLD 405
            GD  + FA+   +G + V   LDRE +  + L   A+D      +     +V+V I VLD
Sbjct: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL-GD 464
            VND RP     F        V E    G  V  +  +D D      +   GEL   L G 
Sbjct: 2502 VNDCRPQ----FSKPQFSTSVYENEPAGTSVITMMATDQD------EGPNGELTYSLEGP 2551

Query: 465  GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
            G  +  ++   G              +  + PL  +S + + L +VATD G PPL     
Sbjct: 2552 GVEAFHVDMDSG-------------LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTM 2596

Query: 525  LLLRVADLNDQPPLFSQQHYKA--SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
            LL+ V D+ND  P+F +        + E     + V  V A+D DE G + A +RY+ ++
Sbjct: 2597 LLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLK 2654

Query: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP- 641
             +     G+   +          F ID  SG I T + LDRE Q    L +VA DLG+P 
Sbjct: 2655 TA-----GNRDWEF---------FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700

Query: 642  PLSATCLVSITVDDVNDNEPIFWR------QVYNATIAEHAPVGHCFLQVT-ASDADSGL 694
            P      + + ++D++DNEP+F R      Q    T+ EH+P G     VT A DAD G 
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760

Query: 695  YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG------ 748
               + Y +  G       + F + P DG + V +D+DRER+ A +  +V+A         
Sbjct: 2761 NAIVYYFIAAG----NEEKNFHLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPP 2814

Query: 749  ----------GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798
                        L+ Q  VRV LED+ND  P F  + Y   ++ + + G+E+I VLA D 
Sbjct: 2815 RGPSPTLDLVADLTLQE-VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873

Query: 799  DSGIYGTVAYELI-----------PGNVSSLFTIDSTTGII 828
            D G    V Y ++             +V  +FT+ S  GI+
Sbjct: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914



 Score =  122 bits (306), Expect = 2e-27
 Identities = 127/483 (26%), Positives = 209/483 (43%), Gaps = 51/483 (10%)

Query: 884  LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 943
            L+ ED P  S +  + A++  N  +P+ + +S  +    F++ P  G +  R+PLD ET+
Sbjct: 41   LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98

Query: 944  PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003
                 TV+  +       + +VNI V DVNDN P F      +RI + TP GT +++  A
Sbjct: 99   S--EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156

Query: 1004 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 1062
             D D G  G + YS   P    FAID A G++ +   L     +   LT+ A DQ    P
Sbjct: 157  TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215

Query: 1063 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 1115
             + L  L ++I + ++  P   F +L Y   + E   P      +T + Q +  P G   
Sbjct: 216  LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270

Query: 1116 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 1165
                + Y++     +++F +   +G + L    D E+   Y+      +          P
Sbjct: 271  ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTP 325

Query: 1166 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 1222
             D     V+TT  + V D NDN+P F      + + E + V   +   I  +D D   G 
Sbjct: 326  SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382

Query: 1223 NGQL-LYFLLSDGKFFKMNPNTGE------LINWVALDREHRGHHEMTVLVTDRGSPPRN 1275
            N    +Y + ++   F ++P + +      +   + LD E    ++   L  +   P   
Sbjct: 383  NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHV 441

Query: 1276 ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
                V +++ + NDNRP F Q L     ++ + E   V   V TV A D D G   EV+Y
Sbjct: 442  GYAKVKITLINENDNRPIFSQPL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSY 497

Query: 1336 SVS 1338
              S
Sbjct: 498  FFS 500


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  357 bits (916), Expect = 4e-98
 Identities = 362/1288 (28%), Positives = 554/1288 (43%), Gaps = 123/1288 (9%)

Query: 65   QLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
            Q + +TLS  E     T V  +RA    ++   G  + +  +   S   D FHV   TG+
Sbjct: 2286 QSYAVTLS--EASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSH--DHFHVDSSTGL 2341

Query: 125  IRTARRLDRER-RDHYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
            I   R LD E+ R H  FV A       L + V V + V D+ND+ P F     +  +SE
Sbjct: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401

Query: 179  LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
             +P G       A+D D+       Y+++  +D         F +   T     S L   
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGND------HKHFVIDSATGIITLSNLHRH 2455

Query: 239  SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQ 298
            +  P   L+L +   + R     H                     + V+  N + P F Q
Sbjct: 2456 ALKPFYSLNLSVSDGVFRSSTQVH---------------------VTVIGGNLHSPAFLQ 2494

Query: 299  DEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY--F 356
            +EY   + E+A     V  V+ TD D G  G V Y +              + D A   F
Sbjct: 2495 NEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI--------------VNDFAKDRF 2540

Query: 357  AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
             + E  G +     LDRE  A   + V      A  +VA   V++ + D NDN P     
Sbjct: 2541 YINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQ---- 2595

Query: 417  FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
            F        +   A  G  V +V  SDAD    +   A     +     S+  +LE  + 
Sbjct: 2596 FRATKYEVNIGSSAAKGTSVVKVLASDAD----EGSNADITYAIEADSESVKENLEINK- 2650

Query: 477  DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                L G       +  +  L     + +   + A D GSP   +   + +++     Q 
Sbjct: 2651 ----LSG------VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL 2700

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P FS+  Y  +VSE    GT +  + A   + +G+    + Y++V+ + P          
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGT----VLYSLVKGNTP---------- 2743

Query: 597  VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ-DLGEPPLSATCLVSITVDD 655
               +    SF ID +SG +   ++LD E  +  +  ++A+    +  + A+  VSI V D
Sbjct: 2744 --ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKD 2801

Query: 656  VNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
             NDN P+F    Y A I E+ P G   +Q+ ASDADSG  G + YSL D   S E  ++F
Sbjct: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL-DQSQSVEVIESF 2860

Query: 716  RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFN 772
             I+   G I   +++D E+    Y + V A D G    LS+ A V V + DVND+ P F 
Sbjct: 2861 AINMETGWITTLKELDHEKRD-NYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSG-IYGTVAYELIPGNVSSLFTIDSTTGI--IY 829
               Y  ++S++   G  I  +  TD DS  I   V Y +  G+    F +++      +Y
Sbjct: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVY 2979

Query: 830  LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDV 889
            +  PL   +     L ++A DG   T    A V + +          E+  Y+  + EDV
Sbjct: 2980 VKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDV 3036

Query: 890  PEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVL 948
                 I  + A +  + S+  I Y +  G    KF ++P  G ++T  PLD E Q V  L
Sbjct: 3037 LPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAVYHL 3095

Query: 949  TVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDS 1008
             V+A  G    C ++ V +T+ DVNDN P F      I + + T PGT L   +A D D+
Sbjct: 3096 LVRATDGGGRFCQASIV-LTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA 3154

Query: 1009 GRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ--AAL 1066
            G N  I YS+     G F+I+   G++ L   L    Q   TL+L+A DQG+  +  A  
Sbjct: 3155 GLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATG 3214

Query: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
             V+  V++  ++ P   FE+  Y   VSE +   T++LQ  A     + A + + YS+  
Sbjct: 3215 TVIVSVLDINDNPP--VFEYREYGATVSEDILVGTEVLQVYAASRDIE-ANAEITYSIIS 3271

Query: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS--TTVIVRVWDE 1184
              +   F I   TG +++    DYES+  Y   V A    DG   ++S   TV V V D 
Sbjct: 3272 GNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEA---TDGGTPSLSDVATVNVNVTDI 3328

Query: 1185 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPN 1242
            NDN+P F  D     + E  V +  +  + A D D   N  + Y ++  + G  F ++P 
Sbjct: 3329 NDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPV 3388

Query: 1243 TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 1302
             GE+     LDRE    + +TV  +D GSPPR  T  V + V+D+NDN P F +      
Sbjct: 3389 RGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR----GN 3444

Query: 1303 LHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
              V + E +PV   V  +   D D  +N
Sbjct: 3445 YSVIIQENKPVGFSVLQLVVTDEDSSHN 3472



 Score =  354 bits (909), Expect = 3e-97
 Identities = 358/1266 (28%), Positives = 546/1266 (43%), Gaps = 154/1266 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPRFPL 169
            F +  +TG+++    LDRE  D Y+         + Q      + + V D ND+ P F  
Sbjct: 765  FMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ 824

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
            +S  ++VSE     +      A D D G      Y++V  +D         F +   T  
Sbjct: 825  ESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--------FSIDSVTG- 875

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR--PRRTGLLSVELRVL 287
                              + + R LDRE    H L+IEA D  R  P+    + V++ + 
Sbjct: 876  -----------------VVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918

Query: 288  DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
            D NDNPP F    YR  VRED   G  +  + A D DLG +G VRYS+      G G+  
Sbjct: 919  DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDH---GEGN-- 973

Query: 348  GALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV-ATVRVSIAVLDV 406
                    F V++LSG VR+ + LD E +  + L V A+D G    + +T  V + V+DV
Sbjct: 974  --------FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025

Query: 407  NDN-RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
            N+N  P +   F+ +G    V E A  G  V  VS  D D                  DG
Sbjct: 1026 NENLHPPVFSSFVEKG---TVKEDAPVGSLVMTVSAHDED---------------ARRDG 1067

Query: 466  SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
             I  S+  G G      G   GV  +     LDRES   Y L + ATD G  PLS+   +
Sbjct: 1068 EIRYSIRDGSGVGVFKIGEETGV--IETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEI 1125

Query: 526  LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
             + V D+ND  P  S+  Y   + E +     V+ + A D D + +D    + T      
Sbjct: 1126 YIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKIT------ 1179

Query: 586  PCNLGSLQSKMVHTAECGPSFAIDSESGAISTI-RTLDREVQEAVELKVVAQDLGEPPLS 644
                G+ Q            F+I  ++G I+T  R LDRE Q+   L+V   D G PP S
Sbjct: 1180 ---SGNPQG----------FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKS 1226

Query: 645  ATCLVSITVDDVNDNEPIFWRQVYNATI-----------AEHAPVGHCFLQVTASDADSG 693
                V + + D NDN+P F ++ Y   +           A   P+ H    V A+D D G
Sbjct: 1227 TIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYH----VIATDKDEG 1282

Query: 694  LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAKDGGGLS 752
                I YS+ DG         F I+P  G +       R      YD+L ++A D G   
Sbjct: 1283 PNAEISYSIEDG----NEHGKFFIEPKTGVV----SSKRFSAAGEYDILSIKAVDNGRPQ 1334

Query: 753  AQAFVRVDLEDVNDNHPVFNP----STYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808
              +  R+ +E ++   P   P     ++ T    E+ P   +I V++  +  GI   + +
Sbjct: 1335 KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISV-EPPGI--PLWF 1391

Query: 809  ELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 868
            ++  GN  S F +D  TG I +  PL   + +  +L V A DG   T  I   V I +  
Sbjct: 1392 DITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVID 1448

Query: 869  TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG--KFSIH 926
            T     +F   KY  ++ ED   ++ I  + A +    ++ I+   SS D     KF + 
Sbjct: 1449 TNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLD 1508

Query: 927  PRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDE 985
            P  G++ T + LDHE      LTV  +    P   +   + + V D ND+ P F  +S +
Sbjct: 1509 PATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK 1568

Query: 986  IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 1044
             R+ ++   G+ +    A D+D G+N  + YSI S   G  F ID  LG +     L   
Sbjct: 1569 GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRS 1628

Query: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREH-SPSWTFEHLVYQVEVSESLSPMTQM 1103
             Q E  L ++A D+G  P + +  + + +   ++ SP +T +   Y VE+SE++S  + +
Sbjct: 1629 NQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE--YSVELSETVSIGSFV 1686

Query: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
                AH      + S + Y ++       F I P++G I  ++  D+E+   Y   +   
Sbjct: 1687 GMVTAH------SQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTL-IIQG 1739

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK-------ITAI 1216
                G   N  TTV+V + DENDN+P F+       + ES     V+         I A 
Sbjct: 1740 TNMAGLSTN--TTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAA 1797

Query: 1217 DMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR 1274
            D D   N  L+Y ++  S   +F ++ +TG +   ++LD E       TV V D G+P  
Sbjct: 1798 DADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRL 1857

Query: 1275 NATMA--VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAE 1332
             A  A  V V V DIND  P F + L    L +   +G    + V TV A D D    ++
Sbjct: 1858 FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKG----VKVITVNATDADSSAFSQ 1913

Query: 1333 VTYSVS 1338
            + YS++
Sbjct: 1914 LIYSIT 1919



 Score =  352 bits (903), Expect = 1e-96
 Identities = 356/1321 (26%), Positives = 574/1321 (43%), Gaps = 147/1321 (11%)

Query: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
            + E  PP+T V  ++A +PA          L      +P    F ++ +TG+I     + 
Sbjct: 376  ISEFAPPNTPVVMVKA-IPAYSH-------LRYVFKSTPGKAKFSLNYNTGLISILEPVK 427

Query: 133  RERRDHYSFVAATL-LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191
            R++  H+     T    A  +V ++V   N + P F   + +    E  P GT      A
Sbjct: 428  RQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487

Query: 192  HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLL 251
             DPD G      Y++   + +P       F + + T          G+ S  E LD  L+
Sbjct: 488  VDPDEGENGYVTYSIANLNHVP-------FAIDHFT----------GAVSTSENLDYELM 530

Query: 252  RRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQ 310
             R+       + L+I A D G P RR   +   + + + NDN P+FE+      +  D  
Sbjct: 531  PRV-------YTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLG 583

Query: 311  PGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP 370
             G ++  V A D D      V+Y + A              +  +F++   SGV+ + R 
Sbjct: 584  VGEQITTVSAIDAD--ELQLVQYQIEAGN------------ELDFFSLNPNSGVLSLKRS 629

Query: 371  LDREAQA---WHQLVVEARDGG--AEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425
            L     A   +H L + A DG   A P    + V+ +   VN       V  +    + +
Sbjct: 630  LMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689

Query: 426  VSEGARPGD-------------YVARVSVSDADGDWEKEDEATG---------ELGVGLG 463
             ++    G+             ++ +   +   G   KE++  G         +L  G  
Sbjct: 690  ANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGF- 748

Query: 464  DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE 523
            +G +  ++ GG  D   +     G+  L +  PLDRE+ D Y L +   D G P  +   
Sbjct: 749  NGKLVYAVSGGNEDSCFMIDMETGM--LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806

Query: 524  TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
             L + V D ND PP F Q+ Y   VSE     + ++ V A+D D   + H  + Y++V  
Sbjct: 807  LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGH--VTYSIVTD 864

Query: 584  SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG--EP 641
            +                    +F+IDS +G ++  R LDRE+Q    LK+ A+D    EP
Sbjct: 865  T-------------------DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEP 905

Query: 642  PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
             L +T +V ++++DVNDN P F    Y   + E  P G   + + A D D G  G + YS
Sbjct: 906  QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVR 758
            L D          F +D   G + + Q +D E+    Y+L V AKD G    LS+  +V 
Sbjct: 966  LLD-----HGEGNFDVDKLSGAVRIVQQLDFEKKQV-YNLTVRAKDKGKPVSLSSTCYVE 1019

Query: 759  VDLEDVNDN--HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            V++ DVN+N   PVF+      ++ ++   G+ ++ V A D+D+   G + Y +  G+  
Sbjct: 1020 VEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGV 1079

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
             +F I   TG+I  +  L    ++   L V A D G +      ++ I +        + 
Sbjct: 1080 GVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQT 1139

Query: 877  ERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTIRTR 935
              P Y   + E+ P+D  +  ++A +P +SS + + Y+I+SG+  G FSIHP+ G I T 
Sbjct: 1140 SEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTT 1199

Query: 936  -KPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
             + LD E Q   +L V     GS P  +   V + ++D NDN P FL+   +IR+ +   
Sbjct: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREK 1259

Query: 994  PGTA-------LYLARAEDRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGE 1045
            P          LY   A D+D G N  I YSI    + G F I+   GV+       AGE
Sbjct: 1260 PDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGE 1319

Query: 1046 QRELTLTLRAEDQGVHPQAALLVLTV--VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
                 L+++A D G   +++   L +  + + +      +FE   +   V ES  P+  M
Sbjct: 1320 YD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMES-DPVAHM 1376

Query: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
            +      +  +    PL + +      + F +   TG I + +  D E    YN  V A 
Sbjct: 1377 IGV----ISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA- 1431

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
               DG    + T V ++V D ND+ P F      + + E   P+  I +I+A+D D  + 
Sbjct: 1432 --TDG-TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EK 1486

Query: 1224 GQLLYFLLSDG-----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
             +L+Y L S       K F+++P TG L     LD E    H +TV+V D+  P +    
Sbjct: 1487 NKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFA 1546

Query: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
             + V+V+D ND+ P+F           +V E   V  +V  V A D D+G NAEV YS+ 
Sbjct: 1547 RIVVNVSDTNDHAPWFT----ASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIE 1602

Query: 1339 S 1339
            S
Sbjct: 1603 S 1603



 Score =  309 bits (792), Expect = 1e-83
 Identities = 324/1241 (26%), Positives = 533/1241 (42%), Gaps = 115/1241 (9%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSF---VAATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
            F +   TGII  +       +  YS    V+  +  +  QV + V   N HSP F  +  
Sbjct: 2438 FVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEY 2497

Query: 173  QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
            +++++E +P  T        D D+G++    Y +V  +D  KD     F +  R      
Sbjct: 2498 EVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIV--NDFAKDR----FYINERG----- 2546

Query: 233  SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
                           +  L +LDRE  A   + +         +    +V + + D+NDN
Sbjct: 2547 --------------QIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDN 2592

Query: 293  PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
             P F   +Y   +   A  G  V +V A+D D G N  + Y++ A       +       
Sbjct: 2593 APQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKEN------- 2645

Query: 353  AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
                 + +LSGV+     L      +    V A D G+  + + V V + +L      P 
Sbjct: 2646 ---LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPK 2702

Query: 413  IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
                F T      VSE    G  +  +             E +G +   L  G+   S  
Sbjct: 2703 FSEPFYT----FTVSEDVPIGTEIDLIRA-----------EHSGTVLYSLVKGNTPES-- 2745

Query: 473  GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT-DAGSPPLSTEETLLLRVAD 531
                D + +     G   L +E  LD E+   Y+  ++A        +     + ++V D
Sbjct: 2746 --NRDESFVIDRQSGR--LKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKD 2801

Query: 532  LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
             ND  P+F    Y+A + E    G+ V+ + ASDAD   +                    
Sbjct: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLD------------ 2849

Query: 592  LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVS 650
             QS+ V   E   SFAI+ E+G I+T++ LD E ++  ++KVVA D GE   LS+T +V 
Sbjct: 2850 -QSQSVEVIE---SFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVD 2905

Query: 651  ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG-LYGFIEYSLYDGF-LS 708
            +TV DVND+ P F  ++Y  T++E  P G     ++ +DADS  +   + Y +  G  L 
Sbjct: 2906 VTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLG 2965

Query: 709  YEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH 768
              A +  +   ++ ++ V + +DRE+    Y L + A DG   S++A V V + D NDN 
Sbjct: 2966 QFAVETIQ---NEWKVYVKKPLDREKRD-NYLLTITATDGT-FSSKAIVEVKVLDANDNS 3020

Query: 769  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGII 828
            PV   + Y  +I ++  PG  I+ + ATD D      + Y L+ G+ +  F ++  TG +
Sbjct: 3021 PVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGEL 3079

Query: 829  YLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 888
              + PL   E     L+V A DGGG      A + + +        EF    Y   V+E+
Sbjct: 3080 KTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFSADPYAITVFEN 3137

Query: 889  VPEDSPIGTVKAREP-LNSSEPIFYR-ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
                + +  V+A +     +  I Y  I S D  G+FSI+   G I+  KPLD E Q V 
Sbjct: 3138 TEPGTLLTRVQATDADAGLNRKILYSLIDSAD--GQFSINELSGIIQLEKPLDRELQAVY 3195

Query: 947  VLTVQAQLGSAPA--CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
             L+++A     P    ++  V ++V+D+NDN P F        +S+    GT +    A 
Sbjct: 3196 TLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAA 3255

Query: 1005 DRDSGRNGLIRYSIASP-QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
             RD   N  I YSI S  + G F+ID   G +F+  +L      E  LT+ A D G    
Sbjct: 3256 SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSL 3315

Query: 1064 AALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL-GPQRAASPLR 1121
            + +  + V V +  +++P   F    Y   +SE       ++   A    GP    S + 
Sbjct: 3316 SDVATVNVNVTDINDNTP--VFSQDTYTTVISEDAVLEQSVITVMADDADGPSN--SHIH 3371

Query: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VR 1180
            YS+      + F I P  G + + +  D E+   Y   V A   ++G    V+TT + + 
Sbjct: 3372 YSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA--SDNGSPPRVNTTTVNID 3429

Query: 1181 VWDENDNSPTFLHDVLFLKVEES-PVPQGVIGKITAIDMDSGKNGQLLYFLL---SDGKF 1236
            V D NDN+P F      + ++E+ PV   V+ ++   D DS  NG   +F +   +D K 
Sbjct: 3430 VSDVNDNAPVFSRGNYSVIIQENKPVGFSVL-QLVVTDEDSSHNGPPFFFTIVTGNDEKA 3488

Query: 1237 FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
            F++NP  G L+   A+ R+ + H+ + V V D G P    +   Y+ +  I ++   +P 
Sbjct: 3489 FEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYIDIRVIEES--IYPP 3543

Query: 1297 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             +   E+ +     +    ++  + A D D  +   +TYS+
Sbjct: 3544 AILPLEIFITSSGEEYSGGVIGKIHATDQDVYDT--LTYSL 3582



 Score =  309 bits (791), Expect = 1e-83
 Identities = 307/1080 (28%), Positives = 482/1080 (44%), Gaps = 115/1080 (10%)

Query: 92   AAQQQEGSGFFLSE--DSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG- 148
            A+   EGS   ++   ++D   + ++  ++  +G+I T   L     + ++F    +   
Sbjct: 2620 ASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNG 2679

Query: 149  -----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQG 203
                 +VV V +++       P+F        VSE  P GT   L  A      L     
Sbjct: 2680 SPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL----- 2734

Query: 204  YTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHR 263
            Y+LV+  + P+      F +  R  G L                  L + LD E    ++
Sbjct: 2735 YSLVK-GNTPESNRDESFVID-RQSGRLK-----------------LEKSLDHETTKWYQ 2775

Query: 264  LQIEA-WDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATD 322
              I A            + V ++V D NDN PVFE   Y A + E+   G+ V ++RA+D
Sbjct: 2776 FSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASD 2835

Query: 323  RDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLV 382
             D G NG V YS+   Q         ++     FA+   +G +   + LD E +  +Q+ 
Sbjct: 2836 ADSGTNGQVMYSLDQSQ---------SVEVIESFAINMETGWITTLKELDHEKRDNYQIK 2886

Query: 383  VEARDGGAEPEVA-TVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSV 441
            V A D G + +++ T  V + V DVND+ P     F  E     VSE    G  +A +S 
Sbjct: 2887 VVASDHGEKIQLSSTAIVDVTVTDVNDSPPR----FTAEIYKGTVSEDDPQGGVIAILST 2942

Query: 442  SDADGDWEKEDEATGELGVGLGDGSISLSLEGGE--GDFALLPGGPPGVFFLCVEGPLDR 499
            +DAD +         E+     +  ++  + GG+  G FA+        + + V+ PLDR
Sbjct: 2943 TDADSE---------EI-----NRQVTYFITGGDPLGQFAVET--IQNEWKVYVKKPLDR 2986

Query: 500  ESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVM 559
            E RD Y L + ATD      S++  + ++V D ND  P+  +  Y  ++ E   PG ++M
Sbjct: 2987 EKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM 3043

Query: 560  WVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR 619
             +SA+DAD   +  A + YT+        LGS   K          F ++ ++G + T  
Sbjct: 3044 QISATDADIRSN--AEITYTL--------LGSGAEK----------FKLNPDTGELKTST 3083

Query: 620  TLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
             LDRE Q    L V A D G     A+  + +T++DVNDN P F    Y  T+ E+   G
Sbjct: 3084 PLDREEQAVYHLLVRATDGGGRFCQAS--IVLTLEDVNDNAPEFSADPYAITVFENTEPG 3141

Query: 680  HCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATY 739
                +V A+DAD+GL   I YSL D      A   F I+   G I + + +DRE   A Y
Sbjct: 3142 TLLTRVQATDADAGLNRKILYSLIDS-----ADGQFSINELSGIIQLEKPLDRELQ-AVY 3195

Query: 740  DLLVEAKDGG---GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT 796
             L ++A D G    L+A   V V + D+NDN PVF    Y  ++S++   GTE++ V A 
Sbjct: 3196 TLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAA 3255

Query: 797  DQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTA 856
             +D      + Y +I GN    F+IDS TG +++   L +  S    L V A DGG  + 
Sbjct: 3256 SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSL 3315

Query: 857  VINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE---PLNSSEPIFYR 913
               A V +++         F +  YT ++ ED   +  + TV A +   P NS   I Y 
Sbjct: 3316 SDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH--IHYS 3373

Query: 914  ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDV 972
            I  G+ G  F+I P  G ++  K LD ET     LTVQA   GS P  ++T VNI V DV
Sbjct: 3374 IIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDV 3433

Query: 973  NDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG--LIRYSIASPQPGVFAIDR 1030
            NDN P F R +  + I +  P G ++      D DS  NG       +       F ++ 
Sbjct: 3434 NDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVN- 3492

Query: 1031 ALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVY 1089
              GVL  + ++   E+    L ++  D G    ++L  + + VIE+  + P+     L  
Sbjct: 3493 PQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA----ILPL 3548

Query: 1090 QVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149
            ++ ++ S    +  +  + H    Q     L YSL+P +D+ +F +    G +   ++ D
Sbjct: 3549 EIFITSSGEEYSGGVIGKIHAT-DQDVYDTLTYSLDPQMDN-LFSVSSTGGKLIAHKKLD 3606



 Score =  284 bits (727), Expect = 4e-76
 Identities = 332/1201 (27%), Positives = 508/1201 (42%), Gaps = 156/1201 (12%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSP 165
            D F +   TG++  AR LDRE +  +S              L + V V++ + DVND+ P
Sbjct: 866  DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925

Query: 166  RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
             F   + ++ V E  P GT      AHDPD G      Y+L+   +              
Sbjct: 926  TFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGE-------------- 971

Query: 226  RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVEL 284
               G      L G+        + ++++LD E+   + L + A D G+P   +    VE+
Sbjct: 972  ---GNFDVDKLSGA--------VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV 1020

Query: 285  RVLDENDN--PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPG 342
             V+D N+N  PPVF     +  V+EDA  G+ V  V A D D   +G +RYS+R      
Sbjct: 1021 EVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR------ 1074

Query: 343  AGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIA 402
             GSG G       F + E +GV+     LDRE+ + + L V A D G  P  + + + I 
Sbjct: 1075 DGSGVGV------FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128

Query: 403  VLDVNDNRP-AIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVG 461
            V DVNDN P     ++  E     + E + P D V+ V +   D D    D+   ++  G
Sbjct: 1129 VEDVNDNAPQTSEPVYYPE-----IMENS-PKD-VSVVQIEAFDPDSSSNDKLMYKITSG 1181

Query: 462  LGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLST 521
               G  S+  + G                      LDRE +D + L +  TD GSPP ST
Sbjct: 1182 NPQGFFSIHPKTG--------------LITTTSRKLDREQQDEHILEVTVTDNGSPPKST 1227

Query: 522  EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPG-------TVVMWVSASDADEAGSDHA 574
               +++++ D ND  P F Q+ YK  + E   P          +  V A+D DE    +A
Sbjct: 1228 IARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDE--GPNA 1285

Query: 575  WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
             + Y++         G+   K          F I+ ++G +S+ R       + + +K V
Sbjct: 1286 EISYSIED-------GNEHGK----------FFIEPKTGVVSSKRFSAAGEYDILSIKAV 1328

Query: 635  AQDLGEPPLSATCLVSI--TVDDVNDNEPI-FWRQVYNATIAEHAPVGHCFLQVTASDAD 691
              D G P  S+T  + I          EPI F    +  T+ E  PV H    ++     
Sbjct: 1329 --DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPG 1386

Query: 692  SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG-GG 750
              L+  I    YD          F +D   G I V++ +D E+  + Y+L VEA DG   
Sbjct: 1387 IPLWFDITGGNYDSH--------FDVDKGTGTIIVAKPLDAEQ-KSNYNLTVEATDGTTT 1437

Query: 751  LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD--SGIYGTVAY 808
            +  Q F++V   D ND+ P F+ S Y   I ++T P TEI+ + A DQD  + +  T+  
Sbjct: 1438 ILTQVFIKV--IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQS 1495

Query: 809  ELIPGNVSSLFTIDSTTGIIYLTLPLSH--LESTTLSLMVSAQDGGGLTAVIN-ADVTIH 865
               P ++   F +D  TG +Y +  L H  +   TL++MV  QD   +    N A + ++
Sbjct: 1496 SRDPLSLKK-FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD---VPVKRNFARIVVN 1551

Query: 866  IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFS 924
            +  T      F    Y   VYE     S +  V A +     +  + Y I SG++G  F 
Sbjct: 1552 VSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFM 1611

Query: 925  IHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTS 983
            I P LG+I+T K LD   Q    L V+A   GS P    T V I V   ++  P F    
Sbjct: 1612 IDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKE 1671

Query: 984  DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLG 1042
              + +S+T   G+ + +  A  + S     + Y I     G  F I+   G +    +L 
Sbjct: 1672 YSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKALD 1726

Query: 1043 AGEQRELTLTLRAEDQGVHPQAALLVLTVVIE-KREHSPSWTFEHLVYQVEVSESLSPMT 1101
                   TL +    QG +        TV++  + E+  +  F    Y   +SES S  +
Sbjct: 1727 FETLPIYTLII----QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINS 1782

Query: 1102 QMLQTQAHPLGPQRA-------ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQ 1154
             +L  +  PL  + A       A  + + +EPSV +  F I   TG I+     DYE T 
Sbjct: 1783 VVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHT-YFAIDSSTGAIHTVLSLDYEETS 1841

Query: 1155 TYNFRVFAW-IPEDGFLQNVSTTVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGV- 1209
             ++F V    +         +  V V V D ND  P F   L++   L     P  +GV 
Sbjct: 1842 IFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLL----LPTYKGVK 1897

Query: 1210 IGKITAIDMDSGKNGQLLYFLLSD--GKFFKMNPNTGELINWVALDREHRGHHEMTVLVT 1267
            +  + A D DS    QL+Y +     G+ F M+  TG L   V    + R  +E+TV  +
Sbjct: 1898 VITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT--VQNTTQLRSRYELTVRAS 1955

Query: 1268 D 1268
            D
Sbjct: 1956 D 1956



 Score =  283 bits (724), Expect = 8e-76
 Identities = 329/1286 (25%), Positives = 526/1286 (40%), Gaps = 181/1286 (14%)

Query: 131  LDRERRDHYSFVAATL-----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
            L+RE +DHY+ +   L     + A  +V ++V D ND  P F   S  + + E +   T+
Sbjct: 108  LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167

Query: 186  FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
                 A D D G      Y+    +D+        F + + T G                
Sbjct: 168  IARVSATDADIGTNGEFYYSFKDRTDM--------FAI-HPTSGV--------------- 203

Query: 246  LDLVLLRRLDREEAAAHRLQIEAWDGGRPRR-----TGLLSVELRVLDENDNPPVFEQDE 300
              +VL  RLD  E   + ++I A D G         + +  + + +   N+  PV     
Sbjct: 204  --IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261

Query: 301  YRAAVREDAQPGAEVCRVRATDRDLGPNG-FVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
               +   D  P   +  V   D D G NG     S+ A  +        +   +  + V+
Sbjct: 262  LSPS-ELDRDPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318

Query: 360  ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLT 419
             + G+     P        + L ++A+D G  P+ ++V+V   +   +    A  V F  
Sbjct: 319  AIGGIDWDSHPFG------YNLTLQAKDKGTPPQFSSVKV---IHVTSPQFKAGPVKFEK 369

Query: 420  EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
            +   A +SE A P   V  V    A        ++T         G    SL    G  +
Sbjct: 370  DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKST--------PGKAKFSLNYNTGLIS 421

Query: 480  LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
            +L              P+ R+    +EL +  +D           +L++V   N  PP F
Sbjct: 422  ILE-------------PVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEF 463

Query: 540  SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
            +Q  YKA+  E    GT VM +SA D DE   ++ ++ Y++  L+             H 
Sbjct: 464  TQTAYKAAFDENVPIGTTVMSLSAVDPDE--GENGYVTYSIANLN-------------HV 508

Query: 600  AECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQDLGEP-PLSATCLVSITVDDVN 657
                  FAID  +GA+ST   LD E+   V  L++ A D G P       L +IT++++N
Sbjct: 509  -----PFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLN 563

Query: 658  DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
            DN P+F +     TI     VG     V+A DAD      ++Y +  G         F +
Sbjct: 564  DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAG----NELDFFSL 617

Query: 718  DPHDGQICVSQDI--DRERDPATYDLLVEAKDGGGLSAQAFVRV---------------- 759
            +P+ G + + + +        + + L + A DG   +   ++ +                
Sbjct: 618  NPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEET 677

Query: 760  ---------------------------DLEDVNDNHPVFNPSTYVTSIS-DETQP-GTEI 790
                                       D   VN + P F  ST  T I   E QP G+ +
Sbjct: 678  GVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR-STLPTGIQVKENQPVGSSV 736

Query: 791  INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQD 850
            I + +TD D+G  G + Y +  GN  S F ID  TG++ +  PL    +   +L ++  D
Sbjct: 737  IFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYD 796

Query: 851  GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEP 909
             G         + + +      P EF +  Y   V ED    S I  V+A +  L  +  
Sbjct: 797  LGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGH 856

Query: 910  IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSST-EVN 966
            + Y I +      FSI    G +   +PLD E Q    L ++A  Q    P   ST  V 
Sbjct: 857  VTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVK 914

Query: 967  ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVF 1026
            +++ DVNDN P F+  +  +++ +  P GT +    A D D G++G +RYS+     G F
Sbjct: 915  VSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNF 974

Query: 1027 AIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTF 1084
             +D+  G + +   L   +++   LT+RA+D+G  V   +   V   V++  E+     F
Sbjct: 975  DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVF 1034

Query: 1085 EHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL 1144
               V +  V E     + ++   AH    +R    +RYS+       +F I   TG I  
Sbjct: 1035 SSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGE-IRYSIRDGSGVGVFKIGEETGVIET 1093

Query: 1145 RRQFDYESTQTYNFRVFAW----IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV 1200
              + D EST  Y   VFA     +P   F++     + + V D NDN+P     V + ++
Sbjct: 1094 SDRLDRESTSHYWLTVFATDQGVVPLSSFIE-----IYIEVEDVNDNAPQTSEPVYYPEI 1148

Query: 1201 EESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGELINWVA--LDREH 1256
             E+      + +I A D DS  N +L+Y + S     FF ++P TG LI   +  LDRE 
Sbjct: 1149 MENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG-LITTTSRKLDREQ 1207

Query: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP-----FFPQCLPGKELHVKVLEGQ 1311
            +  H + V VTD GSPP++    V V + D NDN+P     F+   LP +E   +  E  
Sbjct: 1208 QDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDR--ERN 1265

Query: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV 1337
                 +  V A D DEG NAE++YS+
Sbjct: 1266 ARREPLYHVIATDKDEGPNAEISYSI 1291



 Score =  282 bits (721), Expect = 2e-75
 Identities = 279/996 (28%), Positives = 427/996 (42%), Gaps = 115/996 (11%)

Query: 70   TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSE----DSDDSPLLDDFHVHPDTGII 125
            T +V E +P  T +  IRA        E SG  L      ++ +S   + F +   +G +
Sbjct: 2709 TFTVSEDVPIGTEIDLIRA--------EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL 2760

Query: 126  RTARRLDRERRDHYSFVAATL-------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
            +  + LD E    Y F            + A V V I+V D ND+SP F     +  + E
Sbjct: 2761 KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE 2820

Query: 179  LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
              P G+      A D D+G      Y+L Q   +                      ++  
Sbjct: 2821 NLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV---------------------EVIES 2859

Query: 239  SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD-GGRPRRTGLLSVELRVLDENDNPPVFE 297
             +  +E   +  L+ LD E+   +++++ A D G + + +    V++ V D ND+PP F 
Sbjct: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919

Query: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357
             + Y+  V ED   G  +  +  TD D             RQV    +GG  LG    FA
Sbjct: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEIN--------RQVTYFITGGDPLGQ---FA 2968

Query: 358  VEELSGVVRVW--RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
            VE +    +V+  +PLDRE +  + L + A DG    +     V + VLD NDN P    
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAI---VEVKVLDANDNSPVCEK 3025

Query: 416  LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGE 475
               ++     + E   PG  + ++S +DA  D     E T  L   LG G+    L    
Sbjct: 3026 TLYSD----TIPEDVLPGKLIMQISATDA--DIRSNAEITYTL---LGSGAEKFKLNPDT 3076

Query: 476  GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQ 535
            G+             L    PLDRE + +Y LL+ ATD G      + +++L + D+ND 
Sbjct: 3077 GE-------------LKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDN 3121

Query: 536  PPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSK 595
             P FS   Y  +V E   PGT++  V A+DAD AG +   L Y+++              
Sbjct: 3122 APEFSADPYAITVFENTEPGTLLTRVQATDAD-AGLNRKIL-YSLID------------- 3166

Query: 596  MVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP-PLSATCLVSITVD 654
                      F+I+  SG I   + LDRE+Q    L + A D G P  L+AT  V ++V 
Sbjct: 3167 -----SADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL 3221

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
            D+NDN P+F  + Y AT++E   VG   LQV A+  D      I YS+  G         
Sbjct: 3222 DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISG----NEHGK 3277

Query: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772
            F ID   G + + +++D E     Y L VEA DGG   LS  A V V++ D+NDN PVF+
Sbjct: 3278 FSIDSKTGAVFIIENLDYESSHEYY-LTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTL 832
              TY T IS++      +I V+A D D      + Y +I GN  S FTID   G + +T 
Sbjct: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK 3396

Query: 833  PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED 892
             L     +  +L V A D G    V    V I +         F R  Y+ ++ E+ P  
Sbjct: 3397 LLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVG 3456

Query: 893  SPI--GTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTV 950
              +    V   +  ++  P F+ I +G+    F ++P+ G + T   +  + +   +L V
Sbjct: 3457 FSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQV 3515

Query: 951  QAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
            +      P  SS T ++I V++ +   PA L     I  S     G  +    A D+D  
Sbjct: 3516 KVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV- 3574

Query: 1010 RNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE 1045
                + YS+      +F++    G L  +  L  G+
Sbjct: 3575 -YDTLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQ 3609



 Score =  280 bits (716), Expect = 7e-75
 Identities = 311/1117 (27%), Positives = 484/1117 (43%), Gaps = 118/1117 (10%)

Query: 254  LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGA 313
            LD E   A++L I A D        +  V++ V D NDNPPVF Q  Y   + E +  G 
Sbjct: 2242 LDFEAHPAYKLSIRATDSLTGAHAEVF-VDIIVDDINDNPPVFAQQSYAVTLSEASVIGT 2300

Query: 314  EVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDR 373
             V +VRATD D  PN  + Y +           G       +F V+  +G++ + R LD 
Sbjct: 2301 SVVQVRATDSDSEPNRGISYQMF----------GNHSKSHDHFHVDSSTGLISLLRTLDY 2350

Query: 374  EAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPG 433
            E    H + V A DGG     + V V++ V D+NDN P    LF  +   AR+SE A  G
Sbjct: 2351 EQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPP----LFEQQIYEARISEHAPHG 2406

Query: 434  DYVARVSVSDADG-DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLC 492
             +V  V   DAD  D +K                +  S+  G      +     G+  L 
Sbjct: 2407 HFVTCVKAYDADSSDIDK----------------LQYSILSGNDHKHFVIDSATGIITL- 2449

Query: 493  VEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAA 552
                L R +   +  L ++   G    ST+  + +   +L+   P F Q  Y+  ++E A
Sbjct: 2450 --SNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHS--PAFLQNEYEVELAENA 2505

Query: 553  APGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAID--- 609
               T+VM V  +D D     H  + Y +V                        FA D   
Sbjct: 2506 PLHTLVMEVKTTDGDSGIYGH--VTYHIVN----------------------DFAKDRFY 2541

Query: 610  -SESGAISTIRTLDREV--QEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
             +E G I T+  LDRE   ++ + ++++A+D G     A C V++ + D NDN P F   
Sbjct: 2542 INERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKV--AFCTVNVILTDDNDNAPQFRAT 2599

Query: 667  VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
             Y   I   A  G   ++V ASDAD G    I Y++     S    +   I+   G I  
Sbjct: 2600 KYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD--SESVKENLEINKLSGVITT 2657

Query: 727  SQD-IDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH--PVFNPSTYVTSISDE 783
             +  I  E +  T+   V A D G  S ++ V V ++ +      P F+   Y  ++S++
Sbjct: 2658 KESLIGLENEFFTF--FVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSED 2715

Query: 784  TQPGTEIINVLATDQDSGIYGTVAYELIPGNV-----SSLFTIDSTTGIIYLTLPLSHLE 838
               GTEI  + A        GTV Y L+ GN         F ID  +G + L   L H  
Sbjct: 2716 VPIGTEIDLIRAEHS-----GTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHET 2770

Query: 839  STTLSLMVSA---QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI 895
            +      + A   QD   + A +  DV+I +         FE   Y   + E++P  S +
Sbjct: 2771 TKWYQFSILARCTQDDHEMVASV--DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRV 2828

Query: 896  GTVKAREPLNSSE-PIFYRIS---SGDLGGKFSIHPRLGTIRTRKPLDHETQP-VVVLTV 950
              ++A +  + +   + Y +    S ++   F+I+   G I T K LDHE +    +  V
Sbjct: 2829 IQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVV 2888

Query: 951  QAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
             +  G     SST  V++TV DVND+ P F     +  +S+  P G  + +    D DS 
Sbjct: 2889 ASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSE 2948

Query: 1010 R-NGLIRYSIASPQP-GVFAIDRALGV--LFLNGSLGAGEQRELTLTLRAEDQGVHPQAA 1065
              N  + Y I    P G FA++       +++   L   ++    LT+ A D     +A 
Sbjct: 2949 EINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKA- 3007

Query: 1066 LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE 1125
             +V   V++  ++SP    E  +Y   + E + P   ++Q  A      R+ + + Y+L 
Sbjct: 3008 -IVEVKVLDANDNSP--VCEKTLYSDTIPEDVLPGKLIMQISATD-ADIRSNAEITYTLL 3063

Query: 1126 PSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEN 1185
             S  +  F + P TG +      D E    Y+  V A    DG  +    ++++ + D N
Sbjct: 3064 GS-GAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRA---TDGGGRFCQASIVLTLEDVN 3119

Query: 1186 DNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNT 1243
            DN+P F  D   + V E+  P  ++ ++ A D D+G N ++LY L+  +DG+F  +N  +
Sbjct: 3120 DNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQF-SINELS 3178

Query: 1244 GELINWVALDREHRGHHEMTVLVTDRGSPPR-NATMAVYVSVTDINDNRPFFPQCLPGKE 1302
            G +     LDRE +  + +++   D+G P R  AT  V VSV DINDN P F      +E
Sbjct: 3179 GIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEY----RE 3234

Query: 1303 LHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
                V E   V   V  V+A   D   NAE+TYS+ S
Sbjct: 3235 YGATVSEDILVGTEVLQVYAASRDIEANAEITYSIIS 3271



 Score =  279 bits (714), Expect = 1e-74
 Identities = 319/1134 (28%), Positives = 488/1134 (43%), Gaps = 108/1134 (9%)

Query: 255  DREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAE 314
            DRE+  A  + +E  +  +P     + V++ V D+NDN PVF    Y A V+ D + G  
Sbjct: 2040 DREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHV 2099

Query: 315  VCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDRE 374
            +  V A DRD G NG V Y ++           G LG+ +     EL         L++E
Sbjct: 2100 IRYVTAVDRDSGRNGEVHYYLKEHH---EHFQIGPLGEISLKKQFELD-------TLNKE 2149

Query: 375  AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGD 434
                + + V A+DGG     A V V I V+  N   P     F +    A ++E  +   
Sbjct: 2150 ----YLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYS----AEIAESIQVHS 2199

Query: 435  YVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVE 494
             V  V  +  +G                    +  S+  G+           GV  + V 
Sbjct: 2200 PVVHVQANSPEGL------------------KVFYSITDGDPFSQFTINFNTGV--INVI 2239

Query: 495  GPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAP 554
             PLD E+   Y+L + ATD+ +     E  + + V D+ND PP+F+QQ Y  ++SEA+  
Sbjct: 2240 APLDFEAHPAYKLSIRATDSLTGA-HAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298

Query: 555  GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA 614
            GT V+ V A+D+D                S P N G       + ++    F +DS +G 
Sbjct: 2299 GTSVVQVRATDSD----------------SEP-NRGISYQMFGNHSKSHDHFHVDSSTGL 2341

Query: 615  ISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAE 674
            IS +RTLD E      + V A D G P LS+  +V++ V D+NDN P+F +Q+Y A I+E
Sbjct: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401

Query: 675  HAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER 734
            HAP GH    V A DADS     ++YS+    LS    + F ID   G I +S ++ R  
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSI----LSGNDHKHFVIDSATGIITLS-NLHRHA 2456

Query: 735  DPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL 794
                Y L +   DG   S+   V V +   N + P F  + Y   +++     T ++ V 
Sbjct: 2457 LKPFYSLNLSVSDGVFRSSTQ-VHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVK 2515

Query: 795  ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL-TLPLSHLESTTLSLMVSAQDGGG 853
             TD DSGIYG V Y ++       F I+    I  L  L         +S+ + A+D GG
Sbjct: 2516 TTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGG 2575

Query: 854  LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFY 912
              A    +V I       AP +F   KY   +     + + +  V A +    S+  I Y
Sbjct: 2576 KVAFCTVNV-ILTDDNDNAP-QFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITY 2633

Query: 913  RI--SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITV 969
             I   S  +     I+   G I T++ L           V+A    +P+  S   V + +
Sbjct: 2634 AIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKI 2693

Query: 970  MDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA------SPQP 1023
            +      P F        +S+  P GT + L RAE      +G + YS+       S + 
Sbjct: 2694 LPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLYSLVKGNTPESNRD 2748

Query: 1024 GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAE-DQGVHPQAALLVLTV-VIEKREHSPS 1081
              F IDR  G L L  SL     +    ++ A   Q  H   A + +++ V +  ++SP 
Sbjct: 2749 ESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSP- 2807

Query: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM---FGIRPY 1138
              FE   Y+  + E+L   ++++Q +A           + YSL+ S    +   F I   
Sbjct: 2808 -VFESSPYEAFIVENLPGGSRVIQIRASD-ADSGTNGQVMYSLDQSQSVEVIESFAINME 2865

Query: 1139 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI--VRVWDENDNSPTFLHDVL 1196
            TGWI   ++ D+E    Y  +V A   + G    +S+T I  V V D ND+ P F  ++ 
Sbjct: 2866 TGWITTLKELDHEKRDNYQIKVVA--SDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIY 2923

Query: 1197 FLKVEESPVPQGVIGKITAIDMDSGK-NGQLLYFLLSD---GKF-FKMNPNTGELINWVA 1251
               V E     GVI  ++  D DS + N Q+ YF+      G+F  +   N  ++     
Sbjct: 2924 KGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKP 2983

Query: 1252 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311
            LDRE R ++ +T+  TD      ++   V V V D NDN P   + L    +   VL G+
Sbjct: 2984 LDREKRDNYLLTITATD---GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGK 3040

Query: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV--SSARPMPLKGKTAFGKQSCKKQTNKQ 1363
                L+  + A D D  +NAE+TY++  S A    L   T   K S      +Q
Sbjct: 3041 ----LIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQ 3090



 Score =  277 bits (708), Expect = 6e-74
 Identities = 302/1132 (26%), Positives = 489/1132 (43%), Gaps = 154/1132 (13%)

Query: 282  VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
            V ++VLD ND  P+F    Y  ++ E+      + RV ATD D+G NG   YS + R   
Sbjct: 135  VRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDR--- 191

Query: 342  GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSI 401
                          FA+   SGV+ +   LD      +++ + A D G +   ++   S+
Sbjct: 192  -----------TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSM 240

Query: 402  AVLDV-----NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
            A L V     N+  P I  + L+       SE  R   Y A V+V D D        A G
Sbjct: 241  AKLTVHIEQANECAPVITAVTLSP------SELDRDPAY-AIVTVDDCD------QGANG 287

Query: 457  ELGVGLGDGSISLSLEGGE--GDFALLPGGPPG-VFFLCVEGPLDRESRDL-YELLLVAT 512
            ++         SLS+  G+    F  +   P    + +   G +D +S    Y L L A 
Sbjct: 288  DIA--------SLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAK 339

Query: 513  DAGSPP-LSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGS 571
            D G+PP  S+ + + +        P  F +  Y+A +SE A P T V+ V A  A     
Sbjct: 340  DKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----- 394

Query: 572  DHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVEL 631
             ++ LRY  V  S P                   F+++  +G IS +  + R+     EL
Sbjct: 395  -YSHLRY--VFKSTPGK---------------AKFSLNYNTGLISILEPVKRQQAAHFEL 436

Query: 632  KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
            +V   D       A+  V + V   N N P F +  Y A   E+ P+G   + ++A D D
Sbjct: 437  EVTTSD-----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD 491

Query: 692  SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-- 749
             G  G++ YS+ +  L++     F ID   G +  S+++D E  P  Y L + A D G  
Sbjct: 492  EGENGYVTYSIAN--LNH---VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546

Query: 750  -GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808
                 +    + L ++NDN P+F       +I  +   G +I  V A D D      V Y
Sbjct: 547  YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQY 604

Query: 809  ELIPGNVSSLFTIDSTTGIIYLTLPLSH---LESTTLSLMVSAQDGGGLTAVINADVTI- 864
            ++  GN    F+++  +G++ L   L      + +  SL ++A DG      +  ++T+ 
Sbjct: 605  QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664

Query: 865  --------HIFQTTLAPAEFERPKYTFLVY-----EDVPEDS--------------PIG- 896
                       +T +A    E+      ++     ED+  DS              P G 
Sbjct: 665  ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724

Query: 897  TVKAREPLNSS--------------EPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
             VK  +P+ SS                + Y +S G+    F I    G ++   PLD ET
Sbjct: 725  QVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET 784

Query: 943  QPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
                 L +    LG     +   +++ V+D NDN P FL+ S  + +S+     + +   
Sbjct: 785  TDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQV 844

Query: 1002 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-V 1060
             A D+D G NG + YSI +     F+ID   GV+ +   L    Q E +L + A DQ   
Sbjct: 845  EATDKDLGPNGHVTYSIVT-DTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903

Query: 1061 HPQA-ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--PLGPQRAA 1117
             PQ  + +V+ V +E    +P  TF    Y+V+V E L   T ++  +AH   LG    +
Sbjct: 904  EPQLFSTVVVKVSLEDVNDNPP-TFIPPNYRVKVREDLPEGTVIMWLEAHDPDLG---QS 959

Query: 1118 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 1176
              +RYSL        F +   +G + + +Q D+E  Q YN  V A   + G   ++S+T 
Sbjct: 960  GQVRYSLLDH-GEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA--KDKGKPVSLSSTC 1016

Query: 1177 -VIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
             V V V D N+N   P F   V    V+E      ++  ++A D D+ ++G++ Y  + D
Sbjct: 1017 YVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRY-SIRD 1075

Query: 1234 GK---FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
            G     FK+   TG +     LDRE   H+ +TV  TD+G  P ++ + +Y+ V D+NDN
Sbjct: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135

Query: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
             P   + +     + +++E  P ++ V  + A DPD  +N ++ Y ++S  P
Sbjct: 1136 APQTSEPV----YYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNP 1183



 Score =  275 bits (704), Expect = 2e-73
 Identities = 326/1299 (25%), Positives = 535/1299 (41%), Gaps = 162/1299 (12%)

Query: 77   LPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPL-LDDFHVHPDTGIIRTARRLDRER 135
            +P DT        + A  Q E +    +  S   PL L  F + P TG + T+ +LD E 
Sbjct: 1465 IPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEA 1524

Query: 136  RDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLP 189
               ++         V       ++ + V+D NDH+P F   S +  V E +  G+     
Sbjct: 1525 VHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQV 1584

Query: 190  VAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL--D 247
             A D D G  +   Y++   +                           G+S  ++P+   
Sbjct: 1585 TALDKDKGKNAEVLYSIESGNI--------------------------GNSFMIDPVLGS 1618

Query: 248  LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
            +   + LDR   A + L ++A D G P  + + SV + V   ++  P F   EY   + E
Sbjct: 1619 IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSE 1678

Query: 308  DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
                G+ V  V A  +       V Y ++           G  GDA  F +   SG +  
Sbjct: 1679 TVSIGSFVGMVTAHSQSS-----VVYEIK----------DGNTGDA--FDINPHSGTIIT 1721

Query: 368  WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
             + LD E    + L+++  +        TV V +   D NDN P    +F+       +S
Sbjct: 1722 QKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQ--DENDNAP----VFMQAEYTGLIS 1775

Query: 428  EGARPGDYVAR-------VSVSDADGDWEK-------EDEATGELGVGLGDGSISLSLEG 473
            E A     V         +  +DAD D          E        +    G+I   L  
Sbjct: 1776 ESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS- 1834

Query: 474  GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE--ETLLLRVAD 531
                                   LD E   ++   +   D G+P L  E    + + V D
Sbjct: 1835 -----------------------LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVID 1871

Query: 532  LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
            +ND PP+F++  Y+AS+      G  V+ V+A+DAD   S  + L Y++ +         
Sbjct: 1872 INDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADS--SAFSQLIYSITE--------- 1920

Query: 592  LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
                       G  F++D ++GA++   T   +++   EL V A D     L++   V I
Sbjct: 1921 --------GNIGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASDGRFAGLTS---VKI 1967

Query: 652  TVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
             V +  ++   F + VY+A + E++        +TA      +   I   L+   L+ + 
Sbjct: 1968 NVKESKESHLKFTQDVYSAVVKENSTEAETLAVITA------IGNPINEPLFYHILNPD- 2020

Query: 712  PQAFRIDPHDGQICVS-QDIDRERDPATYDLLVEAKDGGGLSAQAFV--RVDLEDVNDNH 768
             + F+I    G +  +    DRE+  A +D++VE  +    SA A V  +V +ED NDN 
Sbjct: 2021 -RRFKISRTSGVLSTTGTPFDREQQEA-FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNA 2078

Query: 769  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN----VSSLFTIDST 824
            PVF    Y   +  +T+ G  I  V A D+DSG  G V Y L   +    +  L  I   
Sbjct: 2079 PVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLK 2138

Query: 825  TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
                  TL   +L      + V A+DGG      +A+V + I     A   FE+P Y+  
Sbjct: 2139 KQFELDTLNKEYL------VTVVAKDGGN--PAFSAEVIVPITVMNKAMPVFEKPFYSAE 2190

Query: 885  VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
            + E +   SP+  V+A  P      +FY I+ GD   +F+I+   G I    PLD E  P
Sbjct: 2191 IAESIQVHSPVVHVQANSP--EGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHP 2248

Query: 945  VVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
               L+++A      A +   V+I V D+NDN P F + S  + +S+ +  GT++   RA 
Sbjct: 2249 AYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRAT 2308

Query: 1005 DRDSGRNGLIRYSI---ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
            D DS  N  I Y +    S     F +D + G++ L  +L   + R+ T+ +RA D G+ 
Sbjct: 2309 DSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP 2368

Query: 1062 PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 1121
              ++ +++TV +     +P   FE  +Y+  +SE  +P    +               L+
Sbjct: 2369 TLSSDVIVTVDVTDLNDNPP-LFEQQIYEARISEH-APHGHFVTCVKAYDADSSDIDKLQ 2426

Query: 1122 YSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV 1181
            YS+    D   F I   TG I L     +     Y+  +      DG  ++ ST V V V
Sbjct: 2427 YSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSV---SDGVFRS-STQVHVTV 2482

Query: 1182 WDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP 1241
               N +SP FL +   +++ E+     ++ ++   D DSG  G + Y +++D    +   
Sbjct: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542

Query: 1242 N-TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
            N  G++     LDRE      ++V +  + +  + A   V V +TD NDN P F      
Sbjct: 2543 NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQF----RA 2598

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
             +  V +         V  V A D DEG+NA++TY++ +
Sbjct: 2599 TKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA 2637



 Score =  267 bits (683), Expect = 5e-71
 Identities = 329/1256 (26%), Positives = 538/1256 (42%), Gaps = 160/1256 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA---VVQVEIRVNDVNDHSPRFPLDSL 172
            F V   TG I  A+ LD E++ +Y+       G    + QV I+V D NDH P+F     
Sbjct: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKY 1461

Query: 173  QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
            ++ + E + P T      A D D    +   YTL    D       P    ++R      
Sbjct: 1462 EVVIPEDTAPETEILQISAVDQDEK--NKLIYTLQSSRD-------PLSLKKFR------ 1506

Query: 233  SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
              L P + S      L    +LD E    H L +   D   P +     + + V D ND+
Sbjct: 1507 --LDPATGS------LYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDH 1558

Query: 293  PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
             P F    Y+  V E A  G+ V +V A D+D G N  V YS+ +          G +G+
Sbjct: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES----------GNIGN 1608

Query: 353  AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP--EVATVRVSIAVLDVNDNR 410
            +  F ++ + G ++  + LDR  QA + L+V+A D G+ P  E+ +VR+ + + D    +
Sbjct: 1609 S--FMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666

Query: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSV-SDADGDWEKEDEATGELGVGLGDGSISL 469
                  F ++     +SE    G +V  V+  S +   +E +D  TG+        +  +
Sbjct: 1667 ------FTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGD--------AFDI 1712

Query: 470  SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRV 529
            +   G                +  +  LD E+  +Y L++  T+     LST  T+L+ +
Sbjct: 1713 NPHSGT---------------IITQKALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHL 1755

Query: 530  ADLNDQPPLFSQQHYKASVSEAAAPGTVVMW-------VSASDADEAGSDHAWLRYTVVQ 582
             D ND  P+F Q  Y   +SE+A+  +VV+        + A+DAD+    +A L Y +V+
Sbjct: 1756 QDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK--DSNALLVYHIVE 1813

Query: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
             S            VHT      FAIDS +GAI T+ +LD E        V   D+G P 
Sbjct: 1814 PS------------VHTY-----FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856

Query: 643  LSATCLVSITVD--DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
            L A    ++TV   D+ND  P+F + +Y A++      G   + V A+DADS  +  + Y
Sbjct: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIY 1916

Query: 701  SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFVR 758
            S+ +G +     + F +D   G + V          + Y+L V A DG   GL++   V+
Sbjct: 1917 SITEGNIG----EKFSMDYKTGALTVQNTTQLR---SRYELTVRASDGRFAGLTS---VK 1966

Query: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
            +++++  ++H  F    Y +++  E     E + V+ T   + I   + Y ++  N    
Sbjct: 1967 INVKESKESHLKFTQDVY-SAVVKENSTEAETLAVI-TAIGNPINEPLFYHIL--NPDRR 2022

Query: 819  FTIDSTTGIIYLT-LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI-FQTTLAPAEF 876
            F I  T+G++  T  P    +     ++V   +    +AV +  V + +  Q   AP   
Sbjct: 2023 FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFV 2082

Query: 877  ERPKYTFLVYEDVPEDSPIG------TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
              P Y       V  D+ +G      T   R+   + E  +Y     +    F I P LG
Sbjct: 2083 NLPYYAV-----VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE---HFQIGP-LG 2133

Query: 931  TIRTRKPLDHET-QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 989
             I  +K  + +T     ++TV A+ G  PA S+ EV + +  +N   P F +      I+
Sbjct: 2134 EISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA-EVIVPITVMNKAMPVFEKPFYSAEIA 2192

Query: 990  QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRE 1048
            ++    + +   +A   +  +   + YSI    P   F I+   GV+ +   L       
Sbjct: 2193 ESIQVHSPVVHVQANSPEGLK---VFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPA 2249

Query: 1049 LTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
              L++RA D      A + V  +V +  ++ P   F    Y V +SE+    T ++Q +A
Sbjct: 2250 YKLSIRATDSLTGAHAEVFVDIIVDDINDNPP--VFAQQSYAVTLSEASVIGTSVVQVRA 2307

Query: 1109 --HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
                  P R  S   +    S     F +   TG I L R  DYE ++ +   V A    
Sbjct: 2308 TDSDSEPNRGISYQMFG-NHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRA---V 2363

Query: 1167 DGFLQNVSTTVIVR--VWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
            DG +  +S+ VIV   V D NDN P F   +   ++ E       +  + A D DS    
Sbjct: 2364 DGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDID 2423

Query: 1225 QLLYFLLS--DGKFFKMNPNTGELINWVALDREH-RGHHEMTVLVTDRGSPPRNATMAVY 1281
            +L Y +LS  D K F ++  TG +I    L R   +  + + + V+D     R++T  V+
Sbjct: 2424 KLQYSILSGNDHKHFVIDSATG-IITLSNLHRHALKPFYSLNLSVSD--GVFRSSTQ-VH 2479

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            V+V   N + P F Q     E  V++ E  P++ LV  V   D D G    VTY +
Sbjct: 2480 VTVIGGNLHSPAFLQ----NEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHI 2531



 Score =  265 bits (678), Expect = 2e-70
 Identities = 326/1231 (26%), Positives = 495/1231 (40%), Gaps = 143/1231 (11%)

Query: 166  RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
            +F  D  + ++SE +PP T    PV        +S   Y           P    F L Y
Sbjct: 366  KFEKDVYRAEISEFAPPNT----PVVMVKAIPAYSHLRYVF------KSTPGKAKFSLNY 415

Query: 226  RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
             T          G  S LEP+         R++AA   L++   D     R     V ++
Sbjct: 416  NT----------GLISILEPVK--------RQQAAHFELEVTTSD-----RKASTKVLVK 452

Query: 286  VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV-RARQVPGAG 344
            VL  N NPP F Q  Y+AA  E+   G  V  + A D D G NG+V YS+     VP   
Sbjct: 453  VLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--- 509

Query: 345  SGGGALGDAAYFAVEELSGVVRVWRPLDREAQAW-HQLVVEARDGGAE-PEVATVRVSIA 402
                       FA++  +G V     LD E     + L + A D G        V  +I 
Sbjct: 510  -----------FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT 558

Query: 403  VLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDW--EKEDEATGELGV 460
            + ++NDN P    +   EG + R       G+ +  VS  DAD     + + EA  EL  
Sbjct: 559  LNNLNDNTPLFEKINC-EGTIPR---DLGVGEQITTVSAIDADELQLVQYQIEAGNELDF 614

Query: 461  -GLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
              L   S  LSL+    D          +     +G  +  +  LY  + VA       L
Sbjct: 615  FSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLYINITVAASHKLVNL 672

Query: 520  STEET--------LLLRVADLNDQPPL----FSQQHYKASVSEAAAPGTVVMWVSASDAD 567
              EET         LL+   L++Q  +    F      A + +  +  T+   +   +  
Sbjct: 673  QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRS--TLPTGIQVKENQ 730

Query: 568  EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDRE 624
              GS   ++  T +             K+V+    G     F ID E+G +  +  LDRE
Sbjct: 731  PVGSSVIFMNSTDLDTG-------FNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRE 783

Query: 625  VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQ 684
              +   L +   DLG P  +A  L+ + V D NDN P F ++ Y   ++E   V    +Q
Sbjct: 784  TTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQ 843

Query: 685  VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 744
            V A+D D G  G + YS+            F ID   G + +++ +DRE     + L +E
Sbjct: 844  VEATDKDLGPNGHVTYSIVTD------TDTFSIDSVTGVVNIARPLDRELQ-HEHSLKIE 896

Query: 745  AKDGGGLSAQAF----VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDS 800
            A+D      Q F    V+V LEDVNDN P F P  Y   + ++   GT I+ + A D D 
Sbjct: 897  ARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL 956

Query: 801  GIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAV 857
            G  G V Y L+     + F +D  +G + +   L   +    +L V A+D G    L++ 
Sbjct: 957  GQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSST 1015

Query: 858  INADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISS 916
               +V +      L P  F        V ED P  S + TV A  E       I Y I  
Sbjct: 1016 CYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD 1075

Query: 917  GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 975
            G   G F I    G I T   LD E+     LTV A   G  P  S  E+ I V DVNDN
Sbjct: 1076 GSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDN 1135

Query: 976  HPAFLRTSDEI---RISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 1031
             P   +TS+ +    I + +P   ++    A D DS  N  + Y I S  P G F+I   
Sbjct: 1136 AP---QTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPK 1192

Query: 1032 LGVLFLNG-SLGAGEQRELTLTLRAEDQGVHPQAALL-VLTVVIEKREHSPSWTFEHLVY 1089
             G++      L   +Q E  L +   D G  P++ +  V+  ++++ ++ P   F    Y
Sbjct: 1193 TGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQ--FLQKFY 1250

Query: 1090 QVEVSESLSP---MTQMLQTQAHPLGPQRAASP---LRYSLEPSVDSAMFGIRPYTGWIY 1143
            ++ + E   P        +   H +   +   P   + YS+E   +   F I P TG + 
Sbjct: 1251 KIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVS 1310

Query: 1144 LRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSP----TFLHDVLFLK 1199
             +R   + +   Y+      + ++G  Q  STT +   W           +F        
Sbjct: 1311 SKR---FSAAGEYDILSIKAV-DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFT 1366

Query: 1200 VEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGELINWVALDREH 1256
            V ES     +IG I+         G  L+F ++ G +   F ++  TG +I    LD E 
Sbjct: 1367 VMESDPVAHMIGVISV-----EPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQ 1421

Query: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
            + ++ +TV  TD  +        V++ V D ND+RP F       +  V + E       
Sbjct: 1422 KSNYNLTVEATDGTT---TILTQVFIKVIDTNDHRPQFST----SKYEVVIPEDTAPETE 1474

Query: 1317 VTTVFAKDPDEGNNAEVTYSVSSAR-PMPLK 1346
            +  + A D DE N  ++ Y++ S+R P+ LK
Sbjct: 1475 ILQISAVDQDEKN--KLIYTLQSSRDPLSLK 1503



 Score =  239 bits (610), Expect = 1e-62
 Identities = 318/1264 (25%), Positives = 524/1264 (41%), Gaps = 155/1264 (12%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL----LGAVVQVEIRVNDVNDHSPRFPL 169
            D F ++P +G I T + LD E    Y+ +        L     V + + D ND++P F  
Sbjct: 1708 DAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVF-- 1765

Query: 170  DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
              +Q + + L     +    V  D +  L       +++ +D  KD       L Y    
Sbjct: 1766 --MQAEYTGLISESASINSVVLTDRNVPL-------VIRAADADKDSNA---LLVYHIVE 1813

Query: 230  PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG--LLSVELRVL 287
            P         SS    +  VL   LD EE +     ++  D G PR       +V + V+
Sbjct: 1814 PSVHTYFAIDSST-GAIHTVL--SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870

Query: 288  DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
            D ND PPVF +  Y A++      G +V  V ATD D      + YS+            
Sbjct: 1871 DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE---------- 1920

Query: 348  GALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
            G +G+   F+++  +G + V       ++  ++L V A DG          V I V +  
Sbjct: 1921 GNIGEK--FSMDYKTGALTVQNTTQLRSR--YELTVRASDGRF---AGLTSVKINVKESK 1973

Query: 408  DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
            ++    H+ F  +   A V E +   + +A ++   A G+   E      L     D   
Sbjct: 1974 ES----HLKFTQDVYSAVVKENSTEAETLAVIT---AIGNPINEPLFYHILNP---DRRF 2023

Query: 468  SLSLEGGEGDFALLPGGPPGVFFLCVEG-PLDRESRDLYELLLVATDAGSPPLSTEETLL 526
             +S   G                L   G P DRE ++ +++++  T+   P       + 
Sbjct: 2024 KISRTSG---------------VLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVK 2068

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEA--GSDHAWLR--YTVVQ 582
            + V D ND  P+F    Y A V      G V+ +V+A D D    G  H +L+  +   Q
Sbjct: 2069 VIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQ 2128

Query: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
            +     LG +  K          F +D          TL++E      + VVA+D G P 
Sbjct: 2129 IGP---LGEISLK--------KQFELD----------TLNKEYL----VTVVAKDGGNPA 2163

Query: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAE----HAPVGHCFLQVTASDADSGLYGFI 698
             SA  +V ITV  +N   P+F +  Y+A IAE    H+PV H       +++  GL  F 
Sbjct: 2164 FSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPVVH-----VQANSPEGLKVF- 2215

Query: 699  EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG-GGLSAQAFV 757
             YS+ DG    +    F I+ + G I V   +D E  PA Y L + A D   G  A+ FV
Sbjct: 2216 -YSITDG----DPFSQFTINFNTGVINVIAPLDFEAHPA-YKLSIRATDSLTGAHAEVFV 2269

Query: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
             + ++D+NDN PVF   +Y  ++S+ +  GT ++ V ATD DS     ++Y++   +  S
Sbjct: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329

Query: 818  --LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
               F +DS+TG+I L   L + +S   ++ V A DGG  T   +  VT+ +      P  
Sbjct: 2330 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPL 2389

Query: 876  FERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTIRT 934
            FE+  Y   + E  P    +  VKA +  +S  + + Y I SG+    F I    G I  
Sbjct: 2390 FEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITL 2449

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
                 H  +P   L +    G     SST+V++TV+  N + PAFL+   E+ +++  P 
Sbjct: 2450 SNLHRHALKPFYSLNLSVSDGVFR--SSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPL 2507

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDR----ALGVLFLNGSLGAGEQRELT 1050
             T +   +  D DSG  G + Y I +     FA DR      G +F    L      E  
Sbjct: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVND----FAKDRFYINERGQIFTLEKLDRETPAEKV 2563

Query: 1051 LTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
            +++R   +    + A   + V++ +  +++P   F    Y+V +  S +  T +++  A 
Sbjct: 2564 ISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQ--FRATKYEVNIGSSAAKGTSVVKVLAS 2621

Query: 1110 PLGPQRAASPLRYSLEPSVDSAM--FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167
                + + + + Y++E   +S      I   +G I  +        + + F  F    ++
Sbjct: 2622 D-ADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF--FVRAVDN 2678

Query: 1168 GFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGK-NGQ 1225
            G     S  ++ V++       P F        V E  VP G     T ID+   + +G 
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSED-VPIG-----TEIDLIRAEHSGT 2732

Query: 1226 LLYFLLSDG-------KFFKMNPNTGELINWVALDREHRGHHEMTVLV-TDRGSPPRNAT 1277
            +LY L+          + F ++  +G L    +LD E    ++ ++L    +      A+
Sbjct: 2733 VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVAS 2792

Query: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            + V + V D NDN P F            ++E  P    V  + A D D G N +V YS+
Sbjct: 2793 VDVSIQVKDANDNSPVF----ESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL 2848

Query: 1338 SSAR 1341
              ++
Sbjct: 2849 DQSQ 2852



 Score =  187 bits (475), Expect = 6e-47
 Identities = 267/1057 (25%), Positives = 429/1057 (40%), Gaps = 142/1057 (13%)

Query: 350  LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
            LGD  +  +    G   +   L+RE +  + L+V+A +     E  T +V + VLD ND 
Sbjct: 90   LGDFCFLRIRTKGGNTAI---LNREVKDHYTLIVKALEKNTNVEART-KVRVQVLDTNDL 145

Query: 410  RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
            RP    LF        + E       +ARVS +DAD            +G    +G    
Sbjct: 146  RP----LFSPTSYSVSLPENTAIRTSIARVSATDAD------------IGT---NGEFYY 186

Query: 470  SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA-----GSPPLSTEET 524
            S +     FA+ P    GV  L   G LD     LYE+ ++A D      GS  +S+   
Sbjct: 187  SFKDRTDMFAIHP--TSGVIVL--TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAK 242

Query: 525  LLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
            L + +   N+                  AP    + +S S+ D    D A+   TV    
Sbjct: 243  LTVHIEQANE-----------------CAPVITAVTLSPSELDR---DPAYAIVTVDDCD 282

Query: 585  APCNLGSLQSKMVHTAECGPSFAI-----DSESGAISTIRTLDREVQE-AVELKVVAQDL 638
               N G + S  +   +    F        S+   +  I  +D +       L + A+D 
Sbjct: 283  QGAN-GDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK 341

Query: 639  GEPP-LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGF 697
            G PP  S+  ++ +T          F + VY A I+E AP     + V A  A    Y  
Sbjct: 342  GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSH 397

Query: 698  IEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFV 757
            + Y     F S      F ++ + G I + + + R++  A ++L V   D     A   V
Sbjct: 398  LRYV----FKSTPGKAKFSLNYNTGLISILEPVKRQQ-AAHFELEVTTSD---RKASTKV 449

Query: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
             V +   N N P F  + Y  +  +    GT ++++ A D D G  G V Y +   N++ 
Sbjct: 450  LVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI--ANLNH 507

Query: 818  L-FTIDSTTGIIYLTLPLSH-LESTTLSLMVSAQDGG-GLTAVINADVTIHIFQTTLAPA 874
            + F ID  TG +  +  L + L     +L + A D G      +    TI +        
Sbjct: 508  VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTP 567

Query: 875  EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
             FE+      +  D+     I TV A +  +  + + Y+I +G+    FS++P  G +  
Sbjct: 568  LFEKINCEGTIPRDLGVGEQITTVSAID-ADELQLVQYQIEAGNELDFFSLNPNSGVLSL 626

Query: 935  RKPL---------------------DHETQPVVVLTVQAQ-------------------- 953
            ++ L                     +  T   + +TV A                     
Sbjct: 627  KRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEK 686

Query: 954  -LGSAPACSSTEVNITVMD---VNDNHPAFLRT-SDEIRISQTTPPGTALYLARAEDRDS 1008
             L +    +  EV     D   VN + P F  T    I++ +  P G+++    + D D+
Sbjct: 687  LLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT 746

Query: 1009 GRNGLIRYSIA-SPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 1067
            G NG + Y+++   +   F ID   G+L +   L      + TL +   D G+  +AA  
Sbjct: 747  GFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806

Query: 1068 VL-TVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSL 1124
            +L  VV++  ++ P +  E   Y VEVSE     ++++Q +A    LGP      + YS+
Sbjct: 807  LLHVVVVDANDNPPEFLQES--YFVEVSEDKEVHSEIIQVEATDKDLGPN---GHVTYSI 861

Query: 1125 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWD 1183
                D+  F I   TG + + R  D E    ++ ++ A        Q  ST V+ V + D
Sbjct: 862  VTDTDT--FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLED 919

Query: 1184 ENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGK-FFKMNP 1241
             NDN PTF+     +KV E  +P+G VI  + A D D G++GQ+ Y LL  G+  F ++ 
Sbjct: 920  VNDNPPTFIPPNYRVKVRED-LPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978

Query: 1242 NTGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTDINDNRPFFPQCLPG 1300
             +G +     LD E +  + +TV   D+G P   ++T  V V V D+N+N    P     
Sbjct: 979  LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNEN--LHPPVFSS 1036

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
                  V E  PV  LV TV A D D   + E+ YS+
Sbjct: 1037 FVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI 1073



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 133/578 (23%), Positives = 222/578 (38%), Gaps = 90/578 (15%)

Query: 801  GIYGT-----VAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLT 855
            G+Y T     V Y+++ G+  +LF  +      Y+      L   T          GG T
Sbjct: 60   GVYITHPAWEVRYKIVSGDSENLFKAEE-----YILGDFCFLRIRTK---------GGNT 105

Query: 856  AVINADVTIH-------IFQTTLAPAEFE-----------RPKYTFLVYE-DVPEDSPIG 896
            A++N +V  H       + + T   A  +           RP ++   Y   +PE++ I 
Sbjct: 106  AILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165

Query: 897  TVKAR-----EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
            T  AR       + ++   +Y  S  D    F+IHP  G I     LD+    +  + + 
Sbjct: 166  TSIARVSATDADIGTNGEFYY--SFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEIL 223

Query: 952  AQ------LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAED 1005
            A        GS+   S  ++ + +   N+  P     +         P   A  +   +D
Sbjct: 224  AADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDD 280

Query: 1006 RDSGRNG------------LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             D G NG            L ++      PG     +   V  + G           LTL
Sbjct: 281  CDQGANGDIASLSIVAGDLLQQFRTVRSFPG----SKEYKVKAIGGIDWDSHPFGYNLTL 336

Query: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
            +A+D+G  PQ + + +  V   +  +    FE  VY+ E+SE   P T ++  +A P   
Sbjct: 337  QAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIP--- 393

Query: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
              A S LRY  + +   A F +   TG I +      +    +   V      D   +  
Sbjct: 394  --AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTT---SD---RKA 445

Query: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLS 1232
            ST V+V+V   N N P F         +E+ VP G  +  ++A+D D G+NG + Y + +
Sbjct: 446  STKVLVKVLGANSNPPEFTQTAYKAAFDEN-VPIGTTVMSLSAVDPDEGENGYVTYSIAN 504

Query: 1233 DGKF-FKMNPNTGELINWVALDREHRGH-HEMTVLVTDRGSP-PRNATMAVYVSVTDIND 1289
                 F ++  TG +     LD E     + + +  +D G P  R   +   +++ ++ND
Sbjct: 505  LNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLND 564

Query: 1290 NRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 1327
            N P F +          +     V   +TTV A D DE
Sbjct: 565  NTPLFEKI----NCEGTIPRDLGVGEQITTVSAIDADE 598



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 60/263 (22%), Positives = 100/263 (38%), Gaps = 20/263 (7%)

Query: 1084 FEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT--GW 1141
            F HL Y V V E+ +  T +       +     A  +RY +       +F    Y    +
Sbjct: 34   FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93

Query: 1142 IYLRRQFDYESTQTYN------FRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 1195
             +LR +    +T   N      + +     E        T V V+V D ND  P F    
Sbjct: 94   CFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTS 153

Query: 1196 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDRE 1255
              + + E+   +  I +++A D D G NG+  Y        F ++P +G ++    LD  
Sbjct: 154  YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYL 213

Query: 1256 HRGHHEMTVLVTDR-----GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
                +EM +L  DR     GS   ++   + V +   N+  P     +    L    L+ 
Sbjct: 214  ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAP----VITAVTLSPSELDR 269

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEV 1333
             P   +VT     D D+G N ++
Sbjct: 270  DPAYAIVT---VDDCDQGANGDI 289



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 8/115 (6%)

Query: 1229 FLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
            ++L D  F ++    G   N   L+RE + H+ + V   ++ +     T  V V V D N
Sbjct: 88   YILGDFCFLRIRTKGG---NTAILNREVKDHYTLIVKALEKNTNVEARTK-VRVQVLDTN 143

Query: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPM 1343
            D RP F          V + E   +   +  V A D D G N E  YS      M
Sbjct: 144  DLRPLFSPT----SYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDM 194


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  354 bits (908), Expect = 4e-97
 Identities = 356/1243 (28%), Positives = 531/1243 (42%), Gaps = 125/1243 (10%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRF 167
            D FH+   +G+I TAR LD E   H +    ++      L + V V I ++DVND+ P F
Sbjct: 2335 DYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVF 2394

Query: 168  PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
                 +  VSEL+P G       A D D+  F    Y+++  +D                
Sbjct: 2395 NQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDR--------------- 2439

Query: 228  PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVL 287
                 +  L  S S +  L     +R++      + L +   DG     T    V +RVL
Sbjct: 2440 -----TSFLMDSKSGVITLSNHRKQRME----PLYSLNVSVSDG---LFTSTAQVHIRVL 2487

Query: 288  DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
              N   P F Q  Y A VRE+   G +V  VRATD D G  G + Y++            
Sbjct: 2488 GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAI------------ 2535

Query: 348  GALGDAAY--FAVEELSGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAV 403
              + D A   F ++    V+   R LDRE   +    + V A DGG      TVRV   V
Sbjct: 2536 --INDFAKDRFLIDSNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRV--IV 2590

Query: 404  LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL- 462
            +D NDN P     F+T    A V      G  V +V   D D      D A   +   L 
Sbjct: 2591 VDENDNAPQ----FMTVEYRASVRADVGRGHLVTQVQAIDPD------DGANSRITYSLY 2640

Query: 463  GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
             + S+S+         A L    P   ++  +G  ++    +    + A D G P   + 
Sbjct: 2641 SEASVSV---------ADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSL 2691

Query: 523  ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
              + + V       P F+Q  Y  +++E  A G+ V  +         S + W  ++ V 
Sbjct: 2692 IPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILP-----SQNVW--FSTVN 2744

Query: 583  LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ-DLGEP 641
               P N              G  F I+ E+G I   + LDRE   A   KV A   L + 
Sbjct: 2745 GERPEN------------NKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792

Query: 642  PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
             +  T  V I V D+NDN+P+F    Y+  I E  PVG    QV A D D G  G + YS
Sbjct: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS 2852

Query: 702  LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVR 758
            L+      +  +AF ID + G I   +D+D E DP T+   V A D G    LS+ A V 
Sbjct: 2853 LHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDP-TFTFSVVASDLGEAFSLSSTALVS 2911

Query: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT-DQD-SGIYGTVAYELIPGNVS 816
            V + D+NDN PVF    Y  ++ +   PG E++ VL+T D+D S +   V+Y +  GN  
Sbjct: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPG-EVVAVLSTWDRDTSDVNRQVSYHITGGNPR 2970

Query: 817  SLFTID--STTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
              F +    +   +Y+  PL   E     L ++A DG     V  A V + +        
Sbjct: 2971 GRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSP 3027

Query: 875  EFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933
              ++  YT L+ ED+P +  I  V A++  + S+  I Y +  G    +F + P  G ++
Sbjct: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELK 3086

Query: 934  TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
            T   LD E  PV  L  +A  G    C S  +++ + DVNDN P F        + + T 
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSN-IHLILEDVNDNPPVFSSDHYNTCVYENTA 3145

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
                L   +A D D G N  + YS+A    GVF+ID + G++ L   L   +Q    +++
Sbjct: 3146 TKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISV 3205

Query: 1054 RAEDQ--GVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL 1111
            RA DQ  G    +   V   V++  ++ P   FE   Y V V E  SP TQ+L   A   
Sbjct: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPP--VFERRDYLVTVPEDTSPGTQVLAVFATSK 3263

Query: 1112 GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
                 A  + Y +    +   F I P TG I +    DYE  + +   V A   +DG   
Sbjct: 3264 DIGTNAE-ITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEA---KDGGTP 3319

Query: 1172 NVST--TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 1229
             +S   TV + + D NDN P F  DV    + E  +    +  + A D+DS  NGQ+ + 
Sbjct: 3320 ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFS 3379

Query: 1230 LLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 1287
            +++  +   F ++P  G +     LDRE    + + V   D G P  ++T  V + ++D+
Sbjct: 3380 IVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439

Query: 1288 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
            NDN P F    P     V + E +PV   +  +   D D  +N
Sbjct: 3440 NDNSPVF---TPANYTAV-IQENKPVGTSILQLVVTDRDSFHN 3478



 Score =  346 bits (888), Expect = 8e-95
 Identities = 352/1270 (27%), Positives = 546/1270 (42%), Gaps = 143/1270 (11%)

Query: 101  FFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VE 154
            F +S+ + DS     F++  +TG ++    +DRE  D Y   +    LG   +     + 
Sbjct: 763  FTISDGNTDSC----FNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818

Query: 155  IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
            I V D ND+SP F  DS  +++ E S  GT      A D D G      Y+++  +    
Sbjct: 819  INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ--- 875

Query: 215  DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
                                    SS+ +    + +  +LDRE  A + L+IEA D    
Sbjct: 876  -------------------QFAINSSTGI----VYVADQLDRESKANYSLKIEARDKAES 912

Query: 275  RRTGLLSVELRVL--DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVR 332
             +     V L+V   D ND  P F    Y   V ED   G  +  +   D DLG  G VR
Sbjct: 913  GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR 972

Query: 333  YSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP 392
            YS+            G       F +++ SG +R+ + LD E Q ++ L V A+D G   
Sbjct: 973  YSL-------VNDYNGR------FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV 1019

Query: 393  EVATVR-VSIAVLDVNDNRPAIHVLFLTEGGVA-RVSEGARPGDYVARVSVSDADGDWEK 450
             +++V  V + V+DVN+N   +H  +  +  V   V E +R G  V +V+  D D   + 
Sbjct: 1020 SLSSVSFVEVEVVDVNEN---LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRD- 1075

Query: 451  EDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
                 GE+   + DGS       G G F++      GV  +     LDRE+   Y L + 
Sbjct: 1076 -----GEIQYSIRDGS-------GLGRFSI--DDESGV--ITAADILDRETMGSYWLTVY 1119

Query: 511  ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
            ATD G  PL +   + + V D+ND  PL S+  Y   V E +     V+ + A D D + 
Sbjct: 1120 ATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSS 1179

Query: 571  SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTI-RTLDREVQEAV 629
            ++    R T          G+ Q+           FAI+ ++G I+T  R LDRE Q   
Sbjct: 1180 NEKLTYRITS---------GNPQN----------FFAINIKTGLITTTSRKLDREQQAEH 1220

Query: 630  ELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEH--APVGHCFLQVTA 687
             L+V   D G  P  +T  V + V D NDN+P F  +VY   + E      G    +  A
Sbjct: 1221 FLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFA 1280

Query: 688  SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAK 746
             D D G    I YS+ DG         F IDP  G +   +         +YD+L ++A 
Sbjct: 1281 FDRDEGPNAEISYSIVDG----NDDGKFFIDPKTGMVSSRKQFTA----GSYDILTIKAV 1332

Query: 747  DGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD----ETQPGTEIINVLATDQDSGI 802
            D G     +  R+ +E +    P   P T+     +    E+   TEI+ V++    +  
Sbjct: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT- 1391

Query: 803  YGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADV 862
               + ++++ GN  S F  +   G I +  PL   + +  ++ V   DG   T V    V
Sbjct: 1392 --PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQV 1446

Query: 863  TIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG- 921
             I +        EF +P Y   + EDV  D+ I  ++A +     +  +   SS D    
Sbjct: 1447 FIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM 1506

Query: 922  -KFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAF 979
             KF I P  G + T + LDHE Q   +L +  +    P   +   V + V D ND+ P F
Sbjct: 1507 RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYF 1566

Query: 980  LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLN 1038
                 E  + ++   G+A+    A D+D G N  + Y+I +   G +F I+  LG++ + 
Sbjct: 1567 TNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITIC 1626

Query: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLS 1098
                     +  L+++  DQG  P +A  ++ + +   ++S    F H  YQ EV+E++ 
Sbjct: 1627 KEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHP-KFIHKDYQAEVNENVD 1685

Query: 1099 PMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
              T ++   A       + S L Y ++    + +F I PY+G I  ++  DYE T +Y  
Sbjct: 1686 IGTSVILISAI------SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQL 1739

Query: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK------ 1212
             + A     G   N   TV +++ DENDN+P FL       + E+     ++        
Sbjct: 1740 IIQA-TNMAGMASNA--TVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPL 1796

Query: 1213 -ITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
             I A D DS +N  L+Y ++     KFF ++ +TG +     LD E   H    V V D 
Sbjct: 1797 VIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDS 1856

Query: 1270 GSPPRNATMAVYVS--VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 1327
            GSP   A   V V+  VTD+NDN P F Q +        +L    V + V  V A DPD 
Sbjct: 1857 GSPQLTAESPVEVNIEVTDVNDNPPVFTQAV----FETILLLPTYVGVEVLKVSATDPDS 1912

Query: 1328 GNNAEVTYSV 1337
                E+TYS+
Sbjct: 1913 EVPPELTYSL 1922



 Score =  338 bits (868), Expect = 2e-92
 Identities = 356/1283 (27%), Positives = 540/1283 (42%), Gaps = 154/1283 (12%)

Query: 116  FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-VQVEIRVNDVNDHSPRFPLDSLQL 174
            F ++P +G+I TAR L+  +++ Y        G +  QV I + D NDH+P F       
Sbjct: 420  FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDA 479

Query: 175  DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
             V+E  P GT+     A D D G      Y++   + LP       F +   T       
Sbjct: 480  YVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-------FVINQFT------- 525

Query: 235  LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNP 293
               G  S  E LD              +R  + A D G P R    ++V +R+ + NDN 
Sbjct: 526  ---GVISTTEELDF-------ESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNS 575

Query: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRD-------------------LGPNGFVRYS 334
            P+FE+   +  +  D   G  +  V A D D                   L P+  V   
Sbjct: 576  PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQL 635

Query: 335  VRARQVPGAGSG----------GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQL--- 381
             ++    G  +G          G  L D     +  L G V       RE +   +L   
Sbjct: 636  KKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEK 695

Query: 382  -VVEARDGGAEPEVATVRVSIAVLD---VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
             +++A+  G       + +    LD   +N   P     F ++     V E    G  + 
Sbjct: 696  LLIKAKANGK------LNLEDGFLDFYSINRQGPYFDKSFPSD---VAVKEDLPVGANIL 746

Query: 438  RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
            ++   DAD  +  +   T  +  G  D   ++ +E G+               L V  P+
Sbjct: 747  KIKAYDADSGFNGKVLFT--ISDGNTDSCFNIDMETGQ---------------LKVLMPM 789

Query: 498  DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
            DRE  DLY L +   D G+P  S+   L + V D ND  P+F Q  Y  ++ E++  GT 
Sbjct: 790  DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849

Query: 558  VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617
            ++ V A D D                     LGS              FAI+S +G +  
Sbjct: 850  IIQVEARDKD---------------------LGSNGEVTYSVLTDTQQFAINSSTGIVYV 888

Query: 618  IRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV--DDVNDNEPIFWRQVYNATIAEH 675
               LDRE +    LK+ A+D  E       +V++ V  DDVND  P F    Y+  + E 
Sbjct: 889  ADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLED 948

Query: 676  APVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERD 735
             PVG     +   D D GL G + YSL + +        F ID   G I +S+++D E+ 
Sbjct: 949  LPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG-----RFEIDKASGAIRLSKELDYEKQ 1003

Query: 736  PATYDLLVEAKDGG---GLSAQAFVRVDLEDVNDN--HPVFNPSTYVTSISDETQPGTEI 790
               Y+L V AKD G    LS+ +FV V++ DVN+N   P F     V S+ + ++ GT +
Sbjct: 1004 QF-YNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV 1062

Query: 791  INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQD 850
            + V A D+DSG  G + Y +  G+    F+ID  +G+I     L      +  L V A D
Sbjct: 1063 LQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATD 1122

Query: 851  GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EP 909
             G +      +V I +            P Y  +V E+ P+D  +  ++A +P +SS E 
Sbjct: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEK 1182

Query: 910  IFYRISSGDLGGKFSIHPRLGTIRTR-KPLDHETQPVVVLTVQAQLGS-APACSSTEVNI 967
            + YRI+SG+    F+I+ + G I T  + LD E Q    L V    G  +P  S+  V +
Sbjct: 1183 LTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVV 1242

Query: 968  TVMDVNDNHPAFLRTSDEIRISQTTPP--GTALYLARAEDRDSGRNGLIRYSIASPQP-G 1024
             V+D NDN P F     +I++ +      G  +Y A A DRD G N  I YSI      G
Sbjct: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302

Query: 1025 VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV-IEKREHSP-SW 1082
             F ID   G++       AG      LT++A D G   +++   L +  I+K   SP   
Sbjct: 1303 KFFIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPL 1360

Query: 1083 TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
            TF+   Y   V ES   +T+++      +  Q A +PL + +      + F      G I
Sbjct: 1361 TFDEPFYNFTVMES-DRVTEIVGV----VSVQPANTPLWFDIVGGNFDSAFDAEKGVGTI 1415

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSPTFLHDVLFLKVE 1201
             + +  D E    YN  V      DG   NV+ T V ++V D NDN P F      + + 
Sbjct: 1416 VIAKPLDAEQRSIYNMSVEV---TDG--TNVAVTQVFIKVLDNNDNGPEFSQPNYDVTIS 1470

Query: 1202 ESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-----GKFFKMNPNTGELINWVALDREH 1256
            E  +P   I +I A D D  +  +L Y + S       + F+++P+TG L     LD E 
Sbjct: 1471 EDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEA 1528

Query: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
            +  H + ++V D+  P R     V V+V D ND+ P+F   L        V E   +   
Sbjct: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL----YEASVFESAALGSA 1584

Query: 1317 VTTVFAKDPDEGNNAEVTYSVSS 1339
            V  V A D D+G NAE+ Y++ +
Sbjct: 1585 VLQVTALDKDKGENAELIYTIEA 1607



 Score =  338 bits (867), Expect = 2e-92
 Identities = 335/1171 (28%), Positives = 513/1171 (43%), Gaps = 121/1171 (10%)

Query: 123  GIIRTARRLDRERR---DHYSFVAATLLGA---VVQVEIRVNDVNDHSPRFPLDSLQLDV 176
            G + T  RLDRE     D   FV A   G       V + V D ND++P+F     +  V
Sbjct: 2550 GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASV 2609

Query: 177  SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLL 236
                  G       A DPD G  S   Y+L   + +                        
Sbjct: 2610 RADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASV------------------------ 2645

Query: 237  PGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEND 291
              S + L  +D     +V     ++ +       ++A DGG P +  L+ V + VL    
Sbjct: 2646 --SVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703

Query: 292  NPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALG 351
              P F Q +Y   + ED   G+ V  +R       P+  V +S    + P    GG    
Sbjct: 2704 FLPSFTQSQYSFTIAEDTAIGSTVDTLRIL-----PSQNVWFSTVNGERPENNKGG---- 2754

Query: 352  DAAYFAVEELSGVVRVWRPLDREAQ-AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
                F +E+ +G +++ + LDRE   A+H  V           V TV V I VLD+NDN+
Sbjct: 2755 ---IFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNK 2811

Query: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI--S 468
            P    +F T      + EG   G  + +V   D D  W    + T  L        +  +
Sbjct: 2812 P----VFETSSYDTIIMEGMPVGTKLTQVRAIDMD--WGANGQVTYSLHSDSQPEKVMEA 2865

Query: 469  LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP-PLSTEETLLL 527
             +++   G  + L               LD E+   +   +VA+D G    LS+   + +
Sbjct: 2866 FNIDSNTGWISTLKD-------------LDHETDPTFTFSVVASDLGEAFSLSSTALVSV 2912

Query: 528  RVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587
            RV D+ND  P+F+Q+ Y+ +V E+  PG VV  +S  D D +  +         Q+S   
Sbjct: 2913 RVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNR--------QVSYHI 2964

Query: 588  NLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT- 646
              G+ + +         +  +      +   R LDRE Q+   L + A D     L  T 
Sbjct: 2965 TGGNPRGRF--------ALGLVQSEWKVYVKRPLDREEQDIYFLNITATD----GLFVTQ 3012

Query: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
             +V ++V DVNDN P+  +  Y A + E  P     L+V+A DAD G  G+I YSLY   
Sbjct: 3013 AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG 3072

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
             S      F +DP  G++     +DRER P  Y L+ +A DGGG   Q+ + + LEDVND
Sbjct: 3073 NS-----EFFLDPESGELKTLALLDRERIPV-YSLMAKATDGGGRFCQSNIHLILEDVND 3126

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
            N PVF+   Y T + + T     +  V A D D GI   V Y L   +   +F+IDS++G
Sbjct: 3127 NPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSSSG 3185

Query: 827  IIYLTLPLSHLESTTLSLMVSAQD---GGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
            II L  PL   + ++ ++ V A D   G  L+++    VTI +      P  FER  Y  
Sbjct: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTT--VTITVLDINDNPPVFERRDYLV 3243

Query: 884  LVYEDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
             V ED  P    +      + + ++  I Y I SG+  GKF I+P+ G I   + LD+E 
Sbjct: 3244 TVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYEL 3303

Query: 943  QPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
                 L V+A+ G  PA S+   VNI + DVNDN P F +      IS+    G ++ L 
Sbjct: 3304 CKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILL 3363

Query: 1002 RAEDRDSGRNGLIRYSIAS-PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060
             AED DS  NG I +SI +  +   F +D  LG++ +   L        +L ++A D G+
Sbjct: 3364 IAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGI 3423

Query: 1061 HPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
               ++   + + I +  ++SP +T  +  Y   + E+    T +LQ             P
Sbjct: 3424 PAMSSTATVNIDISDVNDNSPVFTPAN--YTAVIQENKPVGTSILQLVVTDRDSFHNGPP 3481

Query: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI- 1178
              +S+    +   F + P+     LR    ++ T++  + +     + G  Q VS T I 
Sbjct: 3482 FSFSILSGNEEEEFVLDPHG---ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIR 3538

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK-FF 1237
            VRV +E+ + PT +   +F+   E   P GVIGKI A D D      L + L S+ K  F
Sbjct: 3539 VRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQKSLF 3596

Query: 1238 KMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
            K+N + G++I    LD    G + + V V+D
Sbjct: 3597 KVNSHDGKIIALGGLD---SGKYVLNVSVSD 3624



 Score =  318 bits (814), Expect = 3e-86
 Identities = 331/1211 (27%), Positives = 519/1211 (42%), Gaps = 133/1211 (10%)

Query: 109  DSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAV-----VQVEIRVNDVND 162
            D   L  F +  ++G+I  A  LDRE    Y   V AT  G V     ++V I V DVND
Sbjct: 1084 DGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143

Query: 163  HSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQ 222
            ++P          V E SP   +     A DPD+   S +  T    S  P++    FF 
Sbjct: 1144 NAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSS--SNEKLTYRITSGNPQN----FFA 1197

Query: 223  LRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSV 282
            +  +T                  L     R+LDRE+ A H L++   DGG   +   + V
Sbjct: 1198 INIKT-----------------GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWV 1240

Query: 283  ELRVLDENDNPPVFEQDEYRAAV--REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340
             ++VLDENDN P F +  Y+  +  R+  + G  + R  A DRD GPN  + YS+    V
Sbjct: 1241 VVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSI----V 1296

Query: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVS 400
             G         D   F ++  +G+V   +     A ++  L ++A D G   + +T R+ 
Sbjct: 1297 DG--------NDDGKFFIDPKTGMVSSRKQF--TAGSYDILTIKAVDNGRPQKSSTARLH 1346

Query: 401  IAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV 460
            I  +      P I + F        V E  R  + V  VSV  A                
Sbjct: 1347 IEWIKKPPPSP-IPLTFDEPFYNFTVMESDRVTEIVGVVSVQPA---------------- 1389

Query: 461  GLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLS 520
               +  +   + GG  D A       GV  + +  PLD E R +Y + +  TD  +  ++
Sbjct: 1390 ---NTPLWFDIVGGNFDSAF--DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVT 1444

Query: 521  TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
                + ++V D ND  P FSQ +Y  ++SE   P T ++ + A+D DE       L YTV
Sbjct: 1445 ---QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHK----LSYTV 1497

Query: 581  VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGE 640
                   ++ S+  +          F ID  +G + T   LD E Q+   L ++ +D   
Sbjct: 1498 -----HSSIDSISMR---------KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF 1543

Query: 641  PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
            P       V + V+D ND+ P F   +Y A++ E A +G   LQVTA D D G    + Y
Sbjct: 1544 PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIY 1603

Query: 701  SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVR 758
            ++  G         F+I+P  G I + ++ D       + L ++  D G   +SA A VR
Sbjct: 1604 TIEAG----NTGNMFKIEPVLGIITICKEPDM-TTMGQFVLSIKVTDQGSPPMSATAIVR 1658

Query: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
            + +   +++HP F    Y   +++    GT +I + A  Q      T+ YE+  G+++ +
Sbjct: 1659 ISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDINGI 1713

Query: 819  FTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFER 878
            FTI+  +G+I     L +  +++  L++ A +  G+ +  NA V I I         F  
Sbjct: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS--NATVNIQIVDENDNAPVFLF 1771

Query: 879  PKYTFLVYEDVP--------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
             +Y+  + E  P        ++SP+         N +  + Y+I        F++    G
Sbjct: 1772 SQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTG 1831

Query: 931  TIRTRKPLDHETQPVVVLTVQAQLGSAP---ACSSTEVNITVMDVNDNHPAFLRTSDEIR 987
             IRT   LDHET       V  +   +P   A S  EVNI V DVNDN P F +   E  
Sbjct: 1832 AIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETI 1891

Query: 988  ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL-NGSLGAGEQ 1046
            +   T  G  +    A D DS     + YS+       F ID   GVL + N +L    +
Sbjct: 1892 LLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNL---SK 1948

Query: 1047 RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106
                L ++  D   +  +    +  ++ K        F    Y   +SE+ + +T++   
Sbjct: 1949 DHYMLIVKVSDGKFYSTS----MVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIV 2004

Query: 1107 QAHPLGPQRAASPLRYS-LEPSVDSAMFGIRPYTGWIYLRR-QFDYESTQTYNFRVFAWI 1164
             A  +G  R   PL+YS L P      F I+  +G I      FD E  + Y   V A  
Sbjct: 2005 NA--VG-NRLNEPLKYSILNP---GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEA-S 2057

Query: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
             E   L+     V V + D NDNSP F+    +  V+    P  +I ++TAID D G NG
Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117

Query: 1225 QLLYFLLSDGKFFKMNPNTGELINWVALDREHRG-HHEMTVLVTDRGSPPRNATMAVYVS 1283
            ++ Y L  D   F++NPN+G +I   A + +     + +T+L  D G P  + + +V + 
Sbjct: 2118 EVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP--SLSTSVELP 2175

Query: 1284 VTDINDNRPFF 1294
            +T +N   P F
Sbjct: 2176 ITIVNKAMPVF 2186



 Score =  317 bits (813), Expect = 4e-86
 Identities = 347/1259 (27%), Positives = 519/1259 (41%), Gaps = 145/1259 (11%)

Query: 116  FHVHPDTGIIRTAR-RLDRERRDHYSFVAAT------LLGAVVQVEIRVNDVNDHSPRFP 168
            F +   +G+I+T     DRE ++ Y  V         L  A V V + + D+ND+SP F 
Sbjct: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085

Query: 169  LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
                   V   + PGT      A D D G      Y L       +D  G F        
Sbjct: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL-------QDDYGHF-------- 2130

Query: 229  GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAA--AHRLQIEAWDGGRPRRTGLLSVELRV 286
                  + P S +       V+L+     + +   + + I A DGG+P  +   SVEL +
Sbjct: 2131 -----EINPNSGN-------VILKEAFNSDLSNIEYGVTILAKDGGKPSLS--TSVELPI 2176

Query: 287  LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
               N   PVF++  Y A+V ED +    +  + AT  +    G +   +           
Sbjct: 2177 TIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE--GQGIIYIIID---------- 2224

Query: 347  GGALGDA-AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG--GAEPEVATVRVSIAV 403
                GD    F ++  +GV++V  PLD E  + ++L + A D   GA  EV    V + V
Sbjct: 2225 ----GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVT---VDLLV 2277

Query: 404  LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
             DVNDN P    +F        +SE +  G  V +V   DAD   E       ++     
Sbjct: 2278 NDVNDNPP----IFDQPTYNTTLSEASLIGTPVLQVVSIDADS--ENNKMVHYQIVQDTY 2331

Query: 464  DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE 523
            + +    ++   G              +     LD E      L + + D+G P LS+E 
Sbjct: 2332 NSTDYFHIDSSSG-------------LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEV 2378

Query: 524  TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
             + + ++D+ND PP+F+Q  Y++ VSE A  G  V  V ASDAD +  D   L Y+++  
Sbjct: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR--LEYSIL-- 2434

Query: 584  SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL 643
                           +     SF +DS+SG I+      + ++    L V   D      
Sbjct: 2435 ---------------SGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD---GLF 2476

Query: 644  SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
            ++T  V I V   N   P F +  Y A + E+   G   + V A+D D G YG I Y++ 
Sbjct: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536

Query: 704  DGFLSYEAPQAFRIDPHDGQICVSQDIDRERD-PATYDLLVEAKDGGGLSAQAFVRVDLE 762
            + F    A   F ID + GQ+  ++ +DRE        + V A DGGG +    VRV + 
Sbjct: 2537 NDF----AKDRFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVV 2591

Query: 763  DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG---NVSSLF 819
            D NDN P F    Y  S+  +   G  +  V A D D G    + Y L      +V+ L 
Sbjct: 2592 DENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLL 2651

Query: 820  TIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
             ID   G +      + L++T LS  V A DGG         V IH+         F + 
Sbjct: 2652 EIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711

Query: 880  KYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL-----GGKFSIHPRLGTIRT 934
            +Y+F + ED    S + T++    +  S+ +++   +G+      GG F I    GTI+ 
Sbjct: 2712 QYSFTIAEDTAIGSTVDTLR----ILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKL 2767

Query: 935  RKPLDHETQPVVVLTVQAQ--LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
             K LD ET P     V A   L       + +V+I V+D+NDN P F  +S +  I +  
Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGM 2827

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASP-QPG----VFAIDRALGVLFLNGSLGAGEQR 1047
            P GT L   RA D D G NG + YS+ S  QP      F ID   G +     L      
Sbjct: 2828 PVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDP 2887

Query: 1048 ELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 1105
              T ++ A D G      +  LV   V +  +++P   F   VY+  V ES  P   +  
Sbjct: 2888 TFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAP--VFAQEVYRGNVKESDPPGEVVAV 2945

Query: 1106 TQAHPLGPQRAASPLRYSLEPSVDSAMFGIR-PYTGW-IYLRRQFDYESTQTYNFRVFAW 1163
                          + Y +        F +    + W +Y++R  D E    Y   + A 
Sbjct: 2946 LSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITA- 3004

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGK 1222
               DG        V V V D NDNSP     V +  +    +P   +I K++A D D G 
Sbjct: 3005 --TDGLFVT-QAMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGS 3060

Query: 1223 NGQLLYFLLSDGKF-FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
            NG + Y L   G   F ++P +GEL     LDRE    + +    TD G   R     ++
Sbjct: 3061 NGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIH 3118

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
            + + D+NDN P F         +  V E      L+T V A DPD G N +V YS++ +
Sbjct: 3119 LILEDVNDNPPVFSS----DHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173



 Score =  288 bits (737), Expect = 2e-77
 Identities = 307/1144 (26%), Positives = 495/1144 (43%), Gaps = 178/1144 (15%)

Query: 282  VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
            V ++VLD ND  P+F    Y   + E       V +V ATD D+G NG   Y  + +   
Sbjct: 144  VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNK--- 200

Query: 342  GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-----PEVAT 396
                          F+V   SGV+ +   L+ + +  + L + A D G +        +T
Sbjct: 201  -----------VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSST 249

Query: 397  VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
             ++ + +  +N++ P IHV       V  V          A V+V D D      D A G
Sbjct: 250  AKLYVHIERINEHAPTIHV-------VTHVPFSLEKEPTYAVVTVDDLD------DGANG 296

Query: 457  ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGP------------LDRESRDL 504
            E+                    +++ G P   FFL  EG             +D ES   
Sbjct: 297  EIE-----------------SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPY 339

Query: 505  -YELLLVATDAGSPPLSTEETLLLRVADLNDQPPL-FSQQHYKASVSEAAAPGTVVMWVS 562
             Y L L A D GSP   +    +       D  P+ F ++ Y  S+SE + PG VV    
Sbjct: 340  GYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVV---- 395

Query: 563  ASDADEAGSDHAWLRYTVVQLSA-PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL 621
                             +V+LS  P ++       +   E    F I+  SG I T R L
Sbjct: 396  ----------------AIVKLSPEPIDV----EYKLSPGEDAVYFKINPRSGLIVTARPL 435

Query: 622  DREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHC 681
            +   +E  +L+V  +   E  L A   V+I+++D ND+ P F + +Y+A + E  PVG  
Sbjct: 436  NTVKKEVYKLEVTNK---EGDLKAQ--VTISIEDANDHTPEFQQPLYDAYVNESVPVGTS 490

Query: 682  FLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDL 741
             L V+ASD D G  G+I YS+    L       F I+   G I  ++++D E  P  Y  
Sbjct: 491  VLTVSASDKDKGENGYITYSIASLNLL-----PFVINQFTGVISTTEELDFESSPEIYRF 545

Query: 742  LVEAKDGGGL---SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798
            +V A D G      ++  V + + +VNDN P+F        IS +   G  I  V A D 
Sbjct: 546  IVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDI 605

Query: 799  DSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL--TLPLSHLESTTLSLMVSAQDGGGLT- 855
            D      V Y++I GN    F ++  +G++ L  +L  S +++   +L ++A DG  L  
Sbjct: 606  DE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663

Query: 856  ------AVINADVTIHIF---QTTLAPAEFER---------------------------P 879
                  +V++  V+   F   +T +A    E+                           P
Sbjct: 664  PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723

Query: 880  KYTFLVYEDVP--EDSPIGT----VKAREPLNS-SEPIFYRISSGDLGGKFSIHPRLGTI 932
             +      DV   ED P+G     +KA +  +  +  + + IS G+    F+I    G +
Sbjct: 724  YFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQL 783

Query: 933  RTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
            +   P+D E   + +L +    LG+    S   + I V D NDN P F++ S  + I ++
Sbjct: 784  KVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILES 843

Query: 992  TPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051
            +  GT +    A D+D G NG + YS+ +     FAI+ + G++++   L    +   +L
Sbjct: 844  SGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ-FAINSSTGIVYVADQLDRESKANYSL 902

Query: 1052 TLRAEDQGVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
             + A D+    Q    V+T+ +   +  + SP+  F    Y V+V E L   T +   + 
Sbjct: 903  KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA--FIPSSYSVKVLEDLPVGTVIAWLET 960

Query: 1109 HP----LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
            H     LG Q     +RYSL    +   F I   +G I L ++ DYE  Q YN  V A  
Sbjct: 961  HDPDLGLGGQ-----VRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRA-- 1012

Query: 1165 PEDGFLQNVSTT--VIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDS 1220
             + G   ++S+   V V V D N+N  +P F    +   V+E+      + ++TA D DS
Sbjct: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072

Query: 1221 GKNGQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G++G++ Y +        F ++  +G +     LDRE  G + +TV  TDRG  P  +T+
Sbjct: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTI 1132

Query: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
             VY+ V D+NDN P   + +     +  V+E  P ++ V  + A+DPD  +N ++TY ++
Sbjct: 1133 EVYIEVEDVNDNAPLTSEPI----YYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188

Query: 1339 SARP 1342
            S  P
Sbjct: 1189 SGNP 1192



 Score =  283 bits (723), Expect = 1e-75
 Identities = 305/1110 (27%), Positives = 467/1110 (42%), Gaps = 90/1110 (8%)

Query: 248  LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
            L ++  LD E  +A++L I A D     R  + +V+L V D NDNPP+F+Q  Y   + E
Sbjct: 2240 LKVVSPLDYEVTSAYKLTIRASDALTGARAEV-TVDLLVNDVNDNPPIFDQPTYNTTLSE 2298

Query: 308  DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
             +  G  V +V + D D   N  V Y +                   YF ++  SG++  
Sbjct: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQ----------DTYNSTDYFHIDSSSGLILT 2348

Query: 368  WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
             R LD E      L V + D G     + V V I + DVNDN P  + L       + VS
Sbjct: 2349 ARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE----SYVS 2404

Query: 428  EGARPGDYVARVSVSDADG-DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
            E A  G +V  V  SDAD  D+++                +  S+  G    + L     
Sbjct: 2405 ELAPRGHFVTCVQASDADSSDFDR----------------LEYSILSGNDRTSFLMDSKS 2448

Query: 487  GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
            GV  L       +    LY L +  +D      ++   + +RV   N   P FSQ  Y A
Sbjct: 2449 GVITL--SNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVA 2503

Query: 547  SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
             V E  A GT V+ V A+D D     +  + Y ++   A                    F
Sbjct: 2504 EVRENVAAGTKVIHVRATDGDPG--TYGQISYAIINDFAK-----------------DRF 2544

Query: 607  AIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
             IDS    I+T R LDRE     ++ +  + L     +  C V + V D NDN P F   
Sbjct: 2545 LIDSNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTV 2603

Query: 667  VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
             Y A++      GH   QV A D D G    I YSLY    S        IDP +G +  
Sbjct: 2604 EYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSE-ASVSVADLLEIDPDNGWMVT 2662

Query: 727  SQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH--PVFNPSTYVTSISDET 784
              + ++ ++       V+A DGG     + + V +  +      P F  S Y  +I+++T
Sbjct: 2663 KGNFNQLKN-TVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDT 2721

Query: 785  QPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSL 844
              G+ +  +      +  + TV  E    N   +F I+  TG I L   L    S     
Sbjct: 2722 AIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781

Query: 845  MVSAQDG-GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE- 902
             V+A      +  V   DV I +         FE   Y  ++ E +P  + +  V+A + 
Sbjct: 2782 KVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDM 2841

Query: 903  PLNSSEPIFYRISSGDLGGK----FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSA 957
               ++  + Y + S     K    F+I    G I T K LDHET P    +V A  LG A
Sbjct: 2842 DWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEA 2901

Query: 958  PACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD-SGRNGLIR 1015
             + SST  V++ V D+NDN P F +      + ++ PPG  + +    DRD S  N  + 
Sbjct: 2902 FSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVS 2961

Query: 1016 YSIASPQP-GVFAID--RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV 1072
            Y I    P G FA+   ++   +++   L   EQ    L + A D     QA  +V   V
Sbjct: 2962 YHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA--MVEVSV 3019

Query: 1073 IEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM 1132
             +  ++SP    + + Y   + E +     +L+  A       +   +RYSL  S +S  
Sbjct: 3020 SDVNDNSP--VCDQVAYTALLPEDIPSNKIILKVSAKD-ADIGSNGYIRYSLYGSGNSEF 3076

Query: 1133 FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFL 1192
            F + P +G +      D E    Y+    A    DG  +   + + + + D NDN P F 
Sbjct: 3077 F-LDPESGELKTLALLDRERIPVYSLMAKA---TDGGGRFCQSNIHLILEDVNDNPPVFS 3132

Query: 1193 HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL-SDGKFFKMNPNTGELINWVA 1251
             D     V E+   + ++ ++ A+D D G N +++Y L  S G  F ++ ++G +I    
Sbjct: 3133 SDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQP 3192

Query: 1252 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT--DINDNRPFFPQCLPGKELHVKVLE 1309
            LDRE +  + ++V  TD+ SP ++ +    V++T  DINDN P F +    ++  V V E
Sbjct: 3193 LDREQQSSYNISVRATDQ-SPGQSLSSLTTVTITVLDINDNPPVFER----RDYLVTVPE 3247

Query: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
                   V  VFA   D G NAE+TY + S
Sbjct: 3248 DTSPGTQVLAVFATSKDIGTNAEITYLIRS 3277



 Score =  282 bits (721), Expect = 2e-75
 Identities = 350/1309 (26%), Positives = 531/1309 (40%), Gaps = 161/1309 (12%)

Query: 70   TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF-FLSEDSDDSPLLDDFHVHPDTGIIRTA 128
            T SV+E +  +T +  I A  P     EG G  ++  D D       F++  DTG+++  
Sbjct: 2192 TASVNEDIRMNTPILSINATSP-----EGQGIIYIIIDGDP---FKQFNIDFDTGVLKVV 2243

Query: 129  RRLDRERRDHYSFV-----AATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
              LD E    Y        A T   A V V++ VNDVND+ P F   +    +SE S  G
Sbjct: 2244 SPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIG 2303

Query: 184  TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
            T     V+ D D+       Y +VQ +    D    +F +               SSS L
Sbjct: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTD----YFHI--------------DSSSGL 2345

Query: 244  EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
                ++  R LD E      L++ + D G P  +  + V + + D NDNPPVF Q  Y +
Sbjct: 2346 ----ILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401

Query: 304  AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
             V E A  G  V  V+A+D D      + YS+ +              D   F ++  SG
Sbjct: 2402 YVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGN------------DRTSFLMDSKSG 2449

Query: 364  VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGV 423
            V+ +     +  +  + L V   DG      +T +V I VL  N   PA    F     V
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGANLYSPA----FSQSTYV 2502

Query: 424  ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
            A V E    G  V  V  +D D                 G  S ++  +  +  F +   
Sbjct: 2503 AEVRENVAAGTKVIHVRATDGDPGT-------------YGQISYAIINDFAKDRFLIDSN 2549

Query: 484  GPPGVFFLCVEGPLDRES--RDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
            G      +     LDRE+       + + A D G    +T  T+ + V D ND  P F  
Sbjct: 2550 GQ-----VITTERLDRENPLEGDVSIFVRALDGGGR--TTFCTVRVIVVDENDNAPQFMT 2602

Query: 542  QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
              Y+ASV      G +V  V A D D+  +    + Y++    A  ++  L         
Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGANSR--ITYSLYS-EASVSVADL--------- 2650

Query: 602  CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                  ID ++G + T    ++     +   V A D G P   +   V I V       P
Sbjct: 2651 ----LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLP 2706

Query: 662  IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ-----AFR 716
             F +  Y+ TIAE   +G     +    + +     + +S  +G    E P+      F 
Sbjct: 2707 SFTQSQYSFTIAEDTAIGSTVDTLRILPSQN-----VWFSTVNG----ERPENNKGGIFV 2757

Query: 717  IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPS 774
            I+   G I + + +DRE  PA +  +        +     V VD++  D+NDN PVF  S
Sbjct: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETS 2817

Query: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI----PGNVSSLFTIDSTTGIIYL 830
            +Y T I +    GT++  V A D D G  G V Y L     P  V   F IDS TG I  
Sbjct: 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST 2877

Query: 831  TLPLSHLESTTLSLMVSAQDGG-----GLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
               L H    T +  V A D G       TA+++  VT               P +   V
Sbjct: 2878 LKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVT---------DINDNAPVFAQEV 2928

Query: 886  YE-DVPEDSPIGTVKA------REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT---- 934
            Y  +V E  P G V A      R+  + +  + Y I+ G+  G+F+    LG +++    
Sbjct: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFA----LGLVQSEWKV 2984

Query: 935  --RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
              ++PLD E Q +  L + A  G     +  EV+++  DVNDN P   + +    + +  
Sbjct: 2985 YVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVS--DVNDNSPVCDQVAYTALLPEDI 3042

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 1052
            P    +    A+D D G NG IRYS+       F +D   G L     L        +L 
Sbjct: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLM 3102

Query: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112
             +A D G     + + L ++ +  ++ P ++ +H  Y   V E+ +  T+ L T+   + 
Sbjct: 3103 AKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDH--YNTCVYENTA--TKALLTRVQAVD 3157

Query: 1113 PQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
            P    +  + YSL  S    +F I   +G I L +  D E   +YN  V A     G   
Sbjct: 3158 PDIGINRKVVYSLADSA-GGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSL 3216

Query: 1172 NVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 1231
            +  TTV + V D NDN P F      + V E   P   +  + A   D G N ++ Y + 
Sbjct: 3217 SSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIR 3276

Query: 1232 S---DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
            S    GK FK+NP TG +     LD E      + V   D G+P  +A   V +++TD+N
Sbjct: 3277 SGNEQGK-FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVN 3335

Query: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            DN P F Q +    +    L G  V +L+    A+D D   N ++ +S+
Sbjct: 3336 DNPPKFSQDVYSAVISEDALVGDSVILLI----AEDVDSQPNGQIHFSI 3380



 Score =  275 bits (704), Expect = 2e-73
 Identities = 319/1165 (27%), Positives = 492/1165 (42%), Gaps = 165/1165 (14%)

Query: 248  LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
            +V  R L+  +   ++L++   +G    +     V + + D ND+ P F+Q  Y A V E
Sbjct: 429  IVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPEFQQPLYDAYVNE 483

Query: 308  DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
                G  V  V A+D+D G NG++ YS+ +  +               F + + +GV+  
Sbjct: 484  SVPVGTSVLTVSASDKDKGENGYITYSIASLNL-------------LPFVINQFTGVIST 530

Query: 368  WRPLDREAQAW-HQLVVEARDGGAE-PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425
               LD E+    ++ +V A D G+     + V V+I + +VNDN P    LF        
Sbjct: 531  TEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP----LFEKVACQGV 586

Query: 426  VSEGARPGDYVARVSVSDADG-DWEKEDEATG-ELGV-------------------GLGD 464
            +S     G ++  VS  D D  +  K    +G ELG                    G+ +
Sbjct: 587  ISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKN 646

Query: 465  GSISLSLEGGEGD---------FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515
            G+ +L +   +G+          ++L G      F C E    R ++ L E LL+   A 
Sbjct: 647  GNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRE---TRVAQKLAEKLLIKAKAN 703

Query: 516  SPPLSTEETLLLRVADLNDQPPLFSQQHYK-ASVSEAAAPGTVVMWVSASDADEAGSDHA 574
               L+ E+  L     +N Q P F +      +V E    G  ++ + A DAD       
Sbjct: 704  GK-LNLEDGFL-DFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSG----- 756

Query: 575  WLRYTVVQLSAPCNLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDREVQEAVEL 631
                                K++ T   G +   F ID E+G +  +  +DRE  +   L
Sbjct: 757  -----------------FNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLL 799

Query: 632  KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
             +   DLG P  S+  L++I V+D NDN P+F +  Y+  I E + +G   +QV A D D
Sbjct: 800  NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859

Query: 692  SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGL 751
             G  G + YS+          Q F I+   G + V+  +DRE   A Y L +EA+D    
Sbjct: 860  LGSNGEVTYSVLTD------TQQFAINSSTGIVYVADQLDRE-SKANYSLKIEARDKAES 912

Query: 752  SAQAF----VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVA 807
              Q F    ++V L+DVND  P F PS+Y   + ++   GT I  +   D D G+ G V 
Sbjct: 913  GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR 972

Query: 808  YELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAVINADVTI 864
            Y L+  + +  F ID  +G I L+  L + +    +L V A+D G    L++V   +V +
Sbjct: 973  YSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEV 1031

Query: 865  HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAR-EPLNSSEPIFYRISSGDL 919
                  L    F      F V   V E+S IGT    V AR E       I Y I  G  
Sbjct: 1032 VDVNENLHTPYFP----DFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087

Query: 920  GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPA 978
             G+FSI    G I     LD ET     LTV A   G  P  S+ EV I V DVNDN P 
Sbjct: 1088 LGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPL 1147

Query: 979  FLRTSDEIR---ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGV 1034
               TS+ I    + + +P   ++   +AED DS  N  + Y I S  P   FAI+   G+
Sbjct: 1148 ---TSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL 1204

Query: 1035 LFLNG-SLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVE 1092
            +      L   +Q E  L +   D G  P Q+ + V+  V+++ ++ P   F   VYQ++
Sbjct: 1205 ITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ--FPEKVYQIK 1262

Query: 1093 VSESLSPMTQMLQTQAHPL----------GPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
            + E      +  + +  P+          GP    + + YS+    D   F I P TG +
Sbjct: 1263 LPE------RDRKKRGEPIYRAFAFDRDEGPN---AEISYSIVDGNDDGKFFIDPKTGMV 1313

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSP---TFLHDVLFL 1198
              R+QF   S      +      ++G  Q  ST  +   W  +   SP   TF       
Sbjct: 1314 SSRKQFTAGSYDILTIKAV----DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNF 1369

Query: 1199 KVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGELINWVALDRE 1255
             V ES     ++G ++    ++      L+F +  G F   F      G ++    LD E
Sbjct: 1370 TVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424

Query: 1256 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 1315
             R  + M+V VTD  +    A   V++ V D NDN P F Q        V + E    + 
Sbjct: 1425 QRSIYNMSVEVTDGTNV---AVTQVFIKVLDNNDNGPEFSQ----PNYDVTISEDVLPDT 1477

Query: 1316 LVTTVFAKDPDEGNNAEVTYSVSSA 1340
             +  + A D DE +  +++Y+V S+
Sbjct: 1478 EILQIEATDRDEKH--KLSYTVHSS 1500



 Score =  274 bits (700), Expect = 5e-73
 Identities = 326/1301 (25%), Positives = 535/1301 (41%), Gaps = 152/1301 (11%)

Query: 68   NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127
            N  +++ E + PDT +  I A     + ++    +    S DS  +  F + P TG++ T
Sbjct: 1464 NYDVTISEDVLPDTEILQIEA---TDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYT 1520

Query: 128  ARRLDRERRDHY---------SFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
            A RLD E +D +          F     L  V+   + V D NDHSP F     +  V E
Sbjct: 1521 AERLDHEAQDKHILNIMVRDQEFPYRRNLARVI---VNVEDANDHSPYFTNPLYEASVFE 1577

Query: 179  LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
             +  G+A     A D D G  +   YT+   +                           G
Sbjct: 1578 SAALGSAVLQVTALDKDKGENAELIYTIEAGN--------------------------TG 1611

Query: 239  SSSPLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
            +   +EP+   + + +  D        L I+  D G P  +    V + V   +++ P F
Sbjct: 1612 NMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKF 1671

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
               +Y+A V E+   G  V  + A  +       + Y V+   + G             F
Sbjct: 1672 IHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDING------------IF 1714

Query: 357  AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
             +   SGV+   + LD E  + +QL+++A +       AT  V+I ++D NDN P    +
Sbjct: 1715 TINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNAT--VNIQIVDENDNAP----V 1768

Query: 417  FLTEGGVARVSEGARPGDYVAR--------VSVSDADGDWEKEDEATGELGVGLGDGSIS 468
            FL       +SE A P + + R        +  +DAD +      A     +        
Sbjct: 1769 FLFSQYSGSLSEAA-PINSIVRSLDNSPLVIRATDADSN----RNALLVYQIVESTAKKF 1823

Query: 469  LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE--TLL 526
             +++   G    +               LD E+   +   +   D+GSP L+ E    + 
Sbjct: 1824 FTVDSSTGAIRTIAN-------------LDHETIAHFHFHVHVRDSGSPQLTAESPVEVN 1870

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
            + V D+ND PP+F+Q  ++  +      G  V+ VSA+D D        L Y++++    
Sbjct: 1871 IEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPE--LTYSLME---- 1924

Query: 587  CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
               GSL             F IDS SG + TI+  +      + +  V+    +    +T
Sbjct: 1925 ---GSLD-----------HFLIDSNSGVL-TIKNNNLSKDHYMLIVKVS----DGKFYST 1965

Query: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
             +V+I V +  D+   F +  Y+ +I+E+    +       +   + L   ++YS+ +  
Sbjct: 1966 SMVTIMVKEAMDSGLHFTQSFYSTSISENNT--NITKVAIVNAVGNRLNEPLKYSILN-- 2021

Query: 707  LSYEAPQAFRIDPHDGQI-CVSQDIDRERDPATYDLLVEA-KDGGGLS-AQAFVRVDLED 763
                    F+I    G I       DRE +   Y+L+VEA ++   L  A+  VRV++ED
Sbjct: 2022 ----PGNKFKIKSTSGVIQTTGVPFDRE-EQELYELVVEASRELDHLRVARVVVRVNIED 2076

Query: 764  VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 823
            +NDN PVF    Y  ++  + +PGT I  V A D+D G  G V Y L   +    F I+ 
Sbjct: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINP 2134

Query: 824  TTGIIYLTLPL-SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT 882
             +G + L     S L +    + + A+DGG     ++  V + I     A   F++P YT
Sbjct: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGG--KPSLSTSVELPITIVNKAMPVFDKPFYT 2192

Query: 883  FLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
              V ED+  ++PI ++ A  P    + I Y I  GD   +F+I    G ++   PLD+E 
Sbjct: 2193 ASVNEDIRMNTPILSINATSP--EGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEV 2250

Query: 943  QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 1002
                 LT++A      A +   V++ V DVNDN P F + +    +S+ +  GT +    
Sbjct: 2251 TSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVV 2310

Query: 1003 AEDRDSGRNGLIRYSIASP---QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG 1059
            + D DS  N ++ Y I          F ID + G++     L     +  TL +R+ D G
Sbjct: 2311 SIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSG 2370

Query: 1060 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
                ++ +++ + I     +P   F  L+Y+  VSE L+P    +               
Sbjct: 2371 FPSLSSEVLVHIYISDVNDNPP-VFNQLIYESYVSE-LAPRGHFVTCVQASDADSSDFDR 2428

Query: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
            L YS+    D   F +   +G I L           Y+  V      DG   + +  V +
Sbjct: 2429 LEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV---SDGLFTS-TAQVHI 2484

Query: 1180 RVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-GKFFK 1238
            RV   N  SP F       +V E+      +  + A D D G  GQ+ Y +++D  K   
Sbjct: 2485 RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRF 2544

Query: 1239 MNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCL 1298
            +  + G++I    LDRE+    ++++ V       R     V V V D NDN P F    
Sbjct: 2545 LIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVE 2604

Query: 1299 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
                +   V  G     LVT V A DPD+G N+ +TYS+ S
Sbjct: 2605 YRASVRADVGRGH----LVTQVQAIDPDDGANSRITYSLYS 2641



 Score =  265 bits (676), Expect = 3e-70
 Identities = 320/1235 (25%), Positives = 520/1235 (42%), Gaps = 153/1235 (12%)

Query: 113  LDDFHVHPDTGIIRTARRLDRERRDHYSFVAATL-----------LGAVVQVEIRVNDVN 161
            +D F VHP +G+I  + RL+ + ++ Y      +           + +  ++ + +  +N
Sbjct: 201  VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERIN 260

Query: 162  DHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFF 221
            +H+P   +                    V H P + L     Y +V   DL     G   
Sbjct: 261  EHAPTIHV--------------------VTHVPFS-LEKEPTYAVVTVDDLDDGANGEIE 299

Query: 222  QLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAA-AHRLQIEAWDGGRPRRTGLL 280
             +      PL    L      L    +   +++D E     + L ++A D G P++   L
Sbjct: 300  SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSAL 359

Query: 281  SVELRVLDENDNPPV-FEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
                      D  P+ FE++ Y  ++ E + PG  V  V+ +   +         V  + 
Sbjct: 360  KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPI--------DVEYKL 411

Query: 340  VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
             PG         DA YF +   SG++   RPL+   +  ++L V  ++G  +      +V
Sbjct: 412  SPGE--------DAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK-----AQV 458

Query: 400  SIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELG 459
            +I++ D ND+ P            A V+E    G  V  VS SD D          GE  
Sbjct: 459  TISIEDANDHTPEFQQPLYD----AYVNESVPVGTSVLTVSASDKD---------KGE-- 503

Query: 460  VGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESR-DLYELLLVATDAG 515
                +G I+ S+        LLP       GV     E  LD ES  ++Y  ++ A+D G
Sbjct: 504  ----NGYITYSI----ASLNLLPFVINQFTGVISTTEE--LDFESSPEIYRFIVRASDWG 553

Query: 516  SP-PLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
            SP    +E  + +R+ ++ND  PLF +   +  +S     G  +  VSA D DE      
Sbjct: 554  SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL----E 609

Query: 575  WLRYTVVQ--------LSAPCNLGSLQSKMVHTAECGPSFAI-----------DSESGAI 615
             ++Y ++         L+    +  L+  + ++     +FA+           D  S  I
Sbjct: 610  LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINI 669

Query: 616  STIRTLDREVQEAVELKVVAQDLGEPPL-SATCLVSITVDD-------VNDNEPIFWRQV 667
            S +         +     VAQ L E  L  A     + ++D       +N   P F +  
Sbjct: 670  SVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSF 729

Query: 668  -YNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
              +  + E  PVG   L++ A DADSG  G + +++ DG         F ID   GQ+ V
Sbjct: 730  PSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDG----NTDSCFNIDMETGQLKV 785

Query: 727  SQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDET 784
               +DRE     Y L +   D G    S+   + +++ED NDN PVF   +Y  +I + +
Sbjct: 786  LMPMDREHTD-LYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844

Query: 785  QPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSL 844
              GTEII V A D+D G  G V Y ++    +  F I+S+TGI+Y+   L        SL
Sbjct: 845  GIGTEIIQVEARDKDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSL 902

Query: 845  MVSAQDGGGLTAVINADVTIHIFQTTL---APAEFERPKYTFLVYEDVPEDSPIGTVKAR 901
             + A+D       + + VT+ +F   +   +PA F    Y+  V ED+P  + I  ++  
Sbjct: 903  KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA-FIPSSYSVKVLEDLPVGTVIAWLETH 961

Query: 902  EP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960
            +P L     + Y + + D  G+F I    G IR  K LD+E Q    LTV+A+    P  
Sbjct: 962  DPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS 1020

Query: 961  SSTE--VNITVMDVNDN--HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRY 1016
             S+   V + V+DVN+N   P F   +    + + +  GT++    A D DSGR+G I+Y
Sbjct: 1021 LSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080

Query: 1017 SIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK 1075
            SI      G F+ID   GV+     L         LT+ A D+GV P  + + + + +E 
Sbjct: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140

Query: 1076 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFG 1134
               +   T E + Y V V E+      ++Q QA    P  +++  L Y +        F 
Sbjct: 1141 VNDNAPLTSEPIYYPV-VMENSPKDVSVIQIQAE--DPDSSSNEKLTYRITSGNPQNFFA 1197

Query: 1135 IRPYTGWI-YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSPTFL 1192
            I   TG I    R+ D E    +   V   + + G     ST  V+V+V DENDN P F 
Sbjct: 1198 INIKTGLITTTSRKLDREQQAEHFLEV--TVTDGGPSPKQSTIWVVVQVLDENDNKPQFP 1255

Query: 1193 HDVLFLKVEESPVPQ--GVIGKITAIDMDSGKNGQLLYFLL---SDGKFFKMNPNTGELI 1247
              V  +K+ E    +    I +  A D D G N ++ Y ++    DGKFF ++P TG + 
Sbjct: 1256 EKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFF-IDPKTGMVS 1314

Query: 1248 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
            +          +  +T+   D G P +++T  +++
Sbjct: 1315 SRKQFTA--GSYDILTIKAVDNGRPQKSSTARLHI 1347



 Score =  254 bits (649), Expect = 4e-67
 Identities = 333/1296 (25%), Positives = 539/1296 (41%), Gaps = 157/1296 (12%)

Query: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT-ARRL 131
            V E  P D  V  I+A  P +   E   + ++  +  +     F ++  TG+I T +R+L
Sbjct: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQN----FFAINIKTGLITTTSRKL 1212

Query: 132  DRERR-DHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSE--LSPPG 183
            DRE++ +H+  V  T  G     + + V ++V D ND+ P+FP    Q+ + E      G
Sbjct: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRG 1272

Query: 184  TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
                   A D D G  +   Y++V  +D      G FF                     +
Sbjct: 1273 EPIYRAFAFDRDEGPNAEISYSIVDGND-----DGKFF---------------------I 1306

Query: 244  EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPV---FEQDE 300
            +P   ++  R      +   L I+A D GRP+++    + +  + +    P+   F++  
Sbjct: 1307 DPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366

Query: 301  YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
            Y   V E             +DR     G V  SV+    P      G   D+A F  E+
Sbjct: 1367 YNFTVME-------------SDRVTEIVGVV--SVQPANTPLWFDIVGGNFDSA-FDAEK 1410

Query: 361  LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
              G + + +PLD E ++ + + VE  DG     VA  +V I VLD NDN P     F   
Sbjct: 1411 GVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPE----FSQP 1463

Query: 421  GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
                 +SE   P   + ++  +D D   EK      +L   +     S+S+     D   
Sbjct: 1464 NYDVTISEDVLPDTEILQIEATDRD---EKH-----KLSYTVHSSIDSISMRKFRID--- 1512

Query: 481  LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
                 P    L     LD E++D + L ++  D   P       +++ V D ND  P F+
Sbjct: 1513 -----PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567

Query: 541  QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
               Y+ASV E+AA G+ V+ V+A D D+   ++A L YT                 +   
Sbjct: 1568 NPLYEASVFESAALGSAVLQVTALDKDK--GENAELIYT-----------------IEAG 1608

Query: 601  ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
              G  F I+   G I+  +  D        L +   D G PP+SAT +V I+V   +++ 
Sbjct: 1609 NTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668

Query: 661  PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH 720
            P F  + Y A + E+  +G   + ++A    +     + Y + DG ++      F I+P+
Sbjct: 1669 PKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDIN----GIFTINPY 1719

Query: 721  DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
             G I   + +D ER  ++Y L+++A +  G+++ A V + + D NDN PVF  S Y  S+
Sbjct: 1720 SGVITTQKALDYER-TSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSL 1778

Query: 781  SDETQPGTEIINVL--------ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTL 832
            S E  P   I+  L        ATD DS     + Y+++       FT+DS+TG I    
Sbjct: 1779 S-EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIA 1837

Query: 833  PLSHLESTTLSLMVSAQDGGG--LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 890
             L H         V  +D G   LTA    +V I +      P  F +  +  ++     
Sbjct: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897

Query: 891  EDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
                +  V A +P +   P + Y +  G L   F I    G +  +   ++ ++   +L 
Sbjct: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLTIKN--NNLSKDHYMLI 1954

Query: 950  VQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
            V+   G     S++ V I V +  D+   F ++     IS+     T + +  A    + 
Sbjct: 1955 VKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--GNR 2010

Query: 1010 RNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL-TLTLRAEDQGVHPQAALLV 1068
             N  ++YSI +P    F I    GV+   G     E++EL  L + A  +  H + A +V
Sbjct: 2011 LNEPLKYSILNP-GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVV 2069

Query: 1069 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLE 1125
            + V IE   ++SP   F  L Y   V     P T + Q  A     GP      + Y L+
Sbjct: 2070 VRVNIEDINDNSP--VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN---GEVTYVLQ 2124

Query: 1126 PSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDE 1184
               D   F I P +G + L+  F+ + S   Y   + A   +DG   ++ST+V + +   
Sbjct: 2125 D--DYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILA---KDGGKPSLSTSVELPITIV 2179

Query: 1185 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFKMNP 1241
            N   P F        V E       I  I A    +   GQ + +++ DG   K F ++ 
Sbjct: 2180 NKAMPVFDKPFYTASVNEDIRMNTPILSINA----TSPEGQGIIYIIIDGDPFKQFNIDF 2235

Query: 1242 NTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 1301
            +TG L     LD E    +++T+  +D  +  R A + V + V D+NDN P F Q     
Sbjct: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNT 2294

Query: 1302 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             L    L G PV  +V+     D D  NN  V Y +
Sbjct: 2295 TLSEASLIGTPVLQVVSI----DADSENNKMVHYQI 2326



 Score =  248 bits (634), Expect = 2e-65
 Identities = 319/1288 (24%), Positives = 525/1288 (40%), Gaps = 190/1288 (14%)

Query: 131  LDRERRDHYSFVAATL-----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
            L+RE +D+Y  +         L A  +V I+V D+ND  P F   +  + ++E +P  T+
Sbjct: 117  LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176

Query: 186  FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
                 A D D G      Y      DL        F + + T G +              
Sbjct: 177  VAQVTATDADIGSNGEFYYYFKNKVDL--------FSV-HPTSGVIS------------- 214

Query: 246  LDLVLLRRLDREEAAAHRLQIEAWDGGRP-------RRTGLLSVELRVLDENDNPPVFEQ 298
                L  RL+ +E   + L+I A D G           T  L V +  ++E+  P +   
Sbjct: 215  ----LSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH-APTIHVV 269

Query: 299  DEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAV 358
                 ++ ++         V   D D G NG         ++       G   D  + A 
Sbjct: 270  THVPFSLEKEPTYAV----VTVDDLDDGANG---------EIESVSIVAGDPLDQFFLAK 316

Query: 359  EELSGVVRVWRPLDREAQAW------HQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
            E     +  ++  +R+   W      + L ++A+D G+  + + ++   AV   N  R  
Sbjct: 317  E--GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK---AVYIGNPTRDT 371

Query: 413  IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
            + + F  E     +SE + PG  VA V +S    D E +        +  G+ ++   + 
Sbjct: 372  VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYK--------LSPGEDAVYFKIN 423

Query: 473  GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
               G              +    PL+   +++Y+L +   +        +  + + + D 
Sbjct: 424  PRSG-------------LIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIEDA 465

Query: 533  NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
            ND  P F Q  Y A V+E+   GT V+ VSASD D+   ++ ++ Y++  L+        
Sbjct: 466  NDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDK--GENGYITYSIASLNL------- 516

Query: 593  QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQ-EAVELKVVAQDLGEP-PLSATCLVS 650
                         F I+  +G IST   LD E   E     V A D G P    +   V+
Sbjct: 517  -----------LPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565

Query: 651  ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG----- 705
            I + +VNDN P+F +      I+   PVG     V+A D D      ++Y +  G     
Sbjct: 566  IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGF 623

Query: 706  -FLSYEA---------------------------------PQAFRIDPHDGQICVSQDID 731
             +L+ ++                                 P +  I    G++       
Sbjct: 624  FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683

Query: 732  RERDPA---TYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPS-TYVTSISDETQPG 787
            RE   A      LL++AK  G L+ +    +D   +N   P F+ S     ++ ++   G
Sbjct: 684  RETRVAQKLAEKLLIKAKANGKLNLEDGF-LDFYSINRQGPYFDKSFPSDVAVKEDLPVG 742

Query: 788  TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVS 847
              I+ + A D DSG  G V + +  GN  S F ID  TG + + +P+    +    L ++
Sbjct: 743  ANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNIT 802

Query: 848  AQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNS 906
              D G         +TI++         F +  Y+  + E     + I  V+AR+  L S
Sbjct: 803  IYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862

Query: 907  SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ---LGSAPACSST 963
            +  + Y + +     +F+I+   G +     LD E++    L ++A+          S  
Sbjct: 863  NGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVV 920

Query: 964  EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
             + + + DVND  PAF+ +S  +++ +  P GT +      D D G  G +RYS+ +   
Sbjct: 921  TLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN 980

Query: 1024 GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPS 1081
            G F ID+A G + L+  L   +Q+   LT+RA+D+G  V   +   V   V++  E+  +
Sbjct: 981  GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHT 1040

Query: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGW 1141
              F        V E+    T +LQ  A      R    ++YS+        F I   +G 
Sbjct: 1041 PYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGE-IQYSIRDGSGLGRFSIDDESGV 1099

Query: 1142 IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVLF-LK 1199
            I      D E+  +Y   V+A   + G +   ST  V + V D NDN+P     + + + 
Sbjct: 1100 ITAADILDRETMGSYWLTVYA--TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157

Query: 1200 VEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVA--LDRE 1255
            +E SP    VI +I A D DS  N +L Y + S     FF +N  TG LI   +  LDRE
Sbjct: 1158 MENSPKDVSVI-QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG-LITTTSRKLDRE 1215

Query: 1256 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE------ 1309
             +  H + V VTD G  P+ +T+ V V V D NDN+P FP+    K   +K+ E      
Sbjct: 1216 QQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPE----KVYQIKLPERDRKKR 1271

Query: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            G+P    +   FA D DEG NAE++YS+
Sbjct: 1272 GEP----IYRAFAFDRDEGPNAEISYSI 1295



 Score =  239 bits (610), Expect = 1e-62
 Identities = 273/1071 (25%), Positives = 440/1071 (41%), Gaps = 113/1071 (10%)

Query: 252  RRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQDEYRAAVRED 308
            + LD E  ++++L I+A +       G+ S   V ++++DENDN PVF   +Y  ++ E 
Sbjct: 1727 KALDYERTSSYQLIIQATN-----MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSE- 1780

Query: 309  AQPGAEVCR--------VRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
            A P   + R        +RATD D   N  + Y +                   +F V+ 
Sbjct: 1781 AAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK------------KFFTVDS 1828

Query: 361  LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVAT--VRVSIAVLDVNDNRPAIHVLFL 418
             +G +R    LD E  A     V  RD G+    A   V V+I V DVNDN P       
Sbjct: 1829 STGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVF 1888

Query: 419  TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
                +     G      V +VS +D D       E   EL   L +GS+   L       
Sbjct: 1889 ETILLLPTYVGVE----VLKVSATDPDS------EVPPELTYSLMEGSLDHFLIDSNSGV 1938

Query: 479  ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
              +                +  S+D Y L++  +D       +   + + V +  D    
Sbjct: 1939 LTIKN--------------NNLSKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMDSGLH 1981

Query: 539  FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
            F+Q  Y  S+SE     T V  V+A      G+          +L+ P     L      
Sbjct: 1982 FTQSFYSTSISENNTNITKVAIVNA-----VGN----------RLNEPLKYSILNP---- 2022

Query: 599  TAECGPSFAIDSESGAISTIRT-LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
                G  F I S SG I T     DRE QE  EL V A    +    A  +V + ++D+N
Sbjct: 2023 ----GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDIN 2078

Query: 658  DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
            DN P+F    Y A +   A  G    QVTA D D G  G + Y L D +  +E      I
Sbjct: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFE------I 2132

Query: 718  DPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 777
            +P+ G + + +  + +     Y + + AKDGG  S    V + +  VN   PVF+   Y 
Sbjct: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYT 2192

Query: 778  TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL 837
             S++++ +  T I+++ AT  +      + Y +I G+    F ID  TG++ +  PL + 
Sbjct: 2193 ASVNEDIRMNTPILSINATSPEG---QGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYE 2249

Query: 838  ESTTLSLMVSAQDG-GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI- 895
             ++   L + A D   G  A +  D+ ++       P  F++P Y   + E     +P+ 
Sbjct: 2250 VTSAYKLTIRASDALTGARAEVTVDLLVNDVNDN--PPIFDQPTYNTTLSEASLIGTPVL 2307

Query: 896  GTVKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 953
              V       +++ + Y+I          F I    G I T + LDHE      L V++ 
Sbjct: 2308 QVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSI 2367

Query: 954  LGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012
                P+ SS   V+I + DVNDN P F +   E  +S+  P G  +   +A D DS    
Sbjct: 2368 DSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFD 2427

Query: 1013 LIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 1071
             + YSI S      F +D   GV+ L+       +   +L +   D G+    A + +  
Sbjct: 2428 RLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-GLFTSTAQVHIR- 2485

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA 1131
            V+    +SP+  F    Y  EV E+++  T+++  +A   G       + Y++       
Sbjct: 2486 VLGANLYSPA--FSQSTYVAEVRENVAAGTKVIHVRATD-GDPGTYGQISYAIINDFAKD 2542

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 1191
             F I    G +    + D E+    +  +F     DG  +    TV V V DENDN+P F
Sbjct: 2543 RFLI-DSNGQVITTERLDRENPLEGDVSIFV-RALDGGGRTTFCTVRVIVVDENDNAPQF 2600

Query: 1192 LHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGK-----FFKMNPNTGE 1245
            +  V +     + V +G ++ ++ AID D G N ++ Y L S+         +++P+ G 
Sbjct: 2601 M-TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGW 2659

Query: 1246 LINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
            ++     ++         V   D G P +++ + VY+ V       P F Q
Sbjct: 2660 MVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710



 Score =  101 bits (251), Expect = 6e-21
 Identities = 124/466 (26%), Positives = 199/466 (42%), Gaps = 45/466 (9%)

Query: 904  LNSSEPIFYRISSGDLGGKFSIHPRLGT------IRTRKP----LDHETQPVVVLTVQAQ 953
            ++ S  I YRI SGD  G F     +        IRT+      L+ E Q   +L V+  
Sbjct: 73   IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132

Query: 954  LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
            +      + T+VNI V+D+ND  P F  T+  + I+++TP  T++    A D D G NG 
Sbjct: 133  VRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGE 192

Query: 1014 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV-----HPQAALLV 1068
              Y   + +  +F++    GV+ L+G L   E+    L + A D+G+     +  ++   
Sbjct: 193  FYYYFKN-KVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251

Query: 1069 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 1127
            L V IE+  EH+P+    H+V  V  S    P   ++       G       +       
Sbjct: 252  LYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308

Query: 1128 VDSAMFGIRPYTGW-----IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 1182
            +D   F +     W     I  R+Q D+ES   Y + +     + G  Q  S    V + 
Sbjct: 309  LDQ--FFLAKEGKWLNEYKIKERKQIDWESFP-YGYNLTLQAKDKGSPQKCSALKAVYIG 365

Query: 1183 DEN-DNSPT-FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFK 1238
            +   D  P  F  +V  + + E   P    G + AI   S +   + Y L    D  +FK
Sbjct: 366  NPTRDTVPIRFEKEVYDVSISEFSPP----GVVVAIVKLSPEPIDVEYKLSPGEDAVYFK 421

Query: 1239 MNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCL 1298
            +NP +G ++    L+   +  +++ V      +   +    V +S+ D ND+ P F Q L
Sbjct: 422  INPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHTPEFQQPL 476

Query: 1299 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMP 1344
                    V E  PV   V TV A D D+G N  +TYS++S   +P
Sbjct: 477  ----YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP 518



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 23/181 (12%)

Query: 1175 TTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG 1234
            T V ++V D ND  P F      + + ES   +  + ++TA D D G NG+  Y+  +  
Sbjct: 142  TKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKV 201

Query: 1235 KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR-----GSPPRNATMAVYVSVTDIND 1289
              F ++P +G +     L+ + +  +++ +L  DR     G+   ++T  +YV +  IN+
Sbjct: 202  DLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINE 261

Query: 1290 NRPFFPQCLPGKELHVKV-----LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMP 1344
            + P          +HV       LE +P   +VT     D D+G N E+  SVS     P
Sbjct: 262  HAP---------TIHVVTHVPFSLEKEPTYAVVT---VDDLDDGANGEIE-SVSIVAGDP 308

Query: 1345 L 1345
            L
Sbjct: 309  L 309


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score =  334 bits (857), Expect = 3e-91
 Identities = 295/999 (29%), Positives = 441/999 (44%), Gaps = 100/999 (10%)

Query: 165  PRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLR 224
            P+FP  + Q  V E    GTA    VA DPDAG      Y+L                  
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL------------------ 364

Query: 225  YRTPGPLPSPLLPGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
                    + L+   S  L  +D     +     LDRE    H L++ A D G PR +  
Sbjct: 365  --------AALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSAT 416

Query: 280  LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
              V + V D ND+ PVFEQ +YR  +RE+ + G  + ++RATD D  PN  +RY      
Sbjct: 417  TMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRF---- 472

Query: 340  VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE--PEVATV 397
                G        AA F ++  SG++     +DRE    ++LVVEA D G E  P  ATV
Sbjct: 473  ---VGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529

Query: 398  RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
            RV I VLD NDN P     F  +  VA+V E  RP   V RV+ +D D D      A G 
Sbjct: 530  RVHITVLDENDNAPQ----FSEKRYVAQVREDVRPHTVVLRVTATDRDKD------ANGL 579

Query: 458  LGVGLGDGSISLSLEGGEGDFAL--LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515
            +   +  G+         G FA+  L G       + V  PLD E+   Y L + A DAG
Sbjct: 580  VHYNIISGN-------SRGHFAIDSLTGE------IQVVAPLDFEAEREYALRIRAQDAG 626

Query: 516  SPPLSTEETLL-LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
             PPLS    L  ++V D+ND  P+F    ++ SV E A  G  V+ + A DAD    ++A
Sbjct: 627  RPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADH--GENA 684

Query: 575  WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
             L Y++  ++                     F I+S +G +S    LDRE  E     V 
Sbjct: 685  RLEYSLTGVAP-----------------DTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727

Query: 635  AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGL 694
            A+D G PPLSA+  V++TV DVNDN P F  + Y+  + E A VG   + VTA D D+  
Sbjct: 728  ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786

Query: 695  YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ 754
               I Y +  G         F I    G   V+  +  +     Y  LV       L   
Sbjct: 787  -SAISYQITGG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841

Query: 755  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 814
             +V +++ D N + PVF  + Y  S++++   G+ I+ + A+D D G    + Y L+  N
Sbjct: 842  CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDN 900

Query: 815  VSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
            +   F ID+ +G I L  PL + +  T +L ++A+D G         V + +        
Sbjct: 901  LPQ-FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP 959

Query: 875  EFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG-GKFSIHPRLGTI 932
            +F    YT LV ED P  + +  + A +   +++  + Y   +G+ G G F+I P  G +
Sbjct: 960  QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019

Query: 933  RTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
            RT + LD E   V  LT  A   G  P  +   + + V DVNDN P F     E+R+ + 
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079

Query: 992  TPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELT 1050
            +  G+ +    A D D G N  I Y I     P +F +D   G L     L    ++E  
Sbjct: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139

Query: 1051 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
            + ++A    +  +A + V   ++++ ++SP      +++   VS         +  +   
Sbjct: 1140 IVVQATSAPLVSRATVHVR--LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197

Query: 1111 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149
              P   +  L YS E   +  +  +   +G + L R+ D
Sbjct: 1198 YDPD-VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235



 Score =  318 bits (814), Expect = 3e-86
 Identities = 264/826 (31%), Positives = 378/826 (45%), Gaps = 67/826 (8%)

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDAD--EAGSDHAWLRYTVVQLSAPCNLGSLQS 594
            P F Q +Y+  V E  A GT V+ V A D D  EAG         V  L+A  N  SL+ 
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGR-------LVYSLAALMNSRSLEL 375

Query: 595  KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
                       F+ID +SG I T   LDRE  E   L+V AQD G P LSAT +V++TV 
Sbjct: 376  -----------FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVA 424

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY-DGFLSYEAPQ 713
            D ND+ P+F +  Y  T+ E+   G+  LQ+ A+D D+     + Y           A  
Sbjct: 425  DRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAA 484

Query: 714  AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD----GGGLSAQAFVRVDLEDVNDNHP 769
            AF IDP  G I  S  +DRE    +Y+L+VEA D     G  SA   V + + D NDN P
Sbjct: 485  AFEIDPRSGLISTSGRVDREH-MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAP 543

Query: 770  VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY 829
             F+   YV  + ++ +P T ++ V ATD+D    G V Y +I GN    F IDS TG I 
Sbjct: 544  QFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQ 603

Query: 830  LTLPLSHLESTTLSLMVSAQDGG--------GLTAVINADVTIHIFQTTLAPAEFERPKY 881
            +  PL        +L + AQD G        GL ++   D+  HI         F    +
Sbjct: 604  VVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-------PIFVSTPF 656

Query: 882  TFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 940
               V E+ P    +  ++A +  +     + Y ++       F I+   G +    PLD 
Sbjct: 657  QVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDR 716

Query: 941  ETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY 999
            E+       V+A+  GS P  +S  V +TV+DVNDN P F      +R+++    GT++ 
Sbjct: 717  ESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVV 776

Query: 1000 LARAEDRDSGRNGLIRYSIASPQP-GVFAIDR--ALGVLFLNGSLGAGEQRELTLTLRAE 1056
               A DRD+  N  I Y I        FAI     +G++ L   L   ++R   L L A 
Sbjct: 777  SVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTAS 834

Query: 1057 DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 1116
            D+ +H      V   + +   H P   F+   Y V V+E   PM   +   +        
Sbjct: 835  DRALHDHC--YVHINITDANTHRP--VFQSAHYSVSVNED-RPMGSTIVVISASDDDVGE 889

Query: 1117 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 1176
             + + Y LE ++    F I   +G I L+   DYE   TY   + A   ++G  Q   TT
Sbjct: 890  NARITYLLEDNL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITA--RDNGIPQKADTT 945

Query: 1177 VI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS--- 1232
             + V V D NDN+P F+       V E   P   + +I+A D D+  NG++ Y   +   
Sbjct: 946  YVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGED 1005

Query: 1233 -DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
             DG  F + P +G +     LDRE    +E+T    DRG PP    +++ V V D+NDN 
Sbjct: 1006 GDGD-FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNA 1064

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            P F    P +E  V+V E   V  +V  + A DPDEG NA + Y +
Sbjct: 1065 PVF----PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI 1106



 Score =  303 bits (775), Expect = 1e-81
 Identities = 292/996 (29%), Positives = 439/996 (44%), Gaps = 122/996 (12%)

Query: 109  DSPLLDDFHVHPDTGIIRTARRLDRERRD-HYSFVAA-----TLLGAVVQVEIRVNDVND 162
            +S  L+ F + P +G+IRTA  LDRE  + HY  V A       L A   V + V D ND
Sbjct: 369  NSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRND 428

Query: 163  HSPRFP----LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
            HSP F      ++L+ +V E                        GY ++Q      D A 
Sbjct: 429  HSPVFEQAQYRETLRENVEE------------------------GYPILQLRATDGD-AP 463

Query: 219  PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLR--RLDREEAAAHRLQIEAWDGGRP-- 274
            P   LRYR  GP  +     ++  ++P   ++    R+DRE   ++ L +EA D G+   
Sbjct: 464  PNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPG 523

Query: 275  RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
             R+  + V + VLDENDN P F +  Y A VRED +P   V RV ATDRD   NG V Y+
Sbjct: 524  PRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYN 583

Query: 335  VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP-E 393
            +    + G   G        +FA++ L+G ++V  PLD EA+  + L + A+D G  P  
Sbjct: 584  I----ISGNSRG--------HFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLS 631

Query: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
              T   SI V+D+ND+ P    +F++      V E A  G  V  +   DAD        
Sbjct: 632  NNTGLASIQVVDINDHIP----IFVSTPFQVSVLENAPLGHSVIHIQAVDAD-------- 679

Query: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
              GE      +  +  SL G   D   +     G  ++ V GPLDRES + Y   + A D
Sbjct: 680  -HGE------NARLEYSLTGVAPDTPFVINSATG--WVSVSGPLDRESVEHYFFGVEARD 730

Query: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
             GSPPLS   ++ + V D+ND  P F+ + Y   ++E AA GT V+ V+A D D   +  
Sbjct: 731  HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA-- 788

Query: 574  AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA--ISTIRTLDREVQEAVEL 631
                     +S     G+ +++          FAI ++ G   ++    LD + +   +L
Sbjct: 789  ---------ISYQITGGNTRNR----------FAISTQGGVGLVTLALPLDYKQERYFKL 829

Query: 632  KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
             + A D     L   C V I + D N + P+F    Y+ ++ E  P+G   + ++ASD D
Sbjct: 830  VLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886

Query: 692  SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-- 749
             G    I Y L D       PQ FRID   G I +   +D E D  TY L + A+D G  
Sbjct: 887  VGENARITYLLEDNL-----PQ-FRIDADSGAITLQAPLDYE-DQVTYTLAITARDNGIP 939

Query: 750  GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE 809
              +   +V V + DVNDN P F  S Y   +S++  P T ++ + ATD+D+   G V Y 
Sbjct: 940  QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999

Query: 810  LIPG-NVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 868
               G +    FTI+ T+GI+     L     +   L   A D G         + + +  
Sbjct: 1000 FQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQD 1059

Query: 869  TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 927
                   F   ++   V E+    S +  + A +P    +  I Y+I  G++   F +  
Sbjct: 1060 VNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDI 1119

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA-----FLRT 982
              G +     LD+E +   V+ VQA   SAP  S   V++ ++D NDN P       L  
Sbjct: 1120 FSGELTALIDLDYEARQEYVIVVQAT--SAPLVSRATVHVRLVDQNDNSPVLNNFQILFN 1177

Query: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVLFLNGSL 1041
            +     S T P G    + R    D   +  + YS     +  +  +++  G L L+  L
Sbjct: 1178 NYVSNRSDTFPSG---IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKL 1234

Query: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKRE 1077
                    ++ +   D G+H   A  VL VVI   E
Sbjct: 1235 DNNRPLVASMLVTVTD-GLHSVTAQCVLRVVIITEE 1269



 Score =  301 bits (770), Expect = 4e-81
 Identities = 282/998 (28%), Positives = 440/998 (44%), Gaps = 93/998 (9%)

Query: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
            P F Q  Y+  V E+   G  V RV A D D G  G + YS+ A     +          
Sbjct: 323  PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRS---------L 373

Query: 354  AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI 413
              F+++  SG++R    LDRE+   H L V A+D G+    AT  V++ V D ND+ P  
Sbjct: 374  ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVF 433

Query: 414  HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG 473
                  E     + E    G  + ++  +D D                  + ++     G
Sbjct: 434  EQAQYRE----TLRENVEEGYPILQLRATDGDAP---------------PNANLRYRFVG 474

Query: 474  GEGDFALLPGG---PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
                 A         P    +   G +DRE  + YEL++ A+D G  P     T+ + + 
Sbjct: 475  PPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHIT 534

Query: 531  --DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
              D ND  P FS++ Y A V E   P TVV+ V+A+D D+  +    + Y ++       
Sbjct: 535  VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDAN--GLVHYNII------- 585

Query: 589  LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA-TC 647
                      +      FAIDS +G I  +  LD E +    L++ AQD G PPLS  T 
Sbjct: 586  ----------SGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635

Query: 648  LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFL 707
            L SI V D+ND+ PIF    +  ++ E+AP+GH  + + A DAD G    +EYSL    +
Sbjct: 636  LASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG--V 693

Query: 708  SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVN 765
            + + P  F I+   G + VS  +DRE     Y   VEA+D G   LSA A V V + DVN
Sbjct: 694  APDTP--FVINSATGWVSVSGPLDRE-SVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750

Query: 766  DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST- 824
            DN P F    Y   ++++   GT +++V A D+D+     ++Y++  GN  + F I +  
Sbjct: 751  DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQITGGNTRNRFAISTQG 808

Query: 825  -TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
              G++ L LPL + +     L+++A D        +  V I+I         F+   Y+ 
Sbjct: 809  GVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSV 865

Query: 884  LVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
             V ED P  S I  + A +  +  +  I Y +   D   +F I    G I  + PLD+E 
Sbjct: 866  SVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFRIDADSGAITLQAPLDYED 923

Query: 943  QPVVVLTVQAQLGSAPA-CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
            Q    L + A+    P    +T V + V DVNDN P F+ +     +S+  PP T++   
Sbjct: 924  QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQI 983

Query: 1002 RAEDRDSGRNGLIRYSIASPQPGV--FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG 1059
             A DRD+  NG ++Y+  + + G   F I+   G++     L         LT  A D+G
Sbjct: 984  SATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRG 1043

Query: 1060 VHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118
            V P    + + V+++   +++P +  E    +V+ +  +  +   +       GP    +
Sbjct: 1044 VPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN---A 1100

Query: 1119 PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS-TTV 1177
             + Y +       +F +  ++G +      DYE+ Q Y   V A          VS  TV
Sbjct: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAP-----LVSRATV 1155

Query: 1178 IVRVWDENDNSPTFLH-DVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
             VR+ D+NDNSP   +  +LF   +       P G+IG+I A D D   +   L++    
Sbjct: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH---LFYSFER 1212

Query: 1234 G---KFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
            G   +   +N  +GEL     LD        M V VTD
Sbjct: 1213 GNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250



 Score =  202 bits (513), Expect = 2e-51
 Identities = 185/696 (26%), Positives = 303/696 (43%), Gaps = 33/696 (4%)

Query: 658  DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
            +  P F +  Y   + E+   G   L+V A D D+G  G + YSL    ++  + + F I
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL-AALMNSRSLELFSI 378

Query: 718  DPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPST 775
            DP  G I  +  +DRE     Y L V A+D G   LSA   V V + D ND+ PVF  + 
Sbjct: 379  DPQSGLIRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437

Query: 776  YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-----PGNVSSLFTIDSTTGIIYL 830
            Y  ++ +  + G  I+ + ATD D+     + Y  +         ++ F ID  +G+I  
Sbjct: 438  YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497

Query: 831  TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF---QTTLAPAEFERPKYTFLVYE 887
            +  +      +  L+V A D G      +A V +HI    +   AP +F   +Y   V E
Sbjct: 498  SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAP-QFSEKRYVAQVRE 556

Query: 888  DVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
            DV   + +  V A +   +++  + Y I SG+  G F+I    G I+   PLD E +   
Sbjct: 557  DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616

Query: 947  VLTVQAQLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
             L ++AQ    P  S+     +I V+D+ND+ P F+ T  ++ + +  P G ++   +A 
Sbjct: 617  ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676

Query: 1005 DRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
            D D G N  + YS+    P   F I+ A G + ++G L           + A D G  P 
Sbjct: 677  DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPL 736

Query: 1064 AALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRY 1122
            +A   +TV V++  ++ P +T +   Y + ++E  +  T ++   A     + A S + Y
Sbjct: 737  SASASVTVTVLDVNDNRPEFTMKE--YHLRLNEDAAVGTSVVSVTA---VDRDANSAISY 791

Query: 1123 SLEPSVDSAMFGIRPY--TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 1180
             +        F I      G + L    DY+  + +   + A    D  L +    V + 
Sbjct: 792  QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA---SDRALHD-HCYVHIN 847

Query: 1181 VWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMN 1240
            + D N + P F      + V E       I  I+A D D G+N ++ Y L  +   F+++
Sbjct: 848  ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID 907

Query: 1241 PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
             ++G +     LD E +  + + +   D G P +  T  V V V D+NDN P F      
Sbjct: 908  ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF----VA 963

Query: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS 1336
                  V E  P    V  + A D D   N  V Y+
Sbjct: 964  SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999



 Score =  176 bits (445), Expect = 2e-43
 Identities = 165/598 (27%), Positives = 251/598 (41%), Gaps = 36/598 (6%)

Query: 766  DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTID 822
            + HP F    Y T + +    GT ++ V+A D D+G  G + Y    L+      LF+ID
Sbjct: 320  NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379

Query: 823  STTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT 882
              +G+I     L         L V+AQD G         V + +         FE+ +Y 
Sbjct: 380  PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439

Query: 883  FLVYEDVPEDSPIGTVKARE---PLNSSEPIFYRI-----SSGDLGGKFSIHPRLGTIRT 934
              + E+V E  PI  ++A +   P N++  + YR      +       F I PR G I T
Sbjct: 440  ETLRENVEEGYPILQLRATDGDAPPNAN--LRYRFVGPPAARAAAAAAFEIDPRSGLIST 497

Query: 935  RKPLDHETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
               +D E      L V+A        P  ++  V+ITV+D NDN P F       ++ + 
Sbjct: 498  SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557

Query: 992  TPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELT 1050
              P T +    A DRD   NGL+ Y+I S    G FAID   G + +   L    +RE  
Sbjct: 558  VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYA 617

Query: 1051 LTLRAEDQGVHPQA--ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
            L +RA+D G  P +    L    V++  +H P   F    +QV V E+      ++  QA
Sbjct: 618  LRIRAQDAGRPPLSNNTGLASIQVVDINDHIP--IFVSTPFQVSVLENAPLGHSVIHIQA 675

Query: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
                    A  L YSL        F I   TGW+ +    D ES + Y F V A      
Sbjct: 676  VDADHGENAR-LEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 734

Query: 1169 FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY 1228
             L + S +V V V D NDN P F      L++ E       +  +TA+D D+  N  + Y
Sbjct: 735  PL-SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISY 791

Query: 1229 FLLSDGKFFKMNPNT----GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSV 1284
             +       +   +T    G +   + LD +   + ++ +  +DR     +    V++++
Sbjct: 792  QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINI 848

Query: 1285 TDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
            TD N +RP F          V V E +P+   +  + A D D G NA +TY +    P
Sbjct: 849  TDANTHRPVFQSA----HYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLP 902



 Score =  107 bits (268), Expect = 6e-23
 Identities = 100/389 (25%), Positives = 160/389 (41%), Gaps = 54/389 (13%)

Query: 65   QLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
            Q  + ++SV+E  P    +G     + A+    G    ++   +D+  L  F +  D+G 
Sbjct: 859  QSAHYSVSVNEDRP----MGSTIVVISASDDDVGENARITYLLEDN--LPQFRIDADSGA 912

Query: 125  IRTARRLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPRFPLDSLQLDVSE 178
            I     LD E +  Y+         + Q      VE+ VNDVND++P+F        VSE
Sbjct: 913  ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972

Query: 179  LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
             +PP T+     A D DA       YT     D   D                       
Sbjct: 973  DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD----------------------- 1009

Query: 239  SSSPLEPLDLVL--LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
                +EP   ++  +RRLDRE  + + L   A D G P     +S+++ V D NDN PVF
Sbjct: 1010 --FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
              +E+   V+E++  G+ V ++ A D D GPN  + Y +    +P              F
Sbjct: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIP------------ELF 1115

Query: 357  AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
             ++  SG +     LD EA+  + +VV+A    + P V+   V + ++D NDN P ++  
Sbjct: 1116 QMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNF 1172

Query: 417  FLTEGGVARVSEGARPGDYVARVSVSDAD 445
             +             P   + R+   D D
Sbjct: 1173 QILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201



 Score = 77.4 bits (189), Expect = 9e-14
 Identities = 85/326 (26%), Positives = 134/326 (41%), Gaps = 54/326 (16%)

Query: 73   VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
            V E  PP T V  I A    A    G   +  ++ +D     DF + P +GI+RT RRLD
Sbjct: 970  VSEDAPPFTSVLQISATDRDAHAN-GRVQYTFQNGEDGD--GDFTIEPTSGIVRTVRRLD 1026

Query: 133  RERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
            RE    Y   A  +      L   V +++ V DVND++P FP +  ++ V E S  G+  
Sbjct: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086

Query: 187  RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
                A DPD G  +   Y +V+  ++P+      FQ+           +  G        
Sbjct: 1087 AQITAVDPDEGPNAHIMYQIVE-GNIPE-----LFQM----------DIFSG-------- 1122

Query: 247  DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY----R 302
            +L  L  LD E    + + ++A       R    +V +R++D+NDN PV    +      
Sbjct: 1123 ELTALIDLDYEARQEYVIVVQATSAPLVSRA---TVHVRLVDQNDNSPVLNNFQILFNNY 1179

Query: 303  AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             + R D  P   + R+ A D D+  + F  +  R  ++                 V + S
Sbjct: 1180 VSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFE-RGNEL-------------QLLVVNQTS 1225

Query: 363  GVVRVWRPLDREAQAWHQLVVEARDG 388
            G +R+ R LD        ++V   DG
Sbjct: 1226 GELRLSRKLDNNRPLVASMLVTVTDG 1251


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score =  333 bits (855), Expect = 5e-91
 Identities = 307/1010 (30%), Positives = 446/1010 (44%), Gaps = 107/1010 (10%)

Query: 156  RVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKD 215
            R  +VN  +P+F   S Q  V E  P GT      A DPD G      YT+    D    
Sbjct: 171  RKRNVNT-APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFD---S 226

Query: 216  PAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPR 275
             +  FF L   T          G+ +  E         LDRE  + H  ++ A D G PR
Sbjct: 227  RSNQFFSLDPVT----------GAVTTAE--------ELDRETKSTHVFRVTAQDHGMPR 268

Query: 276  RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV 335
            R+ L ++ + V D ND+ PVFEQ EY+ ++RE+ + G EV  VRATD D  PN  + Y +
Sbjct: 269  RSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRL 328

Query: 336  RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE--PE 393
                    GSGG     +  F ++  SGV+R   P+DRE    +QL VEA D G +  P 
Sbjct: 329  L------EGSGG---SPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR 379

Query: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
              T  V ++V D NDN P     F  +  V +V E   PG  V RV+ SD D    K   
Sbjct: 380  STTAAVFLSVEDDNDNAPQ----FSEKRYVVQVREDVTPGAPVLRVTASDRD----KGSN 431

Query: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
            A     +  G+      L+   G              L V  PLD E+   Y L + A D
Sbjct: 432  AVVHYSIMSGNARGQFYLDAQTG-------------ALDVVSPLDYETTKEYTLRVRAQD 478

Query: 514  AGSPPLSTEETLL-LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSD 572
             G PPLS    L+ ++V D+ND  P+F    ++A+V E+   G +V+ V A DAD    D
Sbjct: 479  GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD--AGD 536

Query: 573  HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632
            +A L Y +  +                      F I++ +G IS    LDRE  +     
Sbjct: 537  NARLEYRLAGVGHDF-----------------PFTINNGTGWISVAAELDREEVDFYSFG 579

Query: 633  VVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS 692
            V A+D G P L+A+  VS+TV DVNDN P F +  Y   + E A VG   + V+A D D+
Sbjct: 580  VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639

Query: 693  GLYGFIEYSLYDGFLSYEAPQAFRIDPHDG----QICVSQDIDRERDPATYDLLVEAKDG 748
              +  I Y +  G         F I    G     + +  D   ER    Y L V A DG
Sbjct: 640  --HSVITYQITSG----NTRNRFSITSQSGGGLVSLALPLDYKLERQ---YVLAVTASDG 690

Query: 749  GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAY 808
                    V V++ D N + PVF  S Y  +++++   GT ++ + ATD+D+G    + Y
Sbjct: 691  TRQDTAQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749

Query: 809  ---ELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 865
               + IP      F ID+ TG +     L + +  + +L ++A+D G         + I 
Sbjct: 750  FMEDSIP-----QFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEIL 804

Query: 866  IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG-GKF 923
            +        +F R  Y   VYEDVP  + +  + A +     +  +FY    GD G G F
Sbjct: 805  VNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864

Query: 924  SIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRT 982
             +    G +RT + LD E     VL   A   G  PA +  EV +TV+DVNDN P F + 
Sbjct: 865  IVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQD 924

Query: 983  SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSL 1041
              ++ + + +P G A+    A D D G N  I Y I     P VF +D   G L     L
Sbjct: 925  EFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDL 984

Query: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP-SWTFEHLVYQVEVSESLS-P 1099
               ++ E  L ++A    +  +A + V   ++++ ++ P    FE L      + S S P
Sbjct: 985  DYEDRPEYVLVIQATSAPLVSRATVHVR--LLDRNDNPPVLGNFEILFNNYVTNRSSSFP 1042

Query: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149
               + +  AH       +  L YS E   + ++  +   TG + L R  D
Sbjct: 1043 GGAIGRVPAH---DPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089



 Score =  317 bits (811), Expect = 7e-86
 Identities = 291/1001 (29%), Positives = 446/1001 (44%), Gaps = 101/1001 (10%)

Query: 294  PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
            P F+   Y+A V E+   G  V  +RA D D G  G + Y++             AL D+
Sbjct: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM------------DALFDS 226

Query: 354  A---YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
                +F+++ ++G V     LDRE ++ H   V A+D G     A   ++I V D ND+ 
Sbjct: 227  RSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHD 286

Query: 411  PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
            P        E     + E    G  V  V  +D D                  + +I   
Sbjct: 287  PVFEQQEYKES----LRENLEVGYEVLTVRATDGDAP---------------PNANILYR 327

Query: 471  LEGGEGDFALLPGGPPGVF-------FLCVEGPLDRESRDLYELLLVATDAGSPP--LST 521
            L  G G      G P  VF        +   GP+DRE  + Y+L + A+D G  P   ST
Sbjct: 328  LLEGSG------GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRST 381

Query: 522  EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
               + L V D ND  P FS++ Y   V E   PG  V+ V+ASD D+  +  A + Y+++
Sbjct: 382  TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSN--AVVHYSIM 439

Query: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP 641
              +A                    F +D+++GA+  +  LD E  +   L+V AQD G P
Sbjct: 440  SGNAR-----------------GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP 482

Query: 642  PLS-ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
            PLS  + LV++ V D+NDN PIF    + AT+ E  P+G+  L V A DAD+G    +EY
Sbjct: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542

Query: 701  SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVR 758
             L    + ++ P  F I+   G I V+ ++DRE +   Y   VEA+D G   L+A A V 
Sbjct: 543  RLAG--VGHDFP--FTINNGTGWISVAAELDRE-EVDFYSFGVEARDHGTPALTASASVS 597

Query: 759  VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
            V + DVNDN+P F    Y   ++++   GT ++ V A D+D+  +  + Y++  GN  + 
Sbjct: 598  VTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNR 655

Query: 819  FTIDSTTG--IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
            F+I S +G  ++ L LPL +       L V+A DG   T    A + +++         F
Sbjct: 656  FSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVF 712

Query: 877  ERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTR 935
            +   YT  V ED P  + +  + A  E    +  I Y +   D   +F I    G + T+
Sbjct: 713  QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDADTGAVTTQ 770

Query: 936  KPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
              LD+E Q    L + A+    P  S T  + I V DVNDN P FLR S +  + +  PP
Sbjct: 771  AELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP 830

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGV--FAIDRALGVLFLNGSLGAGEQRELTLT 1052
             T++    A DRDSG NG + Y+      G   F ++   G++     L      +  L 
Sbjct: 831  FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLR 890

Query: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112
              A D+G+ P    + +TV +     +P   FE   + V V E+ SP+   +        
Sbjct: 891  AYAVDKGMPPARTPMEVTVTVLDVNDNPP-VFEQDEFDVFVEEN-SPIGLAVARVTATDP 948

Query: 1113 PQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQN 1172
             +   + + Y +       +F +  ++G +      DYE    Y   + A          
Sbjct: 949  DEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAP-----L 1003

Query: 1173 VS-TTVIVRVWDENDNSPTFLH-DVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227
            VS  TV VR+ D NDN P   + ++LF   +    S  P G IG++ A D D   +    
Sbjct: 1004 VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYS 1063

Query: 1228 YFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
            +   ++     +N +TGEL    ALD        M+VLV+D
Sbjct: 1064 FERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104



 Score =  313 bits (803), Expect = 6e-85
 Identities = 317/1095 (28%), Positives = 473/1095 (43%), Gaps = 135/1095 (12%)

Query: 21   KLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPD 80
            KL   PG R        S G R +R++            +    Q  +   +V E  P  
Sbjct: 149  KLAQAPGLRAGERSPEESLGGRRKRNV-----------NTAPQFQPPSYQATVPENQPAG 197

Query: 81   TLVGDIRAGLPAAQQQEGSGFFLSEDSD---DSPLLDDFHVHPDTGIIRTARRLDRERRD 137
            T V  +RA  P     EG    L    D   DS     F + P TG + TA  LDRE + 
Sbjct: 198  TPVASLRAIDP----DEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKS 253

Query: 138  HYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVA 191
             + F V A   G     A+  + I V D NDH P F     +  + E    G       A
Sbjct: 254  THVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRA 313

Query: 192  HDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLL 251
             D DA   +   Y L++ S                  G  PS +       ++P   V+ 
Sbjct: 314  TDGDAPPNANILYRLLEGS------------------GGSPSEVF-----EIDPRSGVIR 350

Query: 252  RR--LDREEAAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
             R  +DREE  +++L +EA D GR   PR T   +V L V D+NDN P F +  Y   VR
Sbjct: 351  TRGPVDREEVESYQLTVEASDQGRDPGPRST-TAAVFLSVEDDNDNAPQFSEKRYVVQVR 409

Query: 307  EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
            ED  PGA V RV A+DRD G N  V YS+ +         G A G    F ++  +G + 
Sbjct: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMS---------GNARGQ---FYLDAQTGALD 457

Query: 367  VWRPLDREAQAWHQLVVEARDGGAEP-EVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425
            V  PLD E    + L V A+DGG  P    +  V++ VLD+NDN P    +F++    A 
Sbjct: 458  VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAP----IFVSTPFQAT 513

Query: 426  VSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS-ISLSLEGGEGDFALLPGG 484
            V E    G  V  V   DAD                 GD + +   L G   DF      
Sbjct: 514  VLESVPLGYLVLHVQAIDADA----------------GDNARLEYRLAGVGHDFPFTINN 557

Query: 485  PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544
              G  ++ V   LDRE  D Y   + A D G+P L+   ++ + V D+ND  P F+Q  Y
Sbjct: 558  --GTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEY 615

Query: 545  KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604
               ++E AA GT V+ VSA D D     H+ + Y +         G+ +++   T++ G 
Sbjct: 616  TVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITS-------GNTRNRFSITSQSG- 663

Query: 605  SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
                    G +S    LD +++    L V A D G    +A  +V++T  D N + P+F 
Sbjct: 664  -------GGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVT--DANTHRPVFQ 713

Query: 665  RQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI 724
               Y   + E  P G   + ++A+D D+G    I Y     F+    PQ FRID   G +
Sbjct: 714  SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-----FMEDSIPQ-FRIDADTGAV 767

Query: 725  CVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
                ++D E D  +Y L + A+D G    S   ++ + + DVNDN P F   +Y  S+ +
Sbjct: 768  TTQAELDYE-DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826

Query: 783  ETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGIIYLTLPLSHLESTT 841
            +  P T ++ + ATD+DSG+ G V Y    G +    F ++ST+GI+     L       
Sbjct: 827  DVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQ 886

Query: 842  LSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR 901
              L   A D G   A    +VT+ +      P  FE+ ++   V E+ P    +  V A 
Sbjct: 887  YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTAT 946

Query: 902  EP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960
            +P   ++  I Y+I  G++   F +    G +     LD+E +P  VL +QA   SAP  
Sbjct: 947  DPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT--SAPLV 1004

Query: 961  SSTEVNITVMDVNDNHPAF----LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRY 1016
            S   V++ ++D NDN P      +  ++ +    ++ PG A+    A D D   +  + Y
Sbjct: 1005 SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTY 1062

Query: 1017 SI-ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH---PQAALLVLTVV 1072
            S     +  +  ++ + G L L+ +L      E  +++   D GVH    Q AL V  + 
Sbjct: 1063 SFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIIT 1121

Query: 1073 IEKREHSPSWTFEHL 1087
             E   HS +   E +
Sbjct: 1122 DEMLTHSITLRLEDM 1136



 Score =  306 bits (785), Expect = 7e-83
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 520  STEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579
            S EE+L  R     +  P F    Y+A+V E    GT V  + A D DE  +    L YT
Sbjct: 162  SPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGR--LEYT 219

Query: 580  VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG 639
            +  L                +     F++D  +GA++T   LDRE +     +V AQD G
Sbjct: 220  MDAL--------------FDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHG 265

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
             P  SA   ++I V D ND++P+F +Q Y  ++ E+  VG+  L V A+D D+     I 
Sbjct: 266  MPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANIL 325

Query: 700  YSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLVEA----KDGGGLSAQ 754
            Y L +G  S  +P + F IDP  G I     +DRE +  +Y L VEA    +D G  S  
Sbjct: 326  YRLLEG--SGGSPSEVFEIDPRSGVIRTRGPVDRE-EVESYQLTVEASDQGRDPGPRSTT 382

Query: 755  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 814
            A V + +ED NDN P F+   YV  + ++  PG  ++ V A+D+D G    V Y ++ GN
Sbjct: 383  AAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN 442

Query: 815  VSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLT-AVINADVTIHIFQTTLAP 873
                F +D+ TG + +  PL +  +   +L V AQDGG    + ++  VT+ +       
Sbjct: 443  ARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502

Query: 874  AEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTI 932
              F    +   V E VP    +  V+A +     +  + YR++       F+I+   G I
Sbjct: 503  PIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWI 562

Query: 933  RTRKPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQT 991
                 LD E        V+A+    PA + S  V++TV+DVNDN+P F +    +R+++ 
Sbjct: 563  SVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED 622

Query: 992  TPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALG--VLFLNGSLGAGEQRE 1048
               GT++    A DRD+  + +I Y I S      F+I    G  ++ L   L    +R+
Sbjct: 623  AAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ 680

Query: 1049 LTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
              L + A D G     A +V+ V  +   H P +   H  Y V V+E     T ++   A
Sbjct: 681  YVLAVTASD-GTRQDTAQIVVNVT-DANTHRPVFQSSH--YTVNVNEDRPAGTTVVLISA 736

Query: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
                    A  + Y +E S+    F I   TG +  + + DYE   +Y   + A   ++G
Sbjct: 737  TDEDTGENAR-ITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITA--RDNG 791

Query: 1169 FLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 1227
              Q   TT + + V D NDN+P FL D     V E   P   + +I+A D DSG NG++ 
Sbjct: 792  IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVF 851

Query: 1228 YFLLS----DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283
            Y        DG F  +   +G +     LDRE+   + +     D+G PP    M V V+
Sbjct: 852  YTFQGGDDGDGDFI-VESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVT 910

Query: 1284 VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            V D+NDN P F Q     E  V V E  P+ + V  V A DPDEG NA++ Y +
Sbjct: 911  VLDVNDNPPVFEQ----DEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI 960



 Score =  285 bits (728), Expect = 3e-76
 Identities = 240/809 (29%), Positives = 365/809 (45%), Gaps = 47/809 (5%)

Query: 497  LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556
            LDRE++  +   + A D G P  S   TL + V D ND  P+F QQ YK S+ E    G 
Sbjct: 247  LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306

Query: 557  VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS--FAIDSESGA 614
             V+ V A+D D                 AP N   L  +++  +   PS  F ID  SG 
Sbjct: 307  EVLTVRATDGD-----------------APPNANILY-RLLEGSGGSPSEVFEIDPRSGV 348

Query: 615  ISTIRTLDREVQEAVELKVVAQDLGEPP--LSATCLVSITVDDVNDNEPIFWRQVYNATI 672
            I T   +DRE  E+ +L V A D G  P   S T  V ++V+D NDN P F  + Y   +
Sbjct: 349  IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408

Query: 673  AEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 732
             E    G   L+VTASD D G    + YS+  G     A   F +D   G + V   +D 
Sbjct: 409  REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSG----NARGQFYLDAQTGALDVVSPLDY 464

Query: 733  ERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 789
            E     Y L V A+DGG     +    V V + D+NDN P+F  + +  ++ +    G  
Sbjct: 465  ETTKE-YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523

Query: 790  IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQ 849
            +++V A D D+G    + Y L        FTI++ TG I +   L   E    S  V A+
Sbjct: 524  VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583

Query: 850  DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP 909
            D G      +A V++ +         F +P+YT  + ED    + + TV A +  ++   
Sbjct: 584  DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDR-DAHSV 642

Query: 910  IFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNI 967
            I Y+I+SG+   +FSI  + G   +    PLD++ +   VL V A  G+    +   VN+
Sbjct: 643  ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNV 702

Query: 968  TVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFA 1027
            T  D N + P F  +   + +++  P GT + L  A D D+G N  I Y +    P  F 
Sbjct: 703  T--DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ-FR 759

Query: 1028 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEH 1086
            ID   G +     L   +Q   TL + A D G+  ++    L +++ +  +++P +  + 
Sbjct: 760  IDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDS 819

Query: 1087 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDS-AMFGIRPYTGWIYLR 1145
              YQ  V E + P T +LQ  A           + Y+ +   D    F +   +G +   
Sbjct: 820  --YQGSVYEDVPPFTSVLQISATDRD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876

Query: 1146 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 1205
            R+ D E+   Y  R +A + +          V V V D NDN P F  D   + VEE+  
Sbjct: 877  RRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSP 935

Query: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMT 1263
                + ++TA D D G N Q++Y ++     + F+++  +GEL   V LD E R  +   
Sbjct: 936  IGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY--- 992

Query: 1264 VLVTDRGSPPRNATMAVYVSVTDINDNRP 1292
            VLV    S P  +   V+V + D NDN P
Sbjct: 993  VLVIQATSAPLVSRATVHVRLLDRNDNPP 1021



 Score =  255 bits (651), Expect = 2e-67
 Identities = 251/953 (26%), Positives = 393/953 (41%), Gaps = 122/953 (12%)

Query: 103  LSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLG-------AVVQVE 154
            L E S  SP  + F + P +G+IRT   +DRE  + Y   V A+  G           V 
Sbjct: 328  LLEGSGGSPS-EVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVF 386

Query: 155  IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
            + V D ND++P+F      + V E   PG       A D D G  +   Y+++  +    
Sbjct: 387  LSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---- 442

Query: 215  DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
              A   F L  +T          G+   + PLD         E    + L++ A DGGRP
Sbjct: 443  --ARGQFYLDAQT----------GALDVVSPLDY--------ETTKEYTLRVRAQDGGRP 482

Query: 275  RRTGLLS-VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
              + +   V ++VLD NDN P+F    ++A V E    G  V  V+A D D G N  + Y
Sbjct: 483  PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY 542

Query: 334  SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
             +              +G    F +   +G + V   LDRE   ++   VEARD G    
Sbjct: 543  RL------------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590

Query: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
             A+  VS+ VLDVNDN P     F       R++E A  G  V  VS  D D        
Sbjct: 591  TASASVSVTVLDVNDNNPT----FTQPEYTVRLNEDAAVGTSVVTVSAVDRDA----HSV 642

Query: 454  ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             T ++  G      S++ + G G  +L               PLD +    Y L + A+D
Sbjct: 643  ITYQITSGNTRNRFSITSQSGGGLVSLAL-------------PLDYKLERQYVLAVTASD 689

Query: 514  AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
                  +    +++ V D N   P+F   HY  +V+E    GT V+ +SA+D D    ++
Sbjct: 690  GTRQDTAQ---IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--EN 744

Query: 574  AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
            A + Y +                    +  P F ID+++GA++T   LD E Q +  L +
Sbjct: 745  ARITYFM-------------------EDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAI 785

Query: 634  VAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG 693
             A+D G P  S T  + I V+DVNDN P F R  Y  ++ E  P     LQ++A+D DSG
Sbjct: 786  TARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSG 845

Query: 694  LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSA 753
            L G + Y+   G    +    F ++   G +   + +DRE + A Y L   A D G   A
Sbjct: 846  LNGRVFYTFQGG---DDGDGDFIVESTSGIVRTLRRLDRE-NVAQYVLRAYAVDKGMPPA 901

Query: 754  QA--FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 811
            +    V V + DVNDN PVF    +   + + +  G  +  V ATD D G    + Y+++
Sbjct: 902  RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961

Query: 812  PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL 871
             GN+  +F +D  +G +   + L + +     L++ A        V  A V + +     
Sbjct: 962  EGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRND 1018

Query: 872  APAEFERPKYTFLVYEDVPEDS----PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
             P      +  F  Y      S     IG V A +P + S+ + Y    G+      ++ 
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDP-DISDSLTYSFERGNELSLVLLNA 1077

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVM-DVNDNHPAFLRTSD-- 984
              G ++  + LD+      +++V    G     +   + +T++ D    H   LR  D  
Sbjct: 1078 STGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMS 1137

Query: 985  --------------EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
                           +  +  TPP   +      D D+    ++  S++  QP
Sbjct: 1138 PERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQP 1190



 Score =  186 bits (473), Expect = 1e-46
 Identities = 168/592 (28%), Positives = 258/592 (43%), Gaps = 32/592 (5%)

Query: 769  PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTT 825
            P F P +Y  ++ +    GT + ++ A D D G  G + Y    L     +  F++D  T
Sbjct: 179  PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238

Query: 826  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
            G +     L     +T    V+AQD G       A +TI +  T      FE+ +Y   +
Sbjct: 239  GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298

Query: 886  YEDVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTRKPLD 939
             E++     + TV+A +   P N++  I YR+  G  G     F I PR G IRTR P+D
Sbjct: 299  RENLEVGYEVLTVRATDGDAPPNAN--ILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356

Query: 940  HETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
             E      LTV+A        P  ++  V ++V D NDN P F      +++ +   PG 
Sbjct: 357  REEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGA 416

Query: 997  ALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRA 1055
             +    A DRD G N ++ YSI S    G F +D   G L +   L     +E TL +RA
Sbjct: 417  PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRA 476

Query: 1056 EDQGVHPQAAL--LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
            +D G  P + +  LV   V++  +++P   F    +Q  V ES+     +L  QA     
Sbjct: 477  QDGGRPPLSNVSGLVTVQVLDINDNAP--IFVSTPFQATVLESVPLGYLVLHVQAIDADA 534

Query: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
               A  L Y L        F I   TGWI +  + D E    Y+F V A       L   
Sbjct: 535  GDNAR-LEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL-TA 592

Query: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
            S +V V V D NDN+PTF      +++ E       +  ++A+D D+     ++ + ++ 
Sbjct: 593  SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS---VITYQITS 649

Query: 1234 GKF---FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
            G     F +   +G  +  +AL  +++   +  + VT      R  T  + V+VTD N +
Sbjct: 650  GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT-ASDGTRQDTAQIVVNVTDANTH 708

Query: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
            RP F          V V E +P    V  + A D D G NA +TY +  + P
Sbjct: 709  RPVFQS----SHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP 756


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score =  326 bits (835), Expect = 1e-88
 Identities = 247/766 (32%), Positives = 376/766 (49%), Gaps = 57/766 (7%)

Query: 606  FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
            F IDS +GA+ST   LDRE +E   L+V A D   PP SAT  +++ V D ND+ P+F +
Sbjct: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355

Query: 666  QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQIC 725
              Y   + E+  VG+  L + ASD DS +   + Y +  G     A   F+++   G + 
Sbjct: 356  SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-----AWDVFQLNESSGVVS 410

Query: 726  VSQDIDRERDPATYDLLVEAKDGGG----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 781
                +DRE + A Y LLVEA D G     LSA A V +++ED NDN+P F+   YV  + 
Sbjct: 411  TRAVLDRE-EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVP 469

Query: 782  DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTT 841
            ++    T ++ V ATD+D G    + Y ++ GNV+  F + S +GI+ +  PL   +   
Sbjct: 470  EDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529

Query: 842  LSLMVSAQDGGGLTAVINAD--VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 899
             SL + AQD GG   +IN+   V++ +         F    +   V E+VP   P+  ++
Sbjct: 530  YSLSIKAQD-GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ 588

Query: 900  ARE-PLNSSEPIFYRI---SSGDLGG--------------KFSIHPRLGTIRTRKPLDHE 941
            A +     +  + YR+   +S  LGG               F IH   G I     LD E
Sbjct: 589  AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648

Query: 942  TQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 1000
                    V+A   GS P  SST V+ITV+DVNDN P F + + E+R+++    G+++  
Sbjct: 649  EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708

Query: 1001 ARAEDRDSGRNGLIRYSIASPQP-GVFAI--DRALGVLFLNGSLGAGEQRELTLTLRAED 1057
             +A DRD+  N +I Y +        FA+   R  G++ L   L   ++++  L + A D
Sbjct: 709  LQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766

Query: 1058 QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 1117
             G     A +++ V  +   H P +   H  Y V VSE     T +    A+       A
Sbjct: 767  -GTRSHTAHVLINVT-DANTHRPVFQSSH--YTVSVSEDRPVGTSIATLSANDEDTGENA 822

Query: 1118 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTV 1177
              + Y ++  V    F I P +G +Y   + DYE+   Y   + A   ++G  Q   TT 
Sbjct: 823  R-ITYVIQDPV--PQFRIDPDSGTMYTMMELDYENQVAYTLTIMA--QDNGIPQKSDTTT 877

Query: 1178 I-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL----S 1232
            + + + D NDN+P FL D     + E   P   I +++A D DSG NG+LLY        
Sbjct: 878  LEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG 937

Query: 1233 DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTDINDNR 1291
            DG F+ + P +G +     LDRE+   + +  L  DRGSP P +A++ + V++ DINDN 
Sbjct: 938  DGDFY-IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            P F +     EL + V E  PV  +V  + A DPDEG NA++ Y +
Sbjct: 997  PMFEK----DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQI 1038



 Score =  309 bits (791), Expect = 1e-83
 Identities = 280/914 (30%), Positives = 404/914 (44%), Gaps = 75/914 (8%)

Query: 254  LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGA 313
            LDRE    H L+++A D   P R+    + + V D ND+ PVFEQ EYR  VRE+ + G 
Sbjct: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370

Query: 314  EVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDR 373
            EV  +RA+DRD   N  +RY V           GGA      F + E SGVV     LDR
Sbjct: 371  EVLTIRASDRDSPINANLRYRVL----------GGAWD---VFQLNESSGVVSTRAVLDR 417

Query: 374  EAQAWHQLVVEARDGGAEPE--VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGAR 431
            E  A +QL+VEA D G  P    AT  V I V D NDN P     F  +  V +V E   
Sbjct: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQ----FSEQNYVVQVPEDVG 473

Query: 432  PGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFF- 490
                V RV  +D D                          +     +++L G   G F+ 
Sbjct: 474  LNTAVLRVQATDRDQG------------------------QNAAIHYSILSGNVAGQFYL 509

Query: 491  ------LCVEGPLDRESRDLYELLLVATDAGSPPL-STEETLLLRVADLNDQPPLFSQQH 543
                  L V  PLD E    Y L + A D G PPL ++   + ++V D+ND  P+F    
Sbjct: 510  HSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSP 569

Query: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
            ++A+V E    G  V+ + A DAD    ++A L Y +V  ++    G             
Sbjct: 570  FQATVLENVPLGYPVVHIQAVDAD--SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPD 627

Query: 604  PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
              F I + SG I+    LDRE  E     V A D G PP+S++  VSITV DVNDN+P+F
Sbjct: 628  FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF 687

Query: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723
             +  Y   + E A VG   L + A D D+     I Y L  G  +     A       G 
Sbjct: 688  TQPTYELRLNEDAAVGSSVLTLQARDRDAN--SVITYQLTGG--NTRNRFALSSQRGGGL 743

Query: 724  ICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDE 783
            I ++  +D +++   Y L V A D G  S  A V +++ D N + PVF  S Y  S+S++
Sbjct: 744  ITLALPLDYKQE-QQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSED 801

Query: 784  TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLS 843
               GT I  + A D+D+G    + Y +I   V   F ID  +G +Y  + L +      +
Sbjct: 802  RPVGTSIATLSANDEDTGENARITY-VIQDPVPQ-FRIDPDSGTMYTMMELDYENQVAYT 859

Query: 844  LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP 903
            L + AQD G         + I I        +F    Y   ++ED P  + I  V A + 
Sbjct: 860  LTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATD- 918

Query: 904  LNSSEP---IFYRISSGDLG-GKFSIHPRLGTIRTRKPLDHETQPVVVL-TVQAQLGS-A 957
               S P   + Y    GD G G F I P  G IRT++ LD E   V  L  +    GS  
Sbjct: 919  -RDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPT 977

Query: 958  PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 1017
            P  +S E+ +T++D+NDN P F +   E+ + +  P G+ +   RA D D G N  I Y 
Sbjct: 978  PLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037

Query: 1018 IA-SPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKR 1076
            I        F +D   G L     L    +RE  L ++A    +  +A + +L  ++++ 
Sbjct: 1038 IVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHIL--LVDQN 1095

Query: 1077 EHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGI 1135
            ++ P    F+ L      ++S S  T ++     P      +  L Y+     +  +  +
Sbjct: 1096 DNPPVLPDFQILFNNYVTNKSNSFPTGVI--GCIPAHDPDVSDSLNYTFVQGNELRLLLL 1153

Query: 1136 RPYTGWIYLRRQFD 1149
             P TG + L R  D
Sbjct: 1154 DPATGELQLSRDLD 1167



 Score =  292 bits (748), Expect = 1e-78
 Identities = 293/1028 (28%), Positives = 437/1028 (42%), Gaps = 101/1028 (9%)

Query: 68   NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127
            N  +++ E  P  TL+  + A      ++E   +++ E   D      F +   TG + T
Sbjct: 249  NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGYFRIDSATGAVST 307

Query: 128  ARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
               LDRE ++ +      +        A   + + V D NDHSP F     +  V E   
Sbjct: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367

Query: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
             G       A D D+ + +                      LRYR  G          SS
Sbjct: 368  VGYEVLTIRASDRDSPINA---------------------NLRYRVLGGAWDVFQLNESS 406

Query: 242  PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS----VELRVLDENDNPPVFE 297
             +     V    LDREEAA ++L +EA D G  R  G LS    V + V DENDN P F 
Sbjct: 407  GVVSTRAV----LDREEAAEYQLLVEANDQG--RNPGPLSATATVYIEVEDENDNYPQFS 460

Query: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357
            +  Y   V ED      V RV+ATDRD G N  + YS+ +  V G             F 
Sbjct: 461  EQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAG------------QFY 508

Query: 358  VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV-ATVRVSIAVLDVNDNRPAIHVL 416
            +  LSG++ V  PLD E    + L ++A+DGG  P + ++  VS+ VLDVNDN P    +
Sbjct: 509  LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEP----I 564

Query: 417  FLTEGGVARVSEGARPGDYVARVSVSDADG--DWEKEDEATGELGVGLGDGSISLSLEGG 474
            F++    A V E    G  V  +   DAD   +              LG GS        
Sbjct: 565  FVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAP 624

Query: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
              DF        G   +C E  LDRE  + Y   + A D GSPP+S+  ++ + V D+ND
Sbjct: 625  TPDFPFQIHNSSGWITVCAE--LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVND 682

Query: 535  QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
              P+F+Q  Y+  ++E AA G+ V+ + A D D     ++ + Y   QL+     G+ ++
Sbjct: 683  NDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA----NSVITY---QLTG----GNTRN 731

Query: 595  KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
            +   +++ G         G I+    LD + ++   L V A D      S T  V I V 
Sbjct: 732  RFALSSQRG--------GGLITLALPLDYKQEQQYVLAVTASD---GTRSHTAHVLINVT 780

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
            D N + P+F    Y  +++E  PVG     ++A+D D+G    I Y + D       PQ 
Sbjct: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-----PVPQ- 834

Query: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772
            FRIDP  G +    ++D E   A Y L + A+D G    S    + + + D NDN P F 
Sbjct: 835  FRIDPDSGTMYTMMELDYENQVA-YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGIIYLT 831
               Y  SI ++  P T I+ V ATD+DSG  G + Y    G +    F I+ T+G+I   
Sbjct: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953

Query: 832  LPLSHLESTTLSLMVSAQDGGGLTAV-INADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 890
              L        +L   A D G  T +  + ++ + I         FE+ +    V E+ P
Sbjct: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013

Query: 891  EDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
              S +  ++A +P    +  I Y+I  GD+   F +    G +R    LD E +   VL 
Sbjct: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073

Query: 950  VQAQLGSAPACSSTEVNITVMDVNDNHPAF----LRTSDEIRISQTTPPGTALYLARAED 1005
            VQA   SAP  S   V+I ++D NDN P      +  ++ +     + P   +    A D
Sbjct: 1074 VQAT--SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHD 1131

Query: 1006 RDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAA 1065
             D   + L    +   +  +  +D A G L L+  L      E  + +   D G+H   A
Sbjct: 1132 PDVS-DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTA 1189

Query: 1066 LLVLTVVI 1073
               L V I
Sbjct: 1190 FCTLRVTI 1197



 Score =  291 bits (745), Expect = 3e-78
 Identities = 250/870 (28%), Positives = 389/870 (44%), Gaps = 69/870 (7%)

Query: 497  LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556
            LDRE+++ + L + A D  +PP S    + + V D ND  P+F Q  Y+  V E    G 
Sbjct: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370

Query: 557  VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIS 616
             V+ + ASD D     +A LRY V+                        F ++  SG +S
Sbjct: 371  EVLTIRASDRDSP--INANLRYRVL------------------GGAWDVFQLNESSGVVS 410

Query: 617  TIRTLDREVQEAVELKVVAQDLGEPP--LSATCLVSITVDDVNDNEPIFWRQVYNATIAE 674
            T   LDRE     +L V A D G  P  LSAT  V I V+D NDN P F  Q Y   + E
Sbjct: 411  TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE 470

Query: 675  HAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER 734
               +    L+V A+D D G    I YS+  G ++ +    F +    G + V   +D E 
Sbjct: 471  DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ----FYLHSLSGILDVINPLDFE- 525

Query: 735  DPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791
            D   Y L ++A+DGG    +++   V V + DVNDN P+F  S +  ++ +    G  ++
Sbjct: 526  DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV 585

Query: 792  NVLATDQDSGIYGTVAYELI-------------PGNVSSL----FTIDSTTGIIYLTLPL 834
            ++ A D DSG    + Y L+             P N +      F I +++G I +   L
Sbjct: 586  HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAEL 645

Query: 835  SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSP 894
               E    S  V A D G      +  V+I +         F +P Y   + ED    S 
Sbjct: 646  DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS 705

Query: 895  IGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLTVQA 952
            + T++AR+  +++  I Y+++ G+   +F++  + G   I    PLD++ +   VL V A
Sbjct: 706  VLTLQARDR-DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTA 764

Query: 953  QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012
              G+    +   +N+T  D N + P F  +   + +S+  P GT++    A D D+G N 
Sbjct: 765  SDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENA 822

Query: 1013 LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV 1072
             I Y I  P P  F ID   G ++    L    Q   TLT+ A+D G+  ++    L ++
Sbjct: 823  RITYVIQDPVPQ-FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881

Query: 1073 I-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP---LRYSLEPSV 1128
            I +  +++P + ++   YQ  + E   P T +LQ  A      R + P   L Y+ +   
Sbjct: 882  ILDANDNAPQFLWDF--YQGSIFEDAPPSTSILQVSA----TDRDSGPNGRLLYTFQGGD 935

Query: 1129 DS-AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDN 1187
            D    F I P +G I  +R+ D E+   YN    A         + S  + V + D NDN
Sbjct: 936  DGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDN 995

Query: 1188 SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGE 1245
            +P F  D L L VEE+     V+ KI A D D G N Q++Y ++      FF+++   G+
Sbjct: 996  APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD 1055

Query: 1246 LINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV 1305
            L   V LD E R  +   VLV    S P  +   V++ + D NDN P  P        +V
Sbjct: 1056 LRAMVELDFEVRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112

Query: 1306 KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
                      ++  + A DPD  ++   T+
Sbjct: 1113 TNKSNSFPTGVIGCIPAHDPDVSDSLNYTF 1142



 Score =  290 bits (741), Expect = 9e-78
 Identities = 316/1123 (28%), Positives = 467/1123 (41%), Gaps = 129/1123 (11%)

Query: 197  GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLD- 255
            G  + Q   L  P+ LP            R P P P P  PG    L P   V LR L  
Sbjct: 138  GCAAAQHSALAAPTTLPA----------CRCP-PRPRPRCPGRPICLPPGGSVRLRLLCA 186

Query: 256  -REEAAAHR--LQIEAWDGGRPRRTGLLSVELRV-LDENDNPPV--------------FE 297
             R  A A R  L +EA   G P  +   S  L   L E    P               F 
Sbjct: 187  LRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFP 246

Query: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA--Y 355
               Y+ A+ E+   G  + ++ A     G    V Y +            G   + +  Y
Sbjct: 247  MPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----------GLFDERSRGY 295

Query: 356  FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
            F ++  +G V     LDRE +  H L V+A D    P  AT  +++ V D ND+ P    
Sbjct: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355

Query: 416  LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGE 475
                E    RV E    G  V  +  SD D                  + ++   + GG 
Sbjct: 356  SEYRE----RVRENLEVGYEVLTIRASDRDSPI---------------NANLRYRVLGGA 396

Query: 476  GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG--SPPLSTEETLLLRVADLN 533
             D   L     GV  +     LDRE    Y+LL+ A D G    PLS   T+ + V D N
Sbjct: 397  WDVFQL-NESSGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDEN 453

Query: 534  DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
            D  P FS+Q+Y   V E     T V+ V A+D D+    +A + Y+++            
Sbjct: 454  DNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ--GQNAAIHYSIL------------ 499

Query: 594  SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL-SATCLVSIT 652
                 +      F + S SG +  I  LD E  +   L + AQD G PPL +++ +VS+ 
Sbjct: 500  -----SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQ 554

Query: 653  VDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY--- 709
            V DVNDNEPIF    + AT+ E+ P+G+  + + A DADSG    + Y L D   ++   
Sbjct: 555  VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGG 614

Query: 710  -------EAPQ---AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFV 757
                    AP     F+I    G I V  ++DRE +   Y   VEA D G   +S+   V
Sbjct: 615  GSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE-EVEHYSFGVEAVDHGSPPMSSSTSV 673

Query: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
             + + DVNDN PVF   TY   ++++   G+ ++ + A D+D+     + Y+L  GN  +
Sbjct: 674  SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN--SVITYQLTGGNTRN 731

Query: 818  LFTIDSTT--GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
             F + S    G+I L LPL + +     L V+A DG   T    A V I++         
Sbjct: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPV 788

Query: 876  FERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
            F+   YT  V ED P  + I T+ A  E    +  I Y I   D   +F I P  GT+ T
Sbjct: 789  FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDPDSGTMYT 846

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
               LD+E Q    LT+ AQ    P  S +T + I ++D NDN P FL    +  I +  P
Sbjct: 847  MMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP 906

Query: 994  PGTALYLARAEDRDSGRNGLIRYSI--ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051
            P T++    A DRDSG NG + Y+        G F I+   GV+     L         L
Sbjct: 907  PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNL 966

Query: 1052 TLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109
               A D+G      A++ +   +++  +++P +  + L   VE +  +  +   ++    
Sbjct: 967  WALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDP 1026

Query: 1110 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF 1169
              GP    + + Y +        F +    G +    + D+E  + Y   V A       
Sbjct: 1027 DEGPN---AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA---TSAP 1080

Query: 1170 LQNVSTTVIVRVWDENDNSPTFL-HDVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQ 1225
            L + +T  I+ V D+NDN P      +LF   +  + +  P GVIG I A D D   +  
Sbjct: 1081 LVSRATVHILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139

Query: 1226 LLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
              +   ++ +   ++P TGEL     LD        M V V+D
Sbjct: 1140 YTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182



 Score =  255 bits (652), Expect = 2e-67
 Identities = 253/891 (28%), Positives = 374/891 (41%), Gaps = 112/891 (12%)

Query: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSP 165
            D F ++  +G++ T   LDRE    Y  +            L A   V I V D ND+ P
Sbjct: 398  DVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYP 457

Query: 166  RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
            +F   +  + V E     TA     A D D G  +   Y++     L  + AG F+    
Sbjct: 458  QFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-----LSGNVAGQFY---- 508

Query: 226  RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP---RRTGLLSV 282
                 L S  L G    + PLD         E+   + L I+A DGGRP     +G++SV
Sbjct: 509  -----LHS--LSGILDVINPLDF--------EDVQKYSLSIKAQDGGRPPLINSSGVVSV 553

Query: 283  ELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV--RARQV 340
            +  VLD NDN P+F    ++A V E+   G  V  ++A D D G N  + Y +   A   
Sbjct: 554  Q--VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTF 611

Query: 341  PGAGSGGG---ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV 397
             G GS G    A      F +   SG + V   LDRE    +   VEA D G+ P  ++ 
Sbjct: 612  LGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSST 671

Query: 398  RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
             VSI VLDVNDN P    +F       R++E A  G  V  +   D D +          
Sbjct: 672  SVSITVLDVNDNDP----VFTQPTYELRLNEDAAVGSSVLTLQARDRDAN---------- 717

Query: 458  LGVGLGDGSISLSLEGGE--GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515
                     I+  L GG     FAL      G+  L +  PLD +    Y L + A+D  
Sbjct: 718  -------SVITYQLTGGNTRNRFALSSQRGGGLITLAL--PLDYKQEQQYVLAVTASDGT 768

Query: 516  SPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAW 575
                S    +L+ V D N   P+F   HY  SVSE    GT +  +SA+D D    ++A 
Sbjct: 769  R---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENAR 823

Query: 576  LRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA 635
            + Y +                    +  P F ID +SG + T+  LD E Q A  L ++A
Sbjct: 824  ITYVI-------------------QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864

Query: 636  QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLY 695
            QD G P  S T  + I + D NDN P F    Y  +I E AP     LQV+A+D DSG  
Sbjct: 865  QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924

Query: 696  GFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LS 752
            G + Y+   G    +    F I+P  G I   + +DRE + A Y+L   A D G    LS
Sbjct: 925  GRLLYTFQGG---DDGDGDFYIEPTSGVIRTQRRLDRE-NVAVYNLWALAVDRGSPTPLS 980

Query: 753  AQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIP 812
            A   ++V + D+NDN P+F        + +    G+ +  + A D D G    + Y+++ 
Sbjct: 981  ASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040

Query: 813  GNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLA 872
            G++   F +D   G +   + L         L+V A      +A + +  T+HI      
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-----TSAPLVSRATVHILLVDQN 1095

Query: 873  PAEFERPKYTFLVYEDVPEDS------PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIH 926
                  P +  L    V   S       IG + A +P + S+ + Y    G+      + 
Sbjct: 1096 DNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP-DVSDSLNYTFVQGNELRLLLLD 1154

Query: 927  PRLGTIRTRKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDN 975
            P  G ++  + LD+    + ++ ++V   + S  A  +  V I   D+  N
Sbjct: 1155 PATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTN 1205



 Score =  142 bits (357), Expect = 3e-33
 Identities = 151/604 (25%), Positives = 251/604 (41%), Gaps = 47/604 (7%)

Query: 771  FNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTTGI 827
            F    Y  ++ +    GT I+ + A     G    V+Y    L        F IDS TG 
Sbjct: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304

Query: 828  IYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE 887
            +     L      T  L V A D           +T+ +  T      FE+ +Y   V E
Sbjct: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364

Query: 888  DVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944
            ++     + T++A +   P+N++  + YR+  G     F ++   G + TR  LD E   
Sbjct: 365  NLEVGYEVLTIRASDRDSPINAN--LRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEAA 421

Query: 945  VVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
               L V+A        P  ++  V I V D NDN+P F   +  +++ +     TA+   
Sbjct: 422  EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481

Query: 1002 RAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060
            +A DRD G+N  I YSI S    G F +    G+L +   L   + ++ +L+++A+D G 
Sbjct: 482  QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541

Query: 1061 HP--QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118
             P   ++ +V   V++  ++ P   F    +Q  V E++     ++  QA        A 
Sbjct: 542  PPLINSSGVVSVQVLDVNDNEP--IFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599

Query: 1119 PLRYSLEPSVDSAM-----------------FGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161
             L Y L  +  + +                 F I   +GWI +  + D E  + Y+F V 
Sbjct: 600  -LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658

Query: 1162 AWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSG 1221
            A +       + ST+V + V D NDN P F      L++ E       +  + A D D+ 
Sbjct: 659  A-VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN 717

Query: 1222 KNGQLLYFLLSDGKF---FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
                ++ + L+ G     F ++   G  +  +AL  +++   +  + VT      R+ T 
Sbjct: 718  S---VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT-ASDGTRSHTA 773

Query: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
             V ++VTD N +RP F          V V E +PV   + T+ A D D G NA +TY + 
Sbjct: 774  HVLINVTDANTHRPVFQS----SHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829

Query: 1339 SARP 1342
               P
Sbjct: 830  DPVP 833



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 101/380 (26%), Positives = 159/380 (41%), Gaps = 27/380 (7%)

Query: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS----PQPGVFAIDRALGVLFLNGS 1040
            ++ + +  P GT +    A     G    + Y +         G F ID A G +  +  
Sbjct: 251  QVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSV 310

Query: 1041 LGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP 1099
            L    +    L ++A D    P++A   +TV++ +  +HSP   FE   Y+  V E+L  
Sbjct: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP--VFEQSEYRERVRENLEV 368

Query: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA---MFGIRPYTGWIYLRRQFDYESTQTY 1156
              ++L  +A         SP+  +L   V      +F +   +G +  R   D E    Y
Sbjct: 369  GYEVLTIRASDRD-----SPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423

Query: 1157 NFRVFAWIP--EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKIT 1214
               V A       G L + + TV + V DENDN P F      ++V E       + ++ 
Sbjct: 424  QLLVEANDQGRNPGPL-SATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482

Query: 1215 AIDMDSGKNGQLLYFLLSD---GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGS 1271
            A D D G+N  + Y +LS    G+F+ ++  +G L     LD E    + +++   D G 
Sbjct: 483  ATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541

Query: 1272 PPR-NATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
            PP  N++  V V V D+NDN P F            VLE  P+   V  + A D D G N
Sbjct: 542  PPLINSSGVVSVQVLDVNDNEPIFVS----SPFQATVLENVPLGYPVVHIQAVDADSGEN 597

Query: 1331 AEVTYSVSSARPMPLKGKTA 1350
            A + Y +       L G +A
Sbjct: 598  ARLHYRLVDTASTFLGGGSA 617


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  285 bits (728), Expect = 3e-76
 Identities = 227/736 (30%), Positives = 357/736 (48%), Gaps = 79/736 (10%)

Query: 56  LWAASGSSAQLFNLTLSVDEGLPPDTLVGDI------RAGLPAAQQQEG----SGFFLSE 105
           LWA +     L NL  SV E     T++G+I      + GLP A++  G    SG +   
Sbjct: 11  LWAPA---LTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVL 67

Query: 106 DSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA------VVQVEIRVND 159
           ++    LLD   V  D+G++ T +R+DRE    ++      L        +  +++ + D
Sbjct: 68  ENSAPHLLD---VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQD 124

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P F  D +++D+SE + PGT F L  AHDPDAG    + Y L       +D  G 
Sbjct: 125 INDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLT------RDDHG- 177

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  ++ G        G+  P    +LV+ + LDRE+   H L + A DGG P R+  
Sbjct: 178 LFGLDVKSRGD-------GTKFP----ELVIQKALDREQQNHHTLVLTALDGGEPPRSAT 226

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
           + + ++V+D NDN PVFE   Y   + E+A  G  V  + ATD D GPNG V YS  +  
Sbjct: 227 VQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSF-SSY 285

Query: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
           VP              F+++  +G++RV   LD E     ++ V+ARD G  P  A  +V
Sbjct: 286 VPDR--------VRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKV 337

Query: 400 SIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELG 459
           ++ ++D NDN P+I  + + +G    +SE A PG  +A V V+D D     + +     G
Sbjct: 338 TVKLIDRNDNAPSIGFVSVRQGA---LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGG 394

Query: 460 VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
            G G G   L   GG   F  L       + +  + PLDRE++D Y + +VA D GSPPL
Sbjct: 395 GGTGGGG-GLGGPGGSVPFK-LEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPL 452

Query: 520 STEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579
           ++ ++  +++ D ND PP F++  Y   V E   PG  +  V A D D     +  + Y+
Sbjct: 453 NSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDL--GQNGTVSYS 510

Query: 580 VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG 639
           ++    P ++G +    ++T       +++  +GAI  +R+ + E  +A E KV+A+D G
Sbjct: 511 IL----PSHIGDVS---IYT-----YVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSG 558

Query: 640 EPP-LSATCLVSITVDDVNDNEPIFWRQVYNATIAE-----HAPVGHCFLQVTASDADSG 693
            P  L +   V +TV DVNDN P+          AE     +A +G+    V A D+D G
Sbjct: 559 APAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFG 618

Query: 694 LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSA 753
             G + Y + DG         F IDP  G+I        +  P   +L+V+  D G  + 
Sbjct: 619 ESGRLTYEIVDG----NDDHLFEIDPSSGEIRTLHPFWEDVTPVV-ELVVKVTDHGKPTL 673

Query: 754 QAFVRVDLEDVNDNHP 769
            A  ++ +  V+ + P
Sbjct: 674 SAVAKLIIRSVSGSLP 689



 Score =  194 bits (492), Expect = 6e-49
 Identities = 173/630 (27%), Positives = 266/630 (42%), Gaps = 77/630 (12%)

Query: 252 RRLDREEAAAH----RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
           +R+DRE    H    +L +E +   +     +  +++ + D NDN P F  D+    + E
Sbjct: 88  QRIDRESLCRHNAKCQLSLEVFANDKE----ICMIKVEIQDINDNAPSFSSDQIEMDISE 143

Query: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
           +A PG       A D D G NG   Y +        G    + GD   F        + +
Sbjct: 144 NAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE------LVI 197

Query: 368 WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
            + LDRE Q  H LV+ A DGG  P  ATV++++ V+D NDN P    +F     +  + 
Sbjct: 198 QKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSP----VFEAPSYLVELP 253

Query: 428 EGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPP 486
           E A  G  V  ++ +DAD                  +G +  S      D    L    P
Sbjct: 254 ENAPLGTVVIDLNATDADEG---------------PNGEVLYSFSSYVPDRVRELFSIDP 298

Query: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYK- 545
               + V+G LD E   + E+ + A D G  P+     + +++ D ND  P       + 
Sbjct: 299 KTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQ 358

Query: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
            ++SEAA PGTV+  V  +D D   +                  G LQ +++     G  
Sbjct: 359 GALSEAAPPGTVIALVRVTDRDSGKN------------------GQLQCRVLGGGGTGGG 400

Query: 606 FAIDSESGAIS--------------TIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
             +    G++               T R LDRE Q+   + +VA+D G PPL++T   +I
Sbjct: 401 GGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAI 460

Query: 652 TVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
            + D NDN P F + +Y   + E+   G     V A D D G  G + YS+    +   +
Sbjct: 461 KILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVS 520

Query: 712 PQAF-RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDN 767
              +  ++P +G I   +  + E+  A ++  V AKD G    L + A VRV + DVNDN
Sbjct: 521 IYTYVSVNPTNGAIYALRSFNFEQTKA-FEFKVLAKDSGAPAHLESNATVRVTVLDVNDN 579

Query: 768 HPVFNPSTYVTSISDETQP-----GTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 822
            PV    T     ++   P     G  +  V A D D G  G + YE++ GN   LF ID
Sbjct: 580 APVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEID 639

Query: 823 STTGIIYLTLPLSHLESTTLSLMVSAQDGG 852
            ++G I    P     +  + L+V   D G
Sbjct: 640 PSSGEIRTLHPFWEDVTPVVELVVKVTDHG 669



 Score =  177 bits (448), Expect = 8e-44
 Identities = 178/666 (26%), Positives = 284/666 (42%), Gaps = 84/666 (12%)

Query: 341 PGAGSGGGALGDAAYFAVEEL----------SGVVRVWRPLDREAQAWH----QLVVEAR 386
           P    GGG     +Y  +E            SG++   + +DRE+   H    QL +E  
Sbjct: 50  PAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVF 109

Query: 387 DGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADG 446
               + E+  ++V I   D+NDN P+    F ++     +SE A PG      S  D D 
Sbjct: 110 AN--DKEICMIKVEIQ--DINDNAPS----FSSDQIEMDISENAAPGTRFPLTSAHDPDA 161

Query: 447 DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE 506
               E+     L      G   L ++   GD    P        L ++  LDRE ++ + 
Sbjct: 162 G---ENGLRTYLLTRDDHGLFGLDVKS-RGDGTKFPE-------LVIQKALDREQQNHHT 210

Query: 507 LLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDA 566
           L+L A D G PP S    + ++V D ND  P+F    Y   + E A  GTVV+ ++A+DA
Sbjct: 211 LVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDA 270

Query: 567 DEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQ 626
           DE  +      ++      P  +  L             F+ID ++G I     LD E  
Sbjct: 271 DEGPNGEVLYSFSSY---VPDRVREL-------------FSIDPKTGLIRVKGNLDYEEN 314

Query: 627 EAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP-IFWRQVYNATIAEHAPVGHCFLQV 685
             +E+ V A+DLG  P+ A C V++ + D NDN P I +  V    ++E AP G     V
Sbjct: 315 GMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALV 374

Query: 686 TASDADSGLYGFIEYSLYDG--------FLSYEAPQAFRIDPHDGQ---ICVSQDIDRER 734
             +D DSG  G ++  +  G                 F+++ +      +   + +DRE 
Sbjct: 375 RVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRET 434

Query: 735 DPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 792
               Y++ + A+DGG   L++     + + D NDN P F    YV  + +   PG  + +
Sbjct: 435 QDE-YNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGS 493

Query: 793 VLATDQDSGIYGTVAYELIPGNVS--SLFT---IDSTTGIIYLTLPLSHLESTTLSLMVS 847
           VLA D D G  GTV+Y ++P ++   S++T   ++ T G IY     +  ++      V 
Sbjct: 494 VLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVL 553

Query: 848 AQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED------VPEDSPIG----T 897
           A+D G   A + ++ T+ +   T+       P       ++      VP ++ +G    T
Sbjct: 554 AKDSGA-PAHLESNATVRV---TVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVST 609

Query: 898 VKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGS 956
           V+A +     S  + Y I  G+    F I P  G IRT  P   +  PVV L V+     
Sbjct: 610 VRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHG 669

Query: 957 APACSS 962
            P  S+
Sbjct: 670 KPTLSA 675



 Score =  166 bits (420), Expect = 1e-40
 Identities = 165/629 (26%), Positives = 275/629 (43%), Gaps = 67/629 (10%)

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRE---RDPATYDLLVE--AKDGGGLSAQAFVRVDL 761
            L   AP    +D   G +   Q IDRE   R  A   L +E  A D         ++V++
Sbjct: 67   LENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFAND----KEICMIKVEI 122

Query: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTI 821
            +D+NDN P F+       IS+   PGT      A D D+G  G   Y L+  +   LF +
Sbjct: 123  QDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY-LLTRDDHGLFGL 181

Query: 822  DSTTG-------IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
            D  +         + +   L   +    +L+++A DGG         + + +  +     
Sbjct: 182  DVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSP 241

Query: 875  EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-------IFYRISS---GDLGGKFS 924
             FE P Y      ++PE++P+GTV     LN+++        + Y  SS     +   FS
Sbjct: 242  VFEAPSYLV----ELPENAPLGTVVI--DLNATDADEGPNGEVLYSFSSYVPDRVRELFS 295

Query: 925  IHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTS 983
            I P+ G IR +  LD+E   ++ + VQA+ LG  P  +  +V + ++D NDN P+    S
Sbjct: 296  IDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVS 355

Query: 984  -DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI------------ASPQPGV-FAID 1029
              +  +S+  PPGT + L R  DRDSG+NG ++  +              P   V F ++
Sbjct: 356  VRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLE 415

Query: 1030 RALGVLFL---NGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFE 1085
                  +    +  L    Q E  +T+ A D G  P  +     + ++++ ++ P +T  
Sbjct: 416  ENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKG 475

Query: 1086 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSV--DSAMF---GIRPYTG 1140
              V QV  +         +  Q   LG     S   YS+ PS   D +++    + P  G
Sbjct: 476  LYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVS---YSILPSHIGDVSIYTYVSVNPTNG 532

Query: 1141 WIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV 1200
             IY  R F++E T+ + F+V A           + TV V V D NDN+P  +   L    
Sbjct: 533  AIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDT 592

Query: 1201 EESPVPQG-----VIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALD 1253
             E  VP+      ++  + A+D D G++G+L Y ++  +D   F+++P++GE+       
Sbjct: 593  AELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFW 652

Query: 1254 REHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
             +     E+ V VTD G P  +A   + +
Sbjct: 653  EDVTPVVELVVKVTDHGKPTLSAVAKLII 681



 Score =  150 bits (378), Expect = 1e-35
 Identities = 154/589 (26%), Positives = 255/589 (43%), Gaps = 74/589 (12%)

Query: 608  IDSESGAISTIRTLDRE------VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
            +D++SG + T + +DRE       +  + L+V A D         C++ + + D+NDN P
Sbjct: 77   VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFAND------KEICMIKVEIQDINDNAP 130

Query: 662  IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH- 720
             F        I+E+A  G  F   +A D D+G  G   Y      L+ +    F +D   
Sbjct: 131  SFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY-----LLTRDDHGLFGLDVKS 185

Query: 721  --DG----QICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFN 772
              DG    ++ + + +DRE+    + L++ A DGG     A V+++++  D NDN PVF 
Sbjct: 186  RGDGTKFPELVIQKALDREQQNH-HTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFE 244

Query: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---IPGNVSSLFTIDSTTGIIY 829
              +Y+  + +    GT +I++ ATD D G  G V Y     +P  V  LF+ID  TG+I 
Sbjct: 245  APSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIR 304

Query: 830  LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED- 888
            +   L + E+  L + V A+D G      +  VT+ +            P   F+     
Sbjct: 305  VKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRN-----DNAPSIGFVSVRQG 359

Query: 889  -VPEDSPIGTVKAREPLNSSEP-----IFYRI-------SSGDLGGKFSIHP-------- 927
             + E +P GTV A   +   +      +  R+         G LGG     P        
Sbjct: 360  ALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYD 419

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEI 986
               T+ T +PLD ETQ    +T+ A+ G +P  +ST+   I ++D NDN P F +    +
Sbjct: 420  NFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVL 479

Query: 987  RISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGA--- 1043
            ++ +   PG  L    A+D D G+NG + YSI     G  +I   + V   NG++ A   
Sbjct: 480  QVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRS 539

Query: 1044 ---GEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHL-----VYQVEV 1093
                + +     + A+D G   H ++   V   V++  +++P      L       QV  
Sbjct: 540  FNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPR 599

Query: 1094 SESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
            +  L  +   ++      G    +  L Y +    D  +F I P +G I
Sbjct: 600  NAGLGYLVSTVRALDSDFG---ESGRLTYEIVDGNDDHLFEIDPSSGEI 645



 Score =  147 bits (372), Expect = 5e-35
 Identities = 134/463 (28%), Positives = 200/463 (43%), Gaps = 52/463 (11%)

Query: 912  YRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEV---NIT 968
            YR+          +    G + T++ +D E+  +     + QL      +  E+    + 
Sbjct: 64   YRVLENSAPHLLDVDADSGLLYTKQRIDRES--LCRHNAKCQLSLEVFANDKEICMIKVE 121

Query: 969  VMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAI 1028
            + D+NDN P+F     E+ IS+   PGT   L  A D D+G NGL  Y +     G+F +
Sbjct: 122  IQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGL 181

Query: 1029 D---RALGVLF----LNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSP 1080
            D   R  G  F    +  +L   +Q   TL L A D G  P++A + + V VI+  ++SP
Sbjct: 182  DVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSP 241

Query: 1081 SWTFEHLVYQVEVSESLSPMTQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPY 1138
               FE   Y VE+ E+    T ++   A     GP         S  P     +F I P 
Sbjct: 242  --VFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPK 299

Query: 1139 TGWIYLRRQFDYESTQTYNFRVFAW------IPEDGFLQNVSTTVIVRVWDENDNSPTF- 1191
            TG I ++   DYE        V A       IP           V V++ D NDN+P+  
Sbjct: 300  TGLIRVKGNLDYEENGMLEIDVQARDLGPNPIP-------AHCKVTVKLIDRNDNAPSIG 352

Query: 1192 LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF--------------F 1237
               V    + E+  P  VI  +   D DSGKNGQL   +L  G                F
Sbjct: 353  FVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPF 412

Query: 1238 KMNPNTGELINWVA---LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
            K+  N       V    LDRE +  + +T++  D GSPP N+T +  + + D NDN P F
Sbjct: 413  KLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRF 472

Query: 1295 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             + L   ++H   + G+     + +V A+DPD G N  V+YS+
Sbjct: 473  TKGLYVLQVHENNIPGE----YLGSVLAQDPDLGQNGTVSYSI 511



 Score =  142 bits (358), Expect = 2e-33
 Identities = 153/588 (26%), Positives = 249/588 (42%), Gaps = 80/588 (13%)

Query: 807  AYELIPGNVSSLFTIDSTTGIIYLTLPLS------HLESTTLSLMVSAQDGGGLTAVINA 860
            +Y ++  +   L  +D+ +G++Y    +       H     LSL V A D          
Sbjct: 63   SYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDK--------- 113

Query: 861  DVTIHIFQTTLAPAEFERPKYTFLVYE-DVPEDSPIGT----VKAREPLNSSEPIFYRIS 915
               I + +  +       P ++    E D+ E++  GT      A +P      +   + 
Sbjct: 114  --EICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLL 171

Query: 916  SGDLGGKFSIHPRL---GT----IRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNI 967
            + D  G F +  +    GT    +  +K LD E Q    L + A  G  P  S+T ++N+
Sbjct: 172  TRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINV 231

Query: 968  TVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG--- 1024
             V+D NDN P F   S  + + +  P GT +    A D D G NG + YS +S  P    
Sbjct: 232  KVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVR 291

Query: 1025 -VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSW 1082
             +F+ID   G++ + G+L   E   L + ++A D G +P  A   +TV +I++ +++PS 
Sbjct: 292  ELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSI 351

Query: 1083 TFEHLVYQVEVSESLSPMTQML-------------QTQAHPLGPQRAAS---------PL 1120
             F   V Q  +SE+  P T +              Q Q   LG                +
Sbjct: 352  GFVS-VRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSV 410

Query: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT--VI 1178
             + LE + D+       YT  +   R  D E+   YN  + A    DG    +++T    
Sbjct: 411  PFKLEENYDNF------YT--VVTDRPLDRETQDEYNVTIVA---RDGGSPPLNSTKSFA 459

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL------- 1231
            +++ DENDN P F   +  L+V E+ +P   +G + A D D G+NG + Y +L       
Sbjct: 460  IKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDV 519

Query: 1232 SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR-NATMAVYVSVTDINDN 1290
            S   +  +NP  G +    + + E     E  VL  D G+P    +   V V+V D+NDN
Sbjct: 520  SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDN 579

Query: 1291 RPFFP-QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             P      L      ++V     +  LV+TV A D D G +  +TY +
Sbjct: 580  APVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEI 627



 Score =  100 bits (248), Expect = 1e-20
 Identities = 71/213 (33%), Positives = 105/213 (49%), Gaps = 15/213 (7%)

Query: 1139 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLF 1197
            +G +Y +++ D ES   +N +    +  + F  +    +I V + D NDN+P+F  D + 
Sbjct: 81   SGLLYTKQRIDRESLCRHNAK--CQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIE 138

Query: 1198 LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD--GKFFKMNPNTG------ELINW 1249
            + + E+  P       +A D D+G+NG   Y L  D  G F     + G      EL+  
Sbjct: 139  MDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQ 198

Query: 1250 VALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLE 1309
             ALDRE + HH + +   D G PPR+AT+ + V V D NDN P F          V++ E
Sbjct: 199  KALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFE----APSYLVELPE 254

Query: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
              P+  +V  + A D DEG N EV YS SS  P
Sbjct: 255  NAPLGTVVIDLNATDADEGPNGEVLYSFSSYVP 287


>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 1007

 Score =  284 bits (727), Expect = 4e-76
 Identities = 235/744 (31%), Positives = 355/744 (47%), Gaps = 96/744 (12%)

Query: 42  RTQRSLLWLLVH----VWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQE 97
           R +R + WLL+     + L    G +A    L  SV E   P  LVG++   L    ++ 
Sbjct: 15  RLRRPMPWLLLLPLLLLLLLLLPGPAAS--QLRYSVPEEQAPGALVGNVARALGLELRRL 72

Query: 98  GSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLG----AV 150
           G G  L  +   +P      +   +G +    R+DRE    +     ++  +L     AV
Sbjct: 73  GPGC-LRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAV 131

Query: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             VE+ + D+ND+SPRFP  + QL VSE   PG  F +  A DPD G  S Q Y L  PS
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-SPS 190

Query: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
           +         F+L  +       PL   S    + L+LVL + LDRE+AA H L + A D
Sbjct: 191 E--------HFELDLK-------PLQENS----KVLELVLRKGLDREQAALHHLVLTAVD 231

Query: 271 GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF 330
           GG P R+G   + +RVLD NDN P F+Q  YR  +RED+ PG  V ++ A+D D G NG 
Sbjct: 232 GGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGE 291

Query: 331 VRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA 390
           +RYS+         S   +  +   F+++  +G VRV   LD E  + +Q+ V+A D G 
Sbjct: 292 LRYSL---------SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGP 342

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
            P     +V + ++DVNDN P + +  L     + V E A P   VA +SV+D D    +
Sbjct: 343 VPMAGHCKVLVDIVDVNDNAPEVVLTDL----YSPVPENATPNTIVAVLSVNDQDSGPNR 398

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESRDLYEL 507
           +               +SL LE      A LP    G    + L V GPLDRE   +Y +
Sbjct: 399 K---------------VSLGLE------ATLPFRLNGFGNSYTLVVSGPLDRERVAVYNI 437

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
            + ATD G P L++  TL + ++D+ND PP F +  Y   + E   PG ++  V A+D D
Sbjct: 438 TVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E   ++A + Y            SL  + +         +I+S SG++  + + D E   
Sbjct: 498 E--KENAEVTY------------SLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFR 543

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP-IFWRQVYNATIA-----EHAPVGHC 681
              + V AQD G PPLS+T   ++ V D+ND+ P I +    N++ A       AP G+ 
Sbjct: 544 EFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYL 603

Query: 682 FLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDL 741
             +V A D+DSG   ++ Y L            F+++ H G+I  ++ +  E   +T++L
Sbjct: 604 VTKVIAMDSDSGQNAWLFYHL----AQTSDLDLFKVELHTGEIRTTRKMGDE-SGSTFNL 658

Query: 742 LVEAKDGGGLSAQAFVRVDLEDVN 765
            V  +D G  S  A V + +  V+
Sbjct: 659 TVVVRDNGEPSLSASVAITVAVVD 682



 Score =  164 bits (416), Expect = 4e-40
 Identities = 179/682 (26%), Positives = 292/682 (42%), Gaps = 79/682 (11%)

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P  SQ  Y  SV E  APG +V  V+ +           L   + +L   C       ++
Sbjct: 39   PAASQLRY--SVPEEQAPGALVGNVARA-----------LGLELRRLGPGC------LRI 79

Query: 597  VHTAECGPSFA-IDSESGAISTIRTLDREV--QEAVELKVVAQDLGEPPLSATCLVSITV 653
             H     P +  +D  SGA+     +DRE   ++     +  + L   P++ +  V + +
Sbjct: 80   NHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA-VEVEI 138

Query: 654  DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
             D+NDN P F R  Y   ++E    G  F   +A D D G      Y L          +
Sbjct: 139  LDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-------SPSE 191

Query: 714  AFRIDPHDGQ-------ICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDV 764
             F +D    Q       + + + +DRE+  A + L++ A DGG    S  A + V + D 
Sbjct: 192  HFELDLKPLQENSKVLELVLRKGLDREQ-AALHHLVLTAVDGGIPARSGTAQISVRVLDT 250

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---IPGNVSSLFTI 821
            NDN P F+ STY   + +++ PGT ++ + A+D D G  G + Y L          LF+I
Sbjct: 251  NDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSI 310

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            D++TG + +   L + E+++  + V A D G +    +  V + I        E      
Sbjct: 311  DASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTD- 369

Query: 882  TFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG------TIRTR 935
               +Y  VPE++   T+ A   +N  +    R  S  LG + ++  RL       T+   
Sbjct: 370  ---LYSPVPENATPNTIVAVLSVNDQDSGPNRKVS--LGLEATLPFRLNGFGNSYTLVVS 424

Query: 936  KPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
             PLD E   V  +TV A  G  P  +S   + + + D+NDN P+FL  S  I I +   P
Sbjct: 425  GPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLP 484

Query: 995  GTALYLARAEDRDSGRNGLIRYSIAS------PQPGVFAIDRALGVLFLNGSLGAGEQRE 1048
            G  L   +A D D   N  + YS+        P     +I+ A G L+   S    + RE
Sbjct: 485  GVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFRE 544

Query: 1049 LTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSES----LSPMTQ- 1102
              +T+ A+D+G  P ++ +   V V++  +H+P     H++Y    + S    + P T  
Sbjct: 545  FFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP-----HILYPTSTNSSAAFEMVPRTAP 599

Query: 1103 --MLQTQAHPLGPQRAASP-LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 1159
               L T+   +      +  L Y L  + D  +F +  +TG I   R+   ES  T+N  
Sbjct: 600  AGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLT 659

Query: 1160 VFAWIPEDGFLQNVSTTVIVRV 1181
            V   +  D    ++S +V + V
Sbjct: 660  V---VVRDNGEPSLSASVAITV 678



 Score =  159 bits (403), Expect = 1e-38
 Identities = 142/528 (26%), Positives = 238/528 (45%), Gaps = 38/528 (7%)

Query: 842  LSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR 901
            LSL V A +   ++AV      + I         F RP Y   V E V   +      A+
Sbjct: 119  LSLEVLAHNPVAVSAV-----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQ 173

Query: 902  EP-LNSSEPIFYRISSGDLGGKFSIHP-----RLGTIRTRKPLDHETQPVVVLTVQAQLG 955
            +P + ++    Y +S  +   +  + P     ++  +  RK LD E   +  L + A  G
Sbjct: 174  DPDVGANSVQTYELSPSE-HFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDG 232

Query: 956  SAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLI 1014
              PA S T ++++ V+D NDN PAF +++  +++ + +PPGT +    A D D G NG +
Sbjct: 233  GIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGEL 292

Query: 1015 RYSIAS----PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAA-LLVL 1069
            RYS++S     +  +F+ID + G + + G L   E     + ++A D+G  P A    VL
Sbjct: 293  RYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVL 352

Query: 1070 TVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVD 1129
              +++  +++P      L   V  + + + +  +L       GP R  S     LE ++ 
Sbjct: 353  VDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVS---LGLEATLP 409

Query: 1130 SAMFGI-RPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST--TVIVRVWDEND 1186
              + G    YT  + +    D E    YN  V A    DG +  +++  T+ V + D ND
Sbjct: 410  FRLNGFGNSYT--LVVSGPLDRERVAVYNITVTA---TDGGIPQLTSLRTLKVEISDIND 464

Query: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-------GKFFKM 1239
            N P+FL D   + ++E+ +P  ++  + A D D  +N ++ Y LL           +  +
Sbjct: 465  NPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSI 524

Query: 1240 NPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP--FFPQC 1297
            N  +G L    + D E      +TV   D+GSPP ++T+   V V D+ND+ P   +P  
Sbjct: 525  NSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTS 584

Query: 1298 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
                     V    P   LVT V A D D G NA + Y ++    + L
Sbjct: 585  TNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL 632



 Score =  155 bits (393), Expect = 2e-37
 Identities = 162/628 (25%), Positives = 260/628 (41%), Gaps = 41/628 (6%)

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRE-----RDPATYDLLVEAKDGGGLSAQAFVRVDL 761
            L   +P+   +D   G + V++ IDRE     R      L V A +   +SA   V V++
Sbjct: 82   LGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA---VEVEI 138

Query: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN--VSSLF 819
             D+NDN P F    Y   +S+   PG       A D D G      YEL P       L 
Sbjct: 139  LDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLK 198

Query: 820  TIDSTTGIIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
             +   + ++ L L   L   ++    L+++A DGG       A +++ +  T      F+
Sbjct: 199  PLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFD 258

Query: 878  RPKYTFLVYEDVPEDSPIGTVKAREPLNSSE-PIFYRISSGDLGGK---FSIHPRLGTIR 933
            +  Y   + ED P  + +  + A +P   S   + Y +SS     +   FSI    G +R
Sbjct: 259  QSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318

Query: 934  TRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
                LD+E      + VQA   G  P     +V + ++DVNDN P  + T     + +  
Sbjct: 319  VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENA 378

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 1052
             P T + +    D+DSG N  +   + +  P           L ++G L         +T
Sbjct: 379  TPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNIT 438

Query: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112
            + A D G+    +L  L V I     +P  +F    Y + + E+  P   +   QA    
Sbjct: 439  VTATDGGIPQLTSLRTLKVEISDINDNPP-SFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 1113 PQRAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
             +  A      LE  +     ++   I   +G +Y    FDYE  + +   V A   +D 
Sbjct: 498  EKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEA---QDK 554

Query: 1169 FLQNVSTTVIVRVW--DENDNSPTFLH------DVLFLKVEESPVPQGVIGKITAIDMDS 1220
                +S+TV   V+  D ND++P  L+         F  V  +     ++ K+ A+D DS
Sbjct: 555  GSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDS 614

Query: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G+N  L Y L   SD   FK+  +TGE+     +  E      +TV+V D G P  +A++
Sbjct: 615  GQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASV 674

Query: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVK 1306
            A+ V+V D         + LP  + HVK
Sbjct: 675  AITVAVVD------RVSKILPDTQRHVK 696


>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 884

 Score =  284 bits (727), Expect = 4e-76
 Identities = 235/744 (31%), Positives = 355/744 (47%), Gaps = 96/744 (12%)

Query: 42  RTQRSLLWLLVH----VWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQE 97
           R +R + WLL+     + L    G +A    L  SV E   P  LVG++   L    ++ 
Sbjct: 15  RLRRPMPWLLLLPLLLLLLLLLPGPAAS--QLRYSVPEEQAPGALVGNVARALGLELRRL 72

Query: 98  GSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLG----AV 150
           G G  L  +   +P      +   +G +    R+DRE    +     ++  +L     AV
Sbjct: 73  GPGC-LRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAV 131

Query: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             VE+ + D+ND+SPRFP  + QL VSE   PG  F +  A DPD G  S Q Y L  PS
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-SPS 190

Query: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
           +         F+L  +       PL   S    + L+LVL + LDRE+AA H L + A D
Sbjct: 191 E--------HFELDLK-------PLQENS----KVLELVLRKGLDREQAALHHLVLTAVD 231

Query: 271 GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF 330
           GG P R+G   + +RVLD NDN P F+Q  YR  +RED+ PG  V ++ A+D D G NG 
Sbjct: 232 GGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGE 291

Query: 331 VRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA 390
           +RYS+         S   +  +   F+++  +G VRV   LD E  + +Q+ V+A D G 
Sbjct: 292 LRYSL---------SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGP 342

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
            P     +V + ++DVNDN P + +  L     + V E A P   VA +SV+D D    +
Sbjct: 343 VPMAGHCKVLVDIVDVNDNAPEVVLTDL----YSPVPENATPNTIVAVLSVNDQDSGPNR 398

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESRDLYEL 507
           +               +SL LE      A LP    G    + L V GPLDRE   +Y +
Sbjct: 399 K---------------VSLGLE------ATLPFRLNGFGNSYTLVVSGPLDRERVAVYNI 437

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
            + ATD G P L++  TL + ++D+ND PP F +  Y   + E   PG ++  V A+D D
Sbjct: 438 TVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E   ++A + Y            SL  + +         +I+S SG++  + + D E   
Sbjct: 498 E--KENAEVTY------------SLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFR 543

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP-IFWRQVYNATIA-----EHAPVGHC 681
              + V AQD G PPLS+T   ++ V D+ND+ P I +    N++ A       AP G+ 
Sbjct: 544 EFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYL 603

Query: 682 FLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDL 741
             +V A D+DSG   ++ Y L            F+++ H G+I  ++ +  E   +T++L
Sbjct: 604 VTKVIAMDSDSGQNAWLFYHL----AQTSDLDLFKVELHTGEIRTTRKMGDE-SGSTFNL 658

Query: 742 LVEAKDGGGLSAQAFVRVDLEDVN 765
            V  +D G  S  A V + +  V+
Sbjct: 659 TVVVRDNGEPSLSASVAITVAVVD 682



 Score =  164 bits (416), Expect = 4e-40
 Identities = 179/682 (26%), Positives = 292/682 (42%), Gaps = 79/682 (11%)

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P  SQ  Y  SV E  APG +V  V+ +           L   + +L   C       ++
Sbjct: 39   PAASQLRY--SVPEEQAPGALVGNVARA-----------LGLELRRLGPGC------LRI 79

Query: 597  VHTAECGPSFA-IDSESGAISTIRTLDREV--QEAVELKVVAQDLGEPPLSATCLVSITV 653
             H     P +  +D  SGA+     +DRE   ++     +  + L   P++ +  V + +
Sbjct: 80   NHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA-VEVEI 138

Query: 654  DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
             D+NDN P F R  Y   ++E    G  F   +A D D G      Y L          +
Sbjct: 139  LDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-------SPSE 191

Query: 714  AFRIDPHDGQ-------ICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDV 764
             F +D    Q       + + + +DRE+  A + L++ A DGG    S  A + V + D 
Sbjct: 192  HFELDLKPLQENSKVLELVLRKGLDREQ-AALHHLVLTAVDGGIPARSGTAQISVRVLDT 250

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---IPGNVSSLFTI 821
            NDN P F+ STY   + +++ PGT ++ + A+D D G  G + Y L          LF+I
Sbjct: 251  NDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSI 310

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            D++TG + +   L + E+++  + V A D G +    +  V + I        E      
Sbjct: 311  DASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTD- 369

Query: 882  TFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG------TIRTR 935
               +Y  VPE++   T+ A   +N  +    R  S  LG + ++  RL       T+   
Sbjct: 370  ---LYSPVPENATPNTIVAVLSVNDQDSGPNRKVS--LGLEATLPFRLNGFGNSYTLVVS 424

Query: 936  KPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
             PLD E   V  +TV A  G  P  +S   + + + D+NDN P+FL  S  I I +   P
Sbjct: 425  GPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLP 484

Query: 995  GTALYLARAEDRDSGRNGLIRYSIAS------PQPGVFAIDRALGVLFLNGSLGAGEQRE 1048
            G  L   +A D D   N  + YS+        P     +I+ A G L+   S    + RE
Sbjct: 485  GVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFRE 544

Query: 1049 LTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSES----LSPMTQ- 1102
              +T+ A+D+G  P ++ +   V V++  +H+P     H++Y    + S    + P T  
Sbjct: 545  FFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAP-----HILYPTSTNSSAAFEMVPRTAP 599

Query: 1103 --MLQTQAHPLGPQRAASP-LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 1159
               L T+   +      +  L Y L  + D  +F +  +TG I   R+   ES  T+N  
Sbjct: 600  AGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLT 659

Query: 1160 VFAWIPEDGFLQNVSTTVIVRV 1181
            V   +  D    ++S +V + V
Sbjct: 660  V---VVRDNGEPSLSASVAITV 678



 Score =  159 bits (403), Expect = 1e-38
 Identities = 142/528 (26%), Positives = 238/528 (45%), Gaps = 38/528 (7%)

Query: 842  LSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR 901
            LSL V A +   ++AV      + I         F RP Y   V E V   +      A+
Sbjct: 119  LSLEVLAHNPVAVSAV-----EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQ 173

Query: 902  EP-LNSSEPIFYRISSGDLGGKFSIHP-----RLGTIRTRKPLDHETQPVVVLTVQAQLG 955
            +P + ++    Y +S  +   +  + P     ++  +  RK LD E   +  L + A  G
Sbjct: 174  DPDVGANSVQTYELSPSE-HFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDG 232

Query: 956  SAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLI 1014
              PA S T ++++ V+D NDN PAF +++  +++ + +PPGT +    A D D G NG +
Sbjct: 233  GIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGEL 292

Query: 1015 RYSIAS----PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAA-LLVL 1069
            RYS++S     +  +F+ID + G + + G L   E     + ++A D+G  P A    VL
Sbjct: 293  RYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVL 352

Query: 1070 TVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVD 1129
              +++  +++P      L   V  + + + +  +L       GP R  S     LE ++ 
Sbjct: 353  VDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVS---LGLEATLP 409

Query: 1130 SAMFGI-RPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST--TVIVRVWDEND 1186
              + G    YT  + +    D E    YN  V A    DG +  +++  T+ V + D ND
Sbjct: 410  FRLNGFGNSYT--LVVSGPLDRERVAVYNITVTA---TDGGIPQLTSLRTLKVEISDIND 464

Query: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-------GKFFKM 1239
            N P+FL D   + ++E+ +P  ++  + A D D  +N ++ Y LL           +  +
Sbjct: 465  NPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSI 524

Query: 1240 NPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP--FFPQC 1297
            N  +G L    + D E      +TV   D+GSPP ++T+   V V D+ND+ P   +P  
Sbjct: 525  NSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTS 584

Query: 1298 LPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
                     V    P   LVT V A D D G NA + Y ++    + L
Sbjct: 585  TNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL 632



 Score =  155 bits (393), Expect = 2e-37
 Identities = 162/628 (25%), Positives = 260/628 (41%), Gaps = 41/628 (6%)

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRE-----RDPATYDLLVEAKDGGGLSAQAFVRVDL 761
            L   +P+   +D   G + V++ IDRE     R      L V A +   +SA   V V++
Sbjct: 82   LGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA---VEVEI 138

Query: 762  EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN--VSSLF 819
             D+NDN P F    Y   +S+   PG       A D D G      YEL P       L 
Sbjct: 139  LDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLK 198

Query: 820  TIDSTTGIIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
             +   + ++ L L   L   ++    L+++A DGG       A +++ +  T      F+
Sbjct: 199  PLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFD 258

Query: 878  RPKYTFLVYEDVPEDSPIGTVKAREPLNSSE-PIFYRISSGDLGGK---FSIHPRLGTIR 933
            +  Y   + ED P  + +  + A +P   S   + Y +SS     +   FSI    G +R
Sbjct: 259  QSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVR 318

Query: 934  TRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
                LD+E      + VQA   G  P     +V + ++DVNDN P  + T     + +  
Sbjct: 319  VIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENA 378

Query: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 1052
             P T + +    D+DSG N  +   + +  P           L ++G L         +T
Sbjct: 379  TPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNIT 438

Query: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112
            + A D G+    +L  L V I     +P  +F    Y + + E+  P   +   QA    
Sbjct: 439  VTATDGGIPQLTSLRTLKVEISDINDNPP-SFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 1113 PQRAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
             +  A      LE  +     ++   I   +G +Y    FDYE  + +   V A   +D 
Sbjct: 498  EKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEA---QDK 554

Query: 1169 FLQNVSTTVIVRVW--DENDNSPTFLH------DVLFLKVEESPVPQGVIGKITAIDMDS 1220
                +S+TV   V+  D ND++P  L+         F  V  +     ++ K+ A+D DS
Sbjct: 555  GSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDS 614

Query: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G+N  L Y L   SD   FK+  +TGE+     +  E      +TV+V D G P  +A++
Sbjct: 615  GQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASV 674

Query: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVK 1306
            A+ V+V D         + LP  + HVK
Sbjct: 675  AITVAVVD------RVSKILPDTQRHVK 696


>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 871

 Score =  277 bits (709), Expect = 4e-74
 Identities = 218/715 (30%), Positives = 328/715 (45%), Gaps = 99/715 (13%)

Query: 84  GDIRAGLPAAQQQEGS-------GFFLSEDSDDSPLLD--------DFHVHPDTGIIRTA 128
           G IR  +P  + QEG+        F L  DS  +  L          F V  D+G +   
Sbjct: 29  GQIRYPVPE-ESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIK 87

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
             +DRE     S      L  V +        E+ + DVNDH+PRFP   L L++ E +P
Sbjct: 88  NPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG  F L  A D D G  S   Y L        D       ++ R+ G L   LL     
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALD-------VKKRSDGSLVPELL----- 195

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
                   L + LDRE+ + +RL + A DGG P R+G   + + VLD NDN P F+Q  Y
Sbjct: 196 --------LEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E A  G  + ++ A+D DLGP+G V +           SG         F++   
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYF---------SGHTPDRVRNLFSLHPT 298

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G + +  PLD E++ +++  V ARDGG+        + + +LDVNDN P I V      
Sbjct: 299 TGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT----S 354

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
            +  + E A PG  VA +SV D D                  +G +SL +      FAL 
Sbjct: 355 ELGTLPESAEPGTVVALISVQDPDSG---------------SNGDVSLRIPD-HLPFAL- 397

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                  F L   GPLDRE++  Y++++ A+DAG+PPLST  T+ L ++D+ND PP F Q
Sbjct: 398 KSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ 457

Query: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
           + ++  V E   PG ++  ++ASD D     +A + Y++++   P N     S  +    
Sbjct: 458 RSHEVFVPENNRPGDLLCSLAASDPD--SGLNALISYSLLE---PRNRDVSASSFI---- 508

Query: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                +++ ++GA+   R+ D E  + ++ +V A+D G PPLS+T  V + V D+NDN P
Sbjct: 509 -----SLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAP 563

Query: 662 IFWR------QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
              R       +    +      GH   +VTA D DSG   ++ Y L    L    P  F
Sbjct: 564 AVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQL----LEAPDPSLF 619

Query: 716 RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPV 770
            +  + G++  +  I  +  P    ++V+      LS    + V LE+  D HPV
Sbjct: 620 AVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672



 Score =  153 bits (386), Expect = 1e-36
 Identities = 167/612 (27%), Positives = 258/612 (42%), Gaps = 43/612 (7%)

Query: 715  FRIDPHDGQICVSQDIDRERD---PATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVF 771
            FR+D   G + +   IDRE      A+  + +E    G L       V++ DVND+ P F
Sbjct: 75   FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYR-AEVEIVDVNDHAPRF 133

Query: 772  NPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY-- 829
                    I +   PG       A D D G     +Y L      +L     + G +   
Sbjct: 134  PRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPE 193

Query: 830  --LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE 887
              L  PL   + +   L+++A DGG       A++ + +         F++  Y   V E
Sbjct: 194  LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLE 253

Query: 888  DVPEDSPIGTVKAREP-LNSSEPIFYRISSGD---LGGKFSIHPRLGTIRTRKPLDHETQ 943
              P    +  + A +P L  S  + +  S      +   FS+HP  G +    PLD E++
Sbjct: 254  SAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESE 313

Query: 944  PVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 1002
                  V+A+ G +PA      + + ++DVNDN P    TS+   + ++  PGT + L  
Sbjct: 314  NYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALIS 373

Query: 1003 AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLF---LNGSLGAGEQRELTLTLRAEDQG 1059
             +D DSG NG +   I    P  FA+  A    F     G L    +    + + A D G
Sbjct: 374  VQDPDSGSNGDVSLRIPDHLP--FALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAG 431

Query: 1060 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
              P +    + + I     +P   F+   ++V V E+  P   +    A    P    + 
Sbjct: 432  NPPLSTHRTIFLNISDVNDNPPSFFQRS-HEVFVPENNRPGDLLCSLAASD--PDSGLNA 488

Query: 1120 L-RYSL-EPS----VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
            L  YSL EP       S+   + P TG ++  R FDYE TQT  F V A    D     +
Sbjct: 489  LISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQA---RDRGNPPL 545

Query: 1174 STTVIVR--VWDENDNSPTFLHDVL---FLKVEESPVPQG---VIGKITAIDMDSGKNGQ 1225
            S+TV VR  V D NDN+P  L        L  +  P   G   +I K+TA+D+DSG N  
Sbjct: 546  SSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAW 605

Query: 1226 LLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283
            + Y LL   D   F ++   GE+   V +  +     ++ ++V D GSPP + ++ + VS
Sbjct: 606  VSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVS 664

Query: 1284 VTDINDNRPFFP 1295
            + +  D  P  P
Sbjct: 665  LEE--DTHPVVP 674



 Score =  145 bits (367), Expect = 2e-34
 Identities = 136/509 (26%), Positives = 220/509 (43%), Gaps = 52/509 (10%)

Query: 606  FAIDSESGAISTIRTLDREVQEAVELKVVA--QDLGEPPLSATCLVSITVDDVNDNEPIF 663
            F +D +SGA+     +DRE    +    +   + + E PL       + + DVND+ P F
Sbjct: 75   FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMY-RAEVEIVDVNDHAPRF 133

Query: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH--- 720
             RQ  +  I E AP G  F    A DAD G      Y L        + + F +D     
Sbjct: 134  PRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRL-------SSNEHFALDVKKRS 186

Query: 721  DG----QICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPS 774
            DG    ++ + + +DRE+  + Y L++ A DGG    S  A +RV + DVNDN P F  S
Sbjct: 187  DGSLVPELLLEKPLDREKQ-SDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQS 245

Query: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---IPGNVSSLFTIDSTTGIIYLT 831
            +Y  S+ +    G  +I + A+D D G  G V +      P  V +LF++  TTG + L 
Sbjct: 246  SYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLL 305

Query: 832  LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE--DV 889
             PL           V A+DGG      +  + + +          +   Y  +  E   +
Sbjct: 306  GPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVN------DNAPYITVTSELGTL 359

Query: 890  PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG---------TIRTRKPLDH 940
            PE +  GTV A   +   +      S+GD+  +   H             ++ T  PLD 
Sbjct: 360  PESAEPGTVVALISVQDPDSG----SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDR 415

Query: 941  ETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY 999
            E +    + V A   G+ P  +   + + + DVNDN P+F + S E+ + +   PG  L 
Sbjct: 416  EAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLC 475

Query: 1000 LARAEDRDSGRNGLIRYSIASPQ------PGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
               A D DSG N LI YS+  P+          +++   G +    S    + + L   +
Sbjct: 476  SLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEV 535

Query: 1054 RAEDQGVHP-QAALLVLTVVIEKREHSPS 1081
            +A D+G  P  + + V   V++  +++P+
Sbjct: 536  QARDRGNPPLSSTVTVRLFVLDLNDNAPA 564



 Score =  133 bits (334), Expect = 1e-30
 Identities = 112/389 (28%), Positives = 178/389 (45%), Gaps = 25/389 (6%)

Query: 967  ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVF 1026
            + ++DVND+ P F R   ++ I +  PPG    L +A+D D G N +  Y ++S +   F
Sbjct: 121  VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH--F 178

Query: 1027 AID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREH 1078
            A+D         +  L L   L   +Q +  L L A D G  P++    L V V++  ++
Sbjct: 179  ALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDN 238

Query: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP--LGPQRAASPLRYSLEPSVDSAMFGIR 1136
            +P+  F+   Y++ V ES      ++Q  A    LGP    +       P     +F + 
Sbjct: 239  APA--FQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLH 296

Query: 1137 PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV--WDENDNSPTFLHD 1194
            P TG + L    D+ES   Y F V A    DG    +     +RV   D NDN+P     
Sbjct: 297  PTTGKLTLLGPLDFESENYYEFDVRA---RDGGSPAMEQHCSLRVDLLDVNDNAPYITVT 353

Query: 1195 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP--NTGELINWVAL 1252
                 + ES  P  V+  I+  D DSG NG +   +     F   +   N   L+    L
Sbjct: 354  SELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPL 413

Query: 1253 DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 1312
            DRE +  +++ V  +D G+PP +    ++++++D+NDN P F Q    +   V V E   
Sbjct: 414  DREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ----RSHEVFVPENNR 469

Query: 1313 VNMLVTTVFAKDPDEGNNAEVTYSVSSAR 1341
               L+ ++ A DPD G NA ++YS+   R
Sbjct: 470  PGDLLCSLAASDPDSGLNALISYSLLEPR 498



 Score =  128 bits (321), Expect = 4e-29
 Identities = 161/599 (26%), Positives = 249/599 (41%), Gaps = 58/599 (9%)

Query: 780  ISDETQPGTEIINV-----LATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPL 834
            + +E+Q GT + NV     L TD  S     VA E+   +    F +D  +G + +  P+
Sbjct: 35   VPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRH----FRVDLDSGALLIKNPI 90

Query: 835  SH--LESTTLSLMVSAQD-GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
                L   + S +V  +    G   +  A+V I +     AP  F R +    + E  P 
Sbjct: 91   DREALCGLSASCIVPLEFVTEGPLEMYRAEVEI-VDVNDHAP-RFPRQQLDLEIGEAAPP 148

Query: 892  DSPIGTVKAREP-LNSSEPIFYRISSGDLGG----KFSIHPRLGTIRTRKPLDHETQPVV 946
                   KA++  + S+    YR+SS +       K S    +  +   KPLD E Q   
Sbjct: 149  GQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDY 208

Query: 947  VLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAED 1005
             L + A  G  P  S T E+ ++V+DVNDN PAF ++S  I + ++ P G  L    A D
Sbjct: 209  RLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASD 268

Query: 1006 RDSGRNGLIRYSIASPQP----GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
             D G +G + +  +   P     +F++    G L L G L    +      +RA D G  
Sbjct: 269  PDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSP 328

Query: 1062 PQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 1120
                   L V +++  +++P  T    +  +  S     +  ++  Q    G     S L
Sbjct: 329  AMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVS-L 387

Query: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQF--------DYESTQTYNFRVFAWIPEDGFLQN 1172
            R       D   F ++        R QF        D E+  +Y+  V A    D     
Sbjct: 388  RIP-----DHLPFALKSA-----FRNQFSLVTAGPLDREAKSSYDIMVTA---SDAGNPP 434

Query: 1173 VST--TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230
            +ST  T+ + + D NDN P+F      + V E+  P  ++  + A D DSG N  + Y L
Sbjct: 435  LSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSL 494

Query: 1231 L-------SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283
            L       S   F  +NP TG +    + D E     +  V   DRG+PP ++T+ V + 
Sbjct: 495  LEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLF 554

Query: 1284 VTDINDNRP--FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
            V D+NDN P    P+  PG      +        L+T V A D D G NA V+Y +  A
Sbjct: 555  VLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEA 613



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 54/171 (31%), Positives = 80/171 (46%), Gaps = 12/171 (7%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 1238
            V + D ND++P F    L L++ E+  P        A D D G N  +  + LS  + F 
Sbjct: 121  VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNS-ISSYRLSSNEHFA 179

Query: 1239 MNPN-------TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
            ++           EL+    LDRE +  + + +   D G+PPR+ T  + VSV D+NDN 
Sbjct: 180  LDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNA 239

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
            P F Q        + VLE  P  M++  + A DPD G +  VT+  S   P
Sbjct: 240  PAFQQ----SSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTP 286



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 53/181 (29%), Positives = 81/181 (44%), Gaps = 11/181 (6%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---- 1234
            V V D NDN+P F      + V ES     V+ ++ A D D G +G + ++         
Sbjct: 230  VSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV 289

Query: 1235 -KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 1293
               F ++P TG+L     LD E   ++E  V   D GSP      ++ V + D+NDN P+
Sbjct: 290  RNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPY 349

Query: 1294 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAFGK 1353
                    EL       +P   +V  +  +DPD G+N +V+  +    P  L  K+AF  
Sbjct: 350  ITVT---SELGTLPESAEP-GTVVALISVQDPDSGSNGDVSLRIPDHLPFAL--KSAFRN 403

Query: 1354 Q 1354
            Q
Sbjct: 404  Q 404


>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 938

 Score =  277 bits (709), Expect = 4e-74
 Identities = 218/715 (30%), Positives = 328/715 (45%), Gaps = 99/715 (13%)

Query: 84  GDIRAGLPAAQQQEGS-------GFFLSEDSDDSPLLD--------DFHVHPDTGIIRTA 128
           G IR  +P  + QEG+        F L  DS  +  L          F V  D+G +   
Sbjct: 29  GQIRYPVPE-ESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIK 87

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
             +DRE     S      L  V +        E+ + DVNDH+PRFP   L L++ E +P
Sbjct: 88  NPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG  F L  A D D G  S   Y L        D       ++ R+ G L   LL     
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALD-------VKKRSDGSLVPELL----- 195

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
                   L + LDRE+ + +RL + A DGG P R+G   + + VLD NDN P F+Q  Y
Sbjct: 196 --------LEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E A  G  + ++ A+D DLGP+G V +           SG         F++   
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYF---------SGHTPDRVRNLFSLHPT 298

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G + +  PLD E++ +++  V ARDGG+        + + +LDVNDN P I V      
Sbjct: 299 TGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT----S 354

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
            +  + E A PG  VA +SV D D                  +G +SL +      FAL 
Sbjct: 355 ELGTLPESAEPGTVVALISVQDPDSG---------------SNGDVSLRIPD-HLPFAL- 397

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                  F L   GPLDRE++  Y++++ A+DAG+PPLST  T+ L ++D+ND PP F Q
Sbjct: 398 KSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ 457

Query: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
           + ++  V E   PG ++  ++ASD D     +A + Y++++   P N     S  +    
Sbjct: 458 RSHEVFVPENNRPGDLLCSLAASDPD--SGLNALISYSLLE---PRNRDVSASSFI---- 508

Query: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                +++ ++GA+   R+ D E  + ++ +V A+D G PPLS+T  V + V D+NDN P
Sbjct: 509 -----SLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAP 563

Query: 662 IFWR------QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
              R       +    +      GH   +VTA D DSG   ++ Y L    L    P  F
Sbjct: 564 AVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQL----LEAPDPSLF 619

Query: 716 RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPV 770
            +  + G++  +  I  +  P    ++V+      LS    + V LE+  D HPV
Sbjct: 620 AVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672



 Score =  153 bits (386), Expect = 1e-36
 Identities = 167/612 (27%), Positives = 258/612 (42%), Gaps = 43/612 (7%)

Query: 715  FRIDPHDGQICVSQDIDRERD---PATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVF 771
            FR+D   G + +   IDRE      A+  + +E    G L       V++ DVND+ P F
Sbjct: 75   FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYR-AEVEIVDVNDHAPRF 133

Query: 772  NPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY-- 829
                    I +   PG       A D D G     +Y L      +L     + G +   
Sbjct: 134  PRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPE 193

Query: 830  --LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE 887
              L  PL   + +   L+++A DGG       A++ + +         F++  Y   V E
Sbjct: 194  LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLE 253

Query: 888  DVPEDSPIGTVKAREP-LNSSEPIFYRISSGD---LGGKFSIHPRLGTIRTRKPLDHETQ 943
              P    +  + A +P L  S  + +  S      +   FS+HP  G +    PLD E++
Sbjct: 254  SAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESE 313

Query: 944  PVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 1002
                  V+A+ G +PA      + + ++DVNDN P    TS+   + ++  PGT + L  
Sbjct: 314  NYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALIS 373

Query: 1003 AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLF---LNGSLGAGEQRELTLTLRAEDQG 1059
             +D DSG NG +   I    P  FA+  A    F     G L    +    + + A D G
Sbjct: 374  VQDPDSGSNGDVSLRIPDHLP--FALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAG 431

Query: 1060 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
              P +    + + I     +P   F+   ++V V E+  P   +    A    P    + 
Sbjct: 432  NPPLSTHRTIFLNISDVNDNPPSFFQRS-HEVFVPENNRPGDLLCSLAASD--PDSGLNA 488

Query: 1120 L-RYSL-EPS----VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
            L  YSL EP       S+   + P TG ++  R FDYE TQT  F V A    D     +
Sbjct: 489  LISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQA---RDRGNPPL 545

Query: 1174 STTVIVR--VWDENDNSPTFLHDVL---FLKVEESPVPQG---VIGKITAIDMDSGKNGQ 1225
            S+TV VR  V D NDN+P  L        L  +  P   G   +I K+TA+D+DSG N  
Sbjct: 546  SSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAW 605

Query: 1226 LLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283
            + Y LL   D   F ++   GE+   V +  +     ++ ++V D GSPP + ++ + VS
Sbjct: 606  VSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVS 664

Query: 1284 VTDINDNRPFFP 1295
            + +  D  P  P
Sbjct: 665  LEE--DTHPVVP 674



 Score =  145 bits (367), Expect = 2e-34
 Identities = 136/509 (26%), Positives = 220/509 (43%), Gaps = 52/509 (10%)

Query: 606  FAIDSESGAISTIRTLDREVQEAVELKVVA--QDLGEPPLSATCLVSITVDDVNDNEPIF 663
            F +D +SGA+     +DRE    +    +   + + E PL       + + DVND+ P F
Sbjct: 75   FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMY-RAEVEIVDVNDHAPRF 133

Query: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH--- 720
             RQ  +  I E AP G  F    A DAD G      Y L        + + F +D     
Sbjct: 134  PRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRL-------SSNEHFALDVKKRS 186

Query: 721  DG----QICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPS 774
            DG    ++ + + +DRE+  + Y L++ A DGG    S  A +RV + DVNDN P F  S
Sbjct: 187  DGSLVPELLLEKPLDREKQ-SDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQS 245

Query: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---IPGNVSSLFTIDSTTGIIYLT 831
            +Y  S+ +    G  +I + A+D D G  G V +      P  V +LF++  TTG + L 
Sbjct: 246  SYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLL 305

Query: 832  LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE--DV 889
             PL           V A+DGG      +  + + +          +   Y  +  E   +
Sbjct: 306  GPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVN------DNAPYITVTSELGTL 359

Query: 890  PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG---------TIRTRKPLDH 940
            PE +  GTV A   +   +      S+GD+  +   H             ++ T  PLD 
Sbjct: 360  PESAEPGTVVALISVQDPDSG----SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDR 415

Query: 941  ETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY 999
            E +    + V A   G+ P  +   + + + DVNDN P+F + S E+ + +   PG  L 
Sbjct: 416  EAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLC 475

Query: 1000 LARAEDRDSGRNGLIRYSIASPQ------PGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
               A D DSG N LI YS+  P+          +++   G +    S    + + L   +
Sbjct: 476  SLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEV 535

Query: 1054 RAEDQGVHP-QAALLVLTVVIEKREHSPS 1081
            +A D+G  P  + + V   V++  +++P+
Sbjct: 536  QARDRGNPPLSSTVTVRLFVLDLNDNAPA 564



 Score =  133 bits (334), Expect = 1e-30
 Identities = 112/389 (28%), Positives = 178/389 (45%), Gaps = 25/389 (6%)

Query: 967  ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVF 1026
            + ++DVND+ P F R   ++ I +  PPG    L +A+D D G N +  Y ++S +   F
Sbjct: 121  VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH--F 178

Query: 1027 AID-------RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREH 1078
            A+D         +  L L   L   +Q +  L L A D G  P++    L V V++  ++
Sbjct: 179  ALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDN 238

Query: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP--LGPQRAASPLRYSLEPSVDSAMFGIR 1136
            +P+  F+   Y++ V ES      ++Q  A    LGP    +       P     +F + 
Sbjct: 239  APA--FQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLH 296

Query: 1137 PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRV--WDENDNSPTFLHD 1194
            P TG + L    D+ES   Y F V A    DG    +     +RV   D NDN+P     
Sbjct: 297  PTTGKLTLLGPLDFESENYYEFDVRA---RDGGSPAMEQHCSLRVDLLDVNDNAPYITVT 353

Query: 1195 VLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNP--NTGELINWVAL 1252
                 + ES  P  V+  I+  D DSG NG +   +     F   +   N   L+    L
Sbjct: 354  SELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPL 413

Query: 1253 DREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQP 1312
            DRE +  +++ V  +D G+PP +    ++++++D+NDN P F Q    +   V V E   
Sbjct: 414  DREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ----RSHEVFVPENNR 469

Query: 1313 VNMLVTTVFAKDPDEGNNAEVTYSVSSAR 1341
               L+ ++ A DPD G NA ++YS+   R
Sbjct: 470  PGDLLCSLAASDPDSGLNALISYSLLEPR 498



 Score =  128 bits (321), Expect = 4e-29
 Identities = 161/599 (26%), Positives = 249/599 (41%), Gaps = 58/599 (9%)

Query: 780  ISDETQPGTEIINV-----LATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPL 834
            + +E+Q GT + NV     L TD  S     VA E+   +    F +D  +G + +  P+
Sbjct: 35   VPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRH----FRVDLDSGALLIKNPI 90

Query: 835  SH--LESTTLSLMVSAQD-GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPE 891
                L   + S +V  +    G   +  A+V I +     AP  F R +    + E  P 
Sbjct: 91   DREALCGLSASCIVPLEFVTEGPLEMYRAEVEI-VDVNDHAP-RFPRQQLDLEIGEAAPP 148

Query: 892  DSPIGTVKAREP-LNSSEPIFYRISSGDLGG----KFSIHPRLGTIRTRKPLDHETQPVV 946
                   KA++  + S+    YR+SS +       K S    +  +   KPLD E Q   
Sbjct: 149  GQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDY 208

Query: 947  VLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAED 1005
             L + A  G  P  S T E+ ++V+DVNDN PAF ++S  I + ++ P G  L    A D
Sbjct: 209  RLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASD 268

Query: 1006 RDSGRNGLIRYSIASPQP----GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 1061
             D G +G + +  +   P     +F++    G L L G L    +      +RA D G  
Sbjct: 269  PDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSP 328

Query: 1062 PQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 1120
                   L V +++  +++P  T    +  +  S     +  ++  Q    G     S L
Sbjct: 329  AMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVS-L 387

Query: 1121 RYSLEPSVDSAMFGIRPYTGWIYLRRQF--------DYESTQTYNFRVFAWIPEDGFLQN 1172
            R       D   F ++        R QF        D E+  +Y+  V A    D     
Sbjct: 388  RIP-----DHLPFALKSA-----FRNQFSLVTAGPLDREAKSSYDIMVTA---SDAGNPP 434

Query: 1173 VST--TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230
            +ST  T+ + + D NDN P+F      + V E+  P  ++  + A D DSG N  + Y L
Sbjct: 435  LSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSL 494

Query: 1231 L-------SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVS 1283
            L       S   F  +NP TG +    + D E     +  V   DRG+PP ++T+ V + 
Sbjct: 495  LEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLF 554

Query: 1284 VTDINDNRP--FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
            V D+NDN P    P+  PG      +        L+T V A D D G NA V+Y +  A
Sbjct: 555  VLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEA 613



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 54/171 (31%), Positives = 80/171 (46%), Gaps = 12/171 (7%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 1238
            V + D ND++P F    L L++ E+  P        A D D G N  +  + LS  + F 
Sbjct: 121  VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNS-ISSYRLSSNEHFA 179

Query: 1239 MNPN-------TGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
            ++           EL+    LDRE +  + + +   D G+PPR+ T  + VSV D+NDN 
Sbjct: 180  LDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNA 239

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
            P F Q        + VLE  P  M++  + A DPD G +  VT+  S   P
Sbjct: 240  PAFQQ----SSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTP 286



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 53/181 (29%), Positives = 81/181 (44%), Gaps = 11/181 (6%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---- 1234
            V V D NDN+P F      + V ES     V+ ++ A D D G +G + ++         
Sbjct: 230  VSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV 289

Query: 1235 -KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 1293
               F ++P TG+L     LD E   ++E  V   D GSP      ++ V + D+NDN P+
Sbjct: 290  RNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPY 349

Query: 1294 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAFGK 1353
                    EL       +P   +V  +  +DPD G+N +V+  +    P  L  K+AF  
Sbjct: 350  ITVT---SELGTLPESAEP-GTVVALISVQDPDSGSNGDVSLRIPDHLPFAL--KSAFRN 403

Query: 1354 Q 1354
            Q
Sbjct: 404  Q 404


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  277 bits (708), Expect = 6e-74
 Identities = 258/886 (29%), Positives = 379/886 (42%), Gaps = 95/886 (10%)

Query: 8   MGEGRQQRRAPVGKLLLL-PGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAASGSSAQL 66
           M  G   RR P   LL+L P R +      G  G   QR LL  ++   L   + S    
Sbjct: 1   MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGG---QRLLLPSMLLALLLLLAPSPGHA 57

Query: 67  FNLTLSVDEGLPPDTLVGDIRA--GLPAA---QQQEGSGFFLSEDSDDSPLLDDFHVHPD 121
             +   V E  PP+TL+G + A  G P      + E    +L  D     +         
Sbjct: 58  TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDR 117

Query: 122 TGIIRTARRLDRERRDHYSFVAATLL-----GAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
            G+     +L  +       V+ T L       +++ +I V D+ND++P F    + L +
Sbjct: 118 EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAI 177

Query: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLL 236
            E +  G+ F +P+A D DAG      Y L          AGP  Q  +         L 
Sbjct: 178 PENTNIGSLFPIPLASDRDAGPNGVASYEL---------QAGPEAQELFG--------LQ 220

Query: 237 PGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
                  +   L+++  LDRE   ++ L I+  DGG P R     + + VLD NDN P F
Sbjct: 221 VAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKF 280

Query: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
           E+  Y A + E++  G  V +V+A D D G N  + Y+    Q P               
Sbjct: 281 ERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF--HQAPEV--------VRRLL 330

Query: 357 AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV- 415
            ++  +G++ V  P+DRE  +  +  V A+D G  P+ A  +V + V D+NDN P I + 
Sbjct: 331 RLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIR 390

Query: 416 ---LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
              L   + G+A +SE       VA V VSD D     E E      V  GD    L   
Sbjct: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRD-----EGENAAVTCVVAGDVPFQLRQA 445

Query: 473 GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
              G            +FL    PLD E    Y + +VA D+G+PPLS+  +L ++V D+
Sbjct: 446 SETG------SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDV 499

Query: 533 NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
           ND  P+F+Q   + +  E   PG V+  ++ASDAD   +                     
Sbjct: 500 NDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN--------------------- 538

Query: 593 QSKMVHTAECGPS----FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
            +++V++ E  P+    F I  E+G I    +LDRE +E+ ELKVVA D G P L  T  
Sbjct: 539 -AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT 597

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLS 708
           V + V D NDN+P F    YN ++ E+ P       VT  D D G    ++       LS
Sbjct: 598 VLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ-------LS 650

Query: 709 YEAPQA-FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVN 765
            E     F I    G I  S   DRE+  +TY   ++A DGG     A+V V +   D N
Sbjct: 651 VEQDNGDFVIQNGTGTILSSLSFDREQQ-STYTFQLKAVDGGVPPRSAYVGVTINVLDEN 709

Query: 766 DNHPVFN--PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 823
           DN P      +T    ++ +T+ G  +  V A D DSG+   + Y +  GN   LF I S
Sbjct: 710 DNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGS 769

Query: 824 TTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 869
            +G I L   +         L+V   D G       A V +++ +T
Sbjct: 770 HSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNET 815



 Score =  216 bits (550), Expect = 1e-55
 Identities = 203/745 (27%), Positives = 325/745 (43%), Gaps = 79/745 (10%)

Query: 604  PSFAIDSESGAISTIRT-LDRE-VQEA----------VELKVVAQDLGEPPLSATCLVSI 651
            P   +D ++G I T  T +DRE ++E           +E +V   DL +          I
Sbjct: 97   PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156

Query: 652  TVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
             V D+NDN P F   V    I E+  +G  F    ASD D+G  G   Y L  G    EA
Sbjct: 157  EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG---PEA 213

Query: 712  PQAFRI------DPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLED 763
             + F +      +    Q+ V  ++DRER  + YDL ++ +DGG    ++ A +RV + D
Sbjct: 214  QELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTVLD 272

Query: 764  VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTI 821
             NDN P F   +Y   +S+ +  G  +I V A D D G    + Y     P  V  L  +
Sbjct: 273  TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            D  TG+I +  P+   + +TL   V A+D G       A V + +          E    
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392

Query: 882  TFLVY--------EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT-- 931
              + +        EDV E++ +  V+  +           + +GD+  +       G+  
Sbjct: 393  GLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDS 452

Query: 932  -----IRTRKPLDHE-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 985
                 ++T  PLD+E  +   +  V    G+ P  S+  + + V+DVNDN P F ++  E
Sbjct: 453  KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512

Query: 986  IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP---GVFAIDRALGVLFLNGSLG 1042
            +   +   PG  +    A D DSG N  + YS+  P+P   G+F I    G + +  SL 
Sbjct: 513  VAFPENNKPGEVIAEITASDADSGSNAELVYSL-EPEPAAKGLFTISPETGEIQVKTSLD 571

Query: 1043 AGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQV-EVSESLSPM 1100
              ++    L + A D+G    Q    VL  V++  ++ P +      + V E   +LSP+
Sbjct: 572  REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPV 631

Query: 1101 TQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
              +        G +   + ++ S+E   D+  F I+  TG I     FD E   TY F++
Sbjct: 632  GMVTVID----GDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYTFQL 685

Query: 1161 FAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFL------HDVLFLKVEESPVPQGVIGK 1212
             A    DG +  ++    V + V DENDN+P         H +L         PQ  +G+
Sbjct: 686  KA---VDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLL--------TPQTRLGE 734

Query: 1213 ----ITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLV 1266
                + A D DSG N +L+Y +     +  F++  ++G +     ++R H G H + V V
Sbjct: 735  TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794

Query: 1267 TDRGSPPRNATMAVYVSVTDINDNR 1291
            +DRG PPR  T  V++ V +   NR
Sbjct: 795  SDRGKPPRYGTALVHLYVNETLANR 819



 Score =  183 bits (464), Expect = 1e-45
 Identities = 188/695 (27%), Positives = 293/695 (42%), Gaps = 55/695 (7%)

Query: 695  YGFIEYS-LYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDRER----------DPATYDLL 742
            YGF +   LY   L   AP   R+D   G I  ++  IDRE           DP   +  
Sbjct: 81   YGFPDVGHLYK--LEVGAPY-LRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFE 137

Query: 743  VEAKD--GGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDS 800
            V   D    G       +++++D+NDN P F       +I + T  G+     LA+D+D+
Sbjct: 138  VSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDA 197

Query: 801  GIYGTVAYELIPG-NVSSLFTIDSTTG--------IIYLTLPLSHLESTTLSLMVSAQDG 851
            G  G  +YEL  G     LF +             I+   L     +S  L++ V  QDG
Sbjct: 198  GPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKV--QDG 255

Query: 852  GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP---LNSSE 908
            G      +A + + +  T     +FERP Y   + E+ P    +  VKA +     N+  
Sbjct: 256  GSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315

Query: 909  PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNI 967
               +  +   +     +    G I  + P+D E    +  +V A+  G+ P  +  +V +
Sbjct: 316  EYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375

Query: 968  TVMDVNDNHPAF------LRTSDE--IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 1019
            TV D+NDN P        L T  +    IS+     TA+ L +  DRD G N  +   +A
Sbjct: 376  TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVA 435

Query: 1020 SPQPGVFAIDRALG-------VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071
               P         G        L     L   + ++ T+ + A D G  P ++   L V 
Sbjct: 436  GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQ 495

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS-VDS 1130
            V++  +++P   F   V +V   E+  P   + +  A        A  L YSLEP     
Sbjct: 496  VVDVNDNAP--VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE-LVYSLEPEPAAK 552

Query: 1131 AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 1190
             +F I P TG I ++   D E  ++Y  +V A       LQ  +T V+V V D NDN P 
Sbjct: 553  GLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT-VLVNVLDCNDNDPK 611

Query: 1191 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWV 1250
            F+       V E+      +G +T ID D G+N Q+   +  D   F +   TG +++ +
Sbjct: 612  FMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSL 671

Query: 1251 ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
            + DRE +  +   +   D G PPR+A + V ++V D NDN P+     P    H  +   
Sbjct: 672  SFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI--TAPSNTSHKLLTPQ 729

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
              +   V+ V A+D D G NAE+ YS++   P  L
Sbjct: 730  TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 764



 Score =  167 bits (423), Expect = 6e-41
 Identities = 171/675 (25%), Positives = 293/675 (43%), Gaps = 80/675 (11%)

Query: 515  GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
            GSP L   +   + V D+ND  P F+      ++ E    G++     ASD D       
Sbjct: 147  GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD------- 196

Query: 575  WLRYTVVQLSAPCNLGSLQSKMVHTAE--CGPSFAIDSESGA--ISTIRTLDREVQEAVE 630
                     + P  + S + +    A+   G   A D E     +  +  LDRE  ++ +
Sbjct: 197  ---------AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247

Query: 631  LKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDA 690
            L +  QD G PP +++ L+ +TV D NDN P F R  Y A ++E++P+GH  +QV A+D+
Sbjct: 248  LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307

Query: 691  DSGLYGFIEYSLYDGFLSYEAPQA----FRIDPHDGQICVSQDIDRERDPATYDLLVEAK 746
            D G    IEY+       ++AP+      R+D + G I V   +DRE D +T    V AK
Sbjct: 308  DQGANAEIEYTF------HQAPEVVRRLLRLDRNTGLITVQGPVDRE-DLSTLRFSVLAK 360

Query: 747  DGG--GLSAQAFVRVDLEDVNDNHP--------VFNPSTYVTSISDETQPGTEIINVLAT 796
            D G    SA+A V V ++D+NDN P        +      + +IS++    T +  V  +
Sbjct: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420

Query: 797  DQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------IIYLTLPLSHLESTTLSLMVSAQ 849
            D+D G    V   ++ G+V       S TG        +  T PL + +    ++ + A 
Sbjct: 421  DRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479

Query: 850  DGGG---------LTAVINADVTIHIFQTTLAPAEF-ERPKYTFLVYEDVPEDSPIGTVK 899
            D G             V++ +    +F  ++    F E  K   ++ E    D+  G   
Sbjct: 480  DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG--- 536

Query: 900  AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA 959
                 +++E ++         G F+I P  G I+ +  LD E +    L V A    +P+
Sbjct: 537  -----SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS 591

Query: 960  CSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI 1018
               T  V + V+D NDN P F+ +     + +  P  + + +    D D G N  ++ S+
Sbjct: 592  LQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV 651

Query: 1019 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKRE 1077
                 G F I    G +  + S    +Q   T  L+A D GV P++A + +T+ V+++ +
Sbjct: 652  EQDN-GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDEND 710

Query: 1078 HSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG---PQRAASPLRYSLEPSVDSAMFG 1134
            ++P  T           + L+P T++ +T +            + L YS+       +F 
Sbjct: 711  NAPYITAPSNTSH----KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQ 766

Query: 1135 IRPYTGWIYLRRQFD 1149
            I  ++G I L ++ +
Sbjct: 767  IGSHSGAITLEKEIE 781



 Score =  134 bits (336), Expect = 8e-31
 Identities = 158/559 (28%), Positives = 223/559 (39%), Gaps = 89/559 (15%)

Query: 121 DTGIIRTARRLDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQL 174
           +TG+I     +DRE      F V A   G     A  QV + V D+ND++P   +  + L
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGL 394

Query: 175 --------DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
                   ++SE     TA  L    D D G       T V   D+P       FQLR  
Sbjct: 395 VTHQDGMANISEDVAEETAVALVQVSDRDEG--ENAAVTCVVAGDVP-------FQLRQA 445

Query: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
           +          GS S  +   L     LD E+   + ++I A D G P  +   S++++V
Sbjct: 446 SE--------TGSDSKKKYF-LQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQV 496

Query: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
           +D NDN PVF Q     A  E+ +PG  +  + A+D D G N  + YS+     P A   
Sbjct: 497 VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE--PAA--- 551

Query: 347 GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
                    F +   +G ++V   LDRE +  ++L V A D G+     T  V + VLD 
Sbjct: 552 ------KGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN P     F+  G    V E       V  V+V D D          GE      +  
Sbjct: 606 NDNDPK----FMLSGYNFSVMENMPALSPVGMVTVIDGD---------KGE------NAQ 646

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
           + LS+E   GDF +  G   G     +    DRE +  Y   L A D G PP S    + 
Sbjct: 647 VQLSVEQDNGDFVIQNG--TGTILSSLS--FDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702

Query: 527 LRVADLNDQPPLF---SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
           + V D ND  P     S   +K    +    G  V  V+A D D   +  A L Y++   
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVN--AELIYSIAG- 758

Query: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL 643
             P  L                F I S SGAI+  + ++R       L V   D G+PP 
Sbjct: 759 GNPYGL----------------FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802

Query: 644 SATCLVSITVDDVNDNEPI 662
             T LV + V++   N  +
Sbjct: 803 YGTALVHLYVNETLANRTL 821



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 62/239 (25%), Positives = 94/239 (39%), Gaps = 36/239 (15%)

Query: 66  LFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGII 125
           L     SV E +P  + VG +   +    + E +   LS + D+     DF +   TG I
Sbjct: 614 LSGYNFSVMENMPALSPVGMVT--VIDGDKGENAQVQLSVEQDNG----DFVIQNGTGTI 667

Query: 126 RTARRLDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSEL 179
            ++   DRE++  Y+F    + G V      V V I V D ND++P              
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYIT----------- 716

Query: 180 SPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLP-G 238
           +P  T+ +L     P   L  T      +  D     +G   +L Y   G  P  L   G
Sbjct: 717 APSNTSHKLLT---PQTRLGETVSQVAAEDFD-----SGVNAELIYSIAGGNPYGLFQIG 768

Query: 239 SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFE 297
           S S      + L + ++R     HRL ++  D G+P R G   V L V +   N  + E
Sbjct: 769 SHSGA----ITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  277 bits (708), Expect = 6e-74
 Identities = 258/886 (29%), Positives = 379/886 (42%), Gaps = 95/886 (10%)

Query: 8   MGEGRQQRRAPVGKLLLL-PGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAASGSSAQL 66
           M  G   RR P   LL+L P R +      G  G   QR LL  ++   L   + S    
Sbjct: 1   MDSGAGGRRCPEAALLILGPPRMEHLRHSPGPGG---QRLLLPSMLLALLLLLAPSPGHA 57

Query: 67  FNLTLSVDEGLPPDTLVGDIRA--GLPAA---QQQEGSGFFLSEDSDDSPLLDDFHVHPD 121
             +   V E  PP+TL+G + A  G P      + E    +L  D     +         
Sbjct: 58  TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDR 117

Query: 122 TGIIRTARRLDRERRDHYSFVAATLL-----GAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
            G+     +L  +       V+ T L       +++ +I V D+ND++P F    + L +
Sbjct: 118 EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAI 177

Query: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLL 236
            E +  G+ F +P+A D DAG      Y L          AGP  Q  +         L 
Sbjct: 178 PENTNIGSLFPIPLASDRDAGPNGVASYEL---------QAGPEAQELFG--------LQ 220

Query: 237 PGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
                  +   L+++  LDRE   ++ L I+  DGG P R     + + VLD NDN P F
Sbjct: 221 VAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKF 280

Query: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
           E+  Y A + E++  G  V +V+A D D G N  + Y+    Q P               
Sbjct: 281 ERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF--HQAPEV--------VRRLL 330

Query: 357 AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV- 415
            ++  +G++ V  P+DRE  +  +  V A+D G  P+ A  +V + V D+NDN P I + 
Sbjct: 331 RLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIR 390

Query: 416 ---LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
              L   + G+A +SE       VA V VSD D     E E      V  GD    L   
Sbjct: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRD-----EGENAAVTCVVAGDVPFQLRQA 445

Query: 473 GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADL 532
              G            +FL    PLD E    Y + +VA D+G+PPLS+  +L ++V D+
Sbjct: 446 SETG------SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDV 499

Query: 533 NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
           ND  P+F+Q   + +  E   PG V+  ++ASDAD   +                     
Sbjct: 500 NDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSN--------------------- 538

Query: 593 QSKMVHTAECGPS----FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
            +++V++ E  P+    F I  E+G I    +LDRE +E+ ELKVVA D G P L  T  
Sbjct: 539 -AELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT 597

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLS 708
           V + V D NDN+P F    YN ++ E+ P       VT  D D G    ++       LS
Sbjct: 598 VLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ-------LS 650

Query: 709 YEAPQA-FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVN 765
            E     F I    G I  S   DRE+  +TY   ++A DGG     A+V V +   D N
Sbjct: 651 VEQDNGDFVIQNGTGTILSSLSFDREQQ-STYTFQLKAVDGGVPPRSAYVGVTINVLDEN 709

Query: 766 DNHPVFN--PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 823
           DN P      +T    ++ +T+ G  +  V A D DSG+   + Y +  GN   LF I S
Sbjct: 710 DNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGS 769

Query: 824 TTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQT 869
            +G I L   +         L+V   D G       A V +++ +T
Sbjct: 770 HSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNET 815



 Score =  216 bits (550), Expect = 1e-55
 Identities = 203/745 (27%), Positives = 325/745 (43%), Gaps = 79/745 (10%)

Query: 604  PSFAIDSESGAISTIRT-LDRE-VQEA----------VELKVVAQDLGEPPLSATCLVSI 651
            P   +D ++G I T  T +DRE ++E           +E +V   DL +          I
Sbjct: 97   PYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQI 156

Query: 652  TVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
             V D+NDN P F   V    I E+  +G  F    ASD D+G  G   Y L  G    EA
Sbjct: 157  EVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAG---PEA 213

Query: 712  PQAFRI------DPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLED 763
             + F +      +    Q+ V  ++DRER  + YDL ++ +DGG    ++ A +RV + D
Sbjct: 214  QELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTVLD 272

Query: 764  VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTI 821
             NDN P F   +Y   +S+ +  G  +I V A D D G    + Y     P  V  L  +
Sbjct: 273  TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332

Query: 822  DSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKY 881
            D  TG+I +  P+   + +TL   V A+D G       A V + +          E    
Sbjct: 333  DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392

Query: 882  TFLVY--------EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT-- 931
              + +        EDV E++ +  V+  +           + +GD+  +       G+  
Sbjct: 393  GLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDS 452

Query: 932  -----IRTRKPLDHE-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 985
                 ++T  PLD+E  +   +  V    G+ P  S+  + + V+DVNDN P F ++  E
Sbjct: 453  KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512

Query: 986  IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP---GVFAIDRALGVLFLNGSLG 1042
            +   +   PG  +    A D DSG N  + YS+  P+P   G+F I    G + +  SL 
Sbjct: 513  VAFPENNKPGEVIAEITASDADSGSNAELVYSL-EPEPAAKGLFTISPETGEIQVKTSLD 571

Query: 1043 AGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQV-EVSESLSPM 1100
              ++    L + A D+G    Q    VL  V++  ++ P +      + V E   +LSP+
Sbjct: 572  REQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPV 631

Query: 1101 TQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
              +        G +   + ++ S+E   D+  F I+  TG I     FD E   TY F++
Sbjct: 632  GMVTVID----GDKGENAQVQLSVEQ--DNGDFVIQNGTGTILSSLSFDREQQSTYTFQL 685

Query: 1161 FAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFL------HDVLFLKVEESPVPQGVIGK 1212
             A    DG +  ++    V + V DENDN+P         H +L         PQ  +G+
Sbjct: 686  KA---VDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLL--------TPQTRLGE 734

Query: 1213 ----ITAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLV 1266
                + A D DSG N +L+Y +     +  F++  ++G +     ++R H G H + V V
Sbjct: 735  TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794

Query: 1267 TDRGSPPRNATMAVYVSVTDINDNR 1291
            +DRG PPR  T  V++ V +   NR
Sbjct: 795  SDRGKPPRYGTALVHLYVNETLANR 819



 Score =  183 bits (464), Expect = 1e-45
 Identities = 188/695 (27%), Positives = 293/695 (42%), Gaps = 55/695 (7%)

Query: 695  YGFIEYS-LYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDRER----------DPATYDLL 742
            YGF +   LY   L   AP   R+D   G I  ++  IDRE           DP   +  
Sbjct: 81   YGFPDVGHLYK--LEVGAPY-LRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFE 137

Query: 743  VEAKD--GGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDS 800
            V   D    G       +++++D+NDN P F       +I + T  G+     LA+D+D+
Sbjct: 138  VSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDA 197

Query: 801  GIYGTVAYELIPG-NVSSLFTIDSTTG--------IIYLTLPLSHLESTTLSLMVSAQDG 851
            G  G  +YEL  G     LF +             I+   L     +S  L++ V  QDG
Sbjct: 198  GPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKV--QDG 255

Query: 852  GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP---LNSSE 908
            G      +A + + +  T     +FERP Y   + E+ P    +  VKA +     N+  
Sbjct: 256  GSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEI 315

Query: 909  PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNI 967
               +  +   +     +    G I  + P+D E    +  +V A+  G+ P  +  +V +
Sbjct: 316  EYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVV 375

Query: 968  TVMDVNDNHPAF------LRTSDE--IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 1019
            TV D+NDN P        L T  +    IS+     TA+ L +  DRD G N  +   +A
Sbjct: 376  TVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVA 435

Query: 1020 SPQPGVFAIDRALG-------VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071
               P         G        L     L   + ++ T+ + A D G  P ++   L V 
Sbjct: 436  GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQ 495

Query: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS-VDS 1130
            V++  +++P   F   V +V   E+  P   + +  A        A  L YSLEP     
Sbjct: 496  VVDVNDNAP--VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAE-LVYSLEPEPAAK 552

Query: 1131 AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPT 1190
             +F I P TG I ++   D E  ++Y  +V A       LQ  +T V+V V D NDN P 
Sbjct: 553  GLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTAT-VLVNVLDCNDNDPK 611

Query: 1191 FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWV 1250
            F+       V E+      +G +T ID D G+N Q+   +  D   F +   TG +++ +
Sbjct: 612  FMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSL 671

Query: 1251 ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
            + DRE +  +   +   D G PPR+A + V ++V D NDN P+     P    H  +   
Sbjct: 672  SFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYI--TAPSNTSHKLLTPQ 729

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
              +   V+ V A+D D G NAE+ YS++   P  L
Sbjct: 730  TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 764



 Score =  167 bits (423), Expect = 6e-41
 Identities = 171/675 (25%), Positives = 293/675 (43%), Gaps = 80/675 (11%)

Query: 515  GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
            GSP L   +   + V D+ND  P F+      ++ E    G++     ASD D       
Sbjct: 147  GSPRLLEGQ---IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD------- 196

Query: 575  WLRYTVVQLSAPCNLGSLQSKMVHTAE--CGPSFAIDSESGA--ISTIRTLDREVQEAVE 630
                     + P  + S + +    A+   G   A D E     +  +  LDRE  ++ +
Sbjct: 197  ---------AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD 247

Query: 631  LKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDA 690
            L +  QD G PP +++ L+ +TV D NDN P F R  Y A ++E++P+GH  +QV A+D+
Sbjct: 248  LTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDS 307

Query: 691  DSGLYGFIEYSLYDGFLSYEAPQA----FRIDPHDGQICVSQDIDRERDPATYDLLVEAK 746
            D G    IEY+       ++AP+      R+D + G I V   +DRE D +T    V AK
Sbjct: 308  DQGANAEIEYTF------HQAPEVVRRLLRLDRNTGLITVQGPVDRE-DLSTLRFSVLAK 360

Query: 747  DGG--GLSAQAFVRVDLEDVNDNHP--------VFNPSTYVTSISDETQPGTEIINVLAT 796
            D G    SA+A V V ++D+NDN P        +      + +IS++    T +  V  +
Sbjct: 361  DRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVS 420

Query: 797  DQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------IIYLTLPLSHLESTTLSLMVSAQ 849
            D+D G    V   ++ G+V       S TG        +  T PL + +    ++ + A 
Sbjct: 421  DRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 479

Query: 850  DGGG---------LTAVINADVTIHIFQTTLAPAEF-ERPKYTFLVYEDVPEDSPIGTVK 899
            D G             V++ +    +F  ++    F E  K   ++ E    D+  G   
Sbjct: 480  DSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG--- 536

Query: 900  AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPA 959
                 +++E ++         G F+I P  G I+ +  LD E +    L V A    +P+
Sbjct: 537  -----SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS 591

Query: 960  CSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI 1018
               T  V + V+D NDN P F+ +     + +  P  + + +    D D G N  ++ S+
Sbjct: 592  LQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV 651

Query: 1019 ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKRE 1077
                 G F I    G +  + S    +Q   T  L+A D GV P++A + +T+ V+++ +
Sbjct: 652  EQDN-GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDEND 710

Query: 1078 HSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG---PQRAASPLRYSLEPSVDSAMFG 1134
            ++P  T           + L+P T++ +T +            + L YS+       +F 
Sbjct: 711  NAPYITAPSNTSH----KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQ 766

Query: 1135 IRPYTGWIYLRRQFD 1149
            I  ++G I L ++ +
Sbjct: 767  IGSHSGAITLEKEIE 781



 Score =  134 bits (336), Expect = 8e-31
 Identities = 158/559 (28%), Positives = 223/559 (39%), Gaps = 89/559 (15%)

Query: 121 DTGIIRTARRLDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQL 174
           +TG+I     +DRE      F V A   G     A  QV + V D+ND++P   +  + L
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGL 394

Query: 175 --------DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
                   ++SE     TA  L    D D G       T V   D+P       FQLR  
Sbjct: 395 VTHQDGMANISEDVAEETAVALVQVSDRDEG--ENAAVTCVVAGDVP-------FQLRQA 445

Query: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
           +          GS S  +   L     LD E+   + ++I A D G P  +   S++++V
Sbjct: 446 SE--------TGSDSKKKYF-LQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQV 496

Query: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
           +D NDN PVF Q     A  E+ +PG  +  + A+D D G N  + YS+     P A   
Sbjct: 497 VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE--PAA--- 551

Query: 347 GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
                    F +   +G ++V   LDRE +  ++L V A D G+     T  V + VLD 
Sbjct: 552 ------KGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDC 605

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN P     F+  G    V E       V  V+V D D          GE      +  
Sbjct: 606 NDNDPK----FMLSGYNFSVMENMPALSPVGMVTVIDGD---------KGE------NAQ 646

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
           + LS+E   GDF +  G   G     +    DRE +  Y   L A D G PP S    + 
Sbjct: 647 VQLSVEQDNGDFVIQNG--TGTILSSLS--FDREQQSTYTFQLKAVDGGVPPRSAYVGVT 702

Query: 527 LRVADLNDQPPLF---SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
           + V D ND  P     S   +K    +    G  V  V+A D D   +  A L Y++   
Sbjct: 703 INVLDENDNAPYITAPSNTSHKLLTPQTRL-GETVSQVAAEDFDSGVN--AELIYSIAG- 758

Query: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL 643
             P  L                F I S SGAI+  + ++R       L V   D G+PP 
Sbjct: 759 GNPYGL----------------FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPR 802

Query: 644 SATCLVSITVDDVNDNEPI 662
             T LV + V++   N  +
Sbjct: 803 YGTALVHLYVNETLANRTL 821



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 62/239 (25%), Positives = 94/239 (39%), Gaps = 36/239 (15%)

Query: 66  LFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGII 125
           L     SV E +P  + VG +   +    + E +   LS + D+     DF +   TG I
Sbjct: 614 LSGYNFSVMENMPALSPVGMVT--VIDGDKGENAQVQLSVEQDNG----DFVIQNGTGTI 667

Query: 126 RTARRLDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSEL 179
            ++   DRE++  Y+F    + G V      V V I V D ND++P              
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYIT----------- 716

Query: 180 SPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLP-G 238
           +P  T+ +L     P   L  T      +  D     +G   +L Y   G  P  L   G
Sbjct: 717 APSNTSHKLLT---PQTRLGETVSQVAAEDFD-----SGVNAELIYSIAGGNPYGLFQIG 768

Query: 239 SSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFE 297
           S S      + L + ++R     HRL ++  D G+P R G   V L V +   N  + E
Sbjct: 769 SHSGA----ITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  271 bits (692), Expect = 4e-72
 Identities = 237/754 (31%), Positives = 351/754 (46%), Gaps = 111/754 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           ++ LL+   LW   G  +QL     +V E     T VG+I   L     +  +  F +  
Sbjct: 1   MIVLLLFALLWMVEGVFSQLH---YTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVP 57

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVV-------QVEIRVND 159
           +  +P LD   ++ +TG++    ++DRE+    S      L   +       QVEI V D
Sbjct: 58  NSRTPYLD---LNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLD 114

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND+ P FP   L +++SE + PGT F L  A DPD G  S + Y +   S         
Sbjct: 115 INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS--------- 165

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG------- 272
           +F L  +T G        G+       +LVL + LDRE+ A HR  + A DGG       
Sbjct: 166 YFSLDVQTQGD-------GNRFA----ELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGE 214

Query: 273 ------------RPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRA 320
                       + +RTG   + +RVLD NDN P F+Q  Y  ++ E++ PG  V ++ A
Sbjct: 215 GGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNA 274

Query: 321 TDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQ 380
           TD D G NG V YS  +   P A            F +   +G + V   LD E    +Q
Sbjct: 275 TDPDEGQNGEVVYSFSSHISPRARE---------LFGLSPRTGRLEVSGELDYEESPVYQ 325

Query: 381 LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVS 440
           + V+A+D G     A  +V + VLD NDN P I    + E     VSEGA PG  VA  S
Sbjct: 326 VYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA----VSEGAAPGTVVALFS 381

Query: 441 VSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE 500
           V+D D   E+  +   EL   LGD  +   L+    ++          + +  E PLDRE
Sbjct: 382 VTDRDS--EENGQVQCEL---LGD--VPFRLKSSFKNY----------YTIVTEAPLDRE 424

Query: 501 SRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMW 560
           + D Y L +VA D G P LST +++ ++V+D+ND  P FSQ  Y   V+E   PG  +  
Sbjct: 425 AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA 484

Query: 561 VSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT 620
           VSA+D DE    +A L Y++++         +Q   V T       +I+SE+G +  +R+
Sbjct: 485 VSATDRDEGA--NAQLAYSILEC-------QIQGMSVFT-----YVSINSENGYLYALRS 530

Query: 621 LDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVNDNEPIFWRQV--YNATIAEH-- 675
            D E  +    +V A+D G P  L+    V+I + D NDN P     +   N T A    
Sbjct: 531 FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVL 590

Query: 676 ---APVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 732
              A  G+   +V A DAD G    + YS+  G         FR+D   G++  ++ +  
Sbjct: 591 PRSAEPGYLLTRVAAVDADDGENARLTYSIVRG----NEMNLFRMDWRTGELRTARRVPA 646

Query: 733 ERDP-ATYDLLVEAKDGG--GLSAQAFVRVDLED 763
           +RDP   Y+L++E +D G   LS+ A + V L D
Sbjct: 647 KRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  186 bits (472), Expect = 1e-46
 Identities = 194/723 (26%), Positives = 291/723 (40%), Gaps = 98/723 (13%)

Query: 197 GLFSTQGYTLVQPSD-------LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLV 249
           G+FS   YT+ +  +       + +D      +L  R    +P+   P     LE   L 
Sbjct: 15  GVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLY 74

Query: 250 LLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
           +  ++DRE+         L +E +         L  VE+ VLD NDNPP F + +    +
Sbjct: 75  VNEKIDREQICKQSPSCVLHLEVF---LENPLELFQVEIEVLDINDNPPSFPEPDLTVEI 131

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E A PG       A D D+G N    Y +               GD   FA   L    
Sbjct: 132 SESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQ--TQGDGNRFAELVLE--- 186

Query: 366 RVWRPLDREAQAWHQLVVEARDGGA-------------------EPEVATVRVSIAVLDV 406
              +PLDRE QA H+ V+ A DGG                    +    T  ++I VLD 
Sbjct: 187 ---KPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDS 243

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN PA      T      + E + PG  V +++ +D D          G+ G  +   S
Sbjct: 244 NDNVPAFDQPVYT----VSLPENSPPGTLVIQLNATDPD---------EGQNGEVVYSFS 290

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
             +S    E     L G  P    L V G LD E   +Y++ + A D G   +     +L
Sbjct: 291 SHISPRARE-----LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           +RV D ND  P  S    K +VSE AAPGTVV   S +D D   +               
Sbjct: 346 VRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEEN--------------- 390

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPL 643
              G +Q +++        F + S      TI T   LDRE  ++  L VVA+D GEP L
Sbjct: 391 ---GQVQCELLGDVP----FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443

Query: 644 SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
           S +  + + V DVNDN P F + VY+  + E+   G     V+A+D D G    + YS+ 
Sbjct: 444 STSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSIL 503

Query: 704 DGFLSYEAPQAF-RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRV 759
           +  +   +   +  I+  +G +   +  D E+    +   VEA+D G    L+  A V +
Sbjct: 504 ECQIQGMSVFTYVSINSENGYLYALRSFDYEQ-LKDFSFQVEARDAGSPQALAGNATVNI 562

Query: 760 DLEDVNDNHPVF-------NPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIP 812
            + D NDN P         N +     +    +PG  +  V A D D G    + Y ++ 
Sbjct: 563 LIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVR 622

Query: 813 GNVSSLFTIDSTTGIIYLT--LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTT 870
           GN  +LF +D  TG +     +P          L++  +D G       A + + +    
Sbjct: 623 GNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGA 682

Query: 871 LAP 873
           + P
Sbjct: 683 VEP 685



 Score =  150 bits (379), Expect = 8e-36
 Identities = 151/586 (25%), Positives = 248/586 (42%), Gaps = 69/586 (11%)

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            V +++ D+NDN P F        IS+   PGT      A D D G      YE+ P   +
Sbjct: 108  VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITP---N 164

Query: 817  SLFTIDSTT-------GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN---------- 859
            S F++D  T         + L  PL   +      +++A DGGG   V            
Sbjct: 165  SYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGL 224

Query: 860  ---------ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP- 909
                     A +TI +  +      F++P YT      +PE+SP GT+  +  LN+++P 
Sbjct: 225  PPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTV----SLPENSPPGTLVIQ--LNATDPD 278

Query: 910  ------IFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPA 959
                  + Y  SS         F + PR G +     LD+E  PV  + VQA+ LG    
Sbjct: 279  EGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 338

Query: 960  CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 1019
             +  +V + V+D NDN P    ++ +  +S+   PGT + L    DRDS  NG ++  + 
Sbjct: 339  PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 398

Query: 1020 SPQPGVFAIDRALG---VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEK 1075
               P  F +  +      +     L        TLT+ A D+G    +    + V V + 
Sbjct: 399  GDVP--FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDV 456

Query: 1076 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA----HPLGPQRAASPLRYSLEPSVDSA 1131
             +++P   F   VY V V+E+  P   +    A         Q A S L   ++      
Sbjct: 457  NDNAPR--FSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFT 514

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 1191
               I    G++Y  R FDYE  + ++F+V A           + TV + + D+NDN+P  
Sbjct: 515  YVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAI 574

Query: 1192 LHDVLFLK-------VEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPN 1242
            +  +           +  S  P  ++ ++ A+D D G+N +L Y ++  ++   F+M+  
Sbjct: 575  VAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWR 634

Query: 1243 TGEL--INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
            TGEL     V   R+ +  +E+ + V D G PP ++T  + V + D
Sbjct: 635  TGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  130 bits (327), Expect = 9e-30
 Identities = 120/406 (29%), Positives = 175/406 (43%), Gaps = 42/406 (10%)

Query: 964  EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
            +V I V+D+NDN P+F      + IS++  PGT   L  A D D G N L  Y I     
Sbjct: 107  QVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS- 165

Query: 1024 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAED----------------QGV 1060
              F++D            L L   L   +Q      L A D                 G+
Sbjct: 166  -YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGL 224

Query: 1061 HPQ-----AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA-HPLGPQ 1114
             PQ      ALL + V ++  ++ P+  F+  VY V + E+  P T ++Q  A  P   Q
Sbjct: 225  PPQQQRTGTALLTIRV-LDSNDNVPA--FDQPVYTVSLPENSPPGTLVIQLNATDPDEGQ 281

Query: 1115 RAASPLRYSLEPSVDSA-MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
                   +S   S  +  +FG+ P TG + +  + DYE +  Y   V A       +   
Sbjct: 282  NGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVP-A 340

Query: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
               V+VRV D NDN+P      +   V E   P  V+   +  D DS +NGQ+   LL D
Sbjct: 341  HCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGD 400

Query: 1234 GKFFKMNP--NTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
              F   +   N   ++    LDRE    + +TV+  DRG P  + + ++ V V+D+NDN 
Sbjct: 401  VPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNA 460

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            P F Q +      V V E       +  V A D DEG NA++ YS+
Sbjct: 461  PRFSQPV----YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502



 Score =  130 bits (326), Expect = 1e-29
 Identities = 152/586 (25%), Positives = 241/586 (41%), Gaps = 70/586 (11%)

Query: 538  LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            +FSQ HY  +V E    GT V     + A++ G D       + +LSA        S+  
Sbjct: 16   VFSQLHY--TVQEEQEHGTFV----GNIAEDLGLD-------ITKLSARGFQTVPNSRT- 61

Query: 598  HTAECGPSFAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                  P   ++ E+G +     +DRE   +++    +  +   E PL     V I V D
Sbjct: 62   ------PYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELF-QVEIEVLD 114

Query: 656  VNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
            +NDN P F        I+E A  G  F   +A D D G     +Y +          Q  
Sbjct: 115  INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQ 174

Query: 716  RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---------------------LSAQ 754
                   ++ + + +DRE+  A +  ++ A DGGG                      +  
Sbjct: 175  GDGNRFAELVLEKPLDREQQ-AVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGT 233

Query: 755  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---I 811
            A + + + D NDN P F+   Y  S+ + + PGT +I + ATD D G  G V Y     I
Sbjct: 234  ALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHI 293

Query: 812  PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL 871
                  LF +   TG + ++  L + ES    + V A+D G      +  V + +     
Sbjct: 294  SPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLD--- 350

Query: 872  APAEFERPKYTF-LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
              A    P+ +F  V E V E +  GTV A   +   +         +L G      +  
Sbjct: 351  --ANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSS 408

Query: 931  -----TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSD 984
                 TI T  PLD E      LTV A+    PA S+++ + + V DVNDN P F +   
Sbjct: 409  FKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVY 468

Query: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---PGVF---AIDRALGVLFLN 1038
            ++ +++   PG  +Y   A DRD G N  + YSI   Q     VF   +I+   G L+  
Sbjct: 469  DVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYAL 528

Query: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV---VIEKREHSPS 1081
             S    + ++ +  + A D G  PQA     TV   ++++ +++P+
Sbjct: 529  RSFDYEQLKDFSFQVEARDAG-SPQALAGNATVNILIVDQNDNAPA 573



 Score =  117 bits (292), Expect = 1e-25
 Identities = 163/635 (25%), Positives = 254/635 (40%), Gaps = 97/635 (15%)

Query: 779  SISDETQPGTEIINVLATDQDSGIYGTV----AYELIPGNVSSLFTIDSTTGIIYLTLPL 834
            ++ +E + GT + N+    +D G+  T      ++ +P + +    ++  TG++Y+   +
Sbjct: 23   TVQEEQEHGTFVGNIA---EDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKI 79

Query: 835  SHLE------STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 888
               +      S  L L V  ++   L       V I +      P  F  P  T  + E 
Sbjct: 80   DREQICKQSPSCVLHLEVFLENPLELF-----QVEIEVLDINDNPPSFPEPDLTVEISES 134

Query: 889  VPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP-------RLGTIRTRKPLDH 940
                +      A +P + ++    Y I+       FS+         R   +   KPLD 
Sbjct: 135  ATPGTRFPLESAFDPDVGTNSLRDYEITPNSY---FSLDVQTQGDGNRFAELVLEKPLDR 191

Query: 941  ETQPV--VVLTVQ---------------AQLGSAPACSSTE---VNITVMDVNDNHPAFL 980
            E Q V   VLT                    G  P    T    + I V+D NDN PAF 
Sbjct: 192  EQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFD 251

Query: 981  RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS---PQPG-VFAIDRALGVLF 1036
            +    + + + +PPGT +    A D D G+NG + YS +S   P+   +F +    G L 
Sbjct: 252  QPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLE 311

Query: 1037 LNGSLGAGEQRELTLTLRAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSE 1095
            ++G L   E     + ++A+D G +   A   VL  V++  +++P  +F  +  +  VSE
Sbjct: 312  VSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTV--KEAVSE 369

Query: 1096 SLSPMTQML-------------QTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
              +P T +              Q Q   LG       + + L+ S  +       YT  I
Sbjct: 370  GAAPGTVVALFSVTDRDSEENGQVQCELLGD------VPFRLKSSFKNY------YT--I 415

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 1202
                  D E+  +Y   V A    +  L + S ++ V+V D NDN+P F   V  + V E
Sbjct: 416  VTEAPLDREAGDSYTLTVVARDRGEPAL-STSKSIQVQVSDVNDNAPRFSQPVYDVYVTE 474

Query: 1203 SPVPQGVIGKITAIDMDSGKNGQLLYFLL-------SDGKFFKMNPNTGELINWVALDRE 1255
            + VP   I  ++A D D G N QL Y +L       S   +  +N   G L    + D E
Sbjct: 475  NNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYE 534

Query: 1256 HRGHHEMTVLVTDRGSPPRNATMA-VYVSVTDINDNRPFFPQCLPGKE----LHVKVLEG 1310
                    V   D GSP   A  A V + + D NDN P     LPG+       V     
Sbjct: 535  QLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSA 594

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
            +P   L+T V A D D+G NA +TYS+     M L
Sbjct: 595  EP-GYLLTRVAAVDADDGENARLTYSIVRGNEMNL 628


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  271 bits (692), Expect = 4e-72
 Identities = 237/754 (31%), Positives = 351/754 (46%), Gaps = 111/754 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           ++ LL+   LW   G  +QL     +V E     T VG+I   L     +  +  F +  
Sbjct: 1   MIVLLLFALLWMVEGVFSQLH---YTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVP 57

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVV-------QVEIRVND 159
           +  +P LD   ++ +TG++    ++DRE+    S      L   +       QVEI V D
Sbjct: 58  NSRTPYLD---LNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLD 114

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND+ P FP   L +++SE + PGT F L  A DPD G  S + Y +   S         
Sbjct: 115 INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS--------- 165

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG------- 272
           +F L  +T G        G+       +LVL + LDRE+ A HR  + A DGG       
Sbjct: 166 YFSLDVQTQGD-------GNRFA----ELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGE 214

Query: 273 ------------RPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRA 320
                       + +RTG   + +RVLD NDN P F+Q  Y  ++ E++ PG  V ++ A
Sbjct: 215 GGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNA 274

Query: 321 TDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQ 380
           TD D G NG V YS  +   P A            F +   +G + V   LD E    +Q
Sbjct: 275 TDPDEGQNGEVVYSFSSHISPRARE---------LFGLSPRTGRLEVSGELDYEESPVYQ 325

Query: 381 LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVS 440
           + V+A+D G     A  +V + VLD NDN P I    + E     VSEGA PG  VA  S
Sbjct: 326 VYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA----VSEGAAPGTVVALFS 381

Query: 441 VSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE 500
           V+D D   E+  +   EL   LGD  +   L+    ++          + +  E PLDRE
Sbjct: 382 VTDRDS--EENGQVQCEL---LGD--VPFRLKSSFKNY----------YTIVTEAPLDRE 424

Query: 501 SRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMW 560
           + D Y L +VA D G P LST +++ ++V+D+ND  P FSQ  Y   V+E   PG  +  
Sbjct: 425 AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA 484

Query: 561 VSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT 620
           VSA+D DE    +A L Y++++         +Q   V T       +I+SE+G +  +R+
Sbjct: 485 VSATDRDEGA--NAQLAYSILEC-------QIQGMSVFT-----YVSINSENGYLYALRS 530

Query: 621 LDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVNDNEPIFWRQV--YNATIAEH-- 675
            D E  +    +V A+D G P  L+    V+I + D NDN P     +   N T A    
Sbjct: 531 FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVL 590

Query: 676 ---APVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 732
              A  G+   +V A DAD G    + YS+  G         FR+D   G++  ++ +  
Sbjct: 591 PRSAEPGYLLTRVAAVDADDGENARLTYSIVRG----NEMNLFRMDWRTGELRTARRVPA 646

Query: 733 ERDP-ATYDLLVEAKDGG--GLSAQAFVRVDLED 763
           +RDP   Y+L++E +D G   LS+ A + V L D
Sbjct: 647 KRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  186 bits (472), Expect = 1e-46
 Identities = 194/723 (26%), Positives = 291/723 (40%), Gaps = 98/723 (13%)

Query: 197 GLFSTQGYTLVQPSD-------LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLV 249
           G+FS   YT+ +  +       + +D      +L  R    +P+   P     LE   L 
Sbjct: 15  GVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLY 74

Query: 250 LLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
           +  ++DRE+         L +E +         L  VE+ VLD NDNPP F + +    +
Sbjct: 75  VNEKIDREQICKQSPSCVLHLEVF---LENPLELFQVEIEVLDINDNPPSFPEPDLTVEI 131

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E A PG       A D D+G N    Y +               GD   FA   L    
Sbjct: 132 SESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQ--TQGDGNRFAELVLE--- 186

Query: 366 RVWRPLDREAQAWHQLVVEARDGGA-------------------EPEVATVRVSIAVLDV 406
              +PLDRE QA H+ V+ A DGG                    +    T  ++I VLD 
Sbjct: 187 ---KPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDS 243

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN PA      T      + E + PG  V +++ +D D          G+ G  +   S
Sbjct: 244 NDNVPAFDQPVYT----VSLPENSPPGTLVIQLNATDPD---------EGQNGEVVYSFS 290

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
             +S    E     L G  P    L V G LD E   +Y++ + A D G   +     +L
Sbjct: 291 SHISPRARE-----LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           +RV D ND  P  S    K +VSE AAPGTVV   S +D D   +               
Sbjct: 346 VRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEEN--------------- 390

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPL 643
              G +Q +++        F + S      TI T   LDRE  ++  L VVA+D GEP L
Sbjct: 391 ---GQVQCELLGDVP----FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443

Query: 644 SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
           S +  + + V DVNDN P F + VY+  + E+   G     V+A+D D G    + YS+ 
Sbjct: 444 STSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSIL 503

Query: 704 DGFLSYEAPQAF-RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LSAQAFVRV 759
           +  +   +   +  I+  +G +   +  D E+    +   VEA+D G    L+  A V +
Sbjct: 504 ECQIQGMSVFTYVSINSENGYLYALRSFDYEQ-LKDFSFQVEARDAGSPQALAGNATVNI 562

Query: 760 DLEDVNDNHPVF-------NPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIP 812
            + D NDN P         N +     +    +PG  +  V A D D G    + Y ++ 
Sbjct: 563 LIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVR 622

Query: 813 GNVSSLFTIDSTTGIIYLT--LPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTT 870
           GN  +LF +D  TG +     +P          L++  +D G       A + + +    
Sbjct: 623 GNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGA 682

Query: 871 LAP 873
           + P
Sbjct: 683 VEP 685



 Score =  150 bits (379), Expect = 8e-36
 Identities = 151/586 (25%), Positives = 248/586 (42%), Gaps = 69/586 (11%)

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            V +++ D+NDN P F        IS+   PGT      A D D G      YE+ P   +
Sbjct: 108  VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITP---N 164

Query: 817  SLFTIDSTT-------GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN---------- 859
            S F++D  T         + L  PL   +      +++A DGGG   V            
Sbjct: 165  SYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGL 224

Query: 860  ---------ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP- 909
                     A +TI +  +      F++P YT      +PE+SP GT+  +  LN+++P 
Sbjct: 225  PPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTV----SLPENSPPGTLVIQ--LNATDPD 278

Query: 910  ------IFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPA 959
                  + Y  SS         F + PR G +     LD+E  PV  + VQA+ LG    
Sbjct: 279  EGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 338

Query: 960  CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 1019
             +  +V + V+D NDN P    ++ +  +S+   PGT + L    DRDS  NG ++  + 
Sbjct: 339  PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 398

Query: 1020 SPQPGVFAIDRALG---VLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEK 1075
               P  F +  +      +     L        TLT+ A D+G    +    + V V + 
Sbjct: 399  GDVP--FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDV 456

Query: 1076 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA----HPLGPQRAASPLRYSLEPSVDSA 1131
             +++P   F   VY V V+E+  P   +    A         Q A S L   ++      
Sbjct: 457  NDNAPR--FSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFT 514

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 1191
               I    G++Y  R FDYE  + ++F+V A           + TV + + D+NDN+P  
Sbjct: 515  YVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAI 574

Query: 1192 LHDVLFLK-------VEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPN 1242
            +  +           +  S  P  ++ ++ A+D D G+N +L Y ++  ++   F+M+  
Sbjct: 575  VAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWR 634

Query: 1243 TGEL--INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTD 1286
            TGEL     V   R+ +  +E+ + V D G PP ++T  + V + D
Sbjct: 635  TGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  130 bits (327), Expect = 9e-30
 Identities = 120/406 (29%), Positives = 175/406 (43%), Gaps = 42/406 (10%)

Query: 964  EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
            +V I V+D+NDN P+F      + IS++  PGT   L  A D D G N L  Y I     
Sbjct: 107  QVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS- 165

Query: 1024 GVFAID-------RALGVLFLNGSLGAGEQRELTLTLRAED----------------QGV 1060
              F++D            L L   L   +Q      L A D                 G+
Sbjct: 166  -YFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGL 224

Query: 1061 HPQ-----AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA-HPLGPQ 1114
             PQ      ALL + V ++  ++ P+  F+  VY V + E+  P T ++Q  A  P   Q
Sbjct: 225  PPQQQRTGTALLTIRV-LDSNDNVPA--FDQPVYTVSLPENSPPGTLVIQLNATDPDEGQ 281

Query: 1115 RAASPLRYSLEPSVDSA-MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
                   +S   S  +  +FG+ P TG + +  + DYE +  Y   V A       +   
Sbjct: 282  NGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVP-A 340

Query: 1174 STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
               V+VRV D NDN+P      +   V E   P  V+   +  D DS +NGQ+   LL D
Sbjct: 341  HCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGD 400

Query: 1234 GKFFKMNP--NTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
              F   +   N   ++    LDRE    + +TV+  DRG P  + + ++ V V+D+NDN 
Sbjct: 401  VPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNA 460

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
            P F Q +      V V E       +  V A D DEG NA++ YS+
Sbjct: 461  PRFSQPV----YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502



 Score =  130 bits (326), Expect = 1e-29
 Identities = 152/586 (25%), Positives = 241/586 (41%), Gaps = 70/586 (11%)

Query: 538  LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            +FSQ HY  +V E    GT V     + A++ G D       + +LSA        S+  
Sbjct: 16   VFSQLHY--TVQEEQEHGTFV----GNIAEDLGLD-------ITKLSARGFQTVPNSRT- 61

Query: 598  HTAECGPSFAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                  P   ++ E+G +     +DRE   +++    +  +   E PL     V I V D
Sbjct: 62   ------PYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELF-QVEIEVLD 114

Query: 656  VNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAF 715
            +NDN P F        I+E A  G  F   +A D D G     +Y +          Q  
Sbjct: 115  INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQ 174

Query: 716  RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---------------------LSAQ 754
                   ++ + + +DRE+  A +  ++ A DGGG                      +  
Sbjct: 175  GDGNRFAELVLEKPLDREQQ-AVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGT 233

Query: 755  AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL---I 811
            A + + + D NDN P F+   Y  S+ + + PGT +I + ATD D G  G V Y     I
Sbjct: 234  ALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHI 293

Query: 812  PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL 871
                  LF +   TG + ++  L + ES    + V A+D G      +  V + +     
Sbjct: 294  SPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLD--- 350

Query: 872  APAEFERPKYTF-LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
              A    P+ +F  V E V E +  GTV A   +   +         +L G      +  
Sbjct: 351  --ANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSS 408

Query: 931  -----TIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSD 984
                 TI T  PLD E      LTV A+    PA S+++ + + V DVNDN P F +   
Sbjct: 409  FKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVY 468

Query: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---PGVF---AIDRALGVLFLN 1038
            ++ +++   PG  +Y   A DRD G N  + YSI   Q     VF   +I+   G L+  
Sbjct: 469  DVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYAL 528

Query: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV---VIEKREHSPS 1081
             S    + ++ +  + A D G  PQA     TV   ++++ +++P+
Sbjct: 529  RSFDYEQLKDFSFQVEARDAG-SPQALAGNATVNILIVDQNDNAPA 573



 Score =  117 bits (292), Expect = 1e-25
 Identities = 163/635 (25%), Positives = 254/635 (40%), Gaps = 97/635 (15%)

Query: 779  SISDETQPGTEIINVLATDQDSGIYGTV----AYELIPGNVSSLFTIDSTTGIIYLTLPL 834
            ++ +E + GT + N+    +D G+  T      ++ +P + +    ++  TG++Y+   +
Sbjct: 23   TVQEEQEHGTFVGNIA---EDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKI 79

Query: 835  SHLE------STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYED 888
               +      S  L L V  ++   L       V I +      P  F  P  T  + E 
Sbjct: 80   DREQICKQSPSCVLHLEVFLENPLELF-----QVEIEVLDINDNPPSFPEPDLTVEISES 134

Query: 889  VPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP-------RLGTIRTRKPLDH 940
                +      A +P + ++    Y I+       FS+         R   +   KPLD 
Sbjct: 135  ATPGTRFPLESAFDPDVGTNSLRDYEITPNSY---FSLDVQTQGDGNRFAELVLEKPLDR 191

Query: 941  ETQPV--VVLTVQ---------------AQLGSAPACSSTE---VNITVMDVNDNHPAFL 980
            E Q V   VLT                    G  P    T    + I V+D NDN PAF 
Sbjct: 192  EQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFD 251

Query: 981  RTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS---PQPG-VFAIDRALGVLF 1036
            +    + + + +PPGT +    A D D G+NG + YS +S   P+   +F +    G L 
Sbjct: 252  QPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLE 311

Query: 1037 LNGSLGAGEQRELTLTLRAEDQGVHPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSE 1095
            ++G L   E     + ++A+D G +   A   VL  V++  +++P  +F  +  +  VSE
Sbjct: 312  VSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTV--KEAVSE 369

Query: 1096 SLSPMTQML-------------QTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
              +P T +              Q Q   LG       + + L+ S  +       YT  I
Sbjct: 370  GAAPGTVVALFSVTDRDSEENGQVQCELLGD------VPFRLKSSFKNY------YT--I 415

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 1202
                  D E+  +Y   V A    +  L + S ++ V+V D NDN+P F   V  + V E
Sbjct: 416  VTEAPLDREAGDSYTLTVVARDRGEPAL-STSKSIQVQVSDVNDNAPRFSQPVYDVYVTE 474

Query: 1203 SPVPQGVIGKITAIDMDSGKNGQLLYFLL-------SDGKFFKMNPNTGELINWVALDRE 1255
            + VP   I  ++A D D G N QL Y +L       S   +  +N   G L    + D E
Sbjct: 475  NNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYE 534

Query: 1256 HRGHHEMTVLVTDRGSPPRNATMA-VYVSVTDINDNRPFFPQCLPGKE----LHVKVLEG 1310
                    V   D GSP   A  A V + + D NDN P     LPG+       V     
Sbjct: 535  QLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSA 594

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPL 1345
            +P   L+T V A D D+G NA +TYS+     M L
Sbjct: 595  EP-GYLLTRVAAVDADDGENARLTYSIVRGNEMNL 628


>gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  268 bits (685), Expect = 3e-71
 Identities = 224/738 (30%), Positives = 334/738 (45%), Gaps = 107/738 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           LL L + + L A +G      N+  SV E     + VG+I   L    Q+   G      
Sbjct: 15  LLCLSLELLLEAGAG------NIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVS 68

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVND 159
               PL   F ++P +G + TARR+DRE     S         +V+       VE+ + D
Sbjct: 69  RGRMPL---FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIID 125

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P+F L+ L+  ++E++ PGT   LP   D D G+ S Q Y L          + P
Sbjct: 126 INDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---------SSNP 176

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  +           G+  P  P ++VL   LDREE A H L + A DGG P R+G 
Sbjct: 177 HFSLDVQQ----------GADGPQHP-EMVLQSPLDREEEAVHHLILTASDGGEPVRSGT 225

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV---- 335
           L + ++V+D NDNPP F Q +Y   V E+   G ++  V ATD D G NG V YS     
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD 285

Query: 336 -RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
            R  Q+               F ++  +G +    PLD E    + + V+A+DG     +
Sbjct: 286 HRVAQI---------------FRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LM 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           A V+V I VLDVNDN P + +  +T      V E   PG  +A +SV D D         
Sbjct: 329 AKVKVLIKVLDVNDNAPEVTITSVT----TAVPENFPPGTIIALISVHDQDS-------- 376

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                   GD   +     G   F  L       + L  E  LDRE    Y + + A D 
Sbjct: 377 --------GDNGYTTCFIPGNLPFK-LEKLVDNYYRLVTERTLDRELISGYNITITAIDQ 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           G+P LSTE  + L V D+ND  P+F Q  Y A + E    G  +  V A D D   +++A
Sbjct: 428 GTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLD--SNENA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y++++              +  A      +I+S++G +  +R+ D E    ++LKV+
Sbjct: 486 QITYSLIE------------DTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVM 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVY---NATIAEHAPV----GHCFLQVTA 687
           A+D G+PPLS+   +S+ + D NDN P           +T  E AP+    G+   +V A
Sbjct: 534 ARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVA 593

Query: 688 SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
            D DSG   ++ Y L    L    P  F +  H G++  ++ +  +RD     L+V  +D
Sbjct: 594 VDRDSGQNAWLSYRL----LKASEPGLFSVGLHTGEVRTARAL-LDRDALKQSLVVAVQD 648

Query: 748 GG--GLSAQAFVRVDLED 763
            G   LSA   + V + D
Sbjct: 649 HGQPPLSATVTLTVAVAD 666



 Score =  182 bits (461), Expect = 2e-45
 Identities = 157/578 (27%), Positives = 262/578 (45%), Gaps = 59/578 (10%)

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
            + + D+ND  P F  +  +  ++E   PGT V      D D                   
Sbjct: 121  VEIIDINDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLD------------------- 161

Query: 587  CNLGSLQSKMVHTAECGPSFAIDSESGA-------ISTIRTLDREVQEAVELKVVAQDLG 639
              + SLQS  + +    P F++D + GA       +     LDRE +    L + A D G
Sbjct: 162  VGMNSLQSYQLSS---NPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGG 218

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
            EP  S T  + I V D NDN P F +  Y+  + E+ P+G   L V A+D D G  G + 
Sbjct: 219  EPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVT 278

Query: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRV 759
            YS ++  + +   Q FR+D + G+I   + +D E +   Y + V+A+DG GL A+  V +
Sbjct: 279  YSFHN--VDHRVAQIFRLDSYTGEISNKEPLDFE-EYKMYSMEVQAQDGAGLMAKVKVLI 335

Query: 760  DLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF 819
             + DVNDN P    ++  T++ +   PGT I  +   DQDSG  G      IPGN+   F
Sbjct: 336  KVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTC-FIPGNLP--F 392

Query: 820  TIDSTTGIIYLTLPLSHLESTTLS---LMVSAQDGGGLTAVINADVTIHIFQTTL---AP 873
             ++      Y  +    L+   +S   + ++A D G  T  ++ +  I +  T +   +P
Sbjct: 393  KLEKLVDNYYRLVTERTLDRELISGYNITITAIDQG--TPALSTETHISLLVTDINDNSP 450

Query: 874  AEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFY-----RISSGDLGGKFSIHP 927
              F +  Y+  + E+ P  + I +V+A +   N +  I Y      I    L    SI+ 
Sbjct: 451  V-FHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRT---- 982
              G +   +  D+E    + L V A+  G  P  S+  +++ ++D NDN P  L      
Sbjct: 510  DTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPT 569

Query: 983  --SDEIRISQ-TTPPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLN 1038
              S  + ++  +  PG  +    A DRDSG+N  + Y  + + +PG+F++    G +   
Sbjct: 570  DGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA 629

Query: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKR 1076
             +L   +  + +L +  +D G  P +A + LTV +  R
Sbjct: 630  RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADR 667



 Score =  168 bits (426), Expect = 3e-41
 Identities = 169/612 (27%), Positives = 272/612 (44%), Gaps = 60/612 (9%)

Query: 715  FRIDPHDGQICVSQDIDRERDPA-------TYDLLVEAKDGGGLSAQAF-VRVDLEDVND 766
            F ++P  G +  ++ IDRE   A       ++++LVE K       + F V V++ D+ND
Sbjct: 75   FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDK------MKLFPVEVEIIDIND 128

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
            N P F        +++ T PGT +      D D G+    +Y+L   + +  F++D   G
Sbjct: 129  NTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---SSNPHFSLDVQQG 185

Query: 827  I-------IYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
                    + L  PL   E     L+++A DGG         + I +      P  F + 
Sbjct: 186  ADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQA 245

Query: 880  KYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGD--LGGKFSIHPRLGTIRTRK 936
            +Y   V E+VP  + +  V A +P   ++  + Y   + D  +   F +    G I  ++
Sbjct: 246  QYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKE 305

Query: 937  PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            PLD E   +  + VQAQ G A   +  +V I V+DVNDN P    TS    + +  PPGT
Sbjct: 306  PLDFEEYKMYSMEVQAQDG-AGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGT 364

Query: 997  ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLF-------LNGSLGAGEQREL 1049
             + L    D+DSG NG     I    P  F +++ +   +       L+  L +G     
Sbjct: 365  IIALISVHDQDSGDNGYTTCFIPGNLP--FKLEKLVDNYYRLVTERTLDRELISG----Y 418

Query: 1050 TLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
             +T+ A DQG    +    +++++ +  ++SP   F    Y   + E+      +   +A
Sbjct: 419  NITITAIDQGTPALSTETHISLLVTDINDNSP--VFHQDSYSAYIPENNPRGASIFSVRA 476

Query: 1109 HPLGPQRAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
            H L     A      +E ++     SA   I   TG +Y  R FDYE  +    +V A  
Sbjct: 477  HDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARD 536

Query: 1165 PEDGFL-QNVSTTVIVRVWDENDNSPTFLHDVL----FLKVEESPV---PQGVIGKITAI 1216
              D  L  NVS ++   + D+NDN+P  L+  L       VE +P+   P  ++ K+ A+
Sbjct: 537  SGDPPLSSNVSLSLF--LLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAV 594

Query: 1217 DMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR 1274
            D DSG+N  L Y LL  S+   F +  +TGE+    AL         + V V D G PP 
Sbjct: 595  DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654

Query: 1275 NATMAVYVSVTD 1286
            +AT+ + V+V D
Sbjct: 655  SATVTLTVAVAD 666



 Score =  140 bits (352), Expect = 1e-32
 Identities = 123/437 (28%), Positives = 203/437 (46%), Gaps = 42/437 (9%)

Query: 923  FSIHPRLGTIRTRKPLDHE-----TQPVVV---LTVQAQLGSAPACSSTEVNITVMDVND 974
            F+++PR G++ T + +D E     + P +V   + V+ ++   P      V + ++D+ND
Sbjct: 75   FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFP------VEVEIIDIND 128

Query: 975  NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV 1034
            N P F     E ++++ T PGT + L   +D D G N L  Y ++S     F++D   G 
Sbjct: 129  NTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPH--FSLDVQQGA 186

Query: 1035 -------LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEH 1086
                   + L   L   E+    L L A D G   ++  L + + V++  ++ P++T   
Sbjct: 187  DGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFT--Q 244

Query: 1087 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVD---SAMFGIRPYTGWI 1142
              Y + V E++   TQ+L   A    P   A+  + YS   +VD   + +F +  YTG I
Sbjct: 245  AQYHINVPENVPLGTQLLMVNA--TDPDEGANGEVTYSFH-NVDHRVAQIFRLDSYTGEI 301

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 1202
              +   D+E  + Y+  V A   +DG        V+++V D NDN+P      +   V E
Sbjct: 302  SNKEPLDFEEYKMYSMEVQA---QDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPE 358

Query: 1203 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSD--GKFFKMNPNTGELINWVALDREHRGHH 1260
            +  P  +I  I+  D DSG NG    F+  +   K  K+  N   L+    LDRE    +
Sbjct: 359  NFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGY 418

Query: 1261 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
             +T+   D+G+P  +    + + VTDINDN P F Q          + E  P    + +V
Sbjct: 419  NITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ----DSYSAYIPENNPRGASIFSV 474

Query: 1321 FAKDPDEGNNAEVTYSV 1337
             A D D   NA++TYS+
Sbjct: 475  RAHDLDSNENAQITYSL 491



 Score =  128 bits (322), Expect = 3e-29
 Identities = 121/429 (28%), Positives = 185/429 (43%), Gaps = 37/429 (8%)

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
            + PLD E + V  L + A  G  P  S T  + I V+D NDN PAF +    I + +  P
Sbjct: 197  QSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVP 256

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGV---FAIDRALGVLFLNGSLGAGEQRELT 1050
             GT L +  A D D G NG + YS  +    V   F +D   G +     L   E +  +
Sbjct: 257  LGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYS 316

Query: 1051 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
            + ++A+D G    A + VL  V++  +++P  T   +     V E+  P T +     H 
Sbjct: 317  MEVQAQD-GAGLMAKVKVLIKVLDVNDNAPEVTITSVT--TAVPENFPPGTIIALISVHD 373

Query: 1111 L-----GPQRAASP--LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
                  G      P  L + LE  VD+           +   R  D E    YN  + A 
Sbjct: 374  QDSGDNGYTTCFIPGNLPFKLEKLVDNYYR--------LVTERTLDRELISGYNITITA- 424

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
            I +     +  T + + V D NDNSP F  D     + E+      I  + A D+DS +N
Sbjct: 425  IDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNEN 484

Query: 1224 GQLLYFLLSD-------GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNA 1276
             Q+ Y L+ D         +  +N +TG L    + D E     ++ V+  D G PP ++
Sbjct: 485  AQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSS 544

Query: 1277 TMAVYVSVTDINDNRP--FFPQCLP---GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 1331
             +++ + + D NDN P   +P  LP      + +  L  +P   LVT V A D D G NA
Sbjct: 545  NVSLSLFLLDQNDNAPEILYP-ALPTDGSTGVELAPLSAEP-GYLVTKVVAVDRDSGQNA 602

Query: 1332 EVTYSVSSA 1340
             ++Y +  A
Sbjct: 603  WLSYRLLKA 611



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 18/215 (8%)

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRV---FAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
            +F + P +G +   R+ D E     +      F  + ED   +     V V + D NDN+
Sbjct: 74   LFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVED---KMKLFPVEVEIIDINDNT 130

Query: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTG---- 1244
            P F  + L  K+ E   P   +      D+D G N  L  + LS    F ++   G    
Sbjct: 131  PQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNS-LQSYQLSSNPHFSLDVQQGADGP 189

Query: 1245 ---ELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 1301
               E++    LDRE    H + +  +D G P R+ T+ +Y+ V D NDN P F Q     
Sbjct: 190  QHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQA---- 245

Query: 1302 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS 1336
            + H+ V E  P+   +  V A DPDEG N EVTYS
Sbjct: 246  QYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 12/175 (6%)

Query: 1177 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSD-- 1233
            + ++V D NDN P F      + V E+ VP G  +  + A D D G NG++ Y   +   
Sbjct: 228  IYIQVVDANDNPPAFTQAQYHINVPEN-VPLGTQLLMVNATDPDEGANGEVTYSFHNVDH 286

Query: 1234 --GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
               + F+++  TGE+ N   LD E    + M V   D       A + V + V D+NDN 
Sbjct: 287  RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNA 344

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLK 1346
            P     +    +   V E  P   ++  +   D D G+N   T  +    P  L+
Sbjct: 345  PE----VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLE 395


>gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precursor
           [Homo sapiens]
          Length = 823

 Score =  268 bits (685), Expect = 3e-71
 Identities = 224/738 (30%), Positives = 334/738 (45%), Gaps = 107/738 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           LL L + + L A +G      N+  SV E     + VG+I   L    Q+   G      
Sbjct: 15  LLCLSLELLLEAGAG------NIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVS 68

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVND 159
               PL   F ++P +G + TARR+DRE     S         +V+       VE+ + D
Sbjct: 69  RGRMPL---FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIID 125

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P+F L+ L+  ++E++ PGT   LP   D D G+ S Q Y L          + P
Sbjct: 126 INDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---------SSNP 176

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  +           G+  P  P ++VL   LDREE A H L + A DGG P R+G 
Sbjct: 177 HFSLDVQQ----------GADGPQHP-EMVLQSPLDREEEAVHHLILTASDGGEPVRSGT 225

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV---- 335
           L + ++V+D NDNPP F Q +Y   V E+   G ++  V ATD D G NG V YS     
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD 285

Query: 336 -RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
            R  Q+               F ++  +G +    PLD E    + + V+A+DG     +
Sbjct: 286 HRVAQI---------------FRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LM 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           A V+V I VLDVNDN P + +  +T      V E   PG  +A +SV D D         
Sbjct: 329 AKVKVLIKVLDVNDNAPEVTITSVT----TAVPENFPPGTIIALISVHDQDS-------- 376

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                   GD   +     G   F  L       + L  E  LDRE    Y + + A D 
Sbjct: 377 --------GDNGYTTCFIPGNLPFK-LEKLVDNYYRLVTERTLDRELISGYNITITAIDQ 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           G+P LSTE  + L V D+ND  P+F Q  Y A + E    G  +  V A D D   +++A
Sbjct: 428 GTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLD--SNENA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y++++              +  A      +I+S++G +  +R+ D E    ++LKV+
Sbjct: 486 QITYSLIE------------DTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVM 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVY---NATIAEHAPV----GHCFLQVTA 687
           A+D G+PPLS+   +S+ + D NDN P           +T  E AP+    G+   +V A
Sbjct: 534 ARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVA 593

Query: 688 SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
            D DSG   ++ Y L    L    P  F +  H G++  ++ +  +RD     L+V  +D
Sbjct: 594 VDRDSGQNAWLSYRL----LKASEPGLFSVGLHTGEVRTARAL-LDRDALKQSLVVAVQD 648

Query: 748 GG--GLSAQAFVRVDLED 763
            G   LSA   + V + D
Sbjct: 649 HGQPPLSATVTLTVAVAD 666



 Score =  182 bits (461), Expect = 2e-45
 Identities = 157/578 (27%), Positives = 262/578 (45%), Gaps = 59/578 (10%)

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
            + + D+ND  P F  +  +  ++E   PGT V      D D                   
Sbjct: 121  VEIIDINDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLD------------------- 161

Query: 587  CNLGSLQSKMVHTAECGPSFAIDSESGA-------ISTIRTLDREVQEAVELKVVAQDLG 639
              + SLQS  + +    P F++D + GA       +     LDRE +    L + A D G
Sbjct: 162  VGMNSLQSYQLSS---NPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGG 218

Query: 640  EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
            EP  S T  + I V D NDN P F +  Y+  + E+ P+G   L V A+D D G  G + 
Sbjct: 219  EPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVT 278

Query: 700  YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRV 759
            YS ++  + +   Q FR+D + G+I   + +D E +   Y + V+A+DG GL A+  V +
Sbjct: 279  YSFHN--VDHRVAQIFRLDSYTGEISNKEPLDFE-EYKMYSMEVQAQDGAGLMAKVKVLI 335

Query: 760  DLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF 819
             + DVNDN P    ++  T++ +   PGT I  +   DQDSG  G      IPGN+   F
Sbjct: 336  KVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTC-FIPGNLP--F 392

Query: 820  TIDSTTGIIYLTLPLSHLESTTLS---LMVSAQDGGGLTAVINADVTIHIFQTTL---AP 873
             ++      Y  +    L+   +S   + ++A D G  T  ++ +  I +  T +   +P
Sbjct: 393  KLEKLVDNYYRLVTERTLDRELISGYNITITAIDQG--TPALSTETHISLLVTDINDNSP 450

Query: 874  AEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFY-----RISSGDLGGKFSIHP 927
              F +  Y+  + E+ P  + I +V+A +   N +  I Y      I    L    SI+ 
Sbjct: 451  V-FHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509

Query: 928  RLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRT---- 982
              G +   +  D+E    + L V A+  G  P  S+  +++ ++D NDN P  L      
Sbjct: 510  DTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPT 569

Query: 983  --SDEIRISQ-TTPPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLN 1038
              S  + ++  +  PG  +    A DRDSG+N  + Y  + + +PG+F++    G +   
Sbjct: 570  DGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA 629

Query: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKR 1076
             +L   +  + +L +  +D G  P +A + LTV +  R
Sbjct: 630  RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADR 667



 Score =  168 bits (426), Expect = 3e-41
 Identities = 169/612 (27%), Positives = 272/612 (44%), Gaps = 60/612 (9%)

Query: 715  FRIDPHDGQICVSQDIDRERDPA-------TYDLLVEAKDGGGLSAQAF-VRVDLEDVND 766
            F ++P  G +  ++ IDRE   A       ++++LVE K       + F V V++ D+ND
Sbjct: 75   FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDK------MKLFPVEVEIIDIND 128

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
            N P F        +++ T PGT +      D D G+    +Y+L   + +  F++D   G
Sbjct: 129  NTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---SSNPHFSLDVQQG 185

Query: 827  I-------IYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
                    + L  PL   E     L+++A DGG         + I +      P  F + 
Sbjct: 186  ADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQA 245

Query: 880  KYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGD--LGGKFSIHPRLGTIRTRK 936
            +Y   V E+VP  + +  V A +P   ++  + Y   + D  +   F +    G I  ++
Sbjct: 246  QYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKE 305

Query: 937  PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            PLD E   +  + VQAQ G A   +  +V I V+DVNDN P    TS    + +  PPGT
Sbjct: 306  PLDFEEYKMYSMEVQAQDG-AGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGT 364

Query: 997  ALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLF-------LNGSLGAGEQREL 1049
             + L    D+DSG NG     I    P  F +++ +   +       L+  L +G     
Sbjct: 365  IIALISVHDQDSGDNGYTTCFIPGNLP--FKLEKLVDNYYRLVTERTLDRELISG----Y 418

Query: 1050 TLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
             +T+ A DQG    +    +++++ +  ++SP   F    Y   + E+      +   +A
Sbjct: 419  NITITAIDQGTPALSTETHISLLVTDINDNSP--VFHQDSYSAYIPENNPRGASIFSVRA 476

Query: 1109 HPLGPQRAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
            H L     A      +E ++     SA   I   TG +Y  R FDYE  +    +V A  
Sbjct: 477  HDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARD 536

Query: 1165 PEDGFL-QNVSTTVIVRVWDENDNSPTFLHDVL----FLKVEESPV---PQGVIGKITAI 1216
              D  L  NVS ++   + D+NDN+P  L+  L       VE +P+   P  ++ K+ A+
Sbjct: 537  SGDPPLSSNVSLSLF--LLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAV 594

Query: 1217 DMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR 1274
            D DSG+N  L Y LL  S+   F +  +TGE+    AL         + V V D G PP 
Sbjct: 595  DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654

Query: 1275 NATMAVYVSVTD 1286
            +AT+ + V+V D
Sbjct: 655  SATVTLTVAVAD 666



 Score =  140 bits (352), Expect = 1e-32
 Identities = 123/437 (28%), Positives = 203/437 (46%), Gaps = 42/437 (9%)

Query: 923  FSIHPRLGTIRTRKPLDHE-----TQPVVV---LTVQAQLGSAPACSSTEVNITVMDVND 974
            F+++PR G++ T + +D E     + P +V   + V+ ++   P      V + ++D+ND
Sbjct: 75   FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFP------VEVEIIDIND 128

Query: 975  NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV 1034
            N P F     E ++++ T PGT + L   +D D G N L  Y ++S     F++D   G 
Sbjct: 129  NTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPH--FSLDVQQGA 186

Query: 1035 -------LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEH 1086
                   + L   L   E+    L L A D G   ++  L + + V++  ++ P++T   
Sbjct: 187  DGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFT--Q 244

Query: 1087 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVD---SAMFGIRPYTGWI 1142
              Y + V E++   TQ+L   A    P   A+  + YS   +VD   + +F +  YTG I
Sbjct: 245  AQYHINVPENVPLGTQLLMVNA--TDPDEGANGEVTYSFH-NVDHRVAQIFRLDSYTGEI 301

Query: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 1202
              +   D+E  + Y+  V A   +DG        V+++V D NDN+P      +   V E
Sbjct: 302  SNKEPLDFEEYKMYSMEVQA---QDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPE 358

Query: 1203 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSD--GKFFKMNPNTGELINWVALDREHRGHH 1260
            +  P  +I  I+  D DSG NG    F+  +   K  K+  N   L+    LDRE    +
Sbjct: 359  NFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGY 418

Query: 1261 EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
             +T+   D+G+P  +    + + VTDINDN P F Q          + E  P    + +V
Sbjct: 419  NITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ----DSYSAYIPENNPRGASIFSV 474

Query: 1321 FAKDPDEGNNAEVTYSV 1337
             A D D   NA++TYS+
Sbjct: 475  RAHDLDSNENAQITYSL 491



 Score =  128 bits (322), Expect = 3e-29
 Identities = 121/429 (28%), Positives = 185/429 (43%), Gaps = 37/429 (8%)

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
            + PLD E + V  L + A  G  P  S T  + I V+D NDN PAF +    I + +  P
Sbjct: 197  QSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVP 256

Query: 994  PGTALYLARAEDRDSGRNGLIRYSIASPQPGV---FAIDRALGVLFLNGSLGAGEQRELT 1050
             GT L +  A D D G NG + YS  +    V   F +D   G +     L   E +  +
Sbjct: 257  LGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYS 316

Query: 1051 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
            + ++A+D G    A + VL  V++  +++P  T   +     V E+  P T +     H 
Sbjct: 317  MEVQAQD-GAGLMAKVKVLIKVLDVNDNAPEVTITSVT--TAVPENFPPGTIIALISVHD 373

Query: 1111 L-----GPQRAASP--LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
                  G      P  L + LE  VD+           +   R  D E    YN  + A 
Sbjct: 374  QDSGDNGYTTCFIPGNLPFKLEKLVDNYYR--------LVTERTLDRELISGYNITITA- 424

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
            I +     +  T + + V D NDNSP F  D     + E+      I  + A D+DS +N
Sbjct: 425  IDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNEN 484

Query: 1224 GQLLYFLLSD-------GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNA 1276
             Q+ Y L+ D         +  +N +TG L    + D E     ++ V+  D G PP ++
Sbjct: 485  AQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSS 544

Query: 1277 TMAVYVSVTDINDNRP--FFPQCLP---GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 1331
             +++ + + D NDN P   +P  LP      + +  L  +P   LVT V A D D G NA
Sbjct: 545  NVSLSLFLLDQNDNAPEILYP-ALPTDGSTGVELAPLSAEP-GYLVTKVVAVDRDSGQNA 602

Query: 1332 EVTYSVSSA 1340
             ++Y +  A
Sbjct: 603  WLSYRLLKA 611



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 67/215 (31%), Positives = 97/215 (45%), Gaps = 18/215 (8%)

Query: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRV---FAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
            +F + P +G +   R+ D E     +      F  + ED   +     V V + D NDN+
Sbjct: 74   LFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVED---KMKLFPVEVEIIDINDNT 130

Query: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTG---- 1244
            P F  + L  K+ E   P   +      D+D G N  L  + LS    F ++   G    
Sbjct: 131  PQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNS-LQSYQLSSNPHFSLDVQQGADGP 189

Query: 1245 ---ELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 1301
               E++    LDRE    H + +  +D G P R+ T+ +Y+ V D NDN P F Q     
Sbjct: 190  QHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQA---- 245

Query: 1302 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS 1336
            + H+ V E  P+   +  V A DPDEG N EVTYS
Sbjct: 246  QYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 48/175 (27%), Positives = 75/175 (42%), Gaps = 12/175 (6%)

Query: 1177 VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSD-- 1233
            + ++V D NDN P F      + V E+ VP G  +  + A D D G NG++ Y   +   
Sbjct: 228  IYIQVVDANDNPPAFTQAQYHINVPEN-VPLGTQLLMVNATDPDEGANGEVTYSFHNVDH 286

Query: 1234 --GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
               + F+++  TGE+ N   LD E    + M V   D       A + V + V D+NDN 
Sbjct: 287  RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNA 344

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLK 1346
            P     +    +   V E  P   ++  +   D D G+N   T  +    P  L+
Sbjct: 345  PE----VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLE 395


>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
           [Homo sapiens]
          Length = 936

 Score =  264 bits (675), Expect = 4e-70
 Identities = 218/715 (30%), Positives = 332/715 (46%), Gaps = 99/715 (13%)

Query: 69  LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
           ++ S+ E L   + VG+I   L  A ++             + L   F ++P +G + TA
Sbjct: 35  ISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQL---FSLNPRSGSLITA 91

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
            R+DRE     S         +V+       +EI V D+ND++P+F  ++L + ++E   
Sbjct: 92  GRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVA 151

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G  F LP A DPD G+ S Q Y L              F LR ++            ++
Sbjct: 152 AGMRFPLPEAIDPDVGVNSLQSYQL---------SPNKHFSLRVQS-----------RAN 191

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
            ++  +LVL   LDREE A H L + A DGG P R+G + V + V D NDN PVF   EY
Sbjct: 192 GVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEY 251

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E+   G ++  V ATDRD G NG V YS   R++P              F + + 
Sbjct: 252 RVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDT--------QLLKFQLNKY 301

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G +++   LD E   ++++ ++A DGGA   +AT +V I V DVNDN P + +  L   
Sbjct: 302 TGEIKISENLDYEETGFYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSL--- 356

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             + V+E +  G  VA ++V D D +                +G ++ S+       A L
Sbjct: 357 -FSPVTEDSPLGTVVALLNVHDLDSE---------------QNGQVTCSI------LAYL 394

Query: 482 P----GGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
           P          + L +   LDRE    Y + + ATD GSPPLSTE   +L+VAD+ND PP
Sbjct: 395 PFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPP 454

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            FSQ  Y   + E  A G  +  V+A D D    ++A + Y            SL    +
Sbjct: 455 TFSQVSYFTYIPENNARGASIFSVTALDPD--SKENAQIIY------------SLAEDTI 500

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
                    +I+S++G +  +R+ D E    ++++V A D G+PPLS+   +S+ V D N
Sbjct: 501 QGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQN 560

Query: 658 DNEPIFWRQVY---NATIAEHAP----VGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
           DN P           +T  E AP     G+   +V A D DSG   ++ Y L    L   
Sbjct: 561 DNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRL----LKAS 616

Query: 711 APQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLED 763
            P  F +  H G++  ++ +  +RD     L+V  +D G   LSA   + V + D
Sbjct: 617 EPGLFAVGEHTGEVRTARAL-LDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 670



 Score =  169 bits (427), Expect = 2e-41
 Identities = 150/564 (26%), Positives = 255/564 (45%), Gaps = 37/564 (6%)

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
            + V D+ND  P F  ++    ++E  A G       A D D   +          QLS P
Sbjct: 125  IEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNS-----LQSYQLS-P 178

Query: 587  CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
                SL+ +        P   ++          +LDRE +    L + A D G+P  S T
Sbjct: 179  NKHFSLRVQSRANGVKYPELVLE---------HSLDREEEAIHHLVLTASDGGDPLRSGT 229

Query: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
             LVS+TV D NDN P+F    Y  ++ E+ PVG   L VTA+D D G  G + YS     
Sbjct: 230  VLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRK-- 287

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
            L       F+++ + G+I +S+++D E +   Y++ ++A+DGG   A A V + +EDVND
Sbjct: 288  LPDTQLLKFQLNKYTGEIKISENLDYE-ETGFYEIEIQAEDGGAYLATAKVLITVEDVND 346

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL-FTIDSTT 825
            N P    ++  + +++++  GT +  +   D DS   G V   ++      L  +IDS  
Sbjct: 347  NSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYY 406

Query: 826  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
             ++ +   L   + ++ ++ V+A DGG       A   + +      P  F +  Y   +
Sbjct: 407  RLV-IHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYI 465

Query: 886  YEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGG-----KFSIHPRLGTIRTRKPLD 939
             E+    + I +V A +P    +  I Y ++   + G       SI+   G +   +  D
Sbjct: 466  PENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFD 525

Query: 940  HETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFL--------RTSDEIRISQ 990
            +E    + + V A   G  P  S+  +++ V+D NDN P  L         T  E+   +
Sbjct: 526  YEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVEL-APR 584

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQREL 1049
            +  PG  +    A DRDSG+N  + Y  + + +PG+FA+    G +    +L   +  + 
Sbjct: 585  SAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQ 644

Query: 1050 TLTLRAEDQGVHPQAALLVLTVVI 1073
            +L +  +D G  P +A + LTV +
Sbjct: 645  SLVVAVQDHGQPPLSATVTLTVAV 668



 Score =  165 bits (418), Expect = 2e-40
 Identities = 164/606 (27%), Positives = 263/606 (43%), Gaps = 44/606 (7%)

Query: 713  QAFRIDPHDGQICVSQDIDRE-------RDPATYDLLVEAKDGGGLSAQAF-VRVDLEDV 764
            Q F ++P  G +  +  IDRE       R   ++++LVE +       + F + +++ D+
Sbjct: 77   QLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDR------VKLFGIEIEVTDI 130

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
            NDN P F        I++    G       A D D G+    +Y+L P    SL      
Sbjct: 131  NDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRA 190

Query: 825  TGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPK 880
             G+ Y  L L H     E     L+++A DGG         V++ +F        F  P+
Sbjct: 191  NGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPE 250

Query: 881  YTFLVYEDVPEDSPIGTVKAR---EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKP 937
            Y   V E++P  + + TV A    E  N      +R        KF ++   G I+  + 
Sbjct: 251  YRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISEN 310

Query: 938  LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
            LD+E      + +QA+ G A   ++ +V ITV DVNDN P    TS    +++ +P GT 
Sbjct: 311  LDYEETGFYEIEIQAEDGGA-YLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTV 369

Query: 998  LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLR 1054
            + L    D DS +NG +  SI +  P  F +++++     L ++ +L   +     +T+ 
Sbjct: 370  VALLNVHDLDSEQNGQVTCSILAYLP--FKLEKSIDSYYRLVIHRALDREQVSSYNITVT 427

Query: 1055 AEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQ 1114
            A D G  P +      + +     +P  TF  + Y   + E+ +    +    A     +
Sbjct: 428  ATDGGSPPLSTEAHFMLQVADINDNPP-TFSQVSYFTYIPENNARGASIFSVTALDPDSK 486

Query: 1115 RAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 1170
              A  +    E ++     S+   I   TG +Y  R FDYE       +V A    D  L
Sbjct: 487  ENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPL 546

Query: 1171 Q-NVSTTVIVRVWDENDNSPTFLHDVL----FLKVEESP---VPQGVIGKITAIDMDSGK 1222
              NVS ++ V   D+NDN+P  L+  L       VE +P    P  ++ K+ A+D DSG+
Sbjct: 547  SSNVSLSLFVL--DQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ 604

Query: 1223 NGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 1280
            N  L Y LL  S+   F +  +TGE+    AL         + V V D G PP +AT+ +
Sbjct: 605  NAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL 664

Query: 1281 YVSVTD 1286
             V+V D
Sbjct: 665  TVAVAD 670



 Score =  141 bits (356), Expect = 4e-33
 Identities = 128/430 (29%), Positives = 189/430 (43%), Gaps = 26/430 (6%)

Query: 923  FSIHPRLGTIRTRKPLDHET----QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978
            FS++PR G++ T   +D E         V++    +         E+ +T  D+NDN P 
Sbjct: 79   FSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVT--DINDNAPK 136

Query: 979  FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAI-DRALGV--- 1034
            F   + +++I++    G    L  A D D G N L  Y ++  +     +  RA GV   
Sbjct: 137  FQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYP 196

Query: 1035 -LFLNGSLGAGEQRELTLTLRAEDQGVHPQA-ALLVLTVVIEKREHSPSWTFEHLVYQVE 1092
             L L  SL   E+    L L A D G   ++  +LV   V +  +++P +T     Y+V 
Sbjct: 197  ELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPE--YRVS 254

Query: 1093 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE--PSVDSAMFGIRPYTGWIYLRRQFDY 1150
            V E+L   TQ+L   A     + A   + YS    P      F +  YTG I +    DY
Sbjct: 255  VPENLPVGTQLLTVTATD-RDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDY 313

Query: 1151 ESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI 1210
            E T  Y   + A   EDG     +  V++ V D NDNSP      LF  V E      V+
Sbjct: 314  EETGFYEIEIQA---EDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVV 370

Query: 1211 GKITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
              +   D+DS +NGQ+   +L+    K  K   +   L+   ALDRE    + +TV  TD
Sbjct: 371  ALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATD 430

Query: 1269 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 1328
             GSPP +      + V DINDN P F Q          + E       + +V A DPD  
Sbjct: 431  GGSPPLSTEAHFMLQVADINDNPPTFSQV----SYFTYIPENNARGASIFSVTALDPDSK 486

Query: 1329 NNAEVTYSVS 1338
             NA++ YS++
Sbjct: 487  ENAQIIYSLA 496



 Score =  140 bits (354), Expect = 6e-33
 Identities = 127/430 (29%), Positives = 192/430 (44%), Gaps = 45/430 (10%)

Query: 938  LDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            LD E + +  L + A  G  P  S T  V++TV D NDN P F      + + +  P GT
Sbjct: 204  LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGT 263

Query: 997  ALYLARAEDRDSGRNGLIRYS---IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             L    A DRD G NG + YS   +   Q   F +++  G + ++ +L   E     + +
Sbjct: 264  QLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEI 323

Query: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
            +AED G +   A +++TV  +  ++SP  T   L   V     L  +  +L    H L  
Sbjct: 324  QAEDGGAYLATAKVLITVE-DVNDNSPELTITSLFSPVTEDSPLGTVVALL--NVHDLDS 380

Query: 1114 QR-------AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
            ++         + L + LE S+DS           + + R  D E   +YN  V A    
Sbjct: 381  EQNGQVTCSILAYLPFKLEKSIDSYY--------RLVIHRALDREQVSSYNITVTA---T 429

Query: 1167 DGFLQNVSTTV--IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
            DG    +ST    +++V D NDN PTF     F  + E+      I  +TA+D DS +N 
Sbjct: 430  DGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENA 489

Query: 1225 QLLYFLLSD-------GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNAT 1277
            Q++Y L  D         +  +N +TG L    + D E     +M V  +D G PP ++ 
Sbjct: 490  QIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSN 549

Query: 1278 MAVYVSVTDINDNRP--FFPQCLP-----GKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
            +++ + V D NDN P   +P  LP     G EL  +  E      LVT V A D D G N
Sbjct: 550  VSLSLFVLDQNDNAPEILYP-ALPTDGSTGVELAPRSAE---PGYLVTKVVAVDRDSGQN 605

Query: 1331 AEVTYSVSSA 1340
            A ++Y +  A
Sbjct: 606  AWLSYRLLKA 615



 Score =  138 bits (348), Expect = 3e-32
 Identities = 144/564 (25%), Positives = 239/564 (42%), Gaps = 31/564 (5%)

Query: 606  FAIDSESGAISTIRTLDREVQEAVELK-VVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
            F+++  SG++ T   +DRE   A   + VV+ ++          + I V D+NDN P F 
Sbjct: 79   FSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQ 138

Query: 665  RQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI 724
             +  +  I E+   G  F    A D D G+     Y L          Q+        ++
Sbjct: 139  AENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPEL 198

Query: 725  CVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
             +   +DRE + A + L++ A DGG    S    V V + D NDN PVF    Y  S+ +
Sbjct: 199  VLEHSLDREEE-AIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPE 257

Query: 783  ETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
                GT+++ V ATD+D G  G V Y    +P      F ++  TG I ++  L + E+ 
Sbjct: 258  NLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETG 317

Query: 841  TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL-VYEDVPEDSPIGTVK 899
               + + A+DGG   A     +T+              P+ T   ++  V EDSP+GTV 
Sbjct: 318  FYEIEIQAEDGGAYLATAKVLITVE-------DVNDNSPELTITSLFSPVTEDSPLGTVV 370

Query: 900  AREPLN--SSEPIFYRISSGDLGGKFSIHPRLGT---IRTRKPLDHETQPVVVLTVQAQL 954
            A   ++   SE       S      F +   + +   +   + LD E      +TV A  
Sbjct: 371  ALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATD 430

Query: 955  GSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
            G +P  S+     + V D+NDN P F + S    I +    G +++   A D DS  N  
Sbjct: 431  GGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQ 490

Query: 1014 IRYSIAS------PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 1067
            I YS+A       P     +I+   GVL+   S    +  EL + + A D G  P ++ +
Sbjct: 491  IIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNV 550

Query: 1068 VLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQ---MLQTQAHPLGPQRAASP-LRY 1122
             L++ V+++ +++P   +  L         L+P +     L T+   +      +  L Y
Sbjct: 551  SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSY 610

Query: 1123 SLEPSVDSAMFGIRPYTGWIYLRR 1146
             L  + +  +F +  +TG +   R
Sbjct: 611  RLLKASEPGLFAVGEHTGEVRTAR 634



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 72/196 (36%), Positives = 92/196 (46%), Gaps = 22/196 (11%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 1238
            + V D NDN+P F  + L +K+ E+           AID D G N  L  + LS  K F 
Sbjct: 125  IEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNS-LQSYQLSPNKHFS 183

Query: 1239 MNPNTG-------ELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
            +   +        EL+   +LDRE    H + +  +D G P R+ T+ V V+V D NDN 
Sbjct: 184  LRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNA 243

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAF 1351
            P F   LP  E  V V E  PV   + TV A D DEG N EVTYS    R +P       
Sbjct: 244  PVF--TLP--EYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF---RKLP------- 289

Query: 1352 GKQSCKKQTNKQTNKI 1367
              Q  K Q NK T +I
Sbjct: 290  DTQLLKFQLNKYTGEI 305


>gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precursor
           [Homo sapiens]
          Length = 850

 Score =  264 bits (675), Expect = 4e-70
 Identities = 218/715 (30%), Positives = 332/715 (46%), Gaps = 99/715 (13%)

Query: 69  LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
           ++ S+ E L   + VG+I   L  A ++             + L   F ++P +G + TA
Sbjct: 35  ISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQL---FSLNPRSGSLITA 91

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
            R+DRE     S         +V+       +EI V D+ND++P+F  ++L + ++E   
Sbjct: 92  GRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVA 151

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G  F LP A DPD G+ S Q Y L              F LR ++            ++
Sbjct: 152 AGMRFPLPEAIDPDVGVNSLQSYQL---------SPNKHFSLRVQS-----------RAN 191

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
            ++  +LVL   LDREE A H L + A DGG P R+G + V + V D NDN PVF   EY
Sbjct: 192 GVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEY 251

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E+   G ++  V ATDRD G NG V YS   R++P              F + + 
Sbjct: 252 RVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDT--------QLLKFQLNKY 301

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G +++   LD E   ++++ ++A DGGA   +AT +V I V DVNDN P + +  L   
Sbjct: 302 TGEIKISENLDYEETGFYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSL--- 356

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             + V+E +  G  VA ++V D D +                +G ++ S+       A L
Sbjct: 357 -FSPVTEDSPLGTVVALLNVHDLDSE---------------QNGQVTCSI------LAYL 394

Query: 482 P----GGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
           P          + L +   LDRE    Y + + ATD GSPPLSTE   +L+VAD+ND PP
Sbjct: 395 PFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPP 454

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            FSQ  Y   + E  A G  +  V+A D D    ++A + Y            SL    +
Sbjct: 455 TFSQVSYFTYIPENNARGASIFSVTALDPD--SKENAQIIY------------SLAEDTI 500

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
                    +I+S++G +  +R+ D E    ++++V A D G+PPLS+   +S+ V D N
Sbjct: 501 QGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQN 560

Query: 658 DNEPIFWRQVY---NATIAEHAP----VGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
           DN P           +T  E AP     G+   +V A D DSG   ++ Y L    L   
Sbjct: 561 DNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRL----LKAS 616

Query: 711 APQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLED 763
            P  F +  H G++  ++ +  +RD     L+V  +D G   LSA   + V + D
Sbjct: 617 EPGLFAVGEHTGEVRTARAL-LDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 670



 Score =  169 bits (427), Expect = 2e-41
 Identities = 150/564 (26%), Positives = 255/564 (45%), Gaps = 37/564 (6%)

Query: 527  LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
            + V D+ND  P F  ++    ++E  A G       A D D   +          QLS P
Sbjct: 125  IEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNS-----LQSYQLS-P 178

Query: 587  CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
                SL+ +        P   ++          +LDRE +    L + A D G+P  S T
Sbjct: 179  NKHFSLRVQSRANGVKYPELVLE---------HSLDREEEAIHHLVLTASDGGDPLRSGT 229

Query: 647  CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
             LVS+TV D NDN P+F    Y  ++ E+ PVG   L VTA+D D G  G + YS     
Sbjct: 230  VLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRK-- 287

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
            L       F+++ + G+I +S+++D E +   Y++ ++A+DGG   A A V + +EDVND
Sbjct: 288  LPDTQLLKFQLNKYTGEIKISENLDYE-ETGFYEIEIQAEDGGAYLATAKVLITVEDVND 346

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL-FTIDSTT 825
            N P    ++  + +++++  GT +  +   D DS   G V   ++      L  +IDS  
Sbjct: 347  NSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYY 406

Query: 826  GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
             ++ +   L   + ++ ++ V+A DGG       A   + +      P  F +  Y   +
Sbjct: 407  RLV-IHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYI 465

Query: 886  YEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGG-----KFSIHPRLGTIRTRKPLD 939
             E+    + I +V A +P    +  I Y ++   + G       SI+   G +   +  D
Sbjct: 466  PENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFD 525

Query: 940  HETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFL--------RTSDEIRISQ 990
            +E    + + V A   G  P  S+  +++ V+D NDN P  L         T  E+   +
Sbjct: 526  YEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVEL-APR 584

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYS-IASPQPGVFAIDRALGVLFLNGSLGAGEQREL 1049
            +  PG  +    A DRDSG+N  + Y  + + +PG+FA+    G +    +L   +  + 
Sbjct: 585  SAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQ 644

Query: 1050 TLTLRAEDQGVHPQAALLVLTVVI 1073
            +L +  +D G  P +A + LTV +
Sbjct: 645  SLVVAVQDHGQPPLSATVTLTVAV 668



 Score =  165 bits (418), Expect = 2e-40
 Identities = 164/606 (27%), Positives = 263/606 (43%), Gaps = 44/606 (7%)

Query: 713  QAFRIDPHDGQICVSQDIDRE-------RDPATYDLLVEAKDGGGLSAQAF-VRVDLEDV 764
            Q F ++P  G +  +  IDRE       R   ++++LVE +       + F + +++ D+
Sbjct: 77   QLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDR------VKLFGIEIEVTDI 130

Query: 765  NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
            NDN P F        I++    G       A D D G+    +Y+L P    SL      
Sbjct: 131  NDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRA 190

Query: 825  TGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPK 880
             G+ Y  L L H     E     L+++A DGG         V++ +F        F  P+
Sbjct: 191  NGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPE 250

Query: 881  YTFLVYEDVPEDSPIGTVKAR---EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKP 937
            Y   V E++P  + + TV A    E  N      +R        KF ++   G I+  + 
Sbjct: 251  YRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISEN 310

Query: 938  LDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
            LD+E      + +QA+ G A   ++ +V ITV DVNDN P    TS    +++ +P GT 
Sbjct: 311  LDYEETGFYEIEIQAEDGGA-YLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTV 369

Query: 998  LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGV---LFLNGSLGAGEQRELTLTLR 1054
            + L    D DS +NG +  SI +  P  F +++++     L ++ +L   +     +T+ 
Sbjct: 370  VALLNVHDLDSEQNGQVTCSILAYLP--FKLEKSIDSYYRLVIHRALDREQVSSYNITVT 427

Query: 1055 AEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQ 1114
            A D G  P +      + +     +P  TF  + Y   + E+ +    +    A     +
Sbjct: 428  ATDGGSPPLSTEAHFMLQVADINDNPP-TFSQVSYFTYIPENNARGASIFSVTALDPDSK 486

Query: 1115 RAASPLRYSLEPSVD----SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 1170
              A  +    E ++     S+   I   TG +Y  R FDYE       +V A    D  L
Sbjct: 487  ENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPL 546

Query: 1171 Q-NVSTTVIVRVWDENDNSPTFLHDVL----FLKVEESP---VPQGVIGKITAIDMDSGK 1222
              NVS ++ V   D+NDN+P  L+  L       VE +P    P  ++ K+ A+D DSG+
Sbjct: 547  SSNVSLSLFVL--DQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ 604

Query: 1223 NGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAV 1280
            N  L Y LL  S+   F +  +TGE+    AL         + V V D G PP +AT+ +
Sbjct: 605  NAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL 664

Query: 1281 YVSVTD 1286
             V+V D
Sbjct: 665  TVAVAD 670



 Score =  141 bits (356), Expect = 4e-33
 Identities = 128/430 (29%), Positives = 189/430 (43%), Gaps = 26/430 (6%)

Query: 923  FSIHPRLGTIRTRKPLDHET----QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978
            FS++PR G++ T   +D E         V++    +         E+ +T  D+NDN P 
Sbjct: 79   FSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVT--DINDNAPK 136

Query: 979  FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAI-DRALGV--- 1034
            F   + +++I++    G    L  A D D G N L  Y ++  +     +  RA GV   
Sbjct: 137  FQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYP 196

Query: 1035 -LFLNGSLGAGEQRELTLTLRAEDQGVHPQA-ALLVLTVVIEKREHSPSWTFEHLVYQVE 1092
             L L  SL   E+    L L A D G   ++  +LV   V +  +++P +T     Y+V 
Sbjct: 197  ELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPE--YRVS 254

Query: 1093 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLE--PSVDSAMFGIRPYTGWIYLRRQFDY 1150
            V E+L   TQ+L   A     + A   + YS    P      F +  YTG I +    DY
Sbjct: 255  VPENLPVGTQLLTVTATD-RDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDY 313

Query: 1151 ESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI 1210
            E T  Y   + A   EDG     +  V++ V D NDNSP      LF  V E      V+
Sbjct: 314  EETGFYEIEIQA---EDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVV 370

Query: 1211 GKITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
              +   D+DS +NGQ+   +L+    K  K   +   L+   ALDRE    + +TV  TD
Sbjct: 371  ALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATD 430

Query: 1269 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEG 1328
             GSPP +      + V DINDN P F Q          + E       + +V A DPD  
Sbjct: 431  GGSPPLSTEAHFMLQVADINDNPPTFSQV----SYFTYIPENNARGASIFSVTALDPDSK 486

Query: 1329 NNAEVTYSVS 1338
             NA++ YS++
Sbjct: 487  ENAQIIYSLA 496



 Score =  140 bits (354), Expect = 6e-33
 Identities = 127/430 (29%), Positives = 192/430 (44%), Gaps = 45/430 (10%)

Query: 938  LDHETQPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGT 996
            LD E + +  L + A  G  P  S T  V++TV D NDN P F      + + +  P GT
Sbjct: 204  LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGT 263

Query: 997  ALYLARAEDRDSGRNGLIRYS---IASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
             L    A DRD G NG + YS   +   Q   F +++  G + ++ +L   E     + +
Sbjct: 264  QLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEI 323

Query: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
            +AED G +   A +++TV  +  ++SP  T   L   V     L  +  +L    H L  
Sbjct: 324  QAEDGGAYLATAKVLITVE-DVNDNSPELTITSLFSPVTEDSPLGTVVALL--NVHDLDS 380

Query: 1114 QR-------AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
            ++         + L + LE S+DS           + + R  D E   +YN  V A    
Sbjct: 381  EQNGQVTCSILAYLPFKLEKSIDSYY--------RLVIHRALDREQVSSYNITVTA---T 429

Query: 1167 DGFLQNVSTTV--IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
            DG    +ST    +++V D NDN PTF     F  + E+      I  +TA+D DS +N 
Sbjct: 430  DGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENA 489

Query: 1225 QLLYFLLSD-------GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNAT 1277
            Q++Y L  D         +  +N +TG L    + D E     +M V  +D G PP ++ 
Sbjct: 490  QIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSN 549

Query: 1278 MAVYVSVTDINDNRP--FFPQCLP-----GKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
            +++ + V D NDN P   +P  LP     G EL  +  E      LVT V A D D G N
Sbjct: 550  VSLSLFVLDQNDNAPEILYP-ALPTDGSTGVELAPRSAE---PGYLVTKVVAVDRDSGQN 605

Query: 1331 AEVTYSVSSA 1340
            A ++Y +  A
Sbjct: 606  AWLSYRLLKA 615



 Score =  138 bits (348), Expect = 3e-32
 Identities = 144/564 (25%), Positives = 239/564 (42%), Gaps = 31/564 (5%)

Query: 606  FAIDSESGAISTIRTLDREVQEAVELK-VVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
            F+++  SG++ T   +DRE   A   + VV+ ++          + I V D+NDN P F 
Sbjct: 79   FSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQ 138

Query: 665  RQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI 724
             +  +  I E+   G  F    A D D G+     Y L          Q+        ++
Sbjct: 139  AENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPEL 198

Query: 725  CVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
             +   +DRE + A + L++ A DGG    S    V V + D NDN PVF    Y  S+ +
Sbjct: 199  VLEHSLDREEE-AIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPE 257

Query: 783  ETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
                GT+++ V ATD+D G  G V Y    +P      F ++  TG I ++  L + E+ 
Sbjct: 258  NLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETG 317

Query: 841  TLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL-VYEDVPEDSPIGTVK 899
               + + A+DGG   A     +T+              P+ T   ++  V EDSP+GTV 
Sbjct: 318  FYEIEIQAEDGGAYLATAKVLITVE-------DVNDNSPELTITSLFSPVTEDSPLGTVV 370

Query: 900  AREPLN--SSEPIFYRISSGDLGGKFSIHPRLGT---IRTRKPLDHETQPVVVLTVQAQL 954
            A   ++   SE       S      F +   + +   +   + LD E      +TV A  
Sbjct: 371  ALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATD 430

Query: 955  GSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
            G +P  S+     + V D+NDN P F + S    I +    G +++   A D DS  N  
Sbjct: 431  GGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQ 490

Query: 1014 IRYSIAS------PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALL 1067
            I YS+A       P     +I+   GVL+   S    +  EL + + A D G  P ++ +
Sbjct: 491  IIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNV 550

Query: 1068 VLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQ---MLQTQAHPLGPQRAASP-LRY 1122
             L++ V+++ +++P   +  L         L+P +     L T+   +      +  L Y
Sbjct: 551  SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSY 610

Query: 1123 SLEPSVDSAMFGIRPYTGWIYLRR 1146
             L  + +  +F +  +TG +   R
Sbjct: 611  RLLKASEPGLFAVGEHTGEVRTAR 634



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 72/196 (36%), Positives = 92/196 (46%), Gaps = 22/196 (11%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 1238
            + V D NDN+P F  + L +K+ E+           AID D G N  L  + LS  K F 
Sbjct: 125  IEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNS-LQSYQLSPNKHFS 183

Query: 1239 MNPNTG-------ELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
            +   +        EL+   +LDRE    H + +  +D G P R+ T+ V V+V D NDN 
Sbjct: 184  LRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNA 243

Query: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKTAF 1351
            P F   LP  E  V V E  PV   + TV A D DEG N EVTYS    R +P       
Sbjct: 244  PVF--TLP--EYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF---RKLP------- 289

Query: 1352 GKQSCKKQTNKQTNKI 1367
              Q  K Q NK T +I
Sbjct: 290  DTQLLKFQLNKYTGEI 305


>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
          Length = 1072

 Score =  262 bits (670), Expect = 1e-69
 Identities = 265/920 (28%), Positives = 385/920 (41%), Gaps = 151/920 (16%)

Query: 62  SSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPD 121
           ++ QL    L+ +EG P D  +G++ + L       G   F  E   +   +D+      
Sbjct: 29  AAKQLLRYRLA-EEG-PADVRIGNVASDLGIVTGS-GEVTFSLESGSEYLKIDNL----- 80

Query: 122 TGIIRTA-RRLDRERRDHYSFV----------AATLLGA------VVQVEIRVNDVNDHS 164
           TG + T+ RR+DRE+      +            +++G       + + ++ V D+ND++
Sbjct: 81  TGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNT 140

Query: 165 PRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLR 224
           P FP   L L V E  P GT + LP A D D G    + Y L+Q      +P G      
Sbjct: 141 PTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQ------EPGGGGSGGE 194

Query: 225 YRTPGPLPSPLLPG----------SSSPLEPLD--------------------------- 247
            R  G   S   PG          S      LD                           
Sbjct: 195 SRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDG 254

Query: 248 -----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
                L++   LDRE+  ++ L +   DGG P R+    + + + D NDN P FE+  Y 
Sbjct: 255 EKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYE 314

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
           A + E++ PG  + ++RA D D+G NG + Y            G           ++E S
Sbjct: 315 ADLAENSAPGTPILQLRAADLDVGVNGQIEYVF----------GAATESVRRLLRLDETS 364

Query: 363 GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL---- 418
           G + V   +DRE     +  V ARD G  P+     V + + D NDN P+I +  +    
Sbjct: 365 GWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIP 424

Query: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV----GLGDGSISLS-LEG 473
            + GVA V+E       +A V VSD D          GE GV     +GD    L     
Sbjct: 425 LKDGVANVAEDVLVDTPIALVQVSDRD---------QGENGVVTCTVVGDVPFQLKPASD 475

Query: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
            EGD           +FL    PLD E+   + +++VA D+GSP LS+  +L+++V D N
Sbjct: 476 TEGD------QNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTN 529

Query: 534 DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
           D PP+F Q   +    E   PG  V  V A+DAD     +A + Y            SL 
Sbjct: 530 DNPPMFGQSVVEVYFPENNIPGERVATVLATDAD--SGKNAEIAY------------SLD 575

Query: 594 SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
           S ++        FAID +SG I     LDRE  +  E KV A+D G P L  +  V + V
Sbjct: 576 SSVMGI------FAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQV 629

Query: 654 DDVNDNEPIFWRQVYNATIAE----HAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
            D NDN+P F + V+   + E    ++PVG     VT  DAD G     E SLY      
Sbjct: 630 ADKNDNDPKFMQDVFTFYVKENLQPNSPVG----MVTVMDADKGRNA--EMSLY----IE 679

Query: 710 EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDN 767
           E    F I+   G I  +   DRE    TY   V+A DGG    SA A V + + D NDN
Sbjct: 680 ENNNIFSIENDTGTIYSTMSFDREHQ-TTYTFRVKAVDGGDPPRSATATVSLFVMDENDN 738

Query: 768 HPVFN--PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTT 825
            P      +   T +   +   T +  VLATD D GI   + Y ++ GN   LF ID T+
Sbjct: 739 APTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTS 798

Query: 826 GIIYLTLPLSHLESTTLSLMVSAQDGG----GLTAVINADVTIHIFQTTLAPAEFERPKY 881
           G++ L   L+        L+V   D G      T +++  V   +   T   ++  R  +
Sbjct: 799 GVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLH 858

Query: 882 TFLVYEDVPEDSPIGTVKAR 901
             L  +D+  D      K R
Sbjct: 859 IPLT-QDIAGDPSYEISKQR 877



 Score =  201 bits (510), Expect = 5e-51
 Identities = 173/596 (29%), Positives = 267/596 (44%), Gaps = 37/596 (6%)

Query: 723  QICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
            Q+ V   +DRE+  + Y+L +  +DGG    S+QA +RV + DVNDN P F  S Y   +
Sbjct: 259  QLIVKGALDREQRDS-YELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317

Query: 781  SDETQPGTEIINVLATDQDSGIYGTVAYEL--IPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
            ++ + PGT I+ + A D D G+ G + Y       +V  L  +D T+G + +   +   E
Sbjct: 318  AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377

Query: 839  STTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL--------VYEDVP 890
               L   V A+D G       A V ++I          E  K   +        V EDV 
Sbjct: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437

Query: 891  EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGT----------IRTRKPLDH 940
             D+PI  V+  +       +      GD+   F + P   T          + T  PLD+
Sbjct: 438  VDTPIALVQVSDRDQGENGVVTCTVVGDV--PFQLKPASDTEGDQNKKKYFLHTSTPLDY 495

Query: 941  E-TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY 999
            E T+   V+ V    GS    S+  + + V D NDN P F ++  E+   +   PG  + 
Sbjct: 496  EATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVA 555

Query: 1000 LARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG 1059
               A D DSG+N  I YS+ S   G+FAID   G + +N  L   +       + A+D+G
Sbjct: 556  TVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615

Query: 1060 VHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118
            +   Q +  V+  V +K ++ P   F   V+   V E+L P + +           R A 
Sbjct: 616  IPVLQGSTTVIVQVADKNDNDPK--FMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAE 673

Query: 1119 PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI 1178
               Y  E   ++ +F I   TG IY    FD E   TY FRV A    D   ++ + TV 
Sbjct: 674  MSLYIEE---NNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP-PRSATATVS 729

Query: 1179 VRVWDENDNSPTFL--HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF 1236
            + V DENDN+PT     ++ +  +  S   + V+  + A D D G N  L Y ++    F
Sbjct: 730  LFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPF 789

Query: 1237 --FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
              F+++P +G +     L ++H G H + V V D G P ++ T  V+V V +   N
Sbjct: 790  KLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSN 845



 Score =  166 bits (419), Expect = 2e-40
 Identities = 198/781 (25%), Positives = 318/781 (40%), Gaps = 120/781 (15%)

Query: 665  RQVYNATIAEHAPVGHCFLQVTASDADSGLY---GFIEYSLYDGFLSYEAPQAFRIDPHD 721
            +Q+    +AE  P     +++    +D G+    G + +SL  G       +  +ID   
Sbjct: 31   KQLLRYRLAEEGPAD---VRIGNVASDLGIVTGSGEVTFSLESG------SEYLKIDNLT 81

Query: 722  GQICVSQD-IDRERDPATYDLLVEAKDGGGLS------AQAFV-----RVDLEDVNDNHP 769
            G++  S+  IDRE+ P    +  E +            +Q++V     +V + D+NDN P
Sbjct: 82   GELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTP 141

Query: 770  VFNPSTYVTSISDETQP-GTEIINVLATDQDSGIYGTVAYELI----------------- 811
             F PS  +T   +E +P GT  +   ATD+D G  G   YEL+                 
Sbjct: 142  TF-PSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGA 200

Query: 812  ------------------------------------PGNVSSLFTI---DSTTG------ 826
                                                PG  SS+F +   D+  G      
Sbjct: 201  ADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQL 260

Query: 827  IIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 886
            I+   L     +S  L+L V  +DGG       A + + I         FE+  Y   + 
Sbjct: 261  IVKGALDREQRDSYELTLRV--RDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLA 318

Query: 887  EDVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 943
            E+    +PI  ++A +    +N      +  ++  +     +    G +     +D E  
Sbjct: 319  ENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEV 378

Query: 944  PVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAF-LRTSDEI-------RISQTTPP 994
              +  TV A+  G  P      V + + D NDN P+  +R    I        +++    
Sbjct: 379  NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV 438

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAI--------DRALGVLFLNGS--LGAG 1044
             T + L +  DRD G NG++  ++    P  F +        D+     FL+ S  L   
Sbjct: 439  DTPIALVQVSDRDQGENGVVTCTVVGDVP--FQLKPASDTEGDQNKKKYFLHTSTPLDYE 496

Query: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQML 1104
              RE  + + A D G    ++   L V +     +P   F   V +V   E+  P  ++ 
Sbjct: 497  ATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPM-FGQSVVEVYFPENNIPGERVA 555

Query: 1105 QTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
               A      + A  + YSL+ SV   +F I P +G I +    D E T  Y F+V A  
Sbjct: 556  TVLATDADSGKNAE-IAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKD 613

Query: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
                 LQ  STTVIV+V D+NDN P F+ DV    V+E+  P   +G +T +D D G+N 
Sbjct: 614  KGIPVLQG-STTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNA 672

Query: 1225 QLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSV 1284
            ++  ++  +   F +  +TG + + ++ DREH+  +   V   D G PPR+AT  V + V
Sbjct: 673  EMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFV 732

Query: 1285 TDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMP 1344
             D NDN P     LP    +  +     V  +V TV A D D+G NA++ YS+    P  
Sbjct: 733  MDENDNAP--TVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK 790

Query: 1345 L 1345
            L
Sbjct: 791  L 791



 Score =  146 bits (369), Expect = 1e-34
 Identities = 145/614 (23%), Positives = 257/614 (41%), Gaps = 35/614 (5%)

Query: 621  LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGH 680
            LDRE +++ EL +  +D G+PP S+  ++ + + DVNDN P F + VY A +AE++  G 
Sbjct: 266  LDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGT 325

Query: 681  CFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER-DPATY 739
              LQ+ A+D D G+ G IEY    G  +    +  R+D   G + V   IDRE  +   +
Sbjct: 326  PILQLRAADLDVGVNGQIEYVF--GAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRF 383

Query: 740  DLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTY--------VTSISDETQPGTEII 791
             ++   +     + +A V ++++D NDN P               V +++++    T I 
Sbjct: 384  TVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIA 443

Query: 792  NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG-------IIYLTLPLSHLESTTLSL 844
             V  +D+D G  G V   ++      L     T G        ++ + PL +  +   ++
Sbjct: 444  LVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNV 503

Query: 845  MVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-P 903
            ++ A D G  +   N  + + +  T   P  F +        E+      + TV A +  
Sbjct: 504  VIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDAD 563

Query: 904  LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC-SS 962
               +  I Y + S  + G F+I P  G I     LD E        V A+    P    S
Sbjct: 564  SGKNAEIAYSLDSSVM-GIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGS 622

Query: 963  TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ 1022
            T V + V D NDN P F++      + +   P + + +    D D GRN  +   I    
Sbjct: 623  TTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYI-EEN 681

Query: 1023 PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPS 1081
              +F+I+   G ++   S     Q   T  ++A D G  P++A   +++ V+++ +++P+
Sbjct: 682  NNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT 741

Query: 1082 WTFEHLVYQVEVSESLSPMTQMLQTQAHPL----GPQRAASPLRYSLEPSVDSAMFGIRP 1137
             T         +S +L P +  ++T    +          + L YS+       +F I P
Sbjct: 742  VTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDP 796

Query: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF 1197
             +G + L  +    + + Y          D    + STT +V V+     S     D   
Sbjct: 797  TSGVVSLVGKL---TQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQI 853

Query: 1198 LKVEESPVPQGVIG 1211
             +    P+ Q + G
Sbjct: 854  ARSLHIPLTQDIAG 867



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 58/189 (30%), Positives = 83/189 (43%), Gaps = 9/189 (4%)

Query: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 1238
            V + D NDNSP F   V    + E+  P   I ++ A D+D G NGQ+ Y   +  +  +
Sbjct: 296  VLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVR 355

Query: 1239 MNPNTGELINWVA----LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294
                  E   W++    +DRE       TV+  DRG PP+     V +++ D NDN P  
Sbjct: 356  RLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSI 415

Query: 1295 P----QCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLK-GKT 1349
                   +P K+    V E   V+  +  V   D D+G N  VT +V    P  LK    
Sbjct: 416  EIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASD 475

Query: 1350 AFGKQSCKK 1358
              G Q+ KK
Sbjct: 476  TEGDQNKKK 484


>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  261 bits (668), Expect = 2e-69
 Identities = 219/711 (30%), Positives = 323/711 (45%), Gaps = 105/711 (14%)

Query: 73  VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
           + E +P  ++VG++   L  + Q+  +       S + P    F V  ++G +  + RLD
Sbjct: 37  IPEEMPKGSVVGNLATDLGFSVQELPTRKL--RVSSEKPY---FTVSAESGELLVSSRLD 91

Query: 133 RERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
           RE         A    AV +       V + + D+NDH+P+F  +S +L +SE + PGT 
Sbjct: 92  REEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR 151

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
           F L VA D D GL S Q Y L            P F L  +           GS  P   
Sbjct: 152 FILEVAEDADIGLNSLQKYKL---------SLNPSFSLIIKEKQD-------GSKYP--- 192

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
            +L L + LDRE+ + HRL + A DGG P  +G   + ++V D NDNPPVF +D YR ++
Sbjct: 193 -ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSL 251

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           RE+  PG  V +V ATD+D G N  + YS  R  Q+               F++   SG 
Sbjct: 252 RENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI---------------FSLNSKSGE 296

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           +   + LD E    + +VVE RDGG    VA   V I + D NDN P +    L E    
Sbjct: 297 ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLE---- 350

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
            + E A PG  +A + + D D         +GE      +G ++  L+ GE  F ++   
Sbjct: 351 MILENAVPGTLIALIKIHDQD---------SGE------NGEVNCQLQ-GEVPFKII-SS 393

Query: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544
               + L  +G LDRE    Y + + ATD G PPLS+  +++L + D+ND  P+F Q  Y
Sbjct: 394 SKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASY 453

Query: 545 KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604
             SV E   PG  +  V ASD D             + L+   +   + S +   A    
Sbjct: 454 LVSVPENNPPGASIAQVCASDLD-------------LGLNGQVSYSIMASDLEPLA-LAS 499

Query: 605 SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
             ++ ++SG +   R  D E     EL + A+D G P LSA   + + V D NDN P   
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP--- 556

Query: 665 RQVYNA----------TIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
           R +Y A           +   A  G+   +V A DADSG   ++ Y +    L    P  
Sbjct: 557 RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV----LQASEPGL 612

Query: 715 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLED 763
           F +    G++  ++ +  +RD A   LLV  +DGG   LSA A + +   D
Sbjct: 613 FSLGLRTGEVRTARALG-DRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662



 Score =  189 bits (479), Expect = 2e-47
 Identities = 174/646 (26%), Positives = 278/646 (43%), Gaps = 96/646 (14%)

Query: 247 DLVLLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
           +L++  RLDREE    +    L+ EA             V + + D ND+ P F Q+ + 
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAV---AENPLNFYHVNVEIEDINDHTPKFTQNSFE 139

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             + E AQPG       A D D+G N   +Y +             +L  +    ++E  
Sbjct: 140 LQISESAQPGTRFILEVAEDADIGLNSLQKYKL-------------SLNPSFSLIIKEKQ 186

Query: 363 G-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
                  + + + LDRE Q++H+LV+ A DGG  P   T  + I V D NDN P  +   
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN--- 243

Query: 418 LTEGGVARVS--EGARPGDYVARVSVSDADGDWEKEDE----ATGELGVGLGDGSISLSL 471
                V RVS  E   PG  V +VS +D D     E       TG++         SL+ 
Sbjct: 244 ---RDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI--------FSLNS 292

Query: 472 EGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
           + GE               +  +  LD E    Y +++   D G   L  + T+ + + D
Sbjct: 293 KSGE---------------ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQD 335

Query: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-G 590
            ND  P  +       + E A PGT++  +   D D   +               C L G
Sbjct: 336 ENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV-----------NCQLQG 384

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            +  K++ +++          S  + T  TLDRE      + + A D G+PPLS++  V 
Sbjct: 385 EVPFKIISSSK---------NSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
           + + DVNDN P+F +  Y  ++ E+ P G    QV ASD D GL G + YS+    L   
Sbjct: 436 LHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPL 495

Query: 711 APQAF-RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDN 767
           A  ++  +    G +   +  D E+   T++L ++A+D G   LSA   +RV + D NDN
Sbjct: 496 ALASYVSMSAQSGVVFAQRAFDYEQ-LRTFELTLQARDQGSPALSANVSLRVLVGDRNDN 554

Query: 768 -----HPVFNP--STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 820
                +P   P  S     +    +PG  +  V+A D DSG    ++Y ++  +   LF+
Sbjct: 555 APRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFS 614

Query: 821 IDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI 866
           +   TG +     L   ++    L+V+ +DGG     ++A  T+H+
Sbjct: 615 LGLRTGEVRTARALGDRDAARQRLLVAVRDGG--QPPLSATATLHL 658



 Score =  179 bits (455), Expect = 1e-44
 Identities = 172/608 (28%), Positives = 267/608 (43%), Gaps = 41/608 (6%)

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRE----RDPATYDLLVEAKDGGGLSAQAFVRVDLE 762
            +S E P  F +    G++ VS  +DRE    + PA   L  EA     L+    V V++E
Sbjct: 68   VSSEKPY-FTVSAESGELLVSSRLDREEICGKKPACA-LEFEAVAENPLNFY-HVNVEIE 124

Query: 763  DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 822
            D+ND+ P F  +++   IS+  QPGT  I  +A D D G+     Y+L      SL   +
Sbjct: 125  DINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKE 184

Query: 823  STTGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFER 878
               G  Y  L L       + +   L+++A DGG        ++ I +      P  F R
Sbjct: 185  KQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244

Query: 879  PKYTFLVYEDVPEDSPIGTVKAR---EPLNSSEPI-FYRISSGDLGGKFSIHPRLGTIRT 934
              Y   + E+VP  + +  V A    E +NS     FYR      G  FS++ + G I T
Sbjct: 245  DVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRT-----GQIFSLNSKSGEITT 299

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
            +K LD E      + V+ + G       T V I + D NDN P     S    I +   P
Sbjct: 300  QKKLDFEETKEYSMVVEGRDGGGLVAQCT-VEINIQDENDNSPEVTFHSLLEMILENAVP 358

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
            GT + L +  D+DSG NG +   +    P  + +  +    L  +G+L   +  E  +T+
Sbjct: 359  GTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418

Query: 1054 RAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL- 1111
             A D+G  P  +++ V+  + +  +++P   F    Y V V E+  P   + Q  A  L 
Sbjct: 419  TATDRGKPPLSSSISVILHIRDVNDNAP--VFHQASYLVSVPENNPPGASIAQVCASDLD 476

Query: 1112 ---GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
                 Q + S +   LEP   ++   +   +G ++ +R FDYE  +T+   + A      
Sbjct: 477  LGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSP 536

Query: 1169 FLQ-NVSTTVIVRVWDENDNSPTFLH-------DVLFLKVEESPVPQGVIGKITAIDMDS 1220
             L  NVS  V+V   D NDN+P  L+         LF  V  +  P  ++ K+ A+D DS
Sbjct: 537  ALSANVSLRVLVG--DRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594

Query: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G N  L Y +L  S+   F +   TGE+    AL         + V V D G PP +AT 
Sbjct: 595  GHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATA 654

Query: 1279 AVYVSVTD 1286
             +++   D
Sbjct: 655  TLHLVFAD 662



 Score =  166 bits (421), Expect = 1e-40
 Identities = 142/518 (27%), Positives = 235/518 (45%), Gaps = 51/518 (9%)

Query: 592  LQSKMVHTAECGPSFAIDSESGAISTIRTLDREV------QEAVELKVVAQDLGEPPLSA 645
            L ++ +  +   P F + +ESG +     LDRE         A+E + VA++    PL+ 
Sbjct: 61   LPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAEN----PLNF 116

Query: 646  TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
               V++ ++D+ND+ P F +  +   I+E A  G  F+   A DAD GL    +Y L   
Sbjct: 117  YH-VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL--- 172

Query: 706  FLSYEAPQAFRI---DPHDG----QICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAF 756
                    +F +   +  DG    ++ + + +DRE+  + + L++ A DGG   LS    
Sbjct: 173  ----SLNPSFSLIIKEKQDGSKYPELALEKTLDREQQ-SYHRLVLTALDGGHPPLSGTTE 227

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            +R+ + D NDN PVFN   Y  S+ +   PGT ++ V ATDQD GI   + Y        
Sbjct: 228  LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFY--RTG 285

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
             +F+++S +G I     L   E+   S++V  +DGGGL A    ++ I            
Sbjct: 286  QIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQ-------DEND 338

Query: 877  ERPKYTF-----LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGK-FSIHPRLG 930
              P+ TF     ++ E+    + I  +K  +  +           G++  K  S      
Sbjct: 339  NSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398

Query: 931  TIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 989
             + T   LD E  P   +T+ A   G  P  SS  V + + DVNDN P F + S  + + 
Sbjct: 399  KLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVP 458

Query: 990  QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ------PGVFAIDRALGVLFLNGSLGA 1043
            +  PPG ++    A D D G NG + YSI +            ++    GV+F   +   
Sbjct: 459  ENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDY 518

Query: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSP 1080
             + R   LTL+A DQG    +A + L V++ ++ +++P
Sbjct: 519  EQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556



 Score =  164 bits (414), Expect = 7e-40
 Identities = 139/496 (28%), Positives = 226/496 (45%), Gaps = 28/496 (5%)

Query: 873  PAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTI 932
            PA  E+ +Y   + E++P+ S +G +      +  E    ++        F++    G +
Sbjct: 27   PALCEQIRYR--IPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGEL 84

Query: 933  RTRKPLDHET----QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRI 988
                 LD E     +P   L  +A   +    +   VN+ + D+ND+ P F + S E++I
Sbjct: 85   LVSSRLDREEICGKKPACALEFEAVAENP--LNFYHVNVEIEDINDHTPKFTQNSFELQI 142

Query: 989  SQTTPPGTALYLARAEDRDSGRNGLIRYSIA-SPQPGVFAIDRALGV----LFLNGSLGA 1043
            S++  PGT   L  AED D G N L +Y ++ +P   +   ++  G     L L  +L  
Sbjct: 143  SESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDR 202

Query: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
             +Q    L L A D G  P +    L + +     +P   F   VY+V + E++ P T +
Sbjct: 203  EQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPP-VFNRDVYRVSLRENVPPGTTV 261

Query: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
            LQ  A     +   S + YS   +    +F +   +G I  +++ D+E T+ Y+  V   
Sbjct: 262  LQVSATDQD-EGINSEITYSFYRT--GQIFSLNSKSGEITTQKKLDFEETKEYSMVVEG- 317

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
               DG       TV + + DENDNSP      L   + E+ VP  +I  I   D DSG+N
Sbjct: 318  --RDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGEN 375

Query: 1224 GQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
            G++   L  +  F     + N+ +L+    LDRE    + +T+  TDRG PP +++++V 
Sbjct: 376  GEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV--SS 1339
            + + D+NDN P F Q        V V E  P    +  V A D D G N +V+YS+  S 
Sbjct: 436  LHIRDVNDNAPVFHQA----SYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASD 491

Query: 1340 ARPMPLKGKTAFGKQS 1355
              P+ L    +   QS
Sbjct: 492  LEPLALASYVSMSAQS 507



 Score =  137 bits (346), Expect = 5e-32
 Identities = 147/584 (25%), Positives = 235/584 (40%), Gaps = 41/584 (7%)

Query: 783  ETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTL 842
            E  P   ++  LATD    +      +L   +    FT+ + +G + ++  L   E    
Sbjct: 39   EEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGK 98

Query: 843  SLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE--------------- 887
                + +      AV    +  +     +       PK+T   +E               
Sbjct: 99   KPACALE----FEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFIL 154

Query: 888  DVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 947
            +V ED+ IG    ++   S  P F  I      G  S +P L   +T   LD E Q    
Sbjct: 155  EVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDG--SKYPELALEKT---LDREQQSYHR 209

Query: 948  LTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR 1006
            L + A  G  P  S +TE+ I V D NDN P F R    + + +  PPGT +    A D+
Sbjct: 210  LVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQ 269

Query: 1007 DSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAAL 1066
            D G N  I YS       +F+++   G +     L   E +E ++ +   D G       
Sbjct: 270  DEGINSEITYSFYRTGQ-IFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCT 328

Query: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
            + + +  ++ ++SP  TF  L+  +   E+  P T +   + H          +   L+ 
Sbjct: 329  VEINIQ-DENDNSPEVTFHSLLEMI--LENAVPGTLIALIKIHDQDSGENGE-VNCQLQG 384

Query: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 1186
             V   +      +  +      D E T  YN  + A       L + S +VI+ + D ND
Sbjct: 385  EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSS-SISVILHIRDVND 443

Query: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-------GKFFKM 1239
            N+P F      + V E+  P   I ++ A D+D G NGQ+ Y +++          +  M
Sbjct: 444  NAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSM 503

Query: 1240 NPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP--FFPQC 1297
            +  +G +    A D E     E+T+   D+GSP  +A +++ V V D NDN P   +P  
Sbjct: 504  SAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPAL 563

Query: 1298 LP-GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
             P G  L   V        LVT V A D D G+NA ++Y V  A
Sbjct: 564  GPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQA 607


>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  261 bits (668), Expect = 2e-69
 Identities = 219/711 (30%), Positives = 323/711 (45%), Gaps = 105/711 (14%)

Query: 73  VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
           + E +P  ++VG++   L  + Q+  +       S + P    F V  ++G +  + RLD
Sbjct: 37  IPEEMPKGSVVGNLATDLGFSVQELPTRKL--RVSSEKPY---FTVSAESGELLVSSRLD 91

Query: 133 RERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
           RE         A    AV +       V + + D+NDH+P+F  +S +L +SE + PGT 
Sbjct: 92  REEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR 151

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
           F L VA D D GL S Q Y L            P F L  +           GS  P   
Sbjct: 152 FILEVAEDADIGLNSLQKYKL---------SLNPSFSLIIKEKQD-------GSKYP--- 192

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
            +L L + LDRE+ + HRL + A DGG P  +G   + ++V D NDNPPVF +D YR ++
Sbjct: 193 -ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSL 251

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           RE+  PG  V +V ATD+D G N  + YS  R  Q+               F++   SG 
Sbjct: 252 RENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI---------------FSLNSKSGE 296

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           +   + LD E    + +VVE RDGG    VA   V I + D NDN P +    L E    
Sbjct: 297 ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLE---- 350

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
            + E A PG  +A + + D D         +GE      +G ++  L+ GE  F ++   
Sbjct: 351 MILENAVPGTLIALIKIHDQD---------SGE------NGEVNCQLQ-GEVPFKII-SS 393

Query: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544
               + L  +G LDRE    Y + + ATD G PPLS+  +++L + D+ND  P+F Q  Y
Sbjct: 394 SKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASY 453

Query: 545 KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604
             SV E   PG  +  V ASD D             + L+   +   + S +   A    
Sbjct: 454 LVSVPENNPPGASIAQVCASDLD-------------LGLNGQVSYSIMASDLEPLA-LAS 499

Query: 605 SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
             ++ ++SG +   R  D E     EL + A+D G P LSA   + + V D NDN P   
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP--- 556

Query: 665 RQVYNA----------TIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714
           R +Y A           +   A  G+   +V A DADSG   ++ Y +    L    P  
Sbjct: 557 RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV----LQASEPGL 612

Query: 715 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLED 763
           F +    G++  ++ +  +RD A   LLV  +DGG   LSA A + +   D
Sbjct: 613 FSLGLRTGEVRTARALG-DRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662



 Score =  189 bits (479), Expect = 2e-47
 Identities = 174/646 (26%), Positives = 278/646 (43%), Gaps = 96/646 (14%)

Query: 247 DLVLLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
           +L++  RLDREE    +    L+ EA             V + + D ND+ P F Q+ + 
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAV---AENPLNFYHVNVEIEDINDHTPKFTQNSFE 139

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             + E AQPG       A D D+G N   +Y +             +L  +    ++E  
Sbjct: 140 LQISESAQPGTRFILEVAEDADIGLNSLQKYKL-------------SLNPSFSLIIKEKQ 186

Query: 363 G-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
                  + + + LDRE Q++H+LV+ A DGG  P   T  + I V D NDN P  +   
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN--- 243

Query: 418 LTEGGVARVS--EGARPGDYVARVSVSDADGDWEKEDE----ATGELGVGLGDGSISLSL 471
                V RVS  E   PG  V +VS +D D     E       TG++         SL+ 
Sbjct: 244 ---RDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI--------FSLNS 292

Query: 472 EGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
           + GE               +  +  LD E    Y +++   D G   L  + T+ + + D
Sbjct: 293 KSGE---------------ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQD 335

Query: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-G 590
            ND  P  +       + E A PGT++  +   D D   +               C L G
Sbjct: 336 ENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV-----------NCQLQG 384

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            +  K++ +++          S  + T  TLDRE      + + A D G+PPLS++  V 
Sbjct: 385 EVPFKIISSSK---------NSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYE 710
           + + DVNDN P+F +  Y  ++ E+ P G    QV ASD D GL G + YS+    L   
Sbjct: 436 LHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPL 495

Query: 711 APQAF-RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDN 767
           A  ++  +    G +   +  D E+   T++L ++A+D G   LSA   +RV + D NDN
Sbjct: 496 ALASYVSMSAQSGVVFAQRAFDYEQ-LRTFELTLQARDQGSPALSANVSLRVLVGDRNDN 554

Query: 768 -----HPVFNP--STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 820
                +P   P  S     +    +PG  +  V+A D DSG    ++Y ++  +   LF+
Sbjct: 555 APRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFS 614

Query: 821 IDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI 866
           +   TG +     L   ++    L+V+ +DGG     ++A  T+H+
Sbjct: 615 LGLRTGEVRTARALGDRDAARQRLLVAVRDGG--QPPLSATATLHL 658



 Score =  179 bits (455), Expect = 1e-44
 Identities = 172/608 (28%), Positives = 267/608 (43%), Gaps = 41/608 (6%)

Query: 707  LSYEAPQAFRIDPHDGQICVSQDIDRE----RDPATYDLLVEAKDGGGLSAQAFVRVDLE 762
            +S E P  F +    G++ VS  +DRE    + PA   L  EA     L+    V V++E
Sbjct: 68   VSSEKPY-FTVSAESGELLVSSRLDREEICGKKPACA-LEFEAVAENPLNFY-HVNVEIE 124

Query: 763  DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 822
            D+ND+ P F  +++   IS+  QPGT  I  +A D D G+     Y+L      SL   +
Sbjct: 125  DINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKE 184

Query: 823  STTGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFER 878
               G  Y  L L       + +   L+++A DGG        ++ I +      P  F R
Sbjct: 185  KQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244

Query: 879  PKYTFLVYEDVPEDSPIGTVKAR---EPLNSSEPI-FYRISSGDLGGKFSIHPRLGTIRT 934
              Y   + E+VP  + +  V A    E +NS     FYR      G  FS++ + G I T
Sbjct: 245  DVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRT-----GQIFSLNSKSGEITT 299

Query: 935  RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
            +K LD E      + V+ + G       T V I + D NDN P     S    I +   P
Sbjct: 300  QKKLDFEETKEYSMVVEGRDGGGLVAQCT-VEINIQDENDNSPEVTFHSLLEMILENAVP 358

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
            GT + L +  D+DSG NG +   +    P  + +  +    L  +G+L   +  E  +T+
Sbjct: 359  GTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418

Query: 1054 RAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL- 1111
             A D+G  P  +++ V+  + +  +++P   F    Y V V E+  P   + Q  A  L 
Sbjct: 419  TATDRGKPPLSSSISVILHIRDVNDNAP--VFHQASYLVSVPENNPPGASIAQVCASDLD 476

Query: 1112 ---GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
                 Q + S +   LEP   ++   +   +G ++ +R FDYE  +T+   + A      
Sbjct: 477  LGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSP 536

Query: 1169 FLQ-NVSTTVIVRVWDENDNSPTFLH-------DVLFLKVEESPVPQGVIGKITAIDMDS 1220
             L  NVS  V+V   D NDN+P  L+         LF  V  +  P  ++ K+ A+D DS
Sbjct: 537  ALSANVSLRVLVG--DRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594

Query: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
            G N  L Y +L  S+   F +   TGE+    AL         + V V D G PP +AT 
Sbjct: 595  GHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATA 654

Query: 1279 AVYVSVTD 1286
             +++   D
Sbjct: 655  TLHLVFAD 662



 Score =  166 bits (421), Expect = 1e-40
 Identities = 142/518 (27%), Positives = 235/518 (45%), Gaps = 51/518 (9%)

Query: 592  LQSKMVHTAECGPSFAIDSESGAISTIRTLDREV------QEAVELKVVAQDLGEPPLSA 645
            L ++ +  +   P F + +ESG +     LDRE         A+E + VA++    PL+ 
Sbjct: 61   LPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAEN----PLNF 116

Query: 646  TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG 705
               V++ ++D+ND+ P F +  +   I+E A  G  F+   A DAD GL    +Y L   
Sbjct: 117  YH-VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL--- 172

Query: 706  FLSYEAPQAFRI---DPHDG----QICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAF 756
                    +F +   +  DG    ++ + + +DRE+  + + L++ A DGG   LS    
Sbjct: 173  ----SLNPSFSLIIKEKQDGSKYPELALEKTLDREQQ-SYHRLVLTALDGGHPPLSGTTE 227

Query: 757  VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVS 816
            +R+ + D NDN PVFN   Y  S+ +   PGT ++ V ATDQD GI   + Y        
Sbjct: 228  LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFY--RTG 285

Query: 817  SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
             +F+++S +G I     L   E+   S++V  +DGGGL A    ++ I            
Sbjct: 286  QIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQ-------DEND 338

Query: 877  ERPKYTF-----LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGK-FSIHPRLG 930
              P+ TF     ++ E+    + I  +K  +  +           G++  K  S      
Sbjct: 339  NSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398

Query: 931  TIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 989
             + T   LD E  P   +T+ A   G  P  SS  V + + DVNDN P F + S  + + 
Sbjct: 399  KLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVP 458

Query: 990  QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ------PGVFAIDRALGVLFLNGSLGA 1043
            +  PPG ++    A D D G NG + YSI +            ++    GV+F   +   
Sbjct: 459  ENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDY 518

Query: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSP 1080
             + R   LTL+A DQG    +A + L V++ ++ +++P
Sbjct: 519  EQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556



 Score =  164 bits (414), Expect = 7e-40
 Identities = 139/496 (28%), Positives = 226/496 (45%), Gaps = 28/496 (5%)

Query: 873  PAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTI 932
            PA  E+ +Y   + E++P+ S +G +      +  E    ++        F++    G +
Sbjct: 27   PALCEQIRYR--IPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGEL 84

Query: 933  RTRKPLDHET----QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRI 988
                 LD E     +P   L  +A   +    +   VN+ + D+ND+ P F + S E++I
Sbjct: 85   LVSSRLDREEICGKKPACALEFEAVAENP--LNFYHVNVEIEDINDHTPKFTQNSFELQI 142

Query: 989  SQTTPPGTALYLARAEDRDSGRNGLIRYSIA-SPQPGVFAIDRALGV----LFLNGSLGA 1043
            S++  PGT   L  AED D G N L +Y ++ +P   +   ++  G     L L  +L  
Sbjct: 143  SESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDR 202

Query: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
             +Q    L L A D G  P +    L + +     +P   F   VY+V + E++ P T +
Sbjct: 203  EQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPP-VFNRDVYRVSLRENVPPGTTV 261

Query: 1104 LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 1163
            LQ  A     +   S + YS   +    +F +   +G I  +++ D+E T+ Y+  V   
Sbjct: 262  LQVSATDQD-EGINSEITYSFYRT--GQIFSLNSKSGEITTQKKLDFEETKEYSMVVEG- 317

Query: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 1223
               DG       TV + + DENDNSP      L   + E+ VP  +I  I   D DSG+N
Sbjct: 318  --RDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGEN 375

Query: 1224 GQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
            G++   L  +  F     + N+ +L+    LDRE    + +T+  TDRG PP +++++V 
Sbjct: 376  GEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV--SS 1339
            + + D+NDN P F Q        V V E  P    +  V A D D G N +V+YS+  S 
Sbjct: 436  LHIRDVNDNAPVFHQA----SYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASD 491

Query: 1340 ARPMPLKGKTAFGKQS 1355
              P+ L    +   QS
Sbjct: 492  LEPLALASYVSMSAQS 507



 Score =  137 bits (346), Expect = 5e-32
 Identities = 147/584 (25%), Positives = 235/584 (40%), Gaps = 41/584 (7%)

Query: 783  ETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTL 842
            E  P   ++  LATD    +      +L   +    FT+ + +G + ++  L   E    
Sbjct: 39   EEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGK 98

Query: 843  SLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE--------------- 887
                + +      AV    +  +     +       PK+T   +E               
Sbjct: 99   KPACALE----FEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFIL 154

Query: 888  DVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 947
            +V ED+ IG    ++   S  P F  I      G  S +P L   +T   LD E Q    
Sbjct: 155  EVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDG--SKYPELALEKT---LDREQQSYHR 209

Query: 948  LTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR 1006
            L + A  G  P  S +TE+ I V D NDN P F R    + + +  PPGT +    A D+
Sbjct: 210  LVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQ 269

Query: 1007 DSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAAL 1066
            D G N  I YS       +F+++   G +     L   E +E ++ +   D G       
Sbjct: 270  DEGINSEITYSFYRTGQ-IFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCT 328

Query: 1067 LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP 1126
            + + +  ++ ++SP  TF  L+  +   E+  P T +   + H          +   L+ 
Sbjct: 329  VEINIQ-DENDNSPEVTFHSLLEMI--LENAVPGTLIALIKIHDQDSGENGE-VNCQLQG 384

Query: 1127 SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDEND 1186
             V   +      +  +      D E T  YN  + A       L + S +VI+ + D ND
Sbjct: 385  EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSS-SISVILHIRDVND 443

Query: 1187 NSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-------GKFFKM 1239
            N+P F      + V E+  P   I ++ A D+D G NGQ+ Y +++          +  M
Sbjct: 444  NAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSM 503

Query: 1240 NPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRP--FFPQC 1297
            +  +G +    A D E     E+T+   D+GSP  +A +++ V V D NDN P   +P  
Sbjct: 504  SAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPAL 563

Query: 1298 LP-GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
             P G  L   V        LVT V A D D G+NA ++Y V  A
Sbjct: 564  GPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQA 607


>gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precursor
           [Homo sapiens]
          Length = 863

 Score =  260 bits (664), Expect = 7e-69
 Identities = 216/661 (32%), Positives = 307/661 (46%), Gaps = 82/661 (12%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F V+ +TG +    RLDRE            L  VV+       VE+ + D+ND++P FP
Sbjct: 77  FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFP 136

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              ++L++SE   PGT F L  AHDPD G  S Q Y L +           +F LR +T 
Sbjct: 137 TQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSR---------NEYFALRVQT- 186

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                          +  +LVL R LDRE   + +L + A DGG P  +  L + ++VLD
Sbjct: 187 ----------REDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLD 236

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN PVF Q  YRA V EDA  G  V +V ATD D GPNG + YS         GS   
Sbjct: 237 ANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSF--------GSHNR 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
           A G    FA++ ++G++ +   LD E    H++ ++A+D GA PE A  +V + V+DVND
Sbjct: 289 A-GVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVND 347

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P I V  +     + V E A  G  +A +SV+D D    +    T E+  GL   S++
Sbjct: 348 NAPEITVTSV----YSPVPEDAPLGTVIALLSVTDLDAG--ENGLVTCEVPPGL-PFSLT 400

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
            SL+                F L     LDRE+   Y L + A DAG+P LS    + ++
Sbjct: 401 SSLK--------------NYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQ 446

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           V+D+ND PP  SQ  Y   + E   PG  ++ +S  D D     +A L + +++  A   
Sbjct: 447 VSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPD--APQNARLSFFLLEQGA--- 501

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                     T   G  F I+ ++G +S++  LD E +   EL     D G P L+    
Sbjct: 502 ---------ETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNIS 552

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAP----VGHCFLQVTASDADSGLYGFIEYSLYD 704
           V+I V D NDN P         +  E  P     GH   +V   DAD+G   ++ YSL  
Sbjct: 553 VNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSL-- 610

Query: 705 GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLE 762
             L       F I  H GQI  ++ + ++ D     L V  KD G   LS  A + V + 
Sbjct: 611 --LGSPNQSLFAIGLHTGQISTARPV-QDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVT 667

Query: 763 D 763
           +
Sbjct: 668 E 668



 Score =  162 bits (410), Expect = 2e-39
 Identities = 174/617 (28%), Positives = 259/617 (41%), Gaps = 76/617 (12%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           L SVE+ + D NDN P F   E +  + E   PG       A D D+G N    Y +   
Sbjct: 118 LFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRN 177

Query: 339 QVPGAGSGGGALGDAAYFAVEELS-------GVVRVWRPLDREAQAWHQLVVEARDGGAE 391
           +               YFA+   +         + + R LDRE +   QLV+ A DGG  
Sbjct: 178 E---------------YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTP 222

Query: 392 PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
              A++ + I VLD NDN P  +         ARV E A  G  V +V  +D D      
Sbjct: 223 ALSASLPIHIKVLDANDNAPVFNQSLYR----ARVLEDAPSGTRVVQVLATDLD------ 272

Query: 452 DEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
           +   GE+    G    S +  G    FAL L  G      L ++G LD E   L+E+ + 
Sbjct: 273 EGPNGEIIYSFG----SHNRAGVRQLFALDLVTG-----MLTIKGRLDFEDTKLHEIYIQ 323

Query: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
           A D G+ P      +L+ V D+ND  P  +     + V E A  GTV+  +S +D D AG
Sbjct: 324 AKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLD-AG 382

Query: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
            +       +V    P  L                F++ S      T++T   LDRE   
Sbjct: 383 ENG------LVTCEVPPGL---------------PFSLTSSLKNYFTLKTSADLDRETVP 421

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
              L + A+D G P LSA  +V + V D+NDN P   +  Y+  I E+   G   L ++ 
Sbjct: 422 EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSV 481

Query: 688 SDADSGLYGFIEYSLYD-GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAK 746
            D D+     + + L + G  +    + F I+  +G +     +D E D   ++L     
Sbjct: 482 WDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYE-DRREFELTAHIS 540

Query: 747 DGGG--LSAQAFVRVDLEDVNDNHP-VFNP---STYVTSISDETQPGTEIINVLATDQDS 800
           DGG   L+    V + + D NDN P V  P    + V  +   T  G  +  V+  D D+
Sbjct: 541 DGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADA 600

Query: 801 GIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINA 860
           G    ++Y L+     SLF I   TG I    P+   +S   +L V  +D G  +    A
Sbjct: 601 GHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTA 660

Query: 861 DVTIHIFQ-TTLAPAEF 876
            +T+ + + +  A AEF
Sbjct: 661 TLTVSVTEDSPEARAEF 677



 Score =  148 bits (374), Expect = 3e-35
 Identities = 140/517 (27%), Positives = 229/517 (44%), Gaps = 32/517 (6%)

Query: 588  NLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPP 642
            +LGSL ++       G S   F ++ E+G +     LDRE          V  + + E P
Sbjct: 57   DLGSLSARRFRVVS-GASRRFFEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENP 115

Query: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSL 702
            L     V + + D+NDN P F  Q     I+E    G  F   +A D D G      Y L
Sbjct: 116  LELFS-VEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYEL 174

Query: 703  YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVD 760
                      Q         ++ + + +DRER+P+   L++ A DGG   LSA   + + 
Sbjct: 175  SRNEYFALRVQTREDSTKYAELVLERALDREREPSL-QLVLTALDGGTPALSASLPIHIK 233

Query: 761  LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN---VSS 817
            + D NDN PVFN S Y   + ++   GT ++ VLATD D G  G + Y     N   V  
Sbjct: 234  VLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQ 293

Query: 818  LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
            LF +D  TG++ +   L   ++    + + A+D G      +  V + +           
Sbjct: 294  LFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEV-----VDVNDN 348

Query: 878  RPKYTFL-VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL--GGKFSIHPRLG---T 931
             P+ T   VY  VPED+P+GTV A   +   +     + + ++  G  FS+   L    T
Sbjct: 349  APEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFT 408

Query: 932  IRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQ 990
            ++T   LD ET P   L++ A+    P+ S+ T V + V D+NDN P   ++S ++ I +
Sbjct: 409  LKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEE 468

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYSI--ASPQPGV----FAIDRALGVLFLNGSLGAG 1044
               PG  +      D D+ +N  + + +     + G+    F I+R  G++     L   
Sbjct: 469  NNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYE 528

Query: 1045 EQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSP 1080
            ++RE  LT    D G    A  + + + V ++ +++P
Sbjct: 529  DRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAP 565



 Score =  146 bits (369), Expect = 1e-34
 Identities = 149/587 (25%), Positives = 251/587 (42%), Gaps = 42/587 (7%)

Query: 780  ISDETQPGTEIINVLAT-DQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
            I +E + G  + NV+A    D G      + ++ G     F ++  TG +++   L   E
Sbjct: 37   IPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREE 96

Query: 839  --------STTLSLMVSAQDGGGLTAVINADVTIH--IFQTT---LAPAEFERPKYTFLV 885
                    + TL L+V          V+  D+  +   F T    L  +E   P   F +
Sbjct: 97   LCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPL 156

Query: 886  YEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 945
                  D    +++  E L+ +E    R+ + +   K++       +   + LD E +P 
Sbjct: 157  ESAHDPDVGSNSLQTYE-LSRNEYFALRVQTREDSTKYA------ELVLERALDREREPS 209

Query: 946  VVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
            + L + A  G  PA S S  ++I V+D NDN P F ++    R+ +  P GT +    A 
Sbjct: 210  LQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLAT 269

Query: 1005 DRDSGRNGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060
            D D G NG I YS  S        +FA+D   G+L + G L   + +   + ++A+D+G 
Sbjct: 270  DLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGA 329

Query: 1061 HPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
            +P+ A   VL  V++  +++P  T   +   V     L  +  +L       G     + 
Sbjct: 330  NPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVT- 388

Query: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
                + P +  ++         +      D E+   YN  + A    D    ++S   IV
Sbjct: 389  --CEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITA---RDAGTPSLSALTIV 443

Query: 1180 RVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--- 1234
            RV   D NDN P        + +EE+ +P   I  ++  D D+ +N +L +FLL  G   
Sbjct: 444  RVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAET 503

Query: 1235 ----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
                ++F +N + G + + V LD E R   E+T  ++D G+P     ++V + VTD NDN
Sbjct: 504  GLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDN 563

Query: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             P      PG      +  G     LV+ V   D D G+NA ++YS+
Sbjct: 564  APQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSL 610



 Score =  135 bits (341), Expect = 2e-31
 Identities = 166/623 (26%), Positives = 261/623 (41%), Gaps = 63/623 (10%)

Query: 715  FRIDPHDGQICVSQDIDRER-------DPATYDLLVEAKDGGGLSAQAF-VRVDLEDVND 766
            F ++   G++ V+  +DRE           T +L+VE         + F V V ++D+ND
Sbjct: 77   FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENP------LELFSVEVVIQDIND 130

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF--TIDST 824
            N+P F        IS+   PGT      A D D G      YEL      +L   T + +
Sbjct: 131  NNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDS 190

Query: 825  TGIIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL---APAEFERP 879
            T    L L   L      +L L+++A DGG  T  ++A + IHI        AP  F + 
Sbjct: 191  TKYAELVLERALDREREPSLQLVLTALDGG--TPALSASLPIHIKVLDANDNAPV-FNQS 247

Query: 880  KYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTR 935
             Y   V ED P  + +  V A +     +  I Y   S +  G    F++    G +  +
Sbjct: 248  LYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIK 307

Query: 936  KPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
              LD E   +  + +QA+  G+ P  +  +V + V+DVNDN P    TS    + +  P 
Sbjct: 308  GRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPL 367

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTL 1051
            GT + L    D D+G NGL+   +    P  F++  +L   F    +  L      E  L
Sbjct: 368  GTVIALLSVTDLDAGENGLVTCEVPPGLP--FSLTSSLKNYFTLKTSADLDRETVPEYNL 425

Query: 1052 TLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA-HP 1110
            ++ A D G    +AL ++ V +     +P  + +   Y V + E+  P   +L      P
Sbjct: 426  SITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSS-YDVYIEENNLPGAPILNLSVWDP 484

Query: 1111 LGPQRAASPLRYSLEPSVDSAMFG----IRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
              PQ A     + LE   ++ + G    I    G +      DYE  +   F + A I +
Sbjct: 485  DAPQNARLSF-FLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRR--EFELTAHISD 541

Query: 1167 DG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV---PQG-----VIGKITA 1215
             G      N+S  + V   D NDN+P     VL+ +   S V   P+G     ++ ++  
Sbjct: 542  GGTPVLATNISVNIFVT--DRNDNAP----QVLYPRPGGSSVEMLPRGTSAGHLVSRVVG 595

Query: 1216 IDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPP 1273
             D D+G N  L Y LL   +   F +  +TG++     +         +TVL+ D G P 
Sbjct: 596  WDADAGHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPS 655

Query: 1274 RNATMAVYVSVT-DINDNRPFFP 1295
             + T  + VSVT D  + R  FP
Sbjct: 656  LSTTATLTVSVTEDSPEARAEFP 678



 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%)

Query: 1176 TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK 1235
            +V V + D NDN+P F    + L++ E+  P       +A D D G N  L  + LS  +
Sbjct: 120  SVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNS-LQTYELSRNE 178

Query: 1236 FFKMNPNT-------GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
            +F +   T        EL+   ALDRE     ++ +   D G+P  +A++ +++ V D N
Sbjct: 179  YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDAN 238

Query: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
            DN P F Q L       +VLE  P    V  V A D DEG N E+ YS  S
Sbjct: 239  DNAPVFNQSL----YRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGS 285



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 8/159 (5%)

Query: 1195 VLFLKVEESPVPQGVIGKITA-IDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVA 1251
            V+  ++ E       +G + A + +D G      + ++S    +FF++N  TGE+     
Sbjct: 32   VIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDR 91

Query: 1252 LDREHR-GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
            LDRE   G      +  +          +V V + DINDN P FP     +E+ +++ E 
Sbjct: 92   LDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPT----QEMKLEISEA 147

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKT 1349
                       A DPD G+N+  TY +S      L+ +T
Sbjct: 148  VAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQT 186


>gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precursor
           [Homo sapiens]
          Length = 934

 Score =  260 bits (664), Expect = 7e-69
 Identities = 216/661 (32%), Positives = 307/661 (46%), Gaps = 82/661 (12%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F V+ +TG +    RLDRE            L  VV+       VE+ + D+ND++P FP
Sbjct: 77  FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFP 136

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              ++L++SE   PGT F L  AHDPD G  S Q Y L +           +F LR +T 
Sbjct: 137 TQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSR---------NEYFALRVQT- 186

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                          +  +LVL R LDRE   + +L + A DGG P  +  L + ++VLD
Sbjct: 187 ----------REDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLD 236

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN PVF Q  YRA V EDA  G  V +V ATD D GPNG + YS         GS   
Sbjct: 237 ANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSF--------GSHNR 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
           A G    FA++ ++G++ +   LD E    H++ ++A+D GA PE A  +V + V+DVND
Sbjct: 289 A-GVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVND 347

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P I V  +     + V E A  G  +A +SV+D D    +    T E+  GL   S++
Sbjct: 348 NAPEITVTSV----YSPVPEDAPLGTVIALLSVTDLDAG--ENGLVTCEVPPGL-PFSLT 400

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
            SL+                F L     LDRE+   Y L + A DAG+P LS    + ++
Sbjct: 401 SSLK--------------NYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQ 446

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           V+D+ND PP  SQ  Y   + E   PG  ++ +S  D D     +A L + +++  A   
Sbjct: 447 VSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPD--APQNARLSFFLLEQGA--- 501

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                     T   G  F I+ ++G +S++  LD E +   EL     D G P L+    
Sbjct: 502 ---------ETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNIS 552

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAP----VGHCFLQVTASDADSGLYGFIEYSLYD 704
           V+I V D NDN P         +  E  P     GH   +V   DAD+G   ++ YSL  
Sbjct: 553 VNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSL-- 610

Query: 705 GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLE 762
             L       F I  H GQI  ++ + ++ D     L V  KD G   LS  A + V + 
Sbjct: 611 --LGSPNQSLFAIGLHTGQISTARPV-QDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVT 667

Query: 763 D 763
           +
Sbjct: 668 E 668



 Score =  162 bits (410), Expect = 2e-39
 Identities = 174/617 (28%), Positives = 259/617 (41%), Gaps = 76/617 (12%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           L SVE+ + D NDN P F   E +  + E   PG       A D D+G N    Y +   
Sbjct: 118 LFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRN 177

Query: 339 QVPGAGSGGGALGDAAYFAVEELS-------GVVRVWRPLDREAQAWHQLVVEARDGGAE 391
           +               YFA+   +         + + R LDRE +   QLV+ A DGG  
Sbjct: 178 E---------------YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTP 222

Query: 392 PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
              A++ + I VLD NDN P  +         ARV E A  G  V +V  +D D      
Sbjct: 223 ALSASLPIHIKVLDANDNAPVFNQSLYR----ARVLEDAPSGTRVVQVLATDLD------ 272

Query: 452 DEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
           +   GE+    G    S +  G    FAL L  G      L ++G LD E   L+E+ + 
Sbjct: 273 EGPNGEIIYSFG----SHNRAGVRQLFALDLVTG-----MLTIKGRLDFEDTKLHEIYIQ 323

Query: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
           A D G+ P      +L+ V D+ND  P  +     + V E A  GTV+  +S +D D AG
Sbjct: 324 AKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLD-AG 382

Query: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
            +       +V    P  L                F++ S      T++T   LDRE   
Sbjct: 383 ENG------LVTCEVPPGL---------------PFSLTSSLKNYFTLKTSADLDRETVP 421

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
              L + A+D G P LSA  +V + V D+NDN P   +  Y+  I E+   G   L ++ 
Sbjct: 422 EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSV 481

Query: 688 SDADSGLYGFIEYSLYD-GFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAK 746
            D D+     + + L + G  +    + F I+  +G +     +D E D   ++L     
Sbjct: 482 WDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYE-DRREFELTAHIS 540

Query: 747 DGGG--LSAQAFVRVDLEDVNDNHP-VFNP---STYVTSISDETQPGTEIINVLATDQDS 800
           DGG   L+    V + + D NDN P V  P    + V  +   T  G  +  V+  D D+
Sbjct: 541 DGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADA 600

Query: 801 GIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINA 860
           G    ++Y L+     SLF I   TG I    P+   +S   +L V  +D G  +    A
Sbjct: 601 GHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTA 660

Query: 861 DVTIHIFQ-TTLAPAEF 876
            +T+ + + +  A AEF
Sbjct: 661 TLTVSVTEDSPEARAEF 677



 Score =  148 bits (374), Expect = 3e-35
 Identities = 140/517 (27%), Positives = 229/517 (44%), Gaps = 32/517 (6%)

Query: 588  NLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPP 642
            +LGSL ++       G S   F ++ E+G +     LDRE          V  + + E P
Sbjct: 57   DLGSLSARRFRVVS-GASRRFFEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENP 115

Query: 643  LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSL 702
            L     V + + D+NDN P F  Q     I+E    G  F   +A D D G      Y L
Sbjct: 116  LELFS-VEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYEL 174

Query: 703  YDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVD 760
                      Q         ++ + + +DRER+P+   L++ A DGG   LSA   + + 
Sbjct: 175  SRNEYFALRVQTREDSTKYAELVLERALDREREPSL-QLVLTALDGGTPALSASLPIHIK 233

Query: 761  LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN---VSS 817
            + D NDN PVFN S Y   + ++   GT ++ VLATD D G  G + Y     N   V  
Sbjct: 234  VLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQ 293

Query: 818  LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
            LF +D  TG++ +   L   ++    + + A+D G      +  V + +           
Sbjct: 294  LFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEV-----VDVNDN 348

Query: 878  RPKYTFL-VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL--GGKFSIHPRLG---T 931
             P+ T   VY  VPED+P+GTV A   +   +     + + ++  G  FS+   L    T
Sbjct: 349  APEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFT 408

Query: 932  IRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQ 990
            ++T   LD ET P   L++ A+    P+ S+ T V + V D+NDN P   ++S ++ I +
Sbjct: 409  LKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEE 468

Query: 991  TTPPGTALYLARAEDRDSGRNGLIRYSI--ASPQPGV----FAIDRALGVLFLNGSLGAG 1044
               PG  +      D D+ +N  + + +     + G+    F I+R  G++     L   
Sbjct: 469  NNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYE 528

Query: 1045 EQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSP 1080
            ++RE  LT    D G    A  + + + V ++ +++P
Sbjct: 529  DRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAP 565



 Score =  146 bits (369), Expect = 1e-34
 Identities = 149/587 (25%), Positives = 251/587 (42%), Gaps = 42/587 (7%)

Query: 780  ISDETQPGTEIINVLAT-DQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
            I +E + G  + NV+A    D G      + ++ G     F ++  TG +++   L   E
Sbjct: 37   IPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREE 96

Query: 839  --------STTLSLMVSAQDGGGLTAVINADVTIH--IFQTT---LAPAEFERPKYTFLV 885
                    + TL L+V          V+  D+  +   F T    L  +E   P   F +
Sbjct: 97   LCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPL 156

Query: 886  YEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 945
                  D    +++  E L+ +E    R+ + +   K++       +   + LD E +P 
Sbjct: 157  ESAHDPDVGSNSLQTYE-LSRNEYFALRVQTREDSTKYA------ELVLERALDREREPS 209

Query: 946  VVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
            + L + A  G  PA S S  ++I V+D NDN P F ++    R+ +  P GT +    A 
Sbjct: 210  LQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLAT 269

Query: 1005 DRDSGRNGLIRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060
            D D G NG I YS  S        +FA+D   G+L + G L   + +   + ++A+D+G 
Sbjct: 270  DLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGA 329

Query: 1061 HPQAA-LLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
            +P+ A   VL  V++  +++P  T   +   V     L  +  +L       G     + 
Sbjct: 330  NPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVT- 388

Query: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
                + P +  ++         +      D E+   YN  + A    D    ++S   IV
Sbjct: 389  --CEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITA---RDAGTPSLSALTIV 443

Query: 1180 RVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--- 1234
            RV   D NDN P        + +EE+ +P   I  ++  D D+ +N +L +FLL  G   
Sbjct: 444  RVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAET 503

Query: 1235 ----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDN 1290
                ++F +N + G + + V LD E R   E+T  ++D G+P     ++V + VTD NDN
Sbjct: 504  GLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDN 563

Query: 1291 RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
             P      PG      +  G     LV+ V   D D G+NA ++YS+
Sbjct: 564  APQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSL 610



 Score =  135 bits (341), Expect = 2e-31
 Identities = 166/623 (26%), Positives = 261/623 (41%), Gaps = 63/623 (10%)

Query: 715  FRIDPHDGQICVSQDIDRER-------DPATYDLLVEAKDGGGLSAQAF-VRVDLEDVND 766
            F ++   G++ V+  +DRE           T +L+VE         + F V V ++D+ND
Sbjct: 77   FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENP------LELFSVEVVIQDIND 130

Query: 767  NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLF--TIDST 824
            N+P F        IS+   PGT      A D D G      YEL      +L   T + +
Sbjct: 131  NNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDS 190

Query: 825  TGIIYLTLP--LSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTL---APAEFERP 879
            T    L L   L      +L L+++A DGG  T  ++A + IHI        AP  F + 
Sbjct: 191  TKYAELVLERALDREREPSLQLVLTALDGG--TPALSASLPIHIKVLDANDNAPV-FNQS 247

Query: 880  KYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGK---FSIHPRLGTIRTR 935
             Y   V ED P  + +  V A +     +  I Y   S +  G    F++    G +  +
Sbjct: 248  LYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIK 307

Query: 936  KPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 994
              LD E   +  + +QA+  G+ P  +  +V + V+DVNDN P    TS    + +  P 
Sbjct: 308  GRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPL 367

Query: 995  GTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL---NGSLGAGEQRELTL 1051
            GT + L    D D+G NGL+   +    P  F++  +L   F    +  L      E  L
Sbjct: 368  GTVIALLSVTDLDAGENGLVTCEVPPGLP--FSLTSSLKNYFTLKTSADLDRETVPEYNL 425

Query: 1052 TLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA-HP 1110
            ++ A D G    +AL ++ V +     +P  + +   Y V + E+  P   +L      P
Sbjct: 426  SITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSS-YDVYIEENNLPGAPILNLSVWDP 484

Query: 1111 LGPQRAASPLRYSLEPSVDSAMFG----IRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
              PQ A     + LE   ++ + G    I    G +      DYE  +   F + A I +
Sbjct: 485  DAPQNARLSF-FLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRR--EFELTAHISD 541

Query: 1167 DG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV---PQG-----VIGKITA 1215
             G      N+S  + V   D NDN+P     VL+ +   S V   P+G     ++ ++  
Sbjct: 542  GGTPVLATNISVNIFVT--DRNDNAP----QVLYPRPGGSSVEMLPRGTSAGHLVSRVVG 595

Query: 1216 IDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPP 1273
             D D+G N  L Y LL   +   F +  +TG++     +         +TVL+ D G P 
Sbjct: 596  WDADAGHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPS 655

Query: 1274 RNATMAVYVSVT-DINDNRPFFP 1295
             + T  + VSVT D  + R  FP
Sbjct: 656  LSTTATLTVSVTEDSPEARAEFP 678



 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%)

Query: 1176 TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK 1235
            +V V + D NDN+P F    + L++ E+  P       +A D D G N  L  + LS  +
Sbjct: 120  SVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNS-LQTYELSRNE 178

Query: 1236 FFKMNPNT-------GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
            +F +   T        EL+   ALDRE     ++ +   D G+P  +A++ +++ V D N
Sbjct: 179  YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDAN 238

Query: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
            DN P F Q L       +VLE  P    V  V A D DEG N E+ YS  S
Sbjct: 239  DNAPVFNQSL----YRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGS 285



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 8/159 (5%)

Query: 1195 VLFLKVEESPVPQGVIGKITA-IDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVA 1251
            V+  ++ E       +G + A + +D G      + ++S    +FF++N  TGE+     
Sbjct: 32   VIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDR 91

Query: 1252 LDREHR-GHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 1310
            LDRE   G      +  +          +V V + DINDN P FP     +E+ +++ E 
Sbjct: 92   LDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPT----QEMKLEISEA 147

Query: 1311 QPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLKGKT 1349
                       A DPD G+N+  TY +S      L+ +T
Sbjct: 148  VAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQT 186


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,843,697
Number of Sequences: 37866
Number of extensions: 2853078
Number of successful extensions: 20661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 7053
Number of HSP's gapped (non-prelim): 2096
length of query: 1369
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1254
effective length of database: 13,892,928
effective search space: 17421731712
effective search space used: 17421731712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.