Search of human proteins with 21314675

Search of human proteins with 21314675

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21314675 kelch domain containing 4 [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21314675 kelch domain containing 4 [Homo sapiens]                 1084   0.0  
gi|7657301 kelch domain containing 2 [Homo sapiens]                    82   1e-15
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]     77   3e-14
gi|16945972 kelch domain containing 3 [Homo sapiens]                   70   4e-12
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]                70   6e-12
gi|62955044 F-box protein 42 [Homo sapiens]                            65   1e-10
gi|44917619 kelch domain containing 10 [Homo sapiens]                  65   2e-10
gi|98986457 host cell factor 1 [Homo sapiens]                          63   6e-10
gi|7019405 host cell factor C2 [Homo sapiens]                          63   7e-10
gi|26190616 kelch domain containing 1 [Homo sapiens]                   57   4e-08
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ...    52   1e-06
gi|46410931 attractin-like 1 [Homo sapiens]                            45   1e-04
gi|31881798 muskelin 1, intracellular mediator containing kelch ...    40   0.004
gi|223890246 muskelin 1, intracellular mediator containing kelch...    40   0.004
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       39   0.009
gi|122937418 similar to poly(A)binding protein nuclear-like 1 [H...    36   0.075
gi|24475847 influenza virus NS1A binding protein [Homo sapiens]        35   0.13 
gi|21735415 centromere protein B [Homo sapiens]                        35   0.22 
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    35   0.22 
gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Ho...    35   0.22 
gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Ho...    35   0.22 
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                      34   0.37 
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                      34   0.37 
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           33   0.48 
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            33   0.48 
gi|21450863 attractin isoform 2 [Homo sapiens]                         33   0.48 
gi|21450861 attractin isoform 1 [Homo sapiens]                         33   0.48 
gi|23397572 kelch-like 34 [Homo sapiens]                               33   0.48 
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               33   0.63 
gi|42476169 Paf1, RNA polymerase II associated factor, homolog [...    33   0.63 

>gi|21314675 kelch domain containing 4 [Homo sapiens]
          Length = 520

 Score = 1084 bits (2803), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPP 60
           MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPP
Sbjct: 1   MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPP 60

Query: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC 120
           PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC
Sbjct: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC 120

Query: 121 AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGH 180
           AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGH
Sbjct: 121 AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGH 180

Query: 181 RMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTP 240
           RMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTP
Sbjct: 181 RMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTP 240

Query: 241 QGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFS 300
           QGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFS
Sbjct: 241 QGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFS 300

Query: 301 VAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRG 360
           VAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRG
Sbjct: 301 VAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRG 360

Query: 361 RKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLE 420
           RKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLE
Sbjct: 361 RKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLE 420

Query: 421 EAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEM 480
           EAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEM
Sbjct: 421 EAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEM 480

Query: 481 DPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED 520
           DPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED
Sbjct: 481 DPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED 520


>gi|7657301 kelch domain containing 2 [Homo sapiens]
          Length = 406

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 82/333 (24%), Positives = 134/333 (40%), Gaps = 63/333 (18%)

Query: 52  QTVELPCPPP-SPRLNASLSVHPEKDELILFGGEYFNGQKTFLYN------ELYVYNTRK 104
           +++EL CP   S  +  S   H     + ++GG Y + Q   LY+      EL++YN   
Sbjct: 22  ESMELACPAERSGHVAVSDGRH-----MFVWGG-YKSNQVRGLYDFYLPREELWIYNMET 75

Query: 105 DTWTKVDIPSP-PPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATK 163
             W K++     PP      AV V +    L++FGG  +  N  +FY         +   
Sbjct: 76  GRWKKINTEGDVPPSMSGSCAVCVDR---VLYLFGGHHSRGNTNKFYMLDSRSTDRVLQ- 131

Query: 164 TWEQVKSTG-GPSGRSGHRMVAWKRQLILFGGFHESTRDYIY------------------ 204
            WE++   G  PS +    +  +K +LI FGG+     D +                   
Sbjct: 132 -WERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRG 190

Query: 205 YND-VYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGT 263
           +ND V+  + +TFTWS+   +G  P+PR+    +     G V  G Y          +  
Sbjct: 191 WNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY----------RDA 240

Query: 264 RHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEES 323
           R +D+  L       D W W  + P G+ P  RS  S+    +     FGG   +++   
Sbjct: 241 RMNDLHYL-----NLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQP-- 293

Query: 324 LSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKK 356
                 +D + Y  ++N W   Q   P +EK +
Sbjct: 294 -----LSDAWTYCISKNEWI--QFNHPYTEKPR 319


>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
          Length = 372

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 66/210 (31%), Positives = 94/210 (44%), Gaps = 21/210 (10%)

Query: 45  TLDAKRTQTVELPCPPPSPRL-NASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTR 103
           T+D  + Q     C    PR  +AS       D + +FGG   +G +    N L V N  
Sbjct: 67  TMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNR----NCLQVLNPE 122

Query: 104 KDTWTKVDIPSPPPR-RCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLAT 162
             TWT  ++ SPPP  R  H +      G QL+VFGG      G Q      L V    T
Sbjct: 123 TRTWTTPEVTSPPPSPRTFHTSSAAI--GNQLYVFGG---GERGAQPVQDTKLHVFDANT 177

Query: 163 KTWEQVKSTGGP-SGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKL 221
            TW Q ++ G P S R GH MVA   +L + GG         +Y+D++  ++    W KL
Sbjct: 178 LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDR----FYDDLHCIDISDMKWQKL 233

Query: 222 SPSGTGPTPRSGC--QMSVTPQGGIVVYGG 249
           +P+G  P   +GC    +V     + ++GG
Sbjct: 234 NPTGAAP---AGCAAHSAVAMGKHVYIFGG 260



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 68/270 (25%), Positives = 114/270 (42%), Gaps = 35/270 (12%)

Query: 53  TVELPCPPPSPRLNASLSVHP-----EKDELILFGGEYFNGQKTFLYNELYVYNTRKDTW 107
           T+ +P   P  R+  S S  P     ++ ++ + GG   N  ++F  ++++  +  K  W
Sbjct: 20  TLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGA--NPNRSF--SDVHTMDLGKHQW 75

Query: 108 TKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQ 167
                    PR   H + +      ++WVFGG   S N         L VL+  T+TW  
Sbjct: 76  DLDTCKGLLPRY-EHASFIPSCTPDRIWVFGGANQSGNRNC------LQVLNPETRTWTT 128

Query: 168 VKSTGGP-SGRSGHRM-VAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSG 225
            + T  P S R+ H    A   QL +FGG     +  +    ++ F+ +T TWS+    G
Sbjct: 129 PEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQP-VQDTKLHVFDANTLTWSQPETLG 187

Query: 226 TGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTR 285
             P+PR G  M V     + ++GG +  R          + D+  +   D +     W +
Sbjct: 188 NPPSPRHGHVM-VAAGTKLFIHGGLAGDRF---------YDDLHCIDISDMK-----WQK 232

Query: 286 MNPSGVKPTPRSGFSVAMAPNHQTLFFGGV 315
           +NP+G  P   +  S A+A       FGG+
Sbjct: 233 LNPTGAAPAGCAAHS-AVAMGKHVYIFGGM 261


>gi|16945972 kelch domain containing 3 [Homo sapiens]
          Length = 382

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 13/179 (7%)

Query: 78  LILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPR-RCAHQAVVVPQGGGQLWV 136
           + +FGG  +  Q     N+++  +T   TWT +     P R R  H A ++   G  ++V
Sbjct: 140 MYIFGG--YEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATML---GSHMYV 194

Query: 137 FGGE---FASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG-PSGRSGHRMVAWKRQLILF 192
           FGG    F   +     +   + V    T+ W     T   P GR  H    +  +L +F
Sbjct: 195 FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIF 254

Query: 193 GGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYS 251
           GG++   R   +++D++ FN  +FTW K+ P G GP PR   Q        IV++GG S
Sbjct: 255 GGYN--ARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRR-QCCCIVGDKIVLFGGTS 310



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 66/275 (24%), Positives = 104/275 (37%), Gaps = 42/275 (15%)

Query: 76  DELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPP-RRCAHQAVVVPQGGGQL 134
           D ++L+GG           N LY ++     W    +    P  R  H A V+   G  +
Sbjct: 87  DTVLLWGGR---NDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL---GKIM 140

Query: 135 WVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSG-RSGHRMVAWKRQLILFG 193
           ++FGG       + F +  D+  L  +T TW  + + G P+  R  H        + +FG
Sbjct: 141 YIFGGY--EQQADCFSN--DIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFG 196

Query: 194 G-------FHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVV 246
           G       FH +    IY N +  F+  T  W    P+   P  R     +    G + +
Sbjct: 197 GRADRFGPFHSNNE--IYCNRIRVFDTRTEAWLDCPPTPVLPEGRRS-HSAFGYNGELYI 253

Query: 247 YGGYSKQRVKKDVDKGTRH-SDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAP 305
           +GGY+ +          RH  D++   P       + W ++ P G  P PR      +  
Sbjct: 254 FGGYNARL--------NRHFHDLWKFNPVS-----FTWKKIEPKGKGPCPRRRQCCCIVG 300

Query: 306 NHQTLFFGGVCDEEEEESLSGEF----FNDLYFYD 336
           +   LF  G      EE L  EF     +DL+  D
Sbjct: 301 DKIVLF--GGTSPSPEEGLGDEFDLIDHSDLHILD 333



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 58/239 (24%), Positives = 92/239 (38%), Gaps = 33/239 (13%)

Query: 117 PRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG--- 173
           PRR  H AV V   G +++ FGG + S    +     D+ + +  +  W ++        
Sbjct: 12  PRRVNHAAVAV---GHRVYSFGG-YCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIR 67

Query: 174 ------PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTG 227
                 P  R GH  V     ++L+GG +++       N +YAF+++T  W     SGT 
Sbjct: 68  GQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGAC---NVLYAFDVNTHKWFTPRVSGTV 124

Query: 228 PTPRSGCQMSVTPQGGIV-VYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRM 286
           P  R G    V   G I+ ++GGY +Q            +D F             WT +
Sbjct: 125 PGARDGHSACVL--GKIMYIFGGYEQQ------------ADCFSNDIHKLDTSTMTWTLI 170

Query: 287 NPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFF-NDLYFYDATRNRWFE 344
              G     R   S  M  +H  + FGG  D       + E + N +  +D     W +
Sbjct: 171 CTKGSPARWRDFHSATMLGSHMYV-FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLD 228


>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
          Length = 2778

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 89/371 (23%), Positives = 147/371 (39%), Gaps = 69/371 (18%)

Query: 59  PPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPR 118
           P  S R+ A+ +       L +FGG+  N        +L +YN   +TW   D+   P  
Sbjct: 223 PAFSARIGAAGAFLSPPGLLAVFGGQDLNNA----LGDLVLYNFSANTWESWDLSPAPAA 278

Query: 119 RCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLH-LATKTWE----QVKSTGG 173
           R +H AV      G L + GGE A  +        D+W    L    WE       S+ G
Sbjct: 279 RHSHVAVA---WAGSLVLMGGELADGS-----LTNDVWAFSPLGRGHWELLAPPASSSSG 330

Query: 174 PSGRSGHRMV----AWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFT---WSKLSPSGT 226
           P G +GH        W   L + GG    T   ++ + ++ F LD+ +   W ++ P+G 
Sbjct: 331 PPGLAGHAAALVDDVW---LYVSGG---RTPHDLFSSGLFRFRLDSTSGGYWEQVIPAGG 384

Query: 227 GPTPRSGCQMSV-TPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTR 285
            P   +G  M    P   ++V+GG+     +  V      +++F         D+ VWT 
Sbjct: 385 RPPAATGHSMVFHAPSRALLVHGGHRPSTARFSV--RVNSTELF-------HVDRHVWTT 435

Query: 286 M-NPSGVK-PTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWF 343
           +    G++ P  R+  + ++  N+  ++ G V    +EE     + + ++FY    ++W 
Sbjct: 436 LKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKC---YEDGIFFYHLGCHQWV 492

Query: 344 EGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLT 403
            G    P              PEG + P  G             V A  G  V    +L 
Sbjct: 493 SGAELAPPG-----------TPEGRAAPPSG---------RYSHVAAVLGGSV----LLV 528

Query: 404 APGSAGQPRSE 414
           A G +G+PR +
Sbjct: 529 AGGYSGRPRGD 539



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 54/183 (29%), Positives = 78/183 (42%), Gaps = 23/183 (12%)

Query: 78   LILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDI------PSPPPRRCAHQAVVVPQGG 131
            L +FGG    G    L   LY Y+  +  WT++        P P PR   H A  VP G 
Sbjct: 1456 LWMFGGL---GLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSF-HAAAYVPAGR 1511

Query: 132  GQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKS--TGGPSGRSGHRMVAWK-RQ 188
            G +++ GG  A          +D WVL+L T  W Q K+  T      +GH + A +   
Sbjct: 1512 GAMYLLGGLTAGGVT------RDFWVLNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLS 1565

Query: 189  LILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSG-CQMSVTPQGGIVVY 247
            L+L GG+        +   +  + L T TW   + SGT PT   G   +       + V+
Sbjct: 1566 LLLVGGYSPENG---FNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVF 1622

Query: 248  GGY 250
            GG+
Sbjct: 1623 GGF 1625


>gi|62955044 F-box protein 42 [Homo sapiens]
          Length = 717

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 31/210 (14%)

Query: 114 SPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG 173
           +P  +R +H A         ++VFGG   S     F    DLW L L +K W +  ++G 
Sbjct: 114 TPITQRFSHSACYY-DANQSMYVFGGCTQSSCNAAF---NDLWRLDLNSKEWIRPLASGS 169

Query: 174 -PSGRSGHRMVAWKRQLILFGGF--------HESTRDYIYYNDVYAFNLDTFTWSKLSPS 224
            PS ++G  +V +K  L+LFGG+        H+  R   ++++++ ++     W+ +  +
Sbjct: 170 YPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPER---FFDEIHTYSPSKNWWNCIVTT 226

Query: 225 GTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWT 284
             GP P +G    V     IV  G    +++  DV         ++L  E     +W W+
Sbjct: 227 H-GPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDV---------WVLDLE-----QWAWS 271

Query: 285 RMNPSGVKPTPRSGFSVAMAPNHQTLFFGG 314
           + N SG  P PR G S  +  +   L  GG
Sbjct: 272 KPNISGPSPHPRGGQSQIVIDDATILILGG 301



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 47/203 (23%), Positives = 82/203 (40%), Gaps = 11/203 (5%)

Query: 51  TQTVELPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKV 110
           ++T   P  P + R + S   +     + +FGG          +N+L+  +     W + 
Sbjct: 106 SRTYPYPGTPITQRFSHSACYYDANQSMYVFGG-CTQSSCNAAFNDLWRLDLNSKEWIRP 164

Query: 111 DIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYH----YKDLWVLHLATKTWE 166
                 P   A   +VV +    L V  G +  P+    +     + ++     +   W 
Sbjct: 165 LASGSYPSPKAGATLVVYK---DLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWN 221

Query: 167 QVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGT 226
            + +T GP   +GH       ++I+FGG   S +     NDV+  +L+ + WSK + SG 
Sbjct: 222 CIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQ---MSNDVWVLDLEQWAWSKPNISGP 278

Query: 227 GPTPRSGCQMSVTPQGGIVVYGG 249
            P PR G    V     I++ GG
Sbjct: 279 SPHPRGGQSQIVIDDATILILGG 301



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 13/92 (14%)

Query: 76  DELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDI--PSPPPRRCAHQAVVVPQGGGQ 133
           D++I+FGG   + Q +   N+++V +  +  W+K +I  PSP PR    Q V+       
Sbjct: 242 DKMIVFGGSLGSRQMS---NDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVI---DDAT 295

Query: 134 LWVFGGEFASPNGEQFYHYKDLWVLHLATKTW 165
           + + GG    PN      +KD W+LH+ +  W
Sbjct: 296 ILILGG-CGGPNAL----FKDAWLLHMHSGPW 322


>gi|44917619 kelch domain containing 10 [Homo sapiens]
          Length = 442

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 63/242 (26%), Positives = 101/242 (41%), Gaps = 40/242 (16%)

Query: 115 PPPRRCAHQAVVVPQGGGQLWVFGG------EFASPNGEQFYHYKDLWVLHLATKTWEQV 168
           PPP R  H+ V        L+VFGG      E   P+ E +  +++LW  H AT  W Q+
Sbjct: 88  PPPARSGHRCVA---DNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQM 144

Query: 169 KSTG-GPSGRSGHRMVAWKRQLILFGG----FHESTRDYIYYNDVYAFNLDTFTWSKLSP 223
            + G  P   +   +V     L++FGG    F ES       NDV+  N+    W+ LS 
Sbjct: 145 GTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNG-----NDVHVCNVKYKRWALLSC 199

Query: 224 SGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVW 283
            G  P+   G  M++   G + V+GG +      D+ K   ++          RE    W
Sbjct: 200 RGKKPSRIYGQAMAII-NGSLYVFGGTTGYIYSTDLHKLDLNT----------RE----W 244

Query: 284 TRMNPSGVK-PTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
           T++ P+ +    P   +   +A + Q ++  G        S +    N ++ Y+   N W
Sbjct: 245 TQLKPNNLSCDLPEERYRHEIAHDGQRIYILG-----GGTSWTAYSLNKIHAYNLETNAW 299

Query: 343 FE 344
            E
Sbjct: 300 EE 301



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 41/133 (30%), Positives = 62/133 (46%), Gaps = 10/133 (7%)

Query: 93  LYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHY 152
           L+ EL+ Y+     W ++      PR  A  ++V+   G  L VFGG    P GE   + 
Sbjct: 127 LFRELWRYHFATGVWHQMGTDGYMPRELASMSLVL--HGNNLLVFGGT-GIPFGES--NG 181

Query: 153 KDLWVLHLATKTWEQVKSTG-GPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAF 211
            D+ V ++  K W  +   G  PS   G  M      L +FGG    T  YIY  D++  
Sbjct: 182 NDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGG----TTGYIYSTDLHKL 237

Query: 212 NLDTFTWSKLSPS 224
           +L+T  W++L P+
Sbjct: 238 DLNTREWTQLKPN 250



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 24/182 (13%)

Query: 79  ILFGGEY-FNGQKTFLYN-ELYVYNTRKDTWTKVDIPSP----PPRRCAHQAVVVPQGGG 132
           I+ G  Y F G   ++Y+ +L+  +     WT++   +     P  R  H+   +   G 
Sbjct: 214 IINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHE---IAHDGQ 270

Query: 133 QLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQV-----KSTGGPSGRSGHRMVAWKR 187
           ++++ GG          Y    +   +L T  WE++     +  G P+ R  H  V  K 
Sbjct: 271 RIYILGGG----TSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKN 326

Query: 188 QLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVY 247
            + + GG++      +   D++  NL TF W KL    T P P      +VTP G + ++
Sbjct: 327 DVFICGGYNGE----VILGDIWKLNLQTFQWVKL--PATMPEPVYFHCAAVTPAGCMYIH 380

Query: 248 GG 249
           GG
Sbjct: 381 GG 382


>gi|98986457 host cell factor 1 [Homo sapiens]
          Length = 2035

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 73/274 (26%), Positives = 102/274 (37%), Gaps = 46/274 (16%)

Query: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC 120
           P PR          K+ +++FGG         + +EL+VYNT  + W    +    P  C
Sbjct: 28  PVPRPRHGHRAVAIKELIVVFGGG-----NEGIVDELHVYNTATNQWFIPAVRGDIPPGC 82

Query: 121 AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSG---- 176
           A    V    G +L VFGG       E   +  DL+ L  +   W+++K+    +G    
Sbjct: 83  AAYGFVCD--GTRLLVFGGMV-----EYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPC 135

Query: 177 -RSGHRMVAWKRQLILFGGFHESTRDYI-----YYNDVYAFNL----DTFTWSKLSPSGT 226
            R GH       +  LFGG    + D       Y ND+Y   L        W      G 
Sbjct: 136 PRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGV 195

Query: 227 GPTPRSGCQMSV-----TPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKW 281
            P PR      V       +  +V+YGG S          G R  D++ L       D  
Sbjct: 196 LPPPRESHTAVVYTEKDNKKSKLVIYGGMS----------GCRLGDLWTLDI-----DTL 240

Query: 282 VWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGV 315
            W + + SGV P PRS  S     N   +F G V
Sbjct: 241 TWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWV 274



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 27/179 (15%)

Query: 165 WEQVKSTGGP--SGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLS 222
           W++V    GP    R GHR VA K  +++FGG +E   D     +++ +N  T  W    
Sbjct: 19  WKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVD-----ELHVYNTATNQW--FI 71

Query: 223 PSGTGPTPRSGCQMSVTPQGG-IVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKW 281
           P+  G  P           G  ++V+GG         V+ G   +D++ L+       +W
Sbjct: 72  PAVRGDIPPGCAAYGFVCDGTRLLVFGGM--------VEYGKYSNDLYELQAS-----RW 118

Query: 282 VWTRMNP----SGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYD 336
            W R+      +G  P PR G S ++  N   LF G   D E+ ++    + NDLY  +
Sbjct: 119 EWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILE 177



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 57/191 (29%), Positives = 80/191 (41%), Gaps = 41/191 (21%)

Query: 59  PPPSPRLNASLSVHPEKDELILFGG------EYFNGQKTFLYNELYVYNTRKDTWTKV-D 111
           PPP PRL  S S+   K    LFGG      +  N    +L N+LY+   R  +     D
Sbjct: 132 PPPCPRLGHSFSLVGNK--CYLFGGLANDSEDPKNNIPRYL-NDLYILELRPGSGVVAWD 188

Query: 112 IP-----SPPPRRCAHQAVVVPQGG---GQLWVFGGEFASPNGEQFYHYKDLWVLHLATK 163
           IP      PPPR  +H AVV  +      +L ++GG      G       DLW L + T 
Sbjct: 189 IPITYGVLPPPRE-SHTAVVYTEKDNKKSKLVIYGGMSGCRLG-------DLWTLDIDTL 240

Query: 164 TWEQVKSTG-GPSGRSGHRMVAWKRQLILFGGF------------HESTRDYIYYNDVYA 210
           TW +   +G  P  RS H       ++ +FGG+            HE  +++   N +  
Sbjct: 241 TWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHE--KEWKCTNTLAC 298

Query: 211 FNLDTFTWSKL 221
            NLDT  W  +
Sbjct: 299 LNLDTMAWETI 309


>gi|7019405 host cell factor C2 [Homo sapiens]
          Length = 792

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 27/176 (15%)

Query: 165 WEQVKSTGGP--SGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLS 222
           W +V S  GP    R GHR VA +  +I+FGG +E   D     +++ +N  T  W   +
Sbjct: 9   WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIAD-----ELHVYNTATNQWFLPA 63

Query: 223 PSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWV 282
             G  P P       V     I+V+GG         V+ G   ++++ L+       +W+
Sbjct: 64  VRGDIP-PGCAAHGFVCDGTRILVFGGM--------VEYGRYSNELYELQAS-----RWL 109

Query: 283 WTRMNP----SGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLS-GEFFNDLY 333
           W ++ P    SG+ P PR G S ++  N +   FGG+ +E E+ + +   + ND Y
Sbjct: 110 WKKVKPHPPPSGLPPCPRLGHSFSLYGN-KCYLFGGLANESEDSNNNVPRYLNDFY 164



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/286 (25%), Positives = 109/286 (38%), Gaps = 50/286 (17%)

Query: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC 120
           P PR          ++ +I+FGG         + +EL+VYNT  + W    +    P  C
Sbjct: 18  PVPRARHGHRAVAIRELMIIFGGG-----NEGIADELHVYNTATNQWFLPAVRGDIPPGC 72

Query: 121 AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSG---- 176
           A    V    G ++ VFGG       E   +  +L+ L  +   W++VK    PSG    
Sbjct: 73  AAHGFVC--DGTRILVFGGMV-----EYGRYSNELYELQASRWLWKKVKPHPPPSGLPPC 125

Query: 177 -RSGHRMVAWKRQLILFGGFHESTRDY-----IYYNDVYAFNLD----TFTWSKLSPSGT 226
            R GH    +  +  LFGG    + D       Y ND Y   L        WS     G 
Sbjct: 126 PRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGV 185

Query: 227 GPTPRSG------CQM-SVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGRED 279
            P+PR        C+  S +P+  + V+GG            G R  D++ L  E     
Sbjct: 186 VPSPRESHTAVIYCKKDSGSPK--MYVFGGMC----------GARLDDLWQLDLE----- 228

Query: 280 KWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLS 325
              W++    G  P PRS  + ++  N   +F G V  + E    S
Sbjct: 229 TMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETS 274



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 68/265 (25%), Positives = 104/265 (39%), Gaps = 44/265 (16%)

Query: 78  LILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRR---CAHQAVVVPQGGGQL 134
           +++FGG    G+ +   NELY     +  W KV  P PPP     C          G + 
Sbjct: 84  ILVFGGMVEYGRYS---NELYELQASRWLWKKVK-PHPPPSGLPPCPRLGHSFSLYGNKC 139

Query: 135 WVFGG---EFASPNGEQFYHYKDLWVLHLATKT----WEQVKSTGG-PSGRSGHRMVAWK 186
           ++FGG   E    N     +  D + L L   +    W    + G  PS R  H  V + 
Sbjct: 140 YLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYC 199

Query: 187 RQ------LILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTP 240
           ++      + +FGG   +  D     D++  +L+T +WSK    GT P PRS    SV  
Sbjct: 200 KKDSGSPKMYVFGGMCGARLD-----DLWQLDLETMSWSKPETKGTVPLPRSLHTASVIG 254

Query: 241 Q-----GGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRM------NPS 289
                 GG V + G + +    D +     S  +L        D   WT +      +  
Sbjct: 255 NKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYL------NLDTTEWTTLVSDSQEDKK 308

Query: 290 GVKPTPRSGFSVAMAPNHQTLFFGG 314
             +P PR+G   A+A   +  F+ G
Sbjct: 309 NSRPRPRAG-HCAVAIGTRLYFWSG 332


>gi|26190616 kelch domain containing 1 [Homo sapiens]
          Length = 406

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 46/190 (24%), Positives = 82/190 (43%), Gaps = 29/190 (15%)

Query: 177 RSGHRMVAWKRQLILFGGFH--ESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGC 234
           RSGH  V     L ++GG+   E    Y+  ++++ +++D+  W      G  P   SG 
Sbjct: 13  RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSG- 71

Query: 235 QMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNP-SGVKP 293
                  G + ++GGY         DKG  +S+         R++ ++W ++    G  P
Sbjct: 72  SCGACINGKLYIFGGYD--------DKG--YSNRLYFVNLRTRDETYIWEKITDFEGQPP 121

Query: 294 TPRSGFSVAMAPNHQTLFFGG--------------VCDEEEEESLSGEFFNDLYFYDATR 339
           TPR   S  +  + + ++FGG              V D   EE +   + ND++ +D   
Sbjct: 122 TPRDKLSCWVYKD-RLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKT 180

Query: 340 NRWFEGQLKG 349
             WF+ ++KG
Sbjct: 181 QTWFQPEIKG 190



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 60/243 (24%), Positives = 97/243 (39%), Gaps = 40/243 (16%)

Query: 119 RCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG-PSGR 177
           R  H AVV    G  L+V+GG  +  + E +    ++W   + +  W      G  P+  
Sbjct: 13  RSGHCAVV---DGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASM 69

Query: 178 SGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNL----DTFTWSKLSP-SGTGPTPRS 232
           SG        +L +FGG+     D  Y N +Y  NL    +T+ W K++   G  PTPR 
Sbjct: 70  SGSCGACINGKLYIFGGYD----DKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRD 125

Query: 233 GCQMSVTPQGGIVVYGGYSKQRVKK-----DVDKGT--------RHSDMFLLKPEDGRED 279
                V  +  ++ +GGY  +R  +     DV   +         H+D+ +    D +  
Sbjct: 126 KLSCWVY-KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIF---DTKTQ 181

Query: 280 KWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATR 339
            W    +   GV P PR+  + A+  N   +F G V              NDL++ +   
Sbjct: 182 TWFQPEIK-GGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR---------MNDLHYLNLDT 231

Query: 340 NRW 342
             W
Sbjct: 232 WTW 234



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 83/210 (39%), Gaps = 48/210 (22%)

Query: 77  ELILFGGEYFNGQKTFLYNELYVYN--TRKDT--WTKV-DIPSPPPRRCAHQAVVVPQGG 131
           +L +FGG    G      N LY  N  TR +T  W K+ D    PP          P+  
Sbjct: 80  KLYIFGGYDDKGYS----NRLYFVNLRTRDETYIWEKITDFEGQPP---------TPRDK 126

Query: 132 GQLWV-------FGGEFASPNGE--------------QFYH--YKDLWVLHLATKTWEQV 168
              WV       FGG     + E              Q +   + D+ +    T+TW Q 
Sbjct: 127 LSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQP 186

Query: 169 KSTGG--PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWS-KLSPSG 225
           +  GG  P  R+ H       +  +FGG    TR     ND++  NLDT+TWS +++ +G
Sbjct: 187 EIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR----MNDLHYLNLDTWTWSGRITING 242

Query: 226 TGPTPRSGCQMSVTPQGGIVVYGGYSKQRV 255
             P  RS   ++      + + GG S   +
Sbjct: 243 ESPKHRSWHTLTPIADDKLFLCGGLSADNI 272



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 55/237 (23%), Positives = 94/237 (39%), Gaps = 54/237 (22%)

Query: 132 GQLWVFGGEFASPNGEQFYHYKDLWVLHLATKT----WEQVKSTGGPSGRSGHRMVAW-- 185
           G+L++FGG       +   +   L+ ++L T+     WE++    G       ++  W  
Sbjct: 79  GKLYIFGGY------DDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132

Query: 186 KRQLILFGGF----HESTRDYI--------------YYNDVYAFNLDTFTWSKLS-PSGT 226
           K +LI FGG+    H   +D                ++NDV+ F+  T TW +     G 
Sbjct: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGV 192

Query: 227 GPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWT-R 285
            P PR+    +V    G  ++GG   Q         TR +D+  L       D W W+ R
Sbjct: 193 PPQPRAAHTCAVLGNKG-YIFGGRVLQ---------TRMNDLHYL-----NLDTWTWSGR 237

Query: 286 MNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
           +  +G  P  RS  ++    + +    GG+       S      +D + ++ T N W
Sbjct: 238 ITINGESPKHRSWHTLTPIADDKLFLCGGL-------SADNIPLSDGWIHNVTTNCW 287


>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
           sapiens]
          Length = 840

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 62/267 (23%), Positives = 97/267 (36%), Gaps = 72/267 (26%)

Query: 60  PPSPRLNASLSVHPEKDELILFGG---EYFNGQKTFLYNELYVYNTRKDTWTKVDIPSP- 115
           PP+PR + S  V+     + +FGG   + ++       N+L+ Y      WT+  I    
Sbjct: 114 PPAPRYHHSAVVYGSS--MFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRL 171

Query: 116 PPRRCAHQAVVVPQGGGQLWVFGG-----------------------EFASPNGE----- 147
           P  R AH A V      +LW+F G                       E  + +GE     
Sbjct: 172 PVARSAHGATVYSD---KLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSC 228

Query: 148 ----------QFYHYK---------DLWVLHLATKTWEQVK-------STGGPSGRSGHR 181
                     + + +          +L+      KTW ++        S   P  R GH 
Sbjct: 229 CNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHT 288

Query: 182 MVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPS-----GTGPTPRSGCQM 236
           MVA+ R L +FGG  ++T      N+++ +++D  TW  + PS     G    P   C  
Sbjct: 289 MVAFDRHLYVFGGAADNTLP----NELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACAS 344

Query: 237 SVTPQGGIVVYGGYSKQRVKKDVDKGT 263
              P        G+ K R    +D GT
Sbjct: 345 EEVPTLTYEERVGFKKSRDVFGLDFGT 371



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 12/137 (8%)

Query: 177 RSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQM 236
           RS H +VA+K  + +FGG +  T      ND+  F++   +W +   +GT P PR     
Sbjct: 68  RSKHTVVAYKDAIYVFGGDNGKTM----LNDLLRFDVKDCSWCRAFTTGTPPAPRYH-HS 122

Query: 237 SVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPR 296
           +V     + V+GGY+         K    +D+F  K   G+     WT     G  P  R
Sbjct: 123 AVVYGSSMFVFGGYTGDIYSNSNLK--NKNDLFEYKFATGQ-----WTEWKIEGRLPVAR 175

Query: 297 SGFSVAMAPNHQTLFFG 313
           S     +  +   +F G
Sbjct: 176 SAHGATVYSDKLWIFAG 192



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 32/133 (24%), Positives = 49/133 (36%), Gaps = 18/133 (13%)

Query: 218 WSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKG-TRHSDMFLLKPEDG 276
           W +L P       R      V  +  I V+GG          D G T  +D+     +D 
Sbjct: 54  WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG----------DNGKTMLNDLLRFDVKDC 103

Query: 277 REDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYD 336
                 W R   +G  P PR   S  +  +   +F G   D     +L  +  NDL+ Y 
Sbjct: 104 S-----WCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNK--NDLFEYK 156

Query: 337 ATRNRWFEGQLKG 349
               +W E +++G
Sbjct: 157 FATGQWTEWKIEG 169


>gi|46410931 attractin-like 1 [Homo sapiens]
          Length = 1379

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 11/115 (9%)

Query: 114 SPPPRRCAHQAVVVPQGGGQLWVFGG-EFASPNGEQFYHYKDLWVLHLATKTWEQVKSTG 172
           SP   R +H+AV+    G  +WV GG  F   + +   +Y      +L +  W     + 
Sbjct: 300 SPSVGRASHKAVL---HGKFMWVIGGYTFNYSSFQMVLNY------NLESSIWNVGTPSR 350

Query: 173 GPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTG 227
           GP  R GH +  ++  + ++GG  E T D    ++++ FN+ + +WS  +P+  G
Sbjct: 351 GPLQRYGHSLALYQENIFMYGGRIE-TNDGNVTDELWVFNIHSQSWSTKTPTVLG 404



 Score = 36.2 bits (82), Expect = 0.075
 Identities = 38/150 (25%), Positives = 59/150 (39%), Gaps = 19/150 (12%)

Query: 70  SVHPEKDELILFGGEY--FNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVV 127
           SV+ E  + I   G Y    G K  L ++LY Y     TWT   +      R  H AV++
Sbjct: 472 SVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWT--ILKESGFARYLHSAVLI 529

Query: 128 PQGGGQLWVFGG----EFASPNGEQFYHYKDLWVLHLATKTWEQVKSTG--GPSGRSGHR 181
               G + +FGG    + +  NG + +   D     +A   W+ +          R GH 
Sbjct: 530 ---NGAMLIFGGNTHNDTSLSNGAKCFS-ADFLAYDIACDEWKILPKPNLHRDVNRFGHS 585

Query: 182 MVAWKRQLILFGGFHESTRDYIYYNDVYAF 211
            V     + +FGGF       +  ND+  +
Sbjct: 586 AVVINGSMYIFGGFSS-----VLLNDILVY 610



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 2/59 (3%)

Query: 416 EDSLEEAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAW 474
           E S+   G+P+ GP  R    LA+    +++YGG  E  D  VT  +L   ++H  ++W
Sbjct: 339 ESSIWNVGTPSRGPLQRYGHSLALYQENIFMYGGRIETNDGNVT-DELWVFNIH-SQSW 395



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 47/214 (21%), Positives = 85/214 (39%), Gaps = 38/214 (17%)

Query: 54  VELPCPPPSPRLNASLSVHPEKDELILFGG--EYFNGQKTFLYNELYVYNTRKDTWTKVD 111
           V  P   P  R   SL+++ E   + ++GG  E  +G  T   +EL+V+N    +W+   
Sbjct: 345 VGTPSRGPLQRYGHSLALYQEN--IFMYGGRIETNDGNVT---DELWVFNIHSQSWS--- 396

Query: 112 IPSPPPRRCAHQAVVVPQGGG------------QLWVFGGEFASPNGEQFYHYKDLWVLH 159
             +  P    H      +G               + +FG             Y      H
Sbjct: 397 --TKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEY------H 448

Query: 160 LATKTWEQVKSTGG-PSGRSGHRMVAWK--RQLILFGGFHESTRD-YIYYNDVYAFNLDT 215
           +++ TW   ++ G    G  GH  V  +  + + + GG+     + Y   +D+Y + ++T
Sbjct: 449 ISSNTWLVPETKGAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNT 508

Query: 216 FTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGG 249
            TW+ L  SG      S    +V   G ++++GG
Sbjct: 509 KTWTILKESGFARYLHS----AVLINGAMLIFGG 538



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 8/123 (6%)

Query: 134 LWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFG 193
           ++V GG  A P G ++    DL+   + TKTW  +K +G    R  H  V     +++FG
Sbjct: 481 IYVHGGYKALP-GNKYGLVDDLYKYEVNTKTWTILKESG--FARYLHSAVLINGAMLIFG 537

Query: 194 G-FHESTR----DYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYG 248
           G  H  T        +  D  A+++    W  L               +V   G + ++G
Sbjct: 538 GNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVNRFGHSAVVINGSMYIFG 597

Query: 249 GYS 251
           G+S
Sbjct: 598 GFS 600


>gi|31881798 muskelin 1, intracellular mediator containing kelch
           motifs isoform 2 [Homo sapiens]
          Length = 735

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 62/311 (19%), Positives = 111/311 (35%), Gaps = 49/311 (15%)

Query: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPS-----P 115
           P  R    + +  + + + LFGG  ++G +     + + Y+ +++ WT +   +     P
Sbjct: 268 PGMRGGHQMVIDVQTETVYLFGG--WDGTQDLA--DFWAYSVKENQWTCISRDTEKENGP 323

Query: 116 PPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTW----EQVKST 171
             R C    + + +   Q++  G    S          D +   + T TW    E   + 
Sbjct: 324 SARSCHKMCIDIQRR--QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAAD 381

Query: 172 GGPSGRSGHRMV--AWKRQLILFGG--------FHESTRDYIYYNDVYAFNLDTFTWSKL 221
           GGP     H+M   + K  +  FGG          +S      ++ ++AFN    TW  L
Sbjct: 382 GGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLL 441

Query: 222 SPSGTGPTPRS------GCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPED 275
                   P         C +  +    + V+GG   +    D       SD   +  + 
Sbjct: 442 REDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDG 501

Query: 276 GREDKWVWTRMNPSGVKPTPRSGFS----VAMAPNHQTLFFGGVCDEEEEESLSGEFFND 331
            ++D         SG+   P +GF+    +    N   +  G   D+E+ E       N 
Sbjct: 502 TKKD---------SGM--VPMTGFTQRATIDPELNEIHVLSGLSKDKEKREE---NVRNS 547

Query: 332 LYFYDATRNRW 342
            + YD  RN W
Sbjct: 548 FWIYDIVRNSW 558



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 39/147 (26%), Positives = 61/147 (41%), Gaps = 25/147 (17%)

Query: 93  LYNELYVYNTRKDTWTKVDIPSP---------PPRRCAHQAVVVPQGGGQLWVFGGEFAS 143
           L+N+       K  W+++ IP           P  R  HQ V+  Q    +++FGG    
Sbjct: 237 LFNQYISQQEYKPRWSQI-IPKSTKGDGEDNRPGMRGGHQMVIDVQTE-TVYLFGGW--- 291

Query: 144 PNGEQFYHYKDLWVLHLATKTW----EQVKSTGGPSGRSGHRMVA--WKRQLILFGGFHE 197
            +G Q     D W   +    W       +   GPS RS H+M     +RQ+   G + +
Sbjct: 292 -DGTQ--DLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLD 348

Query: 198 ST--RDYIYYNDVYAFNLDTFTWSKLS 222
           S+        +D Y +++DT TW  LS
Sbjct: 349 SSVRNSKSLKSDFYRYDIDTNTWMLLS 375


>gi|223890246 muskelin 1, intracellular mediator containing kelch
           motifs isoform 1 [Homo sapiens]
          Length = 712

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 62/311 (19%), Positives = 111/311 (35%), Gaps = 49/311 (15%)

Query: 61  PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPS-----P 115
           P  R    + +  + + + LFGG  ++G +     + + Y+ +++ WT +   +     P
Sbjct: 245 PGMRGGHQMVIDVQTETVYLFGG--WDGTQDLA--DFWAYSVKENQWTCISRDTEKENGP 300

Query: 116 PPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTW----EQVKST 171
             R C    + + +   Q++  G    S          D +   + T TW    E   + 
Sbjct: 301 SARSCHKMCIDIQRR--QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAAD 358

Query: 172 GGPSGRSGHRMV--AWKRQLILFGG--------FHESTRDYIYYNDVYAFNLDTFTWSKL 221
           GGP     H+M   + K  +  FGG          +S      ++ ++AFN    TW  L
Sbjct: 359 GGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLL 418

Query: 222 SPSGTGPTPRS------GCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPED 275
                   P         C +  +    + V+GG   +    D       SD   +  + 
Sbjct: 419 REDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDG 478

Query: 276 GREDKWVWTRMNPSGVKPTPRSGFS----VAMAPNHQTLFFGGVCDEEEEESLSGEFFND 331
            ++D         SG+   P +GF+    +    N   +  G   D+E+ E       N 
Sbjct: 479 TKKD---------SGM--VPMTGFTQRATIDPELNEIHVLSGLSKDKEKREE---NVRNS 524

Query: 332 LYFYDATRNRW 342
            + YD  RN W
Sbjct: 525 FWIYDIVRNSW 535



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 39/147 (26%), Positives = 61/147 (41%), Gaps = 25/147 (17%)

Query: 93  LYNELYVYNTRKDTWTKVDIPSP---------PPRRCAHQAVVVPQGGGQLWVFGGEFAS 143
           L+N+       K  W+++ IP           P  R  HQ V+  Q    +++FGG    
Sbjct: 214 LFNQYISQQEYKPRWSQI-IPKSTKGDGEDNRPGMRGGHQMVIDVQTE-TVYLFGGW--- 268

Query: 144 PNGEQFYHYKDLWVLHLATKTW----EQVKSTGGPSGRSGHRMVA--WKRQLILFGGFHE 197
            +G Q     D W   +    W       +   GPS RS H+M     +RQ+   G + +
Sbjct: 269 -DGTQ--DLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLD 325

Query: 198 ST--RDYIYYNDVYAFNLDTFTWSKLS 222
           S+        +D Y +++DT TW  LS
Sbjct: 326 SSVRNSKSLKSDFYRYDIDTNTWMLLS 352


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 18/37 (48%), Positives = 23/37 (62%)

Query: 479  EMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEE 515
            E D + +E  EE D E+D E+ EG EG  DD+D G E
Sbjct: 2428 EDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSE 2464


>gi|122937418 similar to poly(A)binding protein nuclear-like 1 [Homo
           sapiens]
          Length = 289

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 472 EAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED 520
           +AW   V  DPE Q W     +  +++E+ G EGG   E+  EE  AE+
Sbjct: 15  QAWLQTVSSDPEAQGW----GAWNETKEILGPEGGEGKEEKEEEEDAEE 59


>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
          Length = 642

 Score = 35.4 bits (80), Expect = 0.13
 Identities = 75/319 (23%), Positives = 113/319 (35%), Gaps = 73/319 (22%)

Query: 59  PPPSPRLNASLSVHPEKDELIL------------FGGEYFNGQKTFL--YNE------LY 98
           P  +P+L+ SLS   ++DELI              G    NG+      YN       + 
Sbjct: 327 PTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVE 386

Query: 99  VYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPN----GEQFYHYKD 154
            YN   D W+ +  P   PR     AV++    GQL+V GG     +    GE +    D
Sbjct: 387 CYNPHTDHWSFL-APMRTPRARFQMAVLM----GQLYVVGGSNGHSDDLSCGEMYDSNID 441

Query: 155 LWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLD 214
            W+     +T            R    + A   +L + GG     +  +   DV  F+  
Sbjct: 442 DWIPVPELRT-----------NRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDV--FDPV 488

Query: 215 TFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPE 274
           T  W+  +P        + C++     G + + GG         V++           PE
Sbjct: 489 TKLWTSCAPLNIRRHQSAVCELG----GYLYIIGGAESWNCLNTVER---------YNPE 535

Query: 275 DGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYF 334
           +       WT + P  V    R G  VA+   +  LF  G  D     S        +  
Sbjct: 536 NN-----TWTLIAPMNV---ARRGAGVAVL--NGKLFVCGGFDGSHAISC-------VEM 578

Query: 335 YDATRNRW-FEGQLKGPKS 352
           YD TRN W   G +  P+S
Sbjct: 579 YDPTRNEWKMMGNMTSPRS 597


>gi|21735415 centromere protein B [Homo sapiens]
          Length = 599

 Score = 34.7 bits (78), Expect = 0.22
 Identities = 44/170 (25%), Positives = 66/170 (38%), Gaps = 45/170 (26%)

Query: 351 KSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQ 410
           + E+++   G +EE EG      GG G +   +   E V E+G V               
Sbjct: 413 EEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEE---EEVEEEGDV--------------- 454

Query: 411 PRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGVLY-VYGGMFEAGDRQVTLSDLHCLDLH 469
               DE+  E+  S + G      A   V+ G  +  YG   EA           C  LH
Sbjct: 455 --DSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEA----------QCPTLH 502

Query: 470 RMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAE 519
            +E  +   + D +++E   E D EED E+        +D+D  EE G E
Sbjct: 503 FLEGGE---DSDSDSEE---EDDEEEDDED--------EDDDDDEEDGDE 538


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
            sapiens]
          Length = 1751

 Score = 34.7 bits (78), Expect = 0.22
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 12/87 (13%)

Query: 348  KGPKSEKKKRRRGRKEEP--EGGSRPACGGA-GTQGPVQLVKEVVAEDGTVVTIKQVLTA 404
            +GPK ++  R  G K +P  +G  +P   G  G  GPV  V E   +DG+V+++      
Sbjct: 1092 QGPKGDRGSR--GEKGDPGKDGVGQPGLPGPPGPPGPVVYVSE---QDGSVLSVPGPEGR 1146

Query: 405  PGSAGQP----RSEDEDSLEEAGSPAP 427
            PG AG P       +  S  E GSP P
Sbjct: 1147 PGFAGFPGPAGPKGNLGSKGERGSPGP 1173


>gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Homo
           sapiens]
          Length = 1336

 Score = 34.7 bits (78), Expect = 0.22
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 12/87 (13%)

Query: 348 KGPKSEKKKRRRGRKEEP--EGGSRPACGGA-GTQGPVQLVKEVVAEDGTVVTIKQVLTA 404
           +GPK ++  R  G K +P  +G  +P   G  G  GPV  V E   +DG+V+++      
Sbjct: 677 QGPKGDRGSR--GEKGDPGKDGVGQPGLPGPPGPPGPVVYVSE---QDGSVLSVPGPEGR 731

Query: 405 PGSAGQP----RSEDEDSLEEAGSPAP 427
           PG AG P       +  S  E GSP P
Sbjct: 732 PGFAGFPGPAGPKGNLGSKGERGSPGP 758


>gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Homo
           sapiens]
          Length = 1516

 Score = 34.7 bits (78), Expect = 0.22
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 12/87 (13%)

Query: 348 KGPKSEKKKRRRGRKEEP--EGGSRPACGGA-GTQGPVQLVKEVVAEDGTVVTIKQVLTA 404
           +GPK ++  R  G K +P  +G  +P   G  G  GPV  V E   +DG+V+++      
Sbjct: 857 QGPKGDRGSR--GEKGDPGKDGVGQPGLPGPPGPPGPVVYVSE---QDGSVLSVPGPEGR 911

Query: 405 PGSAGQP----RSEDEDSLEEAGSPAP 427
           PG AG P       +  S  E GSP P
Sbjct: 912 PGFAGFPGPAGPKGNLGSKGERGSPGP 938


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score = 33.9 bits (76), Expect = 0.37
 Identities = 64/269 (23%), Positives = 98/269 (36%), Gaps = 45/269 (16%)

Query: 76  DELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLW 135
           ++L + GG   +G KT   N +  +N     WT +     PP       + V    G ++
Sbjct: 476 NKLYVVGGR--DGLKTL--NTVECFNPVGKIWTVM-----PPMSTHRHGLGVATLEGPMY 526

Query: 136 VFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGF 195
             GG     +G  + +  + W      + W  V S   P    G  +VA   +L   GG 
Sbjct: 527 AVGGH----DGWSYLNTVERW--DPEGRQWNYVASMSTPRSTVG--VVALNNKLYAIGGR 578

Query: 196 HESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRV 255
             S+        +  F+  T  WS  +P     + R G     T  G + V GG+     
Sbjct: 579 DGSS----CLKSMEYFDPHTNKWSLCAPM----SKRRGGVGVATYNGFLYVVGGHDAPAS 630

Query: 256 KKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGV 315
               +  +R SD   ++  D + D W       S V P      +VA+ P    L+  G 
Sbjct: 631 ----NHCSRLSDC--VERYDPKGDSW-------STVAPLSVPRDAVAVCPLGDKLYVVGG 677

Query: 316 CDEEEEESLSGEFFNDLYFYDATRNRWFE 344
            D          + N +  YDA RN W E
Sbjct: 678 YDGHT-------YLNTVESYDAQRNEWKE 699


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score = 33.9 bits (76), Expect = 0.37
 Identities = 64/269 (23%), Positives = 98/269 (36%), Gaps = 45/269 (16%)

Query: 76  DELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLW 135
           ++L + GG   +G KT   N +  +N     WT +     PP       + V    G ++
Sbjct: 476 NKLYVVGGR--DGLKTL--NTVECFNPVGKIWTVM-----PPMSTHRHGLGVATLEGPMY 526

Query: 136 VFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGF 195
             GG     +G  + +  + W      + W  V S   P    G  +VA   +L   GG 
Sbjct: 527 AVGGH----DGWSYLNTVERW--DPEGRQWNYVASMSTPRSTVG--VVALNNKLYAIGGR 578

Query: 196 HESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRV 255
             S+        +  F+  T  WS  +P     + R G     T  G + V GG+     
Sbjct: 579 DGSS----CLKSMEYFDPHTNKWSLCAPM----SKRRGGVGVATYNGFLYVVGGHDAPAS 630

Query: 256 KKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGV 315
               +  +R SD   ++  D + D W       S V P      +VA+ P    L+  G 
Sbjct: 631 ----NHCSRLSDC--VERYDPKGDSW-------STVAPLSVPRDAVAVCPLGDKLYVVGG 677

Query: 316 CDEEEEESLSGEFFNDLYFYDATRNRWFE 344
            D          + N +  YDA RN W E
Sbjct: 678 YDGHT-------YLNTVESYDAQRNEWKE 699


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 33/123 (26%), Positives = 49/123 (39%), Gaps = 5/123 (4%)

Query: 301 VAMAPNHQTLFFGGVCDEEEEESL-SGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRR 359
           +A + NH   FFG +  EE E+ L  G   + LY    +RN  + G      +  +K   
Sbjct: 6   MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRN--YLGGFALSVAHGRKAHH 63

Query: 360 GRKEEPEGGSRPACGGAGTQGPVQLVKEVVAE-DGTVVTIKQVLTAPGSAGQPRSEDEDS 418
              E    G+    GG     P  L      E DG V  +K+    P    QP++   + 
Sbjct: 64  YTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGV-QPKTGPFED 122

Query: 419 LEE 421
           L+E
Sbjct: 123 LKE 125


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 33/123 (26%), Positives = 49/123 (39%), Gaps = 5/123 (4%)

Query: 301 VAMAPNHQTLFFGGVCDEEEEESL-SGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRR 359
           +A + NH   FFG +  EE E+ L  G   + LY    +RN  + G      +  +K   
Sbjct: 6   MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRN--YLGGFALSVAHGRKAHH 63

Query: 360 GRKEEPEGGSRPACGGAGTQGPVQLVKEVVAE-DGTVVTIKQVLTAPGSAGQPRSEDEDS 418
              E    G+    GG     P  L      E DG V  +K+    P    QP++   + 
Sbjct: 64  YTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGV-QPKTGPFED 122

Query: 419 LEE 421
           L+E
Sbjct: 123 LKE 125


>gi|21450863 attractin isoform 2 [Homo sapiens]
          Length = 1272

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 62/280 (22%), Positives = 103/280 (36%), Gaps = 55/280 (19%)

Query: 82  GGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGG------QLW 135
           GG  FN      YN +  Y+     W         P   +   VVV  G        +++
Sbjct: 357 GGYMFNHSD---YNMVLAYDLASREWL--------PLNRSVNNVVVRYGHSLALYKDKIY 405

Query: 136 VFGGEFASPNGEQFYHYKDLWVLHLATKTW----EQVKSTGGPSGRSGHRMVAWKRQLIL 191
           ++GG+  S          +L V H+  ++W     + K      G S H +     ++++
Sbjct: 406 MYGGKIDSTGNVT----NELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVVM 461

Query: 192 FGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGT---GPTPRSGCQMSVTPQGGIVVYG 248
              F      Y Y ++V  ++LD  TWS L   G    G    S      T    + V+G
Sbjct: 462 LVIFGHCPL-YGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRT--RALYVHG 518

Query: 249 GY-----SKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAM 303
           GY     +K R+  D+ +    + M+ +  +D R  +++ T +  SG             
Sbjct: 519 GYKAFSANKYRLADDLYRYDVDTQMWTIL-KDSRFFRYLHTAVIVSGT------------ 565

Query: 304 APNHQTLFFGGVCDEEEEESLSGE-FFNDLYFYDATRNRW 342
                 L FGG    +   S   + F +D   YD   +RW
Sbjct: 566 -----MLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRW 600


>gi|21450861 attractin isoform 1 [Homo sapiens]
          Length = 1429

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 62/280 (22%), Positives = 103/280 (36%), Gaps = 55/280 (19%)

Query: 82  GGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGG------QLW 135
           GG  FN      YN +  Y+     W         P   +   VVV  G        +++
Sbjct: 357 GGYMFNHSD---YNMVLAYDLASREWL--------PLNRSVNNVVVRYGHSLALYKDKIY 405

Query: 136 VFGGEFASPNGEQFYHYKDLWVLHLATKTW----EQVKSTGGPSGRSGHRMVAWKRQLIL 191
           ++GG+  S          +L V H+  ++W     + K      G S H +     ++++
Sbjct: 406 MYGGKIDSTGNVT----NELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVVM 461

Query: 192 FGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGT---GPTPRSGCQMSVTPQGGIVVYG 248
              F      Y Y ++V  ++LD  TWS L   G    G    S      T    + V+G
Sbjct: 462 LVIFGHCPL-YGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRT--RALYVHG 518

Query: 249 GY-----SKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAM 303
           GY     +K R+  D+ +    + M+ +  +D R  +++ T +  SG             
Sbjct: 519 GYKAFSANKYRLADDLYRYDVDTQMWTIL-KDSRFFRYLHTAVIVSGT------------ 565

Query: 304 APNHQTLFFGGVCDEEEEESLSGE-FFNDLYFYDATRNRW 342
                 L FGG    +   S   + F +D   YD   +RW
Sbjct: 566 -----MLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRW 600


>gi|23397572 kelch-like 34 [Homo sapiens]
          Length = 644

 Score = 33.5 bits (75), Expect = 0.48
 Identities = 73/350 (20%), Positives = 128/350 (36%), Gaps = 62/350 (17%)

Query: 6   KKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRL 65
           ++  +G+ A     + E+++ +   +EE +L   +  F   + +     +LP P      
Sbjct: 302 QRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPL----- 356

Query: 66  NASLSVHPEKDELILFGGEYFNGQKT--------FLYNELYVYNTRKDTWTKVDIPSPPP 117
               SV    + L + GGE  +G  +         +  +++ Y+ R   WT+V     P 
Sbjct: 357 -LGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEV-----PA 410

Query: 118 RRCAHQAVVVPQGGGQLWVFGGEFAS----PNGEQFYHYKDLWVLHLATKTWEQVKSTGG 173
            R A         G +L   GG  A      + E +   +D W     T      ++  G
Sbjct: 411 MREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRW-----TAAGALPRALHG 465

Query: 174 PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSG 233
            +G  G R V +    I  G             D+Y    +   WSK +P GT    R G
Sbjct: 466 HAGAVGDRGVVY----ISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTA---RFG 518

Query: 234 CQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKP 293
             M+V  +G +  + G              R+     ++  D   D+  WTR+     +P
Sbjct: 519 HHMAVL-RGAVFAFLG--------------RYEPFSEIERYDPGADQ--WTRL-----RP 556

Query: 294 TPRSGFSVAMAPNHQT-LFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
            P   F   +A   +T L  GG+   +  +  +     ++  YD   +RW
Sbjct: 557 LPYDRFCYGLAVVEETALLLGGLKWRDSRQVPT----RNVVGYDLDLDRW 602


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 33.1 bits (74), Expect = 0.63
 Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 5/51 (9%)

Query: 470 RMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED 520
           + EA  A V+ + E Q+     + EED  E +G  G  D ++ GEE G ED
Sbjct: 115 KKEAVAAEVKNEEEDQK-----EDEEDQNEEKGEAGKEDKDEKGEEDGKED 160


>gi|42476169 Paf1, RNA polymerase II associated factor, homolog
           [Homo sapiens]
          Length = 531

 Score = 33.1 bits (74), Expect = 0.63
 Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 28/97 (28%)

Query: 433 SNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETD 492
           +NA+L VKH                    D++  +L   EA KA +E     +E  EE +
Sbjct: 345 TNALLVVKH-------------------RDMNEKELEAQEARKAQLENHEPEEEEEEEME 385

Query: 493 SEE------DSEEVEGAEG---GVDDEDSGEESGAED 520
           +EE      D E+ +G+     G +DE SG ES  E+
Sbjct: 386 TEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREE 422


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,699,979
Number of Sequences: 37866
Number of extensions: 1404116
Number of successful extensions: 7604
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 6904
Number of HSP's gapped (non-prelim): 696
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.