Search of human proteins with 205360943

Search of human proteins with 205360943

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
         (492 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...  1051   0.0  
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...  1051   0.0  
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   333   2e-91
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         277   1e-74
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   252   5e-67
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   252   6e-67
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          249   5e-66
gi|223942069 enterokinase precursor [Homo sapiens]                    247   2e-65
gi|29244926 corin [Homo sapiens]                                      226   4e-59
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             217   2e-56
gi|33695155 hepsin [Homo sapiens]                                     211   1e-54
gi|4504481 hepsin [Homo sapiens]                                      211   1e-54
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        208   8e-54
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          204   1e-52
gi|4503627 coagulation factor XI precursor [Homo sapiens]             203   3e-52
gi|11415040 matriptase [Homo sapiens]                                 202   4e-52
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          194   1e-49
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           194   2e-49
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         191   1e-48
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       191   1e-48
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        191   2e-48
gi|148613878 acrosin precursor [Homo sapiens]                         190   3e-48
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           189   4e-48
gi|110815798 ovochymase 1 [Homo sapiens]                              189   6e-48
gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo sap...   186   5e-47
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   183   3e-46
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   183   3e-46
gi|21614531 testisin isoform 2 [Homo sapiens]                         181   1e-45
gi|13994276 marapsin [Homo sapiens]                                   180   3e-45
gi|117956391 protease, serine, 33 [Homo sapiens]                      180   3e-45

>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score = 1051 bits (2717), Expect = 0.0
 Identities = 492/492 (100%), Positives = 492/492 (100%)

Query: 1   MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 60
           MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
Sbjct: 38  MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 97

Query: 61  SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 120
           SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
Sbjct: 98  SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 157

Query: 121 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 180
           DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
Sbjct: 158 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 217

Query: 181 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 240
           GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
Sbjct: 218 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 277

Query: 241 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 300
           CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
Sbjct: 278 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 337

Query: 301 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
           PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
Sbjct: 338 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 397

Query: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420
           VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
Sbjct: 398 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 457

Query: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
           TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
Sbjct: 458 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 517

Query: 481 TDWIYRQMRADG 492
           TDWIYRQMRADG
Sbjct: 518 TDWIYRQMRADG 529


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score = 1051 bits (2717), Expect = 0.0
 Identities = 492/492 (100%), Positives = 492/492 (100%)

Query: 1   MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 60
           MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
Sbjct: 1   MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 60

Query: 61  SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 120
           SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
Sbjct: 61  SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC 120

Query: 121 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 180
           DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
Sbjct: 121 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY 180

Query: 181 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 240
           GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
Sbjct: 181 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR 240

Query: 241 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 300
           CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
Sbjct: 241 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK 300

Query: 301 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
           PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
Sbjct: 301 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360

Query: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420
           VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
Sbjct: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420

Query: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
           TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
Sbjct: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480

Query: 481 TDWIYRQMRADG 492
           TDWIYRQMRADG
Sbjct: 481 TDWIYRQMRADG 492


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  333 bits (854), Expect = 2e-91
 Identities = 189/412 (45%), Positives = 242/412 (58%), Gaps = 21/412 (5%)

Query: 89  LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
           + +G   +  ALA GL   F    CS     C SS  CI     CDGVS C  GEDE RC
Sbjct: 52  IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107

Query: 149 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 208
           VR+ G N +LQV+++   SW  +C DDW  +Y   AC  +G+ + + SS  +   S    
Sbjct: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164

Query: 209 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 261
           F +   S  ++   D    L+HS    + C+S  VV+L+C ACG     S  SRIVGG  
Sbjct: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222

Query: 262 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 321
           +L   WPWQ SL  Q  H+CGGS+ITP WI+TAAHCV   L  P  WT   G++  S + 
Sbjct: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD-LYLPKSWTIQVGLV--SLLD 279

Query: 322 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCW 380
             A  + VEK++ H  Y  K   NDIALMKL  PLTFN++++PVCLPN        ++CW
Sbjct: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCW 339

Query: 381 ISGWGATEE-KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG 439
            SGWGATE+  G  S VLN A V LI  + CN R VY  +I+P+M+CAG+L G VDSCQG
Sbjct: 340 TSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQG 399

Query: 440 DSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 491
           DSGGPLV  +  +W L+G TS+G GCA+  +PGVY  V  F DWI+ QM  D
Sbjct: 400 DSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERD 451


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  277 bits (709), Expect = 1e-74
 Identities = 162/462 (35%), Positives = 241/462 (52%), Gaps = 32/462 (6%)

Query: 47  SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT----------LGTFLV 96
           SP   Y  R     + P+  +  +S   T  T ++        T          +G  L+
Sbjct: 115 SPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLL 174

Query: 97  GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 155
             AL   L+  F   +  ++GI   +   +C   +  CDGV  C    DE  CVR     
Sbjct: 175 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK 233

Query: 156 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 214
            +L++YS     W P+C  +WN++Y    C+ +G+++   +++    D + S S ++ N+
Sbjct: 234 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS 293

Query: 215 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 274
           +     I + L+ S+ C S+  +SL+C  CG+    +   RIVGG  A    WPWQVSLH
Sbjct: 294 T-----IQESLHRSE-CPSQRYISLQCSHCGLR---AMTGRIVGGALASDSKWPWQVSLH 344

Query: 275 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 330
               H+CGG++I  +W++TAAHC     EK L     W  +AG      +   A   + +
Sbjct: 345 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE 399

Query: 331 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 390
           +I + NY  +  + DIALM+L KPLT +  + P CLP  G      + CWI+G+G T E 
Sbjct: 400 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET 459

Query: 391 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 449
             KTS  L   +V LI+ ++CN   VYD+ +TP M+CAG L+G  DSCQGDSGGPLV  +
Sbjct: 460 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ 519

Query: 450 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 491
           NN W+L G TSWG+GC +  +PGVY  V     WIY +M ++
Sbjct: 520 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESE 561


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  252 bits (644), Expect = 5e-67
 Identities = 144/375 (38%), Positives = 201/375 (53%), Gaps = 36/375 (9%)

Query: 133 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 181
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136

Query: 182 RAACRDMGYKNNFY----SSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVV 237
             ACR MGY             +V+ + ++  +++  S+G             C S ++V
Sbjct: 137 ETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCLSGSLV 184

Query: 238 SLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHC 297
           SL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++TAAHC
Sbjct: 185 SLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC 241

Query: 298 VEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTF 357
             K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ PLTF
Sbjct: 242 FRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQFPLTF 297

Query: 358 NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCNSRYVY 416
           +  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN+   Y
Sbjct: 298 SGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAY 357

Query: 417 DNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGN 476
              +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     PGVY  
Sbjct: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTK 416

Query: 477 VMVFTDWIYRQMRAD 491
           V  + +WIY   +A+
Sbjct: 417 VSAYLNWIYNVWKAE 431


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  252 bits (643), Expect = 6e-67
 Identities = 146/380 (38%), Positives = 205/380 (53%), Gaps = 41/380 (10%)

Query: 133 CDGVSHCPGGEDENRCVRLY--GP---------NFILQVYSSQRKSWHPVCQDDWNENYG 181
           CDG   CP GEDE  CV+ +  GP            LQV  S   +W   C D++ E   
Sbjct: 77  CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA 136

Query: 182 RAACRDMGY--KNNFYSSQ-------GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACS 232
             ACR MGY  K  F + +        +V+ + ++  +++  S+G             C 
Sbjct: 137 ETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG------------PCL 184

Query: 233 SKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIV 292
           S ++VSL C+ACG +L + R   +VGGE A   +WPWQVS+     HVCGGSI+ P W++
Sbjct: 185 SGSLVSLHCLACGKSLKTPR---VVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVL 241

Query: 293 TAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQ 352
           TAAHC  K   + ++W   AG  +       A  ++  +  +P Y    K+NDIALMKLQ
Sbjct: 242 TAAHCFRKH-TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY---PKDNDIALMKLQ 297

Query: 353 KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK-GKTSEVLNAAKVLLIETQRCN 411
            PLTF+  V+P+CLP     L P    WI GWG T++  GK S++L  A V +I++ RCN
Sbjct: 298 FPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCN 357

Query: 412 SRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRP 471
           +   Y   +T  M+CAG  +G VD+CQGDSGGPL+   +  W ++G  SWG GC     P
Sbjct: 358 ADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTP 416

Query: 472 GVYGNVMVFTDWIYRQMRAD 491
           GVY  V  + +WIY   +A+
Sbjct: 417 GVYTKVSAYLNWIYNVWKAE 436


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  249 bits (635), Expect = 5e-66
 Identities = 132/341 (38%), Positives = 181/341 (53%), Gaps = 9/341 (2%)

Query: 150 RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD---SGS 206
           R+   +F+L+     +  W  VC + W+   G   C  +G+    +     + D   + S
Sbjct: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172

Query: 207 TSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGA 266
             F +L+   G   + +     + C+S  VVSLRC  CG        SRIVGG+S  PG 
Sbjct: 173 QEFAQLSPRLGGF-LEEAWQPRNNCTSGQVVSLRCSECGAR---PLASRIVGGQSVAPGR 228

Query: 267 WPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK-PLNNPWHWTAFAGILRQSFMFYGAG 325
           WPWQ S+ +   H CGGS++ P W+VTAAHC+    L     W   AG++  S +    G
Sbjct: 229 WPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQG 288

Query: 326 YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWG 385
             VE++I HP Y ++  + D+AL++LQ  L F+D V  VCLP           CW+SGWG
Sbjct: 289 ALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWG 348

Query: 386 ATEEKGK-TSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGP 444
            T      +S++L    V L  TQ CNS  VY   +TP M+CAG+L G  D+CQGDSGGP
Sbjct: 349 HTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGP 408

Query: 445 LVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIY 485
           LV    + W L+G  SWG GCA+   PGVY  V  F DWI+
Sbjct: 409 LVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  247 bits (630), Expect = 2e-65
 Identities = 137/379 (36%), Positives = 204/379 (53%), Gaps = 14/379 (3%)

Query: 113  CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYG--PNFILQVYSSQRKSWHP 170
            C     +C  +G C+   N CDG  HC  G DE  CVR +    N    V    +  WH 
Sbjct: 643  CKADHFQC-KNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHT 701

Query: 171  VCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 230
             C ++W        C+ +G  +   S      D G   F+KLNT+    D +  L  S  
Sbjct: 702  ACAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGP--FVKLNTAP---DGHLILTPSQQ 756

Query: 231  CSSKAVVSLRCI--ACGVNLNSSRQS-RIVGGESALPGAWPWQVSLHVQNVHVCGGSIIT 287
            C   +++ L+C   +CG  L +   + +IVGG +A  GAWPW V L+     +CG S+++
Sbjct: 757  CLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVS 816

Query: 288  PEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQ--VEKVISHPNYDSKTKNND 345
             +W+V+AAHCV      P  WTA  G+  +S +         +++++ +P+Y+ + K+ND
Sbjct: 817  SDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDND 876

Query: 346  IALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLI 405
            IA+M L+  + + D ++P+CLP    +  P + C I+GWG    +G T+ +L  A V L+
Sbjct: 877  IAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLL 936

Query: 406  ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGC 465
              +RC  +    N IT  MICAG+ +G +DSCQGDSGGPL+  +NN W+L G TS+G  C
Sbjct: 937  SNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKC 995

Query: 466  AKAYRPGVYGNVMVFTDWI 484
            A   RPGVY  V  FT+WI
Sbjct: 996  ALPNRPGVYARVSRFTEWI 1014



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 14/125 (11%)

Query: 112 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENR--CVRLYGPNFILQVYSSQRKSWH 169
           +C      C  + TCI    +CDG  +CP G DE+   C  +    F+L   S   ++ H
Sbjct: 183 ECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATH 242

Query: 170 --------PVCQDDWNENYGRAACRDMGYKNNFYSS-QGIVDDSGSTSFMKLN---TSAG 217
                    VCQ     N G +        N +Y+    I +  GS+  ++ +   T+ G
Sbjct: 243 YPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPG 302

Query: 218 NVDIY 222
            + I+
Sbjct: 303 TIRIF 307


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  226 bits (576), Expect = 4e-59
 Identities = 138/391 (35%), Positives = 200/391 (51%), Gaps = 22/391 (5%)

Query: 111  SKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRL---YGPNFILQVYSSQRKS 167
            S C +  +EC ++  C++   WCDG + C    DE  CV L      +  L V+ +  + 
Sbjct: 653  SFCQDDELEC-ANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATE- 710

Query: 168  WHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKK 224
             H VC D W E   + AC+ MG      +   I +      ++ L++   S     +++ 
Sbjct: 711  -HHVCADGWQEILSQLACKQMGLGEPSVTKL-IQEQEKEPRWLTLHSNWESLNGTTLHEL 768

Query: 225  LYHSDACSSKAVVSLRCIA--CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ-NVHVC 281
            L +  +C S++ +SL C    CG    +    RI+GG ++ PG WPWQ SL  + + H+C
Sbjct: 769  LVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHIC 828

Query: 282  GGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGI--LRQSFMFYGAGYQVEKVISHPNYDS 339
            G  +I  +W++T AHC E    N   W    GI  L    +F    + V+ +I HP Y  
Sbjct: 829  GCVLIAKKWVLTVAHCFEGR-ENAAVWKVVLGINNLDHPSVFMQTRF-VKTIILHPRYSR 886

Query: 340  KTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNA 399
               + DI++++L + ++    V+PVCLPNP   L+P+  C+I+GWG      K    L  
Sbjct: 887  AVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG--HMGNKMPFKLQE 944

Query: 400  AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGD 458
             +V +I  + C S Y     IT  MICAG+  G VDSC GDSGGPLV  K    W L G 
Sbjct: 945  GEVRIISLEHCQS-YFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGL 1003

Query: 459  TSWGSGC-AKAYRPGVYGNVMVFTDWIYRQM 488
            TSWGS C +K   PGVY NV  F +WI RQ+
Sbjct: 1004 TSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)

Query: 112 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
           +CS S  +C  SG C+  S  CDG + C    DE  C
Sbjct: 579 ECSPSHFKC-RSGQCVLASRRCDGQADCDDDSDEENC 614



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 13/36 (36%), Positives = 17/36 (47%)

Query: 113 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
           C + G+    +G CI  +  CDG   C  G DE  C
Sbjct: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENC 414



 Score = 29.6 bits (65), Expect = 6.5
 Identities = 14/36 (38%), Positives = 17/36 (47%), Gaps = 1/36 (2%)

Query: 113 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
           CS +   C + G C+N S  CDG   C    DE  C
Sbjct: 306 CSENLFHCHT-GKCLNYSLVCDGYDDCGDLSDEQNC 340


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  217 bits (552), Expect = 2e-56
 Identities = 109/260 (41%), Positives = 157/260 (60%), Gaps = 10/260 (3%)

Query: 238 SLRCIACGVN--LNSSRQSRIVGGESALPGAWPWQVSLHVQNV---HVCGGSIITPEWIV 292
           SLR    G N    +   +RIVGG ++  G WPWQVSL V+     H+CGGS+I  +W++
Sbjct: 371 SLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVL 430

Query: 293 TAAHCVEK-PLNNPWHWTAFAGILRQSFMFYGAGY-QVEKVISHPNYDSKTKNNDIALMK 350
           TAAHC +  PL + W    ++GIL  S +     + Q++++I H NY     N+DIAL+K
Sbjct: 431 TAAHCFDGLPLQDVWR--IYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIK 488

Query: 351 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC 410
           LQ PL + +  KP+CLP+ G        CW++GWG ++EKG+   +L    + L+  + C
Sbjct: 489 LQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEEC 548

Query: 411 NSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYR 470
             RY  D  IT  M+CAG+ +G  D+C+GDSGGPLV   N +W L+G TSWG GCA+  +
Sbjct: 549 QKRY-QDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQ 607

Query: 471 PGVYGNVMVFTDWIYRQMRA 490
           PGVY  V  + DWI  + ++
Sbjct: 608 PGVYTKVAEYMDWILEKTQS 627


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  211 bits (537), Expect = 1e-54
 Identities = 118/346 (34%), Positives = 174/346 (50%), Gaps = 17/346 (4%)

Query: 158 LQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLN-TSA 216
           L V+     +W  +C    N      +C +MG+      S+  V  +G+           
Sbjct: 63  LMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDE 122

Query: 217 GNVDIYKKLYHSDA---CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL 273
           G +   ++L    +   C     ++  C  CG         RIVGG     G WPWQVSL
Sbjct: 123 GRLPHTQRLLEVISVCDCPRGRFLAAICQDCG--RRKLPVDRIVGGRDTSLGRWPWQVSL 180

Query: 274 HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVIS 333
                H+CGGS+++ +W++TAAHC  +       W  FAG + Q+   +G    V+ V+ 
Sbjct: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASP-HGLQLGVQAVVY 239

Query: 334 HPNY------DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGAT 387
           H  Y      +S+  +NDIAL+ L  PL   + ++PVCLP  G  L   ++C ++GWG T
Sbjct: 240 HGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT 299

Query: 388 EEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV- 446
           +  G+ + VL  A+V +I    CN    Y N I P M CAG+ +G +D+CQGDSGGP V 
Sbjct: 300 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVC 359

Query: 447 ---TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 489
               S+   W L G  SWG+GCA A +PGVY  V  F +WI++ ++
Sbjct: 360 EDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  211 bits (537), Expect = 1e-54
 Identities = 118/346 (34%), Positives = 174/346 (50%), Gaps = 17/346 (4%)

Query: 158 LQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLN-TSA 216
           L V+     +W  +C    N      +C +MG+      S+  V  +G+           
Sbjct: 63  LMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDE 122

Query: 217 GNVDIYKKLYHSDA---CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL 273
           G +   ++L    +   C     ++  C  CG         RIVGG     G WPWQVSL
Sbjct: 123 GRLPHTQRLLEVISVCDCPRGRFLAAICQDCG--RRKLPVDRIVGGRDTSLGRWPWQVSL 180

Query: 274 HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVIS 333
                H+CGGS+++ +W++TAAHC  +       W  FAG + Q+   +G    V+ V+ 
Sbjct: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASP-HGLQLGVQAVVY 239

Query: 334 HPNY------DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGAT 387
           H  Y      +S+  +NDIAL+ L  PL   + ++PVCLP  G  L   ++C ++GWG T
Sbjct: 240 HGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT 299

Query: 388 EEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV- 446
           +  G+ + VL  A+V +I    CN    Y N I P M CAG+ +G +D+CQGDSGGP V 
Sbjct: 300 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVC 359

Query: 447 ---TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 489
               S+   W L G  SWG+GCA A +PGVY  V  F +WI++ ++
Sbjct: 360 EDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  208 bits (530), Expect = 8e-54
 Identities = 110/286 (38%), Positives = 161/286 (56%), Gaps = 14/286 (4%)

Query: 209 FMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQ--------SRIVGG- 259
           +  L T   ++ I K  +      SK + +L    CG+ + SS           RIV G 
Sbjct: 151 YQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGR 210

Query: 260 ESALPGAWPWQVSLH-VQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS 318
           E+A+ G WPWQ SL  + + H CG S+I+  W++TAAHC  K   +P  W A  G    +
Sbjct: 211 ETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKN-KDPTQWIATFGA---T 266

Query: 319 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 378
                    V K+I H NY  +T  NDIAL++L   + F+++V+ VCLP+  + L P+  
Sbjct: 267 ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTS 326

Query: 379 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ 438
            +++G+G+  + G     L  A+V  I T  CN + VYD LITP M+CAGF++G +D+C+
Sbjct: 327 VFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACK 386

Query: 439 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484
           GDSGGPLV   ++IW+++G  SWG  CA   +PGVY  V  + DWI
Sbjct: 387 GDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  204 bits (519), Expect = 1e-52
 Identities = 103/244 (42%), Positives = 139/244 (56%), Gaps = 5/244 (2%)

Query: 245 GVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNN 304
           G +L +  + RI+GG  A  G+WPWQVSL + N H CGGS+I   WI+TAAHC     +N
Sbjct: 176 GPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSN-SN 234

Query: 305 PWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPV 364
           P  W A +GI   S  F     +V  ++ H NY S T  NDIAL++L+  +TF   +  V
Sbjct: 235 PRDWIATSGI---STTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSV 291

Query: 365 CLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAM 424
           CLP     + P    +++GWGA E  G T   L   +V +I    CN+ + Y+  I   M
Sbjct: 292 CLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGM 351

Query: 425 ICAGFLQGNVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDW 483
           +CAG  QG VD+CQGDSGGPLV      +W+++G  SWG  C    +PGVY  V  + DW
Sbjct: 352 LCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDW 411

Query: 484 IYRQ 487
           I +Q
Sbjct: 412 IRQQ 415


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  203 bits (517), Expect = 3e-52
 Identities = 103/244 (42%), Positives = 146/244 (59%), Gaps = 14/244 (5%)

Query: 255 RIVGGESALPGAWPWQVSLHVQNV---HVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAF 311
           RIVGG +++ G WPWQV+LH  +    H+CGGSII  +WI+TAAHC    + +P     +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG-VESPKILRVY 445

Query: 312 AGILRQSFM-----FYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCL 366
           +GIL QS +     F+G    V+++I H  Y       DIAL+KL+  + + D  +P+CL
Sbjct: 446 SGILNQSEIKEDTSFFG----VQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501

Query: 367 PNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMIC 426
           P+ G        CW++GWG  + + K    L  AK+ L+  + C  RY   + IT  MIC
Sbjct: 502 PSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRY-RGHKITHKMIC 560

Query: 427 AGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYR 486
           AG+ +G  D+C+GDSGGPL    N +W L+G TSWG GCA+  RPGVY NV+ + DWI  
Sbjct: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620

Query: 487 QMRA 490
           + +A
Sbjct: 621 KTQA 624


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  202 bits (515), Expect = 4e-52
 Identities = 132/397 (33%), Positives = 190/397 (47%), Gaps = 43/397 (10%)

Query: 123 SGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGR 182
           +G CI     CDG + C    DE  C    G  F  +    +   W     +D  +N   
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520

Query: 183 AAC------------RDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 230
             C            + +             D S   S  K+N        Y+ L  +  
Sbjct: 521 QGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCL--NGL 578

Query: 231 CSSKAVVSLRCIA------------CGVNLNS-SRQSRIVGGESALPGAWPWQVSLHVQN 277
           C SK   +  C              C   L S +RQ+R+VGG  A  G WPWQVSLH   
Sbjct: 579 CLSKG--NPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALG 636

Query: 278 V-HVCGGSIITPEWIVTAAHCVEKP----LNNPWHWTAFAGILRQSFMFYGAGYQ---VE 329
             H+CG S+I+P W+V+AAHC         ++P  WTAF G+  QS      G Q   ++
Sbjct: 637 QGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQS-QRSAPGVQERRLK 695

Query: 330 KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE 389
           ++ISHP ++  T + DIAL++L+KP  ++ +V+P+CLP+   +    +  W++GWG T+ 
Sbjct: 696 RIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQY 755

Query: 390 KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPL--VT 447
            G  + +L   ++ +I    C +  +    ITP M+C GFL G VDSCQGDSGGPL  V 
Sbjct: 756 GGTGALILQKGEIRVINQTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVE 813

Query: 448 SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484
           +   I +  G  SWG GCA+  +PGVY  + +F DWI
Sbjct: 814 ADGRI-FQAGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  194 bits (494), Expect = 1e-49
 Identities = 128/389 (32%), Positives = 184/389 (47%), Gaps = 50/389 (12%)

Query: 113 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVC 172
           C      C SSG C+  +  CDGV+ C    DE  CV                 S  P C
Sbjct: 358 CPVGSFRC-SSGLCVPQAQRCDGVNDCFDESDELFCV-----------------SPQPAC 399

Query: 173 QDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKKLYHSD 229
                  +G   C      + F   +   D+   T  +  N      GN   ++K     
Sbjct: 400 NTSSFRQHGPLIC------DGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQ---- 449

Query: 230 ACSSKAVVSLRCI------ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGG 283
             ++K   ++ C        C  + +SS   RI+GG   L G WPWQVSLH      CG 
Sbjct: 450 --NAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGA 507

Query: 284 SIITPEWIVTAAHCVE-KPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTK 342
           S+I+ EW+++AAHC     L++P  WTA  G+  Q    + +   V +++ H  Y+S+T 
Sbjct: 508 SVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVS--PVRRIVVHEYYNSQTF 565

Query: 343 NNDIALMKLQ--KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE-KGKTSEVLNA 399
           + DIAL++L    P T   L++P+C+P  G  ++  + CW++GWG   E   K S VL  
Sbjct: 566 DYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQ 625

Query: 400 AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK--NNIWWLIG 457
           A+V LI+   C S Y    +IT  M+CAG + G  D+C+GDSGGPL   +  +  W L G
Sbjct: 626 AEVELIDQTLCVSTY---GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTG 682

Query: 458 DTSWGSGCAKAYRPGVYGNVMVFTDWIYR 486
             SWG G  +   PGVY  V  F  WI++
Sbjct: 683 IVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  194 bits (493), Expect = 2e-49
 Identities = 125/371 (33%), Positives = 171/371 (46%), Gaps = 65/371 (17%)

Query: 119 ECDSSGTCINPSNWCDGVSHCPGGEDENRCVR-LYGPNFILQVYS-SQRKSWHPVCQDDW 176
           +C    TCI+    CDG   C  G DE +C   +    F  Q    S  K  +P C    
Sbjct: 496 QCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCD--- 552

Query: 177 NENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAV 236
               GR  CRD                 GS                    H D       
Sbjct: 553 ----GRPDCRD-----------------GSDE-----------------EHCD------- 567

Query: 237 VSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAH 296
                  CG+   SSR   IVGG  +  G WPWQ SL V+  H+CGG++I   W++TAAH
Sbjct: 568 -------CGLQGPSSR---IVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAH 617

Query: 297 CV-EKPLNNPWHWTAFAGILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKP 354
           C  E  + +   WT F G + Q+  + G   ++V +++ HP ++  + + D+AL++L  P
Sbjct: 618 CFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHP 677

Query: 355 LTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY 414
           +  +  V+PVCLP      +P   CWI+GWGA  E G  S  L    V LI    C+  Y
Sbjct: 678 VVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVY 737

Query: 415 VYDNLITPAMICAGFLQGNVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGV 473
            Y   +TP M+CAG+ +G  D+CQGDSGGPLV  + +  W+L G  SWG GC +    GV
Sbjct: 738 RYQ--VTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGV 795

Query: 474 YGNVMVFTDWI 484
           Y  +     WI
Sbjct: 796 YTRITGVISWI 806



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 14/30 (46%), Positives = 16/30 (53%), Gaps = 3/30 (10%)

Query: 120 CDSSGTCINPSNWCDGVSHCPGGEDENRCV 149
           C  +G C+     CDGV  CP G DE  CV
Sbjct: 464 CSVNGLCVPA---CDGVKDCPNGLDERNCV 490



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 15/47 (31%), Positives = 19/47 (40%), Gaps = 1/47 (2%)

Query: 110 GSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC-VRLYGPN 155
           G  C     +C+       P+  CDG   C  G DE  C   L GP+
Sbjct: 528 GVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPS 574


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  191 bits (486), Expect = 1e-48
 Identities = 99/245 (40%), Positives = 138/245 (56%), Gaps = 9/245 (3%)

Query: 244 CGVNLNSS--RQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 301
           CG   + +  +  RIVGG     G WPWQ SL     H CG ++I   W+V+AAHC    
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTT- 236

Query: 302 LNNPWHWTAFAGI-LRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
             NP  WTA  G+ ++ S M  G    + ++I H  Y   + + DI+L +L  P+ + + 
Sbjct: 237 YKNPARWTASFGVTIKPSKMKRG----LRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292

Query: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420
           V  VCLP+     QP  + +++G+GA +  G +   L  A+V LI+   CN    Y++ I
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAI 352

Query: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTS-KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 479
           TP M+CAG L+G  D+CQGDSGGPLV+S   +IW+L G  SWG  CAK  +PGVY  V  
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412

Query: 480 FTDWI 484
             DWI
Sbjct: 413 LRDWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  191 bits (486), Expect = 1e-48
 Identities = 99/245 (40%), Positives = 138/245 (56%), Gaps = 9/245 (3%)

Query: 244 CGVNLNSS--RQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 301
           CG   + +  +  RIVGG     G WPWQ SL     H CG ++I   W+V+AAHC    
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTT- 236

Query: 302 LNNPWHWTAFAGI-LRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
             NP  WTA  G+ ++ S M  G    + ++I H  Y   + + DI+L +L  P+ + + 
Sbjct: 237 YKNPARWTASFGVTIKPSKMKRG----LRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292

Query: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI 420
           V  VCLP+     QP  + +++G+GA +  G +   L  A+V LI+   CN    Y++ I
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAI 352

Query: 421 TPAMICAGFLQGNVDSCQGDSGGPLVTS-KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 479
           TP M+CAG L+G  D+CQGDSGGPLV+S   +IW+L G  SWG  CAK  +PGVY  V  
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTA 412

Query: 480 FTDWI 484
             DWI
Sbjct: 413 LRDWI 417


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  191 bits (484), Expect = 2e-48
 Identities = 91/233 (39%), Positives = 135/233 (57%), Gaps = 7/233 (3%)

Query: 254 SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313
           ++IV G+S+L GAWPWQ S+  +  H CG S+I+  W+++AAHC  K  NN   WT   G
Sbjct: 183 NKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK-NNSKDWTVNFG 241

Query: 314 IL-RQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMM 372
           I+  + +M      +V+ +I H NY S   ++DIAL++L + ++F + ++ +CLP   M 
Sbjct: 242 IVVNKPYMTR----KVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMK 297

Query: 373 LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQG 432
           L       ++GWG     G    +L    + +I+ + CN+ Y Y   +T  M+CAGF+ G
Sbjct: 298 LSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSG 357

Query: 433 NVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484
             D+CQ DSGGPL      NIW L+G  SWG GC K  +PGVY  V  + +WI
Sbjct: 358 EADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  190 bits (482), Expect = 3e-48
 Identities = 103/261 (39%), Positives = 146/261 (55%), Gaps = 24/261 (9%)

Query: 244 CGVNLNSSRQS--RIVGGESALPGAWPWQVSLHV-----QNVHVCGGSIITPEWIVTAAH 296
           CG+    + Q   RIVGG++A  GAWPW VSL +        H CGGS++   W++TAAH
Sbjct: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88

Query: 297 CVEKPLNNPWHWTAFAGILRQSFMFYGAGYQV---------EKVISHPNYDSKTKNNDIA 347
           C     NN   W    G      + YG    V         EK+I H  Y+S T+ NDIA
Sbjct: 89  CFVGK-NNVHDWRLVFGAKE---ITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIA 144

Query: 348 LMKLQKPLTFNDLVKPVCLPN-PGMMLQPEQLCWISGWGATEEKG-KTSEVLNAAKVLLI 405
           L+++  P++    + P CLP+    + +  Q CW++GWG  EEK  + S +L  A+V LI
Sbjct: 145 LVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLI 204

Query: 406 ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV--TSKNNIWWLIGDTSWGS 463
           +   CNS   Y+  + P  +CAG+  G +D+CQGDSGGPL+   SK + + ++G TSWG 
Sbjct: 205 DLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGV 264

Query: 464 GCAKAYRPGVYGNVMVFTDWI 484
           GCA+A RPG+Y     + +WI
Sbjct: 265 GCARAKRPGIYTATWPYLNWI 285


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  189 bits (481), Expect = 4e-48
 Identities = 103/244 (42%), Positives = 138/244 (56%), Gaps = 6/244 (2%)

Query: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 303
           CG+        RIVGG  A PG +PWQ SL     H CG +II   W+V+AAHC  +   
Sbjct: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNE-FQ 249

Query: 304 NPWHWTAFAGILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVK 362
           +P  W A+ G    S         QV +++ HP Y++ T + D+A+++L  PL F   ++
Sbjct: 250 DPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQ 309

Query: 363 PVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNLIT 421
           PVCLP    +  P + C ISGWG  +E      EVL  A V L++   C S  +Y + +T
Sbjct: 310 PVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLT 367

Query: 422 PAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
             M+CAG+L G VDSCQGDSGGPLV  + +  ++L G  SWG GCA+A RPGVY  V   
Sbjct: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427

Query: 481 TDWI 484
            DWI
Sbjct: 428 RDWI 431



 Score =  174 bits (440), Expect = 2e-43
 Identities = 101/246 (41%), Positives = 135/246 (54%), Gaps = 14/246 (5%)

Query: 244  CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQN-VHVCGGSIITPEWIVTAAHCVEKPL 302
            CG  L  +  +RIVGG +A  G WPWQVSL ++   H CG  ++   W+++AAHC +   
Sbjct: 817  CG--LAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-Y 873

Query: 303  NNPWHWTAFAGILRQSFMFYGAGYQVEKVI---SHPNYDSKTKNNDIALMKLQKPLTFND 359
             +P  W AF G    S    GA  Q+E+V     HP Y+  T + D+AL++L  P+  + 
Sbjct: 874  GDPKQWAAFLGTPFLS----GAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSR 929

Query: 360  LVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL 419
            LV+P+CLP P         C I+GWG+  E G  +  L  A V L+  Q C  R  Y   
Sbjct: 930  LVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTC--RRFYPVQ 987

Query: 420  ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 478
            I+  M+CAGF QG VDSC GD+GGPL   + +  W L G TSWG GC + + PGVY  V 
Sbjct: 988  ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVA 1047

Query: 479  VFTDWI 484
                WI
Sbjct: 1048 AVRGWI 1053



 Score =  168 bits (426), Expect = 9e-42
 Identities = 94/250 (37%), Positives = 136/250 (54%), Gaps = 11/250 (4%)

Query: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLN 303
           CG      + +R+VGG  A  G  PWQVSL   + H CG +++   W+++AAHC     N
Sbjct: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC----FN 547

Query: 304 NPWHWTAFAGILRQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
           +       A +   S +  G       + +V+ HP Y+    + D+A+++L  PL FN  
Sbjct: 548 HTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607

Query: 361 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS-EVLNAAKVLLIETQRCNSRYVYDNL 419
           ++PVCLP         + C ISGWG T+E   T  E+L  A V +I+ + C+   +Y+  
Sbjct: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFS 665

Query: 420 ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVM 478
           +T  MICAGFL+G VDSCQGDSGGPL   +   +++L G  SWG GCA+  +PGVY  + 
Sbjct: 666 LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRIT 725

Query: 479 VFTDWIYRQM 488
               WI   M
Sbjct: 726 RLKGWILEIM 735


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  189 bits (479), Expect = 6e-48
 Identities = 100/237 (42%), Positives = 141/237 (59%), Gaps = 10/237 (4%)

Query: 255 RIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGI 314
           RI GGE A P  WPWQV L     + CGG+II P WI+TAAHCV+   NNP  WT  AG 
Sbjct: 574 RIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCVQLK-NNPLSWTIIAGD 632

Query: 315 LRQSFMFYGAGYQVEK---VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGM 371
             ++     +  QV +   +I H ++++ + ++DIAL++L  PL +N +V+PVCLP+   
Sbjct: 633 HDRNLK--ESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAE 690

Query: 372 MLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY--VYDNLITPAMICAGF 429
            L   ++C ++GWG+    G  +  L   +V ++E + C   Y   +   IT  MICAGF
Sbjct: 691 PLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGF 750

Query: 430 -LQGNVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484
              G  D CQGDSGGPLV   +N  + L G  SWG+GC + ++PGV+  VM+F DWI
Sbjct: 751 AASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWI 807



 Score =  142 bits (358), Expect = 7e-34
 Identities = 93/277 (33%), Positives = 140/277 (50%), Gaps = 27/277 (9%)

Query: 237 VSLRCIACGVNLNSSRQ-------SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPE 289
           + L+C    VN+ S          SRI    ++     PWQVSL     H CGGS+I  +
Sbjct: 21  LGLKCGIRMVNMKSKEPAVGSRFFSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQED 80

Query: 290 WIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKT-KNN 344
            +VTAAHC+    EK L N    +    + ++          V K+I+HP Y+S+   + 
Sbjct: 81  RVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQ--EQNIPVSKIITHPEYNSREYMSP 138

Query: 345 DIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLL 404
           DIAL+ L+  + F + V+P+CLP+    ++P  LC  SGWG   +  + S VL   ++ +
Sbjct: 139 DIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSSGWGKISKTSEYSNVLQEMELPI 198

Query: 405 IETQRCNSRYVYDNL--ITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGDTSW 461
           ++ + CN+     NL  +   M+CAGF    +D+CQGDSGGPLV  +   IW L G TSW
Sbjct: 199 MDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSW 258

Query: 462 GSGCAKAYRP----------GVYGNVMVFTDWIYRQM 488
            +GCA    P          G++  V    D+I + +
Sbjct: 259 VAGCAGGSVPVRNNHVKASLGIFSKVSELMDFITQNL 295


>gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
           sapiens]
          Length = 344

 Score =  186 bits (471), Expect = 5e-47
 Identities = 119/285 (41%), Positives = 153/285 (53%), Gaps = 20/285 (7%)

Query: 89  LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
           + +G   +  ALA GL   F    CS     C SS  CI     CDGVS C  GEDE RC
Sbjct: 52  IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107

Query: 149 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 208
           VR+ G N +LQV+++   SW  +C DDW  +Y   AC  +G+ + + SS  +   S    
Sbjct: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164

Query: 209 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 261
           F +   S  ++   D    L+HS    + C+S  VV+L+C ACG     S  SRIVGG  
Sbjct: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222

Query: 262 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 321
           +L   WPWQ SL  Q  H+CGGS+ITP WI+TAAHCV   L  P  WT   G++  S + 
Sbjct: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCV-YDLYLPKSWTIQVGLV--SLLD 279

Query: 322 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 365
             A  + VEK++ H  Y  K   NDIALMKL  PLTFN     +C
Sbjct: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNGTSGSLC 324


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  183 bits (465), Expect = 3e-46
 Identities = 94/244 (38%), Positives = 133/244 (54%), Gaps = 7/244 (2%)

Query: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302
           +CG  +     +RI  G  A   AWPWQ SL   N+H CG ++I+  W+VTAAHC +K  
Sbjct: 174 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK-Y 232

Query: 303 NNPWHWT-AFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 361
            NP  WT +F   +    M       V + I H  Y S  +  DIA++++   +TF+D +
Sbjct: 233 KNPHQWTVSFGTKINPPLM----KRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDI 288

Query: 362 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLIT 421
           + +CLP      QP     I+G+GA    G++   L  A+V +I    C    VY N I 
Sbjct: 289 RQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIK 348

Query: 422 PAMICAGFLQGNVDSCQGDSGGPLVT-SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
           P M CAG+++G  D+C+GDSGGPLVT    + W+LIG  SWG  C +  +PGVY  V  +
Sbjct: 349 PGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYY 408

Query: 481 TDWI 484
            +WI
Sbjct: 409 RNWI 412


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  183 bits (465), Expect = 3e-46
 Identities = 94/244 (38%), Positives = 133/244 (54%), Gaps = 7/244 (2%)

Query: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302
           +CG  +     +RI  G  A   AWPWQ SL   N+H CG ++I+  W+VTAAHC +K  
Sbjct: 177 SCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK-Y 235

Query: 303 NNPWHWT-AFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 361
            NP  WT +F   +    M       V + I H  Y S  +  DIA++++   +TF+D +
Sbjct: 236 KNPHQWTVSFGTKINPPLM----KRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDI 291

Query: 362 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLIT 421
           + +CLP      QP     I+G+GA    G++   L  A+V +I    C    VY N I 
Sbjct: 292 RQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIK 351

Query: 422 PAMICAGFLQGNVDSCQGDSGGPLVT-SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF 480
           P M CAG+++G  D+C+GDSGGPLVT    + W+LIG  SWG  C +  +PGVY  V  +
Sbjct: 352 PGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYY 411

Query: 481 TDWI 484
            +WI
Sbjct: 412 RNWI 415


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  181 bits (460), Expect = 1e-45
 Identities = 97/249 (38%), Positives = 131/249 (52%), Gaps = 11/249 (4%)

Query: 254 SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313
           SRIVGGE A  G WPWQ SL + + HVCG S+++  W +TAAHC E  L++P  W    G
Sbjct: 40  SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFG 99

Query: 314 ILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPN 368
            L       S   Y   Y V  +   P Y   +   DIAL+KL  P+T+   ++P+CL  
Sbjct: 100 QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPY-DIALVKLSAPVTYTKHIQPICLQA 158

Query: 369 PGMMLQPEQLCWISGWGATEEKGK--TSEVLNAAKVLLIETQRCNS---RYVYDNLITPA 423
                +    CW++GWG  +E     +   L   +V +I    CN    +Y +   I   
Sbjct: 159 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 218

Query: 424 MICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDW 483
           M+CAG  QG  D+C GDSGGPL  +KN +W+ IG  SWG GC +  RPGVY N+    +W
Sbjct: 219 MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEW 278

Query: 484 IYRQMRADG 492
           I + M   G
Sbjct: 279 IQKLMAQSG 287


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  180 bits (456), Expect = 3e-45
 Identities = 89/242 (36%), Positives = 129/242 (53%), Gaps = 9/242 (3%)

Query: 254 SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313
           +R+VGG+    G WPWQVS+     H CGGS+I  +W++TAAHC         +      
Sbjct: 33  NRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGA 92

Query: 314 ILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMML 373
                   +    +V +V S+P Y     + D+AL++L+ P+ F + + PVCLP+P ++ 
Sbjct: 93  RQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIF 152

Query: 374 QPEQLCWISGWGATEEKGKTSE--VLNAAKVLLIETQRCNSRYVYDN-------LITPAM 424
           +    CW++GWG+  E+    E  +L    V +I+T +CN  Y  D         I   M
Sbjct: 153 ETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDM 212

Query: 425 ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484
           +CAGF +G  D+C+GDSGGPLV      W   G  SWG GCA+  RPGVY  V    +WI
Sbjct: 213 LCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWI 272

Query: 485 YR 486
           +R
Sbjct: 273 HR 274


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  180 bits (456), Expect = 3e-45
 Identities = 95/252 (37%), Positives = 136/252 (53%), Gaps = 14/252 (5%)

Query: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302
           ACG        SRIVGG     G WPWQ S+  +  HVCGGS+I P+W++TAAHC  +  
Sbjct: 27  ACG---QPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRA 83

Query: 303 NNPWHWTAFAGILRQ-SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 361
             P  +    G LR  S         V +V+  P+Y       D+AL++L++P+  +  V
Sbjct: 84  L-PAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARV 142

Query: 362 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSE--VLNAAKVLLIETQRCNSRYVY--- 416
           +PVCLP PG    P   C ++GWG+        E   L   +V L++++ C+  Y     
Sbjct: 143 QPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGAD 202

Query: 417 ----DNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPG 472
               + ++ P  +CAG+ QG+ D+CQGDSGGPL   ++  W L+G  SWG GCA   RPG
Sbjct: 203 VPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPG 262

Query: 473 VYGNVMVFTDWI 484
           VY +V  ++ WI
Sbjct: 263 VYTSVATYSPWI 274


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,025,861
Number of Sequences: 37866
Number of extensions: 1109135
Number of successful extensions: 4243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 3199
Number of HSP's gapped (non-prelim): 593
length of query: 492
length of database: 18,247,518
effective HSP length: 106
effective length of query: 386
effective length of database: 14,233,722
effective search space: 5494216692
effective search space used: 5494216692
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.