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Search of human proteins with 21361763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361763 hairy and enhancer of split 6 isoform a [Homo
sapiens]
(224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens] 450 e-127
gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens] 442 e-124
gi|5031763 hairy and enhancer of split 1 [Homo sapiens] 99 4e-21
gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens] 89 4e-18
gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens] 89 4e-18
gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens] 76 2e-14
gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i... 65 5e-11
gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i... 64 1e-10
gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho... 63 2e-10
gi|145207994 hairy and enhancer of split 7 [Homo sapiens] 55 4e-08
gi|58219048 hairy and enhancer of split 5 [Homo sapiens] 54 1e-07
gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ... 52 4e-07
gi|71274142 HES/HEY-like transcription factor [Homo sapiens] 50 2e-06
gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens] 48 8e-06
gi|66912172 hairy and enhancer of split 3 [Homo sapiens] 47 1e-05
gi|13540521 basic helix-loop-helix domain containing, class B, 3... 42 4e-04
gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens] 37 0.014
gi|116008152 alpha 1 type XV collagen precursor [Homo sapiens] 36 0.023
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] 36 0.030
gi|6912492 mitogen-activated protein kinase 8 interacting protei... 36 0.030
gi|7706537 mitogen-activated protein kinase 8 interacting protei... 36 0.030
gi|52630419 sterol regulatory element binding transcription fact... 35 0.040
gi|22547195 sterol regulatory element binding transcription fact... 35 0.040
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 35 0.040
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 35 0.040
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 35 0.040
gi|154355000 KH-type splicing regulatory protein [Homo sapiens] 35 0.040
gi|110556644 zinc finger protein, multitype 1 [Homo sapiens] 35 0.040
gi|169207312 PREDICTED: hypothetical protein [Homo sapiens] 35 0.052
gi|239750650 PREDICTED: hypothetical protein [Homo sapiens] 35 0.052
>gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]
Length = 224
Score = 450 bits (1158), Expect = e-127
Identities = 224/224 (100%), Positives = 224/224 (100%)
Query: 1 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK 60
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
Sbjct: 1 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK 60
Query: 61 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 120
LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
Sbjct: 61 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 120
Query: 121 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD 180
VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
Sbjct: 121 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD 180
Query: 181 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224
LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
Sbjct: 181 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224
>gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]
Length = 222
Score = 442 bits (1136), Expect = e-124
Identities = 222/224 (99%), Positives = 222/224 (99%), Gaps = 2/224 (0%)
Query: 1 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK 60
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAE AK
Sbjct: 1 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAE--AK 58
Query: 61 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 120
LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
Sbjct: 59 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 118
Query: 121 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD 180
VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
Sbjct: 119 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD 178
Query: 181 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224
LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
Sbjct: 179 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 222
>gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
Length = 280
Score = 98.6 bits (244), Expect = 4e-21
Identities = 75/247 (30%), Positives = 110/247 (44%), Gaps = 51/247 (20%)
Query: 26 RKARKPLVEKKRRARINESLQELRLLLAGA-----EVQAKLENAEVLELTVRRVQGVLRG 80
RK+ KP++EK+RRARINESL +L+ L+ A +KLE A++LE+TV+ ++ + R
Sbjct: 35 RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRA 94
Query: 81 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSS 140
+ ++ AG+ +CM+EV F+STC+ ++ V LL HL M +
Sbjct: 95 QMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMT 154
Query: 141 FQDLLGDALAGPPRAPGRSGWP-----AGGAPGSPIP--SPPGPGDDLCSDLEEAPEA-- 191
+ AL PP P G P A P PIP + P PG C +A EA
Sbjct: 155 YPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAK 214
Query: 192 -----ELSQAP-----------------------------AEGPDLVPAALGSLTTAQIA 217
++ AP + GP+ V + G TA
Sbjct: 215 VFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD-- 272
Query: 218 RSVWRPW 224
S+WRPW
Sbjct: 273 -SMWRPW 278
>gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]
Length = 247
Score = 88.6 bits (218), Expect = 4e-18
Identities = 69/228 (30%), Positives = 102/228 (44%), Gaps = 33/228 (14%)
Query: 7 PG-RDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA-----EVQAK 60
PG R G + G + D ++ KP++EK+RRARINESL +L+ L+ A +K
Sbjct: 41 PGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSK 100
Query: 61 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 120
LE A++LE+TVR ++ + R + ++ AG+ +C+ EV+ F++ C+ + A
Sbjct: 101 LEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD 160
Query: 121 VAAELLNHLLESM----PLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPG 176
V + LL HL + P R +S P AP + P A +PS G
Sbjct: 161 VRSRLLGHLAACLRQLGPSRRPASLS----------PAAPAEAPAPEVYAGRPLLPSLGG 210
Query: 177 PGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224
P L L L AP GP Q WRPW
Sbjct: 211 PFPLLAPPLLPGLTRALPAAPRAGP-------------QGPGGPWRPW 245
>gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]
Length = 221
Score = 88.6 bits (218), Expect = 4e-18
Identities = 69/232 (29%), Positives = 100/232 (43%), Gaps = 32/232 (13%)
Query: 2 APPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA-----E 56
A P A R + RK+ KP++EK+RRARINESL +L+ L+ A
Sbjct: 11 ASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKESS 70
Query: 57 VQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQA 116
+KLE A++LE+TVR ++ + R + ++ AG+ +C+ EV+ F++ C+
Sbjct: 71 RHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEG 130
Query: 117 IDATVAAELLNHLLESM----PLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIP 172
+ A V + LL HL + P R +S P AP + P A +P
Sbjct: 131 VPADVRSRLLGHLAACLRQLGPSRRPASLS----------PAAPAEAPAPEVYAGRPLLP 180
Query: 173 SPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224
S GP L L L AP GP Q WRPW
Sbjct: 181 SLGGPFPLLAPPLLPGLTRALPAAPRAGP-------------QGPGGPWRPW 219
>gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]
Length = 173
Score = 76.3 bits (186), Expect = 2e-14
Identities = 56/159 (35%), Positives = 83/159 (52%), Gaps = 16/159 (10%)
Query: 26 RKARKPLVEKKRRARINESLQELR---LLLAGAEVQ--AKLENAEVLELTVRRVQGVLRG 80
RK+ KPL+EK+RRARIN+SL +L+ L L G E +KLE A+VLE+TVR +Q +
Sbjct: 14 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPAS 73
Query: 81 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLE--SMPLREG 138
L ++ + GY C+ + + C+ ++ V+A LL HL + +G
Sbjct: 74 SWPTAAPLPCDS---YREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDG 130
Query: 139 SSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGP 177
D G + P AP + PA +P+PSPP P
Sbjct: 131 GRAGDSSGPSAPAP--APASAPEPA----SAPVPSPPSP 163
>gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
isoform a [Homo sapiens]
Length = 304
Score = 65.1 bits (157), Expect = 5e-11
Identities = 58/194 (29%), Positives = 89/194 (45%), Gaps = 14/194 (7%)
Query: 26 RKARKPLVEKKRRARINESLQELRLLLAGA---EVQAKLENAEVLELTVRRVQGVLRGRA 82
RK R+ ++EK+RR RIN SL ELR L+ A + AKLE AE+L++TV ++ +
Sbjct: 50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
Query: 83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLREGSS 140
+ A A + + G+ +C+ EV ++S + +DA+ + L++HL RE +S
Sbjct: 110 KGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAAS 169
Query: 141 FQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAELSQAP 197
A AG P + + P+ P G S E + L A
Sbjct: 170 ------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAH 223
Query: 198 AEGPDLVPAALGSL 211
E P L GSL
Sbjct: 224 PEAPALRAPPSGSL 237
>gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
isoform b [Homo sapiens]
Length = 308
Score = 63.5 bits (153), Expect = 1e-10
Identities = 58/198 (29%), Positives = 89/198 (44%), Gaps = 18/198 (9%)
Query: 26 RKARKPLVEKKRRARINESLQELRLLLAGA-------EVQAKLENAEVLELTVRRVQGVL 78
RK R+ ++EK+RR RIN SL ELR L+ A + AKLE AE+L++TV ++ +
Sbjct: 50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH 109
Query: 79 RGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLR 136
+ A A + + G+ +C+ EV ++S + +DA+ + L++HL R
Sbjct: 110 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQR 169
Query: 137 EGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAEL 193
E +S A AG P + + P+ P G S E + L
Sbjct: 170 EAAS------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRL 223
Query: 194 SQAPAEGPDLVPAALGSL 211
A E P L GSL
Sbjct: 224 GSAHPEAPALRAPPSGSL 241
>gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo
sapiens]
Length = 337
Score = 63.2 bits (152), Expect = 2e-10
Identities = 39/120 (32%), Positives = 69/120 (57%), Gaps = 5/120 (4%)
Query: 26 RKARKPLVEKKRRARINESLQELRLLLAGA---EVQAKLENAEVLELTVRRVQGVLRGRA 82
RK R+ ++EK+RR RIN SL ELR L+ A + AKLE AE+L++TV ++ +
Sbjct: 49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGG 108
Query: 83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLREGSS 140
+ A A + + G+ +C+ EV ++S+ + +D++ + L++HL RE ++
Sbjct: 109 KGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAA 168
>gi|145207994 hairy and enhancer of split 7 [Homo sapiens]
Length = 225
Score = 55.5 bits (132), Expect = 4e-08
Identities = 75/250 (30%), Positives = 92/250 (36%), Gaps = 73/250 (29%)
Query: 18 DGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAE-----VQAKLENAEVLELTVR 72
D E R K KPLVEK+RR RIN SL+ELRLLL KLE AE+LE V
Sbjct: 5 DRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAV- 63
Query: 73 RVQGVLRGRAR------EREQLQ-AEA-SERFAAGYIQCMHEVHTFVSTCQAIDATVAAE 124
G LR R+R R +Q AEA + + +G+ +C+ + F
Sbjct: 64 ---GYLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFS 120
Query: 125 LLNHLLESMPLREG-------------SSFQDLLGDAL-AGPPRAPG----RSGW----- 161
L+ L P R LG AL PP G R W
Sbjct: 121 ALHGYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLC 180
Query: 162 -PAGGAPGSP------IPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTA 214
P G G+P +P PP P + AP+A L PA
Sbjct: 181 SPRAGDSGAPAPLTGLLPPPPPPHRQ-----DGAPKAPLPPPPA---------------- 219
Query: 215 QIARSVWRPW 224
WRPW
Sbjct: 220 -----FWRPW 224
>gi|58219048 hairy and enhancer of split 5 [Homo sapiens]
Length = 166
Score = 53.9 bits (128), Expect = 1e-07
Identities = 56/202 (27%), Positives = 81/202 (40%), Gaps = 57/202 (28%)
Query: 27 KARKPLVEKKRRARINESLQELRLLL----AGAEVQAKLENAEVLELTVRRVQGVLRGRA 82
+ RKP+VEK RR RIN S+++L+LLL A + +KLE A++LE+ V ++ +A
Sbjct: 18 RLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLK---HSKA 74
Query: 83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQ 142
+ ++ GY C+ E F++ A D + +LL H FQ
Sbjct: 75 FVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQM--KLLYH------------FQ 120
Query: 143 DLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPD 202
PP AP +P P PG AP LS
Sbjct: 121 --------RPP-----------AAPAAPAKEPKAPG--------AAPPPALS-------- 145
Query: 203 LVPAALGSLTTAQIARSVWRPW 224
A + Q A +WRPW
Sbjct: 146 -AKATAAAAAAHQPACGLWRPW 166
>gi|7657154 hairy/enhancer-of-split related with YRPW motif-like
[Homo sapiens]
Length = 328
Score = 52.0 bits (123), Expect = 4e-07
Identities = 37/110 (33%), Positives = 60/110 (54%), Gaps = 6/110 (5%)
Query: 26 RKARKPLVEKKRRARINESLQELRLLLAGA---EVQAKLENAEVLELTVRRVQGVLRGRA 82
RK R+ ++EK+RR RIN SL ELR L+ A + +KLE AEVL++TV ++ +
Sbjct: 44 RKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGG 103
Query: 83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDA---TVAAELLNHL 129
+A A + + G+ +C+ EV ++ + + V LL+HL
Sbjct: 104 TGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHL 153
>gi|71274142 HES/HEY-like transcription factor [Homo sapiens]
Length = 327
Score = 50.1 bits (118), Expect = 2e-06
Identities = 63/249 (25%), Positives = 92/249 (36%), Gaps = 66/249 (26%)
Query: 21 ETRGDRKARKPLVEKKRRARINESLQEL--------------------------RLLLAG 54
E+R ++EK+RR RIN L EL L+L+
Sbjct: 50 ESRVRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQGEPQEALAQIRSRVRSLVLSS 109
Query: 55 AEV------------------QAKLENAEVLELTVRRVQGVLRG---RAREREQLQAEAS 93
A V KLE AE+LE+TV+ ++ + R RE+ +L AE +
Sbjct: 110 ATVPDQQALGRCEGPFLLLQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFA 169
Query: 94 ERFAAGYIQCMHEVHTFVSTCQAID----------------ATVAAELLNHLLESMPLRE 137
F GY +CM + +++T + ++ A + AE L S+P +
Sbjct: 170 NYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGAEPAFPPLGSLPEPD 229
Query: 138 GSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPG-DDLCSDLEEAPEAELSQA 196
S G AG +PG + G+ P P PPG L AP S A
Sbjct: 230 FSYQLHPAGPEFAG--HSPGEAAVFPQGSGAGPFPWPPGAARSPALPYLPSAPVPLASPA 287
Query: 197 PAEGPDLVP 205
P L P
Sbjct: 288 QQHSPFLTP 296
>gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]
Length = 412
Score = 47.8 bits (112), Expect = 8e-06
Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 30/184 (16%)
Query: 14 REDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLL---AGAEVQAKLENAEVLELT 70
+ ED ET K L+EKKRR RINE + +L+ LL LE A VLELT
Sbjct: 44 KRSEDSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELT 100
Query: 71 VRRVQGVLRGRAREREQLQAEAS----------------ERFAAGYIQCMHEVHTFVSTC 114
++ V+ + ++++++ A S E F +G+ C EV +++
Sbjct: 101 LKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKH 160
Query: 115 QAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSP 174
+ +++L+ HL + +LL + P P P SP
Sbjct: 161 ENTRDLKSSQLVTHLHRVV--------SELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGS 212
Query: 175 PGPG 178
GPG
Sbjct: 213 EGPG 216
>gi|66912172 hairy and enhancer of split 3 [Homo sapiens]
Length = 186
Score = 47.0 bits (110), Expect = 1e-05
Identities = 57/202 (28%), Positives = 84/202 (41%), Gaps = 34/202 (16%)
Query: 33 VEKKRRARINESLQELRLLL----AGAEVQAKLENAEVLELTV---RRVQGVLRGR---A 82
+EKKRRARIN SL++L+ LL + + KLE A++LEL+V R +Q L+G
Sbjct: 1 MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVP 60
Query: 83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQ 142
R EQ +G+ C+ V + + + + L+ + Q
Sbjct: 61 RGAEQ---------PSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQ 111
Query: 143 DLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPD 202
+ AL P + PA G P SP P L PE+ L + A P
Sbjct: 112 E--APALFRPCTPAVWAPAPAAGGPRSPPP------------LLLLPES-LPGSSASVPP 156
Query: 203 LVPAALGSLTTAQIARSVWRPW 224
PA+ + + VWRPW
Sbjct: 157 PQPASSRCAESPGLGLRVWRPW 178
>gi|13540521 basic helix-loop-helix domain containing, class B, 3
[Homo sapiens]
Length = 482
Score = 42.0 bits (97), Expect = 4e-04
Identities = 42/162 (25%), Positives = 71/162 (43%), Gaps = 32/162 (19%)
Query: 21 ETRGDRKARKPLVEKKRRARINESLQELRLLL---AGAEVQAKLENAEVLELTVRRVQGV 77
+T+ K L+EKKRR RINE + +L+ LL LE A VLELT++ ++ +
Sbjct: 40 DTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKAL 99
Query: 78 LRGRAREREQLQA-EASER------------FAAGYIQCMHEVHTFVSTCQAIDATV--A 122
++ +++ A + ER F +G+ C EV ++S ++
Sbjct: 100 TALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRC 159
Query: 123 AELLNH--------------LLESMPLREGSSFQDLLGDALA 150
+L+NH L + +PL +G+ G A A
Sbjct: 160 VQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAA 201
>gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens]
Length = 1729
Score = 37.0 bits (84), Expect = 0.014
Identities = 25/61 (40%), Positives = 27/61 (44%), Gaps = 3/61 (4%)
Query: 151 GPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQA---PAEGPDLVPAA 207
G P +PG +G PGSP PP S L EA E SQA PA P AA
Sbjct: 283 GGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAA 342
Query: 208 L 208
L
Sbjct: 343 L 343
>gi|116008152 alpha 1 type XV collagen precursor [Homo sapiens]
Length = 1388
Score = 36.2 bits (82), Expect = 0.023
Identities = 17/28 (60%), Positives = 17/28 (60%), Gaps = 1/28 (3%)
Query: 151 GPPRAPGRSGWPAGGAPGSP-IPSPPGP 177
GPP APG G P G PG P P PPGP
Sbjct: 1076 GPPGAPGLPGPPGFGRPGDPGPPGPPGP 1103
Score = 31.6 bits (70), Expect = 0.57
Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 2/32 (6%)
Query: 149 LAGPPRAPGRSGWP-AGGAPGSP-IPSPPGPG 178
L GPP G++G P G PG P P PPGPG
Sbjct: 701 LPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPG 732
Score = 29.6 bits (65), Expect = 2.2
Identities = 28/79 (35%), Positives = 32/79 (40%), Gaps = 16/79 (20%)
Query: 138 GSSFQDLLGDALA-----GPPRAPGRSGWPAGGAPGSPI-PSPPG-PGDDLCSDLEEAPE 190
GS DL+G GPP PG G P G PG+ + PPG PG+D P
Sbjct: 604 GSGSGDLVGSEQLLRGPPGPPGPPGLPGIP--GKPGTDVFMGPPGSPGED-------GPA 654
Query: 191 AELSQAPAEGPDLVPAALG 209
E EG V A G
Sbjct: 655 GEPGPPGPEGQPGVDGATG 673
>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
Length = 1838
Score = 35.8 bits (81), Expect = 0.030
Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 151 GPPRAPGRSGWPAG-----GAPGSPIPS-PPGPGDDLCSDLEEAPEAELSQAPAEGPDLV 204
GP +PG G PAG G PG P P PPGP + + E+ P+ + +GP +
Sbjct: 1084 GPAGSPGERG-PAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGL 1142
Query: 205 PAALG 209
P G
Sbjct: 1143 PGPAG 1147
Score = 32.0 bits (71), Expect = 0.44
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 142 QDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGP 177
QD + + + GP G+ G PA PG I PPGP
Sbjct: 438 QDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGP 473
Score = 29.6 bits (65), Expect = 2.2
Identities = 23/73 (31%), Positives = 31/73 (42%), Gaps = 4/73 (5%)
Query: 150 AGPPRAPGRSGWPAG--GAPGSP-IPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPA 206
+GP G +G P+G G PG P +P PPGP S P+ E GP P
Sbjct: 1512 SGPKGEQGITG-PSGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPG 1570
Query: 207 ALGSLTTAQIARS 219
+ Q +R+
Sbjct: 1571 EVIQPLPIQASRT 1583
>gi|6912492 mitogen-activated protein kinase 8 interacting protein 2
isoform 1 [Homo sapiens]
Length = 824
Score = 35.8 bits (81), Expect = 0.030
Identities = 30/81 (37%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 125 LLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGA--PGSPIPSPPGPGDDLC 182
LL++L+ M + EGSS G L+ PR PG PAGGA + GPG
Sbjct: 350 LLSNLVSRM-ISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVEL 408
Query: 183 SDLEE--APEAELSQAPAEGP 201
D+E AP AP GP
Sbjct: 409 VDMETLCAPPPPAPAAPRPGP 429
>gi|7706537 mitogen-activated protein kinase 8 interacting protein 2
isoform 2 [Homo sapiens]
Length = 797
Score = 35.8 bits (81), Expect = 0.030
Identities = 30/81 (37%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 125 LLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGA--PGSPIPSPPGPGDDLC 182
LL++L+ M + EGSS G L+ PR PG PAGGA + GPG
Sbjct: 323 LLSNLVSRM-ISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVEL 381
Query: 183 SDLEE--APEAELSQAPAEGP 201
D+E AP AP GP
Sbjct: 382 VDMETLCAPPPPAPAAPRPGP 402
>gi|52630419 sterol regulatory element binding transcription factor
1 isoform a [Homo sapiens]
Length = 1177
Score = 35.4 bits (80), Expect = 0.040
Identities = 41/157 (26%), Positives = 66/157 (42%), Gaps = 18/157 (11%)
Query: 21 ETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRG 80
++RG+++ +EK+ R+ IN+ + EL+ L+ G E AKL + VL R+ +R
Sbjct: 349 QSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTE--AKLNKSAVL----RKAIDYIRF 402
Query: 81 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT------VAAELLNHLLESMP 134
++L+ E A + + VS C + T V E + L P
Sbjct: 403 LQHSNQKLKQENLSLRTA--VHKSKSLKDLVSACGSGGNTDVLMEGVKTE-VEDTLTPPP 459
Query: 135 LREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPI 171
GS FQ L+ R G G + P SP+
Sbjct: 460 SDAGSPFQ---SSPLSLGSRGSGSGGSGSDSEPDSPV 493
>gi|22547195 sterol regulatory element binding transcription factor
1 isoform b [Homo sapiens]
Length = 1147
Score = 35.4 bits (80), Expect = 0.040
Identities = 41/157 (26%), Positives = 66/157 (42%), Gaps = 18/157 (11%)
Query: 21 ETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRG 80
++RG+++ +EK+ R+ IN+ + EL+ L+ G E AKL + VL R+ +R
Sbjct: 319 QSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTE--AKLNKSAVL----RKAIDYIRF 372
Query: 81 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT------VAAELLNHLLESMP 134
++L+ E A + + VS C + T V E + L P
Sbjct: 373 LQHSNQKLKQENLSLRTA--VHKSKSLKDLVSACGSGGNTDVLMEGVKTE-VEDTLTPPP 429
Query: 135 LREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPI 171
GS FQ L+ R G G + P SP+
Sbjct: 430 SDAGSPFQ---SSPLSLGSRGSGSGGSGSDSEPDSPV 463
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 35.4 bits (80), Expect = 0.040
Identities = 31/87 (35%), Positives = 36/87 (41%), Gaps = 18/87 (20%)
Query: 146 GDALAGPP-----RAPGRSGWPAG--------GAPGSPIPSPP--GPG--DDLCSDLE-E 187
G A A PP A + W G GAPG+P+P PP GPG D LC+ E E
Sbjct: 651 GGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 710
Query: 188 APEAELSQAPAEGPDLVPAALGSLTTA 214
PE+ A P P G A
Sbjct: 711 GPESATPAPGALDPGPSPGTSGGKAAA 737
Score = 28.5 bits (62), Expect = 4.9
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 5/57 (8%)
Query: 152 PPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEA---ELSQAPAEGPDLVP 205
PP+AP P AP SP SP P L + +AP A L QAP P P
Sbjct: 393 PPQAPPALALPPLQAPPSPPASP--PLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 447
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 35.4 bits (80), Expect = 0.040
Identities = 31/87 (35%), Positives = 36/87 (41%), Gaps = 18/87 (20%)
Query: 146 GDALAGPP-----RAPGRSGWPAG--------GAPGSPIPSPP--GPG--DDLCSDLE-E 187
G A A PP A + W G GAPG+P+P PP GPG D LC+ E E
Sbjct: 920 GGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 979
Query: 188 APEAELSQAPAEGPDLVPAALGSLTTA 214
PE+ A P P G A
Sbjct: 980 GPESATPAPGALDPGPSPGTSGGKAAA 1006
Score = 28.5 bits (62), Expect = 4.9
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 5/57 (8%)
Query: 152 PPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEA---ELSQAPAEGPDLVP 205
PP+AP P AP SP SP P L + +AP A L QAP P P
Sbjct: 618 PPQAPPXLALPPLQAPPSPPASP--PLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 672
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 35.4 bits (80), Expect = 0.040
Identities = 31/87 (35%), Positives = 36/87 (41%), Gaps = 18/87 (20%)
Query: 146 GDALAGPP-----RAPGRSGWPAG--------GAPGSPIPSPP--GPG--DDLCSDLE-E 187
G A A PP A + W G GAPG+P+P PP GPG D LC+ E E
Sbjct: 612 GGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 671
Query: 188 APEAELSQAPAEGPDLVPAALGSLTTA 214
PE+ A P P G A
Sbjct: 672 GPESATPAPGALDPGPSPGTSGGKAAA 698
Score = 28.5 bits (62), Expect = 4.9
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 5/57 (8%)
Query: 152 PPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEA---ELSQAPAEGPDLVP 205
PP+AP P AP SP SP P L + +AP A L QAP P P
Sbjct: 354 PPQAPPALALPPLQAPPSPPASP--PLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 408
>gi|154355000 KH-type splicing regulatory protein [Homo sapiens]
Length = 711
Score = 35.4 bits (80), Expect = 0.040
Identities = 17/29 (58%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Query: 151 GPPRAPGRSGWPAGGAPGSPIPSPPGPGD 179
GPP P G AGGA G P P PPG GD
Sbjct: 12 GPP-PPAGGGGGAGGAGGGPPPGPPGAGD 39
Score = 28.1 bits (61), Expect = 6.3
Identities = 16/37 (43%), Positives = 17/37 (45%), Gaps = 3/37 (8%)
Query: 143 DLLGDALAGPPRAPGRSGWPAGG---APGSPIPSPPG 176
DLL +GPP PG G P GG G PPG
Sbjct: 388 DLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPG 424
>gi|110556644 zinc finger protein, multitype 1 [Homo sapiens]
Length = 1006
Score = 35.4 bits (80), Expect = 0.040
Identities = 31/81 (38%), Positives = 35/81 (43%), Gaps = 9/81 (11%)
Query: 129 LLESMPLREGSSFQDLLGDALAGP---PRAPGRSG-WPAGGAPGSPIPSPPGPGDDLCSD 184
LLE L G LLG LAGP R P G PA SP P GP D L +
Sbjct: 869 LLEHFRLAHGL----LLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGLGPE 924
Query: 185 LEEAPEAELSQAPAEGPDLVP 205
+E P +PA P+ VP
Sbjct: 925 PQEPPPGP-PPSPAAAPEAVP 944
Score = 31.2 bits (69), Expect = 0.75
Identities = 21/57 (36%), Positives = 23/57 (40%), Gaps = 8/57 (14%)
Query: 150 AGPPRAPG--------RSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPA 198
A PP PG R G +G PG PGP D DL + P L APA
Sbjct: 754 APPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPA 810
>gi|169207312 PREDICTED: hypothetical protein [Homo sapiens]
Length = 414
Score = 35.0 bits (79), Expect = 0.052
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 153 PRAPGRSGWPAGGAPGSPIPSP----PGPGDDLCSDLEEAPEAELS--QAPAEGPDLVPA 206
P P + WPA GAPG+P P+ PGP S +E ++ + EG +L P+
Sbjct: 322 PAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRRDEPRRVVIAARECGREGSELPPS 381
>gi|239750650 PREDICTED: hypothetical protein [Homo sapiens]
Length = 414
Score = 35.0 bits (79), Expect = 0.052
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 153 PRAPGRSGWPAGGAPGSPIPSP----PGPGDDLCSDLEEAPEAELS--QAPAEGPDLVPA 206
P P + WPA GAPG+P P+ PGP S +E ++ + EG +L P+
Sbjct: 322 PAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRRDEPRRVVIAARECGREGSELPPS 381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,412,763
Number of Sequences: 37866
Number of extensions: 618138
Number of successful extensions: 5721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 401
Number of HSP's that attempted gapping in prelim test: 4458
Number of HSP's gapped (non-prelim): 1651
length of query: 224
length of database: 18,247,518
effective HSP length: 98
effective length of query: 126
effective length of database: 14,536,650
effective search space: 1831617900
effective search space used: 1831617900
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.