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Search of human proteins with 11415052
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11415052 retinoid X receptor, beta [Homo sapiens]
(533 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11415052 retinoid X receptor, beta [Homo sapiens] 1112 0.0
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 627 e-179
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 579 e-165
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 284 1e-76
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 272 6e-73
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 269 4e-72
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 268 1e-71
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 261 9e-70
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 261 9e-70
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 261 9e-70
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 261 9e-70
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 260 3e-69
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 260 3e-69
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 216 3e-56
gi|238550159 estrogen-related receptor beta [Homo sapiens] 212 6e-55
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 209 4e-54
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 209 4e-54
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 209 4e-54
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 209 4e-54
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 207 3e-53
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 206 4e-53
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 205 1e-52
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 203 4e-52
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 202 5e-52
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 202 6e-52
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 200 3e-51
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 200 3e-51
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 188 9e-48
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 188 9e-48
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 188 9e-48
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 1112 bits (2876), Expect = 0.0
Identities = 533/533 (100%), Positives = 533/533 (100%)
Query: 1 MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT 60
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
Sbjct: 1 MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT 60
Query: 61 PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP 120
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
Sbjct: 61 PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP 120
Query: 121 PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK 180
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
Sbjct: 121 PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK 180
Query: 181 PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS 240
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
Sbjct: 181 PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS 240
Query: 241 CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP 300
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
Sbjct: 241 CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP 300
Query: 301 VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF 360
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
Sbjct: 301 VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF 360
Query: 361 SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV 420
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
Sbjct: 361 SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV 420
Query: 421 LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP 480
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
Sbjct: 421 LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP 480
Query: 481 EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA 533
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
Sbjct: 481 EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA 533
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 627 bits (1616), Expect = e-179
Identities = 332/461 (72%), Positives = 362/461 (78%), Gaps = 19/461 (4%)
Query: 80 SRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPP----PMPPPPLGSPFPV 135
S +SS +P +G S P L PS P +G G P P +G PF V
Sbjct: 12 STQVNSSLTSPTGRG----SMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSV 67
Query: 136 ISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRG-LHCPPP 194
ISS MG + P P SPQ++S ++ P S ED+KPP LG+ G L P
Sbjct: 68 ISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMN-PVSSS---EDIKPP-LGLNGVLKVPAH 122
Query: 195 PGGPGAG--KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKR 252
P G A K +CAICGDRSSGKHYGVYSCEGCKGFFKRT+RKDLTY+CRDNKDC +DKR
Sbjct: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
Query: 253 QRNRCQYCRYQKCLATGMKREAVQEERQRGKDK-DGDGEGAGGAPEEMPVDRILEAELAV 311
QRNRCQYCRYQKCLA GMKREAVQEERQRGKD+ + + E A E+MPV+RILEAELAV
Sbjct: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E K++ VE G + SSPNDPVTNICQAADKQLFTLVEWAKRIPHFS LPLDDQVIL
Sbjct: 243 EPKTETYVEA--NMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
LRAGWNELLIASFSHRSI V+DGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
Sbjct: 301 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+MDKTELGCLRAI+LFNPD+KGLSNP+EVE LREKVYASLE YCK KYPEQ GRFAKLLL
Sbjct: 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQL 532
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQ+
Sbjct: 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQM 461
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 579 bits (1493), Expect = e-165
Identities = 311/464 (67%), Positives = 352/464 (75%), Gaps = 26/464 (5%)
Query: 74 GDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPF 133
G +G S SP ++ P P P P T ++G P LGSP+
Sbjct: 20 GHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG---------TPLNALGSPY 70
Query: 134 PVISSSMGSPGLPPPAPPGFS--GPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGL-H 190
VI+S+MG P APPG + P SS Q+N S+ ED+KP + G+ G+ +
Sbjct: 71 RVITSAMGPPSGALAAPPGINLVAPPSS-QLNVVNSVSSS-----EDIKP-LPGLPGIGN 123
Query: 191 CPPPPGGPGA-GKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTV 249
P PG+ K +CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDL Y+CRDNKDC +
Sbjct: 124 MNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLI 183
Query: 250 DKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDK-DGDGEGAGGAPEEMPVDRILEAE 308
DKRQRNRCQYCRYQKCL GMKREAVQEERQR +++ + + E A E+MPV+RILEAE
Sbjct: 184 DKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAE 243
Query: 309 LAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQ 368
LAVE K++ G +S NDPVTNIC AADKQLFTLVEWAKRIPHFS L L+DQ
Sbjct: 244 LAVEPKTESY-----GDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQ 298
Query: 369 VILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKM 428
VILLRAGWNELLIASFSHRS+ V+DGILLATGLHVHR+SAHSAGVG+IFDRVLTELVSKM
Sbjct: 299 VILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKM 358
Query: 429 RDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAK 488
+DM+MDK+ELGCLRAI+LFNPDAKGLSNPSEVE LREKVYA+LE Y KQKYPEQ GRFAK
Sbjct: 359 KDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAK 418
Query: 489 LLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQL 532
LLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE P Q+
Sbjct: 419 LLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQI 462
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 284 bits (727), Expect = 1e-76
Identities = 164/433 (37%), Positives = 231/433 (53%), Gaps = 55/433 (12%)
Query: 106 PPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINST 165
P P GS A PP+P PP G+P P PG GP S+P
Sbjct: 11 PQDEVPGSQGSQASQAPPVPGPPPGAPHT-------------PQTPGQGGPASTP----- 52
Query: 166 VSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRL------CAICGDRSSGKHYGV 219
GG G P GGPG+ K+ C +CGD+SSGKHYG
Sbjct: 53 AQTAAGGQGGP-------------------GGPGSDKQQQQQHIECVVCGDKSSGKHYGQ 93
Query: 220 YSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEER 279
++CEGCK FFKR++R++L+Y+CR N++C +D+ RN+CQYCR +KCL GM+REAVQ R
Sbjct: 94 FTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGR 153
Query: 280 QRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDP---- 335
+ G+ A + + L +++ +++ P T GS P
Sbjct: 154 M-PPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAE-----PYPTSRFGSQCMQPNNIM 207
Query: 336 -VTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDG 394
+ NIC+ A + LF+ VEWA+ IP F L + DQV LLR W+EL + + + S+ +
Sbjct: 208 GIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVA 267
Query: 395 -ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKG 453
+L A GLH SA R+ E V K++ + +D E CL+AI+LF DA G
Sbjct: 268 PLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACG 327
Query: 454 LSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLI 513
LS+ + VE L+EK +LE Y + +YP Q RF KLLLRLP+LR++ +E LFF +L+
Sbjct: 328 LSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLV 387
Query: 514 GDTPIDTFLMEML 526
G TPI+T + +ML
Sbjct: 388 GKTPIETLIRDML 400
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 272 bits (695), Expect = 6e-73
Identities = 153/396 (38%), Positives = 221/396 (55%), Gaps = 16/396 (4%)
Query: 141 GSPGLPPPAPP---GFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGG 197
G+PG P PA G G Q + P P + P G G PPG
Sbjct: 18 GNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGS 77
Query: 198 PGAGKRL-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNR 256
+ + + C +CGD+SSGKHYG ++CEGCK FFKR++R++LTY+CR N++C +D+ RN+
Sbjct: 78 GQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQ 137
Query: 257 CQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSD 316
CQYCR +KCL GM+REAVQ R + G+ A + + L +++ +++
Sbjct: 138 CQYCRLKKCLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAE 196
Query: 317 QGVEGPGGTGGSGSSPNDP-----VTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
P T GS P + NIC+ A + LF+ VEWA+ IP F L + DQV L
Sbjct: 197 -----PYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSL 251
Query: 372 LRAGWNELLIASFSHRSIDVRDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 430
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 252 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 311
Query: 431 MRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLL 490
+ +D E CL+AI+LF DA GLS+ + +E L+EK +LE Y + +YP Q RF KLL
Sbjct: 312 LHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLL 371
Query: 491 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 526
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 372 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
Score = 38.5 bits (88), Expect = 0.015
Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 12/80 (15%)
Query: 42 WLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPP 101
W DP VAGG P P +A R G G +G + S +P+ P P
Sbjct: 8 WRDPQDD----VAGGNPGGPNPA-AQAARGGGGGAGEQQQQAGSGAPHT-------PQTP 55
Query: 102 GPPLPPSTAPSLGGSGAPPP 121
G P P+T + G G PP
Sbjct: 56 GQPGAPATPGTAGDKGQGPP 75
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 269 bits (688), Expect = 4e-72
Identities = 138/337 (40%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQK 264
C +CGD+SSGKHYGV++CEGCK FFKR+IR++L+Y+CR N+DC +D+ RN+CQYCR +K
Sbjct: 56 CVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKK 115
Query: 265 CLATGMKREAVQEERQRGKDKDGDGEGAGGAPEE--------------MPVDRILEAELA 310
C GM++EAVQ R +G P PV ++ L
Sbjct: 116 CFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLR 175
Query: 311 VEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVI 370
E G G GG + + N+C+ A + LF+ VEWA+ P F LP+ DQV
Sbjct: 176 AEPY--PAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVA 233
Query: 371 LLRAGWNELLIASFSHRSIDVRDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMR 429
LLR W+EL + + + ++ + +L A GLH +A A R E V K+
Sbjct: 234 LLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLG 293
Query: 430 DMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKL 489
+++D E GCL+AI LF PDA GLS+P+ VE L+EK +L Y + +YP Q RF +L
Sbjct: 294 RLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRL 353
Query: 490 LLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 526
LLRLPALR++ + LFF +L+G TPI+T + +ML
Sbjct: 354 LLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 268 bits (684), Expect = 1e-71
Identities = 142/323 (43%), Positives = 200/323 (61%), Gaps = 8/323 (2%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R+IRK YSCR ++ C VDK +RN+C+YCR +
Sbjct: 48 LCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLR 107
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPG 323
KC GMK+EAVQ ER R + +G+ P ++ + +AE+ Q S V PG
Sbjct: 108 KCFRAGMKKEAVQNERDRISTRRSTFDGS-NIPS---INTLAQAEVRSRQIS---VSSPG 160
Query: 324 GTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIAS 383
+ + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L+
Sbjct: 161 SSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 220
Query: 384 FSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRA 443
+ RS+ +D +LL +HRNS + + +RVL ELV +++++D E CL+A
Sbjct: 221 ATKRSMMYKDILLLGNNYVIHRNSC-EVEISRVANRVLDELVRPFQEIQIDDNEYACLKA 279
Query: 444 IILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKC 503
I+ F+PDAKGLS+P +++ +R +V LE Y + + +GRF +LLL LP L+SI +
Sbjct: 280 IVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQM 339
Query: 504 LEHLFFFKLIGDTPIDTFLMEML 526
+E + F KL G ID L EML
Sbjct: 340 IEQIQFVKLFGMVKIDNLLQEML 362
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 261 bits (668), Expect = 9e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 168
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 169 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 228
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 229 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 288
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 289 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 348
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
+ +E + F KL G ID L EML +APH
Sbjct: 349 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 261 bits (668), Expect = 9e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 168
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 169 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 228
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 229 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 288
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 289 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 348
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
+ +E + F KL G ID L EML +APH
Sbjct: 349 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 261 bits (668), Expect = 9e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 97 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 146
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 147 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 206
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 207 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 266
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 267 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 326
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
+ +E + F KL G ID L EML +APH
Sbjct: 327 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 261 bits (668), Expect = 9e-70
Identities = 144/336 (42%), Positives = 204/336 (60%), Gaps = 19/336 (5%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 97 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 146
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 147 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 206
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 207 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 266
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 267 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 326
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPH 530
+ +E + F KL G ID L EML +APH
Sbjct: 327 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 260 bits (664), Expect = 3e-69
Identities = 141/326 (43%), Positives = 200/326 (61%), Gaps = 13/326 (3%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 168
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 169 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 228
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 229 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 288
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 289 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 348
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML 526
+ +E + F KL G ID L EML
Sbjct: 349 WQMIEQIQFIKLFGMAKIDNLLQEML 374
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 260 bits (664), Expect = 3e-69
Identities = 141/326 (43%), Positives = 200/326 (61%), Gaps = 13/326 (3%)
Query: 204 LCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQ 263
LCAICGDR++GKHYG SC+GCKGFF+R++RK+ YSCR ++ C VDK +RN+C+YCR +
Sbjct: 37 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 96
Query: 264 KCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGP 322
KC GMK+EAVQ ER R + E + +P ++ +L+AE+ Q + P
Sbjct: 97 KCFRAGMKKEAVQNERDRISTRRSSYEDSS-----LPSINALLQAEVLSRQ-----ITSP 146
Query: 323 --GGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380
G G + + ++C++ +QL LVEWAK IP F LPLDDQV LLRA E L
Sbjct: 147 VSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 206
Query: 381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGC 440
+ + RS+ +D +LL V R+ A + + R+L ELV +++++D E
Sbjct: 207 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY 266
Query: 441 LRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIG 500
L+AII F+PDAKGLS+P +++ LR +V SLE Y + + +GRF +LLL LP L+SI
Sbjct: 267 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT 326
Query: 501 LKCLEHLFFFKLIGDTPIDTFLMEML 526
+ +E + F KL G ID L EML
Sbjct: 327 WQMIEQIQFIKLFGMAKIDNLLQEML 352
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 216 bits (551), Expect = 3e-56
Identities = 139/406 (34%), Positives = 200/406 (49%), Gaps = 45/406 (11%)
Query: 162 INSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYS 221
++STV+ +G + P G GL P P C +CGD SSGKHYG+Y+
Sbjct: 9 MSSTVAAAAPAAGAASRKESP--GRWGLGEDPTGVSPSLQ---CRVCGDSSSGKHYGIYA 63
Query: 222 CEGCKGFFKRTIRKDLTYSCRDNKD-CTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQ 280
C GC GFFKR++R+ L Y C+ C VDK RN+CQ CR +KCL GM ++AVQ ERQ
Sbjct: 64 CNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ 123
Query: 281 RGKDK----DGDGEGAGGAPEEM-----PVDR---------------------ILEAELA 310
D PE + P R ++ AE
Sbjct: 124 PRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETC 183
Query: 311 VEQKSDQGVEGPGGTGGSGSSPNDPVTN--------ICQAADKQLFTLVEWAKRIPHFSS 362
+ + + E T P+ P ++ I + + + LF V+WAK +P FSS
Sbjct: 184 AKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSS 243
Query: 363 LPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSA-GVGAIFDRVL 421
LP DQVILL W+EL + S+ + LLA A + ++ RVL
Sbjct: 244 LPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVL 303
Query: 422 TELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE 481
E +S+ R + +D TE C++A++LF P+ +GL +P VE L+++ L + K +P
Sbjct: 304 QETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPS 363
Query: 482 QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
Q RF KLLL LP+LR I + +E LFF K IG+TP++ L +M +
Sbjct: 364 QPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFK 409
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 212 bits (540), Expect = 6e-55
Identities = 119/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 100 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 159
Query: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
+ KCL GM +E V+ +R RG + D E + P + P+ +I+ L
Sbjct: 160 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVA 219
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E + PG G + +T +C AD++L ++ WAK IP FSSL L DQ+ L
Sbjct: 220 EPDKLYAMPPPGMPEGDIKA----LTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSL 275
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
L++ W E+LI +RS+ D ++ A + + AG+ ++ R + +LV + + +
Sbjct: 276 LQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELY-RAILQLVRRYKKL 334
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+++K E L+A+ L N D+ + + V+ L++ ++ +L+ Y + E+ R KLLL
Sbjct: 335 KVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLL 394
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 395 TLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEA 431
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 209 bits (533), Expect = 4e-54
Identities = 118/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 102 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 161
Query: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
+ KCL GM +E V+ +R RG + D E + P + P ++I+ L
Sbjct: 162 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVA 221
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E + + P S +T +C AD++L ++ WAK IP FS+L L DQ+ L
Sbjct: 222 EPEKIYAMPDP----TVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL 277
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
L++ W E+LI +RS+ D ++ A + + + AG+ + + +L +LV K + M
Sbjct: 278 LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSM 336
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+++K E L+AI L N D+ + + V+ L++ ++ +L+ Y ++ E R K+L+
Sbjct: 337 KLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLM 396
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 397 TLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 209 bits (533), Expect = 4e-54
Identities = 118/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 102 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 161
Query: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
+ KCL GM +E V+ +R RG + D E + P + P ++I+ L
Sbjct: 162 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVA 221
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E + + P S +T +C AD++L ++ WAK IP FS+L L DQ+ L
Sbjct: 222 EPEKIYAMPDP----TVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL 277
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
L++ W E+LI +RS+ D ++ A + + + AG+ + + +L +LV K + M
Sbjct: 278 LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSM 336
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+++K E L+AI L N D+ + + V+ L++ ++ +L+ Y ++ E R K+L+
Sbjct: 337 KLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLM 396
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 397 TLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 209 bits (533), Expect = 4e-54
Identities = 118/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 125 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 184
Query: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
+ KCL GM +E V+ +R RG + D E + P + P ++I+ L
Sbjct: 185 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVA 244
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E + + P S +T +C AD++L ++ WAK IP FS+L L DQ+ L
Sbjct: 245 EPEKIYAMPDP----TVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL 300
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
L++ W E+LI +RS+ D ++ A + + + AG+ + + +L +LV K + M
Sbjct: 301 LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSM 359
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+++K E L+AI L N D+ + + V+ L++ ++ +L+ Y ++ E R K+L+
Sbjct: 360 KLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLM 419
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 420 TLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEA 456
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 209 bits (533), Expect = 4e-54
Identities = 118/337 (35%), Positives = 185/337 (54%), Gaps = 15/337 (4%)
Query: 202 KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCR 261
KRLC +CGD +SG HYGV SCE CK FFKRTI+ ++ YSC +C + KR+R CQ CR
Sbjct: 102 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 161
Query: 262 YQKCLATGMKREAVQEERQRG----KDKDGDGEGAG------GAPEEMPVDRILEAELAV 311
+ KCL GM +E V+ +R RG + D E + P + P ++I+ L
Sbjct: 162 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVA 221
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
E + + P S +T +C AD++L ++ WAK IP FS+L L DQ+ L
Sbjct: 222 EPEKIYAMPDP----TVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL 277
Query: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
L++ W E+LI +RS+ D ++ A + + + AG+ + + +L +LV K + M
Sbjct: 278 LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSM 336
Query: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
+++K E L+AI L N D+ + + V+ L++ ++ +L+ Y ++ E R K+L+
Sbjct: 337 KLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLM 396
Query: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 528
LP LR K ++H + KL G P+ +EMLEA
Sbjct: 397 TLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 207 bits (526), Expect = 3e-53
Identities = 137/427 (32%), Positives = 211/427 (49%), Gaps = 31/427 (7%)
Query: 111 PSLGGSGAPPPPPMPPPPLGSP-FPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLP 169
P G GA P P GSP F ++S S G P S V + +S +P
Sbjct: 16 PGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVP 75
Query: 170 GGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFF 229
S PP PP P C +C D+SSG HYGV SCEGCKGFF
Sbjct: 76 SSPSPPP---------------PPRVYKP------CFVCNDKSSGYHYGVSSCEGCKGFF 114
Query: 230 KRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDG 289
+R+I+K++ Y+C +K+C ++K RNRCQYCR QKC GM +EAV+ +R + K K+
Sbjct: 115 RRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNK-KKKEVKE 173
Query: 290 EGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQA 342
EG+ + E P ++ ++ Q++ + G + S+ + ++ +
Sbjct: 174 EGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSEL 233
Query: 343 ADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLH 402
A K + +VE+AKR+P F+ L + DQ+ LL+A ++L+ R +D + + GL
Sbjct: 234 ATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLT 293
Query: 403 VHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEV 462
++R H+AG G + D V ++ + MD TE G L AI L D L P +V+
Sbjct: 294 LNRTQMHNAGFGPLTDLVFA-FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDK 352
Query: 463 LREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL 522
L+E + +L Y +++ P Q F ++L+++ LR I K E K+ P+ +
Sbjct: 353 LQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLI 412
Query: 523 MEMLEAP 529
EMLE P
Sbjct: 413 REMLENP 419
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 206 bits (524), Expect = 4e-53
Identities = 127/372 (34%), Positives = 188/372 (50%), Gaps = 53/372 (14%)
Query: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD--CTVDKRQRNRCQYCRY 262
C +CGDRSSGKHYGVY+C+GC GFFKR+IR++ TY C+ C VDK RN+C+ CR
Sbjct: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
Query: 263 QKCLATGMKREAVQEERQ--------------RGKDKDGDGEGAGGAPEEMPVDRILEAE 308
+KCL M ++AVQ ER RG K+ +G A +P A
Sbjct: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGH-KEENGAAAHFPSAALPAPAFFTA- 133
Query: 309 LAVEQKSDQGVE----------------------GPGGTGGSGSSPNDPVT-NICQAADK 345
V Q G+E P G+ + T ++C++A +
Sbjct: 134 --VTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAAR 191
Query: 346 QLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHR 405
LF ++WAK +P FS+L L DQ++LL W EL + + +I V LLA ++
Sbjct: 192 LLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVS-GMNG 250
Query: 406 NSAHSAGVGAIFDRV--LTELVSKMRDMRMDKTELGCLRAIILFNP-------DAKGLSN 456
++ S + I + L E+V++ R +R+D TE CL+ I+ F + + N
Sbjct: 251 DNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRN 310
Query: 457 PSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT 516
+ + L+++ +L +Y +YP Q RF KLLL LPALRSI +E +FF K IG+
Sbjct: 311 AAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNV 370
Query: 517 PIDTFLMEMLEA 528
PI L +M ++
Sbjct: 371 PITRLLSDMYKS 382
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 205 bits (521), Expect = 1e-52
Identities = 127/365 (34%), Positives = 188/365 (51%), Gaps = 36/365 (9%)
Query: 195 PGGPGAGK--------RLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD 246
PG G GK RLC +CGD +SG HYGV SCE CK FFKRTI+ + YSC + +
Sbjct: 61 PGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE 120
Query: 247 CTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKD------------------GD 288
C + KR+R CQ CR+ KCL GM +E V+ +R RG + G
Sbjct: 121 CEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGP 180
Query: 289 GEGAGGAPE-EMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQL 347
AGG + PV+ ++ L VE + + P G G + V +C D+++
Sbjct: 181 LAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPA----VATLCDLFDREI 236
Query: 348 FTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNS 407
+ WAK IP FSSL L DQ+ +L++ W E+L+ + RS+ ++D + A L +
Sbjct: 237 VVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEG 296
Query: 408 AHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKV 467
A +AG+G + L +LV +++ +R+++ E L+A+ L N D+ + + VE LRE +
Sbjct: 297 ARAAGLGEL-GAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREAL 355
Query: 468 YASLETYCKQKYPEQQG----RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM 523
+ +L Y + G R +LLL LP LR K L H + KL G P+ +
Sbjct: 356 HEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFL 415
Query: 524 EMLEA 528
EMLEA
Sbjct: 416 EMLEA 420
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 203 bits (516), Expect = 4e-52
Identities = 132/414 (31%), Positives = 209/414 (50%), Gaps = 27/414 (6%)
Query: 128 PLGSPFPVI-------SSSMGSPGLPPPAPPGFSGPVSSPQIN-STVSLPGGGSGPPEDV 179
P +PF V+ + + GLP P P +S P+ +P N S S+ S E V
Sbjct: 10 PTPNPFLVVDFYNQNRACLLPEKGLPAPGP--YSTPLRTPLWNGSNHSIETQSSSSEEIV 67
Query: 180 KPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTY 239
P P PP P K C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y
Sbjct: 68 PSP---------PSPPPLPRIYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY 117
Query: 240 SCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEM 299
+C +K+C ++K RNRCQYCR QKC GM +E+V+ +R + K + E +
Sbjct: 118 TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTP 177
Query: 300 PVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPN------DPVTNICQAADKQLFTLVEW 353
V ++E Q++ + G + SS D + + K + VE+
Sbjct: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
Query: 354 AKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGV 413
AK++P F++L + DQ+ LL+A ++LI R +D + + GL ++R H+AG
Sbjct: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
Query: 414 GAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLET 473
G + D V +++ + MD E G L AI L D + L P V++L+E + +L+
Sbjct: 298 GPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 356
Query: 474 YCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
Y +++ P + F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 357 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 410
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 202 bits (515), Expect = 5e-52
Identities = 118/345 (34%), Positives = 187/345 (54%), Gaps = 10/345 (2%)
Query: 192 PPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDK 251
P PP P K C +C D+SSG HYGV SCEGCKGFF+R+I+K++ Y+C +K+C ++K
Sbjct: 67 PSPPPPPRVYKP-CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINK 125
Query: 252 RQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELA 310
RNRCQYCR QKC GM +EAV+ +R + K K+ EG+ + E P ++ ++
Sbjct: 126 VTRNRCQYCRLQKCFEVGMSKEAVRNDRNK-KKKEVKEEGSPDSYELSPQLEELITKVSK 184
Query: 311 VEQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQAADKQLFTLVEWAKRIPHFSSLP 364
Q++ + G + S+ + ++ + A K + +VE+AKR+P F+ L
Sbjct: 185 AHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLS 244
Query: 365 LDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTEL 424
+ DQ+ LL+A ++L+ R +D + + GL ++R H+AG G + D V
Sbjct: 245 IADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-F 303
Query: 425 VSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQG 484
++ + MD TE G L AI L D L P +V+ L+E + +L Y +++ P Q
Sbjct: 304 AGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPY 363
Query: 485 RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 529
F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 364 MFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 202 bits (514), Expect = 6e-52
Identities = 114/342 (33%), Positives = 186/342 (54%), Gaps = 7/342 (2%)
Query: 192 PPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDK 251
PP P P + C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y+C +K+C ++K
Sbjct: 68 PPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINK 127
Query: 252 RQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAV 311
RNRCQYCR QKC GM +E+V+ +R + K + E +D + E
Sbjct: 128 VTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKA 187
Query: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQAADKQLFTLVEWAKRIPHFSSLPL 365
Q++ + G + S+ + ++ + A K + +VE+AKR+P F+ L +
Sbjct: 188 HQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTI 247
Query: 366 DDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELV 425
DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D V T
Sbjct: 248 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFT-FA 306
Query: 426 SKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGR 485
+++ + MD TE G L AI L D + L P++V+ L+E + +L+ Y +++ P +
Sbjct: 307 NQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHM 366
Query: 486 FAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 367 FPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 200 bits (508), Expect = 3e-51
Identities = 128/409 (31%), Positives = 201/409 (49%), Gaps = 19/409 (4%)
Query: 125 PPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVL 184
P PP FP + + PG PVS S ++ S E V P
Sbjct: 20 PVPPYAFFFPPMLGGLSPPGALTTLQHQL--PVSGYSTPSPATIETQSSSSEEIVPSP-- 75
Query: 185 GVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDN 244
P PP P K C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y+C +
Sbjct: 76 -------PSPPPLPRIYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRD 127
Query: 245 KDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRI 304
K+C ++K RNRCQYCR QKC GM +E+V+ +R + K + E + V +
Sbjct: 128 KNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGEL 187
Query: 305 LEAELAVEQKSDQGVEGPGGTGGSGSSPN------DPVTNICQAADKQLFTLVEWAKRIP 358
+E Q++ + G + SS D + + K + VE+AK++P
Sbjct: 188 IEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLP 247
Query: 359 HFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFD 418
F++L + DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D
Sbjct: 248 GFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 307
Query: 419 RVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQK 478
V +++ + MD E G L AI L D + L P V++L+E + +L+ Y +++
Sbjct: 308 LVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKR 366
Query: 479 YPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
P + F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 367 RPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 200 bits (508), Expect = 3e-51
Identities = 128/409 (31%), Positives = 201/409 (49%), Gaps = 19/409 (4%)
Query: 125 PPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVL 184
P PP FP + + PG PVS S ++ S E V P
Sbjct: 20 PVPPYAFFFPPMLGGLSPPGALTTLQHQL--PVSGYSTPSPATIETQSSSSEEIVPSP-- 75
Query: 185 GVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDN 244
P PP P K C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y+C +
Sbjct: 76 -------PSPPPLPRIYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRD 127
Query: 245 KDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRI 304
K+C ++K RNRCQYCR QKC GM +E+V+ +R + K + E + V +
Sbjct: 128 KNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGEL 187
Query: 305 LEAELAVEQKSDQGVEGPGGTGGSGSSPN------DPVTNICQAADKQLFTLVEWAKRIP 358
+E Q++ + G + SS D + + K + VE+AK++P
Sbjct: 188 IEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLP 247
Query: 359 HFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFD 418
F++L + DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D
Sbjct: 248 GFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 307
Query: 419 RVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQK 478
V +++ + MD E G L AI L D + L P V++L+E + +L+ Y +++
Sbjct: 308 LVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKR 366
Query: 479 YPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
P + F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 367 RPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 188 bits (478), Expect = 9e-48
Identities = 139/473 (29%), Positives = 211/473 (44%), Gaps = 61/473 (12%)
Query: 96 PPPSPPGPPLPPSTA-------PSLGGSGAPPP---PPMPPPPL--GSPFPVISSSMGSP 143
PP +P P PP PS G AP P PPM P G+ FP+ P
Sbjct: 150 PPSTPTTPAFPPQAGALWDEALPSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPP 209
Query: 144 GLPPPAPPGFSGPVSSPQINSTVSLPGGGSG---------------------------PP 176
P P+P G P + +SLP G + PP
Sbjct: 210 HPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPP 269
Query: 177 EDVKPP-----VLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKR 231
+ P +LG PP +G+ CA+CGD ++ +HYGV +CEGCKGFFKR
Sbjct: 270 LGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKR 329
Query: 232 TIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGK-------- 283
T++K+ Y C NK+C VDKR+RNRCQYCR+QKCL+ GM +E V+ + +G+
Sbjct: 330 TVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKP 389
Query: 284 DKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVE----GPGGTGGSGSSPNDPVTNI 339
E + +P P+ + A+ + + ++ P +G+ + V
Sbjct: 390 KSPLQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDA-EHVQQF 448
Query: 340 CQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLAT 399
+ WA++IP F+ LP +DQ +L+ + + EL + S RS D +
Sbjct: 449 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 508
Query: 400 GLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSE 459
GL +HR G G D + + ++ + +D L CL A+ + + GL P
Sbjct: 509 GLVLHRLQC-LRGFGEWLDSI-KDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKR 565
Query: 460 VEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKL 512
VE L K+ +SL+ + + K + +K+L L LR I L+ +F+ KL
Sbjct: 566 VEELCNKITSSLKDH-QSKGQALEPTESKVLGALVELRKICTLGLQRIFYLKL 617
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 188 bits (478), Expect = 9e-48
Identities = 139/473 (29%), Positives = 211/473 (44%), Gaps = 61/473 (12%)
Query: 96 PPPSPPGPPLPPSTA-------PSLGGSGAPPP---PPMPPPPL--GSPFPVISSSMGSP 143
PP +P P PP PS G AP P PPM P G+ FP+ P
Sbjct: 139 PPSTPTTPAFPPQAGALWDEALPSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPP 198
Query: 144 GLPPPAPPGFSGPVSSPQINSTVSLPGGGSG---------------------------PP 176
P P+P G P + +SLP G + PP
Sbjct: 199 HPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPP 258
Query: 177 EDVKPP-----VLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKR 231
+ P +LG PP +G+ CA+CGD ++ +HYGV +CEGCKGFFKR
Sbjct: 259 LGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKR 318
Query: 232 TIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGK-------- 283
T++K+ Y C NK+C VDKR+RNRCQYCR+QKCL+ GM +E V+ + +G+
Sbjct: 319 TVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKP 378
Query: 284 DKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVE----GPGGTGGSGSSPNDPVTNI 339
E + +P P+ + A+ + + ++ P +G+ + V
Sbjct: 379 KSPLQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDA-EHVQQF 437
Query: 340 CQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLAT 399
+ WA++IP F+ LP +DQ +L+ + + EL + S RS D +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 400 GLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSE 459
GL +HR G G D + + ++ + +D L CL A+ + + GL P
Sbjct: 498 GLVLHRLQC-LRGFGEWLDSI-KDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKR 554
Query: 460 VEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKL 512
VE L K+ +SL+ + + K + +K+L L LR I L+ +F+ KL
Sbjct: 555 VEELCNKITSSLKDH-QSKGQALEPTESKVLGALVELRKICTLGLQRIFYLKL 606
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 188 bits (478), Expect = 9e-48
Identities = 139/473 (29%), Positives = 211/473 (44%), Gaps = 61/473 (12%)
Query: 96 PPPSPPGPPLPPSTA-------PSLGGSGAPPP---PPMPPPPL--GSPFPVISSSMGSP 143
PP +P P PP PS G AP P PPM P G+ FP+ P
Sbjct: 139 PPSTPTTPAFPPQAGALWDEALPSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPP 198
Query: 144 GLPPPAPPGFSGPVSSPQINSTVSLPGGGSG---------------------------PP 176
P P+P G P + +SLP G + PP
Sbjct: 199 HPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPP 258
Query: 177 EDVKPP-----VLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKR 231
+ P +LG PP +G+ CA+CGD ++ +HYGV +CEGCKGFFKR
Sbjct: 259 LGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKR 318
Query: 232 TIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGK-------- 283
T++K+ Y C NK+C VDKR+RNRCQYCR+QKCL+ GM +E V+ + +G+
Sbjct: 319 TVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKP 378
Query: 284 DKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVE----GPGGTGGSGSSPNDPVTNI 339
E + +P P+ + A+ + + ++ P +G+ + V
Sbjct: 379 KSPLQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDA-EHVQQF 437
Query: 340 CQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLAT 399
+ WA++IP F+ LP +DQ +L+ + + EL + S RS D +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 400 GLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSE 459
GL +HR G G D + + ++ + +D L CL A+ + + GL P
Sbjct: 498 GLVLHRLQC-LRGFGEWLDSI-KDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKR 554
Query: 460 VEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKL 512
VE L K+ +SL+ + + K + +K+L L LR I L+ +F+ KL
Sbjct: 555 VEELCNKITSSLKDH-QSKGQALEPTESKVLGALVELRKICTLGLQRIFYLKL 606
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.137 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,228,314
Number of Sequences: 37866
Number of extensions: 2470652
Number of successful extensions: 67948
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1263
Number of HSP's successfully gapped in prelim test: 2122
Number of HSP's that attempted gapping in prelim test: 17040
Number of HSP's gapped (non-prelim): 19701
length of query: 533
length of database: 18,247,518
effective HSP length: 107
effective length of query: 426
effective length of database: 14,195,856
effective search space: 6047434656
effective search space used: 6047434656
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.