Guide to the Human Genome
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Search of human proteins with 20336244

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
         (638 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ...  1318   0.0  
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro...   515   e-146
gi|4505579 furin preproprotein [Homo sapiens]                         515   e-146
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...   504   e-143
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...   504   e-143
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...   504   e-143
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...   504   e-143
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ...   485   e-137
gi|20336188 paired basic amino acid cleaving system 4 isoform e ...   484   e-136
gi|27894285 paired basic amino acid cleaving system 4 isoform f ...   484   e-136
gi|20336190 paired basic amino acid cleaving system 4 isoform d ...   484   e-136
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...   477   e-134
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro...   377   e-104
gi|20336186 paired basic amino acid cleaving system 4 isoform c ...   372   e-103
gi|4506775 membrane-bound transcription factor site-1 protease p...    36   0.095
gi|5803167 splicing factor 3a, subunit 3 [Homo sapiens]                36   0.12 
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]            33   1.1  
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]        32   1.4  
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]        32   1.4  
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]        32   1.4  
gi|16933557 dachsous 1 precursor [Homo sapiens]                        32   1.8  
gi|239754979 PREDICTED: hypothetical protein [Homo sapiens]            32   2.3  
gi|62739166 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 i...    30   6.8  
gi|33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 i...    30   6.8  
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro...    30   6.8  

>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
           sapiens]
          Length = 638

 Score = 1318 bits (3412), Expect = 0.0
 Identities = 638/638 (100%), Positives = 638/638 (100%)

Query: 1   MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL 60
           MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
Sbjct: 1   MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL 60

Query: 61  PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN 120
           PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
Sbjct: 61  PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN 120

Query: 121 MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN 180
           MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
Sbjct: 121 MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN 180

Query: 181 YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM 240
           YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
Sbjct: 181 YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM 240

Query: 241 LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK 300
           LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
Sbjct: 241 LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK 300

Query: 301 GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK 360
           GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
Sbjct: 301 GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK 360

Query: 361 RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN 420
           RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
Sbjct: 361 RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN 420

Query: 421 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP 480
           QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
Sbjct: 421 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP 480

Query: 481 STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP 540
           STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
Sbjct: 481 STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP 540

Query: 541 RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI 600
           RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
Sbjct: 541 RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI 600

Query: 601 DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN 638
           DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
Sbjct: 601 DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN 638


>gi|20336242 proprotein convertase subtilisin/kexin type 1
           preproprotein [Homo sapiens]
          Length = 753

 Score =  515 bits (1327), Expect = e-146
 Identities = 282/620 (45%), Positives = 394/620 (63%), Gaps = 15/620 (2%)

Query: 17  FCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVR-KLPFAEGLYHFYHNGLA 75
           +C +  A A+R  F N +  E+  GG + A  +A E G+ +  ++   E  Y F H    
Sbjct: 19  WCALNSAKAKRQ-FVNEWAAEI-PGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHP 76

Query: 76  KAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINT 135
           +  RR + H  ++L  D RV  A QQ   +R KR     + +++  NDP++ +QWYL +T
Sbjct: 77  RRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL-FNDPMWNQQWYLQDT 135

Query: 136 GQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPY 195
                 P LDL+V   W+ G TGKGV I ++DDG+++ H D+ +NY+ EASYDF+ ND  
Sbjct: 136 RMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHD 195

Query: 196 PYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSI 255
           P+PRY     N HGTRCAGE++  ANN+ CGVGVAYNSKV GIRMLD   +TD IEASSI
Sbjct: 196 PFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLD-GIVTDAIEASSI 254

Query: 256 SHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSY- 314
              P  +DIYSASWGP D+GKTV+GP  L  +A   GV +GR GKGSI+VWASG+GG   
Sbjct: 255 GFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQG 314

Query: 315 DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYG 374
           D+C+CDGY  S++TISI+SA   G +  Y E CSSTLA+++S+G   +    + + DL+ 
Sbjct: 315 DNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQR--ITSADLHN 372

Query: 375 NCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGV 434
           +CT  H+GTSA+AP AAG+FALALEAN  LTWRDMQHL V TS+ + L +    W++NG 
Sbjct: 373 DCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANN-PGWKKNGA 431

Query: 435 GLEFNHLFGYGVLDAGAMVKMA--KDWKTVPERFHC-VGGSVQDPEKIPSTGKLVLTLTT 491
           GL  N  FG+G+L+A A+V +A  + W++VPE+  C V  +  +P  + + G++++ + T
Sbjct: 432 GLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPT 491

Query: 492 DACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDK 551
            ACEG+EN ++ LEHVQ   T+  +RRGDL++ +TS  GT ++LL+ R R D S  GF  
Sbjct: 492 RACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERER-DTSPNGFKN 550

Query: 552 WPFMTTHTWGEDARGTWTLEL-GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQS- 609
           W FM+ HTWGE+  GTWTL +    G    +G +  W L+LHGT S P   +  R Y S 
Sbjct: 551 WDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSY 610

Query: 610 KLAMSKKEELEEELDEAVER 629
               + +  +E+ +D   E+
Sbjct: 611 NTVQNDRRGVEKMVDPGEEQ 630


>gi|4505579 furin preproprotein [Homo sapiens]
          Length = 794

 Score =  515 bits (1326), Expect = e-146
 Identities = 282/585 (48%), Positives = 368/585 (62%), Gaps = 24/585 (4%)

Query: 11  AAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFY 70
           AA G L  +   A  ++ VFTN + V +  GG   A  VA +HGF      F +  YHF+
Sbjct: 12  AATGTLVLLAADAQGQK-VFTNTWAVRI-PGGPAVANSVARKHGFLNLGQIFGD-YYHFW 68

Query: 71  HNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQW 130
           H G+ K           +L+R+P+V+   QQ     K+R  RD+ +      DP F +QW
Sbjct: 69  HRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVA---KRRTKRDVYQ---EPTDPKFPQQW 122

Query: 131 YLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFS 190
           YL       G    DLNV  AW  GYTG G+ + I+DDGI+  HPDLA NY+  AS+D +
Sbjct: 123 YL------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVN 176

Query: 191 SNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDII 250
             DP P PRYT    N HGTRCAGEV+A ANN +CGVGVAYN+++ G+RMLD   +TD +
Sbjct: 177 DQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGE-VTDAV 235

Query: 251 EASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGD 310
           EA S+   P  I IYSASWGP D+GKTVDGP  L  +A   GV++GRGG GSI+VWASG+
Sbjct: 236 EARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGN 295

Query: 311 GG-SYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVAT 369
           GG  +D CNCDGY +S++T+SI+SA   G    Y E+CSSTLA+T+S+G +   E  + T
Sbjct: 296 GGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN--EKQIVT 353

Query: 370 TDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQW 429
           TDL   CT  H+GTSA+AP AAG+ AL LEAN  LTWRDMQHL V TSK    H   + W
Sbjct: 354 TDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK--PAHLNANDW 411

Query: 430 RRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTL 489
             NGVG + +H +GYG+LDAGAMV +A++W TV  +  C+   + +P+ I    +L +  
Sbjct: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGK--RLEVRK 469

Query: 490 TTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGF 549
           T  AC G+ N +  LEH QA +T++  RRGDL I++ SPMGT+S LL+ RP  D S  GF
Sbjct: 470 TVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPH-DYSADGF 528

Query: 550 DKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
           + W FMTTH+W ED  G W LE+     A   G L ++TL+L+GT
Sbjct: 529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGT 573


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score =  504 bits (1298), Expect = e-143
 Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
           WGE A G WTLE+      V +  ++G LKEW+L+L+GT   PY        +S++    
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653

Query: 616 KEELE 620
             ELE
Sbjct: 654 APELE 658


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score =  504 bits (1298), Expect = e-143
 Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
           WGE A G WTLE+      V +  ++G LKEW+L+L+GT   PY        +S++    
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653

Query: 616 KEELE 620
             ELE
Sbjct: 654 APELE 658


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score =  504 bits (1298), Expect = e-143
 Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
           WGE A G WTLE+      V +  ++G LKEW+L+L+GT   PY        +S++    
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653

Query: 616 KEELE 620
             ELE
Sbjct: 654 APELE 658


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score =  504 bits (1298), Expect = e-143
 Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615
           WGE A G WTLE+      V +  ++G LKEW+L+L+GT   PY        +S++    
Sbjct: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653

Query: 616 KEELE 620
             ELE
Sbjct: 654 APELE 658


>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
           sapiens]
          Length = 755

 Score =  485 bits (1249), Expect = e-137
 Identities = 262/576 (45%), Positives = 364/576 (63%), Gaps = 26/576 (4%)

Query: 22  FASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLY-HFYHNGLAKAKRR 80
           +A    P++ + + V++ +G  +  R +A + GF      F +G Y H  H G+ +    
Sbjct: 26  WAPVRAPIYVSSWAVQVSQGNREVER-LARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLT 84

Query: 81  RSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADG 140
               H+  L+++P+V+   QQ    R KR         +   DP F+KQWY+ +  Q D 
Sbjct: 85  PHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV-------VVPTDPWFSKQWYMNSEAQPD- 136

Query: 141 TPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRY 200
                L++ +AW  G +G+G+ + ++DDGI+  HPDL +NY+  ASYDF+  DP P PRY
Sbjct: 137 -----LSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRY 191

Query: 201 TDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQ 260
           T    N HGTRCAGEV+A ANN  CGVGVA+N+++ G+RMLD   +TD+IEA S+S  PQ
Sbjct: 192 TPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGT-ITDVIEAQSLSLQPQ 250

Query: 261 LIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNC 319
            I IYSASWGP D+G+TVDGP  LT +A   GV KGRGG G++++WASG+GG  YD+CNC
Sbjct: 251 HIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNC 310

Query: 320 DGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLR 379
           DGY +S+ T+S+ S    GR   Y E+C+STL +T+S+G   +P+  + TTDL+  CT +
Sbjct: 311 DGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQ--IVTTDLHHGCTDQ 368

Query: 380 HSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFN 439
           H+GTSA+AP AAG+ ALALEAN  LTWRDMQHL V  SK    H +   WR NGVG + +
Sbjct: 369 HTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASK--PAHLQAEDWRTNGVGRQVS 426

Query: 440 HLFGYGVLDAGAMVKMAKDW-KTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKE 498
           H +GYG+LDAG +V  A+ W  T P+R   V   VQ     P    + +     AC G  
Sbjct: 427 HHYGYGLLDAGLLVDTARTWLPTQPQRKCAV--RVQS-RPTPILPLIYIRENVSACAGLH 483

Query: 499 NFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTH 558
           N +R LEHVQA +T++ +RRGDL I++TSPMGT+S L++ RP D  ++ G++ W FM+TH
Sbjct: 484 NSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTE-GYNNWVFMSTH 542

Query: 559 TWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
            W E+ +G WTL L   G     G L  +TL+L+GT
Sbjct: 543 FWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGT 578


>gi|20336188 paired basic amino acid cleaving system 4 isoform e
           preproprotein [Homo sapiens]
          Length = 623

 Score =  484 bits (1245), Expect = e-136
 Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL 572
           WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606


>gi|27894285 paired basic amino acid cleaving system 4 isoform f
           preproprotein [Homo sapiens]
          Length = 664

 Score =  484 bits (1245), Expect = e-136
 Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL 572
           WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606


>gi|20336190 paired basic amino acid cleaving system 4 isoform d
           preproprotein [Homo sapiens]
          Length = 652

 Score =  484 bits (1245), Expect = e-136
 Identities = 268/553 (48%), Positives = 346/553 (62%), Gaps = 12/553 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474

Query: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534

Query: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593

Query: 560 WGEDARGTWTLEL 572
           WGE A G WTLE+
Sbjct: 594 WGEKAEGQWTLEI 606


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score =  477 bits (1228), Expect = e-134
 Identities = 262/578 (45%), Positives = 352/578 (60%), Gaps = 15/578 (2%)

Query: 29  VFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQ 87
           V+TNH+ V++  GG  +A ++A+++GF  + ++   +  YHFYH+   K     S     
Sbjct: 34  VYTNHWAVKI-AGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHS 92

Query: 88  QLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLN 147
            +  +P+V+   QQ    R KR Y          NDP +   WY+  +         D+N
Sbjct: 93  FISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQS-DMN 151

Query: 148 VAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNS 207
           +  AW+ GYTGK + + I+DDGI+  HPDL  NY+A AS D + ND  P PRY     N 
Sbjct: 152 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK 211

Query: 208 HGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSA 267
           HGTRCAGEV+AAANN+ C VG+A+N+K+ G+RMLD   +TD++EA S+S  PQ + IYSA
Sbjct: 212 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGD-VTDMVEAKSVSFNPQHVHIYSA 270

Query: 268 SWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSM 326
           SWGP D+GKTVDGP  LT QA  +GV  GR G GS++VWASG+GG S D C+CDGY +S+
Sbjct: 271 SWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSI 330

Query: 327 WTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAA 386
           +TISI+S    G+   Y E CSSTLA+T+S+G   + +  + TTDL   CT  H+GTSA+
Sbjct: 331 YTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKK--IITTDLRQRCTDNHTGTSAS 388

Query: 387 APEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGV 446
           AP AAG+ ALALEAN  LTWRD+QH+ V TS+   L+   + W+ N  G + +HL+G+G+
Sbjct: 389 APMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLN--ANDWKTNAAGFKVSHLYGFGL 446

Query: 447 LDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKEN-FVRYLE 505
           +DA AMV  A+ W TVP +  CV  + +  + I     +        C    N  V YLE
Sbjct: 447 MDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLE 506

Query: 506 HVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDAR 565
           HV   IT+   RRGDL I +TSP GT+S LL+ R   D S  GF  W FMT H WGE A 
Sbjct: 507 HVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR-LFDHSMEGFKNWEFMTIHCWGERAA 565

Query: 566 GTWTLELGFVGSAPQK----GVLKEWTLMLHGTQSAPY 599
           G W LE+    S  +     G LKEW+L+L+GT   PY
Sbjct: 566 GDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY 603


>gi|20336248 proprotein convertase subtilisin/kexin type 7
           preproprotein [Homo sapiens]
          Length = 785

 Score =  377 bits (967), Expect = e-104
 Identities = 206/481 (42%), Positives = 290/481 (60%), Gaps = 13/481 (2%)

Query: 119 INMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLA 178
           ++ NDP + +QW+L N      +PG D+NV   WE   TG+GVT+ ++DDG+++   D+A
Sbjct: 143 VHFNDPKYPQQWHLNNRR----SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIA 198

Query: 179 SNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGI 238
            NY+ E SYD +SNDP P P    +  N HGTRCAGE++A  NN+ C VGVAY S++AGI
Sbjct: 199 PNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGI 258

Query: 239 RMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRG 298
           R+LD P +TD +EA + +   Q+ DIYS SWGP D+GKTVDGP +L   A+  GV  GR 
Sbjct: 259 RVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQ 317

Query: 299 GKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSN 357
           G GSI+V ASG+GG + D+CN DGYA+S++T++I +   +GR   Y E C+S LA TFS 
Sbjct: 318 GFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSG 377

Query: 358 GRKRNPEAGVATTDLY--GNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVL 415
           G K          DL     CT  H+GTSAAAP AAG+ AL L+    LTWRD+QH+ V 
Sbjct: 378 GDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVF 437

Query: 416 TSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
           T+ R +  D   +W  N  G   +H  G+G+L+A  +V  AK W +VP     V   +++
Sbjct: 438 TATRYE--DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKE 495

Query: 476 PEKIP-STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI 534
            + IP S   L +       + + + ++ LEHV   +++   RRG L + +  P G  S+
Sbjct: 496 NKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSL 555

Query: 535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHG 593
           + + R  D D   GF+ W F T   WGE ARGT+ L +  VG    Q G+L++W L L+G
Sbjct: 556 IGAPRSMDSDPN-GFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614

Query: 594 T 594
           +
Sbjct: 615 S 615


>gi|20336186 paired basic amino acid cleaving system 4 isoform c
           preproprotein [Homo sapiens]
          Length = 487

 Score =  372 bits (956), Expect = e-103
 Identities = 205/415 (49%), Positives = 266/415 (64%), Gaps = 10/415 (2%)

Query: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121

Query: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179

Query: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239

Query: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298

Query: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358

Query: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416

Query: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVG 435
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G
Sbjct: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAG 469


>gi|4506775 membrane-bound transcription factor site-1 protease
           preproprotein [Homo sapiens]
          Length = 1052

 Score = 36.2 bits (82), Expect = 0.095
 Identities = 63/256 (24%), Positives = 101/256 (39%), Gaps = 43/256 (16%)

Query: 152 WELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTR 211
           W++GYTG  V + + D G+   HP      N +   ++++       R  DD    HGT 
Sbjct: 203 WQMGYTGANVRVAVFDTGLSEKHPHFK---NVKERTNWTNE------RTLDDGL-GHGTF 252

Query: 212 CAGEVSAAANNNICGVGVAYNSKVAGIRMLDQ---PFMTDIIEASSISHMPQLIDIYSAS 268
            AG +++         G A ++++   R+       + +  ++A + + + + ID+ + S
Sbjct: 253 VAGVIASMRECQ----GFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK-IDVLNLS 307

Query: 269 WGPTD--NGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASG-DGGSYDDCNCDGYASS 325
            G  D  +   VD   ELT                 I V A G DG  Y   N    A  
Sbjct: 308 IGGPDFMDHPFVDKVWELT-------------ANNVIMVSAIGNDGPLYGTLN--NPADQ 352

Query: 326 MWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPE-----AGVATTDLYGNCTLRH 380
           M  I +     +   A +     +T       GR + P+     AGV  + + G C    
Sbjct: 353 MDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMK-PDIVTYGAGVRGSGVKGGCRAL- 410

Query: 381 SGTSAAAPEAAGVFAL 396
           SGTS A+P  AG   L
Sbjct: 411 SGTSVASPVVAGAVTL 426


>gi|5803167 splicing factor 3a, subunit 3 [Homo sapiens]
          Length = 501

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 5/76 (6%)

Query: 153 ELGYTGKGVTIGIMDDGIDY----LHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSH 208
           E+ Y  K + +G     I Y    LH  L  NYN E   +++   P  + R+  +W ++H
Sbjct: 375 EIIYNPKNLPLGWDGKPIPYWLYKLH-GLNINYNCEICGNYTYRGPKAFQRHFAEWRHAH 433

Query: 209 GTRCAGEVSAAANNNI 224
           G RC G  + A   N+
Sbjct: 434 GMRCLGIPNTAHFANV 449


>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
          Length = 789

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/123 (24%), Positives = 49/123 (39%), Gaps = 8/123 (6%)

Query: 83  LHHKQQLERDPRVKMALQQEGFDRKK-RGYRDINEI-----DINMNDPLFTKQWYLINTG 136
           +H  ++L+R+ +    L+ +  DRK  R     +E      DIN N+P FTK  Y  +  
Sbjct: 110 IHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVP 169

Query: 137 QAD--GTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDP 194
           +    GT  + +   +A +  Y      +  +  G  Y   D  S     A  D S  + 
Sbjct: 170 EMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENR 229

Query: 195 YPY 197
             Y
Sbjct: 230 EQY 232


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 18/95 (18%), Positives = 41/95 (43%)

Query: 368  ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
            ATT ++ N   + S + + +     +  +  + N+  TW+ + H T   +K +++++   
Sbjct: 1889 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 1948

Query: 428  QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
                 GVG + N     G  +  +    A+ W  +
Sbjct: 1949 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 1983


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 18/95 (18%), Positives = 41/95 (43%)

Query: 368 ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
           ATT ++ N   + S + + +     +  +  + N+  TW+ + H T   +K +++++   
Sbjct: 130 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 189

Query: 428 QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
                GVG + N     G  +  +    A+ W  +
Sbjct: 190 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 224


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 18/95 (18%), Positives = 41/95 (43%)

Query: 368  ATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVH 427
            ATT ++ N   + S + + +     +  +  + N+  TW+ + H T   +K +++++   
Sbjct: 1885 ATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTE 1944

Query: 428  QWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTV 462
                 GVG + N     G  +  +    A+ W  +
Sbjct: 1945 SLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRI 1979


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score = 32.0 bits (71), Expect = 1.8
 Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 7/71 (9%)

Query: 88  QLERDPRVKMALQQEGFD-----RKKRGYRDINEIDINMNDPLFTKQWY--LINTGQADG 140
           +L+R+ R    LQ E +D     R+ +   D+  +DIN + P F +  Y  +++   A G
Sbjct: 212 ELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPG 271

Query: 141 TPGLDLNVAEA 151
           +P L +  ++A
Sbjct: 272 SPVLQVFASDA 282


>gi|239754979 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 780

 Score = 31.6 bits (70), Expect = 2.3
 Identities = 19/66 (28%), Positives = 27/66 (40%), Gaps = 1/66 (1%)

Query: 342 LYDESCSSTLASTFSN-GRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEA 400
           LY  S S+TL            P   +    L  +CT   +  + AAP A  V  ++ E 
Sbjct: 397 LYFSSSSATLVEAAERTASPPGPSVSLTVCSLCSSCTFSVAAAAPAAPSACDVLKMSEER 456

Query: 401 NLGLTW 406
           +L L W
Sbjct: 457 SLELRW 462


>gi|62739166 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
           isoform b precursor [Homo sapiens]
          Length = 737

 Score = 30.0 bits (66), Expect = 6.8
 Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 3/60 (5%)

Query: 468 CVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFV---RYLEHVQAVITVNATRRGDLNIN 524
           C+G   + P  IP+   LV+T+ T   +G   F+   +Y  +   V+      RG   IN
Sbjct: 23  CLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGIN 82


>gi|33636742 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
           isoform a precursor [Homo sapiens]
          Length = 758

 Score = 30.0 bits (66), Expect = 6.8
 Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 3/60 (5%)

Query: 468 CVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFV---RYLEHVQAVITVNATRRGDLNIN 524
           C+G   + P  IP+   LV+T+ T   +G   F+   +Y  +   V+      RG   IN
Sbjct: 23  CLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGIN 82


>gi|31317307 proprotein convertase subtilisin/kexin type 9
           preproprotein [Homo sapiens]
          Length = 692

 Score = 30.0 bits (66), Expect = 6.8
 Identities = 15/49 (30%), Positives = 27/49 (55%)

Query: 376 CTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHD 424
           C +  SGTS AA   AG+ A+ L A   LT  +++   +  S ++ +++
Sbjct: 378 CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINE 426


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,123,038
Number of Sequences: 37866
Number of extensions: 1139257
Number of successful extensions: 2818
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2681
Number of HSP's gapped (non-prelim): 30
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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