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Search of human proteins with 20336244
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 1318 0.0
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 515 e-146
gi|4505579 furin preproprotein [Homo sapiens] 515 e-146
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 504 e-143
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 504 e-143
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 504 e-143
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 504 e-143
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 485 e-137
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 484 e-136
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 484 e-136
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 484 e-136
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 477 e-134
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 377 e-104
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 372 e-103
gi|4506775 membrane-bound transcription factor site-1 protease p... 36 0.095
gi|5803167 splicing factor 3a, subunit 3 [Homo sapiens] 36 0.12
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 33 1.1
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 32 1.4
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 32 1.4
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 32 1.4
gi|16933557 dachsous 1 precursor [Homo sapiens] 32 1.8
gi|239754979 PREDICTED: hypothetical protein [Homo sapiens] 32 2.3
gi|62739166 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 i... 30 6.8
gi|33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 i... 30 6.8
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro... 30 6.8
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 1318 bits (3412), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL 60
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
Sbjct: 1 MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL 60
Query: 61 PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN 120
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
Sbjct: 61 PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN 120
Query: 121 MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN 180
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
Sbjct: 121 MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN 180
Query: 181 YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM 240
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
Sbjct: 181 YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM 240
Query: 241 LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK 300
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
Sbjct: 241 LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK 300
Query: 301 GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK 360
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
Sbjct: 301 GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK 360
Query: 361 RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN 420
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
Sbjct: 361 RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN 420
Query: 421 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP 480
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
Sbjct: 421 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP 480
Query: 481 STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP 540
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
Sbjct: 481 STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP 540
Query: 541 RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI 600
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
Sbjct: 541 RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI 600
Query: 601 DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN 638
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
Sbjct: 601 DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN 638
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 515 bits (1327), Expect = e-146
Identities = 282/620 (45%), Positives = 394/620 (63%), Gaps = 15/620 (2%)
Query: 17 FCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLA 75
+C + A A+R F N + E+ GG + A +A E G+ + ++ E Y F H
Sbjct: 19 WCALNSAKAKRQ-FVNEWAAEI-PGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHP 76
Query: 76 KAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINT 135
+ RR + H ++L D RV A QQ +R KR + +++ NDP++ +QWYL +T
Sbjct: 77 RRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL-FNDPMWNQQWYLQDT 135
Query: 136 GQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPY 195
P LDL+V W+ G TGKGV I ++DDG+++ H D+ +NY+ EASYDF+ ND
Sbjct: 136 RMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHD 195
Query: 196 PYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSI 255
P+PRY N HGTRCAGE++ ANN+ CGVGVAYNSKV GIRMLD +TD IEASSI
Sbjct: 196 PFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSI 254
Query: 256 SHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSY- 314
P +DIYSASWGP D+GKTV+GP L +A GV +GR GKGSI+VWASG+GG
Sbjct: 255 GFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQG 314
Query: 315 DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYG 374
D+C+CDGY S++TISI+SA G + Y E CSSTLA+++S+G + + + DL+
Sbjct: 315 DNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQR--ITSADLHN 372
Query: 375 NCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGV 434
+CT H+GTSA+AP AAG+FALALEAN LTWRDMQHL V TS+ + L + W++NG
Sbjct: 373 DCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANN-PGWKKNGA 431
Query: 435 GLEFNHLFGYGVLDAGAMVKMA--KDWKTVPERFHC-VGGSVQDPEKIPSTGKLVLTLTT 491
GL N FG+G+L+A A+V +A + W++VPE+ C V + +P + + G++++ + T
Sbjct: 432 GLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPT 491
Query: 492 DACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDK 551
ACEG+EN ++ LEHVQ T+ +RRGDL++ +TS GT ++LL+ R R D S GF
Sbjct: 492 RACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERER-DTSPNGFKN 550
Query: 552 WPFMTTHTWGEDARGTWTLEL-GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQS- 609
W FM+ HTWGE+ GTWTL + G +G + W L+LHGT S P + R Y S
Sbjct: 551 WDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSY 610
Query: 610 KLAMSKKEELEEELDEAVER 629
+ + +E+ +D E+
Sbjct: 611 NTVQNDRRGVEKMVDPGEEQ 630
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 515 bits (1326), Expect = e-146
Identities = 282/585 (48%), Positives = 368/585 (62%), Gaps = 24/585 (4%)
Query: 11 AAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFY 70
AA G L + A ++ VFTN + V + GG A VA +HGF F + YHF+
Sbjct: 12 AATGTLVLLAADAQGQK-VFTNTWAVRI-PGGPAVANSVARKHGFLNLGQIFGD-YYHFW 68
Query: 71 HNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQW 130
H G+ K +L+R+P+V+ QQ K+R RD+ + DP F +QW
Sbjct: 69 HRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVA---KRRTKRDVYQ---EPTDPKFPQQW 122
Query: 131 YLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFS 190
YL G DLNV AW GYTG G+ + I+DDGI+ HPDLA NY+ AS+D +
Sbjct: 123 YL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVN 176
Query: 191 SNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDII 250
DP P PRYT N HGTRCAGEV+A ANN +CGVGVAYN+++ G+RMLD +TD +
Sbjct: 177 DQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGE-VTDAV 235
Query: 251 EASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGD 310
EA S+ P I IYSASWGP D+GKTVDGP L +A GV++GRGG GSI+VWASG+
Sbjct: 236 EARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGN 295
Query: 311 GG-SYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVAT 369
GG +D CNCDGY +S++T+SI+SA G Y E+CSSTLA+T+S+G + E + T
Sbjct: 296 GGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN--EKQIVT 353
Query: 370 TDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQW 429
TDL CT H+GTSA+AP AAG+ AL LEAN LTWRDMQHL V TSK H + W
Sbjct: 354 TDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK--PAHLNANDW 411
Query: 430 RRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTL 489
NGVG + +H +GYG+LDAGAMV +A++W TV + C+ + +P+ I +L +
Sbjct: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGK--RLEVRK 469
Query: 490 TTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGF 549
T AC G+ N + LEH QA +T++ RRGDL I++ SPMGT+S LL+ RP D S GF
Sbjct: 470 TVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPH-DYSADGF 528
Query: 550 DKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
+ W FMTTH+W ED G W LE+ A G L ++TL+L+GT
Sbjct: 529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGT 573
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 504 bits (1298), Expect = e-143
Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
WGE A G WTLE+ V + ++G LKEW+L+L+GT PY +S++
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
Query: 616 KEELE 620
ELE
Sbjct: 654 APELE 658
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 504 bits (1298), Expect = e-143
Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
WGE A G WTLE+ V + ++G LKEW+L+L+GT PY +S++
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
Query: 616 KEELE 620
ELE
Sbjct: 654 APELE 658
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 504 bits (1298), Expect = e-143
Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
WGE A G WTLE+ V + ++G LKEW+L+L+GT PY +S++
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
Query: 616 KEELE 620
ELE
Sbjct: 654 APELE 658
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 504 bits (1298), Expect = e-143
Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
WGE A G WTLE+ V + ++G LKEW+L+L+GT PY +S++
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
Query: 616 KEELE 620
ELE
Sbjct: 654 APELE 658
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 485 bits (1249), Expect = e-137
Identities = 262/576 (45%), Positives = 364/576 (63%), Gaps = 26/576 (4%)
Query: 22 FASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLY-HFYHNGLAKAKRR 80
+A P++ + + V++ +G + R +A + GF F +G Y H H G+ +
Sbjct: 26 WAPVRAPIYVSSWAVQVSQGNREVER-LARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLT 84
Query: 81 RSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADG 140
H+ L+++P+V+ QQ R KR + DP F+KQWY+ + Q D
Sbjct: 85 PHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV-------VVPTDPWFSKQWYMNSEAQPD- 136
Query: 141 TPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRY 200
L++ +AW G +G+G+ + ++DDGI+ HPDL +NY+ ASYDF+ DP P PRY
Sbjct: 137 -----LSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRY 191
Query: 201 TDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQ 260
T N HGTRCAGEV+A ANN CGVGVA+N+++ G+RMLD +TD+IEA S+S PQ
Sbjct: 192 TPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGT-ITDVIEAQSLSLQPQ 250
Query: 261 LIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNC 319
I IYSASWGP D+G+TVDGP LT +A GV KGRGG G++++WASG+GG YD+CNC
Sbjct: 251 HIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNC 310
Query: 320 DGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLR 379
DGY +S+ T+S+ S GR Y E+C+STL +T+S+G +P+ + TTDL+ CT +
Sbjct: 311 DGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQ--IVTTDLHHGCTDQ 368
Query: 380 HSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFN 439
H+GTSA+AP AAG+ ALALEAN LTWRDMQHL V SK H + WR NGVG + +
Sbjct: 369 HTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASK--PAHLQAEDWRTNGVGRQVS 426
Query: 440 HLFGYGVLDAGAMVKMAKDW-KTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKE 498
H +GYG+LDAG +V A+ W T P+R V VQ P + + AC G
Sbjct: 427 HHYGYGLLDAGLLVDTARTWLPTQPQRKCAV--RVQS-RPTPILPLIYIRENVSACAGLH 483
Query: 499 NFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTH 558
N +R LEHVQA +T++ +RRGDL I++TSPMGT+S L++ RP D ++ G++ W FM+TH
Sbjct: 484 NSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTE-GYNNWVFMSTH 542
Query: 559 TWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
W E+ +G WTL L G G L +TL+L+GT
Sbjct: 543 FWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGT 578
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 484 bits (1245), Expect = e-136
Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL 572
WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 484 bits (1245), Expect = e-136
Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL 572
WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 484 bits (1245), Expect = e-136
Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
+G+G++DA A+V AK W VP + CV S + P IP L T T AC E +
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
V YLEHV +++ RRGDL I + SP GTKS LL++R D S GF W FMT H
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
Query: 560 WGEDARGTWTLEL 572
WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 477 bits (1228), Expect = e-134
Identities = 262/578 (45%), Positives = 352/578 (60%), Gaps = 15/578 (2%)
Query: 29 VFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQ 87
V+TNH+ V++ GG +A ++A+++GF + ++ + YHFYH+ K S
Sbjct: 34 VYTNHWAVKI-AGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHS 92
Query: 88 QLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLN 147
+ +P+V+ QQ R KR Y NDP + WY+ + D+N
Sbjct: 93 FISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMN 151
Query: 148 VAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNS 207
+ AW+ GYTGK + + I+DDGI+ HPDL NY+A AS D + ND P PRY N
Sbjct: 152 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK 211
Query: 208 HGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSA 267
HGTRCAGEV+AAANN+ C VG+A+N+K+ G+RMLD +TD++EA S+S PQ + IYSA
Sbjct: 212 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGD-VTDMVEAKSVSFNPQHVHIYSA 270
Query: 268 SWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSM 326
SWGP D+GKTVDGP LT QA +GV GR G GS++VWASG+GG S D C+CDGY +S+
Sbjct: 271 SWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSI 330
Query: 327 WTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAA 386
+TISI+S G+ Y E CSSTLA+T+S+G + + + TTDL CT H+GTSA+
Sbjct: 331 YTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKK--IITTDLRQRCTDNHTGTSAS 388
Query: 387 APEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGV 446
AP AAG+ ALALEAN LTWRD+QH+ V TS+ L+ + W+ N G + +HL+G+G+
Sbjct: 389 APMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLN--ANDWKTNAAGFKVSHLYGFGL 446
Query: 447 LDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKEN-FVRYLE 505
+DA AMV A+ W TVP + CV + + + I + C N V YLE
Sbjct: 447 MDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLE 506
Query: 506 HVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDAR 565
HV IT+ RRGDL I +TSP GT+S LL+ R D S GF W FMT H WGE A
Sbjct: 507 HVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR-LFDHSMEGFKNWEFMTIHCWGERAA 565
Query: 566 GTWTLELGFVGSAPQK----GVLKEWTLMLHGTQSAPY 599
G W LE+ S + G LKEW+L+L+GT PY
Sbjct: 566 GDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY 603
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 377 bits (967), Expect = e-104
Identities = 206/481 (42%), Positives = 290/481 (60%), Gaps = 13/481 (2%)
Query: 119 INMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLA 178
++ NDP + +QW+L N +PG D+NV WE TG+GVT+ ++DDG+++ D+A
Sbjct: 143 VHFNDPKYPQQWHLNNRR----SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIA 198
Query: 179 SNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGI 238
NY+ E SYD +SNDP P P + N HGTRCAGE++A NN+ C VGVAY S++AGI
Sbjct: 199 PNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGI 258
Query: 239 RMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRG 298
R+LD P +TD +EA + + Q+ DIYS SWGP D+GKTVDGP +L A+ GV GR
Sbjct: 259 RVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQ 317
Query: 299 GKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSN 357
G GSI+V ASG+GG + D+CN DGYA+S++T++I + +GR Y E C+S LA TFS
Sbjct: 318 GFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSG 377
Query: 358 GRKRNPEAGVATTDLY--GNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVL 415
G K DL CT H+GTSAAAP AAG+ AL L+ LTWRD+QH+ V
Sbjct: 378 GDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVF 437
Query: 416 TSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
T+ R + D +W N G +H G+G+L+A +V AK W +VP V +++
Sbjct: 438 TATRYE--DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKE 495
Query: 476 PEKIP-STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI 534
+ IP S L + + + + ++ LEHV +++ RRG L + + P G S+
Sbjct: 496 NKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSL 555
Query: 535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHG 593
+ + R D D GF+ W F T WGE ARGT+ L + VG Q G+L++W L L+G
Sbjct: 556 IGAPRSMDSDPN-GFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
Query: 594 T 594
+
Sbjct: 615 S 615
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 372 bits (956), Expect = e-103
Identities = 205/415 (49%), Positives = 266/415 (64%), Gaps = 10/415 (2%)
Query: 23 ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
A RPV+TNH+ V++ GG +A +VAA HG+ + ++ E YHFYH+ K
Sbjct: 63 APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
Query: 82 SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
S L DP+VK QQE R KR R + + NDP+++ WYL + G +
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
++NV AW+ GYTGK V + I+DDGI+ HPDLA NY++ ASYD + ND P PRY
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD +TD++EA S+ P
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
IDIYSASWGP D+GKTVDGP L QA G+ KGR G GSI+VWASG+GG D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
GY +S++TIS++SA +G Y E C+STLA+T+S+G E + TTDL CT H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVG 435
+GTS +AP AG+ ALALEAN LTWRD+QHL V TS+ H + W+ NG G
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAG 469
>gi|4506775 membrane-bound transcription factor site-1 protease
preproprotein [Homo sapiens]
Length = 1052
Score = 36.2 bits (82), Expect = 0.095
Identities = 63/256 (24%), Positives = 101/256 (39%), Gaps = 43/256 (16%)
Query: 152 WELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTR 211
W++GYTG V + + D G+ HP N + ++++ R DD HGT
Sbjct: 203 WQMGYTGANVRVAVFDTGLSEKHPHFK---NVKERTNWTNE------RTLDDGL-GHGTF 252
Query: 212 CAGEVSAAANNNICGVGVAYNSKVAGIRMLDQ---PFMTDIIEASSISHMPQLIDIYSAS 268
AG +++ G A ++++ R+ + + ++A + + + + ID+ + S
Sbjct: 253 VAGVIASMRECQ----GFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK-IDVLNLS 307
Query: 269 WGPTD--NGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASG-DGGSYDDCNCDGYASS 325
G D + VD ELT I V A G DG Y N A
Sbjct: 308 IGGPDFMDHPFVDKVWELT-------------ANNVIMVSAIGNDGPLYGTLN--NPADQ 352
Query: 326 MWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPE-----AGVATTDLYGNCTLRH 380
M I + + A + +T GR + P+ AGV + + G C
Sbjct: 353 MDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMK-PDIVTYGAGVRGSGVKGGCRAL- 410
Query: 381 SGTSAAAPEAAGVFAL 396
SGTS A+P AG L
Sbjct: 411 SGTSVASPVVAGAVTL 426
>gi|5803167 splicing factor 3a, subunit 3 [Homo sapiens]
Length = 501
Score = 35.8 bits (81), Expect = 0.12
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 5/76 (6%)
Query: 153 ELGYTGKGVTIGIMDDGIDY----LHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSH 208
E+ Y K + +G I Y LH L NYN E +++ P + R+ +W ++H
Sbjct: 375 EIIYNPKNLPLGWDGKPIPYWLYKLH-GLNINYNCEICGNYTYRGPKAFQRHFAEWRHAH 433
Query: 209 GTRCAGEVSAAANNNI 224
G RC G + A N+
Sbjct: 434 GMRCLGIPNTAHFANV 449
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 32.7 bits (73), Expect = 1.1
Identities = 30/123 (24%), Positives = 49/123 (39%), Gaps = 8/123 (6%)
Query: 83 LHHKQQLERDPRVKMALQQEGFDRKK-RGYRDINEI-----DINMNDPLFTKQWYLINTG 136
+H ++L+R+ + L+ + DRK R +E DIN N+P FTK Y +
Sbjct: 110 IHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVP 169
Query: 137 QAD--GTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDP 194
+ GT + + +A + Y + + G Y D S A D S +
Sbjct: 170 EMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENR 229
Query: 195 YPY 197
Y
Sbjct: 230 EQY 232
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 32.3 bits (72), Expect = 1.4
Identities = 18/95 (18%), Positives = 41/95 (43%)
Query: 368 ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
ATT ++ N + S + + + + + + N+ TW+ + H T +K +++++
Sbjct: 1889 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 1948
Query: 428 QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
GVG + N G + + A+ W +
Sbjct: 1949 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 1983
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 32.3 bits (72), Expect = 1.4
Identities = 18/95 (18%), Positives = 41/95 (43%)
Query: 368 ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
ATT ++ N + S + + + + + + N+ TW+ + H T +K +++++
Sbjct: 130 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 189
Query: 428 QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
GVG + N G + + A+ W +
Sbjct: 190 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 224
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 32.3 bits (72), Expect = 1.4
Identities = 18/95 (18%), Positives = 41/95 (43%)
Query: 368 ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
ATT ++ N + S + + + + + + N+ TW+ + H T +K +++++
Sbjct: 1885 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 1944
Query: 428 QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
GVG + N G + + A+ W +
Sbjct: 1945 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 1979
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 32.0 bits (71), Expect = 1.8
Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 7/71 (9%)
Query: 88 QLERDPRVKMALQQEGFD-----RKKRGYRDINEIDINMNDPLFTKQWY--LINTGQADG 140
+L+R+ R LQ E +D R+ + D+ +DIN + P F + Y +++ A G
Sbjct: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271
Query: 141 TPGLDLNVAEA 151
+P L + ++A
Sbjct: 272 SPVLQVFASDA 282
>gi|239754979 PREDICTED: hypothetical protein [Homo sapiens]
Length = 780
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/66 (28%), Positives = 27/66 (40%), Gaps = 1/66 (1%)
Query: 342 LYDESCSSTLASTFSN-GRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEA 400
LY S S+TL P + L +CT + + AAP A V ++ E
Sbjct: 397 LYFSSSSATLVEAAERTASPPGPSVSLTVCSLCSSCTFSVAAAAPAAPSACDVLKMSEER 456
Query: 401 NLGLTW 406
+L L W
Sbjct: 457 SLELRW 462
>gi|62739166 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
isoform b precursor [Homo sapiens]
Length = 737
Score = 30.0 bits (66), Expect = 6.8
Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 468 CVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFV---RYLEHVQAVITVNATRRGDLNIN 524
C+G + P IP+ LV+T+ T +G F+ +Y + V+ RG IN
Sbjct: 23 CLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGIN 82
>gi|33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
isoform a precursor [Homo sapiens]
Length = 758
Score = 30.0 bits (66), Expect = 6.8
Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 468 CVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFV---RYLEHVQAVITVNATRRGDLNIN 524
C+G + P IP+ LV+T+ T +G F+ +Y + V+ RG IN
Sbjct: 23 CLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGIN 82
>gi|31317307 proprotein convertase subtilisin/kexin type 9
preproprotein [Homo sapiens]
Length = 692
Score = 30.0 bits (66), Expect = 6.8
Identities = 15/49 (30%), Positives = 27/49 (55%)
Query: 376 CTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHD 424
C + SGTS AA AG+ A+ L A LT +++ + S ++ +++
Sbjct: 378 CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINE 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,123,038
Number of Sequences: 37866
Number of extensions: 1139257
Number of successful extensions: 2818
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2681
Number of HSP's gapped (non-prelim): 30
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.