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Search of human proteins with 21264320
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264320 NLR family, pyrin domain containing 6 [Homo
sapiens]
(892 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 1770 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 429 e-120
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 413 e-115
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 405 e-113
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 405 e-113
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 405 e-113
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 404 e-112
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 329 8e-90
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 314 2e-85
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 314 2e-85
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 314 2e-85
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 301 1e-81
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 296 4e-80
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 296 4e-80
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 261 2e-69
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 255 1e-67
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 245 1e-64
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 244 3e-64
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 244 3e-64
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 241 3e-63
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 241 3e-63
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 228 2e-59
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 212 1e-54
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 186 8e-47
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 119 1e-26
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 119 1e-26
gi|11545912 nucleotide-binding oligomerization domain containing... 108 2e-23
gi|156938336 class II transactivator [Homo sapiens] 106 1e-22
gi|5174617 nucleotide-binding oligomerization domain containing ... 99 2e-20
gi|118918429 NOD3 protein [Homo sapiens] 89 2e-17
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 1770 bits (4584), Expect = 0.0
Identities = 892/892 (100%), Positives = 892/892 (100%)
Query: 1 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPWGRLERAD 60
MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPWGRLERAD
Sbjct: 1 MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPWGRLERAD 60
Query: 61 AVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKK 120
AVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKK
Sbjct: 61 AVDLAEQLAQFYGPEPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKK 120
Query: 121 KYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTH 180
KYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTH
Sbjct: 121 KYREHVLQLHARVKERNARSVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTH 180
Query: 181 TFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGEL 240
TFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGEL
Sbjct: 181 TFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGEL 240
Query: 241 LERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFE 300
LERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFE
Sbjct: 241 LERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFE 300
Query: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYK 360
AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYK
Sbjct: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYK 360
Query: 361 FFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYL 420
FFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYL
Sbjct: 361 FFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYL 420
Query: 421 LFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFL 480
LFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFL
Sbjct: 421 LFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFL 480
Query: 481 SKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHL 540
SKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHL
Sbjct: 481 SKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHL 540
Query: 541 VLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGL 600
VLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGL
Sbjct: 541 VLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGL 600
Query: 601 EDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLS 660
EDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLS
Sbjct: 601 EDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLS 660
Query: 661 YCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLF 720
YCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLF
Sbjct: 661 YCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLF 720
Query: 721 QAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL 780
QAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL
Sbjct: 721 QAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL 780
Query: 781 AWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQG 840
AWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQG
Sbjct: 781 AWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQG 840
Query: 841 CGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPPKELISTF 892
CGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPPKELISTF
Sbjct: 841 CGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPPKELISTF 892
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 429 bits (1103), Expect = e-120
Identities = 301/888 (33%), Positives = 457/888 (51%), Gaps = 80/888 (9%)
Query: 26 LEELSQEQLKRFRHKLRDVGPDGRS-IPWGRLERADAVDLAEQLAQFYGPEPALEVARKT 84
LEEL +LK+F+ L G IPWG +E+A +++A+ L +GPE A +A T
Sbjct: 17 LEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALST 76
Query: 85 LKRADARDVAAQLQERRLQR---------LGLGSGTLLSVS------EYKKKYREHVLQL 129
+R + +D+ + Q L R LG S LL VS + ++ YR++V +
Sbjct: 77 FERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRK 136
Query: 130 HARVKERNAR---SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRAR----RSDTHTF 182
+++RNAR V ++ R+T+LL+ E + P + + G AR ++
Sbjct: 137 FRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKI 196
Query: 183 NRLFRRDEEGRRP-LTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELL 241
LF DEE P TVV+QG AGIGK+M A K++ DWA GKL+QG+ D+ F++ C E+
Sbjct: 197 ETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMN 256
Query: 242 ERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADEL-PALGGPEAAPCTDPFE 300
+ S+ DLI P+ AP+ +++ P+RLLFI+DG DEL P+ P+ C E
Sbjct: 257 QSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEE 316
Query: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYK 360
+L L+ K LLP LL+TTR A +L L P+ E+ GFS+ ++K+YFYK
Sbjct: 317 KRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYK 376
Query: 361 FFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYL 420
+F + +A + + +V++NE LF +CFVP VCW+VCT L+QQLE G L +TS+TTT+VY+
Sbjct: 377 YFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYM 436
Query: 421 LFITSVLSSAPVADGPRLQ--GDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTL 478
L++ S++ P A PRLQ + R LC LA +G+ ++ F E++L + L G V +
Sbjct: 437 LYLLSLMQPKPGA--PRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV-SA 493
Query: 479 FLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDA-QPH 537
FL+ + E Y FI SFQEF AA+ Y+L++G V LL A
Sbjct: 494 FLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSER 553
Query: 538 SHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGA 597
S L LT+RFLFGLL+ E +E+ VS +K + L+W+Q + Q
Sbjct: 554 SFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ------------- 600
Query: 598 KGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVA 657
+ ++G LE CLYE QE+ F++QAL F + + + +M+
Sbjct: 601 ------SDGSTLQQGS-----LEFFSCLYEIQEEEFIQQALSHFQVIVVSNIA-SKMEHM 648
Query: 658 VLSYCVRCCPAGQALRLISCRLVA-AQEKKKKSLGKR------------LQASLGGGSSS 704
V S+C++ C + Q L L A +++ + S G L A +++
Sbjct: 649 VSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAA 708
Query: 705 QGTTKQLPASLLHP----------LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRA 754
T L L+ L Q + P C L +L L C++ + C DLS AL A
Sbjct: 709 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA 768
Query: 755 APALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRG-LQYLVGMLRQSPA 813
LT + L N + G+ +L EGL PQCR+Q ++++ + G Q + +L +P
Sbjct: 769 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
Query: 814 LTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861
L LDL+G L + LC L+H C L+TL L L+ + EL
Sbjct: 829 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Score = 76.3 bits (186), Expect = 1e-13
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L + + P C L +L L C+L A C LS L+A L EL L N L + GL +L+E
Sbjct: 904 LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
Query: 779 GLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL P CR+Q + + + + L L + LT L L+ L V LC L
Sbjct: 964 GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
H GC L+ L L ++L++ + L A++ KP L I
Sbjct: 1024 HPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
Score = 73.9 bits (180), Expect = 6e-13
Identities = 55/167 (32%), Positives = 83/167 (49%), Gaps = 4/167 (2%)
Query: 716 LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRM 775
L L Q + P+C L +L L C+L A C +L+ L +L EL L N L + G+ +
Sbjct: 844 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLL 903
Query: 776 LSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCA 834
L EGL P C++QT+R+ + + L +L+ + L LDLS L + L
Sbjct: 904 LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
Query: 835 VLQHQGCGLQTLSLASVELSEQSLQELQ---AVKRAKPDLVITHPAL 878
LQH C LQ L L S L+ ++ + L + + DL +T+ AL
Sbjct: 964 GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNAL 1010
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 413 bits (1062), Expect = e-115
Identities = 301/945 (31%), Positives = 462/945 (48%), Gaps = 115/945 (12%)
Query: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
Query: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
G E A +A + RD+ + QE ++ +G
Sbjct: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
Query: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
Query: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
Query: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
Query: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
Query: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Query: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
Query: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
Query: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
Query: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
Query: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
Query: 685 KKKKSLGKRL-----------QASLGGGSSSQGTTKQLPASL------------------ 715
++++ G+ L A+ G G + + +
Sbjct: 692 EEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 751
Query: 716 ------LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLS 769
+ L + LC+L L L + L C LS L LT L L N L
Sbjct: 752 ALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLG 811
Query: 770 EAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSGCQLPAPM 828
+ G+++L EGL P C++Q + + + + L +L S +L L L L
Sbjct: 812 DKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLG 871
Query: 829 VTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
V C VL+ Q C LQ L L+ + + ++ L+ ++ KP+L +
Sbjct: 872 VMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 916
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 405 bits (1042), Expect = e-113
Identities = 294/901 (32%), Positives = 450/901 (49%), Gaps = 102/901 (11%)
Query: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
Query: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
G E A +A + RD+ + QE ++ +G
Sbjct: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
Query: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
Query: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
Query: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
Query: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
Query: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Query: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
Query: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
Query: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
Query: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
Query: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
Query: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAV 744
++++ G+ L ++ + + + C S L + L +
Sbjct: 692 EEEEKEGRHL-------------------DMVQCVLPSSSHAAC---SHGLVNSHLTSSF 729
Query: 745 CRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQYL 804
CR L L + +LTEL L N L + G+R+L E L P C ++ + + +
Sbjct: 730 CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFD 789
Query: 805 VGM-LRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQA 863
+ + L + L LDLS L + LC L+H C L+ L L S L+ Q+L +
Sbjct: 790 ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLAS 849
Query: 864 V 864
V
Sbjct: 850 V 850
Score = 68.9 bits (167), Expect = 2e-11
Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 1/156 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L + +P C+L L L + L C LS L LT L L N L + G+++L E
Sbjct: 875 LCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 934
Query: 779 GLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL P C++Q + + + + L +L S +L L L L V C VL+
Sbjct: 935 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 994
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
Q C LQ L L+ + + ++ L+ ++ KP+L +
Sbjct: 995 QQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
Score = 60.1 bits (144), Expect = 9e-09
Identities = 47/150 (31%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786
LC+L L L C L A C+DL+ L + +LT L + N L ++G+ +L E PQC
Sbjct: 826 LCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 885
Query: 787 VQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGC 841
+Q +L GL L +L + LT L L G L + LC L H C
Sbjct: 886 LQ----KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 941
Query: 842 GLQTLSLASVELSEQSLQELQAVKRAKPDL 871
LQ L L + L+ +L + + L
Sbjct: 942 KLQVLELDNCNLTSHCCWDLSTLLTSSQSL 971
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/69 (36%), Positives = 34/69 (49%)
Query: 804 LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQA 863
L +L S +LT LDLS L P + LC LQH GC ++ L L LS + ++
Sbjct: 733 LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792
Query: 864 VKRAKPDLV 872
V + LV
Sbjct: 793 VLSSNQKLV 801
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 405 bits (1042), Expect = e-113
Identities = 303/947 (31%), Positives = 459/947 (48%), Gaps = 123/947 (12%)
Query: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
Query: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
G E A +A + RD+ + QE ++ +G
Sbjct: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
Query: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
Query: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
Query: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
Query: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
Query: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Query: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
Query: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
Query: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
Query: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
Query: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
Query: 685 KKKKSLGKRL-----------QASLGGGSSSQGTTKQLPASL------------------ 715
++++ G+ L A+ G G + + +
Sbjct: 692 EEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 751
Query: 716 ------LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLS 769
+ L + LC+L L L C L A C+DL+ L + +LT L + N L
Sbjct: 752 ALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALG 811
Query: 770 EAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQL 824
++G+ +L E PQC +Q +L GL L +L + LT L L G L
Sbjct: 812 DSGVAILCEKAKNPQCNLQ----KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTL 867
Query: 825 PAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDL 871
+ LC L H C LQ L L + L+ +L + + L
Sbjct: 868 GDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSL 914
Score = 70.5 bits (171), Expect = 7e-12
Identities = 75/292 (25%), Positives = 119/292 (40%), Gaps = 30/292 (10%)
Query: 606 PEEEEEGEEPNYPLELLYCLYETQEDAFVRQAL---------CRFPELALQR----VRFC 652
P+EEEE E+ L+++ C+ + A L C L L V
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELD 747
Query: 653 RMDVAVLSYCVRCCPAG--------QALRLISCRLVAA--QEKKKKSLGKRLQASLGGGS 702
D A+ + +R G + L L+SC L +A Q+ L G
Sbjct: 748 LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGE 807
Query: 703 SSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELG 762
++ G S + L + +P C+L L L + L C LS L LT L
Sbjct: 808 NALGD------SGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
Query: 763 LLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSG 821
L N L + G+++L EGL P C++Q + + + + L +L S +L L L
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
Query: 822 CQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
L V C VL+ Q C LQ L L+ + + ++ L+ ++ KP+L +
Sbjct: 922 NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 405 bits (1042), Expect = e-113
Identities = 294/901 (32%), Positives = 450/901 (49%), Gaps = 102/901 (11%)
Query: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
Query: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
G E A +A + RD+ + QE ++ +G
Sbjct: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
Query: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
Query: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
Query: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
Query: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
Query: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Query: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
Query: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
Query: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
Query: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
Query: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
Query: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAV 744
++++ G+ L ++ + + + C S L + L +
Sbjct: 692 EEEEKEGRHL-------------------DMVQCVLPSSSHAAC---SHGLVNSHLTSSF 729
Query: 745 CRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQYL 804
CR L L + +LTEL L N L + G+R+L E L P C ++ + + +
Sbjct: 730 CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFD 789
Query: 805 VGM-LRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQA 863
+ + L + L LDLS L + LC L+H C L+ L L S L+ Q+L +
Sbjct: 790 ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLAS 849
Query: 864 V 864
V
Sbjct: 850 V 850
Score = 68.9 bits (167), Expect = 2e-11
Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 1/156 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L + +P C+L L L + L C LS L LT L L N L + G+++L E
Sbjct: 875 LCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 934
Query: 779 GLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL P C++Q + + + + L +L S +L L L L V C VL+
Sbjct: 935 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 994
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
Q C LQ L L+ + + ++ L+ ++ KP+L +
Sbjct: 995 QQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
Score = 60.1 bits (144), Expect = 9e-09
Identities = 47/150 (31%), Positives = 67/150 (44%), Gaps = 9/150 (6%)
Query: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786
LC+L L L C L A C+DL+ L + +LT L + N L ++G+ +L E PQC
Sbjct: 826 LCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 885
Query: 787 VQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGC 841
+Q +L GL L +L + LT L L G L + LC L H C
Sbjct: 886 LQ----KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 941
Query: 842 GLQTLSLASVELSEQSLQELQAVKRAKPDL 871
LQ L L + L+ +L + + L
Sbjct: 942 KLQVLELDNCNLTSHCCWDLSTLLTSSQSL 971
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/69 (36%), Positives = 34/69 (49%)
Query: 804 LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQA 863
L +L S +LT LDLS L P + LC LQH GC ++ L L LS + ++
Sbjct: 733 LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792
Query: 864 VKRAKPDLV 872
V + LV
Sbjct: 793 VLSSNQKLV 801
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 404 bits (1039), Expect = e-112
Identities = 304/943 (32%), Positives = 457/943 (48%), Gaps = 115/943 (12%)
Query: 14 RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71
++A R L LE+L LK+F+ L D P IP G+ E+AD VDLA + F
Sbjct: 2 KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
Query: 72 YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110
G E A +A + RD+ + QE ++ +G
Sbjct: 62 NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
Query: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160
LS +Y+KKYR++V +++RNAR SV + KR+T+L + E + +
Sbjct: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
Query: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215
E E G+ + ++ LF D+E P+ TVV QG AGIGKT+ A+K+
Sbjct: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
Query: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275
+ DWA+G LYQ + D+ F++ C E + RSL DLI+ CPD P+ +++ +P R+L
Sbjct: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
Query: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334
F++DG DEL P CTD +A G +L L+ K LLP A LL+TTR A +L
Sbjct: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
Query: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394
Q L P+ E+ GFS+ +K+YF+K+F DE +A A+ ++ENE LF +CF+P VCWIV
Sbjct: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
Query: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454
CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L + L L LC LA +G+
Sbjct: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
Query: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514
++ F E +L L+ + V + FL ++ E Y FI +FQEF AA+ YLLE
Sbjct: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
Query: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564
+ RT G V LL + +L+ RFLFGL++ ER +E+
Sbjct: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
Query: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624
C +S++++ E L+W+ EV AK L+ +P + LEL YC
Sbjct: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
Query: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684
LYE QE+ FV++A+ FP++ + RMD V S+C+ C ++L L + +E
Sbjct: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
Query: 685 KKKKSLGKRLQ------ASLGGGSSSQG-TTKQLPASLLHPLF------QAMTD------ 725
++++ G+ L S + S G L +S LF Q++T+
Sbjct: 692 EEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDN 751
Query: 726 ----------------PLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLS 769
P C++ L L C L C D+S L + L EL L N L
Sbjct: 752 SLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALG 811
Query: 770 EAGLRMLSEGLAWPQCRVQTV-RVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPM 828
+ G+R+L GL C ++ + V L +L + LT L L G L
Sbjct: 812 DFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKG 871
Query: 829 VTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDL 871
+ LC L H C LQ L L + L+ +L + + L
Sbjct: 872 IKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSL 914
Score = 67.8 bits (164), Expect = 4e-11
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786
LC+L L L + L C LS L LT L L N L + G+++L EGL P C+
Sbjct: 826 LCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
Query: 787 VQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQT 845
+Q + + + + L +L S +L L L L V C VL+ Q C LQ
Sbjct: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
Query: 846 LSLASVELSEQSLQELQAVKRAKPDLVI 873
L L+ + + ++ L+ ++ KP+L +
Sbjct: 946 LGLSEMYFNYETKSALETLQEEKPELTV 973
Score = 43.5 bits (101), Expect = 9e-04
Identities = 24/72 (33%), Positives = 36/72 (50%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L + + P C L L L +C L C DLS L ++ +L +L L +N L + G+ M E
Sbjct: 875 LCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCE 934
Query: 779 GLAWPQCRVQTV 790
L C +Q +
Sbjct: 935 VLKQQSCLLQNL 946
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 329 bits (843), Expect = 8e-90
Identities = 269/873 (30%), Positives = 418/873 (47%), Gaps = 85/873 (9%)
Query: 22 LLAALEELSQEQLKRFRHKLRD-VGPDGRSIPWGRLERADAVDLAEQLAQFYGPEPALEV 80
LL LEEL++E+L F+ L++ + P+ PW +++A DLA + ++Y E A V
Sbjct: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSV 74
Query: 81 ARKTLKRADARDVAAQLQER---RLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERN 137
+ K + + +D+ + +E Q +G E ++ + R+KE
Sbjct: 75 SLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKE-- 132
Query: 138 ARSVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRD-EEGRRPL 196
K + K +A G E+ G A + D LF D + G +P
Sbjct: 133 ----KFCITWDKKSLA----------GKPEDFHHGIAEK-DRKLLEHLFDVDVKTGAQPQ 177
Query: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQ 256
VVLQG AG+GKT +K + DWA G LYQ + + F++ G + + RS A LI
Sbjct: 178 IVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLN-GREINQLKERSFAQLISKD 236
Query: 257 CPDRGAPVPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKA 315
P P+ +++ QP LLFI+D DEL A PE A C D + + ++ LL K
Sbjct: 237 WPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKV 296
Query: 316 LLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFV 375
+LP A LLVTTR RL+ L + E+ G S+ +++Y Y+FF D+R A + + +
Sbjct: 297 MLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSL 356
Query: 376 KENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG 435
K NE LF++C VP VCW CT L+QQ+E G D++ T +TTT+++ +I+S+ + PV G
Sbjct: 357 KSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFT--PVDGG 414
Query: 436 -PRL--QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE 492
P L Q LR LC++A +G+ F + L +L L S V + F+ + E E
Sbjct: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSS-FMDSNIIQKDAEYE 473
Query: 493 VTYQFIDQSFQEFLAALSYLL----EDGGVPRTAAGGVGTLLRGDAQPHSHLVLTTRFLF 548
Y F QEF AA+ Y+L E G + +LL+ + HL FLF
Sbjct: 474 NCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLF 533
Query: 549 GLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEE 608
GLL+ +R++ +ER F C +S ++K + L+ ++ G + + G
Sbjct: 534 GLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNS------DYSPSQLGF-------- 579
Query: 609 EEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFC-RMDVAVLSYCVRCCP 667
LEL +CLYETQ+ AF+ QA+ FP++A + C ++ + V S+C++ C
Sbjct: 580 ----------LELFHCLYETQDKAFISQAMRCFPKVA---INICEKIHLLVSSFCLKHC- 625
Query: 668 AGQALRLISCRLVAAQEKK--KKSL------GKRLQASLGGGSSSQGTTK---------- 709
+ LR I + EKK K SL G R+ S T +
Sbjct: 626 --RCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHS 683
Query: 710 QLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLS 769
L S ++ L + P C L L L PD C+D+S +L L L L + +
Sbjct: 684 NLDKSAMNILHHELRHPNCKLQKLLLKFITFPDG-CQDISTSLIHNKNLMHLDLKGSDIG 742
Query: 770 EAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPM 828
+ G++ L E L P+C++QT+R++ + + L +S +L L+LS L
Sbjct: 743 DNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDG 802
Query: 829 VTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861
V LC L+H C L+ LSL S L+E + L
Sbjct: 803 VQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L +A+ P C+L L+L C L +A C LS AL + LT L L N L + G++++S+
Sbjct: 806 LCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSD 865
Query: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
L QC +++ V + +YL L + +LT LDL L V LC V +
Sbjct: 866 ALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFR 925
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDL 871
H C LQ L L L+ +L +V P+L
Sbjct: 926 HPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/149 (29%), Positives = 71/149 (47%), Gaps = 1/149 (0%)
Query: 726 PLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQC 785
P C+L L L C L +A C DL+ + P L L L +N L + G+++L + L +P C
Sbjct: 927 PSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC 986
Query: 786 RVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQ 844
+Q + ++ Q L L + L ++L+ L + L VL+ C LQ
Sbjct: 987 NIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQ 1046
Query: 845 TLSLASVELSEQSLQELQAVKRAKPDLVI 873
L L E++ + L+AV + P L+I
Sbjct: 1047 VLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
Score = 57.8 bits (138), Expect = 4e-08
Identities = 43/144 (29%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L +A+ P C L +L L C L C ++S AL + +L L L N L + G+++L E
Sbjct: 749 LCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCE 808
Query: 779 GLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
L P+C ++ + ++ + G +YL L + LT L L+ L V + LQ
Sbjct: 809 ALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQ 868
Query: 838 HQGCGLQTLSLASVELSEQSLQEL 861
H C L++L L + S + L
Sbjct: 869 HAQCTLKSLVLRRCHFTSLSSEYL 892
Score = 45.1 bits (105), Expect = 3e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L A+ P C++ L L +C L C+DLS AL L ++ L N L G+ L +
Sbjct: 977 LCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYK 1036
Query: 779 GLAWPQCRVQTV 790
L P+C++Q +
Sbjct: 1037 VLKSPKCKLQVL 1048
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 314 bits (805), Expect = 2e-85
Identities = 248/760 (32%), Positives = 369/760 (48%), Gaps = 83/760 (10%)
Query: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
Query: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
Query: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
Query: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
Query: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
Query: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
Query: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
R++E F C +S+ + ++WV L+ +P
Sbjct: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
Query: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
R V + + L L+ + L G S S K L +
Sbjct: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
Query: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
L+H C L L L LS++ QEL+A+++ KP L+I
Sbjct: 944 EGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 314 bits (805), Expect = 2e-85
Identities = 248/760 (32%), Positives = 369/760 (48%), Gaps = 83/760 (10%)
Query: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
Query: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
Query: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
Query: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
Query: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
Query: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
Query: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
R++E F C +S+ + ++WV L+ +P
Sbjct: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
Query: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
R V + + L L+ + L G S S K L +
Sbjct: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
Query: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
L+H C L L L LS++ QEL+A+++ KP L+I
Sbjct: 944 EGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 314 bits (805), Expect = 2e-85
Identities = 248/760 (32%), Positives = 369/760 (48%), Gaps = 83/760 (10%)
Query: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
Query: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
Query: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
Query: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
Query: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
Query: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
Query: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
R++E F C +S+ + ++WV L+ +P
Sbjct: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
Query: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
R V + + L L+ + L G S S K L +
Sbjct: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
Query: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
L+H C L L L LS++ QEL+A+++ KP L+I
Sbjct: 944 EGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 301 bits (772), Expect = 1e-81
Identities = 243/854 (28%), Positives = 400/854 (46%), Gaps = 89/854 (10%)
Query: 22 LLAALEELSQEQLKRFRHKLRDVGP--DGRSIPWGRLERADAVDLAEQLAQFYGPEPALE 79
L+ LEEL +E+ ++F+ L+ + + + IPW +++A +LA L + Y + A
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
Query: 80 VARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERNAR 139
+ + ++ D +D+ ++ R + Y K Y+ H Q +R+
Sbjct: 71 ITLRIFQKMDRKDLCMKVMRER--------------TGYTKTYQAHAKQKFSRLWS---- 112
Query: 140 SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVV 199
+K T++ + E +E + +RLF E G++P TV+
Sbjct: 113 ----SKSVTEIHLYFEEEVKQE----------------ECDHLDRLFAPKEAGKQPRTVI 152
Query: 200 LQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPD 259
+QGP GIGKT K++ W+ K+++ + + F+ C EL E P T SLADLI + PD
Sbjct: 153 IQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPT-SLADLISREWPD 211
Query: 260 RGAPVPQMLAQPQRLLFILDGADELPA-LGGPEAAPCTDPFEAASGARVLGGLLSKALLP 318
AP+ ++++QP+RLLF++D +EL L P++ C D E +L LL K +LP
Sbjct: 212 PAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLP 271
Query: 319 TALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKEN 378
A LL+ + P L+ ++ + + RGF++ D+ YF FF+D +RA A+ V+E+
Sbjct: 272 EASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRES 331
Query: 379 ETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG--P 436
E LF++C +P +CWI+CT L+Q+++ G+DL+ T ++TTSVY F+ + L + A+G P
Sbjct: 332 EQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFN-LFTPEGAEGPTP 390
Query: 437 RLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQ 496
+ Q L+ LC LA EG+ +F E +L + + + + L L K L E E +Y
Sbjct: 391 QTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPAL-LGTKILLKYGERESSYV 449
Query: 497 FIDQSFQEFLAALSYLLEDG-GVPRTAAGGVGTLLRGDAQP--HSHLVLTTRFLFGLLSA 553
F+ QEF AAL YLL+ P A V LL + + +H + FL GLL+
Sbjct: 450 FLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNK 509
Query: 554 ERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGE 613
+ ++ FG +S+ +KQ ++ + K L + P+ + +
Sbjct: 510 KEQEKLDAFFGFQLSQEIKQ------------------QIHQCLKSLGERGNPQGQVDS- 550
Query: 614 EPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALR 673
L + YCL+E Q+ AFV+QA+ E + +D+ V +YC++ C + + L
Sbjct: 551 -----LAIFYCLFEMQDPAFVKQAVNLLQEANFHIID--NVDLVVSAYCLKYCSSLRKL- 602
Query: 674 LISCRLVAAQEKKKKSLGK----------RLQASLGGGSSSQGTTKQLPASLLHPLFQAM 723
S + V +E + S + + G Q L S +
Sbjct: 603 CFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQL 662
Query: 724 TDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWP 783
P C L L +++ L E L P L L +LS +R L + L +P
Sbjct: 663 RHPSCRLQKLGINNVSFSGQSVL-LFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYP 721
Query: 784 QCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCG 842
V+ + V + L G+L + LT L++S QL V LC L
Sbjct: 722 AGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTG-VPLLCEALCSPDTV 780
Query: 843 LQTLSLASVELSEQ 856
L L LA LSEQ
Sbjct: 781 LVYLMLAFCHLSEQ 794
Score = 67.0 bits (162), Expect = 7e-11
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 716 LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRM 775
L L +A+ P C L SL L C + A C DL+ AL + L L + N + + G+++
Sbjct: 824 LKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQL 883
Query: 776 LSEGLAWPQCRVQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
L L CR++ + ++ + GL + L +L S L L+L+ L V
Sbjct: 884 LCRALTHTDCRLEILGLE----ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVV 939
Query: 831 YLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVIT 874
LC L+H C LQ L L + E++ L A + P+L IT
Sbjct: 940 VLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTIT 983
Score = 51.6 bits (122), Expect = 3e-06
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L +A+T C L L L C L C+DL+ L + L +L L N L G+ +L E
Sbjct: 884 LCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCE 943
Query: 779 GLAWPQCRVQTVRVQLPDPQRGLQ-YLVGMLRQSPALTTLD 818
L P+C +Q + ++ D Q L ++P LT D
Sbjct: 944 ALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
Score = 51.2 bits (121), Expect = 4e-06
Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 1/147 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L +A+ P L L L+ C L + C +SE L ++ L L N L + GL+ L E
Sbjct: 770 LCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCE 829
Query: 779 GLAWPQCRVQTV-RVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
L P C + ++ V+ G + L L + L L + ++ V LC L
Sbjct: 830 ALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALT 889
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAV 864
H C L+ L L L+ ++L +V
Sbjct: 890 HTDCRLEILGLEECGLTSTCCKDLASV 916
Score = 46.2 bits (108), Expect = 1e-04
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Query: 707 TTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHN 766
T +L + L A+ P ++ L L +C L C L+ L LT L + N
Sbjct: 702 TLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCN 761
Query: 767 RLSEAGLRMLSEGLAWPQCRVQTVRVQLPDP-----QRGLQYLVGMLRQSPALTTLDLSG 821
+L + G+ +L E L C TV V L ++ +Y+ ML ++ ++ LDLS
Sbjct: 762 QL-DTGVPLLCEAL----CSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSA 816
Query: 822 CQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
L + LC L+H C L +L L ++ ++L + + +L I
Sbjct: 817 NVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKI 868
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 296 bits (759), Expect = 4e-80
Identities = 240/745 (32%), Positives = 355/745 (47%), Gaps = 83/745 (11%)
Query: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
Query: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
Query: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
Query: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
Query: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
Query: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
Query: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
R++E F C +S+ + ++WV L+ +P
Sbjct: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
Query: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
R V + + L L+ + L G S S K L +
Sbjct: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
Query: 834 AVLQHQGCGLQTLSLASVELSEQSL 858
L+H C L L SV + L
Sbjct: 944 EGLRHPACKLIRLGKPSVMTPTEGL 968
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 296 bits (759), Expect = 4e-80
Identities = 240/745 (32%), Positives = 355/745 (47%), Gaps = 83/745 (11%)
Query: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
Query: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
Query: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
Query: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
Query: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
Query: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
Query: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
R++E F C +S+ + ++WV L+ +P
Sbjct: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
Query: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
R V + + L L+ + L G S S K L +
Sbjct: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
Query: 834 AVLQHQGCGLQTLSLASVELSEQSL 858
L+H C L L SV + L
Sbjct: 944 EGLRHPACKLIRLGKPSVMTPTEGL 968
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 261 bits (667), Expect = 2e-69
Identities = 229/713 (32%), Positives = 336/713 (47%), Gaps = 68/713 (9%)
Query: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQ 256
TVVL GPAG+GKT A+K++ DWA L + +AF++ C EL R G S A+L+
Sbjct: 208 TVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYAFYLSCREL-SRLGPCSFAELVFRD 265
Query: 257 CPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLSKA 315
P+ +P +LAQ +++LF++DG DEL A G +E VL G LL++
Sbjct: 266 WPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRV 325
Query: 316 LLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFV 375
+LP A LLVTTR A L+ P V GF ++D++ YF + F DE +A RA+ +
Sbjct: 326 MLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELM 385
Query: 376 KENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG 435
+ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S G
Sbjct: 386 RSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFPQG 440
Query: 436 PRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTY 495
+L+G LR L LA +G+ + + ++LE+L ++ S ++ LFL L ++ Y
Sbjct: 441 AQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLR-LFLDGDILRQDRVSKGCY 499
Query: 496 QFIDQSFQEFLAALSYLL-----EDGGVPRTAAGGVGTLLRG-DAQPHSHLVLTTRFLFG 549
FI SFQ+FL AL Y L ED G V LL G + + L+ + FG
Sbjct: 500 SFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFG 559
Query: 550 LLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEE 609
L + +R +++E FGC +S +KQE LR C G VT+
Sbjct: 560 LANEKRAKELEATFGCRMSPDIKQELLRC----DISCKGGHSTVTD-------------- 601
Query: 610 EEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAG 669
ELL CLYE+QE+ V++ + +F E++L +DV S+CV+ C
Sbjct: 602 --------LQELLGCLYESQEEELVKEVMAQFKEISL---HLNAVDVVPSSFCVKHCRNL 650
Query: 670 Q--ALRLISCRL---VAAQEKKKK-----------SLGKRLQASLGGGSSSQG---TTKQ 710
Q +L++I L V A E + L + G G
Sbjct: 651 QKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSF 710
Query: 711 LPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSE 770
L ASL+ L + + CHL + + DA R+L ALR +T L L N +
Sbjct: 711 LSASLVRILCEQIASDTCHLQRVVFKNISPADA-HRNLCLALRGHKTVTYLTLQGNDQDD 769
Query: 771 AGLRMLSEGLAWPQCRVQTV-RVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMV 829
L E L P+C ++ + V + L L + +LT ++LS +L
Sbjct: 770 M-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
Query: 830 TYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHP 882
L L+H C LQ LSL + L+E + ++L AV +L TH L +P
Sbjct: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSREL--THLCLAKNP 879
Score = 74.3 bits (181), Expect = 5e-13
Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 5/202 (2%)
Query: 672 LRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLS 731
L L+SC Q+ SL + SL + S A LL + + P C L
Sbjct: 788 LGLVSCS-ATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLL---YTTLRHPKCFLQ 843
Query: 732 SLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVR 791
L+L +C L +A C+DL+ L + LT L L N + G++ L EGL +P+C++QT+
Sbjct: 844 RLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLV 903
Query: 792 VQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLAS 850
+ D G L +L++ +L LDL + + +LC L+ C L+ L L
Sbjct: 904 LWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWG 963
Query: 851 VELSEQSLQELQAVKRAKPDLV 872
+ S ++L + LV
Sbjct: 964 CSIPPFSCEDLCSALSCNQSLV 985
Score = 51.2 bits (121), Expect = 4e-06
Identities = 28/78 (35%), Positives = 42/78 (53%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L +A+ PLC+L L L C +P C DL AL +L L L N L +G++ML E
Sbjct: 945 LCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFE 1004
Query: 779 GLAWPQCRVQTVRVQLPD 796
L ++T+R+++ D
Sbjct: 1005 TLTCSSGTLRTLRLKIDD 1022
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 255 bits (651), Expect = 1e-67
Identities = 221/698 (31%), Positives = 323/698 (46%), Gaps = 49/698 (7%)
Query: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
Query: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
Query: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
Query: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
Query: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
Query: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Query: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
Query: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
Query: 668 AGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPL 727
Q L L + V + L ++S + L S + L +T
Sbjct: 616 DLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRST 675
Query: 728 CHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLL-HNRLSEAGLRMLSEGLAWPQCR 786
CHL + + + PD RD A LT L L H + ML + L +C
Sbjct: 676 CHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCN 734
Query: 787 VQTVRV--QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQ 844
+Q +R+ P++ ++ +L+ + +L L LS L L + LQ
Sbjct: 735 LQYLRLGGHCATPEQWAEFFY-VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQ 793
Query: 845 TLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHP 882
LSL + L+E S ++L AV L TH L +P
Sbjct: 794 MLSLENCRLTEASCKDLAAVLVVSKKL--THLCLAKNP 829
Score = 84.0 bits (206), Expect = 6e-16
Identities = 53/144 (36%), Positives = 81/144 (56%), Gaps = 2/144 (1%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
Query: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
Query: 838 HQGCGLQTLSLASVELSEQSLQEL 861
+ C L+ L L S L Q L
Sbjct: 900 NPNCNLKHLRLWSCSLMPFYCQHL 923
Score = 38.1 bits (87), Expect = 0.037
Identities = 28/109 (25%), Positives = 50/109 (45%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L QA+ +P C+L L L C L C+ L AL + L L L N L ++G+ L
Sbjct: 894 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 953
Query: 779 GLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAP 827
L ++ +R++ + ++ L+ +++ T+D + AP
Sbjct: 954 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAP 1002
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 245 bits (626), Expect = 1e-64
Identities = 183/575 (31%), Positives = 289/575 (50%), Gaps = 59/575 (10%)
Query: 19 RELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQFYGPEP 76
RE LL AL +L + K+ + LRD+ P G LE VDLAE L YG +
Sbjct: 10 REALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKE 69
Query: 77 ALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKER 136
A++V K LK + ++ QL + + +Y++ YREHV L
Sbjct: 70 AVKVVLKGLKVMNLLELVDQLSH-------------ICLHDYREVYREHVRCLE------ 110
Query: 137 NARSVKITKRFTKLLIA--PESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEE-GR 193
+ + R+ ++L+ P S +PE P E E ++ T LF E+
Sbjct: 111 EWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQE------LESVTVEALFDSGEKPSL 164
Query: 194 RPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLI 253
P VVLQG AG GKT A+K++ DWA G LY G+ D+ F++ C E++ ++ L L+
Sbjct: 165 APSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESK-LEQLL 223
Query: 254 LDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGG--- 310
C D APV ++L QP+RLLFILDG DEL PFE R L
Sbjct: 224 FWCCGDNQAPVTEILRQPERLLFILDGFDELQR-----------PFEEKLKKRGLSPKES 272
Query: 311 ----LLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDER 366
L+ + LPT LL+TTR A L+ L + + GFS++++ +YF +F DE+
Sbjct: 273 LLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEK 332
Query: 367 RAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSV 426
+A+RA+ V++N+ L+ C VP +CW+VC+ L+ Q+E G+ + T + +T +++ ++++
Sbjct: 333 QADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTF 392
Query: 427 LSSAPVADGPRLQGD----LRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSK 482
L P DG + LR+LC LA EG+ +R F E EL + L G ++ FLS
Sbjct: 393 L--PPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRL-AAFLSS 449
Query: 483 KELPGVLETEVTYQFIDQSFQEFLAALSYLLED--GGVPRTAAGGVGTLLR-GDAQPHSH 539
+ L + Y F SFQ+F A+SYL+++ + + + V LL + + +
Sbjct: 450 NDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDE 509
Query: 540 LVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQE 574
+ LT +FL + + ++E F +S + Q+
Sbjct: 510 MTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQD 544
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 244 bits (623), Expect = 3e-64
Identities = 225/726 (30%), Positives = 325/726 (44%), Gaps = 77/726 (10%)
Query: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
Query: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
Query: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
Query: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
Query: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
Query: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Query: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
Query: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
Query: 668 AGQALRL--------------------ISCRLVAAQEKKKKSL-GKRLQASLGGGSSSQG 706
Q L L C + ++ L RL SS
Sbjct: 616 DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNS 675
Query: 707 TTKQLPA-------SLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALT 759
K L S + L +T CHL + + + PD RD A LT
Sbjct: 676 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLT 734
Query: 760 ELGLL-HNRLSEAGLRMLSEGLAWPQCRVQTVRV--QLPDPQRGLQYLVGMLRQSPALTT 816
L L H + ML + L +C +Q +R+ P++ ++ +L+ + +L
Sbjct: 735 HLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY-VLKANQSLKH 793
Query: 817 LDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHP 876
L LS L L + LQ LSL + L+E S ++L AV L TH
Sbjct: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL--THL 851
Query: 877 ALDGHP 882
L +P
Sbjct: 852 CLAKNP 857
Score = 84.0 bits (206), Expect = 6e-16
Identities = 53/144 (36%), Positives = 81/144 (56%), Gaps = 2/144 (1%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
Query: 838 HQGCGLQTLSLASVELSEQSLQEL 861
+ C L+ L L S L Q L
Sbjct: 928 NPNCNLKHLRLWSCSLMPFYCQHL 951
Score = 38.1 bits (87), Expect = 0.037
Identities = 28/109 (25%), Positives = 50/109 (45%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L QA+ +P C+L L L C L C+ L AL + L L L N L ++G+ L
Sbjct: 922 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 981
Query: 779 GLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAP 827
L ++ +R++ + ++ L+ +++ T+D + AP
Sbjct: 982 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAP 1030
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 244 bits (623), Expect = 3e-64
Identities = 225/726 (30%), Positives = 325/726 (44%), Gaps = 77/726 (10%)
Query: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
Query: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
Query: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
Query: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
Query: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
Query: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Query: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
Query: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
Query: 668 AGQALRL--------------------ISCRLVAAQEKKKKSL-GKRLQASLGGGSSSQG 706
Q L L C + ++ L RL SS
Sbjct: 616 DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNS 675
Query: 707 TTKQLPA-------SLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALT 759
K L S + L +T CHL + + + PD RD A LT
Sbjct: 676 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLT 734
Query: 760 ELGLL-HNRLSEAGLRMLSEGLAWPQCRVQTVRV--QLPDPQRGLQYLVGMLRQSPALTT 816
L L H + ML + L +C +Q +R+ P++ ++ +L+ + +L
Sbjct: 735 HLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY-VLKANQSLKH 793
Query: 817 LDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHP 876
L LS L L + LQ LSL + L+E S ++L AV L TH
Sbjct: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL--THL 851
Query: 877 ALDGHP 882
L +P
Sbjct: 852 CLAKNP 857
Score = 92.0 bits (227), Expect = 2e-18
Identities = 60/168 (35%), Positives = 93/168 (55%), Gaps = 3/168 (1%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
Query: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPP 885
+ C L+ L L + E + + + L+ VK P L I A G PP
Sbjct: 928 NPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNA-SGATAPP 974
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 241 bits (614), Expect = 3e-63
Identities = 245/952 (25%), Positives = 388/952 (40%), Gaps = 152/952 (15%)
Query: 26 LEELSQEQLKRFRHKLRDVGPDGR--SIPWGRLERADAVDLAEQLAQFYGPEPAL----- 78
L EL +E+ + F+ L+ + SIP +E A+ LA L ++YG A
Sbjct: 69 LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128
Query: 79 -----------EVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVL 127
E AR +KR D A + ++ + + + +
Sbjct: 129 IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188
Query: 128 QLHARVKERNARSVKITKRFTKLLIAPE--SAAPEEALGP---------------AEEPE 170
++ +++ A + + ++ + E +AA E G AEE +
Sbjct: 189 EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEED 248
Query: 171 PGRARRS------DTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKL 224
R+ + + T F D G RP TVVL G +GIGK+ A++I+ WA G L
Sbjct: 249 VRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGL 308
Query: 225 YQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADEL 284
YQG + FF+P E+ +R S+ + I + PD APV +++++P+RLLFI+DG D+L
Sbjct: 309 YQGMFSYVFFLPVREM-QRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDL 367
Query: 285 PALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCA 344
++ + C D E ++ LL K LLP + L+VT R +L+ + SP+
Sbjct: 368 GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYL 427
Query: 345 EVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLEL 404
VRG S + + + E + + R + N L C VP V ++C L+ Q +
Sbjct: 428 LVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVV 487
Query: 405 GRDLSRTSKTTTSVYLLFITSVLSSAPVAD---GPRLQGDLRNLCRLAREGVLGRRAQFA 461
G ++ ++T T ++ F+ L+ V + L+ CR+A EGV R++ F
Sbjct: 488 GESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFD 547
Query: 462 EKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGV--- 518
+L L S+++ LF LP E Y F S Q+F AAL Y+LE +
Sbjct: 548 GDDLMVQGLGESELRALFHMNILLPD-SHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPA 606
Query: 519 --PRTAAGGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEAL 576
P ++ A H H + RFLFGL+S + R +E GC V VKQ+ L
Sbjct: 607 LCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLL 666
Query: 577 RWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQ 636
WV GQ + P L+ +CL+ETQ+ FVR
Sbjct: 667 HWVSLLGQ------------------------QPNATTPGDTLDAFHCLFETQDKEFVRL 702
Query: 637 ALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRL------------ISCRLVAAQE 684
AL F E+ L + +D+ S+C++ CP + +R+ +C +V
Sbjct: 703 ALNSFQEVWLPINQ--NLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWM 760
Query: 685 KKKKSLGKR--------------LQASLGGGSSSQGTTKQLPASLLHPLFQAMT------ 724
+ K + ++ Q LG ++ K L A L HP + T
Sbjct: 761 RDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNA 820
Query: 725 ------------------------------------------DPLCHLSSLTLSHCKLPD 742
P C L SL L C L
Sbjct: 821 QITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTH 880
Query: 743 AVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQ-LPDPQRGL 801
A +S+ L +P+L L L N++++ G+ LS+ L QC +Q + ++ G
Sbjct: 881 ACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGC 940
Query: 802 QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVEL 853
Q L L + +LT L LS L V LC ++ C LQ L L L
Sbjct: 941 QSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL 992
Score = 59.7 bits (143), Expect = 1e-08
Identities = 44/148 (29%), Positives = 64/148 (43%), Gaps = 1/148 (0%)
Query: 718 PLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLS 777
PL A+ C L L L C + C+ L+ AL + +LT L L +N L G+ +L
Sbjct: 913 PLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLC 972
Query: 778 EGLAWPQCRVQTVRV-QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVL 836
+ P C +Q + + Q G +L L + LT L LS + V LC V+
Sbjct: 973 RSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVM 1032
Query: 837 QHQGCGLQTLSLASVELSEQSLQELQAV 864
+ C LQ L L L+ + L V
Sbjct: 1033 REPSCHLQDLELVKCHLTAACCESLSCV 1060
Score = 49.7 bits (117), Expect = 1e-05
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 1/144 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L ++M P C L L L+ C L A C L+ AL LT L L N + + G+++L E
Sbjct: 971 LCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCE 1030
Query: 779 GLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
+ P C +Q + V+ + L ++ +S L +LDL+ L V LC L+
Sbjct: 1031 VMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLK 1090
Query: 838 HQGCGLQTLSLASVELSEQSLQEL 861
+ L L L + L+ + L
Sbjct: 1091 QKNSVLARLGLKACGLTSDCCEAL 1114
Score = 48.1 bits (113), Expect = 4e-05
Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 9/160 (5%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L + M +P CHL L L C L A C LS + + L L L N L + G+ L E
Sbjct: 1028 LCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCE 1087
Query: 779 GLAWPQCRVQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
GL + +V +L GL + L L + LT+L+L + LC
Sbjct: 1088 GLK----QKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLC 1143
Query: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
+ LQ + L + Q + L+ V+ KP +VI
Sbjct: 1144 SAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 241 bits (614), Expect = 3e-63
Identities = 227/858 (26%), Positives = 381/858 (44%), Gaps = 89/858 (10%)
Query: 22 LLAALEELSQEQLKRFRHKLRDVGP--DGRSIPWGRLERADAVDLAEQLAQFYGPEPALE 79
LL L+EL +E+ +F+ L+ + + IPW L++A D+A+ L + Y + A E
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
Query: 80 VARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERNAR 139
V + + +D+ + QE +L YR+H+ + + E+
Sbjct: 71 VTLNLFLQINRKDLWTKAQEEMRNKL--------------NPYRKHMKETFQLIWEKET- 115
Query: 140 SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVV 199
+ + + F K + E +A A ARR TVV
Sbjct: 116 CLHVPEHFYKETMKNEYKELNDAYTAA-------ARRH-------------------TVV 149
Query: 200 LQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPD 259
L+GP GIGKT +K++ DWA G L++ + F FF+ E+ T SL +L+ P+
Sbjct: 150 LEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAET-SLLELLSRDWPE 208
Query: 260 RGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGGLLSKALLPT 319
+ + +QP+R+LFI+DG ++L +A D + +L LL K +LP
Sbjct: 209 SSEKIEDIFSQPERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQKKMLPE 268
Query: 320 ALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENE 379
+ LL+ A + L P+ ++ GFS+ +KK YF FF ++ +A + + FV++N
Sbjct: 269 SSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNG 328
Query: 380 TLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRL- 438
LF LC PF CW+VCT ++Q+LE G DL S+ TT +Y F+T+V + + P++
Sbjct: 329 PLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVN 388
Query: 439 QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFI 498
+ L++LC LA EG+ F+ +L + L S+ +++ + L + F+
Sbjct: 389 RARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESE-GVMWVGMRLLQ---RRGDCFAFM 444
Query: 499 DQSFQEFLAALSYLLE-DGGVPRTAAGGVGTLLRGD-AQPHSHLVLTTRFLFGLLSAERM 556
QEF AA+ YLL+ P A G + L+R QP + L F+FG+ + E +
Sbjct: 445 HLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIV 504
Query: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
+E FG +S+ +KQ E+T+ + L E E +
Sbjct: 505 SMLETSFGFPLSKDLKQ------------------EITQCLESLSQCEADREAIAFQ--- 543
Query: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
EL L+ETQE FV + + F E+ + + +A S+C++ C LR+
Sbjct: 544 ---ELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIA--SFCLKHCQHLTTLRMCV 598
Query: 677 CRLV-----AAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHP----LFQAMTDPL 727
+ + +K + R S+ + + SL P L +A+ P+
Sbjct: 599 ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPV 658
Query: 728 CHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRV 787
C L L + +L +A+ P L L L LS++ +R L E L P C++
Sbjct: 659 CKLRKLIFTSVYFGHD--SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKI 716
Query: 788 QTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTL 846
+ + + D + + +L + L L L L +T LC L+H C L+ L
Sbjct: 717 EELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERL 776
Query: 847 SLASVELSEQSLQELQAV 864
L L+ S + V
Sbjct: 777 MLMYCCLTSVSCDSISEV 794
Score = 75.5 bits (184), Expect = 2e-13
Identities = 61/225 (27%), Positives = 91/225 (40%), Gaps = 20/225 (8%)
Query: 652 CRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQL 711
C ++ +L YC L +SC ++ KSL LG + L
Sbjct: 771 CALERLMLMYC--------CLTSVSCDSISEVLLCSKSLSL---LDLGSNALEDNGVASL 819
Query: 712 PASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEA 771
A+L HP C + L L C L C+D++ L L L L HN + +
Sbjct: 820 CAALKHPG--------CSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDT 871
Query: 772 GLRMLSEGLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
G+R L L P C+++ + +Q P + + L L +L+L L A V
Sbjct: 872 GVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVV 931
Query: 831 YLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITH 875
LC L H C LQ L L E++ + L +V+ P L I+H
Sbjct: 932 VLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISH 976
Score = 69.3 bits (168), Expect = 1e-11
Identities = 49/169 (28%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 697 SLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAP 756
SL G S SQ + L +L HP+ C + L L C + VC D++ L
Sbjct: 691 SLYGTSLSQSDIRHLCETLKHPM--------CKIEELILGKCDISSEVCEDIASVLACNS 742
Query: 757 ALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALT 815
L L L+ N L + G+ +L E L C ++ + + + +L S +L+
Sbjct: 743 KLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLS 802
Query: 816 TLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAV 864
LDL L V LCA L+H GC ++ L L L+ S +++ AV
Sbjct: 803 LLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 228 bits (581), Expect = 2e-59
Identities = 197/716 (27%), Positives = 325/716 (45%), Gaps = 67/716 (9%)
Query: 176 RSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFM 235
+ + RL + + T+VL G AG+GKT A + + WA G L+Q + + F++
Sbjct: 209 KDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYL 268
Query: 236 PCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGG-----P 290
C ++ T + A+LI PD AP+ + ++QP++LLFI+DG +E+
Sbjct: 269 SCHKIRYMKET-TFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLD 327
Query: 291 EAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFS 350
+ +PCTD ++ ++L LL K L+P A LL+T + L+ L +P ++ GF+
Sbjct: 328 DGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFT 387
Query: 351 DKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSR 410
D + YF + F D E+ + +++NETLF C P VCW VC+ L+Q DL
Sbjct: 388 GDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQS 447
Query: 411 TSKTTTSVYLLFITSVLSSAPV--ADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQL 468
++TTTS+Y F +++ S+A V AD G R LC LA EG+ F +++ E
Sbjct: 448 ITQTTTSLYAYFFSNLFSTAEVDLAD-DSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIE 506
Query: 469 ELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPR------TA 522
L + +L+ L + + F SFQEF AA+S++LE+ PR T
Sbjct: 507 GLEVPFIDSLY-EFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEE---PREFPPHSTK 562
Query: 523 AGGVGTLLRGD-AQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQG 581
+ LL+ ++ F FGLL+ R++E C +S RV +E L+W
Sbjct: 563 PQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKW--- 619
Query: 582 QGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRF 641
EE + E + L L +CL+E+QE+ F ++ L R
Sbjct: 620 ---------------------GEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRI 658
Query: 642 PELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGG 701
E+ L + ++ S+C++ C LRL + ++ + K + +
Sbjct: 659 FEVDLNILE--DEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSK-FDSRMHAW 715
Query: 702 SSSQGT-------------TKQLPASLLHPLFQAMTDPLCHLSSLTLSHCK--LPDAVCR 746
+S T +L AS + L A+ +P C + LT CK P+ V +
Sbjct: 716 NSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT---CKSVTPEWVLQ 772
Query: 747 DLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLV 805
DL AL+ LT L N+L + ++ + L C ++ + ++ + Q L
Sbjct: 773 DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLA 831
Query: 806 GMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861
L +T L L +L + LCA L H C L+ L L +L+ + + L
Sbjct: 832 LFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
Score = 65.1 bits (157), Expect = 3e-10
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
+ +A+ C+L L L C L A C+DL+ L + +T L L NRL + G+++L
Sbjct: 801 ILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCA 860
Query: 779 GLAWPQCRVQTVRV---QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAV 835
L P+C ++ + + QL P ++L L Q+ +LT L+LS L V +LC
Sbjct: 861 ALTHPKCALERLELWFCQLAAP--ACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEA 918
Query: 836 LQHQGCGLQTLSLASVELSEQSLQEL 861
L LQ+L+L+ + + EL
Sbjct: 919 LGRPDGNLQSLNLSGCSFTREGCGEL 944
Score = 61.2 bits (147), Expect = 4e-09
Identities = 50/156 (32%), Positives = 70/156 (44%), Gaps = 4/156 (2%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
L A+T P C L L L C+L C+ LS+AL +LT L L N L + G++ L E
Sbjct: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
Query: 779 GLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
L P +Q++ + + G L L + + LDL L V LC L+
Sbjct: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK 977
Query: 838 -HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLV 872
H+ L TL LA L+ Q L +V + LV
Sbjct: 978 PHR--ALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/59 (37%), Positives = 32/59 (54%)
Query: 730 LSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQ 788
L +L L+ C L A C+ L L ++ +L L LL N L G++ML + L CR+Q
Sbjct: 982 LHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQ 1040
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 212 bits (540), Expect = 1e-54
Identities = 185/678 (27%), Positives = 307/678 (45%), Gaps = 89/678 (13%)
Query: 185 LFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERP 244
L + +GR+P TV +QG GIGKT+ AKK++++WA K Y + AF+ C E+ +
Sbjct: 193 LLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEV-NQT 251
Query: 245 GTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPF-EAAS 303
+S ++LI + P V +++++P +LL +LDG +EL + ++ + +
Sbjct: 252 TDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLP 311
Query: 304 GARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFR 363
G+ +L LLSK +LP A LL+ R + + L P + GF+ +K KYF +F
Sbjct: 312 GSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFG 371
Query: 364 DERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFI 423
++ F EN LF++C VP VCW+VC+ L+QQ+E G +L+++ TSV++ +I
Sbjct: 372 HTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYI 431
Query: 424 TSVLSSAPVADGPRL-QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSK 482
+S+ + ++ Q L LC LA + + R+ +++LE+ +L + V T FL
Sbjct: 432 SSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGV-TAFLGM 490
Query: 483 KELPGVLETEVTYQFIDQSFQEFLAALSY------------LLEDGGVPRTAAGGVGTLL 530
L + E Y F +FQEF AAL Y +L + R A
Sbjct: 491 SILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASP----- 545
Query: 531 RGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVA 590
RG SH+ L FLFG L+ +E+ F C VS K++ L+ +
Sbjct: 546 RGSKSYLSHMGL---FLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIP---------- 592
Query: 591 PEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVR 650
L +P G +L YCL+E +E+AFV QAL + ++ L+
Sbjct: 593 ---------LLHKCDPPSPGSGVP-----QLFYCLHEIREEAFVSQALNDYHKVVLRIGN 638
Query: 651 FCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQ 710
+V V ++C++ C Q L + + K SSS ++
Sbjct: 639 --NKEVQVSAFCLKRC---QYLHEVELTVTLNFMNVWKL-----------SSSSHPGSEA 682
Query: 711 LPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSE 770
++ LH +Q DL L L + ++ L
Sbjct: 683 PESNGLHRWWQ-------------------------DLCSVFATNDKLEVLTMTNSVLGP 717
Query: 771 AGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
L+ L+ L PQC++Q + ++ + Q L+G+L + L L++ ++ + V
Sbjct: 718 PFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVK 777
Query: 831 YLCAVLQHQGCGLQTLSL 848
LC VL+ C LQ L L
Sbjct: 778 LLCRVLRSPRCRLQCLRL 795
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 1/146 (0%)
Query: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786
+ L L++ +C L C L+ LR + LT L L N L + G + + L +C
Sbjct: 838 VAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCP 897
Query: 787 VQTVRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQT 845
+Q + ++ D Q ++ L ++ L +LDLS L V LC L++ C LQ
Sbjct: 898 LQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQI 957
Query: 846 LSLASVELSEQSLQELQAVKRAKPDL 871
L L + + Q + ++ R L
Sbjct: 958 LELENCLFTSICCQAMASMLRKNQHL 983
Score = 45.8 bits (107), Expect = 2e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 1/122 (0%)
Query: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
++ A+ C L L L C L C+D+ AL L L L N L + G+ +L E
Sbjct: 887 IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCE 946
Query: 779 GLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
L P C +Q + ++ Q + MLR++ L LDLS + + LC
Sbjct: 947 ALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
Query: 838 HQ 839
Q
Sbjct: 1007 SQ 1008
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 186 bits (472), Expect = 8e-47
Identities = 159/671 (23%), Positives = 283/671 (42%), Gaps = 78/671 (11%)
Query: 196 LTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILD 255
L V L G GKT+ + W G+++Q + + + E+ + + SLA+LI
Sbjct: 147 LNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNS-SLAELIAK 205
Query: 256 QCPDRGAPVPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSK 314
PD AP+ +L+ P++LLFIL+ D + L E+A C++ + +L LL +
Sbjct: 206 DWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKR 265
Query: 315 ALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRF 374
+ P L+++R ++ L C S+ ++ YF FF+D +RA A +
Sbjct: 266 KMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQL 325
Query: 375 VKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSS-APVA 433
V E+E L LC V +CWI CTVL++Q++ GRD +T T ++ F+ L+S A +
Sbjct: 326 VHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLT 385
Query: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
G L+ LC LA G+ F+ ++L + + V L + LP +
Sbjct: 386 ANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKD- 444
Query: 494 TYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVLTTRFLFGLLSA 553
Y+FI + QEF A+++L+ VP + + +S F+FGLL+A
Sbjct: 445 RYKFIHLNVQEFCTAIAFLM---AVPNYLIPSGSREYKEKREQYSDFNQVFTFIFGLLNA 501
Query: 554 ERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGE 613
R + +E FG + ++ +W G + + + E
Sbjct: 502 NRRKILETSFGYQLP---MVDSFKWYS------VGYMKHL---------------DRDPE 537
Query: 614 EPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALR 673
+ + + L YCLYE +E+ FV+ + E+ + D+ V YC+ C + L+
Sbjct: 538 KLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQ--SDKDMMVSLYCLDYCCHLRTLK 595
Query: 674 LISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSL 733
L R+ +E PL + + L
Sbjct: 596 LSVQRIFQNKE---------------------------------PLIRPTASQMKSL--- 619
Query: 734 TLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQ 793
R++ +L EL + N L+ R+LS+ L C+++T+++
Sbjct: 620 ---------VYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLS 670
Query: 794 LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVEL 853
G + L+ L ++ +LT L ++ + M + L +L C + LSL +L
Sbjct: 671 YVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
Query: 854 SEQSLQELQAV 864
+E+ ++
Sbjct: 731 RASECEEIASL 741
Score = 58.9 bits (141), Expect = 2e-08
Identities = 57/227 (25%), Positives = 101/227 (44%), Gaps = 14/227 (6%)
Query: 672 LRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLP--ASLLHPLFQAMTDPLCH 729
L L+ C L A++ ++ SL + GGS + T P + ++ L A+ P C
Sbjct: 723 LSLMKCDLRASECEEIASL------LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCT 776
Query: 730 LSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQT 789
L SL L C L + C L L +P L +L L NRL G+ ++ L +P C+++
Sbjct: 777 LISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEE 836
Query: 790 VRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSL 848
+ + + QY+ ++ + L +L++ ++ + LC L+H C L + L
Sbjct: 837 LHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGL 896
Query: 849 ASVELSEQSLQELQAVKRA-----KPDLVITHPALDGHPQPPKELIS 890
L+ + L +V + +L+ H DG + + LIS
Sbjct: 897 EECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLIS 943
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/152 (28%), Positives = 66/152 (43%), Gaps = 4/152 (2%)
Query: 714 SLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGL 773
SLLH + +P C +S L+L C L + C +++ L + +L +L L N L G+
Sbjct: 707 SLLHDILH---EPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGM 763
Query: 774 RMLSEGLAWPQCR-VQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYL 832
+L + L P C + V V + L +L SP L LDL +L V ++
Sbjct: 764 NILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHV 823
Query: 833 CAVLQHQGCGLQTLSLASVELSEQSLQELQAV 864
L C L+ L L+ S Q + V
Sbjct: 824 TFPLLFPTCQLEELHLSGCFFSSDICQYIAIV 855
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/93 (32%), Positives = 42/93 (45%), Gaps = 1/93 (1%)
Query: 726 PLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQC 785
P C L ++ L C L A CR L+ L L L LL N L G+ L E L P C
Sbjct: 887 PNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDC 946
Query: 786 RVQTVRVQLPDPQRGLQYLVGMLRQ-SPALTTL 817
++ V + L Q L+ +++ P+L L
Sbjct: 947 VLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFL 979
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 119 bits (299), Expect = 1e-26
Identities = 207/850 (24%), Positives = 330/850 (38%), Gaps = 123/850 (14%)
Query: 114 SVSEYKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAP--ESAAPEEALGP----AE 167
S +E +++R ++ + +R+ R R T + + P + P+E L P A
Sbjct: 74 SATEAIQRHRRNLAEWFSRLP-REERQFGPTFALDTVHVDPVIRESTPDELLRPPAELAL 132
Query: 168 EPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQG 227
E +P +A ++LF D GRR TVVL G G GK+ +K++ DW G+L
Sbjct: 133 EHQPPQAGLPPL-ALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAF 191
Query: 228 QVDFAFFMPCGELLE-RPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELP- 285
++ F C +L P SL L+ + +P M A LLF+L G + L
Sbjct: 192 ELLIPF--SCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
Query: 286 --ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQC 343
L G C+DP E A ++ LL K +LP A +LVTTR +A GR+ + +
Sbjct: 250 DFRLAG--TGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVG-RY 306
Query: 344 AEVRGFSDKDKKKYFYKF--------------------FRDERRAERAYRFVKENETLFA 383
E+ GFSD + +K +++ + + + R ++ + + A
Sbjct: 307 GEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAA 366
Query: 384 LCFVPFVCWIVCTV---LRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQG 440
CF+P CW+VC L G+ L TS T+ + L F L S ++ +
Sbjct: 367 ACFLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAY 424
Query: 441 DLRNLCRLAREGVLGRRAQFA--------------EKELEQLELRGSKVQTLFLSKKELP 486
R + +LA EGV R+ F+ E+E + L + FL+ P
Sbjct: 425 AARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
Query: 487 GVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVG---TLLRGDAQPHSHLVL- 542
G T+ F + QE+LAAL +L G+ +T VG L G LVL
Sbjct: 485 G---RAGTFVFTVPAMQEYLAALYIVL---GLRKTTLQKVGKEVAELVGRVGEDVSLVLG 538
Query: 543 ---------TTRFLFGLLSAERMRDIERHFGCMVS---ERVKQE-ALRWVQGQGQGCPGV 589
LF L+ + R FG MV E V Q L + + V
Sbjct: 539 IMAKLLPLRALPLLFNLIKV-----VPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDV 593
Query: 590 APEVTEGAKGLE----DTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPEL- 644
++ G+E +EP E+E E +P+ + L A + Q C L
Sbjct: 594 LDQMGASILGVEGPRRHPDEPPEDEVFE--LFPM-FMGGLLSAHNRAVLAQLGCPIKNLD 650
Query: 645 ALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSS 704
AL+ + + + L V P + L + ++ + L+ G
Sbjct: 651 ALENAQAIKKKLGKLGRQV--LPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRM 708
Query: 705 QGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLL 764
+ A++L A+ + + L+ C+L A R L A +LGL
Sbjct: 709 TPVKCTVVAAVLGSGRHALDE-------VNLASCQLDPAGLRTLLPVFLRA---RKLGLQ 758
Query: 765 HNRLSEAGLRMLSEGLAWPQCRVQTVRV-QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQ 823
N L + L + L QC++ T+R+ P G+ L+ L + ++T L
Sbjct: 759 LNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS----- 813
Query: 824 LPAPMVTYLCAVLQHQGCGLQTLSLASVELS-EQSLQELQAVKRAKPDLVITHPALDGHP 882
L H G G + L L + +L + LQEL D A
Sbjct: 814 ------------LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAARE 861
Query: 883 QPPKELISTF 892
P EL+ +
Sbjct: 862 HPSLELLHLY 871
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 119 bits (298), Expect = 1e-26
Identities = 207/847 (24%), Positives = 329/847 (38%), Gaps = 123/847 (14%)
Query: 114 SVSEYKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAP--ESAAPEEALGP----AE 167
S +E +++R ++ + +R+ R R T + + P + P+E L P A
Sbjct: 74 SATEAIQRHRRNLAEWFSRLP-REERQFGPTFALDTVHVDPVIRESTPDELLRPPAELAL 132
Query: 168 EPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQG 227
E +P +A ++LF D GRR TVVL G G GK+ +K++ DW G+L
Sbjct: 133 EHQPPQAGLPPL-ALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAF 191
Query: 228 QVDFAFFMPCGELLE-RPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELP- 285
++ F C +L P SL L+ + +P M A LLF+L G + L
Sbjct: 192 ELLIPF--SCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
Query: 286 --ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQC 343
L G C+DP E A ++ LL K +LP A +LVTTR +A GR+ + +
Sbjct: 250 DFRLAG--TGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVG-RY 306
Query: 344 AEVRGFSDKDKKKYFYKF--------------------FRDERRAERAYRFVKENETLFA 383
E+ GFSD + +K +++ + + + R ++ + + A
Sbjct: 307 GEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAA 366
Query: 384 LCFVPFVCWIVCTV---LRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQG 440
CF+P CW+VC L G+ L TS T+ + L F L S ++ +
Sbjct: 367 ACFLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAY 424
Query: 441 DLRNLCRLAREGVLGRRAQFA--------------EKELEQLELRGSKVQTLFLSKKELP 486
R + +LA EGV R+ F+ E+E + L + FL+ P
Sbjct: 425 AARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
Query: 487 GVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVG---TLLRGDAQPHSHLVL- 542
G T+ F + QE+LAAL +L G+ +T VG L G LVL
Sbjct: 485 G---RAGTFVFTVPAMQEYLAALYIVL---GLRKTTLQKVGKEVAELVGRVGEDVSLVLG 538
Query: 543 ---------TTRFLFGLLSAERMRDIERHFGCMVS---ERVKQE-ALRWVQGQGQGCPGV 589
LF L+ + R FG MV E V Q L + + V
Sbjct: 539 IMAKLLPLRALPLLFNLIKV-----VPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDV 593
Query: 590 APEVTEGAKGLE----DTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPEL- 644
++ G+E +EP E+E E +P+ + L A + Q C L
Sbjct: 594 LDQMGASILGVEGPRRHPDEPPEDEVFE--LFPM-FMGGLLSAHNRAVLAQLGCPIKNLD 650
Query: 645 ALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSS 704
AL+ + + + L V P + L + ++ + L+ G
Sbjct: 651 ALENAQAIKKKLGKLGRQV--LPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRM 708
Query: 705 QGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLL 764
+ A++L A+ + + L+ C+L A R L A +LGL
Sbjct: 709 TPVKCTVVAAVLGSGRHALDE-------VNLASCQLDPAGLRTLLPVFLRA---RKLGLQ 758
Query: 765 HNRLSEAGLRMLSEGLAWPQCRVQTVRV-QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQ 823
N L + L + L QC++ T+R+ P G+ L+ L + ++T L
Sbjct: 759 LNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS----- 813
Query: 824 LPAPMVTYLCAVLQHQGCGLQTLSLASVELS-EQSLQELQAVKRAKPDLVITHPALDGHP 882
L H G G + L L + +L + LQEL D A
Sbjct: 814 ------------LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAARE 861
Query: 883 QPPKELI 889
P EL+
Sbjct: 862 HPSLELL 868
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 108 bits (270), Expect = 2e-23
Identities = 164/637 (25%), Positives = 261/637 (40%), Gaps = 88/637 (13%)
Query: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMP--CGELLERPGTRSLADLIL 254
TV++ G AG GK+ +++ WAAG+ +Q +F F P C +L S+ L+
Sbjct: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQ---EFLFVFPFSCRQLQCMAKPLSVRTLLF 350
Query: 255 DQC--PDRGAP--VPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGG 310
+ C PD G +L P R+L DG DE C+ P + S +L
Sbjct: 351 EHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCS-PTDPTSVQTLLFN 409
Query: 311 LLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAER 370
LL LL A +VT+R AA + + ++GFS++ + Y K + A+R
Sbjct: 410 LLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIELYLRKRHHEPGVADR 468
Query: 371 AYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSA 430
R ++E L LC +P W+V + Q+L L + KTTT +YLL + L A
Sbjct: 469 LIRLLQETSALHGLCHLPVFSWMV-SKCHQELLLQE--GGSPKTTTDMYLLILQHFLLHA 525
Query: 431 PVAD------GPR-LQGDLRNLCRLAREGVLGRRA---QFAEKELEQLELRGSKVQTLFL 480
D GP L+G L L L R + G F+ ++L+ ++ + FL
Sbjct: 526 TPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFL 585
Query: 481 --SKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAA--------------- 523
+K +PG + +F+ +FQ F AA YL VP
Sbjct: 586 VRAKGVVPG---STAPLEFLHITFQCFFAAF-YLALSADVPPALLRHLFNCGRPGNSPMA 641
Query: 524 ---------------GGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVS 568
V LL+ A+PH +L +T FL GLLS E H+G +
Sbjct: 642 RLLPTMCIQASEGKDSSVAALLQ-KAEPH-NLQITAAFLAGLLSRE-------HWGLLAE 692
Query: 569 ERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYET 628
+ ++AL Q + C +A + + + E + P + + L+ LYE
Sbjct: 693 CQTSEKALLRRQACARWC--LARSLRKHFHSIPPAAPGEAKSVHAMPGF-IWLIRSLYEM 749
Query: 629 QEDAFVRQALCRFPELALQRVRFCRM---DVAVLSYCVRCCPAGQALRL-ISCRLVAAQE 684
QE+ R+A R + ++ FC + + A L++ ++ AL+L + E
Sbjct: 750 QEERLARKA-ARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVE 808
Query: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLC-HLSSLTLSHCKLPDA 743
+ LG L + S +L LH C L L L + KL D
Sbjct: 809 QLLPCLGVCKALYLRDNNISDRGICKLIECALH----------CEQLQKLALFNNKLTDG 858
Query: 744 VCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL 780
+++ L L L +N ++ AG ++L+EGL
Sbjct: 859 CAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGL 895
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 106 bits (264), Expect = 1e-22
Identities = 201/746 (26%), Positives = 292/746 (39%), Gaps = 151/746 (20%)
Query: 190 EEGRRPL---TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGT 246
+E RRP + + G AG GK+ A + WA G+L Q DF F +PC L RPG
Sbjct: 405 KEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPC-HCLNRPGD 461
Query: 247 R-SLADLILDQCPDRGAPVPQM----LAQPQRLLFILDGADELPALGGPEAAPCTD-PFE 300
L DL+ P ++ L +P R+L ILDG +EL A G + C P E
Sbjct: 462 AYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE 521
Query: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCA-EVRGFSDKDKKKYFY 359
S +L GL K LL LL+T R GRL L E+ GFS + + Y
Sbjct: 522 PCSLRGLLAGLFQKKLLRGCTLLLTARPR--GRLVQSLSKADALFELSGFSMEQAQAYVM 579
Query: 360 KFFRDERRAE---RAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTT 416
++F E RA +++ L + P +C VC + LELG D ++ T T
Sbjct: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
Query: 417 SVYL-LFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKV 475
+Y+ L + L S P G L L +LA E LGRR Q L++ + + V
Sbjct: 639 GLYVGLLGRAALDSPP--------GALAELAKLAWE--LGRRHQ---STLQEDQFPSADV 685
Query: 476 QTLFLSK---KELPGVLETEVTY-QFIDQSFQEFL-AALSYLLEDGGVPRTAAGGVGTLL 530
+T ++K + P E+E+ + F+ Q F L ALS ++D +P+ A L
Sbjct: 686 RTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLA-----LT 740
Query: 531 RGDAQPHSH-LVLTTRFLFGLLSAERMRDIERHFGCMVSERV--KQEAL-RWVQGQGQGC 586
+P+ + L RFL GL+ R + G + V KQ+ L R+++ G
Sbjct: 741 PRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPG- 799
Query: 587 PGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFP-ELA 645
T A+ L LELL+C +E +E + + P L+
Sbjct: 800 -------TLRARQL------------------LELLHCAHEAEEAGIWQHVVQELPGRLS 834
Query: 646 LQRVRFCRMDVAVLSYCVRC--------------CPAG-QALRLISC------------- 677
R D VL + CP+G +L +SC
Sbjct: 835 FLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVA 894
Query: 678 ------------RLVAAQEK------KKKS------LGKRLQASLGGGSSSQGTTKQLPA 713
L AA+EK K KS LGK +Q SSS+ T +LPA
Sbjct: 895 LWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQ-RTRSSSEDTAGELPA 953
Query: 714 --------SLLHPLFQAMTDP-----------LCHLSSLTLSHCKLPDAVCRDLSEALRA 754
L P+ P L HL LS K+ D LS
Sbjct: 954 VRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQ 1013
Query: 755 APALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDP---QRGLQYLVGMLRQS 811
+L L L N +++ G L+E L P +R+ L + G + L +L
Sbjct: 1014 LKSLETLNLSQNNITDLGAYKLAEAL--PSLAASLLRLSLYNNCICDVGAESLARVLPDM 1071
Query: 812 PALTTLDLSGCQLPAPMVTYLCAVLQ 837
+L +D+ + A L A L+
Sbjct: 1072 VSLRVMDVQYNKFTAAGAQQLAASLR 1097
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 99.0 bits (245), Expect = 2e-20
Identities = 173/729 (23%), Positives = 280/729 (38%), Gaps = 105/729 (14%)
Query: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCG--ELLERPGTRSLADLIL 254
T+ + G AG+GK+M +++ WA G+L G V F F C + L DL+
Sbjct: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAG-VKFFFHFRCRMFSCFKESDRLCLQDLLF 255
Query: 255 DQC--PDRGAP--VPQMLAQPQRLLFILDGADELPA-LGGPEAAPCTDPFEAASGARVLG 309
P+R +L P LF DG DEL + L + P+E A +L
Sbjct: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLA 315
Query: 310 GLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAE 369
LLS LL A L+T R G R + +RGFS + Y + F + +
Sbjct: 316 NLLSGKLLKGASKLLTART---GIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQD 372
Query: 370 RAYRFVKENETLFALCFVPFVCWIVCTVL---RQQLELGRDLSRTSKTTTSVYLLFITSV 426
R ++ N L +LC VP CWI+ R E L + T T V+LL
Sbjct: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
Query: 427 LSS------------APVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSK 474
L+ +PV + L +L ++A G+ F ++E++ L+
Sbjct: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
Query: 475 VQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLED-----------------GG 517
+Q FL G + +Y+F + Q F A +L+D G
Sbjct: 493 MQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAG 552
Query: 518 VPRTAA----------GGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMV 567
T+ G G + H T FL GLLS + + + RH
Sbjct: 553 AATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQK-LLRHLVPAA 611
Query: 568 SERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYE 627
+ R K++AL W + + K L + + P + + +L C+YE
Sbjct: 612 ALRRKRKAL-WAH--------LFSSLRGYLKSLPRVQVESFNQVQAMPTF-IWMLRCIYE 661
Query: 628 TQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKK 687
TQ + +LA + + C + L+YC C AL +
Sbjct: 662 TQSQ--------KVGQLAARGI--CA-NYLKLTYCNACSADCSALSFVL----------- 699
Query: 688 KSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRD 747
KRL L + + ++L P F +T L LS ++ D +
Sbjct: 700 HHFPKRLALDLDNNNLNDYGVREL-----QPCFSRLT-------VLRLSVNQITDGGVKV 747
Query: 748 LSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD---PQRGLQYL 804
LSE L +T LGL +N++++ G R +++ L +C+ T ++L G +YL
Sbjct: 748 LSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLT-HLKLGKNKITSEGGKYL 804
Query: 805 VGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAV 864
++ S +++ + + G Q+ L++ L TLSLAS +S + + L
Sbjct: 805 ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP-SLTTLSLASNGISTEGGKSLARA 863
Query: 865 KRAKPDLVI 873
+ L I
Sbjct: 864 LQQNTSLEI 872
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 88.6 bits (218), Expect = 2e-17
Identities = 186/748 (24%), Positives = 288/748 (38%), Gaps = 103/748 (13%)
Query: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLAD-LI 253
P + G AG+GKT + + WA G++ + DF+ +P + AD LI
Sbjct: 138 PRVSITIGVAGMGKTTLVRHFVRLWAHGQVGK---DFSLVLPLTFRDLNTHEKLCADRLI 194
Query: 254 LDQCPDRGAPVPQMLAQPQRLLFILDGADELPA-LGGPEAAPCTDPFEAASGARVLGGLL 312
P G P +A P R L ILDG DE L CTDP + ++ ++
Sbjct: 195 CSVFPHVGEP-SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNII 253
Query: 313 SKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFF-RDERRAERA 371
L P + +T+R +A G++ G L + E+RGF++++ K + F D+
Sbjct: 254 RGNLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFNEEEIKVCLEQMFPEDQALLGWM 312
Query: 372 YRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTS---------KTTTSVYLLF 422
V+ + L+ +C VP C + L SRT +T +Y +
Sbjct: 313 LSQVQADRALYLMCTVPAFCRLTGMALGHLWR-----SRTGPQDAELWPPRTLCELYSWY 367
Query: 423 ITSVLSSAPVADG---PRLQ-------GDLRNLCRLAREGVLGRRAQFAEKELE----QL 468
LS G PR++ + L RLA G+L ++ F E++++ L
Sbjct: 368 FRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDL 427
Query: 469 ELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSY----------LLEDGGV 518
L + FL ++E L + V Y F S QEF+AA Y L + GV
Sbjct: 428 ALLQGAPCSCFLQREE---TLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGV 484
Query: 519 --PRTAAGGVGTLLRGDAQ-----PHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERV 571
PR G T R AQ L + RFL GLLS R G ++++
Sbjct: 485 SWPRL---GFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSP---RVNALLAGSLLAQGE 538
Query: 572 KQEALRWVQGQGQGCPGVAPEVTEGAKG---------LEDTEEPEEEEEGEE-------- 614
Q V QGC + P+ A+ L+ TE EE E
Sbjct: 539 HQAYRTQVAELLQGC--LRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLT 596
Query: 615 -PNYPLELLY-------CLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCC 666
P + L Y C E + Q + + L R R+D V
Sbjct: 597 GPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMEL 656
Query: 667 PAGQALRLISCRL--VAAQEKKKKSLG-KRLQASLGGGSSSQGTTKQLPASLLHPL-FQA 722
G L CR+ ++ E + + G K L SL S T+ L + + P +A
Sbjct: 657 -LGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSL--TSLDLRGNSIGPQGAKA 713
Query: 723 MTDPL---CHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEG 779
+ D L L+SL+L + D R ++EAL + L+ L L N + G + +++
Sbjct: 714 LADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADA 773
Query: 780 LAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQ 839
L + + + G + L L+ + L +LDL + V L L
Sbjct: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL--- 830
Query: 840 GCGLQTLSLASVELSEQSLQELQAVKRA 867
C QTL S+ + S + QA+ A
Sbjct: 831 -CTNQTLLSLSLRENSISPEGAQAIAHA 857
Score = 32.0 bits (71), Expect = 2.6
Identities = 29/103 (28%), Positives = 41/103 (39%), Gaps = 3/103 (2%)
Query: 721 QAMTDPLCH---LSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLS 777
Q M D L L L S + D + L+EAL+ L L L N +S+AG+ L
Sbjct: 768 QRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALM 827
Query: 778 EGLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLS 820
L Q + + G Q + L + L LDL+
Sbjct: 828 GALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLT 870
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,571,288
Number of Sequences: 37866
Number of extensions: 1691915
Number of successful extensions: 7689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 7013
Number of HSP's gapped (non-prelim): 359
length of query: 892
length of database: 18,247,518
effective HSP length: 111
effective length of query: 781
effective length of database: 14,044,392
effective search space: 10968670152
effective search space used: 10968670152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.