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Search of human proteins with 209862883
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
(296 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 594 e-170
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 581 e-166
gi|116284376 histone deacetylase 2 [Homo sapiens] 80 2e-15
gi|13128864 histone deacetylase 6 [Homo sapiens] 76 4e-14
gi|13128860 histone deacetylase 1 [Homo sapiens] 75 5e-14
gi|8923769 histone deacetylase 8 [Homo sapiens] 72 4e-13
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 69 4e-12
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 69 4e-12
gi|13128862 histone deacetylase 3 [Homo sapiens] 68 1e-11
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 67 1e-11
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 67 1e-11
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 67 1e-11
gi|153085395 histone deacetylase 4 [Homo sapiens] 62 6e-10
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 61 1e-09
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 57 2e-08
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 57 2e-08
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 51 1e-06
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 46 3e-05
gi|4557389 complement component 8, alpha polypeptide precursor [... 29 4.3
gi|4885099 carbonic anhydrase III [Homo sapiens] 28 9.7
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 594 bits (1532), Expect = e-170
Identities = 296/296 (100%), Positives = 296/296 (100%)
Query: 1 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVL 60
MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVL
Sbjct: 1 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVL 60
Query: 61 RPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEG 120
RPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEG
Sbjct: 61 RPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEG 120
Query: 121 ISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTED 180
ISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTED
Sbjct: 121 ISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTED 180
Query: 181 DEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRG 240
DEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRG
Sbjct: 181 DEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRG 240
Query: 241 RRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 296
RRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Sbjct: 241 RRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 296
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 581 bits (1498), Expect = e-166
Identities = 296/319 (92%), Positives = 296/319 (92%), Gaps = 23/319 (7%)
Query: 1 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK---- 56
MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK
Sbjct: 29 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFA 88
Query: 57 -------------------RKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR 97
RKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR
Sbjct: 89 VATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDR 148
Query: 98 GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI 157
GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI
Sbjct: 149 GGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHI 208
Query: 158 YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217
YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL
Sbjct: 209 YPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 268
Query: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE 277
GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE
Sbjct: 269 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPE 328
Query: 278 SPSVSAQNSDTPLLPPAVP 296
SPSVSAQNSDTPLLPPAVP
Sbjct: 329 SPSVSAQNSDTPLLPPAVP 347
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 80.1 bits (196), Expect = 2e-15
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 19/201 (9%)
Query: 67 TGGTIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISR 123
TGG++ AG + + R A+N GG HH GFC DI LAI E ++ R
Sbjct: 209 TGGSV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQR 264
Query: 124 ATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIY-PGDRFAKQAIRRKVE-------LE 175
ID+D H G+G E F RV + + Y PG + K + +
Sbjct: 265 VLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMR 324
Query: 176 WGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVF 235
G +D+ Y + I K ++ + P VV G D L GDRLG +++ G K E
Sbjct: 325 DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVE--- 381
Query: 236 RMVRGRRVPILMVTSGGYQKR 256
+V+ +P+LM+ GGY R
Sbjct: 382 -VVKTFNLPLLMLGGGGYTIR 401
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 75.9 bits (185), Expect = 4e-14
Identities = 74/286 (25%), Positives = 114/286 (39%), Gaps = 42/286 (14%)
Query: 7 HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK---RKVLRPL 63
HP + +++ L+E L + + R A+E +LL H+ Y+ L+ + R L
Sbjct: 500 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTREL 559
Query: 64 RTQTGG---------TIMAGKLA----------VERGWAIN----VGGGFHHCSSDRGGG 100
++ T +LA V G +N V HH D G
Sbjct: 560 HRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619
Query: 101 FCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRH---I 157
FC + + +A + R I+D D H GNG + F DD V + ++
Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679
Query: 158 YP-GDRFAKQAIRRK------VELEWGTE---DDEYLDKVERNIKKSLQEHLPDVVVYNA 207
+P GD A I R V + W D +YL R + E P++V+ +A
Sbjct: 680 FPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSA 739
Query: 208 GTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 253
G D GD LGG +SP G L+ + GR I+++ GGY
Sbjct: 740 GFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGR---IILILEGGY 782
Score = 68.2 bits (165), Expect = 8e-12
Identities = 77/313 (24%), Positives = 127/313 (40%), Gaps = 55/313 (17%)
Query: 21 LKEEKLLSDSMLVEAREASEEDLLVVH---------TRRYLNELKRKVLRPL-------- 63
L +E LL + +AR A +E+L++VH T +Y+NE + +VL
Sbjct: 119 LIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 178
Query: 64 RTQTGGTIMAGKLA----------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113
+ + + +G + + G AI G HH G+C + + +A ++
Sbjct: 179 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARY 237
Query: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAK-------- 165
++ I R I+D D H G G + F D V + H Y RF
Sbjct: 238 AQQK-HRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSI---HRYEQGRFWPHLKASNWS 293
Query: 166 -----QAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217
Q + + W G D +Y+ + E P +V+ AG D L+GD
Sbjct: 294 TTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK 353
Query: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRT-ARIIADSILNLFG---LGL 273
G ++ +PAG + L+ + G+ +++ GGY R A ++ S+ L G L
Sbjct: 354 GEMAATPAGFAQLTHLLMGLAGGK---LILSLEGGYNLRALAEGVSASLHTLLGDPCPML 410
Query: 274 IGPESPSVSAQNS 286
P +P SAQ S
Sbjct: 411 ESPGAPCRSAQAS 423
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 75.5 bits (184), Expect = 5e-14
Identities = 61/200 (30%), Positives = 89/200 (44%), Gaps = 17/200 (8%)
Query: 67 TGGTIMAG-KLAVER-GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRA 124
TGG++ + KL ++ A+N GG HH GFC DI LAI E ++ R
Sbjct: 114 TGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRV 170
Query: 125 TIIDLDAHQGNGHERDFMDDKRVYIMDVYN-RHIYPGDRFAKQAIRRK-------VELEW 176
ID+D H G+G E F RV + + +PG + K L
Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRD 230
Query: 177 GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFR 236
G +D+ Y + + K ++ P VV G+D L GDRLG +++ G K E
Sbjct: 231 GIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVE---- 286
Query: 237 MVRGRRVPILMVTSGGYQKR 256
V+ +P+LM+ GGY R
Sbjct: 287 FVKSFNLPMLMLGGGGYTIR 306
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 72.4 bits (176), Expect = 4e-13
Identities = 72/285 (25%), Positives = 114/285 (40%), Gaps = 45/285 (15%)
Query: 13 KWGKVINFLKEEKLLSDSM-LVEAREASEEDLLVVHTRRYLNELKRK------------- 58
K +++ L E L M +V+ + AS E++ HT YL L++
Sbjct: 36 KRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIE 95
Query: 59 ------------VLRPLRTQTGGTIMAGKLAVERGW--AINVGGGFHHCSSDRGGGFCAY 104
+ G TI A + ++ AIN GG+HH D GFC
Sbjct: 96 YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYL 155
Query: 105 ADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPGDR 162
D L I L + E R +DLD H G+G E F +V + + ++ +PG
Sbjct: 156 NDAVLGILRLRRKFE---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTG 212
Query: 163 FAKQAIRRK-------VELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGD 215
K V ++ G +D++Y E +K+ Q P VV G D + GD
Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGD 272
Query: 216 RLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTAR 259
+ +++P GI K + + ++ L++ GGY TAR
Sbjct: 273 PMCSFNMTPVGIGK----CLKYILQWQLATLILGGGGYNLANTAR 313
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 69.3 bits (168), Expect = 4e-12
Identities = 70/312 (22%), Positives = 125/312 (40%), Gaps = 64/312 (20%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 53
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 700 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 759
Query: 54 ELK---RKVLRPLRTQTGGTIMAGKLAVERGWAIN------------------------- 85
K +K+L P+ + + G + V+ N
Sbjct: 760 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 819
Query: 86 -VGGGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 137
+ GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 820 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 878
Query: 138 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 183
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 879 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 938
Query: 184 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 241
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 939 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 998
Query: 242 RVPILMVTSGGY 253
+++ GG+
Sbjct: 999 ---VVLALEGGH 1007
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 69.3 bits (168), Expect = 4e-12
Identities = 70/312 (22%), Positives = 125/312 (40%), Gaps = 64/312 (20%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 53
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 699 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 758
Query: 54 ELK---RKVLRPLRTQTGGTIMAGKLAVERGWAIN------------------------- 85
K +K+L P+ + + G + V+ N
Sbjct: 759 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 818
Query: 86 -VGGGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 137
+ GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 819 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 877
Query: 138 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 183
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 878 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 937
Query: 184 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 241
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 938 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 997
Query: 242 RVPILMVTSGGY 253
+++ GG+
Sbjct: 998 ---VVLALEGGH 1006
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/183 (30%), Positives = 79/183 (43%), Gaps = 16/183 (8%)
Query: 83 AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFM 142
AIN GG HH GFC DI + I E ++ R ID+D H G+G + F
Sbjct: 126 AINWAGGLHHAKKFEASGFCYVNDIVIGI---LELLKYHPRVLYIDIDIHHGDGVQEAFY 182
Query: 143 DDKRVYIMDV--YNRHIYP--GDRFAKQAIRRK-----VELEWGTEDDEYLDKVERNIKK 193
RV + Y + +P GD + A + V L G +D Y + I +
Sbjct: 183 LTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQ 242
Query: 194 SLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 253
+ + P +V G D L DRLG ++S G E V V+ +P+L++ GGY
Sbjct: 243 VVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRG---HGECV-EYVKSFNIPLLVLGGGGY 298
Query: 254 QKR 256
R
Sbjct: 299 TVR 301
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 67.4 bits (163), Expect = 1e-11
Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 711
Query: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
+ L P R G I +A K+A
Sbjct: 712 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 771
Query: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 772 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 829
Query: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182
++ F D + + ++ + +PG + + + W G + D E
Sbjct: 830 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 889
Query: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240
YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G
Sbjct: 890 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 949
Query: 241 RRVPILMVTSGGY 253
R +++ GG+
Sbjct: 950 R---VVLALEGGH 959
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 67.4 bits (163), Expect = 1e-11
Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 708
Query: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
+ L P R G I +A K+A
Sbjct: 709 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 768
Query: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 769 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 826
Query: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182
++ F D + + ++ + +PG + + + W G + D E
Sbjct: 827 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 886
Query: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240
YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G
Sbjct: 887 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 946
Query: 241 RRVPILMVTSGGY 253
R +++ GG+
Sbjct: 947 R---VVLALEGGH 956
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 67.4 bits (163), Expect = 1e-11
Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 708
Query: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
+ L P R G I +A K+A
Sbjct: 709 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 768
Query: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 769 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 826
Query: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182
++ F D + + ++ + +PG + + + W G + D E
Sbjct: 827 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 886
Query: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240
YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G
Sbjct: 887 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 946
Query: 241 RRVPILMVTSGGY 253
R +++ GG+
Sbjct: 947 R---VVLALEGGH 956
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 62.0 bits (149), Expect = 6e-10
Identities = 76/312 (24%), Positives = 124/312 (39%), Gaps = 65/312 (20%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 53
G HP AG+ + + L+E L + R+A+ E+L VH+ + LN
Sbjct: 670 GSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLN 729
Query: 54 ELK---RKVLRPL-----RTQTGGTIM-------------AGKLAV-------------- 78
K +K+L L R GG + A +LAV
Sbjct: 730 RQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE 789
Query: 79 -ERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 137
+ G+A+ G HH GFC + + +A K L +R+ +S+ I+D D H GNG
Sbjct: 790 LKNGFAVVRPPG-HHAEESTPMGFCYFNSVAVAAKLLQQRLS-VSKILIVDWDVHHGNGT 847
Query: 138 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-------AIRRKVELEWGTE----DDEY 183
++ F D V M ++ + + +PG + + G + D EY
Sbjct: 848 QQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEY 907
Query: 184 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 241
L + E PDVV+ ++G D +EG LGG ++S + + + GR
Sbjct: 908 LAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR 967
Query: 242 RVPILMVTSGGY 253
I++ GG+
Sbjct: 968 ---IVLALEGGH 976
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 61.2 bits (147), Expect = 1e-09
Identities = 77/313 (24%), Positives = 126/313 (40%), Gaps = 55/313 (17%)
Query: 21 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK------RKVLRPLRTQTGG----- 69
L++ L + + AREASEE+L +VH+ Y++ ++ ++ L+ L Q
Sbjct: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
Query: 70 -TIMAGKLA---------------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113
T +LA V+ G A+ G HH GFC + ++ +A
Sbjct: 98 STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAAAH 156
Query: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF---------- 163
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 157 AKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESDAD 212
Query: 164 ---AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217
Q + V L W G + +Y+ + E P++V+ +AG D GD
Sbjct: 213 AVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE 272
Query: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---LGL 273
G + +P +L+ + GR + V GGY + A + ++ L G L
Sbjct: 273 GQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAPPL 329
Query: 274 IGPESPSVSAQNS 286
GP +P SA S
Sbjct: 330 SGPMAPCQSALES 342
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 57.0 bits (136), Expect = 2e-08
Identities = 67/279 (24%), Positives = 104/279 (37%), Gaps = 65/279 (23%)
Query: 7 HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVLRPLRTQ 66
HP AG+ + + L+E L S + R+AS E+L VH+ R++ L L+
Sbjct: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
Query: 67 TGGTIMAGKLAVERGWAINVGG-------------------------------------- 88
G +AG LA + GG
Sbjct: 603 NGK--LAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 660
Query: 89 -GF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERD 140
GF HH GFC + + +A + L ++ + S+ I+D D H GNG ++
Sbjct: 661 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQT 719
Query: 141 FMDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDK 186
F D V + ++ + +PG + A V + W D EYL
Sbjct: 720 FYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAA 779
Query: 187 VERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 223
+ +E PD+V+ +AG D EG LGG +S
Sbjct: 780 FRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 818
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 57.0 bits (136), Expect = 2e-08
Identities = 67/279 (24%), Positives = 104/279 (37%), Gaps = 65/279 (23%)
Query: 7 HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVLRPLRTQ 66
HP AG+ + + L+E L S + R+AS E+L VH+ R++ L L+
Sbjct: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
Query: 67 TGGTIMAGKLAVERGWAINVGG-------------------------------------- 88
G +AG LA + GG
Sbjct: 640 NGK--LAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 697
Query: 89 -GF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERD 140
GF HH GFC + + +A + L ++ + S+ I+D D H GNG ++
Sbjct: 698 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQT 756
Query: 141 FMDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDK 186
F D V + ++ + +PG + A V + W D EYL
Sbjct: 757 FYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAA 816
Query: 187 VERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 223
+ +E PD+V+ +AG D EG LGG +S
Sbjct: 817 FRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 855
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 51.2 bits (121), Expect = 1e-06
Identities = 49/207 (23%), Positives = 86/207 (41%), Gaps = 50/207 (24%)
Query: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 708
Query: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
+ L P R G I +A K+A
Sbjct: 709 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 768
Query: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 769 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 826
Query: 137 HERDFMDDKRVYIMDVY---NRHIYPG 160
++ F D + + ++ + +PG
Sbjct: 827 TQQAFYADPSILYISLHRYDEGNFFPG 853
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 46.2 bits (108), Expect = 3e-05
Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 32/170 (18%)
Query: 21 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK------RKVLRPLRTQTGG----- 69
L++ L + + AREASEE+L +VH+ Y++ ++ ++ L+ L Q
Sbjct: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
Query: 70 -TIMAGKLA---------------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113
T +LA V+ G A+ G HH GFC + ++ +A
Sbjct: 98 STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAAAH 156
Query: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF 163
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 157 AKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRF 202
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 29.3 bits (64), Expect = 4.3
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 70 TIMAGKLAVERGWAINVGGGF--HHCSSDRGGGFCAYADITLAIKFLFERVEG 120
T G L ++ INVGGG HC GGG A +A++ + RV G
Sbjct: 374 TCFGGSLGIQYEDKINVGGGLSGDHCKK-FGGGKTERARKAMAVEDIISRVRG 425
>gi|4885099 carbonic anhydrase III [Homo sapiens]
Length = 260
Score = 28.1 bits (61), Expect = 9.7
Identities = 15/54 (27%), Positives = 23/54 (42%)
Query: 146 RVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHL 199
RV D Y+R + G R+ L WG+ DD + +K + + HL
Sbjct: 67 RVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL 120
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.140 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,014,792
Number of Sequences: 37866
Number of extensions: 478802
Number of successful extensions: 1328
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1267
Number of HSP's gapped (non-prelim): 33
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.