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Search of human proteins with 215598574
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
(1897 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 3758 0.0
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 3658 0.0
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 3644 0.0
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 3639 0.0
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 2980 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 1784 0.0
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 1769 0.0
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 1753 0.0
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 1690 0.0
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens] 775 0.0
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 332 2e-90
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 327 9e-89
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 315 2e-85
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 305 2e-82
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 297 8e-80
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 296 1e-79
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 294 6e-79
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 235 4e-61
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 228 6e-59
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 223 1e-57
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 223 1e-57
gi|34304381 inversin isoform a [Homo sapiens] 199 2e-50
gi|34304379 inversin isoform b [Homo sapiens] 199 2e-50
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 197 6e-50
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 196 2e-49
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 191 4e-48
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 187 6e-47
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 182 4e-45
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 182 4e-45
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 169 3e-41
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 3758 bits (9745), Expect = 0.0
Identities = 1897/1897 (100%), Positives = 1897/1897 (100%)
Query: 1 MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK 60
MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK
Sbjct: 1 MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK 60
Query: 61 ALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAAL 120
ALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAAL
Sbjct: 61 ALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAAL 120
Query: 121 AGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
AGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP
Sbjct: 121 AGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
Query: 181 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240
LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF
Sbjct: 181 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240
Query: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM
Sbjct: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK
Sbjct: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
Query: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
Query: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL
Sbjct: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
Query: 721 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780
IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT
Sbjct: 721 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780
Query: 781 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFP 840
DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFP
Sbjct: 781 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFP 840
Query: 841 ETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAI 900
ETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAI
Sbjct: 841 ETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAI 900
Query: 901 PRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMV 960
PRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMV
Sbjct: 901 PRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMV 960
Query: 961 DARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALG 1020
DARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALG
Sbjct: 961 DARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALG 1020
Query: 1021 PTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEE 1080
PTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEE
Sbjct: 1021 PTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEE 1080
Query: 1081 LGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENA 1140
LGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENA
Sbjct: 1081 LGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENA 1140
Query: 1141 VTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNP 1200
VTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNP
Sbjct: 1141 VTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNP 1200
Query: 1201 RDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRT 1260
RDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRT
Sbjct: 1201 RDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRT 1260
Query: 1261 AEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEV 1320
AEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEV
Sbjct: 1261 AEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEV 1320
Query: 1321 ARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGS 1380
ARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGS
Sbjct: 1321 ARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGS 1380
Query: 1381 LSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSG 1440
LSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSG
Sbjct: 1381 LSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSG 1440
Query: 1441 TEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREG 1500
TEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREG
Sbjct: 1441 TEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREG 1500
Query: 1501 QNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQD 1560
QNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQD
Sbjct: 1501 QNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQD 1560
Query: 1561 ELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVT 1620
ELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVT
Sbjct: 1561 ELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVT 1620
Query: 1621 AEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLE 1680
AEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLE
Sbjct: 1621 AEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLE 1680
Query: 1681 QEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDR 1740
QEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDR
Sbjct: 1681 QEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDR 1740
Query: 1741 LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE 1800
LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE
Sbjct: 1741 LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE 1800
Query: 1801 HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ 1860
HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ
Sbjct: 1801 HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ 1860
Query: 1861 GNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1897
GNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP
Sbjct: 1861 GNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1897
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 3658 bits (9485), Expect = 0.0
Identities = 1847/1857 (99%), Positives = 1849/1857 (99%), Gaps = 8/1857 (0%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
Query: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Query: 821 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880
VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG EELISFKAERRDSRDVDE
Sbjct: 788 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG--------EELISFKAERRDSRDVDE 839
Query: 881 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940
EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 840 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
Query: 941 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000
DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 900 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
Query: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060
STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 960 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
Query: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120
HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
Query: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180
GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
Query: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240
KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
Query: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300
CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
Query: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360
CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
Query: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420
ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
Query: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480
TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
Query: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540
PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
Query: 1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1600
TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT
Sbjct: 1500 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1559
Query: 1601 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1660
MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE
Sbjct: 1560 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1619
Query: 1661 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1720
LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG
Sbjct: 1620 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1679
Query: 1721 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1780
QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT
Sbjct: 1680 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1739
Query: 1781 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1840
EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG
Sbjct: 1740 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1799
Query: 1841 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1897
NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP
Sbjct: 1800 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1856
Score = 375 bits (962), Expect = e-103
Identities = 233/614 (37%), Positives = 321/614 (52%), Gaps = 62/614 (10%)
Query: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI--- 320
SV F + T A+R GN+ L G I T ++ L LH A++ GHV++
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 321 ---SEILLD---------------------------HGAPIQAKTKNGLSPIHMAAQGDH 350
EI+L+ +GA + A+++ G +P++MAAQ +H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-------------------------- 384
L+ V+ LL+ A + T D TPL VA GH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183
Query: 385 ---RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
R A VLL P+ + GFTPLHIA ++ V +LLL GAS++ ++G+TPL
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
H+AS G++ +V+ LL RGA TPLH AAR GH +++ LL + A + AK K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
+ +P+H AA+ H + V+LLL+ +A + T TPLH+AA GH LL+K A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
GFTPLH+A K VRV ELLL+ A +A ++GLTPLHVA +L IVK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681
L RG SP+ TPLH+AA+ EVA+ LLQ NA++ TPLH AA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
MV LLL AN NL +G TPLH+ A+EGHV L++ T+ G+TPLHVA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
+ YG +++ + LL+ A NA K G +PLH A + DIV LLL G SP+ + +G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 802 TPLAIAKRLGYISV 815
TPL IA + + V
Sbjct: 604 TPLHIAAKQNQVEV 617
Score = 202 bits (513), Expect = 3e-51
Identities = 122/353 (34%), Positives = 183/353 (51%), Gaps = 29/353 (8%)
Query: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
V + D T AAR G+ + L N + N G LH+A++EGHV+ V+ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
L KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A N+L
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 616 DIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHIAAKQN 646
++VK LL G + + +G+TP LHIAA+ +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706
A LLQ + + S G TPLH+AA + + LLL++ A+ N ++G+TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
+ ++ G+V + +L+ G ++ T+ TPLH A+ G++++ + LL H A + AKTK
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
G SP+H AAQ H D V LLL+ A ++++ D TPL +A G+ V VL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 197 bits (500), Expect = 1e-49
Identities = 114/329 (34%), Positives = 176/329 (53%), Gaps = 4/329 (1%)
Query: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
+N+++ K D T AAR G+ + L N + N G LH+A++EGHV+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
V+ LL KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LP 208
N+L++VK LL G + + +G+TPL +A +Q V L+ YG +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
LH+AA+ A+LL N ++ +K+G TPLH+ A ++ VA +L+ G V+ T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
+ G TPLH+AS GN+ +V+ LL A + KTK +PLH AA+ GH I +LL +G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
A + +G +P+ +A + ++ +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 3644 bits (9449), Expect = 0.0
Identities = 1847/1882 (98%), Positives = 1849/1882 (98%), Gaps = 33/1882 (1%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
Query: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Query: 821 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880
VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG EELISFKAERRDSRDVDE
Sbjct: 788 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG--------EELISFKAERRDSRDVDE 839
Query: 881 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940
EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 840 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
Query: 941 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000
DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 900 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
Query: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060
STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 960 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
Query: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120
HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
Query: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180
GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
Query: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240
KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
Query: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300
CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
Query: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360
CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
Query: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420
ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
Query: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480
TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
Query: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540
PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
Query: 1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1600
TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT
Sbjct: 1500 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1559
Query: 1601 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1660
MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE
Sbjct: 1560 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1619
Query: 1661 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1720
LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG
Sbjct: 1620 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1679
Query: 1721 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1780
QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT
Sbjct: 1680 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1739
Query: 1781 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1840
EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG
Sbjct: 1740 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1799
Query: 1841 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE----------- 1889
NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE
Sbjct: 1800 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPS 1859
Query: 1890 --------------DHTSTPNP 1897
DHTSTPNP
Sbjct: 1860 ELEVDIDYFMKHSKDHTSTPNP 1881
Score = 375 bits (962), Expect = e-103
Identities = 233/614 (37%), Positives = 321/614 (52%), Gaps = 62/614 (10%)
Query: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI--- 320
SV F + T A+R GN+ L G I T ++ L LH A++ GHV++
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 321 ---SEILLD---------------------------HGAPIQAKTKNGLSPIHMAAQGDH 350
EI+L+ +GA + A+++ G +P++MAAQ +H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-------------------------- 384
L+ V+ LL+ A + T D TPL VA GH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183
Query: 385 ---RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
R A VLL P+ + GFTPLHIA ++ V +LLL GAS++ ++G+TPL
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
H+AS G++ +V+ LL RGA TPLH AAR GH +++ LL + A + AK K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
+ +P+H AA+ H + V+LLL+ +A + T TPLH+AA GH LL+K A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
GFTPLH+A K VRV ELLL+ A +A ++GLTPLHVA +L IVK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681
L RG SP+ TPLH+AA+ EVA+ LLQ NA++ TPLH AA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
MV LLL AN NL +G TPLH+ A+EGHV L++ T+ G+TPLHVA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
+ YG +++ + LL+ A NA K G +PLH A + DIV LLL G SP+ + +G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 802 TPLAIAKRLGYISV 815
TPL IA + + V
Sbjct: 604 TPLHIAAKQNQVEV 617
Score = 202 bits (513), Expect = 3e-51
Identities = 122/353 (34%), Positives = 183/353 (51%), Gaps = 29/353 (8%)
Query: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
V + D T AAR G+ + L N + N G LH+A++EGHV+ V+ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
L KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A N+L
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 616 DIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHIAAKQN 646
++VK LL G + + +G+TP LHIAA+ +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706
A LLQ + + S G TPLH+AA + + LLL++ A+ N ++G+TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
+ ++ G+V + +L+ G ++ T+ TPLH A+ G++++ + LL H A + AKTK
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
G SP+H AAQ H D V LLL+ A ++++ D TPL +A G+ V VL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 197 bits (500), Expect = 1e-49
Identities = 114/329 (34%), Positives = 176/329 (53%), Gaps = 4/329 (1%)
Query: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
+N+++ K D T AAR G+ + L N + N G LH+A++EGHV+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
V+ LL KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LP 208
N+L++VK LL G + + +G+TPL +A +Q V L+ YG +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
LH+AA+ A+LL N ++ +K+G TPLH+ A ++ VA +L+ G V+ T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
+ G TPLH+AS GN+ +V+ LL A + KTK +PLH AA+ GH I +LL +G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
A + +G +P+ +A + ++ +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 3639 bits (9437), Expect = 0.0
Identities = 1839/1849 (99%), Positives = 1841/1849 (99%), Gaps = 8/1849 (0%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
Query: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Query: 821 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880
VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG EELISFKAERRDSRDVDE
Sbjct: 788 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG--------EELISFKAERRDSRDVDE 839
Query: 881 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940
EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 840 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
Query: 941 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000
DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 900 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
Query: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060
STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 960 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
Query: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120
HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
Query: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180
GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
Query: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240
KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
Query: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300
CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
Query: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360
CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
Query: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420
ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
Query: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480
TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
Query: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540
PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
Query: 1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1600
TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT
Sbjct: 1500 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1559
Query: 1601 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1660
MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE
Sbjct: 1560 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1619
Query: 1661 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1720
LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG
Sbjct: 1620 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1679
Query: 1721 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1780
QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT
Sbjct: 1680 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1739
Query: 1781 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1840
EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG
Sbjct: 1740 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1799
Query: 1841 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE 1889
NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE
Sbjct: 1800 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE 1848
Score = 375 bits (962), Expect = e-103
Identities = 233/614 (37%), Positives = 321/614 (52%), Gaps = 62/614 (10%)
Query: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI--- 320
SV F + T A+R GN+ L G I T ++ L LH A++ GHV++
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 321 ---SEILLD---------------------------HGAPIQAKTKNGLSPIHMAAQGDH 350
EI+L+ +GA + A+++ G +P++MAAQ +H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-------------------------- 384
L+ V+ LL+ A + T D TPL VA GH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183
Query: 385 ---RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
R A VLL P+ + GFTPLHIA ++ V +LLL GAS++ ++G+TPL
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
H+AS G++ +V+ LL RGA TPLH AAR GH +++ LL + A + AK K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
+ +P+H AA+ H + V+LLL+ +A + T TPLH+AA GH LL+K A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
GFTPLH+A K VRV ELLL+ A +A ++GLTPLHVA +L IVK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681
L RG SP+ TPLH+AA+ EVA+ LLQ NA++ TPLH AA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
MV LLL AN NL +G TPLH+ A+EGHV L++ T+ G+TPLHVA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
+ YG +++ + LL+ A NA K G +PLH A + DIV LLL G SP+ + +G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 802 TPLAIAKRLGYISV 815
TPL IA + + V
Sbjct: 604 TPLHIAAKQNQVEV 617
Score = 202 bits (513), Expect = 3e-51
Identities = 122/353 (34%), Positives = 183/353 (51%), Gaps = 29/353 (8%)
Query: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
V + D T AAR G+ + L N + N G LH+A++EGHV+ V+ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
L KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A N+L
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 616 DIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHIAAKQN 646
++VK LL G + + +G+TP LHIAA+ +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706
A LLQ + + S G TPLH+AA + + LLL++ A+ N ++G+TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
+ ++ G+V + +L+ G ++ T+ TPLH A+ G++++ + LL H A + AKTK
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
G SP+H AAQ H D V LLL+ A ++++ D TPL +A G+ V VL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 197 bits (500), Expect = 1e-49
Identities = 114/329 (34%), Positives = 176/329 (53%), Gaps = 4/329 (1%)
Query: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
+N+++ K D T AAR G+ + L N + N G LH+A++EGHV+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
V+ LL KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LP 208
N+L++VK LL G + + +G+TPL +A +Q V L+ YG +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
LH+AA+ A+LL N ++ +K+G TPLH+ A ++ VA +L+ G V+ T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
+ G TPLH+AS GN+ +V+ LL A + KTK +PLH AA+ GH I +LL +G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
A + +G +P+ +A + ++ +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 2980 bits (7725), Expect = 0.0
Identities = 1504/1515 (99%), Positives = 1507/1515 (99%), Gaps = 8/1515 (0%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
Query: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
Query: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
Query: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Query: 821 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880
VVTDETSFVLVSDKHRMSFPETVDEILDVSEDE GEELISFKAERRDSRDVDE
Sbjct: 788 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDE--------GEELISFKAERRDSRDVDE 839
Query: 881 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940
EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 840 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
Query: 941 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000
DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 900 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
Query: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060
STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 960 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
Query: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120
HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
Query: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180
GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
Query: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240
KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
Query: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300
CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
Query: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360
CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
Query: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420
ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
Query: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480
TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
Query: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540
PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
Query: 1541 TDRDYSLSPSQMNGY 1555
TDRDYSLSPSQMNG+
Sbjct: 1500 TDRDYSLSPSQMNGH 1514
Score = 375 bits (962), Expect = e-103
Identities = 233/614 (37%), Positives = 321/614 (52%), Gaps = 62/614 (10%)
Query: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI--- 320
SV F + T A+R GN+ L G I T ++ L LH A++ GHV++
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 321 ---SEILLD---------------------------HGAPIQAKTKNGLSPIHMAAQGDH 350
EI+L+ +GA + A+++ G +P++MAAQ +H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-------------------------- 384
L+ V+ LL+ A + T D TPL VA GH
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183
Query: 385 ---RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
R A VLL P+ + GFTPLHIA ++ V +LLL GAS++ ++G+TPL
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Query: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
H+AS G++ +V+ LL RGA TPLH AAR GH +++ LL + A + AK K
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
+ +P+H AA+ H + V+LLL+ +A + T TPLH+AA GH LL+K A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
GFTPLH+A K VRV ELLL+ A +A ++GLTPLHVA +L IVK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681
L RG SP+ TPLH+AA+ EVA+ LLQ NA++ TPLH AA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
MV LLL AN NL +G TPLH+ A+EGHV L++ T+ G+TPLHVA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
+ YG +++ + LL+ A NA K G +PLH A + DIV LLL G SP+ + +G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 802 TPLAIAKRLGYISV 815
TPL IA + + V
Sbjct: 604 TPLHIAAKQNQVEV 617
Score = 358 bits (919), Expect = 3e-98
Identities = 190/237 (80%), Positives = 193/237 (81%), Gaps = 30/237 (12%)
Query: 1691 LPGSKRQD-----DATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWD 1745
L GS RQ D +D S ++GHQRGQARITHSPTVSQVTERSQDRLQDWD
Sbjct: 1483 LEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGHQRGQARITHSPTVSQVTERSQDRLQDWD 1542
Query: 1746 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1805
ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE
Sbjct: 1543 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1602
Query: 1806 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1865
QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT
Sbjct: 1603 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1662
Query: 1866 KKIIRKVVRQIDLSSADAAQEHEE-------------------------DHTSTPNP 1897
KKIIRKVVRQIDLSSADAAQEHEE DHTSTPNP
Sbjct: 1663 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 1719
Score = 202 bits (513), Expect = 3e-51
Identities = 122/353 (34%), Positives = 183/353 (51%), Gaps = 29/353 (8%)
Query: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
V + D T AAR G+ + L N + N G LH+A++EGHV+ V+ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
L KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A N+L
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 616 DIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHIAAKQN 646
++VK LL G + + +G+TP LHIAA+ +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706
A LLQ + + S G TPLH+AA + + LLL++ A+ N ++G+TPLH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
+ ++ G+V + +L+ G ++ T+ TPLH A+ G++++ + LL H A + AKTK
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
G SP+H AAQ H D V LLL+ A ++++ D TPL +A G+ V VL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 197 bits (500), Expect = 1e-49
Identities = 114/329 (34%), Positives = 176/329 (53%), Gaps = 4/329 (1%)
Query: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
+N+++ K D T AAR G+ + L N + N G LH+A++EGHV+
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
V+ LL KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LP 208
N+L++VK LL G + + +G+TPL +A +Q V L+ YG +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
LH+AA+ A+LL N ++ +K+G TPLH+ A ++ VA +L+ G V+ T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
+ G TPLH+AS GN+ +V+ LL A + KTK +PLH AA+ GH I +LL +G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
A + +G +P+ +A + ++ +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 1784 bits (4620), Expect = 0.0
Identities = 913/1484 (61%), Positives = 1127/1484 (75%), Gaps = 52/1484 (3%)
Query: 1 MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK 60
MA AA QLKK +D+E A +E+ E RK R RSRDRKKK+DA S+LRAAR+G+L+K
Sbjct: 1 MAHAASQLKKNRDLEINA----EEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEK 56
Query: 61 ALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAAL 120
ALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +E ++ TKKGNTALHIA+L
Sbjct: 57 ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASL 116
Query: 121 AGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
AGQ EVV+ LV GANVNAQSQ GFTPLYMAAQENHLEVVKFLL+NGA+Q++ATEDGFTP
Sbjct: 117 AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Query: 181 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240
LAVALQQGH+ VV+ L+ TKGKVRLPALHIAAR DDT+ AA+LLQND N DV SK+GF
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGF 236
Query: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
TPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS+RGN MV+LLLDRGA+I+
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
KT+D LTPLHC AR+GH ++ E+LLD API +KTKNGLSP+HMA QGDHL+CV+LLLQ+
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Query: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
+ +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++ALNGFTPLHIACKKN ++VM
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
ELLLK GASI AVTESGLTP+HVA+FMGH+ IV L+ GASPN +NV+ ET LHMAAR+
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
G EV +YL+Q+ A+V AKAKDDQTPLH +AR+G ++V+ LL+ A+PN ATT+G+TPL
Sbjct: 477 GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
H++AREGH + LL+ AS + TKKGFTPLHVAAKYGK+ VA LLL++ A P+AAGK
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
Query: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
+GLTPLHVA H++N + LLL +G SPH+ A NGYTPLHIAAK+NQ+++A +LL+YG
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Query: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
ANA + QG+ +HLAAQEGH +MV+LLL + AN NL NKSGLTPLHL AQE V VA+VL
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Query: 721 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780
+ G VDA T+MGYTPLHV HYGNIK+V FLLQH A VNAKTK GY+PLHQAAQQGHT
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
Query: 781 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET-SFVLVSDKHRMSF 839
I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK+VT+ET + V++KH+M+
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNV 836
Query: 840 PETVDEILDVSEDE---GTAHITIMGEELISFKAERRDSRDVDEEK-------------- 882
PET++E+LD+S+DE A + E IS E D+ D +K
Sbjct: 837 PETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDS 896
Query: 883 ----------------ELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYD 926
L F + + R + E +V E+ ++E+D
Sbjct: 897 LPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFD 956
Query: 927 EDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAA 986
DSL S A +T DN++ V+SP+H+GFLVSFMVDARGGSMRGSRH+G+R++IPPR C A
Sbjct: 957 SDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTA 1016
Query: 987 PTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE 1046
PTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQFL PVIVEIPHF S +RE
Sbjct: 1017 PTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERE 1076
Query: 1047 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1106
L+VLRSENG WKEH+ L ++LNGMDEEL S EEL KKR+CRIIT DFP YF +
Sbjct: 1077 LIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAV 1136
Query: 1107 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1166
+SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+++ LQAQPVPDE+V K+LGN+
Sbjct: 1137 VSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNK 1196
Query: 1167 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTT-SLRLLCSVIGGTDQAQ 1225
ATFSPIVTVEPRRRKFH+PI + IP+PP + + +GDTT +LRLLCS+ GGT AQ
Sbjct: 1197 ATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQ 1256
Query: 1226 WEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVI 1285
WEDITGTT L + +C +FTTNVSARFWL+DC + E V AT LY+EL VPYMAKFV+
Sbjct: 1257 WEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVV 1316
Query: 1286 FAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPV 1345
FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+DIEVLEG ++ + GNL P+
Sbjct: 1317 FAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPL 1376
Query: 1346 KKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYED-TQHILCHLNITM 1404
K QQ F+F SF+ENRL +K+RD+S+EP G LSFL++ + Q +C+LNIT+
Sbjct: 1377 TKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITL 1436
Query: 1405 PPCAKGSGAE--------DRRRTPTPLAL--RYSILSESTPGSL 1438
P K + ++ DRR++ LAL RYS L+E PG +
Sbjct: 1437 PAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE--PGMI 1478
Score = 107 bits (268), Expect = 8e-23
Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)
Query: 1406 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1460
P A D++ PL + S G S E+ +++MA++++HLGLSW
Sbjct: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
Query: 1461 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1520
ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+NA + L + L I+R +I
Sbjct: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
Query: 1521 VNMLEGSGRQSRNLKPDRRHTDRD 1544
V +LEG N+ R D +
Sbjct: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 1769 bits (4583), Expect = 0.0
Identities = 919/1608 (57%), Positives = 1172/1608 (72%), Gaps = 75/1608 (4%)
Query: 20 QEQKEKEESNRKRRNRSRDRK--KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQN 77
++ +K +S K S+ RK KK+D+ SFLRAAR+GNLDK +++L+ G+DINTCNQN
Sbjct: 4 EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63
Query: 78 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
GLN LHLA+KEGHV +V ELL + +++ TKKGNTALHIA+LAGQ EVV+ LV GAN+
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 138 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197
NAQSQ GFTPLYMAAQENH++VVK+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK--------TGFTPLHIAAHY 249
TKGKVRLPALHIAAR DDT++AA+LLQND N DV SK +GFTPLHIAAHY
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
N+NVA LLLNRGA+V+FT +NGITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Query: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369
HCAAR+GH ++ E+LL+ GAP+ A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TL
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363
Query: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
D+LT LHVAAHCGH+RV K+LLDK A PN+RALNGFTPLHIACKKN ++VMELL+K GAS
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
I A+TESGLTP+HVA+FMGHL IV LLQ GASP+V+N++ ET LHMAARAG EV + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
L+N A V+A+A+++QTPLH A+R+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Query: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
+ LLE A+ + TKKGFTPLHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 610 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 669
H++N + LLL +G SPH+ A NGYTPLHIAAK+NQ+++A +LL YG N + QGV
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
TPLHLA+QEGH +MV LLL K AN ++ KSGLT LHL AQE V VAD+L KHG DA
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
T++GYTPL VA HYGN+K+V FLL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEIL 847
GA PN +++G T LAIAKRLGYISV D LKVVT+E T+ +++KH+++ PET+ E+L
Sbjct: 784 GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 843
Query: 848 DVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLD-------------------FV 888
DVS++EG +T G E + + + D + LD F
Sbjct: 844 DVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFS 903
Query: 889 PKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVAS 948
+ + R M ++VVI S + +KE + +S S TE DN++ +S
Sbjct: 904 SDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSS 962
Query: 949 PVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAE 1008
P+H+GFLVSFMVDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E
Sbjct: 963 PIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVE 1022
Query: 1009 EEGLASRIIALGPTGAQ---------------------------------FLSPVIVEIP 1035
EGLASR+I +GP+GAQ FL PVIVEIP
Sbjct: 1023 GEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIP 1082
Query: 1036 HFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI 1095
HFA+ +RELVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRI
Sbjct: 1083 HFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRI 1142
Query: 1096 ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVP 1155
IT DFP YF ++SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+
Sbjct: 1143 ITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMH 1202
Query: 1156 DELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLC 1215
ELV K+LGN+ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLC
Sbjct: 1203 SELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLC 1262
Query: 1216 SVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT 1275
S+ GGT AQWEDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+
Sbjct: 1263 SITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREII 1322
Query: 1276 AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLF 1335
VPYMAKFV+FAK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++
Sbjct: 1323 CVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIY 1382
Query: 1336 AELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH 1395
+ GNLVP+ K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H
Sbjct: 1383 VDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVH 1442
Query: 1396 -ILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEH 1454
+C+LNIT+P K S ++ + + SE P E+ E ++A I++H
Sbjct: 1443 QAICNLNITLPIYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADH 1494
Query: 1455 LGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQS 1514
LG SW ELAREL F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L
Sbjct: 1495 LGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTK 1554
Query: 1515 IDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL 1562
I+R +IV+++E + + + + + + +++ G+S LQ+EL
Sbjct: 1555 INRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 1601
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/48 (39%), Positives = 30/48 (62%)
Query: 1839 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1886
+G++ IP E VTEE++ DE G+ V KK+ RK++R+ S +E
Sbjct: 1785 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1832
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 1753 bits (4540), Expect = 0.0
Identities = 912/1597 (57%), Positives = 1161/1597 (72%), Gaps = 85/1597 (5%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
+K+D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
Query: 221 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
Query: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
Query: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
Query: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
Query: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
Query: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Query: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
Query: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Query: 813 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKA 870
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG +T G E + +
Sbjct: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
Query: 871 ERRDSRDVDEEKELLD-------------------FVPKLDQVVESPAIPRIPCAMPETV 911
+ D + LD F + + R M ++V
Sbjct: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
Query: 912 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 959
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
Query: 960 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 1019
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
Query: 1020 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1046
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
Query: 1047 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1106
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
Query: 1107 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1166
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
Query: 1167 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1226
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
Query: 1227 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1286
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
Query: 1287 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1346
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
Query: 1347 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1405
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
Query: 1406 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1465
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
Query: 1466 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1525
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
Query: 1526 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL 1562
+ + + + + + +++ G+S LQ+EL
Sbjct: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 1592
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/48 (39%), Positives = 30/48 (62%)
Query: 1839 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1886
+G++ IP E VTEE++ DE G+ V KK+ RK++R+ S +E
Sbjct: 1776 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1823
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 1690 bits (4377), Expect = 0.0
Identities = 877/1519 (57%), Positives = 1112/1519 (73%), Gaps = 73/1519 (4%)
Query: 20 QEQKEKEESNRKRRNRSRDRK--KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQN 77
++ +K +S K S+ RK KK+D+ SFLRAAR+GNLDK +++L+ G+DINTCNQN
Sbjct: 4 EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63
Query: 78 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
GLN LHLA+KEGHV +V ELL + +++ TKKGNTALHIA+LAGQ EVV+ LV GAN+
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 138 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197
NAQSQ GFTPLYMAAQENH++VVK+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK--------TGFTPLHIAAHY 249
TKGKVRLPALHIAAR DDT++AA+LLQND N DV SK +GFTPLHIAAHY
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
N+NVA LLLNRGA+V+FT +NGITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
Query: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369
HCAAR+GH ++ E+LL+ GAP+ A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TL
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363
Query: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
D+LT LHVAAHCGH+RV K+LLDK A PN+RALNGFTPLHIACKKN ++VMELL+K GAS
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
I A+TESGLTP+HVA+FMGHL IV LLQ GASP+V+N++ ET LHMAARAG EV + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
L+N A V+A+A+++QTPLH A+R+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Query: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
+ LLE A+ + TKKGFTPLHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 610 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 669
H++N + LLL +G SPH+ A NGYTPLHIAAK+NQ+++A +LL YG N + QGV
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
TPLHLA+QEGH +MV LLL K AN ++ KSGLT LHL AQE V VAD+L KHG DA
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
T++GYTPL VA HYGN+K+V FLL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEIL 847
GA PN +++G T LAIAKRLGYISV D LKVVT+E T+ +++KH+++ PET+ E+L
Sbjct: 784 GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 843
Query: 848 DVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLD-------------------FV 888
DVS++EG +T G E + + + D + LD F
Sbjct: 844 DVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFS 903
Query: 889 PKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVAS 948
+ + R M ++VVI S + +KE + +S S TE DN++ +S
Sbjct: 904 SDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSS 962
Query: 949 PVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAE 1008
P+H+GFLVSFMVDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E
Sbjct: 963 PIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVE 1022
Query: 1009 EEGLASRIIALGPTGAQ---------------------------------FLSPVIVEIP 1035
EGLASR+I +GP+GAQ FL PVIVEIP
Sbjct: 1023 GEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIP 1082
Query: 1036 HFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI 1095
HFA+ +RELVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRI
Sbjct: 1083 HFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRI 1142
Query: 1096 ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVP 1155
IT DFP YF ++SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+
Sbjct: 1143 ITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMH 1202
Query: 1156 DELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLC 1215
ELV K+LGN+ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLC
Sbjct: 1203 SELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLC 1262
Query: 1216 SVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT 1275
S+ GGT AQWEDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+
Sbjct: 1263 SITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREII 1322
Query: 1276 AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLF 1335
VPYMAKFV+FAK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++
Sbjct: 1323 CVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIY 1382
Query: 1336 AELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH 1395
+ GNLVP+ K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H
Sbjct: 1383 VDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVH 1442
Query: 1396 -ILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEH 1454
+C+LNIT+P K S ++ + + + +ES TE + +K +++E
Sbjct: 1443 QAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETES-------TETSVLKSHLVNEV 1495
Query: 1455 LGLSWAELARELQFSVEDI 1473
L+ +L E+ +D+
Sbjct: 1496 PVLASPDLLSEVSEMKQDL 1514
Score = 95.5 bits (236), Expect = 4e-19
Identities = 49/121 (40%), Positives = 79/121 (65%), Gaps = 1/121 (0%)
Query: 1442 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1501
E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL W+ R+G+
Sbjct: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
Query: 1502 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1561
+A NL L I+R +IV+++E + + + + + + +++ G+S LQ+E
Sbjct: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
Query: 1562 L 1562
L
Sbjct: 3686 L 3686
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/48 (39%), Positives = 30/48 (62%)
Query: 1839 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1886
+G++ IP E VTEE++ DE G+ V KK+ RK++R+ S +E
Sbjct: 3870 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 3917
>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
Length = 1001
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 907 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 965
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
Query: 966 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 1025
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
Query: 1026 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1085
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
Query: 1086 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1145
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
Query: 1146 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1205
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
Query: 1206 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1264
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
Query: 1265 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1324
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
Query: 1325 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1384
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
Query: 1385 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1441
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
Query: 1442 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1501
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
Query: 1502 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1561
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
Query: 1562 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1621
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
Query: 1622 EDSSLECSKAEDS 1634
ED+SLE SK EDS
Sbjct: 788 EDASLEDSKLEDS 800
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 332 bits (852), Expect = 2e-90
Identities = 261/832 (31%), Positives = 380/832 (45%), Gaps = 99/832 (11%)
Query: 70 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 129
++N ++ G LH A+ GH +MV LL + + KK A+H AA G EVV+
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 130 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 189
LV++GA V + +K +TPL+ AA + VVK+LL+ G + N G TPL VA G
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
Query: 190 ENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLH 244
+ VV LI+ G K + LH AA + LL N + ++ SK G TPLH
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
Query: 245 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV---------------- 288
+ A + + +Q ++ GA ++ +NG TPLHIA+R G+ +++
Sbjct: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
Query: 289 -----------------RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
R LL G I+T T LH AA G++ +LL+ GA
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
Query: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-RVAKVL 390
K K G SP+H AA + C+ L+ A ++D+ TPLH AA + + L
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 391 LDKGAKPNSRALNGF--------------------------------------------- 405
L A P R G+
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
+PLH+A H + +E+L+++ +D SG TPL +A+F GH+ V L+ +GAS V
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 466 SN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKL 521
+ + TP+H AA GH+E + L+ N NA D QTPL + GHT+ V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 581
LL AN + G T LH A GH E V ALL+ A +G TP+H++A G
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Query: 582 VRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637
+ V LL+ DA+P A +G T LH A ++ + V+LLL + + N ++
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFS 790
Query: 638 PLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
PLH A + A L+ G++ NA +G TPLH AA H E + LLLS A N
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLL 754
+ +G TPL + A+ G ++L+ + T LH+A G+ +L
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910
Query: 755 QHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
+ D +NA +PLH AA+ G T +V LL GAS V +G TP
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 327 bits (839), Expect = 5e-89
Identities = 249/814 (30%), Positives = 388/814 (47%), Gaps = 33/814 (4%)
Query: 36 SRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 95
+R K + T RA S + + L++ D+N ++N LH+A+ VK
Sbjct: 65 ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
Query: 96 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 155
L+ + + + G TALH AA +G E+V+ L++ GAN+NA +K ++ AA
Sbjct: 125 ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMG 184
Query: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALH 211
H+EVVK L+ +GA + +TPL A G +VV +L++ G LH
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
Query: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQ 270
+A N L+ + ++ GFTPLH AA +LL+ GA VN +
Sbjct: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
Query: 271 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330
+G TPLH+ + G + ++ GA I+ + K+ TPLH AAR GH + L+ GA
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 331 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390
+ +G+ P+H+AA DC R LL +ID T LH AA G+ +L
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Query: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-H 449
L+ GA N + G +PLH A + + + L+ +GAS++ + E G TPLH A+
Sbjct: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
Query: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAK 501
++ LL+ A+P + + + +H +A GH +E +L + + +
Sbjct: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSD 544
Query: 502 DDQ----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 557
D +PLH AA GH +++L+++ + ++ ++G TPL +AA +GHVE V L+
Sbjct: 545 SDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
Query: 558 KEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVH 611
+ AS + + K+ TP+H AA G LL+ NA NG TPL ++V
Sbjct: 605 QGASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL 662
Query: 612 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 671
+ + D V LL +G + + G T LH A E +LLQ+G +G TP
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
Query: 672 LHLAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
+HL+A GH ++ LL S AN + G T LH GH ++L++ V
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF- 781
Query: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
T ++PLH A N + L+ + VNA G +PLH AA H + + L
Sbjct: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
Query: 786 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
LL + A N V S G TPL +A G + ++L
Sbjct: 842 LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 308 bits (790), Expect = 2e-83
Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)
Query: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
S ++A +G+ D+ + D+N + LH A+ G +++ L+ +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 167
K T LH A + +E V+ L+ + A+VNA+ + TPL++AA ++ + L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 223
+N NV+ G T L A GH +V L++ G K A+H AA
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
+L+ + K +TPLH AA ++V + LL+ G +N G TPLH+A G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 284 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 342
++V L+D GA + K + TPLH AA + H + E+L+ +GA + K+K+G +P+
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402
HM A + ++Q A ID + TPLH+AA GH + L+ GA R +
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
Query: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
+G PLH+A LL +G ID + G T LH A+ G+L + LL GA
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
Query: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 521
N + +PLH AA + + L+ + A VN + TPLH AA ++
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
Query: 522 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 569
LL N+ANP + G+ +H +A GH ET L +L + + ++ +
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
+PLH+AA +G + E+L++ + +G TPL +A +++ V +L+ +G S
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 630 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 685
+ TP+H AA E R L+ NA +Q G TPL L+ GH + V
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 745
LL+K AN + +K G T LH A GH D L++HG G TP+H+++ G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 746 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 788
+I ++ LLQ A ++A GY+ LH A GH V LLL+
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
Score = 290 bits (741), Expect = 1e-77
Identities = 222/753 (29%), Positives = 339/753 (45%), Gaps = 80/753 (10%)
Query: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
A G + VR L+ +VN Q + TPL+ AA E+++ L+ +GA N
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
TPL H A + VLL++ + + K
Sbjct: 75 LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
Query: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
TPLHIAA + + A+ L+ ++VN + + G T LH A+ G+ MV+LLL RGA
Sbjct: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
Query: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
I K + +H AA GH+ + ++L+ HGA + K K +P+H AA + V+ L
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
Query: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 416
L ++++ TPLHVA + G V L+D GA N + GFTPLH A H
Sbjct: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
Query: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
+ELL+ GA ++ ++ G TPLH+ + G + ++Q GA + + TPLH+
Sbjct: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
Query: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
AAR GH + L+ + A + PLH AA G ++ + LL + + + G
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
Query: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
T LH AA G++E + LL A K G +PLH AA + L+ A N
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 597 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 652
+ G TPLH A + ++ LL +P GY +H +A +++
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
Query: 653 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703
S L++ G+ +++++ ++PLHLAA GH + + +L+ + ++ N SG T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 704 PLHLVAQEGHVPVADVLIKHGV-------------------------------------M 726
PL L A +GHV DVLI G
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
Query: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
VD G TPL ++ G+ V LL A+V+AK K G + LH+ A GH + V L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 787 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
L++GA S G TP+ ++ G+I V L
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Score = 273 bits (699), Expect = 9e-73
Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)
Query: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267
P+L A N D L+ + + TPLH AA+ + + +LL+ GA VN
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
+TPLH A + V++LL A + + K+ TPLH AA N V+ +E L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
+ + + G + +H AA H + V+LLL A I+ +H AA+ GH V
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
Query: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
K+L+ GA+ + +TPLH A + V++ LL G ++ G TPLHVA +
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 506
G +V L+ GA N N K TPLH AA + H + + L+ N A VN K+KD +TP
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
LH A G + + ++++ A + G+TPLHIAAR GH + L+ A A
Sbjct: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
Query: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
G PLH+AA G LL + G T LH A NL+ + LLL G
Sbjct: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
Query: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 685
+ G +PLH AA + +L+ G S N +G TPLH AA + + +
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
Query: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 732
LL AN + +K G +H A GH P+ DVL++ ++ D+ R
Sbjct: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
Query: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792
+PLH+A+++G+ + ++ L+Q D++ + G +PL AA +GH + V +L+ GAS
Sbjct: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
Score = 259 bits (662), Expect = 2e-68
Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)
Query: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
L+ + VNF TPLH A+ G+ ++ LL+ GA++ K LTPLH A +
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377
++LL H A + A+ KN +P+H+AA + C L+ + ++ T LH
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437
AA GH + K+LL +GA N+ +H A H+ V++LL+ GA + +
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497
TPLH A+ G + +VK LL G N N TPLH+A G V L+ A VN
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 498 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
K + TPLH AA H + ++LL+ N A+ N+ + G TPLH+ A G ++
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
Query: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616
+ A C K G TPLH+AA+YG + L+ A G +G+ PLH+A D
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
+ LL G +P G T LH AA +E LL G N + G +PLH AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 735
+ + + L+ A+ N ++ G TPLH A + + L+++ + GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 736 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 783
+H ++ YG+ ++ + + DV +T + SPLH AA GH +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
Query: 784 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 833
+L+++ + +S G TPL +A G++ DVL ++ + +LV D
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
Score = 236 bits (601), Expect = 2e-61
Identities = 192/679 (28%), Positives = 298/679 (43%), Gaps = 65/679 (9%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
K D T A G ++ +++G I+ ++NG LH+A++ GH ++ L+
Sbjct: 302 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 361
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
G LH+AAL+G + R+L++ G +++ G T L+ AA +LE +
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARN 216
LL GA+ N + G +PL A + + L+ G + LH AA +
Sbjct: 422 NLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATS 481
Query: 217 D-DTRTAAVLLQNDPNPDVLSKTGF----------------------------------- 240
D D + LL+ND NP + K G+
Sbjct: 482 DTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDM 541
Query: 241 ----------TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290
+PLH+AA++ + ++L+ ++ +G TPL +A+ +G+V V +
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
Query: 291 LLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIHMAA 346
L+++GA I K + TP+H AA NGH +L+ + P + + NG +P+ ++
Sbjct: 602 LINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV 661
Query: 347 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 406
H DCV LL A +D T LH A GH LL GAK R G T
Sbjct: 662 LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 721
Query: 407 PLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
P+H++ H+ V+ LL++ AS+DA G T LH A + GH V+ LL++
Sbjct: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 781
Query: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAARIGHTNMVK 520
+PLH A + A+ L+ VNA +TPLH AA H ++
Sbjct: 782 QKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKY 579
LLL +NA N + G TPL +AA G TV L+ +++ + T LH+A
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 580 GKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
G A L+LE+ N TPLHVA + +V+ LL +G S + NGY
Sbjct: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
Query: 637 TPLHIAAKQNQVEVARSLL 655
TP A V +L+
Sbjct: 961 TPALACAPNKDVADCLALI 979
Score = 149 bits (377), Expect = 2e-35
Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)
Query: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
DQ L A G + V+ L+ + N TPLH AA G E + L+ A
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 563 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
K TPLH A ++LL+ A NA KN TPLH+A + + + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
P + + G T LH AA E+ + LL G + NA + +H AA GH E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
+V LL+S A +K TPLH A G + V L+ GV ++ G TPLHVA
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
Query: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 801
+ G +V L+ A VN K + G++PLH AA H + + LL+ NGA N S DG
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
Query: 802 TPLAIAKRLGYIS 814
TPL + G S
Sbjct: 308 TPLHMTALHGRFS 320
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 327 bits (837), Expect = 9e-89
Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
T RA S + + +++ D+N ++N LH+A+ VK ++ +
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
+ + G TALH AAL G E+V L+ GAN+NA +K L+ AA HL+VV L+ +
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 222
GA + G+TPL A G NVV HL+N G + ++ + ALHIA N
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
Query: 223 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
L+ N + + GFTPLH AA +LL+N GA VN ++G +PLH+ +
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
Query: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
G + L+ G +I+ KD TPLH AAR GH + L GA + + P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+H+AA H DC R LL EID T LH AA G+ K+L GA + +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 451
G TPLH A H +E L+ TGA+++ + G T LH A + +G+
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
Query: 452 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 491
++ LLQ A+P++ + + +H AA GH + + LL+
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 551
N + + ++PLH AA GH +++LL++ + ++ G T L +AA +GH E
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 552 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 605
V AL+ AS + +TK+ TPLH + G LLLE +P A G TP
Sbjct: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
Query: 606 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665
L +AV + ++D V LLL + + + G T LH E + LL+ S +
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
Query: 666 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
+G TPLH AA GHA ++ LL + + + G TPLH G+ +VL++
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Query: 723 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780
+TPLH A + +GN + + V+ + G +PL AA H
Sbjct: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
Query: 781 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 834
+ + LLL++ A N V + G T L +A G D+L V + + V DK
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
Score = 313 bits (801), Expect = 1e-84
Identities = 241/783 (30%), Positives = 353/783 (45%), Gaps = 83/783 (10%)
Query: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
AA G+LD + +G ++ ++ G LH A+ G + +V LL+ + ++ G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 170
NTALHIA GQD VV EL++YGANVN + GFTPL+ AA H + ++ L+ NGA+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 230
N+ ++DG +PL H+ A + + L+QN
Sbjct: 275 NIQSKDGKSPL-----------------------------HMTAVHGRFTRSQTLIQNGG 305
Query: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290
D + K G TPLH+AA Y + + L GA + + PLH+A+ + R
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 291 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 350
LL G +I+T K T LH AA G+V ++L GA K K G +P+H AA H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-------------------- 390
C+ L+ A +++ T LH AA R +L
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 391 --------LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLT--P 440
L A P+ R G+ +H A H + +ELLL+ S ++SG T P
Sbjct: 486 ATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSP 545
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
LH+A++ GH ++ LLQ ++ + K T L +AA GHTE + L+ A + K
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 501 K-DDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALL 556
+TPLH + GHT ++LLLE NP ++ G TPL +A GH++ V LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616
EKEA+ + G T LH G ++LLE++ G TPLH A +
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHAT 725
Query: 617 IVKLLLPRGGSPHSPAWN---GYTPLHIAA---KQNQVEVA---RSLLQYGGSANAESVQ 667
+ LL S + GYTPLH A +N +EV + ++ G+
Sbjct: 726 WLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP------ 779
Query: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGHVPVADVLIKHGV 725
TPLH A H +LLL + + + G TPL A HV +L++H
Sbjct: 780 -FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVT 784
V+A G T L +A+ G V L+ QAD+ K K +PLH A +GH
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898
Query: 785 LLL 787
L+L
Sbjct: 899 LIL 901
Score = 300 bits (768), Expect = 9e-81
Identities = 227/765 (29%), Positives = 350/765 (45%), Gaps = 42/765 (5%)
Query: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156
L+HK + T + T LH+AA G E++ L+ GA VNA+ TPL+ A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQ----QGHENVVAHLINYGTKGKVRLPALHI 212
E V+ L+++ A+ N ++ TPL VA + E ++ L + + ALH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
AA N +LL N + K LH AA+ +L+V LL+N GA V + G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
TPLH A+ G + +V+ LL+ G +I+ T LH A NG + L+D+GA +
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 333 AKTKNGLSPIHMAAQGDH-LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
NG +P+H AA H C+ LL+ A+++ + D +PLH+ A G ++ L+
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
Query: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451
G + + +G TPLH+A + H ++ L +GA + PLH+A+ H
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Query: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 511
+ LL G + + T LH AA G+ E K L + A + K K +TPLH AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
Query: 512 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE--GHVETVLA--------------- 554
H + ++ L+ AN N G T LH AA +T+L
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
Query: 555 -----------LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603
LL+ +A+ + K+G+ +H AA YG + ELLLER +G
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 604 T--PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
T PLH+A ++ + +++LL G T L +AA + E +L+ G S
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 662 NA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANG---NLGNKSGLTPLHLVAQEGHVPVA 717
++V TPLH + GH + LLL N ++ + G TPL L GH+
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
Query: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
+L++ VD +G T LH G+ + V+ LL+ + + K G +PLH AA +
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Query: 778 GHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKRLGYISVTDVL 819
GH ++ LL+ S + + G TPL A G + +VL
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Score = 262 bits (670), Expect = 2e-69
Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
+L+ + + L TPLH+AA + + +LL+ GA VN +TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 284 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 343
+ V++L+ A + + K+ TPLH AA N V+ +E+++ + + + G + +H
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 344 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
AA H++ V LLL A I+ LH AA+ GH V +L++ GA+ +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
G+TPLH A + V++ LL G ID + G T LH+A + G +V L+ GA+
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 464 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
N N TPLH AA + H + + L+ N A VN ++KD ++PLH A G + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
++N + G+TPLH+AAR GH + L A A PLH+AA
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642
LL + K G T LH A N++ +KLL G H G TPLH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 682
A +L+ G + N G T LH AA G+A
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
Query: 683 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 732
+ LL AN ++ +K G +H A GH ++L++ + ++ +
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
Query: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792
+PLH+A++ G+ + ++ LLQ D++ + + G + L AA +GHT+ V L+ GAS
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 793 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 833
+ V+ TPL + G+ +L + D V V D
Sbjct: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
Score = 201 bits (511), Expect = 6e-51
Identities = 185/673 (27%), Positives = 287/673 (42%), Gaps = 57/673 (8%)
Query: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
D + A G ++ ++NG +I+ +++G LH+A++ GH ++ L
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
LH+AAL + R+L++ G ++ + G T L+ AA ++E +K L
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDT 219
+GA+ + + G TPL A H + + L+ G ALH AA +D
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
Query: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 279
R +L N + L + E + LL A+ + + G +H A
Sbjct: 460 RNKTILGNAHDNSEELERA-----RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
Query: 280 SRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
+ G+ + LLL+R E+ + +PLH AA NGH + E+LL + + +
Sbjct: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
Query: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEI---DDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394
G + + +AA H +CV L+ A I D++T TPLH + GH ++LL+
Sbjct: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVT--KRTPLHASVINGHTLCLRLLLEIA 632
Query: 395 AKPNS---RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 451
P + + G TPL +A H+ + LLL+ A++D V G T LH GH
Sbjct: 633 DNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
Query: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQ--TPLH 508
V+ LL++ S + + TPLH AA GH LLQ ++ + KD+Q TPLH
Sbjct: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
Query: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ--ACMT 566
A G+ N +++LLE TPLH A H LL S +C
Sbjct: 753 WACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Query: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
KG TPL AA V +LLL A NA +G T L +A + V +L
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL----- 866
Query: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686
+ + Q + V L TPLHLA +GH + L
Sbjct: 867 --------------VNSAQADLTVKDKDLN-------------TPLHLACSKGHEKCALL 899
Query: 687 LLSKQANGNLGNK 699
+L K + +L N+
Sbjct: 900 ILDKIQDESLINE 912
Score = 188 bits (477), Expect = 5e-47
Identities = 164/604 (27%), Positives = 254/604 (42%), Gaps = 82/604 (13%)
Query: 44 DAATSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
D T AAR G+ + ++ LR +G D C + + LHLA+ H +LL
Sbjct: 313 DGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
++T K G T LH AA G E ++ L + GA+ + + + G TPL+ AA H ++
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
L+ GAN N + G T L A + L N + L + T
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE-ELERARELKEKEATLCL 490
Query: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS------------------ 264
LLQND NP + K G+ +H AA Y + +LLL R S
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAA 550
Query: 265 -----------------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DEL 306
++ + G T L +A+ +G+ V L++ GA I K +
Sbjct: 551 YNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR 610
Query: 307 TPLHCAARNGHVRISEILL---DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
TPLH + NGH +LL D+ + K G +P+ +A H+D V LLL+ +A
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 364 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
+D + + T LH GH ++LL++ + G TPLH A + H + L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
Query: 424 LKTGASIDAVT---ESGLTPLHVASFMGHLPIVKNLLQR--------------------- 459
L+ S + G TPLH A + G+ ++ LL++
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIIND 790
Query: 460 -------------GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
+ + + K TPL AA A H E + LL++ A VNA +T
Sbjct: 791 HGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTA 850
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQAC 564
L AA G V +L+ N+A +L +TPLH+A +GH + L +L+K ++
Sbjct: 851 LMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESL 909
Query: 565 MTKK 568
+ +K
Sbjct: 910 INEK 913
Score = 92.4 bits (228), Expect = 4e-18
Identities = 77/290 (26%), Positives = 123/290 (42%), Gaps = 32/290 (11%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
K A T + A G++D L +++T + G LH GH + V LL +
Sbjct: 641 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ 700
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHL 157
E+ + +G T LH AA G + EL+ + + +G+TPL+ A +
Sbjct: 701 EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
Query: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 217
++ LLE + + FTPL A+ H N + L+ + + ++ R+D
Sbjct: 761 NCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSIVSCRDD 812
Query: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
G TPL AA +++ QLLL A VN +G T L
Sbjct: 813 --------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALM 852
Query: 278 IASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 326
+A+ G V +L++ A + K KD TPLH A GH + + ++LD
Sbjct: 853 MAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 315 bits (808), Expect = 2e-85
Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)
Query: 215 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 274
R D RT LL N + + G T L AA+ +L+V LL++RGA + +G T
Sbjct: 524 REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
Query: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334
PL +A+R+G+ +V L+ GA I +D T L AA GH + LL G +
Sbjct: 581 PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
Query: 335 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394
+ + + AA G H D V LLQ+ AE++ + T L AA+ GH + + LLD G
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 395 AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449
A+ N ++G T L +A K H V+ LL+ GA +D + G+TPL VA++ GH
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
Query: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509
+ +V LL+ GA + ++ TPL AA GH V LL A V++ + +T L
Sbjct: 761 VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Query: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
A+ G+ +V+ LL+ + N AG TPLH+AA EGH AL+E+ A + G
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
P +A++ G ++LLE ++ + G +G L VA + DIV+LL G +
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 630 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
+G L+I A +NQ+ +A L+ G + A +G T LH++ +GH EMV +L++
Sbjct: 941 CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
Query: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749
A+ N + + L A +GHV V +LI+HG +VD T G T L +A+ G+I +
Sbjct: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
Query: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 803
V+ LL+H AD N + G + + AA+ GH+ I+ LL K NG SP+ V + P
Sbjct: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
Query: 804 L 804
L
Sbjct: 1121 L 1121
Score = 282 bits (722), Expect = 2e-75
Identities = 206/686 (30%), Positives = 327/686 (47%), Gaps = 42/686 (6%)
Query: 123 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
+ EV++ LV GA+VN++ + + A + + ++ LL+NGA+ N +G T LA
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
A G +VV L++ G + ++ G TP
Sbjct: 551 NAAYSGSLDVVNLLVSRGA-----------------------------DLEIEDAHGHTP 581
Query: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
L +AA + V L+ GA++N T Q+G T L A+ G+ +V LL G +++
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362
D T L AA GH I LL HGA + G + + AA H + V LL + A
Sbjct: 642 ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Query: 363 EIDDITLDHLTPLHVAAHC-----GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 417
E++ +D T L VAA C GH V +L+D+GA+ + +G TPL +A + HV
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
Query: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
V++LLL+ GA +D +G TPL A+ MGH +V LL GA+ + + + T L +A
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Query: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 537
+ G+ EV + LL N + TPLH AA GH + + L+E A N G
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597
P +A++EGH + V LLE +++ G L VAA G + ELL A N
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
Query: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
+G L++ N L + + L G + + G T LH++ Q +E+ + L+ Y
Sbjct: 942 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
Query: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
NA + + L AA +GH ++V LL+ A + G T L + AQEGH+ V
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
Query: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
VL++HG + + G T + VA+ G+ +++K L ++ A ++ SP+H Q+
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119
Query: 778 G----HTDIVTLLLKNGASPNEVSSD 799
+ + +L +K+ +S + D
Sbjct: 1120 PLQSLSSKVQSLTIKSNSSGSTGGGD 1145
Score = 281 bits (719), Expect = 4e-75
Identities = 184/568 (32%), Positives = 280/568 (49%), Gaps = 5/568 (0%)
Query: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
LL+ GASVN NG T L A+ G++ +V LL+ RGA +E + TPL AAR GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377
++ L+ GA I ++G + + AA G H + V LL ++D D T L
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437
AA GH + LL GA+ N G T L A H ++E LL GA ++ G
Sbjct: 651 AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710
Query: 438 LTPLHVASFM-----GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
T L VA+ GH +V L+ RGA + + TPL +AA GH +V LL+
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 770
Query: 493 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 552
A V+ + +TPL AA +GH ++V LL A + + G T L IA+ +G+VE V
Sbjct: 771 GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVV 830
Query: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 612
LL++ + G+TPLH+AA G + E L+E+ A N +G P +A
Sbjct: 831 RTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
Query: 613 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 672
+ D V++LL + ++G L +AA + ++ L +G N + G L
Sbjct: 891 GHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950
Query: 673 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 732
++ A E M L AN + G T LH+ +GH+ + VLI + V+A
Sbjct: 951 YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010
Query: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792
+ L A+ G++K+V+ L++H A V+ G + L AAQ+GH D+V +LL++GA
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070
Query: 793 PNEVSSDGTTPLAIAKRLGYISVTDVLK 820
PN G T + +A + G+ + +L+
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLE 1098
Score = 269 bits (688), Expect = 2e-71
Identities = 185/569 (32%), Positives = 287/569 (50%), Gaps = 11/569 (1%)
Query: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
A T AAR G+ + G +IN +Q+G L A+ GH ++V LL+ +
Sbjct: 576 AHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
++ TAL AA G +++V L+ +GA VN +G T L AA H E+V+
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 163 LLENGANQNVATEDGFTPLAVAL-----QQGHENVVAHLINYGTK----GKVRLPALHIA 213
LL++GA N DG T L+VA +GH +VV+ LI+ G + K + L +A
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
Query: 214 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 273
A +LL+ + D G TPL AA + +V LL GA+V+ G
Sbjct: 756 AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815
Query: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
T L IAS +GNV +VR LLDRG + TPLH AA GH I E L++ GA
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 875
Query: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
+G P +A+Q H DCV++LL+ + ID D L VAA GH + ++L
Sbjct: 876 IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
Query: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
GA N + +G L+I +N + + E L+ GA+++A G T LHV+ + GH+ +V
Sbjct: 936 GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMV 995
Query: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
+ L+ A N ++ + + L AA GH +V + L+++ A V+ T L AA+
Sbjct: 996 QVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055
Query: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
GH ++V++LLE+ A+PN A G T + +AA+ GH + ++ LLEK + + + +P+
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ-IIKLLEKYGASS-LNGCSPSPV 1113
Query: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNG 602
H + ++ + N++G G
Sbjct: 1114 HTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
Score = 156 bits (394), Expect = 2e-37
Identities = 131/456 (28%), Positives = 197/456 (43%), Gaps = 77/456 (16%)
Query: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 494
LTPL F HL I NL A + + TP+ + EV + L++ A
Sbjct: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
Query: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554
VN++ DD+T + + ++ LL+N A+ N + G T L AA G ++ V
Sbjct: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
Query: 555 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 614
L+ + A G TPL +AA+ G +V L+ A+ N ++G T L A +
Sbjct: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
Query: 615 LDIVKLLLPRG-----------GSPHSPAWNGY----------------------TPLHI 641
++V LL G + + AW G+ T L
Sbjct: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
Query: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA-----AQEGHAEMVALLLSKQANGNL 696
AA E+ LL +G N E V G T L +A A +GHA +V+LL+ + A +
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
Query: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP------------------- 737
+K G+TPL + A EGHV V D+L++ G VD T G TP
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
Query: 738 --------------LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
L +AS GN+++V+ LL D N + G++PLH AA +GH I
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863
Query: 784 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
L++ GA NE+ +DG P +A + G+ +L
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 91.7 bits (226), Expect = 6e-18
Identities = 54/160 (33%), Positives = 84/160 (52%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
K AD + A L A L NG ++ + G LH++ +GH++MV L+
Sbjct: 942 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
+ + +AL AA G +VV+ L+ +GA V+ +G T L +AAQE H++VV
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
+ LLE+GA+ N A + G T + VA + GH ++ L YG
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
Score = 86.3 bits (212), Expect = 3e-16
Identities = 56/196 (28%), Positives = 99/196 (50%), Gaps = 4/196 (2%)
Query: 34 NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93
N+S ++ D + AA G+ D +G D+N + +G L++ + E + M
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
Query: 94 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153
L +E + +G TALH++ G E+V+ L+ Y A+VNA + + L AA
Sbjct: 962 AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021
Query: 154 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPA 209
+ H++VV+ L+E+GA + G T L +A Q+GH +VV L+ +G + A
Sbjct: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081
Query: 210 LHIAARNDDTRTAAVL 225
+ +AA+N ++ +L
Sbjct: 1082 MRVAAKNGHSQIIKLL 1097
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 305 bits (782), Expect = 2e-82
Identities = 297/1012 (29%), Positives = 444/1012 (43%), Gaps = 121/1012 (11%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + AA G++ L + D+N + G L A G+V +V L
Sbjct: 295 DRGIKGDI-TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L +E + G+T L A AG EV R L+ GA +N S + + L +A + H
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
LE+V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 471
Query: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
+AA AA+L++ + + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+ T L +A G + + L+ GA IE TPL AA+ GH+ + + LL GA
Sbjct: 532 ETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGA 588
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
+ A T G + + A + H D +LLQ A+++ + TPL AA GH +
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
Query: 390 LLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448
L+ KGA N + A N T L +AC H+ V+ELLL GA + G T L A+ G
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
Query: 449 HLPIVKNLLQRG----ASPNVSNVKVETPLHMAARAGHTEV------------------- 485
H +V LL ++P ++ P H RA V
Sbjct: 709 HTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768
Query: 486 -AKYLLQNKAKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLAT 533
++NKA + TP H AA I + L + + + T
Sbjct: 769 ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQT 828
Query: 534 TAGH-TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
+ H T L +A GH E V LLE+ AS KKGFTPL +AA G V V E+LL+
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
Query: 593 AHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
A A + TPL +A ++V+LLL RG + + YTPL +AA V +
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 652 RSLLQYGGSANAE--SVQGVTPLHLAAQEGH----------------------------- 680
+ LL G N+ S G++PL LAA GH
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
Query: 681 -----AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRM 733
E+V+LLL ++AN K+GLTPL A G+ V VL+ G V+A
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
T L +A+ G+ K + L+ A ++ + K G +PL AA GH D+V LL++ GA
Sbjct: 1069 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1128
Query: 794 NEVSSDGTTPLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPE 841
+ + TPL A R G++ V L K V S ++DK + E
Sbjct: 1129 DAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME 1188
Query: 842 TVDEILDVSEDEGTAHITIMGEELISFK----------AERRDSRDVDEEKELLDFVPKL 891
++ + D E + +I+ EEL K A +R+ R K+ + KL
Sbjct: 1189 SIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKL 1248
Query: 892 DQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 943
++ I E +++ ++++ K DE ++ P+ T+ I
Sbjct: 1249 EE---------IEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
Score = 293 bits (750), Expect = 1e-78
Identities = 265/859 (30%), Positives = 406/859 (47%), Gaps = 67/859 (7%)
Query: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
S A G+++ L G +N + G + L LA G+ ++ LL +E
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 108 TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
KG+ T L AA G ++V+ L+ + A+VNAQS G T L A +++VVK LLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 221
GA+ E+G TPL A GH V L+ G + + AL +A
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
Query: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
LL+ + + + T L A ++ VA+LLL+ GA VN + +PL +A+
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
Query: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 340
G+V + LL++RGA +E + TPL AAR GH + +LL GA I A+T+ +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
+ +A G L+ L++ A DI L TPL AA GH + K LL GA ++
Sbjct: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
G T L AC+ H V ++LL+ GA ++ +E G TPL A+ GH+ V+ L+ +G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 461 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
A+ N + + T L +A GH V + LL + A + KD T L AA+ GHT++V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 520 KLLLENNAN------PNLA--TTAGH------------TPLHIAARE-----GHVETVLA 554
LL+ N P++ T H P+ + +E +V T L
Sbjct: 714 CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP 773
Query: 555 LLEKEASQACMTKKGFTPLH-VAAKYGK---------VRVAELL-----LERDAHPNAAG 599
+ K S TP H +AA + + + +L ++ DA +
Sbjct: 774 IRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTES-- 830
Query: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
N T L +A + ++V+ LL RG S G+TPL +AA V V LL G
Sbjct: 831 -NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 660 SANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 718
A+S + TPL LA G E+V LLL++ AN N S TPL L A G+V +
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 719 VLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSPLHQAA 775
+L+ G +++ T ++G +PL +A+ G+ VK LL +D+NA+ + + L A
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 835
QG T++V+LLL A+ + G TPL A GY +V +V+ D+ +D +
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY---AEVGRVLLDKG-----ADVN 1061
Query: 836 RMSFPETVDEILDVSEDEG 854
P + D L ++ D+G
Sbjct: 1062 APPVPSSRDTALTIAADKG 1080
Score = 282 bits (721), Expect = 3e-75
Identities = 257/851 (30%), Positives = 383/851 (45%), Gaps = 115/851 (13%)
Query: 50 LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
L ++ S LD+A L +T N Q+ L A EG V V +LL + +
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
Query: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 166
T++G + L +A AG E+ + L+ ANV + KG TPL AA H+++VK LL +
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226
A+ N + G T L A G+ +VV VLL
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
Query: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 284
++ + + ++ G TPL A ++ VA+LLL GA +N T N + L +A +G+
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
Query: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
+ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA + + SP+ +
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 403
AA G H++ LL++ A ++++ + TPL AA GH + +LL +GA N++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
T L +AC + V + L+K GA I+ TPL A+ GHL +VK LL GA+
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
Query: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523
+ + +T L A GHT+VA LLQ A + +++ +TPL AAR GH V+ L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 524 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
AN N T HT L +A GH+ V LL A K G T L AAK G
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 636
V LL+ + +A +T L H N + + +++P P P N
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
Query: 637 T--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP----------------------- 671
T P+ A + + + +A+ Q TP
Sbjct: 770 TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
Query: 672 ------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
L LA GH E+V LL + A+ +K G TPL L A GHV V ++L+ +G
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 726 MVDATTR----------------------------------MGYTPLHVASHYGNIKLVK 751
++A + YTPL +A+ G + ++K
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 752 FLLQHQADVNAKT--KLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAK 808
LL A++N++T KLG SPL AA GHT V LLL G+ N ++ ++ T L +A
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 809 RLGYISVTDVL 819
G V +L
Sbjct: 1010 FQGRTEVVSLL 1020
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 297 bits (760), Expect = 8e-80
Identities = 260/831 (31%), Positives = 366/831 (44%), Gaps = 92/831 (11%)
Query: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
AA G+L+ + G D+ ++ G LH A+ G +++V LL ++ G
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 170
NTALHIA GQD V ELVN GANVN + KGFTPL++AA N ++ L+ NGA+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 226
N +++G +PL +A G LI G++ K LH+AAR + L+
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Query: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA--------------SVNF---TP 269
N + PLH+A + + + LL+ G S F TP
Sbjct: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
Query: 270 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
N G T LH A+ GNV + LLL GA + + K TPLH AA NG + + L+ G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Query: 329 APIQAKTKNGLSPIHMAAQGDHLDCVR--LLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 386
A + G SP+H AA D +DAE D+ PL +
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
Query: 387 AKVLLDKGAKPNSRALNGFT-----------------------------------PLHIA 411
+ LLD GA P+ R G+T PLH+A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 412 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 471
H ++ L +T ++D G T L +A+ G V+ L GAS + K +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
Query: 472 -TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNA 527
TPLH AA +GHT+ L+ + + + D QTPL A GH + V LLLE +
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 528 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 587
+ A G T LH A G + + ALL+ +A C KG TP+H+A+ G V
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 588 LLER--DAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRGGSPHSP----AWNGYTPL 639
LL+ P AG + G +P+H A + + D ++LLL HSP N +TPL
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPL 827
Query: 640 HIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
H A NQ LL G+ N+ +G TPLH AA + + +LL QA N
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887
Query: 698 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQ 755
+ +G T L A+ G + L+ G D T T LH+A G+ K +L
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 756 HQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
D +NA PLH AA+ G +V LL +GA+ V +G TP
Sbjct: 947 ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 286 bits (732), Expect = 1e-76
Identities = 226/744 (30%), Positives = 329/744 (44%), Gaps = 60/744 (8%)
Query: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 202
PL A +E V+ LL N NV ++ TPL A G ++ L+ N K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262
+ L LH AA + + + +LL + + + K TPLH+AA A+ L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
+S+N ++G + LH A G++ V LLL++GA + K E PLH AA GH+ + +
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382
+L+ GA + K + G +H AA ++ V+ LL+ AEID+ T LH+A + G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Query: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 441
VA L++ GA N GFTPLH+A N +ELL+ GA ++ ++ G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Query: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
H+A+ G + L+Q G+ + ++ TPLH+AAR GH + L+ N A +
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
Query: 502 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 543
D PLH A G ++ + LL + + N G T LH A
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
Query: 544 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603
A G+VE + LL A K G TPLH AA G + A L+ A N A G
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
Query: 604 TPLHVAV---------------HHNNLD-------------IVKLLLPRGGSPHSPAWNG 635
+PLH A H D ++ LL G P G
Sbjct: 491 SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
Query: 636 YTPLHIAAKQNQVEVARSLLQ--YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
YT +H AA + LL+ + + ES V+PLHLAA GH E + L N
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
Query: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKF 752
++ + G T L L + G +VL HG R +TPLH A+ G+ +
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
Query: 753 LLQ--HQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 809
L+ +AD+ + G +PL A GH D V LLL+ G++ + G T L R
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL---HR 727
Query: 810 LGYISVTDVLKVVTDETSFVLVSD 833
D L + D +FVL D
Sbjct: 728 GAVTGCEDCLAALLDHDAFVLCRD 751
Score = 285 bits (730), Expect = 2e-76
Identities = 253/863 (29%), Positives = 371/863 (42%), Gaps = 98/863 (11%)
Query: 47 TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105
T RAA S N +K L L + D+N ++ LH+A+ K L L
Sbjct: 76 TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
Query: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
+ G +ALH A +G E V L+N GA++N +K PL+ AA HLEV+K L+
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
Query: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 221
GA+ G+ L A G VV +L+ G + ALHIA
Sbjct: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
Query: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 280
A L+ N + + GFTPLH+AA N + +LL+N GA VN+ + G +PLH+A+
Sbjct: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
Query: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
G ++L+ G++I+ K TPLH AAR GH + L+ +GA + + +
Sbjct: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
Query: 341 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 382
P+H+A DC R LL A D T D+L T LH AA G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 442
+ +LL GA R G TPLH A + L+ GA ++ G +PLH
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
Query: 443 VASFMG-------HLP---------------------IVKNLLQRGASPNVSNVKVETPL 474
A+ H P ++ LL GA P++ + + T +
Sbjct: 495 YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAV 554
Query: 475 HMAARAGHTEVAKYLLQNKAKV--NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532
H AA G+ + + LL+ + ++ +PLH AA GH +K L E N ++
Sbjct: 555 HYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVR 614
Query: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLL-- 589
G T L +A G E V L AS K+ +TPLH AA G LL+
Sbjct: 615 DHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDS 674
Query: 590 -ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
ER + G TPL +A+ + ++D V LLL +G + + G T LH A
Sbjct: 675 GERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734
Query: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL----GNKSGLTP 704
+ +LL + +G TP+HLA+ GH ++ LL + + + SG +P
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794
Query: 705 LHLVAQEGHVPVADVLIKHGVM------------------VDATTRM------------- 733
+H + GH ++L++H D+TT M
Sbjct: 795 MHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSR 854
Query: 734 ---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 790
G TPLH A+ N+ ++ LLQHQA+VNA G + L AA+ G T V LL G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Query: 791 -ASPNEVSSDGTTPLAIAKRLGY 812
A + + T L +A G+
Sbjct: 915 KADLTVLDENKNTALHLACSKGH 937
Score = 260 bits (664), Expect = 1e-68
Identities = 208/698 (29%), Positives = 305/698 (43%), Gaps = 86/698 (12%)
Query: 208 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267
P L A + D LL N +VL + TPLH AA+ ++ + QLLL GA+VN
Sbjct: 10 PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
+TPLH A+ N ++ LLL A + + K TPLH AA N + +E L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
+ + ++G S +H A HL+ V LLL A ++ PLH AA GH V
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
Query: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
K+L+ +GA + G+ LH A + V++ LL+ GA ID G T LH+A ++
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
Query: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 506
G + L+ GA+ N N K TPLH+AA + + + + L+ N A VN ++K+ ++P
Sbjct: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
LH AA G ++L++N + + A G+TPLH+AAR GH + L+ A A
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
Query: 567 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 608
PLH+A +G LL + H +AG + G T LH
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
Query: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
A N++ + LLL G G TPLH AA + A +L+ G N +G
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Query: 669 VTPLHLAA-------QEGHAE---------------------MVALLLSKQANGNLGNKS 700
+PLH AA E H + LL A+ +L ++
Sbjct: 490 CSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQ 549
Query: 701 GLT-----------------------------------PLHLVAQEGHVPVADVLIKHGV 725
G T PLHL A GH L + V
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQGHTDIVT 784
+D G T L +A+ G+ + V+ L H A K K ++PLH AA GHTD +
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLH 669
Query: 785 LLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 819
LL+ +G + + + G TPL +A G++ +L
Sbjct: 670 LLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 245 bits (626), Expect = 3e-64
Identities = 195/656 (29%), Positives = 290/656 (44%), Gaps = 52/656 (7%)
Query: 234 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 293
+LS T PL A ++ + LL++ ++N Q TPLH A+ G+V +++LLL
Sbjct: 3 ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
Query: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
GA + K LTPLH AA + + ++ +LL H A + A+ K +P+H+AA C
Sbjct: 63 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
Query: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
L + ++ + LH A H GH +LL+KGA N PLH A
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
Query: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
H+ V++LL+ GA + G LH A+ G + +VK LL+ GA + N T
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
Query: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA-RIGHTNMVKLLLENNANPNLA 532
LH+A G VA L+ A VN TPLH AA ++LL+ N A+ N
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
Query: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
+ G +PLH+AA G L++ + C K G TPLHVAA+YG + L+
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG 362
Query: 593 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG---------GSPH---------SPAWN 634
A G + + PLH+AV D + LL G + H +P
Sbjct: 363 ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNL 422
Query: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
G T LH AA VE LL G G TPLH AA G + L++ A
Sbjct: 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV 482
Query: 695 NLGNKSGLTPLHLVA-------QEGHVPVA---------------------DVLIKHGVM 726
N + G +PLH A E H P + + L+ +G
Sbjct: 483 NEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
Query: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVT 784
R GYT +H A+ YGN + ++ LL+ + + ++ + SPLH AA GH + +
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
Query: 785 LLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFP 840
L + + + G T L +A G T+ ++V+T + L+ ++ R P
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP 655
Score = 197 bits (501), Expect = 8e-50
Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)
Query: 55 SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 108
SG L + L N G DINT + G LH A+ G+V+ + LL L
Sbjct: 394 SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
Query: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168
K G T LH AA G + LV GA VN KG +PL+ AA + + +
Sbjct: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
Query: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 224
+ + A ED PL + ++ + L++ G +R A+H AA + + +
Sbjct: 511 SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
Query: 225 LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
LL+ N DV S +PLH+AA+ + + L +++ G T L +A+ R
Sbjct: 569 LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
Query: 283 GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 338
G+ V +L GA K K + TPLH AA +GH +L+D G G
Sbjct: 629 GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
Query: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
+P+ +A H+DCV LLL+ + D L T LH A G LLD A
Sbjct: 689 QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
Query: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 454
R G TP+H+A H V+ LL+ S D V SG +P+H AS+ GH ++
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
Query: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 512
LL+ + TPLH A + LL VN++ +TPLH AA
Sbjct: 809 LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
Query: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 571
+ + +++LL++ A N G T L AA G V LL + +A + + T
Sbjct: 868 ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
Query: 572 PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
LH+A G + A ++L NA PLH+A + +V+ LL G +
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Query: 629 HSPAWNGYTPLHIAAKQNQVEVARSLL 655
+ G+TP A V +L+
Sbjct: 988 LAVDEEGHTPALACAPNKDVADCLALI 1014
Score = 110 bits (274), Expect = 2e-23
Identities = 99/353 (28%), Positives = 161/353 (45%), Gaps = 17/353 (4%)
Query: 37 RDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96
++RK+K + + + +L +D + + G L LA GHV V
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
Query: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156
LL K + +G TALH A+ G ++ + L+++ A V + KG TP+++A+ H
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
Query: 157 LEVVKFLLENGANQNV----ATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLP 208
V++ LL+ + + G++P+ A GHE+ + L+ + +G P
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTP 826
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSK--TGFTPLHIAAHYENLNVAQLLLNRGASVN 266
LH A N+ T +LL V S+ G TPLH AA +N++ ++LL A VN
Sbjct: 827 -LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
Query: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILL 325
T G T L A+ G V LL RG A + +++ T LH A GH + + ++L
Sbjct: 886 ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945
Query: 326 ----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374
D G I A P+H+AA+ V+ LL + A + + + TP
Sbjct: 946 AETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 48.9 bits (115), Expect = 5e-05
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)
Query: 47 TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 102
T+ + AA +G A++ L R D+ ++N LHLA +GH K + +L +
Sbjct: 893 TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
Query: 103 -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
++ T LHIAA G VV+ L+++GA V A ++G TP A
Sbjct: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 296 bits (758), Expect = 1e-79
Identities = 240/783 (30%), Positives = 356/783 (45%), Gaps = 103/783 (13%)
Query: 122 GQDEVVRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 179
G E V+ LV VN++ G TPL+ AA +VV++LL+NGAN + G
Sbjct: 35 GDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93
Query: 180 PLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVL 235
PL A GH VV L+ +G R LH AA VLLQ+ P +
Sbjct: 94 PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153
Query: 236 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDR 294
+ G T L +A + A T + L ++R GN M+ LL
Sbjct: 154 NTDGRTALDLA-------------DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200
Query: 295 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 354
+ TPLH AA V+I ++LL HGA + AK K L P+H A H +
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
Query: 355 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 414
LL+++ A ++ + L TPLH AA V +LL GA P + + + +A
Sbjct: 261 ELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTP 320
Query: 415 NHVRVMELLLKTGASIDAVTESGLT---------------------PLHVAS---FMGHL 450
+ K + + A E+ +T LH A+ +
Sbjct: 321 QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRK 380
Query: 451 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510
I + LL++GA+ N + TPLH+A+ H +V + +++++AKVNA QT LH A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Query: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHI--------------------------AA 544
A GH +LLL +PN+ + G T L + AA
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500
Query: 545 REGHVETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
+ G VETV L + S C +G TPLH AA Y +V V E LL+ A +A K G
Sbjct: 501 KAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559
Query: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
L PLH A + + ++ +LL+ G + +TPLH AA + + E+ + LLQ+G
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
Query: 663 AESVQGVTPLHLAAQEGHAEMVALL--------------------LSKQANGNLGNKSGL 702
++ G TPL L ++G ++ LL LS N N + G
Sbjct: 620 KKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGR 678
Query: 703 --TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
TPLHL A ++ VA+ L++HG V+A + G PLH A+ YG++ + L+++ A V
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738
Query: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
NA K ++PLH+AAQ+G T + LLL +GA P + +G TPL + +S DV
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL------VSADDVSA 792
Query: 821 VVT 823
++T
Sbjct: 793 LLT 795
Score = 281 bits (718), Expect = 6e-75
Identities = 236/774 (30%), Positives = 348/774 (44%), Gaps = 87/774 (11%)
Query: 45 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 102
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
Query: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
Query: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
Query: 343 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 379
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
Query: 380 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
Query: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 476
T LH A++ GHL + LL G PN+ +++ T L M
Sbjct: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADR 494
Query: 477 ----AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPN 530
AA+AG E K L ++ VN + + TPLH AA ++V+ LL++ A+ +
Sbjct: 495 QLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553
Query: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
G PLH A GH E L++ A FTPLH AA GK + +LLL+
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Query: 591 RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL--------------LPRGGSPHSP----- 631
A P ++G TPL + V + DI LL L R SP
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672
Query: 632 ---AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
TPLH+AA N +EVA LLQ+G NA+ G+ PLH AA GH ++ ALL+
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
Query: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
A N +K TPLH AQ+G + +L+ HG + G TPL + S
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786
Score = 229 bits (583), Expect = 3e-59
Identities = 204/644 (31%), Positives = 289/644 (44%), Gaps = 81/644 (12%)
Query: 279 ASRRGNVIMV-RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
A R G+V V RL+ + TPLH AA G + E LL +GA +QA+
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
Query: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397
GL P+H A H + V LLL++ A+ + + TPLH AA G V VLL GA+P
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 398 NSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTES 436
R +G T L +A KK N ++M LL + A
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
Query: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496
TPLH+A+ + IV+ LLQ GA + + PLH A GH EV + L+++ A V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
Query: 497 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT---------------------- 534
NA TPLH AA + LLL A+P L
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
Query: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGK-VRVAELLLER 591
GH+ L AARE V + L E + T LH AA Y K ++ ELLL +
Sbjct: 331 KGHSLLQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389
Query: 592 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
A+ N K LTPLHVA + D+V++++ ++ G T LH AA ++
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 652 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 685
R LL YG N S+QG T L + AA+ G E V
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVK 509
Query: 686 LLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 743
L + Q + N + G TPLH A V V + L++HG V A + G PLH A
Sbjct: 510 KLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACS 568
Query: 744 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
YG+ ++ + L++H A VN ++PLH+AA +G +I LLL++GA P + + DG TP
Sbjct: 569 YGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTP 628
Query: 804 LAIAKRLGYISVTDVLK---VVTDETSFVLVSDKHRMSFPETVD 844
L + K G + D+L+ + D ++ ++S P+ V+
Sbjct: 629 LDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVN 671
Score = 191 bits (486), Expect = 4e-48
Identities = 173/584 (29%), Positives = 256/584 (43%), Gaps = 92/584 (15%)
Query: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
L++G D++ ++ L LH A GH ++ L+ + T LH AA +
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290
Query: 125 EVVRELVNYGAN---VNAQSQKGF----TP--------------LYMAAQENH------- 156
EV L++YGA+ +N ++ TP L AA+E
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350
Query: 157 --LEVVKF---------------------------LLENGANQNVATEDGFTPLAVALQQ 187
LE+V F LL GAN N T++ TPL VA ++
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410
Query: 188 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 243
H +VV ++ + K + +LH AA +T +LL +P+++S GFT L
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
Query: 244 HIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKT 302
+ N NV QLL G S+ + + L A++ G+V V+ L +
Sbjct: 471 QMG----NENVQQLL-QEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362
+ TPLH AA V + E LL HGA + AK K GL P+H A H + LL+++ A
Sbjct: 524 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Query: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 422
++ L TPLH AA G + + K+LL GA P + +G TPL + K + +L
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDL 642
Query: 423 LLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNLLQRG 460
L A +DA + L TPLH+A+ +L + + LLQ G
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
Query: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
A N + PLH AA GH +VA L++ A VNA K TPLH AA+ G T +
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762
Query: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564
LLL + A+P L G TPL + + + + A + A +C
Sbjct: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSC 806
Score = 128 bits (321), Expect = 6e-29
Identities = 97/312 (31%), Positives = 147/312 (47%), Gaps = 17/312 (5%)
Query: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHVKMVVEL 97
++A L AA++G+++ ++ + + N + G LH A+ V +V L
Sbjct: 490 SEADRQLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYL 545
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
L + K G LH A G EV LV +GA VN FTPL+ AA +
Sbjct: 546 LQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605
Query: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 217
E+ K LL++GA+ DG TPL + ++ G ++ L +G L L A +
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LDAAKKGC 657
Query: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
R + ++ N TPLH+AA Y NL VA+ LL GA VN + G+ PLH
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
Query: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA K +
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Query: 338 GLSPIHMAAQGD 349
G +P+ + + D
Sbjct: 778 GQTPLDLVSADD 789
Score = 125 bits (315), Expect = 3e-28
Identities = 118/429 (27%), Positives = 187/429 (43%), Gaps = 49/429 (11%)
Query: 16 AQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCN 75
A A K K+ R + +K + T A+ + D +++ +N +
Sbjct: 371 AAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALD 430
Query: 76 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHI------------------ 117
G LH A+ GH++ LL + +G TAL +
Sbjct: 431 NLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 118 --------AALAGQDEVVRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENG 167
AA AG E V++L +VN + +G TPL+ AA N + VV++LL++G
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAA 223
A+ + + G PL A GH V L+ +G V + LH AA
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 609
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
+LLQ+ +P ++ G TPL + + ++ LL G L A+++G
Sbjct: 610 LLLQHGADPTKKNRDGNTPLDLVKDGDT-DIQDLL------------RGDAALLDAAKKG 656
Query: 284 NVIMVRLLL--DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
+ V+ L D +T+ + TPLH AA ++ ++E LL HGA + A+ K GL P
Sbjct: 657 CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+H AA H+D LL++Y+A ++ TPLH AA G ++ +LL GA P +
Sbjct: 716 LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKN 775
Query: 402 LNGFTPLHI 410
G TPL +
Sbjct: 776 QEGQTPLDL 784
Score = 90.5 bits (223), Expect = 1e-17
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 660 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 715
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
Query: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
Query: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
+G D+ +LL++GA P ++DG T L +A
Sbjct: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 294 bits (752), Expect = 6e-79
Identities = 235/762 (30%), Positives = 348/762 (45%), Gaps = 97/762 (12%)
Query: 127 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
Query: 185 LQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240
GH VV+ L+ G R LH AA VLLQ+ +P++ + G
Sbjct: 257 CSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGK 316
Query: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDRGAQIE 299
+ L +A + A T + L A+R GN ++ LL
Sbjct: 317 SALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363
Query: 300 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 359
+ TPLH AA VRI ++LL HGA + AK K GL P+H A H + LLL+
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
Query: 360 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419
+ A ++ + L TPLH AA V +LL GA P +G + + +A
Sbjct: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
Query: 420 MELLLKTGASIDAVTESGL---------------------TPLHVASFMGH---LPIVKN 455
+ K + + A E+ L T LH A H + +
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTEL 543
Query: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
LL++GA+ N N TPLH+AA H +V + L ++ AK+NA QT LH AA GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 516 TNMVKLLLENNANPNLATTAGHTPLHI--------------------------AAREGHV 549
+LLL ++P++ + G T + A++ G +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663
Query: 550 ETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 607
ETV L + + C +G TPLH AA Y +V V E LL A +A K GL PLH
Sbjct: 664 ETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
Query: 608 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667
A + + ++ +LL+ G S + +TPLH AA + + E+ + LL++G ++
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
Query: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----------------------TPL 705
G TPL L +EG ++ LL A + K L TPL
Sbjct: 783 GNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPL 841
Query: 706 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 765
HL A ++ VA+ L++HG V+A + G PLH A+ YG++ + L+++ VNA K
Sbjct: 842 HLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK 901
Query: 766 LGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
++PLH+AAQ+G T + LLL +GA P + +G TPL +A
Sbjct: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 290 bits (742), Expect = 9e-78
Identities = 236/774 (30%), Positives = 347/774 (44%), Gaps = 87/774 (11%)
Query: 45 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 102
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
Query: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
Query: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
Query: 343 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 379
MA + + + LLQ E D + L+ H T LH A
Sbjct: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
Query: 380 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
Query: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 476
T LH A+ GHL + LL G+ P++ +++ T M
Sbjct: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
Query: 477 ----AARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLLLENNANPN 530
A++AG E K L ++ VN + + + TPLH AA ++V+ LL + A+ +
Sbjct: 653 RLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
Query: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
G PLH A GH E L+ AS FTPLH AA GK + +LLL+
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
Query: 591 RDAHPNAAGKNGLTPLHVAVHHNNLDIV----------------------KLLLPRGGSP 628
A P ++G TPL + V + DI KL P +
Sbjct: 772 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830
Query: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890
Query: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
N +K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 891 KYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
Score = 234 bits (596), Expect = 8e-61
Identities = 199/617 (32%), Positives = 279/617 (45%), Gaps = 78/617 (12%)
Query: 279 ASRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 336
A R G+V V+ L+D A + K + +PLH AA G + E LL GA + A+
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
GL P+H A H + V LLL A+ + + TPLH AA G V VLL GA
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
Query: 397 PNSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTE 435
PN R +G + L +A KK N ++M LL + A
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367
Query: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
TPLH+A+ + IV+ LLQ GA + + PLH A GH EV + LL++ A
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA------------ 543
VNA TPLH AA + LLL + A+P L G + + +A
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
Query: 544 ---------AREGHVETVLALLEKEASQACMTKKGFTPLH--VAAKYGKVR-VAELLLER 591
ARE + V L E + T LH VA+ + K + V ELLL +
Sbjct: 488 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547
Query: 592 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
A+ N K+ +TPLHVA + D++++L G ++ G T LH AA ++
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607
Query: 652 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 685
R LL YG + S+QG T + A++ G E V
Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
Query: 686 LLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 743
L S Q N N + G TPLH A V V + L+ HG V A + G PLH A
Sbjct: 668 QLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
Query: 744 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
YG+ ++ + L++H A VN ++PLH+AA +G +I LLLK+GA P + + DG TP
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP 786
Query: 804 LAIAKRLGYISVTDVLK 820
L + K G + D+L+
Sbjct: 787 LDLVKE-GDTDIQDLLR 802
Score = 191 bits (485), Expect = 6e-48
Identities = 170/588 (28%), Positives = 250/588 (42%), Gaps = 100/588 (17%)
Query: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124
L++G D++ ++ GL LH A GH ++ LL + T LH AA +
Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRV 448
Query: 125 EVVRELVNYGA-----NVNAQSQKGFTP----------------LYMAAQENHL------ 157
EV L+++GA N + +S P L AA+E L
Sbjct: 449 EVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKT 508
Query: 158 ------------------------------EVVKFLLENGANQNVATEDGFTPLAVALQQ 187
+V + LL GAN N +D TPL VA ++
Sbjct: 509 LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAER 568
Query: 188 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 243
H +V+ L +G K + ALH AA +T +LL +P ++S GFT
Sbjct: 569 AHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT-- 626
Query: 244 HIAAHYENLNVAQLLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQI 298
AA N V Q+L R + V++ L AS+ G++ V+ L +
Sbjct: 627 --AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNC 677
Query: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 358
TPLH AA V + E LL HGA + AK K GL P+H A H + LL+
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737
Query: 359 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 418
++ A ++ L TPLH AA G + + K+LL GA P + +G TPL + K+
Sbjct: 738 RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTD 796
Query: 419 VMELLLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNL 456
+ +LL A +DA + L TPLH+A+ +L + + L
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856
Query: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
L+ GA N + PLH AA GH ++A L++ VNA K TPLH AA+ G T
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916
Query: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564
+ LLL + A+P + G TPL +A + ++ + EA C
Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
Score = 154 bits (389), Expect = 8e-37
Identities = 130/450 (28%), Positives = 200/450 (44%), Gaps = 49/450 (10%)
Query: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTE 484
G + AV+ L L A G + VK L+ A+ N ++ + +PLH AA G +
Sbjct: 173 GTGVPAVS-GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKD 230
Query: 485 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 544
V ++LLQ A V+A+ PLH A GH +V LLL A+PN +TPLH AA
Sbjct: 231 VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA 290
Query: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVA---------AKYGKVRVAE--------- 586
+G ++ + LL+ A G + L +A +Y K + E
Sbjct: 291 IKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEK 350
Query: 587 ---LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 643
LL + + +A+ TPLH+A +N + IV+LLL G H+ G PLH A
Sbjct: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410
Query: 644 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703
EV LL++G NA + TPLH AA + E+ +LLLS A+ L N G +
Sbjct: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
Query: 704 PLHLV---------------------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
+ + A+E + + ++ + T LH A
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 743 ---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + +
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 800 GTTPLAIAKRLGYISVTDVLKVVTDETSFV 829
G T L A G++ +L + S +
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSII 620
Score = 135 bits (341), Expect = 3e-31
Identities = 99/311 (31%), Positives = 150/311 (48%), Gaps = 11/311 (3%)
Query: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELL 98
+ +D L A+++G+L+ + L + ++N + G + LH A+ V +V LL
Sbjct: 646 RTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
Query: 99 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 158
H + K G LH A G EV LV +GA+VN FTPL+ AA + E
Sbjct: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
Query: 159 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 218
+ K LL++GA+ DG TPL + +++G ++ L +G L L A +
Sbjct: 765 ICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAKKGCL 816
Query: 219 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
R + + N TPLH+AA Y NL VA+ LL GA VN + G+ PLH
Sbjct: 817 ARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876
Query: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K + G
Sbjct: 877 AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEG 936
Query: 339 LSPIHMAAQGD 349
+P+ +A D
Sbjct: 937 QTPLDLATADD 947
Score = 117 bits (294), Expect = 8e-26
Identities = 112/417 (26%), Positives = 177/417 (42%), Gaps = 56/417 (13%)
Query: 16 AQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCN 75
A A K K+ + R + +K D T AA + D ++G +N +
Sbjct: 529 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD 588
Query: 76 QNGLNGLHLASKEGHVKMVVELLH-----------------------KEIILETT---TK 109
G LH A+ GH++ LL ++I+ E+T T
Sbjct: 589 TLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTS 648
Query: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENG 167
+ L A+ AG E V++L + NVN + +G TPL+ AA N + VV++LL +G
Sbjct: 649 DVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
Query: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAA 223
A+ + + G PL A GH V L+ +G V + LH AA
Sbjct: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN-------------FTPQ 270
+LL++ +P ++ G TPL + + ++ LL A ++ TP+
Sbjct: 768 LLLKHGADPTKKNRDGNTPLDLVKEGDT-DIQDLLRGDAALLDAAKKGCLARVQKLCTPE 826
Query: 271 N---------GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
N TPLH+A+ N+ + LL+ GA + + K L PLH AA GHV I+
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378
+L+ + + A K +P+H AAQ LLL + A+ + TPL +A
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 235 bits (599), Expect = 4e-61
Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)
Query: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
TPLH ++ +LLL V+ +G TPL IA++ + LLL GA
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
+D PLH AA+NG + +LLDHGA + A+ + G +P+H+AAQ + + RLL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
A+ + + TPLHVAA+ GH + K+L +GA+ +++ N TPLH+A ++ VR +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
+ LLK+GA DA+ +SG PLH A+ G I K LL+ GAS + + TPLH+AA
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
GH E+ L ++ A + A + TPLH AAR G +V LL+ A+PN A +G TPL
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
H+A + +V+ LLE A+ K G+TP H+AA G + ++L+E A +
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 638
TPL +A+ I+ L G P G P
Sbjct: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 231 bits (590), Expect = 4e-60
Identities = 134/389 (34%), Positives = 208/389 (53%)
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362
++++TPLH G V +LL H + +T +G +P+ +AAQ D LLL + A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 422
+ + + D PLH AA G A++LLD GA +++ G+TPLH+A + N V L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 423 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 482
L+ A + G TPLHVA++ GH+ +VK L +GA + + TPLH+A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 483 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
++LL++ A +A + PLH AA G + K+LL A+ L T G TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
AA +GH+E + L E A+ + +TPLH+AA++G+ V LL+ A PNAA ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
TPLH+AV + V LL + H+ G+TP H+AA + + + L++ G +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
+ TPL LA + +++ L K+
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
Score = 223 bits (569), Expect = 1e-57
Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)
Query: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
N TPLH + V + LLL +D T SG TPL +A+ + LL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
N + PLH AA+ G A+ LL + A V+A+ ++ TPLH AA+ N+ +LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
+ A+PNL G TPLH+AA GHV V L + A + TPLH+A + GKV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642
R + LL+ A P+A ++G PLH A I K+LL G S P G+TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
A + +E+ L + + A TPLHLAA+ G +V+ LL A+ N +SG
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
TPLHL Q L++H V A ++G+TP H+A+ GN ++K L++ A ++
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
Query: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
+ + +PL A + I++ L G P+ + G+ P
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 218 bits (556), Expect = 3e-56
Identities = 132/377 (35%), Positives = 198/377 (52%)
Query: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
+ E+ +TPLH G + V+ LL + TPL +AA+ ++ LL +
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 493 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 552
A N +D PLH AA+ G +LLL++ A + G TPLH+AA+
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 612
L+ ++A +G TPLHVAA +G V + +LL + A +A +N TPLH+AV
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 613 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 672
+ ++ LL G P + +GY PLH AA + + + + LL+YG S + QG TPL
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 673 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 732
HLAA +GH E++ LL AN TPLHL A+ G V L++ G +A +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
Query: 733 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 792
G+TPLH+A V LL+H A+V+A+ K+G++P H AA +G+T I+ +L++ GA
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Query: 793 PNEVSSDGTTPLAIAKR 809
+ TPL +A R
Sbjct: 718 LDVQDGVSCTPLQLALR 734
Score = 217 bits (553), Expect = 8e-56
Identities = 134/378 (35%), Positives = 193/378 (51%)
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+N +TPLH +G+V VRLLL ++ +T TPL AA++ + +LL HGA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
++G +P+H AAQ RLLL + A +D + TPLH+AA VA++
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449
L+ + A PN G TPLH+A HV +++LL GA +DA + TPLH+A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509
+ +++LL+ GA P+ + PLH AA G + K LL+ A + TPLH
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
AA GH ++ LL E++AN TPLH+AAR G V ALL+ A + G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
+TPLH+A + LLE A+ +A K G TP H+A N I+K+L+ G
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 630 SPAWNGYTPLHIAAKQNQ 647
TPL +A + +
Sbjct: 720 VQDGVSCTPLQLALRSRK 737
Score = 214 bits (545), Expect = 6e-55
Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)
Query: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
++ LH +LL ++ + D + +G+TPL IAA + ++ LLL GA
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
N ++G PLH A++ G+ RLLLD GA ++ + ++ TPLH AA+N ++ +L+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
A G +P+H+AA H+ V+LL AE+D + TPLH+A G R
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
+ LL GA P++ +G+ PLH A + + ++LL+ GAS++ T G TPLH+A+
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
Query: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505
+ GHL I+ L + A+ TPLH+AAR G V LLQ A NA + T
Sbjct: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
Query: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
PLH A + V LLE++AN + G TP H+AA +G+ + L+E A
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Query: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 605
TPL +A + K + L ++ P+ A G P
Sbjct: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
Score = 211 bits (537), Expect = 5e-54
Identities = 125/372 (33%), Positives = 197/372 (52%)
Query: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
+N ++P+H ++ VRLLL ++ ++D T TPL +AA + +LL GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
N +G+ PLH A + LLL GA +DA G TPLH+A+ + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
L+ R A PN+ + +TPLH+AA GH + K L A+++A+ ++ +TPLH A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
++ LL++ A P+ +G+ PLH AA G LL AS T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
AA G + + LL E A+ A G TPLH+A H +V LL G P++ +G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
+TPLH+A +++ +LL++ + +A + G TP HLAA +G+ ++ +L+ A +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 696 LGNKSGLTPLHL 707
+ + TPL L
Sbjct: 720 VQDGVSCTPLQL 731
Score = 208 bits (530), Expect = 4e-53
Identities = 131/414 (31%), Positives = 215/414 (51%), Gaps = 29/414 (7%)
Query: 76 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135
+N + LH +G V+ V LL E+ ++ T G T L IAA Q ++ L+ +GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195
+ N + G+ PL+ AAQ + LL++GA + +G+TPL +A Q ENV
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV--- 476
Query: 196 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 255
A +L+ +P++ G TPLH+AA++ ++++
Sbjct: 477 --------------------------ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
Query: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
+LL ++GA ++ +N TPLH+A RG V ++ LL GA + + PLH AA
Sbjct: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
Query: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
G I ++LL +GA ++ T G +P+H+AA HL+ + LL + A + + + TPL
Sbjct: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
Query: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435
H+AA G V LL GA PN+ +G+TPLH+A +++ + LL+ A++ A +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
Query: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
G TP H+A+ G+ I+K L++ GA +V + TPL +A R+ + +L
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 197 bits (500), Expect = 1e-49
Identities = 135/421 (32%), Positives = 212/421 (50%), Gaps = 31/421 (7%)
Query: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205
TPL+ + +E V+ LL + + + T G+TPL +A Q ++ A L+ +G
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD--- 420
Query: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
A R D+ G+ PLH AA + A+LLL+ GA V
Sbjct: 421 -------ANRVDED-------------------GWAPLHFAAQNGDDGTARLLLDHGACV 454
Query: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
+ + G TPLH+A++ + RLL+ R A + TPLH AA GHV + ++L
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Query: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
GA + A+ +N +P+H+A + + ++ LL+ A D + PLH AA G +
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Query: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
+ K+LL GA G+TPLH+A K H+ ++ LL ++ A++ A+ TPLH+A+
Sbjct: 575 ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAA 634
Query: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505
G +V LLQ GA PN + TPLH+A + LL++ A V+A+ K T
Sbjct: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
Query: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQAC 564
P H AA G+T ++K+L+E A ++ TPL +A R + +++ LE KE S A
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVAT 753
Query: 565 M 565
+
Sbjct: 754 L 754
Score = 196 bits (497), Expect = 2e-49
Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)
Query: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
KNL+ R + KV TPLH G E + LL ++ V+ + TPL AA+
Sbjct: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
Query: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
++ LLL + A+ N G PLH AA+ G T LL+ A ++G+TPL
Sbjct: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
Query: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
H+AA+ VA LL+ R A PN G TPLHVA + ++ +VKLL +G +
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
Query: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
N TPLH+A ++ +V + LL+ G +A G PLH AA G + +LL A+
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
Query: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753
L G TPLHL A +GH+ + +L + + A + +TPLH+A+ +G +V L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 813
LQ AD NA + G++PLH A Q+ V LL++ A+ + + G TP +A G
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
Query: 814 SVTDVLKVVTDETSFVLVSD 833
T +LKV+ + + + V D
Sbjct: 705 --TAILKVLVEAGAQLDVQD 722
Score = 175 bits (443), Expect = 4e-43
Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)
Query: 56 GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 115
G++++ L + VD++ +G L +A+++ + LL + G L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 116 HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 175
H AA G D R L+++GA V+AQ ++G+TPL++AAQ N V + L+ A+ N+
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
Query: 176 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 230
+G TPL VA GH ++V L + G + +R P LH+A R LL++
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
Query: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290
PD L ++G+ PLH AA + ++LL GAS+ G TPLH+A+ +G++ ++ L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 291 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 350
L + A + TPLH AAR+G + LL GA A ++G +P+H+A Q
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
Query: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410
V LL++ A + TP H+AA G+ + KVL++ GA+ + + TPL +
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Query: 411 ACKKNHVRVMELL 423
A + +M L
Sbjct: 732 ALRSRKQGIMSFL 744
Score = 118 bits (295), Expect = 6e-26
Identities = 82/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)
Query: 42 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 101
+A+ T AA G++ G +++ +N LHLA + G V+ + LL
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 102 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
+ + + G LH AA G+ + + L+ YGA++ + +G+TPL++AA + HLE++
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 221
L E+ AN +TPL +A + G E VV
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVV---------------------------- 642
Query: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
+ LLQ +P+ ++G+TPLH+A LL A+V+ + G TP H+A+
Sbjct: 643 -SALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
Query: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
+GN ++++L++ GAQ++ + TPL A R+ I L G T G P
Sbjct: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 228 bits (580), Expect = 6e-59
Identities = 202/632 (31%), Positives = 299/632 (47%), Gaps = 51/632 (8%)
Query: 50 LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
L ++ S LD+A L +T N Q+ L A EG V V +LL + +
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
Query: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 166
T++G + L +A AG E+ + L+ ANV + KG TPL AA H+++VK LL +
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226
A+ N + G T L A G+ +VV VLL
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
Query: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 284
++ + + ++ G TPL A ++ VA+LLL GA +N T N + L +A +G+
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
Query: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
+ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA + + SP+ +
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 403
AA G H++ LL++ A ++++ + TPL AA GH + +LL +GA N++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
T L +AC + V + L+K GA I+ TPL A+ GHL +VK LL GA+
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
Query: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523
+ + +T L A GHT+VA LLQ A + +++ +TPL AAR GH V+ L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 524 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
AN N T HT L +A GH+ V LL A K G T L AAK G
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 636
V LL+ + +A +T L H N + + +++P P P N
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
Query: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
T L I K + + S L AN++ VQG
Sbjct: 770 TTLPIRNKAASKQKSSSHL----PANSQDVQG 797
Score = 224 bits (571), Expect = 6e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 288 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 338
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 397
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
Query: 398 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
Query: 458 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
Query: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 754
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 755 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
H AD + K G + L +AA+ GHT +V LL
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 221 bits (564), Expect = 4e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 763 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
Score = 219 bits (557), Expect = 3e-56
Identities = 174/509 (34%), Positives = 248/509 (48%), Gaps = 13/509 (2%)
Query: 255 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 314
A L R S Q+ L A G+V VR LL G + T++ + L A
Sbjct: 217 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS 276
Query: 315 NGHVRISEILLDHGAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 373
G+ ++++LL A ++ + K ++P+ AA G H+ V+LLL + A+++ + T
Sbjct: 277 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336
Query: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
L A G+ V KVLL+ GA NG TPL A HV V LLL+ GA I+
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396
Query: 434 T----ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 SNEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
Query: 550 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
Query: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 727
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 728 DATTRMGYTPLHVASHYGNIKLVKFLLQH 756
+ G T L A+ G+ +V +LL +
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 206 bits (525), Expect = 1e-52
Identities = 178/555 (32%), Positives = 254/555 (45%), Gaps = 38/555 (6%)
Query: 124 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
Query: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
+A G+ + L+ A+H + K TP
Sbjct: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
Query: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYD 361
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
Query: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 545 GFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
Query: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
Query: 660 ---SANAESVQGVTP 671
SA V +TP
Sbjct: 722 NLLSAPPPDVTQLTP 736
Score = 205 bits (522), Expect = 3e-52
Identities = 160/485 (32%), Positives = 241/485 (49%), Gaps = 11/485 (2%)
Query: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
S A G+++ L G +N + G + L LA G+ ++ LL +E
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 108 TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
KG+ T L AA G ++V+ L+ + A+VNAQS G T L A +++VVK LLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 221
GA+ E+G TPL A GH V L+ G + + AL +A
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
Query: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
LL+ + + + T L A ++ VA+LLL+ GA VN + +PL +A+
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
Query: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 340
G+V + LL++RGA +E + TPL AAR GH + +LL GA I A+T+ +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
+ +A G L+ L++ A DI L TPL AA GH + K LL GA ++
Sbjct: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
G T L AC+ H V ++LL+ GA ++ +E G TPL A+ GH+ V+ L+ +G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 461 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
A+ N + + T L +A GH V + LL + A + KD T L AA+ GHT++V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 520 KLLLE 524
LL+
Sbjct: 714 CYLLD 718
Score = 199 bits (506), Expect = 2e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 768 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
Score = 185 bits (470), Expect = 3e-46
Identities = 154/473 (32%), Positives = 221/473 (46%), Gaps = 36/473 (7%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + AA G++ L + D+N + G L A G+V +V L
Sbjct: 295 DRGIKGDI-TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L +E + G+T L A AG EV R L+ GA +N S + + L +A + H
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 216
LE+V+FLLE GA+Q T++ T L A GH V L++ G +V +PA
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA------- 464
Query: 217 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 276
+ +PL +AA ++ +A LL+ RGAS+ G TPL
Sbjct: 465 --------------------DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
Query: 277 HIASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKT 335
A+R G+ MV LLL +GA I +T++ + T L A G + +++ L+ GA I+
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
Query: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
+P+ AAQ HL+ V+ LL A + T T L A GH VA VLL GA
Sbjct: 565 S---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGA 621
Query: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVK 454
+ G TPL A + HV ++ L+ GA+++ T + T L +A GHL +V+
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681
Query: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
LL GA P T L AA+ GHT V YLL + + D T L
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
Score = 176 bits (446), Expect = 2e-43
Identities = 119/363 (32%), Positives = 191/363 (52%), Gaps = 45/363 (12%)
Query: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
T +TAL +A G +E+V+ L+ GA++ + +KGFTPL +AA H+ VV+ LL+N
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 167 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223
GA+ Q+ T+D TPL++A G + VV
Sbjct: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------E 1167
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 281
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227
Query: 282 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
G+ V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALT---LACFQGRTEVVSLLLDRKANVEHRAKT 1284
Query: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
Query: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
+ R G TPL +A H+ V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
Query: 456 LLQ 458
L++
Sbjct: 1405 LVK 1407
Score = 172 bits (435), Expect = 4e-42
Identities = 124/333 (37%), Positives = 173/333 (51%), Gaps = 7/333 (2%)
Query: 430 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
IDA TES T L +A GH +V+ LL+RGAS + K TPL +AA AGH V +
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134
Query: 489 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
LL N A + A++ + TPL A G +V+LLL AN + +TPL +AA G
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
Query: 548 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604
+V + LL E + +K G +PL +AA G +LLL+ + NA + N T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
Query: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 665 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
V T L +AA +GH + LL+ + A+ ++ NK G TPL L A GH+ V +L++
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
G VDA TPL A G++K+V++L++
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 168 bits (426), Expect = 4e-41
Identities = 124/362 (34%), Positives = 188/362 (51%), Gaps = 34/362 (9%)
Query: 136 NVNAQSQKGF-TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 194
+++AQ++ T L +A H E+V+ LLE GA+ + GFTPL +A GH VV
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 195 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 254
L++ G I A+++ T+ TPL +A V
Sbjct: 1134 ILLDNGAD---------IEAQSERTKD-------------------TPLSLACSGGRQEV 1165
Query: 255 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCA 312
+LLL RGA+ + TPL +A+ G V ++++LL+ GA+I ++T +L +PL A
Sbjct: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
Query: 313 ARNGHVRISEILLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
A NGH ++LLD G+ I A+ + N + + +A + V LLL A ++
Sbjct: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
Query: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGAS 429
LTPL AA G+ V +VLLDKGA N+ + T L IA K H + ELL+ GA
Sbjct: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
Query: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
ID + G TPL +A+ GHL +V+ L+Q GA + ++ + TPL A R GH +V +YL
Sbjct: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
Query: 490 LQ 491
++
Sbjct: 1406 VK 1407
Score = 167 bits (422), Expect = 1e-40
Identities = 145/483 (30%), Positives = 227/483 (46%), Gaps = 25/483 (5%)
Query: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT-------PL 276
VLL+++P ++ GF P+ A + L +A L G+ N T G+
Sbjct: 935 VLLKDEPQ-QTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQA 993
Query: 277 HIASRRGNVIMVR---LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
+A ++ L++ AQ T D++ AA +G H
Sbjct: 994 QLAGLGQGILTETQQGLMVASPAQTLNDTLDDIM----AAVSGRASAMSNTPTHSIAASI 1049
Query: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
+P + + L + + DA+ + +H T L +A GH + + LL++
Sbjct: 1050 SQPQTPTPSPIISPSAMLP-IYPAIDIDAQTES---NHDTALTLACAGGHEELVQTLLER 1105
Query: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPI 452
GA R GFTPL +A HV V+E+LL GA I+A +E + TPL +A G +
Sbjct: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165
Query: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK--AKDDQTPLHCA 510
V+ LL RGA+ NV TPL +AA G+ + K LL A++N++ +K +PL A
Sbjct: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
Query: 511 ARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
A GHT VKLLL+ ++ N T +T L +A +G E V LL+++A+ K G
Sbjct: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
Query: 570 FTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
TPL AA G V +LL++ A NA + T L +A + +LL+ RG
Sbjct: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
Query: 628 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
G TPL +AA ++V + L+Q G +A + +TPL A ++GH ++V L
Sbjct: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
Query: 688 LSK 690
+ +
Sbjct: 1406 VKE 1408
Score = 164 bits (414), Expect = 1e-39
Identities = 119/335 (35%), Positives = 171/335 (51%), Gaps = 15/335 (4%)
Query: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
+D T N L LA GH ++V LL + +E KKG T L +AA AG VV
Sbjct: 1075 IDAQT-ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 129 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
L++ GA++ AQS++ TPL +A EVV+ LL GAN+ +TPL++A
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
Query: 188 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV---LSKT 238
G+ N++ L+N G T K+ + L +AA N TAAV L D D+ +
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG--HTAAVKLLLDMGSDINAQIETN 1251
Query: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Query: 299 ETK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
T L AA GH + E+L+ GA I + K G +P+ +AA G HLD V+L
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
Query: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
L+Q A++D +TPL A GH +V + L+
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 155 bits (393), Expect = 3e-37
Identities = 135/489 (27%), Positives = 225/489 (46%), Gaps = 46/489 (9%)
Query: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
+T L +A GH E+ + LL+ A + + K TPL AA GH +V++LL+N A+
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 531 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 590 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 646
A N+ K G++PL +A + + VKLLL G ++ N T L +A Q
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 704
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
Query: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
L + A +GH ++LI G +D + G TPL +A++ G++ +V+ L+Q ADV+A
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
Query: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
+PL A ++GH +V L+K N+ SD ++ ++ +
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLVK---EVNQFPSD----------------SECMRYIAT 1424
Query: 825 ETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFK----------AERRD 874
T ++ H E++ + D E + +I+ EEL K A +R+
Sbjct: 1425 ITDKEMLKKCHLCM--ESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKRE 1482
Query: 875 SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSS 934
R K+ + KL++ I E +++ ++++ K DE ++
Sbjct: 1483 KRKEKRRKKKEEQRRKLEE---------IEAKNKENFELQAAQEKEKLKVEDEPEVLTEP 1533
Query: 935 PATETSDNI 943
P+ T+ I
Sbjct: 1534 PSATTTTTI 1542
Score = 62.8 bits (151), Expect = 3e-09
Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104
T + AA G + L G D+N + L +A+ +GH K L+ + +
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346
Query: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
+ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++ H++VV++L+
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Query: 165 E 165
+
Sbjct: 1407 K 1407
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 223 bits (569), Expect = 1e-57
Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 697 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
+ T + L GH+ V ++L+ HG + G T L A+ G+ +V +LL
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Query: 756 HQADV 760
+ +V
Sbjct: 690 YPNNV 694
Score = 222 bits (565), Expect = 3e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 559
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
A K G T L AAK G V LL+ +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
Score = 215 bits (548), Expect = 3e-55
Identities = 160/513 (31%), Positives = 259/513 (50%), Gaps = 16/513 (3%)
Query: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Query: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
Query: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
Query: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
Query: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
Query: 595 PNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
NA + T L +A ++ L+ G TPL A+++ +E+ +
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEASQEGHLELVKY 553
Query: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
LL G + +A + G T L A + GH ++ +LL A+ ++ G TPL A+ GH
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 714 VPVADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772
+ LI G V+ AT +T + +A G++ +V+ LL H AD + K G + L
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 773 QAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805
+AA+ GHT++V+ LL PN V S TT ++
Sbjct: 674 EAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
Score = 213 bits (542), Expect = 1e-54
Identities = 177/559 (31%), Positives = 261/559 (46%), Gaps = 35/559 (6%)
Query: 124 DEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
DE L A N + Q L A + + V+ LL+ G + N TE+G + L
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
+A G+ + L+ A+H D +K TP
Sbjct: 244 LACSAGYYELAQVLL-----------AMHANVE-----------------DRGNKGDITP 275
Query: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
L A+ L++ +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYD 361
++ TPL AA GHV ++ +LLDHGA I + S + +A HLD VR LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480
LL++ GA+++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
G +EVA +L++ A + TPL A++ GH +VK LL + AN + T G T L
Sbjct: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599
A GH + LL+ A ++ G TPL AA+ G + + L+ + A+ N A
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
N T + +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
Query: 660 SANAESVQGVTPLHLAAQE 678
+ + V+ L +Q+
Sbjct: 693 NVLSVPTTDVSQLPPPSQD 711
Score = 207 bits (528), Expect = 6e-53
Identities = 161/478 (33%), Positives = 239/478 (50%), Gaps = 8/478 (1%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 761
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
A ++ + A GH +V LLL +GA P DG+T L A + G+ +V L
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 198 bits (504), Expect = 4e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 491
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 180 bits (457), Expect = 1e-44
Identities = 143/429 (33%), Positives = 214/429 (49%), Gaps = 15/429 (3%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + A+ G LD L + D+N+ + G L A G V +V L
Sbjct: 266 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L++ +E + G+T L AA AG EV R L+++GA +N S + + L +A + H
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
L++V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 442
Query: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
+AA AA+L++ N + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+ T L +A G + L+ GA IE TPL A++ GH+ + + LL GA
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
+ A T G + + A + H D +LLQ A+++ + TPL AA GH +
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
Query: 390 LLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448
L+ KGA N + A N T + +AC H+ V+ELLL GA + G T L A+ G
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
Query: 449 HLPIVKNLL 457
H +V LL
Sbjct: 680 HTNVVSYLL 688
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
Query: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 346 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 157 bits (396), Expect = 1e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 430 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 489 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 548 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 665 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
G VDA TPL A G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 157 bits (396), Expect = 1e-37
Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)
Query: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
+H T L +A GH + VL+ + AK R GFTPL +A HV V+E+LL G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 430 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
I+A +E + TPL +A G +V LL RGA+ NV TPL +AA G+ + K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 489 LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 545
LL A++N++ +K +PL AA GH VKLLL+ ++ N T +T L +A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 546 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 603
+G E V LL+++A+ K G TPL AA G V +LL++ A NA +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
T L +A + +LL+ RG G TPL +A+ +V + L+Q G +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 664 ESVQGVTPLHLAAQEGHAEMVALLLSK 690
+ +TPL A ++GH ++V L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 155 bits (393), Expect = 3e-37
Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)
Query: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
+D +T N L LA GH ++V L+ ++ +E KKG T L +AA AG VV
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 129 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
L++ G ++ AQS++ TPL +A EVV LL GAN+ +TPL++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 188 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 239
G+ N++ L+N G T K+ + L +AA N +LL +D N + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 240 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 300 TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
T L AA GH + E+L+ GA I + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 417
+Q A++D +TPL A GH +V + L+ + +N F P I C +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395
Query: 418 RV--MELLLKTGASIDAVTES 436
+ ELL K ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416
Score = 155 bits (393), Expect = 3e-37
Identities = 141/495 (28%), Positives = 231/495 (46%), Gaps = 45/495 (9%)
Query: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 531 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 590 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 646
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 704
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
+PL A ++GH +V L+K N+ SD I + +TD
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD-------------IECMRYIATITD 1399
Query: 825 ETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFK----------AERRD 874
+ L+ H+ ET+ + D E + +I+ +EL K A +R+
Sbjct: 1400 KE---LLKKCHQC--VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKRE 1454
Query: 875 SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PS 933
R +K+ + K ++ E+ P+ +PE E++E+ ++ +++ I P
Sbjct: 1455 KRKEKRKKKKEEQKRKQEEDEENK--PKENSELPE-----DEDEEENDEDVEQEVPIEPP 1507
Query: 934 SPATETSDNISPVAS 948
S T T+ IS ++
Sbjct: 1508 SATTTTTIGISATSA 1522
Score = 155 bits (392), Expect = 4e-37
Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 267
AL +A +VL+ D + K GFTPL +AA ++ V ++LL++G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
+ + TPL +A G +V LLL RGA E + + TPL AA G+V I +ILL+
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 328 GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 362
GA I ++T K G+SP+ +AA H+ V+LLL Q A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 363 EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 409
E+ + LD LTPL AA G+ V +VLLDKGA N+ + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
IA K H + ELL+ GA ID + G TPL +AS GH +V+ L+Q GA + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 470 VETPLHMAARAGHTEVAKYLLQ 491
TPL A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
Score = 141 bits (355), Expect = 7e-33
Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)
Query: 484 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
E A L + KA+ + A D L A G N V+ LL+ + N T G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 543 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 601
A G+ E LL A+ KG TPL A+ G + + +LLL DA N+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
G T L A +DIVK+LL G + NG+TPL AA VEVAR LL +G
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 662 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 687
N S + T L A +GH E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
L A N+ S +PL L A GHV +A +LI+ G ++ GYTPL A+ G+
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484
Query: 748 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 776
++V LL A++NA+T +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544
Query: 777 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
+GH ++V LL +GA+ + ++ G T L A G+ V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 121 bits (303), Expect = 7e-27
Identities = 99/297 (33%), Positives = 149/297 (50%), Gaps = 10/297 (3%)
Query: 38 DRKKKADAA-TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96
D++ K D T+ + A G+++ A L +G +N + + L LA+ GHV++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQEN 155
L+ + LE +G T L AA G +E+V L+ GAN+NAQ+++ T L +A
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL----PALH 211
EV FL++ GA+ + TPL A Q+GH +V +L+ G AL
Sbjct: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN-FTPQ 270
A N T A VLLQ + + S+ G TPL AA +L Q L+++GA+VN T
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
Query: 271 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
N T + +A G++ +V LLL GA + KD T L AA+ GH + LLD+
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 65.5 bits (158), Expect = 5e-10
Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 2/121 (1%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104
T + AA G + L G D+N + L +A+ +GH K L+H+ +
Sbjct: 1259 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHI 1318
Query: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
+ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++ H++VV++L+
Sbjct: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Query: 165 E 165
+
Sbjct: 1379 K 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 223 bits (569), Expect = 1e-57
Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 697 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
+ T + L GH+ V ++L+ HG + G T L A+ G+ +V +LL
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Query: 756 HQADV 760
+ +V
Sbjct: 690 YPNNV 694
Score = 222 bits (565), Expect = 3e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 559
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
A K G T L AAK G V LL+ +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
Score = 215 bits (548), Expect = 3e-55
Identities = 160/513 (31%), Positives = 259/513 (50%), Gaps = 16/513 (3%)
Query: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Query: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
Query: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
Query: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
Query: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
Query: 595 PNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
NA + T L +A ++ L+ G TPL A+++ +E+ +
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEASQEGHLELVKY 553
Query: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
LL G + +A + G T L A + GH ++ +LL A+ ++ G TPL A+ GH
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 714 VPVADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772
+ LI G V+ AT +T + +A G++ +V+ LL H AD + K G + L
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 773 QAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805
+AA+ GHT++V+ LL PN V S TT ++
Sbjct: 674 EAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
Score = 213 bits (542), Expect = 1e-54
Identities = 177/559 (31%), Positives = 261/559 (46%), Gaps = 35/559 (6%)
Query: 124 DEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
DE L A N + Q L A + + V+ LL+ G + N TE+G + L
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
+A G+ + L+ A+H D +K TP
Sbjct: 244 LACSAGYYELAQVLL-----------AMHANVE-----------------DRGNKGDITP 275
Query: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
L A+ L++ +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYD 361
++ TPL AA GHV ++ +LLDHGA I + S + +A HLD VR LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480
LL++ GA+++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
G +EVA +L++ A + TPL A++ GH +VK LL + AN + T G T L
Sbjct: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599
A GH + LL+ A ++ G TPL AA+ G + + L+ + A+ N A
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
N T + +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
Query: 660 SANAESVQGVTPLHLAAQE 678
+ + V+ L +Q+
Sbjct: 693 NVLSVPTTDVSQLPPPSQD 711
Score = 207 bits (528), Expect = 6e-53
Identities = 161/478 (33%), Positives = 239/478 (50%), Gaps = 8/478 (1%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 761
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
A ++ + A GH +V LLL +GA P DG+T L A + G+ +V L
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 198 bits (504), Expect = 4e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 491
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 180 bits (457), Expect = 1e-44
Identities = 143/429 (33%), Positives = 214/429 (49%), Gaps = 15/429 (3%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + A+ G LD L + D+N+ + G L A G V +V L
Sbjct: 266 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L++ +E + G+T L AA AG EV R L+++GA +N S + + L +A + H
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
L++V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 442
Query: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
+AA AA+L++ N + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+ T L +A G + L+ GA IE TPL A++ GH+ + + LL GA
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
+ A T G + + A + H D +LLQ A+++ + TPL AA GH +
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
Query: 390 LLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448
L+ KGA N + A N T + +AC H+ V+ELLL GA + G T L A+ G
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
Query: 449 HLPIVKNLL 457
H +V LL
Sbjct: 680 HTNVVSYLL 688
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
Query: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 346 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 157 bits (396), Expect = 1e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 430 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 489 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 548 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 665 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
G VDA TPL A G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 157 bits (396), Expect = 1e-37
Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)
Query: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
+H T L +A GH + VL+ + AK R GFTPL +A HV V+E+LL G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 430 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
I+A +E + TPL +A G +V LL RGA+ NV TPL +AA G+ + K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 489 LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 545
LL A++N++ +K +PL AA GH VKLLL+ ++ N T +T L +A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 546 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 603
+G E V LL+++A+ K G TPL AA G V +LL++ A NA +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
T L +A + +LL+ RG G TPL +A+ +V + L+Q G +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 664 ESVQGVTPLHLAAQEGHAEMVALLLSK 690
+ +TPL A ++GH ++V L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 155 bits (393), Expect = 3e-37
Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)
Query: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
+D +T N L LA GH ++V L+ ++ +E KKG T L +AA AG VV
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 129 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
L++ G ++ AQS++ TPL +A EVV LL GAN+ +TPL++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 188 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 239
G+ N++ L+N G T K+ + L +AA N +LL +D N + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 240 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 300 TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
T L AA GH + E+L+ GA I + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 417
+Q A++D +TPL A GH +V + L+ + +N F P I C +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395
Query: 418 RV--MELLLKTGASIDAVTES 436
+ ELL K ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416
Score = 155 bits (393), Expect = 3e-37
Identities = 141/495 (28%), Positives = 231/495 (46%), Gaps = 45/495 (9%)
Query: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 531 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 590 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 646
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 704
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
+PL A ++GH +V L+K N+ SD I + +TD
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD-------------IECMRYIATITD 1399
Query: 825 ETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFK----------AERRD 874
+ L+ H+ ET+ + D E + +I+ +EL K A +R+
Sbjct: 1400 KE---LLKKCHQC--VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKRE 1454
Query: 875 SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PS 933
R +K+ + K ++ E+ P+ +PE E++E+ ++ +++ I P
Sbjct: 1455 KRKEKRKKKKEEQKRKQEEDEENK--PKENSELPE-----DEDEEENDEDVEQEVPIEPP 1507
Query: 934 SPATETSDNISPVAS 948
S T T+ IS ++
Sbjct: 1508 SATTTTTIGISATSA 1522
Score = 155 bits (392), Expect = 4e-37
Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)
Query: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 267
AL +A +VL+ D + K GFTPL +AA ++ V ++LL++G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
+ + TPL +A G +V LLL RGA E + + TPL AA G+V I +ILL+
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 328 GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 362
GA I ++T K G+SP+ +AA H+ V+LLL Q A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 363 EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 409
E+ + LD LTPL AA G+ V +VLLDKGA N+ + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
IA K H + ELL+ GA ID + G TPL +AS GH +V+ L+Q GA + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 470 VETPLHMAARAGHTEVAKYLLQ 491
TPL A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
Score = 141 bits (355), Expect = 7e-33
Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)
Query: 484 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
E A L + KA+ + A D L A G N V+ LL+ + N T G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 543 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 601
A G+ E LL A+ KG TPL A+ G + + +LLL DA N+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
G T L A +DIVK+LL G + NG+TPL AA VEVAR LL +G
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 662 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 687
N S + T L A +GH E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
L A N+ S +PL L A GHV +A +LI+ G ++ GYTPL A+ G+
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484
Query: 748 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 776
++V LL A++NA+T +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544
Query: 777 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
+GH ++V LL +GA+ + ++ G T L A G+ V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 121 bits (303), Expect = 7e-27
Identities = 99/297 (33%), Positives = 149/297 (50%), Gaps = 10/297 (3%)
Query: 38 DRKKKADAA-TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96
D++ K D T+ + A G+++ A L +G +N + + L LA+ GHV++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQEN 155
L+ + LE +G T L AA G +E+V L+ GAN+NAQ+++ T L +A
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL----PALH 211
EV FL++ GA+ + TPL A Q+GH +V +L+ G AL
Sbjct: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN-FTPQ 270
A N T A VLLQ + + S+ G TPL AA +L Q L+++GA+VN T
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
Query: 271 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
N T + +A G++ +V LLL GA + KD T L AA+ GH + LLD+
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 65.5 bits (158), Expect = 5e-10
Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 2/121 (1%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104
T + AA G + L G D+N + L +A+ +GH K L+H+ +
Sbjct: 1259 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHI 1318
Query: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
+ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++ H++VV++L+
Sbjct: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Query: 165 E 165
+
Sbjct: 1379 K 1379
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 199 bits (507), Expect = 2e-50
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 224
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 225 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 278
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
Query: 279 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 336
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 394
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 395 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 454
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 572
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 573 LHVAAKYGKVRVAELLLERDAHPNAA 598
L A + V + +LE A AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
Score = 191 bits (485), Expect = 6e-48
Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)
Query: 115 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 173
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 174 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 227
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 284
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 285 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 340
V VR +LD + + + + TPLH A +G+V + ++L + I + +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 398
P+H AA H V LLL+ + I D TPLH AA KV L + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 399 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
L G T A K V+ L LK+ I+ + G T LH A+ GH+ VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
L+ A + ++V TPL A GH +V + L++ A+V+ +D + LH AA G+
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
++ ++L+EN NPN+ AG TPL AA G++ + L+E A K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 577 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 625
G + +LLL+ A PN N TPL A+ ++++ +L G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 183 bits (465), Expect = 1e-45
Identities = 144/516 (27%), Positives = 245/516 (47%), Gaps = 19/516 (3%)
Query: 309 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 367
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 428 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 480
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 481 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 536
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 537 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 595
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 653
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
Query: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
Query: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 773
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
Query: 774 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA 807
+ G+ D + LLL A PN++ + + TPL A
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
Score = 170 bits (430), Expect = 1e-41
Identities = 144/501 (28%), Positives = 227/501 (45%), Gaps = 51/501 (10%)
Query: 375 LHVAAHCGHH-RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
+H AA G + ++++ A + G TPL + + + LLK GA ++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
S T LH+A+ G+ +K LL R A+ +++ TPLH+ R + LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 494 A--KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE---GH 548
A +V+ + K+ QT LH +A + VKLL+++++N + G PLH AA
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 549 VETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-- 603
V TV +L+ +++ + +G TPLH A G V V ++L ++ N + L
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC-NITSYDNLFR 256
Query: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG--- 659
TPLH A + IV LLL R S P+ + G TPLH AA+ N E + L++
Sbjct: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 660 --------------------------------SANAESVQGVTPLHLAAQEGHAEMVALL 687
N G T LH AA GH V LL
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
L A + + TPL + GH V LIK G VD + G++ LH A+ GN
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
+ + L++++ + N + G +PL AA G+ + + +L++N A PN +G T L +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 808 KRLGYISVTDVLKVVTDETSF 828
GY+ D +K++ D +F
Sbjct: 497 CNNGYL---DAIKLLLDFAAF 514
Score = 167 bits (423), Expect = 9e-41
Identities = 142/520 (27%), Positives = 234/520 (45%), Gaps = 20/520 (3%)
Query: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
+L++ A + Q G TPL + LL GA + + T LH AA+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 373
G+ R ++LL A K ++P+H+ + C+ LLL++ A E+D + T
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH--------VRVMELLLK 425
LH +A+ + K+L+ + + G PLH A NH VR +
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAP 209
Query: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK--VETPLHMAARAGHT 483
T + ++ G TPLH A G++ +V ++L S N+++ TPLH AA GH
Sbjct: 210 TESLLNWQDYEGRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGHA 268
Query: 484 EVAKYLLQ-NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
++ LL+ NK+ TPLH AA+ VK+ L++ + + + G T
Sbjct: 269 QIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMW 328
Query: 543 AAREGHVETVLALL--EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
AA +G + + +L + + K G T LH AA G V +LLLE +A +A
Sbjct: 329 AAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV 388
Query: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
TPL A + D+++ L+ G +G++ LH AA +V + L++ +
Sbjct: 389 MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN 448
Query: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
N + G TPL AA G+ +A+L+ A+ N+ +K G T LH G++ +L
Sbjct: 449 PNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
Query: 721 IKHGVMVDA--TTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
+ + YTPL A ++++F+L+H A
Sbjct: 509 LDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 167 bits (422), Expect = 1e-40
Identities = 147/542 (27%), Positives = 239/542 (44%), Gaps = 45/542 (8%)
Query: 34 NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93
N + K+ T + + LD A L+ G D+N + + LHLA+++G+ +
Sbjct: 37 NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRF 96
Query: 94 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMA 151
+ LL + + T LH+ + + L+ + A V+ Q + T L+ +
Sbjct: 97 MKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWS 156
Query: 152 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 211
A N+ E VK L+++ +N + +G P LH
Sbjct: 157 AYYNNPEHVKLLIKHDSNIGIPDVEGKIP-----------------------------LH 187
Query: 212 IAARNDD---TRTAAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASV 265
AA + D T +L P +L+ G TPLH A N+ V +L + S
Sbjct: 188 WAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESC 246
Query: 266 NFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISE 322
N T + + TPLH A+ G+ +V LLL+R + + TPLH AA++ +
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
Query: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAH 380
+ L H + G + AA D +R +L ++ID D T LH AA
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366
Query: 381 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH K+LL+ A+ ++ + TPL AC+ H V++ L+K GA +D V + G +
Sbjct: 367 SGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL 426
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
LH A+ G+ + + L++ +PNV + TPL AA G+ L++N A N +
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEK 558
K+ +T LH + G+ + +KLLL+ A PN +TPL A E + +LE
Sbjct: 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH 546
Query: 559 EA 560
A
Sbjct: 547 GA 548
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 199 bits (507), Expect = 2e-50
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 224
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 225 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 278
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
Query: 279 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 336
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 394
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 395 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 454
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 572
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 573 LHVAAKYGKVRVAELLLERDAHPNAA 598
L A + V + +LE A AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
Score = 191 bits (485), Expect = 6e-48
Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)
Query: 115 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 173
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 174 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 227
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 284
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 285 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 340
V VR +LD + + + + TPLH A +G+V + ++L + I + +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 398
P+H AA H V LLL+ + I D TPLH AA KV L + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 399 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
L G T A K V+ L LK+ I+ + G T LH A+ GH+ VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
L+ A + ++V TPL A GH +V + L++ A+V+ +D + LH AA G+
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
++ ++L+EN NPN+ AG TPL AA G++ + L+E A K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 577 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 625
G + +LLL+ A PN N TPL A+ ++++ +L G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 183 bits (465), Expect = 1e-45
Identities = 144/516 (27%), Positives = 245/516 (47%), Gaps = 19/516 (3%)
Query: 309 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 367
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 428 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 480
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 481 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 536
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 537 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 595
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 653
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
Query: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
Query: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 773
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
Query: 774 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA 807
+ G+ D + LLL A PN++ + + TPL A
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
Score = 170 bits (430), Expect = 1e-41
Identities = 144/501 (28%), Positives = 227/501 (45%), Gaps = 51/501 (10%)
Query: 375 LHVAAHCGHH-RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
+H AA G + ++++ A + G TPL + + + LLK GA ++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
S T LH+A+ G+ +K LL R A+ +++ TPLH+ R + LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 494 A--KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE---GH 548
A +V+ + K+ QT LH +A + VKLL+++++N + G PLH AA
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 549 VETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL-- 603
V TV +L+ +++ + +G TPLH A G V V ++L ++ N + L
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC-NITSYDNLFR 256
Query: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG--- 659
TPLH A + IV LLL R S P+ + G TPLH AA+ N E + L++
Sbjct: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 660 --------------------------------SANAESVQGVTPLHLAAQEGHAEMVALL 687
N G T LH AA GH V LL
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
L A + + TPL + GH V LIK G VD + G++ LH A+ GN
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
+ + L++++ + N + G +PL AA G+ + + +L++N A PN +G T L +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 808 KRLGYISVTDVLKVVTDETSF 828
GY+ D +K++ D +F
Sbjct: 497 CNNGYL---DAIKLLLDFAAF 514
Score = 167 bits (423), Expect = 9e-41
Identities = 142/520 (27%), Positives = 234/520 (45%), Gaps = 20/520 (3%)
Query: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
+L++ A + Q G TPL + LL GA + + T LH AA+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA--EIDDITLDHLT 373
G+ R ++LL A K ++P+H+ + C+ LLL++ A E+D + T
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH--------VRVMELLLK 425
LH +A+ + K+L+ + + G PLH A NH VR +
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAP 209
Query: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK--VETPLHMAARAGHT 483
T + ++ G TPLH A G++ +V ++L S N+++ TPLH AA GH
Sbjct: 210 TESLLNWQDYEGRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGHA 268
Query: 484 EVAKYLLQ-NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
++ LL+ NK+ TPLH AA+ VK+ L++ + + + G T
Sbjct: 269 QIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMW 328
Query: 543 AAREGHVETVLALL--EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
AA +G + + +L + + K G T LH AA G V +LLLE +A +A
Sbjct: 329 AAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV 388
Query: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
TPL A + D+++ L+ G +G++ LH AA +V + L++ +
Sbjct: 389 MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKIN 448
Query: 661 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
N + G TPL AA G+ +A+L+ A+ N+ +K G T LH G++ +L
Sbjct: 449 PNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508
Query: 721 IKHGVMVDA--TTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
+ + YTPL A ++++F+L+H A
Sbjct: 509 LDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 167 bits (422), Expect = 1e-40
Identities = 147/542 (27%), Positives = 239/542 (44%), Gaps = 45/542 (8%)
Query: 34 NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93
N + K+ T + + LD A L+ G D+N + + LHLA+++G+ +
Sbjct: 37 NSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRF 96
Query: 94 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMA 151
+ LL + + T LH+ + + L+ + A V+ Q + T L+ +
Sbjct: 97 MKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWS 156
Query: 152 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 211
A N+ E VK L+++ +N + +G P LH
Sbjct: 157 AYYNNPEHVKLLIKHDSNIGIPDVEGKIP-----------------------------LH 187
Query: 212 IAARNDD---TRTAAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASV 265
AA + D T +L P +L+ G TPLH A N+ V +L + S
Sbjct: 188 WAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESC 246
Query: 266 NFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISE 322
N T + + TPLH A+ G+ +V LLL+R + + TPLH AA++ +
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
Query: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAH 380
+ L H + G + AA D +R +L ++ID D T LH AA
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAAL 366
Query: 381 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH K+LL+ A+ ++ + TPL AC+ H V++ L+K GA +D V + G +
Sbjct: 367 SGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSL 426
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
LH A+ G+ + + L++ +PNV + TPL AA G+ L++N A N +
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEK 558
K+ +T LH + G+ + +KLLL+ A PN +TPL A E + +LE
Sbjct: 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH 546
Query: 559 EA 560
A
Sbjct: 547 GA 548
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 197 bits (502), Expect = 6e-50
Identities = 221/817 (27%), Positives = 338/817 (41%), Gaps = 85/817 (10%)
Query: 71 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
Query: 131 VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 178
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
Query: 179 TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL-LQNDPNPDVLSK 237
TPL V++ G+E V + L+ + L + ++ + TA L +Q+ S
Sbjct: 369 TPLHVSIMAGNEYVFSQLL--------QCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
Query: 238 TGF--TPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIMVRLLLDR 294
F P+ ++ + A L+ RG+ + G L A+ GN L
Sbjct: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480
Query: 295 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL--------------- 339
GA + + K TPLH A R+G ++ LL GA +T+ L
Sbjct: 481 GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540
Query: 340 ----SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPLHVAAHCG 382
+P+HMA +H D V ++L+ A I D +L T L +A G
Sbjct: 541 VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600
Query: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPL 441
H +A LL GA N +G T LH+A ++ + LL+ A I+ T+ G T L
Sbjct: 601 MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660
Query: 442 HVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
+A LP+V + + RGA +V + K PL +A ++A L+++
Sbjct: 661 QLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWG 719
Query: 501 KDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------HTPLHIAA 544
QT LH A + L+ + + N G TPLH+AA
Sbjct: 720 PGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAA 779
Query: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGL 603
G ETV LLE A+ +G TP+HVA + +LL+ D H N + GL
Sbjct: 780 SWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGL 839
Query: 604 TPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
TP A+ N + +L R G+ G LH+A + + +E L+ + N
Sbjct: 840 TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899
Query: 663 A--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
+ + +TPLHLA Q G +V LL A N K T LHL AQ+ + VL
Sbjct: 900 SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Query: 721 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGH 779
+++GV A G LH+A +G + ++ LL + D A G SPLH Q G
Sbjct: 960 LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019
Query: 780 TD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 811
+ I L L+ G ++ +DG+T L +A G
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
Score = 185 bits (469), Expect = 4e-46
Identities = 206/750 (27%), Positives = 310/750 (41%), Gaps = 88/750 (11%)
Query: 147 PLYMAAQENHLEVVKFLLENGANQ-----NVATEDGFTPLAVALQQGHENV----VAHLI 197
PL+ A + +VV L +Q N A +G L +AL + E++ V+H
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
Query: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--NPDVLSKTGFTPLHIAAHY------ 249
+ K LH + D A L++N N L TPLH+ A Y
Sbjct: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE-TPLHLVALYSSKKHS 339
Query: 250 -----ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN-VIMVRLLLDRGAQIETKTK 303
E +A+ LL GA+ N G TPLH++ GN + +LL + +E K
Sbjct: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
Query: 304 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
+ T L A + H+ +S Q+ P+ D L+Q +
Sbjct: 400 EGSTALWLAVQ--HITVSSD--------QSVNPFEDVPVVNGTSFDENSFAARLIQRGSH 449
Query: 364 ID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 422
D T L AA G+ A L GA N R G TPLH AC+ +
Sbjct: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509
Query: 423 LLKTGASIDAVTESGL-------------------TPLHVASFMGHLPIVKNLLQRGASP 463
LL+ GA+ + TE L TPLH+A H +V +L++ A+
Sbjct: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569
Query: 464 -------------NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510
++ + + +T L +A G +A LL + A +N D QT LH A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
Query: 511 ARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
+ + LLE+ A+ N++ T G T L +A R V A+ + A + +KG
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
Query: 570 FTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 625
PL +A +A L+ DA G G T LH A+ NN L+ G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
Query: 626 ---GSPHSPAWNG---------YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 673
SP P NG TPLH+AA E + LL++G + NA+ +G TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
Query: 674 LAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATT 731
+A H ++ LL+S + N+ ++ GLTP + A+ ++K +
Sbjct: 810 VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
Query: 732 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGYSPLHQAAQQGHTDIVTLLLKN 789
G LHVA +I+ V FL+ A+VN++ + +PLH A Q G IV LL
Sbjct: 870 NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
Query: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
GA NE++ T L +A + ++ VL
Sbjct: 930 GAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Score = 152 bits (385), Expect = 2e-36
Identities = 164/638 (25%), Positives = 261/638 (40%), Gaps = 58/638 (9%)
Query: 32 RRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV 91
+R D A RAA +GN AL NG +N N+ G LH A + G
Sbjct: 445 QRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLA 504
Query: 92 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 151
+ ELL + N L + L + +V+ Q TPL+MA
Sbjct: 505 NLTAELLQ---------QGANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMA 550
Query: 152 AQENHLEVVKFLLENGANQNVATED-------------GFTPLAVALQQGHENVVAHLIN 198
NH +VV +LE AN AT + T L +AL G + A L+
Sbjct: 551 IAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLG 610
Query: 199 YGTKGKVRL----PALHIAARNDDTRTAAVLLQNDPNPDV-LSKTGFTPLHIAAHYENLN 253
G + LH+A + D+++A LL++ + +V ++ G T L +A +
Sbjct: 611 SGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPL 670
Query: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPL 309
V + RGA ++ + G PL +A + L+ G T L
Sbjct: 671 VVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLL 730
Query: 310 HCAARNGHVRISEILLDHGAPI------------QAKTKNGLSPIHMAAQGDHLDCVRLL 357
H A + + L+ G + + + ++G +P+H+AA + V+ L
Sbjct: 731 HRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCL 790
Query: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACK-KN 415
L++ A ++ + TP+HVA H + ++L+ N R G TP A KN
Sbjct: 791 LEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKN 850
Query: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETP 473
+ +L + + + V G LHVA + V L+ A+ N V + TP
Sbjct: 851 NKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTP 910
Query: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
LH+A +AG + + LL AKVN K QT LH AA+ + +LLEN +
Sbjct: 911 LHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVD 970
Query: 534 TAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLL 589
G+ LH+A G + + LL E +G +PLH+ +YGK A +L L
Sbjct: 971 ENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFL 1030
Query: 590 E-RDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
E +P + +G T L +A N ++ + ++ G
Sbjct: 1031 ECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSG 1068
Score = 144 bits (364), Expect = 6e-34
Identities = 128/487 (26%), Positives = 216/487 (44%), Gaps = 33/487 (6%)
Query: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQ 140
L LA G + +LL + T G T LH+A + L+ + A++N ++
Sbjct: 593 LGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSR 652
Query: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
+Q G T L +A + VV + GA+ +V E G PL +AL E++ + L+ +G
Sbjct: 653 TQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
Query: 201 TKGKVRLPA--------LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGF 240
P LH A ++ TA L++ N P + ++ G
Sbjct: 713 CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
Query: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIE 299
TPLH+AA + Q LL GA+VN G TP+H+A + ++++LL+ +
Sbjct: 773 TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
Query: 300 TKTKDELTPLHCAARNGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
+ + LTP CA + + +E +L + GA Q K G + +H+A Q ++ V L
Sbjct: 833 VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFL 891
Query: 358 LQYDAEIDDITLD--HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
+ A ++ D LTPLH+A G + + LL GAK N + T LH+A +++
Sbjct: 892 ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQD 951
Query: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPL 474
+ +LL+ G AV E+G LH+A G L ++ LL + N++ ++PL
Sbjct: 952 LPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPL 1011
Query: 475 HMAARAGHTEVAKYL-----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
H+ + G A ++ D T L A G+ N+ + ++ + A
Sbjct: 1012 HILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARL 1071
Query: 530 NLATTAG 536
+ G
Sbjct: 1072 GVNNNQG 1078
Score = 114 bits (285), Expect = 9e-25
Identities = 95/360 (26%), Positives = 161/360 (44%), Gaps = 42/360 (11%)
Query: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGF------------TPLYMAAQENHLEVV 160
T LH A + L+ G +VN+ Q G TPL++AA E V
Sbjct: 728 TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
Query: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
+ LLE GAN N +G TP+ VA+ H ++ L+++ P +H+ R+
Sbjct: 788 QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH--------PDIHLNVRDRQGL 839
Query: 221 T---AAVLLQNDPNPDVLSKT-----------GFTPLHIAAHYENLNVAQLLLNRGASVN 266
T A+ +N+ + + + K G LH+A ++ L++ A+VN
Sbjct: 840 TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899
Query: 267 FTPQNG--ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Q+ +TPLH+A + G+ I+VR LL GA++ TK T LH AA+ I +L
Sbjct: 900 SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Query: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGH 383
L++G A +NG + +H+A L+ +R+LL + + + L +PLH+ G
Sbjct: 960 LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019
Query: 384 HRVAKVL-----LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438
A + G + +G T L +A K + + ++++GA + G+
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
Score = 47.4 bits (111), Expect = 1e-04
Identities = 41/170 (24%), Positives = 75/170 (44%), Gaps = 6/170 (3%)
Query: 39 RKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 98
R + A T A ++G+ + L G +N ++ LHLA+++ + LL
Sbjct: 901 RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLL 960
Query: 99 HKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQ---E 154
+ + GN ALH+A + G+ +R L+ + A + +G +PL++ Q E
Sbjct: 961 ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKE 1020
Query: 155 NHLEVVKFLLE--NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 202
N + LE G + DG T L +A +G+ N+ ++ G +
Sbjct: 1021 NAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGAR 1070
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 196 bits (498), Expect = 2e-49
Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)
Query: 225 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 284
LL+ + D ++ G TPL IAA NL + + L+ GA+ N + T L AS+ G+
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
Query: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
V +V LL G +E + T L A G + E+LL HGA + PI
Sbjct: 84 VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
Query: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
AA H D V LLLQ A+++ TPL AA GH K LL GA + N
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
T L +A K + + ++ +LK +++ + G T L +AS GH IV++LL G N
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
+ + +T L A R GH E+ + LLQ A ++ + +D++T L+ A G+ MV+ +L+
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
Query: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
N + + T G TPL A + ++E V LL+K A + + KKG TPLH+A + ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
Query: 585 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
AELLL PN AG+ TP ++ H + ++ R SP
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
Score = 185 bits (469), Expect = 4e-46
Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)
Query: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
EN+ + LL + V+ + G TPL IA+ +GN+ +V+ L+ GA + D T L
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369
A++ GHV I E LL G ++ + G + + A D V LLL + A L
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
+ P+ AA GH + +LL GAK N G TPL A +K H+ ++ LL GA
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
+D + +T L VA G+ VK +L+R + N+++ T L +A++ GHTE+ + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
L VN + T L A R GH +V+ LL+ A+ ++ T L+ A +G+
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
V +L+ TK G TPL A K + V ELLL++ A +A K G TPLH+A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Query: 610 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 641
+ + + +LLL P+ G + P G TP +I
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 182 bits (463), Expect = 2e-45
Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)
Query: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383
LL+ + + + G +P+ +AA+ +L+ V+ L++ A + LD+ T L A+ GH
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
Query: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443
+ + LL G R + G+T L AC K V+ELLL GA+ + P+
Sbjct: 84 VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
Query: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
A+ GH IV LLQ GA N S+ TPL AAR GH E K+LL A V+ + +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
T L A + G+T VK +L+ N N NL G+T L IA++EGH E V LL+
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
+ G T L A + G V + LL++ A + G++ T L+ AV N +V+ +L
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
Query: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
+G TPL A K +EV LL G +A +G TPLH+A + ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
Query: 684 VALLLSKQANGNL---GNKSGLTPLHL 707
LLL +G L NK+G TP ++
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 178 bits (451), Expect = 5e-44
Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)
Query: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 408
+++ ++ LL+ ++D+ TPL +AA G+ + K L+ GA N L+ +T L
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 409 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 468
A K+ HV ++E LLK G +++ G T L A + G +V+ LL GA+P+V+ +
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
P+ AA GH ++ LLQN AKVN K TPL AAR GH VK LL A+
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
+ T L +A + G+ ++V +L++ + K G T L +A+K G + + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
L+ + N ++G T L AV +++IV+ LL + + T L+ A ++
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
+ R +LQ + G TPL A + + E+V LLL K A + +K G TPLH+
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Query: 709 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 756
+ +A++L+ K G ++ + G TP ++ SH +I F +H
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
Score = 172 bits (437), Expect = 2e-42
Identities = 119/377 (31%), Positives = 190/377 (50%)
Query: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472
++ ++ ++ LL+ +D E G TPL +A+ G+L IVK L++ GA+ N+ ++ T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532
L A++ GH + + LL+ + + T L A G T++V+LLL + ANP++
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
P+ AA GH + V LL+ A C K G TPL AA+ G + + LL
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 593 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 652
A + G N +T L VAV VK +L R + + +G T L IA+K+ E+ +
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 712
LL G N G T L A + GH E+V LL K A+ ++ + T L+ ++G
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
Query: 713 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772
+ + +++ + T+ G TPL A+ NI++V+ LL A V+A K G +PLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
Query: 773 QAAQQGHTDIVTLLLKN 789
A + + LLL+N
Sbjct: 374 IAIRGRSRKLAELLLRN 390
Score = 172 bits (437), Expect = 2e-42
Identities = 126/419 (30%), Positives = 204/419 (48%), Gaps = 32/419 (7%)
Query: 127 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 186
++ L+ +V+ +++ G TPL +AA++ +LE+VK L++NGAN N+ D +T L A +
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 187 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246
+GH ++V L+ G N + G+T L A
Sbjct: 81 EGHVHIVEELLKCGV-----------------------------NLEHRDMGGWTALMWA 111
Query: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306
+ +V +LLL+ GA+ + T + P+ A+ RG+ +V LLL GA++ K
Sbjct: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171
Query: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
TPL AAR GH+ + LL GA + + N ++ + +A +G + V+ +L+ + ++
Sbjct: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231
Query: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
D T L +A+ GH + + LLD G N +G T L A + HV ++ LL+
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Query: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486
A ID + T L+ A G+ +V+++LQ + ETPL A + + EV
Sbjct: 292 YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351
Query: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL---ATTAGHTPLHI 542
+ LL AKV+A K TPLH A R + +LLL N + L AG TP +I
Sbjct: 352 ELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 172 bits (435), Expect = 4e-42
Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)
Query: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
T + AA GNL+ + ++NG + N + + L ASKEGHV +V ELL + LE
Sbjct: 40 TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
Query: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
G TAL A G+ +VV L+++GAN + P+ AA H ++V LL+N
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
Query: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 222
GA N + + G TPL A ++GH V HL+ G +G + AL +A + T++
Sbjct: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
Query: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
+L+ +PN ++ K G T L IA+ + + Q LL+ G VN ++G T L A R
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
G+V +VR LL + A I+ + +D T L+ A G+ + +L + TK+G +P+
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
Query: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 396
A + +++ V LLL A++ + TPLH+A ++A++LL +
Sbjct: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
Query: 397 PNSRALNGFTPLHIAC 412
PN G TP +I C
Sbjct: 400 PNKA---GETPYNIDC 412
Score = 166 bits (419), Expect = 3e-40
Identities = 127/415 (30%), Positives = 198/415 (47%), Gaps = 3/415 (0%)
Query: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
K LL+K + R G TPL IA ++ ++ +++ L+K GA+ + T L AS
Sbjct: 22 KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
Query: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
GH+ IV+ LL+ G + ++ T L A G T+V + LL + A + P+
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 508 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 567
AA GH ++V LLL+N A N + G TPL AAR+GH+E V LL A
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
Query: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
T L VA K G + + +L+R+ + N K+G T L +A + +IV+ LL G
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
Query: 628 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
+ P +G T L A + VE+ R+LLQ + T L+ A ++G+A MV +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
L + + K G TPL + ++ V ++L+ G V A + G TPLH+A +
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
Query: 748 KLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
KL + LL++ D + K G +P + + + + SP E D
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGD 436
Score = 161 bits (408), Expect = 5e-39
Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)
Query: 87 KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 146
+E ++ + LL K ++ + G T L IAA G E+V+EL+ GAN N + +T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
L A++E H+ +V+ LL+ G N G+T L A +G +VV L+++G V
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 207 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261
P + A R +LLQN + K G TPL AA +L + LL
Sbjct: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
Query: 262 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
GA V+ N +T L +A + G V+ +L R + KD T L A++ GH I
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
+ LLD G + ++G + + A +G H++ VR LLQ A+ID D+ T L+ A
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
G+ + + +L +G TPL A K ++ V+ELLL GA + AV + G TPL
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
Query: 442 HVA 444
H+A
Sbjct: 373 HIA 375
Score = 161 bits (408), Expect = 5e-39
Identities = 114/361 (31%), Positives = 174/361 (48%)
Query: 449 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508
++P +K LL++ + N +TPL +AA G+ E+ K L++N A N + D+ T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 568
A++ GH ++V+ LL+ N G T L A +G + V LL A+ +
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 569 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
P+ AA G + LLL+ A N + K G TPL A +L+ VK LL G
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
N T L +A K + + +L+ + N G T L +A++EGH E+V LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Query: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
N+ ++SG T L + GHV + L++ +D + T L+ A GN
Sbjct: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
Query: 749 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
+V+ +LQ D TK G +PL +A + + ++V LLL GA + V G TPL IA
Sbjct: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
Query: 809 R 809
R
Sbjct: 377 R 377
Score = 160 bits (404), Expect = 1e-38
Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)
Query: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212
+E ++ +K LLE + + E G TPL +A +QG+ +V LI
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
Query: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
+N N ++ +T L A+ ++++ + LL G ++ G
Sbjct: 59 --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
T L A +G +V LLL GA + P+ AA GH I +LL +GA +
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
Query: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
K G +P+ AA+ HL+CV+ LL A++D + +T L VA G+ + K +L
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
Query: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
+ N +G T L IA K+ H +++ LL G ++ SG T L A GH+ I
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
Query: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
V+ LLQ+ A ++ +T L+ A G+ + + +LQ KD +TPL A +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
Query: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 568
+ + +V+LLL+ A + G TPLHIA R G + LL + + K
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
Query: 569 GFTPLHVAAKYGKVRVAELLLERDAHP 595
G TP ++ + K + ++ R P
Sbjct: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
Score = 159 bits (401), Expect = 3e-38
Identities = 107/333 (32%), Positives = 168/333 (50%)
Query: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 546
K LL+ V+ + + QTPL AA G+ +VK L++N AN NL T L A++E
Sbjct: 22 KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
Query: 547 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 606
GHV V LL+ + G+T L A G+ V ELLL A+P+ G + P+
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 666
A + DIV LLL G + G TPL AA++ +E + LL G + E
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
Query: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726
+T L +A + G+ + V +L + N NL +K G T L + ++EGH + L+ G
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
Query: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
V+ R G T L A G++++V+ LLQ AD++ + + + L+ A ++G+ +V +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 787 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
L+ + DG TPL A ++ I V ++L
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
Score = 97.1 bits (240), Expect = 1e-19
Identities = 59/170 (34%), Positives = 92/170 (54%)
Query: 644 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703
++ + ++LL+ + + G TPL +AA++G+ E+V L+ AN NL + T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 704 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 763
L ++EGHV + + L+K GV ++ G+T L A + G +V+ LL H A+ +
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 764 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 813
P+ AA +GH DIV LLL+NGA N GTTPL A R G++
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
Score = 94.0 bits (232), Expect = 1e-18
Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)
Query: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
A++ T+ + A + G + L+ ++N +++G L +ASKEGH ++V +LL
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
+ + G+T L A G E+VR L+ A+++ + Q T LY A ++ + +V+
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
Query: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 218
+L+ + + T+DG TPL A + + VV L++ G K K LHIA R
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
Query: 219 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 257
+ A +LL+N + +L +K G TP +I ++ + Q+
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
Score = 65.5 bits (158), Expect = 5e-10
Identities = 44/159 (27%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 736
+E + + LL K + + N+ G TPL + A++G++ + LIK+G + +T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 737 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 796
L AS G++ +V+ LL+ ++ + G++ L A +G TD+V LLL +GA+P+
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 797 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 835
P+ A G+ D++ ++ + V SDK+
Sbjct: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKY 169
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 191 bits (486), Expect = 4e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 388
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 389 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 448
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
Query: 449 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
Query: 509 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 539
AA+ H V+ LL + A+ NL + GH P
Sbjct: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
Score = 186 bits (471), Expect = 2e-46
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 608
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
Query: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
Query: 789 N 789
+
Sbjct: 782 S 782
Score = 184 bits (466), Expect = 9e-46
Identities = 116/322 (36%), Positives = 166/322 (51%), Gaps = 2/322 (0%)
Query: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
LH+A AG E AK+LL N A N + TPLH A +V+LLL + N
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
T LH AA+ G + LLEK AS + +G TP+HVA ++G+ + +LL R
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVAR 652
+ GK+ PLH A +L IVKLL + G S ++ +G TPLH+AA++ VAR
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 712
L+ N S+ TPLH+AA+ GH LLL + A G T LHL A+ G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
Query: 713 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772
H+ +L++ V A + T LH+A+ +G+ ++V+ L+ ++ + G S LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
Query: 773 QAAQQGHTDIVTLLLKNGASPN 794
AAQ H V LL++GA N
Sbjct: 741 LAAQGRHAQTVETLLRHGAHIN 762
Score = 182 bits (461), Expect = 4e-45
Identities = 110/333 (33%), Positives = 168/333 (50%), Gaps = 2/333 (0%)
Query: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
V+ +G + LH+A G + LL A + TPLH A + E+L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384
L + AK ++ + +H AAQ RLLL+ +A ++++ + TP+HVA G
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHV 443
+ ++LL +G + + + + PLH A + H+ +++LL K G S++A T G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
A+ GH + + L+ + NV ++ +TPLH+AA GHT A+ LL A A D
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
T LH AAR GH VKLL+E A+ T LH+AA GH E V L+ +
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID- 729
Query: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
++G + LH+AA+ + E LL AH N
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 181 bits (458), Expect = 8e-45
Identities = 119/344 (34%), Positives = 179/344 (52%), Gaps = 3/344 (0%)
Query: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
Query: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
+A R +V LLL R + K +D+ T LH AA+NG + +LL+ A +
Sbjct: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFE 536
Query: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAK 396
G +P+H+A Q + VR+LL+ ++ D PLH AA GH + K+L + G
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
N++ L+G TPLH+A ++ H RV +L+ + ++ + TPLHVA+ GH + L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656
Query: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
L RGA T LH+AAR GH K L++ KA V A+ +QT LH AA GH+
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
Query: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
+V+ L+ + +L G + LH+AA+ H +TV LL A
Sbjct: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 167 bits (423), Expect = 9e-41
Identities = 97/263 (36%), Positives = 150/263 (57%), Gaps = 4/263 (1%)
Query: 569 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
Query: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 747
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
Query: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
Query: 808 KRLGYISVTDVLKVVTDETSFVL 830
R G+++ +K++ +E + VL
Sbjct: 678 ARNGHLA---TVKLLVEEKADVL 697
Score = 158 bits (399), Expect = 5e-38
Identities = 125/385 (32%), Positives = 184/385 (47%), Gaps = 16/385 (4%)
Query: 24 EKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLH 83
E+E S +KK DA S G+ K + L+ D++ +G + LH
Sbjct: 392 EREPSTSDLGTTDVQKKKLVDAIVS-------GDTSKLMKILQPQ-DVDLALDSGASLLH 443
Query: 84 LASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
LA + G + LL + ++G+T LH+A VV L+ +VNA+ +
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED 503
Query: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-- 201
+T L+ AAQ + LLE A+ N +G TP+ VA Q G EN+V L+ G
Sbjct: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
Query: 202 --KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQL 257
+GK LH AA LL P V ++T G TPLH+AA + VA++
Sbjct: 564 SLQGKDAWLPLHYAAWQGHL-PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI 622
Query: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
L++ + VN TPLH+A+ G+ RLLL RGA E T D T LH AARNGH
Sbjct: 623 LIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682
Query: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377
+ ++L++ A + A+ + +H+AA H + V L+ D ID L+ LH+
Sbjct: 683 LATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHL 741
Query: 378 AAHCGHHRVAKVLLDKGAKPNSRAL 402
AA H + + LL GA N ++L
Sbjct: 742 AAQGRHAQTVETLLRHGAHINLQSL 766
Score = 150 bits (378), Expect = 1e-35
Identities = 102/307 (33%), Positives = 149/307 (48%), Gaps = 2/307 (0%)
Query: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
G T+ + +L+ + +LA +G + LH+A G E LL A+ ++G TPL
Sbjct: 417 GDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
H+A + V ELLL R NA ++ T LH A + + +LLL + S + +
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
Query: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA- 692
G TP+H+A + Q + R LL+ G + + PLH AA +GH +V LL +
Sbjct: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
Query: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
+ N G TPLHL AQ GH VA +LI V+ + + TPLHVA+ G+ +
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655
Query: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
LL A A T GY+ LH AA+ GH V LL++ A T L +A G+
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715
Query: 813 ISVTDVL 819
V + L
Sbjct: 716 SEVVEEL 722
Score = 52.0 bits (123), Expect = 6e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
Query: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 187 bits (476), Expect = 6e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 115 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 173 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 227
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 279
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 280 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 337
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 338 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 396 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 450
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
Query: 451 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 507
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
Query: 508 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 566
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
Query: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
Score = 180 bits (457), Expect = 1e-44
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 276 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 333
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 390
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
Query: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 442
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
Query: 443 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 498
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
Query: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
Query: 559 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 606
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
Query: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 663
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
Query: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
Query: 724 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
Query: 783 VTLLLKN 789
V ++++
Sbjct: 596 VLTIIRS 602
Score = 174 bits (441), Expect = 7e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 309 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 367 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 477
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 533
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 594 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 641
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
Query: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 698
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
Query: 699 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
Query: 759 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 791
D N K + G + LH AA++GH V LLL + A
Sbjct: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
Score = 174 bits (440), Expect = 1e-42
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 297
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
Query: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
Query: 358 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
Query: 410 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 465
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
Query: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 523
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
Query: 524 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
Query: 581 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 634
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
Query: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
Query: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
L NK + LHL V +I+
Sbjct: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
Score = 149 bits (377), Expect = 2e-35
Identities = 133/473 (28%), Positives = 208/473 (43%), Gaps = 60/473 (12%)
Query: 408 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALL--------EKEASQACMTKKGFTPLHVA 576
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP--RGGSPHSPAWN 634
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 635 G--YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 693 ----NGNLG----------------------------------NKSGLTPLHLVAQEGHV 714
N G + G TPLH ++G
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
Query: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPL 771
+ L+ V + + ++ +PLH A+ YG I + LLQ +D +N G +PL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
Query: 772 HQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
H AA+ GH +V LLLK GA +G T L A GY T +KV+ D
Sbjct: 487 HLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGY---TQTMKVILD 535
Score = 141 bits (356), Expect = 5e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
Query: 129 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
Query: 181 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
Query: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 291
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
Query: 292 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 347
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
Query: 348 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
Query: 405 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
Query: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
V N + + LH+A EV ++++K
Sbjct: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
Score = 110 bits (275), Expect = 1e-23
Identities = 100/364 (27%), Positives = 157/364 (43%), Gaps = 52/364 (14%)
Query: 46 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMVVELLHKEI 102
AT A ++G+L+ L NG I+ + +H A+ +G VK+++ +
Sbjct: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSV 299
Query: 103 -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
I+ TT T LH A+L E+ L++ GA++N +G +PL +A +V
Sbjct: 300 DIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVN 359
Query: 162 FLLENGANQNV--------------------------------------ATEDGFTPLAV 183
LL GA ++ DG TPL
Sbjct: 360 LLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHY 419
Query: 184 ALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK-- 237
A +QG V +L+ + +K K + LH AA T LLQ+ + +L++
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
Query: 238 -TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296
G TPLH+AA + V QLLL +GA + + NG T LH AS G ++++LD
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNL 538
Query: 297 QIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 355
+ + +D T LH AAR GH + +LL H A I K S +H+A + V
Sbjct: 539 KCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVL 597
Query: 356 LLLQ 359
+++
Sbjct: 598 TIIR 601
Score = 59.7 bits (143), Expect = 3e-08
Identities = 50/192 (26%), Positives = 85/192 (44%), Gaps = 8/192 (4%)
Query: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---K 100
D T A R G + L V I++ +++ + LH A+ G + LL
Sbjct: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
Query: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
+L G T LH+AA G D+VV+ L+ GA + G+T L+ A+ + + +
Sbjct: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
Query: 161 KFLLENGAN-QNVATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARN 216
K +L+ + EDG T L A ++GH VA L+++ K + LH+A N
Sbjct: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHN 590
Query: 217 DDTRTAAVLLQN 228
++++
Sbjct: 591 KRKEVVLTIIRS 602
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 182 bits (461), Expect = 4e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 671
T L A + +VA LLQ G + + ++G+ P
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
Score = 178 bits (451), Expect = 5e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 506
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 567 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 741
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 801 TTPLAIAKRLGYISVTDVL 819
T L A G+ V DVL
Sbjct: 569 DTALTYACENGHTDVADVL 587
Score = 177 bits (450), Expect = 7e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
Query: 501 KDDQTPL 507
+D +T L
Sbjct: 598 EDMKTIL 604
Score = 173 bits (438), Expect = 2e-42
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 768 YSPLHQAAQQGHTDIVTLLLKNGA 791
+ L A + GHTD+ +LL+ GA
Sbjct: 569 DTALTYACENGHTDVADVLLQAGA 592
Score = 167 bits (424), Expect = 7e-41
Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVD 728
T L + GH VADVL++ G +D
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLD 595
Score = 162 bits (409), Expect = 4e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 440
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 559
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 678
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 739 HVASHYGNIKLVKFLLQHQADVN 761
A G+ + LLQ AD++
Sbjct: 573 TYACENGHTDVADVLLQAGADLD 595
Score = 150 bits (380), Expect = 9e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 140 bits (354), Expect = 9e-33
Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 14/336 (4%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + A+ G LD L + D+N+ + G L A G V +V L
Sbjct: 266 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L++ +E + G+T L AA AG EV R L+++GA +N S + + L +A + H
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
L++V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 442
Query: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
+AA AA+L++ N + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+ T L +A G + L+ GA IE TPL A++ GH+ + + LL GA
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
+ A T G + + A + H D +LLQ A++D
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 182 bits (461), Expect = 4e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
Query: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
Query: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 671
T L A + +VA LLQ G + + ++G+ P
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
Score = 178 bits (451), Expect = 5e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 506
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 567 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
Query: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 741
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
Query: 801 TTPLAIAKRLGYISVTDVL 819
T L A G+ V DVL
Sbjct: 558 DTALTYACENGHTDVADVL 576
Score = 177 bits (450), Expect = 7e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
Query: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
Query: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
Query: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
Query: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
Query: 501 KDDQTPL 507
+D +T L
Sbjct: 587 EDMKTIL 593
Score = 173 bits (438), Expect = 2e-42
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
Query: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
Query: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
Query: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
Query: 768 YSPLHQAAQQGHTDIVTLLLKNGA 791
+ L A + GHTD+ +LL+ GA
Sbjct: 558 DTALTYACENGHTDVADVLLQAGA 581
Score = 167 bits (424), Expect = 7e-41
Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 404
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 203 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 261
Query: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321
Query: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 523
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
Query: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 642
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
Query: 703 TPLHLVAQEGHVPVADVLIKHGVMVD 728
T L + GH VADVL++ G +D
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLD 584
Score = 162 bits (409), Expect = 4e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 440
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 559
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
Query: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
Query: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 678
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
Query: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
Query: 739 HVASHYGNIKLVKFLLQHQADVN 761
A G+ + LLQ AD++
Sbjct: 562 TYACENGHTDVADVLLQAGADLD 584
Score = 150 bits (380), Expect = 9e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
L+ G + + +H T L A ++
Sbjct: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
Query: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
Query: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
Query: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 140 bits (354), Expect = 9e-33
Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 14/336 (4%)
Query: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
DR K D T + A+ G LD L + D+N+ + G L A G V +V L
Sbjct: 255 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
L++ +E + G+T L AA AG EV R L+++GA +N S + + L +A + H
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
Query: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
L++V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 431
Query: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
+AA AA+L++ N + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 491
Query: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
+ T L +A G + L+ GA IE TPL A++ GH+ + + LL GA
Sbjct: 492 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 548
Query: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
+ A T G + + A + H D +LLQ A++D
Sbjct: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 169 bits (427), Expect = 3e-41
Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)
Query: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
TPLHVAA CG + +L+ KGA N+ +G TPLH+AC+K + V LLL AS +
Sbjct: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
Query: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 489
+G TPLH+A GH VK L+ ++ N K +TPLH+AAR G+ V + L
Sbjct: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
Query: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 532
LQN A + + +TPL CA ++++ L E + A
Sbjct: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644
Query: 533 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 568
+T+ + + ++R+ G +E V LLE ++ A T
Sbjct: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704
Query: 569 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
P H + K A+ L + N ++G +PLHVA H D++ LLL
Sbjct: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764
Query: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
G + + + PLH+A +Q +V + LL N + + G TPL A GH E
Sbjct: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824
Query: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
+VALLL A+ N N G T LH E HV V ++L+ HG V + T + A
Sbjct: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
Query: 743 HYGNIKLVKFL 753
N K+++ L
Sbjct: 885 Q--NSKIMELL 893
Score = 159 bits (403), Expect = 2e-38
Identities = 142/540 (26%), Positives = 229/540 (42%), Gaps = 53/540 (9%)
Query: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 405
A G+ + RLL Q D + D + PL C ++ P SR G
Sbjct: 406 ASGNQKEVERLLSQEDHDKDTVQ-KMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGH 464
Query: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
TPLH+A +++LL+ GA ++A G TPLH+A G+ + LL AS V
Sbjct: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
Query: 466 SNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
+ TPLH+A GH + K L+ +++ + TPLH AAR G+ +++ L
Sbjct: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584
Query: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTPL 573
L+N A+ + TPL A +L+++E +++S+A + +
Sbjct: 585 LQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640
Query: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
++ + + + + L AV +L++V+ LL A
Sbjct: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
Query: 634 NGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 680
+ + P A++ +V S G N S G +PLH+AA G
Sbjct: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHGR 756
Query: 681 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 740
A+++ LLL AN N PLHL Q+GH V L+ + G TPL
Sbjct: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816
Query: 741 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
A G+ +LV LLQH A +NA G + LH+A + H +V LLL +GAS ++
Sbjct: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
Query: 801 TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITI 860
T + A++ + ++L+VV P V + DV+E + ++T+
Sbjct: 877 RTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVTV 917
Score = 159 bits (403), Expect = 2e-38
Identities = 132/424 (31%), Positives = 191/424 (45%), Gaps = 58/424 (13%)
Query: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
+G+T LH+AA+ GQ ++ LV+ GA VNA G TPL++A Q+ + V LL A+
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
Query: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRT 221
V +G TPL +A GHE+ V L+ Y + RL LHIAAR
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE-SCRLDIGNEKGDTPLHIAARWGYQGV 580
Query: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ---LLLNRGASVNFTP-QNGITPLH 277
LLQN + ++ ++ TPL A + + L+V + L R + P Q+ +
Sbjct: 581 IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640
Query: 278 IASRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLD--------- 326
S+ + + Q ETK KD E+ L A +G + + LL+
Sbjct: 641 SISQESSTSSFSSMSASSRQEETK-KDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699
Query: 327 ---------------------------------HGAPIQAKTKNGLSPIHMAAQGDHLDC 353
G + +++G SP+H+AA D
Sbjct: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADL 759
Query: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
+ LLL++ A D PLH+A GH +V K LLD AKPN + L+G TPL AC
Sbjct: 760 IPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACS 819
Query: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
H ++ LLL+ GASI+A G T LH A H+ +V+ LL GAS V N + T
Sbjct: 820 GGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTA 879
Query: 474 LHMA 477
+ A
Sbjct: 880 VDCA 883
Score = 138 bits (347), Expect = 6e-32
Identities = 125/470 (26%), Positives = 193/470 (41%), Gaps = 83/470 (17%)
Query: 139 AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 198
++ +G TPL++AA ++ L+ GA N G TPL +A Q+G+++V L++
Sbjct: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517
Query: 199 YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLL 258
Y +V+ G TPLH+A Y + + + L
Sbjct: 518 YKASAEVQ-----------------------------DNNGNTPLHLACTYGHEDCVKAL 548
Query: 259 LN---RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
+ ++ + G TPLHIA+R G ++ LL GA E + + + TPL CA +
Sbjct: 549 VYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNS 608
Query: 316 G--------HVRISEILLDHGAPIQA---------------------------KTKNGLS 340
H+ AP+Q+ +TK
Sbjct: 609 KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYR 668
Query: 341 PIHM----AAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRV 386
+ A GD L+ VR LL++ D E + T+ P H C R+
Sbjct: 669 EVEKLLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRL 727
Query: 387 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 446
AKV G N + +G +PLH+A ++ LLLK GA+ A PLH+A
Sbjct: 728 AKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQ 786
Query: 447 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
GH +VK LL A PN ++ TPL A GH E+ LLQ+ A +NA T
Sbjct: 787 QGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTA 846
Query: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
LH A H +V+LLL + A+ + T + A + + +L ++
Sbjct: 847 LHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896
Score = 114 bits (285), Expect = 9e-25
Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)
Query: 46 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 103
AT A + G L L + NG LHLA GH V L++ ++
Sbjct: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556
Query: 104 -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 161
L+ +KG+T LHIAA G V+ L+ GA+ Q++ TPL A L V++
Sbjct: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616
Query: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 213
+ L Q + +P E+ + + + + L A
Sbjct: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676
Query: 214 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 264
+ D LL+ + D +S H AQ L + G
Sbjct: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
Query: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
VN T Q+G +PLH+A+ G ++ LLL GA + D+ PLH A + GH ++ + L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384
LD A K +G +P+ A G H + V LLLQ+ A I+ T LH A H
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
Query: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 436
V ++LL GA + + LN + C + + ++MELL AS+D V E+
Sbjct: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
Score = 97.1 bits (240), Expect = 1e-19
Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)
Query: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
H+A+ G + E LL ++ H + PL L +L P +P S
Sbjct: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461
Query: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
G+TPLH+AA Q + L+ G NA G TPLHLA Q+G+ + LLL +A+
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
Query: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 750
+ + +G TPLHL GH L+ + V +D G TPLH+A+ +G ++
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
Query: 751 KFLLQHQADVNAKTKLGYSPL 771
+ LLQ+ A + +L +PL
Sbjct: 582 ETLLQNGASTEIQNRLKETPL 602
Score = 79.3 bits (194), Expect = 3e-14
Identities = 70/276 (25%), Positives = 118/276 (42%), Gaps = 38/276 (13%)
Query: 20 QEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKAL-------DHLRNGVD-I 71
QE S+ +R + KK LRA G+L+ + L + D +
Sbjct: 644 QESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTV 703
Query: 72 NTCNQNGLNGLHLASKEGHV-KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
+ + + L K K + ++ + + T++ G++ LH+AAL G+ +++ L
Sbjct: 704 SAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLL 763
Query: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 190
+ +GAN A++ PL++A Q+ H +VVK LL++ A N G TPL A GH
Sbjct: 764 LKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHH 823
Query: 191 NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 250
+VA L+ +G I A N+ G T LH A +
Sbjct: 824 ELVALLLQHGAS---------INASNN--------------------KGNTALHEAVIEK 854
Query: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 286
++ V +LLL GASV + T + A + ++
Sbjct: 855 HVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIM 890
Score = 35.8 bits (81), Expect = 0.41
Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 3/98 (3%)
Query: 34 NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93
+ ++ KK T + A G+ + L++G IN N G LH A E HV +
Sbjct: 799 SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFV 858
Query: 94 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131
V LL ++ K+ TA+ A Q+ + EL+
Sbjct: 859 VELLLLHGASVQVLNKRQRTAVDCAE---QNSKIMELL 893
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,218,081
Number of Sequences: 37866
Number of extensions: 3412900
Number of successful extensions: 25635
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 379
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 10088
Number of HSP's gapped (non-prelim): 6194
length of query: 1897
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1780
effective length of database: 13,817,196
effective search space: 24594608880
effective search space used: 24594608880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.