Search of human proteins with 20127519

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127519 TPX2, microtubule-associated protein homolog [Homo
sapiens]
         (747 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127519 TPX2, microtubule-associated protein homolog [Homo s...  1490   0.0  
gi|148746195 trichohyalin [Homo sapiens]                               65   2e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     65   2e-10
gi|110349719 titin isoform N2-A [Homo sapiens]                         61   3e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       55   2e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    51   4e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    51   4e-06
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    51   4e-06
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    51   4e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     50   8e-06
gi|8922940 gamma-taxilin [Homo sapiens]                                49   1e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        49   2e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        49   2e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         49   2e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         49   2e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         49   2e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         49   2e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         49   2e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         49   2e-05
gi|104526627 triadin [Homo sapiens]                                    49   2e-05
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]                       48   3e-05
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]                       48   3e-05
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]    47   6e-05
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]     47   6e-05
gi|118918413 MICAL C-terminal like [Homo sapiens]                      46   1e-04
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    46   1e-04
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          46   1e-04
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    46   1e-04
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    46   1e-04
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    45   2e-04

>gi|20127519 TPX2, microtubule-associated protein homolog [Homo
           sapiens]
          Length = 747

 Score = 1490 bits (3857), Expect = 0.0
 Identities = 747/747 (100%), Positives = 747/747 (100%)

Query: 1   MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTP 60
           MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTP
Sbjct: 1   MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTP 60

Query: 61  LRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRR 120
           LRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRR
Sbjct: 61  LRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRR 120

Query: 121 SLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTA 180
           SLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTA
Sbjct: 121 SLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTA 180

Query: 181 EKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLAL 240
           EKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLAL
Sbjct: 181 EKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLAL 240

Query: 241 AGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKG 300
           AGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKG
Sbjct: 241 AGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKG 300

Query: 301 CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV 360
           CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV
Sbjct: 301 CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV 360

Query: 361 TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK 420
           TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK
Sbjct: 361 TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK 420

Query: 421 KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP 480
           KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP
Sbjct: 421 KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP 480

Query: 481 ITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF 540
           ITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF
Sbjct: 481 ITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF 540

Query: 541 DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR 600
           DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR
Sbjct: 541 DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR 600

Query: 601 GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
           GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF
Sbjct: 601 GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660

Query: 661 QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK 720
           QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK
Sbjct: 661 QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK 720

Query: 721 YQGLEIKSSDQPLTVPVSPKFSTRFHC 747
           YQGLEIKSSDQPLTVPVSPKFSTRFHC
Sbjct: 721 YQGLEIKSSDQPLTVPVSPKFSTRFHC 747


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 126/636 (19%), Positives = 267/636 (41%), Gaps = 83/636 (13%)

Query: 116  QPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSA 175
            Q +RR  +L  +++  ++++   + + +R    +  ++ L  ++ +      K EEE   
Sbjct: 499  QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558

Query: 176  HQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQ-EVVEMRKKNEE 234
             Q+  E+     ++ +    +      +Q+ LK  +E+ LE+ +K ++ E +E  ++ E+
Sbjct: 559  EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618

Query: 235  FKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK------EVNFTSELR 288
              K       +P ++   Q+ KS +   R  +++++  + + E +      E      L+
Sbjct: 619  RLKRE-----EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673

Query: 289  KHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQ-QVEDFHKRTPNRYHLRSK 347
            +      R  +         L++ ++    E + + +P  Q Q+E       ++ + R +
Sbjct: 674  REHEEERREQE---------LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 348  KDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKAREL 407
            K +      +    +  R+ +   LQ +   RA       + + EE  +   ++++A E 
Sbjct: 725  KQEGQRRRQEQEEKRRRRESE---LQWQEEERA-----HRQQQEEEQRRDFTWQWQAEEK 776

Query: 408  DPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKIL 467
              R   G   L  +PP++   E     L  E+R Q+RE +   E+E  E   R    +  
Sbjct: 777  SER---GRQRLSARPPLREQRER---QLRAEER-QQREQRFLPEEEEKEQRRRQRRER-- 827

Query: 468  EDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEE--DEPVVIKAQPVPHYGVPFKP 525
                   EK++  +   +     L+ R R    ++EE+   E    +          ++ 
Sbjct: 828  -------EKELQFLEEEEQ----LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW 876

Query: 526  QIPEAR-----TVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLP 580
            Q+ E R     T+   P   +   KE+QL +E++ +ELQ+ E  K +             
Sbjct: 877  QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE-EELQREEREKRRRQE---------Q 926

Query: 581  EKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVP 640
            E++ +   Q     L+ +    L+ +  K + +E  RQ ++    + +   ++ +EP   
Sbjct: 927  ERQYREEEQ-----LQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981

Query: 641  KKEKKSVAEGLSGSLVQEPFQLATEKRAK-ERQELEKR-------MAEVEAQKAQQLEEA 692
            +++++         L QE  QL  E+R K  RQE E++         E E    ++ E+ 
Sbjct: 982  RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041

Query: 693  RLQEEE---QKKEELARLRRELVHKANPIRKYQGLE 725
            RLQE E   +++EEL +   +L+ +    R+ Q LE
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 134/655 (20%), Positives = 260/655 (39%), Gaps = 105/655 (16%)

Query: 86   EKENLVEQSIPSNACSSLEVEAA----ISRKTPAQPQRRSLRLSAQKD--------LEQK 133
            E+E  +EQ +       LE E      + R+ P + +R+ L  S +++         EQ+
Sbjct: 593  EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 134  EKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGR 193
            E+   ++K +              ++ ++    K+  EE    Q+ AE+     E+ + R
Sbjct: 653  ERREQRLKREE-------------EEERLEQRLKREHEEERREQELAEE-----EQEQAR 694

Query: 194  HTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQ 253
              +    P  Q         +LE     +Q  V  R + +E         GQ  ++   +
Sbjct: 695  ERIKSRIPKWQ--------WQLESEADARQSKVYSRPRKQE---------GQRRRQEQEE 737

Query: 254  VTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGK 313
              +  +   +  E  + H + QEE +  +FT + +    S  R  +  +   P    + +
Sbjct: 738  KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE-RGRQRLSARPPLREQRER 796

Query: 314  KRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQ 373
            +   +E          + E+  +R   R   R ++ ++  L  +              LQ
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQR---REREKELQFLEEEEQ------------LQ 841

Query: 374  TKHRARAVTCKSTAELEAEELEKLQQYKFKAR---ELDPRILEGGPILPKKPPVKPPTEP 430
             + RA+ +  +     E +E  + Q+ +   +   +L+         L  KP ++     
Sbjct: 842  RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901

Query: 431  IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFA 490
                L+ E+   +RE ++K   +  E   R       E+ +   E+++L     K     
Sbjct: 902  EQQLLQEEEEELQREEREKRRRQEQERQYRE------EEQLQQEEEQLLREEREKRRRQE 955

Query: 491  LKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQ 550
             + + R   K  ++E++ +  + +         K +  E    E      + R+K R+ +
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015

Query: 551  KEKKIK---ELQKGEVPKFKALPLPHFDTINLPEKK-----VKNVTQIEPFCL----ETD 598
             E++ +   ELQ+ E    + L     +   L E++      + + Q E   L    ET 
Sbjct: 1016 WERQYRKKDELQQEE----EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071

Query: 599  RRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQE 658
            RR  L+ Q   ++ EEEL+Q++E          ++ +EP   +++++         L QE
Sbjct: 1072 RRQELERQ---YRKEEELQQEEEQ---------LLREEPEKRRRQERERQCREEEELQQE 1119

Query: 659  PFQLATEKRAKE-RQELEKRMAEVEAQKAQQLEEARLQEEEQK--KEELARLRRE 710
              QL  E+R K  RQELE++  E E  + QQ EE  L+EE +K  ++EL R  RE
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEE--EVQQEEEQLLREEPEKRRRQELERQYRE 1172



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 117/646 (18%), Positives = 256/646 (39%), Gaps = 67/646 (10%)

Query: 115  AQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGS 174
            +Q QRR  +   Q + E+K + H        A P + +++   +++     ++   EE  
Sbjct: 865  SQEQRRDQKWRWQLEEERKRRRHTLY-----AKPALQEQLRKEQQLLQEEEEELQREERE 919

Query: 175  AHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQ-------EVVE 227
              +   ++     E+   +     +   ++K  +   E++  K  K+QQ       E  E
Sbjct: 920  KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979

Query: 228  MRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSEL 287
             R++ E  KK       + +++   Q+ +      R  E  +Q+ K  E  +E     +L
Sbjct: 980  KRRRQEREKKYREE---EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE---EEQL 1033

Query: 288  RKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDF---HKRTPNRYHL 344
             +      R+             Q ++R + E       L Q+ E      + T  R  L
Sbjct: 1034 LREEREKRRL-------------QERERQYREEEE----LQQEEEQLLGEERETRRRQEL 1076

Query: 345  -RSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFK 403
             R  + +  L   +  + +   +P+    Q + R     C+   EL+ EE + L++ + K
Sbjct: 1077 ERQYRKEEELQQEEEQLLR--EEPEKRRRQERERQ----CREEEELQQEEEQLLREEREK 1130

Query: 404  AR--ELDPRILEGGPI------LPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHF 455
             R  EL+ +  E   +      L ++ P K   + +      E+ +Q+ E +   E++  
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190

Query: 456  EFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQP 515
                R    +  E++     K+       +S    LK +   P KE+   D  V  K + 
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSD---LKWQWE-PEKENAVRDNKVYCKGRE 1246

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
               +      Q+ + ++ +        + +ER  ++E++  + +    P+ + L      
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQ-QERDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 576  TINLPEKKVKNVTQI-------EPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKAR 628
                 ++K +   Q+       +    ETDR+   + Q  + + E+ LR+Q+    F+  
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365

Query: 629  PNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKE-RQELEKRMAEVEAQKAQ 687
                  Q     ++E++   +      ++E  QL  ++R ++ RQ+ +++  E E Q ++
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425

Query: 688  QLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPL 733
            Q  + + +EEEQ+     R  R+ + +   +R+ +  + +  +Q L
Sbjct: 1426 QERDRKFREEEQQVRRQER-ERKFLEEEQQLRQERHRKFREEEQLL 1470



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 122/647 (18%), Positives = 251/647 (38%), Gaps = 99/647 (15%)

Query: 109  ISRKTPAQPQR-RSLRLSAQKDLEQK----EKHHVKMKAKRCATPVIIDEILPSKKMKVS 163
            +S + P + QR R LR   ++  EQ+    E+   + + +R      +  +   ++++  
Sbjct: 784  LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843

Query: 164  NNKKKPEEEGSAHQDTAEKNASSP-------------EKAKGRHTVPCMPPAKQKFLKST 210
               ++ +EE    Q+  E+  S               E+ + RHT+   P A Q+ L+  
Sbjct: 844  ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP-ALQEQLRKE 902

Query: 211  EEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQ 270
            ++   E+  ++Q+E  E R++ E+ ++       + +++   Q+ +      R  ER +Q
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQERQYREE---EQLQQEEEQLLREEREKRRRQERERQ 959

Query: 271  HPKNQE-EYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQ 329
            + K+++ + KE     E    P    R  +           + K R  +E       L +
Sbjct: 960  YRKDKKLQQKEEQLLGE---EPEKRRRQER-----------EKKYREEEELQQEEEQLLR 1005

Query: 330  QVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAEL 389
            +  +  +R       R KKD++             +  +  +L+ +   R +  +     
Sbjct: 1006 EEREKRRRQEWERQYR-KKDEL-------------QQEEEQLLREEREKRRLQERERQYR 1051

Query: 390  EAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKK 449
            E EEL++ ++          R  E      K+  ++   E +  +   ++R QERE + +
Sbjct: 1052 EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111

Query: 450  TEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPV 509
             E+E                 +   E+++L     K     L+ + R   +E+ +++E  
Sbjct: 1112 EEEE-----------------LQQEEEQLLREEREKRRRQELERQYR--EEEEVQQEEEQ 1152

Query: 510  VIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKAL 569
            +++ +P        + Q  E   ++          +E QL +E++ K  Q+ E       
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQ---------QEEEQLLREEQEKRRQERE------- 1196

Query: 570  PLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARP 629
               + +   L  +K K   + E      D+R  LK Q W+ + E  +R  K     K R 
Sbjct: 1197 -RQYREEEELQRQKRKQRYRDE------DQRSDLKWQ-WEPEKENAVRDNKVYC--KGRE 1246

Query: 630  NTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRA---KERQELEKRMAEVEAQKA 686
            N    Q      ++++S  +       Q+      E+R    ++R   E+   E E QK 
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306

Query: 687  QQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPL 733
             +  + + QEE+Q   E    +R         R+ + L  +  +QPL
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 37/206 (17%), Positives = 94/206 (45%), Gaps = 9/206 (4%)

Query: 525 PQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKF-KALPLPHFDTINLPEKK 583
           P   + R  E+       R++++Q ++E++ +  Q+ E  ++ K   +   +   L E++
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 584 VKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQK-----EAACFKARPNTVISQEPF 638
            +   +++    E ++   L+ Q  + + +EE +QQ+     +    K        QE  
Sbjct: 265 PQRQRELQE---EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 639 VPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEE 698
             ++E++   E      ++   +   E++ +  QE E+R  ++  ++ ++  E +L+ E+
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381

Query: 699 QKKEELARLRRELVHKANPIRKYQGL 724
           Q + E    R + + +   +R+ Q L
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQL 407



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 43/194 (22%), Positives = 89/194 (45%), Gaps = 13/194 (6%)

Query: 543 RDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGA 602
           R +E  L+KE++  +LQ+ E  + + L         L  ++++   Q E    E  ++  
Sbjct: 247 RKRETVLRKEEE--KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE----EQQQQRL 300

Query: 603 LKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQL 662
            + Q  + + EEE R+Q+E    + +      QE    ++ ++   E     L +E  + 
Sbjct: 301 RREQQLRRKQEEERREQQEER--REQQERREQQEERREQQLRREQEERREQQLRREQEEE 358

Query: 663 ATEKRAKERQELEKR----MAEVEAQKAQQLE-EARLQEEEQKKEELARLRRELVHKANP 717
             E++ +  QE E+R      E + ++ QQL  E +L+ E+Q + E    R + + +   
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418

Query: 718 IRKYQGLEIKSSDQ 731
           +R+ Q L  +  ++
Sbjct: 419 LRREQQLRREQEEE 432



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 39/193 (20%), Positives = 87/193 (45%), Gaps = 7/193 (3%)

Query: 543  RDKERQLQKEKKIKELQKGEVPKFKALPLPHF--DTINLPEKKVKNVTQIEPFCLETDRR 600
            R++E+QL ++++ ++ ++ E    +      F  +   L +++ +   + E    E + +
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476

Query: 601  GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
               + +  +  LEEE + +++    K R   + SQEP     E+K + E       Q   
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP-----ERKFLEEEQQLHRQQRQR 1531

Query: 661  QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK 720
            +   E++   RQE  ++  +   +K ++ E+ R + EEQ+     R R+  + +    R+
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 721  YQGLEIKSSDQPL 733
             Q  +    +Q L
Sbjct: 1592 EQERKFMEDEQQL 1604



 Score = 36.6 bits (83), Expect = 0.087
 Identities = 22/91 (24%), Positives = 46/91 (50%)

Query: 641 KKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQK 700
           ++EK+         + QE  +    KR    ++ E+++ E E Q+ ++L+E   Q  + +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 701 KEELARLRRELVHKANPIRKYQGLEIKSSDQ 731
           ++EL R R+E   +   +R+ Q L  K  ++
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEE 313



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 113/601 (18%), Positives = 220/601 (36%), Gaps = 96/601 (15%)

Query: 118  QRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQ 177
            Q+R      ++ LE++E+   K + +              K  +     ++  EE    Q
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDR--------------KSQEEKQLLREEREEKRRRQ 1332

Query: 178  DTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKK 237
            +T  K     +  + R   P     + +  +  E +  E+  K  +E   +R++  E +K
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE-RK 1391

Query: 238  LALAGIGQPVKKSVSQVTKSVDFHFRTDE----RIKQHPKNQEEYKEVNFTSELRKHPSS 293
                      ++   Q+ +  D  FR +E    R ++  K +EE ++V      RK    
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF--- 1448

Query: 294  PARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINL 353
                     + +   L Q + R F E       L Q+ E+          L  ++ D   
Sbjct: 1449 ---------LEEEQQLRQERHRKFREEEQ----LLQEREE--------QQLHRQERDRKF 1487

Query: 354  LPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKL----QQYKFKARELDP 409
            L  +  + +  RD        K R + +  +       EE ++L    +Q KF   E   
Sbjct: 1488 LEEEQQLRRQERD-------RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540

Query: 410  RILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILED 469
            R  E G    +    K   E        E+++  +E  +K   E  +   +    K +ED
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 470  VVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEE---EDEPVVIKAQPVPHYGVPFKPQ 526
               +  ++             L+       +EDE+   E E   +  Q      +  +PQ
Sbjct: 1601 EQQLRRQEGQQ---------QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651

Query: 527  IPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKN 586
            +      +         D++R+ ++E+++  LQ+GE  + +             E++++ 
Sbjct: 1652 LRRQEREQQL-----RHDRDRKFREEEQL--LQEGEEQQLRRQERDR--KFREEEQQLRR 1702

Query: 587  VTQIEPFCLETD--RRGALKAQTWKHQLEEELRQQKEAACFKA--RPNTVISQEPFVPKK 642
              +   F  E    RR  L+    K + EE+LRQ+ E    +   R   ++ +E   P++
Sbjct: 1703 QERERKFLQEEQQLRRQELER---KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKE 702
            E++ +                 E+  K R+E + R    E Q   Q  + + +EEEQ ++
Sbjct: 1760 EEQQLRR--------------QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805

Query: 703  E 703
            E
Sbjct: 1806 E 1806



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 37/196 (18%), Positives = 89/196 (45%), Gaps = 13/196 (6%)

Query: 541 DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR 600
           +  ++ER+ Q+ K+ +E ++ E    + L L   +     E++ + + + +    E  R 
Sbjct: 465 ERHEQERRKQQLKRDQEEERRE----RWLKLEEEERREQQERREQQLRREQ----EERRE 516

Query: 601 GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
             LK Q  + +L++ LR +++    +      + +     + E++   + L     +   
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576

Query: 661 QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQ-----KKEELARLRRELVHKA 715
           QL   +  + +Q L++   E   Q+ ++ E  RL++EE+     K+EE    RR+ + K+
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636

Query: 716 NPIRKYQGLEIKSSDQ 731
               + +  +++   Q
Sbjct: 637 EEQEERRQQQLRREQQ 652



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 45/198 (22%)

Query: 545  KERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALK 604
            +E QL++E++ ++L + E  +             L E+KV+   Q   F +E +++  L+
Sbjct: 1559 EEEQLRQEREEQQLSRQERDR----------KFRLEEQKVRRQEQERKF-MEDEQQ--LR 1605

Query: 605  AQTWKHQL----------EEELRQQKEAACF--KARPNTVISQEPFVPKKEKKSVAEGLS 652
             Q  + QL          +E+L Q++E      + R    + +EP + ++E++       
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 653  GSLVQEPFQLATEKRAKE------------------RQELEKRMAEVEAQKAQQLEEARL 694
                +E  QL  E   ++                  RQE E++  + E Q  +Q  E + 
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725

Query: 695  QEEEQKKEEL--ARLRRE 710
            +EEEQ ++E    +LRR+
Sbjct: 1726 REEEQLRQETEQEQLRRQ 1743



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 29/141 (20%), Positives = 66/141 (46%), Gaps = 25/141 (17%)

Query: 609 KHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRA 668
           + +LE+  RQ+++   ++ R       + +  ++E+++  E L      E  +   E++ 
Sbjct: 158 QERLEQRDRQRRDEELWRQR-------QEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210

Query: 669 KERQ--ELEKRMAEVEAQKAQQLEEARLQEEEQK----------------KEELARLRRE 710
           + R+  EL ++  E + Q+ ++ ++   QEEE+K                +EE  + +RE
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270

Query: 711 LVHKANPIRKYQGLEIKSSDQ 731
           L  +   +RK +  E++   Q
Sbjct: 271 LQEEEEQLRKLERQELRRERQ 291



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 110/629 (17%), Positives = 254/629 (40%), Gaps = 108/629 (17%)

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKK---MKV 162
            E  + R+   + +RR  +   +K L ++E+   + + +        +++L  ++   ++ 
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355

Query: 163  SNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQEL---EKSM 219
                +K  EE   HQ+   K     ++ + +         ++KFLK  EEQ+L   E+  
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQER-------ERKFLK--EEQQLRCQEREQ 1406

Query: 220  KMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSV-DFHFRTDE---RIKQHPKNQ 275
            +++Q+    RK  EE ++L+     +  ++   QV +   +  F  +E   R ++H K +
Sbjct: 1407 QLRQD--RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464

Query: 276  EEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVP---LAQQVE 332
            EE + +    E + H     R  K     +     +  ++  ++ + +  P     ++ +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDR--KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522

Query: 333  DFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAE 392
              H++   R  L+ ++     L  +    +  +D      + +   +    +  +  E +
Sbjct: 1523 QLHRQQRQRKFLQEEQQ----LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 393  ELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTED 452
               +L++ K + +E + + +E    L ++              E ++++++   +K  ED
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQ--------------EGQQQLRQERDRKFRED 1624

Query: 453  EHF-------EFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEE 505
            E         + H +    K LE+              P+      + ++R        E
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEE-------------PQLRRQEREQQLRHDRDRKFRE 1671

Query: 506  DEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQK-EKKIKELQKGEVP 564
            +E ++               Q  E + +         R++E+QL++ E++ K LQ+ +  
Sbjct: 1672 EEQLL---------------QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716

Query: 565  KFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEE-LRQQKEAA 623
            + + L           E+K +   Q+     ET++    + + ++  LEEE LR ++E  
Sbjct: 1717 RRQEL-----------ERKFREEEQLRQ---ETEQEQLRRQERYRKILEEEQLRPEREEQ 1762

Query: 624  CFKA--RPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEV 681
              +   R      +E    ++E++ +    S    +E  QL      +ER+E + R  + 
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR-----QEREEQQLRPQQR 1817

Query: 682  EAQKAQQLEEARLQEEEQKKEELARLRRE 710
            + +   + E+ +L+E+EQ      RLR+E
Sbjct: 1818 DGKYRWEEEQLQLEEQEQ------RLRQE 1840



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 117/679 (17%), Positives = 267/679 (39%), Gaps = 87/679 (12%)

Query: 78  DNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHH 137
           D  + +E EKE    +++       L+ E         +PQR       Q++L+++E+  
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEE---------EPQR-------QRELQEEEEQL 278

Query: 138 VKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVP 197
            K++ +        +E    +  +    ++K EEE    Q+   +     E+ + R    
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338

Query: 198 CMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKS 257
                +++      EQ+L +  + ++   ++R++ EE ++       Q +++   Q+ + 
Sbjct: 339 LRREQEER-----REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE-QQLRRE 392

Query: 258 VDFHFRTDERIKQHPKNQEEYK---EVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKK 314
                    R +Q  + +++ +   ++    +LR+         K     +     Q  K
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH----EQERREQRLK 448

Query: 315 RTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDD------INLLPSKSSVTKICRDPQ 368
           R  +E    ++   ++ E  H++   +  L+  +++      + L   +    +  R+ Q
Sbjct: 449 REQEER-RDWLKREEETER-HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506

Query: 369 TPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRIL---EGGPILPKKPPVK 425
               Q + R + +  +   E   + L   QQ + +  E   ++L   E   +  ++   +
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566

Query: 426 PPTEPIGFDLEIEKRIQERESK--KKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITV 483
              E      ++ KR +ER  +  K+ ++E  E   +    + LE      ++  L    
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR--LKREE 624

Query: 484 PKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSR 543
           P+      + R ++   E++EE     ++ +         K +  E R  +      +  
Sbjct: 625 PEE-----ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679

Query: 544 DKERQLQKEKK--IKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRG 601
            +E++L +E++   +E  K  +PK++                     Q+E    E D R 
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQ--------------------WQLES---EADARQ 716

Query: 602 ALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQ 661
           + K  +   + E + R+Q++    + R + +  QE     ++++   +    +   +   
Sbjct: 717 S-KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ--- 772

Query: 662 LATEKRAKERQEL-------EKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHK 714
            A EK  + RQ L       E+R  ++ A++ QQ E+  L EEE+K E+  R RRE   +
Sbjct: 773 -AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK-EQRRRQRREREKE 830

Query: 715 ANPIRKYQGLEIKSSDQPL 733
              + + + L+ +   Q L
Sbjct: 831 LQFLEEEEQLQRRERAQQL 849



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 21/56 (37%), Positives = 33/56 (58%), Gaps = 5/56 (8%)

Query: 655 LVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRE 710
           L +EP Q     R ++RQE E+ +AE E Q  +Q E    ++ +++ EEL R R+E
Sbjct: 129 LEEEPGQR----RRQKRQEQERELAEGEEQSEKQ-ERLEQRDRQRRDEELWRQRQE 179



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 38/201 (18%), Positives = 91/201 (45%), Gaps = 10/201 (4%)

Query: 539  SFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETD 598
            S   RD++ +L+++K  ++ Q+ +  + +           L +++ +   + E    E +
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632

Query: 599  RRGALKAQTWKHQLEEE---LRQQKEAACFKARPNTVISQEPFVPKKEKKSVA-EGLSGS 654
             +   + +  +  LEEE    RQ++E      R      +E  + + E++ +  +     
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692

Query: 655  LVQEPFQLATEKRAK----ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRE 710
              +E  QL  ++R +    E Q+L ++  E + ++ +QL +   QE+ +++E   ++  E
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752

Query: 711  LVHKANPIRKYQGLEIKSSDQ 731
               +  P R+ Q L  +  D+
Sbjct: 1753 --EQLRPEREEQQLRRQERDR 1771



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 39/144 (27%), Positives = 64/144 (44%), Gaps = 15/144 (10%)

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
            E DR+   + Q  + + E++LR Q+    F  R    + QE    ++E++   +   G  
Sbjct: 1768 ERDRKFREEEQLRQEREEQQLRSQESDRKF--REEEQLRQE----REEQQLRPQQRDGKY 1821

Query: 656  VQEPFQLATEKRAKERQELEKRMAEVEAQKAQQ----LEEARLQEEEQKK---EELARLR 708
              E  QL  E++ +  ++   R    E Q A Q     EE  L +EE++K   E   +LR
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR 1881

Query: 709  RELVHK--ANPIRKYQGLEIKSSD 730
             E + +      R  Q  EIKS +
Sbjct: 1882 EEHIRRQQKEEQRHRQVGEIKSQE 1905



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 43/197 (21%), Positives = 85/197 (43%), Gaps = 23/197 (11%)

Query: 545  KERQLQKEKKIKELQKGEVP-KFKALPLPHFDTINL---PEKKVKNVTQIEPFCLETDRR 600
            +E QL +E++ + L++ E   KF+   L H +        E++++   +   F  E  + 
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ- 1398

Query: 601  GALKAQTWKHQL-----------EEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAE 649
              L+ Q  + QL           E++L +Q+    F+     V  QE      E++    
Sbjct: 1399 --LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456

Query: 650  GLSGSLVQEPFQLATEKRAKE--RQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARL 707
                   +E  QL  E+  ++  RQE +++  E E Q  +Q  + + +E+E + +E  R 
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516

Query: 708  ---RRELVHKANPIRKY 721
                 + +H+    RK+
Sbjct: 1517 FLEEEQQLHRQQRQRKF 1533



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 31/139 (22%), Positives = 62/139 (44%), Gaps = 15/139 (10%)

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
            + DR+   + Q  +   E++LR+Q+    F+     +  QE     +E+K          
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE-----RERK---------F 1709

Query: 656  VQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEAR-LQEEEQKKEELARLRRELVHK 714
            +QE  QL  ++  ++ +E E+   E E ++ ++ E  R + EEEQ + E    +     +
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769

Query: 715  ANPIRKYQGLEIKSSDQPL 733
                R+ + L  +  +Q L
Sbjct: 1770 DRKFREEEQLRQEREEQQL 1788


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 128/624 (20%), Positives = 245/624 (39%), Gaps = 62/624 (9%)

Query: 125  SAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNA 184
            S    ++ K +  +K+  K     VI++E   +++ +V+    + EE+ +  ++  E+  
Sbjct: 431  SVSTHIKVKSEEKIKVVEKSEKETVIVEE--QTEETQVTEEVTEEEEKEAKEEEGKEEEG 488

Query: 185  SSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIG 244
               E+A+G       PPA++    ++ E+E +  +K + +     K  E+ +  + A + 
Sbjct: 489  GEEEEAEGGEEETKSPPAEEA---ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545

Query: 245  QPVK-KSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFT-SELRKHPSSPARVTKGCT 302
             P K KS ++         ++ E  K+  K+  E K      S  ++   SPA       
Sbjct: 546  SPEKAKSPAKEEAKSPPEAKSPE--KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS--- 600

Query: 303  IVKPFNLSQGKKRTFDETVSTYVPLAQQVED-FHKRTPNRYHLRSKKDDINLLPSKSSVT 361
               P       K           P+ ++ +     ++P +    +K++  +   +KS   
Sbjct: 601  ---PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657

Query: 362  KICRDPQTPVLQTKHRARAVT-CKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK 420
            +  + P+      K  A++    KS  + EA+  EK +    K     P   +     P 
Sbjct: 658  EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS-PVKEEAKSPEKAKS----PV 712

Query: 421  KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP 480
            K   K P +      E  K  ++ +S  K E +  E    P   K L+  V  PE K   
Sbjct: 713  KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD--VKSPEAKTPA 770

Query: 481  ITVPKSPAFALKNRIRMPTKED----EEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEIC 536
                +SPA     + + P KE+    E+   P+   A+  P   +P K ++      E  
Sbjct: 771  KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK-APEKEIPKKEEVKSPVKEEEK 829

Query: 537  PFSFDSRDKERQLQKEK--------KIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVT 588
            P     ++  ++ ++EK        + K+ +K E PK K  P P  +     EKK     
Sbjct: 830  PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK-KEAPKPKVE-----EKK----- 878

Query: 589  QIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVA 648
              EP  +E  +   ++A+      EE   ++K     K  P  V  +E   PK++ +   
Sbjct: 879  --EP-AVEKPKESKVEAKK-----EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930

Query: 649  EGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLR 708
            +    +  +EP + A +K A   ++      + + +KA++ EE    E + K+++    +
Sbjct: 931  KEPDDAKAKEPSKPAEKKEAAPEKK------DTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984

Query: 709  RELVHKANPIRKYQGLEIKSSDQP 732
                 KA    K    + K S  P
Sbjct: 985  EPSKPKAEKAEKSSSTDQKDSKPP 1008



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 116/600 (19%), Positives = 219/600 (36%), Gaps = 33/600 (5%)

Query: 83   KEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKA 142
            K  EK  +VE+S         + E     +   + + +  +    K+ E  E+   +   
Sbjct: 439  KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 143  KRCATPVIIDEILPSKKMK--VSNNKKKPEEEGSAHQDTAEKNAS--SPEKAKGRHTVPC 198
            +   +P   +   P K+ K  V    K P E  S  ++ A+  A   SPEKAK       
Sbjct: 499  EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558

Query: 199  MPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSV 258
              P + K   S E++E +   +++          EE K  A A   +  K  V +  KS 
Sbjct: 559  KSPPEAK---SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615

Query: 259  DFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFD 318
                     +K+  K+  E K         K  +      K     +  +  + K     
Sbjct: 616  A---EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 319  ETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA 378
            E  S     A+       ++P +     K++  +   +KS V +  + P+      K  A
Sbjct: 673  EAKSP--EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730

Query: 379  RAVT-CKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTE--PIGFDL 435
            +     KS  + EA+  EK +  + KA+ LD +  E     P K   + P +  P     
Sbjct: 731  KTPEKAKSPVKEEAKSPEKAKSPE-KAKTLDVKSPEAKT--PAKEEARSPADKFPEKAKS 787

Query: 436  EIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRI 495
             +++ ++  E  K    E  +   +  P K         E+K   + V + P  A + + 
Sbjct: 788  PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847

Query: 496  RMPTKEDEEED---EPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKE 552
                K +E++D   E    K  P P      +P + + +  ++     ++ DK++    E
Sbjct: 848  PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907

Query: 553  KKIK---ELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWK 609
            K+     E+++   PK K           + +K+  +    EP      +  A + +  K
Sbjct: 908  KEAPAKVEVKEDAKPKEKT---------EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958

Query: 610  HQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAK 669
             +  ++  ++ +        +  +S+EP  PK EK   +        + P +   +K AK
Sbjct: 959  EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 117/520 (22%), Positives = 199/520 (38%), Gaps = 78/520 (15%)

Query: 56  QGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPA 115
           + K+P ++     A V   +   +   +EA+     +      A S  EV++    K+PA
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588

Query: 116 QPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPV--IIDEILPSKKMKVSNNKKKPEEEG 173
           + + +S    A+    +K K  VK +AK  A     + +E     ++K     K P +E 
Sbjct: 589 KEEAKS---PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEE 645

Query: 174 SAHQDTAE----KNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMR 229
           +   + A+    + A SPEKAK         P K    KS  + E +   K +  V E  
Sbjct: 646 AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK---AKSPVKAEAKSPEKAKSPVKEEA 702

Query: 230 KKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRK 289
           K  E+ K         PVK+      K+          +K+  K  E+ K     S +++
Sbjct: 703 KSPEKAK--------SPVKEEAKSPEKA-------KSPVKEEAKTPEKAK-----SPVKE 742

Query: 290 HPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKD 349
              SP +             S  K +T D            V+    +TP +   RS  D
Sbjct: 743 EAKSPEKAK-----------SPEKAKTLD------------VKSPEAKTPAKEEARSPAD 779

Query: 350 DINLLPSKSSVTKICRDPQTPVLQTKHRARA----VTCKSTAELEAEELEKLQQYKFKAR 405
                 +KS V +  + P+      K  A+A    +  K   +   +E EK Q+ K K  
Sbjct: 780 KFP-EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE- 837

Query: 406 ELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTK 465
              P+  E      +K P  P TE    D + E+  ++   K K E++      +P  +K
Sbjct: 838 --PPKKAE-----EEKAPATPKTEE-KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889

Query: 466 ILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKP 525
           +        +KK +P    ++PA       ++  KED +  E   + A+  P      +P
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPA-------KVEVKEDAKPKEKTEV-AKKEPDDAKAKEP 941

Query: 526 QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPK 565
             P A   E  P   D+++++ +  +EK   E +  E  K
Sbjct: 942 SKP-AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDK 980



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 45/185 (24%), Positives = 68/185 (36%), Gaps = 49/185 (26%)

Query: 58   KTPLRKANLQQAIVTPL------KPVDNTYYKEAEKENLVEQSIPS------NACSSLEV 105
            K P +KA  ++A  TP          +    KEA K  + E+  P+      +   + + 
Sbjct: 836  KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMK------AKRCATPVIIDEILPSKK 159
            EA   +K P   +    ++  ++D + KEK  V  K      AK  + P    E  P KK
Sbjct: 896  EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955

Query: 160  MKVSNNKKKPEE----EGSAHQD---------------------TAEKNASSPE------ 188
                   KKPEE    E  A +D                     T +K++  PE      
Sbjct: 956  DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015

Query: 189  KAKGR 193
             AKG+
Sbjct: 1016 AAKGK 1020



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 48/232 (20%), Positives = 92/232 (39%), Gaps = 42/232 (18%)

Query: 63  KANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSL 122
           K+ L++    P K +     KE  K  + E+  P         + A   K PA P+    
Sbjct: 800 KSPLKEDAKAPEKEIPK---KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856

Query: 123 RLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEK 182
           + S +++  +KE    K++ K+         +   K+ KV   K++ E++         K
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPA------VEKPKESKVEAKKEEAEDK---------K 901

Query: 183 NASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAG 242
              +PEK           PAK +  +  + +E  +  K + +  + ++ ++  +K   A 
Sbjct: 902 KVPTPEKEA---------PAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA- 951

Query: 243 IGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSP 294
              P KK   +            ++ ++ PK + + KE + T  L K PS P
Sbjct: 952 ---PEKKDTKE---------EKAKKPEEKPKTEAKAKEDDKT--LSKEPSKP 989


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 144/646 (22%), Positives = 237/646 (36%), Gaps = 123/646 (19%)

Query: 76    PVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEK 135
             PV+ T  +E E+E + E+ IP    S  EVE     + P             K    +  
Sbjct: 10234 PVEVT--EEPEEEPISEEEIPEEPPSIEEVEEVAPPRVP----------EVIKKAVPEAP 10281

Query: 136   HHVKMKAKRCATPVIIDEILPSKKMKVSNNKKK--PEEEGSAHQDTAEKNASSPEKAKGR 193
               V  K +  A P  + + +P +K+ V   KK+  P +     +   EK    P+K    
Sbjct: 10282 TPVPKKVE--APPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKK---- 10335

Query: 194   HTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQ 253
                  +PPAK + +      E + S+  +QEVV   +   E            V+  V +
Sbjct: 10336 ---EAVPPAKGRTV-----LEEKVSVAFRQEVVVKERLELEV-----------VEAEVEE 10376

Query: 254   VTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKH-PSSPARVTKGCTIVKPFNLSQG 312
             + +  +FH   +E  +     + E+ EV    +L +H      RV K   +++ F     
Sbjct: 10377 IPEEEEFH-EVEEYFE-----EGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFE---- 10426

Query: 313   KKRTFDETVSTYVPLAQQVEDFHK-RTP------NRYHLRSKKDDINLLPSKSSVTKICR 365
                            A++VE F K + P      +   +  KK    ++P K    K+  
Sbjct: 10427 ---------------AEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPE 10471

Query: 366   DPQTPVLQTKHRA----RAVTCKSTAELEAEEL---EKLQQYKFKARELDPRILEGGP-- 416
              P+  V++ K R     R    K    L  +E+   +K+     K  E  P  +   P  
Sbjct: 10472 VPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKE 10531

Query: 417   ILP-KKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPE 475
             ++P KK PV PP +P     ++ +  +    +KK  +        P P         VPE
Sbjct: 10532 VVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPE 10591

Query: 476   KKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEI 535
             KKV P   PK P          P K  E   E V  K  PVP    P KP++P  +  E+
Sbjct: 10592 KKV-PAAPPKKPEVT-------PVKVPEAPKEVVPEKKVPVP---PPKKPEVPPTKVPEV 10640

Query: 536   CPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
                +   +     +  + +    +  E P+  AL  P  + +  PE        + P   
Sbjct: 10641 PKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPP--- 10697

Query: 596   ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK---EKK------S 646
                              ++ + ++K  A    +P     + P VPK+   EKK       
Sbjct: 10698 -----------------KKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPK 10740

Query: 647   VAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEV-EAQKAQQLEE 691
               E     + + P ++  EK+    ++ E   A+V E  K   LEE
Sbjct: 10741 KPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEE 10786



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 139/700 (19%), Positives = 255/700 (36%), Gaps = 144/700 (20%)

Query: 127  QKDLEQKEKHHVKMKAKRCATPVIIDEI-------------LPSK----KMKVSNNKKKP 169
            QK++  +EK HV + +KR   P  + E+             +P K      KV    KKP
Sbjct: 9265 QKEIVTEEKIHVAI-SKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKP 9323

Query: 170  EEEGSAHQDTAEKNASSPEKAKGRHTVPC------MPPAKQKFLKSTEEQELEKSMKMQQ 223
              E        +K  ++P K       P       +P AK+K     +  E++K +  ++
Sbjct: 9324 VPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEE 9383

Query: 224  EVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQE------- 276
            ++  + ++ E         + +  KK V +  K V    R +E +   PK          
Sbjct: 9384 KITIVTQREES----PPPAVPEIPKKKVPEERKPVP---RKEEEVPPPPKVPALPKKPVP 9436

Query: 277  EYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHK 336
            E K        +K P   A V+K   +       + K+   +E +S  VP   +V     
Sbjct: 9437 EEKVAVPVPVAKKAPPPRAEVSKKTVV-------EEKRFVAEEKLSFAVPQRVEVTRHEV 9489

Query: 337  RTPNRYHLRSKKDDINLL---------PSKSSVTK--ICRDPQTPVLQTKHRARAVTCKS 385
                 +    +++ +++            ++ VT+  +  +P+  V++ K          
Sbjct: 9490 SAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHI----ISK 9545

Query: 386  TAELEAEELEKLQQYKFKARELDPRILEGGP----------ILPKK------------PP 423
              E E  E+ + Q+ K   +   P  +E  P          I+P+K            PP
Sbjct: 9546 RVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPP 9605

Query: 424  VKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILED----------VVGV 473
             K P EP       +K + E++   K           P P K+ E           +V V
Sbjct: 9606 PKVPEEP-------KKPVPEKKVPPKVIKME-----EPLPAKVTERHMQITQEEKVLVAV 9653

Query: 474  PEKKVLP-ITVPKSPAFALKNRIRMPTKEDEEEDEPV--------VIKAQPVPHYGVPFK 524
             +K+  P   VP+ P  A+     +  K   EE+ P         V+K + V       +
Sbjct: 9654 TKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKRE 9713

Query: 525  PQ-IPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKAL-PLPHFDTIN-LPE 581
            PQ I E   +E    ++   ++   +Q+E++ +E ++ +  +F+   P   +D      E
Sbjct: 9714 PQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEE 9773

Query: 582  KKVKNVTQIEPFCLETDRRGALK---------------AQTWKHQLEEELRQQKEAACFK 626
            ++ +   + E +  E ++   +K               A+  K  + EE          K
Sbjct: 9774 REYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLK 9833

Query: 627  ARPNTVISQEP----------FVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEK 676
              P  V  +EP           + K+EK+ V E  +   ++    +A EK    R+E+  
Sbjct: 9834 PPPPKV-PEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAP 9892

Query: 677  RMAEVEAQKAQQLEEARLQEE--EQKKEELARLRRELVHK 714
             +   E  K  + EE   +EE     +E L     E +H+
Sbjct: 9893 PVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHE 9932



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 99/461 (21%), Positives = 167/461 (36%), Gaps = 66/461 (14%)

Query: 148   PVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFL 207
             P  + E+LP K+  V   KK P       +    K   +P++      VP +PP K+  +
Sbjct: 10492 PTKVPEVLPPKE--VVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVP-VPPPKKPEV 10548

Query: 208   KSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQ---PVKKSVSQVTKSVDFHFRT 264
               T+  E+ K+   +++V E      E     +    +   P KK  +   K  +    T
Sbjct: 10549 PPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEV---T 10605

Query: 265   DERIKQHPKNQEEYKEVNFTSELRKH--PSSPARVTKGCTIVK------PFNLSQGKKRT 316
               ++ + PK     K+V      +    P+    V K     K      P          
Sbjct: 10606 PVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEV 10665

Query: 317   FDET--VSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQT 374
             F+E   V+   P A+ VE+     P +  +  KK     +P K +   + + P+ P ++ 
Sbjct: 10666 FEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKP----VPEKKAPAVVAKKPELPPVKV 10721

Query: 375   KHRARAVTCKSTAELEAEELEKLQQYKFKA--RELDPRILEGGPILPKKPPVKPPTEPIG 432
                 + V  +    L   +  +    K     +E+ P      P  P+ PP K P  P  
Sbjct: 10722 PEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKK 10781

Query: 433   FDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKIL--EDVVGVP-----EKKVLPITVPK 485
               LE +  +   E  +    E +E      P + +  E+   VP     E +V P  VP+
Sbjct: 10782 PVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPE 10841

Query: 486   SPAFALKNR----IRMPTKEDEEEDEPVVIKAQP-------------------------- 515
              P   +  +    I+ P     +E EP  +  +P                          
Sbjct: 10842 EPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLK 10901

Query: 516   -VPHYGVPFKPQIPEARTVEICPFSFDSRDKE-RQLQKEKK 554
              +P   VP KPQ+PE   VE+ P      +K+ R+L  E+K
Sbjct: 10902 AIPKKKVPEKPQVPE--KVELTPLKVPGGEKKVRKLLPERK 10940



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 146/664 (21%), Positives = 238/664 (35%), Gaps = 117/664 (17%)

Query: 86    EKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRC 145
             EK+ +++  IP+      ++E     K P  P++          + +KEK       +  
Sbjct: 9559  EKKIVLKPKIPA------KIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEP 9612

Query: 146   ATPVIIDEILPSK-KMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA-- 202
               PV   ++ P   KM+     K  E      Q+     A + ++A  +  VP  P    
Sbjct: 9613  KKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAV 9672

Query: 203   -KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIG---QPVKKSVSQVTKSV 258
              ++K LK   ++E E   K    V E RK+  + +K+++       QP+K+      K  
Sbjct: 9673  PEEKVLKLKPKREEEPPAK----VTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKER 9728

Query: 259   DFHFRTDERIKQHPKNQEEYKEVNF--------TSELRKHPSSPARVTKGCTIVKPFNLS 310
              +    +    Q  +  EEY+E ++        T E  ++     R  +     + +   
Sbjct: 9729  AYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITE 9788

Query: 311   QGK----KRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRD 366
               K    K   +E V T  P A   +   K  P        ++ + +   K       + 
Sbjct: 9789  PEKPIPVKPVPEEPVPTK-PKAPPAKVLKKAVP--------EEKVPVPIPKKLKPPPPKV 9839

Query: 367   PQTPVLQTKHRARAVTCKSTAELEAEELEK--LQQYKFKARELDPRILEGGPILPKK--- 421
             P+ P    + + R    K   E   E   K  ++  +  A E  P        +P+K   
Sbjct: 9840  PEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVP--------VPRKEVA 9891

Query: 422   PPVKPPTEP-------IGFDLEI----EKRIQERESKKKTEDEHFEFHSRPCPTKILEDV 470
             PPV+ P  P       + F+ E+    E+ + E E +   E+E F       P       
Sbjct: 9892  PPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVI----P 9947

Query: 471   VGVPEKKVLPITVPKSPAFALKNRIRMPTKEDE-----EEDEPVVI----KAQPVPHYGV 521
             V VPE    P+   K P    K +   P K  E     EE  PV+I    K  P     V
Sbjct: 9948  VKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEV 10007

Query: 522   PFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPE 581
             P KP +PE +     P   ++           K+ E+ K  VP+ K +P+P    +  P 
Sbjct: 10008 PKKP-VPEEKVPVPVPKKVEA--------PPAKVPEVPKKPVPE-KKVPVPAPKKVEAPP 10057

Query: 582   KKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPK 641
              KV  V                     K  + EE +           P  V +  P VPK
Sbjct: 10058 AKVPEVP--------------------KKLIPEEKKPTPV-------PKKVEAPPPKVPK 10090

Query: 642   KEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL--EKRMAEVEAQKAQQLEEARLQEEEQ 699
             K +      +  +L QE   L  E+   E + L  E+ +   E +   + EE   +EEE 
Sbjct: 10091 KRE---PVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEI 10147

Query: 700   KKEE 703
               EE
Sbjct: 10148 PPEE 10151



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 123/593 (20%), Positives = 225/593 (37%), Gaps = 108/593 (18%)

Query: 201  PAKQKFLKSTEEQELEK-SMKMQQEVVEMRKKNEEFKKLALAGIGQ-PVKKSVSQV---- 254
            P   K +K    +++EK S +M++E V++ K  E  KK+      + PV++ V +V    
Sbjct: 9175 PPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPA 9234

Query: 255  ---------TKSVDFHFRTDERIK-QHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIV 304
                      + + F   T+E +    P+ Q+E       +E + H +   RV       
Sbjct: 9235 VHTKKMVISEEKMFFASHTEEEVSVTVPEVQKE-----IVTEEKIHVAISKRVE------ 9283

Query: 305  KPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPN--RYHLRSKKDDINLLPSK--SSV 360
             P  + +  ++   E V+  VP+ ++VE    + P   +  +  +K  +  +P K  ++ 
Sbjct: 9284 PPPKVPELPEKPAPEEVAP-VPIPKKVEPPAPKVPEVPKKPVPEEKKPVP-VPKKEPAAP 9341

Query: 361  TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK 420
             K+   P+ PV + K        K     +  E++K    + K   +  R     P +P+
Sbjct: 9342 PKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPE 9401

Query: 421  KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP 480
             P  K P E         K +  +E +     +      +P P + +   V V +K   P
Sbjct: 9402 IPKKKVPEE--------RKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPP 9453

Query: 481  --------------ITVPKSPAFALKNRI---------------------------RMPT 499
                              +  +FA+  R+                           R   
Sbjct: 9454 RAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEE 9513

Query: 500  KEDEEEDEPVVIKAQPVP-HYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEK----- 553
            +E+EEE E    +    P  Y V  K  I   R VE  P     R +++ + K K     
Sbjct: 9514 REEEEEAEVTEYEVMEEPEEYVVEEKLHIISKR-VEAEPAEVTERQEKKIVLKPKIPAKI 9572

Query: 554  ------KIKELQKGEVPKFKA-LPLPHFDTI---NLPEKKVKNVTQ--IEPFCLETDRRG 601
                  K+ E  K  VP+ K   P+P  + +    +PE+  K V +  + P  ++ +   
Sbjct: 9573 EEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPL 9632

Query: 602  ALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQ 661
              K      Q+ +E +        +A P   + +EP     E+K +   L     +EP  
Sbjct: 9633 PAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLK--LKPKREEEPPA 9690

Query: 662  LATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQK----KEELARLRRE 710
              TE R +  +E EK   E   ++ Q ++E  + EE+++    +EE   ++RE
Sbjct: 9691 KVTEFRKRVVKE-EKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQRE 9742



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 69/297 (23%), Positives = 110/297 (37%), Gaps = 32/297 (10%)

Query: 461  PCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYG 520
            P P K+      VPE    P+   K P    K     P K  E   +PV  +  PVP   
Sbjct: 9304 PIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP--- 9360

Query: 521  VPFKPQIPEARTVEICPFSFDSRDKERQLQKEKK----IKELQKGEVPKFKALPLPHFD- 575
            V  K + P A+  E+              Q+E+     + E+ K +VP+ +  P+P  + 
Sbjct: 9361 VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPE-ERKPVPRKEE 9419

Query: 576  -------TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKAR 628
                      LP+K V       P  +   +    +A+  K  + EE R   E     A 
Sbjct: 9420 EVPPPPKVPALPKKPVPEEKVAVPVPV-AKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAV 9478

Query: 629  PNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQ 688
            P  V      V  +E+ S +E   G  +     +  E+  +E +E E    EV  +  + 
Sbjct: 9479 PQRVEVTRHEVSAEEEWSYSEEEEGVSI----SVYREEEREEEEEAEVTEYEVMEEPEEY 9534

Query: 689  LEEARL-----QEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPK 740
            + E +L     + E +  E   R  +++V K     K +         P  VP +PK
Sbjct: 9535 VVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIE------EPPPAKVPEAPK 9585



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 147/714 (20%), Positives = 270/714 (37%), Gaps = 107/714 (14%)

Query: 84    EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQR---------RSLRLSAQKDLEQKE 134
             EA K+ + E+ +P+      +V      K P +P++         + +++      +  E
Sbjct: 9582  EAPKKIVPEKKVPAPVPKKEKVPPP---KVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTE 9638

Query: 135   KHHVKMKAKRCATPVIIDEILPSKKM-----------KVSNNKKKPEEEGSAHQDTAEKN 183
             +H    + ++    V   E  P  ++           KV   K K EEE  A      K 
Sbjct: 9639  RHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKR 9698

Query: 184   ASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGI 243
                 EK       P   P   K +   EE+E   +++ +   V+  ++ EE+++      
Sbjct: 9699  VVKEEKVSIE--APKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEF 9756

Query: 244   GQPVKKSVSQVTKSVDFHFRTDERIKQH------PKNQEEYKEVNFTSELRKHPSSPARV 297
              +   +   +  +  ++  R  ER ++H      P+     K V       K  + PA+V
Sbjct: 9757  EE--YEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKV 9814

Query: 298   TKGCTIVK-------------PFNLSQGKKRTFDETVSTYVPLAQ--QVEDFHKRTPNRY 342
              K     +             P  + +  K+ F+E +   +   +  QV +   + P + 
Sbjct: 9815  LKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKP 9874

Query: 343   HLRSKKDDINLLPSKSSVTKICRDPQTPVL----QTKHRARAVTCKSTAELEAEELEKLQ 398
                  ++ + +   +  V    R P+ P      +       VT      +E EE    +
Sbjct: 9875  KRVVAEEKVPV--PRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHE 9932

Query: 399   QYKF-KARELDPRILEGGPILPKKP------PVKPPTE---PIGFDLEIEKRIQERESKK 448
             + +F    E+ P I    P +P+KP      PV  P +   P     E+ K+ +E+    
Sbjct: 9933  EEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVL 9992

Query: 449   KTEDEHFEFHSRPCPTKILE-DVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDE 507
               + E      +P P K+ E     VPE+KV P+ VPK            P K  E   +
Sbjct: 9993  IPKKE------KPPPAKVPEVPKKPVPEEKV-PVPVPKKVEAP-------PAKVPEVPKK 10038

Query: 508   PVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFK 567
             PV  K  PVP    P K + P A+  E+         K   + K+    E    +VPK K
Sbjct: 10039 PVPEKKVPVP---APKKVEAPPAKVPEVPKKLIPEEKKPTPVPKK---VEAPPPKVPK-K 10091

Query: 568   ALPLPHFDTINLP-EKKVKNVTQIEP--FCLETDRRGALKAQTWKHQLEEELRQQKEAAC 624
               P+P    + LP E++V    +I P    L  +     + +    + EE L +++E   
Sbjct: 10092 REPVP--VPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEE--- 10146

Query: 625   FKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQ 684
                    V  +E +VP++E+    E +   +  +    A     K++   +K    V   
Sbjct: 10147 IPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKK----VVIP 10202

Query: 685   KAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVS 738
             K ++   A++ E  +K EE    +R ++ K   +     L ++ +++P   P+S
Sbjct: 10203 KKEEAPPAKVPEVPKKVEE----KRIILPKEEEV-----LPVEVTEEPEEEPIS 10247



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 13/99 (13%)

Query: 436  EIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRI 495
            E E+  QERE  +  ++ + E H R  P K       VPEKK  P   PK     +  +I
Sbjct: 9139 EWEEAYQEREVIQVQKEVYEESHERKVPAK-------VPEKKAPP--PPKVIKKPVIEKI 9189

Query: 496  RMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVE 534
               ++  EEE     ++   VP       PQ P    V+
Sbjct: 9190 EKTSRRMEEEK----VQVTKVPEVSKKIVPQKPSRTPVQ 9224


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 85/407 (20%), Positives = 163/407 (40%), Gaps = 69/407 (16%)

Query: 336 KRTPNRYHLRSKKDDINL--------LPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTA 387
           +R   +  LR K+++ +L        + +++SV        T   Q +    A   +  A
Sbjct: 42  RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101

Query: 388 ELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESK 447
             E    ++LQ+   + +E DP I +    LP +                E    E+E K
Sbjct: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA---------ENETTEKEEK 152

Query: 448 KKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDE 507
            ++  E +E       TK  +                     A +N+     KE+EEE++
Sbjct: 153 SESRQERYEIEETETVTKSYQ---------------KNDWRDAEENKKEDKEKEEEEEEK 197

Query: 508 PVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEV---- 563
           P               +  I E   VE+        +K  + Q+E  +  L+ G++    
Sbjct: 198 PK--------------RGSIGE-NQVEVM-----VEEKTTESQEETVVMSLKNGQISSEE 237

Query: 564 PKFKALPLPHFDTINLPEK---KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR-QQ 619
           PK +       D I+  EK   + K   + E   LE + R  +KA+  K   +E  R + 
Sbjct: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297

Query: 620 KEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEK--- 676
           +E A  + R      +   + ++EK++  E      ++E  + A E+R + ++E ++   
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEE---RQRIKEEEKRAAEERQRIKEEEKRAAE 354

Query: 677 ---RMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK 720
              R+ E E + A++ + AR +EEE+ K E  +  ++L  K + +++
Sbjct: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQE 401



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 129/648 (19%), Positives = 252/648 (38%), Gaps = 99/648 (15%)

Query: 83  KEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQ----PQRRSLRLSAQKDLEQKEKHHV 138
           +E E    V   +  NA +S+  E A +  T  Q     +   L   A+++  ++++   
Sbjct: 54  QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113

Query: 139 KMKAKRCATPVIIDEIL--PSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTV 196
            ++ ++   P I D  L  PS++M          +  +A  +T EK   S E  + R+ +
Sbjct: 114 ALERQKEFDPTITDASLSLPSRRM----------QNDTAENETTEKEEKS-ESRQERYEI 162

Query: 197 PCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPV------KKS 250
                  + + K+ + ++ E++ K  +E     K+ EE +K     IG+        +K+
Sbjct: 163 EETETVTKSYQKN-DWRDAEENKKEDKE-----KEEEEEEKPKRGSIGENQVEVMVEEKT 216

Query: 251 VSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLS 310
                ++V    +  +   + PK +EE ++ +   E+  H        +     +    +
Sbjct: 217 TESQEETVVMSLKNGQISSEEPKQEEEREQGS--DEISHHEKMEEEDKERAEAERARLEA 274

Query: 311 QGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTP 370
           + ++R   E          ++E   K        R  ++   +           R+ +  
Sbjct: 275 EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM-----------REEEKR 323

Query: 371 VLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEP 430
             + + R      K   +  AEE +++++ + +A E   RI E      ++       E 
Sbjct: 324 AAEERQRI-----KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378

Query: 431 IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFA 490
               +E +KR ++ E KK    E          TKI  + V   E+K+    V +  A  
Sbjct: 379 EKAKVEEQKRNKQLEEKKHAMQE----------TKIKGEKV---EQKIEGKWVNEKKAQE 425

Query: 491 LKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQ 550
            K +  +  K+ EE+   V  K + +      FK +  E +  +I        + +  + 
Sbjct: 426 DKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE--EIKDEKIKKDKEPKEEVKSFMD 483

Query: 551 KEKKIKELQKGEVPKFKALPLPHFD-TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWK 609
           ++K   E+ K +  +F    L H + T + P  +    T+        +  GA + +  K
Sbjct: 484 RKKGFTEV-KSQNGEFMTHKLKHTENTFSRPGGRASVDTK--------EAEGAPQVEAGK 534

Query: 610 HQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAK 669
            +LEE  R++ E              E F   K+K            Q+   L  E+  K
Sbjct: 535 -RLEELRRRRGET-----------ESEEFEKLKQK------------QQEAALELEELKK 570

Query: 670 ERQELEKRMAEVEAQKAQQLEEARLQEEEQK---KEELARLRRELVHK 714
           +R+E  K + E E ++ Q+  + +L+EEE+K   KEE+ R R E   K
Sbjct: 571 KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 618



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 93/507 (18%), Positives = 193/507 (38%), Gaps = 62/507 (12%)

Query: 24  DEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKP---VDNT 80
           +E   ++ +   EE+   +   +G+N    + + KT     + ++ +V  LK        
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTT---ESQEETVVMSLKNGQISSEE 237

Query: 81  YYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD---------LE 131
             +E E+E   ++          + E A + +   + + R  R+ A++D         +E
Sbjct: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE-RIKAEQDKKIADERARIE 296

Query: 132 QKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAK 191
            +EK   + + +R A     + +   +K      ++  EEE  A ++           A+
Sbjct: 297 AEEKAAAQERERREAEER--ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354

Query: 192 GRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSV 251
            R  +      K++  ++ EE++  ++ + ++  VE +K+N++ ++          KK  
Sbjct: 355 ERQRI------KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEE----------KKHA 398

Query: 252 SQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQ 311
            Q TK      + +++I+    N+++ +E    + + K         KG  +       Q
Sbjct: 399 MQETKIKG--EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE----EKGTKVQAKREKLQ 452

Query: 312 GKKRTF------DETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICR 365
             K TF      DE +       ++V+ F  R      ++S+  +      K +     R
Sbjct: 453 EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 512

Query: 366 DPQTPVLQTKHRARAVTCKS----------TAELEAEELEKLQQYKFKARELDPRILEGG 415
                 + TK    A   ++            E E+EE EKL+Q   K +E    + E  
Sbjct: 513 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ---KQQEAALELEELK 569

Query: 416 PILPKKPPVKPPTEPIGFDLEIEKRIQERESKK--KTEDEHFEFHSRPCPTKILEDVVGV 473
               ++  V    E      E +++++E E K+  K E E     +     K+ ED +  
Sbjct: 570 KKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS- 628

Query: 474 PEKKVLPITVPKSPAFALKNRIRMPTK 500
            +KK      PK  +  ++ R     K
Sbjct: 629 DDKKPFKCFTPKGSSLKIEERAEFLNK 655



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 29/146 (19%), Positives = 68/146 (46%), Gaps = 10/146 (6%)

Query: 596 ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLS--- 652
           E  +RG++     +  +EE+  + +E     +  N  IS E    ++E++  ++ +S   
Sbjct: 196 EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHE 255

Query: 653 -------GSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELA 705
                       E  +L  E+R + + E +K++A+  A+   + + A  + E ++ EE  
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315

Query: 706 RLRRELVHKANPIRKYQGLEIKSSDQ 731
           R+R E    A   ++ +  E +++++
Sbjct: 316 RMREEEKRAAEERQRIKEEEKRAAEE 341


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 151/701 (21%), Positives = 260/701 (37%), Gaps = 115/701 (16%)

Query: 67   QQAIVTPLKPVDNTYYKEAEKENLVEQSIPSN--------------ACSSLEVEAAI--- 109
            QQ     LK ++  + +  E++NL+++ + +               A    E+E  +   
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 110  --------SRKTPAQPQRRSLR---LSAQKDLEQKEKHHVKMKAKRCATPVII----DEI 154
                     R    Q +R+ +    L  ++ LE++E    K++ ++      I    DEI
Sbjct: 928  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987

Query: 155  L--PSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEE 212
            L    +  K+S  +K  EE  S   D     A   EKAK    +      K + + S  E
Sbjct: 988  LVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLK----NKHESMISELE 1040

Query: 213  QELEKSMKMQQEVVEMRKKNE----EFKKLALAGIGQPVKKSVSQVTKSVD----FHFRT 264
              L+K  K +QE+ ++++K E    +F +  +A +   + +   Q+ K  +       R 
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 265  DERIKQHPKNQEEYKEVN-FTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVST 323
            D+ I Q     ++ +E+    S+L++   S              N ++ +KR   E +  
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR---------NKAEKQKRDLGEELEA 1150

Query: 324  YVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTC 383
               L  ++ED    T  +  LR+K++       + +V K   D +T      H A+    
Sbjct: 1151 ---LKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEET----RSHEAQVQEM 1197

Query: 384  KSTAELEAEEL-EKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRI- 441
            +       EEL E+L+Q+K     LD                K   E    DL  E R+ 
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKN--------------KQTLEKENADLAGELRVL 1243

Query: 442  ----QERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRM 497
                QE E KKK  +   +     C         G   +  L   V K     L+N +  
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSD-------GERARAELNDKVHK-----LQNEVES 1291

Query: 498  PTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKE 557
             T    E +   +  A+ V    +  + Q  +    E      +   K RQL++E+   +
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVA--SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 558  LQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR 617
             Q  E  + K     H  T+N+     K   Q     +E    G  + Q     L ++  
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 618  QQKEAACFKARPNTVISQE---PFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL 674
            ++  A     +    + QE     V    ++ +   L     +    LA EK    +   
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 675  EKRMAEVEAQ----KAQQLEEARLQEEEQKKEELARLRREL 711
            E+  AE EA+    KA  L  A L+E  + KEEL R  + L
Sbjct: 1470 ERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKML 1509



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/204 (25%), Positives = 94/204 (46%), Gaps = 37/204 (18%)

Query: 545  KERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALK 604
            KE +LQK K+ ++  + E+ + +       +  NL +++++  T++     E   R A K
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 605  AQTWKHQL--------EEELRQQKEAACFKARPNTVISQEPFVPKKE--------KKSVA 648
             Q  +  L        EEE R Q+  A  K     ++  E  + ++E        +K  A
Sbjct: 917  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 649  EGLSGSLVQEPFQLATE--KRAKERQELEKRMAEV------EAQKAQQLE---------- 690
            E     L  E   +  +  K +KER+ LE+R++++      E +KA+ L           
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036

Query: 691  ---EARLQEEEQKKEELARLRREL 711
               E RL++EE+ ++EL +L+R+L
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKL 1060



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 11/119 (9%)

Query: 612  LEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKER 671
            L EE  + K     K +  ++IS+     KKE+KS          ++  +    K   + 
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----------RQELEKLKRKLEGDA 1064

Query: 672  QELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSD 730
             +  +++A+++AQ A+ L+    ++EE+ +  LARL  E+  K N ++K + LE   SD
Sbjct: 1065 SDFHEQIADLQAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 79/367 (21%), Positives = 155/367 (42%), Gaps = 39/367 (10%)

Query: 375  KHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV--KPPTEPIG 432
            K     +  +  A LE EE ++ QQ + + +++  ++L+    L ++     K   E + 
Sbjct: 917  KQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 433  FDLEIEKR------IQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKS 486
             + +I+K       + ++ +K   E +  E       T + E+     E+K   +T  K+
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKN 1030

Query: 487  PAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKE 546
               ++ + + +  K++E+  + +    + +      F  QI + +  +I         KE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKE 1089

Query: 547  RQLQKE---------------KKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIE 591
             +LQ                 KKI+EL+ G +   +          N  EK+ +++ + E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELE-GHISDLQEDLDSERAARNKAEKQKRDLGE-E 1147

Query: 592  PFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKK--SVAE 649
               L+T+    L +   + +L  + R+Q+     KA      S E  V +  +K     E
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAK-REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 650  GLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRR 709
             L+  L  E F+ A     K +Q LEK  A++ A + + L +A+ QE E KK++L    +
Sbjct: 1207 ELTEQL--EQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAK-QEVEHKKKKLEAQVQ 1262

Query: 710  ELVHKAN 716
            EL  K +
Sbjct: 1263 ELQSKCS 1269



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 78/408 (19%), Positives = 149/408 (36%), Gaps = 57/408 (13%)

Query: 309  LSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINL-LPSKSSVTKICRDP 367
            L +GKKR   E  +      ++   + K    +  L+ + DD+ + L ++  +       
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 368  QTPVLQTKHRARAVTCKSTAE---LEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV 424
            Q    Q     + ++ K   E    EAE  EK  +    AR L+  +     +      +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 425  KPPTEP-IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITV 483
            K   E  +    ++ K + E E  K+  +   E        + LED +   E   L + V
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLEELEDELQATEDAKLRLEV 1567

Query: 484  PKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSR 543
                  ALK +     +  +E++E    + Q   H                   +  +  
Sbjct: 1568 NMQ---ALKGQFERDLQARDEQNEEKRRQLQRQLH------------------EYETELE 1606

Query: 544  DKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGAL 603
            D+ +Q       K+  +G++   K L L     I   E+ +K + +++            
Sbjct: 1607 DERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQA----------- 1652

Query: 604  KAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLA 663
                   Q+++  R+ ++A   +         E F   KE +  A+ L   L+Q    LA
Sbjct: 1653 -------QMKDFQRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 664  TEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRREL 711
              +RA+++ +LEK     E   +     A   E+ + +  +A+L  EL
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 12/108 (11%)

Query: 613 EEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQ 672
           +EE  Q KE    K +     ++      ++K S       +L+QE  Q  TE  A E +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYA-EAE 907

Query: 673 ELEKRMAEVEAQKAQQLEE------ARLQEEEQKKEELARLRRELVHK 714
           E+  R+A     K Q+LEE      ARL+EEE + ++L   R+++  +
Sbjct: 908 EMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 151/701 (21%), Positives = 260/701 (37%), Gaps = 115/701 (16%)

Query: 67   QQAIVTPLKPVDNTYYKEAEKENLVEQSIPSN--------------ACSSLEVEAAI--- 109
            QQ     LK ++  + +  E++NL+++ + +               A    E+E  +   
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 110  --------SRKTPAQPQRRSLR---LSAQKDLEQKEKHHVKMKAKRCATPVII----DEI 154
                     R    Q +R+ +    L  ++ LE++E    K++ ++      I    DEI
Sbjct: 935  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994

Query: 155  L--PSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEE 212
            L    +  K+S  +K  EE  S   D     A   EKAK    +      K + + S  E
Sbjct: 995  LVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLK----NKHESMISELE 1047

Query: 213  QELEKSMKMQQEVVEMRKKNE----EFKKLALAGIGQPVKKSVSQVTKSVD----FHFRT 264
              L+K  K +QE+ ++++K E    +F +  +A +   + +   Q+ K  +       R 
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 265  DERIKQHPKNQEEYKEVN-FTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVST 323
            D+ I Q     ++ +E+    S+L++   S              N ++ +KR   E +  
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR---------NKAEKQKRDLGEELEA 1157

Query: 324  YVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTC 383
               L  ++ED    T  +  LR+K++       + +V K   D +T      H A+    
Sbjct: 1158 ---LKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEET----RSHEAQVQEM 1204

Query: 384  KSTAELEAEEL-EKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRI- 441
            +       EEL E+L+Q+K     LD                K   E    DL  E R+ 
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKN--------------KQTLEKENADLAGELRVL 1250

Query: 442  ----QERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRM 497
                QE E KKK  +   +     C         G   +  L   V K     L+N +  
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSD-------GERARAELNDKVHK-----LQNEVES 1298

Query: 498  PTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKE 557
             T    E +   +  A+ V    +  + Q  +    E      +   K RQL++E+   +
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVA--SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 558  LQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR 617
             Q  E  + K     H  T+N+     K   Q     +E    G  + Q     L ++  
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 618  QQKEAACFKARPNTVISQE---PFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL 674
            ++  A     +    + QE     V    ++ +   L     +    LA EK    +   
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 675  EKRMAEVEAQ----KAQQLEEARLQEEEQKKEELARLRREL 711
            E+  AE EA+    KA  L  A L+E  + KEEL R  + L
Sbjct: 1477 ERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKML 1516



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/204 (25%), Positives = 94/204 (46%), Gaps = 37/204 (18%)

Query: 545  KERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALK 604
            KE +LQK K+ ++  + E+ + +       +  NL +++++  T++     E   R A K
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 605  AQTWKHQL--------EEELRQQKEAACFKARPNTVISQEPFVPKKE--------KKSVA 648
             Q  +  L        EEE R Q+  A  K     ++  E  + ++E        +K  A
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 649  EGLSGSLVQEPFQLATE--KRAKERQELEKRMAEV------EAQKAQQLE---------- 690
            E     L  E   +  +  K +KER+ LE+R++++      E +KA+ L           
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043

Query: 691  ---EARLQEEEQKKEELARLRREL 711
               E RL++EE+ ++EL +L+R+L
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKL 1067



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 11/119 (9%)

Query: 612  LEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKER 671
            L EE  + K     K +  ++IS+     KKE+KS          ++  +    K   + 
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----------RQELEKLKRKLEGDA 1071

Query: 672  QELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSD 730
             +  +++A+++AQ A+ L+    ++EE+ +  LARL  E+  K N ++K + LE   SD
Sbjct: 1072 SDFHEQIADLQAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 79/367 (21%), Positives = 155/367 (42%), Gaps = 39/367 (10%)

Query: 375  KHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV--KPPTEPIG 432
            K     +  +  A LE EE ++ QQ + + +++  ++L+    L ++     K   E + 
Sbjct: 924  KQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 433  FDLEIEKR------IQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKS 486
             + +I+K       + ++ +K   E +  E       T + E+     E+K   +T  K+
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKN 1037

Query: 487  PAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKE 546
               ++ + + +  K++E+  + +    + +      F  QI + +  +I         KE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKE 1096

Query: 547  RQLQKE---------------KKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIE 591
             +LQ                 KKI+EL+ G +   +          N  EK+ +++ + E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELE-GHISDLQEDLDSERAARNKAEKQKRDLGE-E 1154

Query: 592  PFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKK--SVAE 649
               L+T+    L +   + +L  + R+Q+     KA      S E  V +  +K     E
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAK-REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 650  GLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRR 709
             L+  L  E F+ A     K +Q LEK  A++ A + + L +A+ QE E KK++L    +
Sbjct: 1214 ELTEQL--EQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAK-QEVEHKKKKLEAQVQ 1269

Query: 710  ELVHKAN 716
            EL  K +
Sbjct: 1270 ELQSKCS 1276



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 78/408 (19%), Positives = 149/408 (36%), Gaps = 57/408 (13%)

Query: 309  LSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINL-LPSKSSVTKICRDP 367
            L +GKKR   E  +      ++   + K    +  L+ + DD+ + L ++  +       
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 368  QTPVLQTKHRARAVTCKSTAE---LEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV 424
            Q    Q     + ++ K   E    EAE  EK  +    AR L+  +     +      +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 425  KPPTEP-IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITV 483
            K   E  +    ++ K + E E  K+  +   E        + LED +   E   L + V
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLEELEDELQATEDAKLRLEV 1574

Query: 484  PKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSR 543
                  ALK +     +  +E++E    + Q   H                   +  +  
Sbjct: 1575 NMQ---ALKGQFERDLQARDEQNEEKRRQLQRQLH------------------EYETELE 1613

Query: 544  DKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGAL 603
            D+ +Q       K+  +G++   K L L     I   E+ +K + +++            
Sbjct: 1614 DERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQA----------- 1659

Query: 604  KAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLA 663
                   Q+++  R+ ++A   +         E F   KE +  A+ L   L+Q    LA
Sbjct: 1660 -------QMKDFQRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 664  TEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRREL 711
              +RA+++ +LEK     E   +     A   E+ + +  +A+L  EL
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 12/108 (11%)

Query: 613 EEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQ 672
           +EE  Q KE    K +     ++      ++K S       +L+QE  Q  TE  A E +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYA-EAE 914

Query: 673 ELEKRMAEVEAQKAQQLEE------ARLQEEEQKKEELARLRRELVHK 714
           E+  R+A     K Q+LEE      ARL+EEE + ++L   R+++  +
Sbjct: 915 EMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 151/701 (21%), Positives = 260/701 (37%), Gaps = 115/701 (16%)

Query: 67   QQAIVTPLKPVDNTYYKEAEKENLVEQSIPSN--------------ACSSLEVEAAI--- 109
            QQ     LK ++  + +  E++NL+++ + +               A    E+E  +   
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 110  --------SRKTPAQPQRRSLR---LSAQKDLEQKEKHHVKMKAKRCATPVII----DEI 154
                     R    Q +R+ +    L  ++ LE++E    K++ ++      I    DEI
Sbjct: 935  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994

Query: 155  L--PSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEE 212
            L    +  K+S  +K  EE  S   D     A   EKAK    +      K + + S  E
Sbjct: 995  LVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLK----NKHESMISELE 1047

Query: 213  QELEKSMKMQQEVVEMRKKNE----EFKKLALAGIGQPVKKSVSQVTKSVD----FHFRT 264
              L+K  K +QE+ ++++K E    +F +  +A +   + +   Q+ K  +       R 
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 265  DERIKQHPKNQEEYKEVN-FTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVST 323
            D+ I Q     ++ +E+    S+L++   S              N ++ +KR   E +  
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR---------NKAEKQKRDLGEELEA 1157

Query: 324  YVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTC 383
               L  ++ED    T  +  LR+K++       + +V K   D +T      H A+    
Sbjct: 1158 ---LKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEET----RSHEAQVQEM 1204

Query: 384  KSTAELEAEEL-EKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRI- 441
            +       EEL E+L+Q+K     LD                K   E    DL  E R+ 
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKN--------------KQTLEKENADLAGELRVL 1250

Query: 442  ----QERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRM 497
                QE E KKK  +   +     C         G   +  L   V K     L+N +  
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSD-------GERARAELNDKVHK-----LQNEVES 1298

Query: 498  PTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKE 557
             T    E +   +  A+ V    +  + Q  +    E      +   K RQL++E+   +
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVA--SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 558  LQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR 617
             Q  E  + K     H  T+N+     K   Q     +E    G  + Q     L ++  
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 618  QQKEAACFKARPNTVISQE---PFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL 674
            ++  A     +    + QE     V    ++ +   L     +    LA EK    +   
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 675  EKRMAEVEAQ----KAQQLEEARLQEEEQKKEELARLRREL 711
            E+  AE EA+    KA  L  A L+E  + KEEL R  + L
Sbjct: 1477 ERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKML 1516



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/204 (25%), Positives = 94/204 (46%), Gaps = 37/204 (18%)

Query: 545  KERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALK 604
            KE +LQK K+ ++  + E+ + +       +  NL +++++  T++     E   R A K
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 605  AQTWKHQL--------EEELRQQKEAACFKARPNTVISQEPFVPKKE--------KKSVA 648
             Q  +  L        EEE R Q+  A  K     ++  E  + ++E        +K  A
Sbjct: 924  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 649  EGLSGSLVQEPFQLATE--KRAKERQELEKRMAEV------EAQKAQQLE---------- 690
            E     L  E   +  +  K +KER+ LE+R++++      E +KA+ L           
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043

Query: 691  ---EARLQEEEQKKEELARLRREL 711
               E RL++EE+ ++EL +L+R+L
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKL 1067



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 11/119 (9%)

Query: 612  LEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKER 671
            L EE  + K     K +  ++IS+     KKE+KS          ++  +    K   + 
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----------RQELEKLKRKLEGDA 1071

Query: 672  QELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSD 730
             +  +++A+++AQ A+ L+    ++EE+ +  LARL  E+  K N ++K + LE   SD
Sbjct: 1072 SDFHEQIADLQAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 79/367 (21%), Positives = 155/367 (42%), Gaps = 39/367 (10%)

Query: 375  KHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV--KPPTEPIG 432
            K     +  +  A LE EE ++ QQ + + +++  ++L+    L ++     K   E + 
Sbjct: 924  KQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 433  FDLEIEKR------IQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKS 486
             + +I+K       + ++ +K   E +  E       T + E+     E+K   +T  K+
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKN 1037

Query: 487  PAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKE 546
               ++ + + +  K++E+  + +    + +      F  QI + +  +I         KE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKE 1096

Query: 547  RQLQKE---------------KKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIE 591
             +LQ                 KKI+EL+ G +   +          N  EK+ +++ + E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELE-GHISDLQEDLDSERAARNKAEKQKRDLGE-E 1154

Query: 592  PFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKK--SVAE 649
               L+T+    L +   + +L  + R+Q+     KA      S E  V +  +K     E
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAK-REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 650  GLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRR 709
             L+  L  E F+ A     K +Q LEK  A++ A + + L +A+ QE E KK++L    +
Sbjct: 1214 ELTEQL--EQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAK-QEVEHKKKKLEAQVQ 1269

Query: 710  ELVHKAN 716
            EL  K +
Sbjct: 1270 ELQSKCS 1276



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 78/408 (19%), Positives = 149/408 (36%), Gaps = 57/408 (13%)

Query: 309  LSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINL-LPSKSSVTKICRDP 367
            L +GKKR   E  +      ++   + K    +  L+ + DD+ + L ++  +       
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 368  QTPVLQTKHRARAVTCKSTAE---LEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV 424
            Q    Q     + ++ K   E    EAE  EK  +    AR L+  +     +      +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 425  KPPTEP-IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITV 483
            K   E  +    ++ K + E E  K+  +   E        + LED +   E   L + V
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLEELEDELQATEDAKLRLEV 1574

Query: 484  PKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSR 543
                  ALK +     +  +E++E    + Q   H                   +  +  
Sbjct: 1575 NMQ---ALKGQFERDLQARDEQNEEKRRQLQRQLH------------------EYETELE 1613

Query: 544  DKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGAL 603
            D+ +Q       K+  +G++   K L L     I   E+ +K + +++            
Sbjct: 1614 DERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQA----------- 1659

Query: 604  KAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLA 663
                   Q+++  R+ ++A   +         E F   KE +  A+ L   L+Q    LA
Sbjct: 1660 -------QMKDFQRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 664  TEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRREL 711
              +RA+++ +LEK     E   +     A   E+ + +  +A+L  EL
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 12/108 (11%)

Query: 613 EEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQ 672
           +EE  Q KE    K +     ++      ++K S       +L+QE  Q  TE  A E +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYA-EAE 914

Query: 673 ELEKRMAEVEAQKAQQLEE------ARLQEEEQKKEELARLRRELVHK 714
           E+  R+A     K Q+LEE      ARL+EEE + ++L   R+++  +
Sbjct: 915 EMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 151/701 (21%), Positives = 260/701 (37%), Gaps = 115/701 (16%)

Query: 67   QQAIVTPLKPVDNTYYKEAEKENLVEQSIPSN--------------ACSSLEVEAAI--- 109
            QQ     LK ++  + +  E++NL+++ + +               A    E+E  +   
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 110  --------SRKTPAQPQRRSLR---LSAQKDLEQKEKHHVKMKAKRCATPVII----DEI 154
                     R    Q +R+ +    L  ++ LE++E    K++ ++      I    DEI
Sbjct: 928  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987

Query: 155  L--PSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEE 212
            L    +  K+S  +K  EE  S   D     A   EKAK    +      K + + S  E
Sbjct: 988  LVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKNLTKLK----NKHESMISELE 1040

Query: 213  QELEKSMKMQQEVVEMRKKNE----EFKKLALAGIGQPVKKSVSQVTKSVD----FHFRT 264
              L+K  K +QE+ ++++K E    +F +  +A +   + +   Q+ K  +       R 
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 265  DERIKQHPKNQEEYKEVN-FTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVST 323
            D+ I Q     ++ +E+    S+L++   S              N ++ +KR   E +  
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR---------NKAEKQKRDLGEELEA 1150

Query: 324  YVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTC 383
               L  ++ED    T  +  LR+K++       + +V K   D +T      H A+    
Sbjct: 1151 ---LKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEET----RSHEAQVQEM 1197

Query: 384  KSTAELEAEEL-EKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRI- 441
            +       EEL E+L+Q+K     LD                K   E    DL  E R+ 
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKN--------------KQTLEKENADLAGELRVL 1243

Query: 442  ----QERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRM 497
                QE E KKK  +   +     C         G   +  L   V K     L+N +  
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSD-------GERARAELNDKVHK-----LQNEVES 1291

Query: 498  PTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKE 557
             T    E +   +  A+ V    +  + Q  +    E      +   K RQL++E+   +
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVA--SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 558  LQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR 617
             Q  E  + K     H  T+N+     K   Q     +E    G  + Q     L ++  
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 618  QQKEAACFKARPNTVISQE---PFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL 674
            ++  A     +    + QE     V    ++ +   L     +    LA EK    +   
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 675  EKRMAEVEAQ----KAQQLEEARLQEEEQKKEELARLRREL 711
            E+  AE EA+    KA  L  A L+E  + KEEL R  + L
Sbjct: 1470 ERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKML 1509



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/204 (25%), Positives = 94/204 (46%), Gaps = 37/204 (18%)

Query: 545  KERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALK 604
            KE +LQK K+ ++  + E+ + +       +  NL +++++  T++     E   R A K
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 605  AQTWKHQL--------EEELRQQKEAACFKARPNTVISQEPFVPKKE--------KKSVA 648
             Q  +  L        EEE R Q+  A  K     ++  E  + ++E        +K  A
Sbjct: 917  KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 649  EGLSGSLVQEPFQLATE--KRAKERQELEKRMAEV------EAQKAQQLE---------- 690
            E     L  E   +  +  K +KER+ LE+R++++      E +KA+ L           
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036

Query: 691  ---EARLQEEEQKKEELARLRREL 711
               E RL++EE+ ++EL +L+R+L
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKL 1060



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 11/119 (9%)

Query: 612  LEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKER 671
            L EE  + K     K +  ++IS+     KKE+KS          ++  +    K   + 
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----------RQELEKLKRKLEGDA 1064

Query: 672  QELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSD 730
             +  +++A+++AQ A+ L+    ++EE+ +  LARL  E+  K N ++K + LE   SD
Sbjct: 1065 SDFHEQIADLQAQIAE-LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 79/367 (21%), Positives = 155/367 (42%), Gaps = 39/367 (10%)

Query: 375  KHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV--KPPTEPIG 432
            K     +  +  A LE EE ++ QQ + + +++  ++L+    L ++     K   E + 
Sbjct: 917  KQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 433  FDLEIEKR------IQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKS 486
             + +I+K       + ++ +K   E +  E       T + E+     E+K   +T  K+
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKN 1030

Query: 487  PAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKE 546
               ++ + + +  K++E+  + +    + +      F  QI + +  +I         KE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKE 1089

Query: 547  RQLQKE---------------KKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIE 591
             +LQ                 KKI+EL+ G +   +          N  EK+ +++ + E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELE-GHISDLQEDLDSERAARNKAEKQKRDLGE-E 1147

Query: 592  PFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKK--SVAE 649
               L+T+    L +   + +L  + R+Q+     KA      S E  V +  +K     E
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAK-REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 650  GLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRR 709
             L+  L  E F+ A     K +Q LEK  A++ A + + L +A+ QE E KK++L    +
Sbjct: 1207 ELTEQL--EQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAK-QEVEHKKKKLEAQVQ 1262

Query: 710  ELVHKAN 716
            EL  K +
Sbjct: 1263 ELQSKCS 1269



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 78/408 (19%), Positives = 149/408 (36%), Gaps = 57/408 (13%)

Query: 309  LSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINL-LPSKSSVTKICRDP 367
            L +GKKR   E  +      ++   + K    +  L+ + DD+ + L ++  +       
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 368  QTPVLQTKHRARAVTCKSTAE---LEAEELEKLQQYKFKARELDPRILEGGPILPKKPPV 424
            Q    Q     + ++ K   E    EAE  EK  +    AR L+  +     +      +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 425  KPPTEP-IGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITV 483
            K   E  +    ++ K + E E  K+  +   E        + LED +   E   L + V
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQME--EMKTQLEELEDELQATEDAKLRLEV 1567

Query: 484  PKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSR 543
                  ALK +     +  +E++E    + Q   H                   +  +  
Sbjct: 1568 NMQ---ALKGQFERDLQARDEQNEEKRRQLQRQLH------------------EYETELE 1606

Query: 544  DKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGAL 603
            D+ +Q       K+  +G++   K L L     I   E+ +K + +++            
Sbjct: 1607 DERKQRALAAAAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQA----------- 1652

Query: 604  KAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLA 663
                   Q+++  R+ ++A   +         E F   KE +  A+ L   L+Q    LA
Sbjct: 1653 -------QMKDFQRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 664  TEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRREL 711
              +RA+++ +LEK     E   +     A   E+ + +  +A+L  EL
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 12/108 (11%)

Query: 613 EEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQ 672
           +EE  Q KE    K +     ++      ++K S       +L+QE  Q  TE  A E +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYA-EAE 907

Query: 673 ELEKRMAEVEAQKAQQLEE------ARLQEEEQKKEELARLRRELVHK 714
           E+  R+A     K Q+LEE      ARL+EEE + ++L   R+++  +
Sbjct: 908 EMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 132/659 (20%), Positives = 264/659 (40%), Gaps = 94/659 (14%)

Query: 88  ENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLE------QKEKHHVKMK 141
           E L EQ   S   +  E+E A+S     +  RR L+    + ++      ++E+  ++ +
Sbjct: 399 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458

Query: 142 AKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPP 201
             R    V+ D +  S + +++  +K  E+E +  +    K   + E+         +  
Sbjct: 459 LSRVKQEVV-DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEK 517

Query: 202 AKQKFLKSTEEQELEKSMKMQQEVVEMRKK----NEEFKKLALAGIGQPVKKSVSQVTKS 257
           ++ ++LK ++E+E ++S+ +++  +E++KK      E K   L    +  +  + ++  S
Sbjct: 518 SQSEYLKISQEKEQQESLALEE--LELQKKAILTESENKLRDLQQEAETYRTRILELESS 575

Query: 258 VDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSS-PARVTKGCTIVKPFNLSQGKKRT 316
           +       E+  Q  KNQ +   V+  +E  KH       V K  T ++     Q    T
Sbjct: 576 L-------EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628

Query: 317 FDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKH 376
               V     L QQ +   ++      LR K                C   +  +L+ K 
Sbjct: 629 EKLQV-----LKQQYQTEMEK------LREK----------------CEQEKETLLKDK- 660

Query: 377 RARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLE 436
               +      E+  + LEKL     K  EL+    E   +L  K   K   E      +
Sbjct: 661 --EIIFQAHIEEMNEKTLEKLD---VKQTELESLSSELSEVL--KARHKLEEELSVLKDQ 713

Query: 437 IEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIR 496
            +K  QE E+K    DE    H +   + I E  V +   +            ALK++I 
Sbjct: 714 TDKMKQELEAKM---DEQKNHHQQQVDSIIKEHEVSIQRTEK-----------ALKDQIN 759

Query: 497 MPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEAR--TVEICPF-SFDSRDKERQLQKEK 553
                 +E D+ +      V +     K    E +  + ++  F S+ S   E+    E+
Sbjct: 760 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819

Query: 554 KIKELQK-------------GEVPKFKALPLPHFDTINLPEKKVKN-VTQIEPFCLETDR 599
           ++ +LQ+              +V + +A        ++  + +V++ + Q+E    E ++
Sbjct: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ 879

Query: 600 RGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEP 659
           +     Q ++ +LE+  ++Q++          +I Q     KKE + + + LS    ++ 
Sbjct: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK--EDS 937

Query: 660 FQLATEKRAKERQELEKRMAEVEAQKAQQLEEA----RLQEEEQKKEELARLRRELVHK 714
             +  E+   + +  EK+M +V+ QKA++++E      L +E + K+EL     EL  K
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVK-QKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 120/616 (19%), Positives = 239/616 (38%), Gaps = 117/616 (18%)

Query: 131 EQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKA 190
           E K + H  ++ K      +   I           ++K + E +A ++  +  +++ +  
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427

Query: 191 KGRHTVPCMPPAKQKFLKSTEEQEL----EKSMKMQQEVVEMRKKNEEFKKLALAGIGQP 246
           + R  +      + K ++ T E+E     ++  +++QEVV++ KK+ E +   +A + + 
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ---IAKLQKL 484

Query: 247 VKKSVSQVTKSVDFHFRTDERIKQHP------KNQEEYKEVNFTSELRKHPSSPARVTKG 300
            +K +++  + +    +T ER  Q        K+Q EY +++   E ++  +      + 
Sbjct: 485 HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544

Query: 301 CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV 360
             I+     S+ K R   +   TY     ++E   +++      +SK   ++L   K+  
Sbjct: 545 KAILTE---SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601

Query: 361 TKICRDPQTPVLQTKHRARAVTCKSTAE-LEAEELEKL-QQYKFKARELDPRILEGGPIL 418
            K     +  V+  KH+    + K   + L  E+L+ L QQY+ +  +L           
Sbjct: 602 NK-----EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR---------- 646

Query: 419 PKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKV 478
                              EK  QE+E+  K ++  F+ H      K LE +  V + ++
Sbjct: 647 -------------------EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL-DVKQTEL 686

Query: 479 LPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPF 538
             ++   S     ++++         E+E  V+K                          
Sbjct: 687 ESLSSELSEVLKARHKL---------EEELSVLK-------------------------- 711

Query: 539 SFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKN-VTQIEPFCLET 597
             D  DK +Q + E K+ E +     +  ++   H  +I   EK +K+ + Q+E    E 
Sbjct: 712 --DQTDKMKQ-ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 598 DRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQ 657
           D+    + Q     LE ++++ +      +    V         ++ K+  E L+  L Q
Sbjct: 769 DKH-LKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA-QLQQ 826

Query: 658 EPFQLATEKRAKERQELEKRMAEVEAQK-----------------AQQLEEARLQEEEQK 700
           +   L TE     R  L K++AEVEAQK                  QQLE+    E EQK
Sbjct: 827 KLLDLETE-----RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN-SEMEQK 880

Query: 701 KEELARLRRELVHKAN 716
            + L ++    +   N
Sbjct: 881 VKSLTQVYESKLEDGN 896



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 115/614 (18%), Positives = 235/614 (38%), Gaps = 101/614 (16%)

Query: 203 KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHF 262
           ++K L+    Q  +KS++   E+ E  + +++ KK         +++    ++       
Sbjct: 170 EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS 229

Query: 263 RTDERIKQHPKNQEEYKEVN--------FTSELRKHPSSPARVTKGCTIVKPFNLSQGKK 314
              +R++  P N +  K +         FT E          V  G ++     L Q  K
Sbjct: 230 LLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK 289

Query: 315 RTFD------ETVSTYVP----LAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKIC 364
           R  +      ET+ ++      L  + E   ++   R     K  D+++      +T++ 
Sbjct: 290 RQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL- 348

Query: 365 RDPQTPVLQTKHRARAVTCKS------TAELEAEELEKLQ----QYKFKARELDPRILEG 414
           RD +  + Q +     V  ++      T E++ EE+ +L+    Q   +  EL  +  + 
Sbjct: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS 408

Query: 415 GPI----LPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDV 470
                  L K       TE     L+ E   Q +  +K +E+E          +++ ++V
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL--SRVKQEV 466

Query: 471 VGV----PEKKVLPITVPKSPAFALKNRI---RMPTKEDE-EEDEPVVIKAQPVPHYGVP 522
           V V     E+++  +        A K +    ++ T+E E +E   V ++     +  + 
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526

Query: 523 FKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQK-GEVPKFKALPLPHFDTINLPE 581
            + +  E+  +E      + + K    + E K+++LQ+  E  + + L L      +L E
Sbjct: 527 QEKEQQESLALE----ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582

Query: 582 KK-------------------------VKNVTQIEPFCLETDRRGALKAQTWKHQ----- 611
            K                          K+ T++E    + D     K Q  K Q     
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642

Query: 612 --LEEELRQQKEAAC------FKAR---PNTVISQEPFVPKKEKKSVAEGLSGSL----- 655
             L E+  Q+KE         F+A     N    ++  V + E +S++  LS  L     
Sbjct: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702

Query: 656 VQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLE------EARLQEEEQK-KEELARLR 708
           ++E   +  ++  K +QELE +M E +    QQ++      E  +Q  E+  K+++ +L 
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762

Query: 709 RELVHKANPIRKYQ 722
             L  +   ++++Q
Sbjct: 763 LLLKERDKHLKEHQ 776



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 37/176 (21%), Positives = 73/176 (41%), Gaps = 24/176 (13%)

Query: 83   KEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSL--RLSAQKDLEQKE-----K 135
            K  +KE+ +E  + S     +E+E  I++KT        +    + QKD+E KE     +
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ 1567

Query: 136  HHVKM------KAKRCATPVI-IDEILPSKKMKVSNNKKK----------PEEEGSAHQD 178
            H  ++      + K     ++ ++  + S K ++   KK+           EEE  A +D
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627

Query: 179  TAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEE 234
              E  +++      R     +   K++ L   EE+E +     +  + E+  K +E
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE 1683


>gi|8922940 gamma-taxilin [Homo sapiens]
          Length = 528

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 46/207 (22%), Positives = 100/207 (48%), Gaps = 14/207 (6%)

Query: 528 PEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNV 587
           PE +   +C    D  ++ R +QK+ KI + ++ ++ K K     H  + +   K +   
Sbjct: 152 PEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKV----HLQSEH--SKAILAR 205

Query: 588 TQIEPFCLETDRRG-ALKAQTWKHQLEEELRQQKEAACFKARPNTVISQ----EPFVPKK 642
           +++E  C E  R    LK +  +   EEE R+++  A F+   + + +Q    +    K 
Sbjct: 206 SKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKL 265

Query: 643 EKKSVAEGLSGSLVQEPFQLATEKRAK--ERQELEKRMAEVEAQKAQQLEEARLQEEEQK 700
            ++++  G     + E + L  E   K  +R+EL++++ + + Q+  QL +   ++ +++
Sbjct: 266 RQENIELGEKLKKLIEQYALREEHIDKVFKRKELQQQLVDAKLQQTTQLIKEADEKHQRE 325

Query: 701 KEELARLRRELVHKANPIRKYQGLEIK 727
           +E L +   E  HK   + K Q +++K
Sbjct: 326 REFLLKEATESRHKYEQM-KQQEVQLK 351


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1421

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1463

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1516

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1572

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1799

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1800 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1848

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALK 1931



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1449

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALE 1539



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2528

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2589 EENQRLREQL 2598



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1713 QELIRLRAE 1721



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2079



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2456 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2515 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1556 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1612

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1613 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1666

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1667 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1723 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1754


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1425

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1467

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1520

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1576

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1689

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1803

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1804 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1852

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1913 QKGLVEDTLRQRRQVEEEILALK 1935



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1453

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALE 1543



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2532

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2592

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2593 EENQRLREQL 2602



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1717 QELIRLRAE 1725



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2083



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2460 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2519 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2572

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2573 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1560 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1616

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1617 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1670

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1671 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1727 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1758


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1421

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1463

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1516

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1572

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1799

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1800 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1848

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALK 1931



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1449

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALE 1539



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2528

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2589 EENQRLREQL 2598



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1713 QELIRLRAE 1721



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2079



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2456 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2515 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1556 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1612

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1613 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1666

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1667 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1723 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1754


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1389

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1431

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1484

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1540

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1653

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1767

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1768 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1816

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1877 QKGLVEDTLRQRRQVEEEILALK 1899



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1417

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALE 1507



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2496

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2556

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2557 EENQRLREQL 2566



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1681 QELIRLRAE 1689



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2047



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2424 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2483 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2536

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2537 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1524 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1580

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1581 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1634

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1635 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1691 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1722


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1558

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1600

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1653

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1709

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1822

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1936

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1937 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1985

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 2046 QKGLVEDTLRQRRQVEEEILALK 2068



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1586

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALE 1676



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2665

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2725

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2726 EENQRLREQL 2735



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1850 QELIRLRAE 1858



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2216



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2593 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2652 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2705

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2706 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1693 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1749

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1750 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1803

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1804 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1860 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1891


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1399

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1441

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1494

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1550

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1663

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1777

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1778 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1826

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1887 QKGLVEDTLRQRRQVEEEILALK 1909



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1427

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALE 1517



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2506

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2566

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2567 EENQRLREQL 2576



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1631 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1691 QELIRLRAE 1699



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2057



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2434 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2493 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2546

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2547 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2598



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1534 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1590

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1591 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1644

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1645 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1701 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1732


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1407

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1449

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1502

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1558

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1671

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1785

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1786 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1834

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1895 QKGLVEDTLRQRRQVEEEILALK 1917



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1435

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALE 1525



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2514

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2574

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2575 EENQRLREQL 2584



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1639 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1698

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1699 QELIRLRAE 1707



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2065



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2442 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2501 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2554

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2555 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2606



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1542 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1598

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1599 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1652

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1653 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1709 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1740


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 117/683 (17%), Positives = 256/683 (37%), Gaps = 79/683 (11%)

Query: 48   KNGTGGLFQGKTPLRKANLQQAIVTP--LKPVDNTYYKEAEKENLVEQSIPSNACSSLEV 105
            ++G+  + Q    LR    +   +T   +K +  T  +  E+E L EQ          EV
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392

Query: 106  EAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNN 165
            EAA+ ++          +  A+++ ++ ++   +   +R    V   +    +K  +   
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ----QKRSIQEE 1448

Query: 166  KKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEV 225
             ++  +   A      + A + E+++ R                  E+E+ + +++Q E 
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRLR-----------------IEEEI-RVVRLQLEA 1490

Query: 226  VEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYK---EVN 282
             E ++   E +  AL    +  +    Q  +         ER+++  +++ + K   EV 
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEA-------ERLRRQVQDESQRKRQAEVE 1543

Query: 283  FTSELRKHPSSPARVTKGCTIVKPFNL--SQGKKRTFDETVSTYVPLAQQVEDFHKRTPN 340
              S ++    +     +    ++   L   + ++R     V      A+QV+   +    
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER----ARQVQVALETAQR 1599

Query: 341  RYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRA-RAVTCKSTAELEAEELEK-LQ 398
                  +    +     + + +  ++    V Q +  A R    ++ AE   EE E+ L+
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 399  QYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFH 458
            +++ KA E     L+   +  +K   +        + E +K   ERE++++ + E     
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVR 1712

Query: 459  SRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKED---EEEDEPVVIKAQP 515
             R    + LE    + E         +     L+       ++    EEE   +  +A  
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772

Query: 516  VPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFD 575
                    + ++ + R       +  +R +E      +K K+  + E  +F+ L      
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL------ 1826

Query: 576  TINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR--QQKEAACFKARPNTVI 633
                     +   ++     E  R+  L  +    Q  E  R   +K AA  +A   T +
Sbjct: 1827 --------AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRL 1875

Query: 634  SQEPFVPKKEKKSVAEGLSGSLVQEPFQ--LATEKRAKERQELEKRMAEV------EAQK 685
              E  +  KEK++  E L      E FQ     E+ A+ + ++E+R+A++      E ++
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935

Query: 686  AQQLEEARLQEEEQKKEELARLR 708
             + L E  L++  Q +EE+  L+
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALK 1958



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 43/210 (20%)

Query: 547  RQLQKEKKIKELQKGE-----------VPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
            R++++E+++ E Q+ E           + K + L   H       E++ K + Q     +
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428

Query: 596  ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
                  A+ AQ  K  ++EEL+Q ++            S E  +  K +++ A   S   
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQ------------SSEAEIQAKARQAEAAERSRLR 1476

Query: 656  VQEPFQL------ATEKRAK----ERQELEKRMAEVEAQKAQQLEEA-----RLQEEEQK 700
            ++E  ++      ATE++      E Q L  R  E EAQK Q  EEA     ++Q+E Q+
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 701  K-----EELARLRRELVHKANPIRKYQGLE 725
            K     E  +R++ E        R  Q LE
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALE 1566



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 35/130 (26%), Positives = 65/130 (50%), Gaps = 23/130 (17%)

Query: 603  LKAQTWKHQLEEELRQQKEAA--CFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF 660
            LK++  +   +E+L Q+ +A    F +  ++++ +E F+  +++K+  E L    V +  
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--EQEKAKLEQLFQDEVAKAQ 2555

Query: 661  QLATEKRAKERQ-------------ELEKRMAEVEA------QKAQQLEEARLQEEEQKK 701
            QL  E++ +++Q             E  +R  E E       ++ QQLE+ R Q+EE   
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2615

Query: 702  EELARLRREL 711
            EE  RLR +L
Sbjct: 2616 EENQRLREQL 2625



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR-MAEVEAQKAQQLEEARLQEEEQKK 701
            ++KS+A+  +    +E  + A  +   E Q + +R +AE E +K +QL E   Q+    +
Sbjct: 1680 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1739

Query: 702  EELARLRRE 710
            +EL RLR E
Sbjct: 1740 QELIRLRAE 1748



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 37/114 (32%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 595  LETDRRGALKAQTWKHQLEEELRQQKE-AACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
            LE  R+  L A+  + + E E R QK  AA  +A      + E     K K   A  L  
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053

Query: 654  SLVQEP---FQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEEL 704
               QE     QLA E   K  Q  EK  A    QK Q+L++  LQ+E+   ++L
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQL 2106



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/172 (20%), Positives = 76/172 (44%), Gaps = 8/172 (4%)

Query: 84   EAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKD-LEQKEKHHVKMKA 142
            E EKE L +Q        S E++     +   + Q       ++KD L Q+E+   + KA
Sbjct: 2483 EREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541

Query: 143  KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
            K     +  DE+  +++++    +++ + E    Q+     AS  E  + +H        
Sbjct: 2542 K--LEQLFQDEVAKAQQLREEQQRQQQQME----QERQRLVASMEEARRRQHEAEEGVRR 2595

Query: 203  KQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQV 254
            KQ+ L+  E+Q  ++   + +E   +R++ +  ++   A +    + + SQV
Sbjct: 2596 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2647



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 611  QLEEELRQQKEAACFKARPNTVISQEPFVPK--KEKKSVAEGLSGSL--VQEPFQLATEK 666
            QL +E  Q++  A  KA    V  +E  + +  ++++SV + L G     +   + A E 
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123

Query: 667  RAK-ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
            R + ER+  + R    EA++ +Q  E + Q   Q +    +LR+E   +A
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 31/215 (14%)

Query: 526  QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINL---PEK 582
            ++  AR V++       R  E +LQ ++     +  ++ +  +L   H     L    E+
Sbjct: 1583 EVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLER--SLQEEHVAVAQLREEAER 1639

Query: 583  KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
            + +   + E    E +R    + + W+ +  E LR + +A   +      ++Q     +K
Sbjct: 1640 RAQQQAEAERAREEAER----ELERWQLKANEALRLRLQAE--EVAQQKSLAQAEAEKQK 1693

Query: 643  EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKR--MAEVEAQK--AQQLEEARLQEEE 698
            E+        G   ++    A  +R    QELEK+  +AE  AQ+  A + E  RL+ E 
Sbjct: 1694 EEAEREARRRGKAEEQ----AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749

Query: 699  QK--------KEELARLRRELVHKANPIRKYQGLE 725
            ++        +EELARL+RE    A   +K Q LE
Sbjct: 1750 EQGEQQRQLLEEELARLQRE---AAAATQKRQELE 1781


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 122/582 (20%), Positives = 234/582 (40%), Gaps = 100/582 (17%)

Query: 156 PSKKM--KVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQ 213
           P +K+  KV++ +K+  +E    ++  EK A+  EK + +        AK++    T E+
Sbjct: 154 PERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEK 213

Query: 214 ELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPK 273
             EK+ K      E++   +E  K   A + + V+K+ S+  +  D   +    + +H +
Sbjct: 214 SEEKTKK------EVKGGKQEKVKQTAAKV-KEVQKTPSKPKEKED---KEKAAVSKH-E 262

Query: 274 NQEEYKEVNFTSELRKH------------PSSPARVTKGCTIVKP-FNLSQGKKRTFDET 320
            +++Y    +  ++  H            P  P       T   P     +G+K+  ++ 
Sbjct: 263 QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKK 322

Query: 321 VSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARA 380
           V++     ++ ED  K++     +  +K +    P K+S TK     Q  V   K  A+A
Sbjct: 323 VTSETK-KKEKEDIKKKSEKETAIDVEKKE----PGKASETK-----QGTV---KIAAQA 369

Query: 381 VTCKSTAELEAEELEK---LQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEI 437
              K   + ++++ +K   ++Q K K +E   + +E     P K P K  + P       
Sbjct: 370 AAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVE-----PAKSPKKEHSVP------- 417

Query: 438 EKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRM 497
                +++ K KTE             +  E++  V  KK +P    +     ++  IR 
Sbjct: 418 ----SDKQVKAKTE-------------RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK 460

Query: 498 ----PTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVE-ICPFSFDSRDKERQLQKE 552
                T    ++ EP+  K + VP      K + PE +  E +     + + K  QLQ +
Sbjct: 461 EKSGKTSSILKDKEPIKGKEEKVP---ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK 517

Query: 553 KKIK---ELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWK 609
           K+ K   +++K   P        H   I  PEK V +    E    +      +KA T +
Sbjct: 518 KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ------VKAVTIE 571

Query: 610 HQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAK 669
              +   +  K+A   +  P ++ + +P    K    V E  SG    E     +EK +K
Sbjct: 572 KTAKP--KPTKKAEHREREPPSIKTDKPKPTPKGTSEVTE--SGKKKTE----ISEKESK 623

Query: 670 ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRREL 711
           E+ +    M  +  +K    +E+       K E+ AR+ +++
Sbjct: 624 EKAD----MKHLREEKVSTRKESLQLHNVTKAEKPARVSKDV 661



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 89/407 (21%), Positives = 156/407 (38%), Gaps = 77/407 (18%)

Query: 110 SRKTPAQP-------QRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKV 162
           SR TPA P       +++        + ++KEK  +K K+++  T + +++  P K  + 
Sbjct: 300 SRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEK-ETAIDVEKKEPGKASET 358

Query: 163 SNNKKKPEEEGSAHQDTAEKNASSPEKA-------------KGRHTVPCMPPAKQKFLKS 209
                K   + +A +D  ++++   +K              K +H  P   P K+  + S
Sbjct: 359 KQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS 418

Query: 210 TEEQELEKSMKMQQEVVEMR-------KKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHF 262
            ++Q   K+ + ++E+  +        KK E+  K     + Q ++K  S  T S+    
Sbjct: 419 -DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKT----VEQEIRKEKSGKTSSI---L 470

Query: 263 RTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLS-QGKKRTFDETV 321
           +  E IK      +E K      E         +++K    VKP     QGKK    E  
Sbjct: 471 KDKEPIK-----GKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE-- 523

Query: 322 STYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAV 381
                   Q++   K   +      K+D +     K   T     P+  VL+   + +AV
Sbjct: 524 -------PQIKKEAKPAISEKVQIHKQDIV-----KPEKTVSHGKPEEKVLK---QVKAV 568

Query: 382 TCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEI-EKR 440
           T + TA+ +  +       K + RE +P  ++     P        TE      EI EK 
Sbjct: 569 TIEKTAKPKPTK-------KAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKE 621

Query: 441 IQE-------RESKKKTEDEHFEFHS---RPCPTKILEDVVGVPEKK 477
            +E       RE K  T  E  + H+      P ++ +DV  VP  K
Sbjct: 622 SKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668


>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
          Length = 558

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 86/396 (21%), Positives = 148/396 (37%), Gaps = 65/396 (16%)

Query: 336 KRTPNRYHLRSKKDDINL--------LPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTA 387
           +R   +  LR K+++ +L        + +++SV        T   Q +    A   +  A
Sbjct: 36  RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 95

Query: 388 ELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESK 447
             E    ++LQ+   + +E DP I +    LP +       E             E+E K
Sbjct: 96  RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE---------NETTEKEEK 146

Query: 448 KKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDE 507
            ++  E +E       TK  +                     A +N+     KE+EEE++
Sbjct: 147 SESRQERYEIEETETVTKSYQK---------------NDWRDAEENKKEDKEKEEEEEEK 191

Query: 508 PVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFK 567
           P               K Q    +  E  P       K+ +++K+K+ KE  K  + + K
Sbjct: 192 PKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 251

Query: 568 ALPLPHFDTINLPEKKVKNV--TQIEP---FCLET-DRRGALKAQTWKHQLEEELRQQKE 621
                          K+K+   T   P     ++T +  GA + +  K +LEE  R++ E
Sbjct: 252 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGE 310

Query: 622 AACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEV 681
                         E F   K+K            Q+   L  E+  K+R+E  K + E 
Sbjct: 311 T-----------ESEEFEKLKQK------------QQEAALELEELKKKREERRKVLEEE 347

Query: 682 EAQKAQQLEEARLQEEEQK---KEELARLRRELVHK 714
           E ++ Q+  + +L+EEE+K   KEE+ R R E   K
Sbjct: 348 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 383


>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
          Length = 564

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 86/396 (21%), Positives = 148/396 (37%), Gaps = 65/396 (16%)

Query: 336 KRTPNRYHLRSKKDDINL--------LPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTA 387
           +R   +  LR K+++ +L        + +++SV        T   Q +    A   +  A
Sbjct: 42  RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101

Query: 388 ELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESK 447
             E    ++LQ+   + +E DP I +    LP +       E             E+E K
Sbjct: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE---------NETTEKEEK 152

Query: 448 KKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDE 507
            ++  E +E       TK  +                     A +N+     KE+EEE++
Sbjct: 153 SESRQERYEIEETETVTKSYQK---------------NDWRDAEENKKEDKEKEEEEEEK 197

Query: 508 PVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFK 567
           P               K Q    +  E  P       K+ +++K+K+ KE  K  + + K
Sbjct: 198 PKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 257

Query: 568 ALPLPHFDTINLPEKKVKNV--TQIEP---FCLET-DRRGALKAQTWKHQLEEELRQQKE 621
                          K+K+   T   P     ++T +  GA + +  K +LEE  R++ E
Sbjct: 258 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGE 316

Query: 622 AACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEV 681
                         E F   K+K            Q+   L  E+  K+R+E  K + E 
Sbjct: 317 T-----------ESEEFEKLKQK------------QQEAALELEELKKKREERRKVLEEE 353

Query: 682 EAQKAQQLEEARLQEEEQK---KEELARLRRELVHK 714
           E ++ Q+  + +L+EEE+K   KEE+ R R E   K
Sbjct: 354 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 389


>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
          Length = 1068

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 66/289 (22%), Positives = 120/289 (41%), Gaps = 30/289 (10%)

Query: 454 HFEFHS------RPCPTKILEDVVGVPEKKVLPITVPKSPAFA--LKNRIRMPTKEDEEE 505
           H +FHS      R       + ++ +P     P    ++ A A  +K  + +P +  E+E
Sbjct: 254 HEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDE 313

Query: 506 DEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPK 565
           +   +I+    P  G P        +T    P      D++ Q++  K+  E+ + E+ K
Sbjct: 314 EPENLIEISTGPPAGEPVVVADLFDQTFGP-PNGSVKDDRDLQIESLKREVEMLRSELEK 372

Query: 566 FKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACF 625
            K     +   +    K   N  + E   LE  R+   KA     QL  EL Q + A   
Sbjct: 373 IKLEAQRYIAQL----KSQVNALEGE---LEEQRKQKQKALVDNEQLRHELAQLRAAQLE 425

Query: 626 ---------KARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEK 676
                    +A      ++  +   KEK S    +   L+++     T K+    Q+ ++
Sbjct: 426 GERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRK--NADTAKQLTVTQQSQE 483

Query: 677 RMAEVEAQKAQQLEEARLQEE---EQKKEELARLRRELVHKANPIRKYQ 722
            +A V+ Q A Q+E+ + + E   E+K ++L +L+REL  KA  + + Q
Sbjct: 484 EVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQ 532


>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
          Length = 1048

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 66/289 (22%), Positives = 120/289 (41%), Gaps = 30/289 (10%)

Query: 454 HFEFHS------RPCPTKILEDVVGVPEKKVLPITVPKSPAFA--LKNRIRMPTKEDEEE 505
           H +FHS      R       + ++ +P     P    ++ A A  +K  + +P +  E+E
Sbjct: 234 HEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDE 293

Query: 506 DEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPK 565
           +   +I+    P  G P        +T    P      D++ Q++  K+  E+ + E+ K
Sbjct: 294 EPENLIEISTGPPAGEPVVVADLFDQTFGP-PNGSVKDDRDLQIESLKREVEMLRSELEK 352

Query: 566 FKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACF 625
            K     +   +    K   N  + E   LE  R+   KA     QL  EL Q + A   
Sbjct: 353 IKLEAQRYIAQL----KSQVNALEGE---LEEQRKQKQKALVDNEQLRHELAQLRAAQLE 405

Query: 626 ---------KARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEK 676
                    +A      ++  +   KEK S    +   L+++     T K+    Q+ ++
Sbjct: 406 GERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRK--NADTAKQLTVTQQSQE 463

Query: 677 RMAEVEAQKAQQLEEARLQEE---EQKKEELARLRRELVHKANPIRKYQ 722
            +A V+ Q A Q+E+ + + E   E+K ++L +L+REL  KA  + + Q
Sbjct: 464 EVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQ 512


>gi|118918413 MICAL C-terminal like [Homo sapiens]
          Length = 695

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 95/425 (22%), Positives = 156/425 (36%), Gaps = 61/425 (14%)

Query: 291 PSSPARVTKGC---TIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSK 347
           P SP R+       ++    + S+G K+ + +  S  +P       F  R  N     S 
Sbjct: 266 PKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQESKTLPAQACTRSFSLRKTN-----SN 320

Query: 348 KDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKAREL 407
           KD     P ++  +     P  P L+T H       K    L +    K++         
Sbjct: 321 KDGDQHSPGRNQSSAF--SPPDPALRT-HSLPNRPSKVFPALRSPPCSKIEDV------- 370

Query: 408 DPRILEGGPILPKKPPV-KPPTEPIGFDLEIEKRIQERESKKKTEDEHFE-FHSRPCPTK 465
            P +LE   +    P   KPP + I              S  + +D+ FE F       K
Sbjct: 371 -PTLLEKVSLQENFPDASKPPKKRISLF-----------SSLRLKDKSFESFLQESRQRK 418

Query: 466 ILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKP 525
            + D+ G P++KVL    P+  A AL+ ++  P K         + +A P P    P  P
Sbjct: 419 DIRDLFGSPKRKVL----PEDSAQALE-KLLQPFKSTS------LRQAAPPPPPPPPPPP 467

Query: 526 QIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVK 585
             P A   +   F   ++  E               E     +L L    T+   +K  K
Sbjct: 468 PPPTAGGADSKNFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKLEK 527

Query: 586 NVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKK 645
            + Q+     + + +   KAQ  + QLEE   +Q+ +     R    +  E     +++ 
Sbjct: 528 AMKQL---VKQEELKRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDE- 583

Query: 646 SVAEGLSGSLVQEPFQLATEKRAKERQE-------LEKRMAEVEAQKAQQLEEARLQEEE 698
                    L+QE F+L  EK    R E        E  + + +++  Q+L E  L+EE 
Sbjct: 584 -------AQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLREKMLKEES 636

Query: 699 QKKEE 703
           QK E+
Sbjct: 637 QKDEK 641


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 46/173 (26%), Positives = 79/173 (45%), Gaps = 27/173 (15%)

Query: 543 RDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGA 602
           + K  +LQ++ ++ E +K E              I L  K++K   +   F L   +   
Sbjct: 186 KKKNAELQEKLRLAESEKSE--------------IQLNVKELKRKLERAKFLLPQVQTNT 231

Query: 603 LKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQL 662
           L+ + W+   EEELR+Q++    K R      +E    ++E+    EG      QE    
Sbjct: 232 LQEEMWRQ--EEELREQEK----KIRKQ----EEKMWRQEERLREQEGKMRE--QEEKMR 279

Query: 663 ATEKRAKERQ-ELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHK 714
             EKR +E++ EL ++  E+  QK  + +E ++QE+E+K  E     RE   K
Sbjct: 280 RQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 117/632 (18%), Positives = 250/632 (39%), Gaps = 82/632 (12%)

Query: 86  EKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRC 145
           EK  L E        +  E++  + R     PQ ++  L  +   +++E    + K ++ 
Sbjct: 194 EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 253

Query: 146 ATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQK 205
              +   E    ++++    K + +EE    Q   EK     EK             +QK
Sbjct: 254 EEKMWRQE----ERLREQEGKMREQEEKMRRQ---EKRLREQEKELREQEKELR---EQK 303

Query: 206 FLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTD 265
            L+  EEQ  E+  KM ++  +MR++ E+  +     + +  K+   Q  K  D   R  
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE-ERLWEQEKQMREQEQKMRDQEERMW 362

Query: 266 ERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYV 325
           E+ ++  + +E  +E     E  +      R+ +           + K R  +ET     
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIRE----------REKKMREEEET----- 407

Query: 326 PLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKS 385
            + +Q E   K+  N +    K+     LP +    K+    +    + K   +    + 
Sbjct: 408 -MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE--KLWEQEKMQEQEEKIWEQEEKIRD 464

Query: 386 TAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERE 445
             E+  +E +  +Q K + +E D    +   +  ++  +    E +    E ++R++E+E
Sbjct: 465 QEEMWGQEKKMWRQEKMREQE-DQMWEQEEKMRDQEQKMWDQEERM---WEQDERLREKE 520

Query: 446 SKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEE 505
            + + + + ++   +    K  ++     EKK    T  +      + R+R   K+  EE
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQE----QEKK----TWDQEEKMREEERMREREKKMREE 572

Query: 506 DEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPK 565
           +E +  + + +       + Q  E +  E        ++++ Q Q+EK  ++ +K     
Sbjct: 573 EEMMREQEEKMQEQEEKMREQ--EEKMWE--------QEEKMQEQEEKMWEQEEK----- 617

Query: 566 FKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACF 625
                      +   E++ K   Q E    + ++    + + W+   EE++R+Q+E    
Sbjct: 618 -----------MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ--EEKMREQEEK--M 662

Query: 626 KARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQK 685
           + +   +  QE  + ++E+K          +Q   +   E+  K R + EK   + E   
Sbjct: 663 REQEEKMQGQEEKMREQEEK----------MQGQEEKMREQEEKMRGQEEKMWGQEEKMW 712

Query: 686 AQQLEEARLQEEEQKKEELARLRRELVHKANP 717
            Q+ E+   QEE ++KEE  R ++E + +  P
Sbjct: 713 GQE-EKMWGQEEMREKEERIRDQKEKMQERLP 743



 Score = 36.6 bits (83), Expect = 0.087
 Identities = 111/591 (18%), Positives = 242/591 (40%), Gaps = 98/591 (16%)

Query: 222 QQEVVEMRKKNEEFKKLALAGIGQPV----KKSVS-----QVTKSVDFHFRTDERIKQHP 272
           Q ++ E +KK  ++++  +AG+G       KK ++     + T S   H   DE+   H 
Sbjct: 19  QNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDEKKASHQ 78

Query: 273 KNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDE-TVSTYVPLAQQ- 330
             +   +E+    E + H        K   +      SQ   R F++  +     LA + 
Sbjct: 79  HQEALRREI----EAQDHTIRILTCQK-TELETALYYSQDAARKFEDGNLGESKDLAGRL 133

Query: 331 ----------------VEDFHKRTPNRY--HLRSKKDDINLLPSKSSVTKICRDPQTPVL 372
                           V  +HK+  +RY   L  ++D ++L   ++++T      +   L
Sbjct: 134 HHSWHFAGELQRALSAVSTWHKKA-DRYIEELTKERDALSLELYRNTITNEELKKKNAEL 192

Query: 373 QTKHRARAVTCKSTAELEAEELE-KLQQYKFKARELDPRILEGG------PILPKKPPVK 425
           Q K R  A + KS  +L  +EL+ KL++ KF   ++    L+         +  ++  ++
Sbjct: 193 QEKLRL-AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR 251

Query: 426 PPTEPIGFDLEIEKRIQERESKKKTEDEHF---EFHSRPCPTKILEDVVGVPEKKVLPIT 482
              E +      E+R++E+E K + ++E     E   R    ++ E    + E+K L   
Sbjct: 252 KQEEKMWRQ---EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLR-- 306

Query: 483 VPKSPAFALKNRIRMPTKEDE--EEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF 540
             +      +   +M  +E++  E++E +  + + +       + Q  + R  E   +  
Sbjct: 307 --EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364

Query: 541 DSR---------------DKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVK 585
           D R               ++E ++Q+E++I+E +K    K +       +     +K+ +
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREK----KMREEEETMREQEEKMQKQEE 420

Query: 586 NVTQIEPFCLETDRRGALKAQTWKHQL-----------EEELRQQKEAACFKA---RPNT 631
           N+ + E    +  R    K + W+ +            EE++R Q+E    +    R   
Sbjct: 421 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480

Query: 632 VISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEE 691
           +  QE  + ++E+K + +       QE      ++R +E++E  +   ++  Q+ +  EE
Sbjct: 481 MREQEDQMWEQEEK-MRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539

Query: 692 ARLQEEEQK---------KEELARLRRELVHKANPIRKYQGLEIKSSDQPL 733
            + QE+E+K         +EE  R R + + +   + + Q  +++  ++ +
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 72/287 (25%), Positives = 130/287 (45%), Gaps = 52/287 (18%)

Query: 436 EIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRI 495
           E+EK+ QE E +K+TE+E           +I +D++   EK+ +   + K          
Sbjct: 108 EMEKQRQE-EQRKRTEEER--------KRRIEQDML---EKRKIQRELAKRAEQIEDINN 155

Query: 496 RMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQ------L 549
                  EE D+ ++I   PV  Y    K +            +F+  +KER+       
Sbjct: 156 TGTESASEEGDDSLLITVVPVKSYKTSGKMKK-----------NFEDLEKEREEKERIKY 204

Query: 550 QKEKKIK-ELQKGEVPKFKALPLPHFDTINLPEKKVK-NVTQIEPFCLETDRRGALKAQT 607
           +++K+I+ E Q+  + + K L L   D I    KK   +  +++    E +R+   + + 
Sbjct: 205 EEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQ---RQEN 261

Query: 608 WKHQLEEELRQ--QKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATE 665
            K Q EEE R+  ++E   F+     +++++     +E +  A+   G    +  +L+ E
Sbjct: 262 RKKQAEEEARKRLEEEKRAFEEARRQMVNED-----EENQDTAKIFKGYRPGK-LKLSFE 315

Query: 666 KRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELV 712
           +  ++R+E EKR AE         EEAR + EE+KK   A  RR +V
Sbjct: 316 EMERQRREDEKRKAE---------EEARRRIEEEKK-AFAEARRNMV 352



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 46/206 (22%), Positives = 93/206 (45%), Gaps = 27/206 (13%)

Query: 529 EARTVEICP----FSFDSRDKERQLQKEKKIKELQKGEVPKFKAL------PLPHFDTIN 578
           EA+   + P     +F+  +++RQ  ++K+ +E  +  + + K         + + D  N
Sbjct: 236 EAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEEN 295

Query: 579 LPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELR---QQKEAACFKARPNTVISQ 635
               K+    +     L  +     + +  K + EEE R   ++++ A  +AR N V+  
Sbjct: 296 QDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDD 355

Query: 636 EPFVPKKEKKSVAEGLSGSLVQEPFQ-LATEKRAKERQELE---KRMAEVEAQKAQQLEE 691
           +   P+  K    E L+   ++  F+ L  +K  +E++  E   K   E+E Q+ +QL +
Sbjct: 356 DS--PEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQ 413

Query: 692 ARLQEEEQKK--------EELARLRR 709
              +EEE+ +        EEL +L+R
Sbjct: 414 EMGEEEEENETFGLSREYEELIKLKR 439



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 36/134 (26%), Positives = 65/134 (48%), Gaps = 27/134 (20%)

Query: 582 KKVKNVTQIEPFCLETDRRGALKAQTWKH-QLEEELRQQKEAACFKARPNTVISQEPFVP 640
           K  KN   +E    E + +  +K +  K  + EE+    KEA C      +++  +    
Sbjct: 184 KMKKNFEDLEK---EREEKERIKYEEDKRIRYEEQRPSLKEAKCL-----SLVMDDEIES 235

Query: 641 KKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQK 700
           + +K+S++ G          +L  E+  ++RQE  K+ AE EA+K       RL+EE++ 
Sbjct: 236 EAKKESLSPG--------KLKLTFEELERQRQENRKKQAEEEARK-------RLEEEKRA 280

Query: 701 KEELARLRRELVHK 714
            EE    RR++V++
Sbjct: 281 FEE---ARRQMVNE 291



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 78/345 (22%), Positives = 131/345 (37%), Gaps = 56/345 (16%)

Query: 165 NKKKPEEEGSAHQDTAEKNASSPEKA---------KGRHTVPCMPPAKQKFLKSTEEQEL 215
           N++K E +     D  E  +S  EKA         KGR         KQ+  +  +  E 
Sbjct: 68  NRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFA----EMEKQRQEEQRKRTEE 123

Query: 216 EKSMKMQQEVVEMRKKNEEFKKLA--LAGIGQPVKKSVSQ-------VTKSVDFHFRTDE 266
           E+  +++Q+++E RK   E  K A  +  I     +S S+       +T      ++T  
Sbjct: 124 ERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG 183

Query: 267 RIKQH----PKNQEEYKEVNFTSE--LRKHPSSPARVTKGCTIV----------KPFNLS 310
           ++K++     K +EE + + +  +  +R     P+     C  +          K  +LS
Sbjct: 184 KMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLS 243

Query: 311 QGK-KRTFDETVSTYVP--LAQQVEDFHKRTPN--RYHLRSKKDDINLLPSKSSVTKICR 365
            GK K TF+E           Q  E+  KR     R    +++  +N         KI +
Sbjct: 244 PGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFK 303

Query: 366 DPQTPVLQTK----HRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK- 420
             +   L+       R R    K  AE EA    + ++  F     +  + +  P + K 
Sbjct: 304 GYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKT 363

Query: 421 --KPPVKPPTEPIGFD------LEIEKRIQERESKKKTEDEHFEF 457
             +  + P    I F+      +E EKR  E E K K E E  EF
Sbjct: 364 ISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEF 408


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/288 (20%), Positives = 123/288 (42%), Gaps = 30/288 (10%)

Query: 83  KEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKA 142
           ++A++E L E+     A +    E    RK   + + R LR   Q+  E++ +H   ++ 
Sbjct: 611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQ--EEEARRLRWLQQE--EEERRHQELLQK 666

Query: 143 KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
           K+      + +   +K++     +++ E+E    +   ++      + + R         
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726

Query: 203 KQKFLKSTEE-QELEKSMKMQQE----VVEMRKKNEEFKKLA--------------LAGI 243
           +Q+ L++  E QE EK++++Q+E     +E +KK EE ++LA               AG 
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGA 786

Query: 244 GQPVKKSVSQVTKSVDFHFRTDERIKQHPK-NQEEY-KEVNF--TSELRKHPSSPARV-T 298
            + +  +V   + +   +  T +  +  PK N + Y  ++N   +++   HP  P     
Sbjct: 787 SKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWA 846

Query: 299 KGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRS 346
           +G  + +             E   T +PL   +ED  K++  RYH R+
Sbjct: 847 RGTPLSQAIIHQYYHPPNLLELFGTILPL--DLEDIFKKSKPRYHKRT 892



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 57/257 (22%), Positives = 98/257 (38%), Gaps = 19/257 (7%)

Query: 463 PTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVP 522
           PT     V+    K+  P+ +    +F  K R R+     +EE E   ++ Q V      
Sbjct: 508 PTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQ--LRRQKVEEDKRR 565

Query: 523 FKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEK 582
              ++   R   +      +R++  Q+++EKK +  QK      K              K
Sbjct: 566 RLEEVKLKREERLRKV-LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK 624

Query: 583 KVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKK 642
           K     ++E       +    +   W  Q EEE R Q+     K        QE      
Sbjct: 625 KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-----EQERLRKAA 679

Query: 643 EKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKE 702
           E K +AE           Q   E+R +ER+E E+R  E   Q+ ++ E    ++E ++++
Sbjct: 680 EAKRLAE-----------QREQERREQERREQERREQERREQERREQERQLAEQERRREQ 728

Query: 703 ELARLRRELVHKANPIR 719
           E  +  REL  +   +R
Sbjct: 729 ERLQAERELQEREKALR 745



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 42/172 (24%), Positives = 83/172 (48%), Gaps = 11/172 (6%)

Query: 540 FDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDR 599
           F   D++ +  KE+++ E +  +  K  A  +   +     E++ + +  ++    E +R
Sbjct: 603 FAQIDEKTEKAKEERLAEEKAKK--KAAAKKMEEVEARRKQEEEARRLRWLQQE--EEER 658

Query: 600 RGALKAQTWKHQLEEELRQQKEAACF-KARPNTVISQEPFVPKKEKKSVAEGLSGSLVQE 658
           R     Q  K + +E LR+  EA    + R      QE    +++++   E       ++
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER---REQERREQERREQERREQ 715

Query: 659 PFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQ---EEEQKKEELARL 707
             QLA ++R +E++ L+      E +KA +L++ +LQ   EE++KKEE  RL
Sbjct: 716 ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 39/196 (19%), Positives = 87/196 (44%), Gaps = 22/196 (11%)

Query: 536 CPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCL 595
           C F    R +   L+++++ ++L++ +V + K           L E K+K   ++     
Sbjct: 532 CSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRR--------RLEEVKLKREERL----- 578

Query: 596 ETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSL 655
               R  L+A+    Q++EE ++Q E    +    T  ++E  + +++ K  A       
Sbjct: 579 ----RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 634

Query: 656 VQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKA 715
           V+     A  K+ +E + L     E E ++ Q+L + + +EE+++  + A  +R    + 
Sbjct: 635 VE-----ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689

Query: 716 NPIRKYQGLEIKSSDQ 731
              R+ +  E +  +Q
Sbjct: 690 QERREQERREQERREQ 705



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 42/196 (21%), Positives = 78/196 (39%), Gaps = 28/196 (14%)

Query: 59  TPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEV-----EAAISRKT 113
           TPLR       +    + ++N   KE E E L  Q +  +    LE      E  + +  
Sbjct: 524 TPLRMDPKCSFVEKERQRLENLRRKE-EAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL 582

Query: 114 PAQPQRRSLRLSAQKDLEQK------------EKHHVKMKAKRCATPVIIDEILPSKKMK 161
            A+ +   ++   +K +EQK            E+   + KAK+ A    ++E+   +K +
Sbjct: 583 QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642

Query: 162 VSNNKKK---PEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKS 218
               + +    EEE   HQ+  +K     ++   +        A+ K L    EQE  + 
Sbjct: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK-------AAEAKRLAEQREQERREQ 695

Query: 219 MKMQQEVVEMRKKNEE 234
            + +QE  E  ++ +E
Sbjct: 696 ERREQERREQERREQE 711



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 10/112 (8%)

Query: 600 RGALKAQTWKHQLEEELRQQK----EAACFKARPNTVISQEPFVPKKEKKSVAEGLSGS- 654
           R A +A+    Q E+E R+Q+    E    + R      QE  + ++E++   E L    
Sbjct: 676 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735

Query: 655 -LVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELA 705
            L +    L  +K   +R+  EK+  E +    Q+L E +LQEE++KK + A
Sbjct: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQ----QRLAERQLQEEQEKKAKEA 783


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/288 (20%), Positives = 123/288 (42%), Gaps = 30/288 (10%)

Query: 83  KEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKA 142
           ++A++E L E+     A +    E    RK   + + R LR   Q+  E++ +H   ++ 
Sbjct: 607 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQ--EEEARRLRWLQQE--EEERRHQELLQK 662

Query: 143 KRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPA 202
           K+      + +   +K++     +++ E+E    +   ++      + + R         
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722

Query: 203 KQKFLKSTEE-QELEKSMKMQQE----VVEMRKKNEEFKKLA--------------LAGI 243
           +Q+ L++  E QE EK++++Q+E     +E +KK EE ++LA               AG 
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGA 782

Query: 244 GQPVKKSVSQVTKSVDFHFRTDERIKQHPK-NQEEY-KEVNF--TSELRKHPSSPARV-T 298
            + +  +V   + +   +  T +  +  PK N + Y  ++N   +++   HP  P     
Sbjct: 783 SKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWA 842

Query: 299 KGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRS 346
           +G  + +             E   T +PL   +ED  K++  RYH R+
Sbjct: 843 RGTPLSQAIIHQYYHPPNLLELFGTILPL--DLEDIFKKSKPRYHKRT 888



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 64/305 (20%), Positives = 116/305 (38%), Gaps = 40/305 (13%)

Query: 438 EKRIQERESKKKTEDEHFE-----FHSRPCPT----KILEDVVGVPEKKVLPITVPKSPA 488
           ++ + E + ++  EDE  +       S PCP     + L   +   ++  + +T   +P 
Sbjct: 454 KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPR 513

Query: 489 FALKNRI------RMPTKEDEEE--------DEPVVIKAQPVPHYGVPFKPQIPEARTVE 534
             +K+ I      RM  KE E +        +E   ++ Q V         ++   R   
Sbjct: 514 SVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER 573

Query: 535 ICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFC 594
           +      +R++  Q+++EKK +  QK      K              KK     ++E   
Sbjct: 574 LRKV-LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632

Query: 595 LETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGS 654
               +    +   W  Q EEE R Q+     K        QE      E K +AE     
Sbjct: 633 ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-----EQERLRKAAEAKRLAE----- 682

Query: 655 LVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHK 714
                 Q   E+R +ER+E E+R  E   Q+ ++ E    ++E ++++E  +  REL  +
Sbjct: 683 ------QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736

Query: 715 ANPIR 719
              +R
Sbjct: 737 EKALR 741



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 42/199 (21%), Positives = 91/199 (45%), Gaps = 26/199 (13%)

Query: 537 PFSFDSRDKERQ----LQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEP 592
           P   D ++KERQ    L+++++ ++L++ +V + K           L E K+K   ++  
Sbjct: 525 PLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRR--------RLEEVKLKREERL-- 574

Query: 593 FCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLS 652
                  R  L+A+    Q++EE ++Q E    +    T  ++E  + +++ K  A    
Sbjct: 575 -------RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 627

Query: 653 GSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELV 712
              V+     A  K+ +E + L     E E ++ Q+L + + +EE+++  + A  +R   
Sbjct: 628 MEEVE-----ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 682

Query: 713 HKANPIRKYQGLEIKSSDQ 731
            +    R+ +  E +  +Q
Sbjct: 683 QREQERREQERREQERREQ 701



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 42/172 (24%), Positives = 83/172 (48%), Gaps = 11/172 (6%)

Query: 540 FDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDR 599
           F   D++ +  KE+++ E +  +  K  A  +   +     E++ + +  ++    E +R
Sbjct: 599 FAQIDEKTEKAKEERLAEEKAKK--KAAAKKMEEVEARRKQEEEARRLRWLQQE--EEER 654

Query: 600 RGALKAQTWKHQLEEELRQQKEAACF-KARPNTVISQEPFVPKKEKKSVAEGLSGSLVQE 658
           R     Q  K + +E LR+  EA    + R      QE    +++++   E       ++
Sbjct: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER---REQERREQERREQERREQ 711

Query: 659 PFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQ---EEEQKKEELARL 707
             QLA ++R +E++ L+      E +KA +L++ +LQ   EE++KKEE  RL
Sbjct: 712 ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 763



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 10/112 (8%)

Query: 600 RGALKAQTWKHQLEEELRQQK----EAACFKARPNTVISQEPFVPKKEKKSVAEGLSGS- 654
           R A +A+    Q E+E R+Q+    E    + R      QE  + ++E++   E L    
Sbjct: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731

Query: 655 -LVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELA 705
            L +    L  +K   +R+  EK+  E +    Q+L E +LQEE++KK + A
Sbjct: 732 ELQEREKALRLQKEQLQRELEEKKKKEEQ----QRLAERQLQEEQEKKAKEA 779



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 35/172 (20%), Positives = 69/172 (40%), Gaps = 27/172 (15%)

Query: 83  KEAEKENLVEQSIPSNACSSLEV-----EAAISRKTPAQPQRRSLRLSAQKDLEQK---- 133
           ++ E E L  Q +  +    LE      E  + +   A+ +   ++   +K +EQK    
Sbjct: 543 RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602

Query: 134 --------EKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKK---PEEEGSAHQDTAEK 182
                   E+   + KAK+ A    ++E+   +K +    + +    EEE   HQ+  +K
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662

Query: 183 NASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEE 234
                ++   +        A+ K L    EQE  +  + +QE  E  ++ +E
Sbjct: 663 KKEEEQERLRK-------AAEAKRLAEQREQERREQERREQERREQERREQE 707


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 46/162 (28%), Positives = 76/162 (46%), Gaps = 15/162 (9%)

Query: 556 KELQKGEVPKFKALPLPHFDT--INLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLE 613
           +EL+K      + LPL   +   I L  K++K   +   F L   +   L+ + W+   E
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 278

Query: 614 EELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQ- 672
           EELR+Q++    K R      +E    ++E+    EG      QE      EKR +E++ 
Sbjct: 279 EELREQEK----KIRKQ----EEKMWRQEERLREQEGKMRE--QEEKMWRQEKRLREQEK 328

Query: 673 ELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHK 714
           EL ++  E+  QK  + +E ++QE+E+K  E     RE   K
Sbjct: 329 ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 111/632 (17%), Positives = 234/632 (37%), Gaps = 116/632 (18%)

Query: 86  EKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRC 145
           EK  L E        +  E++  + R     PQ ++  L  +   +++E    + K ++ 
Sbjct: 232 EKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 291

Query: 146 ATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQK 205
              +   E    ++++    K + +EE    Q   EK     EK             +QK
Sbjct: 292 EEKMWRQE----ERLREQEGKMREQEEKMWRQ---EKRLREQEKELREQEKELR---EQK 341

Query: 206 FLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRT- 264
            L+  EEQ  E+  KM ++  +MR++ E+  +     + +  K+   Q  K  D   R  
Sbjct: 342 ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE-ERLWEQEKQMREQEQKMRDQEERMW 400

Query: 265 ---------DERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKR 315
                    +ER+++  K  E+ +++    ++++         +     +     + K R
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460

Query: 316 TFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTK 375
             +ET      + +Q E   K+  N +    K+     LP +    K+    +    + K
Sbjct: 461 EEEET------MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE--KLWEQEKMQEQEEK 512

Query: 376 HRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDL 435
              +    +   E+  +E +  +Q K + +E                             
Sbjct: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM-------------------------W 547

Query: 436 EIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRI 495
           E E++++++E K   ++E  E  ++    K  +      E+K             ++   
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ-----EEK-------------MREEE 589

Query: 496 RMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKI 555
           RM  +E +  +E  +++ Q         K Q  E +  E          +E+  ++E+K+
Sbjct: 590 RMREREKKMREEEEMMREQEE-------KMQEQEEKMQE---------QEEKMWEQEEKM 633

Query: 556 KELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEE 615
           +E ++                  + E++ K   Q E    E  R    K + W+H+  +E
Sbjct: 634 QEQEE-----------------KMWEQEEKMWEQEEKMW-EQQRLPEQKEKLWEHEKMQE 675

Query: 616 LRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQEL- 674
             + +E      +   +  QE    K +++         + +E      EK+ +E +E+ 
Sbjct: 676 QEKMQE------QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729

Query: 675 ---EKRMAEVEAQKAQQLEEARLQEEEQKKEE 703
              E++M E E +  +Q EE   QEE+  ++E
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 36/192 (18%), Positives = 90/192 (46%), Gaps = 11/192 (5%)

Query: 542 SRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRG 601
           +RD+E ++Q+E++I+E +K    K +       +     +K+ +N+ + E    +  R  
Sbjct: 439 TRDQEEKMQEEERIREREK----KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 494

Query: 602 ALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQ 661
             K + W    E+E  Q++E   ++ +   +  QE    +++K    E +     ++   
Sbjct: 495 EQKEKLW----EQEKMQEQEEKIWE-QEEKIRDQEEMWGQEKKMWRQEKMREQ--EDQMW 547

Query: 662 LATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKY 721
              EK   + Q++  +   +E +  +Q ++   QEE+ ++EE  R R + + +   + + 
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607

Query: 722 QGLEIKSSDQPL 733
           Q  +++  ++ +
Sbjct: 608 QEEKMQEQEEKM 619



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 56/281 (19%), Positives = 121/281 (43%), Gaps = 19/281 (6%)

Query: 435 LEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNR 494
           ++ E+RI+ERE K + E+E           K  E++    EK+     +P+     L  +
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQ-KQEENMWEQEEKEWQQQRLPEQKE-KLWEQ 503

Query: 495 IRMPTKEDE--EEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQL--Q 550
            +M  +E++  E++E +  + +        ++ +    +  ++       RD+E+++  Q
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563

Query: 551 KEKKIKELQKGEVPKF-KALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWK 609
           +E+  K+ Q+ E   + +   +   + +   EKK++   ++            ++ Q  K
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM------------MREQEEK 611

Query: 610 HQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAK 669
            Q +EE  Q++E   ++        +E    ++EK    E       + P Q       +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671

Query: 670 ERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRE 710
           + QE EK   + E    Q+  E + QE+E+K  +  ++R E
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 32/166 (19%), Positives = 86/166 (51%), Gaps = 9/166 (5%)

Query: 543 RDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGA 602
           R +ER  ++E K++E ++    + K L     + +   EK+++   ++     + ++   
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELREQKELRE---QEEQMQE 352

Query: 603 LKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQL 662
            + + W+   EE++R+Q+E      +   +  QE  + ++E+K + +       Q+    
Sbjct: 353 QEEKMWEQ--EEKMREQEEKMW--RQEERLWEQEKQMREQEQK-MRDQEERMWEQDERLR 407

Query: 663 ATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLR 708
             E+R +E++++ +++ ++  +K  Q +E + +++E+K +E  R+R
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 33/172 (19%), Positives = 80/172 (46%), Gaps = 30/172 (17%)

Query: 543 RDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGA 602
           R++E++L+++K+++E ++                  + E++ K   Q E    + ++   
Sbjct: 331 REQEKELREQKELREQEE-----------------QMQEQEEKMWEQEEKMREQEEKMWR 373

Query: 603 LKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQL 662
            + + W+   E+++R+Q++    + +   +  Q+  + +KE++   +      V++    
Sbjct: 374 QEERLWEQ--EKQMREQEQK--MRDQEERMWEQDERLREKEERMREQEKMWEQVEKM--- 426

Query: 663 ATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHK 714
              +  K+ QE EK+  +   Q+ +  EE R++E E+K  E     RE   K
Sbjct: 427 ---REEKKMQEQEKKTRD---QEEKMQEEERIREREKKMREEEETMREQEEK 472



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 29/121 (23%), Positives = 56/121 (46%), Gaps = 7/121 (5%)

Query: 596 ETDRRGALKAQTWKH--QLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSG 653
           E + R   + + W+   ++ EE + Q++    K R      QE    ++ +K + E    
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEK--KTRDQEEKMQEEERIREREKKMREEEET 465

Query: 654 SLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQK---KEELARLRRE 710
              QE      E+   E++E E +   +  QK +  E+ ++QE+E+K   +EE  R + E
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525

Query: 711 L 711
           +
Sbjct: 526 M 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,800,295
Number of Sequences: 37866
Number of extensions: 1585853
Number of successful extensions: 14109
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 625
Number of HSP's that attempted gapping in prelim test: 8830
Number of HSP's gapped (non-prelim): 4057
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.