Guide to the Human Genome
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Search of human proteins with 21071067

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21071067 TBP-associated factor 5 [Homo sapiens]
         (800 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21071067 TBP-associated factor 5 [Homo sapiens]                   1619   0.0  
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    372   e-103
gi|16554629 WD repeat domain 5 [Homo sapiens]                         146   8e-35
gi|16554627 WD repeat domain 5 [Homo sapiens]                         146   8e-35
gi|23199987 WD repeat domain 5B [Homo sapiens]                        144   2e-34
gi|113865883 WD repeat domain 38 [Homo sapiens]                       137   3e-32
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    137   4e-32
gi|26665869 WD repeat domain 51B [Homo sapiens]                       136   7e-32
gi|32189425 WD repeat domain 69 [Homo sapiens]                        135   1e-31
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            126   7e-29
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            126   7e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            126   7e-29
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   123   6e-28
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   118   2e-26
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   118   2e-26
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   118   2e-26
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...   117   4e-26
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...   117   4e-26
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    116   7e-26
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    116   7e-26
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    116   7e-26
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      115   2e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   114   4e-25
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...   114   4e-25
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         112   1e-24
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         112   1e-24
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         112   1e-24
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           112   1e-24
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...   112   1e-24
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   112   2e-24

>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 1619 bits (4192), Expect = 0.0
 Identities = 800/800 (100%), Positives = 800/800 (100%)

Query: 1   MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD 60
           MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD
Sbjct: 1   MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD 60

Query: 61  GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA 120
           GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA
Sbjct: 61  GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA 120

Query: 121 GLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG 180
           GLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG
Sbjct: 121 GLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG 180

Query: 181 PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF 240
           PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF
Sbjct: 181 PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF 240

Query: 241 YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDF 300
           YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDF
Sbjct: 241 YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDF 300

Query: 301 RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA 360
           RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA
Sbjct: 301 RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA 360

Query: 361 GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN 420
           GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN
Sbjct: 361 GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN 420

Query: 421 APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD 480
           APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD
Sbjct: 421 APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD 480

Query: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540
           DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
           VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
           CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720

Query: 721 RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV 780
           RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV
Sbjct: 721 RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV 780

Query: 781 VHLHFTRRNLVLAAGAYSPQ 800
           VHLHFTRRNLVLAAGAYSPQ
Sbjct: 781 VHLHFTRRNLVLAAGAYSPQ 800


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  372 bits (956), Expect = e-103
 Identities = 228/632 (36%), Positives = 330/632 (52%), Gaps = 80/632 (12%)

Query: 169 SGATVVSGSASGPAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECS 228
           S   +  G      A     ++ V+ +   + ++SA   Q +P  YE  +  L++F+  S
Sbjct: 25  SDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQAEPQQYEVQFGRLRNFLTDS 84

Query: 229 LDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKK 288
              H  E+  L YPLFV+++L LV N  ++  +SF+ +FHG            L + ++K
Sbjct: 85  DSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFYSRFHG----------MFLQNASQK 134

Query: 289 ---EHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGM 345
              E ++  +T+ D   S F LR   D+  +++  LQE   N +   +Q           
Sbjct: 135 DVIEQLQTTQTIQDI-LSNFKLRAFLDNKYVVR--LQEDSYNYLIRYLQSD--------- 182

Query: 346 PRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKP 405
                                 N +     L K   + + LD +           K+   
Sbjct: 183 ----------------------NNT----ALCKVLTLHIHLDVQPA---------KRTDY 207

Query: 406 KKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYT 465
           +  + GS S+ ++    P + +P P L++   L+ +   +E+ KRV+ GP  L +ICFY 
Sbjct: 208 QLYASGSSSRSENNGLEPPD-MPSPILQNEAALEVL---QESIKRVKDGPPSLTTICFYA 263

Query: 466 FLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLE 525
           F N  Q L   +++ DS L+A GF +S +++WS+  KKL+S     D+S I    D +LE
Sbjct: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD-ILE 322

Query: 526 RIMDE--KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG 583
              DE     +E+KIL GH GPVY   F  D + LLS SED ++R W L +FT  V Y+G
Sbjct: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQG 382

Query: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
           H YPVWD   SPY  YF SG HDR ARLW+ D   PLRI+AGHLADV+C +FHPNSNY+A
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           TGS D+TVRLW    GN VR+FTGH+GP+ SL FSPNG++LA+   D R+ LWD+  G +
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPE 763
             EL+GHTD + SL FS D  ++AS SMDN+VR+WD    +     D             
Sbjct: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPAD------------- 549

Query: 764 NSQELLLGTYMTKSTPVVHLHFTRRNLVLAAG 795
            S   L+G Y  + + V+ + F   NL+L  G
Sbjct: 550 GSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  146 bits (368), Expect = 8e-35
 Identities = 86/292 (29%), Positives = 147/292 (50%), Gaps = 17/292 (5%)

Query: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASD 512
           +T     + +++V  + +   +A   AD  +++W     K           +  V  +SD
Sbjct: 39  FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98

Query: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
            +L+   SDD   +I D  +   LK L GHS  V+  +F+P  N ++S S D +VR+W +
Sbjct: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 631
           +T  CL     H+ PV    F+  G   VS  +D + R+W T   Q L+ +       V+
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218

Query: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGA 688
             +F PN  Y+   + D T++LWD   G C++ +TGHK   + +   FS   G+++ +G+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278

Query: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738
            D  V +W++    +V +L+GHTD V S        I+AS +++N  T++LW
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  122 bits (305), Expect = 2e-27
 Identities = 66/223 (29%), Positives = 106/223 (47%), Gaps = 7/223 (3%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+  V    FSP+  +L SSS D  +++W            GH   + D  +S    
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
             VS   D+  ++W     + L+   GH   V C  F+P SN + +GS D +VR+WDV  
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 717
           G C++    H  P+ ++ F+ +G  + + + DG   +WD   G  +  L       V  +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220

Query: 718 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760
           +FS +G+ + + ++DNT++LWD  K           T TGH N
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257



 Score =  115 bits (289), Expect = 1e-25
 Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 4/242 (1%)

Query: 502 KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS 561
           K + SVK + +   +   S D L +I         K + GH   +   ++S D N L+S+
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621
           S+D T+++W + +  CL   KGH+  V+   F+P     VSG  D   R+W     + L+
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPN 680
               H   V+   F+ + + + + S D   R+WD  +G C++ +      P+  + FSPN
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRL 737
           G+++     D  + LWD   G  +    GH +    +   FS   G+ + SGS DN V +
Sbjct: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285

Query: 738 WD 739
           W+
Sbjct: 286 WN 287



 Score =  109 bits (272), Expect = 1e-23
 Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%)

Query: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
           GH   V   +FSP G +  S   D++ ++W     +  +  +GH   ++   +  +SN +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702
            + S D+T+++WDV +G C++   GH   +    F+P    + +G+ D  V +WD+  G 
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760
            +  L  H+D V ++ F+RDG ++ S S D   R+WD     + L+T  DD       + 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221

Query: 761 LPENSQELLLGT 772
              N + +L  T
Sbjct: 222 FSPNGKYILAAT 233



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 24/174 (13%)

Query: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
           AGH   V+  +F PN  ++A+ SAD+ +++W   +G   +  +GHK  I  + +S +   
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743
           L + + D  + +WD+  G  +  LKGH++ V    F+    ++ SGS D +VR+WD +K 
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKT 160

Query: 744 FEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797
            + L+T           LP +S             PV  +HF R   ++ + +Y
Sbjct: 161 GKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 50/198 (25%), Positives = 79/198 (39%), Gaps = 35/198 (17%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C  T       ++AV    D SLI     D   R+W                   D  S 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-------------------DTASG 203

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
             L+ ++D+            + PV    FSP+  Y+L+++ D T++LW      CL  Y
Sbjct: 204 QCLKTLIDD-----------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252

Query: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
            GH    Y ++       G + VSG  D +  +W     + ++   GH   V  T  HP 
Sbjct: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 639 SNYVATGSA--DRTVRLW 654
            N +A+ +   D+T++LW
Sbjct: 313 ENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  146 bits (368), Expect = 8e-35
 Identities = 86/292 (29%), Positives = 147/292 (50%), Gaps = 17/292 (5%)

Query: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASD 512
           +T     + +++V  + +   +A   AD  +++W     K           +  V  +SD
Sbjct: 39  FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98

Query: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
            +L+   SDD   +I D  +   LK L GHS  V+  +F+P  N ++S S D +VR+W +
Sbjct: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 631
           +T  CL     H+ PV    F+  G   VS  +D + R+W T   Q L+ +       V+
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218

Query: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGA 688
             +F PN  Y+   + D T++LWD   G C++ +TGHK   + +   FS   G+++ +G+
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278

Query: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738
            D  V +W++    +V +L+GHTD V S        I+AS +++N  T++LW
Sbjct: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  122 bits (305), Expect = 2e-27
 Identities = 66/223 (29%), Positives = 106/223 (47%), Gaps = 7/223 (3%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+  V    FSP+  +L SSS D  +++W            GH   + D  +S    
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
             VS   D+  ++W     + L+   GH   V C  F+P SN + +GS D +VR+WDV  
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 717
           G C++    H  P+ ++ F+ +G  + + + DG   +WD   G  +  L       V  +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220

Query: 718 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760
           +FS +G+ + + ++DNT++LWD  K           T TGH N
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257



 Score =  115 bits (289), Expect = 1e-25
 Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 4/242 (1%)

Query: 502 KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS 561
           K + SVK + +   +   S D L +I         K + GH   +   ++S D N L+S+
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621
           S+D T+++W + +  CL   KGH+  V+   F+P     VSG  D   R+W     + L+
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPN 680
               H   V+   F+ + + + + S D   R+WD  +G C++ +      P+  + FSPN
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRL 737
           G+++     D  + LWD   G  +    GH +    +   FS   G+ + SGS DN V +
Sbjct: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285

Query: 738 WD 739
           W+
Sbjct: 286 WN 287



 Score =  109 bits (272), Expect = 1e-23
 Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%)

Query: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
           GH   V   +FSP G +  S   D++ ++W     +  +  +GH   ++   +  +SN +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702
            + S D+T+++WDV +G C++   GH   +    F+P    + +G+ D  V +WD+  G 
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760
            +  L  H+D V ++ F+RDG ++ S S D   R+WD     + L+T  DD       + 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221

Query: 761 LPENSQELLLGT 772
              N + +L  T
Sbjct: 222 FSPNGKYILAAT 233



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 24/174 (13%)

Query: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
           AGH   V+  +F PN  ++A+ SAD+ +++W   +G   +  +GHK  I  + +S +   
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743
           L + + D  + +WD+  G  +  LKGH++ V    F+    ++ SGS D +VR+WD +K 
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKT 160

Query: 744 FEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797
            + L+T           LP +S             PV  +HF R   ++ + +Y
Sbjct: 161 GKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 50/198 (25%), Positives = 79/198 (39%), Gaps = 35/198 (17%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C  T       ++AV    D SLI     D   R+W                   D  S 
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-------------------DTASG 203

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
             L+ ++D+            + PV    FSP+  Y+L+++ D T++LW      CL  Y
Sbjct: 204 QCLKTLIDD-----------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252

Query: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
            GH    Y ++       G + VSG  D +  +W     + ++   GH   V  T  HP 
Sbjct: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 639 SNYVATGSA--DRTVRLW 654
            N +A+ +   D+T++LW
Sbjct: 313 ENIIASAALENDKTIKLW 330


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  144 bits (364), Expect = 2e-34
 Identities = 85/291 (29%), Positives = 147/291 (50%), Gaps = 17/291 (5%)

Query: 465 TFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDL 513
           T +   + +++V  + +   +A   AD  + +W     K           +  V  +SD 
Sbjct: 36  TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95

Query: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
           S +   SDD   ++ D ++   LK L GHS  V+  +F+P  N ++S S D TV++W ++
Sbjct: 96  SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155

Query: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNC 632
           T  CL     H+ PV    F+  G   VSG +D + R+W     Q L+ +       V+ 
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGAT 689
            +F PN  Y+ T + D T++LWD   G C++ +TGHK   + +   FS   G+++ +G+ 
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275

Query: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738
           D  V +W++    +V +L+GHTD V S        ++AS +++N  T++LW
Sbjct: 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score =  119 bits (299), Expect = 8e-27
 Identities = 69/238 (28%), Positives = 118/238 (49%), Gaps = 4/238 (1%)

Query: 506 SVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG 565
           SVK + +   +   S D L  I         K LYGH+  +   ++S D + L+S+S+D 
Sbjct: 46  SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105

Query: 566 TVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAG 625
           T++LW +++  CL   KGH+  V+   F+P     +SG  D   ++W     + L+  + 
Sbjct: 106 TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165

Query: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFL 684
           H   V+   F+ + + + +GS D   R+WD  +G C++ +      P+  + FSPNG+++
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225

Query: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRLWD 739
            T   D  + LWD   G  +    GH +    +   FS   G+ + SGS DN V +W+
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283



 Score =  103 bits (256), Expect = 8e-22
 Identities = 53/192 (27%), Positives = 94/192 (48%), Gaps = 3/192 (1%)

Query: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
           GH   V   +FSP G +  S   DR+  +W     +  +   GH  +++   +  +S+ +
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702
            + S D+T++LWDV +G C++   GH   +    F+P    + +G+ D  V +W++  G 
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158

Query: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760
            +  L  H+D V ++ F+  G ++ SGS D   R+WDA    + L+T  DD       + 
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG-QCLKTLVDDDNPPVSFVK 217

Query: 761 LPENSQELLLGT 772
              N + +L  T
Sbjct: 218 FSPNGKYILTAT 229



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 49/198 (24%), Positives = 78/198 (39%), Gaps = 35/198 (17%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C  T       ++AV      SLI  G  D   R+W                   D  S 
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW-------------------DAASG 199

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
             L+ ++D+            + PV    FSP+  Y+L+++ D T++LW      CL  Y
Sbjct: 200 QCLKTLVDD-----------DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248

Query: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
            GH    Y ++       G + VSG  D +  +W     + ++   GH   V     HP 
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308

Query: 639 SNYVATGSA--DRTVRLW 654
            N +A+ +   D+T++LW
Sbjct: 309 ENLIASAALENDKTIKLW 326



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 17/34 (50%), Positives = 23/34 (67%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
           L GHT+ V S++FS +GE LAS S D  + +W A
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  137 bits (346), Expect = 3e-32
 Identities = 78/206 (37%), Positives = 107/206 (51%), Gaps = 4/206 (1%)

Query: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
           +K    H G V  ++FSPD   LL+ SEDG V  W  ++   L    GH  PV   +FSP
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
            G+ F S   D   RLW     + LR+  GH   V    F P+S  +A+G  D+ V LWD
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD---IGHGLMVGELKGHTD 712
           V +G  +R+  GH+  I S  FSP    LATG+ D  V +WD   +   +    L+GH+ 
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193

Query: 713 TVCSLRFSRDGEILASGSMDNTVRLW 738
            +  L +S  G +LASGS D T+ +W
Sbjct: 194 NISCLCYSASG-LLASGSWDKTIHIW 218



 Score =  121 bits (303), Expect = 3e-27
 Identities = 63/156 (40%), Positives = 86/156 (55%)

Query: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
           H   V  + FSP G   ++G  D     W T   Q L    GH   V   RF P+ +  A
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           + S D TVRLWDV    C+R+  GH+  + +++FSP+ R LA+G  D RV+LWD+  G M
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           +  L GH D++ S  FS     LA+GS D+TV +WD
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175



 Score =  109 bits (273), Expect = 9e-24
 Identities = 74/242 (30%), Positives = 99/242 (40%), Gaps = 44/242 (18%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+GPV    FSPD +   S+S D TVRLW +    CL   KGH   V    FSP   
Sbjct: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD---------- 648
              SGG D+   LW     Q LR+  GH   +  + F P  N +ATGS D          
Sbjct: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178

Query: 649 ----------------------------------RTVRLWDVLNGNCVRIFTGHKGPIHS 674
                                             +T+ +W     + +    GH   + S
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238

Query: 675 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734
           + FSP+  +LA+      V +WD   G  +  LKG  D   +  F+ DG+IL SG+ D T
Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298

Query: 735 VR 736
            R
Sbjct: 299 RR 300



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 46/127 (36%), Positives = 65/127 (51%)

Query: 613 ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672
           AT   + ++ F  H  +VN + F P+   + TGS D  V  W+  +G  +    GH GP+
Sbjct: 7   ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV 66

Query: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732
               FSP+G   A+ + D  V LWD+     +  LKGH  +V ++ FS D   LASG  D
Sbjct: 67  KFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126

Query: 733 NTVRLWD 739
             V LWD
Sbjct: 127 KRVMLWD 133



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/82 (46%), Positives = 49/82 (59%)

Query: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721
           V+ F  H G ++S  FSP+G+ L TG+ DG V  W+   G ++  L GHT  V   RFS 
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 722 DGEILASGSMDNTVRLWDAIKA 743
           DG + AS S D TVRLWD  +A
Sbjct: 74  DGHLFASASCDCTVRLWDVARA 95


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  137 bits (345), Expect = 4e-32
 Identities = 74/213 (34%), Positives = 109/213 (51%), Gaps = 1/213 (0%)

Query: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSS-EDGTVRLWSLQTFTCLVGYKGHNYPVW 589
           KTA +L+ +  H+  V           LL++  +D  V LWS+    C++   GH  PV 
Sbjct: 8   KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67

Query: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649
             + +      V+G      R+W  +  + LR   GH A++    FHP   +VA+GS D 
Sbjct: 68  SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127

Query: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 709
            ++LWD+    CV  + GH   +  L FSP+G++LA+ A D  V LWD+  G M+ E  G
Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187

Query: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
           HT  V  + F  +  +LASGS D T+R WD  K
Sbjct: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220



 Score =  125 bits (315), Expect = 1e-28
 Identities = 65/208 (31%), Positives = 105/208 (50%), Gaps = 1/208 (0%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+ PV     +     +++ S+ G++R+W L+    L    GH   +    F PYG 
Sbjct: 59  LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
           +  SG  D   +LW       +  + GH   V C RF P+  ++A+ + D TV+LWD+  
Sbjct: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178

Query: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718
           G  +  F GH GP++ + F PN   LA+G++D  +  WD+    +V  ++G    V S+ 
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVL 238

Query: 719 FSRDGEILASGSMDN-TVRLWDAIKAFE 745
           F+ DG  L SG  D+  V  W+  + F+
Sbjct: 239 FNPDGCCLYSGCQDSLRVYGWEPERCFD 266



 Score =  124 bits (311), Expect = 3e-28
 Identities = 71/226 (31%), Positives = 107/226 (47%), Gaps = 12/226 (5%)

Query: 484 LIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESDDVLERIMDEKT 532
           L+A G  D  V +WS+               + SV+  +   LI   S     R+ D + 
Sbjct: 35  LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94

Query: 533 ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592
           A  L+ L GH   +    F P   ++ S S+D  ++LW ++   C+  Y+GH+  V   +
Sbjct: 95  AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154

Query: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
           FSP G +  S   D   +LW     + +  F GH   VN   FHPN   +A+GS+DRT+R
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214

Query: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG-RVLLWD 697
            WD+     V    G  GP+ S+ F+P+G  L +G  D  RV  W+
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 36/145 (24%), Positives = 53/145 (36%), Gaps = 31/145 (21%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C + +    Q +  +  + D   +A    D TV++W +T  K+ S               
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE-------------- 184

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
                              GH+GPV    F P+   L S S D T+R W L+ F  +   
Sbjct: 185 -----------------FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCI 227

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHD 606
           +G   PV    F+P G    SG  D
Sbjct: 228 EGEPGPVRSVLFNPDGCCLYSGCQD 252


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  136 bits (343), Expect = 7e-32
 Identities = 75/277 (27%), Positives = 140/277 (50%), Gaps = 11/277 (3%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521
           +T++D++ +   +A    D+ + +W+  P             + SV+ +   +L+   S 
Sbjct: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
           D   R+       +      H+ PV    FS D  +L ++SED ++++WS+     L   
Sbjct: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
             H + V   +FSP G   VS   D+  ++W T + Q +  F+  +   N   F+P+   
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200

Query: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
           +A+  +D+TV++WDV     ++ +  H G ++ ++F P+G +L T ++DG + + D+  G
Sbjct: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260

Query: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
            ++  L+GHT  V ++ FS+ GE+ ASG  D  V LW
Sbjct: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score =  102 bits (254), Expect = 1e-21
 Identities = 54/199 (27%), Positives = 85/199 (42%)

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GH   +     SP+   L ++S D  + LW+ +       Y GH   V   QFSP+G   
Sbjct: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
            S   DR  RLW  D       F  H A V    F  +  ++AT S D+++++W +    
Sbjct: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
            +     H   +    FSP+GR + + + D  + +WD  +   V            + F+
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195

Query: 721 RDGEILASGSMDNTVRLWD 739
             G  +AS   D TV++WD
Sbjct: 196 PSGTCIASAGSDQTVKVWD 214



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 51/159 (32%), Positives = 75/159 (47%)

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
           +KGH   +     SP G    +   D    LW    +     + GH   V   +F P+ N
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
            +A+ S DRTVRLW          F  H  P+ S+ FS +G+FLAT + D  + +W +  
Sbjct: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133

Query: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
              +  L  HT  V   +FS DG ++ S S D T+++WD
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 42/118 (35%), Positives = 59/118 (50%)

Query: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
           R F GH A +      PN   +AT S D  + LW+         + GHK  + S+ FSP+
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           G  LA+ + D  V LW         E K HT  V S+ FS DG+ LA+ S D ++++W
Sbjct: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 15/148 (10%)

Query: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL-------------SLIDKESDDVLERI 527
           D  LI     D T+++W  T K+   V   SD              + I     D   ++
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQC--VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212

Query: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
            D +    L+    HSG V   SF P  NYL+++S DGT+++  L     +   +GH  P
Sbjct: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272

Query: 588 VWDTQFSPYGYYFVSGGHDRVARLWATD 615
           V+   FS  G  F SGG D    LW T+
Sbjct: 273 VFTVSFSKGGELFASGGADTQVLLWRTN 300


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  135 bits (341), Expect = 1e-31
 Identities = 72/205 (35%), Positives = 108/205 (52%), Gaps = 1/205 (0%)

Query: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF-SP 595
           K+L  H  P+   + +   +  ++ S D T +LW   +   L   +GH   V+   F +P
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
           YG    +G  D+  +LW+ +  +    F GH A++ C  F+P S  VATGS D T +LWD
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205

Query: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
           + NG  V    GH   I SL+F+ +G  + TG+ D  V++WD   G  V  L GH   + 
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265

Query: 716 SLRFSRDGEILASGSMDNTVRLWDA 740
           S  F+ D  ++ +GSMD T +LWDA
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDA 290



 Score =  127 bits (320), Expect = 3e-29
 Identities = 76/280 (27%), Positives = 124/280 (44%), Gaps = 12/280 (4%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSV-------TPKKLRSVKQASDLS-----LIDKES 520
           LT V +    S    G  D T ++W         T +  R+V  A   +      I   S
Sbjct: 95  LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154

Query: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
            D   ++   +T        GH+  +   SF+P    + + S D T +LW +Q    +  
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
            +GH+  +    F+  G   ++G  D    +W  D  + + I  GH A+++   F+ + +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
            + TGS D+T +LWD  NG CV   TGH   I    F   G+ +AT + DG   ++    
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334

Query: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
              + +L+GH   +  + F+  G  L +GS D T R+WDA
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374



 Score =  118 bits (295), Expect = 2e-26
 Identities = 63/171 (36%), Positives = 90/171 (52%), Gaps = 1/171 (0%)

Query: 571 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630
           S  TF      K H  P+ +   +  G  F++G +DR  +LW T   + L    GH   V
Sbjct: 78  SNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV 137

Query: 631 NCTRF-HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
               F +P  + +ATGS D+T +LW V  G C   F GH   I  L+F+P    +ATG+ 
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197

Query: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
           D    LWDI +G  V  L+GH+  + SL F+  G+ + +GS D+TV +WDA
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248



 Score =  117 bits (294), Expect = 3e-26
 Identities = 63/246 (25%), Positives = 113/246 (45%), Gaps = 11/246 (4%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C++TF      +  +     S+L+A G  D+T ++W +   +     +     +I    +
Sbjct: 169 CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228

Query: 522 DVLERIM-----------DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570
              +RI+           D  T  ++ IL GH   +  ASF+ D + +L+ S D T +LW
Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288

Query: 571 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630
                 C+    GH+  + D+ F   G    +   D  AR+++    + +    GH  ++
Sbjct: 289 DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI 348

Query: 631 NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATD 690
           +   F+P  N++ TGS+D+T R+WD   G C+++  GH   I S  F+  G  + TG+ D
Sbjct: 349 SKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408

Query: 691 GRVLLW 696
               +W
Sbjct: 409 NTCRIW 414



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 15/55 (27%), Positives = 25/55 (45%), Gaps = 6/55 (10%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINL 761
           LK H   + ++  ++ G    +GS D T +LWD          ++  T  GH N+
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG------EELNTLEGHRNV 136


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  126 bits (317), Expect = 7e-29
 Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)

Query: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512
           Y F      +T V+ +    L+A G  D TVR+W    K            +RSV   SD
Sbjct: 17  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 76

Query: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
                  SDD   ++        L  L  H   V  A FSPD   ++S+S+D TV+LW  
Sbjct: 77  GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
            +  C+  Y  H   V    F P G    + G D   ++W    ++ L+ +  H A VN 
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
             FHP+ NY+ T S+D T+++ D++ G  +    GH+GP  ++ FS  G + A+G +D +
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 256

Query: 693 VLLW 696
           V++W
Sbjct: 257 VMVW 260



 Score =  110 bits (275), Expect = 5e-24
 Identities = 59/202 (29%), Positives = 96/202 (47%)

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GH   V   +FSP  + L S S D TVR+W          ++ H   V    F   G  F
Sbjct: 21  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
           V+   D+  ++WAT   + L   + H+  V C +F P+   + + S D+TV+LWD  +  
Sbjct: 81  VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
           CV  +  H G +  + F P+G  +A    D  V +WD+    ++   + H+  V  L F 
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200

Query: 721 RDGEILASGSMDNTVRLWDAIK 742
             G  L + S D+T+++ D ++
Sbjct: 201 PSGNYLITASSDSTLKILDLME 222



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 49/176 (27%), Positives = 76/176 (43%)

Query: 564 DGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF 623
           D  + +W ++  +    + GH   V    FSP G+   SG  D+  R+W  +      +F
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
             H A V    F  +     T S D+TV++W       +   + H   +    FSP+GR 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + + + D  V LWD      V     H   V  + F   G  +A+  MDNTV++WD
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C +++      +T VD     + IA    D+TV+VW V   +L    Q            
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 189

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
                               HS  V G SF P  NYL+++S D T+++  L     L   
Sbjct: 190 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 229

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
            GH  P     FS  G YF SGG D    +W ++
Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  126 bits (317), Expect = 7e-29
 Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)

Query: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512
           Y F      +T V+ +    L+A G  D TVR+W    K            +RSV   SD
Sbjct: 55  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114

Query: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
                  SDD   ++        L  L  H   V  A FSPD   ++S+S+D TV+LW  
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
            +  C+  Y  H   V    F P G    + G D   ++W    ++ L+ +  H A VN 
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
             FHP+ NY+ T S+D T+++ D++ G  +    GH+GP  ++ FS  G + A+G +D +
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294

Query: 693 VLLW 696
           V++W
Sbjct: 295 VMVW 298



 Score =  124 bits (310), Expect = 5e-28
 Identities = 74/277 (26%), Positives = 122/277 (44%), Gaps = 11/277 (3%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521
           +T VD + ++  +A G  DS + VW + P+            +  V  +    L+   S 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
           D   RI       E  +   H+  V    F  D    +++S+D TV++W+      L   
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
             H   V   +FSP G   VS   D+  +LW     + +  +  H   V    FHP+   
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
           +A    D TV++WDV     ++ +  H   ++ L+F P+G +L T ++D  + + D+  G
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261

Query: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
            ++  L GH     ++ FSR GE  ASG  D  V +W
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 57/199 (28%), Positives = 85/199 (42%)

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GH   V    FS +   L S S D  + +W ++  +    + GH   V    FSP G+  
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
            SG  D+  R+W  +      +F  H A V    F  +     T S D+TV++W      
Sbjct: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
            +   + H   +    FSP+GR + + + D  V LWD      V     H   V  + F 
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196

Query: 721 RDGEILASGSMDNTVRLWD 739
             G  +A+  MDNTV++WD
Sbjct: 197 PSGTCIAAAGMDNTVKVWD 215



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 49/159 (30%), Positives = 70/159 (44%)

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
           +KGH   V    FS       SG  D    +W          F GH   V C  F P+ +
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
            +A+GS D+TVR+W         +F  H   + S+ F  +G+   T + D  V +W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
              +  L  H + V   +FS DG ++ S S D TV+LWD
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 41/118 (34%), Positives = 60/118 (50%)

Query: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
           R F GH   V C  F  N+  +A+GS D  + +W +   +    FTGHK  +  + FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           G  LA+G+ D  V +W           + HT TV S+ F  DG+   + S D TV++W
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C +++      +T VD     + IA    D+TV+VW V   +L    Q            
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 227

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
                               HS  V G SF P  NYL+++S D T+++  L     L   
Sbjct: 228 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
            GH  P     FS  G YF SGG D    +W ++
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  126 bits (317), Expect = 7e-29
 Identities = 75/244 (30%), Positives = 115/244 (47%), Gaps = 11/244 (4%)

Query: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASD 512
           Y F      +T V+ +    L+A G  D TVR+W    K            +RSV   SD
Sbjct: 55  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114

Query: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
                  SDD   ++        L  L  H   V  A FSPD   ++S+S+D TV+LW  
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
            +  C+  Y  H   V    F P G    + G D   ++W    ++ L+ +  H A VN 
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
             FHP+ NY+ T S+D T+++ D++ G  +    GH+GP  ++ FS  G + A+G +D +
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294

Query: 693 VLLW 696
           V++W
Sbjct: 295 VMVW 298



 Score =  124 bits (310), Expect = 5e-28
 Identities = 74/277 (26%), Positives = 122/277 (44%), Gaps = 11/277 (3%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESD 521
           +T VD + ++  +A G  DS + VW + P+            +  V  +    L+   S 
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
           D   RI       E  +   H+  V    F  D    +++S+D TV++W+      L   
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
             H   V   +FSP G   VS   D+  +LW     + +  +  H   V    FHP+   
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201

Query: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
           +A    D TV++WDV     ++ +  H   ++ L+F P+G +L T ++D  + + D+  G
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261

Query: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
            ++  L GH     ++ FSR GE  ASG  D  V +W
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 57/199 (28%), Positives = 85/199 (42%)

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GH   V    FS +   L S S D  + +W ++  +    + GH   V    FSP G+  
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
            SG  D+  R+W  +      +F  H A V    F  +     T S D+TV++W      
Sbjct: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
            +   + H   +    FSP+GR + + + D  V LWD      V     H   V  + F 
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFH 196

Query: 721 RDGEILASGSMDNTVRLWD 739
             G  +A+  MDNTV++WD
Sbjct: 197 PSGTCIAAAGMDNTVKVWD 215



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 49/159 (30%), Positives = 70/159 (44%)

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
           +KGH   V    FS       SG  D    +W          F GH   V C  F P+ +
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
            +A+GS D+TVR+W         +F  H   + S+ F  +G+   T + D  V +W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
              +  L  H + V   +FS DG ++ S S D TV+LWD
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 41/118 (34%), Positives = 60/118 (50%)

Query: 621 RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
           R F GH   V C  F  N+  +A+GS D  + +W +   +    FTGHK  +  + FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           G  LA+G+ D  V +W           + HT TV S+ F  DG+   + S D TV++W
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 31/154 (20%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C +++      +T VD     + IA    D+TV+VW V   +L    Q            
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL----------- 227

Query: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
                               HS  V G SF P  NYL+++S D T+++  L     L   
Sbjct: 228 --------------------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267

Query: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
            GH  P     FS  G YF SGG D    +W ++
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  123 bits (309), Expect = 6e-28
 Identities = 80/292 (27%), Positives = 128/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSVTP-------------------------KKLRSVKQASDLSLI 516
           S L+A G  DST R+W+++                          K + S+   S+ +L+
Sbjct: 181 SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL 240

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI   K  +    L  H GP++   ++   N++LS+  D T  +W   T  
Sbjct: 241 ATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGE 299

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 300 AKQQFPFHSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWD 358

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG---------RFLATG 687
           P  N +A+ S D T+++W +   NCV     H   I+++ +SP G           LA+ 
Sbjct: 359 PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASA 418

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWD+  G+ +  L  H + V S+ FS DG  LASGS D  V +W+
Sbjct: 419 SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 16/215 (7%)

Query: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587
           +L GH   V+  +++P  + L S S D T R+W+L                +   G + P
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223

Query: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
               V    ++  G    +G +D  AR+W  D          H   +   +++   N++ 
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +  +G    
Sbjct: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRP 341

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           +   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 10/91 (10%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQ 766
           L+GH   V    ++   ++LASGS D+T R+W+         +++ T+ +  + L    +
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------SENSTSGSTQLVLRHCIR 216

Query: 767 ELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797
           E   G  +  +  V  L +     +LA G+Y
Sbjct: 217 E--GGQDVPSNKDVTSLDWNSEGTLLATGSY 245


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  118 bits (295), Expect = 2e-26
 Identities = 75/227 (33%), Positives = 116/227 (51%), Gaps = 19/227 (8%)

Query: 537 KILYGHSGPVYGA-SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
           K+L GH   V     F  +R  ++S S+D T+++WS  T  CL    GH   VW +Q   
Sbjct: 256 KVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR- 312

Query: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
                +SG  DR  ++W  +  + +    GH + V C   H     V +GS D T+R+WD
Sbjct: 313 -DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 369

Query: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
           +  G C+ +  GH   +  + +  +GR + +GA D  V +WD      +  L+GHT+ V 
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427

Query: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDD-FTTATGHINL 761
           SL+F  DG  + SGS+D ++R+W       D+ET +   T TGH +L
Sbjct: 428 SLQF--DGIHVVSGSLDTSIRVW-------DVETGNCIHTLTGHQSL 465



 Score =  117 bits (293), Expect = 4e-26
 Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 24/268 (8%)

Query: 485 IAGGFADSTVRVWS-VTPKKLRSV---------KQASDLSLIDKESDDVLERIMDEKTAS 534
           I  G  D+T++VWS VT K LR++          Q  D  +I   +D  L ++ + +T  
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL-KVWNAETGE 334

Query: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594
            +  LYGH+  V        R  ++S S D T+R+W ++T  CL    GH   V   Q+ 
Sbjct: 335 CIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 392

Query: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
             G   VSG +D + ++W  +    L    GH   V   +F  +  +V +GS D ++R+W
Sbjct: 393 --GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVW 448

Query: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HT 711
           DV  GNC+   TGH+     +    N   L +G  D  V +WDI  G  +  L+G   H 
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 506

Query: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
             V  L+F+++   + + S D TV+LWD
Sbjct: 507 SAVTCLQFNKN--FVITSSDDGTVKLWD 532



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASD----LSLI 516
           C  T +    G+ +  + D+  +I  G  D T++VW+  T + + ++   +     + L 
Sbjct: 295 CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 352

Query: 517 DKE----SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
           +K     S D   R+ D +T   L +L GH   V    +  D   ++S + D  V++W  
Sbjct: 353 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 410

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
           +T TCL   +GH   V+  QF   G + VSG  D   R+W  +    +    GH +  + 
Sbjct: 411 ETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG---HKGPIHSLTFSPNGRFLATGAT 689
                  N + +G+AD TV++WD+  G C++   G   H+  +  L F+ N  F+ T + 
Sbjct: 469 MEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSD 524

Query: 690 DGRVLLWDIGHG-----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734
           DG V LWD+  G     L+  E  G    V  +R S    + A GS + T
Sbjct: 525 DGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 574



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 40/134 (29%), Positives = 65/134 (48%), Gaps = 7/134 (5%)

Query: 607 RVARLWATDHYQPLRIFAGHLADV-NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
           R+   W     +  ++  GH   V  C +F    N + +GS D T+++W  + G C+R  
Sbjct: 242 RIDTNWRRGELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTL 299

Query: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
            GH G + S     N   + +G+TD  + +W+   G  +  L GHT TV  +      + 
Sbjct: 300 VGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KR 355

Query: 726 LASGSMDNTVRLWD 739
           + SGS D T+R+WD
Sbjct: 356 VVSGSRDATLRVWD 369


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  118 bits (295), Expect = 2e-26
 Identities = 75/227 (33%), Positives = 116/227 (51%), Gaps = 19/227 (8%)

Query: 537 KILYGHSGPVYGA-SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
           K+L GH   V     F  +R  ++S S+D T+++WS  T  CL    GH   VW +Q   
Sbjct: 374 KVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR- 430

Query: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
                +SG  DR  ++W  +  + +    GH + V C   H     V +GS D T+R+WD
Sbjct: 431 -DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487

Query: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
           +  G C+ +  GH   +  + +  +GR + +GA D  V +WD      +  L+GHT+ V 
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545

Query: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDD-FTTATGHINL 761
           SL+F  DG  + SGS+D ++R+W       D+ET +   T TGH +L
Sbjct: 546 SLQF--DGIHVVSGSLDTSIRVW-------DVETGNCIHTLTGHQSL 583



 Score =  117 bits (293), Expect = 4e-26
 Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 24/268 (8%)

Query: 485 IAGGFADSTVRVWS-VTPKKLRSV---------KQASDLSLIDKESDDVLERIMDEKTAS 534
           I  G  D+T++VWS VT K LR++          Q  D  +I   +D  L ++ + +T  
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL-KVWNAETGE 452

Query: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594
            +  LYGH+  V        R  ++S S D T+R+W ++T  CL    GH   V   Q+ 
Sbjct: 453 CIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510

Query: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
             G   VSG +D + ++W  +    L    GH   V   +F  +  +V +GS D ++R+W
Sbjct: 511 --GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVW 566

Query: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HT 711
           DV  GNC+   TGH+     +    N   L +G  D  V +WDI  G  +  L+G   H 
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624

Query: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
             V  L+F+++   + + S D TV+LWD
Sbjct: 625 SAVTCLQFNKN--FVITSSDDGTVKLWD 650



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASD----LSLI 516
           C  T +    G+ +  + D+  +I  G  D T++VW+  T + + ++   +     + L 
Sbjct: 413 CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470

Query: 517 DKE----SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
           +K     S D   R+ D +T   L +L GH   V    +  D   ++S + D  V++W  
Sbjct: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
           +T TCL   +GH   V+  QF   G + VSG  D   R+W  +    +    GH +  + 
Sbjct: 529 ETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG---HKGPIHSLTFSPNGRFLATGAT 689
                  N + +G+AD TV++WD+  G C++   G   H+  +  L F+ N  F+ T + 
Sbjct: 587 MEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSD 642

Query: 690 DGRVLLWDIGHG-----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734
           DG V LWD+  G     L+  E  G    V  +R S    + A GS + T
Sbjct: 643 DGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 98/467 (20%), Positives = 178/467 (38%), Gaps = 56/467 (11%)

Query: 317 LKRHLQEKQNNQIWNIVQEHLYI--DIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFF 374
           + R ++E+Q  Q+    +EH     ++    PR   Q D+  G L     R  +  +   
Sbjct: 33  MNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSS 92

Query: 375 GLLKEPEI-EVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAP----------- 422
           G  +E E  E    ++DEE E EE   ++      S  S  + +  +             
Sbjct: 93  GNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDL 152

Query: 423 PQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDS 482
           P +++  P    + K+ + ++     +   LG      +  YT        +A   T   
Sbjct: 153 PVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPC-KVSEYTSTTGLVPCSATPTTFGD 211

Query: 483 SLIAGGFADSTVRVWSVTP--------KKLRSVKQASDLSLIDKESDDV-------LERI 527
              A G      R+ SV P        K  +S      L  +D+  D         + ++
Sbjct: 212 LRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQV 271

Query: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK----- 582
           ++ +   +   L      +Y  SF   ++ L ++    T R W +     L+  +     
Sbjct: 272 IEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQ---TCRYWRILAEDNLLWREKCKEE 328

Query: 583 GHNYPVWDTQ---------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV-NC 632
           G + P+   +          SP+   ++     R+   W     +  ++  GH   V  C
Sbjct: 329 GIDEPLHIKRRKVIKPGFIHSPWKSAYIR--QHRIDTNWRRGELKSPKVLKGHDDHVITC 386

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
            +F    N + +GS D T+++W  + G C+R   GH G + S     N   + +G+TD  
Sbjct: 387 LQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRT 442

Query: 693 VLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + +W+   G  +  L GHT TV  +      + + SGS D T+R+WD
Sbjct: 443 LKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  118 bits (295), Expect = 2e-26
 Identities = 75/227 (33%), Positives = 116/227 (51%), Gaps = 19/227 (8%)

Query: 537 KILYGHSGPVYGA-SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
           K+L GH   V     F  +R  ++S S+D T+++WS  T  CL    GH   VW +Q   
Sbjct: 294 KVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR- 350

Query: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
                +SG  DR  ++W  +  + +    GH + V C   H     V +GS D T+R+WD
Sbjct: 351 -DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 407

Query: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
           +  G C+ +  GH   +  + +  +GR + +GA D  V +WD      +  L+GHT+ V 
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465

Query: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDD-FTTATGHINL 761
           SL+F  DG  + SGS+D ++R+W       D+ET +   T TGH +L
Sbjct: 466 SLQF--DGIHVVSGSLDTSIRVW-------DVETGNCIHTLTGHQSL 503



 Score =  117 bits (293), Expect = 4e-26
 Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 24/268 (8%)

Query: 485 IAGGFADSTVRVWS-VTPKKLRSV---------KQASDLSLIDKESDDVLERIMDEKTAS 534
           I  G  D+T++VWS VT K LR++          Q  D  +I   +D  L ++ + +T  
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL-KVWNAETGE 372

Query: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594
            +  LYGH+  V        R  ++S S D T+R+W ++T  CL    GH   V   Q+ 
Sbjct: 373 CIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 430

Query: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
             G   VSG +D + ++W  +    L    GH   V   +F  +  +V +GS D ++R+W
Sbjct: 431 --GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVW 486

Query: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HT 711
           DV  GNC+   TGH+     +    N   L +G  D  V +WDI  G  +  L+G   H 
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 544

Query: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
             V  L+F+++   + + S D TV+LWD
Sbjct: 545 SAVTCLQFNKN--FVITSSDDGTVKLWD 570



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASD----LSLI 516
           C  T +    G+ +  + D+  +I  G  D T++VW+  T + + ++   +     + L 
Sbjct: 333 CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 390

Query: 517 DKE----SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
           +K     S D   R+ D +T   L +L GH   V    +  D   ++S + D  V++W  
Sbjct: 391 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 448

Query: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
           +T TCL   +GH   V+  QF   G + VSG  D   R+W  +    +    GH +  + 
Sbjct: 449 ETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506

Query: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG---HKGPIHSLTFSPNGRFLATGAT 689
                  N + +G+AD TV++WD+  G C++   G   H+  +  L F+ N  F+ T + 
Sbjct: 507 MEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSD 562

Query: 690 DGRVLLWDIGHG-----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734
           DG V LWD+  G     L+  E  G    V  +R S    + A GS + T
Sbjct: 563 DGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 612



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 40/134 (29%), Positives = 65/134 (48%), Gaps = 7/134 (5%)

Query: 607 RVARLWATDHYQPLRIFAGHLADV-NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
           R+   W     +  ++  GH   V  C +F    N + +GS D T+++W  + G C+R  
Sbjct: 280 RIDTNWRRGELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTL 337

Query: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
            GH G + S     N   + +G+TD  + +W+   G  +  L GHT TV  +      + 
Sbjct: 338 VGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KR 393

Query: 726 LASGSMDNTVRLWD 739
           + SGS D T+R+WD
Sbjct: 394 VVSGSRDATLRVWD 407


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score =  117 bits (293), Expect = 4e-26
 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 4/214 (1%)

Query: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588
           +E  A++ K +  H+  +   SF+     +L++S DGT  LW +++   L  + GH   V
Sbjct: 139 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 198

Query: 589 WDTQFSPY--GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
                +P   G  FVSGG D+ A +W     Q ++ F  H +D+N  R++P+ +  A+GS
Sbjct: 199 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 258

Query: 647 ADRTVRLWDVLNGNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704
            D T RL+D+     V I++         S+ FS +GR L  G  D  + +WD+  G  V
Sbjct: 259 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318

Query: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             L GH + V +LR S DG    SGS D+T+R+W
Sbjct: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 14/250 (5%)

Query: 502 KKLRSVKQASDLSLIDKESDDVLERI--MDEKTASELKILYGHSGPVYGASFSPDRNYLL 559
           + L+   +     L D E   V ER+  + +      + L GH   V    +  D+  ++
Sbjct: 20  ESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV 79

Query: 560 SSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYGYYFVSGGHDRVARLWAT--D 615
           SSS+DG V +W   +FT    +       W     ++P G     GG D    ++    D
Sbjct: 80  SSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 137

Query: 616 HYQPL----RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP 671
             + +    +  A H   ++   F  +   + T S D T  LWDV +G  ++ F GH   
Sbjct: 138 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 197

Query: 672 IHSLTFSPN--GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729
           +  L  +P+  G    +G  D + ++WD+  G  V   + H   + S+R+   G+  ASG
Sbjct: 198 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 257

Query: 730 SMDNTVRLWD 739
           S D T RL+D
Sbjct: 258 SDDATCRLYD 267



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 41/197 (20%), Positives = 71/197 (36%), Gaps = 15/197 (7%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV--KQASDLSLIDKESD--------- 521
           L+A   T+    I     D T  +W V   +L        +D+  +D             
Sbjct: 156 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 215

Query: 522 --DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
             D    + D ++   ++    H   +    + P  +   S S+D T RL+ L+    + 
Sbjct: 216 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 275

Query: 580 GYKGHN--YPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP 637
            Y   +  +      FS  G    +G +D    +W       + I  GH   V+  R  P
Sbjct: 276 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 335

Query: 638 NSNYVATGSADRTVRLW 654
           +     +GS D T+R+W
Sbjct: 336 DGTAFCSGSWDHTLRVW 352



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 4/123 (3%)

Query: 494 VRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGAS--- 550
           V+ +      + SV+           SDD   R+ D +   E+ I Y     ++GAS   
Sbjct: 232 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI-YSKESIIFGASSVD 290

Query: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
           FS     L +   D T+ +W +   + +    GH   V   + SP G  F SG  D   R
Sbjct: 291 FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 350

Query: 611 LWA 613
           +WA
Sbjct: 351 VWA 353


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score =  117 bits (293), Expect = 4e-26
 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 4/214 (1%)

Query: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588
           +E  A++ K +  H+  +   SF+     +L++S DGT  LW +++   L  + GH   V
Sbjct: 181 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 240

Query: 589 WDTQFSPY--GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
                +P   G  FVSGG D+ A +W     Q ++ F  H +D+N  R++P+ +  A+GS
Sbjct: 241 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 300

Query: 647 ADRTVRLWDVLNGNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704
            D T RL+D+     V I++         S+ FS +GR L  G  D  + +WD+  G  V
Sbjct: 301 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360

Query: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             L GH + V +LR S DG    SGS D+T+R+W
Sbjct: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 14/250 (5%)

Query: 502 KKLRSVKQASDLSLIDKESDDVLERI--MDEKTASELKILYGHSGPVYGASFSPDRNYLL 559
           + L+   +     L D E   V ER+  + +      + L GH   V    +  D+  ++
Sbjct: 62  ESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV 121

Query: 560 SSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYGYYFVSGGHDRVARLWAT--D 615
           SSS+DG V +W   +FT    +       W     ++P G     GG D    ++    D
Sbjct: 122 SSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 179

Query: 616 HYQPL----RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP 671
             + +    +  A H   ++   F  +   + T S D T  LWDV +G  ++ F GH   
Sbjct: 180 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 239

Query: 672 IHSLTFSPN--GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729
           +  L  +P+  G    +G  D + ++WD+  G  V   + H   + S+R+   G+  ASG
Sbjct: 240 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 299

Query: 730 SMDNTVRLWD 739
           S D T RL+D
Sbjct: 300 SDDATCRLYD 309



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 41/197 (20%), Positives = 71/197 (36%), Gaps = 15/197 (7%)

Query: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV--KQASDLSLIDKESD--------- 521
           L+A   T+    I     D T  +W V   +L        +D+  +D             
Sbjct: 198 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 257

Query: 522 --DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
             D    + D ++   ++    H   +    + P  +   S S+D T RL+ L+    + 
Sbjct: 258 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 317

Query: 580 GYKGHN--YPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP 637
            Y   +  +      FS  G    +G +D    +W       + I  GH   V+  R  P
Sbjct: 318 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 377

Query: 638 NSNYVATGSADRTVRLW 654
           +     +GS D T+R+W
Sbjct: 378 DGTAFCSGSWDHTLRVW 394



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 4/123 (3%)

Query: 494 VRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGAS--- 550
           V+ +      + SV+           SDD   R+ D +   E+ I Y     ++GAS   
Sbjct: 274 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI-YSKESIIFGASSVD 332

Query: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
           FS     L +   D T+ +W +   + +    GH   V   + SP G  F SG  D   R
Sbjct: 333 FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 392

Query: 611 LWA 613
           +WA
Sbjct: 393 VWA 395


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 7e-26
 Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   SD +L+
Sbjct: 191 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLL 250

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 251 AMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE 309

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +       P++ F GH  +VN  ++ 
Sbjct: 310 AKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    CV     H   I+++ +SP G           LA+ 
Sbjct: 369 PSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASA 428

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWD+  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 55/215 (25%), Positives = 96/215 (44%), Gaps = 16/215 (7%)

Query: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587
           +L GH   V+  +++P  + L S S D T R+W+L                +   GH+ P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
               V    ++  G     G +D  AR+W T++         H   +   +++   NYV 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +  +G    
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHP 351

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 37/133 (27%), Positives = 67/133 (50%), Gaps = 15/133 (11%)

Query: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFT-------GHKGP 671
           +  GH ++V    ++P S+ +A+GS D T R+W++    NG   ++         GH  P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 672 ----IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727
               + SL ++ +G  LA G+ DG   +W   +G +   L  H   + +L++++ G  + 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 728 SGSMDNTVRLWDA 740
           S  +D T  +WDA
Sbjct: 293 SAGVDKTTIIWDA 305



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 24/93 (25%), Positives = 39/93 (41%), Gaps = 14/93 (15%)

Query: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK----------G 709
           N   +  GH+  +    ++P    LA+G+ D    +W++      G  +          G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 710 H----TDTVCSLRFSRDGEILASGSMDNTVRLW 738
           H       V SL ++ DG +LA GS D   R+W
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW 262


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 7e-26
 Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   SD +L+
Sbjct: 191 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLL 250

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 251 AMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE 309

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +       P++ F GH  +VN  ++ 
Sbjct: 310 AKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    CV     H   I+++ +SP G           LA+ 
Sbjct: 369 PSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASA 428

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWD+  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 55/215 (25%), Positives = 96/215 (44%), Gaps = 16/215 (7%)

Query: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587
           +L GH   V+  +++P  + L S S D T R+W+L                +   GH+ P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
               V    ++  G     G +D  AR+W T++         H   +   +++   NYV 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +  +G    
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHP 351

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 37/133 (27%), Positives = 67/133 (50%), Gaps = 15/133 (11%)

Query: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFT-------GHKGP 671
           +  GH ++V    ++P S+ +A+GS D T R+W++    NG   ++         GH  P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 672 ----IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727
               + SL ++ +G  LA G+ DG   +W   +G +   L  H   + +L++++ G  + 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 728 SGSMDNTVRLWDA 740
           S  +D T  +WDA
Sbjct: 293 SAGVDKTTIIWDA 305



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 24/93 (25%), Positives = 39/93 (41%), Gaps = 14/93 (15%)

Query: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK----------G 709
           N   +  GH+  +    ++P    LA+G+ D    +W++      G  +          G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 710 H----TDTVCSLRFSRDGEILASGSMDNTVRLW 738
           H       V SL ++ DG +LA GS D   R+W
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW 262


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  116 bits (291), Expect = 7e-26
 Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   SD +L+
Sbjct: 191 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLL 250

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 251 AMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE 309

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +       P++ F GH  +VN  ++ 
Sbjct: 310 AKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWD 368

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    CV     H   I+++ +SP G           LA+ 
Sbjct: 369 PSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASA 428

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWD+  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 429 SFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 55/215 (25%), Positives = 96/215 (44%), Gaps = 16/215 (7%)

Query: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587
           +L GH   V+  +++P  + L S S D T R+W+L                +   GH+ P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
               V    ++  G     G +D  AR+W T++         H   +   +++   NYV 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
           +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +  +G    
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF-ASCSTDMCIHVCRLGCDHP 351

Query: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
           V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 37/133 (27%), Positives = 67/133 (50%), Gaps = 15/133 (11%)

Query: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFT-------GHKGP 671
           +  GH ++V    ++P S+ +A+GS D T R+W++    NG   ++         GH  P
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 672 ----IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727
               + SL ++ +G  LA G+ DG   +W   +G +   L  H   + +L++++ G  + 
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVL 292

Query: 728 SGSMDNTVRLWDA 740
           S  +D T  +WDA
Sbjct: 293 SAGVDKTTIIWDA 305



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 24/93 (25%), Positives = 39/93 (41%), Gaps = 14/93 (15%)

Query: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK----------G 709
           N   +  GH+  +    ++P    LA+G+ D    +W++      G  +          G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 710 H----TDTVCSLRFSRDGEILASGSMDNTVRLW 738
           H       V SL ++ DG +LA GS D   R+W
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW 262


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  115 bits (288), Expect = 2e-25
 Identities = 72/259 (27%), Positives = 112/259 (43%), Gaps = 41/259 (15%)

Query: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
           +D L +++     + L   +GH+  +    F P  + L +SS D TV+LW L    C++ 
Sbjct: 372 EDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILT 431

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
           ++GH+  VW   +   G +  S   D+ +++W  +  +      GH   VN   F P SN
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 491

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI-- 698
            + T SAD+T+ +WD   G C +   GH   I+   F P G  +A+    G   LWD   
Sbjct: 492 TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551

Query: 699 ------------------------------GHGLM---------VGELKGHTDTVCSLRF 719
                                         G+G++         + +L GH +   ++ F
Sbjct: 552 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVF 611

Query: 720 SRDGEILASGSMDNTVRLW 738
           S DGEIL SG  D TVR W
Sbjct: 612 SHDGEILFSGGSDGTVRTW 630



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 52/160 (32%), Positives = 79/160 (49%)

Query: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
           ++ H  PV      P+    VS G DR+ ++        L    GH   ++   FHP+ +
Sbjct: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407

Query: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
            +AT S D TV+LWD+  G+C+  F GH   + S T+   G F+A+ + D    +WD+  
Sbjct: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNS 467

Query: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
                 L GHTD+V S+ F      L + S D T+ +WDA
Sbjct: 468 ERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 63/242 (26%), Positives = 98/242 (40%), Gaps = 4/242 (1%)

Query: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
           H  PV   S  P ++ L+S  ED   ++  L     L+   GH   + D  F P G    
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410

Query: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 661
           +   D   +LW       +  F GH   V    +H   N+VA+ S D+T ++WDV +  C
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470

Query: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721
                GH   ++S+ F P    L T + D  + +WD   G+    L GH  ++    F  
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530

Query: 722 DGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781
            G ++AS       +LWD  K    +  D   +    +N   + + L           V+
Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLA----QASGNGVI 586

Query: 782 HL 783
           HL
Sbjct: 587 HL 588



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 93/390 (23%), Positives = 147/390 (37%), Gaps = 54/390 (13%)

Query: 353 DAMVGSLAG--EAKREANKSKVFFGLLKEPEIEVPLDDEDE---EGENEEGKPKKKKPKK 407
           D +VG ++G  E  ++  +   + G    P+I+V    E E   EG  ++G  + ++  K
Sbjct: 249 DKVVGQISGLQETLKKLQRGHSYHG----PQIKVDHSREKENAPEGPTQKGLREAREQNK 304

Query: 408 DSIGSKSKKQDPNAPPQNRIPLPELKDSD----------KLDKIMNMKETTKR------- 450
                K   +D   P   + P P L  S           KL  I  + E           
Sbjct: 305 CKTKMKGNTKDSEFPIDMQ-PNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPH 363

Query: 451 ----VRLGPDCLPSICFYTFLNAYQGLTAVDVTD---------DSSLIAGGFADSTVRVW 497
               V  G D L  +      N    LT    TD             +A    D+TV++W
Sbjct: 364 KDILVSCGEDRLWKVLGLPKCNVL--LTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLW 421

Query: 498 SVTP-----------KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPV 546
            +             + + S    S  + +   S D   +I D  +      LYGH+  V
Sbjct: 422 DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSV 481

Query: 547 YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHD 606
               F P  N LL+SS D T+ +W  +T  C     GH + + D  F P G+   S    
Sbjct: 482 NSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541

Query: 607 RVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT 666
            V +LW      P+       +  N   F  +   +A  S +  + L D+ +G   ++  
Sbjct: 542 GVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM- 600

Query: 667 GHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
           GH+   H++ FS +G  L +G +DG V  W
Sbjct: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 6/126 (4%)

Query: 617 YQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN-GNCVRIFTG--HKGPIH 673
           Y+   IF  H   V+C    P+ + + +   DR   LW VL    C  + TG  H   + 
Sbjct: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTDWLS 398

Query: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733
              F P+G  LAT + D  V LWD+  G  +   +GH+  V S  +   G  +AS S+D 
Sbjct: 399 DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDK 458

Query: 734 TVRLWD 739
           T ++WD
Sbjct: 459 TSKIWD 464



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 1/73 (1%)

Query: 499 VTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL 558
           + P     V   S   ++ + S + +  ++D K+  E+  L GH    +   FS D   L
Sbjct: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSG-EIHKLMGHENEAHTVVFSHDGEIL 618

Query: 559 LSSSEDGTVRLWS 571
            S   DGTVR WS
Sbjct: 619 FSGGSDGTVRTWS 631


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  114 bits (285), Expect = 4e-25
 Identities = 66/246 (26%), Positives = 111/246 (45%), Gaps = 20/246 (8%)

Query: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
           S++   S+D   ++ D +T    + L GH+  V   SF      L S S D T++LW  Q
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633
            F C+    GH++ V      P G + VS   D+  ++W       ++ F GH   V   
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240

Query: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN------------- 680
           R + +   +A+ S D+TVR+W V    C      H+  +  ++++P              
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300

Query: 681 -------GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733
                  G FL +G+ D  + +WD+  G+ +  L GH + V  + F   G+ + S + D 
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360

Query: 734 TVRLWD 739
           T+R+WD
Sbjct: 361 TLRVWD 366



 Score =  110 bits (275), Expect = 5e-24
 Identities = 61/221 (27%), Positives = 103/221 (46%), Gaps = 20/221 (9%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH  PV    F P  + ++S+SED T+++W  +T       KGH   V D  F   G 
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
              S   D   +LW    ++ +R   GH  +V+     PN +++ + S D+T+++W+V  
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223

Query: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718
           G CV+ FTGH+  +  +  + +G  +A+ + D  V +W +       EL+ H   V  + 
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283

Query: 719 FS--------------------RDGEILASGSMDNTVRLWD 739
           ++                    + G  L SGS D T+++WD
Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324



 Score =  110 bits (275), Expect = 5e-24
 Identities = 69/288 (23%), Positives = 130/288 (45%), Gaps = 31/288 (10%)

Query: 483 SLIAGGFADSTVRVWSV-TPKKLRSVKQASDL----------SLIDKESDDVLERIMDEK 531
           S++     D+T++VW   T    R++K  +D            L+   S D+  ++ D +
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591
               ++ ++GH   V   +  P+ ++++S+S D T+++W +QT  C+  + GH   V   
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240

Query: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY---------- 641
           + +  G    S  +D+  R+W     +       H   V C  + P S+Y          
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300

Query: 642 ----------VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691
                     + +GS D+T+++WDV  G C+    GH   +  + F   G+F+ + A D 
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360

Query: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
            + +WD  +   +  L  H   V SL F +    + +GS+D TV++W+
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 60/204 (29%), Positives = 90/204 (44%), Gaps = 31/204 (15%)

Query: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
           C  TF    + +  V    D +LIA    D TVRVW V  K+ ++           +E +
Sbjct: 226 CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL---------REHE 276

Query: 522 DVLERI----------MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
            V+E I          + E T SE K   G  GP           +LLS S D T+++W 
Sbjct: 277 HVVECISWAPESSYSSISEATGSETK-KSGKPGP-----------FLLSGSRDKTIKMWD 324

Query: 572 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN 631
           + T  CL+   GH+  V    F   G + +S   D+  R+W   + + ++    H   V 
Sbjct: 325 VSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT 384

Query: 632 CTRFHPNSNYVATGSADRTVRLWD 655
              FH  + YV TGS D+TV++W+
Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score =  114 bits (285), Expect = 4e-25
 Identities = 70/242 (28%), Positives = 115/242 (47%), Gaps = 9/242 (3%)

Query: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
           + L GH   +Y   +  D   L+S+S+DG + +W   T   +      +  V    ++P 
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 597 GYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
           G Y   GG D +  ++       + +  R  AGH   ++C RF  + N + T S D T  
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCA 167

Query: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712
           LWD+  G     FTGH G + SL+ +P+ R   +GA D    LWD+  G+      GH  
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227

Query: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET---DDFTTATGHINLPENSQELL 769
            + ++ F  +G   A+GS D T RL+D ++A ++L T   D+       ++  ++ + LL
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD-LRADQELMTYSHDNIICGITSVSFSKSGRLLL 286

Query: 770 LG 771
            G
Sbjct: 287 AG 288



 Score =  107 bits (266), Expect = 6e-23
 Identities = 68/203 (33%), Positives = 99/203 (48%), Gaps = 3/203 (1%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+G +    F  D N +++SS D T  LW ++T      + GH   V     +P   
Sbjct: 139 LAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
            FVSG  D  A+LW        + F GH +D+N   F PN N  ATGS D T RL+D+  
Sbjct: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257

Query: 659 GNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCS 716
              +  ++       I S++FS +GR L  G  D    +WD       G L GH + V  
Sbjct: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317

Query: 717 LRFSRDGEILASGSMDNTVRLWD 739
           L  + DG  +A+GS D+ +++W+
Sbjct: 318 LGVTDDGMAVATGSWDSFLKIWN 340



 Score =  100 bits (250), Expect = 4e-21
 Identities = 71/250 (28%), Positives = 113/250 (45%), Gaps = 13/250 (5%)

Query: 503 KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 562
           K+ ++   +D  L+   S D    I D  T +++  +   S  V   +++P  NY+    
Sbjct: 57  KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGG 116

Query: 563 EDGTVRLWSLQTFTCLVGYK----GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618
            D    +++L+T    V       GH   +   +F        S G D    LW  +  Q
Sbjct: 117 LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQ 175

Query: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
               F GH  DV      P++    +G+ D + +LWDV  G C + FTGH+  I+++ F 
Sbjct: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235

Query: 679 PNGRFLATGATDGRVLLWDI--GHGLMVGELKGHTDTVC---SLRFSRDGEILASGSMDN 733
           PNG   ATG+ D    L+D+     LM      H + +C   S+ FS+ G +L +G  D 
Sbjct: 236 PNGNAFATGSDDATCRLFDLRADQELMT---YSHDNIICGITSVSFSKSGRLLLAGYDDF 292

Query: 734 TVRLWDAIKA 743
              +WDA+KA
Sbjct: 293 NCNVWDALKA 302



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 45/188 (23%), Positives = 78/188 (41%), Gaps = 2/188 (1%)

Query: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
           D + I   S D    + D +T  +     GH+G V   S +PD    +S + D + +LW 
Sbjct: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212

Query: 572 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA--GHLAD 629
           ++   C   + GH   +    F P G  F +G  D   RL+     Q L  ++    +  
Sbjct: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272

Query: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
           +    F  +   +  G  D    +WD L  +   +  GH   +  L  + +G  +ATG+ 
Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 690 DGRVLLWD 697
           D  + +W+
Sbjct: 333 DSFLKIWN 340



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 52/234 (22%), Positives = 90/234 (38%), Gaps = 25/234 (10%)

Query: 436 DKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQG-LTAVDVTDDSSLIAGGFADSTV 494
           D +  I N+K     VR+  +          L  + G L+     DD+ ++     D+T 
Sbjct: 118 DNICSIYNLKTREGNVRVSRE----------LAGHTGYLSCCRFLDDNQIVTSS-GDTTC 166

Query: 495 RVWSVTPKK-----------LRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 543
            +W +   +           + S+  A D  L    + D   ++ D +     +   GH 
Sbjct: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226

Query: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY--PVWDTQFSPYGYYFV 601
             +    F P+ N   + S+D T RL+ L+    L+ Y   N    +    FS  G   +
Sbjct: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286

Query: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
           +G  D    +W         + AGH   V+C     +   VATGS D  +++W+
Sbjct: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  112 bits (281), Expect = 1e-24
 Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   ++ +L+
Sbjct: 193 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 252

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 253 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 311

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 312 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 370

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    C+     H   I+++ +SP G           LA+ 
Sbjct: 371 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 430

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWDI  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 431 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)

Query: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579
           E  +S+  +L GH   V+  +++P  + L S S D T R+W+L                +
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 227

Query: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
              GH+ P    V    ++  G    +G +D  AR+W T+          H   +   ++
Sbjct: 228 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 286

Query: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
           +   NY+ +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +
Sbjct: 287 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 345

Query: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             +G    V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 346 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 13/33 (39%), Positives = 21/33 (63%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           L+GH   V    ++   ++LASGS D+T R+W+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  112 bits (281), Expect = 1e-24
 Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   ++ +L+
Sbjct: 193 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 252

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 253 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 311

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 312 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 370

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    C+     H   I+++ +SP G           LA+ 
Sbjct: 371 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 430

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWDI  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 431 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)

Query: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579
           E  +S+  +L GH   V+  +++P  + L S S D T R+W+L                +
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 227

Query: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
              GH+ P    V    ++  G    +G +D  AR+W T+          H   +   ++
Sbjct: 228 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 286

Query: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
           +   NY+ +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +
Sbjct: 287 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 345

Query: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             +G    V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 346 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 13/33 (39%), Positives = 21/33 (63%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           L+GH   V    ++   ++LASGS D+T R+W+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 209


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  112 bits (281), Expect = 1e-24
 Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   ++ +L+
Sbjct: 244 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 303

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 304 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 363 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 421

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    C+     H   I+++ +SP G           LA+ 
Sbjct: 422 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 481

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWDI  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 482 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)

Query: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579
           E  +S+  +L GH   V+  +++P  + L S S D T R+W+L                +
Sbjct: 219 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 278

Query: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
              GH+ P    V    ++  G    +G +D  AR+W T+          H   +   ++
Sbjct: 279 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 337

Query: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
           +   NY+ +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +
Sbjct: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 396

Query: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             +G    V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 397 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 13/33 (39%), Positives = 21/33 (63%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           L+GH   V    ++   ++LASGS D+T R+W+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  112 bits (281), Expect = 1e-24
 Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)

Query: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
           S L+A G  DST R+W++                         + K + S+   ++ +L+
Sbjct: 244 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 303

Query: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
              S D   RI  E   +    L  H GP++   ++   NY+LS+  D T  +W   T  
Sbjct: 304 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362

Query: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 363 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 421

Query: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
           P+   +A+ S D T+++W +    C+     H   I+++ +SP G           LA+ 
Sbjct: 422 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 481

Query: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           + D  V LWDI  G+    L  H + V S+ FS DG+ LASGS D  V +W+
Sbjct: 482 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)

Query: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579
           E  +S+  +L GH   V+  +++P  + L S S D T R+W+L                +
Sbjct: 219 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 278

Query: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
              GH+ P    V    ++  G    +G +D  AR+W T+          H   +   ++
Sbjct: 279 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 337

Query: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
           +   NY+ +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +
Sbjct: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 396

Query: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
             +G    V   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 397 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 13/33 (39%), Positives = 21/33 (63%)

Query: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
           L+GH   V    ++   ++LASGS D+T R+W+
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score =  112 bits (280), Expect = 1e-24
 Identities = 71/204 (34%), Positives = 100/204 (49%), Gaps = 5/204 (2%)

Query: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
           L GH+G +    F  D N +++SS D T  LW ++T    VG+ GH+  V     +P G 
Sbjct: 139 LPGHTGYLSCCRFLDD-NQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197

Query: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
            FVSG  D   +LW        + F GH +D+N   F PN     TGS D T RL+D L 
Sbjct: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LR 256

Query: 659 GNCVRIFTGHKG---PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
            +   +   H      I S+ FS +GR L  G  D    +WD   G   G L GH + V 
Sbjct: 257 ADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVS 316

Query: 716 SLRFSRDGEILASGSMDNTVRLWD 739
            L  + DG  +A+GS D+ +++W+
Sbjct: 317 CLGVTDDGMAVATGSWDSFLKIWN 340



 Score =  103 bits (257), Expect = 6e-22
 Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 6/215 (2%)

Query: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
           + L GH   +Y   +  D   L+S+S+DG + +W   T   +      +  V    ++P 
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 597 GYYFVSGGHDRVARLWA----TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
           G +   GG D +  +++      + +  R   GH   ++C RF  + N + T S D T  
Sbjct: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCA 167

Query: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712
           LWD+  G     F GH G + SL+ +P+GR   +GA D  + LWD+   +      GH  
Sbjct: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227

Query: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747
            + ++ F  +G    +GS D T RL+D ++A ++L
Sbjct: 228 DINAVAFFPNGYAFTTGSDDATCRLFD-LRADQEL 261



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 2/188 (1%)

Query: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
           D + I   S D    + D +T  +     GHSG V   S +PD    +S + D +++LW 
Sbjct: 153 DDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212

Query: 572 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA--GHLAD 629
           ++   C   + GH   +    F P GY F +G  D   RL+     Q L +++    +  
Sbjct: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICG 272

Query: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
           +    F  +   +  G  D    +WD + G+   +  GH   +  L  + +G  +ATG+ 
Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 690 DGRVLLWD 697
           D  + +W+
Sbjct: 333 DSFLKIWN 340



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 9/143 (6%)

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
           ++ G D V R+      +  R   GHLA +    +  +S  + + S D  + +WD    N
Sbjct: 33  ITAGLDPVGRI----QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI----GHGLMVGELKGHTDTVCS 716
            V         + +  ++P+G F+A G  D    ++ +    G+  +  EL GHT  +  
Sbjct: 89  KVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSC 148

Query: 717 LRFSRDGEILASGSMDNTVRLWD 739
            RF  D +I+ S S D T  LWD
Sbjct: 149 CRFLDDNQIITS-SGDTTCALWD 170


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  112 bits (279), Expect = 2e-24
 Identities = 63/201 (31%), Positives = 97/201 (48%), Gaps = 1/201 (0%)

Query: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
           GH+  V    + P   +L ++  D + RLW L+    ++  +GH+  V+D  F   G   
Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
            +GG D   R+W     + +    GHL ++    F PN  ++ATGS D T ++WD+    
Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440

Query: 661 CVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRF 719
           CV     H+  +  + F P +G FL TGA D    +W       +  L GH   V  L  
Sbjct: 441 CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI 500

Query: 720 SRDGEILASGSMDNTVRLWDA 740
           S DG+++A+ S D T +LW A
Sbjct: 501 SSDGQLIATCSYDRTFKLWMA 521



 Score =  110 bits (275), Expect = 5e-24
 Identities = 60/195 (30%), Positives = 92/195 (47%), Gaps = 1/195 (0%)

Query: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
           P    S  P    L S + DG+V+LWSL +   +   +GH   V    + P G +  +  
Sbjct: 283 PKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTC 342

Query: 605 HDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI 664
           +DR  RLW  +  + +    GH   V    FH + +   TG  D   R+WD+  G C+  
Sbjct: 343 YDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF 402

Query: 665 FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR-DG 723
             GH   I+ + FSPNG  +ATG+ D    +WD+     V  +  H + V  ++F    G
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 462

Query: 724 EILASGSMDNTVRLW 738
             L +G+ DNT ++W
Sbjct: 463 NFLLTGAYDNTAKIW 477



 Score =  102 bits (254), Expect = 1e-21
 Identities = 67/259 (25%), Positives = 110/259 (42%), Gaps = 15/259 (5%)

Query: 495 RVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL------YGHSGPVYG 548
           R+W       R++K+  +  L  KE  +       ++    L+ L       G   P+  
Sbjct: 178 RLWIANYSLPRAMKRLEEARL-HKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISY 236

Query: 549 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN--------YPVWDTQFSPYGYYF 600
             FSP+   L ++   G  +LWS+     L   +GHN        +P       P     
Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296

Query: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
            S   D   +LW+ D  +P+    GH   V    +HP+  ++ T   DR+ RLWD+    
Sbjct: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356

Query: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
            +    GH   ++ + F  +G    TG  D    +WD+  G  +  L+GH   +  + FS
Sbjct: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416

Query: 721 RDGEILASGSMDNTVRLWD 739
            +G  +A+GS DNT ++WD
Sbjct: 417 PNGYHIATGSGDNTCKVWD 435



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 47/172 (27%), Positives = 82/172 (47%), Gaps = 1/172 (0%)

Query: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN 585
           R+ D +   E+    GHS  VY  +F  D +   +   D   R+W L+T  C++  +GH 
Sbjct: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407

Query: 586 YPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVAT 644
             ++   FSP GY+  +G  D   ++W     + +     H   V   +F P + N++ T
Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT 467

Query: 645 GSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
           G+ D T ++W     + ++   GH+G +  L  S +G+ +AT + D    LW
Sbjct: 468 GAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 44/144 (30%), Positives = 70/144 (48%), Gaps = 1/144 (0%)

Query: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
           D SL      D   R+ D +T   +  L GH   +YG +FSP+  ++ + S D T ++W 
Sbjct: 376 DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 435

Query: 572 LQTFTCLVGYKGHNYPVWDTQFSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630
           L+   C+     H   V   +F P +G + ++G +D  A++W    + PL+  AGH   V
Sbjct: 436 LRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 495

Query: 631 NCTRFHPNSNYVATGSADRTVRLW 654
                  +   +AT S DRT +LW
Sbjct: 496 MGLDISSDGQLIATCSYDRTFKLW 519



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 35/156 (22%), Positives = 61/156 (39%), Gaps = 12/156 (7%)

Query: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTP-----------KKLRSVKQASDLSLIDKES 520
           G+  +    D SL   G  D+  RVW +             K++  +  + +   I   S
Sbjct: 367 GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGS 426

Query: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLV 579
            D   ++ D +    +  +  H   V G  F P   N+LL+ + D T ++W+   ++ L 
Sbjct: 427 GDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLK 486

Query: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
              GH   V     S  G    +  +DR  +LW  +
Sbjct: 487 TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,459,964
Number of Sequences: 37866
Number of extensions: 1859763
Number of successful extensions: 23444
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 438
Number of HSP's successfully gapped in prelim test: 753
Number of HSP's that attempted gapping in prelim test: 13107
Number of HSP's gapped (non-prelim): 6859
length of query: 800
length of database: 18,247,518
effective HSP length: 110
effective length of query: 690
effective length of database: 14,082,258
effective search space: 9716758020
effective search space used: 9716758020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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