Guide to the Human Genome
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Search of human proteins with 20336270

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...   816   0.0  
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...   728   0.0  
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...   374   e-104
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...   372   e-103
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...   369   e-102
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...   368   e-102
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            125   9e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            125   9e-29
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    117   2e-26
gi|32189425 WD repeat domain 69 [Homo sapiens]                        109   5e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            106   4e-23
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         105   9e-23
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         105   9e-23
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         105   9e-23
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           105   9e-23
gi|26665869 WD repeat domain 51B [Homo sapiens]                       105   9e-23
gi|16554629 WD repeat domain 5 [Homo sapiens]                         104   1e-22
gi|16554627 WD repeat domain 5 [Homo sapiens]                         104   1e-22
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   103   3e-22
gi|23199987 WD repeat domain 5B [Homo sapiens]                        103   3e-22
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    103   4e-22
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   103   4e-22
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    102   5e-22
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    102   5e-22
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    102   5e-22
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    99   5e-21
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     99   5e-21
gi|113865883 WD repeat domain 38 [Homo sapiens]                        99   7e-21
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               99   7e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       98   1e-20

>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score =  816 bits (2107), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE 60
           MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE
Sbjct: 1   MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE 60

Query: 61  AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI 120
           AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI
Sbjct: 61  AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI 120

Query: 121 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 180
           VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK
Sbjct: 121 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 180

Query: 181 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 240
           NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV
Sbjct: 181 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 240

Query: 241 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 300
           LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS
Sbjct: 241 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 300

Query: 301 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360
           DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV
Sbjct: 301 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360

Query: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Sbjct: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score =  728 bits (1878), Expect = 0.0
 Identities = 353/353 (100%), Positives = 353/353 (100%)

Query: 43  MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 102
           MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK
Sbjct: 1   MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 60

Query: 103 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 162
           GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI
Sbjct: 61  GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 120

Query: 163 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 222
           ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW
Sbjct: 121 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180

Query: 223 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 282
           DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES
Sbjct: 181 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 240

Query: 283 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 342
           DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA
Sbjct: 241 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 300

Query: 343 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Sbjct: 301 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score =  374 bits (961), Expect = e-104
 Identities = 180/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)

Query: 54  LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
           L  L+ EAE LK ++ + R    D  L Q+   ++ +G+  M+TRRTL+GH  K+  M W
Sbjct: 4   LDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW 63

Query: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
             D R +VS+SQDGK+I+WDS+TTNK HA+ +  +WVM CAYAPSG  +ACGGLDN CS+
Sbjct: 64  GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123

Query: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
           Y L     E      + +A HT YLS C F + D QI+T+SGD TCALWD+E+GQ   +F
Sbjct: 124 YNLK--TREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTF 180

Query: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
            GH  DV+ L LAP      FVSG CD  A +WD+R G C Q F  HESDIN++ ++P+G
Sbjct: 181 TGHTGDVMSLSLAPDT--RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238

Query: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
           +AFA+GSDDATCRL+DLRAD+E+  YS ++II G +SV FS SGRLL AGY+D+  NVWD
Sbjct: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298

Query: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            LK  R  +L GH+NRVS L V+ DG A  +GSWD  L++W
Sbjct: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score =  372 bits (955), Expect = e-103
 Identities = 178/341 (52%), Positives = 237/341 (69%), Gaps = 5/341 (1%)

Query: 54  LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
           L  L+ EAE L+ ++++ R   +D  L Q+   ++++G+  M+TRRTL+GH  K+  M W
Sbjct: 4   LEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHW 63

Query: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
             D R +VS+SQDGK+I+WDS+TTNK HA+ +  +WVM CAYAPSG  +ACGGLDN CS+
Sbjct: 64  GYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123

Query: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
           Y L     E      + +  HT YLS C F + D QI+T+SGD TCALWD+E+ Q   +F
Sbjct: 124 YNLK--TREGNVRVSRELPGHTGYLSCCRFLD-DSQIVTSSGDTTCALWDIETAQQTTTF 180

Query: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
            GH  DV+ L L+P     TFVSG CD  + +WD+R G C Q+F  H SDIN+V ++P+G
Sbjct: 181 TGHSGDVMSLSLSPDM--RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238

Query: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
            AFA+GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+  NVWD
Sbjct: 239 YAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298

Query: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            LKG R  +L GH+NRVS L V+ DG A  +GSWD  LR+W
Sbjct: 299 TLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score =  369 bits (946), Expect = e-102
 Identities = 177/341 (51%), Positives = 232/341 (68%), Gaps = 5/341 (1%)

Query: 54  LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
           L  L+ EAE L+ ++ + R    D  L Q+   ++ +G+  M+TRRTL+GH  K+  M W
Sbjct: 4   LEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHW 63

Query: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
             D R +VS+SQDGK+I+WDS+TTNK HA+ +  +WVM CAYAPSG  +ACGGLDN CS+
Sbjct: 64  GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSI 123

Query: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
           Y L     E      + +  HT YLS C F + D QI+T+SGD TCALWD+E+GQ    F
Sbjct: 124 YSLK--TREGNVRVSRELPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGF 180

Query: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
            GH  DV+ L LAP   G TFVSG CD    +WD+R   C Q F  HESDIN+V ++P+G
Sbjct: 181 AGHSGDVMSLSLAPD--GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNG 238

Query: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
            AF +GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+  N+WD
Sbjct: 239 YAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298

Query: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +KG R  +L GH+NRVS L V+ DG A  +GSWD  L++W
Sbjct: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 49/215 (22%), Positives = 92/215 (42%), Gaps = 7/215 (3%)

Query: 95  MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
           ++  R L GH   + C  +  D + I++SS D    +WD  T  +          VM+ +
Sbjct: 133 VRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLS 191

Query: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
            AP G     G  D    ++    D  ++M   +++   H + ++A +F  +     T S
Sbjct: 192 LAPDGRTFVSGACDASIKLW----DVRDSMC--RQTFIGHESDINAVAFFPNGYAFTTGS 245

Query: 215 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
            D TC L+D+ + Q L  +           +A S +G   ++G  D    +WD   G   
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305

Query: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
                H++ ++ +     G A A+GS D+  ++++
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score =  368 bits (944), Expect = e-102
 Identities = 178/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)

Query: 54  LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
           +  L+ EAE LK ++ + R    DV L ++   +E +G+  M+TRRTL+GH  K+  M W
Sbjct: 4   MEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHW 63

Query: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
             D + +VS+SQDGK+IVWDS+TTNK HA+ +  +WVM CAYAPSG  +ACGGLDN CS+
Sbjct: 64  ATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSI 123

Query: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
           Y L     E      + ++ HT YLS C F + D  I+T+SGD TCALWD+E+GQ    F
Sbjct: 124 YNLK--SREGNVKVSRELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVF 180

Query: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
            GH  D  C+ LA S   N F+SG CD  A +WD+R G C Q F  HESDIN++ ++P+G
Sbjct: 181 VGHTGD--CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNG 238

Query: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
           +A  +GSDDA+CRL+DLRAD+E+  +S ESII G +SV FSLSGRLLFAGY+D+  NVWD
Sbjct: 239 EAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298

Query: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +K  RV IL GH+NRVS L V+ DG A  +GSWD  L++W
Sbjct: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 7/215 (3%)

Query: 95  MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
           +K  R L  H   + C  +  D   IV+SS D    +WD  T  ++          M+ A
Sbjct: 133 VKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLA 191

Query: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
            +P       G  D    ++    D  E     +++   H + ++A  F  +   I T S
Sbjct: 192 VSPDFNLFISGACDASAKLW----DVREGTC--RQTFTGHESDINAICFFPNGEAICTGS 245

Query: 215 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
            D +C L+D+ + Q L  F           +A S +G    +G  D    VWD    + V
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305

Query: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
                H++ ++ +     G A A+GS D+  ++++
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  125 bits (313), Expect = 9e-29
 Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           R  KGH + V C+D+  + +++ S S D  ++VW     ++ +  T     V    ++PS
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G  +A G  D    ++        N+  +      HT  + +  F +     +TAS D T
Sbjct: 73  GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
             +W     + L S   H   V C   +P   G   VS   DK   +WD  S +CV ++ 
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 338
            H   +  V ++PSG   A+   D T +++D+R  R +  Y   S     + + F  SG 
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242

Query: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            L    +D T+ + D+++G  +  L GH+   +T+  S  G  F SG  D  + VW
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 6/121 (4%)

Query: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFGASSVDFS 334
           F+ H   +  V +  +    ASGS D+   ++ ++       ++  K+++    + V+FS
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV----TCVNFS 70

Query: 335 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            SG LL +G  D T+ +W        ++   H   V ++    DG +F + S D T++VW
Sbjct: 71  PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130

Query: 395 A 395
           A
Sbjct: 131 A 131


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  125 bits (313), Expect = 9e-29
 Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           R  KGH + V C+D+  + +++ S S D  ++VW     ++ +  T     V    ++PS
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G  +A G  D    ++        N+  +      HT  + +  F +     +TAS D T
Sbjct: 73  GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
             +W     + L S   H   V C   +P   G   VS   DK   +WD  S +CV ++ 
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 338
            H   +  V ++PSG   A+   D T +++D+R  R +  Y   S     + + F  SG 
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242

Query: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            L    +D T+ + D+++G  +  L GH+   +T+  S  G  F SG  D  + VW
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 6/121 (4%)

Query: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFGASSVDFS 334
           F+ H   +  V +  +    ASGS D+   ++ ++       ++  K+++    + V+FS
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV----TCVNFS 70

Query: 335 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            SG LL +G  D T+ +W        ++   H   V ++    DG +F + S D T++VW
Sbjct: 71  PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130

Query: 395 A 395
           A
Sbjct: 131 A 131


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 4/214 (1%)

Query: 181 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 240
           +E  A++ K +  H+  +   SF+     +L++S DGT  LW +++   L  + GH   V
Sbjct: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588

Query: 241 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 300
                +P   G  FVSGG D+ A +W     Q ++ F  H +D+N  R++P+ +  A+GS
Sbjct: 589 WDTQFSPY--GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646

Query: 301 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360
            D T RL+D+     V I++         S+ FS +GR L  G  D  + +WD+  G  V
Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704

Query: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
             L GH + V +LR S DG    SGS D+T+R+W
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 14/250 (5%)

Query: 62  ESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV 121
           + L+   +     L D E   V ER+  + +      + L GH   V    +  D+  ++
Sbjct: 502 KKLRSVKQASDLSLIDKESDDVLERI--MDEKTASELKILYGHSGPVYGASFSPDRNYLL 559

Query: 122 SSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 179
           SSS+DG V +W   +FT    +       W     ++P G     GG D    ++    D
Sbjct: 560 SSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYGYYFVSGGHDRVARLWAT--D 615

Query: 180 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 239
             + +    +  A H   ++   F  +   + T S D T  LWDV +G  ++ F GH   
Sbjct: 616 HYQPL----RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP 671

Query: 240 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 299
           +  L  +P+  G    +G  D + ++WD+  G  V   + H   + S+R+   G+  ASG
Sbjct: 672 IHSLTFSPN--GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729

Query: 300 SDDATCRLYD 309
           S D T RL+D
Sbjct: 730 SMDNTVRLWD 739



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 47/237 (19%), Positives = 82/237 (34%), Gaps = 53/237 (22%)

Query: 198 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 257
           L+A   T+    I     D T  +W V   +L        +D+  +D             
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV--KQASDLSLIDKESD--------- 521

Query: 258 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRA----- 312
             D    + D ++   ++    H   +    + P  +   S S+D T RL+ L+      
Sbjct: 522 --DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579

Query: 313 --------------------------DREVAIYSKESI----IFGASSVD-----FSLSG 337
                                     DR   +++ +      IF     D     F  + 
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639

Query: 338 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
             +  G  D T+ +WDVL G+ V I  GH+  + +L  SP+G    +G+ D  + +W
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 4/123 (3%)

Query: 274 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI-YSKESIIFGASSVD 332
           V+ +      + SV+           SDD   R+ D +   E+ I Y     ++GAS   
Sbjct: 494 VRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGAS--- 550

Query: 333 FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 392
           FS     L +   D T+ +W +   + +    GH   V   + SP G  F SG  D   R
Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610

Query: 393 VWA 395
           +WA
Sbjct: 611 LWA 613


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  109 bits (272), Expect = 5e-24
 Identities = 69/239 (28%), Positives = 111/239 (46%), Gaps = 11/239 (4%)

Query: 158 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS-DMQILTASGD 216
           SG     G  D  C ++     +  N      ++  H N + A +F N    +I T S D
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELN------TLEGHRNVVYAIAFNNPYGDKIATGSFD 156

Query: 217 GTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA 276
            TC LW VE+G+   +F GH A+++CL   P  T     +G  D  A +WD+++G+ V  
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST--LVATGSMDTTAKLWDIQNGEEVYT 214

Query: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 336
              H ++I S+ +  SGD   +GS D T  ++D    R+V I         ++S ++  S
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274

Query: 337 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
             L+  G  D T  +WD   G  V+ L GH++ +        G    + S D T R+++
Sbjct: 275 --LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331



 Score =  107 bits (267), Expect = 2e-23
 Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 3/206 (1%)

Query: 189 KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS 248
           K +  H   L+  +   S    +T S D TC LWD  SG+ L +  GH   V  +    +
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN-N 144

Query: 249 ETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 308
             G+   +G  DK   +W + +G+C   F  H ++I  + + P     A+GS D T +L+
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204

Query: 309 DLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHEN 368
           D++   EV  Y+         S+ F+ SG  +  G  D+T+ VWD   G +V+IL GH  
Sbjct: 205 DIQNGEEV--YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262

Query: 369 RVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +S+   + D +   +GS D T ++W
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLW 288



 Score =  102 bits (255), Expect = 5e-22
 Identities = 70/297 (23%), Positives = 130/297 (43%), Gaps = 13/297 (4%)

Query: 100 TLKGHGNKVLCMDWCKDKR-RIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           TL+GH N V  + +      +I + S D    +W   T    H        ++  ++ P 
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
              +A G +D    ++ +          +  ++  H+  + + SF  S  +I+T S D T
Sbjct: 189 STLVATGSMDTTAKLWDI------QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
             +WD ++G+ +    GH A++       +   +  ++G  DK   +WD  +G+CV    
Sbjct: 243 VVVWDADTGRKVNILIGHCAEISSASF--NWDCSLILTGSMDKTCKLWDATNGKCVATLT 300

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA-IYSKESIIFGASSVDFSLSG 337
            H+ +I    +  +G   A+ S D T R++     + +A +   E  I   S + F+  G
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI---SKISFNPQG 357

Query: 338 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
             L  G +D T  +WD   G  + +L GH + + +   +  G    +GS D+T R+W
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 61/259 (23%), Positives = 113/259 (43%), Gaps = 14/259 (5%)

Query: 96  KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 155
           K   T +GH  +++C+ +      + + S D    +WD     + + +      +++ ++
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227

Query: 156 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 215
             SG  I  G  D+   V+     +  N+      +  H   +S+ SF      ILT S 
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNI------LIGHCAEISSASFNWDCSLILTGSM 281

Query: 216 DGTCALWDVESGQLLQSFHGHGADVL--CLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 273
           D TC LWD  +G+ + +  GH  ++L  C D     TG    +   D  A ++   + +C
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDY----TGKLIATASADGTARIFSAATRKC 337

Query: 274 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF 333
           +   E HE +I+ + + P G+   +GS D T R++D +  + + +   E       S  F
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--EGHTDEIFSCAF 395

Query: 334 SLSGRLLFAGYNDYTINVW 352
           +  G ++  G  D T  +W
Sbjct: 396 NYKGNIVITGSKDNTCRIW 414


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  106 bits (264), Expect = 4e-23
 Identities = 70/269 (26%), Positives = 115/269 (42%), Gaps = 10/269 (3%)

Query: 126 DGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMA 185
           D  ++VW     ++ +  T     V    ++PSG  +A G  D    ++        N+ 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV------PNVK 55

Query: 186 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 245
            +      HT  + +  F +     +TAS D T  +W     + L S   H   V C   
Sbjct: 56  GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 115

Query: 246 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 305
           +P   G   VS   DK   +WD  S +CV ++  H   +  V ++PSG   A+   D T 
Sbjct: 116 SPD--GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173

Query: 306 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 365
           +++D+R  R +  Y   S     + + F  SG  L    +D T+ + D+++G  +  L G
Sbjct: 174 KVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231

Query: 366 HENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           H+   +T+  S  G  F SG  D  + VW
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 63/250 (25%), Positives = 111/250 (44%), Gaps = 10/250 (4%)

Query: 103 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 162
           GH + V C+++      + S S+D  V +W      +          V +  +   G + 
Sbjct: 21  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80

Query: 163 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 222
                D    V+     K         S++ H N++    F+     I++AS D T  LW
Sbjct: 81  VTASDDKTVKVWATHRQKF------LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134

Query: 223 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 282
           D  S + + S+  HG  V  +D  PS  G    + G D    VWD+R+ + +Q ++ H +
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPS--GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192

Query: 283 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 342
            +N + ++PSG+   + S D+T ++ DL   R   +Y+       A++V FS +G    +
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSRTGEYFAS 250

Query: 343 GYNDYTINVW 352
           G +D  + VW
Sbjct: 251 GGSDEQVMVW 260



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 8/167 (4%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           +L  H N V C  +  D R IVS+S D  V +WD  +    H+      +V    + PSG
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
             IA  G+DN   V+ +   +        +   +H+  ++  SF  S   ++TAS D T 
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHR------LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 266
            + D+  G+LL + HGH        +A S TG  F SGG D++ MVW
Sbjct: 216 KILDLMEGRLLYTLHGHQGP--ATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 22/65 (33%), Positives = 34/65 (52%)

Query: 331 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT 390
           V+FS SG LL +G  D T+ +W        ++   H   V ++    DG +F + S D T
Sbjct: 29  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 88

Query: 391 LRVWA 395
           ++VWA
Sbjct: 89  VKVWA 93


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  105 bits (261), Expect = 9e-23
 Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)

Query: 19  KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78
           +Q+A R    + Q  +  +  A   A           S ++ +++ +  +  E  + H V
Sbjct: 95  RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 154

Query: 79  ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135
             H     ++   +        L+GH ++V    W      + S S D    +W   ++ 
Sbjct: 155 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 214

Query: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184
                  V   C             V +  +  +G  +A G  D    ++     ++ N+
Sbjct: 215 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 270

Query: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244
           A+   ++  H   + A  +      IL+A  D T  +WD  +G+  Q F  H A  L +D
Sbjct: 271 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 327

Query: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
               +   TF S   D    V  +   + V+ F+ H +++N++++ PSG   AS SDD T
Sbjct: 328 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384

Query: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355
            +++ ++  +EV I+  ++      ++ +S +G          +L +   D T+ +WD+ 
Sbjct: 385 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442

Query: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +G     L  H+  V ++  SPDG    SGS+D  + +W
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W +    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D+        K+   HTN ++A  +  S M + + S D T 
Sbjct: 333 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 502

Query: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
           ++  G  + A  +D ++ V D+ K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  105 bits (261), Expect = 9e-23
 Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)

Query: 19  KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78
           +Q+A R    + Q  +  +  A   A           S ++ +++ +  +  E  + H V
Sbjct: 95  RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 154

Query: 79  ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135
             H     ++   +        L+GH ++V    W      + S S D    +W   ++ 
Sbjct: 155 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 214

Query: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184
                  V   C             V +  +  +G  +A G  D    ++     ++ N+
Sbjct: 215 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 270

Query: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244
           A+   ++  H   + A  +      IL+A  D T  +WD  +G+  Q F  H A  L +D
Sbjct: 271 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 327

Query: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
               +   TF S   D    V  +   + V+ F+ H +++N++++ PSG   AS SDD T
Sbjct: 328 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 384

Query: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355
            +++ ++  +EV I+  ++      ++ +S +G          +L +   D T+ +WD+ 
Sbjct: 385 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442

Query: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +G     L  H+  V ++  SPDG    SGS+D  + +W
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W +    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D+        K+   HTN ++A  +  S M + + S D T 
Sbjct: 333 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 502

Query: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
           ++  G  + A  +D ++ V D+ K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  105 bits (261), Expect = 9e-23
 Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)

Query: 19  KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78
           +Q+A R    + Q  +  +  A   A           S ++ +++ +  +  E  + H V
Sbjct: 146 RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 205

Query: 79  ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135
             H     ++   +        L+GH ++V    W      + S S D    +W   ++ 
Sbjct: 206 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 265

Query: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184
                  V   C             V +  +  +G  +A G  D    ++     ++ N+
Sbjct: 266 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 321

Query: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244
           A+   ++  H   + A  +      IL+A  D T  +WD  +G+  Q F  H A  L +D
Sbjct: 322 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 378

Query: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
               +   TF S   D    V  +   + V+ F+ H +++N++++ PSG   AS SDD T
Sbjct: 379 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435

Query: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355
            +++ ++  +EV I+  ++      ++ +S +G          +L +   D T+ +WD+ 
Sbjct: 436 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 493

Query: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +G     L  H+  V ++  SPDG    SGS+D  + +W
Sbjct: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W +    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D+        K+   HTN ++A  +  S M + + S D T 
Sbjct: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553

Query: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
           ++  G  + A  +D ++ V D+ K
Sbjct: 554 WNARGDKVGASASDGSVCVLDLRK 577


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  105 bits (261), Expect = 9e-23
 Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)

Query: 19  KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78
           +Q+A R    + Q  +  +  A   A           S ++ +++ +  +  E  + H V
Sbjct: 146 RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 205

Query: 79  ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135
             H     ++   +        L+GH ++V    W      + S S D    +W   ++ 
Sbjct: 206 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 265

Query: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184
                  V   C             V +  +  +G  +A G  D    ++     ++ N+
Sbjct: 266 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 321

Query: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244
           A+   ++  H   + A  +      IL+A  D T  +WD  +G+  Q F  H A  L +D
Sbjct: 322 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 378

Query: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
               +   TF S   D    V  +   + V+ F+ H +++N++++ PSG   AS SDD T
Sbjct: 379 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435

Query: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355
            +++ ++  +EV I+  ++      ++ +S +G          +L +   D T+ +WD+ 
Sbjct: 436 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 493

Query: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +G     L  H+  V ++  SPDG    SGS+D  + +W
Sbjct: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W +    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D+        K+   HTN ++A  +  S M + + S D T 
Sbjct: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553

Query: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
           ++  G  + A  +D ++ V D+ K
Sbjct: 554 WNARGDKVGASASDGSVCVLDLRK 577


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  105 bits (261), Expect = 9e-23
 Identities = 74/296 (25%), Positives = 126/296 (42%), Gaps = 10/296 (3%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           R  KGH   +  +D   + +++ ++S D  +++W+     + +        V +  ++P 
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G  +A    D    ++        +   K      HT  + +  F+     + TAS D +
Sbjct: 72  GNLLASASRDRTVRLWI------PDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS 125

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
             +W +   + L S + H   V C   +P   G   VS   DK   +WD  + QCV  F 
Sbjct: 126 IKVWSMYRQRFLYSLYRHTHWVRCAKFSPD--GRLIVSCSEDKTIKIWDTTNKQCVNNFS 183

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 338
                 N V + PSG   AS   D T +++D+R ++ +  Y   S   G + + F  SG 
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS--GGVNCISFHPSGN 241

Query: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            L    +D T+ + D+L+G  +  L GH   V T+  S  G  F SG  D  + +W
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 50/170 (29%), Positives = 79/170 (46%), Gaps = 4/170 (2%)

Query: 225 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 284
           E   L + F GH A +  LDL+P+  G    +   D   M+W+ +       +  H+  +
Sbjct: 6   EDPVLERYFKGHKAAITSLDLSPN--GKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63

Query: 285 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 344
            SV++ P G+  AS S D T RL+    D+       ++      SVDFS  G+ L    
Sbjct: 64  TSVQFSPHGNLLASASRDRTVRLWI--PDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121

Query: 345 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            D +I VW + +   +  L+ H + V   + SPDG    S S D T+++W
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)

Query: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 336
           F+ H++ I S+   P+G   A+ S D    L++ +       Y     +   +SV FS  
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV--VTSVQFSPH 71

Query: 337 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           G LL +   D T+ +W   K  + S    H   V ++  S DG    + S D +++VW+
Sbjct: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  104 bits (260), Expect = 1e-22
 Identities = 64/248 (25%), Positives = 117/248 (47%), Gaps = 12/248 (4%)

Query: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 209
           V +  ++P+G  +A    D    ++     K E      K+++ H   +S  ++++    
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNL 101

Query: 210 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 269
           +++AS D T  +WDV SG+ L++  GH   V C +  P    N  VSG  D+   +WD++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESVRIWDVK 159

Query: 270 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 329
           +G+C++    H   +++V +   G    S S D  CR++D  + + +     +      S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVS 218

Query: 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 386
            V FS +G+ + A   D T+ +WD  KG  +    GH+N    +  +     G    SGS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278

Query: 387 WDHTLRVW 394
            D+ + +W
Sbjct: 279 EDNLVYIW 286



 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 55/210 (26%), Positives = 102/210 (48%), Gaps = 5/210 (2%)

Query: 186 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 245
           A K ++A HT  +S+  F+ +   + ++S D    +W    G+  ++  GH   +   D+
Sbjct: 36  ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDV 93

Query: 246 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 305
           A S   N  VS   DK   +WD+ SG+C++  + H + +    + P  +   SGS D + 
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 306 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 365
           R++D++  + +      S     S+V F+  G L+ +   D    +WD   G  +  L  
Sbjct: 154 RIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211

Query: 366 HEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +N  VS ++ SP+G    + + D+TL++W
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 66/302 (21%), Positives = 132/302 (43%), Gaps = 18/302 (5%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL GH   V  + +  +   + SSS D  + +W ++    E  ++     +   A++   
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
             +     D    ++ ++  K        K++  H+NY+  C+F      I++ S D + 
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA-FE 278
            +WDV++G+ L++   H   V  +    +  G+  VS   D    +WD  SGQC++   +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY----SKESIIFGASSVDFS 334
                ++ V++ P+G    + + D T +L+D    + +  Y    +++  IF   SV   
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--- 268

Query: 335 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW--DHTLR 392
             G+ + +G  D  + +W++     V  L GH + V +    P      S +   D T++
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328

Query: 393 VW 394
           +W
Sbjct: 329 LW 330



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 8/216 (3%)

Query: 96  KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 155
           K  +TLKGH N V C ++      IVS S D  V +WD  T      +      V A  +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179

Query: 156 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 215
              G  I     D  C ++     +       K  +      +S   F+ +   IL A+ 
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQ-----CLKTLIDDDNPPVSFVKFSPNGKYILAATL 234

Query: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTF-VSGGCDKKAMVWDMRSGQCV 274
           D T  LWD   G+ L+++ GH  +  C+    S TG  + VSG  D    +W++++ + V
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294

Query: 275 QAFETHESDINSVRYYPSGDAFASGS--DDATCRLY 308
           Q  + H   + S   +P+ +  AS +  +D T +L+
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 59/270 (21%), Positives = 115/270 (42%), Gaps = 12/270 (4%)

Query: 87  VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 146
           ++  G +  K  +T+ GH   +  + W  D   +VS+S D  + +WD  +      +   
Sbjct: 69  IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128

Query: 147 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 206
             +V  C + P    I  G  D    ++ +   K        K++  H++ +SA  F   
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK------CLKTLPAHSDPVSAVHFNRD 182

Query: 207 DMQILTASGDGTCALWDVESGQLLQS-FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 265
              I+++S DG C +WD  SGQ L++        V  +  +P+  G   ++   D    +
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN--GKYILAATLDNTLKL 240

Query: 266 WDMRSGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 322
           WD   G+C++ +  H+++   I +      G    SGS+D    +++L+    V      
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300

Query: 323 SIIFGASSVDFSLSGRLLFAGYNDYTINVW 352
           + +  +++   + +     A  ND TI +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  104 bits (260), Expect = 1e-22
 Identities = 64/248 (25%), Positives = 117/248 (47%), Gaps = 12/248 (4%)

Query: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 209
           V +  ++P+G  +A    D    ++     K E      K+++ H   +S  ++++    
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNL 101

Query: 210 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 269
           +++AS D T  +WDV SG+ L++  GH   V C +  P    N  VSG  D+   +WD++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESVRIWDVK 159

Query: 270 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 329
           +G+C++    H   +++V +   G    S S D  CR++D  + + +     +      S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVS 218

Query: 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 386
            V FS +G+ + A   D T+ +WD  KG  +    GH+N    +  +     G    SGS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278

Query: 387 WDHTLRVW 394
            D+ + +W
Sbjct: 279 EDNLVYIW 286



 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 55/210 (26%), Positives = 102/210 (48%), Gaps = 5/210 (2%)

Query: 186 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 245
           A K ++A HT  +S+  F+ +   + ++S D    +W    G+  ++  GH   +   D+
Sbjct: 36  ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDV 93

Query: 246 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 305
           A S   N  VS   DK   +WD+ SG+C++  + H + +    + P  +   SGS D + 
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 306 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 365
           R++D++  + +      S     S+V F+  G L+ +   D    +WD   G  +  L  
Sbjct: 154 RIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211

Query: 366 HEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +N  VS ++ SP+G    + + D+TL++W
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 66/302 (21%), Positives = 132/302 (43%), Gaps = 18/302 (5%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL GH   V  + +  +   + SSS D  + +W ++    E  ++     +   A++   
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
             +     D    ++ ++  K        K++  H+NY+  C+F      I++ S D + 
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA-FE 278
            +WDV++G+ L++   H   V  +    +  G+  VS   D    +WD  SGQC++   +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY----SKESIIFGASSVDFS 334
                ++ V++ P+G    + + D T +L+D    + +  Y    +++  IF   SV   
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--- 268

Query: 335 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW--DHTLR 392
             G+ + +G  D  + +W++     V  L GH + V +    P      S +   D T++
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328

Query: 393 VW 394
           +W
Sbjct: 329 LW 330



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 8/216 (3%)

Query: 96  KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 155
           K  +TLKGH N V C ++      IVS S D  V +WD  T      +      V A  +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179

Query: 156 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 215
              G  I     D  C ++     +       K  +      +S   F+ +   IL A+ 
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQ-----CLKTLIDDDNPPVSFVKFSPNGKYILAATL 234

Query: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTF-VSGGCDKKAMVWDMRSGQCV 274
           D T  LWD   G+ L+++ GH  +  C+    S TG  + VSG  D    +W++++ + V
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294

Query: 275 QAFETHESDINSVRYYPSGDAFASGS--DDATCRLY 308
           Q  + H   + S   +P+ +  AS +  +D T +L+
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 59/270 (21%), Positives = 115/270 (42%), Gaps = 12/270 (4%)

Query: 87  VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 146
           ++  G +  K  +T+ GH   +  + W  D   +VS+S D  + +WD  +      +   
Sbjct: 69  IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128

Query: 147 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 206
             +V  C + P    I  G  D    ++ +   K        K++  H++ +SA  F   
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK------CLKTLPAHSDPVSAVHFNRD 182

Query: 207 DMQILTASGDGTCALWDVESGQLLQS-FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 265
              I+++S DG C +WD  SGQ L++        V  +  +P+  G   ++   D    +
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN--GKYILAATLDNTLKL 240

Query: 266 WDMRSGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 322
           WD   G+C++ +  H+++   I +      G    SGS+D    +++L+    V      
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300

Query: 323 SIIFGASSVDFSLSGRLLFAGYNDYTINVW 352
           + +  +++   + +     A  ND TI +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  103 bits (257), Expect = 3e-22
 Identities = 77/318 (24%), Positives = 143/318 (44%), Gaps = 37/318 (11%)

Query: 101 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPCTW-------- 149
           L+GH ++V    W      + S S D    +W   ++ T+     V   C          
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224

Query: 150 ---VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 206
              V +  +   G  +A G  D    ++     K+ N+A+   ++  H   + A  +   
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWT----KDGNLAS---TLGQHKGPIFALKWNKK 277

Query: 207 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 266
              IL+A  D T  +WD  +G+  Q F  H A  L +D    ++ NTF S   D    V 
Sbjct: 278 GNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW---QSNNTFASCSTDMCIHVC 334

Query: 267 DMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKES 323
            +   + ++ F+ H +++N++++ P+G+  AS SDD T +++ ++ D    ++  ++KE 
Sbjct: 335 KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEI 394

Query: 324 IIF-------GASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS 376
                     G ++ + +L   +L +   D T+ +WDV +G  +  L  H+  V ++  S
Sbjct: 395 YTIKWSPTGPGTNNPNANL---MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS 451

Query: 377 PDGTAFCSGSWDHTLRVW 394
           PDG    SGS+D  + +W
Sbjct: 452 PDGRYLASGSFDKCVHIW 469



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W K    I+S+  D   I+WD+ T   +          +   +  + 
Sbjct: 261 TLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D+        K+   HTN ++A  +  +   + + S D T 
Sbjct: 321 TFASCS-TDMCIHVCKLGQDR------PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTL 373

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+  G           S   D    +WD+  G 
Sbjct: 374 KIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGI 433

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C+     H+  + SV + P G   ASGS D    +++ +    V  Y     IF    V 
Sbjct: 434 CIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIF---EVC 490

Query: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
           ++ +G  + A  +D ++ V D+ K
Sbjct: 491 WNAAGDKVGASASDGSVCVLDLRK 514



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 53/258 (20%), Positives = 91/258 (35%), Gaps = 64/258 (24%)

Query: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH------------TNY 197
           V  CA+ P    +A G  D+   ++ L+    EN  +    + +                
Sbjct: 172 VFICAWNPVSDLLASGSGDSTARIWNLS----ENSTSGSTQLVLRHCIREGGQDVPSNKD 227

Query: 198 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 257
           +++  + +    + T S DG   +W  + G L  +   H   +  L    ++ GN  +S 
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKW--NKKGNFILSA 284

Query: 258 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 317
           G DK  ++WD  +G+  Q F  H +    V +  S + FAS S D    +  L  DR + 
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343

Query: 318 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 377
            +                                             GH N V+ ++  P
Sbjct: 344 TFQ--------------------------------------------GHTNEVNAIKWDP 359

Query: 378 DGTAFCSGSWDHTLRVWA 395
            G    S S D TL++W+
Sbjct: 360 TGNLLASCSDDMTLKIWS 377



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 45/213 (21%), Positives = 80/213 (37%), Gaps = 42/213 (19%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           +T +GH N+V  + W      + S S D  + +W     N  H +      +    ++P+
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G      G +N                                   N+++ + +AS D T
Sbjct: 403 G-----PGTNN----------------------------------PNANLMLASASFDST 423

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 278
             LWDV+ G  + +   H   V  +  +P   G    SG  DK   +W+ ++G  V ++ 
Sbjct: 424 VRLWDVDRGICIHTLTKHQEPVYSVAFSPD--GRYLASGSFDKCVHIWNTQTGALVHSYR 481

Query: 279 THESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
                I  V +  +GD   + + D +  + DLR
Sbjct: 482 -GTGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513



 Score = 29.3 bits (64), Expect = 6.5
 Identities = 13/37 (35%), Positives = 19/37 (51%)

Query: 358 SRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           ++  +L GHE+ V     +P      SGS D T R+W
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIW 196


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  103 bits (257), Expect = 3e-22
 Identities = 63/248 (25%), Positives = 118/248 (47%), Gaps = 12/248 (4%)

Query: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 209
           V +  ++P+G  +A    D    ++     K E      K++  H   +S  ++++   +
Sbjct: 44  VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE------KTLYGHNLEISDVAWSSDSSR 97

Query: 210 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 269
           +++AS D T  LWDV SG+ L++  GH   V C +  P    N  +SG  D+   +W+++
Sbjct: 98  LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS--NLIISGSFDETVKIWEVK 155

Query: 270 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 329
           +G+C++    H   +++V +  SG    SGS D  CR++D  + + +     +      S
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP-PVS 214

Query: 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 386
            V FS +G+ +     D T+ +WD  +G  +    GH+N    +  +     G    SGS
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274

Query: 387 WDHTLRVW 394
            D+ + +W
Sbjct: 275 EDNLVYIW 282



 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 59/216 (27%), Positives = 109/216 (50%), Gaps = 6/216 (2%)

Query: 180 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 239
           +N N A K   V  HT  +S+  F+ +   + ++S D    +W    G+  ++ +GH  +
Sbjct: 27  ENPNYALKCTLVG-HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85

Query: 240 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 299
           +   D+A S   +  VS   DK   +WD+RSG+C++  + H + +    + P  +   SG
Sbjct: 86  I--SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG 143

Query: 300 SDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSR 359
           S D T ++++++  + +   S  S     S+V F+ SG L+ +G  D    +WD   G  
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHS--DPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC 201

Query: 360 VSILFGHEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +  L   +N  VS ++ SP+G    + + D+TL++W
Sbjct: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 62/266 (23%), Positives = 116/266 (43%), Gaps = 12/266 (4%)

Query: 91  GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWV 150
           G +  K  +TL GH  ++  + W  D  R+VS+S D  + +WD  +      +     +V
Sbjct: 69  GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128

Query: 151 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 210
             C + P    I  G  D    ++ +   K        K+++ H++ +SA  F  S   I
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGK------CLKTLSAHSDPVSAVHFNCSGSLI 182

Query: 211 LTASGDGTCALWDVESGQLLQSF-HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 269
           ++ S DG C +WD  SGQ L++        V  +  +P+  G   ++   D    +WD  
Sbjct: 183 VSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPN--GKYILTATLDNTLKLWDYS 240

Query: 270 SGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF 326
            G+C++ +  H+++   I +      G    SGS+D    +++L+    V      + + 
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300

Query: 327 GASSVDFSLSGRLLFAGYNDYTINVW 352
            +++   + +     A  ND TI +W
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLW 326


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  103 bits (256), Expect = 4e-22
 Identities = 69/237 (29%), Positives = 117/237 (49%), Gaps = 11/237 (4%)

Query: 158 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDG 217
           SG  +A GG D + +++ +      N      S+  HT+ + +      +  I+  S  G
Sbjct: 32  SGRLLATGGDDCRVNLWSI------NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85

Query: 218 TCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF 277
           +  +WD+E+ ++L++  GH A++  LD  P   G    SG  D    +WD+R   CV  +
Sbjct: 86  SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIKLWDIRRKGCVFRY 143

Query: 278 ETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSG 337
             H   +  +R+ P G   AS +DD T +L+DL A + ++ +   +     + V+F  + 
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT--GPVNVVEFHPNE 201

Query: 338 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            LL +G +D TI  WD+ K   VS + G    V ++  +PDG    SG  D +LRV+
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 55/211 (26%), Positives = 99/211 (46%), Gaps = 5/211 (2%)

Query: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCL 243
           A K + +  H + +S+     +  ++L   GD     LW +     + S  GH + V  +
Sbjct: 10  AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV 69

Query: 244 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 303
            L   E     V+G       VWD+ + + ++    H+++I S+ ++P G+  ASGS D 
Sbjct: 70  RLNTPE--ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127

Query: 304 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 363
             +L+D+R  R+  ++           + FS  G+ L +  +D+T+ +WD+  G  +S  
Sbjct: 128 NIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185

Query: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            GH   V+ +   P+     SGS D T+R W
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 9/215 (4%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           +L GH + V  +     +  IV+ SQ G + VWD         +      + +  + P G
Sbjct: 58  SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
             +A G  D    ++ +   + +    + +    H+  +    F+     + +A+ D T 
Sbjct: 118 EFVASGSQDTNIKLWDI---RRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTV 171

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
            LWD+ +G+++  F GH   V  ++  P+E      SG  D+    WD+   Q V   E 
Sbjct: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNE--YLLASGSSDRTIRFWDLEKFQVVSCIEG 229

Query: 280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADR 314
               + SV + P G    SG  D + R+Y    +R
Sbjct: 230 EPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPER 263


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  103 bits (256), Expect = 4e-22
 Identities = 69/225 (30%), Positives = 112/225 (49%), Gaps = 11/225 (4%)

Query: 172 SVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ 231
           SV   + D +E +A     +  HT  ++   +  S   + T   D +  LWD+E+ + + 
Sbjct: 304 SVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359

Query: 232 SFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYP 291
              GH   V   D+A  + G+   +GG D    VWD+R+G+C+   E H  +I  + + P
Sbjct: 360 HQEGHSMGVY--DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417

Query: 292 SGDAFASGSDDATCRLYDLRADREV-AIYSKESIIFGASSVDFS-LSGRLLFAGYNDYTI 349
           +G   A+GS D TC+++DLR  R V  I + ++++ G   V F  + G  L  G  D T 
Sbjct: 418 NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTG---VKFEPIHGNFLLTGAYDNTA 474

Query: 350 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +W     S +  L GHE +V  L +S DG    + S+D T ++W
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 59/203 (29%), Positives = 86/203 (42%), Gaps = 8/203 (3%)

Query: 198 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGN----- 252
           +S C F+ +   + TA   G C LW V    LL +  GH  +V  +   P  T +     
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293

Query: 253 -TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
               S   D    +W + S + V   E H   +  V ++PSG    +   D + RL+DL 
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353

Query: 312 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
           A  E  I  +E    G   + F   G L   G  D    VWD+  G  +  L GH   + 
Sbjct: 354 AQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411

Query: 372 TLRVSPDGTAFCSGSWDHTLRVW 394
            +  SP+G    +GS D+T +VW
Sbjct: 412 GINFSPNGYHIATGSGDNTCKVW 434



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 21/119 (17%)

Query: 155 YAPSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTNSD 207
           ++P+G  IA G  DN C V+ L       T   ++N+    K   +H N+L         
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL--------- 465

Query: 208 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 266
              LT + D T  +W       L++  GH   V+ LD+  S  G    +   D+   +W
Sbjct: 466 ---LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI--SSDGQLIATCSYDRTFKLW 519


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  102 bits (255), Expect = 5e-22
 Identities = 88/385 (22%), Positives = 157/385 (40%), Gaps = 32/385 (8%)

Query: 31  QQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEAL 90
           QQ S  +T A  MA         + S ++  ++ +  +  E    H++  H     ++  
Sbjct: 106 QQASAAATEASAMAKAATMTPAAI-SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGD 164

Query: 91  GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPC 147
            +        L+GH ++V    W      + S S D    +W   ++        V   C
Sbjct: 165 VEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHC 224

Query: 148 TW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTN 196
                        V +  +   G  +A G  D    ++     +N N+A+   ++  H  
Sbjct: 225 IREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT----ENGNLAS---TLGQHKG 277

Query: 197 YLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 256
            + A  +      +L+A  D T  +WD  +G+  Q F  H A  L +D    +   TF S
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW---QNNMTFAS 334

Query: 257 GGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD--- 313
              D    V  +     V+ F+ H +++N++++ PSG   AS SDD T +++ ++ D   
Sbjct: 335 CSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV 394

Query: 314 REVAIYSKESIIFGASSVDFSLSGR----LLFAGYNDYTINVWDVLKGSRVSILFGHENR 369
            ++  +SKE      S    + S      +L +   D T+ +WDV +G     L  H+  
Sbjct: 395 HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEP 454

Query: 370 VSTLRVSPDGTAFCSGSWDHTLRVW 394
           V ++  SPDG    SGS+D  + +W
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W K    ++S+  D   I+WD+ T   +          +   +  + 
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D         K+   HTN ++A  +  S M + + S D T 
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500

Query: 333 FSLSGRLLFAGYNDYTINVWDV 354
           ++  G  + A  +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)

Query: 175 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 227
           P+  D +  +   K +V   H + +  C++      + + SGD T  +W++       S 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217

Query: 228 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
           QL+        GH      DV  LD   +  G     G  D  A +W   +G        
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 338
           H+  I ++++   G+   S   D T  ++D          +K+   F  A ++D      
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329

Query: 339 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           + FA  + D  I+V  +     V    GH N V+ ++  P G    S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  102 bits (255), Expect = 5e-22
 Identities = 88/385 (22%), Positives = 157/385 (40%), Gaps = 32/385 (8%)

Query: 31  QQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEAL 90
           QQ S  +T A  MA         + S ++  ++ +  +  E    H++  H     ++  
Sbjct: 106 QQASAAATEASAMAKAATMTPAAI-SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGD 164

Query: 91  GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPC 147
            +        L+GH ++V    W      + S S D    +W   ++        V   C
Sbjct: 165 VEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHC 224

Query: 148 TW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTN 196
                        V +  +   G  +A G  D    ++     +N N+A+   ++  H  
Sbjct: 225 IREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT----ENGNLAS---TLGQHKG 277

Query: 197 YLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 256
            + A  +      +L+A  D T  +WD  +G+  Q F  H A  L +D    +   TF S
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW---QNNMTFAS 334

Query: 257 GGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD--- 313
              D    V  +     V+ F+ H +++N++++ PSG   AS SDD T +++ ++ D   
Sbjct: 335 CSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV 394

Query: 314 REVAIYSKESIIFGASSVDFSLSGR----LLFAGYNDYTINVWDVLKGSRVSILFGHENR 369
            ++  +SKE      S    + S      +L +   D T+ +WDV +G     L  H+  
Sbjct: 395 HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEP 454

Query: 370 VSTLRVSPDGTAFCSGSWDHTLRVW 394
           V ++  SPDG    SGS+D  + +W
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W K    ++S+  D   I+WD+ T   +          +   +  + 
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D         K+   HTN ++A  +  S M + + S D T 
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500

Query: 333 FSLSGRLLFAGYNDYTINVWDV 354
           ++  G  + A  +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)

Query: 175 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 227
           P+  D +  +   K +V   H + +  C++      + + SGD T  +W++       S 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217

Query: 228 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
           QL+        GH      DV  LD   +  G     G  D  A +W   +G        
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 338
           H+  I ++++   G+   S   D T  ++D          +K+   F  A ++D      
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329

Query: 339 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           + FA  + D  I+V  +     V    GH N V+ ++  P G    S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  102 bits (255), Expect = 5e-22
 Identities = 88/385 (22%), Positives = 157/385 (40%), Gaps = 32/385 (8%)

Query: 31  QQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEAL 90
           QQ S  +T A  MA         + S ++  ++ +  +  E    H++  H     ++  
Sbjct: 106 QQASAAATEASAMAKAATMTPAAI-SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGD 164

Query: 91  GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPC 147
            +        L+GH ++V    W      + S S D    +W   ++        V   C
Sbjct: 165 VEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHC 224

Query: 148 TW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTN 196
                        V +  +   G  +A G  D    ++     +N N+A+   ++  H  
Sbjct: 225 IREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT----ENGNLAS---TLGQHKG 277

Query: 197 YLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 256
            + A  +      +L+A  D T  +WD  +G+  Q F  H A  L +D    +   TF S
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW---QNNMTFAS 334

Query: 257 GGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD--- 313
              D    V  +     V+ F+ H +++N++++ PSG   AS SDD T +++ ++ D   
Sbjct: 335 CSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV 394

Query: 314 REVAIYSKESIIFGASSVDFSLSGR----LLFAGYNDYTINVWDVLKGSRVSILFGHENR 369
            ++  +SKE      S    + S      +L +   D T+ +WDV +G     L  H+  
Sbjct: 395 HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEP 454

Query: 370 VSTLRVSPDGTAFCSGSWDHTLRVW 394
           V ++  SPDG    SGS+D  + +W
Sbjct: 455 VYSVAFSPDGKYLASGSFDKYVHIW 479



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)

Query: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
           TL  H   +  + W K    ++S+  D   I+WD+ T   +          +   +  + 
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330

Query: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
              +C   D    V  L  D         K+   HTN ++A  +  S M + + S D T 
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383

Query: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
            +W ++    +     H  ++  +  +P+    +         S   D    +WD+  G 
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443

Query: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
           C      H+  + SV + P G   ASGS D    +++ ++   V  Y     IF    V 
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500

Query: 333 FSLSGRLLFAGYNDYTINVWDV 354
           ++  G  + A  +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)

Query: 175 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 227
           P+  D +  +   K +V   H + +  C++      + + SGD T  +W++       S 
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217

Query: 228 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
           QL+        GH      DV  LD   +  G     G  D  A +W   +G        
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274

Query: 280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 338
           H+  I ++++   G+   S   D T  ++D          +K+   F  A ++D      
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329

Query: 339 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
           + FA  + D  I+V  +     V    GH N V+ ++  P G    S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 66/225 (29%), Positives = 105/225 (46%), Gaps = 20/225 (8%)

Query: 188 KKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAP 247
           ++++  HT+ +   SF +S   + + S D T  LWD +  + +++ HGH  +V  + + P
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202

Query: 248 SETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL 307
           +  G+  VS   DK   +W++++G CV+ F  H   +  VR    G   AS S+D T R+
Sbjct: 203 N--GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260

Query: 308 Y---------DLRADREV---------AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTI 349
           +         +LR    V         + YS  S   G+ +      G  L +G  D TI
Sbjct: 261 WVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320

Query: 350 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            +WDV  G  +  L GH+N V  +     G    S + D TLRVW
Sbjct: 321 KMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 61/273 (22%), Positives = 104/273 (38%), Gaps = 26/273 (9%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           RTLKGH + V  + +    + + S S D  + +WD         +      V + A  P+
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G  I     D    ++ +            K+   H  ++           I + S D T
Sbjct: 204 GDHIVSASRDKTIKMWEV------QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257

Query: 219 CALWDVESGQLLQSFHGHGADVLCLDLAP------------SET------GNTFVSGGCD 260
             +W V + +       H   V C+  AP            SET      G   +SG  D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317

Query: 261 KKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS 320
           K   +WD+ +G C+     H++ +  V ++  G    S +DD T R++D +  R +   +
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377

Query: 321 KESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
                   +S+DF  +   +  G  D T+ VW+
Sbjct: 378 AHEHF--VTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 54/227 (23%), Positives = 95/227 (41%), Gaps = 16/227 (7%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           RT+ GH + V  +    +   IVS+S+D  + +W+  T       T    WV        
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSV------AMHTNYLSACSFTNSDMQ--- 209
           G  IA    D    V+ +   + +    + + V      A  ++Y S    T S+ +   
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305

Query: 210 -----ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAM 264
                +L+ S D T  +WDV +G  L +  GH  D     +     G   +S   DK   
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH--DNWVRGVLFHSGGKFILSCADDKTLR 363

Query: 265 VWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
           VWD ++ +C++    HE  + S+ ++ +     +GS D T ++++ R
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 43/159 (27%), Positives = 72/159 (45%), Gaps = 8/159 (5%)

Query: 240 VLCLDLAPSETGNTFVSGGC---DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAF 296
           V+ L+   +E    F SGG     +    W  R  +   A   H S +  V ++P     
Sbjct: 65  VMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPE-KYALSGHRSPVTRVIFHPVFSVM 123

Query: 297 ASGSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVL 355
            S S+DAT +++D    D E  +      +     + F  SG+LL +   D TI +WD  
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSV---QDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
               +  + GH++ VS++ + P+G    S S D T+++W
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 58/224 (25%), Positives = 107/224 (47%), Gaps = 4/224 (1%)

Query: 171 CSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLL 230
           C +     D+++N   + K +  H   + +  F      +L+ S D +   WD+ S    
Sbjct: 318 CDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNT 377

Query: 231 QSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYY 290
             + GH   V  LD++P      F SG  D+ A +W       ++ +  H +D++ V+++
Sbjct: 378 VLYQGHAYPVWDLDISPYSL--YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435

Query: 291 PSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTIN 350
           P+ +  A+GS D T RL+  +    V +++         S+ FS +G+ L +   D  + 
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLK 493

Query: 351 VWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           +WD+  G+    L GH + +++L  SPD     S S D+++RVW
Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 12/215 (5%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 156
           + L+GH   V    +  D   ++S S+D  +  WD  SFT    +       W +    +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL--DIS 393

Query: 157 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 216
           P     A G  D    ++  +FD+   +    +  A H   +    F  +   + T S D
Sbjct: 394 PYSLYFASGSHDRTARLW--SFDRTYPL----RIYAGHLADVDCVKFHPNSNYLATGSTD 447

Query: 217 GTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA 276
            T  LW  + G  ++ F GH   VL L  +P+  G    S G D++  +WD+ SG   + 
Sbjct: 448 KTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN--GKYLASAGEDQRLKLWDLASGTLYKE 505

Query: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
              H  +I S+ + P     AS S D + R++D+R
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 19/205 (9%)

Query: 194 HTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCLDLAPSETGN 252
           +T  L   +  + D ++L A  D +C  LW + S +L      H  DV  + LA      
Sbjct: 266 NTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLA------ 317

Query: 253 TFVSGGCD--KKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDL 310
                 CD  ++    D  +G  ++    H   + S R+        S S+D + R +DL
Sbjct: 318 ------CDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371

Query: 311 RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRV 370
            +     +Y   +  +    +D S       +G +D T  +W   +   + I  GH   V
Sbjct: 372 GSFTNTVLYQGHA--YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADV 429

Query: 371 STLRVSPDGTAFCSGSWDHTLRVWA 395
             ++  P+     +GS D T+R+W+
Sbjct: 430 DCVKFHPNSNYLATGSTDKTVRLWS 454



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 29/128 (22%), Positives = 57/128 (44%), Gaps = 6/128 (4%)

Query: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
           R   GH   V C+ +  +   + + S D  V +W +   N     T     V++ A++P+
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479

Query: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
           G  +A  G D +  ++ L            K +  HT+ +++ +F+     I +AS D +
Sbjct: 480 GKYLASAGEDQRLKLWDLA------SGTLYKELRGHTDNITSLTFSPDSGLIASASMDNS 533

Query: 219 CALWDVES 226
             +WD+ +
Sbjct: 534 VRVWDIRN 541


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 64/202 (31%), Positives = 97/202 (48%), Gaps = 4/202 (1%)

Query: 194 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT 253
           HT  +  C F+       +AS D T  LWDV   + L+   GH   V  +  +P      
Sbjct: 62  HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS--RQ 119

Query: 254 FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR-A 312
             SGG DK+ M+WD++SGQ ++    H   I S  + P+ +  A+GS D+T  ++DLR  
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179

Query: 313 DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST 372
              V+  + E      S + +S SG LL +G  D TI++W     S +  L GH   V +
Sbjct: 180 TPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238

Query: 373 LRVSPDGTAFCSGSWDHTLRVW 394
           +  SPD     S  +   ++VW
Sbjct: 239 IAFSPDELWLASAGYSRMVKVW 260



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 62/211 (29%), Positives = 97/211 (45%), Gaps = 12/211 (5%)

Query: 189 KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS 248
           K    H   +++ +F+     +LT S DG    W+  SGQLL    GH   V     +P 
Sbjct: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 249 ETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 308
             G+ F S  CD    +WD+   +C++  + H+  + +V + P     ASG  D    L+
Sbjct: 75  --GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132

Query: 309 DLRADR--EVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD---VLKGSRVSIL 363
           D+++ +   + +  ++SI     S DFS +   L  G  D T+++WD   V        L
Sbjct: 133 DVQSGQMLRLLVGHRDSI----QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL 188

Query: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
            GH   +S L  S  G    SGSWD T+ +W
Sbjct: 189 EGHSANISCLCYSASG-LLASGSWDKTIHIW 218



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 75/292 (25%), Positives = 121/292 (41%), Gaps = 14/292 (4%)

Query: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIA 163
           HG +V    +  D + +++ S+DG V  W++ +      +      V  C ++P G   A
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 164 CGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWD 223
               D  C+V      + + +   K     H   +   SF+    Q+ +   D    LWD
Sbjct: 80  SASCD--CTVRLWDVARAKCLRVLKG----HQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 224 VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS---GQCVQAFETH 280
           V+SGQ+L+   GH   +   D +P  T N   +G  D    +WD+R        QA E H
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSP--TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191

Query: 281 ESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLL 340
            ++I+ + Y  SG   ASGS D T  ++  +      +   +  +    S+ FS     L
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIW--KPTTSSLLIQLKGHVTWVKSIAFSPDELWL 248

Query: 341 FAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 392
            +      + VWD   G  +  L G  +   T   +PDG    SG+ D T R
Sbjct: 249 ASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 48/211 (22%), Positives = 91/211 (43%), Gaps = 6/211 (2%)

Query: 96  KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 155
           K  R LKGH   V  + +  D R++ S   D +V++WD  +      +      + +  +
Sbjct: 96  KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155

Query: 156 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 215
           +P+   +A G  D+   ++ L   +    A   +++  H+  +S   ++ S + + + S 
Sbjct: 156 SPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQALEGHSANISCLCYSASGL-LASGSW 211

Query: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275
           D T  +W   +  LL    GH   V  +  +P E      S G  +   VWD  +G+C++
Sbjct: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL--WLASAGYSRMVKVWDCNTGKCLE 269

Query: 276 AFETHESDINSVRYYPSGDAFASGSDDATCR 306
             +      ++  + P G    SG+ D T R
Sbjct: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)

Query: 274 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF 333
           V+ F  H  ++NS  + P G    +GS+D     ++ R+ +   ++             F
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQ--LLWRLGGHTGPVKFCRF 71

Query: 334 SLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRV 393
           S  G L  +   D T+ +WDV +   + +L GH+  V T+  SPD     SG WD  + +
Sbjct: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131

Query: 394 W 394
           W
Sbjct: 132 W 132


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 85/310 (27%), Positives = 138/310 (44%), Gaps = 26/310 (8%)

Query: 97  TRRTLKGHGNKVLC----MDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMA 152
           T + ++   NKV C    + W  + RR+V+ +  G+  +W+  T N E  +    + V A
Sbjct: 107 TTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRA 166

Query: 153 CAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILT 212
             ++ +   +    L      Y   +  N N     K    H   +   SF+ +D +  T
Sbjct: 167 MTWSHNDMWM----LTADHGGYVKYWQSNMNNV---KMFQAHKEAIREASFSPTDNKFAT 219

Query: 213 ASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV--WDMRS 270
            S DGT  +WD       +   GHGADV C+D  P  T    VSG  D +  +  WD ++
Sbjct: 220 CSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHP--TKGLVVSGSKDSQQPIKFWDPKT 277

Query: 271 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR-ADREVAIY---SKESIIF 326
           GQ +     H++ +  V+   +G+   + S D  C+L+D+R    E+ ++    KE    
Sbjct: 278 GQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKE---- 333

Query: 327 GASSVDFSLSGRLLFA-GYNDYTINVWDVLKGSRV-SILFGHENRVSTLRVSPDGTAFCS 384
            A++V +      LFA G +D ++  W V     V  +   HE  + +L   P G   CS
Sbjct: 334 -ATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCS 392

Query: 385 GSWDHTLRVW 394
           GS DHT + W
Sbjct: 393 GSNDHTSKFW 402



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 7/216 (3%)

Query: 95  MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
           M   +  + H   +    +     +  + S DG V +WD    ++E  +      V    
Sbjct: 192 MNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVD 251

Query: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
           + P+   +  G  D   S  P+ F  +        ++  H N +       +   +LTAS
Sbjct: 252 WHPTKGLVVSGSKD---SQQPIKF-WDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTAS 307

Query: 215 GDGTCALWDVES-GQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 273
            D  C L+D+ +  + LQ F GH  +   +   P   G  F SGG D   + W +   + 
Sbjct: 308 RDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEG-LFASGGSDGSLLFWHVGVEKE 366

Query: 274 VQAFE-THESDINSVRYYPSGDAFASGSDDATCRLY 308
           V   E  HE  I S+ ++P G    SGS+D T + +
Sbjct: 367 VGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 80/307 (26%), Positives = 133/307 (43%), Gaps = 17/307 (5%)

Query: 92  QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP---CT 148
           +F  K +   + H   V C+     K  +VS  +D    +W      K + +        
Sbjct: 339 KFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTD 395

Query: 149 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 208
           W+  C + PSG  +A    D    ++ L   K + +   +     H+  + +C++ +   
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLWDLC--KGDCILTFEG----HSRAVWSCTWHSCGN 449

Query: 209 QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 268
            + ++S D T  +WDV S +   + +GH   V  ++  P    NT ++   DK   +WD 
Sbjct: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS--NTLLTSSADKTLSIWDA 507

Query: 269 RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA 328
           R+G C Q+   H   IN   + P G   AS       +L+D R  + + I S +      
Sbjct: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPG 565

Query: 329 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWD 388
           + V+F  SGR+L     +  I++ D LK   +  L GHEN   T+  S DG    SG  D
Sbjct: 566 NEVNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSD 624

Query: 389 HTLRVWA 395
            T+R W+
Sbjct: 625 GTVRTWS 631



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 28/274 (10%)

Query: 139 KEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA------ 192
           KE+A   P    +  A   + C     G + K S +P+    N N+   K+S++      
Sbjct: 284 KENAPEGPTQKGLREAREQNKCKTKMKG-NTKDSEFPIDMQPNPNLNVSKESLSPAKFDY 342

Query: 193 -------MHTNYLSACSFTNSDMQILTASGDGTCALWDV----ESGQLLQSFHGHGADVL 241
                  +H   +S C        IL + G+    LW V    +   LL  F GH  D L
Sbjct: 343 KLKNIFRLHELPVS-CVSMQPHKDILVSCGEDR--LWKVLGLPKCNVLLTGF-GH-TDWL 397

Query: 242 CLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSD 301
             D     +G+   +   D    +WD+  G C+  FE H   + S  ++  G+  AS S 
Sbjct: 398 S-DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456

Query: 302 DATCRLYDLRADR-EVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360
           D T +++D+ ++R    +Y     +   +S++F      L     D T+++WD   G   
Sbjct: 457 DKTSKIWDVNSERCRCTLYGHTDSV---NSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513

Query: 361 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
             L+GH + ++     P G    S       ++W
Sbjct: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW 547


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.132    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,826,584
Number of Sequences: 37866
Number of extensions: 636118
Number of successful extensions: 5047
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1989
Number of HSP's gapped (non-prelim): 1473
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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