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Search of human proteins with 215272341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens]
(296 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens] 608 e-174
gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens] 587 e-168
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 61 1e-09
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 61 1e-09
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 61 1e-09
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 56 4e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 53 3e-07
gi|16554627 WD repeat domain 5 [Homo sapiens] 53 3e-07
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 52 6e-07
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 52 6e-07
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ... 51 1e-06
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ... 51 1e-06
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s... 51 1e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 50 3e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 49 4e-06
gi|23199987 WD repeat domain 5B [Homo sapiens] 49 4e-06
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 49 5e-06
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens] 49 7e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 49 7e-06
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] 49 7e-06
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 48 9e-06
gi|157266266 WD repeat domain 86 [Homo sapiens] 48 9e-06
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ... 48 9e-06
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ... 48 9e-06
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ... 48 9e-06
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 48 9e-06
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 48 9e-06
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 48 9e-06
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 48 1e-05
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 48 1e-05
>gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens]
Length = 296
Score = 608 bits (1569), Expect = e-174
Identities = 296/296 (100%), Positives = 296/296 (100%)
Query: 1 MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE 60
MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE
Sbjct: 1 MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE 60
Query: 61 AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY 120
AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY
Sbjct: 61 AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY 120
Query: 121 RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS 180
RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS
Sbjct: 121 RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS 180
Query: 181 PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA 240
PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA
Sbjct: 181 PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA 240
Query: 241 LTLWHLRSSTPTTIFPIRAPQKHVTFYQDLVLTAAGNSCRVDVFTNLGYRAFSLSF 296
LTLWHLRSSTPTTIFPIRAPQKHVTFYQDLVLTAAGNSCRVDVFTNLGYRAFSLSF
Sbjct: 241 LTLWHLRSSTPTTIFPIRAPQKHVTFYQDLVLTAAGNSCRVDVFTNLGYRAFSLSF 296
>gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens]
Length = 341
Score = 587 bits (1513), Expect = e-168
Identities = 296/341 (86%), Positives = 296/341 (86%), Gaps = 45/341 (13%)
Query: 1 MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE 60
MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE
Sbjct: 1 MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSE 60
Query: 61 AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY 120
AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY
Sbjct: 61 AKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPY 120
Query: 121 RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS 180
RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS
Sbjct: 121 RTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERS 180
Query: 181 PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA 240
PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA
Sbjct: 181 PEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPA 240
Query: 241 LTLWHLRSSTPTTIFPIRAPQKHVTFYQDL------------------------------ 270
LTLWHLRSSTPTTIFPIRAPQKHVTFYQDL
Sbjct: 241 LTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGL 300
Query: 271 ---------------VLTAAGNSCRVDVFTNLGYRAFSLSF 296
VLTAAGNSCRVDVFTNLGYRAFSLSF
Sbjct: 301 LSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF 341
>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
Length = 919
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 95/234 (40%), Gaps = 24/234 (10%)
Query: 34 PCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQA---HDGPVYSMV-STDRHL 89
P G A G+N + + + + A E K+PVV F+ H G +Y + S L
Sbjct: 616 PAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 675
Query: 90 LSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENS----LILAG 145
L+ G + + ++L + P S+ I L + S LI AG
Sbjct: 676 LATGSNDK----YVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAG 731
Query: 146 -GDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSP-EVLSGGEDGAVRLWDLRTAKEV 203
GDC ++T D + G L GHT H LAL S + SG +D VR WDLR V
Sbjct: 732 AGDCNIYTTDCQRGQGLHALSGHTG--HILALYTWSGWMIASGSQDKTVRFWDLRVPSCV 789
Query: 204 QTIEVYKHEECSR------PHNGRWIGCLATDSDWMV--CGGGPALTLWHLRSS 249
+ + H S +GR + DS M+ GG + +H SS
Sbjct: 790 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 843
>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
Length = 927
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 95/234 (40%), Gaps = 24/234 (10%)
Query: 34 PCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQA---HDGPVYSMV-STDRHL 89
P G A G+N + + + + A E K+PVV F+ H G +Y + S L
Sbjct: 624 PAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 683
Query: 90 LSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENS----LILAG 145
L+ G + + ++L + P S+ I L + S LI AG
Sbjct: 684 LATGSNDK----YVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAG 739
Query: 146 -GDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSP-EVLSGGEDGAVRLWDLRTAKEV 203
GDC ++T D + G L GHT H LAL S + SG +D VR WDLR V
Sbjct: 740 AGDCNIYTTDCQRGQGLHALSGHTG--HILALYTWSGWMIASGSQDKTVRFWDLRVPSCV 797
Query: 204 QTIEVYKHEECSR------PHNGRWIGCLATDSDWMV--CGGGPALTLWHLRSS 249
+ + H S +GR + DS M+ GG + +H SS
Sbjct: 798 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 851
>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
Length = 920
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 95/234 (40%), Gaps = 24/234 (10%)
Query: 34 PCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQA---HDGPVYSMV-STDRHL 89
P G A G+N + + + + A E K+PVV F+ H G +Y + S L
Sbjct: 617 PAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 676
Query: 90 LSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENS----LILAG 145
L+ G + + ++L + P S+ I L + S LI AG
Sbjct: 677 LATGSNDK----YVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAG 732
Query: 146 -GDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSP-EVLSGGEDGAVRLWDLRTAKEV 203
GDC ++T D + G L GHT H LAL S + SG +D VR WDLR V
Sbjct: 733 AGDCNIYTTDCQRGQGLHALSGHTG--HILALYTWSGWMIASGSQDKTVRFWDLRVPSCV 790
Query: 204 QTIEVYKHEECSR------PHNGRWIGCLATDSDWMV--CGGGPALTLWHLRSS 249
+ + H S +GR + DS M+ GG + +H SS
Sbjct: 791 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 844
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 55.8 bits (133), Expect = 4e-08
Identities = 50/198 (25%), Positives = 80/198 (40%), Gaps = 20/198 (10%)
Query: 11 LGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVV 70
L + E LQ L + SP G LA G G I IFSL LS E V
Sbjct: 52 LRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL---LSGEGN-------V 101
Query: 71 TFQAHDGPVYSMVSTDRH-LLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEI 129
TF H + ++ L++G + +W + + G YR I
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL---------YRLKGHKDAI 152
Query: 130 NALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGED 189
L + ++N L+ +G D + DL+T + + GH + L L +++G D
Sbjct: 153 TQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASD 212
Query: 190 GAVRLWDLRTAKEVQTIE 207
+R+WD+ +E++ E
Sbjct: 213 SELRVWDIAYLQEIEDPE 230
Score = 43.5 bits (101), Expect = 2e-04
Identities = 33/134 (24%), Positives = 54/134 (40%), Gaps = 10/134 (7%)
Query: 64 ESKKPVVTFQAHDGPVYSM-VSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRT 122
++ K ++ H PV M +S D L++ G + +W K L+
Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDD---- 634
Query: 123 SLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPE 182
+ L VPK + AG D ++ D + + L GH I CLA+
Sbjct: 635 -----SVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDY 689
Query: 183 VLSGGEDGAVRLWD 196
V+S D ++RLW+
Sbjct: 690 VVSSSHDKSLRLWE 703
Score = 40.8 bits (94), Expect = 0.001
Identities = 38/167 (22%), Positives = 70/167 (41%), Gaps = 13/167 (7%)
Query: 34 PCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSM-VSTDRHLLSA 92
P + + G G++ ++ L+S E T AHDG ++SM +S D+
Sbjct: 464 PGDRQVVIGTKTGKLQLYDLASGNLLE----------TIDAHDGALWSMSLSPDQRGFVT 513
Query: 93 GDGEVKAWLWAEMLKKGCKELWRRQPPYRT-SLEVPE-INALLLVPKENSLILAGGDCQL 150
G + W L K +R +T +L++ E + + P + L ++ DC +
Sbjct: 514 GGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTV 573
Query: 151 HTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDL 197
++T F L GH + C+ + + +G D V++W L
Sbjct: 574 KIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGL 620
Score = 33.5 bits (75), Expect = 0.23
Identities = 15/68 (22%), Positives = 30/68 (44%)
Query: 135 VPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRL 194
VP + +++ +L DL +G + H + ++L ++GG D +V+
Sbjct: 463 VPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKF 522
Query: 195 WDLRTAKE 202
WD K+
Sbjct: 523 WDFELVKD 530
Score = 33.1 bits (74), Expect = 0.30
Identities = 28/138 (20%), Positives = 56/138 (40%), Gaps = 11/138 (7%)
Query: 135 VPKENSLILAGG-DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVR 193
+ + +LI G D + L+ G + L H D + L +S + G+D ++
Sbjct: 599 ISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIK 658
Query: 194 LWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSSTPT 252
WD + +QT+E + H W ++ D++V +L LW R+ P
Sbjct: 659 QWDADKFEHIQTLEGH--------HQEIWCLAVSPSGDYVVSSSHDKSLRLWE-RTREPL 709
Query: 253 TIFPIRAPQKHVTFYQDL 270
+ R ++ + + +
Sbjct: 710 ILEEEREMEREAEYEESV 727
Score = 28.9 bits (63), Expect = 5.7
Identities = 20/50 (40%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 164 LRGHTDYI-HCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHE 212
L+GH D I L LRE++ V SG +D V+ WDL T +T+ ++ E
Sbjct: 145 LKGHKDAITQALFLREKNLLVTSG-KDTMVKWWDLDTQHCFKTMVGHRTE 193
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 53.1 bits (126), Expect = 3e-07
Identities = 23/71 (32%), Positives = 42/71 (59%)
Query: 139 NSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLR 198
N L+ A D L D+ +G + L+GH++Y+ C +S ++SG D +VR+WD++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 199 TAKEVQTIEVY 209
T K ++T+ +
Sbjct: 160 TGKCLKTLPAH 170
Score = 37.0 bits (84), Expect = 0.021
Identities = 16/71 (22%), Positives = 34/71 (47%)
Query: 136 PKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLW 195
P+ N ++ D + D++TG + L H+D + + ++S DG R+W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 196 DLRTAKEVQTI 206
D + + ++T+
Sbjct: 199 DTASGQCLKTL 209
Score = 34.7 bits (78), Expect = 0.10
Identities = 43/196 (21%), Positives = 78/196 (39%), Gaps = 21/196 (10%)
Query: 25 MTIFSQSVSPCGKFLAAGNNYGQIAIFS-LSSALSSEAKEESK--------KPVVTFQAH 75
+ I+ S C K L +NY F+ S+ + S + +ES K + T AH
Sbjct: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170
Query: 76 DGPVYSM-VSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLL 134
PV ++ + D L+ + + +W + K L + P ++ +
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDDNPPVSFVKF 222
Query: 135 VPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALR---ERSPEVLSGGEDGA 191
P ++ A D L D G + GH + +C+ ++SG ED
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 192 VRLWDLRTAKEVQTIE 207
V +W+L+T + VQ ++
Sbjct: 283 VYIWNLQTKEIVQKLQ 298
Score = 29.6 bits (65), Expect = 3.3
Identities = 16/79 (20%), Positives = 37/79 (46%)
Query: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGE 188
++++ P L + D + G F + + GH I +A S ++S +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 189 DGAVRLWDLRTAKEVQTIE 207
D +++WD+ + K ++T++
Sbjct: 108 DKTLKIWDVSSGKCLKTLK 126
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 53.1 bits (126), Expect = 3e-07
Identities = 23/71 (32%), Positives = 42/71 (59%)
Query: 139 NSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLR 198
N L+ A D L D+ +G + L+GH++Y+ C +S ++SG D +VR+WD++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 199 TAKEVQTIEVY 209
T K ++T+ +
Sbjct: 160 TGKCLKTLPAH 170
Score = 37.0 bits (84), Expect = 0.021
Identities = 16/71 (22%), Positives = 34/71 (47%)
Query: 136 PKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLW 195
P+ N ++ D + D++TG + L H+D + + ++S DG R+W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 196 DLRTAKEVQTI 206
D + + ++T+
Sbjct: 199 DTASGQCLKTL 209
Score = 34.7 bits (78), Expect = 0.10
Identities = 43/196 (21%), Positives = 78/196 (39%), Gaps = 21/196 (10%)
Query: 25 MTIFSQSVSPCGKFLAAGNNYGQIAIFS-LSSALSSEAKEESK--------KPVVTFQAH 75
+ I+ S C K L +NY F+ S+ + S + +ES K + T AH
Sbjct: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170
Query: 76 DGPVYSM-VSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLL 134
PV ++ + D L+ + + +W + K L + P ++ +
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDDNPPVSFVKF 222
Query: 135 VPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALR---ERSPEVLSGGEDGA 191
P ++ A D L D G + GH + +C+ ++SG ED
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 192 VRLWDLRTAKEVQTIE 207
V +W+L+T + VQ ++
Sbjct: 283 VYIWNLQTKEIVQKLQ 298
Score = 29.6 bits (65), Expect = 3.3
Identities = 16/79 (20%), Positives = 37/79 (46%)
Query: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGE 188
++++ P L + D + G F + + GH I +A S ++S +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 189 DGAVRLWDLRTAKEVQTIE 207
D +++WD+ + K ++T++
Sbjct: 108 DKTLKIWDVSSGKCLKTLK 126
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 52.0 bits (123), Expect = 6e-07
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 5/85 (5%)
Query: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGE 188
+ AL L +EN L+ D + DL++G TR+ GH I C+ L + ++SGG
Sbjct: 456 VRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--RLVSGGR 513
Query: 189 DGAVRLWDLRTAKEVQTIEVYKHEE 213
D V++WD+ T K ++T ++H++
Sbjct: 514 DCQVKVWDVDTGKCLKT---FRHKD 535
Score = 33.9 bits (76), Expect = 0.18
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 141 LILAGGDCQLHTMDL-ETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRT 199
LI + ++H +D+ + RGH + L L E +LSG D ++R WDL++
Sbjct: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 52.0 bits (123), Expect = 6e-07
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 5/85 (5%)
Query: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGE 188
+ AL L +EN L+ D + DL++G TR+ GH I C+ L + ++SGG
Sbjct: 456 VRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--RLVSGGR 513
Query: 189 DGAVRLWDLRTAKEVQTIEVYKHEE 213
D V++WD+ T K ++T ++H++
Sbjct: 514 DCQVKVWDVDTGKCLKT---FRHKD 535
Score = 33.9 bits (76), Expect = 0.18
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 141 LILAGGDCQLHTMDL-ETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRT 199
LI + ++H +D+ + RGH + L L E +LSG D ++R WDL++
Sbjct: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
sapiens]
Length = 621
Score = 51.2 bits (121), Expect = 1e-06
Identities = 38/154 (24%), Positives = 63/154 (40%), Gaps = 20/154 (12%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL+ T R +GHTD C+ + + + +G
Sbjct: 426 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 485
Query: 187 GEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHL 246
G D VR WDLR +++Q + + + S H + DW+ G
Sbjct: 486 GLDNTVRCWDLREGRQLQQHD-FSSQIFSLGH--------CPNQDWLAVG---------- 526
Query: 247 RSSTPTTIFPIRAPQKH-VTFYQDLVLTAAGNSC 279
S+ I +R P+K+ + ++ VL+ SC
Sbjct: 527 MESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 560
>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
sapiens]
Length = 706
Score = 51.2 bits (121), Expect = 1e-06
Identities = 38/154 (24%), Positives = 63/154 (40%), Gaps = 20/154 (12%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL+ T R +GHTD C+ + + + +G
Sbjct: 562 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 621
Query: 187 GEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHL 246
G D VR WDLR +++Q + + + S H + DW+ G
Sbjct: 622 GLDNTVRCWDLREGRQLQQHD-FSSQIFSLGH--------CPNQDWLAVG---------- 662
Query: 247 RSSTPTTIFPIRAPQKH-VTFYQDLVLTAAGNSC 279
S+ I +R P+K+ + ++ VL+ SC
Sbjct: 663 MESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
sapiens]
Length = 743
Score = 51.2 bits (121), Expect = 1e-06
Identities = 38/154 (24%), Positives = 63/154 (40%), Gaps = 20/154 (12%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL+ T R +GHTD C+ + + + +G
Sbjct: 548 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 607
Query: 187 GEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHL 246
G D VR WDLR +++Q + + + S H + DW+ G
Sbjct: 608 GLDNTVRCWDLREGRQLQQHD-FSSQIFSLGH--------CPNQDWLAVG---------- 648
Query: 247 RSSTPTTIFPIRAPQKH-VTFYQDLVLTAAGNSC 279
S+ I +R P+K+ + ++ VL+ SC
Sbjct: 649 MESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 682
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 49.7 bits (117), Expect = 3e-06
Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
Query: 107 KKGCKELWRRQPP--YRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVL 164
K+ KE W +PP Y S + ++ P + ++ A D + D ETG F R L
Sbjct: 88 KRDPKE-WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL 146
Query: 165 RGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECS 215
+GHTD + ++ + S D ++LWD + + ++T+ + H S
Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197
Score = 37.4 bits (85), Expect = 0.016
Identities = 18/76 (23%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 137 KENSLILAGG-DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLW 195
K +L+G D + D+ TG L GH +++ + +LS +D +R+W
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Query: 196 DLRTAKEVQTIEVYKH 211
D + + ++T+ ++H
Sbjct: 366 DYKNKRCMKTLNAHEH 381
Score = 34.7 bits (78), Expect = 0.10
Identities = 18/84 (21%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGE 188
++++ ++P + ++ A D + +++TG + GH +++ + + + S
Sbjct: 195 VSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSN 254
Query: 189 DGAVRLWDLRTAKEVQTIEVYKHE 212
D VR+W + T KE + E+ +HE
Sbjct: 255 DQTVRVWVVAT-KECKA-ELREHE 276
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 49.3 bits (116), Expect = 4e-06
Identities = 44/196 (22%), Positives = 80/196 (40%), Gaps = 37/196 (18%)
Query: 129 INALLLVPKENSLILAGGD-CQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGG 187
+++L+L L+ GGD C+++ + L GHT + + L +++G
Sbjct: 23 VSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS 82
Query: 188 EDGAVRLWDLRTAKEVQTIEVYKHEECSRPHN--GRWI-----------------GCL-- 226
+ G++R+WDL AK ++T+ +K CS + G ++ GC+
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 227 -------------ATDSDWMVCGGGP-ALTLWHLRSSTPTTIFP-IRAPQKHVTFYQDLV 271
+ D W+ + LW L + + FP P V F+ +
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Query: 272 LTAAGNSCRVDVFTNL 287
L A+G+S R F +L
Sbjct: 203 LLASGSSDRTIRFWDL 218
Score = 42.0 bits (97), Expect = 6e-04
Identities = 40/175 (22%), Positives = 65/175 (37%), Gaps = 26/175 (14%)
Query: 37 KFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRH----LLSA 92
+ + AG+ G I ++ L +A K + T H + S+ D H +++
Sbjct: 76 ELIVAGSQSGSIRVWDLEAA----------KILRTLMGHKANICSL---DFHPYGEFVAS 122
Query: 93 GDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHT 152
G + LW ++ +KGC +R + L P L A D +
Sbjct: 123 GSQDTNIKLW-DIRRKGCVFRYRGHSQ--------AVRCLRFSPDGKWLASAADDHTVKL 173
Query: 153 MDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIE 207
DL G GHT ++ + + SG D +R WDL + V IE
Sbjct: 174 WDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 4e-06
Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 6/94 (6%)
Query: 128 EINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGG 187
EI+ + + L+ A D L D+ +G + L+GH++Y+ C S ++SG
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 188 EDGAVRLWDLRTAKEVQTIEVYK------HEECS 215
D V++W+++T K ++T+ + H CS
Sbjct: 145 FDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCS 178
Score = 35.8 bits (81), Expect = 0.046
Identities = 17/71 (23%), Positives = 34/71 (47%)
Query: 136 PKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLW 195
P N +I D + +++TG + L H+D + + ++SG DG R+W
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 196 DLRTAKEVQTI 206
D + + ++T+
Sbjct: 195 DAASGQCLKTL 205
Score = 33.9 bits (76), Expect = 0.18
Identities = 15/50 (30%), Positives = 29/50 (58%)
Query: 158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIE 207
G + + L GH I +A S ++S +D ++LWD+R+ K ++T++
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK 122
Score = 33.5 bits (75), Expect = 0.23
Identities = 20/84 (23%), Positives = 37/84 (44%), Gaps = 3/84 (3%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALR---ERSPEV 183
P ++ + P ++ A D L D G + GH + +C+ +
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 184 LSGGEDGAVRLWDLRTAKEVQTIE 207
+SG ED V +W+L+T + VQ ++
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQ 294
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/68 (39%), Positives = 35/68 (51%)
Query: 131 ALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDG 190
+L P L AG D +L DL +GT + LRGHTD I L S + S D
Sbjct: 473 SLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532
Query: 191 AVRLWDLR 198
+VR+WD+R
Sbjct: 533 SVRVWDIR 540
Score = 39.3 bits (90), Expect = 0.004
Identities = 31/130 (23%), Positives = 52/130 (40%), Gaps = 12/130 (9%)
Query: 70 VTFQAHDGPVYSM-VSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSL-EVP 127
V +Q H PV+ + +S ++G + A LW+ + R P R +
Sbjct: 378 VLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWS----------FDRTYPLRIYAGHLA 427
Query: 128 EINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGG 187
+++ + P N L D + + G R+ GH + LA + S G
Sbjct: 428 DVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG 487
Query: 188 EDGAVRLWDL 197
ED ++LWDL
Sbjct: 488 EDQRLKLWDL 497
Score = 33.5 bits (75), Expect = 0.23
Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 19/115 (16%)
Query: 83 VSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLI 142
+S D LL+AG LW+ KK + P++ + + +L +++
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRSKK------LKSEPHQVDVSRIHLACDILEEEDDE-- 327
Query: 143 LAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDL 197
D GT ++LRGH ++ S +LS ED ++R WDL
Sbjct: 328 -----------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
Score = 32.0 bits (71), Expect = 0.67
Identities = 22/91 (24%), Positives = 34/91 (37%), Gaps = 11/91 (12%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPH--N 219
R+ GH + C+ S + +G D VRLW + V+ ++ S N
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479
Query: 220 GRWIGCLATDSDWMVCGGGPALTLWHLRSST 250
G+++ D L LW L S T
Sbjct: 480 GKYLASAGEDQ---------RLKLWDLASGT 501
>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
Length = 770
Score = 48.5 bits (114), Expect = 7e-06
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL T R +GHTD C+ + ++ +G
Sbjct: 575 PACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTG 634
Query: 187 GEDGAVRLWDLRTAKEVQ----TIEVYKHEECSRPHNGRWI 223
G D VR WDLR +++Q T +++ C G W+
Sbjct: 635 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP---TGEWL 672
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 48.5 bits (114), Expect = 7e-06
Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 1/68 (1%)
Query: 141 LILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPE-VLSGGEDGAVRLWDLRT 199
L A D + D ETG + L+GHT +++ R P+ V +G +DG V+LWD+R
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
Query: 200 AKEVQTIE 207
+QT +
Sbjct: 184 KAAIQTFQ 191
Score = 45.4 bits (106), Expect = 6e-05
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 109 GCKELW--RRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRG 166
G +LW R++ +T ++ A+ + +I G D + DL T +RG
Sbjct: 174 GTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233
Query: 167 HTDYIHCLALRERSPEVLSGGEDGAVRLWDLR 198
H D + L+L +LS D VR+WD+R
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 30.4 bits (67), Expect = 1.9
Identities = 12/40 (30%), Positives = 23/40 (57%)
Query: 167 HTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
+T + + + S +++SGG D +++WDLR K T+
Sbjct: 192 NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231
Score = 28.9 bits (63), Expect = 5.7
Identities = 47/220 (21%), Positives = 70/220 (31%), Gaps = 49/220 (22%)
Query: 73 QAHDGPVYSMVSTDRH----LLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVP- 127
Q GP +V R LL AG G A + L + PP +SL+ P
Sbjct: 5 QKRKGPELPLVPVKRQRHELLLGAGSGP-----GAGQQQATPGALLQAGPPRCSSLQAPI 59
Query: 128 --------EINALLLVPKENSLILAG-----------GDCQLHTMDLETGTFTRVLRGHT 168
E+ P ++L AG GDC + L+GH+
Sbjct: 60 MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA----------TLKGHS 109
Query: 169 DYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKH--EECSRPHNGRWIGCL 226
+ L + S D V +WD T + V+ ++ + C G + C
Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
Query: 227 ATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTF 266
+D + LW +R F VTF
Sbjct: 170 GSDDG--------TVKLWDIRKKAAIQTFQNTYQVLAVTF 201
>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
Length = 773
Score = 48.5 bits (114), Expect = 7e-06
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL T R +GHTD C+ + ++ +G
Sbjct: 578 PACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTG 637
Query: 187 GEDGAVRLWDLRTAKEVQ----TIEVYKHEECSRPHNGRWI 223
G D VR WDLR +++Q T +++ C G W+
Sbjct: 638 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP---TGEWL 675
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 48.1 bits (113), Expect = 9e-06
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 13/110 (11%)
Query: 141 LILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTA 200
++ A GD + T F R L GH I CL R+R V+SG D +RLWD+
Sbjct: 376 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL--VVSGSSDNTIRLWDIECG 433
Query: 201 KEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSS 249
++ +E HEE R C+ D+ +V G + +W L+++
Sbjct: 434 ACLRVLE--GHEELVR--------CIRFDNKRIVSGAYDGKIKVWDLQAA 473
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/182 (20%), Positives = 75/182 (41%), Gaps = 16/182 (8%)
Query: 86 DRHLLSA-GDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILA 144
D++++SA GD +K W + C+ + +L + L ++ ++
Sbjct: 373 DKYIVSASGDRTIKVWSTST-----CE--------FVRTLNGHKRGIACLQYRDRLVVSG 419
Query: 145 GGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQ 204
D + D+E G RVL GH + + C +R + ++SG DG +++WDL+ A + +
Sbjct: 420 SSDNTIRLWDIECGACLRVLEGHEELVRC--IRFDNKRIVSGAYDGKIKVWDLQAALDPR 477
Query: 205 TIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHV 264
H+GR + + + +W + P+ R+P +
Sbjct: 478 APASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTY 537
Query: 265 TF 266
T+
Sbjct: 538 TY 539
Score = 44.3 bits (103), Expect = 1e-04
Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 15/120 (12%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGR 221
+VL GHT + CL ER +++G D VR+WD+ T + + T+ HN
Sbjct: 274 KVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTL---------IHHNEA 322
Query: 222 WIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPI----RAPQKHVTFYQDLVLTAAGN 277
+ ++ + C ++ +W + S+T T+ + RA V F +++A+G+
Sbjct: 323 VLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGD 382
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 48.1 bits (113), Expect = 9e-06
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 16/128 (12%)
Query: 72 FQAHDGPVYSMVSTDRHLLS-AGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEIN 130
F+ H G V + +R + S + D VK WL E R +R ++ + +
Sbjct: 231 FREHRGSVICLELVNRLVYSGSADRTVKCWL------ADTGECVRTFTAHRRNVSALKYH 284
Query: 131 ALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDG 190
A +L GD D ++G RV RGHT I+C+ + + + DG
Sbjct: 285 A-------GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQV--HGQVLYTASHDG 335
Query: 191 AVRLWDLR 198
A+RLWD+R
Sbjct: 336 ALRLWDVR 343
Score = 38.1 bits (87), Expect = 0.009
Identities = 31/142 (21%), Positives = 59/142 (41%), Gaps = 14/142 (9%)
Query: 141 LILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTA 200
L+ D + +G + LRGHT + CL L +G D +R WD+ +
Sbjct: 166 LVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSG 225
Query: 201 KEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAP 260
++++ R H G I CL + +V G T+ + T + A
Sbjct: 226 EQLRVF---------REHRGSVI-CLEL-VNRLVYSGSADRTVKCWLADTGECVRTFTAH 274
Query: 261 QKHVT---FYQDLVLTAAGNSC 279
+++V+ ++ + T +G++C
Sbjct: 275 RRNVSALKYHAGTLFTGSGDAC 296
Score = 33.1 bits (74), Expect = 0.30
Identities = 28/128 (21%), Positives = 49/128 (38%), Gaps = 17/128 (13%)
Query: 87 RHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGG 146
R L + DG + W A+ C L + Y T ++ ++ +
Sbjct: 29 RLLTGSEDGTARLWSTAD---GQCCALLQGHESYVTFCQL----------EDEAAFTCSA 75
Query: 147 DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
DC + D+ TG +V RGHT ++ + + ++ S D R+W + K +
Sbjct: 76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSV--DKGQMSR 131
Query: 207 EVYKHEEC 214
E H C
Sbjct: 132 EFRGHRNC 139
Score = 31.2 bits (69), Expect = 1.1
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLW 195
G+ RV H I+ L+L +L+G EDG RLW
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLW 42
>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
sapiens]
Length = 769
Score = 48.1 bits (113), Expect = 9e-06
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL T R +GHTD C+ + ++ +G
Sbjct: 574 PACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTG 633
Query: 187 GEDGAVRLWDLRTAKEVQ----TIEVYKHEECSRPHNGRWI 223
G D VR WDLR +++Q T +++ C G W+
Sbjct: 634 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP---TGEWL 671
Score = 29.6 bits (65), Expect = 3.3
Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 12/110 (10%)
Query: 143 LAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKE 202
LAG H + T H + + + + + V +GG+ G V++WD+
Sbjct: 465 LAGPGIPRHARQINT-------LSHGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGS 516
Query: 203 VQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSSTP 251
I +C N L D ++ GG LT+W L S TP
Sbjct: 517 KSPISQL---DCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTP 563
>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
sapiens]
Length = 760
Score = 48.1 bits (113), Expect = 9e-06
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL T R +GHTD C+ + ++ +G
Sbjct: 565 PACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTG 624
Query: 187 GEDGAVRLWDLRTAKEVQ----TIEVYKHEECSRPHNGRWI 223
G D VR WDLR +++Q T +++ C G W+
Sbjct: 625 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP---TGEWL 662
Score = 29.6 bits (65), Expect = 3.3
Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 12/110 (10%)
Query: 143 LAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKE 202
LAG H + T H + + + + + V +GG+ G V++WD+
Sbjct: 456 LAGPGIPRHARQINT-------LSHGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGS 507
Query: 203 VQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSSTP 251
I +C N L D ++ GG LT+W L S TP
Sbjct: 508 KSPISQL---DCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTP 554
>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
sapiens]
Length = 772
Score = 48.1 bits (113), Expect = 9e-06
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 127 PEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSG 186
P AL + P D + DL T R +GHTD C+ + ++ +G
Sbjct: 577 PACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTG 636
Query: 187 GEDGAVRLWDLRTAKEVQ----TIEVYKHEECSRPHNGRWI 223
G D VR WDLR +++Q T +++ C G W+
Sbjct: 637 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP---TGEWL 674
Score = 29.6 bits (65), Expect = 3.3
Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 12/110 (10%)
Query: 143 LAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKE 202
LAG H + T H + + + + + V +GG+ G V++WD+
Sbjct: 468 LAGPGIPRHARQINT-------LSHGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGS 519
Query: 203 VQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSSTP 251
I +C N L D ++ GG LT+W L S TP
Sbjct: 520 KSPISQL---DCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTP 566
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 48.1 bits (113), Expect = 9e-06
Identities = 38/145 (26%), Positives = 66/145 (45%), Gaps = 27/145 (18%)
Query: 111 KELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDY 170
++LW R P +VP+++ L+L N D Q+ +++TG L GH D
Sbjct: 108 RKLWARHHP-----QVPDVSCLVLATGLN-------DGQIKIWEVQTGLLLLNLSGHQDV 155
Query: 171 IHCLALRERSPEVL-SGGEDGAVRLWDL-RTAKEVQTIEVYKHEECSRPHNGRWIGCLAT 228
+ L+ +L S D +R+WDL + K++Q + + +W+ C +
Sbjct: 156 VRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHL----------QWVYCCSI 205
Query: 229 DSDW-MVC--GGGPALTLWHLRSST 250
D M+C G ++ LW +RS T
Sbjct: 206 SPDCSMLCSAAGEKSVFLWSMRSYT 230
Score = 32.0 bits (71), Expect = 0.67
Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 141 LILAGGDCQLHTMDLET-GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRT 199
L+ A D L DL G +VL GH +++C ++ + S + +V LW +R+
Sbjct: 169 LVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRS 228
Query: 200 AKEVQTIE 207
++ +E
Sbjct: 229 YTLIRKLE 236
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 48.1 bits (113), Expect = 9e-06
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 13/110 (11%)
Query: 141 LILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTA 200
++ A GD + T F R L GH I CL R+R V+SG D +RLWD+
Sbjct: 342 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL--VVSGSSDNTIRLWDIECG 399
Query: 201 KEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSS 249
++ +E HEE R C+ D+ +V G + +W L+++
Sbjct: 400 ACLRVLE--GHEELVR--------CIRFDNKRIVSGAYDGKIKVWDLQAA 439
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/182 (20%), Positives = 75/182 (41%), Gaps = 16/182 (8%)
Query: 86 DRHLLSA-GDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILA 144
D++++SA GD +K W + C+ + +L + L ++ ++
Sbjct: 339 DKYIVSASGDRTIKVWSTST-----CE--------FVRTLNGHKRGIACLQYRDRLVVSG 385
Query: 145 GGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQ 204
D + D+E G RVL GH + + C +R + ++SG DG +++WDL+ A + +
Sbjct: 386 SSDNTIRLWDIECGACLRVLEGHEELVRC--IRFDNKRIVSGAYDGKIKVWDLQAALDPR 443
Query: 205 TIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHV 264
H+GR + + + +W + P+ R+P +
Sbjct: 444 APASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTY 503
Query: 265 TF 266
T+
Sbjct: 504 TY 505
Score = 44.3 bits (103), Expect = 1e-04
Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 15/120 (12%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGR 221
+VL GHT + CL ER +++G D VR+WD+ T + + T+ HN
Sbjct: 240 KVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTL---------IHHNEA 288
Query: 222 WIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPI----RAPQKHVTFYQDLVLTAAGN 277
+ ++ + C ++ +W + S+T T+ + RA V F +++A+G+
Sbjct: 289 VLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGD 348
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 48.1 bits (113), Expect = 9e-06
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 13/110 (11%)
Query: 141 LILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTA 200
++ A GD + T F R L GH I CL R+R V+SG D +RLWD+
Sbjct: 363 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL--VVSGSSDNTIRLWDIECG 420
Query: 201 KEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGG-GPALTLWHLRSS 249
++ +E HEE R C+ D+ +V G + +W L+++
Sbjct: 421 ACLRVLE--GHEELVR--------CIRFDNKRIVSGAYDGKIKVWDLQAA 460
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/182 (20%), Positives = 75/182 (41%), Gaps = 16/182 (8%)
Query: 86 DRHLLSA-GDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILA 144
D++++SA GD +K W + C+ + +L + L ++ ++
Sbjct: 360 DKYIVSASGDRTIKVWSTST-----CE--------FVRTLNGHKRGIACLQYRDRLVVSG 406
Query: 145 GGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQ 204
D + D+E G RVL GH + + C +R + ++SG DG +++WDL+ A + +
Sbjct: 407 SSDNTIRLWDIECGACLRVLEGHEELVRC--IRFDNKRIVSGAYDGKIKVWDLQAALDPR 464
Query: 205 TIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHV 264
H+GR + + + +W + P+ R+P +
Sbjct: 465 APASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTY 524
Query: 265 TF 266
T+
Sbjct: 525 TY 526
Score = 44.3 bits (103), Expect = 1e-04
Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 15/120 (12%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGR 221
+VL GHT + CL ER +++G D VR+WD+ T + + T+ HN
Sbjct: 261 KVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTL---------IHHNEA 309
Query: 222 WIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPI----RAPQKHVTFYQDLVLTAAGN 277
+ ++ + C ++ +W + S+T T+ + RA V F +++A+G+
Sbjct: 310 VLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGD 369
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 47.8 bits (112), Expect = 1e-05
Identities = 34/147 (23%), Positives = 65/147 (44%), Gaps = 19/147 (12%)
Query: 64 ESKKPVVTFQAHDGPVYSMVSTDRHLLSAG-DGEVKAWLWAEMLKKGCKELWRRQPPYRT 122
E++ + T Q H VYS+ H++S D ++ W ++ C +
Sbjct: 411 ETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVW---DVETGNCIHTLTGHQSLTS 467
Query: 123 SLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRG---HTDYIHCLALRER 179
+E+ K+N L+ D + D++TG + L+G H + CL +
Sbjct: 468 GMEL----------KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN 517
Query: 180 SPEVLSGGEDGAVRLWDLRTAKEVQTI 206
V++ +DG V+LWDL+T + ++ +
Sbjct: 518 F--VITSSDDGTVKLWDLKTGEFIRNL 542
Score = 46.2 bits (108), Expect = 3e-05
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 137 KENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
++N +I D L + ETG L GHT + C+ L E+ V+SG D +R+WD
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWD 369
Query: 197 LRTAK 201
+ T +
Sbjct: 370 IETGQ 374
Score = 42.0 bits (97), Expect = 6e-04
Identities = 25/104 (24%), Positives = 50/104 (48%), Gaps = 12/104 (11%)
Query: 147 DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
D + D+ETG L GH + L++ ++SG D V++WD++T + +QT+
Sbjct: 442 DTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTL 499
Query: 207 E-VYKHEECSRPHNGRWIGCLATDSDWMVCGGGP-ALTLWHLRS 248
+ KH+ + CL + ++++ + LW L++
Sbjct: 500 QGPNKHQSA--------VTCLQFNKNFVITSSDDGTVKLWDLKT 535
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 138 ENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDL 197
E ++ D L D+ETG VL GH + C+ R V+SG D V++WD
Sbjct: 353 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVWDP 410
Query: 198 RTAKEVQTIEVYKHEECSRPHNG 220
T + T++ + + S +G
Sbjct: 411 ETETCLHTLQGHTNRVYSLQFDG 433
Score = 32.7 bits (73), Expect = 0.39
Identities = 20/78 (25%), Positives = 34/78 (43%), Gaps = 4/78 (5%)
Query: 139 NSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLR 198
N ++ D L TG R L GHT + +R+ ++SG D +++W+
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNAE 331
Query: 199 TAKEVQTIEVYKHEECSR 216
T + + T+ Y H R
Sbjct: 332 TGECIHTL--YGHTSTVR 347
Score = 30.4 bits (67), Expect = 1.9
Identities = 13/45 (28%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
+VL+GH D++ L+ ++SG +D +++W T K ++T+
Sbjct: 256 KVLKGHDDHV-ITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL 299
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 47.8 bits (112), Expect = 1e-05
Identities = 34/147 (23%), Positives = 65/147 (44%), Gaps = 19/147 (12%)
Query: 64 ESKKPVVTFQAHDGPVYSMVSTDRHLLSAG-DGEVKAWLWAEMLKKGCKELWRRQPPYRT 122
E++ + T Q H VYS+ H++S D ++ W ++ C +
Sbjct: 529 ETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVW---DVETGNCIHTLTGHQSLTS 585
Query: 123 SLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRG---HTDYIHCLALRER 179
+E+ K+N L+ D + D++TG + L+G H + CL +
Sbjct: 586 GMEL----------KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN 635
Query: 180 SPEVLSGGEDGAVRLWDLRTAKEVQTI 206
V++ +DG V+LWDL+T + ++ +
Sbjct: 636 F--VITSSDDGTVKLWDLKTGEFIRNL 660
Score = 46.2 bits (108), Expect = 3e-05
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 137 KENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
++N +I D L + ETG L GHT + C+ L E+ V+SG D +R+WD
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWD 487
Query: 197 LRTAK 201
+ T +
Sbjct: 488 IETGQ 492
Score = 42.0 bits (97), Expect = 6e-04
Identities = 25/104 (24%), Positives = 50/104 (48%), Gaps = 12/104 (11%)
Query: 147 DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
D + D+ETG L GH + L++ ++SG D V++WD++T + +QT+
Sbjct: 560 DTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTL 617
Query: 207 E-VYKHEECSRPHNGRWIGCLATDSDWMVCGGGP-ALTLWHLRS 248
+ KH+ + CL + ++++ + LW L++
Sbjct: 618 QGPNKHQSA--------VTCLQFNKNFVITSSDDGTVKLWDLKT 653
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 138 ENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDL 197
E ++ D L D+ETG VL GH + C+ R V+SG D V++WD
Sbjct: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVWDP 528
Query: 198 RTAKEVQTIEVYKHEECSRPHNG 220
T + T++ + + S +G
Sbjct: 529 ETETCLHTLQGHTNRVYSLQFDG 551
Score = 32.7 bits (73), Expect = 0.39
Identities = 20/78 (25%), Positives = 34/78 (43%), Gaps = 4/78 (5%)
Query: 139 NSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLR 198
N ++ D L TG R L GHT + +R+ ++SG D +++W+
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNAE 449
Query: 199 TAKEVQTIEVYKHEECSR 216
T + + T+ Y H R
Sbjct: 450 TGECIHTL--YGHTSTVR 465
Score = 30.4 bits (67), Expect = 1.9
Identities = 13/45 (28%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 162 RVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTI 206
+VL+GH D++ L+ ++SG +D +++W T K ++T+
Sbjct: 374 KVLKGHDDHV-ITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL 417
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,194,342
Number of Sequences: 37866
Number of extensions: 537658
Number of successful extensions: 2058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 163
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 1243
Number of HSP's gapped (non-prelim): 823
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.