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Search of human proteins with 20270337
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20270337 Leo1, Paf1/RNA polymerase II complex component,
homolog [Homo sapiens]
(666 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 1344 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 136 5e-32
gi|217330641 IWS1 homolog [Homo sapiens] 119 1e-26
gi|16445033 ACRC protein [Homo sapiens] 97 4e-20
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 90 8e-18
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 89 1e-17
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 85 2e-16
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 85 2e-16
gi|24415404 MDN1, midasin homolog [Homo sapiens] 83 9e-16
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 80 6e-15
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 80 6e-15
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 78 3e-14
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 76 9e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 74 6e-13
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 74 6e-13
gi|4504487 histidine rich calcium binding protein precursor [Hom... 73 7e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 72 2e-12
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 71 4e-12
gi|60097902 filaggrin [Homo sapiens] 70 8e-12
gi|210032580 SET domain containing 1B [Homo sapiens] 70 8e-12
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 69 1e-11
gi|148746195 trichohyalin [Homo sapiens] 69 2e-11
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 67 5e-11
gi|7657138 golgi integral membrane protein 4 [Homo sapiens] 67 7e-11
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 67 7e-11
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 67 7e-11
gi|190194423 SPARC-like 1 [Homo sapiens] 65 2e-10
gi|190341024 SPARC-like 1 [Homo sapiens] 65 2e-10
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 65 2e-10
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 65 2e-10
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 1344 bits (3478), Expect = 0.0
Identities = 666/666 (100%), Positives = 666/666 (100%)
Query: 1 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE
Sbjct: 1 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG
Sbjct: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD
Sbjct: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
Query: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 240
DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE
Sbjct: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 240
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 300
EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS
Sbjct: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 300
Query: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 360
DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV
Sbjct: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 360
Query: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 420
EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI
Sbjct: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 420
Query: 421 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 480
RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ
Sbjct: 421 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 480
Query: 481 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 540
GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE
Sbjct: 481 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 540
Query: 541 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 600
ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE
Sbjct: 541 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 600
Query: 601 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 660
ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE
Sbjct: 601 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 660
Query: 661 EEEDDD 666
EEEDDD
Sbjct: 661 EEEDDD 666
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 136 bits (343), Expect = 5e-32
Identities = 90/325 (27%), Positives = 137/325 (42%), Gaps = 16/325 (4%)
Query: 12 ADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
+DS + SDS SDSD +++ SN++ S+SD DS SN DS D
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS----DSSDSSD 748
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSE 131
S +S + S S N S++S+ SD D+ S S + + D + S S+ S+
Sbjct: 749 SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD 808
Query: 132 AEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE----ERAQGSDEDKLQNSDDDEKMQN 187
+ S + SD + D S+ SD NS D + + GSD D SD +
Sbjct: 809 SSDSSDS-SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDS 867
Query: 188 TDDEERPQLSDDERQQLSEEEKANSDDE---RPVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
+D + SD S E +SD SD+ D +SD + SD +
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
NS D + S D + + S+S+ SDS + ++ +SDS SD+
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987
Query: 305 PKDNSGTMDLFGGADDISSGSDGED 329
D+S + D + D S+ SD D
Sbjct: 988 SSDSSDSSD----SSDSSNSSDSSD 1008
Score = 134 bits (337), Expect = 3e-31
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 18/337 (5%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
+D D SD+ + ++ +S SDS + +++ S ++ GS+SD R DS S+
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS- 868
Query: 62 FGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGH 121
DS D S S + S S N S++S+ S+ D+D SD S S ++ D
Sbjct: 869 ---DSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Query: 122 RSDGGSHHSEAEGSEKAHSDD--EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNS 179
S+ + + ++ S + S D + D S+ SD +S D + SD +S
Sbjct: 926 SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985
Query: 180 DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDD-----ERPVASDNDDEKQNSDDEEQ 234
D ++ D S D + +NS D + +SD+ D +SD +
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS 1045
Query: 235 PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS 294
SD NS D + + S D + SES+ SDS + ++ +S
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS-----SDSSDSS 1100
Query: 295 DSEADSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
DS SD+ D+S + D +D D S SD D
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1137
Score = 134 bits (336), Expect = 4e-31
Identities = 90/345 (26%), Positives = 144/345 (41%), Gaps = 14/345 (4%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ + ++ +S SDS+S + +S S+ S SD + DS SN D S+
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHED----NDPSDVDQHSGSEAPNDDEDEGHRSDG 125
+S+ S S N S+ S N S++S+ SD D +D SD S S +D D SD
Sbjct: 1014 DSSNSSDSSNSSD-SSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072
Query: 126 GSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
++ SE + S D D SD SD +SD + + SD NS D
Sbjct: 1073 SDSSDSSDSSESSDSSDSS-NSSDSSDSSDSS--DSSDSSDSSDSSDSSDSSNSSDSSDS 1129
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
++ D S D + ++S D +SD+ D +SD + SD +
Sbjct: 1130 SDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD-SSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 246 SDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVP 305
S D + + S D + S+S+ SDS D ++ +++S SD+
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSNESSDSSDSSDS 1243
Query: 306 KDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEE 350
D+S + D +D S SD D+ + + + N D +
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSD 1288
Score = 132 bits (333), Expect = 8e-31
Identities = 98/341 (28%), Positives = 152/341 (44%), Gaps = 26/341 (7%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ S++ + +SDS SDSD ++ +S SN+S S SD + DS SN D S+
Sbjct: 620 SDSKSDSSKSESDS---SDSDSKSDSSDSNSSDS-SDNSDSSDSSNSSNSSDSSDSSDSS 675
Query: 70 GASHHSGSDNHSERSD-----NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD 124
+S S S N S+ SD N SE+S+ SD D+D SD S S + + D S
Sbjct: 676 DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Query: 125 GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDD-EKIQNSDDEERAQGSDEDKLQNSDDDE 183
S+ S++ S + + + D S+ SD + +SD + + SD + NS D
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 184 KMQNTDDEERPQLSDDERQQLSEEEKANSDD--------ERPVASDNDDEKQNSD--DEE 233
N+ D S D S+ + +NS D + +SD+ D +SD D +
Sbjct: 796 DSSNSSDSSNSSDSSDSSDS-SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 234 QPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIA 293
SD +S D ++ + S D E + S+S+ S+S D ++ +
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 294 SDSEADSDTEV---PKDNSGTMDLFGGAD--DISSGSDGED 329
SDS SD+ DNS + D +D D S S+ D
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD 955
Score = 132 bits (332), Expect = 1e-30
Identities = 93/335 (27%), Positives = 142/335 (42%), Gaps = 23/335 (6%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ + ++ SDS + SDS + +S S+ S + SD DS S+ D S
Sbjct: 895 SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS 954
Query: 70 GASHHSGSDNHSERSD----------NRSEASERSDHEDN-DPSDVDQHSGSEAPNDDED 118
+S+ S S N S+ SD N S++S+ SD D+ D SD S S +D D
Sbjct: 955 DSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014
Query: 119 EGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDE--DKL 176
+ SD + + S+ + S D D SD SD NS D + S + D
Sbjct: 1015 SSNSSDSSNSSDSSNSSDSSDSSDSS-DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073
Query: 177 QNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQ 236
+SD + +++D + SD S + +SD +SD+ D +SD +
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSD--SSDSSDSSNSSDSSDSSD 1131
Query: 237 LSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDS 296
SD NS D + + S D + S+S+ SDS D ++ +SDS
Sbjct: 1132 SSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSNSSDSSDS 1186
Query: 297 EADSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
SD+ D+S + D +D D S SD D
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1221
Score = 132 bits (331), Expect = 1e-30
Identities = 91/329 (27%), Positives = 133/329 (40%), Gaps = 21/329 (6%)
Query: 12 ADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
+DS SDS SDS + +S S+ S SD DS SN D S +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803
Query: 72 SHHSGSDNHSERSD----NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
S+ S S + S+ SD N S++S SD D+ S S + D D +RSD +
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863
Query: 128 HHSEAEGSEKAHSDDEKWGRE-----DKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
++ S+ ++S D + + SD SD +SD + + SD NS D
Sbjct: 864 SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 923
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
+ N+ D S + + +NS D S N + NS D SD
Sbjct: 924 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD-----SSNSSDSSNSSDSSDSNSSDSSD 978
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
NS D + + S D + + S+S+ SDS D N+ SDS SD+
Sbjct: 979 SSNSSDSSDSSDSSD---SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS--SDSSNSSDS 1033
Query: 303 EVPKDNSGTMDLFGGAD--DISSGSDGED 329
D+S + D +D D S+ SD D
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1062
Score = 131 bits (329), Expect = 2e-30
Identities = 86/332 (25%), Positives = 151/332 (45%), Gaps = 24/332 (7%)
Query: 11 DADSEAERKDSDSGS---DSDSDQENAASGSNASGSESDQDE------RGDSGQPSNKEL 61
DA+SE++ S G +SD ++N +GS++ G+E D + DS N
Sbjct: 476 DANSESDNNSSSRGDASYNSDESKDNG-NGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN 534
Query: 62 FGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGH 121
+D D G SD+ S S N S++S+ SD + +D + S++ + D +
Sbjct: 535 DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594
Query: 122 RSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD 181
SD + ++ S+ + S D + KSD S E +SD + ++ SD + +SD+
Sbjct: 595 SSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES-DSSDSDSKSDSSDSNSSDSSDN 653
Query: 182 DEKMQNTDDEERPQLSD--DERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSD 239
+ +++ SD D S + +NS D +SD+ D +S+ + SD
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSD----SSDSSDSSNSSESSDSSDSSD 709
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAD 299
+ +SD +SD + +S D + + S+S+ SDS + ++ +SDS
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN-----SSDSSDSSDSSNS 764
Query: 300 SDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
SD+ D+S + D +D D S+ SD D
Sbjct: 765 SDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Score = 131 bits (329), Expect = 2e-30
Identities = 92/344 (26%), Positives = 142/344 (41%), Gaps = 25/344 (7%)
Query: 6 DLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDD 65
D SD+ + DS SDSDS N++S S++S S+S DS SN D
Sbjct: 548 DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607
Query: 66 SEDEGASHHSGS----------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPND 115
S+ +S S S ++ S SD++S++S+ + + +D SD S S +D
Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD 667
Query: 116 DEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGRE--DKSDQSDDEKIQNSDDEERAQGSDE 173
D SD S + S+ + S D E D SD SD + +S D + SD
Sbjct: 668 SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS-SDSSDSSNSNSSDS 726
Query: 174 DKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDD-ERPVASDNDDEKQNSDDE 232
D +SD + ++D + S+ S + +SD + +SD+ D +SD
Sbjct: 727 DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786
Query: 233 EQPQLSDEEKMQNSDD--------ERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVL 284
+ SD NS D + +SD + +S D S+S+ SDS D
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS-- 844
Query: 285 RMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGE 328
+ SDS SD+ D+S + D +D S E
Sbjct: 845 -SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Score = 130 bits (327), Expect = 4e-30
Identities = 90/332 (27%), Positives = 147/332 (44%), Gaps = 9/332 (2%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSD-SDQENAASGSNASGSESDQDERGDSGQPSNKE 60
+D + S S+++ DS+S SDSD SD +++ S + S S+ + DS S+
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS 614
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
D S+ + S S SD S SD++S++S+ + + +D SD S S +D D
Sbjct: 615 DSSDSSDSKSDSSKSESD--SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS 672
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGRE--DKSDQSDDEKIQNSDDEERAQGSDEDKLQN 178
SD S + S+ + S D E D SD SD + +S D + SD D +
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS-SDSSDSSNSNSSDSDSSNS 731
Query: 179 SDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSD-DERPVASDNDDEKQNSDDEEQPQL 237
SD + ++D + S+ S + +SD + +SD+ D +SD +
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS 791
Query: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
SD NS D +SD + + + S+S+ SDS D ++ S
Sbjct: 792 SDSSDSSNSSDS-SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG 850
Query: 298 ADSDTEVPKDNSGTMDLFGGADDISSGSDGED 329
+DSD+ D+S + D + D S+ SD D
Sbjct: 851 SDSDSSNRSDSSNSSD-SSDSSDSSNSSDSSD 881
Score = 129 bits (323), Expect = 1e-29
Identities = 87/333 (26%), Positives = 140/333 (42%), Gaps = 25/333 (7%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
+++ + ++ DS + SDSDS + +S S+ S + SD E +S SN DS +
Sbjct: 886 NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS----DSSNS 941
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHH 129
S S ++S S N S++S SD D++ SD S S +D D SD
Sbjct: 942 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001
Query: 130 SEAEGSEKAHSDD-----------EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQN 178
+ ++ S+ + S D + D SD SD +SD + + SD +
Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSS--DSSDSSDSSDSSDSSNSSD 1059
Query: 179 SDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLS 238
S D ++ D S D + + +NS D +SD+ D +SD + S
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD-SSDSSDSSDSSDSSDSSDSS 1118
Query: 239 DEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEA 298
D +S D + + +S D + S+S+ SDS D ++ +SDS
Sbjct: 1119 DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD-----SSDSSDSSDSSD 1173
Query: 299 DSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
SD+ D+S + D +D D S SD D
Sbjct: 1174 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206
Score = 128 bits (321), Expect = 2e-29
Identities = 95/340 (27%), Positives = 145/340 (42%), Gaps = 28/340 (8%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ ++ DSDS + SDS + +S S+ S + SD + DS + SN DS +
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS-DSSDSSNS 900
Query: 70 GASHHSGSDNHSERSD--NRSEASERSDHEDN----------DPSDVDQHSGSEAPNDDE 117
S S S N S+ SD N S++SE S+ DN D SD S S ++
Sbjct: 901 SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS 960
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE----ERAQGSDE 173
D + SD +S ++ S+ ++S D D SD SD NS D + + S+
Sbjct: 961 DSSNSSDSSDSNS-SDSSDSSNSSDSS-DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 174 DKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDD--ERPVASDNDDEKQNSDD 231
NS D ++ D S D + +NS D + +SD+ D +SD
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1078
Query: 232 EEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNA 291
+ + SD NS D + + S D + S+S+ SDS D ++
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD-----SSDSS 1133
Query: 292 IASDSEADSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
+SDS SD+ ++S + D +D D S SD D
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173
Score = 127 bits (319), Expect = 3e-29
Identities = 88/324 (27%), Positives = 136/324 (41%), Gaps = 11/324 (3%)
Query: 9 GSDADSE-AERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
G+ +DS+ AE DSDS SD+++ N + ++ +G S + +S
Sbjct: 502 GNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSS 561
Query: 68 DEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
D S S S + + SD+ S S+ SD D+D SD S S +D D SD
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621
Query: 128 HHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSD-EDKLQNSDDDEKMQ 186
S++ SE SD + + D SD + + NSD + + S+ D +SD +
Sbjct: 622 SKSDSSKSESDSSDSD--SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSS 679
Query: 187 NTDDEERPQLSDDERQQLSEEEKANSDDERPVASD-NDDEKQNSDDEEQPQLSDEEKMQN 245
++D SD S E +SD +SD +D NS D + SD N
Sbjct: 680 SSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN 739
Query: 246 SDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVP 305
S D + S D + + S+S+ SDS D ++ +SDS S++
Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD-----SSDSSNSSDSNDSSNSSDS 794
Query: 306 KDNSGTMDLFGGADDISSGSDGED 329
D+S + D + D S SD D
Sbjct: 795 SDSSNSSD-SSNSSDSSDSSDSSD 817
Score = 127 bits (319), Expect = 3e-29
Identities = 82/322 (25%), Positives = 141/322 (43%), Gaps = 9/322 (2%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G++ + + ++ DS G SD +++ S +++ S+S + DS S+ + DS D
Sbjct: 530 GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
S S S N S+ SD+ S++S+ SD D+ S D S SE+ + D D S +
Sbjct: 590 SSDSDSSDSSNSSDSSDS-SDSSDSSDSSDSSDSKSDS-SKSESDSSDSDSKSDSSDSNS 647
Query: 129 HSEAEGSEKAHSDDEKWGREDKSDQSD-DEKIQNSDDEERAQGSDEDKLQNSDDDEKMQN 187
++ S+ + S + D SD SD + +SD + SD NS + +
Sbjct: 648 SDSSDNSDSSDSSNSS-NSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSD 706
Query: 188 TDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSD 247
+ D + SD S+ + +NS D +S++ D +SD SD NS
Sbjct: 707 SSDSDSSDSSDSSNSNSSDSDSSNSSDSSD-SSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
Query: 248 DERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKD 307
D + + S + + + S S+ SDS + ++ S +DSD+ D
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825
Query: 308 NSGTMDLFGGADDISSGSDGED 329
+S + D + D S+ SD D
Sbjct: 826 SSNSSD----SSDSSNSSDSSD 843
Score = 126 bits (317), Expect = 6e-29
Identities = 86/351 (24%), Positives = 141/351 (40%), Gaps = 20/351 (5%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
S++ + DS SDS + +++ S +++ S+S DS SN D S+
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHH 129
+S S S N S+ SD+ + + + ++ SD S S +D D SD
Sbjct: 993 DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 130 SEAEGSEKAHSDD--EKWGREDKSDQSDDEKIQNSDDEERAQGSDE--DKLQNSDDDEKM 185
+ S+ + S D + D SD SD + +S D + S + D +SD +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 186 QNTDDEERPQLSD--DERQQLSEEEKANSDD-----ERPVASDNDDEKQNSDDEEQPQLS 238
++D + SD D + +NS D E +SD+ D +SD + S
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172
Query: 239 DEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEA 298
D NS D + + S D + S+S+ SDS D ++ +SDS
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSSDSSD 1227
Query: 299 DSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQE 349
SD+ D+S + D + D S+ SD D + D N Q +
Sbjct: 1228 SSDSNESSDSSDSSD----SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSK 1274
Score = 126 bits (316), Expect = 7e-29
Identities = 84/332 (25%), Positives = 143/332 (43%), Gaps = 13/332 (3%)
Query: 6 DLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSE-----SDQDERGDSGQPSNK- 59
D S++ S+++ DSDS SDSD ++++ S++S S SD + DS S+K
Sbjct: 570 DSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS 629
Query: 60 ELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE 119
E DS+ + S S S + S+ SD+ ++ + + +D SD S S ++ D
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689
Query: 120 GHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNS 179
SD + ++ S+ + SD S+ SD + +SD + + SD +S
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Query: 180 DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDD--ERPVASDNDDEKQNSDDEEQPQL 237
+ ++ D S D + +NS D + +SD+ D +SD
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
SD +SD S SD D S+S+ SD D + ++ +SDS
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD-SSDSSDSSDGSDSDSSNRSDSSNSSDSS 868
Query: 298 ADSDTEVPKDNSGTMDLFGGADDISSGSDGED 329
SD+ D+S + D +++ S+ SD D
Sbjct: 869 DSSDSSNSSDSSDSSD----SNESSNSSDSSD 896
Score = 126 bits (316), Expect = 7e-29
Identities = 86/329 (26%), Positives = 141/329 (42%), Gaps = 25/329 (7%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ + ++ DS SDSDS + +S S+ S S+ + DS S+ G DS+
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD----GSDSDSS 856
Query: 70 GASHHSGSDNHSERSD--NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
S S S + S+ SD N S++S+ SD ++ S S + + +D D + SD
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 128 HHSEAEGSEKAHSDD-----EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
+ ++ SE ++S D + D SD SD +S + + S + NS D
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
N+ D S D + +NS D +SD+ D +S+ + SD
Sbjct: 977 SDSSNSSDSSD---SSDSSDSSDSSDSSNSSD----SSDSSDSSDSSNSSDSSNSSDSSN 1029
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
+S D + + S D + + S+S+ SDS D ++ +SDS S++
Sbjct: 1030 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD-----SSDSSDSSDSSDSSES 1084
Query: 303 EVPKDNSGTMDLFGGAD--DISSGSDGED 329
D+S + D +D D S SD D
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1113
Score = 125 bits (315), Expect = 1e-28
Identities = 88/335 (26%), Positives = 145/335 (43%), Gaps = 11/335 (3%)
Query: 2 ADMEDLFGSDADSEAERKDS-DSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
+D D SD+ ++ DS +S + SDS + +S S++S S+ + DS SN
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 61 LFGD--DSEDEGASHHSGSDNHSERSDNRSEASERSDHED-NDPSDVDQHSGSEAPNDDE 117
D DS D +S S S N + + S +S+ SD + +D SD S S +D
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 759
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDD--EKWGREDKSDQSDDEKIQN-SDDEERAQGSDED 174
D + SD ++ S+ ++S D + D SD S+ N SD + + SD D
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819
Query: 175 KLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
+SD ++D SD + +++ + +SD+ D +S+ +
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 235 PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS 294
SD + NS D ++ + SD D S+S+ SDS + N+ +S
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSD-SSDSSNSSDSSES--SNSSDNSNSS 936
Query: 295 DSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED 329
DS SD+ D+S + D + D S+ SD D
Sbjct: 937 DSSNSSDSSDSSDSSNSSD-SSNSSDSSNSSDSSD 970
Score = 125 bits (314), Expect = 1e-28
Identities = 89/341 (26%), Positives = 142/341 (41%), Gaps = 25/341 (7%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
+D D SD+ + ++ DS SDS +++ S S++S SESD + DS S+
Sbjct: 588 SDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSD-SDSKSDSSDSN 646
Query: 62 FGDDSEDEGASHHSGSDNHSERSDNR--------SEASERSDHEDNDPSDVDQHSGSEAP 113
D S++ +S S S N S+ SD+ S++S SD D+ S S +
Sbjct: 647 SSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSD 706
Query: 114 NDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE-ERAQGSD 172
+ D D SD + +S S + + D SD SD +S D + + SD
Sbjct: 707 SSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSD 766
Query: 173 EDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDE 232
+S D N+ D S D + + +NS D + +D + NS D
Sbjct: 767 SSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDS 826
Query: 233 EQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
SD NS D +SD + + ++S+S+ SDS D ++
Sbjct: 827 SNS--SDSSDSSNSSD----SSDSSDSSDGSDSDSSNRSDSSNSSDSSD-----SSDSSN 875
Query: 293 ASDSEADSDTEVPKDNSGTMDLFGGAD----DISSGSDGED 329
+SDS SD+ ++S + D +D D S+ SD D
Sbjct: 876 SSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Score = 125 bits (314), Expect = 1e-28
Identities = 96/351 (27%), Positives = 152/351 (43%), Gaps = 34/351 (9%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
+D D SD+ + SDS S + SD ++++ S++S S SD DS S+
Sbjct: 705 SDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS-SDSSNSSDSSDSSDSSN 763
Query: 62 FGDDSEDEGASHHSGSDNHSERSD--NRSEASERSDHED----------NDPSDVDQHSG 109
D S+ +S S S N S+ +D N S++S+ S+ D +D SD D +
Sbjct: 764 SSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNS 823
Query: 110 SEAPN--DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSD-DEKIQNSDDEE 166
S++ N D D + SD ++G SD + R D S+ SD + +S+ +
Sbjct: 824 SDSSNSSDSSDSSNSSDSSDSSDSSDG-----SDSDSSNRSDSSNSSDSSDSSDSSNSSD 878
Query: 167 RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEK 226
+ SD ++ NS D N+ D + S D + +NS D +S++ D
Sbjct: 879 SSDSSDSNESSNSSDSSDSSNSSDSD----SSDSSNSSDSSDSSNSSDSSE-SSNSSDNS 933
Query: 227 QNSDDEEQPQLSDEEKMQNSDD-----ERPQASDEEHRHSDDEEEQDHKSESARGSDSED 281
+SD SD NS D + +SD +S D + + S+S+ SDS D
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD 993
Query: 282 EVLRMKRKNAI-ASDSEADSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
N+ +SDS SD+ D+S + D +D D S SD D
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD 1044
Score = 125 bits (314), Expect = 1e-28
Identities = 87/333 (26%), Positives = 139/333 (41%), Gaps = 12/333 (3%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
+D D SD+ + DS SDS SD +++ SN+S S SD + DS S+
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDS-SDSSDSSDSSNSSDS-SDSSDSSDSSNSSDSSN 1023
Query: 62 FGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGH 121
D S +S S S + S+ SD+ + + + +D SD S S +D D
Sbjct: 1024 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSE 1083
Query: 122 RSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDE--DKLQNS 179
SD + ++ S+ + S D D SD SD NS D + S + D +S
Sbjct: 1084 SSDSSDSSNSSDSSDSSDSSDSS-DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142
Query: 180 DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLS 238
D + +++D + SD S + +SD +SD+ D +SD + S
Sbjct: 1143 DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202
Query: 239 DEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEA 298
D +S D + + S D + + S+S+ SDS D ++ +SDS
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSD-----SSNSSDSSDSSD 1257
Query: 299 DSD-TEVPKDNSGTMDLFGGADDISSGSDGEDK 330
SD T D S + G ++ S SD + +
Sbjct: 1258 SSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSE 1290
Score = 124 bits (312), Expect = 2e-28
Identities = 89/348 (25%), Positives = 143/348 (41%), Gaps = 24/348 (6%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD+ + ++ DS+S SDS + +S S+ S SD + +S S+ D S
Sbjct: 960 SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSS 1019
Query: 70 GASHHSGSDNHSERSDNR-----SEASERSDHED-NDPSDVDQHSGSEAPNDDEDEGHRS 123
+S+ S S N S+ SD+ S++S+ SD D ++ SD S S +D D S
Sbjct: 1020 DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSD-DEKIQNSDDEERAQGSDEDKLQNSDDD 182
D ++ S + S D D SD SD + +SD + + SD +S D
Sbjct: 1080 DSSESSDSSDSSNSSDSSDS----SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1135
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
N+ D S D + ++S D +SD+ D +S+ + SD
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDSSD----SSDSSDSSDSSNSSDSSDSSDSSD 1191
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
+S D + + S D + S+S+ SDS D +++ +SDS SD+
Sbjct: 1192 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SNESSDSSDSSDSSDS 1246
Query: 303 EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEE 350
D+S + D D + SD + K + NG D E
Sbjct: 1247 SNSSDSSDSSDSSDSTSDSNDESDSQSKSGNG----NNNGSDSDSDSE 1290
Score = 124 bits (310), Expect = 4e-28
Identities = 85/329 (25%), Positives = 146/329 (44%), Gaps = 16/329 (4%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNAS-GSESDQDERGDSGQPSNKELFGDDSED 68
SD+ + ++ DS + SDS SD N++ SN+S S+S DS S+ D S+
Sbjct: 777 SDSSNSSDSNDSSNSSDS-SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835
Query: 69 EGASHHSGSDNHSERSD----NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD 124
+S S S + S+ SD NRS++S SD D+ S S + +++ S
Sbjct: 836 SNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895
Query: 125 GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGS--DEDKLQNSDDD 182
S+ S+++ S+ ++S D D S+ SD + NS D + S D +SD
Sbjct: 896 DSSNSSDSDSSDSSNSSDS----SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS 951
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
+++ + SD S+ +++ + +SD+ D +SD SD
Sbjct: 952 NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
+S + ++ + +S D + S+S+ SDS D ++ +SDS SD+
Sbjct: 1012 SSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS--SDSSNSSDSSDSSDSSDS 1069
Query: 303 EVPKDNSGTMDLFGGAD--DISSGSDGED 329
D+S + D +D D S+ SD D
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098
Score = 123 bits (308), Expect = 6e-28
Identities = 85/334 (25%), Positives = 137/334 (41%), Gaps = 15/334 (4%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDS-DSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
+D SD+ + ++ DS SDS DS + +S S+ S SD DS S+
Sbjct: 969 SDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 61 LFGDDSEDEGASHHSGSDNHSERSD--NRSEASERSDHEDN-DPSDVDQHSGSEAPNDDE 117
D S+ +S S S + S+ SD N S++S+ SD D+ D SD S S +D
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDE-DKL 176
D + SD ++ S+ + S D + + + +SD + + SD D
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148
Query: 177 QNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDD-ERPVASDNDDEKQNSDDEEQP 235
++SD + ++D + SD S +SD + +SD+ D +SD +
Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1208
Query: 236 QLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
SD +S D + + S D + S+S+ SDS D + SD
Sbjct: 1209 DSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDS----SDSSDSTSD 1264
Query: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGED 329
S +SD++ N D S S+G D
Sbjct: 1265 SNDESDSQSKSGNGN-----NNGSDSDSDSEGSD 1293
Score = 120 bits (300), Expect = 5e-27
Identities = 88/327 (26%), Positives = 132/327 (40%), Gaps = 24/327 (7%)
Query: 10 SDADSEAERKDSDSGSDS-DSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
SD+ ++ DS + SDS DS + +S S+ S S+ + DS S+ + + S+
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDS-SNSSDS 826
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
+S S S N S+ SD +S+ SD D+D S+ S S +D D + SD
Sbjct: 827 SNSSDSSDSSNSSDSSD----SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS 882
Query: 129 HSEAEGSEKAHSDDEKWGRE----DKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEK 184
E S + S D + D S+ SD NS D + S D +SD
Sbjct: 883 SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS-SDNSNSSDSSNS 941
Query: 185 MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
++D + SD S +SD +SD+ + +SD + SD
Sbjct: 942 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001
Query: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
NS D + + +S D S S+ SDS D +SDS SD+
Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD-----------SSDSSDSSDSSD 1050
Query: 305 PKDNSGTMDLFGGAD--DISSGSDGED 329
D+S + D +D D S SD D
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSD 1077
Score = 119 bits (298), Expect = 9e-27
Identities = 87/354 (24%), Positives = 146/354 (41%), Gaps = 17/354 (4%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
+D + SD+DS SDS SDS + +S S+ S S+S + E S S
Sbjct: 583 SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS-- 640
Query: 62 FGDDSEDEGASHHSGSDNHSE--RSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE 119
DS D +S S + + S+ S N S++S+ SD D+ S +S + + D
Sbjct: 641 ---DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697
Query: 120 GHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGS--DEDKLQ 177
S S S+++ S+ + S + D S+ SD NS D + S D
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757
Query: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQL 237
+SD ++D + SD S + +SD +S++ D +SD +
Sbjct: 758 SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD--SSNSSDSSNSSDSSDSSDS 815
Query: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
SD + +SD S + SD + S+S+ GSDS+ ++ +SDS
Sbjct: 816 SDSDSSNSSDSSNSSDSSDSSNSSDSSD----SSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 298 ADSDTEVPKDNSGTMDLFGGAD--DISSGSDGEDKPPTPGQPVDENGLPQDQQE 349
S++ D+S + + +D D S+ SD + + ++ D E
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Score = 116 bits (290), Expect = 8e-26
Identities = 86/305 (28%), Positives = 130/305 (42%), Gaps = 34/305 (11%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
+ +DS SDS SDS + +S S+ S SD + DS S D S+
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS------DSSDSS 1082
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHED-NDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
+S S S N S+ SD+ S++S+ SD D +D SD S S +D D SD +
Sbjct: 1083 ESSDSSDSSNSSDSSDS-SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141
Query: 129 HSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNT 188
++ SE + S D D SD SD +S D + S D +SD + ++
Sbjct: 1142 SDSSDSSESSDSSDSS-DSSDSSDSSDSSDSSDSSDSSNSSDS-SDSSDSSDSSDSSDSS 1199
Query: 189 DDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD 248
D + SD S + +SD +SD+ D ++SD + SD +S D
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSNESSDSSDSSDSSDSSNSSDSSD 1254
Query: 249 ERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDN 308
+SD SD +E D +S+S G++ + S++DSD+E N
Sbjct: 1255 ----SSDSSDSTSDSNDESDSQSKSGNGNN---------------NGSDSDSDSEGSDSN 1295
Query: 309 SGTMD 313
T D
Sbjct: 1296 HSTSD 1300
Score = 115 bits (287), Expect = 2e-25
Identities = 81/338 (23%), Positives = 147/338 (43%), Gaps = 18/338 (5%)
Query: 9 GSDADSEAERK---DSDSGSDSDSDQENAASGSNASGSESDQDE--RGDSGQPSNKELFG 63
GSD++S+ D S D + + ++G++ + SESD + RGD+ S++
Sbjct: 442 GSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDN 501
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
+ D + SD+ S+ +++ S + + ++DND SD + + +D D + S
Sbjct: 502 GNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSS 561
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSD-EDKLQNSDDD 182
D S S+++ S+ S D D SD SD + +S+ + + SD D +SD
Sbjct: 562 D-SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSS 620
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDD-----ERPVASDNDDEKQNSDDEEQPQL 237
+ ++ E D + S+ ++S D + +S++ D +SD +
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680
Query: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHK----SESARGSDSEDEVLRMKRKNAIA 293
SD +S D ++ E S D + D S ++ SDS+ ++ +
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 294 SDSEADSDTEVPKDNSGTMDLFGGAD--DISSGSDGED 329
SDS SD+ D+S + D +D D S SD D
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778
Score = 110 bits (275), Expect = 4e-24
Identities = 79/319 (24%), Positives = 142/319 (44%), Gaps = 22/319 (6%)
Query: 21 SDSGSDSDSDQENAASGSNAS--GSESDQDERGDSGQPSNKELFGDDSEDEGASHHSG-S 77
S++GSDS+SD ++ + S G + + + + +N E + S AS++S S
Sbjct: 439 SNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDES 498
Query: 78 DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEK 137
++ SD++ + SD +D ++ D + NDD D+ G S S+++ S+
Sbjct: 499 KDNGNGSDSKGAEDDDSD-STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDS 557
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLS 197
++S D + S S+ +S D + + SD D +S+ + ++D + S
Sbjct: 558 SNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS 617
Query: 198 D--DERQQLSEEEKANSD-DERPVASDND--DEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
D D + S+ E +SD D + +SD++ D NSD + S+ +S D
Sbjct: 618 DSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDS 677
Query: 253 ASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTM 312
+S + +S D + S S+ SDS D +SDS++ ++ NS
Sbjct: 678 SSSSDSSNSSDSSDSSDSSNSSESSDSSD-----------SSDSDSSDSSDSSNSNSSDS 726
Query: 313 DLFGGAD--DISSGSDGED 329
D +D D S+ SD D
Sbjct: 727 DSSNSSDSSDSSNSSDSSD 745
Score = 108 bits (270), Expect = 2e-23
Identities = 72/280 (25%), Positives = 117/280 (41%), Gaps = 10/280 (3%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
+ +DS SDS SDS + +S S+ S + SD + DS S+ D S+
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDN-DPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
+S S S N S+ SD+ S++S+ SD D+ D SD S S +D D SD +
Sbjct: 1083 ESSDSSDSSNSSDSSDS-SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141
Query: 129 HSEAEGSEKAHSDDEKWGRE-----DKSDQSDDEKIQNSDDEERAQGSDE--DKLQNSDD 181
++ SE + S D + D SD SD NS D + S + D +SD
Sbjct: 1142 SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201
Query: 182 DEKMQNTDDEERPQLSDD-ERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 240
+ ++D + SD + S+ +N + +SD+ D +SD + SD
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSE 280
N + + S + + D + S+S + +
Sbjct: 1262 TSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 105 bits (262), Expect = 1e-22
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 11/329 (3%)
Query: 24 GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSER 83
G S+ N SN +GS+S+ D DS +K + GDD S+ G+D+ +
Sbjct: 425 GPGQKSEPGNKVGHSN-TGSDSNSDGY-DSYDFDDKSMQGDDPNSSDESN--GNDDANSE 480
Query: 84 SDNRSEASERSDHEDNDPSDVDQHSGSEAPN-DDEDEGHRSDGGSHHSEAEGSEKAHSDD 142
SDN S S R D N D +GS++ +D+D SD + S G+ +D
Sbjct: 481 SDNNS--SSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDND 538
Query: 143 EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKL-QNSDDDEKMQNTDDEERPQLSDDER 201
+ + KSD SD + +S+ + + SD D NS D ++D + +
Sbjct: 539 KSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS 598
Query: 202 QQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHS 261
S+ ++ + +SD+ D K +S E + K +SD +SD + S
Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD--NSDS 656
Query: 262 DDEEEQDHKSESARGSDSEDEVLRMKRKNAI-ASDSEADSDTEVPKDNSGTMDLFGGADD 320
D + S+S+ SDS D N+ +SDS S++ D+S + D
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716
Query: 321 ISSGSDGEDKPPTPGQPVDENGLPQDQQE 349
SS S+ D + ++ D +
Sbjct: 717 DSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745
Score = 100 bits (249), Expect = 4e-21
Identities = 76/364 (20%), Positives = 147/364 (40%), Gaps = 28/364 (7%)
Query: 4 MEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESD-QDERGDSGQ---PSNK 59
+E+ ++++ A K D G + + + G ++ ++++G G N
Sbjct: 355 VENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNV 414
Query: 60 ELFGDDSEDEGASHHSGSDN---HSER-SDNRSEASERSDHED-----NDPSDVDQHSGS 110
+ G+ EG S N HS SD+ S+ + D +D +DP+ D+ +G+
Sbjct: 415 KTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGN 474
Query: 111 EAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQ---------N 161
+ N + D S G + ++ E + + D K +D SD + D N
Sbjct: 475 DDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN 534
Query: 162 SDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASD 221
D+++ G + +SD + ++D + + S+ + ++SD SD
Sbjct: 535 DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594
Query: 222 NDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD----HKSESARGS 277
+ D +SD + SD +S D + +S E SD + + D + S+S+ S
Sbjct: 595 SSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNS 654
Query: 278 DSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQP 337
DS D ++ +SDS SD+ D+S + D +D +S + +
Sbjct: 655 DSSDS--SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 338 VDEN 341
D +
Sbjct: 713 SDSS 716
Score = 70.9 bits (172), Expect = 4e-12
Identities = 85/409 (20%), Positives = 153/409 (37%), Gaps = 67/409 (16%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQE--NAASGSNASGSESDQDERGDS------ 53
A +++ GS + + A+ +D D GS D D+E N SN S + QD +
Sbjct: 237 AGLDNSDGSPSGNGAD-EDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSI 295
Query: 54 GQPSNKELFGDDSEDEGASHHSGSDNHSERSDN-----------RSEASERSDHEDNDPS 102
GQ S+ + + D E + D S+ +N R E +++ +H ++
Sbjct: 296 GQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRV 355
Query: 103 D--VDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSD-------- 152
+ + + S + A +D+G G S + E ++ G+EDK
Sbjct: 356 ENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNE---GKEDKGQHGMILGKG 412
Query: 153 --QSDDEKI------QNSDDEERAQGSDEDKLQNSD-------DDEKMQNTDDEERPQLS 197
++ E + Q S+ + S+ NSD DD+ MQ D P S
Sbjct: 413 NVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDD----PNSS 468
Query: 198 DDE--RQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASD 255
D+ + E NS + ++D+ K N + + D++ SD ++
Sbjct: 469 DESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNG 528
Query: 256 EEHRHSDDEEEQD-----------HKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
+ +DD ++ D S+S+ SDS D + +SDS++
Sbjct: 529 NGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSS 588
Query: 305 PKDNSGTMDLFGGAD--DISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
+S + D +D D S SD D + D + D + +
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSD 637
Score = 64.3 bits (155), Expect = 3e-10
Identities = 78/382 (20%), Positives = 140/382 (36%), Gaps = 49/382 (12%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERG---DSGQPSNKELFGDDS 66
+ D+E E ++ ++ ++ + S +G++ + G D+G ++ +
Sbjct: 191 NSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNG 250
Query: 67 EDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGG 126
DE SG D E + + ++ E D D H S N D E + +G
Sbjct: 251 ADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGK 310
Query: 127 SH-HSEAEGSEKAHSDDEKWG-REDKSDQ--SDDEKIQN-----------SDDEERAQGS 171
H+E +G + + S++ G ED Q D +K+ + + E A G
Sbjct: 311 EDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGK 370
Query: 172 DEDK---LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKAN----------------S 212
+DK ++ + + + + +D+ Q K N S
Sbjct: 371 SQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKS 430
Query: 213 DDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSE 272
+ V N NSD + D++ MQ D P +SDE + + D E D+ S
Sbjct: 431 EPGNKVGHSNTGSDSNSDGYDSYDF-DDKSMQGDD---PNSSDESNGNDDANSESDNNSS 486
Query: 273 SA-----RGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
S +S+D K A DS++ SDT D++G + G DD G
Sbjct: 487 SRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTN-NSDSNGNGN--NGNDDNDKSDSG 543
Query: 328 EDKPPTPGQPVDENGLPQDQQE 349
+ K + ++ D +
Sbjct: 544 KGKSDSSDSDSSDSSNSSDSSD 565
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 12/227 (5%)
Query: 24 GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSER 83
G S D A + SN +G+ + GD G + E ED +GS+N +
Sbjct: 138 GQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQED--GPQVAGSNNST-- 193
Query: 84 SDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE---GHRSDGGSHHSEAEGSEKAHS 140
DN E E S + + S++ S+ E E G D G +S+ S
Sbjct: 194 -DNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGAD 252
Query: 141 DDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE--RPQLSD 198
+DE G D D+ +S++ + +G D K ++ D QN+D +E P+ +
Sbjct: 253 EDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGK-EDDHDSSIGQNSDSKEYYDPEGKE 311
Query: 199 DERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
D ++ + +K + +E D+ Q +D ++ + ++++N
Sbjct: 312 DPHNEV-DGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVEN 357
Score = 56.2 bits (134), Expect = 9e-08
Identities = 71/340 (20%), Positives = 130/340 (38%), Gaps = 62/340 (18%)
Query: 16 AERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHS 75
A + + G + D+ + G E + G GQ S ++ GA++ S
Sbjct: 100 ANEEGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSI-------IDNAGATNRS 152
Query: 76 GSDNHSERSDNRSEASERSDHEDND--PSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAE 133
++ +++++ + + +ED D Q +GS D+EDE + + + +E
Sbjct: 153 NTNGNTDKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSE 212
Query: 134 GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK-LQNSDDDEKMQNTDDEE 192
+ + +S K + + E G+ ED L NSD D++E
Sbjct: 213 ITPQINS-----------------KRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDE 255
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDER-- 250
DDE +EE N D S N+ + Q D + D QNSD +
Sbjct: 256 DEGSGDDE-----DEEAGNGKD-----SSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYY 305
Query: 251 -PQASDEEHRHSDDEEEQDHKSESA-----RGSDSEDEVLRMKRK------NAIASDSEA 298
P+ ++ H D ++ + SA GS ++ ++ + N I +SE
Sbjct: 306 DPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESET 365
Query: 299 -------DSDTEVPKDNSGTMDLFGGADDISSGSDG-EDK 330
D E+ +SG ++ ++ G++G EDK
Sbjct: 366 HAVGKSQDKGIEIKGPSSGNRNI---TKEVGKGNEGKEDK 402
Score = 38.5 bits (88), Expect = 0.020
Identities = 44/232 (18%), Positives = 82/232 (35%), Gaps = 10/232 (4%)
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
H D G + +G K + KW S + N + D K +
Sbjct: 62 HEGDRGRQENTQDG-HKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYG 120
Query: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 240
D +E ++ + Q+S + A + + + D QN D + D
Sbjct: 121 HD----GIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDV 176
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSE-DEVLRMKRKNAIASDSEAD 299
+Q ++ PQ + + +D+E+E S G+ SE + KR ++
Sbjct: 177 AVVQ---EDGPQVAGSNNS-TDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPG 232
Query: 300 SDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
+ + DNS GAD+ G+D+ G D + + Q+ ++
Sbjct: 233 TGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQD 284
Score = 30.4 bits (67), Expect = 5.5
Identities = 15/59 (25%), Positives = 24/59 (40%)
Query: 607 SSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDD 665
SSDS +GS+ D + R + S + + S + D +N+ SD D
Sbjct: 844 SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD 902
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 119 bits (297), Expect = 1e-26
Identities = 106/415 (25%), Positives = 177/415 (42%), Gaps = 72/415 (17%)
Query: 6 DLFGSDADSEAERKDSDSGSDSD-------SDQENAASGSNASGSESDQDERGDSGQPSN 58
+L SD++SE + DS S+S+ SD EN + S SES++ + N
Sbjct: 76 NLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSEN 135
Query: 59 KELFG---DDSEDEGASHHSGSDNHSER------SDNRSEASERSDHEDNDPSDVDQHSG 109
+EL DSE+E H SD+ E SD+ +E + + D++ + +H
Sbjct: 136 EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQA 195
Query: 110 SEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDE----KIQNSDDE 165
S++ N++ + SD S E + + S+ E+ R SD ++E +I +S+ E
Sbjct: 196 SDSENEEPPKPRMSD--SESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESE 253
Query: 166 E--RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPV---AS 220
+ R Q SD + + ++D R Q SD E ++L + ++S+ E P AS
Sbjct: 254 DPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPAS 313
Query: 221 DNDDEK--------QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSE 272
D++ E ++ DD ++ ++ +MQN D + HS D EE++HK +
Sbjct: 314 DSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQ 373
Query: 273 --------------------SARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTM 312
+A SDSEDE +K+ + SD++ DSD++ D SG
Sbjct: 374 KMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDAD-DSDSDAVSDKSGKR 432
Query: 313 DLFGGADDISS----------------GSDGEDKPPTPGQPVDENGLPQDQQEEE 351
+ +D GSD E D G D++EEE
Sbjct: 433 EKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEE 487
Score = 102 bits (255), Expect = 9e-22
Identities = 94/331 (28%), Positives = 157/331 (47%), Gaps = 52/331 (15%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASG----SESDQDERGDSGQPSNKELFGDDS 66
D + + + DSGSD + D SGS+ SE++ +R D G P + DS
Sbjct: 13 DGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED-GLPKGHHV--TDS 69
Query: 67 EDEGASHHSGSDNHSE----RSDNRSEASERSD--HEDNDPSDVDQHS------------ 108
E++ + + SD+ SE + D+ SE+ ER++ D++ DV+QH
Sbjct: 70 ENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLP 129
Query: 109 GSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERA 168
GS++ N++ GH SD SE E K + D + KS SD E ++D +
Sbjct: 130 GSDSENEELLNGHASD-----SENEDVGKHPASDSEIEELQKSPASDSE----TEDALKP 180
Query: 169 QGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQN 228
Q SD + + ++ +P++SD E ++L + + ++S+ E P D +
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSE-- 238
Query: 229 SDDEEQPQLSDEEKMQNSDDERPQASDEEH------RHSDDEEEQDHKSESARGSDSEDE 282
+++ +P++SD E + D R QASD E+ R SD E E ++++ SDSE+E
Sbjct: 239 NEELPKPRISDSE---SEDPPRHQASDSENEELPKPRISDSESEDPPRNQA---SDSENE 292
Query: 283 VLRMKRKNAIASDSEADSDTEVPKDNSGTMD 313
L R SDSE++ + P +S T D
Sbjct: 293 ELPKPR----VSDSESEGPQKGPASDSETED 319
Score = 83.6 bits (205), Expect = 5e-16
Identities = 78/326 (23%), Positives = 139/326 (42%), Gaps = 49/326 (15%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSN--------ASGSESDQDERGDSGQPSNKEL 61
SD++SE K S S+S+ + AS S S SES+ R + N+EL
Sbjct: 209 SDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEEL 268
Query: 62 FG---DDSEDEGASHHSGSDNHSER------SDNRSEASERSDHEDNDPSDVDQHSGSEA 112
DSE E + SD+ +E SD+ SE ++ D++ D +H
Sbjct: 269 PKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPE 328
Query: 113 PNDDEDEGHRSD-----GGSHHSEA----------EGSEKAHS-------DDEKWGREDK 150
+DD D ++ + S HS++ + E+ H +DEK G E+K
Sbjct: 329 SDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEK 388
Query: 151 SDQSDDEKIQNSDDEERAQGSDEDKLQNSDD---DEKMQNTDDEERPQLSDDERQQLSEE 207
+ + +S+DEE+A + ++DD D + E+ SD E + E
Sbjct: 389 VAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKEL 448
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
++++ SD++ S +EE+ ++D S DE + ++ +EE+
Sbjct: 449 SDKKNEEKDLFGSDSE-----SGNEEENLIAD--IFGESGDEEEEEFTGFNQEDLEEEKG 501
Query: 268 DHKSESARGSDSEDEVLRMKRKNAIA 293
+ + + A SDS+D + R K + ++
Sbjct: 502 ETQVKEAEDSDSDDNIKRGKHMDFLS 527
Score = 60.8 bits (146), Expect = 4e-09
Identities = 126/544 (23%), Positives = 211/544 (38%), Gaps = 96/544 (17%)
Query: 152 DQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKAN 211
DQSDD DE R GSD + D +E+ +D + S++E S+ E
Sbjct: 9 DQSDDGGATPVQDE-RDSGSDGE----DDVNEQHSGSDTGSVERHSENET---SDREDGL 60
Query: 212 SDDERPVASDNDDEKQ-NSDDEEQPQLSDEEKMQNSDDER--PQASDEEH----RHSDDE 264
S+ND+ N+ D E +L ++ + +ER P ASD E+ +H D
Sbjct: 61 PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
Query: 265 EEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSG 324
E ++ + GSDSE+E L N ASDSE + + P +S +L +S
Sbjct: 121 ESEE--TRKLPGSDSENEELL----NGHASDSENEDVGKHPASDSEIEEL---QKSPASD 171
Query: 325 SDGED--KPPTPGQPVDENGLPQ--DQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPN 380
S+ ED KP +E Q D + EEP P+ P+++ +L ++ +
Sbjct: 172 SETEDALKPQISDSESEEPPRHQASDSENEEP-PK-------PRMSDSESEELPKPQVSD 223
Query: 381 FLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARI 440
S EP P++ + E+EE+ + R+ D E E+ +
Sbjct: 224 SESEEP----PRHQASDSENEEL----PKPRISDSESEDPPRHQASDSENEELPKPRISD 275
Query: 441 VKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSAT 500
+ D + +E ++ K P D ++G + ++ +P S D +
Sbjct: 276 SESEDPPRNQASDSENEELPK-PRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS- 333
Query: 501 HRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQ 560
DR +K G D E Q + + R + +KQ
Sbjct: 334 ---------DRENK----------GEDTEMQN-DSFHSDSHMDRKKFHSSDSEEEEHKKQ 373
Query: 561 HQRGLSASYLEPDRYDEEEEGEE-------SISLAAIKNRYKGGIREERARIYSSDSDEG 613
D ++E+EGEE + L+ ++ K ++ R + DSD
Sbjct: 374 KM----------DSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD 423
Query: 614 SEEDKAQRLLKAKKLTSDEEG--EPSGKRKAEDD----DKANKKHKKYVIS-------DE 660
+ DK+ + K S+EE E S K+ E D D + ++ +I+ DE
Sbjct: 424 AVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDE 483
Query: 661 EEED 664
EEE+
Sbjct: 484 EEEE 487
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 97.4 bits (241), Expect = 4e-20
Identities = 96/370 (25%), Positives = 164/370 (44%), Gaps = 43/370 (11%)
Query: 6 DLFGSDADSEAERKDSDSGS--DSDSDQE-NAASGSNASGSESDQDERGDSG---QPSNK 59
D GS A ++ + S DSDSD+E + A E + D+ +P+ +
Sbjct: 58 DTSGSSVARRAPKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQ 117
Query: 60 E----LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPND 115
E + DD++D+ + D++S+ S+ + S+ S+ D++ D SEAP+D
Sbjct: 118 EPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDD------SEAPDD 171
Query: 116 DEDEGHRSDGGSHHSEA--EGSEKAHSDDEKWGREDKSDQSD--DEKIQNSDDEERAQGS 171
+ D+ D S S+ + S+ + D+ +D SD SD D+K +SD + +
Sbjct: 172 NSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDD 231
Query: 172 DEDKLQNSDDDEKM-QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
+ +SDD E ++DD E P S D+ SE +SDD +DD + + D
Sbjct: 232 SDVPDDSSDDSEAPDDSSDDSEAPDDSSDD----SEAPDDSSDDSEAPDDSSDDSEASDD 287
Query: 231 DEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMK-RK 289
+ + SD+ +SDD +A D++ SDD + + KS+ + D + L +
Sbjct: 288 SSDDSEASDD----SSDDS--EAPDDK---SDDSDVPEDKSDDSDVPDDNSDDLEVPVPA 338
Query: 290 NAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQP-----VDENGLP 344
+ ++ + SD E + + + +DD GE+ P P V E LP
Sbjct: 339 EDLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLP 398
Query: 345 QDQQEEEPIP 354
EEEP P
Sbjct: 399 ---TEEEPAP 405
Score = 95.9 bits (237), Expect = 1e-19
Identities = 81/275 (29%), Positives = 124/275 (45%), Gaps = 36/275 (13%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
D +D G+D + + D D +SD ++ A N+ SE+ D DS P +
Sbjct: 127 DNDDDNGNDLEVPDDNSDDSEAPDDNSD-DSEAPDDNSDDSEAPDDNSDDSEAPDDN--- 182
Query: 63 GDDSE-DEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDV--DQHSGSEAPNDDEDE 119
DDS+ + S S DN + SD+ S+ S+ D + +D SDV D S+ P+D D+
Sbjct: 183 SDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPD-DKSDDSDVPDDSSDDSDVPDDSSDD 241
Query: 120 GHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNS 179
D S SEA S D+ +D SD D E +S D+ A D + S
Sbjct: 242 SEAPDDSSDDSEAPDD----SSDDSEAPDDSSD--DSEAPDDSSDDSEASDDSSDDSEAS 295
Query: 180 DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQP---- 235
DD ++DD E P +++ +SD + D+D NSDD E P
Sbjct: 296 DD-----SSDDSEAP-----------DDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 339
Query: 236 QLSDEEKMQNSDDERPQASD--EEHRHSDDEEEQD 268
L +E ++ + ++E +A+ +H SDD EQD
Sbjct: 340 DLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQD 374
Score = 92.8 bits (229), Expect = 9e-19
Identities = 82/301 (27%), Positives = 134/301 (44%), Gaps = 23/301 (7%)
Query: 3 DMEDLFGSDADSEAERKDSD-SGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNK-- 59
D+E + DSEA +SD S + D+ ++ A N+ SE+ D DS P +
Sbjct: 135 DLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSD 194
Query: 60 ---ELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDV----DQHSGSEA 112
+ DDS D+ + D+ S+ SD ++S+ SD D+ D D SEA
Sbjct: 195 DSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEA 254
Query: 113 PNDDEDEGHRSDGGSHHSEA--EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQG 170
P+D D+ D S SEA + S+ + + D+ D S+ SDD + ++++
Sbjct: 255 PDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDS---SDDSEASDDSSDDSEAPDDKSDD 311
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPV-ASDNDDEKQNS 229
SD + ++ D D N+DD E P ++D L E + SD+E V A+ + +S
Sbjct: 312 SDVPEDKSDDSDVPDDNSDDLEVPVPAED----LCNEGQIASDEEELVEAAAAVSQHDSS 367
Query: 230 DDEEQPQLSDEEKMQNSDDE-RPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKR 288
DD + L + SD E P+ S E + +EE +S + ++ R
Sbjct: 368 DDAGEQDLGENLSKPPSDPEANPEVS--ERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPR 425
Query: 289 K 289
K
Sbjct: 426 K 426
Score = 91.3 bits (225), Expect = 3e-18
Identities = 92/358 (25%), Positives = 139/358 (38%), Gaps = 73/358 (20%)
Query: 21 SDSGSDSDSDQENAASGSNASGS---ESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
S SG S S A AS +SD DE + + +L +S+DE
Sbjct: 54 SRSGDTSGSSVARRAPKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESP------ 107
Query: 78 DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEK 137
E + E +D +D D + E P+D+ D+ D S SEA
Sbjct: 108 ----ECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAP---- 159
Query: 138 AHSDDEKWGREDKSDQSDDEKI--QNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQ 195
DD E D SDD + NSDD + + +D ++ DD N+DD + P
Sbjct: 160 ---DDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVP- 215
Query: 196 LSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASD 255
D++ S+ +SDD SD D+ +SDD E P S + D E P S
Sbjct: 216 ---DDKSDDSDVPDDSSDD-----SDVPDD--SSDDSEAPDDSSD------DSEAPDDS- 258
Query: 256 EEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLF 315
SDD E D S+ + D + DSEA D+
Sbjct: 259 -----SDDSEAPDDSSDDSEAPDDSSD------------DSEASDDS------------- 288
Query: 316 GGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRI-EVEIPKVNTDLGND 372
+DD + D D P D++ +P+D+ ++ +P+ ++E+P DL N+
Sbjct: 289 --SDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNE 344
Score = 80.5 bits (197), Expect = 5e-15
Identities = 71/272 (26%), Positives = 113/272 (41%), Gaps = 33/272 (12%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
+D D +S+ D+ DSD +N+ S+ + +S D DS P +K D
Sbjct: 164 DDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSD 223
Query: 65 ---DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSG-SEAPNDDEDEG 120
DS D+ SD+ SE D+ S+ SE D +D D S SEAP+D D+
Sbjct: 224 VPDDSSDDSDVPDDSSDD-SEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDS 282
Query: 121 HRSDGGSHHSEA--EGSEKAHSDDEKWGR----EDKSDQSD------------------- 155
SD S SEA + S+ + + D+K EDKSD SD
Sbjct: 283 EASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLC 342
Query: 156 -DEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDE-ERPQLSDDERQQLSEEEKANSD 213
+ +I SD+EE + + +S DD Q+ + +P + ++SE + +
Sbjct: 343 NEGQIA-SDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEE 401
Query: 214 DERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
+ PV + K + +P + K +N
Sbjct: 402 EPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKN 433
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 89.7 bits (221), Expect = 8e-18
Identities = 65/352 (18%), Positives = 145/352 (41%), Gaps = 14/352 (3%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G + E E ++ D + + + E G G E + + + G+ +E G E+
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGE---GEEVEGEREKEEGERKKEERAG--KEE 785
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
+G + E ++ R E E+ + + + +V++ G ++E EG +G
Sbjct: 786 KGEEEGDQGEGEEEETEGRGE--EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
Query: 129 HSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNT 188
E EG E+ + E+ + + E+ + +EE +G E++ + ++E+ +
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903
Query: 189 DDEERPQLSDDERQQLSEEEKA----NSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
+EE ++E + EE+ +E + +D + ++EE +EE+ +
Sbjct: 904 GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963
Query: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
+E + EE +EEE + + E G + +E + + + E + + EV
Sbjct: 964 GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG--EGEGEEEEEGEV 1021
Query: 305 PKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPET 356
+ G + G ++ +GE++ + ++++EE ET
Sbjct: 1022 EGEVEGE-EGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQET 1072
Score = 89.7 bits (221), Expect = 8e-18
Identities = 63/350 (18%), Positives = 138/350 (39%), Gaps = 21/350 (6%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
+ E E D + + + + + G G ++ + + KE G++ D+G
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG 796
Query: 73 HHSGSDNHSERSDNRSEA---------SERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
++ E + E ER + E+ + ++ G E + E+E
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDE 183
G E EG E+ + E G E++ + +E+ + +EE +G E++ + ++E
Sbjct: 857 KGEEEGEEGEGEEEG-EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
Query: 184 KMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKM 243
+ + +EE +E + EEE+ + E ++E + +EE+ + EE+
Sbjct: 916 EGEGKGEEE-----GEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
Query: 244 QNSDDERPQASDEEHRHSDDEEE--QDHKSESARGSDSEDEVLRMKRKNAIASDSEADSD 301
+ +E +EE + EEE ++ E G + + + + + + E +
Sbjct: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG 1030
Query: 302 TEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
++ G + ++ +GE+ + +E G Q+ EEE
Sbjct: 1031 EGEGEEEEGEEE----GEEREKEGEGEENRRNREEEEEEEGKYQETGEEE 1076
Score = 89.0 bits (219), Expect = 1e-17
Identities = 72/368 (19%), Positives = 150/368 (40%), Gaps = 32/368 (8%)
Query: 1 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
+A+ E+ D + E E+K+ + G + +QE G G ++E GD + KE
Sbjct: 696 LAEKEEWKKRDGE-EQEQKEREQGHQKERNQEMEEGGEEEHGE--GEEEEGDREEEEEKE 752
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
+ ++EG + E + + E ER+ E+ + DQ G E + E
Sbjct: 753 ---GEGKEEGEGEEVEGEREKEEGERKKE--ERAGKEEKGEEEGDQGEGEEEETEGRGEE 807
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
G E E + ++E+ G E + ++ + E+ + +EE +G E++ + +
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEG-EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Query: 181 DDEKMQNTD----DEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQ 236
+E+ + + +EE ++E + EEE+ + E + ++E+ EE+ +
Sbjct: 867 GEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 237 LSDEE-------------KMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV 283
+ E + + ++E +EE + EEE + + E G E+E
Sbjct: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
Query: 284 LRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGL 343
+ + E + + E + G + G + G +GE G+ +E G
Sbjct: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE------GEGEEEEGE 1040
Query: 344 PQDQQEEE 351
+ ++ E+
Sbjct: 1041 EEGEEREK 1048
Score = 84.3 bits (207), Expect = 3e-16
Identities = 74/399 (18%), Positives = 154/399 (38%), Gaps = 26/399 (6%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
E++ G E ERK + + +E G G E + + RG+ + + G+
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEE---GDQGEGEEEETEGRGEEKEEGGEVEGGE 818
Query: 65 DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPS----DVDQHSGSEAPNDDEDEG 120
E +G + E + E E E+ + ++ G E + E EG
Sbjct: 819 VEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG 878
Query: 121 HRSDG---GSHHSEAEGSE-----KAHSDDEKWGREDKSD---QSDDEKIQNSDDEERAQ 169
+G G E EG E + + E G E++ + + + E+ + +EE +
Sbjct: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938
Query: 170 GSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNS 229
G ED +++E ++EE ++E + EE + ++E + ++E+
Sbjct: 939 GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG-EGEGEEEEGEE 997
Query: 230 DDEEQPQLSDEEKMQNSDDERPQASDE---EHRHSDDEEEQDHKSESARGSDSEDEVLRM 286
+ EE+ + +E + + ++E + E E + EEE+ + R + E E R
Sbjct: 998 EGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRR 1057
Query: 287 KRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQD 346
R+ + + E + + + S G+ K + G ++
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKE 1117
Query: 347 QQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVE 385
Q+ + P+ R+ P + N++ LP++L ++
Sbjct: 1118 QRSKMPVQSKRLLKNGPSGSKKFWNNV----LPHYLELK 1152
Score = 78.2 bits (191), Expect = 2e-14
Identities = 75/365 (20%), Positives = 144/365 (39%), Gaps = 26/365 (7%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
+DL SE + K D + + +SG+E QDE + G+ +K
Sbjct: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGE-KDKGRGEM 686
Query: 65 DSEDEGASHHSGSDNHSERSDNRSEASERSD-HEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
+ EG + + +R E ER H+ ++++ E +E+EG R
Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746
Query: 124 DG----GSHHSEAEGSE------KAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDE 173
+ G E EG E K + +K R K ++ ++E Q +EE +G E
Sbjct: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGE 806
Query: 174 DKLQNSDDD----EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNS 229
+K + + + E+ + +EE + +E + EEE+ ++E ++ ++
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Query: 230 DDEE----QPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR 285
+EE + + +EE ++E +EE + EEE + + E G +E
Sbjct: 867 GEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE--E 924
Query: 286 MKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQ 345
+ + E + + E D G + G + +GE + G+ E G +
Sbjct: 925 GEEGEGEGEEEEGEGEGE---DGEGEGEEEEGEWE-GEEEEGEGEGEEEGEGEGEEGEGE 980
Query: 346 DQQEE 350
++EE
Sbjct: 981 GEEEE 985
Score = 72.8 bits (177), Expect = 1e-12
Identities = 67/338 (19%), Positives = 136/338 (40%), Gaps = 30/338 (8%)
Query: 30 DQENAASGSNASGSESDQDERGDS------GQPSNKELFGDDSEDEGASHHSGSDNHSER 83
+++ A S +G E + E + G+ E+ DD D+ + + E
Sbjct: 588 EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA 647
Query: 84 SDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGS-EKAHSDD 142
D + + E + SG+E D+E E D G E G EK ++
Sbjct: 648 EDGPEGRGDGTCEEGS--------SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699
Query: 143 EKWGREDKSDQSDDEKIQNSDDE---ERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDD 199
E+W + D +Q E+ Q E E +G +E+ + +++ + +++E +
Sbjct: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759
Query: 200 ERQQLS----EEEKANSDDERPVASDNDDEK--QNSDDEEQPQLSDEEKMQNSDDERPQA 253
E +++ +EE +ER + +E+ Q +EE+ + EEK + + E +
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 254 SDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMD 313
EE + +EEE++ + E G E+E + + + E + + G
Sbjct: 820 --EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE-- 875
Query: 314 LFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
G ++ +GE++ G+ + G +++ E E
Sbjct: 876 --GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911
Score = 61.6 bits (148), Expect = 2e-09
Identities = 71/313 (22%), Positives = 129/313 (41%), Gaps = 26/313 (8%)
Query: 59 KELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDED 118
++ G+ ++D + + SD + E S+ + E H + EA +D+E
Sbjct: 526 QQTIGELTQDTALTENDDSDEYEEMSEMK-EGKACKQHVSQGIFMTQPATTIEAFSDEEV 584
Query: 119 EGHRSDGGSHHSEAEGSEK----AHSDDEK--WGREDKSD-QSDD--EKIQNSDDEERAQ 169
E G+ S+ G E+ A+ ++ K GR++K++ SDD +K + S+ + ++
Sbjct: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSV 644
Query: 170 GSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND----DE 225
G ED + D + + E Q DE ++ E++K + ERP + + +E
Sbjct: 645 GEAEDGPEGRGDGTCEEGSSGAEHWQ---DEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
Query: 226 KQNSDDEEQPQLSDEEKMQNS-DDERPQASDEEHRHS------DDEEEQDHKSESARGSD 278
+ D EEQ Q E+ Q + E + +EEH +EEE+ G
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
Query: 279 SEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPV 338
E E R K + + A E + G + G + E+ G V
Sbjct: 762 EEVEGEREKEEGERKKEERAGK--EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 339 DENGLPQDQQEEE 351
+E ++++EEE
Sbjct: 820 EEGKGEREEEEEE 832
Score = 35.4 bits (80), Expect = 0.17
Identities = 33/133 (24%), Positives = 59/133 (44%), Gaps = 8/133 (6%)
Query: 534 EMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNR 593
E+ +KEE + R E Q+++ RE+ HQ+ + +E +E EGEE +
Sbjct: 695 ELAEKEEWKKRDG---EEQEQKEREQGHQKERNQE-MEEGGEEEHGEGEEEEGDREEEEE 750
Query: 594 YKGGIRE--ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKK 651
+G +E E + E E K +R K +K +EEG+ + E + + +K
Sbjct: 751 KEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEK--GEEEGDQGEGEEEETEGRGEEK 808
Query: 652 HKKYVISDEEEED 664
+ + E E+
Sbjct: 809 EEGGEVEGGEVEE 821
Score = 34.7 bits (78), Expect = 0.29
Identities = 85/451 (18%), Positives = 163/451 (36%), Gaps = 42/451 (9%)
Query: 229 SDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR--M 286
+ +E+ +LS +K + D +DD +E + SE G + V +
Sbjct: 509 NSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIF 568
Query: 287 KRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQD 346
+ A ++ +D + E+P++ G D G + E+ G ++ + D
Sbjct: 569 MTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD 628
Query: 347 QQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDE 406
+ + EV K + +G + + E ++++DE ++ D+
Sbjct: 629 DLTD------KAEVSEGKAKS-VGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDK 681
Query: 407 ---------EGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVF 457
EG L K E W+ +RD E E KE K + + + G E
Sbjct: 682 GRGEMERPGEGEKELAEKEE----WK-KRDGEEQEQKEREQGHQK--ERNQEMEEGGEEE 734
Query: 458 DVYKAPLQGDHNHLFIRQGTGLQ---GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSK 514
+GD ++G G + G+ V + + +K +R K
Sbjct: 735 HGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER------EKEEGERKK-----EERAGK 783
Query: 515 TQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDR 574
+K G E + +++EE + + RE++ + G E +
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG-EGEEEEGEG 842
Query: 575 YDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEG 634
+EE EGEE + + G EE + +E EE + + + + +EEG
Sbjct: 843 EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE--EEGEGEGEEEGEGEGEEEEG 900
Query: 635 EPSGKRKAEDDDKANKKHKKYVISDEEEEDD 665
E G+ + E + + + K EE E +
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE 931
Score = 31.6 bits (70), Expect = 2.5
Identities = 31/138 (22%), Positives = 58/138 (42%), Gaps = 11/138 (7%)
Query: 529 ECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLA 588
E + E +++EE R R ++ + E+ Q G R +E+EEG E
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ-GEGEEEETEGRGEEKEEGGE----- 813
Query: 589 AIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKA 648
+GG EE + +EG E++ + + +EEGE G+ + E+ +
Sbjct: 814 -----VEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868
Query: 649 NKKHKKYVISDEEEEDDD 666
+ + +EEE + +
Sbjct: 869 EEGEEGEGEGEEEEGEGE 886
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 89.4 bits (220), Expect = 1e-17
Identities = 99/456 (21%), Positives = 187/456 (41%), Gaps = 41/456 (8%)
Query: 9 GSDAD-SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
G D D +++ + +++ + + + G A +E D E QP ++++ + E
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV--EAPE 1878
Query: 68 DEGASHHSGSDNHSERSD----NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
EG + D + ++ SE +E + E + + E +DE E +
Sbjct: 1879 AEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGA 1938
Query: 124 DGGSHH---SEAEGSEKAHSD--DEKWGREDKSDQSDD-----EKIQNSDDEERAQGSDE 173
+ EAEG + S+ + + E+ +S+D +++ + E AQ E
Sbjct: 1939 EAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE 1998
Query: 174 DKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEE 233
D ++ + + +MQ ++E +P+ E Q SE E+A + E D + SD E
Sbjct: 1999 D-VEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEA-QEVEGETQKTEGDAQPESDGVE 2056
Query: 234 QPQLSDEEKMQNSDDERPQASDEEHRHSDD------EEEQDHKSESARGSDSEDEVLRMK 287
P+ EE+ Q ++ E +A E H S+D E E +SE ++E E + +
Sbjct: 2057 APEA--EEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 288 RKNAIASDSEADSDT---EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPG---QPVDEN 341
A ++ EA ++ E P+ G + + ++GE +P + G Q +E
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVE--AQDAEGEAQPESEGIEAQEAEEE 2172
Query: 342 GLPQDQQEEEPIPETRIE-----VEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYED 396
P+ + E P E + +E P+ + +L V+ P E +P
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPE-AEEEAQPEPEGVETP 2231
Query: 397 EFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNE 432
E E E + EG T+ + K + + EE +E
Sbjct: 2232 EAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASE 2267
Score = 74.7 bits (182), Expect = 3e-13
Identities = 79/397 (19%), Positives = 158/397 (39%), Gaps = 42/397 (10%)
Query: 20 DSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDN 79
++ +G D D Q + A G A +E + + + E GD E EG + D
Sbjct: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAE--GDAQEAEGEAQPESEDV 1874
Query: 80 HSERSDNRSEASERSDHEDNDPSDVDQHS-GSEAPNDDEDEGHRSDG-------GSHHSE 131
+ ++ ++ +V S G+EAP +++ ++ G E
Sbjct: 1875 EAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPE 1934
Query: 132 AEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDE 191
+EG+E +++ E ++ Q + E I++ + EE AQ ED ++ + + + Q + E
Sbjct: 1935 SEGAEAQEAEEAAQEAEGQT-QPESEVIESQEAEEEAQPESED-VEALEVEVETQEAEGE 1992
Query: 192 ERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERP 251
+P+ D E A + + E Q +++E QP+ E S+ E
Sbjct: 1993 AQPESEDVE------------------APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEA 2034
Query: 252 QASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
Q + E + ++ + + + S+ ++E+E + A EA+ + ++
Sbjct: 2035 QEVEGETQKTEGDAQPE--SDGVEAPEAEEEA-----QEAEGEVQEAEGEAHPESEDVDA 2087
Query: 312 MDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGN 371
+ G A S+G + P G+ G+ + E E PE+ +E P+ +
Sbjct: 2088 QEAEGEAQP---ESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGEAQP 2143
Query: 372 DLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEG 408
+ V+ + E +P E E+E + EG
Sbjct: 2144 ESEGVEAQD-AEGEAQPESEGIEAQEAEEEAQPELEG 2179
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/312 (20%), Positives = 115/312 (36%), Gaps = 31/312 (9%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
+ ED+ +A+ EA+ + S+ E A G E+ + E QP ++ +
Sbjct: 2081 ESEDVDAQEAEGEAQPE-----SEGVEAPEAEGEAQKAEGIEAPETE--GEAQPESEGIE 2133
Query: 63 GDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHR 122
++E E G + + + E SE + ++ + + G EAP + E E
Sbjct: 2134 APEAEGEAQPESEGVEAQDAEGEAQPE-SEGIEAQEAEEEAQPELEGVEAP-EAEGEAQP 2191
Query: 123 SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
G EAEG + + + ++ Q + E ++ + E AQ E + Q
Sbjct: 2192 ESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQG---- 2247
Query: 183 EKMQNTDDEERPQLS--DDERQQLSEEEKANSDDE--RPVASDNDDEKQNSDDEEQPQLS 238
+ + PQ+S D + ++ SE +D P + D Q + P S
Sbjct: 2248 ------EKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSS 2301
Query: 239 DEEKMQNSDDERPQASDEEHRH-SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
N D E+ H D D KS +E + RM +++ + E
Sbjct: 2302 RASSWGNC-----WQKDSENDHVLGDTRSPDAKSTGT--PHAERKATRMYPESSTSEQEE 2354
Query: 298 ADSDTEVPKDNS 309
A + P+ +
Sbjct: 2355 APLGSRTPEQGA 2366
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/172 (20%), Positives = 70/172 (40%), Gaps = 14/172 (8%)
Query: 197 SDDERQQLSEEEKANSDDERPVASDNDDEKQNSD----------DEEQPQLSD---EEKM 243
++DE ++ SEE++A+S+ E+ + +E Q + EE QL + EE +
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKR-KNAIASDSEADSDT 302
Q + + + E +EE Q + E G ++E ++++ K + ++
Sbjct: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
Query: 303 EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIP 354
E K+ + ++S S + K PV E + EP P
Sbjct: 1392 EGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCP 1443
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 85.1 bits (209), Expect = 2e-16
Identities = 86/373 (23%), Positives = 148/373 (39%), Gaps = 48/373 (12%)
Query: 14 SEAERKDSDSGSDSDSDQENAASG---SNASGSESDQDERGDSGQPSNKELFGDD----- 65
S++ + + GSD A G S G + D+ DSG + FGDD
Sbjct: 67 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD----DTFGDDDSGPG 122
Query: 66 --SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
EG + GSD E SD+ +ASE S + D + E N+D + +
Sbjct: 123 PKDRQEGGNSRLGSD---EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS-KP 178
Query: 124 DGGSHHSEAE--------GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK 175
+GG E+E GS+ S + +D+ QSDD + S+ S K
Sbjct: 179 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 238
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND---------DEK 226
+ S ++ + NT D QL + +++ + + + +D+R DN+ E
Sbjct: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 298
Query: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRH----SDDEEEQDHKSESARGSDSEDE 282
NS D Q + K + +D + S EE ++ S + ++ + S S+S++E
Sbjct: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358
Query: 283 VLRMKR---KNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED------KPPT 333
V+ R + S E D++ +++S ++ +D E +
Sbjct: 359 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 418
Query: 334 PGQPVDENGLPQD 346
P P DEN Q+
Sbjct: 419 PESPEDENSSSQE 431
Score = 84.7 bits (208), Expect = 2e-16
Identities = 87/401 (21%), Positives = 157/401 (39%), Gaps = 54/401 (13%)
Query: 5 EDLFGSDADSEAERKD------SDSGSDSDSDQENAASGSNA-SGSESDQDERGDSGQPS 57
+D FG D DS KD S GSD DSD AS +A G +S QD +S +
Sbjct: 111 DDTFGDD-DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 169
Query: 58 NKELFGDDSEDEGASHHSGSDNH-----SERSDNRSEASERSDH--EDNDPSDVDQHSGS 110
N++ E ++ S S+ H S+ + + SE D + +DP + G+
Sbjct: 170 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 229
Query: 111 -----------EAPNDDEDEGHRSDGGSHHSE------------AEGSEKAHSDDEKWGR 147
E+ + E + GGS E +E +++ DD
Sbjct: 230 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME 289
Query: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
E KSD +++ +++ + + S D ++S ++ + + + + P + LS +
Sbjct: 290 EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ 349
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
E ++ E V+ ++ D P S E ++SD +S+E+ H+ +
Sbjct: 350 ENSSESQEEVVS-------ESRGDNPDPTTSYVEDQEDSD-----SSEEDSSHTLSHSKS 397
Query: 268 DHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
+ + E A SE L ++ + + E S E + +S + + +++ S D
Sbjct: 398 ESREEQADSESSES--LNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 453
Query: 328 EDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTD 368
D + D N EE IE+E K+ D
Sbjct: 454 SDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
Score = 66.6 bits (161), Expect = 7e-11
Identities = 52/198 (26%), Positives = 95/198 (47%), Gaps = 29/198 (14%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESD--QDERGDSGQPSN---KELFGDDSED 68
S+ E ++ D S S + N +S N+S S+ + + RGD+ P+ ++ DS +
Sbjct: 326 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 385
Query: 69 EGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
E +SH HS S++ E++D SE+SE + + E+P EDE S
Sbjct: 386 EDSSHTLSHSKSESREEQAD--SESSESLNFSE------------ESPESPEDENSSSQE 431
Query: 126 G--SHHSEAEG-SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
G SH S AE SE++HS+++ +D S +D ++ E ++ ++ +L+N + +
Sbjct: 432 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKED----SNSTESKSSSEEDGQLKNIEIE 487
Query: 183 EKMQNTDDEERPQLSDDE 200
+ D + D +
Sbjct: 488 SRKLTVDAYHNKPIGDQD 505
Score = 62.0 bits (149), Expect = 2e-09
Identities = 72/311 (23%), Positives = 120/311 (38%), Gaps = 65/311 (20%)
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHE--DNDPSDVDQHSGSEAPNDDEDEGH 121
+DSE E H + + S SE S+ S E + DPSD Q S +DD +
Sbjct: 28 EDSE-EWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ-SEEGLGSDDHQYIY 85
Query: 122 RSDGGSHHSEAEGSEKAHSD-----DEKWGREDK----------------SDQSDDEKIQ 160
R GG S +G + D D+ +G +D SD+ D+ IQ
Sbjct: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
Query: 161 NSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE------------- 207
S+ E QG D + S+ E + +P+ D ++ SEE
Sbjct: 146 ASE-ESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 204
Query: 208 --------EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD----------- 248
E SDD + S+ + + NS + + + + N+ D
Sbjct: 205 GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPS 264
Query: 249 ----ERPQASDEEHRH--SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
+ + S+E+ R D+ ++ KS+S S+S D L R+++ DS+ DS
Sbjct: 265 RKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS-KGDSQEDSKE 323
Query: 303 EVPKDNSGTMD 313
+ ++ S +D
Sbjct: 324 NLSQEESQNVD 334
Score = 45.8 bits (107), Expect = 1e-04
Identities = 108/552 (19%), Positives = 204/552 (36%), Gaps = 126/552 (22%)
Query: 104 VDQHSGSEAPNDDEDEGHRSDGGSHHSEA-EGSEKAHSDDEKWGREDKSDQSDDEKIQNS 162
V ++ +E+ + +E +GH + + E+ E SE + E+ ED SD + E+ S
Sbjct: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78
Query: 163 DDEE---RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVA 219
DD + R G DD+ DD+E DD S ++ DD P
Sbjct: 79 DDHQYIYRLAGGFSRSTGKGGDDK-----DDDE-----DD-----SGDDTFGDDDSGPGP 123
Query: 220 SDNDD---EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARG 276
D + + SD++ ++ +Q S++ PQ D QD SES R
Sbjct: 124 KDRQEGGNSRLGSDEDS------DDTIQASEESAPQGQDSA---------QDTTSES-RE 167
Query: 277 SDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQ 336
D+ED V DS+ + + S + GG+D SS D G
Sbjct: 168 LDNEDRV-----------DSKPEGGDSTQESESEEHWVGGGSDGESSHGD--------GS 208
Query: 337 PVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYED 396
+D+ G+ Q ++P + ++ GN + S E Q
Sbjct: 209 ELDDEGM----QSDDP----------ESIRSERGNSR--MNSAGMKSKESGENSEQANTQ 252
Query: 397 EFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEV 456
+ ++L+ R + + RI +++ +E+ ++N SD + + + +
Sbjct: 253 DSGGSQLLEHPSRKIFR-------KSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTG 305
Query: 457 FDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQ 516
+ +GD + + Q V S + ++ LS + S++Q
Sbjct: 306 LSQPRRDSKGDSQEDSKENLSQEESQNV---------DGPSSESSQEANLSSQENSSESQ 356
Query: 517 KIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYD 576
+ + G +P+ T ++ +E+ + E+ LS S E
Sbjct: 357 EEVVSESRGDNPD-PTTSYVEDQEDSDSS------------EEDSSHTLSHSKSESREEQ 403
Query: 577 EEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKA--QRLLKAKKLTSDEEG 634
+ E ES++ +S +S E E++ + Q L++ +++ +
Sbjct: 404 ADSESSESLN-------------------FSEESPESPEDENSSSQEGLQSHSSSAESQS 444
Query: 635 EPSGKRKAEDDD 646
E S +E+DD
Sbjct: 445 EES---HSEEDD 453
Score = 38.1 bits (87), Expect = 0.026
Identities = 35/138 (25%), Positives = 53/138 (38%), Gaps = 17/138 (12%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
D ED S+ DS S S S+S +Q ++ S + + SE + D S + L
Sbjct: 377 DQEDSDSSEEDSSHTL--SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
Query: 63 GDDSEDEGASHHSGS--------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---- 110
S E S S S D+ + D+ S S+ S ED +++ S
Sbjct: 435 SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
Query: 111 ---EAPNDDEDEGHRSDG 125
P D+D+ DG
Sbjct: 495 AYHNKPIGDQDDNDCQDG 512
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 85.1 bits (209), Expect = 2e-16
Identities = 86/373 (23%), Positives = 148/373 (39%), Gaps = 48/373 (12%)
Query: 14 SEAERKDSDSGSDSDSDQENAASG---SNASGSESDQDERGDSGQPSNKELFGDD----- 65
S++ + + GSD A G S G + D+ DSG + FGDD
Sbjct: 51 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD----DTFGDDDSGPG 106
Query: 66 --SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
EG + GSD E SD+ +ASE S + D + E N+D + +
Sbjct: 107 PKDRQEGGNSRLGSD---EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS-KP 162
Query: 124 DGGSHHSEAE--------GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK 175
+GG E+E GS+ S + +D+ QSDD + S+ S K
Sbjct: 163 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 222
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND---------DEK 226
+ S ++ + NT D QL + +++ + + + +D+R DN+ E
Sbjct: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 282
Query: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRH----SDDEEEQDHKSESARGSDSEDE 282
NS D Q + K + +D + S EE ++ S + ++ + S S+S++E
Sbjct: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 342
Query: 283 VLRMKR---KNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED------KPPT 333
V+ R + S E D++ +++S ++ +D E +
Sbjct: 343 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 402
Query: 334 PGQPVDENGLPQD 346
P P DEN Q+
Sbjct: 403 PESPEDENSSSQE 415
Score = 84.7 bits (208), Expect = 2e-16
Identities = 87/401 (21%), Positives = 157/401 (39%), Gaps = 54/401 (13%)
Query: 5 EDLFGSDADSEAERKD------SDSGSDSDSDQENAASGSNA-SGSESDQDERGDSGQPS 57
+D FG D DS KD S GSD DSD AS +A G +S QD +S +
Sbjct: 95 DDTFGDD-DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 153
Query: 58 NKELFGDDSEDEGASHHSGSDNH-----SERSDNRSEASERSDH--EDNDPSDVDQHSGS 110
N++ E ++ S S+ H S+ + + SE D + +DP + G+
Sbjct: 154 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 213
Query: 111 -----------EAPNDDEDEGHRSDGGSHHSE------------AEGSEKAHSDDEKWGR 147
E+ + E + GGS E +E +++ DD
Sbjct: 214 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME 273
Query: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
E KSD +++ +++ + + S D ++S ++ + + + + P + LS +
Sbjct: 274 EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ 333
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
E ++ E V+ ++ D P S E ++SD +S+E+ H+ +
Sbjct: 334 ENSSESQEEVVS-------ESRGDNPDPTTSYVEDQEDSD-----SSEEDSSHTLSHSKS 381
Query: 268 DHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
+ + E A SE L ++ + + E S E + +S + + +++ S D
Sbjct: 382 ESREEQADSESSES--LNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 437
Query: 328 EDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTD 368
D + D N EE IE+E K+ D
Sbjct: 438 SDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
Score = 66.6 bits (161), Expect = 7e-11
Identities = 52/198 (26%), Positives = 95/198 (47%), Gaps = 29/198 (14%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESD--QDERGDSGQPSN---KELFGDDSED 68
S+ E ++ D S S + N +S N+S S+ + + RGD+ P+ ++ DS +
Sbjct: 310 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 369
Query: 69 EGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
E +SH HS S++ E++D SE+SE + + E+P EDE S
Sbjct: 370 EDSSHTLSHSKSESREEQAD--SESSESLNFSE------------ESPESPEDENSSSQE 415
Query: 126 G--SHHSEAEG-SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
G SH S AE SE++HS+++ +D S +D ++ E ++ ++ +L+N + +
Sbjct: 416 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKED----SNSTESKSSSEEDGQLKNIEIE 471
Query: 183 EKMQNTDDEERPQLSDDE 200
+ D + D +
Sbjct: 472 SRKLTVDAYHNKPIGDQD 489
Score = 59.7 bits (143), Expect = 8e-09
Identities = 66/310 (21%), Positives = 116/310 (37%), Gaps = 57/310 (18%)
Query: 43 SESDQDERGDSGQPSNKELFGDDSEDEGASHHS-GSDNHSERSDNRSEASERSDHEDNDP 101
SE ++ +G Q L +D D S GSD+H S + +D
Sbjct: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
Query: 102 SDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQN 161
D + SG + DD+ S G + G+ + SD++ D+ IQ
Sbjct: 87 DDDEDDSGDDTFGDDD-----SGPGPKDRQEGGNSRLGSDEDS-----------DDTIQA 130
Query: 162 SDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE-------------- 207
S+ E QG D + S+ E + +P+ D ++ SEE
Sbjct: 131 SE-ESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHG 189
Query: 208 -------EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD------------ 248
E SDD + S+ + + NS + + + + N+ D
Sbjct: 190 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR 249
Query: 249 ---ERPQASDEEHRH--SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
+ + S+E+ R D+ ++ KS+S S+S D L R+++ DS+ DS
Sbjct: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS-KGDSQEDSKEN 308
Query: 304 VPKDNSGTMD 313
+ ++ S +D
Sbjct: 309 LSQEESQNVD 318
Score = 38.1 bits (87), Expect = 0.026
Identities = 35/138 (25%), Positives = 53/138 (38%), Gaps = 17/138 (12%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
D ED S+ DS S S S+S +Q ++ S + + SE + D S + L
Sbjct: 361 DQEDSDSSEEDSSHTL--SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
Query: 63 GDDSEDEGASHHSGS--------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---- 110
S E S S S D+ + D+ S S+ S ED +++ S
Sbjct: 419 SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
Query: 111 ---EAPNDDEDEGHRSDG 125
P D+D+ DG
Sbjct: 479 AYHNKPIGDQDDNDCQDG 496
Score = 35.8 bits (81), Expect = 0.13
Identities = 103/531 (19%), Positives = 192/531 (36%), Gaps = 130/531 (24%)
Query: 129 HSEAEGSEK-----AHSDDEKWGREDKSDQSDDEKIQNSDDEE---RAQGSDEDKLQNSD 180
++E+E SE+ A + ED SD + E+ SDD + R G
Sbjct: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
Query: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDD---EKQNSDDEEQPQL 237
DD+ DD+E DD S ++ DD P D + + SD++
Sbjct: 84 DDK-----DDDE-----DD-----SGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS---- 124
Query: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
++ +Q S++ PQ D QD SES R D+ED V DS+
Sbjct: 125 --DDTIQASEESAPQGQDSA---------QDTTSES-RELDNEDRV-----------DSK 161
Query: 298 ADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETR 357
+ + S + GG+D SS D G +D+ G+ Q ++P
Sbjct: 162 PEGGDSTQESESEEHWVGGGSDGESSHGD--------GSELDDEGM----QSDDP----- 204
Query: 358 IEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVE 417
+ ++ GN + S E Q + ++L+ R +
Sbjct: 205 -----ESIRSERGNSR--MNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFR---- 253
Query: 418 NTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGT 477
+ RI +++ +E+ ++N SD + + + + + +GD +
Sbjct: 254 ---KSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLS 310
Query: 478 GLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIK 537
+ Q V S + ++ LS + S++Q+ + G +P+ T ++
Sbjct: 311 QEESQNV---------DGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD-PTTSYVE 360
Query: 538 KEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGG 597
+E+ + E+ LS S E + E ES++
Sbjct: 361 DQEDSDSS------------EEDSSHTLSHSKSESREEQADSESSESLN----------- 397
Query: 598 IREERARIYSSDSDEGSEEDKA--QRLLKAKKLTSDEEGEPSGKRKAEDDD 646
+S +S E E++ + Q L++ +++ + E S +E+DD
Sbjct: 398 --------FSEESPESPEDENSSSQEGLQSHSSSAESQSEES---HSEEDD 437
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 82.8 bits (203), Expect = 9e-16
Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 34/352 (9%)
Query: 8 FGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
F D+ E + D + E S+ G+E ++ GQ +KE +
Sbjct: 4660 FMEDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKE------D 4713
Query: 68 DEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
+ S G DN E S++ D H G +++DE S+GG
Sbjct: 4714 PDSKSDIKGEDNAIEMSED---------------FDGKMHDGELEEQEEDDEKSDSEGGD 4758
Query: 128 ---HHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED--KLQNSDDD 182
H + G E D+ WG + D+ +DE+ +++ EE G DE+ +L DD+
Sbjct: 4759 LDKHMGDLNGEEADKLDERLWGDD---DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDN 4815
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDE---EQPQLSD 239
N++ ++ Q +E+++ ++ +D+ D D +N D Q ++ +
Sbjct: 4816 LDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPE 4875
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAD 299
E + DD + D+ D EE + ++ E+ + + +D
Sbjct: 4876 PEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNES 4935
Query: 300 SDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
+ P++ D G +++ +G+D +D Q +E+ Q Q EE
Sbjct: 4936 QSPQEPEEGPSEDDKAEGEEEMDTGADDQD--GDAAQHPEEHSEEQQQSVEE 4985
Score = 82.0 bits (201), Expect = 2e-15
Identities = 73/340 (21%), Positives = 144/340 (42%), Gaps = 27/340 (7%)
Query: 5 EDLFGSDADSEAE-RKDSDSGSDSDSDQENAASGSNASGSESDQ-DER--GDSGQPSNKE 60
ED G D E E +++ D SDS+ + G + +G E+D+ DER GD + ++E
Sbjct: 4731 EDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMG-DLNGEEADKLDERLWGDDDEEEDEE 4789
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
+ +E+ G + DN + D D + + + ++ ED+
Sbjct: 4790 EEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKI 4849
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSD-----DEERAQGSDEDK 175
+ + E E + H + EK + D DD + + D D + +G +E+
Sbjct: 4850 NEQIDERDYDENE-VDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENP 4908
Query: 176 LQ--------NSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQ 227
L+ + +E+ + D+ Q + + SE++KA ++E +D+ Q
Sbjct: 4909 LEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADD----Q 4964
Query: 228 NSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSD-DEEEQDHKSESARGSDSEDEVLRM 286
+ D + P+ EE+ Q+ +++ +A +E + D+ Q + E SD+E++V
Sbjct: 4965 DGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEA 5024
Query: 287 KRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSD 326
+ AS + + N+ M+L G A + G +
Sbjct: 5025 LERKEHASCGQTGVEN---MQNTQAMELAGAAPEKEQGKE 5061
Score = 66.2 bits (160), Expect = 9e-11
Identities = 82/316 (25%), Positives = 140/316 (44%), Gaps = 65/316 (20%)
Query: 130 SEAEGSEKAHSDD-----EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEK 184
S EG+ + H + E G +D SDQ +E+ Q D ++ Q D++ D D K
Sbjct: 4664 SAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEE-QVEDTFQKGQEKDKE-----DPDSK 4717
Query: 185 MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD----DEEQPQLSDE 240
++ ++S+D ++ + E ++ DDEK +S+ D+ L+ E
Sbjct: 4718 SDIKGEDNAIEMSEDFDGKMHDGELEEQEE--------DDEKSDSEGGDLDKHMGDLNGE 4769
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKS-ESARGSDSEDEVLRMKRKNAIASDSEAD 299
E + DER D+E +DEEE+D+K+ E+ G D ED L K N + +S D
Sbjct: 4770 E--ADKLDERLWGDDDE---EEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKD 4824
Query: 300 SDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIE 359
+ K+ + ADD G GEDK + +DE D+ E +P + +
Sbjct: 4825 KSQQDKKEEKEEAE----ADD---GGQGEDK---INEQIDER--DYDENEVDPYHGNQEK 4872
Query: 360 VEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENT 419
V P+ + LP+ L+++ ED+ E+ +EEG + EN
Sbjct: 4873 VPEPEA----------LDLPDDLNLDS--------EDKNGGEDTDNEEG------EEENP 4908
Query: 420 IRWRIRRDEEGNEIKE 435
+ + + +E G+E +E
Sbjct: 4909 LEIKEKPEEAGHEAEE 4924
Score = 63.5 bits (153), Expect = 6e-10
Identities = 84/390 (21%), Positives = 154/390 (39%), Gaps = 57/390 (14%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
E E D + DS+ +N G E +E G+ P + + E A H
Sbjct: 4875 EPEALDLPDDLNLDSEDKN--------GGEDTDNEEGEEENPLEIK-----EKPEEAGHE 4921
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPND--DEDEGHRSDGGSHHSEA 132
+ +E N S++ + + PS+ D+ G E + D+ +G + HSE
Sbjct: 4922 AEERGETETDQNESQSPQEPEE---GPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEE 4978
Query: 133 EGS---EKAHSDDEKWGREDKSDQS----DDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
+ EK DE+ G +DQ ++E+ ++SD EE+ + E K S +
Sbjct: 4979 QQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGV 5038
Query: 186 QNTDDEERPQLSD--DERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKM 243
+N + + +L+ E++Q EE + + D A+ + + N + Q +
Sbjct: 5039 ENMQNTQAMELAGAAPEKEQGKEEHGSGAAD----ANQAEGHESNFIAQLASQKHTRKNT 5094
Query: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
Q+ + QA +E R D E+ HK +DS E ++ A D++A +
Sbjct: 5095 QSFKRKPGQADNE--RSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIK 5152
Query: 304 VPKD--NSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEE----------- 350
D ++ T D+ S+ G+D+ + +++ + ++QEE
Sbjct: 5153 QGSDAYDAQTYDVASKEQQQSAKDSGKDQEE---EEIEDTLMDTEEQEEFKAADVEQLKP 5209
Query: 351 --------EPIPETRIEVEIPKVNTDLGND 372
P+ +EVEI V T+ D
Sbjct: 5210 EEIKSGTTAPLGFDEMEVEIQTVKTEEDQD 5239
Score = 54.7 bits (130), Expect = 3e-07
Identities = 67/338 (19%), Positives = 140/338 (41%), Gaps = 54/338 (15%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
+ SE ++ + + D+ +D ++ G A E +E+ S + +KE + E+
Sbjct: 4943 EGPSEDDKAEGEEEMDTGADDQD---GDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGP 4999
Query: 71 ASHHSGSDNHSERSDNRSE-----ASERSDHEDNDPSDVDQHSGSEA-------PNDDED 118
A ER D+ +E A ER +H + V+ ++A P ++
Sbjct: 5000 ADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQG 5059
Query: 119 EGHRSDGGSHHSEAEGSE---------KAHSDDEKWGREDKSDQSDDEKIQNSDDE---E 166
+ G + ++AEG E + H+ + K Q+D+E+ +E +
Sbjct: 5060 KEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHK 5119
Query: 167 RAQGSDED-------------KLQNSDDDEKMQNTDDEERPQLSD--DERQQLSEEEKAN 211
R + D D +++++D E ++ D Q D + QQ S ++
Sbjct: 5120 RLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGK 5179
Query: 212 SDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQ----NSDDERPQASDE---EHRHSDDE 264
+E + +D +++++E+ + +D E+++ S P DE E + E
Sbjct: 5180 DQEEEEI----EDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTE 5235
Query: 265 EEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
E+QD +++ A ++E+E R++ I + + DT
Sbjct: 5236 EDQDPRTDKAH-KETENEKPERSRESTIHTAHQFLMDT 5272
Score = 53.9 bits (128), Expect = 5e-07
Identities = 74/383 (19%), Positives = 144/383 (37%), Gaps = 47/383 (12%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDE-----RGDSGQPS 57
D ED G + E ++ + + +E +E+DQ+E + G
Sbjct: 4888 DSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSE 4947
Query: 58 NKELFGDDSEDEGASHHSG--SDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPND 115
+ + G++ D GA G + + E S+ + ++ E D E D+ G P D
Sbjct: 4948 DDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKE------ADEEGGENGPAD 5001
Query: 116 D----EDEGHRSDGGSHHSEAEGSE-KAHSDDEKWGRED--------------KSDQSDD 156
++E R D + E E K H+ + G E+ + +Q +
Sbjct: 5002 QGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKE 5061
Query: 157 EKIQNSDDEERAQGSDEDKL-QNSDDDEKMQNTDD-EERPQLSDDERQQLSEEEKANSDD 214
E + D +A+G + + + Q + +NT + +P +D+ER E+ +
Sbjct: 5062 EHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHK-R 5120
Query: 215 ERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESA 274
R V +D+ E Q + Q Q+ D + ++ + + + E++Q K
Sbjct: 5121 LRTVDTDSHAE-QGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDS-- 5177
Query: 275 RGSDSEDEVLR------MKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGE 328
G D E+E + +++ A+D E E+ + + +I + E
Sbjct: 5178 -GKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEE 5236
Query: 329 DKPP--TPGQPVDENGLPQDQQE 349
D+ P EN P+ +E
Sbjct: 5237 DQDPRTDKAHKETENEKPERSRE 5259
Score = 34.7 bits (78), Expect = 0.29
Identities = 32/142 (22%), Positives = 59/142 (41%), Gaps = 18/142 (12%)
Query: 531 QRTEMIKKEEERLRASIRRESQQRRMRE----KQHQRGLSASYLEPDRYDEEEEGEESIS 586
Q+ + KE+ ++ I+ E M E K H L ++EE+ E+S S
Sbjct: 4704 QKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGELE---------EQEEDDEKSDS 4754
Query: 587 LAAIKNRYKGGIREERA-----RIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRK 641
+++ G + E A R++ D +E EE++ + + +E+ E K
Sbjct: 4755 EGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDD 4814
Query: 642 AEDDDKANKKHKKYVISDEEEE 663
D +NK + +E+EE
Sbjct: 4815 NLDSGNSNKDKSQQDKKEEKEE 4836
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 80.1 bits (196), Expect = 6e-15
Identities = 70/299 (23%), Positives = 129/299 (43%), Gaps = 18/299 (6%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
+ E+E G + Q+ + G+ GSE D ++ S K+ +D E+ G +
Sbjct: 464 EKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKK-----ESKKKTLKNDCEENGLA 518
Query: 73 HHSGSD--NHSERSDNRSEASERSDHE---DNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
S D SE ++ SE D E D D S+ GSE + E+ G D
Sbjct: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE--REFEENGLEKDLDE 576
Query: 128 HHSEAEGSEKAHSDDEKWGREDKSDQSDD--EKIQNSDDEERAQGSDEDKLQNSDDD-EK 184
SE E E + + + S+ DD EK+ + + ER D D+ + +D EK
Sbjct: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
Query: 185 M--QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
+ +D++E + +D++ + ++++ D + + ++DD++ D ++ + +DE K
Sbjct: 637 VFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-K 695
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSD 301
+ DD + DEE S+ + + + G S +E + I S + D D
Sbjct: 696 LFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 74.3 bits (181), Expect = 3e-13
Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 65/340 (19%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
E E S++ + S ++ A G SE +RG G S KE E +
Sbjct: 439 EFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKE-------SEEGNPV 491
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
GS+ S + +++ + ++D E+N + E+ +D E G + SE +
Sbjct: 492 RGSEEDSPKKESKKKTL-KNDCEENGLA-------KESEDDLNKESEEEVGPTKESEEDD 543
Query: 135 SEKAHSDD--EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
SEK +D EK + + ++ ++ DEE GS+++ +N D E +N D E
Sbjct: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE---GSEKELHENVLDKELEEN--DSE 598
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ DD +++ +EE + ER D+D++++ D E+ DDE +
Sbjct: 599 NSEFEDDGSEKVLDEEGS----EREFDEDSDEKEEEEDTYEKV----------FDDESDE 644
Query: 253 ASDEEH-----------------------RHSDDEEEQDHKSESARGSDSEDEVLRMKRK 289
DEE+ SDD+E++D ++ D+++++
Sbjct: 645 KEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED--ADGKEVEDADEKLFEDDDS 702
Query: 290 NAIASDSEADSDTEV--PKDNSGTMDLFGGADD--ISSGS 325
N D E DS ++ D GT+ FG ++ +S+GS
Sbjct: 703 NEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGS 742
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/291 (24%), Positives = 123/291 (42%), Gaps = 45/291 (15%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
GS + E+E + GS+ DS ++ S ++D +E G + S +L + E+
Sbjct: 478 GSCSQKESEEGNPVRGSEEDSPKKE----SKKKTLKNDCEENG-LAKESEDDLNKESEEE 532
Query: 69 EGASHHSGSDNHSERSDN------RSEASERSDHEDNDPSDVDQHSGSEAP--------- 113
G + S D+ + SD + SER E+ D+D+ GSE
Sbjct: 533 VGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE-GSEKELHENVLDKE 591
Query: 114 ---NDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGRE----------DKSDQSDDEKIQ 160
ND E+ DG + EGSE+ +D E D+SD+ +DE+
Sbjct: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
Query: 161 NSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVAS 220
DE+ + +D+ K + D DEK+ D++ + +D + + ++E+ DD
Sbjct: 652 ---DEKGLEAADK-KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
Query: 221 DNDD---EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD 268
D ++ EK D +E+ L S +E P ++ S D+++ D
Sbjct: 708 DEEEDSSEKLFDDSDERGTLGG----FGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 65.9 bits (159), Expect = 1e-10
Identities = 84/376 (22%), Positives = 149/376 (39%), Gaps = 49/376 (13%)
Query: 60 ELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---EAPNDD 116
E F + E S S + SER+ S A S+H + + + E P D+
Sbjct: 370 EAFLNAPEANRGLRRSDSVSASERA-GPSRARHFSEHPSTSKMNAQETATGMAFEEPIDE 428
Query: 117 EDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKI-----------QNSDDE 165
+ DGG A + S EK E ++ +E + S++
Sbjct: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
Query: 166 ERAQGSDEDKLQNSDDDEKMQNTDDEER-PQLSDDERQQLSEEE----KANSDDERPVAS 220
+GS+ED + + ++N +E + S+D+ + SEEE K + +D+ S
Sbjct: 489 NPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKES 548
Query: 221 DNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSE 280
D D ++ S+D + + + ++ D+E + E H + D+E +++ SE++ D
Sbjct: 549 DEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK--ELHENVLDKELEENDSENSEFEDDG 606
Query: 281 DEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 340
E K + S+ E D D++ ++ T + DD S + E+ DE
Sbjct: 607 SE----KVLDEEGSEREFDEDSDEKEEEEDTYEKV--FDDESDEKEDEEY-------ADE 653
Query: 341 NGLP--QDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEF 398
GL + EE E E K + D E D + +ED+
Sbjct: 654 KGLEAADKKAEEGDADEKLFEESDDKEDEDADGK------------EVEDADEKLFEDDD 701
Query: 399 EDEEMLDEEGRTRLKL 414
+E++ DEE + KL
Sbjct: 702 SNEKLFDEEEDSSEKL 717
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/360 (18%), Positives = 136/360 (37%), Gaps = 24/360 (6%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG------QPSNKELFGDDS 66
++ ER++ G ++ + A G S S S + G S PS ++ ++
Sbjct: 357 ETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQET 416
Query: 67 EDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGG 126
A + E++++ E E + + S ++ + P + +EG G
Sbjct: 417 ATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGF 476
Query: 127 SHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM- 185
+ SE+ + + ED + +K +D EE + + N + +E++
Sbjct: 477 EGSCSQKESEEGNP--VRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVG 534
Query: 186 ---QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEE-----QPQL 237
++ +D+ + +D ++ SE+ +E + D D+E + E + +
Sbjct: 535 PTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEE 594
Query: 238 SDEEKMQNSDDERPQASDEE--HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
+D E + DD + DEE R D++ ++ + E +DE K A +
Sbjct: 595 NDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDE-SDEKEDEEYADE 653
Query: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPE 355
++ + ++ LF +DD + ED + DE D E+ E
Sbjct: 654 KGLEAADKKAEEGDADEKLFEESDD----KEDEDADGKEVEDADEKLFEDDDSNEKLFDE 709
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/339 (20%), Positives = 133/339 (39%), Gaps = 49/339 (14%)
Query: 128 HHSEAEGSEKAHSDDEKWGR--EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
H SE + K ++ + G E+ D+ EK ++ + E +G+ E+ + S +++
Sbjct: 401 HFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFE--EGASENNAKESSPEKEA 458
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK--M 243
+ E+ + +R + S++ PV +D + ++ + EE
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARG---SDSEDEVLRMKRKNAIASDSEADS 300
+ S+D+ + S+EE + + EE D + ES SED R +N + D + +
Sbjct: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEG 578
Query: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 360
+ +N +L ++ S S+ ED + +DE G ++ E+ E
Sbjct: 579 SEKELHENVLDKEL---EENDSENSEFEDDGSE--KVLDEEGSEREFDEDSDEKEEE--- 630
Query: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVE--- 417
D Y + FD + DE EDEE DE+G K E
Sbjct: 631 ----------EDTY-----------EKVFDDE--SDEKEDEEYADEKGLEAADKKAEEGD 667
Query: 418 ------NTIRWRIRRDEEGNEIKESNARIVKWSDGSMSL 450
+ D +G E+++++ ++ + D + L
Sbjct: 668 ADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKL 706
Score = 36.6 bits (83), Expect = 0.077
Identities = 42/174 (24%), Positives = 71/174 (40%), Gaps = 25/174 (14%)
Query: 512 CSKTQKIRILPMAGRDPECQRTEMIKK--EEERLRASIRRESQQRRMREKQHQRGLSASY 569
CS+ + P+ G + + + E KK + + + +ES+ +E + + G +
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTK-- 537
Query: 570 LEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDE-GSEEDKAQRLLKAKKL 628
E + D E+E +E S K G RE D DE GSE++ + +L +
Sbjct: 538 -ESEEDDSEKESDEDCSE---KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE 593
Query: 629 TSDEEG---EPSGKRKA-----------EDDDKANKKHKKY--VISDEEEEDDD 666
+D E E G K ED D+ ++ Y V DE +E +D
Sbjct: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKED 647
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 5/101 (4%)
Query: 566 SASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKA 625
+A P++ EE E+ K ++G ++ + + GSEED ++ ++
Sbjct: 448 NAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE--EGNPVRGSEEDSPKK--ES 503
Query: 626 KKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
KK T + E +G K +DD NK+ ++ V +E E+DD
Sbjct: 504 KKKTLKNDCEENGLAKESEDD-LNKESEEEVGPTKESEEDD 543
Score = 34.7 bits (78), Expect = 0.29
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 23/134 (17%)
Query: 539 EEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGI 598
EE L + E ++ + E + L + E + E++G E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSEF--EDDGSEKVL-----------D 612
Query: 599 REERARIYSSDSDEGSEEDKAQRLL-------KAKKLTSDEEGEPSGKRKAEDDDKANKK 651
E R + DSDE EE+ + K + +DE+G + +KAE+ D K
Sbjct: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672
Query: 652 HKKYVISDEEEEDD 665
++ SD++E++D
Sbjct: 673 FEE---SDDKEDED 683
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 80.1 bits (196), Expect = 6e-15
Identities = 70/299 (23%), Positives = 129/299 (43%), Gaps = 18/299 (6%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
+ E+E G + Q+ + G+ GSE D ++ S K+ +D E+ G +
Sbjct: 464 EKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKK-----ESKKKTLKNDCEENGLA 518
Query: 73 HHSGSD--NHSERSDNRSEASERSDHE---DNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
S D SE ++ SE D E D D S+ GSE + E+ G D
Sbjct: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE--REFEENGLEKDLDE 576
Query: 128 HHSEAEGSEKAHSDDEKWGREDKSDQSDD--EKIQNSDDEERAQGSDEDKLQNSDDD-EK 184
SE E E + + + S+ DD EK+ + + ER D D+ + +D EK
Sbjct: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
Query: 185 M--QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
+ +D++E + +D++ + ++++ D + + ++DD++ D ++ + +DE K
Sbjct: 637 VFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-K 695
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSD 301
+ DD + DEE S+ + + + G S +E + I S + D D
Sbjct: 696 LFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 74.3 bits (181), Expect = 3e-13
Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 65/340 (19%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
E E S++ + S ++ A G SE +RG G S KE E +
Sbjct: 439 EFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKE-------SEEGNPV 491
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
GS+ S + +++ + ++D E+N + E+ +D E G + SE +
Sbjct: 492 RGSEEDSPKKESKKKTL-KNDCEENGLA-------KESEDDLNKESEEEVGPTKESEEDD 543
Query: 135 SEKAHSDD--EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
SEK +D EK + + ++ ++ DEE GS+++ +N D E +N D E
Sbjct: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE---GSEKELHENVLDKELEEN--DSE 598
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ DD +++ +EE + ER D+D++++ D E+ DDE +
Sbjct: 599 NSEFEDDGSEKVLDEEGS----EREFDEDSDEKEEEEDTYEKV----------FDDESDE 644
Query: 253 ASDEEH-----------------------RHSDDEEEQDHKSESARGSDSEDEVLRMKRK 289
DEE+ SDD+E++D ++ D+++++
Sbjct: 645 KEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED--ADGKEVEDADEKLFEDDDS 702
Query: 290 NAIASDSEADSDTEV--PKDNSGTMDLFGGADD--ISSGS 325
N D E DS ++ D GT+ FG ++ +S+GS
Sbjct: 703 NEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGS 742
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/291 (24%), Positives = 123/291 (42%), Gaps = 45/291 (15%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
GS + E+E + GS+ DS ++ S ++D +E G + S +L + E+
Sbjct: 478 GSCSQKESEEGNPVRGSEEDSPKKE----SKKKTLKNDCEENG-LAKESEDDLNKESEEE 532
Query: 69 EGASHHSGSDNHSERSDN------RSEASERSDHEDNDPSDVDQHSGSEAP--------- 113
G + S D+ + SD + SER E+ D+D+ GSE
Sbjct: 533 VGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE-GSEKELHENVLDKE 591
Query: 114 ---NDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGRE----------DKSDQSDDEKIQ 160
ND E+ DG + EGSE+ +D E D+SD+ +DE+
Sbjct: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
Query: 161 NSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVAS 220
DE+ + +D+ K + D DEK+ D++ + +D + + ++E+ DD
Sbjct: 652 ---DEKGLEAADK-KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
Query: 221 DNDD---EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD 268
D ++ EK D +E+ L S +E P ++ S D+++ D
Sbjct: 708 DEEEDSSEKLFDDSDERGTLGG----FGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 65.9 bits (159), Expect = 1e-10
Identities = 84/376 (22%), Positives = 149/376 (39%), Gaps = 49/376 (13%)
Query: 60 ELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---EAPNDD 116
E F + E S S + SER+ S A S+H + + + E P D+
Sbjct: 370 EAFLNAPEANRGLRRSDSVSASERA-GPSRARHFSEHPSTSKMNAQETATGMAFEEPIDE 428
Query: 117 EDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKI-----------QNSDDE 165
+ DGG A + S EK E ++ +E + S++
Sbjct: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
Query: 166 ERAQGSDEDKLQNSDDDEKMQNTDDEER-PQLSDDERQQLSEEE----KANSDDERPVAS 220
+GS+ED + + ++N +E + S+D+ + SEEE K + +D+ S
Sbjct: 489 NPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKES 548
Query: 221 DNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSE 280
D D ++ S+D + + + ++ D+E + E H + D+E +++ SE++ D
Sbjct: 549 DEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK--ELHENVLDKELEENDSENSEFEDDG 606
Query: 281 DEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 340
E K + S+ E D D++ ++ T + DD S + E+ DE
Sbjct: 607 SE----KVLDEEGSEREFDEDSDEKEEEEDTYEKV--FDDESDEKEDEEY-------ADE 653
Query: 341 NGLP--QDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEF 398
GL + EE E E K + D E D + +ED+
Sbjct: 654 KGLEAADKKAEEGDADEKLFEESDDKEDEDADGK------------EVEDADEKLFEDDD 701
Query: 399 EDEEMLDEEGRTRLKL 414
+E++ DEE + KL
Sbjct: 702 SNEKLFDEEEDSSEKL 717
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/360 (18%), Positives = 136/360 (37%), Gaps = 24/360 (6%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG------QPSNKELFGDDS 66
++ ER++ G ++ + A G S S S + G S PS ++ ++
Sbjct: 357 ETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQET 416
Query: 67 EDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGG 126
A + E++++ E E + + S ++ + P + +EG G
Sbjct: 417 ATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGF 476
Query: 127 SHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM- 185
+ SE+ + + ED + +K +D EE + + N + +E++
Sbjct: 477 EGSCSQKESEEGNP--VRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVG 534
Query: 186 ---QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEE-----QPQL 237
++ +D+ + +D ++ SE+ +E + D D+E + E + +
Sbjct: 535 PTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEE 594
Query: 238 SDEEKMQNSDDERPQASDEE--HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
+D E + DD + DEE R D++ ++ + E +DE K A +
Sbjct: 595 NDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDE-SDEKEDEEYADE 653
Query: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPE 355
++ + ++ LF +DD + ED + DE D E+ E
Sbjct: 654 KGLEAADKKAEEGDADEKLFEESDD----KEDEDADGKEVEDADEKLFEDDDSNEKLFDE 709
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/339 (20%), Positives = 133/339 (39%), Gaps = 49/339 (14%)
Query: 128 HHSEAEGSEKAHSDDEKWGR--EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
H SE + K ++ + G E+ D+ EK ++ + E +G+ E+ + S +++
Sbjct: 401 HFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFE--EGASENNAKESSPEKEA 458
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK--M 243
+ E+ + +R + S++ PV +D + ++ + EE
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARG---SDSEDEVLRMKRKNAIASDSEADS 300
+ S+D+ + S+EE + + EE D + ES SED R +N + D + +
Sbjct: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEG 578
Query: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 360
+ +N +L ++ S S+ ED + +DE G ++ E+ E
Sbjct: 579 SEKELHENVLDKEL---EENDSENSEFEDDGSE--KVLDEEGSEREFDEDSDEKEEE--- 630
Query: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVE--- 417
D Y + FD + DE EDEE DE+G K E
Sbjct: 631 ----------EDTY-----------EKVFDDE--SDEKEDEEYADEKGLEAADKKAEEGD 667
Query: 418 ------NTIRWRIRRDEEGNEIKESNARIVKWSDGSMSL 450
+ D +G E+++++ ++ + D + L
Sbjct: 668 ADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKL 706
Score = 36.6 bits (83), Expect = 0.077
Identities = 42/174 (24%), Positives = 71/174 (40%), Gaps = 25/174 (14%)
Query: 512 CSKTQKIRILPMAGRDPECQRTEMIKK--EEERLRASIRRESQQRRMREKQHQRGLSASY 569
CS+ + P+ G + + + E KK + + + +ES+ +E + + G +
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTK-- 537
Query: 570 LEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDE-GSEEDKAQRLLKAKKL 628
E + D E+E +E S K G RE D DE GSE++ + +L +
Sbjct: 538 -ESEEDDSEKESDEDCSE---KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE 593
Query: 629 TSDEEG---EPSGKRKA-----------EDDDKANKKHKKY--VISDEEEEDDD 666
+D E E G K ED D+ ++ Y V DE +E +D
Sbjct: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKED 647
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 5/101 (4%)
Query: 566 SASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKA 625
+A P++ EE E+ K ++G ++ + + GSEED ++ ++
Sbjct: 448 NAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE--EGNPVRGSEEDSPKK--ES 503
Query: 626 KKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
KK T + E +G K +DD NK+ ++ V +E E+DD
Sbjct: 504 KKKTLKNDCEENGLAKESEDD-LNKESEEEVGPTKESEEDD 543
Score = 34.7 bits (78), Expect = 0.29
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 23/134 (17%)
Query: 539 EEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGI 598
EE L + E ++ + E + L + E + E++G E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSEF--EDDGSEKVL-----------D 612
Query: 599 REERARIYSSDSDEGSEEDKAQRLL-------KAKKLTSDEEGEPSGKRKAEDDDKANKK 651
E R + DSDE EE+ + K + +DE+G + +KAE+ D K
Sbjct: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672
Query: 652 HKKYVISDEEEEDD 665
++ SD++E++D
Sbjct: 673 FEE---SDDKEDED 683
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 77.8 bits (190), Expect = 3e-14
Identities = 81/426 (19%), Positives = 158/426 (37%), Gaps = 50/426 (11%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
+ E ER+ + + ++E E +++ D + ++ D D
Sbjct: 311 ERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRD 370
Query: 73 HHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEA 132
SD + +RS +R ++ +R + E + E E R E
Sbjct: 371 RERSSDRNKDRSRSREKSRDRERERER-----------ERERERERERERERERERERER 419
Query: 133 EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
E + D ++ ED+ D + K++ E+ A + +++L+N + E+ + + E+
Sbjct: 420 EREREREKDKKRDREEDEEDAYERRKLERKLREKEA--AYQERLKNWEIRERKKTREYEK 477
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ ++ R+++++E K + D DD K Q +L D EK +D+ +
Sbjct: 478 EAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRK 537
Query: 253 ASDEE----------HRHSDDEEEQDHKSESA----------RGSDSEDEVLRMKRKNAI 292
EE H D + E + A E+E + +++
Sbjct: 538 REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
Query: 293 ASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQP------VDENGLPQD 346
E + + E T+ A +SS S G P TPG + P
Sbjct: 598 EEPMEEEEEPEQKPCLKPTLRPISSAPSVSSAS-GNATPNTPGDESPCGIIIPHENSPDQ 656
Query: 347 QQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDE 406
QQ EE P+ + +++ N+ PN + + P D + ++FEDE+ D
Sbjct: 657 QQPEEHRPKIGLSLKLGASNSP--------GQPNSVKRKKLPVDSVF--NKFEDEDSDDV 706
Query: 407 EGRTRL 412
+ +L
Sbjct: 707 PRKRKL 712
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/174 (19%), Positives = 73/174 (41%), Gaps = 14/174 (8%)
Query: 126 GSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
G E + EK + E+ ++ + + + + + E+ + + ++ ++ D D
Sbjct: 296 GKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTK 355
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
+ D +R + D +R++ S+ K D ++ S D E+ + + E+ +
Sbjct: 356 ERDRDRDRERDRDRDRERSSDRNK-----------DRSRSREKSRDRERERERERERERE 404
Query: 246 SDDERPQASDEEH-RHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEA 298
+ ER + + E R + E E+D K + R D ED R K + + A
Sbjct: 405 REREREREREREREREREREREKDKKRD--REEDEEDAYERRKLERKLREKEAA 456
Score = 44.7 bits (104), Expect = 3e-04
Identities = 33/163 (20%), Positives = 71/163 (43%), Gaps = 10/163 (6%)
Query: 147 REDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSE 206
RE + +K++ ++ + + +K + + E+ + + ER + + ER++ E
Sbjct: 279 REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKE 338
Query: 207 EEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASD---------EE 257
+E+ + ER D E+ D E+ + D E+ + + +R ++ + E
Sbjct: 339 KERER-ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERER 397
Query: 258 HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 300
R + E E++ + E R + E E R K K + E D+
Sbjct: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/212 (16%), Positives = 86/212 (40%), Gaps = 7/212 (3%)
Query: 92 ERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKS 151
E S D ++ E + ++ R E E E+ + + RE +
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEK 339
Query: 152 DQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKAN 211
++ + + D + + D D+ ++ D D + + +++R + + R + E E+
Sbjct: 340 ERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERER-- 397
Query: 212 SDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKS 271
+ ER + + E++ + E+ + + E+ + D +R + DEE + + E+ +
Sbjct: 398 -ERER----EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLRE 452
Query: 272 ESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
+ A + +RK + EA+ + E
Sbjct: 453 KEAAYQERLKNWEIRERKKTREYEKEAEREEE 484
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/312 (17%), Positives = 111/312 (35%), Gaps = 33/312 (10%)
Query: 82 ERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSD 141
ER + E ER + + ++ E + E E R + + +++ D
Sbjct: 301 ERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRD 360
Query: 142 DEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDER 201
+ RE D+ + + D R++ D+ + + + + + + ER + + ER
Sbjct: 361 RD---RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
Query: 202 QQLSEEEKANSDDERPVASDNDD------------EKQNSDDEEQPQLSDEEKMQNSDDE 249
++ E E+ D +R D +D EK+ + E E+ + + E
Sbjct: 418 ERERERER-EKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE 476
Query: 250 RPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV-----------LRMKRKNAIASDSEA 298
+ +EE R +E + K D D+ LR + K A + +
Sbjct: 477 KEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDR 536
Query: 299 DSDTEVPKD------NSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEP 352
+ E ++ G D + ++ +P +P E + Q++EE
Sbjct: 537 KREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK 596
Query: 353 IPETRIEVEIPK 364
E E E P+
Sbjct: 597 REEPMEEEEEPE 608
Score = 40.8 bits (94), Expect = 0.004
Identities = 35/169 (20%), Positives = 74/169 (43%), Gaps = 15/169 (8%)
Query: 153 QSDDEKIQNSDDEERAQGSDEDKLQNSDDD-EKMQNTDDEERPQLSDD----ERQQLSEE 207
+ D I+ +D+ + K +++ E+ + ++ER ++ + ER++ E
Sbjct: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDD---- 263
E+ + ER + + EK+ + E+ + D K ++ D +R + D + S D
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
Query: 264 -----EEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKD 307
E+ +D + E R + E E R +R+ + E + + E KD
Sbjct: 381 RSRSREKSRDRERERERERERERERER-EREREREREREREREREREKD 428
Score = 40.4 bits (93), Expect = 0.005
Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 9/142 (6%)
Query: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
EDK D E + D ++ + K + + EK + + ER + ER++ E
Sbjct: 271 EDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERER----ERERRERE 326
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
+ + ER + + E++ D ++ + D ++ D ER + D E R SD +++
Sbjct: 327 REREREREREKEKERERERERDRDRDRTKERDRDR----DRERDRDRDRE-RSSDRNKDR 381
Query: 268 DHKSESARGSDSEDEVLRMKRK 289
E +R + E E R + +
Sbjct: 382 SRSREKSRDRERERERERERER 403
Score = 39.7 bits (91), Expect = 0.009
Identities = 62/276 (22%), Positives = 113/276 (40%), Gaps = 23/276 (8%)
Query: 399 EDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFD 458
+DEE LDEE + R ++ ++ I IR E +E+ + SD + D
Sbjct: 191 DDEEALDEETKRRDQM-IKGAIEVLIR--EYSSELNAPSQE----SDSHPRKKKKEKKED 243
Query: 459 VYK----APLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSK 514
+++ APL L ++ K L R S TH+K+ + +
Sbjct: 244 IFRRFPVAPLIP--YPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKE 301
Query: 515 TQKIRILPMAGRDPECQRT-EMIKKEEERLRASIR-RESQQRRMREKQHQRGLSASYLEP 572
Q+I R+ E +R E ++E ER R R RE ++ R RE++ R +
Sbjct: 302 RQEIE---KERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 573 DRYDEEEEGEESISLAAIKNRYKGGIRE-----ERARIYSSDSDEGSEEDKAQRLLKAKK 627
D E + + ++ +N+ + RE ER R + + E ++ + + ++
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE 418
Query: 628 LTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEE 663
+ E E KR E+D++ + +K E+E
Sbjct: 419 REREREREKDKKRDREEDEEDAYERRKLERKLREKE 454
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/143 (25%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 537 KKEEERLR-ASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEE---EGEESISLAAIKN 592
KKE+ER RRE ++ R RE++ + E +R E+E E E K
Sbjct: 297 KKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKE 356
Query: 593 RYKGGIRE---ERARIYSSDSDEG------SEEDKAQRLLKAKKLTSDEEGEPSGKRKAE 643
R + RE +R R SSD ++ D+ + + ++ + E E +R+ E
Sbjct: 357 RDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE 416
Query: 644 DDDKANKKHKKYVISDEEEEDDD 666
+ + ++ +K D EE+++D
Sbjct: 417 REREREREREKDKKRDREEDEED 439
Score = 32.7 bits (73), Expect = 1.1
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 22/160 (13%)
Query: 526 RDPECQRTEMIKKEEERLRASIRR-ESQQRRMREKQHQRGLSASYLEP--DRYDEEEEGE 582
R+ E E +K E R R R E + R E++ + A L+ + YD++ +
Sbjct: 451 REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDP 510
Query: 583 ESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEE--------- 633
+ +A++ R + +E A ++ E+ QRLL D E
Sbjct: 511 KYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAE 570
Query: 634 --------GEPSGKRKAEDDDKANKKHKKYVISDEEEEDD 665
EP + E+++K K+ K+ +EEEE +
Sbjct: 571 RRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEEPE 608
Score = 32.0 bits (71), Expect = 1.9
Identities = 39/152 (25%), Positives = 58/152 (38%), Gaps = 15/152 (9%)
Query: 526 RDPECQRTEMIKKEEERLRASIR-----RESQQRRMREKQHQRGLSASYLEPDRYDEEEE 580
R+ E +R +++ +R R R RE + R RE+ R S D E E
Sbjct: 335 REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE 394
Query: 581 GEESISLAAIKNRYKGGIRE---ERARIYSSDSD-----EGSEEDKAQRLLKAKKLTSDE 632
E + R + RE ER R + D E EED +R +KL E
Sbjct: 395 REREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKE 454
Query: 633 EGEPSGKRKAEDDDKANKKHKKYVISDEEEED 664
+R + + KK ++Y E EE+
Sbjct: 455 AAYQ--ERLKNWEIRERKKTREYEKEAEREEE 484
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 76.3 bits (186), Expect = 9e-14
Identities = 107/535 (20%), Positives = 215/535 (40%), Gaps = 76/535 (14%)
Query: 58 NKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDE 117
++ + D +E+E S++ ER + + ++ ND D +++ + ++E
Sbjct: 134 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE 193
Query: 118 DEGHRSDG--GSHHSEAEGSEK-AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED 174
+E G G + E EK S +E K+ Q E + +EER QGSDE
Sbjct: 194 EEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE--EPKQEEEREQGSDE- 250
Query: 175 KLQNSDDDEKMQNTDDE----ERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
EKM+ D E ER +L +ER+++ E+ DER A +EK +
Sbjct: 251 ----ISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADER--ARIEAEEKAAAQ 304
Query: 231 DEEQPQLSDEEKMQNSD----DERPQASDEEHRHSDDEE---EQDHKSESARGSDSEDEV 283
+ E+ + + E+M+ + +ER + +EE R +++ + E++ ++ R E+E
Sbjct: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 364
Query: 284 LRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDIS-SGSDGEDKPPTPGQPVDENG 342
+ + ++ E + E K N + + G E K G+ V+E
Sbjct: 365 RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK--IEGKWVNEKK 422
Query: 343 LPQDQQEEEPIPE------TRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYED 396
+D+ + + + T+++ + K+ D P + ++
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQED---------------------KPTFKKE 461
Query: 397 EFEDEEM-LDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNE 455
E +DE++ D+E + +K ++ R + E+K N G H
Sbjct: 462 EIKDEKIKKDKEPKEEVKSFMD--------RKKGFTEVKSQN--------GEFMTHKLKH 505
Query: 456 VFDVYKAPLQGDHNHLFIRQGTGLQGQAVFK--TKLTFRPHSTDSATHRKMTLSLADRCS 513
+ + P G + ++ G K +L R T+S K+ +
Sbjct: 506 TENTFSRP--GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL 563
Query: 514 KTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSAS 568
+ ++++ R + E +K+EE R +R E ++RR++E+ +R A+
Sbjct: 564 ELEELK-KKREERRKVLEEEEQRRKQEEADR-KLREEEEKRRLKEEIERRRAEAA 616
Score = 66.6 bits (161), Expect = 7e-11
Identities = 74/355 (20%), Positives = 147/355 (41%), Gaps = 35/355 (9%)
Query: 16 AERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHS 75
AE + ++ S+S QE + ++S Q + + KE + E+E
Sbjct: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE-DKEKEEEEEEKPKR 200
Query: 76 GSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGS 135
GS ++ E + S E S + SE P +E+ SD SHH + E
Sbjct: 201 GSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEE 260
Query: 136 EKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQ 195
+K ++ E+ + + + E+I+ D++ A D+ + +EK +ER +
Sbjct: 261 DKERAEAER----ARLEAEERERIKAEQDKKIA-----DERARIEAEEKAAA---QERER 308
Query: 196 LSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK-----MQNSDDER 250
+ER+++ EEEK +++ + + ++EK+ + EE+ ++ +EEK Q +E
Sbjct: 309 REAEERERMREEEKRAAEERQRI---KEEEKRAA--EERQRIKEEEKRAAEERQRIKEEE 363
Query: 251 PQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSG 310
+A++E R +EEE+ E R E++ M+ E + + +
Sbjct: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423
Query: 311 TMDLFGGADDISSGSD------------GEDKPPTPGQPVDENGLPQDQQEEEPI 353
D A G + EDKP + + + + +D++ +E +
Sbjct: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 478
Score = 44.7 bits (104), Expect = 3e-04
Identities = 90/507 (17%), Positives = 197/507 (38%), Gaps = 59/507 (11%)
Query: 158 KIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERP 217
+++ EE ++ Q +DDDE + E R + + +Q EEE
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDE--EEAARERRRRARQERLRQKQEEESLGQ----- 61
Query: 218 VASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE----RPQASDEEHRHSDDEEEQDHKSES 273
V + QNS +E+ + + DDE A EE R +E + + E
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 274 ARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPT 333
L +R +++E E + ++ S + +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 334 PGQPVDENGLPQDQQEEEP----IPETRIEVEIPKVNTDLGNDLYFVKLPN--FLSVEPR 387
+ D+ ++++EE+P I E ++EV + + T+ + + L N S EP+
Sbjct: 182 ENKKEDKE--KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 388 PFDP-QYYEDEFEDEEMLDEEGRTRL---KLKVENTIRWRIRRDEEGNEIKESNARIVKW 443
+ + DE E ++EE + R + ++E R RI+ E+ +I + ARI
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA-EQDKKIADERARIEA- 297
Query: 444 SDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRK 503
+ A + + R+ + + + + + +A R+
Sbjct: 298 --------------EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 504 MTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQR 563
R ++ ++ RI R E ++ ++EE +A + + + +++ EK+H
Sbjct: 344 RIKEEEKRAAE-ERQRIKEEEKRAAEERQRARAEEEE---KAKVEEQKRNKQLEEKKH-- 397
Query: 564 GLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLL 623
+ + ++ ++ +++ EG+ A +++ + + +++ EE +
Sbjct: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ-----------GEEKGTKVQA 446
Query: 624 KAKKLTSDEEGEPSGKRKAEDDDKANK 650
K +KL +E +P+ K++ D+K K
Sbjct: 447 KREKL---QEDKPTFKKEEIKDEKIKK 470
Score = 41.6 bits (96), Expect = 0.002
Identities = 71/446 (15%), Positives = 161/446 (36%), Gaps = 46/446 (10%)
Query: 3 DMEDLFGSDADSEAERKDSDS-GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
D E+ D + E E ++ GS ++ E E +GQ S++E
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Query: 62 FGDDSEDEGASHHSGSDNHSERSDNRSEAS----------------------ERSDHEDN 99
++ ++G+ S + E R+EA ER+ E
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 100 DPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDD-------EKWGREDKSD 152
+ + + EA + + EK +++ EK E++
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 153 QSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANS 212
++EK + +++ +RA+ +E+K + + Q + + Q + + +++ ++ +
Sbjct: 359 IKEEEK-RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Query: 213 DDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSE 272
+E+ D E+ + K + +++P EE + +++++ K E
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477
Query: 273 SARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPP 332
D + +K +N + T K T GG + + + E P
Sbjct: 478 VKSFMDRKKGFTEVKSQN-------GEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQ 529
Query: 333 T-PGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDP 391
G+ ++E + + E E ++ + + +L +K + +
Sbjct: 530 VEAGKRLEELRRRRGETESEEFE------KLKQKQQEAALELEELKKKREERRKVLEEEE 583
Query: 392 QYYEDEFEDEEMLDEEGRTRLKLKVE 417
Q + E D ++ +EE + RLK ++E
Sbjct: 584 QRRKQEEADRKLREEEEKRRLKEEIE 609
Score = 40.4 bits (93), Expect = 0.005
Identities = 57/284 (20%), Positives = 103/284 (36%), Gaps = 23/284 (8%)
Query: 396 DEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARI----VKWSDGSMSLH 451
D+FE L + R ++L+ E I ++ D+E +E R ++ SL
Sbjct: 2 DDFERRRELRRQKREEMRLEAER-IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 452 LGNEVFDVYKAPLQGDHNHLFIRQGTGLQG--QAVFKTKLTFRPHSTDSATHRKMTLSLA 509
+ +V D T ++G +A F +L R +
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 510 DRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASY 569
+ T LP + E +KEE+ R E ++ K +Q+
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 570 LEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLT 629
E + D+E+E EE + +G I E + + + S+E+ LK +++
Sbjct: 181 EENKKEDKEKEEEEE------EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
Query: 630 SDE----------EGEPSGKRKAEDDDKANKKHKKYVISDEEEE 663
S+E E S K E++DK + ++ + EE E
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE 278
Score = 37.4 bits (85), Expect = 0.045
Identities = 71/426 (16%), Positives = 165/426 (38%), Gaps = 58/426 (13%)
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNA----IASD 295
E + Q ++ R +A ++ +DD+EE+ + R + E LR K++ +
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR---ARQERLRQKQEEESLGQVTDQ 65
Query: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPE 355
E ++ VP + + T ++ +G+D+ ++ ++++++
Sbjct: 66 VEVNAQNSVPDEEAKTTTT-------NTQVEGDDEAAF----LERLARREERRQKRLQEA 114
Query: 356 TRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLK 415
+ E TD LS+ R E+E ++E E + R +++
Sbjct: 115 LERQKEFDPTITDAS-----------LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
Query: 416 VENTIR-------WRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDH 468
T+ WR + + + ++ K GS+ + + + Q +
Sbjct: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223
Query: 469 NHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDP 528
+ ++ G Q + + R +D +H + ++ ++ R+
Sbjct: 224 VVMSLKNG---QISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
Query: 529 ECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLA 588
+ ++ + I E R+ A + +Q+R RE + + + R +E+ EE +
Sbjct: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERM--------REEEKRAAEERQRIK 332
Query: 589 AIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKA 648
+ R EER RI +E ++ QR+ + +K ++E + +AE+++KA
Sbjct: 333 EEEKR----AAEERQRI---KEEEKRAAEERQRIKEEEKRAAEERQ----RARAEEEEKA 381
Query: 649 NKKHKK 654
+ +K
Sbjct: 382 KVEEQK 387
Score = 32.3 bits (72), Expect = 1.4
Identities = 39/197 (19%), Positives = 76/197 (38%), Gaps = 25/197 (12%)
Query: 136 EKAHSDDEKWGRED------KSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD-DEKMQNT 188
EK D + +E+ K D+ E++++ D R +G E K QN + K+++T
Sbjct: 449 EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD--RKKGFTEVKSQNGEFMTHKLKHT 506
Query: 189 DD----------------EERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDE 232
++ E PQ+ +R + + ++ E ++ + E
Sbjct: 507 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
Query: 233 EQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
E + +E + ++E+ + +E R +EEE+ E +E R K
Sbjct: 567 ELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDG 626
Query: 293 ASDSEADSDTEVPKDNS 309
SD + PK +S
Sbjct: 627 LSDDKKPFKCFTPKGSS 643
Score = 32.3 bits (72), Expect = 1.4
Identities = 29/145 (20%), Positives = 62/145 (42%), Gaps = 13/145 (8%)
Query: 83 RSDNRSEASERSDHEDNDPS------DVDQHSGSEAPNDDE----DEGHRSDGGSHHSEA 132
+S N + + H +N S VD AP + +E R G + E
Sbjct: 492 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 551
Query: 133 EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
E ++ + E K + + K+ +++ R Q + KL+ ++ +++ +
Sbjct: 552 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 611
Query: 193 RPQLSDDERQQLSEEEKANSDDERP 217
R + ++ +RQ++ E+ SDD++P
Sbjct: 612 RAEAAE-KRQKMPED--GLSDDKKP 633
Score = 32.0 bits (71), Expect = 1.9
Identities = 31/130 (23%), Positives = 61/130 (46%), Gaps = 14/130 (10%)
Query: 533 TEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKN 592
+E K+EEER + S S +M E+ +R E +R E E E I K
Sbjct: 235 SEEPKQEEEREQGS-DEISHHEKMEEEDKERA------EAERARLEAEERERIKAEQDKK 287
Query: 593 RYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKH 652
I +ERARI + ++ + +++ +R + ++ +EE + +R+ +++
Sbjct: 288 -----IADERARIEA--EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
Query: 653 KKYVISDEEE 662
++ I +EE+
Sbjct: 341 ERQRIKEEEK 350
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 73.6 bits (179), Expect = 6e-13
Identities = 73/385 (18%), Positives = 154/385 (40%), Gaps = 71/385 (18%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQ------------------DERGDSGQ 55
+ +RK +D S S SD E+ S GS +Q GD
Sbjct: 1153 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1212
Query: 56 PSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---EA 112
+ + DD +D+ + + + +S+ D++P + + +G E
Sbjct: 1213 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1272
Query: 113 PNDDEDEGH-RSDGGSHHSEAEGSEKAHS--------DDEKWGREDKSDQSDDEKIQNSD 163
P D+E + S+ S E++ H D + G E K+ + ++++ +
Sbjct: 1273 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN 1332
Query: 164 DEE-RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDER----PV 218
+ ++ S++ Q S E++ ++DE+RP+ ++ +L E +++ ++ V
Sbjct: 1333 RRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKV 1392
Query: 219 ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSD 278
D+ E +++ +EE+ + +EE+ +EE ++E+E D +G
Sbjct: 1393 QEDSSSENKSNSEEEEEEKEEEEE------------EEEEEEEEEEDENDDSKSPGKGRK 1440
Query: 279 S-----EDEVLRMKRKNAIASDSE-----ADSDTEVPKDNSGTMDLFGGADDISSGSDGE 328
+D+ LR + +NA+ + E A+ + E K + + E
Sbjct: 1441 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK--------------LREVIEIE 1486
Query: 329 DKPPTPGQPVDENGLPQDQQEEEPI 353
D PT + L +D++ +EP+
Sbjct: 1487 DASPTKCPITTKLVLDEDEETKEPL 1511
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/231 (19%), Positives = 103/231 (44%), Gaps = 6/231 (2%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQD-ERGDSGQPSNKELFG 63
ED D E +++ ++ D+E N SESD D E + ++ L
Sbjct: 1250 EDGSSDDEPEEGKKRTGKQNEENPGDEE----AKNQVNSESDSDSEESKKPRYRHRLLRH 1305
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
+ +G S E + + + ED++ SD + SE ++ EDE
Sbjct: 1306 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDE 183
+ +E E +++++ +K R + S E NS++EE + +E++ + +++E
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425
Query: 184 KMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
+ +N DD + P + +++ +++K ++ + + + + K+ ++ E +
Sbjct: 1426 EDEN-DDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1475
Score = 60.5 bits (145), Expect = 5e-09
Identities = 159/796 (19%), Positives = 288/796 (36%), Gaps = 175/796 (21%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSE-SDQDERGDSGQPSNKEL 61
D++ G D + +RK S SGSD D+ + +A S S + Q E + KE+
Sbjct: 728 DLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEI 787
Query: 62 FG--------------------DDSEDEGAS--------------HHSGSDNHSERSDNR 87
D SEDE S GS + +ER R
Sbjct: 788 KSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQER 847
Query: 88 SEASERSDHEDNDPSDVD--------QHSGSEAPNDDEDEGHRSDGGS--HHSEAEGSEK 137
S D D + ++ Q + + D+ G S AE EK
Sbjct: 848 ETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEK 907
Query: 138 AH--------------SD-DEKWGREDKSDQS--DDEKIQNSDDEERAQGSD-------- 172
+ SD EK+ ++D+SD++ DD+K EE+ + SD
Sbjct: 908 SKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKM 967
Query: 173 EDKLQNSDD-------------------------------DEKMQNTDDEERPQLSDDER 201
E + ++S D +K+++ +++ +LSD
Sbjct: 968 EQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAE 1027
Query: 202 QQLSEEEKANSDDER--------------PVASDNDDEKQNSDDEEQPQLSDEEKMQNSD 247
+ + + +S +++ + + ++Q+ + + S +E NS
Sbjct: 1028 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1087
Query: 248 DERPQASD-EEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPK 306
D+R + + E R+ + + SD+E+ K+K S + + K
Sbjct: 1088 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1147
Query: 307 DNSGTMDLFGGADDI--SSGSDGEDKPPTPGQPVDENGLPQ---DQQEEEPIPETRIEVE 361
NS DI SS SD ED D+N + + D+Q+ +P+ E +
Sbjct: 1148 RNSLRTSTKRKQADITSSSSSDIEDD--------DQNSIGEGSSDEQKIKPVTENLVLSS 1199
Query: 362 IPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIR 421
G++ +P ++V+ +D++ D E R K+ +E I+
Sbjct: 1200 HTGFCQSSGDEALSKSVP--VTVD-------------DDDDDNDPENRIAKKMLLEE-IK 1243
Query: 422 WRIRRDEEG---NEIKESNARIVKWS-----DGSMSLHLGNEVFDVYKAPLQGDHNHLFI 473
+ DE+G +E +E R K + D + +E + + + H +
Sbjct: 1244 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1303
Query: 474 RQG-TGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILP--MAGRDPEC 530
R T G++ + K + H +R+ S S Q+ + D +
Sbjct: 1304 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1363
Query: 531 QRTEMIKKEE-ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAA 589
RT KK E E + S +++ ++RR++ ++ + S E + ++EEE EE
Sbjct: 1364 PRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE--- 1420
Query: 590 IKNRYKGGIREERARIYSSDS-DEGSEEDKAQRLLKAKKLTSD-----EEGEPSGKRKAE 643
EE + DS G K +++LK KL ++ +E E KR AE
Sbjct: 1421 ---------EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAE 1471
Query: 644 DDDKANKKHKKYVISD 659
+ + K + I D
Sbjct: 1472 REREREKLREVIEIED 1487
Score = 59.3 bits (142), Expect = 1e-08
Identities = 99/504 (19%), Positives = 193/504 (38%), Gaps = 82/504 (16%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNK-ELFGDDSEDEGA 71
D +++KD S D +++ G + SE + + G G+ + +L G S
Sbjct: 1013 DKTSKKKDELS----DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQD 1068
Query: 72 SHHSGSDNHSERSDN---------RSEASERSD--HEDNDPSDVDQHSGSEAPNDDEDEG 120
S ++ +S + D R E ER + + N S S+A ED
Sbjct: 1069 CSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNK 1128
Query: 121 HRSDGGSHHSEAE-GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQG---SDEDKL 176
+ S +A EK + + ++D + DD++ + G SDE K+
Sbjct: 1129 KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1188
Query: 177 Q---------------NSDDDEKMQNT-------DDEERPQLSDDERQQLSEEEKANSDD 214
+ S DE + + DD++ + ++ L EE KAN
Sbjct: 1189 KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSS 1248
Query: 215 ERPVASDNDDE-------KQNS----DDEEQPQLSDEEKMQNSDDERPQASDEEHRH--- 260
+ +SD++ E KQN D+E + Q++ E + + ++P+ RH
Sbjct: 1249 DEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLT 1308
Query: 261 -SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGAD 319
SD E ++ K++ E + ++ + + ++S+ DSD + G
Sbjct: 1309 VSDGESGEEKKTKP-----KEHKEVKGRNRRKVSSEDSEDSDFQE-----------SGVS 1352
Query: 320 DISSGSDGEDKPPTPGQPVDENGLPQDQQE-EEPIPETRIEVEIPKVNTDLGNDLYFVKL 378
+ S S+ E +P T E L ++Q+ ++ RI+V+ + + N
Sbjct: 1353 EEVSESEDEQRPRTRSAKKAE--LEENQRSYKQKKKRRRIKVQEDSSSENKSNS------ 1404
Query: 379 PNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNA 438
+ + + E+E E++E D + + + K+ ++ R E N +KE
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Query: 439 RIVKWSDGSMSLHLGNEVFDVYKA 462
R + ++ EV ++ A
Sbjct: 1465 RRKRIAEREREREKLREVIEIEDA 1488
Score = 53.1 bits (126), Expect = 8e-07
Identities = 141/716 (19%), Positives = 264/716 (36%), Gaps = 97/716 (13%)
Query: 18 RKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+KD + SDS D + SE+ D+ DS E+ E SH S S
Sbjct: 659 KKDKRNSSDSAIDNPKPNKLPKSKQSET-VDQNSDSD-----EMLAILKEVSRMSHSSSS 712
Query: 78 D--------NHSERSDNRSEASE-----RSDHEDNDPSDVDQHSGSEAPNDDEDEGHR-- 122
D NH D +++A + R SD D G A + + R
Sbjct: 713 DTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQT 772
Query: 123 -SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD 181
S+ ++ SE E K+ S K G + ++ ++I N+ D + ++ DE + D
Sbjct: 773 QSESSNYDSELEKEIKSMS---KIG----AARTTKKRIPNTKDFDSSE--DEKHSKKGMD 823
Query: 182 DEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND--DEKQNSDDEEQPQLSD 239
++ +N + D ER+Q E + S E V D + + ++Q S
Sbjct: 824 NQGHKNLKTSQEGSSDDAERKQ---ERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 880
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQDH-KSESARG-----SDSEDEVLRMKRKNAIA 293
+ + S E+ S E + ++ +E+ H K+++ + SD ++ L+ + + +
Sbjct: 881 DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS 940
Query: 294 SDSEADSDT---EVPKDNSGTMDLFGGADDISSGSDGEDKPPT--------PGQPVDENG 342
D + S E K + + S SDG +K P G +NG
Sbjct: 941 EDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNG 1000
Query: 343 LPQDQQEEEPIPETRIEVEIPKVNTDLGN--DLYFVKLPNFLSVEPRPFDPQYYEDEFED 400
+++ + I + + K +L + + K + S E + Y E +
Sbjct: 1001 TTDGEKKSKKIRD-----KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1055
Query: 401 EEMLDEEGRTRLKLKVENTIRWRIRRD---------------EEGNEIKESNARIVKWSD 445
++L + R R +T ++ ++ D E N + N + ++
Sbjct: 1056 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1115
Query: 446 GSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMT 505
S +E K + +++ + K K S+ S
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1175
Query: 506 LSLADRCSKTQKIRI----LPMAGRDPECQRTEMIKKEEERLRASIR--------RESQQ 553
S+ + S QKI+ L ++ CQ + +E L S+ +
Sbjct: 1176 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG-----DEALSKSVPVTVDDDDDDNDPE 1230
Query: 554 RRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEG 613
R+ +K + A+ + ++E EE +N G E + ++ +S+SD
Sbjct: 1231 NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV-NSESDSD 1289
Query: 614 SEEDKA----QRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDD 665
SEE K RLL+ K SD E K K ++ + ++++ V S++ E+ D
Sbjct: 1290 SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1345
Score = 47.0 bits (110), Expect = 6e-05
Identities = 105/599 (17%), Positives = 220/599 (36%), Gaps = 98/599 (16%)
Query: 78 DNHSERSDNRSEASERSDHEDNDPSD-----VDQHSGSEAPNDDEDEGHRSDGGSHHSEA 132
D E S++ + S++ E PSD + E+ +D ++ + H +
Sbjct: 934 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 993
Query: 133 EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
K + D + + D++ +K + SD E++ G D +S+D + E
Sbjct: 994 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG-DSCDSSEDKKSKNGAYGRE 1052
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ + + ++ ++SD E+ ++ NS D+ ++ E+ S +
Sbjct: 1053 KKRCKLLGKSSRKRQDCSSSDTEK---YSMKEDGCNSSDKRLKRIELRERRNLSSKRNTK 1109
Query: 253 ASDEEHRHSDDEEE-QDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
SD EE +D+K + R S + V+ ++K S ++ +S
Sbjct: 1110 EIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1169
Query: 312 MDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGN 371
++ DD +S +G D+Q+ +P+ E + G+
Sbjct: 1170 IE----DDDQNSIGEGSS----------------DEQKIKPVTENLVLSSHTGFCQSSGD 1209
Query: 372 DLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGN 431
+ +P ++V+ +D++ D E R K+ +E I+ + DE+G+
Sbjct: 1210 EALSKSVP--VTVD-------------DDDDDNDPENRIAKKMLLEE-IKANLSSDEDGS 1253
Query: 432 ---EIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTK 488
E +E R K Q + N + ++ ++
Sbjct: 1254 SDDEPEEGKKRTGK----------------------QNEENPGDEEAKNQVNSESDSDSE 1291
Query: 489 LTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIR 548
+ +P K+T+S G E ++T+ KE + ++ R
Sbjct: 1292 ESKKPRYRHRLLRHKLTVS----------------DGESGEEKKTK--PKEHKEVKGRNR 1333
Query: 549 RESQQRRMREKQHQR-GLSASYLEPDRYDEEEEGEESISLAAIKNR---YKGGIREERAR 604
R+ + Q G+S E + DE+ S A ++ YK + R +
Sbjct: 1334 RKVSSEDSEDSDFQESGVSEEVSESE--DEQRPRTRSAKKAELEENQRSYKQKKKRRRIK 1391
Query: 605 IY---SSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 660
+ SS++ SEE++ ++ + ++ +EE E ++ K KK +K + D+
Sbjct: 1392 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450
Score = 44.3 bits (103), Expect = 4e-04
Identities = 120/599 (20%), Positives = 223/599 (37%), Gaps = 102/599 (17%)
Query: 108 SGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEER 167
+ E N+ E + + S + D+ K + KS QS+ + DE
Sbjct: 638 NSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEML 697
Query: 168 AQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEK- 226
A + ++ +S + N L D + Q +++ SD D +K
Sbjct: 698 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 757
Query: 227 -------------------QNSDDEEQPQLSDEEKM---QNSDDERPQASD----EEHRH 260
N D E + ++ K+ + + P D E+ +H
Sbjct: 758 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 817
Query: 261 S-DDEEEQDHKS-ESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGA 318
S + Q HK+ ++++ S+D + +R+ +++ D DT + + D
Sbjct: 818 SKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME----LRDRLPKK 873
Query: 319 DDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKL 378
S+ +DG DK G+ L E + ET+ + + K T K+
Sbjct: 874 QQASASTDGVDK--LSGKEQSFTSL-----EVRKVAETKEKSKHLKTKT-------CKKV 919
Query: 379 PNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNA 438
+ LS F + DE +++ + T K K + + I+ +++ ES+
Sbjct: 920 QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQ----YESS- 974
Query: 439 RIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDS 498
SDG+ L E+ K Q I+ GT G+ K D
Sbjct: 975 -----SDGTEKLPEREEICHFPKGIKQ-------IKNGT-TDGEKKSK-------KIRDK 1014
Query: 499 ATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMRE 558
+ +K LS D K+ G+ C +E +++ + RE ++ ++
Sbjct: 1015 TSKKKDELS--DYAEKS--------TGKGDSCDSSE----DKKSKNGAYGREKKRCKLLG 1060
Query: 559 KQHQRGLSASYLEPDRYDEEEEGEES-------ISLAAIKN-RYKGGIREERARIYSSDS 610
K ++ S + ++Y +E+G S I L +N K +E ++ SSD+
Sbjct: 1061 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1120
Query: 611 DEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVI---SDEEEEDDD 666
+E SE++K K K+ TS ++ K K + + + K K+ I S + EDDD
Sbjct: 1121 EESSEDNK-----KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDD 1174
Score = 34.3 bits (77), Expect = 0.38
Identities = 21/125 (16%), Positives = 54/125 (43%), Gaps = 3/125 (2%)
Query: 542 RLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREE 601
+L S ++++ + K+H+ + + D E+ + + + E+
Sbjct: 1306 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQE---SGVSEEVSESEDEQ 1362
Query: 602 RARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEE 661
R R S+ E E ++ + K ++ +E S + ++++ K+ ++ +EE
Sbjct: 1363 RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1422
Query: 662 EEDDD 666
EE++D
Sbjct: 1423 EEEED 1427
Score = 33.5 bits (75), Expect = 0.65
Identities = 24/95 (25%), Positives = 35/95 (36%), Gaps = 13/95 (13%)
Query: 154 SDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEK---- 209
S +E + S A + DK+ S + M EE S+ + S K
Sbjct: 25 SSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPS 84
Query: 210 -----ANSDDERPVASDNDDEKQNSDDEEQPQLSD 239
SDDE+P+ DDE N D + +D
Sbjct: 85 IVTKYVESDDEKPL----DDETVNEDASNENSEND 115
Score = 30.0 bits (66), Expect = 7.2
Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 20/117 (17%)
Query: 85 DNRSEASERSDHEDNDP-----SDVDQHSGSEAPND----DEDEGHRSDGGSHHSEAEGS 135
D + +SE S+ + P + D+ SGS + +D ++EG S S S + S
Sbjct: 20 DFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRS 79
Query: 136 EKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
++ S K+ D DDE + E NS++D MQ+ E+
Sbjct: 80 KRKPSIVTKYVESDDEKPLDDETVNEDASNE-----------NSENDITMQSLPKED 125
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 73.6 bits (179), Expect = 6e-13
Identities = 73/385 (18%), Positives = 154/385 (40%), Gaps = 71/385 (18%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQ------------------DERGDSGQ 55
+ +RK +D S S SD E+ S GS +Q GD
Sbjct: 1191 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1250
Query: 56 PSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---EA 112
+ + DD +D+ + + + +S+ D++P + + +G E
Sbjct: 1251 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1310
Query: 113 PNDDEDEGH-RSDGGSHHSEAEGSEKAHS--------DDEKWGREDKSDQSDDEKIQNSD 163
P D+E + S+ S E++ H D + G E K+ + ++++ +
Sbjct: 1311 PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN 1370
Query: 164 DEE-RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDER----PV 218
+ ++ S++ Q S E++ ++DE+RP+ ++ +L E +++ ++ V
Sbjct: 1371 RRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKV 1430
Query: 219 ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSD 278
D+ E +++ +EE+ + +EE+ +EE ++E+E D +G
Sbjct: 1431 QEDSSSENKSNSEEEEEEKEEEEE------------EEEEEEEEEEDENDDSKSPGKGRK 1478
Query: 279 S-----EDEVLRMKRKNAIASDSE-----ADSDTEVPKDNSGTMDLFGGADDISSGSDGE 328
+D+ LR + +NA+ + E A+ + E K + + E
Sbjct: 1479 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK--------------LREVIEIE 1524
Query: 329 DKPPTPGQPVDENGLPQDQQEEEPI 353
D PT + L +D++ +EP+
Sbjct: 1525 DASPTKCPITTKLVLDEDEETKEPL 1549
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/231 (19%), Positives = 103/231 (44%), Gaps = 6/231 (2%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQD-ERGDSGQPSNKELFG 63
ED D E +++ ++ D+E N SESD D E + ++ L
Sbjct: 1288 EDGSSDDEPEEGKKRTGKQNEENPGDEE----AKNQVNSESDSDSEESKKPRYRHRLLRH 1343
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
+ +G S E + + + ED++ SD + SE ++ EDE
Sbjct: 1344 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDE 183
+ +E E +++++ +K R + S E NS++EE + +E++ + +++E
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463
Query: 184 KMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
+ +N DD + P + +++ +++K ++ + + + + K+ ++ E +
Sbjct: 1464 EDEN-DDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1513
Score = 60.5 bits (145), Expect = 5e-09
Identities = 159/796 (19%), Positives = 288/796 (36%), Gaps = 175/796 (21%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSE-SDQDERGDSGQPSNKEL 61
D++ G D + +RK S SGSD D+ + +A S S + Q E + KE+
Sbjct: 766 DLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEI 825
Query: 62 FG--------------------DDSEDEGAS--------------HHSGSDNHSERSDNR 87
D SEDE S GS + +ER R
Sbjct: 826 KSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQER 885
Query: 88 SEASERSDHEDNDPSDVD--------QHSGSEAPNDDEDEGHRSDGGS--HHSEAEGSEK 137
S D D + ++ Q + + D+ G S AE EK
Sbjct: 886 ETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEK 945
Query: 138 AH--------------SD-DEKWGREDKSDQS--DDEKIQNSDDEERAQGSD-------- 172
+ SD EK+ ++D+SD++ DD+K EE+ + SD
Sbjct: 946 SKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKM 1005
Query: 173 EDKLQNSDD-------------------------------DEKMQNTDDEERPQLSDDER 201
E + ++S D +K+++ +++ +LSD
Sbjct: 1006 EQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAE 1065
Query: 202 QQLSEEEKANSDDER--------------PVASDNDDEKQNSDDEEQPQLSDEEKMQNSD 247
+ + + +S +++ + + ++Q+ + + S +E NS
Sbjct: 1066 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1125
Query: 248 DERPQASD-EEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPK 306
D+R + + E R+ + + SD+E+ K+K S + + K
Sbjct: 1126 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1185
Query: 307 DNSGTMDLFGGADDI--SSGSDGEDKPPTPGQPVDENGLPQ---DQQEEEPIPETRIEVE 361
NS DI SS SD ED D+N + + D+Q+ +P+ E +
Sbjct: 1186 RNSLRTSTKRKQADITSSSSSDIEDD--------DQNSIGEGSSDEQKIKPVTENLVLSS 1237
Query: 362 IPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIR 421
G++ +P ++V+ +D++ D E R K+ +E I+
Sbjct: 1238 HTGFCQSSGDEALSKSVP--VTVD-------------DDDDDNDPENRIAKKMLLEE-IK 1281
Query: 422 WRIRRDEEG---NEIKESNARIVKWS-----DGSMSLHLGNEVFDVYKAPLQGDHNHLFI 473
+ DE+G +E +E R K + D + +E + + + H +
Sbjct: 1282 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1341
Query: 474 RQG-TGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILP--MAGRDPEC 530
R T G++ + K + H +R+ S S Q+ + D +
Sbjct: 1342 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1401
Query: 531 QRTEMIKKEE-ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAA 589
RT KK E E + S +++ ++RR++ ++ + S E + ++EEE EE
Sbjct: 1402 PRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE--- 1458
Query: 590 IKNRYKGGIREERARIYSSDS-DEGSEEDKAQRLLKAKKLTSD-----EEGEPSGKRKAE 643
EE + DS G K +++LK KL ++ +E E KR AE
Sbjct: 1459 ---------EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAE 1509
Query: 644 DDDKANKKHKKYVISD 659
+ + K + I D
Sbjct: 1510 REREREKLREVIEIED 1525
Score = 59.3 bits (142), Expect = 1e-08
Identities = 99/504 (19%), Positives = 193/504 (38%), Gaps = 82/504 (16%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNK-ELFGDDSEDEGA 71
D +++KD S D +++ G + SE + + G G+ + +L G S
Sbjct: 1051 DKTSKKKDELS----DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQD 1106
Query: 72 SHHSGSDNHSERSDN---------RSEASERSD--HEDNDPSDVDQHSGSEAPNDDEDEG 120
S ++ +S + D R E ER + + N S S+A ED
Sbjct: 1107 CSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNK 1166
Query: 121 HRSDGGSHHSEAE-GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQG---SDEDKL 176
+ S +A EK + + ++D + DD++ + G SDE K+
Sbjct: 1167 KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1226
Query: 177 Q---------------NSDDDEKMQNT-------DDEERPQLSDDERQQLSEEEKANSDD 214
+ S DE + + DD++ + ++ L EE KAN
Sbjct: 1227 KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSS 1286
Query: 215 ERPVASDNDDE-------KQNS----DDEEQPQLSDEEKMQNSDDERPQASDEEHRH--- 260
+ +SD++ E KQN D+E + Q++ E + + ++P+ RH
Sbjct: 1287 DEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLT 1346
Query: 261 -SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGAD 319
SD E ++ K++ E + ++ + + ++S+ DSD + G
Sbjct: 1347 VSDGESGEEKKTKP-----KEHKEVKGRNRRKVSSEDSEDSDFQE-----------SGVS 1390
Query: 320 DISSGSDGEDKPPTPGQPVDENGLPQDQQE-EEPIPETRIEVEIPKVNTDLGNDLYFVKL 378
+ S S+ E +P T E L ++Q+ ++ RI+V+ + + N
Sbjct: 1391 EEVSESEDEQRPRTRSAKKAE--LEENQRSYKQKKKRRRIKVQEDSSSENKSNS------ 1442
Query: 379 PNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNA 438
+ + + E+E E++E D + + + K+ ++ R E N +KE
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Query: 439 RIVKWSDGSMSLHLGNEVFDVYKA 462
R + ++ EV ++ A
Sbjct: 1503 RRKRIAEREREREKLREVIEIEDA 1526
Score = 53.1 bits (126), Expect = 8e-07
Identities = 141/716 (19%), Positives = 264/716 (36%), Gaps = 97/716 (13%)
Query: 18 RKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+KD + SDS D + SE+ D+ DS E+ E SH S S
Sbjct: 697 KKDKRNSSDSAIDNPKPNKLPKSKQSET-VDQNSDSD-----EMLAILKEVSRMSHSSSS 750
Query: 78 D--------NHSERSDNRSEASE-----RSDHEDNDPSDVDQHSGSEAPNDDEDEGHR-- 122
D NH D +++A + R SD D G A + + R
Sbjct: 751 DTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQT 810
Query: 123 -SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD 181
S+ ++ SE E K+ S K G + ++ ++I N+ D + ++ DE + D
Sbjct: 811 QSESSNYDSELEKEIKSMS---KIG----AARTTKKRIPNTKDFDSSE--DEKHSKKGMD 861
Query: 182 DEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND--DEKQNSDDEEQPQLSD 239
++ +N + D ER+Q E + S E V D + + ++Q S
Sbjct: 862 NQGHKNLKTSQEGSSDDAERKQ---ERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 918
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQDH-KSESARG-----SDSEDEVLRMKRKNAIA 293
+ + S E+ S E + ++ +E+ H K+++ + SD ++ L+ + + +
Sbjct: 919 DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS 978
Query: 294 SDSEADSDT---EVPKDNSGTMDLFGGADDISSGSDGEDKPPT--------PGQPVDENG 342
D + S E K + + S SDG +K P G +NG
Sbjct: 979 EDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNG 1038
Query: 343 LPQDQQEEEPIPETRIEVEIPKVNTDLGN--DLYFVKLPNFLSVEPRPFDPQYYEDEFED 400
+++ + I + + K +L + + K + S E + Y E +
Sbjct: 1039 TTDGEKKSKKIRD-----KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKR 1093
Query: 401 EEMLDEEGRTRLKLKVENTIRWRIRRD---------------EEGNEIKESNARIVKWSD 445
++L + R R +T ++ ++ D E N + N + ++
Sbjct: 1094 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1153
Query: 446 GSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMT 505
S +E K + +++ + K K S+ S
Sbjct: 1154 SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1213
Query: 506 LSLADRCSKTQKIRI----LPMAGRDPECQRTEMIKKEEERLRASIR--------RESQQ 553
S+ + S QKI+ L ++ CQ + +E L S+ +
Sbjct: 1214 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG-----DEALSKSVPVTVDDDDDDNDPE 1268
Query: 554 RRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEG 613
R+ +K + A+ + ++E EE +N G E + ++ +S+SD
Sbjct: 1269 NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV-NSESDSD 1327
Query: 614 SEEDKA----QRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDD 665
SEE K RLL+ K SD E K K ++ + ++++ V S++ E+ D
Sbjct: 1328 SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
Score = 47.0 bits (110), Expect = 6e-05
Identities = 105/599 (17%), Positives = 220/599 (36%), Gaps = 98/599 (16%)
Query: 78 DNHSERSDNRSEASERSDHEDNDPSD-----VDQHSGSEAPNDDEDEGHRSDGGSHHSEA 132
D E S++ + S++ E PSD + E+ +D ++ + H +
Sbjct: 972 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 1031
Query: 133 EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
K + D + + D++ +K + SD E++ G D +S+D + E
Sbjct: 1032 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG-DSCDSSEDKKSKNGAYGRE 1090
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ + + ++ ++SD E+ ++ NS D+ ++ E+ S +
Sbjct: 1091 KKRCKLLGKSSRKRQDCSSSDTEK---YSMKEDGCNSSDKRLKRIELRERRNLSSKRNTK 1147
Query: 253 ASDEEHRHSDDEEE-QDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
SD EE +D+K + R S + V+ ++K S ++ +S
Sbjct: 1148 EIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1207
Query: 312 MDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGN 371
++ DD +S +G D+Q+ +P+ E + G+
Sbjct: 1208 IE----DDDQNSIGEGSS----------------DEQKIKPVTENLVLSSHTGFCQSSGD 1247
Query: 372 DLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGN 431
+ +P ++V+ +D++ D E R K+ +E I+ + DE+G+
Sbjct: 1248 EALSKSVP--VTVD-------------DDDDDNDPENRIAKKMLLEE-IKANLSSDEDGS 1291
Query: 432 ---EIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTK 488
E +E R K Q + N + ++ ++
Sbjct: 1292 SDDEPEEGKKRTGK----------------------QNEENPGDEEAKNQVNSESDSDSE 1329
Query: 489 LTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIR 548
+ +P K+T+S G E ++T+ KE + ++ R
Sbjct: 1330 ESKKPRYRHRLLRHKLTVS----------------DGESGEEKKTK--PKEHKEVKGRNR 1371
Query: 549 RESQQRRMREKQHQR-GLSASYLEPDRYDEEEEGEESISLAAIKNR---YKGGIREERAR 604
R+ + Q G+S E + DE+ S A ++ YK + R +
Sbjct: 1372 RKVSSEDSEDSDFQESGVSEEVSESE--DEQRPRTRSAKKAELEENQRSYKQKKKRRRIK 1429
Query: 605 IY---SSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 660
+ SS++ SEE++ ++ + ++ +EE E ++ K KK +K + D+
Sbjct: 1430 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488
Score = 44.3 bits (103), Expect = 4e-04
Identities = 120/599 (20%), Positives = 223/599 (37%), Gaps = 102/599 (17%)
Query: 108 SGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEER 167
+ E N+ E + + S + D+ K + KS QS+ + DE
Sbjct: 676 NSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEML 735
Query: 168 AQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEK- 226
A + ++ +S + N L D + Q +++ SD D +K
Sbjct: 736 AILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG 795
Query: 227 -------------------QNSDDEEQPQLSDEEKM---QNSDDERPQASD----EEHRH 260
N D E + ++ K+ + + P D E+ +H
Sbjct: 796 KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH 855
Query: 261 S-DDEEEQDHKS-ESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGA 318
S + Q HK+ ++++ S+D + +R+ +++ D DT + + D
Sbjct: 856 SKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME----LRDRLPKK 911
Query: 319 DDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKL 378
S+ +DG DK G+ L E + ET+ + + K T K+
Sbjct: 912 QQASASTDGVDK--LSGKEQSFTSL-----EVRKVAETKEKSKHLKTKT-------CKKV 957
Query: 379 PNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNA 438
+ LS F + DE +++ + T K K + + I+ +++ ES+
Sbjct: 958 QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQ----YESS- 1012
Query: 439 RIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDS 498
SDG+ L E+ K Q I+ GT G+ K D
Sbjct: 1013 -----SDGTEKLPEREEICHFPKGIKQ-------IKNGT-TDGEKKSK-------KIRDK 1052
Query: 499 ATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMRE 558
+ +K LS D K+ G+ C +E +++ + RE ++ ++
Sbjct: 1053 TSKKKDELS--DYAEKS--------TGKGDSCDSSE----DKKSKNGAYGREKKRCKLLG 1098
Query: 559 KQHQRGLSASYLEPDRYDEEEEGEES-------ISLAAIKN-RYKGGIREERARIYSSDS 610
K ++ S + ++Y +E+G S I L +N K +E ++ SSD+
Sbjct: 1099 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1158
Query: 611 DEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVI---SDEEEEDDD 666
+E SE++K K K+ TS ++ K K + + + K K+ I S + EDDD
Sbjct: 1159 EESSEDNK-----KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDD 1212
Score = 34.3 bits (77), Expect = 0.38
Identities = 21/125 (16%), Positives = 54/125 (43%), Gaps = 3/125 (2%)
Query: 542 RLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREE 601
+L S ++++ + K+H+ + + D E+ + + + E+
Sbjct: 1344 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQE---SGVSEEVSESEDEQ 1400
Query: 602 RARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEE 661
R R S+ E E ++ + K ++ +E S + ++++ K+ ++ +EE
Sbjct: 1401 RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1460
Query: 662 EEDDD 666
EE++D
Sbjct: 1461 EEEED 1465
Score = 33.5 bits (75), Expect = 0.65
Identities = 24/95 (25%), Positives = 35/95 (36%), Gaps = 13/95 (13%)
Query: 154 SDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEK---- 209
S +E + S A + DK+ S + M EE S+ + S K
Sbjct: 25 SSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPS 84
Query: 210 -----ANSDDERPVASDNDDEKQNSDDEEQPQLSD 239
SDDE+P+ DDE N D + +D
Sbjct: 85 IVTKYVESDDEKPL----DDETVNEDASNENSEND 115
Score = 33.1 bits (74), Expect = 0.85
Identities = 28/149 (18%), Positives = 55/149 (36%), Gaps = 4/149 (2%)
Query: 74 HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAE 133
HS ++ S R ++ +D S+ D S+ E +S G S
Sbjct: 24 HSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKP 83
Query: 134 G--SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDE 191
++ SDDEK D ++D +NS+++ Q + + + ++ DD
Sbjct: 84 SIVTKYVESDDEK--PLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDF 141
Query: 192 ERPQLSDDERQQLSEEEKANSDDERPVAS 220
+ P+ + + +K D + S
Sbjct: 142 KGPEFRSRSKMKTENLKKRGEDGLHGIVS 170
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 73.2 bits (178), Expect = 7e-13
Identities = 122/642 (19%), Positives = 222/642 (34%), Gaps = 113/642 (17%)
Query: 2 ADMEDLFGSDADSEAERKDSD--------SGSDSDSDQENAAS--GSNASGSESDQDERG 51
A++ S D E KD S D + + E+ + G G S + G
Sbjct: 55 AELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVG 114
Query: 52 DSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEA-SERS-DHEDNDPSDV---DQ 106
D G S +E+F + GS++ + +++R S RS H+D D +V +
Sbjct: 115 DEGV-SGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEH 173
Query: 107 HS-----GSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQN 161
H G + ++DEG + E +E H G + D+ + +
Sbjct: 174 HHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHH 233
Query: 162 SDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASD 221
R QG +ED DD+ + DD++ +S + R Q + +++ V+
Sbjct: 234 HGPSHRHQGHEED------DDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS-- 285
Query: 222 NDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSED 281
+ + D S EE + DD + + HRH QDH+ E E
Sbjct: 286 ---DGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRH------QDHRKEEVEAVSGEH 336
Query: 282 EVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDEN 341
++ D E D D + + G + +
Sbjct: 337 HHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHV-------------------------HH 371
Query: 342 GLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDE 401
GL +++EEE I V+ ++++ +P + E++F+DE
Sbjct: 372 GLVDEEEEEEEIT---------------------VQFGHYVA-SHQPRGHKSDEEDFQDE 409
Query: 402 EMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYK 461
K +V + R+ R+E+ +E +A + + H E +
Sbjct: 410 ----------YKTEVPHHHHHRVPREED----EEVSAELGHQAPSHRQSHQDEETGHGQR 455
Query: 462 APLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSL--ADRCSKTQKIR 519
++ +H G V K + R ++ ++ D S Q +
Sbjct: 456 GSIKEMSHH--------PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEK 507
Query: 520 ILPMAGRDPECQRTEM----IKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRY 575
RD E + E + +E + E ++ E++ +R + L PD
Sbjct: 508 GTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHS 567
Query: 576 DEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEED 617
+EEEE EE + + + R + S+E S ED
Sbjct: 568 EEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGED 609
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/370 (20%), Positives = 134/370 (36%), Gaps = 77/370 (20%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQ----PSNKELFG- 63
G + D + + D D D D E G ++DE G PS++
Sbjct: 242 GHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHE 301
Query: 64 -DDSEDEGASHHSGSDNHSERSDNRSEAS-----------------ERSDHEDNDPSDVD 105
DD++D+ S G H + + E R + ED D S
Sbjct: 302 EDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTER 361
Query: 106 QHSGSEAPN----DDEDEGHRSDGGSHHSEAEGSEKAH-SDDEKWGREDKSD-------- 152
H G + + D+E+E H A + H SD+E + E K++
Sbjct: 362 WHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHR 421
Query: 153 --QSDDEKI------------QNSDDEERAQGS------------------DEDKLQNSD 180
+ +DE++ Q+ DEE G D L+ D
Sbjct: 422 VPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDD 481
Query: 181 DDEKMQNTDDEERPQLSDDERQQ--------LSEEEKANSDDERPVASDNDDEKQNSDDE 232
+E+ + +D + D+ +Q ++E ++E S N +E++ D E
Sbjct: 482 SEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKE 541
Query: 233 EQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
E+ + DEE+ + + S + H ++EEE+ + + R + + + R +
Sbjct: 542 EEEEEEDEERREERAEVGAPLSPD-HSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA 600
Query: 293 ASDSEADSDT 302
+S+ E+ DT
Sbjct: 601 SSEEESGEDT 610
Score = 59.7 bits (143), Expect = 8e-09
Identities = 61/236 (25%), Positives = 98/236 (41%), Gaps = 40/236 (16%)
Query: 54 GQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAP 113
G S++E F D+ + E HH +H + E S H+ PS H
Sbjct: 398 GHKSDEEDFQDEYKTEVPHHH----HHRVPREEDEEVSAELGHQA--PSHRQSHQ----- 446
Query: 114 NDDEDEGHRSDGG----SHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQ 169
DE+ GH G SHH K S K E++ ++ +D DDE Q
Sbjct: 447 --DEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQ 504
Query: 170 GSDEDKLQNSDDDEKMQNTDDEERPQLS---DDERQQLSEEEKANSDDER---------P 217
G + D +++ D+EE LS ++E ++ EEE+ D+ER P
Sbjct: 505 GEKGTHHGSRDQEDE---EDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAP 561
Query: 218 VASDNDDEKQNSDDEEQPQLSDEEK---MQNSDDERPQA--SDEEHRHSDDEEEQD 268
++ D+ +E+ ++EE+ DE + + N D R +A + E +D QD
Sbjct: 562 LSPDHSEEE---EEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQD 614
Score = 49.3 bits (116), Expect = 1e-05
Identities = 109/616 (17%), Positives = 208/616 (33%), Gaps = 82/616 (13%)
Query: 86 NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSD-DEK 144
NR+ ++ + + +++ H S + DE++ ++ G H EK D ++
Sbjct: 39 NRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE 98
Query: 145 WGREDKSDQSDDEKIQN---SDDEERAQGSDEDKLQNSDDDEKMQNTDDEER--PQLSDD 199
+G +S D K+ + S +E A+ + + E +++ + P
Sbjct: 99 YGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSH 158
Query: 200 ERQQLSEEEKANSDDERPV---------ASDNDDEKQNSDDEEQPQLSDEEKMQ------ 244
Q E+E +S+ + D++ E++ ++EE+ + S E Q
Sbjct: 159 SHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRG 218
Query: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
+ +E SD H H Q H+ + D +D+ D + D D +
Sbjct: 219 HGSEEDEDVSDGHHHHGPSHRHQGHEEDD---DDDDDD-----------DDDDDDDDVSI 264
Query: 305 PKDNSGTMDLFGGADDISSGSDGED--KPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362
+ G ++ SDG P + +E+ D E + +
Sbjct: 265 EYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDH 324
Query: 363 PKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRW 422
K + + + +P+ Q + DE EDE++ E R ++
Sbjct: 325 RKEEVEAVSGEHHHHVPDHRH--------QGHRDEEEDEDVSTE----RWHQGPQHVHHG 372
Query: 423 RIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQ 482
+ +EE EI V + D YK + H+H R+
Sbjct: 373 LVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSA 432
Query: 483 AVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRI------LPMAGRDPECQRTEMI 536
+ + R D T S+ + + L + E ++ E
Sbjct: 433 ELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDP 492
Query: 537 KKEEERLRASIRRES-------QQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAA 589
EE +S + E Q +++ GLS + E + D+EEE EE
Sbjct: 493 GSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEER- 551
Query: 590 IKNRYKGGIREERARI----------YSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGK 639
REERA + + +EG EED+ + + L EE +
Sbjct: 552 ---------REERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASS 602
Query: 640 RKAEDDDKANKKHKKY 655
+ +D + ++Y
Sbjct: 603 EEESGEDTGPQDAQEY 618
Score = 39.7 bits (91), Expect = 0.009
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 15/144 (10%)
Query: 13 DSEAER-KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
DSE E+ K+ D GS + D+ + DQ++ D + L ++ E+E
Sbjct: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
Query: 72 SHHSGSDNHSERSDNRSE---------ASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHR 122
+ ER + R+E + E + E+ D + + P D +E
Sbjct: 541 EEEE-EEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEA-- 597
Query: 123 SDGGSHHSEAEGSEKAHSDDEKWG 146
GG+ E G + D +++G
Sbjct: 598 --GGASSEEESGEDTGPQDAQEYG 619
Score = 35.0 bits (79), Expect = 0.22
Identities = 32/161 (19%), Positives = 58/161 (36%), Gaps = 19/161 (11%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
ED + D E+ + DQE+ G +Q+E + + +E +
Sbjct: 490 EDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDE 549
Query: 65 DSEDEGASHHSG-SDNHSERSDNRSEASERSD------------HEDNDPSDVDQHSGSE 111
+ +E A + S +HSE + E E + E+ + ++ SG +
Sbjct: 550 ERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGED 609
Query: 112 -APNDDEDEGHRSDGG-----SHHSEAEGSEKAHSDDEKWG 146
P D ++ G+ G S + E H D+E G
Sbjct: 610 TGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMG 650
Score = 34.3 bits (77), Expect = 0.38
Identities = 29/122 (23%), Positives = 54/122 (44%), Gaps = 7/122 (5%)
Query: 547 IRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGG-IREERARI 605
+ RE + E HQ + S+ + + +E G+ S+ + + G + ++R+ +
Sbjct: 422 VPREEDEEVSAELGHQ---APSHRQSHQDEETGHGQRG-SIKEMSHHPPGHTVVKDRSHL 477
Query: 606 YSSDSDEGSE--EDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEE 663
DS+E E ED + E+G G R ED++ + H + +EEEE
Sbjct: 478 RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEE 537
Query: 664 DD 665
+D
Sbjct: 538 ED 539
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/259 (20%), Positives = 106/259 (40%), Gaps = 6/259 (2%)
Query: 35 ASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASER- 93
A G + + + ER + + +E H D H ER +R + ER
Sbjct: 49 ADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQ 108
Query: 94 SDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQ 153
+D E + + +++ E + E EG R + E + ++ E+ + D+ Q
Sbjct: 109 TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168
Query: 154 SDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSE---EEKA 210
E+ N E + + +++ + EK T+D + + ER++ +E E K
Sbjct: 169 RQTER--NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKR 226
Query: 211 NSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHK 270
+D ER + E++ + E+ + E+ + + ER + D + R + E + D K
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK 286
Query: 271 SESARGSDSEDEVLRMKRK 289
+ D E E R +++
Sbjct: 287 RQRRTERDRETERKRERQR 305
Score = 70.5 bits (171), Expect = 5e-12
Identities = 62/307 (20%), Positives = 117/307 (38%), Gaps = 15/307 (4%)
Query: 13 DSEAER-KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
D E +R ++ + + ++E G ++D + + + KE +
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHS--GSEAPNDDEDEGHRSDGGSHH 129
ER NR E ER + + D+HS G E + E E
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTD 229
Query: 130 SEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD---DEKMQ 186
E + K + EK +++ + + E+ + ER + D D+ Q + D K Q
Sbjct: 230 RERDRQRKTEREREKQAERERASERETER-DKERERERDRDRDRDRRQKERERQTDRKRQ 288
Query: 187 NTDDEERPQLSDDERQQLSEEEKANS---DDERPVASDNDDEKQNSDDEEQPQLSDEEKM 243
+ +R ERQ+ E E+ + + ER + + +++ D E+ + ++
Sbjct: 289 RRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQ 348
Query: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
D ER + + E R E E++ + E R S E R +R+ D + + + +
Sbjct: 349 TEMDRERNRQTGREGRR-QAERERERERERDRQSARE----REERERDRDRDRQKERERQ 403
Query: 304 VPKDNSG 310
KD G
Sbjct: 404 TEKDRDG 410
Score = 57.0 bits (136), Expect = 5e-08
Identities = 55/279 (19%), Positives = 106/279 (37%), Gaps = 12/279 (4%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
E E K D S+ ++E + + D D + + +E + +
Sbjct: 196 EKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERE 255
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
+ D ER +R +R E +D + +E D E E R E E
Sbjct: 256 TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE--RDRETERKRERQRERERERER 313
Query: 135 SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERP 194
+ K + E+ ++ Q + E+ + + E + K Q D E+ + T E R
Sbjct: 314 NRKRERERER--ERERERQRETERDREKERERKR------KRQTEMDRERNRQTGREGRR 365
Query: 195 QLSDD-ERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQA 253
Q + ER++ + + A +ER D D +K+ E+ + E + + E+ +
Sbjct: 366 QAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Query: 254 SDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
S E R E E+ E R ++ + R ++++ +
Sbjct: 426 S-ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 56.6 bits (135), Expect = 7e-08
Identities = 44/248 (17%), Positives = 97/248 (39%), Gaps = 9/248 (3%)
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSE 131
S S R +A + +D +D + + + E E R +
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 132 AEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTD-- 189
H + ++ +++ Q+D E+ + + E Q E + + + + + TD
Sbjct: 87 RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ 146
Query: 190 -DEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD 248
+ ER + ++ ER++ ++ E+ + + E++ + E + + EK ++D
Sbjct: 147 RERERQRDAEKERERQTDRERQRQTERN---RQKEREREKNRQERRERERQREKENKTED 203
Query: 249 ERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNA---IASDSEADSDTEVP 305
+ E R + E E + K ++ R D + + R + K A AS+ E + D E
Sbjct: 204 RHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERE 263
Query: 306 KDNSGTMD 313
++ D
Sbjct: 264 RERDRDRD 271
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/269 (18%), Positives = 103/269 (38%), Gaps = 22/269 (8%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
E ER+ D E +E++ + + + + +++ + ++ A
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
S+ +ER R ER D D ++ ++ E R
Sbjct: 250 RASERETERDKERER--ERDRDRDRDRRQKERERQTDRKRQRRTERDRE----------- 296
Query: 135 SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERP 194
+E+ + RE + ++ + + + + ER + ++ D+ + + K Q D ER
Sbjct: 297 TERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN 356
Query: 195 QLSDDE-RQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQA 253
+ + E R+Q E + + +R A + ++ +++ D + Q E + Q D Q
Sbjct: 357 RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQK----ERERQTEKDRDGQR 412
Query: 254 SDEEHRHSDDEEEQDHKSESARGSDSEDE 282
E+ R E E+D +SE R E E
Sbjct: 413 ETEKQR----EREKDRESERGRERGRERE 437
Score = 53.9 bits (128), Expect = 5e-07
Identities = 56/312 (17%), Positives = 123/312 (39%), Gaps = 31/312 (9%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
DA+ E ER+ +D + ++ + E ++ ER + + KE +D E
Sbjct: 154 DAEKERERQ-----TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSER 208
Query: 71 A-----SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
+ ++ +R +R +R + + ++ SE + + E R
Sbjct: 209 GRERERERETETETERKRQTDRERDRQRKTERERE-KQAERERASERETERDKERERERD 267
Query: 126 GSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
+ E+ D K R + D+ + K + + ER + + + + + + +
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSD------ 239
+ + ER + + ER++ + E D ER + + +Q + E+ + D
Sbjct: 328 ERQRETERDREKERERKRKRQTEM---DRERNRQTGREGRRQAERERERERERDRQSARE 384
Query: 240 -EEKMQNSDDERPQASDEE-------HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNA 291
EE+ ++ D +R + + + R ++ + E++ ES RG + E R K+K
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRE--REKQKGR 442
Query: 292 IASDSEADSDTE 303
D E +D +
Sbjct: 443 -ERDRERQTDRQ 453
Score = 37.4 bits (85), Expect = 0.045
Identities = 85/441 (19%), Positives = 160/441 (36%), Gaps = 46/441 (10%)
Query: 220 SDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDD---EEEQDHKSESARG 276
+D DD ++N E + + + + +D +R + +++ D E ++D + E R
Sbjct: 49 ADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQ 108
Query: 277 SDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQ 336
+D E + R K +N E + +TE G G D+ T GQ
Sbjct: 109 TDRERDRQREKERNR---QKERERETE------------------REGERGRDRQ-TDGQ 146
Query: 337 PVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYED 396
E +++ E R + T+ + N R + E
Sbjct: 147 RERERQRDAEKERERQTDRER------QRQTERNRQKEREREKNRQERRERE---RQREK 197
Query: 397 EFEDEEMLDEEGRTRLKLKVENTIRWRIRR-DEEGNEIKESNARIVKWSDGSMSLHLGNE 455
E + E+ E GR R + + T R R+ D E + +++ K ++ + E
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 456 VFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLA-DRCSK 514
+ D + RQ + + + T R T+ R+ +R K
Sbjct: 258 RDKERERERDRDRDR-DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRK 316
Query: 515 TQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSA-SYLEPD 573
++ R R+ E QR +E+ER R +R+ Q RE+ Q G E +
Sbjct: 317 RERER---ERERERERQRETERDREKERER---KRKRQTEMDRERNRQTGREGRRQAERE 370
Query: 574 RYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEE 633
R E E +S + R + R++ + +G E + QR + +K E
Sbjct: 371 RERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQR--EREKDRESER 428
Query: 634 GEPSGKRKAEDDDKANKKHKK 654
G G+ + + + + ++
Sbjct: 429 GRERGREREKQKGRERDRERQ 449
Score = 35.0 bits (79), Expect = 0.22
Identities = 28/140 (20%), Positives = 59/140 (42%), Gaps = 5/140 (3%)
Query: 526 RDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESI 585
RD E +R ++E ER R R ++ R RE++ +R + E + +
Sbjct: 293 RDRETERKRERQRERERER---ERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Query: 586 SLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDD 645
+ +NR G RE R + E + ++ R + ++ D + + +R+ E D
Sbjct: 350 EMDRERNRQTG--REGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKD 407
Query: 646 DKANKKHKKYVISDEEEEDD 665
++ +K +++ E +
Sbjct: 408 RDGQRETEKQREREKDRESE 427
Score = 32.7 bits (73), Expect = 1.1
Identities = 33/148 (22%), Positives = 58/148 (39%), Gaps = 10/148 (6%)
Query: 526 RDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESI 585
R+ E R E ++E +R + + + R RE++ +R + D E + +
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238
Query: 586 SLAAIK--NRYKGGIRE-------ERARIYSSDSDEGSEEDKAQRLLKAKKLTS-DEEGE 635
K R + RE ER R D D +E + Q K ++ T D E E
Sbjct: 239 EREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETE 298
Query: 636 PSGKRKAEDDDKANKKHKKYVISDEEEE 663
+R+ E + + + K+ + E E
Sbjct: 299 RKRERQRERERERERNRKRERERERERE 326
Score = 32.0 bits (71), Expect = 1.9
Identities = 26/138 (18%), Positives = 59/138 (42%), Gaps = 5/138 (3%)
Query: 526 RDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESI 585
R E +R + E ER +R++ + R R+++ +R + E E ++
Sbjct: 208 RGRERERERETETETER-----KRQTDRERDRQRKTEREREKQAERERASERETERDKER 262
Query: 586 SLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDD 645
++R + ++ER R +E D+ + ++ + E E + KR+ E +
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322
Query: 646 DKANKKHKKYVISDEEEE 663
+ ++ ++ D E+E
Sbjct: 323 RERERERQRETERDREKE 340
Score = 30.0 bits (66), Expect = 7.2
Identities = 28/143 (19%), Positives = 59/143 (41%), Gaps = 7/143 (4%)
Query: 526 RDPECQRTEMIKKEEERLR---ASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGE 582
R+ + +R ++E ER R +RE +++R EK+ +R + ++E E
Sbjct: 121 RNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERE 180
Query: 583 ESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKA 642
+ + R + +E + S+ E ++ +K +D E + K +
Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER 240
Query: 643 EDDDKANKKHKKYVISDEEEEDD 665
E + +A ++ S+ E E D
Sbjct: 241 EREKQAERER----ASERETERD 259
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 70.9 bits (172), Expect = 4e-12
Identities = 71/298 (23%), Positives = 133/298 (44%), Gaps = 37/298 (12%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE--- 69
DS+ E DSGSD + DQE S + S+S++ E S ++ + DS+DE
Sbjct: 52 DSDTE----DSGSDENLDQE-LLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTF 106
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHH 129
G++ + + + + + + SD D + S AP +EG SD S+
Sbjct: 107 GSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAP----EEGEVSDSDSNS 162
Query: 130 SEAEGSEKAHSDDEK----WGREDKSDQSDDEKIQNSDDEERAQG-----SDEDKLQNSD 180
S + + S+DE+ +G + D+ D +++ ++ER Q + L+
Sbjct: 163 SSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRF 222
Query: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDD--EEQPQLS 238
+ +K T ++ + ++++ E++K E V S N + + D+ +++ Q
Sbjct: 223 EIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAM 282
Query: 239 DE-----EKMQNSDDE-----RPQASDEEHRHSDDEEEQDHKSE----SARGSDSEDE 282
+E EK +N E +P + E + ++EEE D SE S+R S S++E
Sbjct: 283 EELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEE 340
Score = 66.6 bits (161), Expect = 7e-11
Identities = 80/348 (22%), Positives = 141/348 (40%), Gaps = 47/348 (13%)
Query: 35 ASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERS 94
A G S + RG + K DS+ E SGSD + ++ +RS
Sbjct: 22 AGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTED----SGSDENLDQELLSLAKRKRS 77
Query: 95 DHEDNDP--SDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSD 152
D E+ +P S S SE + D++ S+ +A EK + ++ + S
Sbjct: 78 DSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSG 137
Query: 153 QSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE------RPQLSDDE----RQ 202
SD + S E + SD D +S + +++DEE + D+E +
Sbjct: 138 SSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLE 197
Query: 203 QLSEEEKA----NSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ------ 252
Q++E+E+ N ++R V + K+ ++ + +++K Q + E+ +
Sbjct: 198 QMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQE 257
Query: 253 ---ASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIA---------SDSEADS 300
S + R S +E+ D KS++ +E R KRKN A SE S
Sbjct: 258 SQVTSHNKERRSKRDEKLDKKSQAMEELKAE----REKRKNRTAELLAKKQPLKTSEVYS 313
Query: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKP--PTPGQPVDENGLPQD 346
D E +++ + + + SS + E+K P QPV LP++
Sbjct: 314 DDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPV---SLPEE 358
Score = 62.4 bits (150), Expect = 1e-09
Identities = 58/274 (21%), Positives = 114/274 (41%), Gaps = 10/274 (3%)
Query: 21 SDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNH 80
SDS + D+ S N ++ + E+ + + + S D+ +S S +
Sbjct: 93 SDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEE 152
Query: 81 SERSDNRSEASERSDHEDNDPSDVDQHS--GSEAPNDDEDEGHRSDGGSHHSEAEGSEKA 138
E SD+ S +S S D+ D + H G + D+ED E E +
Sbjct: 153 GEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI 212
Query: 139 HSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD 198
+ R + + K + ++++ Q +++K + + E + ++ER D
Sbjct: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRD 272
Query: 199 ---DERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASD 255
D++ Q EE KA + + ++ +KQ E SD+E+ + DD+ + SD
Sbjct: 273 EKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE--VYSDDEE-EEEDDKSSEKSD 329
Query: 256 EEHR--HSDDEEEQDHKSESARGSDSEDEVLRMK 287
R SD+EEE++ ++ +E+ R++
Sbjct: 330 RSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
Score = 54.3 bits (129), Expect = 4e-07
Identities = 51/233 (21%), Positives = 91/233 (39%), Gaps = 14/233 (6%)
Query: 10 SDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDE 69
SD DS AE + G SDSD +++S S++ S D++ G+ +L GD+ ED
Sbjct: 139 SDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGE----DLMGDE-EDR 193
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHH 129
+ NR E E + E + + +
Sbjct: 194 ARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLT 253
Query: 130 SEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTD 189
E +H+ + R K D+ D+K Q ++ + ++ +K +N + +
Sbjct: 254 QIQESQVTSHNKE----RRSKRDEKLDKKSQAMEELK----AEREKRKNRTAELLAKKQP 305
Query: 190 DEERPQLSDDERQQLSEEEKANSD-DERPVASDNDDEKQNSDDEEQPQLSDEE 241
+ SDDE ++ ++ SD R +SD ++EK+ + QP EE
Sbjct: 306 LKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEE 358
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/160 (25%), Positives = 62/160 (38%), Gaps = 15/160 (9%)
Query: 218 VASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ--------ASDEEHRHSDDE----E 265
V D+D E SD+ +L K + SD E + +SD E SDDE
Sbjct: 49 VVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGS 108
Query: 266 EQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTM---DLFGGADDIS 322
++ K AR + + + + K A + S+ DS E G + D +
Sbjct: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168
Query: 323 SGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362
S S ED+ G D G +D+ E + E E E+
Sbjct: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQEL 208
Score = 34.7 bits (78), Expect = 0.29
Identities = 48/262 (18%), Positives = 110/262 (41%), Gaps = 30/262 (11%)
Query: 406 EEGRTRLKLKVENTIRWRIRRD-EEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPL 464
++G+ R K++ + T++ + + G+ K+S+A +G +S N +
Sbjct: 113 KKGKAR-KIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDS 171
Query: 465 QGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMA 524
+ G L G + +L + T ++ L +R K + ++
Sbjct: 172 SSEDEEFHDGYGEDLMGDEEDRARL-------EQMTEKEREQELFNRIEKREVLK----- 219
Query: 525 GRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEES 584
R E ++ K++E+ ++E +Q + + Q Q S+ + R +E+ ++
Sbjct: 220 -RRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDK- 277
Query: 585 ISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAED 644
K++ ++ ER + + +E ++ LK ++ SD+E E + +E
Sbjct: 278 ------KSQAMEELKAEREK----RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEK 327
Query: 645 DDKANKKHKKYVISDEEEEDDD 666
D++++ SDEEEE ++
Sbjct: 328 SDRSSRTSS----SDEEEEKEE 345
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 69.7 bits (169), Expect = 8e-12
Identities = 73/329 (22%), Positives = 115/329 (34%), Gaps = 34/329 (10%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG-QPSNKELFGDDSEDEGAS 72
S ER S +DS + +A AS + SD+ RG SG Q S+ E ++S+ + S
Sbjct: 379 SPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVS 438
Query: 73 HH--SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHS 130
H +G S + R + ERS + V H ++ + GSHH
Sbjct: 439 GHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHE 498
Query: 131 EAEGSE------------KAHSDDEKWGREDKSDQSDDEKIQNSDDEE---RAQGSDEDK 175
+A S + H + GR+ + + +S +QG +
Sbjct: 499 QARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDAS 558
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANS--DDER-----------PVASDN 222
S + T +EE Q D R S +A+S D R P S N
Sbjct: 559 HGQSGSRSASRQTRNEE--QSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRN 616
Query: 223 DDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDE 282
+ D + Q D E+ S S +E + H + A S D
Sbjct: 617 QGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADS 676
Query: 283 VLRM-KRKNAIASDSEADSDTEVPKDNSG 310
+ R +S +A S E + ++G
Sbjct: 677 SRKSGTRHTQNSSSGQAASSHEQARSSAG 705
Score = 64.7 bits (156), Expect = 3e-10
Identities = 71/329 (21%), Positives = 114/329 (34%), Gaps = 34/329 (10%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG-QPSNKELFGDDSEDEGAS 72
S ER S +DS + + AS + D RG SG Q S+ E +DS+ + S
Sbjct: 2325 SAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVS 2384
Query: 73 HH--SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHS 130
H +G S + R ++ RS + V H SE+ + GSHH
Sbjct: 2385 AHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHK 2444
Query: 131 EAEGSEK------------AHSDDEKWGREDKSDQSDDEKIQNSDDEE---RAQGSDEDK 175
+A S + H GR+ + ++ +S +QG +
Sbjct: 2445 QARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDAS 2504
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANS-------------DDERPVASDN 222
+S + T ++E Q D R S +A+S E P S N
Sbjct: 2505 HGHSGSRSASRQTRNDE--QSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRN 2562
Query: 223 DDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDE 282
+ D + Q D E+ S S +E + H+ + A S D
Sbjct: 2563 WGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADS 2622
Query: 283 VLRM-KRKNAIASDSEADSDTEVPKDNSG 310
+ R +S +A S E + ++G
Sbjct: 2623 SRQSGTRHTQTSSGGQAASSHEQARSSAG 2651
Score = 63.2 bits (152), Expect = 8e-10
Identities = 82/343 (23%), Positives = 120/343 (34%), Gaps = 58/343 (16%)
Query: 11 DADSEAERKDSD--SGSDS----DSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD 64
D+DSE DS+ SGS S S +E + GS G Q++R G +
Sbjct: 1273 DSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFH--QEDRASHGHSA------- 1323
Query: 65 DSEDEGASHHSGSDNH----SERSDNRSEASERSDHEDNDPSDVDQHSG---SEAPNDDE 117
DS + +HH+ S +H S RS ER +D +HSG +A +
Sbjct: 1324 DSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVR 1383
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDD------EKWGREDKSDQSDDEKIQNSDDEERAQGS 171
D GHR GS + +EG HS+D G+ QS E + E + G
Sbjct: 1384 DSGHRGSSGSQVTNSEG----HSEDSDTQSVSAHGQAGPHQQSHKESARGQSGE--SSGR 1437
Query: 172 DEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE------ 225
L E+ ++T + P +Q S E+A + + D D
Sbjct: 1438 SRSFLYQVSSHEQSESTHGQTAPSTGG---RQGSRHEQARNSSRHSASQDGQDTIRGHPG 1494
Query: 226 -----KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDD--------EEEQDHKSE 272
+Q S E+ S +S SD H S EEQ
Sbjct: 1495 SSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGS 1554
Query: 273 SARGSDSEDEVLR--MKRKNAIASDSEADSDTEVPKDNSGTMD 313
GS + R R + + A S T + +S + D
Sbjct: 1555 RHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQD 1597
Score = 62.8 bits (151), Expect = 1e-09
Identities = 81/347 (23%), Positives = 117/347 (33%), Gaps = 54/347 (15%)
Query: 8 FGSDADSEAERKDSD--SGSDS----DSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
F D+DS+ +DS+ SGS S S QE GS S Q++R G +
Sbjct: 2567 FSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHP--RSHQEDRAGHGHSA---- 2620
Query: 62 FGDDSEDEGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSG---SEAPND 115
D S G H SG S RS A ER +D +HSG +A +
Sbjct: 2621 --DSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSA 2678
Query: 116 DEDEGHRSDGGSHHSEAEG------------------SEKAHSDDEKWGREDKSDQSDDE 157
D GHR GS S+ EG +++H + + + S S
Sbjct: 2679 VRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSF 2738
Query: 158 KIQNSDDEER-------------AQGSDEDKLQNSDDDEKMQNTDDEER--PQLSDDERQ 202
Q S E+ QGS ++ Q+S Q+ D R P S RQ
Sbjct: 2739 LYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQ 2798
Query: 203 QLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSD 262
E +S + + Q D + Q + + +E H S
Sbjct: 2799 GYHHEHSVDSSGHSG-SHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSR 2857
Query: 263 DEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNS 309
E H S + + +R S DSD+E ++S
Sbjct: 2858 HHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDS 2904
Score = 62.4 bits (150), Expect = 1e-09
Identities = 64/291 (21%), Positives = 103/291 (35%), Gaps = 25/291 (8%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG-QPSNKELFGDDSEDEGAS 72
S ER S +DS + + AS + D RG SG Q S+ E +DS+ + S
Sbjct: 3621 SAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVS 3680
Query: 73 HH--SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEA------PNDDEDEGHR-- 122
H +G S + R ++ RS + V H SE+ P+ +G R
Sbjct: 3681 AHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHE 3740
Query: 123 --SDGGSHHSEAEGSE--KAHSDDEKWGREDK-SDQSDDEKIQNSDDEERAQGSDEDKLQ 177
D H + EG + + H + GR+ +QS D +
Sbjct: 3741 QARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDAS 3800
Query: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEKAN--SDDERPVASDNDDEKQNSDDEEQ- 234
+ + + + Q D R S +A+ +D R S + + Q
Sbjct: 3801 HGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQG 3860
Query: 235 ---PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD---HKSESARGSDS 279
Q SD E + R +++ H S E+ +D H S R + S
Sbjct: 3861 SSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHRDTAS 3911
Score = 61.2 bits (147), Expect = 3e-09
Identities = 77/358 (21%), Positives = 132/358 (36%), Gaps = 49/358 (13%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
D + S + S SD + SGS ++ ++ +D++ GD S G
Sbjct: 1186 DRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQS-----------GDGSRHSG 1234
Query: 71 ASHH-----SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
+ HH + S HS+ +S S S H+ S V Q S SE +DD + S
Sbjct: 1235 SRHHEAASWADSSRHSQVGQEQSSGSRTSRHQG---SSVSQDSDSERHSDDSERLSGSAS 1291
Query: 126 GSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
+HH + + S + +ED++ +S D R G+ +++
Sbjct: 1292 RNHHGSSREQSRDGSRHPGFHQEDRASHG------HSADSSRQSGT-----HHTESSSHG 1340
Query: 186 QNTDDEERPQLSDDER-----QQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 240
Q E+ + S ER QQ ++ + + R +S D Q + E
Sbjct: 1341 QAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQ-VTNSE 1399
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 300
++SD + A + H +Q HK ESARG E ++S +++S
Sbjct: 1400 GHSEDSDTQSVSAHGQAGPH-----QQSHK-ESARGQSGESSGRSRSFLYQVSSHEQSES 1453
Query: 301 DTEVPKDNSG-----TMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPI 353
++G + + S+ DG+D G P G Q E+ +
Sbjct: 1454 THGQTAPSTGGRQGSRHEQARNSSRHSASQDGQD--TIRGHPGSSRGGRQGSYHEQSV 1509
Score = 60.5 bits (145), Expect = 5e-09
Identities = 65/299 (21%), Positives = 108/299 (36%), Gaps = 25/299 (8%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDE-RGDSGQPSNKELFGDDSEDEGA 71
DS R + +G S E A S S S+ QD RG G +
Sbjct: 479 DSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNR 538
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSE 131
S HSGS + S RS+AS H + + + +E + D G R G HH
Sbjct: 539 SGHSGSHHSHTTSQGRSDAS----HGQSGSRSASRQTRNEEQSGD---GTRHSGSRHH-- 589
Query: 132 AEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDE 191
E S +A S R + Q + S ++ + D D +S+D E+ +
Sbjct: 590 -EASSQADSS-----RHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASR 643
Query: 192 ERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERP 251
+ ++ + S +++ +D D +++ Q S + +S ++
Sbjct: 644 NHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSG--TRHTQNSSSGQAASSHEQAR 701
Query: 252 QASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR----MKRKNAIASDSEA---DSDTE 303
++ E H + D S G +R + A+DSE DSDT+
Sbjct: 702 SSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQ 760
Score = 58.9 bits (141), Expect = 1e-08
Identities = 73/310 (23%), Positives = 104/310 (33%), Gaps = 39/310 (12%)
Query: 19 KDSDS-GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL-----FGDDSEDEGAS 72
+DSDS G DS++ + ++ N GS +Q G S+ E +S + +
Sbjct: 2245 QDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGT 2304
Query: 73 HH----SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSG---SEAPNDDEDEGHRSDG 125
HH SG S RS A ER +D +HSG +A + D GHR
Sbjct: 2305 HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSS 2364
Query: 126 GSHHSEAEGSEKAHSDD------EKWGREDKSDQSDDEKIQ-NSDDEERAQGSDEDKLQN 178
GS S++EG HS+D G+ QS E + S GS ++
Sbjct: 2365 GSQASDSEG----HSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVST 2420
Query: 179 SDDDEKMQ--------NTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
+ E Q D R S+E D + +Q S
Sbjct: 2421 HEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQE---GQDTIHGHPGSSSGGRQGSH 2477
Query: 231 DEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKN 290
E+ S +S SD H HS S R + + R
Sbjct: 2478 YEQLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRS----ASRQTRNDEQSGDGSRHSGSR 2533
Query: 291 AIASDSEADS 300
+ S ADS
Sbjct: 2534 HHEASSRADS 2543
Score = 58.5 bits (140), Expect = 2e-08
Identities = 62/283 (21%), Positives = 99/283 (34%), Gaps = 35/283 (12%)
Query: 9 GSDA-DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
GS A DSE +DSD+ S S Q A S ES +D G+ + S L+ +
Sbjct: 744 GSQATDSEGHSEDSDTQSVSGHGQ---AGHHQQSHQESARDRSGERSRRSGSFLYQVSTH 800
Query: 68 DEGASHHSGSD--------NHSERSDNRSEASERSDHEDNDPSDVDQHSGS-----EAPN 114
+ S H + +H E++ + S S D +D + H GS + +
Sbjct: 801 KQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDT----IRGHPGSSRRGRQGSH 856
Query: 115 DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED 174
++ GSHHS GR D S + + Q D
Sbjct: 857 HEQSVDRSGHSGSHHSHTTSQ----------GRSDASRGQSGSRSASRTTRNEEQSRDGS 906
Query: 175 KLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
+ S E + D Q Q SE + + V+ D+D E + D E
Sbjct: 907 RHSGSRHHEASSHADISRHSQAG----QGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERW 962
Query: 235 PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGS 277
+ ++ ++ S H +D H ++S+R S
Sbjct: 963 SGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQS 1005
Score = 57.4 bits (137), Expect = 4e-08
Identities = 69/324 (21%), Positives = 113/324 (34%), Gaps = 28/324 (8%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G S R+ DS + + S+ + RG SG S ++ +
Sbjct: 2788 GHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQS 2847
Query: 69 EGASHHSGS-----------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDE 117
S HSGS HS+ +SE S RS + S V Q S SE ++D
Sbjct: 2848 GDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRRSRRQG---SSVSQDSDSEGHSEDS 2904
Query: 118 DEGHRSDGGSHHSEA-----EGSEKAHS-DDEKWGREDKSDQSDDEKIQNSDDEERAQGS 171
+ S +HH A +GS S +++ G +D S +++ Q +
Sbjct: 2905 ERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAA 2964
Query: 172 DEDKLQNSDDDEK----MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQ 227
+ S E+ Q + D R + + + + ASDN+ +
Sbjct: 2965 SSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSE 3024
Query: 228 NSDDEEQPQLSDEEKMQNSDDERPQA-SDEEHRHSDD---EEEQDHKSESARGSDSEDEV 283
+SD + Q S E + S E HS + +SES+ G
Sbjct: 3025 DSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTR 3084
Query: 284 LRMKRKNAIASDSEADSDTEVPKD 307
R ++ A DS S ++ +D
Sbjct: 3085 GRQGSRHEQAQDSSRHSASQYGQD 3108
Score = 57.0 bits (136), Expect = 5e-08
Identities = 71/344 (20%), Positives = 124/344 (36%), Gaps = 53/344 (15%)
Query: 19 KDSDS-GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+D DS G DS++ + ++ N GS +Q G S+ E +S SG+
Sbjct: 299 QDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGT 358
Query: 78 DNHSERSDN----------RSEASERSDHEDNDPSDVDQHSGS---EAPNDDEDEGHRSD 124
H+E S RS ER +D +HS + +A + D GHR
Sbjct: 359 -RHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGS 417
Query: 125 GGSHHSEAEG------------------SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEE 166
GS S++EG +++H + + ++S +S Q S E+
Sbjct: 418 SGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQ 477
Query: 167 -------------RAQGSDEDKLQNSDDDEKMQNTDDEER--PQLSDDERQQLSEEEKAN 211
QGS ++ ++S Q D R P S RQ E+ N
Sbjct: 478 PDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVN 537
Query: 212 SDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDER----PQASDEEHRHSDDEEEQ 267
+ + SD S Q ++E+ + S H + + +
Sbjct: 538 RSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADS 597
Query: 268 DHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
S+ +G S R + ++++ DS++ +E + SG+
Sbjct: 598 SRHSQVGQGQSSGPRTSR-NQGSSVSQDSDSQGHSEDSERWSGS 640
Score = 57.0 bits (136), Expect = 5e-08
Identities = 65/327 (19%), Positives = 107/327 (32%), Gaps = 34/327 (10%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G S R+ S D + + S+ + RG SG S ++ +
Sbjct: 843 GHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQS 902
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
S HSGS +H S ++ ++ S + GS D + EGH D
Sbjct: 903 RDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERW 962
Query: 129 HSEAEGSEKAHSDDEK--WGREDKSDQSDDEKIQNSDDEERAQGSDEDKL----QNSDDD 182
A + + + ++ R +S D +S D R G+ + Q +
Sbjct: 963 SGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSH 1022
Query: 183 EKMQNTDDE---ERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSD 239
E+ +++ E R Q S D + + S R Q SD E + SD
Sbjct: 1023 EQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESD 1082
Query: 240 EEKMQNSDDERPQASDEEHRHSDDEEEQD-------------------HKSESARGSDSE 280
+ + + P H+ S E +D +SESA G
Sbjct: 1083 TQSVSGHGQDGP------HQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRT 1136
Query: 281 DEVLRMKRKNAIASDSEADSDTEVPKD 307
R + A DS S ++ +D
Sbjct: 1137 STGRRQGSHHEQARDSSRHSASQEGQD 1163
Score = 57.0 bits (136), Expect = 5e-08
Identities = 83/360 (23%), Positives = 129/360 (35%), Gaps = 31/360 (8%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G S R+ S DS + + S+ + E RG SG S ++ +
Sbjct: 1815 GHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQS 1874
Query: 69 EGASHHSGSDNH--SERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD-- 124
S HSGS +H S R+D+ S S+ + + P ++ GS D + +GH D
Sbjct: 1875 GDGSRHSGSRHHEASSRADS-SRHSQVGQGQSSGPR-TSRNQGSSVSQDSDSQGHSEDSE 1932
Query: 125 --GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
GS GS S D R S D +S D R G+ ++++
Sbjct: 1933 RWSGSASRNHLGSAWEQSRD--GSRHPGSHHEDRAGHGHSADSSRQSGT-----RHTESS 1985
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDE-----EQPQL 237
+ Q E+ + S ER S + ++D R + D Q
Sbjct: 1986 SRGQAASSHEQARSSAGERHG-SHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQA 2044
Query: 238 SDEE-KMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS-- 294
SD E ++SD + A + H +Q HK ESARG E +++
Sbjct: 2045 SDSEGHSEDSDTQSVSAQGKAGPH-----QQSHK-ESARGQSGESSGRSGSFLYQVSTHE 2098
Query: 295 DSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPT-PGQPVDENGLPQDQQEEEPI 353
SE+ P + A D S S ++ T G P G Q +E+ +
Sbjct: 2099 QSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSV 2158
Score = 56.6 bits (135), Expect = 7e-08
Identities = 67/314 (21%), Positives = 105/314 (33%), Gaps = 33/314 (10%)
Query: 9 GSDADSEAERKDSDS--------GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
G A S+ R+ S G DS++ + ++ N GS +Q G S++E
Sbjct: 1579 GESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQE 1638
Query: 61 ------LFGDDSEDEGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE 111
+ S G H SG S + RS ER +D SG+
Sbjct: 1639 DRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTG 1698
Query: 112 APNDDE---DEGHRSDGGSHHSEAEG-SEKAHSDD-EKWGREDKSDQSDDEKIQNSDDEE 166
D D G+R GS S++EG SE++ + G+ QS E + E
Sbjct: 1699 RRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQESTRGQSGER 1758
Query: 167 RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEK 226
G L E+ ++ P +R S E+A + + D
Sbjct: 1759 --SGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQR---SRHEQARDSSRHSASQEGQDTI 1813
Query: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRM 286
+ + Q+ D S H H+ +E +S+ +RG V R
Sbjct: 1814 RGHPGSSRGGRQGSHYEQSVDSSGHSGS--HHSHTTSQE----RSDVSRGQSGSRSVSRQ 1867
Query: 287 KRKNAIASDSEADS 300
R + D S
Sbjct: 1868 TRNEKQSGDGSRHS 1881
Score = 56.2 bits (134), Expect = 9e-08
Identities = 62/282 (21%), Positives = 105/282 (37%), Gaps = 33/282 (11%)
Query: 9 GSDA-DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
GS A DSE ++SD+ S S Q+ S+ ES +D G S ++ +
Sbjct: 1068 GSQASDSEGHSEESDTQSVSGHGQDGPHQQSH---QESARDWSGGRSGRSGSFIYQVSTH 1124
Query: 68 DEGASHHSGS--------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE 119
++ S H + +H E++ + S S + +D + G + E
Sbjct: 1125 EQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQS 1184
Query: 120 GHRSD-GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQN 178
RS GSHHS ++ + + G S Q+ +K S D R GS + +
Sbjct: 1185 VDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDK--QSGDGSRHSGSRHHEAAS 1242
Query: 179 SDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLS 238
D + E+ S + + V+ D+D E+ + D E +LS
Sbjct: 1243 WADSSRHSQVGQEQ------------SSGSRTSRHQGSSVSQDSDSERHSDDSE---RLS 1287
Query: 239 DEEKMQNSDDERPQASDEEHR---HSDDEEEQDHKSESARGS 277
+ R Q+ D H +D H ++S+R S
Sbjct: 1288 GSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQS 1329
Score = 55.5 bits (132), Expect = 2e-07
Identities = 62/298 (20%), Positives = 105/298 (35%), Gaps = 31/298 (10%)
Query: 10 SDADSEAERKDSDS-------GSDSDSDQENAASGSNA----SGS--------ESDQDER 50
SD++ +E D+ S G S QE+A S SGS E +
Sbjct: 3341 SDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAH 3400
Query: 51 GDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQ--HS 108
G + + + + +S HS S + +S R + VD+ HS
Sbjct: 3401 GRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHS 3460
Query: 109 G---SEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDD---EKWGREDKSDQSDDEKIQNS 162
G S + + R GS + + S D W ++ D +
Sbjct: 3461 GSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQ 3520
Query: 163 DDEERAQGSDEDKLQN---SDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVA 219
+ ++ G + Q S D + +++D ER S + S +E++ D R
Sbjct: 3521 SGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSR-DGSRHPT 3579
Query: 220 SDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGS 277
S ++D + E + S +NS + +S E+ R S E H +SA S
Sbjct: 3580 SHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSS 3637
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/292 (20%), Positives = 104/292 (35%), Gaps = 31/292 (10%)
Query: 9 GSDADSEAERKDSDSGSDS--------------DSDQENAASGSNASGSESDQDERGDSG 54
GS + S RKD SG S DS + + +SGS + + +
Sbjct: 1212 GSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVS 1271
Query: 55 QPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPN 114
Q S+ E DDSE SGS + + +R ++ + S H D H G A +
Sbjct: 1272 QDSDSERHSDDSE-----RLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASH-GHSADS 1325
Query: 115 DDEDEGHRSDGGSHHSEAEGSEKAHSD-DEKWGREDKSDQSDDEKIQNSDDEERAQGSDE 173
+ H ++ SH E+A S E+ G + QS D + +A +
Sbjct: 1326 SRQSGTHHTESSSHGQAVSSHEQARSSPGERHG--SRHQQSADSSRHSGIGHRQASSAVR 1383
Query: 174 DKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKA--NSDDERPVASDNDDEKQNSDD 231
D ++ N++ D + Q +S +A + + A E
Sbjct: 1384 DSGHRGSSGSQVTNSEGHS----EDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSR 1439
Query: 232 EEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV 283
Q+S E+ +++ + A R E+ + S + D +D +
Sbjct: 1440 SFLYQVSSHEQSESTHGQ--TAPSTGGRQGSRHEQARNSSRHSASQDGQDTI 1489
Score = 54.3 bits (129), Expect = 4e-07
Identities = 64/313 (20%), Positives = 101/313 (32%), Gaps = 38/313 (12%)
Query: 22 DSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHS 81
D S + + S R S Q N+E GD S HSGS +H
Sbjct: 1510 DRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGD------GSRHSGSRHHE 1563
Query: 82 ERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSE--KAH 139
+ S + ++ S + GS D + EGH D A + A
Sbjct: 1564 PSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAR 1623
Query: 140 SDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDD 199
R +S Q D +S + R G+ ++++ Q +E+ + S
Sbjct: 1624 EQSRHGSRNPRSHQEDRASHGHSAESSRQSGT-----RHAETSSGGQAASSQEQARSSPG 1678
Query: 200 ERQQLSEEEKANSDDERPVASDNDDE------------KQNSDDEEQPQLSDEEKMQNSD 247
ER ++ A+S + D Q SD E + SD + +
Sbjct: 1679 ERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHG 1738
Query: 248 DERP-QASDEEHRHSDDEEEQ------------DHKSESARGSDSEDEVLRMKRKNAIAS 294
P Q S +E E +SESA G R + ++ A
Sbjct: 1739 QAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQAR 1798
Query: 295 DSEADSDTEVPKD 307
DS S ++ +D
Sbjct: 1799 DSSRHSASQEGQD 1811
Score = 54.3 bits (129), Expect = 4e-07
Identities = 66/279 (23%), Positives = 93/279 (33%), Gaps = 45/279 (16%)
Query: 22 DSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDN-- 79
DS S S + S + S R S N+E GD S + HH S +
Sbjct: 3131 DSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHAD 3190
Query: 80 ---HSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD----GGSHHSEA 132
HS+ +SE S RS + GS D + EGH D GS
Sbjct: 3191 ISRHSQAVQGQSEGSRRS-----------RRQGSSVSQDSDSEGHSEDSERWSGSASRNH 3239
Query: 133 EGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
GS + S R +S D +S D R G+ ++++ Q E
Sbjct: 3240 RGSVQEQS--RHGSRHPRSHHEDRAGHGHSADRSRQSGT-----RHAETSSGGQAASSHE 3292
Query: 193 RPQLSDDE----RQQLSEEEKANSDDERPVASD--------NDDEKQNSDDEEQPQLSDE 240
+ + S E R Q S + +S R AS Q SD E + SD
Sbjct: 3293 QARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDT 3352
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDS 279
+ + P H+ S E +D + S S
Sbjct: 3353 QSVSGHGQAGP------HQQSHQESARDRSGGRSGRSGS 3385
Score = 53.1 bits (126), Expect = 8e-07
Identities = 39/163 (23%), Positives = 57/163 (34%), Gaps = 8/163 (4%)
Query: 22 DSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH-----SG 76
D S S + S + S R S + N+E GD S G+ HH +
Sbjct: 3779 DRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQAD 3838
Query: 77 SDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSE 136
S HS+ S S RS + S V Q S SEA +D + S +HH +
Sbjct: 3839 SSRHSQSGQGESAGSRRSRRQG---SSVSQDSDSEAYPEDSERRSESASRNHHGSSREQS 3895
Query: 137 KAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNS 179
+ S D + +Q+ + G Q+S
Sbjct: 3896 RDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDS 3938
Score = 52.4 bits (124), Expect = 1e-06
Identities = 69/315 (21%), Positives = 105/315 (33%), Gaps = 42/315 (13%)
Query: 22 DSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHS 81
D S S + S + S R S Q N E GD S HSGS +H
Sbjct: 2483 DRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGD------GSRHSGSRHHE 2536
Query: 82 ERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD----GGSHHSEAEGSEK 137
S S + ++ ++ GS D + +GH D GS GS +
Sbjct: 2537 ASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQ 2596
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLS 197
D R +S Q D +S D R G+ +++ Q E+ + S
Sbjct: 2597 EQLRD--GSRHPRSHQEDRAGHGHSADSSRQSGT-----RHTQTSSGGQAASSHEQARSS 2649
Query: 198 DDERQQLSEEEKANSDDERPV---------------------ASDNDDEKQNSDDEEQPQ 236
ER ++ A+S + ASDN+ ++SD +
Sbjct: 2650 AGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSA 2709
Query: 237 LSDEEKMQNSDDERPQA-SDEEHRHSDD---EEEQDHKSESARGSDSEDEVLRMKRKNAI 292
Q S E + S E HS + +SES+ G R ++
Sbjct: 2710 HGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQ 2769
Query: 293 ASDSEADSDTEVPKD 307
A DS S ++ +D
Sbjct: 2770 AQDSSRHSASQDGQD 2784
Score = 52.0 bits (123), Expect = 2e-06
Identities = 59/307 (19%), Positives = 103/307 (33%), Gaps = 16/307 (5%)
Query: 17 ERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSG 76
+ + D S S + S + S R S + +KE GD S G+ HH
Sbjct: 2154 QEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEA 2213
Query: 77 SDNHSERSDNRSEASERSDHEDNDP--SDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
S + + S + P S V Q S SE ++D + S +HH A+
Sbjct: 2214 SSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQE 2273
Query: 135 SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM--------- 185
+ S + ED++ + A+ S + +S + +
Sbjct: 2274 QSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSH 2333
Query: 186 -QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
Q + D R + + + + ASD++ ++SD + Q
Sbjct: 2334 HQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQ 2393
Query: 245 NSDDE--RPQASDEEHRHSD--DEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 300
S E R +++ R + +SESA G R + A DS S
Sbjct: 2394 QSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHS 2453
Query: 301 DTEVPKD 307
++ +D
Sbjct: 2454 TSQEGQD 2460
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/298 (20%), Positives = 100/298 (33%), Gaps = 56/298 (18%)
Query: 27 SDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHS----------- 75
+DS + + AS + D RG SG + S+ EG S S
Sbjct: 2014 ADSSRHSGIGHGQASSAVRDSGHRGYSGSQA--------SDSEGHSEDSDTQSVSAQGKA 2065
Query: 76 GSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGS 135
G S + R ++ E S + V H SE+ + GSH+ +A+ S
Sbjct: 2066 GPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDS 2125
Query: 136 E------------KAHSDDEKWGRE--------DKSDQSDDE----KIQNSDDEERAQGS 171
+ H + GR+ D+S S Q D R Q
Sbjct: 2126 SRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSG 2185
Query: 172 DE-------DKLQNSDDDEKMQNTDDEERPQLSDDERQQL-SEEEKANSDDERP----VA 219
DK + S D + + E +D R L + + + RP V+
Sbjct: 2186 SRSASRKTYDK-EQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVS 2244
Query: 220 SDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGS 277
D+D E + D E + + ++ ++ S H +D H +ES+R S
Sbjct: 2245 QDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQS 2302
Score = 50.4 bits (119), Expect = 5e-06
Identities = 65/338 (19%), Positives = 112/338 (33%), Gaps = 27/338 (7%)
Query: 12 ADSEAERKDSDSGSDSDSDQENAASGSNASGSE-------SDQDERGDSGQPSNKELFGD 64
+D+ + S S S + ++E + GS SGS +D +GQ ++
Sbjct: 880 SDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTS 939
Query: 65 DSEDEGASHHSGSDNHSERSD---------NRSEASERSDHEDNDPSDVDQHSGSEAPND 115
+ S S S+ HSE S+ +R A E+S H P H A +
Sbjct: 940 RRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPR---SHHEDRAGHG 996
Query: 116 DEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEE-----RAQG 170
+ R G H + G + A S ++ R ++ Q++D R Q
Sbjct: 997 HSADSSRQSGTPHAETSSGGQAASSHEQ--ARSSPGERHGSRHQQSADSSRHSGIPRRQA 1054
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
S + Q +D E + SD + ++ + + A D +
Sbjct: 1055 SSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRS 1114
Query: 231 DEEQPQLSDEEKMQNSDDE-RPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRK 289
Q+S E+ +++ R + H + + S S G D+ +R
Sbjct: 1115 GSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRG 1174
Query: 290 NAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
S E D + + G D S G G
Sbjct: 1175 GRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSG 1212
Score = 50.4 bits (119), Expect = 5e-06
Identities = 65/292 (22%), Positives = 104/292 (35%), Gaps = 36/292 (12%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G + K+S G +S + + S E + G S + +
Sbjct: 2063 GKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQA 2122
Query: 69 EGASHHSGSD-------------------NHSERSDNRS--EASERSDHEDNDPSDVDQ- 106
+ +S HS S +H E+S +RS S S SD +
Sbjct: 2123 QDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRG 2182
Query: 107 HSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE- 165
SGS + + + +S GS HS + H + W D S S + Q+S
Sbjct: 2183 QSGSRSASRKTYDKEQSGDGSRHSGSH-----HHEASSWA--DSSRHSLVGQGQSSGPRT 2235
Query: 166 ERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE 225
R +GS S D + +++D ER S S +E++ D R S ++D
Sbjct: 2236 SRPRGSSV-----SQDSDSEGHSEDSERRSGSASRNHHGSAQEQSR-DGSRHPRSHHEDR 2289
Query: 226 KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGS 277
+ E + S +NS + +S E+ R S E H +SA S
Sbjct: 2290 AGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSS 2341
Score = 50.4 bits (119), Expect = 5e-06
Identities = 73/351 (20%), Positives = 123/351 (35%), Gaps = 67/351 (19%)
Query: 19 KDSDS-GSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+DSDS G DS++ + ++ N GS +Q G S+ E + A H +
Sbjct: 3217 QDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHE--------DRAGHGHSA 3268
Query: 78 D-------NHSERSDN----------RSEASERSDHEDNDPSDVDQHSG---SEAPNDDE 117
D H+E S RS ER +D +HSG +A +
Sbjct: 3269 DRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVR 3328
Query: 118 DEGHRSDGGSHHSEAEG---------------------SEKAHSDDEKWGREDKS----- 151
D H GS S++EG S + + D GR +S
Sbjct: 3329 DSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLY 3388
Query: 152 -----DQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEER--PQLSDDERQQL 204
+QS+ + R QGS ++ ++S Q D R P S RQ
Sbjct: 3389 QVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGS 3448
Query: 205 SEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDER----PQASDEEHRH 260
E+ + + + SD S Q +DE+ + S H
Sbjct: 3449 HYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHE 3508
Query: 261 SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
+ + + S+S +G + R + ++++ DS++ +E + SG+
Sbjct: 3509 ASTQADSSRHSQSGQGQSAGPRTSR-NQGSSVSQDSDSQGHSEDSERWSGS 3558
Score = 49.7 bits (117), Expect = 9e-06
Identities = 68/333 (20%), Positives = 117/333 (35%), Gaps = 54/333 (16%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
D + + ++ S +DS + + +SG + +++ Q S+ + +DSE
Sbjct: 579 DGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWS 638
Query: 71 AS---HHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD--- 124
S +H GS R +R RS HED GH +D
Sbjct: 639 GSASRNHHGSAQEQSRDGSRHP---RSHHEDR-----------------AGHGHSADSSR 678
Query: 125 -GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD- 182
G+ H++ S +A S E+ R ++ S D R G+ + ++ D
Sbjct: 679 KSGTRHTQNSSSGQAASSHEQ-ARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDS 737
Query: 183 -----EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQL 237
Q TD E + SD + + + + A D E+ Q+
Sbjct: 738 GHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQV 797
Query: 238 SDEEKMQNS------------DDERPQASDEEHRHSDDEEEQD----HKSESAR---GSD 278
S ++ ++S QA D RHS ++ QD H S R GS
Sbjct: 798 STHKQSESSHGWTGPSTGVRQGSHHEQARDNS-RHSASQDGQDTIRGHPGSSRRGRQGSH 856
Query: 279 SEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
E V R + S + + ++ + SG+
Sbjct: 857 HEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGS 889
Score = 49.7 bits (117), Expect = 9e-06
Identities = 56/279 (20%), Positives = 89/279 (31%), Gaps = 15/279 (5%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G S R+ S D + + S+ + RG SG S D +
Sbjct: 2140 GHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQS 2199
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD---- 124
S HSGS +H S S + + GS D + EGH D
Sbjct: 2200 GDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERR 2259
Query: 125 GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEK 184
GS GS + S D R +S D +S + R G+ ++++
Sbjct: 2260 SGSASRNHHGSAQEQSRD--GSRHPRSHHEDRAGHGHSAESSRQSGT-----HHAENSSG 2312
Query: 185 MQNTDDEERPQLSDDERQQLSEEEKANSDDERPV----ASDNDDEKQNSDDEEQPQLSDE 240
Q E+ + S ER ++ A+S + AS + + E
Sbjct: 2313 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSE 2372
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDS 279
++SD + A + H +E + R S
Sbjct: 2373 GHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRS 2411
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/292 (17%), Positives = 106/292 (36%), Gaps = 19/292 (6%)
Query: 31 QENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHS----ERSDN 86
+EN + S D+ D+ Q NKE S E ++ G+ S E
Sbjct: 91 KENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGK 150
Query: 87 RSEAS-ERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG----------GSHHSEAEGS 135
R E+S E+ + + P+ ++ G N + E ++++ E E +
Sbjct: 151 RHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDN 210
Query: 136 EKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQ 195
E+ D E GR + ++ A + + L+ + E+ +++D + Q
Sbjct: 211 EEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQ 270
Query: 196 LSDDERQQLSE----EEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERP 251
++ + S+ E + V+ D D E + D E + ++ ++
Sbjct: 271 VNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSR 330
Query: 252 QASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
S H +D H ++S+R S + + + A + + S E
Sbjct: 331 DGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGE 382
Score = 49.3 bits (116), Expect = 1e-05
Identities = 54/279 (19%), Positives = 91/279 (32%), Gaps = 15/279 (5%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G S R+ S D + + S+ + RG SG S +D +
Sbjct: 3436 GHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQS 3495
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD---- 124
S HS S +H + S +S + ++ GS D + +GH D
Sbjct: 3496 GDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERW 3555
Query: 125 GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEK 184
GS GS + S D R S D +S + R G+ ++++
Sbjct: 3556 SGSASRNHRGSAQEQSRD--GSRHPTSHHEDRAGHGHSAESSRQSGT-----HHAENSSG 3608
Query: 185 MQNTDDEERPQLSDDERQQLSEEEKANSDDERPV----ASDNDDEKQNSDDEEQPQLSDE 240
Q E+ + S ER ++ A+S + AS + + E
Sbjct: 3609 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSE 3668
Query: 241 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDS 279
++SD + A + H +E + R S
Sbjct: 3669 GHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRS 3707
Score = 48.5 bits (114), Expect = 2e-05
Identities = 67/347 (19%), Positives = 117/347 (33%), Gaps = 33/347 (9%)
Query: 9 GSDADSEAERKDSDSGSDS-DSDQENAASGSNASGSESDQDERGDSGQPSNKELFGD--- 64
G + S R + SG S S + + A S Q +G+S G
Sbjct: 1536 GPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVS 1595
Query: 65 -DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
D + EG S S + S ++ A E+S H +P H A + E R
Sbjct: 1596 QDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPR---SHQEDRASHGHSAESSRQ 1652
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE-ERAQGSDEDKLQNSDDD 182
G H + G + A S ++ R ++ Q++D + G +D D
Sbjct: 1653 SGTRHAETSSGGQAASSQEQ--ARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSG 1710
Query: 183 EK----MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLS 238
+ Q +D E + SD + + + + E+ Q+S
Sbjct: 1711 NRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVS 1770
Query: 239 DEEKMQNS-----------DDERPQASDEEHRHSDDEEEQD----HKSES---ARGSDSE 280
E+ +++ R + + + RHS +E QD H S +GS E
Sbjct: 1771 THEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYE 1830
Query: 281 DEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
V + S + + ++V + SG+ + + DG
Sbjct: 1831 QSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDG 1877
Score = 47.8 bits (112), Expect = 3e-05
Identities = 63/352 (17%), Positives = 109/352 (30%), Gaps = 43/352 (12%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
G + K+S G +S + + S E + G + + +
Sbjct: 1414 GQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQA 1473
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH 128
+S HS S + + +S VD+ GH G H
Sbjct: 1474 RNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDR------------SGH---SGYH 1518
Query: 129 HSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNT 188
HS ++ + + G S Q+ +E + S D R GS
Sbjct: 1519 HSHTTPQGRSDASHGQSGPRSASRQTRNE--EQSGDGSRHSGS----------------R 1560
Query: 189 DDEERPQLSDDERQQLSEEEKANSDDER----PVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
E + Q+ + E A S R V+ D D E + D E + + +
Sbjct: 1561 HHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYG 1620
Query: 245 NSDDERPQASDEEHRHSDDEEEQDHKSESARGS------DSEDEVLRMKRKNAIASDSEA 298
++ ++ S H +D H +ES+R S S ++ A +S E
Sbjct: 1621 SAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGER 1680
Query: 299 DSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEE 350
+S T G D S D ++ + Q D G ++ +
Sbjct: 1681 HGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQ 1732
Score = 46.2 bits (108), Expect = 1e-04
Identities = 68/332 (20%), Positives = 115/332 (34%), Gaps = 53/332 (15%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
D+ + + ++ + +D + + A + GS + + Q S+ E +DSE
Sbjct: 3173 DSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWS 3232
Query: 71 AS---HHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSD--- 124
S +H GS R +R RS HED GH +D
Sbjct: 3233 GSASRNHRGSVQEQSRHGSRHP---RSHHEDR-----------------AGHGHSADRSR 3272
Query: 125 -GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDE 183
G+ H+E +A S E+ + + Q S D R G + ++ D
Sbjct: 3273 QSGTRHAETSSGGQAASSHEQ--ARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDS 3330
Query: 184 K------MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQL 237
+ Q +D E + SD + + + + A D + Q+
Sbjct: 3331 RHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQV 3390
Query: 238 SDEEKMQNSDDE------RPQASDEEH-----RHSDDEEEQD----HKSESAR---GSDS 279
S E+ +++ R Q S E RHS +E QD H S R GS
Sbjct: 3391 STHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHY 3450
Query: 280 EDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
E V R + S + + ++ + SG+
Sbjct: 3451 EQSVDRSGHSGSHHSHTTSQGRSDASRGQSGS 3482
Score = 45.4 bits (106), Expect = 2e-04
Identities = 63/334 (18%), Positives = 116/334 (34%), Gaps = 39/334 (11%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
GS + S R D SG S ++ S + + +++D SGQ + ++
Sbjct: 3481 GSRSASRQTRNDEQSGDGS----RHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQG 3536
Query: 69 EGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE----GHRSD 124
S S S HSE S+ S ++ R+ D GS P ++ GH ++
Sbjct: 3537 SSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRD---GSRHPTSHHEDRAGHGHSAE 3593
Query: 125 ----GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERA-----QGSDEDK 175
G+HH+E +A S E+ R ++ Q++D + Q S +
Sbjct: 3594 SSRQSGTHHAENSSGGQAASSHEQ-ARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVR 3652
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQP 235
Q +D E + SD + + + + +
Sbjct: 3653 DSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLY 3712
Query: 236 QLSDEEKMQNS-----------DDERPQASDEEHRHSDDEEEQD-------HKSESARGS 277
Q+S E+ +++ R + + + RHS +E QD + +GS
Sbjct: 3713 QVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGS 3772
Query: 278 DSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGT 311
E V R + S + + ++ SG+
Sbjct: 3773 YHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGS 3806
Score = 45.1 bits (105), Expect = 2e-04
Identities = 65/323 (20%), Positives = 112/323 (34%), Gaps = 62/323 (19%)
Query: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDER---GDSGQPSNKELFGDD 65
G +S +E+K+ S + ++E + N+S E ++ E GD+ + ++ L +
Sbjct: 149 GKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKE 208
Query: 66 SEDEG--------------------ASHHSGSDNHSERSDN---------RSEASE---- 92
+EG A++++ D + +D+ RS +S+
Sbjct: 209 DNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSS 268
Query: 93 ----RSDHEDN-----DPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSE--KAHSD 141
RS HE+ S + GS D + EGH D H A + A
Sbjct: 269 SQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQ 328
Query: 142 DEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDER 201
R +S D +S D R G+ ++++ + Q E+ + S ER
Sbjct: 329 SRDGSRHPRSHDEDRASHGHSADSSRQSGT-----RHAETSSRGQTASSHEQARSSPGER 383
Query: 202 ----QQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEE 257
Q S + +S R AS ++ + E +NSD +
Sbjct: 384 HGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSG---- 439
Query: 258 HRHSDDEEEQDHKSESARGSDSE 280
H Q ES RG E
Sbjct: 440 --HGKAGLRQQSHQESTRGRSGE 460
Score = 38.9 bits (89), Expect = 0.015
Identities = 41/176 (23%), Positives = 67/176 (38%), Gaps = 21/176 (11%)
Query: 12 ADSEAERKDSDSGSDSDSDQENAASGSNASGS-------ESDQDERGDSGQPSNKELFGD 64
+D+ + S S S ++E + GS SGS ++D SGQ +
Sbjct: 3797 SDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRS 3856
Query: 65 DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDN--DPSDVDQHSGS---EAPNDDEDE 119
+ S S S+ + E S+ RSE++ R+ H + D +H GS + + +
Sbjct: 3857 RRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSS 3916
Query: 120 GHRSDGGS-----HHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQG 170
+SD + H S HS + G S S S+ ER +G
Sbjct: 3917 PVQSDSSTAKEHGHFSSLSQDSAYHSGIQSRG----SPHSSSSYHYQSEGTERQKG 3968
Score = 35.0 bits (79), Expect = 0.22
Identities = 45/273 (16%), Positives = 98/273 (35%), Gaps = 16/273 (5%)
Query: 87 RSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWG 146
R E S H+ S D+H ++ + E+ S ++ ++ S E G
Sbjct: 90 RKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGG 149
Query: 147 REDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSE 206
+ +S E+ S + + + K +NT D R++LSE
Sbjct: 150 KRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENT-------RLGDNRKRLSE 202
Query: 207 EEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEE 266
+ D+E V + + + ++ +Q+ + + EE++ +
Sbjct: 203 RLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRS 262
Query: 267 QDHKSES----ARGSDS-----EDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGG 317
D KS S +R ++ ++ R +R + ++ D +++ +E + +SG+
Sbjct: 263 SDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHH 322
Query: 318 ADDISSGSDGEDKPPTPGQPVDENGLPQDQQEE 350
DG P + + +G D +
Sbjct: 323 GSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQ 355
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 69.7 bits (169), Expect = 8e-12
Identities = 62/287 (21%), Positives = 115/287 (40%), Gaps = 30/287 (10%)
Query: 55 QPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPN 114
+P + GD ++ D SER +R A + DP V P
Sbjct: 968 EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL 1027
Query: 115 DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQ-SDDEKIQNSDDEERAQGSDE 173
+ + G + S E E +E+ +E+ ED D SDD +DDE+ A
Sbjct: 1028 ELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEAS 1087
Query: 174 DKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE---KQNSD 230
+K + D+E+ + + S E + SE E +S + P +S++++E ++ +
Sbjct: 1088 EKDEGDSDEEETVSIVTSKAEATSSSESSESSEFE--SSSESSPSSSEDEEEVVAREEEE 1145
Query: 231 DEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKN 290
+EE+ ++ EE M ++ E D E+ ++ A G+ + D
Sbjct: 1146 EEEEEEMVAEESMASAGPE-------------DFEQDGEEAALAPGAPAVD--------- 1183
Query: 291 AIASDSEADSDTE--VPKDNSGTMDLFGGADDISSGSDGEDKPPTPG 335
++ + E D +TE P++ +D + +D + P PG
Sbjct: 1184 SLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPG 1230
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/348 (21%), Positives = 124/348 (35%), Gaps = 50/348 (14%)
Query: 5 EDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGD-SGQPSNKELFG 63
E+ + + + + DSD +S++D E+ A + E D DE S S E
Sbjct: 1052 EEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATS 1111
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDV--DQHSGSEAPNDDEDEGH 121
E + S S++ S++ E R + E+ + ++ ++ S P D E +G
Sbjct: 1112 SSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGE 1171
Query: 122 RSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD 181
+ + A G+ S G E++ D + EER DE L
Sbjct: 1172 EA------ALAPGAPAVDS----LGMEEEVDIETEAVA----PEERPSMLDEPPLP-VGV 1216
Query: 182 DEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEE 241
+E + + E P LS + LS E A + RP S + + + E +P +
Sbjct: 1217 EEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPL 1276
Query: 242 KMQ-----------NSDDERPQASDEEHRHSDDEE-EQDHKSESARGSDSEDEVLRMKRK 289
+Q S P+ +D H E +DH +
Sbjct: 1277 PLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHT---------------P 1321
Query: 290 NAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQP 337
S +++ S VP G L GG+ +S S P PG P
Sbjct: 1322 GLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSS-----PQVPGSP 1364
Score = 53.9 bits (128), Expect = 5e-07
Identities = 58/269 (21%), Positives = 100/269 (37%), Gaps = 28/269 (10%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEG 70
D +SE ER D D + G + E G+ KE ++ E
Sbjct: 991 DEESERER-DRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQEST- 1048
Query: 71 ASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE----------- 119
+ E D+ ++ +R + E ND D SE D DE
Sbjct: 1049 EEEEEAEEEEEEEDDDDDDSDDRDESE-NDDEDTALSEASEKDEGDSDEEETVSIVTSKA 1107
Query: 120 -----GHRSDGGSHHSEAEGSEKAHSDDEK-WGREDKSDQSDDEKIQNSDDEERAQGSDE 173
S+ S +E S + D+E+ RE++ ++ ++E + +E A E
Sbjct: 1108 EATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVA---EESMASAGPE 1164
Query: 174 DKLQNSDDDEKMQN---TDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
D Q+ ++ D + D E + ++ EE+ + DE P+ ++ + +
Sbjct: 1165 DFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSRE 1224
Query: 231 DEEQPQLSDEEKMQNSDDERPQASDEEHR 259
E+P LS E M S + P A + E R
Sbjct: 1225 PPEEPGLSQEGAMLLSPE--PPAKEVEAR 1251
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/201 (21%), Positives = 78/201 (38%), Gaps = 21/201 (10%)
Query: 175 KLQNSDDDEKMQNTDDEE-RPQLSDDERQQLSEEEKANSDDERPVASDNDDEK------Q 227
K++ + + + D + RP S DE + SE E+ + P D K +
Sbjct: 963 KVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRR 1022
Query: 228 NSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMK 287
+ E +E++ ++ +E+ +EE ++EEE D + SD DE
Sbjct: 1023 PARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDD----SDDRDESENDD 1078
Query: 288 RKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED-------KPPTPGQPVDE 340
A++ SE D E D T+ + + +S S+ + +P DE
Sbjct: 1079 EDTALSEASEKD---EGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDE 1135
Query: 341 NGLPQDQQEEEPIPETRIEVE 361
+ ++EEE E + E
Sbjct: 1136 EEVVAREEEEEEEEEEMVAEE 1156
Score = 40.0 bits (92), Expect = 0.007
Identities = 34/100 (34%), Positives = 47/100 (47%), Gaps = 14/100 (14%)
Query: 573 DRYDEEEEGEESISLA-----AIKNRYKG-GIREERARIYSSDSDEGSEEDKAQRLLKAK 626
D DEE E E +A K KG G+R AR DS G EED+ + L + +
Sbjct: 988 DEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDS--GGEEDEKESLSEEQ 1045
Query: 627 KLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
+ T +EE E + + EDDD + + DE E DD+
Sbjct: 1046 ESTEEEE-EAEEEEEEEDDDDDDSDDR-----DESENDDE 1079
Score = 39.3 bits (90), Expect = 0.012
Identities = 48/213 (22%), Positives = 91/213 (42%), Gaps = 36/213 (16%)
Query: 476 GTGLQGQA---VFKTKLTFRPHSTDSATHRKMTLSLA----DRCSKTQKIRILP-----M 523
G GL+G FK K P +T S +++ S + D S+ ++ R + +
Sbjct: 950 GIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCEL 1009
Query: 524 AGRDPE--------CQRTEMIK--KEEERLRASIRRESQQRRMREKQHQRGLSASYLEPD 573
A RDP+ + E+ +E+E+ S +ES + ++ + + D
Sbjct: 1010 AKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSD 1069
Query: 574 RYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEE 633
DE E +E +L+ + +G DSDE EE + KA+ +S E
Sbjct: 1070 DRDESENDDEDTALSEASEKDEG------------DSDE--EETVSIVTSKAEATSSSES 1115
Query: 634 GEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
E S + + ++ + ++ V++ EEEE+++
Sbjct: 1116 SESSEFESSSESSPSSSEDEEEVVAREEEEEEE 1148
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 68.9 bits (167), Expect = 1e-11
Identities = 67/327 (20%), Positives = 133/327 (40%), Gaps = 31/327 (9%)
Query: 14 SEAERKDSDSGSDSDSD----QENAASGSNASGSESDQDERGDSGQPSNKE--LFGDDSE 67
S+ ++KDS + ++++ + N S + +D S N + + S+
Sbjct: 196 SQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSD 255
Query: 68 DEGASHHSGSDNHSE--------------RSDNRSEASERSDHEDNDPSDVDQHSGSEAP 113
DE + + N+S+ + D + A + SD E D D + S
Sbjct: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKK 315
Query: 114 N---DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSD--QSDDEKIQNSDDEERA 168
N DD+ + + D S +E+ S+ D +K ++ K D + D +K S D E
Sbjct: 316 NVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTE-- 373
Query: 169 QGSDEDKLQNSDDDEKMQNTDDEERPQ----LSDDERQQLSEEEKANSDDERPVASDNDD 224
G +D +S + +K DD+++ S D +L +E + + S D+
Sbjct: 374 SGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDN 433
Query: 225 EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVL 284
+K +DEE E K + ++ + ++ DD+++ K+ + +S+ E+
Sbjct: 434 KKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELK 493
Query: 285 RMKRKNAIASDSEADSDTEVPKDNSGT 311
+ K+ + S+ D + KD T
Sbjct: 494 KDKKHSKEKKGSKKDIKKDARKDTEST 520
Score = 57.0 bits (136), Expect = 5e-08
Identities = 58/311 (18%), Positives = 128/311 (41%), Gaps = 14/311 (4%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKEL 61
A+ ED + DS+ +K+ D D + ++A +S +DER D+ + K+L
Sbjct: 298 AESEDSKDAKKDSKKVKKNVKK-DDKKKDVKKDTESTDAESGDS-KDERKDT-KKDKKKL 354
Query: 62 FGDDSEDEGASHHSGSDNHS-----ERSDNRS-EASERSDHEDNDPSDVDQHSGSEAPND 115
DD + + + +D S R+D+R+ + + ++D + D + + SE+ +
Sbjct: 355 KKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELE 414
Query: 116 DEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK 175
+ E + + ++K+ +DE+ D + D +K + + + + +DK
Sbjct: 415 SK-ESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK 473
Query: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQP 235
D + ++T+ E +L D++ E++ + D ++ D + D+ +
Sbjct: 474 --KKDAKKNAESTEMESDLELKKDKKHS-KEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
Query: 236 QLSDEEKMQNSDDERPQASDEE-HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS 294
K++ SD E ++ + + DE + + G +S+ +K
Sbjct: 531 GFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNE 590
Query: 295 DSEADSDTEVP 305
E S VP
Sbjct: 591 KGEKASTGRVP 601
Score = 56.6 bits (135), Expect = 7e-08
Identities = 78/378 (20%), Positives = 151/378 (39%), Gaps = 43/378 (11%)
Query: 31 QENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED-----EGASHHSGSDNHSERSD 85
++NA S+A SE +D + DS + D +D E SG D+ ER D
Sbjct: 289 KKNAKKSSDAE-SEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESG-DSKDERKD 346
Query: 86 NRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKW 145
+ + + +D+ D ++ S + + R+D + ++ +K D +K
Sbjct: 347 TKKDKKKLK--KDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKK-KDAKKI 403
Query: 146 GREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLS 205
S+ + K D+++ + S D ++ +DE+ + D E + ++ +
Sbjct: 404 TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
Query: 206 EEEKANSDDERPVASDNDDEKQNSDD---EEQPQLSDEEKMQNSDDERPQASDEEHRHSD 262
++ + DD++ A N + + D ++ + S E+K D ++ D E ++
Sbjct: 464 GKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAE 523
Query: 263 DEEEQD---HKSESARGSDSEDEVLRMK---RKNAIASD-SEADSDTEVPKDNSGTMDLF 315
+E S +GSD+E E K +K SD + A+S E + G F
Sbjct: 524 FDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRG----F 579
Query: 316 GGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYF 375
+ ++ ++ +K T G +E+ P+P + PKV L +
Sbjct: 580 RMSSKKTTFNEKGEKAST--------GRVPPSREKPPLPACEPSLPSPKVRR-----LCW 626
Query: 376 VKLPNFLSVEPRPFDPQY 393
K+P P P P+Y
Sbjct: 627 CKMP------PPPPKPRY 638
Score = 37.7 bits (86), Expect = 0.034
Identities = 35/161 (21%), Positives = 75/161 (46%), Gaps = 31/161 (19%)
Query: 527 DPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESIS 586
D E + ++ KK+ ++++ +++++ +++ +++ + + +R D +++
Sbjct: 297 DAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKD------ 350
Query: 587 LAAIKNRYKGGIREERARIY--SSDSDEGSEEDKAQ--RLLK-----------AKKLT-- 629
K + K +++ + Y S+D++ G +D R LK AKK+T
Sbjct: 351 ----KKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFS 406
Query: 630 SDEEGEPSGKRKAEDDDKANKK----HKKYVISDEEEEDDD 666
+D E E K +D+ K K +KK V +DEE D D
Sbjct: 407 TDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDAD 447
Score = 32.0 bits (71), Expect = 1.9
Identities = 22/129 (17%), Positives = 54/129 (41%), Gaps = 10/129 (7%)
Query: 536 IKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYK 595
+KK++++ ES + + R S + + + D++++ + I+ +
Sbjct: 354 LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFST------ 407
Query: 596 GGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKY 655
+ + + S +S + ++DK KK ++E + + D K KK +K
Sbjct: 408 ----DSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKK 463
Query: 656 VISDEEEED 664
D +++D
Sbjct: 464 GKKDSKKDD 472
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.6 bits (166), Expect = 2e-11
Identities = 104/553 (18%), Positives = 223/553 (40%), Gaps = 46/553 (8%)
Query: 116 DEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKI--QNSDDEERAQG-SD 172
+E+ G R E E +E +++ E + Q DE++ Q + +ER + ++
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 173 EDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDE 232
E++LQ+ E + D+E+ + E ++ EEK ER ++E++
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 233 EQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAI 292
E +EEK+Q + +R + EE E Q+ + E + + + + LR +++
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE-RQEEEQQQQRLRREQQLRR 308
Query: 293 ASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEP 352
+ E E ++ + + + E++ E L ++Q+EE
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEER--------REQQLRREQEEERR 360
Query: 353 IPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRL 412
+ R E E + L + + + R E + E+ L E + R
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRR-----EQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 413 KLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLF 472
+ ++ + R ++EE +E K R + + + + +
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQ------------------RLKREQEERRDW 457
Query: 473 IRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQR 532
+++ + + K + + R + L +R + Q+ R R+ E +R
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER--REQQERREQQLRREQEERR 515
Query: 533 TEMIKK--EEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAI 590
+ +K+ EEERL+ +R E Q RR +E++ ++ L E ++ E+E E+ +
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR---EEEKRLEQERREQRLKREQE 572
Query: 591 KNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANK 650
+ R + REE R ++ ++ + + ++L +E E KR+ ++++ +
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 651 KHKKYVISDEEEE 663
K S+E+EE
Sbjct: 633 LLK----SEEQEE 641
Score = 68.6 bits (166), Expect = 2e-11
Identities = 130/668 (19%), Positives = 250/668 (37%), Gaps = 96/668 (14%)
Query: 19 KDSDSGSDS----DSDQENAASGSNA--SGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
+D D SD + ++ENA + G E++Q + + Q D +
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ------LRDRQSQQDLQ 1268
Query: 73 HHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHS-- 130
H G +R R +R H + + +++ E R D S
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEE---------EQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 131 ----EAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQ 186
E E + D K+ E++ Q +E Q +ER + E++L++ + K
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFREEELRHQEQGRKF- 1376
Query: 187 NTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNS 246
++E+R + + ER+ L EE++ + + D K EE+ QLS +E+ +
Sbjct: 1377 -LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR---EEEQQLSRQERDRKF 1432
Query: 247 DDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPK 306
+E Q +E EEEQ + E R E+++L+ + + + + D +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL---HRQERDRKFL- 1488
Query: 307 DNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVN 366
E++ Q D Q+ + +E PE + E +++
Sbjct: 1489 ---------------------EEEQQLRRQERDRKFREQELRSQE--PERKFLEEEQQLH 1525
Query: 367 TDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWR--- 423
+ + E Q + +F +EE L +E + + E ++R
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 424 --IRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQG 481
+RR E+ + E ++ + +G L + + D L R+ L
Sbjct: 1586 QKVRRQEQERKFMEDEQQL-RRQEGQQQLRQERD------RKFREDEQLLQEREEQQLHR 1638
Query: 482 QAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEE 541
Q + L P +++ DR K ++ L G + + +R E +K E
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLR---HDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 542 RLRASIRRESQQRRMREKQHQR--GLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIR 599
+ R+E +++ ++E+Q R L + E ++ +E E E+ + RY+ +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ----LRRQERYRKILE 1751
Query: 600 EERARIYSSDSDEGSEEDKAQRLLKAKKLTSDE----EGEPSGKRKAEDDDKANKKHKKY 655
EE+ R EE + +R + +K +E E E R E D K ++ +
Sbjct: 1752 EEQLR-------PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ-- 1802
Query: 656 VISDEEEE 663
+ E EE
Sbjct: 1803 -LRQEREE 1809
Score = 62.8 bits (151), Expect = 1e-09
Identities = 115/642 (17%), Positives = 250/642 (38%), Gaps = 71/642 (11%)
Query: 82 ERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDE-----DEGHRSDGGSHHSEAEGSE 136
E+ R A + + ED D ++ E D + +E + + +++ E
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 137 KAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD----DEKMQNTDDEE 192
+ + + E++ Q ++ + + ++ER Q +E++LQ ++ +E+ + E
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQER-QYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDND----DEKQNSDDEEQPQLSDEEKMQNSDD 248
Q D++ Q EE+ + E+ + + +E++ +EEQ + EK + +
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 249 ERPQASDEEHRHSDD----EEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEV 304
ER +E + ++ EE + + + E+E L+ + + + + E E+
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 305 PKDNSGTMDLFGGADDI-SSGSDGEDKPPTPGQPVDENGLPQDQQE---EEPIPETRIEV 360
+ +L + + + + Q +E L Q++++ EE R E+
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 420
E + + L EP Q E ++ +EE L +E L+ + E
Sbjct: 1137 ERQYREEEEVQQ----EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 421 RWRIRRDEEGNEIKESNAR------------IVKWSDGSMSLHLGNEVF----------- 457
+ R R+ E E++ + +W + N+V+
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 458 ----DVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCS 513
+ Q D HL Q + Q + + R + R+ R
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 514 KTQKIRILPMAGRDPECQRTEMIKK--EEERL-----RASIRRESQQRRMREKQ--HQRG 564
K+Q+ + L R+ + +R E +K EEE+L +RR+ + R+ RE++ HQ
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE- 1371
Query: 565 LSASYLEPDRYDEEEEGEESISLAAIKNR---YKGGIREERARIYSSDSDEGSEEDKAQR 621
+LE ++ +E E + R + +R++R R + + + S +++ ++
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 622 LLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEE 663
+ ++ +E E K E+ ++H+K+ EEE+
Sbjct: 1432 FREEEQQVRRQERE--RKFLEEEQQLRQERHRKF---REEEQ 1468
Score = 61.6 bits (148), Expect = 2e-09
Identities = 114/663 (17%), Positives = 246/663 (37%), Gaps = 64/663 (9%)
Query: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
+ ER++ + ++ + E Q + Q ++ + E+E
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
++ ER + E+ + S + + + E + +S S + EG
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL---ESEADARQSKVYSRPRKQEG 728
Query: 135 SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERP 194
+ +EK R + Q +E+ + +E Q D +++ + RP
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 195 QLSDDERQQLSEEEKANSDD---------ERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
L + +QL EE+ + E+ + EK+ EE+ QL E+ Q
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 246 SDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVP 305
+E +++ R E+ +D K E+E R +R++ + + ++
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWR----WQLEEE--RKRRRHTLYAKPALQE--QLR 900
Query: 306 KDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKV 365
K+ L ++ + E + + Q+EE+ + E R + +
Sbjct: 901 KE----QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 366 NTDLGNDLYF-VKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIR--W 422
D K L EP Q E ++ +EE L +E L+ + E R W
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 423 RIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQ 482
R+ + +E+++ ++++ L + + LQ + L G + +
Sbjct: 1017 E-RQYRKKDELQQEEEQLLREEREKRRLQERERQYR-EEEELQQEEEQLL-----GEERE 1069
Query: 483 AVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEER 542
+ +L R + + ++ L + K ++ R+ +C+ E +++EEE+
Sbjct: 1070 TRRRQELE-RQYRKEEELQQEEEQLLREEPEKRRR------QERERQCREEEELQQEEEQ 1122
Query: 543 LRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREER 602
L +R E ++RR +E + Q Y E + +EEE ++ + R+E
Sbjct: 1123 L---LREEREKRRRQELERQ------YREEEEVQQEEE-------QLLREEPEKRRRQEL 1166
Query: 603 ARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEE 662
R Y + + EE++ R E+ +R+ ++++ ++ +K DE++
Sbjct: 1167 ERQYREEEELQQEEEQLLR-------EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 663 EDD 665
D
Sbjct: 1220 RSD 1222
Score = 61.6 bits (148), Expect = 2e-09
Identities = 126/690 (18%), Positives = 265/690 (38%), Gaps = 93/690 (13%)
Query: 3 DMEDLFGS--DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 60
D++ L G + D E ER+ ++E E + +R D K+
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER------EEQKEAKRRDRKSQEEKQ 1319
Query: 61 LFGDDSEDEGASHHSGSDNHSERS--DNRSEASERSDHEDNDPSDVDQHSGSEAPNDDED 118
L ++ E++ + E R E R D E+
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR--------------KFREE 1365
Query: 119 EGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQN 178
E + G E E + + K+ +E++ + + + Q D +R +E +L
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 179 SDDDEKMQNTDDEERPQLSD----DERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
+ D K + + + R Q + +E QQL +E +E + + ++++ + + ++
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 235 PQLSDEEKMQNSDDER-----PQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRK 289
L +E++++ + +R S E R +EE+Q H+ + R E++ LR + +
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Query: 290 NAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQE 349
D D + ++ + + S + + K Q V + Q++
Sbjct: 1546 ---GQQRRQDRDRKFREEEQLRQE---REEQQLSRQERDRKFRLEEQKV------RRQEQ 1593
Query: 350 EEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDE----FEDEEMLD 405
E E ++ + L + D ++ EDE +E+ L
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQER----------------DRKFREDEQLLQEREEQQLH 1637
Query: 406 EEGRTRLKLKVENTIRWRIR----RDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYK 461
+ R R L+ E +R + R R + + +E + + + + + F +
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 462 APL-QGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRI 520
L + + F+++ L+ Q + + FR + L +R K +
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQ---ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 521 LPMAGRDPECQRTEMIKK--EEERLR-----ASIRRESQQRRMREKQHQR-GLSASYLEP 572
L + + +R E +K EEE+LR +R + R+ RE++ R L P
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 573 DRYDEEEE-GEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSD 631
+ D + EE + L + R +R+ER R Y ++ ++ + ++K++R + ++L +
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQR----LRQERDRQYRAE-EQFATQEKSRR--EEQELWQE 1867
Query: 632 EEGEPSGKRKAEDDDKANKKHKKYVISDEE 661
EE KR+ E + K ++H + +E+
Sbjct: 1868 EE----QKRRQERERKLREEHIRRQQKEEQ 1893
Score = 60.8 bits (146), Expect = 4e-09
Identities = 109/648 (16%), Positives = 251/648 (38%), Gaps = 58/648 (8%)
Query: 44 ESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSD---NRSEASERSDH--ED 98
E R Q +EL + + E D + R E ER + E+
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190
Query: 99 NDPSDVDQHSGSEAPNDDEDEGH---------RSDGGSHHSEAEGSEKAHSDDEKWGRED 149
H E P++++ R + E + ++++W + +
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 150 KSDQSDDEKIQNSDDE-ERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQL---S 205
+ ++EK+Q + + +R +E++L+ + E + +EE+ Q QQL
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Query: 206 EEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEE 265
EEE+ +ER + +Q + EQ ++E+ + R Q + + E+
Sbjct: 311 EEERREQQEER--REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 266 EQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMD-LFGGADDISSG 324
E++ + + R +++R+ + + + + ++ ++ + +
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 325 SDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV---EIPKVNTDLGNDLYFVKLPNF 381
+ E Q E L ++Q+E + E E + L D + +
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 382 LSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLK-LKVENTIRWRIRRDEE-GNEIKESNAR 439
L +E Q E + +E RLK + E ++ R+R +++ E +E +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 440 IVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSA 499
++K + L E + Q + +++ + Q + + + +
Sbjct: 549 LLKREE---EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ--------EER 597
Query: 500 THRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKK---EEERLRASIRRESQQRR- 555
+++ +R + ++ R + +PE +R + + K +EER + +RRE Q+RR
Sbjct: 598 LEQRLKREEVERLEQEER-REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 556 ---MREKQHQR---GLSASYLEPDRYDEEEEGEESISLAAIKNR---YKGGIREE----R 602
RE++ +R L + E R E E E+ + IK+R ++ + E +
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 603 ARIYSSDSDEGSEEDKAQRLLKAKKLTSD---EEGEPSGKRKAEDDDK 647
+++YS + + + ++ K ++ S+ +E E + +++ E++ +
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Score = 60.1 bits (144), Expect = 6e-09
Identities = 106/569 (18%), Positives = 220/569 (38%), Gaps = 96/569 (16%)
Query: 111 EAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKS--DQSDDEKIQNSDDEERA 168
+A DE++ R DG + E+ D ++ D+ ++ + Q ++ER
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEE---DQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147
Query: 169 QGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQN 228
E++ S+ E+++ D + R + +RQ+ E E+ +++E + Q+
Sbjct: 148 LAEGEEQ---SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE---------QLQS 195
Query: 229 SDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKR 288
E + DEE++ R + E R +E++Q + R E+E KR
Sbjct: 196 CKGHETEEFPDEEQL------RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 289 KNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQ 348
+ + + E + E + ++ + K ++ L +++Q
Sbjct: 250 ETVLRKEEEKLQEEEPQRQR-----------ELQEEEEQLRK-------LERQELRRERQ 291
Query: 349 EEEPIPET-RIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEE 407
EEE + R E ++ + E R + ++ E E +E
Sbjct: 292 EEEQQQQRLRREQQLRRKQE-----------------EERREQQEERREQQERREQQEER 334
Query: 408 GRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGD 467
+L+ + E ++RR++E E +E R + + +
Sbjct: 335 REQQLRREQEERREQQLRREQE-EERREQQLRREQ----------------------EEE 371
Query: 468 HNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRD 527
+R+ L+ + + + R + R+ L + + Q++R R+
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLR---REQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 528 PECQRTEMIKKEEERLRASIRRESQQRR---MREKQHQRGLSASYLEPDRYDEEEEGEES 584
E +R E K E+ER ++RE ++RR RE++ +R + + D+EEE E
Sbjct: 429 QEEERHEQ-KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 585 -ISLAAIKNRYKGGIREERARIYSSDSDEG------SEEDKAQRLLKAKKLTSDEEGEPS 637
+ L + R + RE++ R + E EE QRL ++L ++E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 638 GKRKAEDDDKANKKHKKYVISDEEEEDDD 666
K E++ + ++ ++ + E+EE D
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRD 576
Score = 50.4 bits (119), Expect = 5e-06
Identities = 108/673 (16%), Positives = 257/673 (38%), Gaps = 44/673 (6%)
Query: 14 SEAERKDSDSGSDSDS--DQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGA 71
+E E+ S G +++ D+E ++E+ + +F ++ E E
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDP-SDVDQHSGSEAPNDDEDEGHRSDGGSHHS 130
+ E+ +R E+ + +++ ++E + R
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 131 EAEGSEKAHSDDEKWGREDKSDQSDDEKIQN--SDDEERAQGSDEDKLQNSDDDEKMQNT 188
+ E+ +E+ ++++ +Q ++ + Q + EER + + + +++++
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 189 DDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEE---QPQLSDEEKMQN 245
+EER + QQL E++ + + E+Q +++ + QL E++++
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 246 SDDER--PQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
+E Q ++E R + EQ+ + + + + + + +RK + D E +
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 304 VPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIP 363
K + E + + E L + ++EE R E ++
Sbjct: 488 WLK--------LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 364 KVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGR--TRLKLKVENTIR 421
+ + L + L E R + ++E D+ + EE R RLK + E +
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 422 WRIRRDE-EGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 480
R++R+E E E +E + +K + + K+ Q + +R+ +
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQ-----QLLKSEEQEERRQQQLRREQQER 654
Query: 481 GQAVFK-----TKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQ---R 532
+ K +L R R+ L+ ++ ++I+ R P+ Q
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK-----SRIPKWQWQLE 709
Query: 533 TEMIKKEEERLRASIRRESQQRR--MREKQHQRGLSASYLEPDRYDEEEEGEESISLAAI 590
+E ++ + ++E Q+RR EK+ +R + E +R +++ EE
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE--QRRDF 767
Query: 591 KNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANK 650
+++ + ER R S + E + ++L ++ ++ P + K + + +
Sbjct: 768 TWQWQAEEKSERGRQRLS-ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 651 KHKKYVISDEEEE 663
+ K+ +EEE+
Sbjct: 827 REKELQFLEEEEQ 839
Score = 49.7 bits (117), Expect = 9e-06
Identities = 108/603 (17%), Positives = 223/603 (36%), Gaps = 99/603 (16%)
Query: 82 ERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSD 141
E+ + R + +R + E+ + Q SE E E R E ++
Sbjct: 510 EQEERREQRLKRQEEEER----LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 142 DEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDER 201
K +E++ DQ K + ++R + E++L+ E+++ + EER +
Sbjct: 566 RLKREQEERRDQL--LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE------ 617
Query: 202 QQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHS 261
Q+L EE ++ + S+ +E++ + Q E++++ ++E + H
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 262 DDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS-----DSEADSDTEVPKDNSGTMDLFG 316
++ EQ+ E E E R + K+ I +SEAD+ +
Sbjct: 678 EERREQELAEE-------EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE--- 727
Query: 317 GADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFV 376
G + + + Q +E + QQEEE + + + + ++ G
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE-KSERGRQRLSA 786
Query: 377 KLPNFLSVEP--RPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIK 434
+ P E R + Q E F EE EE R + + E + +EE + +
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQLQRR 843
Query: 435 ESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPH 494
E ++ + DG LQ D R
Sbjct: 844 ERAQQLQEEEDG-----------------LQEDQE----------------------RRR 864
Query: 495 STDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQR 554
S + +K L + + + A ++ + +++++EEE L+ R + +R
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK--RR 922
Query: 555 RMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSD--- 611
R +++ Y E ++ +EEE ++ + R+ER R Y D
Sbjct: 923 RQEQER-------QYREEEQLQQEEE-------QLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 612 -----EGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKK---HKKYVISDEEEE 663
G E +K +R + KK +EE + ++ ++ + ++ ++Y DE ++
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 664 DDD 666
+++
Sbjct: 1029 EEE 1031
Score = 49.3 bits (116), Expect = 1e-05
Identities = 101/631 (16%), Positives = 242/631 (38%), Gaps = 97/631 (15%)
Query: 55 QPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPN 114
Q ++L ++ E E E R + E ++++ E
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 115 DDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDED 174
E+E + E ++ + E+ RE++ Q ++E++ + E+R Q +
Sbjct: 1147 QQEEEQLLRE--------EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ----E 1194
Query: 175 KLQNSDDDEKMQNTDDEERPQLSDDERQQLS---EEEKANSDDERPVASDNDDEKQNSDD 231
+ + ++E++Q ++R + +D+R L E EK N+ DN + ++
Sbjct: 1195 RERQYREEEELQRQKRKQRYR-DEDQRSDLKWQWEPEKENA------VRDNKVYCKGREN 1247
Query: 232 EEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNA 291
E+ QL D + + Q E + D E+E+ + R E+++ R ++K A
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 292 IASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEE 351
D ++ + ++ ++ E + Q D + +EEE
Sbjct: 1308 KRRDRKSQEEKQLLRE--------------------EREEKRRRQETD-----RKFREEE 1342
Query: 352 PIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTR 411
+ + R E + + D R F + + + + L+EE R R
Sbjct: 1343 QLLQEREEQPLRRQERD------------------RKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 412 LKLKVENTIR--WRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVF-DVYKAPLQGDH 468
+ + ++ ++R E ++++ R + + +S + F + + + +
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQER 1444
Query: 469 NHLFIRQGTGLQGQ--AVFKTKLTFRPHSTDSATHRK-------MTLSLADRCSKTQKIR 519
F+ + L+ + F+ + + HR+ R + +K R
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504
Query: 520 ILPMAGRDPECQ--RTEMIKKEEERLRASIRRESQQRRM-REKQHQRGLSASYLEPDRYD 576
+ ++PE + E ++R R ++ E Q RR R +Q ++ + E ++
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564
Query: 577 EEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEP 636
+E E E+ +S R+ER R + + + +++ ++ ++ ++ +EG+
Sbjct: 1565 QERE-EQQLS------------RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 637 SGK----RKAEDDDKANKKHKKYVISDEEEE 663
+ RK +D++ ++ ++ + +E +
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Score = 46.6 bits (109), Expect = 7e-05
Identities = 31/138 (22%), Positives = 66/138 (47%), Gaps = 10/138 (7%)
Query: 142 DEKWGREDKSDQS--DDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD- 198
+E+ R + D+ ++E+++ +E++ + + D+ ++ + + + + RPQ D
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 199 -----DERQQLSEEE-KANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+E+ QL E+E + + +R ++ Q E+ +L EE+ Q ER +
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEE-QKRRQERER 1878
Query: 253 ASDEEHRHSDDEEEQDHK 270
EEH +EEQ H+
Sbjct: 1879 KLREEHIRRQQKEEQRHR 1896
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 67.0 bits (162), Expect = 5e-11
Identities = 79/399 (19%), Positives = 146/399 (36%), Gaps = 54/399 (13%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAAS-GSNASGSESDQDE-RGDSGQPSNKELFGD---- 64
DA +R+ D+ D+ E + S G N ES + E R +S S E+ D
Sbjct: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
Query: 65 --------------DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSD------V 104
S HS + N+ + + RS ER + + D D
Sbjct: 563 SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSF 622
Query: 105 DQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSD- 163
++ G D+ + R H + E + + R D+ D DE+ + D
Sbjct: 623 ERRHGERDRRDNRERDQRPSSPIRH-QGRNDELERDERREERRVDRVDDRRDERARERDR 681
Query: 164 ----------------DEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
D ER + + ++ + + + + + D ER + D +R++ E
Sbjct: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
Query: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHR---HSDDE 264
E+ + + + E++ + E+ + + E+ + D ER + D E + D
Sbjct: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
Query: 265 EEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSG 324
E+++ E D DE KR S S S +++S D + DD +
Sbjct: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR-RREHSPDSDAYNSGDDKNEK 860
Query: 325 SD--GEDKPPTPGQPVDENGLPQDQQ----EEEPIPETR 357
+ P + + + L +D+Q EE+ PE +
Sbjct: 861 HRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK 899
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/352 (19%), Positives = 138/352 (39%), Gaps = 25/352 (7%)
Query: 17 ERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNK--ELFGDDSEDEGASHH 74
+ +DS D D + + ++ + D R G+ +++ + + ++S G +H
Sbjct: 475 DMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHL 534
Query: 75 SGSDNHSE---RSDNRSEASERSDHEDNDPSDVDQ--HSGSEAPNDDEDEGHRSDGGSHH 129
+ +E S N S + R+D V + GS + + H S+ H
Sbjct: 535 REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHD 594
Query: 130 SEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTD 189
S S ++ + +++ D DQ+ D + E R + + ++ Q + Q +
Sbjct: 595 SWETRS--SYPERDRYPERDNRDQARDSSFERRHGE-RDRRDNRERDQRPSSPIRHQGRN 651
Query: 190 DEERPQLSDDERQQLSEEEKANS-DDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD 248
DE L DER++ ++ + DER D + E+ + E+ + D E+ + +
Sbjct: 652 DE----LERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKEREL 707
Query: 249 ERPQASDEEH-------RHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSD 301
ER +A + E R D + + D + E R D E E R + + + E + +
Sbjct: 708 ERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERE 767
Query: 302 TEVPKDNSGTMDLFGGAD---DISSGSDGEDKPPTPGQPVDENGLPQDQQEE 350
E ++ + + D G D + + E+ P+D +E
Sbjct: 768 RERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDE 819
Score = 56.2 bits (134), Expect = 9e-08
Identities = 129/663 (19%), Positives = 224/663 (33%), Gaps = 70/663 (10%)
Query: 28 DSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNR 87
D +E G + Q E+ D +P + G + HHS S
Sbjct: 288 DRIEEKTRDGKDRGRDFERQREKRD--KPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRH 345
Query: 88 SEASER----SDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDE 143
S + R S + + S S P+ R H + EK D E
Sbjct: 346 SPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRH-RSPMREKGRHDHE 404
Query: 144 KWGREDKSDQSDDEKIQNSDD----EERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDD 199
+ + QS D + + +D +R + S E++ D + DD E P+ D
Sbjct: 405 R------TSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDRE-PRDGRD 457
Query: 200 ERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHR 259
R ++ D R + + + D +E D +++ D R + + HR
Sbjct: 458 RRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHR 517
Query: 260 HSD--DEEEQDHKSESARGSDSEDEV---LRMKRKNAIASDSEADSDTEVPK-DNSGTMD 313
D EE + + R S E+ R + ++ I +D S VP+ G+
Sbjct: 518 KEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRG 577
Query: 314 LFGG-ADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGND 372
G D SS S+ D T + + P+ ++ + E D ++
Sbjct: 578 SRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSS---FERRHGERDRRDN 634
Query: 373 LYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNE 432
+ P+ P Q DE E +E +E R+ + + R R R E E
Sbjct: 635 RERDQRPS------SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRE 688
Query: 433 IKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFR 492
+ R + + + R+ + + K + R
Sbjct: 689 RERERER---------------------ERDREREKERELERERAREREREREKERDRER 727
Query: 493 PHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQ 552
D R+ DR + ++ R R+ E +R ++E ER R + +
Sbjct: 728 DRDRDHDRERERERE-RDREKEREREREERERERERERERERERERERERARERDKERER 786
Query: 553 QRRMREKQHQRGLSASYLEPDRYDE--EEEGEESISLAAIKNRYKGGIRE--ERARIYSS 608
QR +K R E R D + +E S +N R+ +R R +S
Sbjct: 787 QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
Query: 609 DSD---EGSEEDKAQRLL-------KAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVIS 658
DSD G ++++ RLL +++ L+ E R E+D K +K
Sbjct: 847 DSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
Query: 659 DEE 661
++E
Sbjct: 907 EQE 909
Score = 55.8 bits (133), Expect = 1e-07
Identities = 75/352 (21%), Positives = 123/352 (34%), Gaps = 37/352 (10%)
Query: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
DS ER+ + + +++ S +D+ ER + + + DD DE A
Sbjct: 619 DSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRV-DDRRDERAR 677
Query: 73 HHSGSDNHSERSDNRSEASERS-DHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSE 131
D ER R ER D E ++++ E + E E R +
Sbjct: 678 ER---DRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734
Query: 132 AEGSEKAHSDDEKWGREDKSDQSDD---------------EKIQNSDDEERAQGSDEDKL 176
E + D EK ++ ++ + E+ + D E Q EDK
Sbjct: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKD 794
Query: 177 QNSDDD-EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQP 235
+ DD EK + ++ P+ DER+ S R + +SD
Sbjct: 795 KGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSG 854
Query: 236 QLSDEEKMQNSDDERPQAS---DEEHRHSDDE---EEQDHKSESARGSDSEDEVLRMKRK 289
+E+ S RPQ S H D + +E+D K E S +E + K
Sbjct: 855 DDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE---QELK 911
Query: 290 NAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDEN 341
++S + TE+ + + A DI ED+ T + DEN
Sbjct: 912 EKVSSVDKQREQTEILESSRMR------AQDIIGHHQSEDR-ETSDRAHDEN 956
Score = 55.1 bits (131), Expect = 2e-07
Identities = 64/324 (19%), Positives = 126/324 (38%), Gaps = 31/324 (9%)
Query: 13 DSEAER-KDSDSGSDSDSDQENAASGSNASGSE--SDQDERGDSGQPSNKELFGDDSEDE 69
D+ +R ++ DS + + +Q+ ++S + E +D R +EL +
Sbjct: 419 DTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRD 478
Query: 70 GASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSH- 128
S + E D R S R H+ D D H D E RS G +H
Sbjct: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH----RKEDTYPEESRSYGRNHL 534
Query: 129 ---------HSEAEGSEKAHSDDEKWGR---------EDKSDQSDDEKIQNSDDEERAQG 170
+E+ ++ +++ GR E S S +I +
Sbjct: 535 REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHD 594
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSD-DERPVASDNDDEKQNS 229
S E + + D + D+ ++ + S ER+ + + N + D+RP S + +
Sbjct: 595 SWETRSSYPERD-RYPERDNRDQARDSSFERRHGERDRRDNRERDQRP--SSPIRHQGRN 651
Query: 230 DDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRK 289
D+ E+ + +E ++ DD R + + E R + + E++ + E R + E E ++R+
Sbjct: 652 DELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKE-RELERE 710
Query: 290 NAIASDSEADSDTEVPKDNSGTMD 313
A + E + + + +D D
Sbjct: 711 RAREREREREKERDRERDRDRDHD 734
Score = 52.4 bits (124), Expect = 1e-06
Identities = 82/336 (24%), Positives = 126/336 (37%), Gaps = 38/336 (11%)
Query: 30 DQENAAS-GSNASGSESDQDERGDSGQPSNKELF--GDDSEDEGASHHSGSDNHSERSDN 86
DQ+ ++S GSN S G PSN GDD HSGS + E++ +
Sbjct: 1185 DQKRSSSLGSNRSNRSHTS---GRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR-EKTKS 1240
Query: 87 RSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWG 146
ER S +DQ E + R D SH S E SD +
Sbjct: 1241 LEITGERK-------SRIDQLKRGEPSRSTSSD--RQDSRSHSSRRSSPE---SDRQVHS 1288
Query: 147 REDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSE 206
R D D ++Q D E D ++ + D + + D ++ + +R +L E
Sbjct: 1289 RSGSFDSRD--RLQERDRYEH----DRERERERRDTRQREWDRDADKDWPRNRDRDRLRE 1342
Query: 207 EEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEE 266
E+ D+R D + E+ SD E+ + D ++ S E + E +
Sbjct: 1343 RERERERDKRR-DLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
Query: 267 QDHKSESARGSDSE--DEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSG 324
+ S + D E D+ L + + SE E D S D A + SG
Sbjct: 1402 LESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDD----AHSLGSG 1457
Query: 325 SDGEDKPPTPGQPVDE-----NGLPQDQQEEEPIPE 355
+ GE P +DE +DQQ+EE +P+
Sbjct: 1458 A-GEGYEPISDDELDEILAGDAEKREDQQDEEKMPD 1492
Score = 50.8 bits (120), Expect = 4e-06
Identities = 72/313 (23%), Positives = 122/313 (38%), Gaps = 58/313 (18%)
Query: 17 ERKDSDSGSDSDSDQENAA---SGSNASGSESDQDERG----------DSGQPSNKELFG 63
+++ S GS+ + + S SN S S D+ G D + + E+ G
Sbjct: 1186 QKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITG 1245
Query: 64 DDSE--DEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGH 121
+ D+ S+R D+RS +S RS E SD HS S + D D
Sbjct: 1246 ERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPE----SDRQVHSRSGS-FDSRDRLQ 1300
Query: 122 RSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE---ERAQGSDEDKLQN 178
D H E E E+ + +W R+ +D + +N D + ER + + DK ++
Sbjct: 1301 ERDRYEHDRERE-RERRDTRQREWDRD-----ADKDWPRNRDRDRLRERERERERDKRRD 1354
Query: 179 SDDDEKMQNTDDEERPQLSDDERQQLSE--------EEKANSDDERPVASDNDD----EK 226
D + + +D ER + D +R S E K + ER + S + D +K
Sbjct: 1355 LDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDK 1414
Query: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRH-----------------SDDEEEQDH 269
+ D + EE ++ E +A D+E + SDDE ++
Sbjct: 1415 ERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEIL 1474
Query: 270 KSESARGSDSEDE 282
++ + D +DE
Sbjct: 1475 AGDAEKREDQQDE 1487
Score = 49.7 bits (117), Expect = 9e-06
Identities = 67/329 (20%), Positives = 123/329 (37%), Gaps = 49/329 (14%)
Query: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQD-------ERGDSGQPSNKELFG 63
+ + E ER++ + + + ++E E D++ E D G+ +E
Sbjct: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE 805
Query: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHS-GSEAPN--DDEDEG 120
+ ED D H ER + +E S P +HS S+A N DD++E
Sbjct: 806 EIREDRNPR-----DGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEK 860
Query: 121 HRS-DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEK-----IQNSDDEERAQGSDED 174
HR E+ +H +++ GR + D+ + K + + +E+ D+
Sbjct: 861 HRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQ 920
Query: 175 KLQN------------------SDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDER 216
+ Q S+D E DE + + ++ ++E +
Sbjct: 921 REQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERG 980
Query: 217 PVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARG 276
+ + ++D + S + Q + S E+K + S + SDEE +Q K R
Sbjct: 981 NIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD-SDISDEE------AAQQSKKKRGPRT 1033
Query: 277 ---SDSEDEVLRMKRKNAIASDSEADSDT 302
+ E+ V KN I DS+ DT
Sbjct: 1034 PPITTKEELVEMCNGKNGILEDSQKKEDT 1062
Score = 45.8 bits (107), Expect = 1e-04
Identities = 133/690 (19%), Positives = 226/690 (32%), Gaps = 79/690 (11%)
Query: 8 FGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSE 67
+ S + S +RK S S ++ S S + ER + + E
Sbjct: 374 YPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREE 433
Query: 68 DEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
E S S +H + + R R + D ++ + D +
Sbjct: 434 REYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESR 493
Query: 128 HHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQN 187
++ + AH ++ GR+ K +E R+ G + + + S E
Sbjct: 494 DPRDSRSTRDAHDYRDREGRD------THRKEDTYPEESRSYGRNHLR-EESSRTEIRNE 546
Query: 188 TDDEERPQLSDD----ERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKM 243
+ +E R ++ +D R ++ E + S R D+ N D + + S E+
Sbjct: 547 SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERD 606
Query: 244 QNSD-DERPQASDE--EHRHS-----DDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
+ + D R QA D E RH D+ E S R DE+ R +R+ D
Sbjct: 607 RYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVD 666
Query: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPE 355
D E ++ D D E + + E ++ + E
Sbjct: 667 RVDDRRDERARER-----------DRERERDRERERERERERDREREKERELERERARER 715
Query: 356 TRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLK 415
R + D D R + + D E E + E R R + +
Sbjct: 716 EREREKERDRERDRDRD------------HDRERERERERDR-EKEREREREERERERER 762
Query: 416 VENTIRWRIRRDEEGNEIKESNARIVKWSD---GSMSLHLGNEVFDVYKAPLQGDHNHLF 472
R R R E E + R W D G E + P G
Sbjct: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
Query: 473 IRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQR 532
++ + ++ R HS DS + K +K R+L R E +
Sbjct: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGD-------DKNEKHRLLSQVVRPQESRS 875
Query: 533 ---TEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAA 589
+ + + + R + R+ ++ R + Q L D+ E+ E ES + A
Sbjct: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQE-LKEKVSSVDKQREQTEILESSRMRA 934
Query: 590 --IKNRYKGGIREERARIYSSDSDEGSEEDKAQRL-LKAKK-----------LTSDEEGE 635
I ++ RE R + DE ++ K Q+ +K KK T+ E+G+
Sbjct: 935 QDIIGHHQSEDRETSDRAH----DENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQ 990
Query: 636 PSGKRKAEDDDKANKKHKKYV----ISDEE 661
+K + KK KK ISDEE
Sbjct: 991 VFSPKKGQKKKSIEKKRKKSKGDSDISDEE 1020
Score = 42.7 bits (99), Expect = 0.001
Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 14/241 (5%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQD---ERGDSGQPSNKELFGDDSEDEG 70
+ ++R+DS S S S E+ + SGS +D ER +E D+
Sbjct: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQRE 1322
Query: 71 ASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHS 130
+ D R +R ER + E + D+D+ E D E R
Sbjct: 1323 WDRDADKDWPRNRDRDRLRERER-ERERDKRRDLDRER--ERLISDSVERDRDRDRDRTF 1379
Query: 131 EAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDD 190
E+ E + K E + D + + D+ER D +Q ++ K + T+
Sbjct: 1380 ESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMD-KDLGSVQGFEETNKSERTES 1438
Query: 191 EERPQLSDDERQQLSEEEKANS---DDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSD 247
E + D+ +L + S + P++ D DE D E++ DEEKM +
Sbjct: 1439 LE----AGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPL 1494
Query: 248 D 248
D
Sbjct: 1495 D 1495
Score = 42.0 bits (97), Expect = 0.002
Identities = 108/556 (19%), Positives = 189/556 (33%), Gaps = 103/556 (18%)
Query: 123 SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
S G HHS S + HS + G IQ R + + Q +
Sbjct: 318 SPAGQHHSPI--SSRHHSSSSQSG----------SSIQRHSPSPRRKRTPSPSYQRTLTP 365
Query: 183 EKMQNTDDEERPQLSDDERQQLSEE------EKANSDDERPVASDNDDEKQNSDDEEQPQ 236
++ LS +R+Q EK D ER + +D + +D +
Sbjct: 366 PLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHER-TSQSHDRRHERREDTRGKR 424
Query: 237 LSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDS 296
+++ + + E+ Q+S +HR DD E +D G D D R R DS
Sbjct: 425 DREKDSREEREYEQDQSSSRDHR--DDREPRD-------GRDRRDA--RDTRDRRELRDS 473
Query: 297 EADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPET 356
D+ +D S D S D D G+ ++E+ PE
Sbjct: 474 RDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDT--------HRKEDTYPE- 524
Query: 357 RIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKV 416
E R + + + +E RT ++ +
Sbjct: 525 ----------------------------ESRSYGRNH---------LREESSRTEIRNES 547
Query: 417 ENTIRWRIRRDEEGN------EIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNH 470
N R IR D G E+ E +R + S + H N + H+
Sbjct: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQ--IDSHSSNSNY----------HDS 595
Query: 471 LFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKM-TLSLADRCSKTQKIRI-LPMAGRDP 528
R + + + R + DS+ R+ D + Q+ + GR+
Sbjct: 596 WETRSSYPERDRYPERDN---RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRND 652
Query: 529 ECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLA 588
E +R E ++EE R+ R ++ R R+++ +R D E E E +
Sbjct: 653 ELERDE--RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE 710
Query: 589 AIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSD-EEGEPSGKRKAEDDDK 647
+ R + +ER R D D E ++ + + K+ + EE E +R+ E + +
Sbjct: 711 RARERERER-EKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERE 769
Query: 648 ANKKHKKYVISDEEEE 663
++ ++ D+E E
Sbjct: 770 RERERERARERDKERE 785
Score = 37.4 bits (85), Expect = 0.045
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 18/216 (8%)
Query: 173 EDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVAS--DNDDEKQNSD 230
++K Q+ D + + +NT++ P + R + E+E ER S +N + + N D
Sbjct: 90 KNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRD 149
Query: 231 DEEQ--------PQLSDEEKMQNSDDERPQASDEE-HRHSDDEEEQDHKSESARGSDSED 281
D + +LS E K Q E + E + + +++ E R S
Sbjct: 150 DSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPS 209
Query: 282 EVLRM-----KRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQ 336
LR KRK++ S S + D + +S +D + S G + P+P
Sbjct: 210 PSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKG-PRTPSPPP 268
Query: 337 PVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGND 372
P+ E+ + +E+ + RIE E + D G D
Sbjct: 269 PIPEDIALGKKYKEKYKVKDRIE-EKTRDGKDRGRD 303
Score = 35.0 bits (79), Expect = 0.22
Identities = 41/199 (20%), Positives = 75/199 (37%), Gaps = 15/199 (7%)
Query: 113 PNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSD--DEERAQG 170
P D + S+ S G ++ S+D D DQS +++ +S D E+ +
Sbjct: 1183 PMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGD--DQSGRKRVLHSGSRDREKTKS 1240
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDE---RPVASDNDDEKQ 227
+ + S D+ + D R S SD + R + D+ D Q
Sbjct: 1241 LEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ 1300
Query: 228 NSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDD-----EEEQDHKSESARGSDSEDE 282
D E + + E+ E + +D++ + D E E++ + + R D E E
Sbjct: 1301 ERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERE 1360
Query: 283 VLRMKRKNAIASDSEADSD 301
L +++ D + D D
Sbjct: 1361 RL---ISDSVERDRDRDRD 1376
>gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
Length = 696
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/198 (20%), Positives = 93/198 (46%), Gaps = 3/198 (1%)
Query: 66 SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
+ED+G G+ + + +E + HE + + SEA ++ + +D
Sbjct: 494 AEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADD 553
Query: 126 GSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEER-AQGSDEDKLQNSDDDEK 184
++ E E E +E E++ + ++K +N++ EE + D+ +++ D++
Sbjct: 554 PNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQY 613
Query: 185 MQNTDDEERPQLSDDERQQLSE--EEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
+ ++E + L+++++++L EE +DE +ND E+Q D+ +P+ +E
Sbjct: 614 QEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHY 673
Query: 243 MQNSDDERPQASDEEHRH 260
+ ++E A+ E H
Sbjct: 674 EEEEEEEEDGAAVAEKSH 691
Score = 65.5 bits (158), Expect = 2e-10
Identities = 54/236 (22%), Positives = 106/236 (44%), Gaps = 37/236 (15%)
Query: 33 NAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASE 92
+A G+E DQ +G+ G D++E + + H + +D SEA +
Sbjct: 484 DAMDNDIVQGAE-DQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA-D 541
Query: 93 RSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSD 152
R+ ED +P+D + G + E E +E+ RE+
Sbjct: 542 RAAVEDINPADDPNNQGED-------------------EFEEAEQV--------REENLP 574
Query: 153 QSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANS 212
++E+ Q++ +E + +E + + D++ N D++ + + ++ ++ L+EE+K
Sbjct: 575 DENEEQKQSNQKQENTE-VEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKREL 633
Query: 213 DDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD 268
+ +DE N+DD+ +D E+ + DD RP+ EEH ++EEE+D
Sbjct: 634 EHNAEETYGENDE--NTDDKN----NDGEEQEVRDDNRPKGR-EEHYEEEEEEEED 682
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/242 (19%), Positives = 105/242 (43%), Gaps = 12/242 (4%)
Query: 65 DSEDEGASHHSGSDNHSERSDNRSEASERSDHEDN-DPSDVDQHSGSEAPNDDEDEGHRS 123
+ + + + +E + R + E+ + + D D D G+E +EG
Sbjct: 448 EQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYE 507
Query: 124 DGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDE 183
H EAEG + + G + +S+ ++ D +D+ Q D+ E
Sbjct: 508 RDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED----INPADDPNNQGEDEFE 563
Query: 184 KMQNTDDEERPQLSDD-ERQQLSEEEKANSD-DERPVASDNDDEKQNSDDEEQPQLSDEE 241
+ + +E P D+ E Q+ S +++ N++ +E V + N D+++++ DE+ + ++EE
Sbjct: 564 EAEQVREENLP---DENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEE 620
Query: 242 KMQNSDDERPQASDE--EHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAD 299
++ +E+ + + E + +++E D K+ + D+ R+ + E +
Sbjct: 621 VQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEE 680
Query: 300 SD 301
D
Sbjct: 681 ED 682
Score = 47.4 bits (111), Expect = 4e-05
Identities = 50/231 (21%), Positives = 103/231 (44%), Gaps = 26/231 (11%)
Query: 131 EAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDD-----EERAQGSDEDKLQNSDDDEKM 185
+AE E E+ ++ D D++ +Q ++D EE A D ++ D
Sbjct: 463 QAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGN 522
Query: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQN 245
++ E+ P+ +D E SE ++A +D P +D Q D+ E+ + EE + +
Sbjct: 523 RHEPREQGPREADPE----SEADRAAVEDINPA---DDPNNQGEDEFEEAEQVREENLPD 575
Query: 246 SDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVP 305
++E+ Q S+++ +++ EE + D+ DE + + + + D + E+
Sbjct: 576 ENEEQKQ-SNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELE 634
Query: 306 KDNSGTMDLFGGADDISS--GSDGEDKPPTPGQPVDEN---GLPQDQQEEE 351
+ T +G D+ + +DGE++ + D+N G + +EEE
Sbjct: 635 HNAEET---YGENDENTDDKNNDGEEQ-----EVRDDNRPKGREEHYEEEE 677
Score = 37.7 bits (86), Expect = 0.034
Identities = 32/153 (20%), Positives = 67/153 (43%), Gaps = 10/153 (6%)
Query: 10 SDADSEAER---KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDS 66
+D +SEA+R +D + D ++ E+ + E+ DE + Q + K+
Sbjct: 534 ADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQ-----E 588
Query: 67 EDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGG 126
E H + N ++ DN E + + E+ D+ + E ++ E+ +D
Sbjct: 589 NTEVEEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEEKKRELEHNAEETYGENDEN 647
Query: 127 SHHSEAEGSEKAHSDDEK-WGREDKSDQSDDEK 158
+ +G E+ DD + GRE+ ++ ++E+
Sbjct: 648 TDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEE 680
Score = 33.5 bits (75), Expect = 0.65
Identities = 24/139 (17%), Positives = 60/139 (43%), Gaps = 10/139 (7%)
Query: 527 DPECQRTEMIKKEEERLRASIRRESQ-QRRMREKQHQRGLSASYLEPDRYDEEEEGEESI 585
DP Q + ++ E+ ++ E++ Q++ +KQ + + D++E+ +
Sbjct: 553 DPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQ 612
Query: 586 SLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDD 645
+ + + EE+ R +++E E+ +D++ +++ DD
Sbjct: 613 YQEEAEEEVQEDLTEEKKRELEHNAEETYGENDEN---------TDDKNNDGEEQEVRDD 663
Query: 646 DKANKKHKKYVISDEEEED 664
++ + + Y +EEEED
Sbjct: 664 NRPKGREEHYEEEEEEEED 682
Score = 33.1 bits (74), Expect = 0.85
Identities = 68/367 (18%), Positives = 124/367 (33%), Gaps = 70/367 (19%)
Query: 129 HSEAEGSEKAHS-DDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDD------ 181
H EAE E RE + Q ++E + ++EE Q + L+ D
Sbjct: 309 HKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQ 368
Query: 182 --DEKMQNTDDEERPQLSDDER----------------------------QQLSEEEKAN 211
+ K Q+ E L R QQ+ E ++
Sbjct: 369 DREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR 428
Query: 212 SDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNS---DDERPQASDEEHRHSDDEEEQD 268
E +++Q Q++ E +Q ++ RPQ ++ + + + +
Sbjct: 429 EHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDN 488
Query: 269 HKSESARGSDSEDEVLRMKRKNAIASDSEAD--------------SDTEVPKDNSGTMDL 314
+ A + E +R N ++E D +D E D + D+
Sbjct: 489 DIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDI 548
Query: 315 FGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLY 374
D + G D ++ + V E LP + +E++ + + E+ + GN
Sbjct: 549 NPADDPNNQGEDEFEE----AEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNP-- 602
Query: 375 FVKLPNFLSVEPRPFDPQYYED-EFEDEEMLDEEGRTRLKLKVENTIRWRIRR-DEEGNE 432
+ D QY E+ E E +E L EE + L+ E T D++ N+
Sbjct: 603 --------DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNND 654
Query: 433 IKESNAR 439
+E R
Sbjct: 655 GEEQEVR 661
Score = 30.4 bits (67), Expect = 5.5
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 16/141 (11%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDER-GDSGQPSNKE 60
AD + G D EAE+ ++ D + +Q+ SN ++ +E +G P +E
Sbjct: 551 ADDPNNQGEDEFEEAEQVREENLPDENEEQKQ----SNQKQENTEVEEHLVMAGNPDQQE 606
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
D+ E A D E+ +E + E+++ +D + ND E++
Sbjct: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTD-------DKNNDGEEQE 659
Query: 121 HRSD----GGSHHSEAEGSEK 137
R D G H E E E+
Sbjct: 660 VRDDNRPKGREEHYEEEEEEE 680
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 66.6 bits (161), Expect = 7e-11
Identities = 58/276 (21%), Positives = 118/276 (42%), Gaps = 14/276 (5%)
Query: 65 DSEDEGASHHSGSD-NHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHR- 122
+ +DE + S D N + S +S+ E +D + PS + S+ + R
Sbjct: 25 EQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRI 84
Query: 123 -SDGGSHHSEAEGSEKAHSDDEKWGREDK----SDQSDDEKIQNSDDEERAQGSDEDKLQ 177
S G +E + E S+ K D+ S + E +N ++ + D ++
Sbjct: 85 VSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRA 144
Query: 178 NS---DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
S D E++ D + S +++++ EE SD E + +D++ N+++EE+
Sbjct: 145 KSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG-SDHETGSSGSSDEQGNNTENEEE 203
Query: 235 PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS 294
EE ++ ++ A ++E D EEE++ + E + E+E ++
Sbjct: 204 ---GVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Query: 295 DSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDK 330
++ D+ +E S ++ G+ SG+DG D+
Sbjct: 261 GNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDE 296
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/202 (22%), Positives = 92/202 (45%), Gaps = 10/202 (4%)
Query: 103 DVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNS 162
D ++ + S P+ E G D + S E+ +S++ E S S DE+ N+
Sbjct: 139 DPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNT 198
Query: 163 DDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDN 222
++EE +G +ED ++ + +E + +DEE + ++E ++ EEE+ ++E D
Sbjct: 199 ENEE--EGVEEDVEEDEEVEEDAE--EDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Query: 223 DDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDE 282
D+K+ +D + + +S E +D R + D K + + +
Sbjct: 255 RDQKEEGNDYD-----TRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISP 309
Query: 283 VLRMKRKNAIASDSEADSDTEV 304
++ R + AS+S AD +++
Sbjct: 310 IV-FDRSGSSASESYADQTSKL 330
Score = 59.7 bits (143), Expect = 8e-09
Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 24/212 (11%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSES---DQDERGDSGQPSN 58
AD + S A E + + D E A GSE + D R S+
Sbjct: 111 ADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSS 170
Query: 59 KELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHED-NDPSDVDQHSGSEAPNDDE 117
KE +SE+ G+ H +GS S+ N +E E ED + +V++ + +E
Sbjct: 171 KEEV--NSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDA-------EE 221
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQ 177
DE DG E E E+ ++E+ +D+ DQ K + +D + R++ SD
Sbjct: 222 DEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQ----KEEGNDYDTRSEASD----- 272
Query: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEK 209
E + TD R D + +E K
Sbjct: 273 --SGSESVSFTDGSVRSGSGTDGSDEKKKERK 302
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/181 (24%), Positives = 80/181 (44%), Gaps = 30/181 (16%)
Query: 76 GSDNHSERSDNRSEASERSDHEDNDPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEAE 133
GS+ D R+ S +S E+ + + D +GS +D++ G + +E E
Sbjct: 151 GSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQ-------GNNTENEEE 203
Query: 134 GSEKAHSDDEKWGREDKSDQSDDEKI-QNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
G E+ +DE E + D +DE++ ++ ++EE +++E+ + ++EE
Sbjct: 204 GVEEDVEEDE----EVEEDAEEDEEVDEDGEEEE-------------EEEEEEEEEEEEE 246
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ DER Q +E+ N D R ASD+ E + D S + ER +
Sbjct: 247 EEEYEQDERDQ---KEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKR 303
Query: 253 A 253
A
Sbjct: 304 A 304
Score = 40.0 bits (92), Expect = 0.007
Identities = 56/248 (22%), Positives = 106/248 (42%), Gaps = 26/248 (10%)
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTD--DEERPQ 195
A S +EK G + D E + DDE S++DK + K + D +R +
Sbjct: 3 ADSREEKDGELNVLDDILTE-VPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQK 61
Query: 196 LSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE---RPQ 252
S RQ +S+ ++ + + + S +EE Q S+ K ++D +
Sbjct: 62 PSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEY-QRSERNKRLDADRKIRLSSS 120
Query: 253 ASDEEHRHSDD-------EEEQDHKSESARGSDSED-EVLRMKRKNAIASDSEADSD--- 301
AS E +++ + + E+ KS + GS+ EV R +++ +S E +S+
Sbjct: 121 ASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG 180
Query: 302 TEVPKDNSGTMDLFG--------GADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPI 353
++ +SG+ D G G ++ + ++ + VDE+G ++++EEE
Sbjct: 181 SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240
Query: 354 PETRIEVE 361
E E E
Sbjct: 241 EEEEEEEE 248
Score = 37.7 bits (86), Expect = 0.034
Identities = 33/158 (20%), Positives = 69/158 (43%), Gaps = 13/158 (8%)
Query: 511 RCSKTQKIRILPMAGRDPECQRTEM--IKKEEERLRASIRRESQQRRMREKQHQRGLSAS 568
R +KIR+ A R+P + E ++K + RA R+ + +R +S
Sbjct: 108 RLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSS 167
Query: 569 YLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKL 628
+ + EE G + + ++ + +G E + +EG EED + +
Sbjct: 168 QSSKEEVNSEEYGSDHETGSSGSSDEQGNNTE--------NEEEGVEEDVEEDEEVEEDA 219
Query: 629 TSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
DEE + G+ + E++++ ++ ++ +EE E D+
Sbjct: 220 EEDEEVDEDGEEEEEEEEEEEEEEEE---EEEEYEQDE 254
Score = 33.1 bits (74), Expect = 0.85
Identities = 25/119 (21%), Positives = 43/119 (36%), Gaps = 2/119 (1%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDE--RGDSGQPSNKE 60
D+E+ + D+E + + + G + + ++E E +QDE + + G +
Sbjct: 208 DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTR 267
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDE 119
DS E S GS +D E + V SGS A D+
Sbjct: 268 SEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYADQ 326
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 66.6 bits (161), Expect = 7e-11
Identities = 58/276 (21%), Positives = 118/276 (42%), Gaps = 14/276 (5%)
Query: 65 DSEDEGASHHSGSD-NHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHR- 122
+ +DE + S D N + S +S+ E +D + PS + S+ + R
Sbjct: 25 EQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRI 84
Query: 123 -SDGGSHHSEAEGSEKAHSDDEKWGREDK----SDQSDDEKIQNSDDEERAQGSDEDKLQ 177
S G +E + E S+ K D+ S + E +N ++ + D ++
Sbjct: 85 VSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRA 144
Query: 178 NS---DDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ 234
S D E++ D + S +++++ EE SD E + +D++ N+++EE+
Sbjct: 145 KSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG-SDHETGSSGSSDEQGNNTENEEE 203
Query: 235 PQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIAS 294
EE ++ ++ A ++E D EEE++ + E + E+E ++
Sbjct: 204 ---GVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Query: 295 DSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDK 330
++ D+ +E S ++ G+ SG+DG D+
Sbjct: 261 GNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDE 296
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/207 (22%), Positives = 94/207 (45%), Gaps = 10/207 (4%)
Query: 103 DVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNS 162
D ++ + S P+ E G D + S E+ +S++ E S S DE+ N+
Sbjct: 139 DPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNT 198
Query: 163 DDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDN 222
++EE +G +ED ++ + +E + +DEE + ++E ++ EEE+ ++E D
Sbjct: 199 ENEE--EGVEEDVEEDEEVEEDAE--EDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Query: 223 DDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDE 282
D+K+ +D + + +S E +D R + D K + + +
Sbjct: 255 RDQKEEGNDYD-----TRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISP 309
Query: 283 VLRMKRKNAIASDSEADSDTEVPKDNS 309
++ R + AS+S A S+ + K +S
Sbjct: 310 IV-FDRSGSSASESYAGSEKKHEKLSS 335
Score = 59.7 bits (143), Expect = 8e-09
Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 24/212 (11%)
Query: 2 ADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSES---DQDERGDSGQPSN 58
AD + S A E + + D E A GSE + D R S+
Sbjct: 111 ADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSS 170
Query: 59 KELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHED-NDPSDVDQHSGSEAPNDDE 117
KE +SE+ G+ H +GS S+ N +E E ED + +V++ + +E
Sbjct: 171 KEEV--NSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDA-------EE 221
Query: 118 DEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQ 177
DE DG E E E+ ++E+ +D+ DQ K + +D + R++ SD
Sbjct: 222 DEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQ----KEEGNDYDTRSEASD----- 272
Query: 178 NSDDDEKMQNTDDEERPQLSDDERQQLSEEEK 209
E + TD R D + +E K
Sbjct: 273 --SGSESVSFTDGSVRSGSGTDGSDEKKKERK 302
Score = 52.4 bits (124), Expect = 1e-06
Identities = 52/212 (24%), Positives = 90/212 (42%), Gaps = 32/212 (15%)
Query: 76 GSDNHSERSDNRSEASERSDHEDNDPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEAE 133
GS+ D R+ S +S E+ + + D +GS +D++ G + +E E
Sbjct: 151 GSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQ-------GNNTENEEE 203
Query: 134 GSEKAHSDDEKWGREDKSDQSDDEKI-QNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
G E+ +DE E + D +DE++ ++ ++EE +++E+ + ++EE
Sbjct: 204 GVEEDVEEDE----EVEEDAEEDEEVDEDGEEEE-------------EEEEEEEEEEEEE 246
Query: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQ 252
+ DER Q +E+ N D R ASD+ E + D S + ER +
Sbjct: 247 EEEYEQDERDQ---KEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKR 303
Query: 253 ASDEEHRHSDDEEEQDHKSESARGSDSEDEVL 284
A D SES GS+ + E L
Sbjct: 304 ARGISPIVFD--RSGSSASESYAGSEKKHEKL 333
Score = 40.0 bits (92), Expect = 0.007
Identities = 56/248 (22%), Positives = 106/248 (42%), Gaps = 26/248 (10%)
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTD--DEERPQ 195
A S +EK G + D E + DDE S++DK + K + D +R +
Sbjct: 3 ADSREEKDGELNVLDDILTE-VPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQK 61
Query: 196 LSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE---RPQ 252
S RQ +S+ ++ + + + S +EE Q S+ K ++D +
Sbjct: 62 PSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEY-QRSERNKRLDADRKIRLSSS 120
Query: 253 ASDEEHRHSDD-------EEEQDHKSESARGSDSED-EVLRMKRKNAIASDSEADSD--- 301
AS E +++ + + E+ KS + GS+ EV R +++ +S E +S+
Sbjct: 121 ASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG 180
Query: 302 TEVPKDNSGTMDLFG--------GADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPI 353
++ +SG+ D G G ++ + ++ + VDE+G ++++EEE
Sbjct: 181 SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240
Query: 354 PETRIEVE 361
E E E
Sbjct: 241 EEEEEEEE 248
Score = 37.7 bits (86), Expect = 0.034
Identities = 33/158 (20%), Positives = 69/158 (43%), Gaps = 13/158 (8%)
Query: 511 RCSKTQKIRILPMAGRDPECQRTEM--IKKEEERLRASIRRESQQRRMREKQHQRGLSAS 568
R +KIR+ A R+P + E ++K + RA R+ + +R +S
Sbjct: 108 RLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSS 167
Query: 569 YLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKL 628
+ + EE G + + ++ + +G E + +EG EED + +
Sbjct: 168 QSSKEEVNSEEYGSDHETGSSGSSDEQGNNTE--------NEEEGVEEDVEEDEEVEEDA 219
Query: 629 TSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
DEE + G+ + E++++ ++ ++ +EE E D+
Sbjct: 220 EEDEEVDEDGEEEEEEEEEEEEEEEE---EEEEYEQDE 254
Score = 32.3 bits (72), Expect = 1.4
Identities = 33/158 (20%), Positives = 52/158 (32%), Gaps = 18/158 (11%)
Query: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDE--RGDSGQPSNKE 60
D+E+ + D+E + + + G + + ++E E +QDE + + G +
Sbjct: 208 DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTR 267
Query: 61 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 120
DS E S GS +D E + V SGS A
Sbjct: 268 SEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSA-------- 319
Query: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEK 158
GSEK H R + DQ+ K
Sbjct: 320 --------SESYAGSEKKHEKLSSSVRAVRKDQTSKLK 349
>gi|190194423 SPARC-like 1 [Homo sapiens]
Length = 664
Score = 65.5 bits (158), Expect = 2e-10
Identities = 77/410 (18%), Positives = 153/410 (37%), Gaps = 40/410 (9%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERG-DSGQPSNKELFGDDSEDEGAS 72
+EAE + ++ ++ D + A S+ S+ + E+ + G+ S++EL D ED
Sbjct: 47 AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGH 106
Query: 73 -----HHSGSDNHSERSDNRSEASERSDHEDND-----PSDVDQHSGSEAPNDDEDEGHR 122
++ ++ + ++ SE E+ E+ D S + E+ E+ +
Sbjct: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQ 166
Query: 123 SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
SHH S+ HS G D+ +Q D I N ++EE + +
Sbjct: 167 PRNYSHHQLNRSSK--HSQ----GLRDQGNQEQDPNISNGEEEEEKEPGEVGT------- 213
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
N + E + +L + EE+ SDD + + +DE ++E
Sbjct: 214 ---HNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQED 270
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
N++ E AS+ ++H + E Q + ++ + S + K + D
Sbjct: 271 NSNAEMEEENASN-VNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGN 329
Query: 303 EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362
P+++ +D G D G+DG + + + ++ + +IE +
Sbjct: 330 TTPRNHG--VDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQR 387
Query: 363 PKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRL 412
KV+ + N + EP + +EE EG R+
Sbjct: 388 EKVHEN----------ENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRV 427
Score = 52.0 bits (123), Expect = 2e-06
Identities = 55/270 (20%), Positives = 107/270 (39%), Gaps = 37/270 (13%)
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS---- 127
S HS + DN + S R++ E+N+ A + ++D H+++ S
Sbjct: 25 SDHSKPTAETVAPDNTAIPSLRAEAEENEKET--------AVSTEDDSHHKAEKSSVLKS 76
Query: 128 -HHSEAEGSEKAHSDDEKWGREDKSDQSD---------------DEKIQNSDDEERAQGS 171
S + +E+ S ++ G +D+ D D K S+ +E+
Sbjct: 77 KEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSE 136
Query: 172 DEDKLQ---NSDDDEKMQNT---DDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE 225
+ D L +S D Q + +E + Q + QL+ K +S R + D
Sbjct: 137 NTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK-HSQGLRDQGNQEQDP 195
Query: 226 KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR 285
++ +EE+ + E N + ER EH +S EE+ + SD +V +
Sbjct: 196 NISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSK 255
Query: 286 MKRKNAIASDSEAD--SDTEVPKDNSGTMD 313
M+ + E + S+ E+ ++N+ ++
Sbjct: 256 MQEDEFDQGNQEQEDNSNAEMEEENASNVN 285
Score = 38.1 bits (87), Expect = 0.026
Identities = 32/167 (19%), Positives = 72/167 (43%), Gaps = 6/167 (3%)
Query: 19 KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQP--SNKELFGDDSEDEGASHHSG 76
++ + S+++ ++ENA++ + Q + G +G SN + + + E A
Sbjct: 266 QEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSE-ALLMEP 324
Query: 77 SDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE---APNDDEDEGHRSDGGSHHSEAE 133
+D+ + N + D D+ +D +HS S+ P+ E R+ ++H + E
Sbjct: 325 TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
Query: 134 GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
+ ++E G + + + +K +NS +EE ++ D
Sbjct: 385 EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVD 431
>gi|190341024 SPARC-like 1 [Homo sapiens]
Length = 664
Score = 65.5 bits (158), Expect = 2e-10
Identities = 77/410 (18%), Positives = 153/410 (37%), Gaps = 40/410 (9%)
Query: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERG-DSGQPSNKELFGDDSEDEGAS 72
+EAE + ++ ++ D + A S+ S+ + E+ + G+ S++EL D ED
Sbjct: 47 AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGH 106
Query: 73 -----HHSGSDNHSERSDNRSEASERSDHEDND-----PSDVDQHSGSEAPNDDEDEGHR 122
++ ++ + ++ SE E+ E+ D S + E+ E+ +
Sbjct: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQ 166
Query: 123 SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
SHH S+ HS G D+ +Q D I N ++EE + +
Sbjct: 167 PRNYSHHQLNRSSK--HSQ----GLRDQGNQEQDPNISNGEEEEEKEPGEVGT------- 213
Query: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
N + E + +L + EE+ SDD + + +DE ++E
Sbjct: 214 ---HNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQED 270
Query: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302
N++ E AS+ ++H + E Q + ++ + S + K + D
Sbjct: 271 NSNAEMEEENASN-VNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGN 329
Query: 303 EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362
P+++ +D G D G+DG + + + ++ + +IE +
Sbjct: 330 TTPRNHG--VDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQR 387
Query: 363 PKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRL 412
KV+ + N + EP + +EE EG R+
Sbjct: 388 EKVHEN----------ENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRV 427
Score = 52.0 bits (123), Expect = 2e-06
Identities = 55/270 (20%), Positives = 107/270 (39%), Gaps = 37/270 (13%)
Query: 72 SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS---- 127
S HS + DN + S R++ E+N+ A + ++D H+++ S
Sbjct: 25 SDHSKPTAETVAPDNTAIPSLRAEAEENEKET--------AVSTEDDSHHKAEKSSVLKS 76
Query: 128 -HHSEAEGSEKAHSDDEKWGREDKSDQSD---------------DEKIQNSDDEERAQGS 171
S + +E+ S ++ G +D+ D D K S+ +E+
Sbjct: 77 KEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSE 136
Query: 172 DEDKLQ---NSDDDEKMQNT---DDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE 225
+ D L +S D Q + +E + Q + QL+ K +S R + D
Sbjct: 137 NTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK-HSQGLRDQGNQEQDP 195
Query: 226 KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR 285
++ +EE+ + E N + ER EH +S EE+ + SD +V +
Sbjct: 196 NISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSK 255
Query: 286 MKRKNAIASDSEAD--SDTEVPKDNSGTMD 313
M+ + E + S+ E+ ++N+ ++
Sbjct: 256 MQEDEFDQGNQEQEDNSNAEMEEENASNVN 285
Score = 38.1 bits (87), Expect = 0.026
Identities = 32/167 (19%), Positives = 72/167 (43%), Gaps = 6/167 (3%)
Query: 19 KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQP--SNKELFGDDSEDEGASHHSG 76
++ + S+++ ++ENA++ + Q + G +G SN + + + E A
Sbjct: 266 QEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSE-ALLMEP 324
Query: 77 SDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE---APNDDEDEGHRSDGGSHHSEAE 133
+D+ + N + D D+ +D +HS S+ P+ E R+ ++H + E
Sbjct: 325 TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
Query: 134 GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
+ ++E G + + + +K +NS +EE ++ D
Sbjct: 385 EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVD 431
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/310 (19%), Positives = 124/310 (40%), Gaps = 13/310 (4%)
Query: 52 DSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE 111
+SG+ SN+ G + S S +HS R ++S+ RS + + S S
Sbjct: 296 ESGK-SNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 354
Query: 112 APNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE-ERAQG 170
+ R HS + + EK ++K + + E+ + + E ER +
Sbjct: 355 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
D DK + D ++ + + ER + + +R + E+E+ + S DEK+ D
Sbjct: 415 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 474
Query: 231 DEEQ--PQLSDEEKMQNSDD-----ERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV 283
+ + P+ + + S R ++S R S + + +S S R + +D+
Sbjct: 475 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDK- 533
Query: 284 LRMKRKNAIASDSEADSDTEVPK---DNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 340
R K ++ I+ E + T + K D G L + + ++ + + VD+
Sbjct: 534 KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD 593
Query: 341 NGLPQDQQEE 350
P+ ++ +
Sbjct: 594 KDAPRTEENK 603
Score = 62.0 bits (149), Expect = 2e-09
Identities = 68/346 (19%), Positives = 131/346 (37%), Gaps = 28/346 (8%)
Query: 19 KDSDSGSDSDSDQENAASGSNASG-SESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+++ S + + E+ S G S S + S S+ S+ SH+
Sbjct: 283 REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSR 342
Query: 78 DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEK 137
+R ++S +RS + S HS + + E + E E +
Sbjct: 343 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 402
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLS 197
+ EK ++K + EK + D E+ + E + + D EK + D E+ +
Sbjct: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK--ERE 460
Query: 198 DDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ-----------PQLSDEEKMQNS 246
D +++ E+ K + P S N + S E+ P+ S K ++S
Sbjct: 461 KDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSS 520
Query: 247 DDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPK 306
P++ +++ + E+E+DH SE R + + S ++ D ++ K
Sbjct: 521 RSPSPRSRNKKDKKR--EKERDHISERRE---------RERSTSMRKSSNDRDGKEKLEK 569
Query: 307 DNSGTMDLFGGADDISSGS---DGEDKPPTPGQPVDENGLPQDQQE 349
+++ + + SS S D +D P T + NG Q +E
Sbjct: 570 NSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEE 615
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/191 (20%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 474 RQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRT 533
R+G + K++ + + HS + K +R QK R + P +R+
Sbjct: 303 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRS 359
Query: 534 EMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNR 593
+ ++ + R R+ R + + R + K+ +R E DR E E +E +
Sbjct: 360 KSRERRKSRSRSHSRDKRKDTREKIKEKER-----VKEKDREKEREREKER------EKE 408
Query: 594 YKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHK 653
+ G ++R + D ++ E+D+ + K + D+E K K +D +K +K +
Sbjct: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE-----KEKEQDKEKEREKDR 463
Query: 654 KYVISDEEEED 664
I ++ ++D
Sbjct: 464 SKEIDEKRKKD 474
Score = 37.7 bits (86), Expect = 0.034
Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 31/153 (20%)
Query: 501 HRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQ 560
H+K + S R S+++ RD E IK++E +E ++ + REK+
Sbjct: 355 HKKRSKSRERRKSRSRS------HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 408
Query: 561 HQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQ 620
+RG + DR E E+ E K++ K ER R + D E++K Q
Sbjct: 409 KERGKN-----KDRDKEREKDRE-------KDKEKD---REREREKEHEKDRDKEKEKEQ 453
Query: 621 RLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHK 653
D+E E R E D+K K K
Sbjct: 454 ----------DKEKEREKDRSKEIDEKRKKDKK 476
Score = 34.7 bits (78), Expect = 0.29
Identities = 31/130 (23%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 542 RLRASIRRESQ---QRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGI 598
R R RR S+ ++R + ++ ++ S S+ R D E+ +E K R K
Sbjct: 342 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE-------KERVKEKD 394
Query: 599 RE---ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKY 655
RE ER + + + G +D+ + + K D+E + +R+ E + +K+ +K
Sbjct: 395 REKEREREKEREKEKERGKNKDRDKE--REKDREKDKEKDREREREKEHEKDRDKEKEKE 452
Query: 656 VISDEEEEDD 665
++E E D
Sbjct: 453 QDKEKEREKD 462
Score = 33.9 bits (76), Expect = 0.50
Identities = 38/164 (23%), Positives = 68/164 (41%), Gaps = 20/164 (12%)
Query: 520 ILPMAGRDPECQ----RTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRY 575
I P +G+ E + R+ K ++ RR+ Q + R + H R S S + R
Sbjct: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR--SRSRQKDRRR 350
Query: 576 DEEEEGEESISLAAIKNRYKGGIRE----------ERARIYSSDSDEGSEEDKAQRLLK- 624
+ + S S K+R + R+ E+ R+ D ++ E +K + K
Sbjct: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 410
Query: 625 -AKKLTSDEEGEPSGKRKAEDD--DKANKKHKKYVISDEEEEDD 665
K D+E E ++ E D + K+H+K ++E+E D
Sbjct: 411 RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 454
Score = 32.0 bits (71), Expect = 1.9
Identities = 40/198 (20%), Positives = 71/198 (35%), Gaps = 32/198 (16%)
Query: 486 KTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRA 545
+ K R HS D + + +R + R+ E +R + +KE+ER +
Sbjct: 364 RRKSRSRSHSRDKRKDTREKIKEKERVKEKD---------REKEREREKEREKEKERGKN 414
Query: 546 SIR-----------RESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRY 594
R +E + R REK+H++ + ++E E + S + + +
Sbjct: 415 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 474
Query: 595 KGGIREERARIYSSDSDEGSEE---------DKAQRLLKAKKLTSDEEGEPSGKRKAEDD 645
K R+ S S S E ++ R K K S P + K
Sbjct: 475 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK---K 531
Query: 646 DKANKKHKKYVISDEEEE 663
DK +K + ++ E E
Sbjct: 532 DKKREKERDHISERRERE 549
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/310 (19%), Positives = 124/310 (40%), Gaps = 13/310 (4%)
Query: 52 DSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE 111
+SG+ SN+ G + S S +HS R ++S+ RS + + S S
Sbjct: 180 ESGK-SNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 238
Query: 112 APNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDE-ERAQG 170
+ R HS + + EK ++K + + E+ + + E ER +
Sbjct: 239 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 298
Query: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
D DK + D ++ + + ER + + +R + E+E+ + S DEK+ D
Sbjct: 299 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 358
Query: 231 DEEQ--PQLSDEEKMQNSDD-----ERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEV 283
+ + P+ + + S R ++S R S + + +S S R + +D+
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDK- 417
Query: 284 LRMKRKNAIASDSEADSDTEVPK---DNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 340
R K ++ I+ E + T + K D G L + + ++ + + VD+
Sbjct: 418 KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD 477
Query: 341 NGLPQDQQEE 350
P+ ++ +
Sbjct: 478 KDAPRTEENK 487
Score = 62.0 bits (149), Expect = 2e-09
Identities = 68/346 (19%), Positives = 131/346 (37%), Gaps = 28/346 (8%)
Query: 19 KDSDSGSDSDSDQENAASGSNASG-SESDQDERGDSGQPSNKELFGDDSEDEGASHHSGS 77
+++ S + + E+ S G S S + S S+ S+ SH+
Sbjct: 167 REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSR 226
Query: 78 DNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEK 137
+R ++S +RS + S HS + + E + E E +
Sbjct: 227 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 286
Query: 138 AHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLS 197
+ EK ++K + EK + D E+ + E + + D EK + D E+ +
Sbjct: 287 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK--ERE 344
Query: 198 DDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQ-----------PQLSDEEKMQNS 246
D +++ E+ K + P S N + S E+ P+ S K ++S
Sbjct: 345 KDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSS 404
Query: 247 DDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPK 306
P++ +++ + E+E+DH SE R + + S ++ D ++ K
Sbjct: 405 RSPSPRSRNKKDKKR--EKERDHISERRE---------RERSTSMRKSSNDRDGKEKLEK 453
Query: 307 DNSGTMDLFGGADDISSGS---DGEDKPPTPGQPVDENGLPQDQQE 349
+++ + + SS S D +D P T + NG Q +E
Sbjct: 454 NSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEE 499
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/191 (20%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 474 RQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRT 533
R+G + K++ + + HS + K +R QK R + P +R+
Sbjct: 187 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRS 243
Query: 534 EMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNR 593
+ ++ + R R+ R + + R + K+ +R E DR E E +E +
Sbjct: 244 KSRERRKSRSRSHSRDKRKDTREKIKEKER-----VKEKDREKEREREKER------EKE 292
Query: 594 YKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHK 653
+ G ++R + D ++ E+D+ + K + D+E K K +D +K +K +
Sbjct: 293 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE-----KEKEQDKEKEREKDR 347
Query: 654 KYVISDEEEED 664
I ++ ++D
Sbjct: 348 SKEIDEKRKKD 358
Score = 37.7 bits (86), Expect = 0.034
Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 31/153 (20%)
Query: 501 HRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQ 560
H+K + S R S+++ RD E IK++E +E ++ + REK+
Sbjct: 239 HKKRSKSRERRKSRSRS------HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 292
Query: 561 HQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQ 620
+RG + DR E E+ E K++ K ER R + D E++K Q
Sbjct: 293 KERGKN-----KDRDKEREKDRE-------KDKEKD---REREREKEHEKDRDKEKEKEQ 337
Query: 621 RLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHK 653
D+E E R E D+K K K
Sbjct: 338 ----------DKEKEREKDRSKEIDEKRKKDKK 360
Score = 34.7 bits (78), Expect = 0.29
Identities = 31/130 (23%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 542 RLRASIRRESQ---QRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGI 598
R R RR S+ ++R + ++ ++ S S+ R D E+ +E K R K
Sbjct: 226 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE-------KERVKEKD 278
Query: 599 RE---ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKY 655
RE ER + + + G +D+ + + K D+E + +R+ E + +K+ +K
Sbjct: 279 REKEREREKEREKEKERGKNKDRDKE--REKDREKDKEKDREREREKEHEKDRDKEKEKE 336
Query: 656 VISDEEEEDD 665
++E E D
Sbjct: 337 QDKEKEREKD 346
Score = 33.9 bits (76), Expect = 0.50
Identities = 38/164 (23%), Positives = 68/164 (41%), Gaps = 20/164 (12%)
Query: 520 ILPMAGRDPECQ----RTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRY 575
I P +G+ E + R+ K ++ RR+ Q + R + H R S S + R
Sbjct: 177 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNR--SRSRQKDRRR 234
Query: 576 DEEEEGEESISLAAIKNRYKGGIRE----------ERARIYSSDSDEGSEEDKAQRLLK- 624
+ + S S K+R + R+ E+ R+ D ++ E +K + K
Sbjct: 235 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 294
Query: 625 -AKKLTSDEEGEPSGKRKAEDD--DKANKKHKKYVISDEEEEDD 665
K D+E E ++ E D + K+H+K ++E+E D
Sbjct: 295 RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 338
Score = 32.0 bits (71), Expect = 1.9
Identities = 40/198 (20%), Positives = 71/198 (35%), Gaps = 32/198 (16%)
Query: 486 KTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRA 545
+ K R HS D + + +R + R+ E +R + +KE+ER +
Sbjct: 248 RRKSRSRSHSRDKRKDTREKIKEKERVKEKD---------REKEREREKEREKEKERGKN 298
Query: 546 SIR-----------RESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRY 594
R +E + R REK+H++ + ++E E + S + + +
Sbjct: 299 KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 358
Query: 595 KGGIREERARIYSSDSDEGSEE---------DKAQRLLKAKKLTSDEEGEPSGKRKAEDD 645
K R+ S S S E ++ R K K S P + K
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK---K 415
Query: 646 DKANKKHKKYVISDEEEE 663
DK +K + ++ E E
Sbjct: 416 DKKREKERDHISERRERE 433
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.301 0.124 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,410,391
Number of Sequences: 37866
Number of extensions: 1706636
Number of successful extensions: 44163
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 1160
Number of HSP's that attempted gapping in prelim test: 9816
Number of HSP's gapped (non-prelim): 14761
length of query: 666
length of database: 18,247,518
effective HSP length: 109
effective length of query: 557
effective length of database: 14,120,124
effective search space: 7864909068
effective search space used: 7864909068
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.