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Search of human proteins with 11342678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11342678 amyloid beta (A4) precursor protein-binding, family
A, member 3 [Homo sapiens]
(575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11342678 amyloid beta (A4) precursor protein-binding, family ... 1165 0.0
gi|22035548 amyloid beta A4 precursor protein-binding, family A,... 514 e-146
gi|194353992 amyloid beta A4 precursor protein-binding, family A... 488 e-138
gi|22035550 amyloid beta A4 precursor protein-binding, family A,... 479 e-135
gi|134152672 syndecan binding protein 2 isoform a [Homo sapiens] 66 1e-10
gi|38016916 syndecan binding protein 2 isoform b [Homo sapiens] 66 1e-10
gi|55749523 syntenin isoform 3 [Homo sapiens] 57 5e-08
gi|55749515 syntenin isoform 3 [Homo sapiens] 57 5e-08
gi|55749504 syntenin isoform 2 [Homo sapiens] 57 5e-08
gi|55749490 syntenin isoform 1 [Homo sapiens] 57 5e-08
gi|56243522 syntenin isoform 1 [Homo sapiens] 57 5e-08
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 52 2e-06
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 52 2e-06
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 52 2e-06
gi|148746189 multiple PDZ domain protein [Homo sapiens] 51 3e-06
gi|112382257 InaD-like [Homo sapiens] 51 3e-06
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 50 4e-06
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 50 4e-06
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 50 4e-06
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 50 7e-06
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 50 7e-06
gi|224586793 src homology 2 domain-containing transforming prote... 49 1e-05
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 49 1e-05
gi|148612825 Rap GTPase interactor [Homo sapiens] 49 1e-05
gi|45827729 scribble isoform b [Homo sapiens] 49 1e-05
gi|45827731 scribble isoform a [Homo sapiens] 49 1e-05
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 49 1e-05
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 49 1e-05
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 49 2e-05
gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo ... 48 3e-05
>gi|11342678 amyloid beta (A4) precursor protein-binding, family A,
member 3 [Homo sapiens]
Length = 575
Score = 1165 bits (3014), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQEL 60
MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQEL
Sbjct: 1 MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQEL 60
Query: 61 VQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEE 120
VQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEE
Sbjct: 61 VQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEE 120
Query: 121 CPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP 180
CPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP
Sbjct: 121 CPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP 180
Query: 181 LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS 240
LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS
Sbjct: 181 LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS 240
Query: 241 TRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADI 300
TRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADI
Sbjct: 241 TRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADI 300
Query: 301 GCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRES 360
GCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRES
Sbjct: 301 GCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRES 360
Query: 361 GIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPT 420
GIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPT
Sbjct: 361 GIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPT 420
Query: 421 AVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHC 480
AVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHC
Sbjct: 421 AVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHC 480
Query: 481 PPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHA 540
PPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHA
Sbjct: 481 PPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHA 540
Query: 541 RIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
RIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL
Sbjct: 541 RIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
>gi|22035548 amyloid beta A4 precursor protein-binding, family A,
member 1 [Homo sapiens]
Length = 837
Score = 514 bits (1324), Expect = e-146
Identities = 270/477 (56%), Positives = 343/477 (71%), Gaps = 39/477 (8%)
Query: 128 PEEPLEPAPRLLQ---PPEDPDE----DSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP 180
P+EP EP + Q P D D+ D DSP S+ G+ SSS+S P
Sbjct: 371 PDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPS---PGSSSPLGAESSSTSLHP------ 421
Query: 181 LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS 240
P E +S ++LAS+P EVPGPCD EDL+DG+IF A YLGSTQL+S++ P +
Sbjct: 422 -SDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN 480
Query: 241 TRMAQAREAMDRVK-----------APDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDH 289
RM QA+EA+ R+K AP+GE+QPMTEVDLF+ST+RIKVL AD+QE MMDH
Sbjct: 481 VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH 540
Query: 290 ALHTISYTADIGCVLVLMARRRLARRPA--------PQDHGRRLYKMLCHVFYAEDAQLI 341
L TISY ADIG ++VLMARRR+ R + P G+R YKM+CHVF +EDAQLI
Sbjct: 541 PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI 600
Query: 342 AQAIGQAFAAAYSQFLRESGIDP---SQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLE 398
AQ+IGQAF+ AY +FLR +GI+P SQ ++N DL HFS S+NC++V +E
Sbjct: 601 AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE 660
Query: 399 KRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLA 458
K++GE LGV +VESGWGS+LPT +IAN++HGGPAE+SG L+IGD++ +INGTSLVGLPL+
Sbjct: 661 KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
Query: 459 ACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERG 518
CQ+ ++ K+Q+ V L+IV CPPVTT +I RP R QLGF V++GIICSL+RGGIAERG
Sbjct: 721 TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG 780
Query: 519 GIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
G+RVGHRIIEINGQSVVATPH +I+ +L+ A GE+H+KTMPAA YRLLT QEQPVY+
Sbjct: 781 GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
>gi|194353992 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform b [Homo sapiens]
Length = 737
Score = 488 bits (1256), Expect = e-138
Identities = 246/396 (62%), Positives = 310/396 (78%), Gaps = 15/396 (3%)
Query: 194 PET--LASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMD 251
PET +AS+P+ VPGPC+ EDL+DG+IF A YLGSTQL+SERNP + RM QA+EA+
Sbjct: 343 PETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVS 402
Query: 252 RVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADIGCVLVLMARRR 311
RVK +G+ Q +TEVDLF+ST+RIKVL AD+QE MMDHAL TISY ADIG ++VLMARRR
Sbjct: 403 RVKNSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRR 462
Query: 312 LARRPAPQD---------HGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRESGI 362
+ R A QD G++ YKM+CHVF +EDAQLIAQ+IGQAF+ AY +FLR +GI
Sbjct: 463 MPRS-ASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGI 521
Query: 363 DP---SQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLP 419
+P SQ ++N DL HFSNS+NC+E+ LEK +GE LGV +VESGWGS+LP
Sbjct: 522 NPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILP 581
Query: 420 TAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVH 479
T ++AN+++GGPA RSG LSIGD++ +INGTSLVGLPLA CQ ++ K+QT V L+IV
Sbjct: 582 TVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVS 641
Query: 480 CPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPH 539
CPPVTT +I RP + QLGF V++GIICSL+RGGIAERGG+RVGHRIIEINGQSVVAT H
Sbjct: 642 CPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAH 701
Query: 540 ARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
+I++ L+ + GE+H+KTMPAA +RLLTGQE P+Y+
Sbjct: 702 EKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 737
>gi|22035550 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform a [Homo sapiens]
Length = 749
Score = 479 bits (1234), Expect = e-135
Identities = 246/408 (60%), Positives = 310/408 (75%), Gaps = 27/408 (6%)
Query: 194 PET--LASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMD 251
PET +AS+P+ VPGPC+ EDL+DG+IF A YLGSTQL+SERNP + RM QA+EA+
Sbjct: 343 PETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVS 402
Query: 252 RVKA------------PDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTAD 299
RVK +G+ Q +TEVDLF+ST+RIKVL AD+QE MMDHAL TISY AD
Sbjct: 403 RVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIAD 462
Query: 300 IGCVLVLMARRRLARRPAPQD---------HGRRLYKMLCHVFYAEDAQLIAQAIGQAFA 350
IG ++VLMARRR+ R A QD G++ YKM+CHVF +EDAQLIAQ+IGQAF+
Sbjct: 463 IGNIVVLMARRRMPRS-ASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFS 521
Query: 351 AAYSQFLRESGIDP---SQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGV 407
AY +FLR +GI+P SQ ++N DL HFSNS+NC+E+ LEK +GE LGV
Sbjct: 522 VAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGV 581
Query: 408 ALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRET 467
+VESGWGS+LPT ++AN+++GGPA RSG LSIGD++ +INGTSLVGLPLA CQ ++
Sbjct: 582 VVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGL 641
Query: 468 KSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRII 527
K+QT V L+IV CPPVTT +I RP + QLGF V++GIICSL+RGGIAERGG+RVGHRII
Sbjct: 642 KNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRII 701
Query: 528 EINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
EINGQSVVAT H +I++ L+ + GE+H+KTMPAA +RLLTGQE P+Y+
Sbjct: 702 EINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 749
>gi|134152672 syndecan binding protein 2 isoform a [Homo sapiens]
Length = 292
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 393 REVHL--EKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGT 450
RE+HL ++R GL + V+ G L V AN PA G L GD+L I+G
Sbjct: 107 REIHLCKDERGKTGLRLRKVDQG---LFVQLVQANT----PASLVG-LRFGDQLLQIDGR 158
Query: 451 SLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLL 510
G V++ V +V P + + +GF ++ G I SL+
Sbjct: 159 DCAGWSSHKAHQVVKKASGDKIVV--VVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLV 216
Query: 511 RGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQE 570
+G A R G+ H + E++GQ+V+ +I+E+L A V + +P+ Y + +
Sbjct: 217 KGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKL 276
Query: 571 QPVYL 575
PV L
Sbjct: 277 PPVLL 281
>gi|38016916 syndecan binding protein 2 isoform b [Homo sapiens]
Length = 207
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 393 REVHL--EKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGT 450
RE+HL ++R GL + V+ G L V AN PA G L GD+L I+G
Sbjct: 22 REIHLCKDERGKTGLRLRKVDQG---LFVQLVQANT----PASLVG-LRFGDQLLQIDGR 73
Query: 451 SLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLL 510
G V++ V +V P + + +GF ++ G I SL+
Sbjct: 74 DCAGWSSHKAHQVVKKASGDKIVV--VVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLV 131
Query: 511 RGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQE 570
+G A R G+ H + E++GQ+V+ +I+E+L A V + +P+ Y + +
Sbjct: 132 KGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKL 191
Query: 571 QPVYL 575
PV L
Sbjct: 192 PPVLL 196
>gi|55749523 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
REV L K + +G+ L + + L+ L GD++ ING +
Sbjct: 112 REVILCKDQDGKIGLRLKS------IDNGIFVQLVQANSPASLVGLRFGDQVLQINGENC 165
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRG 512
G +++ + +T++I P T +H+ + +GF ++G I S+++
Sbjct: 166 AGWSSDKAHKVLKQAFGE-KITMTIRDRPFERTITMHKD-STGHVGFIFKNGKITSIVKD 223
Query: 513 GIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQP 572
A R G+ H I EINGQ+V+ ++I ++L+ + V I MPA + + + P
Sbjct: 224 SSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAP 283
>gi|55749515 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
REV L K + +G+ L + + L+ L GD++ ING +
Sbjct: 112 REVILCKDQDGKIGLRLKS------IDNGIFVQLVQANSPASLVGLRFGDQVLQINGENC 165
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRG 512
G +++ + +T++I P T +H+ + +GF ++G I S+++
Sbjct: 166 AGWSSDKAHKVLKQAFGE-KITMTIRDRPFERTITMHKD-STGHVGFIFKNGKITSIVKD 223
Query: 513 GIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQP 572
A R G+ H I EINGQ+V+ ++I ++L+ + V I MPA + + + P
Sbjct: 224 SSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAP 283
>gi|55749504 syntenin isoform 2 [Homo sapiens]
Length = 292
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
REV L K + +G+ L + + L+ L GD++ ING +
Sbjct: 107 REVILCKDQDGKIGLRLKS------IDNGIFVQLVQANSPASLVGLRFGDQVLQINGENC 160
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRG 512
G +++ + +T++I P T +H+ + +GF ++G I S+++
Sbjct: 161 AGWSSDKAHKVLKQAFGE-KITMTIRDRPFERTITMHKD-STGHVGFIFKNGKITSIVKD 218
Query: 513 GIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQP 572
A R G+ H I EINGQ+V+ ++I ++L+ + V I MPA + + + P
Sbjct: 219 SSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAP 278
>gi|55749490 syntenin isoform 1 [Homo sapiens]
Length = 298
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
REV L K + +G+ L + + L+ L GD++ ING +
Sbjct: 113 REVILCKDQDGKIGLRLKS------IDNGIFVQLVQANSPASLVGLRFGDQVLQINGENC 166
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRG 512
G +++ + +T++I P T +H+ + +GF ++G I S+++
Sbjct: 167 AGWSSDKAHKVLKQAFGE-KITMTIRDRPFERTITMHKD-STGHVGFIFKNGKITSIVKD 224
Query: 513 GIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQP 572
A R G+ H I EINGQ+V+ ++I ++L+ + V I MPA + + + P
Sbjct: 225 SSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAP 284
>gi|56243522 syntenin isoform 1 [Homo sapiens]
Length = 298
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/180 (24%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
REV L K + +G+ L + + L+ L GD++ ING +
Sbjct: 113 REVILCKDQDGKIGLRLKS------IDNGIFVQLVQANSPASLVGLRFGDQVLQINGENC 166
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRG 512
G +++ + +T++I P T +H+ + +GF ++G I S+++
Sbjct: 167 AGWSSDKAHKVLKQAFGE-KITMTIRDRPFERTITMHKD-STGHVGFIFKNGKITSIVKD 224
Query: 513 GIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQP 572
A R G+ H I EINGQ+V+ ++I ++L+ + V I MPA + + + P
Sbjct: 225 SSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAP 284
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 380 NGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALS 439
NGD+D N R V +K E +G+ L + L ++A ++HGG R G L
Sbjct: 471 NGDMD-MENVTRVRLVQFQKNTDEPMGITLKMNE----LNHCIVARIMHGGMIHRQGTLH 525
Query: 440 IGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
+GD + ING S+ + Q +RE + S+T IV
Sbjct: 526 VGDEIREINGISVANQTVEQLQKMLREMRG--SITFKIV 562
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 380 NGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALS 439
NGD+D N R V +K E +G+ L + L ++A ++HGG R G L
Sbjct: 477 NGDMD-MENVTRVRLVQFQKNTDEPMGITLKMNE----LNHCIVARIMHGGMIHRQGTLH 531
Query: 440 IGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
+GD + ING S+ + Q +RE + S+T IV
Sbjct: 532 VGDEIREINGISVANQTVEQLQKMLREMRG--SITFKIV 568
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 380 NGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALS 439
NGD+D N R V +K E +G+ L + L ++A ++HGG R G L
Sbjct: 477 NGDMD-MENVTRVRLVQFQKNTDEPMGITLKMNE----LNHCIVARIMHGGMIHRQGTLH 531
Query: 440 IGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
+GD + ING S+ + Q +RE + S+T IV
Sbjct: 532 VGDEIREINGISVANQTVEQLQKMLREMRG--SITFKIV 568
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 50.8 bits (120), Expect = 3e-06
Identities = 48/208 (23%), Positives = 87/208 (41%), Gaps = 35/208 (16%)
Query: 395 VHLEKRRGEGLGVALVESGWGSLLPTAV-IANLLHGGPAERSGALSIGDRLTAINGTSLV 453
+ L+K+ G+GLG+++V G T V +++++ GG A+ G L GD++ +NG +
Sbjct: 1726 IELQKKPGKGLGLSIV----GKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
Query: 454 GLPLAACQAAVRETK------------SQTSVTLSIVHCPPVTTAIIH-------RPHAR 494
A A ++ ++ S TS +L + I +
Sbjct: 1782 NATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPT 1841
Query: 495 EQLGFCVEDGIICSL-----------LRGGIAERGGIRVGHRIIEINGQSVVATPHARII 543
+ LG + G+ L G A+ +RVG RI+ I G S H + +
Sbjct: 1842 DSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
Query: 544 ELLTEAYGEVHIKTMPAATYRLLTGQEQ 571
LL A G + ++ + ++TG +Q
Sbjct: 1902 NLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
Score = 44.3 bits (103), Expect = 3e-04
Identities = 46/182 (25%), Positives = 81/182 (44%), Gaps = 19/182 (10%)
Query: 394 EVHLEKRRGE-GLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
E +E +G GLG+++V G +LL +I + G A + G L GD++ +NG L
Sbjct: 1627 ETTIEISKGRTGLGLSIV-GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
Query: 453 VGLPLAACQAAVRETKSQTSVTL--------SIVHCPPVTTAIIHRPHAREQLGFCV--- 501
+R+T + +TL C +T + +P + LG +
Sbjct: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKP--GKGLGLSIVGK 1743
Query: 502 --EDGIICS-LLRGGIAERGG-IRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKT 557
+ G+ S +++GGIA+ G + G +I+ +NG+ V + LL + G + T
Sbjct: 1744 RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFT 1803
Query: 558 MP 559
P
Sbjct: 1804 FP 1805
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 387 SNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTA 446
S+ N + + L K +G GLG+A+ E L +I +L G A G L +GD++ A
Sbjct: 1476 SSFKNVQHLELPKDQG-GLGIAISEE---DTLSGVIIKSLTEHGVAATDGRLKVGDQILA 1531
Query: 447 INGTSLVGLPLAACQAAVRETKSQTSVTL 475
++ +VG P+ + ++ K +T+
Sbjct: 1532 VDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 39.7 bits (91), Expect = 0.008
Identities = 32/90 (35%), Positives = 48/90 (53%), Gaps = 8/90 (8%)
Query: 392 CREVHLEKRRGEGLGVALVESGWGSL---LPTAVIANLLHGGPAERSGALSIGDRLTAIN 448
C+ + LE R +GLG ++V G+GS LP V + G A G L GD++ A+N
Sbjct: 1956 CKSITLE-RGPDGLGFSIV-GGYGSPHGDLPIYV-KTVFAKGAASEDGRLKRGDQIIAVN 2012
Query: 449 GTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
G SL G+ A ++ TK +VTL ++
Sbjct: 2013 GQSLEGVTHEEAVAILKRTKG--TVTLMVL 2040
Score = 38.9 bits (89), Expect = 0.013
Identities = 44/217 (20%), Positives = 79/217 (36%), Gaps = 47/217 (21%)
Query: 387 SNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHG-GPAERSGALSIGDRLT 445
S R V ++K + LG+++ L + ++H G A ++ L +GDR+
Sbjct: 1826 SEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIV 1885
Query: 446 AINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHR--------------- 490
I GTS G + QA + S+ + +V V+ H+
Sbjct: 1886 TICGTSTEG--MTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTS 1943
Query: 491 ----------PHAR--------EQLGFCVEDG-----------IICSLLRGGIAERGGIR 521
P + + LGF + G + +G +E G ++
Sbjct: 1944 SSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLK 2003
Query: 522 VGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTM 558
G +II +NGQS+ H + +L G V + +
Sbjct: 2004 RGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 38.1 bits (87), Expect = 0.022
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 350 AAAYSQFLRESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGE-GLGVA 408
+A L +S S+ + S AC+ L + S R +++ K G+ V+
Sbjct: 964 SAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVS 1023
Query: 409 LVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVR 465
+ G G ++ +++HGG R G ++IGD + +IN S + + A +A +R
Sbjct: 1024 ANKDGLGM-----IVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 18/118 (15%)
Query: 396 HLEKRRG-EGLGVALVE--SGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSL 452
H+E +G +GLG ++++ +I +L+ GG AE+ G L GDRL +N
Sbjct: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVND--- 756
Query: 453 VGLPLAACQAAVRETKSQTSVTLSIVHCPPV------------TTAIIHRPHAREQLG 498
V L ++ + AV K S T+ I P+ + ++ PH+ E+ G
Sbjct: 757 VNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAG 814
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 7/74 (9%)
Query: 386 FSNSDNCREVHLEKRRGEGLGVALVES-GWGSLLPTA------VIANLLHGGPAERSGAL 438
+SN + R V L + + LG+++V G GS L I ++L PA ++G L
Sbjct: 1143 YSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTL 1202
Query: 439 SIGDRLTAINGTSL 452
GDR+ ++G L
Sbjct: 1203 KPGDRIVEVDGMDL 1216
Score = 33.1 bits (74), Expect = 0.71
Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 2/75 (2%)
Query: 403 EGLGVALVES-GWGSLLPTAV-IANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAAC 460
+GLG+ + G L P+ + + ++ E G + IGD++ A++GT+L G
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 461 QAAVRETKSQTSVTL 475
+R T +TL
Sbjct: 445 VEVLRHTGQTVLLTL 459
Score = 30.4 bits (67), Expect = 4.6
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query: 412 SGWGSLLPTAV----IANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
SG G L V I ++L GP SG L GD L +NG +L+G
Sbjct: 563 SGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 50.8 bits (120), Expect = 3e-06
Identities = 56/255 (21%), Positives = 95/255 (37%), Gaps = 70/255 (27%)
Query: 382 DLDHFSNSDNCR--EVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALS 439
D H+ + +N V L+K+ G GLG+++V GS I++++ GG A+ G L
Sbjct: 1519 DEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGS---GVFISDIVKGGAADLDGRLI 1575
Query: 440 IGDRLTAINGTSL----------------------VGLPLAACQAAVRETKSQTSVTLSI 477
GD++ ++NG + +G A + R T + +
Sbjct: 1576 QGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQS 1635
Query: 478 VH--CPP------------VTTAIIHRPHAR------------------EQLGFCVEDG- 504
H C P V T + P + + LG + G
Sbjct: 1636 AHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGR 1695
Query: 505 ---------IICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVH 554
I + G+A R ++VG RI+ INGQ + HA ++ LL AYG +
Sbjct: 1696 GSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRII 1755
Query: 555 IKTMPAATYRLLTGQ 569
++ + + Q
Sbjct: 1756 LQVVADTNISAIAAQ 1770
Score = 36.6 bits (83), Expect = 0.064
Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 15/178 (8%)
Query: 393 REVHLEKRRGE-GLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTS 451
+E+ +E +G GLG+++V G + L VI + G A R G L GD++ +NG
Sbjct: 1434 QEMIIEISKGRSGLGLSIV-GGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492
Query: 452 LVGLPLAACQAAVRET--KSQTSVTLSIVHCPPVTTAIIH----RPHAREQLGFCV---- 501
L A+R+T K + V H I + A LG +
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKR 1552
Query: 502 --EDGIICSLLRGGIAERGGIRV-GHRIIEINGQSVVATPHARIIELLTEAYGEVHIK 556
I +++GG A+ G + G +I+ +NG+ + + +L A G V ++
Sbjct: 1553 NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLE 1610
Score = 36.2 bits (82), Expect = 0.084
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 4/54 (7%)
Query: 402 GEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGL 455
G GLG +V G V+ ++ GG A+R G L GD + I GT++ G+
Sbjct: 255 GSGLGFGIV----GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
Score = 32.7 bits (73), Expect = 0.93
Identities = 44/175 (25%), Positives = 70/175 (40%), Gaps = 51/175 (29%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVG----------------LPLAAC------ 460
I++++ GGP + G L D L +NG L G L C
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDD 642
Query: 461 QAAVRETK-SQTSVTLSIV-HCPPVTTA---------------IIHRPHAREQLGFCVED 503
+A+V E + ++TS+ + V H V T I+ + LGF + D
Sbjct: 643 EASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD 702
Query: 504 G-----------IICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELL 546
+I SL+ G+AER GG+ G R++ +N + T A +E+L
Sbjct: 703 YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL 757
Score = 32.3 bits (72), Expect = 1.2
Identities = 43/204 (21%), Positives = 81/204 (39%), Gaps = 29/204 (14%)
Query: 380 NGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAV-IANLLHGGPAERSGAL 438
N + + + +E+ GLG ++V +L + + ++ G A+R L
Sbjct: 120 NSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRL 179
Query: 439 SIGDRLTAINGTSL-----------------VGLPLAACQAAVRETKSQTSVTLSIVHCP 481
D++ AIN T L L L + V TKS TS +L+ P
Sbjct: 180 KENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPV-HTKSSTSSSLNDTTLP 238
Query: 482 PVT----TAIIHRPHAREQLGFCVEDG-----IICSLLRGGIAERGG-IRVGHRIIEING 531
+ + LGF + G ++ +++ GG+A+R G ++ G I++I G
Sbjct: 239 ETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
Query: 532 QSVVATPHARIIELLTEAYGEVHI 555
+V ++ ++L V +
Sbjct: 299 TNVQGMTSEQVAQVLRNCGNSVRM 322
Score = 32.0 bits (71), Expect = 1.6
Identities = 24/59 (40%), Positives = 33/59 (55%), Gaps = 4/59 (6%)
Query: 403 EGLGVALVESGWGSLLPTA---VIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLA 458
+GLG ++++ L PT VI +L+ G AERSG L GDRL ++N L LA
Sbjct: 694 KGLGFSILDYQ-DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLA 751
Score = 30.0 bits (66), Expect = 6.0
Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 10/115 (8%)
Query: 385 HFSNSDNCREVHLEKRRGEGLGVALVESGW-------GSLLPTAVIANLLHGGPAERSGA 437
+FS+ R V + + LG+++V G L I +L PA ++ A
Sbjct: 1059 NFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNA 1118
Query: 438 LSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPH 492
L GD++ ++G V L A+ AV K+ + + IV T +I H
Sbjct: 1119 LKTGDKILEVSG---VDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVH 1170
Score = 30.0 bits (66), Expect = 6.0
Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 395 VHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
+ LEK + GLG++L + S + V+ + GPA G + IGD L IN L G
Sbjct: 1240 IELEKDKN-GLGLSLAGNKDRSRMSIFVVG-INPEGPAAADGRMRIGDELLEINNQILYG 1297
Query: 455 LPLAACQAAVRETKSQTSV 473
A ++ S+ +
Sbjct: 1298 RSHQNASAIIKTAPSKVKL 1316
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 50.4 bits (119), Expect = 4e-06
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 23/140 (16%)
Query: 359 ESGIDPSQVGVH-PSPGACHLHNGDLDHFSNSDNCR-------------EVHLEKRRGEG 404
E+G P V H SP + + + +H + S N +V + ++ EG
Sbjct: 871 ENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEG 930
Query: 405 LGVALV------ESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLA 458
G ++ ESG +P I ++ G PA+R L +GDR+ A+NG S++ +P A
Sbjct: 931 FGFVIISSLNRPESGSTITVPHK-IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHA 989
Query: 459 ACQAAVRETKSQTSVTLSIV 478
+++ + SVTL I+
Sbjct: 990 DIVKLIKD--AGLSVTLRII 1007
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 16/96 (16%)
Query: 479 HCPPVTTAIIHRPHAREQLGFCVEDGI--------------ICSLLRGGIAER-GGIRVG 523
H + +IHR E GF + + I ++ G A+R ++VG
Sbjct: 914 HSLQTSDVVIHRKE-NEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVG 972
Query: 524 HRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMP 559
RI+ +NGQS++ PHA I++L+ +A V ++ +P
Sbjct: 973 DRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIP 1008
Score = 36.2 bits (82), Expect = 0.084
Identities = 22/45 (48%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 503 DGIICSLLRGGIAERGG-IRVGHRIIEINGQSVVATPHARIIELL 546
D + L G A R G +RVG +IIEING+S HAR IEL+
Sbjct: 1170 DLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI 1214
Score = 29.6 bits (65), Expect = 7.9
Identities = 12/29 (41%), Positives = 18/29 (62%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTS 451
+ L GPA R+G + +GD++ ING S
Sbjct: 1173 VLRLAEDGPAIRNGRMRVGDQIIEINGES 1201
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 50.4 bits (119), Expect = 4e-06
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 20/150 (13%)
Query: 363 DPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAV 422
D SQ + G+ L+ ++ +V L+++ EG G ++ S + P V
Sbjct: 820 DSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK--NKPPPGV 877
Query: 423 IAN----LLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
I + ++ G PA+R G L +GD ++A+NG S+V L +++ + +VTL+++
Sbjct: 878 IPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD--AGVTVTLTVI 935
Query: 479 -----HCPPVTT-------AIIHRPHAREQ 496
H PP T A+ HRP + Q
Sbjct: 936 AEEEHHGPPSGTNSARQSPALQHRPMGQSQ 965
Score = 34.3 bits (77), Expect = 0.32
Identities = 16/42 (38%), Positives = 27/42 (64%), Gaps = 1/42 (2%)
Query: 509 LLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTEA 549
++ G A+R G ++VG I +NGQS+V H I++L+ +A
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDA 926
Score = 32.7 bits (73), Expect = 0.93
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 512 GGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMP 559
G + G I VG +I+EING+ H R IEL+ +V + P
Sbjct: 1054 GPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRP 1101
Score = 29.6 bits (65), Expect = 7.9
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
+ N+L GPA + G ++ GD + ING ++G
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLG 467
Score = 29.6 bits (65), Expect = 7.9
Identities = 17/62 (27%), Positives = 27/62 (43%)
Query: 512 GGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQ 571
G A+ G I G I++ING V+ HA ++++ ++ Y L E
Sbjct: 443 GPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502
Query: 572 PV 573
PV
Sbjct: 503 PV 504
Score = 29.6 bits (65), Expect = 7.9
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 3/64 (4%)
Query: 392 CREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTS 451
C V LE R G G +L G I L GPA + G + +GD++ ING
Sbjct: 1019 CYPVELE-RGPRGFGFSL--RGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
Query: 452 LVGL 455
G+
Sbjct: 1076 TQGI 1079
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 50.4 bits (119), Expect = 4e-06
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 20/150 (13%)
Query: 363 DPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAV 422
D SQ + G+ L+ ++ +V L+++ EG G ++ S + P V
Sbjct: 820 DSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSK--NKPPPGV 877
Query: 423 IAN----LLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIV 478
I + ++ G PA+R G L +GD ++A+NG S+V L +++ + +VTL+++
Sbjct: 878 IPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD--AGVTVTLTVI 935
Query: 479 -----HCPPVTT-------AIIHRPHAREQ 496
H PP T A+ HRP + Q
Sbjct: 936 AEEEHHGPPSGTNSARQSPALQHRPMGQSQ 965
Score = 34.3 bits (77), Expect = 0.32
Identities = 16/42 (38%), Positives = 27/42 (64%), Gaps = 1/42 (2%)
Query: 509 LLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTEA 549
++ G A+R G ++VG I +NGQS+V H I++L+ +A
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDA 926
Score = 32.7 bits (73), Expect = 0.93
Identities = 17/48 (35%), Positives = 24/48 (50%)
Query: 512 GGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMP 559
G + G I VG +I+EING+ H R IEL+ +V + P
Sbjct: 1054 GPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRP 1101
Score = 29.6 bits (65), Expect = 7.9
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
+ N+L GPA + G ++ GD + ING ++G
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLG 467
Score = 29.6 bits (65), Expect = 7.9
Identities = 17/62 (27%), Positives = 27/62 (43%)
Query: 512 GGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQ 571
G A+ G I G I++ING V+ HA ++++ ++ Y L E
Sbjct: 443 GPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSED 502
Query: 572 PV 573
PV
Sbjct: 503 PV 504
Score = 29.6 bits (65), Expect = 7.9
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 3/64 (4%)
Query: 392 CREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTS 451
C V LE R G G +L G I L GPA + G + +GD++ ING
Sbjct: 1019 CYPVELE-RGPRGFGFSL--RGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
Query: 452 LVGL 455
G+
Sbjct: 1076 TQGI 1079
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 49.7 bits (117), Expect = 7e-06
Identities = 28/60 (46%), Positives = 38/60 (63%), Gaps = 2/60 (3%)
Query: 399 KRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLA 458
KR G LG+ + SG +I++L GG AER+GA+ IGDR+ AIN +SL G PL+
Sbjct: 625 KRYGGPLGITI--SGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLS 682
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 395 VHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
V L K+ LG+ + VI+++ G A R+G L +GD+L AI+ L
Sbjct: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
Query: 455 LPLAACQAAVRETKSQTSVTLSIVHC----PPVTTAIIHRPHAREQ---LGFCVEDG--- 504
+ +++ + + + + AII+ + LG +
Sbjct: 582 CSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP 641
Query: 505 ----IICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIK 556
II SL +GG+AER G I +G RI+ IN S+ P + I LL A V +K
Sbjct: 642 FDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLK 698
Score = 47.4 bits (111), Expect = 4e-05
Identities = 38/162 (23%), Positives = 69/162 (42%), Gaps = 20/162 (12%)
Query: 422 VIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLS----- 476
VI + GGPA+R G + GDRL +++G L+G A + +++ + ++ +
Sbjct: 181 VITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSV 240
Query: 477 ----IVHCPPVTTAIIHRPHAREQLGFCVEDGIICS--------LLRGGIAER-GGIRVG 523
P+ + P A LG + + C+ + IA+R G + VG
Sbjct: 241 MDSVATASGPLLVEVAKTPGA--SLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVG 298
Query: 524 HRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRL 565
I+ I+G S+ A + L +V ++ +P RL
Sbjct: 299 DHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRL 340
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/175 (25%), Positives = 77/175 (44%), Gaps = 24/175 (13%)
Query: 395 VHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVG 454
V L K+ G LG+ + SG ++NL GG A RS L +GD + A+NG +L
Sbjct: 54 VELMKKEGTTLGLTV--SGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
Query: 455 LPLAACQAAVRETKSQTSVTLSIVHCPPVT---TAIIHRP------HAREQLGFCVEDG- 504
+ ++ + + + PPV+ +++I R GF + G
Sbjct: 112 FRHDEIISLLKNVGERVVLEVE-YELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGA 170
Query: 505 ----------IICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTE 548
+I + GG A+R G I+ G R++ ++G ++ T HA + +L +
Sbjct: 171 HDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQ 225
Score = 38.1 bits (87), Expect = 0.022
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 19/146 (13%)
Query: 404 GLGVALVESGWGS--LLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQ 461
G G+ L S + + L +I+ + PAER G L IGDR+ AING
Sbjct: 430 GFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEAS 489
Query: 462 AAVRETKSQTSVTLSIVH------CPPVTTAIIHRPHARE-QLGFCVEDG---------I 505
+R++ + VTL I P T + P +LG + +
Sbjct: 490 QLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLV 549
Query: 506 ICSLLRGGIAER-GGIRVGHRIIEIN 530
I + +G +A R G + +G +++ I+
Sbjct: 550 ISDIKKGSVAHRTGTLELGDKLLAID 575
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 49.7 bits (117), Expect = 7e-06
Identities = 40/144 (27%), Positives = 66/144 (45%), Gaps = 12/144 (8%)
Query: 221 FGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTA 280
+ A++LGST++ + + + +K +G+ P +V+L +S +K+L
Sbjct: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIP--KVELQISIYGVKILEP 84
Query: 281 DSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAED-AQ 339
++E + LH IS+ AD +R+ K LC+VF +E A+
Sbjct: 85 KTKEVQHNCQLHRISFCADD------KTDKRIFTFICKDSESN---KHLCYVFDSEKCAE 135
Query: 340 LIAQAIGQAFAAAYSQFLRESGID 363
I IGQAF AY +FL G D
Sbjct: 136 EITLTIGQAFDLAYRKFLESGGKD 159
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 49.3 bits (116), Expect = 1e-05
Identities = 59/241 (24%), Positives = 99/241 (41%), Gaps = 51/241 (21%)
Query: 155 VEGASAEQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPETLASYPAPQEVPGP----- 209
+ A+ E+ G+R S S P L P P A A S P + +P P
Sbjct: 84 LSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGR-PGDEPLPRPPRGAP 142
Query: 210 -CDHEDLLDGVIFGARYLGSTQLV-SERNPPTSTRMAQAREAMDRV-------KAPDGET 260
+ L GV + +YLG +++ S R+ STR REA+ RV K +
Sbjct: 143 HASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKR 202
Query: 261 QPMTE-----------------VDLFVSTKRIKVLTADSQEAMMDHALHTISYTA----D 299
+P ++ + L +ST + + T DS++ + +H + +IS+ + D
Sbjct: 203 KPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPD 262
Query: 300 IGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAED--AQLIAQAIGQAFAAAYSQFL 357
+ +A+ + RR CH+ D AQ + +IGQAF + Q+L
Sbjct: 263 TTDYVAYVAKDPVNRR-------------ACHILECCDGLAQDVIGSIGQAFELRFKQYL 309
Query: 358 R 358
+
Sbjct: 310 Q 310
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 391 NCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGT 450
N V L KR+ GLG + E P +I++L+ GG AE+SG + GD + A+NG
Sbjct: 14 NVISVRLFKRKVGGLGFLVKER---VSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGR 70
Query: 451 SLVGLPLAACQAAVRETKSQTSVTL 475
LV L + +R S+T V L
Sbjct: 71 PLVDLSYDSALEVLRGIASETHVVL 95
Score = 37.0 bits (84), Expect = 0.049
Identities = 23/66 (34%), Positives = 36/66 (54%), Gaps = 7/66 (10%)
Query: 497 LGFCVEDG------IICSLLRGGIAERGG-IRVGHRIIEINGQSVVATPHARIIELLTEA 549
LGF V++ II L+RGG AE+ G I+ G I+ +NG+ +V + +E+L
Sbjct: 28 LGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGI 87
Query: 550 YGEVHI 555
E H+
Sbjct: 88 ASETHV 93
>gi|148612825 Rap GTPase interactor [Homo sapiens]
Length = 1075
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/71 (42%), Positives = 39/71 (54%), Gaps = 2/71 (2%)
Query: 387 SNSDNCREVHLEKRRG-EGLGVALVESGWGSL-LPTAVIANLLHGGPAERSGALSIGDRL 444
S D C +E RG GLG+ L++ L P I LL G PA G LS+GDR+
Sbjct: 967 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 1026
Query: 445 TAINGTSLVGL 455
+NG+SL+GL
Sbjct: 1027 LEVNGSSLLGL 1037
Score = 32.3 bits (72), Expect = 1.2
Identities = 57/238 (23%), Positives = 85/238 (35%), Gaps = 47/238 (19%)
Query: 19 EGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFEALPGDLVGPSPGG 78
E P I++PS+ D L LD+S Q L+ L G SPG
Sbjct: 771 ENPPPIVLPSDGFQVD------------LEANCLDDSIYQHLLYVRHFLWGLRSRASPGS 818
Query: 79 APCPLHIATGHGLASQEIADA---HGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPA 135
P G G ASQ + H +L G L CP + P +P
Sbjct: 819 PGRP-----GSG-ASQPVCPEGMHHVVLD---------GHLEAPSCPLA------PRDPG 857
Query: 136 PRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPE 195
P + + W + Q SR S + P ++ L+TP P G + +
Sbjct: 858 PAAREVAPERTLPLRGAPWAQAPPGRQP-SRGGSQAGPPHTDSSCLLTPPSTPLGPEPGD 916
Query: 196 TLASYPAPQEVPGPCDH---EDLLDGV--IFGARYLGSTQLVSERNPPTSTRMAQARE 248
P E GPC E +G+ + GA G + ++E +PP + + + E
Sbjct: 917 -----PDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTE 969
Score = 30.0 bits (66), Expect = 6.0
Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Query: 429 GGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAII 488
GGP ++ + L+ + G + G A + + S++S T C T +
Sbjct: 923 GGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDF--CYVFTVELE 980
Query: 489 HRPHAREQLGFCVEDGI----------ICSLLRGGIAERGG-IRVGHRIIEINGQSVVAT 537
P LG + DG+ I +LL G A G + +G RI+E+NG S++
Sbjct: 981 RGPSG---LGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGL 1037
Query: 538 PHARIIELL 546
+ R ++L+
Sbjct: 1038 GYLRAVDLI 1046
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/170 (25%), Positives = 74/170 (43%), Gaps = 24/170 (14%)
Query: 400 RRGEGLGVALVESG------WGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLV 453
R G LG+++V +G P I+ +L G A RSG L +GDR+ A+NG +
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 454 GLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCV------------ 501
+A+ + S+ + PP + + E+LG +
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Query: 502 ---EDGIICSLLR--GGIAERGGIRVGHRIIEINGQSVVATPHARIIELL 546
++GI S + G G +RVG R++E+N QS++ H ++LL
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 47.4 bits (111), Expect = 4e-05
Identities = 53/220 (24%), Positives = 77/220 (35%), Gaps = 67/220 (30%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTA-----VIANLLHGGPAERSGALSIGDRLTAI 447
R V R GLG ++ G GS A ++ + GG A R+G L +GDR+ +I
Sbjct: 860 RHVACLARSERGLGFSIA-GGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 448 NGTSLV---------------------------------GLPLAACQAAVRETKSQTSVT 474
NG + LP ++ A T S T+ T
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Query: 475 LSIVHCPPVTTAI-------------IHRPHAREQLGFCVEDG---------------II 506
+ P + ++ I P A LG + G I
Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
Query: 507 CSLLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELL 546
+L G+A R G+RVG RI+ +NGQ V H + L
Sbjct: 1039 SKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 40.8 bits (94), Expect = 0.003
Identities = 44/180 (24%), Positives = 70/180 (38%), Gaps = 54/180 (30%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVR----------------E 466
I+ + GPA R+G + +GD+L +NG +L G A+R E
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE 818
Query: 467 TKSQTSVT-----------------LSIVHCPPVTTAIIHRPH----AREQ--LGFCVED 503
++ ++T L + PP + + + H AR + LGF +
Sbjct: 819 PENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAG 878
Query: 504 G-------------IICSLLRGGIAERGG-IRVGHRIIEINGQSVVATPHARIIELLTEA 549
G + + GG A R G ++VG R++ ING V H + LLT A
Sbjct: 879 GKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA 938
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 502 EDGIICSLL-RGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIK 556
++GI S + G A R G+RVG +++E+NG ++ H +E L A V ++
Sbjct: 755 DEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMR 810
Score = 30.4 bits (67), Expect = 4.6
Identities = 62/261 (23%), Positives = 94/261 (36%), Gaps = 61/261 (23%)
Query: 8 RSPSGPPAMDLEGPRDI--------LVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQE 59
+ P PP+ D E P ++ VP+ D+ P GP + ++ S +E
Sbjct: 1302 QQPPSPPSPD-ELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASP----EQLSFRE 1356
Query: 60 LVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLL---------SAEAGRD 110
+ FE ++ P G P + + L + +A L +AEAG +
Sbjct: 1357 RQKYFEL---EVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAE 1413
Query: 111 DLLGL----LHCEE--------CPPSQTGPEEPLEPAP------------------RL-L 139
L L L EE PS T + P P P RL +
Sbjct: 1414 ARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRV 1473
Query: 140 QPPEDP-DEDSDSPEWVEGASAEQEG---SRSSSSSPEPWLETVPLVTPEEPPAGAQSP- 194
Q PE P E + SP + AE+ + S + L +++ + G + P
Sbjct: 1474 QSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPL 1533
Query: 195 ETLASYPAPQEVPGPCDHEDL 215
E LA P+P P P EDL
Sbjct: 1534 ERLAEAPSPAPTPSPTPVEDL 1554
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/170 (25%), Positives = 74/170 (43%), Gaps = 24/170 (14%)
Query: 400 RRGEGLGVALVESG------WGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLV 453
R G LG+++V +G P I+ +L G A RSG L +GDR+ A+NG +
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 454 GLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCV------------ 501
+A+ + S+ + PP + + E+LG +
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Query: 502 ---EDGIICSLLR--GGIAERGGIRVGHRIIEINGQSVVATPHARIIELL 546
++GI S + G G +RVG R++E+N QS++ H ++LL
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 47.4 bits (111), Expect = 4e-05
Identities = 53/220 (24%), Positives = 77/220 (35%), Gaps = 67/220 (30%)
Query: 393 REVHLEKRRGEGLGVALVESGWGSLLPTA-----VIANLLHGGPAERSGALSIGDRLTAI 447
R V R GLG ++ G GS A ++ + GG A R+G L +GDR+ +I
Sbjct: 860 RHVACLARSERGLGFSIA-GGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 448 NGTSLV---------------------------------GLPLAACQAAVRETKSQTSVT 474
NG + LP ++ A T S T+ T
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Query: 475 LSIVHCPPVTTAI-------------IHRPHAREQLGFCVEDG---------------II 506
+ P + ++ I P A LG + G I
Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
Query: 507 CSLLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELL 546
+L G+A R G+RVG RI+ +NGQ V H + L
Sbjct: 1039 SKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 40.8 bits (94), Expect = 0.003
Identities = 44/180 (24%), Positives = 70/180 (38%), Gaps = 54/180 (30%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVR----------------E 466
I+ + GPA R+G + +GD+L +NG +L G A+R E
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE 818
Query: 467 TKSQTSVT-----------------LSIVHCPPVTTAIIHRPH----AREQ--LGFCVED 503
++ ++T L + PP + + + H AR + LGF +
Sbjct: 819 PENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAG 878
Query: 504 G-------------IICSLLRGGIAERGG-IRVGHRIIEINGQSVVATPHARIIELLTEA 549
G + + GG A R G ++VG R++ ING V H + LLT A
Sbjct: 879 GKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA 938
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 502 EDGIICSLL-RGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIK 556
++GI S + G A R G+RVG +++E+NG ++ H +E L A V ++
Sbjct: 755 DEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMR 810
Score = 30.4 bits (67), Expect = 4.6
Identities = 62/261 (23%), Positives = 94/261 (36%), Gaps = 61/261 (23%)
Query: 8 RSPSGPPAMDLEGPRDI--------LVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQE 59
+ P PP+ D E P ++ VP+ D+ P GP + ++ S +E
Sbjct: 1302 QQPPSPPSPD-ELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASP----EQLSFRE 1356
Query: 60 LVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLL---------SAEAGRD 110
+ FE ++ P G P + + L + +A L +AEAG +
Sbjct: 1357 RQKYFEL---EVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAE 1413
Query: 111 DLLGL----LHCEE--------CPPSQTGPEEPLEPAP------------------RL-L 139
L L L EE PS T + P P P RL +
Sbjct: 1414 ARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRV 1473
Query: 140 QPPEDP-DEDSDSPEWVEGASAEQEG---SRSSSSSPEPWLETVPLVTPEEPPAGAQSP- 194
Q PE P E + SP + AE+ + S + L +++ + G + P
Sbjct: 1474 QSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPL 1533
Query: 195 ETLASYPAPQEVPGPCDHEDL 215
E LA P+P P P EDL
Sbjct: 1534 ERLAEAPSPAPTPSPTPVEDL 1554
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 48.9 bits (115), Expect = 1e-05
Identities = 50/221 (22%), Positives = 78/221 (35%), Gaps = 68/221 (30%)
Query: 394 EVHLEKRRGEGLGVALVES----------GWGSLLPTAVIANLLHGGPAERSGALSIGDR 443
+V + + EG G +V S G + I ++ G PA+R G L +GDR
Sbjct: 970 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
Query: 444 LTAINGTSLVG---------------------LPLAACQAAVRETKSQTSVTLSIVHCP- 481
+ A+NG S+ +P A T ++ T++ H P
Sbjct: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
Query: 482 -----------------------PVTTA-----IIHRPHAREQLGFCVEDG-------II 506
P T + + GF + G +
Sbjct: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1149
Query: 507 CSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELL 546
L G AER G +R+G I+EING++ H+R IEL+
Sbjct: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1190
Score = 39.3 bits (90), Expect = 0.010
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 6/95 (6%)
Query: 483 VTTAIIHRPHAREQLG-FCVE-DGIICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPH 539
V + + RP A G CV I ++ G A+R G ++VG RI+ +NG S+ H
Sbjct: 984 VIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1043
Query: 540 ARIIELLTEAYGEVHIKTMP---AATYRLLTGQEQ 571
+ I+ L+ EA V ++ +P ++ LLT E+
Sbjct: 1044 SDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK 1078
Score = 29.6 bits (65), Expect = 7.9
Identities = 19/73 (26%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 423 IANLLHGGPAERSGALSIGDRLTAINGTSLVG----LPLAACQAAVRETKSQTSVTLSIV 478
I +++ G A+ G L GD L ++GT ++G L + Q A ++ +V +V
Sbjct: 839 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV 898
Query: 479 HCPPVTTAIIHRP 491
P T + P
Sbjct: 899 FAVPKTENEVPSP 911
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 48.9 bits (115), Expect = 1e-05
Identities = 50/221 (22%), Positives = 78/221 (35%), Gaps = 68/221 (30%)
Query: 394 EVHLEKRRGEGLGVALVES----------GWGSLLPTAVIANLLHGGPAERSGALSIGDR 443
+V + + EG G +V S G + I ++ G PA+R G L +GDR
Sbjct: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
Query: 444 LTAINGTSLVG---------------------LPLAACQAAVRETKSQTSVTLSIVHCP- 481
+ A+NG S+ +P A T ++ T++ H P
Sbjct: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
Query: 482 -----------------------PVTTA-----IIHRPHAREQLGFCVEDG-------II 506
P T + + GF + G +
Sbjct: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1177
Query: 507 CSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELL 546
L G AER G +R+G I+EING++ H+R IEL+
Sbjct: 1178 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
Score = 39.3 bits (90), Expect = 0.010
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 6/95 (6%)
Query: 483 VTTAIIHRPHAREQLG-FCVE-DGIICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPH 539
V + + RP A G CV I ++ G A+R G ++VG RI+ +NG S+ H
Sbjct: 1012 VIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1071
Query: 540 ARIIELLTEAYGEVHIKTMP---AATYRLLTGQEQ 571
+ I+ L+ EA V ++ +P ++ LLT E+
Sbjct: 1072 SDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK 1106
Score = 34.3 bits (77), Expect = 0.32
Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 12/132 (9%)
Query: 371 PSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLL-------PTAVI 423
PSP A L G+ + NS N E + + + + + E+G+G + I
Sbjct: 809 PSP-ASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYI 867
Query: 424 ANLLHGGPAERSGALSIGDRLTAINGTSLVG----LPLAACQAAVRETKSQTSVTLSIVH 479
+++ G A+ G L GD L ++GT ++G L + Q A ++ +V +V
Sbjct: 868 GHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 927
Query: 480 CPPVTTAIIHRP 491
P T + P
Sbjct: 928 AVPKTENEVPSP 939
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 48.5 bits (114), Expect = 2e-05
Identities = 50/222 (22%), Positives = 78/222 (35%), Gaps = 69/222 (31%)
Query: 394 EVHLEKRRGEGLGVALVES-----------GWGSLLPTAVIANLLHGGPAERSGALSIGD 442
+V + + EG G +V S G + I ++ G PA+R G L +GD
Sbjct: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1057
Query: 443 RLTAINGTSLVG---------------------LPLAACQAAVRETKSQTSVTLSIVHCP 481
R+ A+NG S+ +P A T ++ T++ H P
Sbjct: 1058 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1117
Query: 482 ------------------------PVTTA-----IIHRPHAREQLGFCVEDG-------I 505
P T + + GF + G
Sbjct: 1118 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1177
Query: 506 ICSLLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELL 546
+ L G AER G +R+G I+EING++ H+R IEL+
Sbjct: 1178 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1219
Score = 38.5 bits (88), Expect = 0.017
Identities = 22/67 (32%), Positives = 39/67 (58%), Gaps = 4/67 (5%)
Query: 509 LLRGGIAER-GGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMP---AATYR 564
++ G A+R G ++VG RI+ +NG S+ H+ I+ L+ EA V ++ +P ++
Sbjct: 1041 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1100
Query: 565 LLTGQEQ 571
LLT E+
Sbjct: 1101 LLTNAEK 1107
Score = 34.3 bits (77), Expect = 0.32
Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 12/132 (9%)
Query: 371 PSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLL-------PTAVI 423
PSP A L G+ + NS N E + + + + + E+G+G + I
Sbjct: 809 PSP-ASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYI 867
Query: 424 ANLLHGGPAERSGALSIGDRLTAINGTSLVG----LPLAACQAAVRETKSQTSVTLSIVH 479
+++ G A+ G L GD L ++GT ++G L + Q A ++ +V +V
Sbjct: 868 GHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 927
Query: 480 CPPVTTAIIHRP 491
P T + P
Sbjct: 928 AVPKTENEVPSP 939
>gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
Length = 817
Score = 47.8 bits (112), Expect = 3e-05
Identities = 77/356 (21%), Positives = 125/356 (35%), Gaps = 54/356 (15%)
Query: 119 EECPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLET 178
E CP Q P+ + PA +PP P E ++ E+ G + S+P ++
Sbjct: 270 ERCPAGQQPPQHRVAPA----RPPPKPREVRK----IKPVEVEESGESEAESAPGEVIQA 321
Query: 179 VPLVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPP 238
VT + T AS PAP+E E V R +G+ R P
Sbjct: 322 E--VTVHAALENGSTVATAAS-PAPEEPKAQAAPEKEAAAVAPPERGVGNG-----RAPD 373
Query: 239 TSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTA 298
A E +D K D + +V + +A ++ D Y
Sbjct: 374 V------APEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEEDGEPPYEP 427
Query: 299 DIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLR 358
+ GCV + P+ + H + + ED Y + R
Sbjct: 428 ESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNED---------------YDR--R 470
Query: 359 ESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLL 418
+DP +L+ V LEK EGLG++++ G G+ +
Sbjct: 471 NEDVDPMAASAEY----------ELEKRVERLELFPVELEKD-SEGLGISIIGMGAGADM 519
Query: 419 PTA----VIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQ 470
+ + GG A R G + + D L ++GTSLVG+ + + +R TK +
Sbjct: 520 GLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGR 575
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,050,564
Number of Sequences: 37866
Number of extensions: 1548834
Number of successful extensions: 9622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 438
Number of HSP's that attempted gapping in prelim test: 7999
Number of HSP's gapped (non-prelim): 1870
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.