Search of human proteins with 21217563

Search of human proteins with 21217563

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21217563 Shaw-related voltage-gated potassium channel
protein 2 isoform KV3.2b [Homo sapiens]
         (638 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21217563 Shaw-related voltage-gated potassium channel protein...  1309   0.0  
gi|21217561 Shaw-related voltage-gated potassium channel protein...  1220   0.0  
gi|24497458 Shaw-related voltage-gated potassium channel protein...  1108   0.0  
gi|24497462 Shaw-related voltage-gated potassium channel protein...   789   0.0  
gi|88758576 Shaw-related voltage-gated potassium channel protein...   787   0.0  
gi|163792201 Shaw-related voltage-gated potassium channel protei...   777   0.0  
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   743   0.0  
gi|24497464 Shaw-related voltage-gated potassium channel protein...   739   0.0  
gi|24497460 Shaw-related voltage-gated potassium channel protein...   689   0.0  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   293   3e-79
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   290   2e-78
gi|119395748 potassium voltage-gated channel subfamily A member ...   258   1e-68
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   257   3e-68
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   251   1e-66
gi|25952092 potassium voltage-gated channel, shaker-related subf...   251   1e-66
gi|20070166 potassium voltage-gated channel, subfamily F, member...   251   1e-66
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   249   5e-66
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   247   3e-65
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   246   5e-65
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   246   6e-65
gi|88758565 potassium voltage-gated channel, shaker-related subf...   245   8e-65
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   245   1e-64
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   242   9e-64
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   241   2e-63
gi|25952087 potassium voltage-gated channel, shaker-related subf...   238   1e-62
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    229   4e-60
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   229   4e-60
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   223   5e-58
gi|27436988 potassium voltage-gated channel, subfamily G, member...   217   2e-56
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   209   5e-54

>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score = 1309 bits (3388), Expect = 0.0
 Identities = 638/638 (100%), Positives = 638/638 (100%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
           LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
           GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180

Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
           DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240

Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
           VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300

Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
           IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360

Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
           LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420

Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480

Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL 540
           SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL 540

Query: 541 SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRS 600
           SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRS
Sbjct: 541 SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRS 600

Query: 601 LNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL 638
           LNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL
Sbjct: 601 LNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL 638


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score = 1220 bits (3157), Expect = 0.0
 Identities = 593/593 (100%), Positives = 593/593 (100%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
           LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
           GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180

Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
           DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240

Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
           VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300

Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
           IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360

Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
           LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420

Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480

Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL 540
           SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVL 540

Query: 541 SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK 593
           SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK
Sbjct: 541 SGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK 593


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score = 1108 bits (2865), Expect = 0.0
 Identities = 538/538 (100%), Positives = 538/538 (100%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
           LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
           GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180

Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
           DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240

Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
           VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300

Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
           IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360

Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
           LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420

Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480

Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538
           SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  789 bits (2038), Expect = 0.0
 Identities = 421/618 (68%), Positives = 471/618 (76%), Gaps = 63/618 (10%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172

Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230

Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290

Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350

Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410

Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470

Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530

Query: 531 RLLEHNR----------SVLSGDDSTGSEPPL----SPPERLPIRRSSTRDKNRRGETCF 576
            ++E  R          +VLS ++  G   PL    +P ER  +RRS+TRD+N++   CF
Sbjct: 531 GMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACF 590

Query: 577 LLTTGDYTCASDGGIRKG 594
           LL+TGDY CA DG +RKG
Sbjct: 591 LLSTGDYACA-DGSVRKG 607


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  787 bits (2032), Expect = 0.0
 Identities = 420/617 (68%), Positives = 470/617 (76%), Gaps = 63/617 (10%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172

Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230

Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290

Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350

Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410

Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470

Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530

Query: 531 RLLEHNR----------SVLSGDDSTGSEPPL----SPPERLPIRRSSTRDKNRRGETCF 576
            ++E  R          +VLS ++  G   PL    +P ER  +RRS+TRD+N++   CF
Sbjct: 531 GMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACF 590

Query: 577 LLTTGDYTCASDGGIRK 593
           LL+TGDY CA DG +RK
Sbjct: 591 LLSTGDYACA-DGSVRK 606


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  777 bits (2006), Expect = 0.0
 Identities = 413/619 (66%), Positives = 456/619 (73%), Gaps = 81/619 (13%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA  +                   
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
               PRA                                 EFFFDRHPGVFA++LNYYRT
Sbjct: 46  FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171
           GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F         + 
Sbjct: 74  GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133

Query: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227
            D  G GD GD ED     KRL + D+     PDG+ G  WRR QPR+WALFEDPYSSR 
Sbjct: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188

Query: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285
           AR++AFASLFFILVSITTFCLETHE FN + NKTE   V NGT V    E ET+  LTY+
Sbjct: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248

Query: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345
           EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308

Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
           FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368

Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
           +GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428

Query: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525
           AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP  PQ  SP +CK+ +N   +STQSDTC
Sbjct: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488

Query: 526 LGKDNRLLEHNR-----------SVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGET 574
                 +LE NR           + L+ +D    +  L+P E LP  RS TR+   R   
Sbjct: 489 PLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRE---RYGP 545

Query: 575 CFLLTTGDYTCASDGGIRK 593
           CFLL+TG+Y C   GG+RK
Sbjct: 546 CFLLSTGEYACPPGGGMRK 564


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  743 bits (1918), Expect = 0.0
 Identities = 389/553 (70%), Positives = 424/553 (76%), Gaps = 67/553 (12%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA  +                   
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
               PRA                                 EFFFDRHPGVFA++LNYYRT
Sbjct: 46  FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171
           GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F         + 
Sbjct: 74  GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133

Query: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227
            D  G GD GD ED     KRL + D+     PDG+ G  WRR QPR+WALFEDPYSSR 
Sbjct: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188

Query: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285
           AR++AFASLFFILVSITTFCLETHE FN + NKTE   V NGT V    E ET+  LTY+
Sbjct: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248

Query: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345
           EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308

Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
           FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368

Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
           +GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428

Query: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525
           AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP  PQ  SP +CK+ +N   +STQSDTC
Sbjct: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488

Query: 526 LGKDNRLLEHNRS 538
                 +LE NR+
Sbjct: 489 PLAQEEILEINRA 501


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  739 bits (1908), Expect = 0.0
 Identities = 390/548 (71%), Positives = 430/548 (78%), Gaps = 48/548 (8%)

Query: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
           M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA  +  G                
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73

Query: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
                   P + G      GG G+  S GG       GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74  --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112

Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
           GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD  G    
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172

Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
              + GDDE +LA +RLG  +  G  G    SG  R  QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230

Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
           ASLFFILVSITTFCLETHEAFNI +N TE   V N TSV  + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290

Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
           WFT EFLVRIV  P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350

Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
           FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410

Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
           DP  ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470

Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
           IVNNFGMYYSLAMAKQKLP+KRKKH+P   Q  SP +CK+E     +ST SDT    ++ 
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530

Query: 531 RLLEHNRS 538
            ++E  R+
Sbjct: 531 GMIERKRA 538


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  689 bits (1778), Expect = 0.0
 Identities = 364/541 (67%), Positives = 394/541 (72%), Gaps = 88/541 (16%)

Query: 9   RVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68
           ++++NVGG RHETYRSTL+TLPGTRLA L   E                           
Sbjct: 89  KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPE--------------------------- 121

Query: 69  PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPAD 128
                                    D+  G  EFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 122 --------------------AAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPAD 161

Query: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG----------D 178
           VCGPLFEEEL FWGIDETDVE CCWMTYRQHRDAEEALD FE PD  G           D
Sbjct: 162 VCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHD 221

Query: 179 PGDDEDLAA------------KRLGIEDAAG-LGGPDGKSGR-----WRRLQPRMWALFE 220
            G D++  A            KRL  +DA G  GGP G +G      WRR QPR+WALFE
Sbjct: 222 GGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFE 281

Query: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKT---------EPVINGTSVV 271
           DPYSSRAAR++AFASLFFIL+SITTFCLETHE F  + NKT          P  N T+V 
Sbjct: 282 DPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV- 340

Query: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
              E+ET+P LTYVEGVCVVWFTFEFL+RI F P+K+EF+K+ LNIID VAILPFYLEVG
Sbjct: 341 ---EVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVG 397

Query: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
           LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL
Sbjct: 398 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 457

Query: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
           GVLIFATMIYYAER+GA P+D   S HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGM
Sbjct: 458 GVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM 517

Query: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKT 511
           LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP+K+ KHIP  PQ  SP +CK 
Sbjct: 518 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKP 577

Query: 512 E 512
           +
Sbjct: 578 D 578



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)

Query: 549 EPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK 593
           +P +SP ++ PI   S R +  R   CFLLT  DY  + DG IRK
Sbjct: 682 QPAMSPEDKSPITPGS-RGRYSRDRACFLLT--DYAPSPDGSIRK 723


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  293 bits (750), Expect = 3e-79
 Identities = 181/492 (36%), Positives = 251/492 (51%), Gaps = 91/492 (18%)

Query: 7   NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
           + RV LNVGG  HE    TL  LP TRL  L       DC T   D L            
Sbjct: 30  SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR------DCNTH--DSLLEV--------- 72

Query: 67  APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
                                      D+     E+FFDRHPG F  +LN+YRTG+LH  
Sbjct: 73  -------------------------CDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMM 107

Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
            ++C   F +EL +WGIDE  +E CC   Y Q ++   EE     ET     G+  D+  
Sbjct: 108 EEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTC 167

Query: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
            A KR                        ++W L E P SS AA+ +A  S+ FI++S  
Sbjct: 168 CAEKR-----------------------KKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204

Query: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
              L T      +    +   N             P L +VE VC+ WFT E+L+R + S
Sbjct: 205 ALSLNTLPELQSLDEFGQSTDN-------------PQLAHVEAVCIAWFTMEYLLRFLSS 251

Query: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
           P K +F K  LN ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL 
Sbjct: 252 PKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 311

Query: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
           RH  GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           + T+FK
Sbjct: 312 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFK 362

Query: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
           +IP  FWWA +TMTT+GYGD+YP+T  G +VG LC +AGVL IA+P+P+IVNNF  +Y  
Sbjct: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422

Query: 483 AMAKQKLPRKRK 494
              ++K  ++R+
Sbjct: 423 QKRQEKAIKRRE 434


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  290 bits (743), Expect = 2e-78
 Identities = 181/492 (36%), Positives = 253/492 (51%), Gaps = 91/492 (18%)

Query: 7   NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
           + RV +NVGG  HE    TL  LP TRL  L       DC T                  
Sbjct: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNT------------------ 69

Query: 67  APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
                       E     C        D+     E+FFDRHPG F  +LN+YRTGKLH  
Sbjct: 70  -----------HESLLEVCD-------DYNLNENEYFFDRHPGAFTSILNFYRTGKLHMM 111

Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
            ++C   F +EL +WGIDE  +E CC   Y Q ++   EE     ET     G+  D+  
Sbjct: 112 EEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTC 171

Query: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
              KR                        ++W L E P SS AA+ +A  S+ FI++S  
Sbjct: 172 CPDKR-----------------------KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208

Query: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
              L T            P +  T    Q  +  +  L +VE VC+ WFT E+L+R + S
Sbjct: 209 ALSLNTL-----------PELQETDEFGQ--LNDNRQLAHVEAVCIAWFTMEYLLRFLSS 255

Query: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
           PNK +F K  LN+ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL 
Sbjct: 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315

Query: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
           RH  GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           + T+F 
Sbjct: 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFT 366

Query: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
           +IP  FWWA +TMTT+GYGD+YP+T  G +VG LC +AGVL IA+P+P+IVNNF  +Y  
Sbjct: 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 426

Query: 483 AMAKQKLPRKRK 494
              ++K  ++R+
Sbjct: 427 QKRQEKAIKRRE 438


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  258 bits (659), Expect = 1e-68
 Identities = 156/388 (40%), Positives = 218/388 (56%), Gaps = 59/388 (15%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
              EEA++ F   +  G    ++  L  K                       Q ++W LF
Sbjct: 123 --GEEAMEKFREDE--GFIKEEERPLPEKEY---------------------QRQVWLLF 157

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--INGTSVVLQYEIE 277
           E P SS  AR IA  S+  IL+SI  FCLET       K+ T  V  I+ T+V+    I 
Sbjct: 158 EYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIF 217

Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS---- 333
           TDP    VE +C++WF+FE +VR    P+K +F KN++N ID VAI+P+++ +G      
Sbjct: 218 TDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ 276

Query: 334 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
            G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 277 EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 336

Query: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
           V++F++ +Y+AE   A+         + F +IP  FWWAVV+MTT+GYGDMYP T  G +
Sbjct: 337 VILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKI 387

Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYY 480
           VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 388 VGSLCAIAGVLTIALPVPVIVSNFNYFY 415


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  257 bits (656), Expect = 3e-68
 Identities = 163/433 (37%), Positives = 237/433 (54%), Gaps = 62/433 (14%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G K+  PA+V   +F +E++F+ +                
Sbjct: 128 EYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYEL---------------- 171

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
               EA+D F   +    DP   E L    L   D                +  + W LF
Sbjct: 172 --GSEAMDQFREDEGFIKDP---ETL----LPTND----------------IHRQFWLLF 206

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNI---VKNKTEPVINGTSVVLQYEI 276
           E P SS AAR +A  S+  +++SIT FCLET   F     +K   +P +N +  VL   +
Sbjct: 207 EYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTM 266

Query: 277 ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYL----EVGL 332
            TDP    VE  C+VWFTFE ++R V  P+K +F +N++NIID ++I+P++     E+  
Sbjct: 267 FTDPFFM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQ 325

Query: 333 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
               S      L  LR++R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 326 ETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 385

Query: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
           V++F++ +Y+AE      ++P +     F +IP GFWWAVVTMTT+GYGDM P T  G +
Sbjct: 386 VILFSSAVYFAE-----VDEPES----HFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKI 436

Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAM---AKQKLPRKRKKHIPPAPQASSPTFC 509
           VG LCA+AGVLTIA+PVPVIV+NF  +Y        KQ +P + ++ +         T  
Sbjct: 437 VGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDS 496

Query: 510 KTELNMACNSTQS 522
             + N  C++ +S
Sbjct: 497 LNKTNGGCSTEKS 509



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 15/30 (50%), Positives = 18/30 (60%)

Query: 5   ENNERVILNVGGTRHETYRSTLKTLPGTRL 34
           E N+RVI+N+ G R ET   TL   P T L
Sbjct: 83  EGNQRVIINIAGLRFETQLRTLSQFPETLL 112


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  251 bits (642), Expect = 1e-66
 Identities = 151/438 (34%), Positives = 226/438 (51%), Gaps = 46/438 (10%)

Query: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160
           E+FFDR P +F +VLN+YRTG+LHCP   C   F+EELAF+G+    V  CC   YR  +
Sbjct: 81  EYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140

Query: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFE 220
                                     A+RL  ++ A   G          L+ R+W  FE
Sbjct: 141 KEN-----------------------AERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFE 177

Query: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP 280
           +P++S AA    + + FFI VS+    +ET       +  +     G             
Sbjct: 178 NPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERF--------PQ 229

Query: 281 ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340
           A   ++  CV+ FT E+L+R+  +P++  F+++++++ID VAILP+Y+     GL     
Sbjct: 230 AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKN 284

Query: 341 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400
            DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 285 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344

Query: 401 YYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 460
           +YAE+          +  T F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L+
Sbjct: 345 FYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLS 395

Query: 461 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNST 520
           GVL IA+PVPVIV+NF   Y       K   ++K  +     A S T     L    N  
Sbjct: 396 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGT-TNAFLQYKQNGG 454

Query: 521 QSDTCLGKDNRLLEHNRS 538
             D+  G++  L   NRS
Sbjct: 455 LEDSGSGEEQALCVRNRS 472



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 3/35 (8%)

Query: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
          +E +++NV G R ET+++TL   P T   LL SSE
Sbjct: 39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSE 70


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  251 bits (642), Expect = 1e-66
 Identities = 180/494 (36%), Positives = 243/494 (49%), Gaps = 126/494 (25%)

Query: 8   ERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRA 67
           ER++LNV G R ET   TL   P T L                GD               
Sbjct: 13  ERLVLNVAGLRFETRARTLGRFPDTLL----------------GDP-------------- 42

Query: 68  PPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTG-KLHCP 126
                              +R GR  D     RE+FFDRH   F  VL YY++G +L  P
Sbjct: 43  -------------------ARRGRFYDD--ARREYFFDRHRPSFDAVLYYYQSGGRLRRP 81

Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLA 186
           A V   +F EE+AF+G+                                          A
Sbjct: 82  AHVPLDVFLEEVAFYGLG-----------------------------------------A 100

Query: 187 AKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTF 246
           A    + +  G   P  +    R    ++W LFE P SS+AAR +A  S+  ILVSI  F
Sbjct: 101 AALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVF 160

Query: 247 CLETHEAFNIVKNKT-----------EPVINGTSVVLQY--EIETDPALTYVEGVCVVWF 293
           CLET   F   ++ T              +NG+S +      +  +     VE +C+ WF
Sbjct: 161 CLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWF 220

Query: 294 TFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS-----GLSSKAAKDVLGFLR 348
           +FE LVR++  P+K  F KN++N+IDFVAILP+++ +G       G+  +A    L  LR
Sbjct: 221 SFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMS--LAILR 278

Query: 349 VVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAE--RV 406
           V+R VR+ RIFKL+RH  GL++LG TLRAS  E  LLI FL +GV++F++ +Y+AE  RV
Sbjct: 279 VIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRV 338

Query: 407 GAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIA 466
            +            F +IP  FWWAVVTMTT+GYGDM P T  G +VG+LCA+AGVLTI+
Sbjct: 339 DSH-----------FTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTIS 387

Query: 467 MPVPVIVNNFGMYY 480
           +PVPVIV+NF  +Y
Sbjct: 388 LPVPVIVSNFSYFY 401


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  251 bits (641), Expect = 1e-66
 Identities = 163/489 (33%), Positives = 234/489 (47%), Gaps = 90/489 (18%)

Query: 10  VILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPP 69
           +++NVGG R   Y   L   P TRLA L +                              
Sbjct: 25  IVVNVGGVRQVLYGDLLSQYPETRLAELIN------------------------------ 54

Query: 70  LSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADV 129
                  C  GG     S      D+  G REF+FDR P  F  V+  Y  G++H    +
Sbjct: 55  -------CLAGGYDTIFSL---CDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104

Query: 130 CGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKR 189
           C   F+ E+ FW +D   ++ CC     + R  EE  +I     LI  D           
Sbjct: 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKR--EELEEIARRVQLILDD----------- 151

Query: 190 LGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLE 249
           LG+         D   GRWRR Q  +W   E P SS  AR +A  S   ILVS    C+ 
Sbjct: 152 LGV---------DAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMG 202

Query: 250 THEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLE 309
           T     ++  +   V +             P L  VE  C+ WFT E+L+R+  SPNKL 
Sbjct: 203 TIPELQVLDAEGNRVEH-------------PTLENVETACIGWFTLEYLLRLFSSPNKLH 249

Query: 310 FIKNLLNIIDFVAILPFYLEVGLSGLSSKAAK--DVLGFLRVVRFVRILRIFKLTRHFVG 367
           F  + +NI+D +AILPFY+ + L+ L ++  +  +V   ++ +R +RI RIFKL RH  G
Sbjct: 250 FALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSG 309

Query: 368 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIG 427
           L+ L + L+ S  E  LL+++LA+G+ +F+ + Y  E+         +   T FK+IP  
Sbjct: 310 LQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQ---------SHPETLFKSIPQS 360

Query: 428 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQ 487
           FWWA++TMTT+GYGD+YP+T  G L  A+  L GV+ IA+P+  I+NNF  YY+    KQ
Sbjct: 361 FWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN----KQ 416

Query: 488 KLPRKRKKH 496
           ++     KH
Sbjct: 417 RVLETAAKH 425


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  249 bits (636), Expect = 5e-66
 Identities = 176/548 (32%), Positives = 276/548 (50%), Gaps = 73/548 (13%)

Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--R 157
           +E+FFDR P VF  VLN+YRTGKLH P   C   +++ELAF+GI    +  CC+  Y  R
Sbjct: 80  KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDR 139

Query: 158 QHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
           +  +AE  +D              D D    +  +   +               +  MW 
Sbjct: 140 KRENAERLMD--------------DNDSENNQESMPSLS--------------FRQTMWR 171

Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
            FE+P++S  A    + + FFI VS+ T  +ET     +  +K  P     SV       
Sbjct: 172 AFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV------- 224

Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
              A   ++  CV+ FT E+L+R+  +P++  FI+++++IID VAI+P+Y+     GL  
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVM 276

Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 277 TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 336

Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 337 TVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 387

Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   SS  +  ++ N
Sbjct: 388 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRN 447

Query: 515 MACN------STQSDTCLGKDNRLLE--HNRSVLSGDDSTGSEPPLSPPERLPIRRSSTR 566
              N       T  +  +GK   L+E  H+  +   + +TG    +  P  L +R S+ +
Sbjct: 448 GLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDP-LLSVRTSTIK 506

Query: 567 DKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGN--ALRLSPVTSPYNSP 624
           +     E  F     +  C           +S SL++  GL     + R    T   NS 
Sbjct: 507 NHEFIDEQMF-----EQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSN 561

Query: 625 CPLRRSRS 632
            P  R RS
Sbjct: 562 LPATRLRS 569



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/35 (45%), Positives = 24/35 (68%), Gaps = 3/35 (8%)

Query: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
          +E ++LNV G R +T+R+TL+  P T   LL S+E
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDT---LLGSTE 70


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  247 bits (630), Expect = 3e-65
 Identities = 159/400 (39%), Positives = 223/400 (55%), Gaps = 70/400 (17%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 218 EYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQL---------------- 261

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
              EEAL  F   +   G   ++ED A                         + ++W LF
Sbjct: 262 --GEEALLKFREDE---GFVREEEDRALPE-------------------NEFKKQIWLLF 297

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--------INGTSVV 271
           E P SS  AR IA  S+  IL+SI  FCLET   F   ++    +        +N TS  
Sbjct: 298 EYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAP 357

Query: 272 ----LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY 327
                 + I  DP    VE VC+VWF+FEF+VR    P++  F KN++NIID V+ILP++
Sbjct: 358 HLENSGHTIFNDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYF 416

Query: 328 LEVGLS-----GLSSKAAKDVLGF--LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 380
           + +G       G  +   +  + F  LR++R VR+ RIFKL+RH  GL++LGHTLRAS  
Sbjct: 417 ITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMR 476

Query: 381 EFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGY 440
           E  LLI FL +GV++F++ +Y+AE      ++P+    T F++IP  FWWAVVTMTT+GY
Sbjct: 477 ELGLLIFFLFIGVILFSSAVYFAEA-----DEPT----THFQSIPDAFWWAVVTMTTVGY 527

Query: 441 GDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           GDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 528 GDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  246 bits (628), Expect = 5e-65
 Identities = 157/399 (39%), Positives = 223/399 (55%), Gaps = 75/399 (18%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 75  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------------- 118

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
              EEA+++F           +DE         E+   L  P+ +       Q ++W LF
Sbjct: 119 --GEEAMEMFR----------EDEGYIK-----EEERPL--PENE------FQRQVWLLF 153

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV----------INGTS 269
           E P SS  AR IA  S+  IL+SI +FCLET   F   +++ E +           N T 
Sbjct: 154 EYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSGVTFHTYSNSTI 210

Query: 270 VVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLE 329
              Q    TDP    VE +C++WF+FEFLVR    P+K  F  N++NIID VAI+P+++ 
Sbjct: 211 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT 269

Query: 330 VGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 381
           +G     ++  +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E
Sbjct: 270 LGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 327

Query: 382 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYG 441
             LLI FL +GV++F++ +Y+AE         +    +QF +IP  FWWAVV+MTT+GYG
Sbjct: 328 LGLLIFFLFIGVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYG 378

Query: 442 DMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           DM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  246 bits (627), Expect = 6e-65
 Identities = 154/480 (32%), Positives = 235/480 (48%), Gaps = 82/480 (17%)

Query: 5   ENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPP 64
           ++ E V LNVGG +    +STL   P TRL  L +       L                 
Sbjct: 12  QDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELC-------------- 57

Query: 65  PRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLH 124
                                        D+    +E++FDR+P +F YVLN+Y TGKLH
Sbjct: 58  ----------------------------DDYSVADKEYYFDRNPSLFRYVLNFYYTGKLH 89

Query: 125 CPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDED 184
              ++C   F +E+ +WGI+E  ++ CC   Y++ ++     D  +    +  D   +E 
Sbjct: 90  VMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEES 149

Query: 185 -LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSI 243
            L  K L   D    G          +L+ ++W   E+P    +A+ IA +SL  +L SI
Sbjct: 150 SLFEKELEKFDTLRFG----------QLRKKIWIRMENPAYCLSAKLIAISSLSVVLASI 199

Query: 244 TTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVF 303
              C+ +   F     + +                DP L  VE  C+ WFT E  VR+  
Sbjct: 200 VAMCVHSMSEFQNEDGEVD----------------DPVLEGVEIACIAWFTGELAVRLAA 243

Query: 304 SPNKLEFIKNLLNIIDFVAILPFY--LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKL 361
           +P + +F KN LNIIDFV+I+PFY  L V      S+  +++   ++++R +RI RI KL
Sbjct: 244 APCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKL 303

Query: 362 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ- 420
            RH VGLR LG TLR S +E  LL++FL++G+ IF+ +IY  E+           +HT  
Sbjct: 304 ARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK----------DDHTSS 353

Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
             +IPI +WWA ++MTT+GYGD +P T +G L+ + C + G+L +A+P+ +I N F  YY
Sbjct: 354 LTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  245 bits (626), Expect = 8e-65
 Identities = 155/394 (39%), Positives = 215/394 (54%), Gaps = 66/394 (16%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G ++  P +V   +F EE+ F+ +                
Sbjct: 146 EYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQL---------------- 189

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
              EEA++ F                       ED   L   +    R R  Q ++W LF
Sbjct: 190 --GEEAMEKFR----------------------EDEGFLREEERPLPR-RDFQRQVWLLF 224

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKN--------KTEPVINGTSVV 271
           E P SS  AR IA  S+  IL+SI  FCLET   F   K+          E   N TS  
Sbjct: 225 EYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGS 284

Query: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
                        VE +C++WF+FE LVR    P+K  F +N++N+ID VAI+P+++ +G
Sbjct: 285 RAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLG 344

Query: 332 LS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 386
                  G   +A    L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI
Sbjct: 345 TELAERQGNGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLI 402

Query: 387 IFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQ 446
            FL +GV++F++ +Y+AE      +DP++     F +IP  FWWAVVTMTT+GYGDM+P 
Sbjct: 403 FFLFIGVILFSSAVYFAEA-----DDPTSG----FSSIPDAFWWAVVTMTTVGYGDMHPV 453

Query: 447 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 454 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  245 bits (625), Expect = 1e-64
 Identities = 153/446 (34%), Positives = 239/446 (53%), Gaps = 63/446 (14%)

Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--R 157
           +E+FFDR P VF  VLN+YRTGKLH P   C   +++ELAF+GI    +  CC+  Y  R
Sbjct: 80  KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDR 139

Query: 158 QHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
           +  +AE  +D              D D    +  +   +               +  MW 
Sbjct: 140 KRENAERLMD--------------DNDSENNQESMPSLS--------------FRQTMWR 171

Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
            FE+P++S  A    + + FFI VS+ T  +ET     +  +K  P     SV       
Sbjct: 172 AFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV------- 224

Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
              A   ++  CV+ FT E+L+R+  +P++  FI+++++IID VAI+P+Y+     GL  
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVM 276

Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 277 TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 336

Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 337 TVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 387

Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   SS  +  ++ N
Sbjct: 388 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRN 447

Query: 515 MACN------STQSDTCLGKDNRLLE 534
              N       T  +  +GK   L+E
Sbjct: 448 GLLNEALELTGTPEEEHMGKTTSLIE 473



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/35 (45%), Positives = 24/35 (68%), Gaps = 3/35 (8%)

Query: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
          +E ++LNV G R +T+R+TL+  P T   LL S+E
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDT---LLGSTE 70


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  242 bits (617), Expect = 9e-64
 Identities = 161/435 (37%), Positives = 222/435 (51%), Gaps = 107/435 (24%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 83  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------------- 127

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL--GGPDGKSGRWRRLQPRMWA 217
                                 DE LAA R   ED   L  GG D K    +  Q ++W 
Sbjct: 128 ----------------------DEALAAFR---EDEGCLPEGGEDEKPLPSQPFQRQVWL 162

Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--------NKTEPVINGTS 269
           LFE P SS  AR IA  S+  IL+SI  FCLET   F +          ++  PV  G+ 
Sbjct: 163 LFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQ 222

Query: 270 VVLQYEIETDPALTY-------------------------------VEGVCVVWFTFEFL 298
              + E + D + T+                               VE +C+VWFTFE L
Sbjct: 223 ---EEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279

Query: 299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG------------- 345
           VR    P+K  F +N++NIID VAI P+++ +G   +  +  +   G             
Sbjct: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339

Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
            LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE 
Sbjct: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE- 398

Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
                   +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTI
Sbjct: 399 --------ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTI 450

Query: 466 AMPVPVIVNNFGMYY 480
           A+PVPVIV+NF  +Y
Sbjct: 451 ALPVPVIVSNFNYFY 465


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  241 bits (614), Expect = 2e-63
 Identities = 146/429 (34%), Positives = 235/429 (54%), Gaps = 56/429 (13%)

Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           +++FFDR P +F ++LN+YRTGKLH P   C   ++EELAF+G+    +  CC+  Y+  
Sbjct: 81  QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140

Query: 160 R--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
           R  +AE   D  +T                      D AG       + R      R+W 
Sbjct: 141 RRENAERLQDDADT----------------------DTAGESALPTMTAR-----QRVWR 173

Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
            FE+P++S  A    + + FFI VS+    +ET    +   +  E        V  + ++
Sbjct: 174 AFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLD 233

Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
           T          CV+ FT E+L+R+  +P++  F++++++IID VAILP+Y+     GL  
Sbjct: 234 T---------ACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279

Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
              +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFA
Sbjct: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339

Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
           T+++YAE+          S  ++F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390

Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
           +L+GVL IA+PVPVIV+NF  +Y+    A ++  +K+ +   I  A   S+  + +++ N
Sbjct: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450

Query: 515 -MACNSTQS 522
            +  N  QS
Sbjct: 451 GLLSNQLQS 459



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 3/32 (9%)

Query: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
          ++LNV GTR +T++ TL+  P T   LL SSE
Sbjct: 43 IVLNVSGTRFQTWQDTLERYPDT---LLGSSE 71


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  238 bits (607), Expect = 1e-62
 Identities = 156/413 (37%), Positives = 217/413 (52%), Gaps = 84/413 (20%)

Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
           E+FFDR+   F  +L YY++G +L  P +V   +F +E+ F+ +                
Sbjct: 162 EYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQL---------------- 205

Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
              +EA++ F           +DE             G    + K       Q ++W +F
Sbjct: 206 --GDEAMERFR----------EDE-------------GFIKEEEKPLPRNEFQRQVWLIF 240

Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE------------PVING 267
           E P SS +AR IA  S+  IL+SI TFCLET   F   +                P  NG
Sbjct: 241 EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG 300

Query: 268 TSVVLQYEIETDPALT---------YVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNII 318
           + V+      T   L           VE  CV+WFTFE LVR    P+K  F +N++NII
Sbjct: 301 SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII 360

Query: 319 DFVAILPFYLEVGLS-----------GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVG 367
           D VAI P+++ +G             G + + A   L  LRV+R VR+ RIFKL+RH  G
Sbjct: 361 DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMS-LAILRVIRLVRVFRIFKLSRHSKG 419

Query: 368 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIG 427
           L++LG TL+AS  E  LLI FL +GV++F++ +Y+AE         + ++ T F +IP  
Sbjct: 420 LQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---------ADNQGTHFSSIPDA 470

Query: 428 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           FWWAVVTMTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 471 FWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 523


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  229 bits (585), Expect = 4e-60
 Identities = 153/491 (31%), Positives = 238/491 (48%), Gaps = 92/491 (18%)

Query: 12  LNVGGTRHETYRSTLKTLPGTRLALLA----SSEPPGDCLTTAGDKLQPSPPPLSPPPRA 67
           +NVGG+R    +  L   P TRL  LA    S   PG         L   P PL     A
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPG--------ALAAVPSPLELCDDA 94

Query: 68  PPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPA 127
            P+                              E+FFDR    F YVL+YYRTG+LH   
Sbjct: 95  NPVD----------------------------NEYFFDRSSQAFRYVLHYYRTGRLHVME 126

Query: 128 DVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAA 187
            +C   F +E+ +WGIDE  ++ CC   Y + ++  E LD  +          D ED  +
Sbjct: 127 QLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKK----------DTEDQES 176

Query: 188 KRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFC 247
           +    +D +         G    ++ ++W + E P SS AAR     S+ F++VSI    
Sbjct: 177 QHESEQDFS--------QGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMA 228

Query: 248 LETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNK 307
           L + E               + + LQ        L  +E VC+ WFT EF++R +   ++
Sbjct: 229 LMSAEL--------------SWLDLQ-------LLEILEYVCISWFTGEFVLRFLCVRDR 267

Query: 308 LEFIKNLLNIIDFVAILPFYLEVGLSGLS----SKAAKDVLGFLRVVRFVRILRIFKLTR 363
             F++ + NIID +AILPFY+ + +  LS    ++  ++V   ++V+R +R LR+ KL R
Sbjct: 268 CRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGR 327

Query: 364 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKN 423
           H  GLR LG T+     E  LL++FL++G+ IF+T+ Y+AE+         +   T F +
Sbjct: 328 HSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQ---------SIPDTTFTS 378

Query: 424 IPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLA 483
           +P  +WWA  +MTT+GYGD+ P T +G +V  +C L+G+L +A+P+ +I + F   Y   
Sbjct: 379 VPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTL 438

Query: 484 MAKQKLPRKRK 494
             K+   R+R+
Sbjct: 439 KLKEAAVRQRE 449


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  229 bits (585), Expect = 4e-60
 Identities = 137/389 (35%), Positives = 205/389 (52%), Gaps = 34/389 (8%)

Query: 94  DHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCW 153
           D+    REF+FDR+P +F YVL++Y TGKLH  A++C   F +E+ +WGI+E  ++ CC 
Sbjct: 61  DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120

Query: 154 MTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQP 213
            +Y   +   E     E  D        DE LA       DA+   G     G +RR   
Sbjct: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAF----YNDASKFDGQ--PLGNFRR--- 171

Query: 214 RMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQ 273
           ++W   ++P  S  +R  +  S+  ++ SI T CL +   F I  ++  P          
Sbjct: 172 QLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNP---------- 221

Query: 274 YEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY--LEVG 331
                DP    VE   + WFTFE + R   +P+ L+F KN LN+ID ++I+PFY  L V 
Sbjct: 222 ---GEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278

Query: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
           L   S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++
Sbjct: 279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSV 338

Query: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
           G+ IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G 
Sbjct: 339 GISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGK 388

Query: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYY 480
           L  + C LAG+L + +P+ +I N F  +Y
Sbjct: 389 LTASACILAGILVVVLPITLIFNKFSHFY 417


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  223 bits (567), Expect = 5e-58
 Identities = 148/483 (30%), Positives = 225/483 (46%), Gaps = 74/483 (15%)

Query: 6   NNERVILNVGGTRHETYRSTLKTLPGTRLALL--ASSEPPGDCLTTAGDKLQPSPPPLSP 63
           ++E + +NVGG R +     L   PGTRL  L  A+SE     L                
Sbjct: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRL---------------- 91

Query: 64  PPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKL 123
                                         D+    REF+FDRHPG F  +L++YRTG L
Sbjct: 92  ----------------------------CDDYDEAAREFYFDRHPGFFLSLLHFYRTGHL 123

Query: 124 HCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL--DIFETPDLIGGDPGD 181
           H   ++C   F +E  +WG+ E  +  CC   Y + R  +     +  +TP  +  DP  
Sbjct: 124 HVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSV--DPCP 181

Query: 182 DEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILV 241
           DE    +R    + A  G     + R  RL+ R+W   E+P  S  ++  +  S+  +L 
Sbjct: 182 DEISDVQR----ELARYG-----AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLA 232

Query: 242 SITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI 301
           SI   C+ +   +   +     V    +      +  DP L  +E  C+ WF+FE   R+
Sbjct: 233 SIAAMCIHSLPEYQ-AREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291

Query: 302 VFSPNKLEFIKNLLNIIDFVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILR 357
           + +P+   F  + LN+ID V++LPFYL     V L     K    +   ++V R +RI R
Sbjct: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFR 351

Query: 358 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASE 417
           + KL RH  GLR LG TL+ S  E  +L+++LA+GV +F+ + Y AE+           E
Sbjct: 352 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK----------EE 401

Query: 418 HTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 477
              F  IP  +WW  V+MTT+GYGD+ P T +G L  + C L G+L +A+P+ +I N F 
Sbjct: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461

Query: 478 MYY 480
            +Y
Sbjct: 462 HFY 464


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  217 bits (553), Expect = 2e-56
 Identities = 145/486 (29%), Positives = 223/486 (45%), Gaps = 88/486 (18%)

Query: 5   ENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPP 64
           +   R+I+NVGG ++    +TL   P TRL  L +     D L                 
Sbjct: 60  DRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVC-------------- 105

Query: 65  PRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLH 124
                                        D+     EFFFDR+PG F  +L + R GKL 
Sbjct: 106 ----------------------------DDYDVTCNEFFFDRNPGAFGTILTFLRAGKLR 137

Query: 125 CPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH-RDAEEALDIFETPDLIGGDPGDDE 183
              ++C   F+EEL +WGI E  ++ CC   Y Q   +  E ++  E  D +  +  D E
Sbjct: 138 LLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSE 197

Query: 184 DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSI 243
                           GP    GR  R   R+  + E P+S    +  A  S+ F+ V+ 
Sbjct: 198 ----------------GPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTA 241

Query: 244 TTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVF 303
               + T      + +  E    G    + + +        VE VCV WF+ EFL+R++ 
Sbjct: 242 VNLSVST------LPSLREEEEQGHCSQMCHNV------FIVESVCVGWFSLEFLLRLIQ 289

Query: 304 SPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG---------FLRVVRFVR 354
           +P+K  F+++ L +ID VAILP+Y+ + + G ++   K   G          LRV+R +R
Sbjct: 290 APSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALR 349

Query: 355 ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPS 414
           IL + +L RH +GL+ LG T R  T EF LL++FL + + +FA ++Y  E          
Sbjct: 350 ILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIEN--------E 401

Query: 415 ASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN 474
            ++  +F +IP  +WWAV+TMTT+GYGDM P++  G +V     L+G+L +A PV  I +
Sbjct: 402 MADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFH 461

Query: 475 NFGMYY 480
            F   Y
Sbjct: 462 TFSRSY 467


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  209 bits (533), Expect = 5e-54
 Identities = 130/396 (32%), Positives = 202/396 (51%), Gaps = 51/396 (12%)

Query: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160
           EFFFDR P  F  ++   R GKL      C   F +ELA+WGIDE  +E CC    R+  
Sbjct: 68  EFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRR- 126

Query: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPD---GKSGRWRRLQPRMWA 217
                                +E+ A  R G  +    G P    G  GR +R + R+  
Sbjct: 127 ---------------------EEEAAEARAGPTERGAQGSPARALGPRGRLQRGRRRLRD 165

Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
           + ++P+S  A +  A  S+ F+ V+    CL T       + + E      S+ +     
Sbjct: 166 VVDNPHSGLAGKLFACVSVSFVAVTAVGLCLSTMPDIRAEEERGECSPKCRSLFV----- 220

Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
                  +E VCV WF+FEFL+R + + +K  F++  LNIID +A+LPFY+ + L   + 
Sbjct: 221 -------LETVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAG 273

Query: 338 KAAKDVLG----FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV 393
                +L      LR++R +R+L + +L RH +GLR LG T+R    EF LL++FL + +
Sbjct: 274 PGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAM 333

Query: 394 LIFATMIYYAER-VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
            +FA +++ AER +GA+ +         F ++P  +WWAV++MTT+GYGDM P++  G +
Sbjct: 334 ALFAPLVHLAERELGARRD---------FSSVPASYWWAVISMTTVGYGDMVPRSLPGQV 384

Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 488
           V     L+G+L +A PV  I + F   YS    +Q+
Sbjct: 385 VALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ 420


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,517,959
Number of Sequences: 37866
Number of extensions: 1600011
Number of successful extensions: 15808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 223
Number of HSP's that attempted gapping in prelim test: 12430
Number of HSP's gapped (non-prelim): 2601
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.