Guide to the Human Genome
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Search of human proteins with 213021186

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
         (577 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]        1182   0.0  
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]          1182   0.0  
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]        1077   0.0  
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]        1077   0.0  
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    985   0.0  
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    985   0.0  
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    985   0.0  
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   943   0.0  
gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo ...   187   2e-47
gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo ...   187   2e-47
gi|239754401 PREDICTED: similar to transducin (beta)-like 1 X-li...   151   2e-36
gi|32189425 WD repeat domain 69 [Homo sapiens]                        138   1e-32
gi|26665869 WD repeat domain 51B [Homo sapiens]                       129   7e-30
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]              124   3e-28
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]              124   3e-28
gi|16554629 WD repeat domain 5 [Homo sapiens]                         123   4e-28
gi|16554627 WD repeat domain 5 [Homo sapiens]                         123   4e-28
gi|4757988 WD repeat domain 39 [Homo sapiens]                         123   5e-28
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           120   4e-27
gi|23199987 WD repeat domain 5B [Homo sapiens]                        119   8e-27
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   115   8e-26
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            115   1e-25
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            115   1e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   113   4e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   113   4e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   113   4e-25
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    112   7e-25
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    105   1e-22
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...   105   1e-22
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            103   6e-22

>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 1182 bits (3057), Expect = 0.0
 Identities = 577/577 (100%), Positives = 577/577 (100%)

Query: 1   MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
           MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
Sbjct: 1   MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60

Query: 61  FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
           FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
Sbjct: 61  FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120

Query: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
           GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
Sbjct: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180

Query: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
           GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
Sbjct: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240

Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
           NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300

Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
           TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360

Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
           GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420

Query: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
           DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480

Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
           ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540

Query: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
           HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 1182 bits (3057), Expect = 0.0
 Identities = 577/577 (100%), Positives = 577/577 (100%)

Query: 1   MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
           MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
Sbjct: 1   MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60

Query: 61  FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
           FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
Sbjct: 61  FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120

Query: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
           GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
Sbjct: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180

Query: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
           GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
Sbjct: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240

Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
           NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300

Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
           TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360

Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
           GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420

Query: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
           DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480

Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
           ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540

Query: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
           HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 1077 bits (2785), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA
Sbjct: 61  EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
           ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240

Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
           TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300

Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
           TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360

Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
           TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420

Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
           PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480

Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
           WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 1077 bits (2785), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA
Sbjct: 61  EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
           ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240

Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
           TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300

Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
           TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360

Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
           TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420

Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
           PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480

Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
           WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  985 bits (2546), Expect = 0.0
 Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA  A+A A 
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
           A  AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
           TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298

Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
           TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358

Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
           TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418

Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
           PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478

Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
           WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  985 bits (2546), Expect = 0.0
 Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA  A+A A 
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
           A  AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
           TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298

Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
           TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358

Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
           TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418

Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
           PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478

Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
           WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  985 bits (2546), Expect = 0.0
 Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA  A+A A 
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
           A  AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238

Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
           TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298

Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
           TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358

Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
           TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418

Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
           PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478

Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
           WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  943 bits (2437), Expect = 0.0
 Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)

Query: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60

Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
           EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA   
Sbjct: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118

Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 230
                      S Q  +KN E T NGEEN AH++ NNH   ME+DG+VEIP +KA VLRG
Sbjct: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167

Query: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 290
           HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKD
Sbjct: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227

Query: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 350
           VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287

Query: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410
           KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347

Query: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470
           HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407

Query: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
           NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467

Query: 531 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
           IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514


>gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo
           sapiens]
          Length = 155

 Score =  187 bits (475), Expect = 2e-47
 Identities = 102/154 (66%), Positives = 116/154 (75%), Gaps = 11/154 (7%)

Query: 73  SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
           SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 9   SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67

Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNRE 192
           SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A    +A              +   KN E
Sbjct: 68  SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK---------KKKKKKKNAE 118

Query: 193 ATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKA 225
            T NGEEN AH + NNH   ME+DG++EIP +KA
Sbjct: 119 NTANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 152


>gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo
           sapiens]
          Length = 177

 Score =  187 bits (475), Expect = 2e-47
 Identities = 102/154 (66%), Positives = 116/154 (75%), Gaps = 11/154 (7%)

Query: 73  SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
           SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 31  SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 89

Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNRE 192
           SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A    +A              +   KN E
Sbjct: 90  SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK---------KKKKKKKNAE 140

Query: 193 ATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKA 225
            T NGEEN AH + NNH   ME+DG++EIP +KA
Sbjct: 141 NTANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 174


>gi|239754401 PREDICTED: similar to transducin (beta)-like 1
           X-linked receptor 1 [Homo sapiens]
          Length = 132

 Score =  151 bits (381), Expect = 2e-36
 Identities = 79/98 (80%), Positives = 87/98 (88%), Gaps = 1/98 (1%)

Query: 73  SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
           SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 9   SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67

Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATA 170
           SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A    +A
Sbjct: 68  SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSA 105


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  138 bits (348), Expect = 1e-32
 Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)

Query: 228 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
           L GH + V+  A+N P  D +A+GS D T ++W++              H  R  GH   
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178

Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 345
              ++  L +N   TL+ATGS D  A++W  ++G    TL  H   I +L +N  G+ I+
Sbjct: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235

Query: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 403
           +   D T ++WDA TG        H A   +   +W  +      S D    +      +
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294

Query: 404 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
            V T  GH +E+    +D +G L+A+ S D T +I+S     CI  L+ H  EI  I ++
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354

Query: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 523
           P G        N +L  +S D T R+WD + G C   L  H + ++S AF+  G  + +G
Sbjct: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405

Query: 524 SFDKCVHIW 532
           S D    IW
Sbjct: 406 SKDNTCRIW 414



 Score =  100 bits (250), Expect = 3e-21
 Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)

Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
           L   L  H  P+  +  N+ G+  ++   D+T  +WD  +GE       H      + + 
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 381 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
           N      A+ S D    +  +   +   TF+GHT E+  + ++P   L+A+ S D T K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
           W ++    ++ L+ H+ EI ++ ++ +G           + + SFD TV +WD + G   
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254

Query: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
           + L  H   + S +F+ D   + +GS DK   +W+  +G  V +  G    I + C++  
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314

Query: 558 GDKVGASASDGS 569
           G  +  +++DG+
Sbjct: 315 GKLIATASADGT 326



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)

Query: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
           K  + H   +  +  + SG    + S D T K+W       ++ L+ H   +Y I     
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140

Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
             A +NP  +  +A+ SFD T +LW +E G C HT   H   +  ++F+P    +A+GS 
Sbjct: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197

Query: 526 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
           D    +W+ Q+G  V++ RG +  I  + +N  GD++   + D +V V D
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)

Query: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
           K  +L GH +E+   ++N    L+ +GS D T ++W   + +NG     +        GH
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302

Query: 284 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 342
           D     ++    ++  G L+AT S DG ARI++       + L  H+G I  + +N +GN
Sbjct: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358

Query: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402
           ++L+   DKT  IWDA TG+                              C+ V      
Sbjct: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382

Query: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
                 +GHT+E+ +  ++  G ++ + S D T +IW
Sbjct: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  129 bits (324), Expect = 7e-30
 Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)

Query: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349
           +TSLD + NG  LAT S+D F  +W    +  A     HK  + +++++  GN + SA  
Sbjct: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80

Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408
           D+T  +W         +F  H+AP   VD+  +  F A+ S D  I V  +   R + + 
Sbjct: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140

Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
             HT+ V   K+ P G L+ SCS+D T+KIW    + C+++          + ++P+G  
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200

Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
                    +ASA  D TV++WD+           H   V  ++F P G YL + S D  
Sbjct: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251

Query: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 74/268 (27%), Positives = 124/268 (46%), Gaps = 18/268 (6%)

Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
           P ++A    GH+  V    ++P  +LLAS S D T R+W  ++       +         
Sbjct: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99

Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339
             H  P    V S+D++ +G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154

Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214

Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
           +  ++ ++ +Q H+  VN I + PSG  L + S D TLKI  + +   I+ LQ H   ++
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274

Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
           T+ +S  G   A+   ++ ++L   +FD
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWRTNFD 302



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70

Query: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
            G LLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121

Query: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
            D ++++W + R    ++L +H   V    FSPDG+ + S S DK + IW+T +   V++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181

Query: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576
           +  + G    V +N  G  + ++ SD +V V D+R
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score =  124 bits (310), Expect = 3e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365

Query: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410

Query: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470

Query: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529

Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589

Query: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641

Query: 519 Y-LASGSFDKCVHIWN 533
           + +AS S D  V +W+
Sbjct: 642 FTMASCSRDSTVRLWS 657



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 65/256 (25%), Positives = 116/256 (45%), Gaps = 35/256 (13%)

Query: 302 LLATGSYDGFARIWTEDGNLAS-TLGQHKGPIFALKWNRKGNYILSAGVDKT-TIIWDAH 359
           LLAT S+DG  ++W  +   A  T   ++G I++L W   G   ++ G  +    IW+  
Sbjct: 384 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 443

Query: 360 TGEAKQQFPFHSAPALD-VDWQNNTT--FASCSTD-MCIHVCRLGCDRPVKTFQG----- 410
            G+  Q+F  H    +  + W +  +   A+CS+D  CI          ++T  G     
Sbjct: 444 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 493

Query: 411 --HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPT 465
             H   V    W  +   ++A+  +D  ++++  +   +  +     H  +++ +KWSP 
Sbjct: 494 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553

Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA-SGS 524
                      +L S S D TVR+WD  +  C + L  H  PV  + ++ +  YL  SGS
Sbjct: 554 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 605

Query: 525 FDKCVHIWNTQSGNLV 540
           +D  + +W+T+ G  V
Sbjct: 606 WDYTIKVWDTREGTCV 621



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399

Query: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459

Query: 550 FEVCWNARGDKVGASASDGSVCVL 573
           F + W+ +  K  A+ S    C++
Sbjct: 460 FCIAWSHKDSKRIATCSSDGFCII 483



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 55  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score =  124 bits (310), Expect = 3e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 330 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 389

Query: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 434

Query: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 435 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 494

Query: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 495 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 553

Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 554 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 613

Query: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 614 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 665

Query: 519 Y-LASGSFDKCVHIWN 533
           + +AS S D  V +W+
Sbjct: 666 FTMASCSRDSTVRLWS 681



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 65/256 (25%), Positives = 116/256 (45%), Gaps = 35/256 (13%)

Query: 302 LLATGSYDGFARIWTEDGNLAS-TLGQHKGPIFALKWNRKGNYILSAGVDKT-TIIWDAH 359
           LLAT S+DG  ++W  +   A  T   ++G I++L W   G   ++ G  +    IW+  
Sbjct: 408 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 467

Query: 360 TGEAKQQFPFHSAPALD-VDWQNNTT--FASCSTD-MCIHVCRLGCDRPVKTFQG----- 410
            G+  Q+F  H    +  + W +  +   A+CS+D  CI          ++T  G     
Sbjct: 468 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 517

Query: 411 --HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPT 465
             H   V    W  +   ++A+  +D  ++++  +   +  +     H  +++ +KWSP 
Sbjct: 518 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 577

Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA-SGS 524
                      +L S S D TVR+WD  +  C + L  H  PV  + ++ +  YL  SGS
Sbjct: 578 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 629

Query: 525 FDKCVHIWNTQSGNLV 540
           +D  + +W+T+ G  V
Sbjct: 630 WDYTIKVWDTREGTCV 645



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 378 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 423

Query: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 424 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 483

Query: 550 FEVCWNARGDKVGASASDGSVCVL 573
           F + W+ +  K  A+ S    C++
Sbjct: 484 FCIAWSHKDSKRIATCSSDGFCII 507



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 79  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 138


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  123 bits (309), Expect = 4e-28
 Identities = 77/263 (29%), Positives = 127/263 (48%), Gaps = 15/263 (5%)

Query: 289 KDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
           K V+S+ ++ NG  LA+ S D   +IW   DG    T+  HK  I  + W+   N ++SA
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
             DKT  IWD  +G+  +    HS      ++   +    S S D  + +  +   + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPT 465
           T   H++ V+A+ ++  G L+ S S D   +IW      C+  L    N  +  +K+SP 
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLAS 522
           G           + +A+ D+T++LWD  +G C  T T H+   Y +  +     GK++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 523 GSFDKCVHIWNTQSGNLVHSYRG 545
           GS D  V+IWN Q+  +V   +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299



 Score =  117 bits (293), Expect = 3e-26
 Identities = 63/227 (27%), Positives = 112/227 (49%), Gaps = 11/227 (4%)

Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
           L  TL  H   + ++K++  G ++ S+  DK   IW A+ G+ ++    H     DV W 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
           +++    S S D  + +  +   + +KT +GH+N V    ++P   L+ S S D +++IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
            +K   C+  L AH+  +  + ++  G          ++ S+S+D   R+WD   G C  
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207

Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
           TL     P  S V FSP+GKY+ + + D  + +W+   G  + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254



 Score =  108 bits (270), Expect = 1e-23
 Identities = 81/314 (25%), Positives = 135/314 (42%), Gaps = 29/314 (9%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L GH   V    ++P  + LAS S D   +IW   +    G  +  +       GH +  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI------SGHKL-- 88

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 346
              ++ + W+++  LL + S D   +IW    G    TL  H   +F   +N + N I+S
Sbjct: 89  --GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPV 405
              D++  IWD  TG+  +  P HS P   V + ++ +   S S D    +      + +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206

Query: 406 KTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTI--KW 462
           KT     N  V+ +K+ P+G  + + + D TLK+W   +  C+     H  E Y I   +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266

Query: 463 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
           S TG           + S S D+ V +W+++       L  H + V S A  P    +AS
Sbjct: 267 SVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318

Query: 523 GSF--DKCVHIWNT 534
            +   DK + +W +
Sbjct: 319 AALENDKTIKLWKS 332



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 10/169 (5%)

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
           T  GHT  V+++K+ P+G  LAS S D  +KIW          +  H   I  + WS   
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS--- 96

Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
                 + + +L SAS D T+++WD+  G C  TL  H   V+   F+P    + SGSFD
Sbjct: 97  ------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150

Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
           + V IW+ ++G  + +    +  +  V +N  G  + +S+ DG   + D
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 10/128 (7%)

Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
           L  H K + ++K+SP G           LAS+S D  +++W    G    T++ H+  + 
Sbjct: 41  LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91

Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
            VA+S D   L S S DK + IW+  SG  + + +G       C +N + + + + + D 
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 569 SVCVLDLR 576
           SV + D++
Sbjct: 152 SVRIWDVK 159



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)

Query: 500 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG-GIFEVCWNARG 558
           TL  H + V SV FSP+G++LAS S DK + IW    G    +  G   GI +V W++  
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 559 DKVGASASDGSVCVLDL 575
           + + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  123 bits (309), Expect = 4e-28
 Identities = 77/263 (29%), Positives = 127/263 (48%), Gaps = 15/263 (5%)

Query: 289 KDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
           K V+S+ ++ NG  LA+ S D   +IW   DG    T+  HK  I  + W+   N ++SA
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
             DKT  IWD  +G+  +    HS      ++   +    S S D  + +  +   + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPT 465
           T   H++ V+A+ ++  G L+ S S D   +IW      C+  L    N  +  +K+SP 
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLAS 522
           G           + +A+ D+T++LWD  +G C  T T H+   Y +  +     GK++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 523 GSFDKCVHIWNTQSGNLVHSYRG 545
           GS D  V+IWN Q+  +V   +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299



 Score =  117 bits (293), Expect = 3e-26
 Identities = 63/227 (27%), Positives = 112/227 (49%), Gaps = 11/227 (4%)

Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
           L  TL  H   + ++K++  G ++ S+  DK   IW A+ G+ ++    H     DV W 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
           +++    S S D  + +  +   + +KT +GH+N V    ++P   L+ S S D +++IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
            +K   C+  L AH+  +  + ++  G          ++ S+S+D   R+WD   G C  
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207

Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
           TL     P  S V FSP+GKY+ + + D  + +W+   G  + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254



 Score =  108 bits (270), Expect = 1e-23
 Identities = 81/314 (25%), Positives = 135/314 (42%), Gaps = 29/314 (9%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L GH   V    ++P  + LAS S D   +IW   +    G  +  +       GH +  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI------SGHKL-- 88

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 346
              ++ + W+++  LL + S D   +IW    G    TL  H   +F   +N + N I+S
Sbjct: 89  --GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPV 405
              D++  IWD  TG+  +  P HS P   V + ++ +   S S D    +      + +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206

Query: 406 KTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTI--KW 462
           KT     N  V+ +K+ P+G  + + + D TLK+W   +  C+     H  E Y I   +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266

Query: 463 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
           S TG           + S S D+ V +W+++       L  H + V S A  P    +AS
Sbjct: 267 SVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318

Query: 523 GSF--DKCVHIWNT 534
            +   DK + +W +
Sbjct: 319 AALENDKTIKLWKS 332



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 10/169 (5%)

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
           T  GHT  V+++K+ P+G  LAS S D  +KIW          +  H   I  + WS   
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS--- 96

Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
                 + + +L SAS D T+++WD+  G C  TL  H   V+   F+P    + SGSFD
Sbjct: 97  ------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150

Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
           + V IW+ ++G  + +    +  +  V +N  G  + +S+ DG   + D
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 10/128 (7%)

Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
           L  H K + ++K+SP G           LAS+S D  +++W    G    T++ H+  + 
Sbjct: 41  LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91

Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
            VA+S D   L S S DK + IW+  SG  + + +G       C +N + + + + + D 
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 569 SVCVLDLR 576
           SV + D++
Sbjct: 152 SVRIWDVK 159



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)

Query: 500 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG-GIFEVCWNARG 558
           TL  H + V SV FSP+G++LAS S DK + IW    G    +  G   GI +V W++  
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 559 DKVGASASDGSVCVLDL 575
           + + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score =  123 bits (308), Expect = 5e-28
 Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)

Query: 285 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 338
           VP++ D     L WN  GTLLA+   D   RIW  +G+     S L + H+  +  + W+
Sbjct: 11  VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70

Query: 339 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 398
             GNY+ SA  D TT IW       K Q  F                             
Sbjct: 71  PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97

Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 455
                 V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E    C+  L +H +
Sbjct: 98  ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151

Query: 456 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 513
           ++  + W P         S  +LASAS+D TV+L+  E    VC  TL  H+  V+S+AF
Sbjct: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202

Query: 514 SPDGKYLASGSFDKCVHIW 532
            P G+ LAS S D+ V IW
Sbjct: 203 DPSGQRLASCSDDRTVRIW 221



 Score =  103 bits (256), Expect = 6e-22
 Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)

Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
           +S  +  AWNP   LLAS  GD   RIW    +S       + +  + EG       + V
Sbjct: 16  DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64

Query: 292 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
             + W+  G  LA+ S+D    IW    +D    +TL  H+  + ++ W   GN + +  
Sbjct: 65  RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124

Query: 349 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 404
            DK+  +W+       E       H+     V W  +    AS S D  + + R   D  
Sbjct: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184

Query: 405 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 447
           V   T +GH + V ++ +DPSG  LASCSDD T++IW       +Q V          CI
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244

Query: 448 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 497
             L   H++ IY I W     A         LA+A  D  +R++  +           + 
Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295

Query: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 535
            H    H + V  VA++P +   LAS S D  V  W  Q
Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)

Query: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
           T L GHE+EV   AW P  +LLA+ S D +  +W ++E        ++  H         
Sbjct: 99  TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149

Query: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 342
              +DV  + W+ +  LLA+ SYD   +++ E   D    +TL  H+  +++L ++  G 
Sbjct: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207

Query: 343 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 385
            + S   D+T  IW  +    +Q                   FHS    D+ W Q     
Sbjct: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267

Query: 386 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 435
           A+   D  I V +     D    TF       Q H+ +VN + W+P    LLASCSDD  
Sbjct: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327

Query: 436 LKIWSMKQ 443
           +  W  ++
Sbjct: 328 VAFWKYQR 335



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)

Query: 383 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
           T  ASC  D  I +     D  +      +GH   V  + W P G  LAS S D T  IW
Sbjct: 29  TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88

Query: 440 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 495
              Q+   C+  L+ H  E+ ++ W+P+G          +LA+ S D +V +W+++    
Sbjct: 89  KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139

Query: 496 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 551
             C   L  H + V  V + P  + LAS S+D  V ++  +  + V      G    ++ 
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199

Query: 552 VCWNARGDKVGASASDGSV 570
           + ++  G ++ + + D +V
Sbjct: 200 LAFDPSGQRLASCSDDRTV 218



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)

Query: 511 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 566
           +A++P G  LAS   D+ + IW T+  + +     + G    + +V W+  G+ + +++ 
Sbjct: 22  LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81

Query: 567 DGSVCV 572
           D + C+
Sbjct: 82  DATTCI 87


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  120 bits (300), Expect = 4e-27
 Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L GH   V   A++P    LASGSGD+T R W+L       ST+     C    GH    
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 340
              V S+ W+ +G  LA+G  +G   +W  +    +  TL  H   I  L W     N +
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215

Query: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400
             Y+ S+  D +  IWD   G  ++    H+     + W  +    S S D  I V R  
Sbjct: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275

Query: 401 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 426
                +T QGH + VN +                       D  G L             
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335

Query: 427 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
                   L S SDD TL +WS  + +  +  +  H   I  + +SP          + +
Sbjct: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386

Query: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
           +ASASFD +++LWD   G    +L  H   VY +A+S D + L SGS D  + +W+ ++ 
Sbjct: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446

Query: 538 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
            L     G    ++ V W+  G +V +   D
Sbjct: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)

Query: 228 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
           L GH   +   +W     NP    +AS S D + RIW+    +  G  + +L       G
Sbjct: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244

Query: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 328
           H     + VT L W  +G LL + S D   ++W   DG L  TL  H             
Sbjct: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299

Query: 329 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 358
                              +G +  LK      Y          ++S   D T  +W  A
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359

Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 417
              +   +   H A    V +  ++   AS S D  I +      + + + +GH   V  
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419

Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
           I W     LL S S D TLK+W +K +    DL  H  E+Y + WSP G           
Sbjct: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470

Query: 478 LASASFDSTVRLW 490
           +AS   D  +R+W
Sbjct: 471 VASGGKDKCLRIW 483



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)

Query: 323 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 382
           S+L  H   + ++ ++  G Y+ S   D T   WD                         
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142

Query: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
                           L  + P  T +GH + V +I W P G  LAS   +  + +W   
Sbjct: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186

Query: 443 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 501
               +   L  H+K I  + W    P  +NP     +AS+S D +VR+WD   G C   L
Sbjct: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242

Query: 502 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 547
           T H + V  + +  DG  L S S D+ + +W    G L  + +G G
Sbjct: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)

Query: 446 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 505
           C   L+ H++ + ++ +SPTG           LAS S D+TVR WD+       T   H+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156

Query: 506 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 558
             V S+++SPDG+ LASG  +  + +W+  +G  V      HS   TG  +E +  N   
Sbjct: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216

Query: 559 DKVGASASDGSVCVLD 574
             V +S+ DGSV + D
Sbjct: 217 RYVASSSKDGSVRIWD 232


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  119 bits (298), Expect = 8e-27
 Identities = 65/227 (28%), Positives = 115/227 (50%), Gaps = 11/227 (4%)

Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
           L  TL  H   + ++K++  G ++ S+  D+  IIW A+ G+ ++    H+    DV W 
Sbjct: 33  LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92

Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
           ++++   S S D  + +  +   + +KT +GH+N V    ++P   L+ S S D T+KIW
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152

Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
            +K   C+  L AH+  +  + ++ +G          ++ S S+D   R+WD   G C  
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGS---------LIVSGSYDGLCRIWDAASGQCLK 203

Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
           TL     P  S V FSP+GKY+ + + D  + +W+   G  + +Y G
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250



 Score =  116 bits (290), Expect = 6e-26
 Identities = 76/261 (29%), Positives = 125/261 (47%), Gaps = 15/261 (5%)

Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
           V+S+ ++ NG  LA+ S D    IW   DG    TL  H   I  + W+   + ++SA  
Sbjct: 44  VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103

Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCDRPVKTF 408
           DKT  +WD  +G+  +    HS      ++   +    S S D  + +  +   + +KT 
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163

Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPTGP 467
             H++ V+A+ ++ SG L+ S S D   +IW      C+  L    N  +  +K+SP G 
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223

Query: 468 ATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLASGS 524
                     + +A+ D+T++LWD  RG C  T T H+   Y +  +     GK++ SGS
Sbjct: 224 ---------YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274

Query: 525 FDKCVHIWNTQSGNLVHSYRG 545
            D  V+IWN Q+  +V   +G
Sbjct: 275 EDNLVYIWNLQTKEIVQKLQG 295



 Score =  100 bits (249), Expect = 4e-21
 Identities = 67/221 (30%), Positives = 107/221 (48%), Gaps = 24/221 (10%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 286
           L+GH + VF C +NP S+L+ SGS D T +IW +               C++    H  P
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK-----------CLKTLSAHSDP 169

Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTL-GQHKGPIFALKWNRKGNYI 344
               V+++ +N +G+L+ +GSYDG  RIW    G    TL      P+  +K++  G YI
Sbjct: 170 ----VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225

Query: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT----FASCSTDMCIHVCRLG 400
           L+A +D T  +WD   G   + +  H      +    + T      S S D  +++  L 
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 285

Query: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCS--DDMTLKIW 439
               V+  QGHT+ V +    P+  L+AS +  +D T+K+W
Sbjct: 286 TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 54/169 (31%), Positives = 81/169 (47%), Gaps = 10/169 (5%)

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
           T  GHT  V+++K+ P+G  LAS S D  + IW          L  HN EI  + WS   
Sbjct: 36  TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS--- 92

Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
                 + +  L SAS D T++LWD+  G C  TL  H   V+   F+P    + SGSFD
Sbjct: 93  ------SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146

Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
           + V IW  ++G  + +    +  +  V +N  G  + + + DG   + D
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 10/128 (7%)

Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
           L  H + + ++K+SP G           LAS+S D  + +W    G    TL  H   + 
Sbjct: 37  LVGHTEAVSSVKFSPNGE---------WLASSSADRLIIIWGAYDGKYEKTLYGHNLEIS 87

Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
            VA+S D   L S S DK + +W+ +SG  + + +G       C +N   + + + + D 
Sbjct: 88  DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDE 147

Query: 569 SVCVLDLR 576
           +V + +++
Sbjct: 148 TVKIWEVK 155


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  115 bits (289), Expect = 8e-26
 Identities = 83/318 (26%), Positives = 134/318 (42%), Gaps = 67/318 (21%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L GH S V    ++PV  ++ S S D+T ++W+       G  +  L+      GH    
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK------GH---- 149

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGNYILS 346
              V  + ++ +G LLA+ S D   ++W   G     T+  H   + ++     G++I+S
Sbjct: 150 TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVS 209

Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVK 406
           A  DKT  +W+  TG                                           VK
Sbjct: 210 ASRDKTIKMWEVQTGYC-----------------------------------------VK 228

Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP-- 464
           TF GH   V  ++ +  G L+ASCS+D T+++W +  + C  +L+ H   +  I W+P  
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES 288

Query: 465 --------TGPATSNPNS-NIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP 515
                   TG  T         L S S D T+++WD+  G+C  TL  H   V  V F  
Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS 348

Query: 516 DGKYLASGSFDKCVHIWN 533
            GK++ S + DK + +W+
Sbjct: 349 GGKFILSCADDKTLRVWD 366



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 64/274 (23%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 325 LGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN-T 383
           L  H+ P+  + ++   + ++SA  D T  +WD  TG+ ++    H+    D+ + ++  
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 384 TFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443
             ASCS DM I +        ++T  GH + V+++   P+G  + S S D T+K+W ++ 
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223

Query: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTK 503
             C+     H + +  ++ +  G          ++AS S D TVR+W +    C   L +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGT---------LIASCSNDQTVRVWVVATKECKAELRE 274

Query: 504 HQEPVYSVAFSPD--------------------GKYLASGSFDKCVHIWNTQSGNLVHSY 543
           H+  V  ++++P+                    G +L SGS DK + +W+  +G  + + 
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334

Query: 544 RG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
            G    +  V +++ G  + + A D ++ V D +
Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 69/287 (24%), Positives = 117/287 (40%), Gaps = 47/287 (16%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 286
           L+GH   V   +++    LLAS S D T ++W+                CIR   GHD  
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192

Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYIL 345
              +V+S+    NG  + + S D   ++W  + G    T   H+  +  ++ N+ G  I 
Sbjct: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250

Query: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCST--------------- 390
           S   D+T  +W   T E K +   H      + W   ++++S S                
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310

Query: 391 ------DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444
                 D  I +  +     + T  GH N V  + +   G  + SC+DD TL++W  K +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370

Query: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD 491
            C+  L AH   + ++ +  T P          + + S D TV++W+
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408



 Score = 36.6 bits (83), Expect = 0.065
 Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
           + L+ H+ PV  V F P    + S S D  + +W+ ++G+   + +G T  + ++ ++  
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161

Query: 558 GDKVGASASDGSVCVLDLR 576
           G  + + ++D ++ + D +
Sbjct: 162 GKLLASCSADMTIKLWDFQ 180


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  115 bits (287), Expect = 1e-25
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)

Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
           VT +D++ N   LA+GS D    +W  +  + A     HK  +  + ++  G+ + S   
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408
           DKT  IW  +       F  H+A    V +  +  +F + S D  + V      + + + 
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
             H N V   K+ P G L+ S SDD T+K+W      C+H    H   +  + + P+G  
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524
                    +A+A  D+TV++WD+     TH L +H +     V  ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248

Query: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
            D  + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297



 Score =  113 bits (282), Expect = 5e-25
 Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)

Query: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
           +GH   V    ++  +  LASGS DS   +W++   S             R  GH     
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60

Query: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346
           KD VT ++++ +G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120

Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
                V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
           + + P+G           L +AS DST+++ D+  G   +TL  HQ P  +VAFS  G+Y
Sbjct: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 520 LASGSFDKCVHIWNT 534
            ASG  D+ V +W +
Sbjct: 286 FASGGSDEQVMVWKS 300



 Score =  100 bits (248), Expect = 5e-21
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)

Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
           P S+A    GH+  V    ++P   LLASGS D T RIW    N  G ST  V R     
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100

Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
                     V S+ + ++G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
           +   R ++ +Q H+  VN + + PSG  L + S D TLKI  + +   ++ L  H     
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
           T+ +S TG   A+   +  +M+  ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)

Query: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
           ++ F  H      VD+  NT   AS S D C+ V  +        F GH + V  + + P
Sbjct: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
           SG LLAS S D T++IW  ++K E  +   +AH   + ++ +   G +           +
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120

Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
           AS D TV++W   R     +L++H   V    FSPDG+ + S S DK V +W+  S   V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576
           HSY   GG +  V ++  G  + A+  D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)

Query: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376
           ED +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
           +K+W+  ++  +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177

Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  Y+  +  +  + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237

Query: 555 NARGDKVGASASDGSVCVLDL 575
           +  G+ +  ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  115 bits (287), Expect = 1e-25
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)

Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
           VT +D++ N   LA+GS D    +W  +  + A     HK  +  + ++  G+ + S   
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408
           DKT  IW  +       F  H+A    V +  +  +F + S D  + V      + + + 
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
             H N V   K+ P G L+ S SDD T+K+W      C+H    H   +  + + P+G  
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524
                    +A+A  D+TV++WD+     TH L +H +     V  ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248

Query: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
            D  + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297



 Score =  113 bits (282), Expect = 5e-25
 Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)

Query: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
           +GH   V    ++  +  LASGS DS   +W++   S             R  GH     
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60

Query: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346
           KD VT ++++ +G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120

Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
           A  DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +   
Sbjct: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
                V ++  H   V  + + PSG  +A+   D T+K+W ++    +   Q H+  +  
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
           + + P+G           L +AS DST+++ D+  G   +TL  HQ P  +VAFS  G+Y
Sbjct: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 520 LASGSFDKCVHIWNT 534
            ASG  D+ V +W +
Sbjct: 286 FASGGSDEQVMVWKS 300



 Score =  100 bits (248), Expect = 5e-21
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)

Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
           P S+A    GH+  V    ++P   LLASGS D T RIW    N  G ST  V R     
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100

Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
                     V S+ + ++G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
           +   R ++ +Q H+  VN + + PSG  L + S D TLKI  + +   ++ L  H     
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
           T+ +S TG   A+   +  +M+  ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)

Query: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
           ++ F  H      VD+  NT   AS S D C+ V  +        F GH + V  + + P
Sbjct: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
           SG LLAS S D T++IW  ++K E  +   +AH   + ++ +   G +           +
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120

Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
           AS D TV++W   R     +L++H   V    FSPDG+ + S S DK V +W+  S   V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576
           HSY   GG +  V ++  G  + A+  D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)

Query: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376
           ED +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
           V++  +    AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
           +K+W+  ++  +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177

Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554
            C H+  +H   V  V F P G  +A+   D  V +W+ ++  L+  Y+  +  +  + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237

Query: 555 NARGDKVGASASDGSVCVLDL 575
           +  G+ +  ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  113 bits (283), Expect = 4e-25
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)

Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 330

Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389

Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
           ++D  G  + S + D  +K+W  + E C+H LQ H   +Y++++             I +
Sbjct: 390 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 436

Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
            S S D+++R+WD+E G C HTLT HQ     +    +   L SG+ D  V IW+ ++G 
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 494

Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 534



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)

Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
           GE++ P     VL+GH+  V  C      + + SGS D+T ++W+            V  
Sbjct: 250 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 293

Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
            C+R   GH        T   W++     ++ +GS D   ++W  E G    TL  H   
Sbjct: 294 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 345

Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
           +  +  + K   ++S   D T  +WD  TG+       H A    V +       S + D
Sbjct: 346 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 402

Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
             + V     +  + T QGHTN V ++++D  G+ + S S D ++++W ++   CIH L 
Sbjct: 403 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 460

Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
            H                       +I+ IK          PN +             + 
Sbjct: 461 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 520

Query: 480 SASFDSTVRLWDIERG 495
           ++S D TV+LWD++ G
Sbjct: 521 TSSDDGTVKLWDLKTG 536



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
           + SGS D+T R+W++     G    +++ H     C++  G  V S              
Sbjct: 356 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 398

Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
               G+YD   ++W  E      TL  H   +++L+++  G +++S  +D +  +WD  T
Sbjct: 399 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 452

Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
           G        H +    ++ ++N    S + D  + +  +   + ++T QG   H + V  
Sbjct: 453 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 511

Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
           ++++ + ++ +S  DD T+K+W +K    I +L
Sbjct: 512 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 542



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L+GH + V+   ++ +   + SGS D++ R+W++   +           CI    H +  
Sbjct: 419 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 461

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
           ++ +TS        +L +G+ D   +IW  + G    TL    +H+  +  L++N+  N+
Sbjct: 462 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 518

Query: 344 ILSAGVDKTTIIWDAHTGE 362
           ++++  D T  +WD  TGE
Sbjct: 519 VITSSDDGTVKLWDLKTGE 537



 Score = 33.1 bits (74), Expect = 0.71
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)

Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
           T+ G  NR +S+     H     +D  + +      +    L GH+S           ++
Sbjct: 418 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 475

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
           L SG+ DST +IW++               C++           VT L +N N   + T 
Sbjct: 476 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 522

Query: 307 SYDGFARIW 315
           S DG  ++W
Sbjct: 523 SDDGTVKLW 531


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  113 bits (283), Expect = 4e-25
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)

Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448

Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507

Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
           ++D  G  + S + D  +K+W  + E C+H LQ H   +Y++++             I +
Sbjct: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554

Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
            S S D+++R+WD+E G C HTLT HQ     +    +   L SG+ D  V IW+ ++G 
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612

Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)

Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
           GE++ P     VL+GH+  V  C      + + SGS D+T ++W+            V  
Sbjct: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411

Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
            C+R   GH        T   W++     ++ +GS D   ++W  E G    TL  H   
Sbjct: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463

Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
           +  +  + K   ++S   D T  +WD  TG+       H A    V +       S + D
Sbjct: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520

Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
             + V     +  + T QGHTN V ++++D  G+ + S S D ++++W ++   CIH L 
Sbjct: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 578

Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
            H                       +I+ IK          PN +             + 
Sbjct: 579 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 638

Query: 480 SASFDSTVRLWDIERG 495
           ++S D TV+LWD++ G
Sbjct: 639 TSSDDGTVKLWDLKTG 654



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
           + SGS D+T R+W++     G    +++ H     C++  G  V S              
Sbjct: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516

Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
               G+YD   ++W  E      TL  H   +++L+++  G +++S  +D +  +WD  T
Sbjct: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570

Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
           G        H +    ++ ++N    S + D  + +  +   + ++T QG   H + V  
Sbjct: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629

Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
           ++++ + ++ +S  DD T+K+W +K    I +L
Sbjct: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L+GH + V+   ++ +   + SGS D++ R+W++   +           CI    H +  
Sbjct: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
           ++ +TS        +L +G+ D   +IW  + G    TL    +H+  +  L++N+  N+
Sbjct: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636

Query: 344 ILSAGVDKTTIIWDAHTGE 362
           ++++  D T  +WD  TGE
Sbjct: 637 VITSSDDGTVKLWDLKTGE 655



 Score = 33.1 bits (74), Expect = 0.71
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)

Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
           T+ G  NR +S+     H     +D  + +      +    L GH+S           ++
Sbjct: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
           L SG+ DST +IW++               C++           VT L +N N   + T 
Sbjct: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640

Query: 307 SYDGFARIW 315
           S DG  ++W
Sbjct: 641 SDDGTVKLW 649


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  113 bits (283), Expect = 4e-25
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)

Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 368

Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427

Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
           ++D  G  + S + D  +K+W  + E C+H LQ H   +Y++++             I +
Sbjct: 428 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 474

Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
            S S D+++R+WD+E G C HTLT HQ     +    +   L SG+ D  V IW+ ++G 
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 532

Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 572



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)

Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
           GE++ P     VL+GH+  V  C      + + SGS D+T ++W+            V  
Sbjct: 288 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 331

Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
            C+R   GH        T   W++     ++ +GS D   ++W  E G    TL  H   
Sbjct: 332 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 383

Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
           +  +  + K   ++S   D T  +WD  TG+       H A    V +       S + D
Sbjct: 384 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 440

Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
             + V     +  + T QGHTN V ++++D  G+ + S S D ++++W ++   CIH L 
Sbjct: 441 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 498

Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
            H                       +I+ IK          PN +             + 
Sbjct: 499 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 558

Query: 480 SASFDSTVRLWDIERG 495
           ++S D TV+LWD++ G
Sbjct: 559 TSSDDGTVKLWDLKTG 574



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
           + SGS D+T R+W++     G    +++ H     C++  G  V S              
Sbjct: 394 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 436

Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
               G+YD   ++W  E      TL  H   +++L+++  G +++S  +D +  +WD  T
Sbjct: 437 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 490

Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
           G        H +    ++ ++N    S + D  + +  +   + ++T QG   H + V  
Sbjct: 491 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 549

Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
           ++++ + ++ +S  DD T+K+W +K    I +L
Sbjct: 550 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 580



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
           L+GH + V+   ++ +   + SGS D++ R+W++   +           CI    H +  
Sbjct: 457 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 499

Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
           ++ +TS        +L +G+ D   +IW  + G    TL    +H+  +  L++N+  N+
Sbjct: 500 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 556

Query: 344 ILSAGVDKTTIIWDAHTGE 362
           ++++  D T  +WD  TGE
Sbjct: 557 VITSSDDGTVKLWDLKTGE 575



 Score = 33.1 bits (74), Expect = 0.71
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)

Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
           T+ G  NR +S+     H     +D  + +      +    L GH+S           ++
Sbjct: 456 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 513

Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
           L SG+ DST +IW++               C++           VT L +N N   + T 
Sbjct: 514 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 560

Query: 307 SYDGFARIW 315
           S DG  ++W
Sbjct: 561 SDDGTVKLW 569


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  112 bits (281), Expect = 7e-25
 Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)

Query: 244 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 303
           S L+A G  DST R+W++                         + K + S+   ++ +L+
Sbjct: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516

Query: 304 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576

Query: 363 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 421
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636

Query: 422 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 481
           P+   +A+ S D T+++W +    C+     H   I+++ +SP G           LA+ 
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687

Query: 482 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533
           + D  V LWDI  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 58/208 (27%), Positives = 100/208 (48%), Gaps = 36/208 (17%)

Query: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 464
           +K   GH+  V    + P    L S S+D T+++WS++   C+   + HN  ++  ++SP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595

Query: 465 TGP--------------ATSN--------------------PNSNIMLASASFDSTVRLW 490
            G               AT +                    PNSN + A+ S D TVRLW
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV-ATGSADRTVRLW 654

Query: 491 DIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGI 549
           D+  G C    T H+ P++S+ FSP+G++LA+G+ D  V +W+   G +V   +G T  +
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714

Query: 550 FEVCWNARGDKVGASASDGSVCVLDLRK 577
             + ++  G+ + + + D +V + D  K
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAIK 742



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)

Query: 219 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 278
           E  +S+  +L GH   V+  +++P  + L S S D T R+W+L                +
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579

Query: 279 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 337
              GH+ P    V    ++  G    +G +D  AR+W T+          H   +   ++
Sbjct: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635

Query: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 396
           +   NY+ +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +
Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695

Query: 397 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
             +G    V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 30.4 bits (67), Expect = 4.6
 Identities = 13/33 (39%), Positives = 21/33 (63%)

Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
           L+GH   V    ++   ++LASGS D+T R+W+
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)

Query: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418

Query: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506
           +     H  ++  +K+        +PNSN  LA+ S D TVRLW  ++G      T H+ 
Sbjct: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469

Query: 507 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 565
           PV S+AFSP+GKYLAS   D+ + +W+  SG L    RG T  I  + ++     + +++
Sbjct: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529

Query: 566 SDGSVCVLDLR 576
            D SV V D+R
Sbjct: 530 MDNSVRVWDIR 540



 Score =  100 bits (248), Expect = 5e-21
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)

Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
           +P S LLA+G  +S  ++W+L                ++   H V  ++   + D     
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319

Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373

Query: 361 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419
                 +  H+ P  D+D    +  FAS S D    +       P++ + GH  +V+ +K
Sbjct: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433

Query: 420 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 479
           + P+   LA+ S D T+++WS +Q   +     H   + ++ +SP G           LA
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484

Query: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 536
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)

Query: 213 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 272
           E D E +   ++  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377

Query: 273 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 331
           VL       GH  P    V  LD +      A+GS+D  AR+W+ D      +   H   
Sbjct: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428

Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 390
           +  +K++   NY+ +   DKT  +W A  G + + F  H  P L + +  N  + AS   
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488

Query: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
           D  + +  L      K  +GHT+ + ++ + P   L+AS S D ++++W ++   C    
Sbjct: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548

Query: 451 QAHNKEI 457
              + E+
Sbjct: 549 DGSSSEL 555



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 47/229 (20%), Positives = 79/229 (34%), Gaps = 70/229 (30%)

Query: 415 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 463
           +N  +  P   LLA+  D+  +K+WS++ +      + H  ++  I  +           
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328

Query: 464 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
                         GP  S      +  L S S D ++R WD+     T     H  PV+
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388

Query: 510 S------------------------------------------VAFSPDGKYLASGSFDK 527
                                                      V F P+  YLA+GS DK
Sbjct: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDK 448

Query: 528 CVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 575
            V +W+ Q GN V  + G  G +  + ++  G  + ++  D  + + DL
Sbjct: 449 TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/44 (27%), Positives = 24/44 (54%)

Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539
           +C +     ++ + +   SPD K LA+G  + C+ +W+ +S  L
Sbjct: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score =  105 bits (261), Expect = 1e-22
 Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)

Query: 146 RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 205
           +Q+A R    + Q  +  +  A   A           S ++ +++ +  +  E  + H V
Sbjct: 19  KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78

Query: 206 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 265
             H     ++   +        L+GH ++V    W      + S S D    +W   ++ 
Sbjct: 79  ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135

Query: 266 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 321
                  V   C             V +  +  +G  +A G  D    ++     ++ N+
Sbjct: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184

Query: 322 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 378
           A+   ++  H   + A  +      IL+A  D T  +WD  +G+  Q F  H A  L +D
Sbjct: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244

Query: 379 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
               +   TF S   D    V  +   + V+ F+ H +++N++++ PSG   AS SDD T
Sbjct: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304

Query: 436 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 493
            +++ ++  +EV I+  ++      ++ +S +G          +L +   D T+ +WD+ 
Sbjct: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355

Query: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
           +G     L  H+  V ++  SPDG    SGS+D  + +W
Sbjct: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383
           TL  H   +  + W +    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159

Query: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436
              +C   D    V  L  D+        K+   HTN ++A  +  S M + + S D T 
Sbjct: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219

Query: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272

Query: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332

Query: 554 WNARGDKVGASASDGSVCVLDLRK 577
           ++  G  + A  +D ++ V D+ K
Sbjct: 333 FSLSGRLLFAGYNDYTINVWDVLK 356


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  103 bits (256), Expect = 6e-22
 Identities = 79/291 (27%), Positives = 133/291 (45%), Gaps = 39/291 (13%)

Query: 253 DSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNTNGTLLATGSYDGF 311
           DS   +W++   S             R  GH     KD VT ++++ +G LLA+GS D  
Sbjct: 2   DSCLMVWHMKPQSRA----------YRFTGH-----KDAVTCVNFSPSGHLLASGSRDKT 46

Query: 312 ARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 370
            RIW  +    ST+ + H   + ++ +   G   ++A  DKT  +W  H    +Q+F F 
Sbjct: 47  VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH----RQKFLFS 102

Query: 371 SAPALDVDWQNNTTFA-------SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPS 423
            +    ++W     F+       S S D  + +        V ++  H   V  + + PS
Sbjct: 103 LSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160

Query: 424 GMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
           G  +A+   D T+K+W ++    +   Q H+  +  + + P+G           L +AS 
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN---------YLITASS 211

Query: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNT 534
           DST+++ D+  G   +TL  HQ P  +VAFS  G+Y ASG  D+ V +W +
Sbjct: 212 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262



 Score =  102 bits (255), Expect = 7e-22
 Identities = 66/251 (26%), Positives = 111/251 (44%), Gaps = 19/251 (7%)

Query: 328 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFA 386
           HK  +  + ++  G+ + S   DKT  IW  +       F  H+A    V +  +  +F 
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81

Query: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446
           + S D  + V      + + +   H N V   K+ P G L+ S SDD T+K+W      C
Sbjct: 82  TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141

Query: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506
           +H    H   +  + + P+G           +A+A  D+TV++WD+     TH L +H +
Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188

Query: 507 ----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKV 561
                V  ++F P G YL + S D  + I +   G L+++  G  G    V ++  G+  
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248

Query: 562 GASASDGSVCV 572
            +  SD  V V
Sbjct: 249 ASGGSDEQVMV 259



 Score =  100 bits (248), Expect = 5e-21
 Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)

Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
           P S+A    GH+  V    ++P   LLASGS D T RIW    N  G ST  V R     
Sbjct: 12  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 62

Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
                     V S+ + ++G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 63  -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117

Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177

Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
           +   R ++ +Q H+  VN + + PSG  L + S D TLKI  + +   ++ L  H     
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237

Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
           T+ +S TG   A+   +  +M+  ++FD
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVWKSNFD 265



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 14/189 (7%)

Query: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW--SMKQEVCIH 448
           D C+ V  +        F GH + V  + + PSG LLAS S D T++IW  ++K E  + 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60

Query: 449 DLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPV 508
             +AH   + ++ +   G +           +AS D TV++W   R     +L++H   V
Sbjct: 61  -FRAHTATVRSVHFCSDGQS---------FVTASDDKTVKVWATHRQKFLFSLSQHINWV 110

Query: 509 YSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-IFEVCWNARGDKVGASASD 567
               FSPDG+ + S S DK V +W+  S   VHSY   GG +  V ++  G  + A+  D
Sbjct: 111 RCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 170

Query: 568 GSVCVLDLR 576
            +V V D+R
Sbjct: 171 NTVKVWDVR 179



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 55/229 (24%), Positives = 102/229 (44%), Gaps = 11/229 (4%)

Query: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
           +D   ++W         +F  H      V++  +    AS S D  + +           
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGP 467
           F+ HT  V ++ +   G    + SDD T+K+W+  ++  +  L  H   +   K+SP G 
Sbjct: 61  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 468 ATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDK 527
                    ++ SAS D TV+LWD     C H+  +H   V  V F P G  +A+   D 
Sbjct: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171

Query: 528 CVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
            V +W+ ++  L+  Y+  +  +  + ++  G+ +  ++SD ++ +LDL
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,927,509
Number of Sequences: 37866
Number of extensions: 1044686
Number of successful extensions: 9744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 4764
Number of HSP's gapped (non-prelim): 2301
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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